## Fri Nov  8 19:44:08 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bins_4635/CMS2_bin.44.fa -m mmseqs --itype genome -o CMS2_bin.44 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/CMS2_bin.44 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
CMS2_k127_1019804_0	1246484.D479_13977	7.637e-25	110.0	2DQNH@1|root,337SB@2|Bacteria,1VIPB@1239|Firmicutes,4HPUA@91061|Bacilli	91061|Bacilli	S	Protein of unknown function (DUF2812)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2812
CMS2_k127_1019804_1	1476973.JMMB01000007_gene2466	1.056e-24	106.0	COG1695@1|root,COG1695@2|Bacteria,1VANP@1239|Firmicutes,25CVD@186801|Clostridia,25U8F@186804|Peptostreptococcaceae	186801|Clostridia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
CMS2_k127_1019804_2	471853.Bcav_0812	3.12e-07	59.0	2EE4N@1|root,337ZA@2|Bacteria,2IMPW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1033594_0	1408422.JHYF01000017_gene1871	0.0	2760.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1033594_5	331678.Cphamn1_0706	8.874e-12	66.0	COG4804@1|root,COG4804@2|Bacteria	2|Bacteria	S	nuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1016
CMS2_k127_1033594_1	237368.SCABRO_03209	0.0	1546.0	COG0243@1|root,COG1104@1|root,COG0243@2|Bacteria,COG1104@2|Bacteria,2J1TP@203682|Planctomycetes	203682|Planctomycetes	CE	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5,Molybdopterin,Molydop_binding
CMS2_k127_1033594_2	1279009.ADICEAN_01524	4.196e-85	293.0	COG4301@1|root,COG4301@2|Bacteria,4NEFC@976|Bacteroidetes,47KDA@768503|Cytophagia	976|Bacteroidetes	S	Histidine-specific methyltransferase, SAM-dependent	egtD	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
CMS2_k127_1033594_4	86416.Clopa_4755	1.098e-25	112.0	COG1846@1|root,COG1846@2|Bacteria,1VCHE@1239|Firmicutes,25CPQ@186801|Clostridia,36M4J@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
CMS2_k127_1033594_6	1097668.BYI23_B011810	6.104e-11	66.0	COG2337@1|root,COG2337@2|Bacteria,1N0JV@1224|Proteobacteria,2VV5S@28216|Betaproteobacteria,1K8V6@119060|Burkholderiaceae	28216|Betaproteobacteria	T	of a toxin-antitoxin	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
CMS2_k127_1036620_6	509191.AEDB02000094_gene4290	1.138e-07	59.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_31,PP-binding,ketoacyl-synt
CMS2_k127_1036620_3	711393.AYRX01000103_gene5911	4.658e-139	461.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_1036620_1	1009370.ALO_00935	0.0	1521.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_1036620_5	1122135.KB893168_gene2002	2.051e-112	377.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_11,Methyltransf_12,PP-binding,ketoacyl-synt
CMS2_k127_1036620_4	711393.AYRX01000103_gene5911	5.735e-130	434.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_1036620_2	755731.Clo1100_2632	0.0	1397.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1036620_0	1195236.CTER_0312	0.0	1641.0	COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_1037826_1	1379270.AUXF01000001_gene2030	1.441e-49	184.0	COG0300@1|root,COG0300@2|Bacteria,1ZUD2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS2_k127_1037826_2	1121098.HMPREF1534_02894	9.103e-33	141.0	COG1748@1|root,COG1748@2|Bacteria	2|Bacteria	E	saccharopine dehydrogenase activity	-	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4166,Sacchrp_dh_NADP
CMS2_k127_1037826_0	439235.Dalk_1565	2.119e-57	211.0	COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,42P9B@68525|delta/epsilon subdivisions,2WMCP@28221|Deltaproteobacteria,2MMBX@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
CMS2_k127_1040168_23	324925.Ppha_2513	1.248e-42	165.0	arCOG06916@1|root,30456@2|Bacteria,1FF5T@1090|Chlorobi	1090|Chlorobi	S	Domain of unknown function (DUF4276)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4276
CMS2_k127_1040168_11	1122212.AULO01000010_gene81	1.212e-115	384.0	COG4637@1|root,COG4637@2|Bacteria,1ND40@1224|Proteobacteria,1RPX7@1236|Gammaproteobacteria,1XMJ6@135619|Oceanospirillales	135619|Oceanospirillales	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21
CMS2_k127_1040168_27	398767.Glov_2250	4.665e-28	116.0	COG4226@1|root,COG4226@2|Bacteria,1MZYR@1224|Proteobacteria,42WDN@68525|delta/epsilon subdivisions,2WRW3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM HicB family	-	-	-	-	-	-	-	-	-	-	-	-	HicB
CMS2_k127_1040168_29	391612.CY0110_23456	1.517e-22	99.0	2CT64@1|root,32SSN@2|Bacteria,1G88J@1117|Cyanobacteria	1117|Cyanobacteria	S	HicA toxin of bacterial toxin-antitoxin,	hicA	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
CMS2_k127_1040168_33	1120980.JQKH01000009_gene1419	1.011e-13	80.0	COG0790@1|root,COG0790@2|Bacteria,1RK0C@1224|Proteobacteria,2VTTF@28216|Betaproteobacteria,2KRG4@206351|Neisseriales	206351|Neisseriales	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
CMS2_k127_1040168_36	1535422.ND16A_0069	0.0004972	46.0	COG1848@1|root,COG1848@2|Bacteria,1QZUI@1224|Proteobacteria,1SAA0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
CMS2_k127_1040168_30	1535422.ND16A_0070	4.049e-17	83.0	2AMWN@1|root,31CTF@2|Bacteria,1NEAZ@1224|Proteobacteria,1SHED@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1040168_8	1229487.AMYW01000009_gene1226	2.29e-159	510.0	COG1834@1|root,COG1834@2|Bacteria	2|Bacteria	E	dimethylargininase activity	-	-	2.1.4.1	ko:K00613	ko00260,ko00330,ko01100,map00260,map00330,map01100	M00047	R00565,R01989	RC00024,RC02749	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidinotransf
CMS2_k127_1040168_4	118005.AWNK01000004_gene1064	9.613e-307	1001.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1040168_6	509191.AEDB02000067_gene916	1.25e-195	625.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_1040168_7	1007103.AFHW01000028_gene1656	1.5e-178	618.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	1007103.AFHW01000028_gene1656|-	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1040168_5	573061.Clocel_2482	1.218e-274	893.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1040168_9	711393.AYRX01000103_gene5911	2.472e-140	465.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_1040168_1	641107.CDLVIII_0709	0.0	1980.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
CMS2_k127_1040168_0	1009370.ALO_00935	0.0	2506.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_1040168_2	755731.Clo1100_2632	0.0	1371.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1040168_10	502025.Hoch_6312	2.063e-134	468.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_1040168_34	1121373.KB903664_gene2542	7.404e-13	83.0	COG1404@1|root,COG1520@1|root,COG3291@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,COG3291@2|Bacteria,4NF1M@976|Bacteroidetes,47KVM@768503|Cytophagia	976|Bacteroidetes	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS2_k127_1040168_18	398512.JQKC01000014_gene1599	1.058e-72	278.0	COG0739@1|root,COG4870@1|root,COG0739@2|Bacteria,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185,GBS_Bsp-like,OapA,Peptidase_C1,Peptidase_M23
CMS2_k127_1040168_15	335543.Sfum_1269	4.818e-98	328.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,2MQ6Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
CMS2_k127_1040168_24	443144.GM21_2372	4.884e-41	163.0	COG1191@1|root,COG1191@2|Bacteria	2|Bacteria	K	sigma factor activity	-	-	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	HTH_23,Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_1040168_19	688269.Theth_0229	2.729e-63	224.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CMS2_k127_1040168_26	292563.Cyast_0889	1.238e-28	117.0	2C1FP@1|root,32YNH@2|Bacteria,1G9AM@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1040168_22	555779.Dthio_PD0660	1.022e-50	181.0	COG4226@1|root,COG4226@2|Bacteria,1MZE7@1224|Proteobacteria,42SRH@68525|delta/epsilon subdivisions,2WPUV@28221|Deltaproteobacteria,2MCE2@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	HicB family	-	-	-	-	-	-	-	-	-	-	-	-	HicB
CMS2_k127_1040168_28	391625.PPSIR1_04398	1.461e-27	116.0	COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,42RJS@68525|delta/epsilon subdivisions,2WQSB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Thioesterase superfamily	yciA	-	-	ko:K10806	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
CMS2_k127_1040168_3	1121035.AUCH01000004_gene429	0.0	1343.0	COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria	1224|Proteobacteria	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
CMS2_k127_1040168_14	204669.Acid345_2603	9.656e-102	351.0	COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria,2JP3M@204432|Acidobacteriia	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS2_k127_1040168_12	204669.Acid345_2603	2.588e-114	387.0	COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria,2JP3M@204432|Acidobacteriia	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS2_k127_1040168_25	580327.Tthe_1393	2.749e-35	141.0	COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,24J7Y@186801|Clostridia,42GR6@68295|Thermoanaerobacterales	186801|Clostridia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS2_k127_1040168_13	1047013.AQSP01000128_gene426	4.321e-104	347.0	COG1899@1|root,COG1899@2|Bacteria,2NP1S@2323|unclassified Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1040168_20	648996.Theam_1370	1.755e-61	230.0	COG2204@1|root,COG2204@2|Bacteria,2G3R2@200783|Aquificae	200783|Aquificae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_1040168_17	192952.MM_0391	5.342e-86	324.0	COG5276@1|root,arCOG02565@2157|Archaea	2157|Archaea	O	LVIVD repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
CMS2_k127_1040168_32	1089548.KI783301_gene1861	3.363e-15	91.0	COG3866@1|root,COG3866@2|Bacteria	2|Bacteria	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_1040168_16	439235.Dalk_0237	1.323e-97	362.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_1040168_21	402777.KB235899_gene4898	1.23e-51	209.0	COG2931@1|root,COG3210@1|root,COG3266@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3266@2|Bacteria,COG3391@2|Bacteria,1G4T5@1117|Cyanobacteria,1HHYV@1150|Oscillatoriales	1117|Cyanobacteria	U	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,Haemagg_act,HemolysinCabind
CMS2_k127_1044833_15	1047013.AQSP01000112_gene391	1.373e-34	140.0	COG3307@1|root,COG3307@2|Bacteria,2NPHS@2323|unclassified Bacteria	2|Bacteria	M	O-Antigen ligase	tuaE	-	-	ko:K16705	-	-	-	-	ko00000	-	-	-	Wzy_C
CMS2_k127_1044833_7	1121456.ATVA01000012_gene2942	3.435e-99	352.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,42NB4@68525|delta/epsilon subdivisions,2WK9E@28221|Deltaproteobacteria,2M8NV@213115|Desulfovibrionales	28221|Deltaproteobacteria	DM	PFAM lipopolysaccharide biosynthesis protein	wzc2	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
CMS2_k127_1044833_13	1047013.AQSP01000112_gene388	6.324e-56	205.0	COG4464@1|root,COG4464@2|Bacteria,2NPKP@2323|unclassified Bacteria	2|Bacteria	GM	protein tyrosine phosphatase activity	ywqE	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
CMS2_k127_1044833_20	671143.DAMO_2346	1.234e-19	102.0	COG0484@1|root,COG3307@1|root,COG0484@2|Bacteria,COG3307@2|Bacteria,2NPHS@2323|unclassified Bacteria	2|Bacteria	M	O-Antigen ligase	-	-	-	ko:K02847	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	DnaJ,Wzy_C
CMS2_k127_1044833_9	1047013.AQSP01000112_gene389	4.877e-95	320.0	COG1596@1|root,COG1596@2|Bacteria,2NPNM@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide export protein	-	-	-	ko:K01991,ko:K20988	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
CMS2_k127_1044833_16	278957.ABEA03000005_gene4394	3.169e-29	137.0	2C3QH@1|root,330WN@2|Bacteria,46Y5F@74201|Verrucomicrobia,3K90T@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1044833_21	243090.RB4375	9.001e-17	96.0	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF642
CMS2_k127_1044833_10	439235.Dalk_0237	3.661e-85	319.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_1044833_8	929558.SMGD1_1375	8.338e-99	339.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42MVS@68525|delta/epsilon subdivisions,2YRUW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_1044833_12	862908.BMS_3108	6.253e-62	226.0	COG0535@1|root,COG0535@2|Bacteria,1Q4MW@1224|Proteobacteria,4347F@68525|delta/epsilon subdivisions,2MUKJ@213481|Bdellovibrionales,2X32C@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
CMS2_k127_1044833_5	502025.Hoch_1667	1.238e-134	453.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_1044833_2	933262.AXAM01000019_gene1089	3.682e-271	842.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria,2MHVG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2834	Prismane
CMS2_k127_1044833_1	1291050.JAGE01000002_gene3550	2.008e-297	931.0	COG0331@1|root,COG2070@1|root,COG0331@2|Bacteria,COG2070@2|Bacteria,1UG0E@1239|Firmicutes,25F9X@186801|Clostridia	186801|Clostridia	I	Acyl transferase domain	-	-	-	ko:K15329,ko:K15355	-	-	-	-	ko00000,ko01008	-	-	-	Acyl_transf_1,NMO
CMS2_k127_1044833_19	1237149.C900_00572	2.201e-20	93.0	COG0236@1|root,COG0236@2|Bacteria,4NW1C@976|Bacteroidetes	976|Bacteroidetes	IQ	Phosphopantetheine attachment site	-	-	-	ko:K15337	-	-	-	-	ko00000,ko01008	-	-	-	PP-binding
CMS2_k127_1044833_4	1291050.JAGE01000002_gene3674	3.469e-166	532.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,3WGGB@541000|Ruminococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	-	-	-	-	-	-	-	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS2_k127_1044833_3	1536772.R70723_17160	1.698e-184	584.0	COG3425@1|root,COG3425@2|Bacteria,1TR4K@1239|Firmicutes,4HA67@91061|Bacilli,26QP0@186822|Paenibacillaceae	91061|Bacilli	I	Hydroxymethylglutaryl-coenzyme A synthase C terminal	-	-	-	ko:K15311	-	-	-	-	ko00000,ko01008	-	-	-	HMG_CoA_synt_C,HMG_CoA_synt_N
CMS2_k127_1044833_11	44251.PDUR_14140	4.415e-76	263.0	COG1024@1|root,COG1024@2|Bacteria,1TRGW@1239|Firmicutes,4HBJK@91061|Bacilli,26SDQ@186822|Paenibacillaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	-	ko:K15312	-	-	-	-	ko00000,ko01008	-	-	-	ECH_1
CMS2_k127_1044833_6	1410632.JHWW01000020_gene370	2.113e-119	398.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,27J0I@186928|unclassified Lachnospiraceae	186801|Clostridia	IQ	AMP-binding enzyme	fadD	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
CMS2_k127_1044833_17	143224.JQMD01000002_gene2031	2.232e-23	109.0	COG0500@1|root,COG2226@2|Bacteria,4NJZ2@976|Bacteroidetes	976|Bacteroidetes	Q	Ubiquinone biosynthesis methyltransferase UbiE	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
CMS2_k127_1044833_22	1463936.JOJI01000008_gene5721	1.21e-15	79.0	2DR4P@1|root,33A5F@2|Bacteria,2GVV3@201174|Actinobacteria	201174|Actinobacteria	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
CMS2_k127_1044833_0	349520.PPE_03011	0.0	2816.0	COG2227@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	pksR	-	-	ko:K13613,ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_1045656_0	1443665.JACA01000052_gene1875	1.255e-164	549.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,1HZEZ@117743|Flavobacteriia,2YKIU@290174|Aquimarina	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_1045907_0	1501230.ET33_18925	0.0	2406.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_1065911_0	536232.CLM_0374	1e-323	1023.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1076010_0	536232.CLM_0373	0.0	1853.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1076010_6	1047013.AQSP01000128_gene419	2.308e-218	691.0	COG3653@1|root,COG3653@2|Bacteria,2NNQ0@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
CMS2_k127_1076010_9	1047013.AQSP01000140_gene2497	4.861e-189	620.0	COG2866@1|root,COG2866@2|Bacteria,2NQNH@2323|unclassified Bacteria	2|Bacteria	E	Zinc carboxypeptidase	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
CMS2_k127_1076010_22	886293.Sinac_4894	2.111e-32	130.0	COG1595@1|root,COG1595@2|Bacteria,2J3UT@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_1076010_26	1005704.HMPREF9968_1926	1.053e-09	70.0	COG3613@1|root,COG3613@2|Bacteria,1VEM7@1239|Firmicutes,4HXZ3@91061|Bacilli	91061|Bacilli	F	nucleoside 2-deoxyribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1076010_27	1047013.AQSP01000132_gene1736	2.51e-09	71.0	28WP9@1|root,2ZINZ@2|Bacteria	1047013.AQSP01000132_gene1736|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1076010_7	1047013.AQSP01000140_gene2497	4.815e-207	675.0	COG2866@1|root,COG2866@2|Bacteria,2NQNH@2323|unclassified Bacteria	2|Bacteria	E	Zinc carboxypeptidase	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
CMS2_k127_1076010_10	388413.ALPR1_01110	8.892e-156	520.0	COG4188@1|root,COG4188@2|Bacteria,4NKC2@976|Bacteroidetes,47TN2@768503|Cytophagia	976|Bacteroidetes	S	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Chlorophyllase2
CMS2_k127_1076010_16	1163409.UUA_14047	1.358e-66	236.0	COG3409@1|root,COG3409@2|Bacteria,1QYWY@1224|Proteobacteria,1T506@1236|Gammaproteobacteria,1XB01@135614|Xanthomonadales	135614|Xanthomonadales	M	CHAP domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,PG_binding_1
CMS2_k127_1076010_13	1237149.C900_01592	3.319e-103	350.0	295M7@1|root,2ZSYM@2|Bacteria,4NNH9@976|Bacteroidetes,47UGS@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1076010_25	1121920.AUAU01000005_gene972	1.63e-18	88.0	COG1308@1|root,COG1308@2|Bacteria,3Y60R@57723|Acidobacteria	57723|Acidobacteria	K	Domain of unknown function (DUF4342)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
CMS2_k127_1076010_18	349521.HCH_00950	5.665e-44	169.0	COG2339@1|root,COG2339@2|Bacteria	2|Bacteria	D	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
CMS2_k127_1076010_5	945713.IALB_0430	1.121e-223	702.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	csdA	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS2_k127_1076010_17	1122194.AUHU01000002_gene2646	4.121e-49	198.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1T4K6@1236|Gammaproteobacteria,46DC0@72275|Alteromonadaceae	1236|Gammaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	ppkA	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase,PEGA,Pkinase
CMS2_k127_1076010_20	237368.SCABRO_03544	2.659e-37	161.0	COG0515@1|root,COG0666@1|root,COG0790@1|root,COG0515@2|Bacteria,COG0666@2|Bacteria,COG0790@2|Bacteria,2J1KC@203682|Planctomycetes	2|Bacteria	KLT	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4,Sel1,TPR_16,TPR_19,TonB_C
CMS2_k127_1076010_19	28072.Nos7524_2231	1.188e-39	157.0	2EMFU@1|root,33F4J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_8
CMS2_k127_1076010_21	28072.Nos7524_2231	1.184e-34	143.0	2EMFU@1|root,33F4J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_8
CMS2_k127_1076010_15	394503.Ccel_0972	3.664e-96	329.0	COG1819@1|root,COG1819@2|Bacteria,1TSPC@1239|Firmicutes,24D1S@186801|Clostridia,36ES5@31979|Clostridiaceae	186801|Clostridia	CG	TIGRFAM glycosyltransferase, MGT family	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
CMS2_k127_1076010_4	402777.KB235898_gene5728	1.357e-308	997.0	COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1HEH0@1150|Oscillatoriales	1117|Cyanobacteria	Q	Acyl transferase domain in polyketide synthase (PKS) enzymes.	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_1076010_2	1042163.BRLA_c025640	0.0	1407.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1076010_14	398512.JQKC01000015_gene4655	4.231e-99	336.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
CMS2_k127_1076010_8	509191.AEDB02000085_gene2717	1.21e-192	619.0	COG1032@1|root,COG1032@2|Bacteria,1UZQC@1239|Firmicutes,24PDA@186801|Clostridia,3WQ4E@541000|Ruminococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_1076010_24	1291050.JAGE01000002_gene3645	1.067e-19	102.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,3WGN4@541000|Ruminococcaceae	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_1076010_12	711393.AYRX01000103_gene5911	1.066e-115	394.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_1076010_11	711393.AYRX01000103_gene5911	1.087e-119	405.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_1076010_1	1196323.ALKF01000205_gene4114	0.0	1540.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1076010_3	573061.Clocel_2482	0.0	1290.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1091640_0	509191.AEDB02000082_gene2572	3.145e-316	1005.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_31,PP-binding,ketoacyl-synt
CMS2_k127_1092990_1	511051.CSE_02660	7.53e-69	250.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2,DUF234
CMS2_k127_1092990_4	338963.Pcar_2425	0.0006171	45.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
CMS2_k127_1092990_2	1144275.COCOR_01591	7.668e-43	172.0	COG0457@1|root,COG2819@1|root,COG0457@2|Bacteria,COG2819@2|Bacteria,1R54Q@1224|Proteobacteria	1224|Proteobacteria	S	hydrolase of the alpha beta superfamily	-	-	-	ko:K07017	-	-	-	-	ko00000	-	-	-	Esterase
CMS2_k127_1092990_0	909663.KI867150_gene2328	4.586e-107	354.0	COG2227@1|root,COG2227@2|Bacteria,1QZT3@1224|Proteobacteria,42QXG@68525|delta/epsilon subdivisions,2WMWI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS2_k127_1092990_3	926692.AZYG01000096_gene1903	2.358e-11	67.0	COG5464@1|root,COG5464@2|Bacteria,1UGME@1239|Firmicutes,248B2@186801|Clostridia	186801|Clostridia	S	transposase, YhgA-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
CMS2_k127_1099855_2	70601.3258262	7.915e-13	81.0	COG0582@1|root,arCOG01241@2157|Archaea,2XV3E@28890|Euryarchaeota,242ZK@183968|Thermococci	183968|Thermococci	J	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	xerA	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
CMS2_k127_1099855_0	479437.Elen_0747	4.405e-53	199.0	COG0464@1|root,COG0464@2|Bacteria,2GN05@201174|Actinobacteria	201174|Actinobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS2_k127_1099855_1	1235803.C825_03312	6.094e-18	97.0	2E57E@1|root,32ZZZ@2|Bacteria,4P02J@976|Bacteroidetes,2FP1S@200643|Bacteroidia,22Z60@171551|Porphyromonadaceae	976|Bacteroidetes	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1105506_34	1499967.BAYZ01000156_gene556	4.472e-15	77.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K20444	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS2_k127_1105506_35	272123.Anacy_0626	3.651e-12	72.0	COG5513@1|root,COG5513@2|Bacteria	2|Bacteria	G	serine-type aminopeptidase activity	-	-	-	ko:K02030,ko:K14475	ko05143,map05143	M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3	-	-	Inhibitor_I42
CMS2_k127_1105506_9	1047013.AQSP01000128_gene454	2.33e-133	434.0	COG0404@1|root,COG0404@2|Bacteria,2NNSR@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
CMS2_k127_1105506_28	262724.TT_C0149	3.263e-41	155.0	COG0509@1|root,COG0509@2|Bacteria,1WJYK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
CMS2_k127_1105506_11	1047013.AQSP01000128_gene452	5.046e-132	434.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
CMS2_k127_1105506_2	1047013.AQSP01000128_gene451	1.27e-178	571.0	COG1003@1|root,COG1003@2|Bacteria,2NNSG@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
CMS2_k127_1105506_16	1047013.AQSP01000128_gene450	7.508e-109	359.0	COG0752@1|root,COG0752@2|Bacteria,2NNZ3@2323|unclassified Bacteria	2|Bacteria	J	Glycyl-tRNA synthetase, alpha subunit	glyQ	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016875,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01878,ko:K14164	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF1260.b3560,iAF987.Gmet_2942,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360	tRNA-synt_2e
CMS2_k127_1105506_14	1151292.QEW_2986	9.582e-122	415.0	COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,248RS@186801|Clostridia,25R5C@186804|Peptostreptococcaceae	186801|Clostridia	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
CMS2_k127_1105506_15	926561.KB900620_gene3230	1.894e-118	395.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia,3WAI4@53433|Halanaerobiales	186801|Clostridia	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
CMS2_k127_1105506_13	1047013.AQSP01000132_gene1731	1.418e-122	421.0	COG0795@1|root,COG0795@2|Bacteria,2NP9S@2323|unclassified Bacteria	2|Bacteria	S	Permease YjgP YjgQ family protein	lptF	-	-	ko:K07091,ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
CMS2_k127_1105506_23	981369.JQMJ01000004_gene6258	4.285e-63	224.0	COG1215@1|root,COG1215@2|Bacteria,2GJTE@201174|Actinobacteria,2NEC1@228398|Streptacidiphilus	201174|Actinobacteria	M	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
CMS2_k127_1105506_33	1121423.JONT01000014_gene1270	5.264e-25	119.0	COG0702@1|root,COG0702@2|Bacteria,1UNU6@1239|Firmicutes	1239|Firmicutes	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1105506_25	1296415.JACC01000027_gene1374	7.482e-53	207.0	COG2303@1|root,COG2303@2|Bacteria,4PH1X@976|Bacteroidetes,1IMAH@117743|Flavobacteriia,2YJ6R@290174|Aquimarina	976|Bacteroidetes	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1105506_19	313612.L8106_01632	3.013e-87	300.0	COG3568@1|root,COG3568@2|Bacteria,1G36X@1117|Cyanobacteria,1H97M@1150|Oscillatoriales	1117|Cyanobacteria	S	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS2_k127_1105506_26	324925.Ppha_2424	2.484e-48	183.0	2EDYH@1|root,337TB@2|Bacteria,1FEFX@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1105506_32	324925.Ppha_2425	1.645e-25	118.0	2E9II@1|root,333RI@2|Bacteria,1FEZP@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1105506_4	667014.Thein_2136	1.473e-156	505.0	COG0172@1|root,COG0172@2|Bacteria,2GGY4@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
CMS2_k127_1105506_21	1047013.AQSP01000083_gene1189	5.894e-80	282.0	COG1459@1|root,COG1459@2|Bacteria,2NP2J@2323|unclassified Bacteria	2|Bacteria	U	Type II secretion system (T2SS), protein F	pilC	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
CMS2_k127_1105506_1	1047013.AQSP01000083_gene1188	8.383e-186	593.0	COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria	2|Bacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	gspE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
CMS2_k127_1105506_18	1047013.AQSP01000036_gene1385	3.282e-99	349.0	COG4796@1|root,COG4796@2|Bacteria	2|Bacteria	U	Type ii and iii secretion system protein	pulQ	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Cohesin,STN,Secretin,Secretin_N
CMS2_k127_1105506_27	1499967.BAYZ01000088_gene5106	2.378e-43	166.0	COG0095@1|root,COG0095@2|Bacteria	2|Bacteria	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
CMS2_k127_1105506_17	1033810.HLPCO_002424	6.37e-107	362.0	COG1249@1|root,COG1249@2|Bacteria,2NNTI@2323|unclassified Bacteria	2|Bacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	pdhD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
CMS2_k127_1105506_8	1123008.KB905708_gene1004	7.399e-134	439.0	COG0508@1|root,COG0508@2|Bacteria,4NED0@976|Bacteroidetes,2FNQF@200643|Bacteroidia,22XWE@171551|Porphyromonadaceae	976|Bacteroidetes	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	bfmBB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CMS2_k127_1105506_7	1123008.KB905708_gene1003	7.628e-144	462.0	COG0022@1|root,COG0022@2|Bacteria,4NE71@976|Bacteroidetes,2FQB7@200643|Bacteroidia	976|Bacteroidetes	C	dehydrogenase E1 component	bfmBA	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
CMS2_k127_1105506_12	1123008.KB905708_gene1002	2.533e-129	423.0	COG1071@1|root,COG1071@2|Bacteria,4NF2J@976|Bacteroidetes,2FWJH@200643|Bacteroidia	976|Bacteroidetes	C	TPP-dependent acetoin dehydrogenase complex, E1 component, alpha subunit	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
CMS2_k127_1105506_3	929556.Solca_0522	6.96e-174	560.0	COG1032@1|root,COG1032@2|Bacteria,4PHMM@976|Bacteroidetes,1IWI2@117747|Sphingobacteriia	976|Bacteroidetes	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1105506_10	338963.Pcar_0993	2.695e-132	435.0	COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,42MAE@68525|delta/epsilon subdivisions,2WKFF@28221|Deltaproteobacteria,43T88@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM Xanthine uracil vitamin C permease	pbuG	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
CMS2_k127_1105506_31	459349.CLOAM1816	4.275e-29	121.0	COG1917@1|root,COG1917@2|Bacteria,2NQ91@2323|unclassified Bacteria	2|Bacteria	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS2_k127_1105506_30	1499967.BAYZ01000181_gene4509	7.581e-32	130.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS2_k127_1105506_0	1121904.ARBP01000010_gene2419	5.594e-299	947.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47MTC@768503|Cytophagia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS2_k127_1105506_22	760192.Halhy_3425	6.318e-72	255.0	COG0845@1|root,COG0845@2|Bacteria,4NF23@976|Bacteroidetes,1IS62@117747|Sphingobacteriia	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS2_k127_1105506_20	1519464.HY22_01490	1.366e-81	290.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_1105506_29	313606.M23134_02270	1.477e-36	147.0	COG1309@1|root,COG1309@2|Bacteria,4NTB4@976|Bacteroidetes,47RD7@768503|Cytophagia	976|Bacteroidetes	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
CMS2_k127_1105506_5	502025.Hoch_1667	8.74e-154	506.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_1105506_38	1449347.JQLN01000003_gene6073	2.776e-10	74.0	COG3170@1|root,COG3291@1|root,COG3170@2|Bacteria,COG3291@2|Bacteria,2GKNE@201174|Actinobacteria,2M2FF@2063|Kitasatospora	201174|Actinobacteria	NU	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	3.4.24.3	ko:K01387	-	-	-	-	ko00000,ko01000,ko01002,ko02042	-	-	-	PKD,PPC,Peptidase_M9,Peptidase_M9_N
CMS2_k127_1105506_24	1237149.C900_05552	1.353e-57	229.0	COG3227@1|root,COG3291@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,4NJK3@976|Bacteroidetes,47TYM@768503|Cytophagia	976|Bacteroidetes	E	Pregnancy-associated plasma protein-A	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_M43,fn3
CMS2_k127_1105506_6	502025.Hoch_1667	4.674e-144	494.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_1105506_37	1219084.AP014508_gene1160	4.101e-11	66.0	COG1404@1|root,COG1404@2|Bacteria,2GDZM@200918|Thermotogae	200918|Thermotogae	O	Subtilase family	-	-	3.4.21.62	ko:K01342	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
CMS2_k127_1117020_0	755731.Clo1100_2633	1.074e-202	655.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1122972_9	448385.sce4137	6.454e-118	401.0	COG3321@1|root,COG3321@2|Bacteria	2|Bacteria	Q	synthase	-	-	-	ko:K13613,ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_1122972_32	324925.Ppha_0871	4.66e-64	231.0	COG0332@1|root,COG0332@2|Bacteria,1FD8U@1090|Chlorobi	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS2_k127_1122972_30	324925.Ppha_0871	1.027e-64	234.0	COG0332@1|root,COG0332@2|Bacteria,1FD8U@1090|Chlorobi	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS2_k127_1122972_2	380358.XALC_1514	3.859e-200	639.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	carbamoyl transferase, NodU family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS2_k127_1122972_44	1237149.C900_00572	3.215e-23	100.0	COG0236@1|root,COG0236@2|Bacteria,4NW1C@976|Bacteroidetes	976|Bacteroidetes	IQ	Phosphopantetheine attachment site	-	-	-	ko:K15337	-	-	-	-	ko00000,ko01008	-	-	-	PP-binding
CMS2_k127_1122972_42	273057.SSO2518	1.147e-26	124.0	arCOG07204@1|root,arCOG07204@2157|Archaea,2XRRE@28889|Crenarchaeota	28889|Crenarchaeota	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS2_k127_1122972_4	44251.PDUR_14135	2.149e-177	564.0	COG3425@1|root,COG3425@2|Bacteria,1TR4K@1239|Firmicutes,4HA67@91061|Bacilli,26QP0@186822|Paenibacillaceae	91061|Bacilli	I	Hydroxymethylglutaryl-coenzyme A synthase C terminal	-	-	-	ko:K15311	-	-	-	-	ko00000,ko01008	-	-	-	HMG_CoA_synt_C,HMG_CoA_synt_N
CMS2_k127_1122972_22	44251.PDUR_14140	1.576e-77	267.0	COG1024@1|root,COG1024@2|Bacteria,1TRGW@1239|Firmicutes,4HBJK@91061|Bacilli,26SDQ@186822|Paenibacillaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	-	ko:K15312	-	-	-	-	ko00000,ko01008	-	-	-	ECH_1
CMS2_k127_1122972_24	991.IW20_19895	1.346e-74	259.0	COG1024@1|root,COG1024@2|Bacteria,4NJY3@976|Bacteroidetes,1I88S@117743|Flavobacteriia	976|Bacteroidetes	I	Enoyl-CoA hydratase/isomerase	-	-	-	ko:K15313	-	-	-	-	ko00000,ko01008	-	-	-	ECH_1
CMS2_k127_1122972_29	1220534.B655_2396	8.334e-66	232.0	COG2020@1|root,arCOG03580@2157|Archaea,2Y4MT@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT
CMS2_k127_1122972_14	138119.DSY4423	1.537e-96	332.0	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia,263EX@186807|Peptococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_1122972_16	138119.DSY4423	5.539e-94	325.0	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia,263EX@186807|Peptococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_1122972_51	756499.Desde_0761	0.0005401	43.0	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia,263EX@186807|Peptococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_1122972_13	756499.Desde_0761	2.225e-98	337.0	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia,263EX@186807|Peptococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_1122972_49	756499.Desde_0761	2.426e-09	66.0	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia,263EX@186807|Peptococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_1122972_15	138119.DSY4423	2.203e-95	329.0	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia,263EX@186807|Peptococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_1122972_11	138119.DSY4423	1.646e-102	349.0	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia,263EX@186807|Peptococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_1122972_12	138119.DSY4423	8.726e-99	338.0	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia,263EX@186807|Peptococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_1122972_31	313606.M23134_01959	4.209e-64	235.0	COG1506@1|root,COG1506@2|Bacteria,4NGW1@976|Bacteroidetes,47MCA@768503|Cytophagia	976|Bacteroidetes	E	Secretory lipase	-	-	-	-	-	-	-	-	-	-	-	-	LIP,Peptidase_S9
CMS2_k127_1122972_5	1291050.JAGE01000002_gene3674	1.677e-152	493.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,3WGGB@541000|Ruminococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	-	-	-	-	-	-	-	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS2_k127_1122972_35	1054860.KB913030_gene5767	6.627e-43	169.0	COG0496@1|root,COG0496@2|Bacteria,2IFAX@201174|Actinobacteria	201174|Actinobacteria	S	survival protein SurE	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
CMS2_k127_1122972_37	639282.DEFDS_1443	1.897e-42	159.0	COG2905@1|root,COG2905@2|Bacteria,2GGGX@200930|Deferribacteres	200930|Deferribacteres	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS2_k127_1122972_1	1047013.AQSP01000091_gene642	0.0	1056.0	COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	sfrB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0055114,GO:0071944	1.12.1.3,1.17.1.10,1.6.5.3	ko:K00335,ko:K15022,ko:K18331	ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00134,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
CMS2_k127_1122972_38	909663.KI867151_gene2964	3.318e-39	151.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,43DNM@68525|delta/epsilon subdivisions,2X6M5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K05586	ko00190,ko01100,map00190,map01100	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx
CMS2_k127_1122972_6	177437.HRM2_16870	2.592e-150	498.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MIH6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
CMS2_k127_1122972_3	1121405.dsmv_2921	4.66e-179	582.0	COG0493@1|root,COG2878@1|root,COG0493@2|Bacteria,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,42MPF@68525|delta/epsilon subdivisions,2X5BJ@28221|Deltaproteobacteria,2MISB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Putative Fe-S cluster	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fer4,Fer4_20,Fer4_9,Pyr_redox_2
CMS2_k127_1122972_27	1121098.HMPREF1534_00811	8.097e-69	238.0	COG4657@1|root,COG4657@2|Bacteria,4NGEZ@976|Bacteroidetes,2FM9J@200643|Bacteroidia,4AM7X@815|Bacteroidaceae	976|Bacteroidetes	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
CMS2_k127_1122972_23	1121405.dsmv_3393	1.812e-75	258.0	COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,42NVB@68525|delta/epsilon subdivisions,2WK6R@28221|Deltaproteobacteria,2MINN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
CMS2_k127_1122972_34	1408428.JNJP01000001_gene3123	7.847e-45	170.0	COG4659@1|root,COG4659@2|Bacteria,1PPK1@1224|Proteobacteria,42TAI@68525|delta/epsilon subdivisions,2WNZU@28221|Deltaproteobacteria,2M9S6@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfG	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
CMS2_k127_1122972_25	933262.AXAM01000029_gene2745	6.752e-74	260.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,42QE5@68525|delta/epsilon subdivisions,2WM8R@28221|Deltaproteobacteria,2MHVT@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
CMS2_k127_1122972_36	1121396.KB893123_gene1132	7.47e-43	172.0	COG4656@1|root,COG4656@2|Bacteria,1QMZ4@1224|Proteobacteria,42NJ5@68525|delta/epsilon subdivisions,2WKCG@28221|Deltaproteobacteria,2MIQX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,RnfC_N
CMS2_k127_1122972_48	882.DVU_2791	4.167e-14	81.0	29W60@1|root,30HR4@2|Bacteria,1RJNX@1224|Proteobacteria,42T35@68525|delta/epsilon subdivisions,2WP20@28221|Deltaproteobacteria,2M98P@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Class III cytochrome C family	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
CMS2_k127_1122972_45	747365.Thena_0468	1.012e-21	99.0	COG0640@1|root,COG0640@2|Bacteria,1VPBF@1239|Firmicutes,24VJN@186801|Clostridia	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
CMS2_k127_1122972_43	880073.Calab_0422	4.098e-25	109.0	COG0745@1|root,COG0745@2|Bacteria,2NRCE@2323|unclassified Bacteria	2|Bacteria	KT	cheY-homologous receiver domain	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
CMS2_k127_1122972_41	1274374.CBLK010000009_gene4377	4.08e-30	129.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HB1B@91061|Bacilli,26T15@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,sCache_like
CMS2_k127_1122972_7	1121440.AUMA01000003_gene2888	6.654e-133	436.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,42RHV@68525|delta/epsilon subdivisions,2WNH5@28221|Deltaproteobacteria,2MA5W@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Nickel-dependent hydrogenase	hyhL	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
CMS2_k127_1122972_26	237368.SCABRO_02488	1.499e-72	252.0	COG1941@1|root,COG1941@2|Bacteria,2IXWB@203682|Planctomycetes	203682|Planctomycetes	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
CMS2_k127_1122972_17	237368.SCABRO_02489	8.596e-94	316.0	COG0543@1|root,COG0543@2|Bacteria,2IYBB@203682|Planctomycetes	203682|Planctomycetes	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
CMS2_k127_1122972_28	519442.Huta_2602	9.631e-67	240.0	COG1145@1|root,arCOG05128@2157|Archaea,2XY2U@28890|Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S dicluster domain	-	-	1.12.98.4	ko:K17996	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	Fer4_22
CMS2_k127_1122972_39	1121920.AUAU01000012_gene2646	1.163e-38	154.0	COG0509@1|root,COG2204@1|root,COG0509@2|Bacteria,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GAF_2,GCV_H,Response_reg
CMS2_k127_1122972_8	316067.Geob_1632	3.203e-132	446.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MRH@68525|delta/epsilon subdivisions,2WM8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase HAMP	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_3
CMS2_k127_1122972_21	1120973.AQXL01000115_gene656	6.571e-81	282.0	COG0686@1|root,COG0686@2|Bacteria,1TNZ5@1239|Firmicutes,4HABX@91061|Bacilli,277YI@186823|Alicyclobacillaceae	91061|Bacilli	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
CMS2_k127_1122972_50	997350.HMPREF9129_0558	8.622e-08	60.0	COG1342@1|root,COG1433@1|root,COG1342@2|Bacteria,COG1433@2|Bacteria,1TRMQ@1239|Firmicutes,25E8C@186801|Clostridia	186801|Clostridia	O	dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	DUF134,Nitro_FeMo-Co
CMS2_k127_1122972_40	289377.HL41_04870	1.57e-30	124.0	COG1433@1|root,COG1433@2|Bacteria,2GHXV@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
CMS2_k127_1122972_18	944479.JQLX01000014_gene1656	1.693e-90	306.0	COG1149@1|root,COG1149@2|Bacteria,1MVPB@1224|Proteobacteria,42MJ5@68525|delta/epsilon subdivisions,2WJ9M@28221|Deltaproteobacteria,2M6B0@213113|Desulfurellales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
CMS2_k127_1122972_19	760142.Hipma_1225	2.84e-83	285.0	COG1149@1|root,COG1149@2|Bacteria,1NCD9@1224|Proteobacteria,42PHV@68525|delta/epsilon subdivisions,2WKDZ@28221|Deltaproteobacteria,2M6FQ@213113|Desulfurellales	28221|Deltaproteobacteria	C	CobQ/CobB/MinD/ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
CMS2_k127_1122972_47	338966.Ppro_1955	1.159e-14	78.0	COG1433@1|root,COG1433@2|Bacteria,1MZ77@1224|Proteobacteria,42U3G@68525|delta/epsilon subdivisions,2WQ5N@28221|Deltaproteobacteria,43VC1@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
CMS2_k127_1122972_0	1168034.FH5T_20555	0.0	1114.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,4NFTI@976|Bacteroidetes,2FNSJ@200643|Bacteroidia	976|Bacteroidetes	C	CoA binding domain protein	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
CMS2_k127_1122972_10	760568.Desku_2155	7.293e-107	361.0	COG3829@1|root,COG3829@2|Bacteria,1V0EF@1239|Firmicutes,24DXA@186801|Clostridia	186801|Clostridia	KT	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_9,Sigma54_activat
CMS2_k127_1122972_33	880073.Calab_3539	1.251e-48	185.0	COG0589@1|root,COG0589@2|Bacteria,2NPUM@2323|unclassified Bacteria	2|Bacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS2_k127_1122972_20	1047013.AQSP01000067_gene2199	6.237e-81	285.0	COG3379@1|root,COG3379@2|Bacteria,2NQEW@2323|unclassified Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
CMS2_k127_1122972_46	373903.Hore_22330	7.22e-20	90.0	2DG7P@1|root,2ZUUE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1126122_1	1348583.ATLH01000001_gene3601	4.033e-30	121.0	COG3550@1|root,COG3550@2|Bacteria,4NG6N@976|Bacteroidetes,1HWVW@117743|Flavobacteriia,1FAAR@104264|Cellulophaga	976|Bacteroidetes	S	Pfam:HipA_N	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	HipA_C
CMS2_k127_1126122_0	28115.HR11_05950	0.0	1948.0	COG0210@1|root,COG0514@1|root,COG0210@2|Bacteria,COG0514@2|Bacteria,4NIAS@976|Bacteroidetes,2FP12@200643|Bacteroidia,22W5W@171551|Porphyromonadaceae	976|Bacteroidetes	L	DNA helicase	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,DEAD,Helicase_C,UvrD-helicase,UvrD_C
CMS2_k127_11366_3	1499967.BAYZ01000153_gene1551	3.284e-167	574.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,A2M_recep,CarboxypepD_reg,Plug,Thiol-ester_cl
CMS2_k127_11366_2	1122176.KB903552_gene3695	1.861e-260	856.0	COG1672@1|root,COG2319@1|root,COG4249@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,COG4249@2|Bacteria,4NR06@976|Bacteroidetes,1IWX9@117747|Sphingobacteriia	976|Bacteroidetes	L	ATPase involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_11366_0	315730.BcerKBAB4_1784	0.0	2285.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	ko:K15654,ko:K15655,ko:K15662,ko:K15663,ko:K16093,ko:K16095	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
CMS2_k127_11366_1	1195236.CTER_0305	0.0	1125.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,3WSTF@541000|Ruminococcaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	-	-	-	-	-	-	-	-	-	Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_1138511_22	1122971.BAME01000030_gene2991	4.642e-08	60.0	COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,2FMPG@200643|Bacteroidia,22W7G@171551|Porphyromonadaceae	976|Bacteroidetes	T	COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_1138511_10	1265503.KB905162_gene3522	1.871e-71	256.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1S6MK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
CMS2_k127_1138511_18	1265503.KB905162_gene3522	9.062e-29	123.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1S6MK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
CMS2_k127_1138511_12	1265503.KB905162_gene3522	9.18e-51	207.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1S6MK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
CMS2_k127_1138511_2	1499967.BAYZ01000153_gene1548	2.525e-172	574.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_13,AAA_22,AAA_35,PDDEXK_9
CMS2_k127_1138511_16	1499967.BAYZ01000105_gene3534	7.956e-37	143.0	2C914@1|root,32T2A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1138511_1	493475.GARC_5354	1.524e-287	906.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,469M5@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
CMS2_k127_1138511_23	1528106.JRJE01000009_gene1750	1.328e-06	51.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,2U2VJ@28211|Alphaproteobacteria,2JS16@204441|Rhodospirillales	204441|Rhodospirillales	T	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14
CMS2_k127_1138511_7	1453505.JASY01000001_gene3755	4.021e-91	309.0	COG1073@1|root,COG1073@2|Bacteria,4NGG4@976|Bacteroidetes,1IMUE@117743|Flavobacteriia,2NUXE@237|Flavobacterium	976|Bacteroidetes	S	Dienelactone hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	DLH,Hydrolase_4
CMS2_k127_1138511_20	393921.HQ45_00470	9.483e-10	71.0	COG0810@1|root,COG4219@1|root,COG0810@2|Bacteria,COG4219@2|Bacteria,4NDWS@976|Bacteroidetes,2FNCU@200643|Bacteroidia,22X60@171551|Porphyromonadaceae	976|Bacteroidetes	KMT	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Peptidase_M56,TonB_C
CMS2_k127_1138511_27	215803.DB30_3768	0.0006926	49.0	COG5662@1|root,COG5662@2|Bacteria,1QAKH@1224|Proteobacteria,434DQ@68525|delta/epsilon subdivisions,2WYQS@28221|Deltaproteobacteria,2Z0DX@29|Myxococcales	28221|Deltaproteobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
CMS2_k127_1138511_17	649747.HMPREF0083_00974	2.062e-33	136.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HI9N@91061|Bacilli,26XD3@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_1138511_21	1500897.JQNA01000002_gene772	2.41e-09	59.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,1K1YU@119060|Burkholderiaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS2_k127_1138511_15	1429916.X566_14330	1.586e-43	177.0	COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,2TU37@28211|Alphaproteobacteria,3JUMM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
CMS2_k127_1138511_19	489825.LYNGBM3L_22580	1.274e-11	72.0	COG1988@1|root,COG1988@2|Bacteria,1G9P5@1117|Cyanobacteria,1HG2W@1150|Oscillatoriales	1117|Cyanobacteria	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
CMS2_k127_1138511_26	1121396.KB893064_gene1166	0.0005916	52.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
CMS2_k127_1138511_14	1121918.ARWE01000001_gene585	3.318e-47	176.0	COG1280@1|root,COG1280@2|Bacteria,1RD4I@1224|Proteobacteria,42SG8@68525|delta/epsilon subdivisions,2WPQA@28221|Deltaproteobacteria,43V8F@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
CMS2_k127_1138511_13	1218084.BBJK01000016_gene1701	8.871e-48	190.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2VZUN@28216|Betaproteobacteria,1K6T0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
CMS2_k127_1138511_6	1117318.PRUB_01189	1.022e-110	380.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,2Q2WU@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	cocE	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS2_k127_1138511_24	33035.JPJF01000019_gene4274	2.919e-06	57.0	COG2207@1|root,COG2207@2|Bacteria,1V062@1239|Firmicutes,25B1G@186801|Clostridia	2|Bacteria	K	transcriptional regulator (AraC family)	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
CMS2_k127_1138511_4	761193.Runsl_1905	1.458e-140	458.0	COG2355@1|root,COG2355@2|Bacteria,4NEBG@976|Bacteroidetes,47JQ6@768503|Cytophagia	976|Bacteroidetes	E	PFAM Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273,ko:K01274	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_C26,Peptidase_M19
CMS2_k127_1138511_3	1047013.AQSP01000114_gene696	1.808e-158	520.0	COG5276@1|root,COG5276@2|Bacteria,2NQ2P@2323|unclassified Bacteria	2|Bacteria	P	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,LVIVD
CMS2_k127_1138511_5	1047013.AQSP01000114_gene697	6.817e-114	374.0	COG2006@1|root,COG2006@2|Bacteria,2NQF7@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS2_k127_1138511_11	1047013.AQSP01000132_gene1697	8.043e-65	239.0	COG0285@1|root,COG0285@2|Bacteria,2NP60@2323|unclassified Bacteria	2|Bacteria	H	Belongs to the folylpolyglutamate synthase family	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0166,iSB619.SA_RS08370	Mur_ligase_C,Mur_ligase_M
CMS2_k127_1138511_9	903818.KI912269_gene55	8.177e-76	288.0	COG0515@1|root,COG0515@2|Bacteria	903818.KI912269_gene55|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1138511_0	880073.Calab_3271	2.936e-288	899.0	COG1297@1|root,COG1297@2|Bacteria,2NP0C@2323|unclassified Bacteria	2|Bacteria	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
CMS2_k127_1138511_8	439235.Dalk_0237	7.181e-86	295.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_1157470_1	933262.AXAM01000018_gene1012	8.574e-08	59.0	2ESEZ@1|root,33JZN@2|Bacteria,1NJQX@1224|Proteobacteria,42XER@68525|delta/epsilon subdivisions,2WSM5@28221|Deltaproteobacteria,2MM89@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
CMS2_k127_1157470_0	1298593.TOL_2969	1.615e-117	395.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,1XR9E@135619|Oceanospirillales	135619|Oceanospirillales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
CMS2_k127_1161405_0	697284.ERIC2_c18050	1.107e-309	978.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1161405_1	755731.Clo1100_1301	4.072e-86	298.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,Thioesterase,ketoacyl-synt
CMS2_k127_1172952_52	521045.Kole_1660	2.098e-19	89.0	COG0227@1|root,COG0227@2|Bacteria,2GDFC@200918|Thermotogae	200918|Thermotogae	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
CMS2_k127_1172952_34	1047013.AQSP01000140_gene2458	2.245e-46	172.0	COG1611@1|root,COG1611@2|Bacteria,2NPJB@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DNA_processg_A,Lysine_decarbox
CMS2_k127_1172952_27	1047013.AQSP01000140_gene2457	1.261e-58	212.0	COG0101@1|root,COG0101@2|Bacteria,2NPEC@2323|unclassified Bacteria	2|Bacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
CMS2_k127_1172952_6	1047013.AQSP01000037_gene1327	1.151e-139	452.0	COG1063@1|root,COG1063@2|Bacteria,2NPK3@2323|unclassified Bacteria	2|Bacteria	E	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS2_k127_1172952_7	933262.AXAM01000025_gene3401	3.124e-127	411.0	COG1830@1|root,COG1830@2|Bacteria,1MWJW@1224|Proteobacteria,42PHA@68525|delta/epsilon subdivisions,2WKBX@28221|Deltaproteobacteria,2MK4V@213118|Desulfobacterales	28221|Deltaproteobacteria	G	DeoC/LacD family aldolase	-	-	2.3.1.245	ko:K08321	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	DeoC
CMS2_k127_1172952_44	1382359.JIAL01000001_gene893	2.698e-31	127.0	COG0071@1|root,COG0071@2|Bacteria,3Y4TM@57723|Acidobacteria,2JJFI@204432|Acidobacteriia	204432|Acidobacteriia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS2_k127_1172952_8	56780.SYN_02213	1.776e-117	411.0	COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1R891@1224|Proteobacteria,42P2C@68525|delta/epsilon subdivisions,2WJZT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
CMS2_k127_1172952_45	386456.JQKN01000007_gene3172	6.52e-31	142.0	COG0642@1|root,COG2202@1|root,arCOG02352@1|root,arCOG06712@1|root,arCOG02352@2157|Archaea,arCOG02358@2157|Archaea,arCOG06712@2157|Archaea,arCOG06918@2157|Archaea	2157|Archaea	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	BAT,GAF,GAF_2,GAF_3,HATPase_c,HTH_10,HisKA,HisKA_4TM,PAS,PAS_3,PAS_4,PAS_9
CMS2_k127_1172952_49	283942.IL1096	3.019e-23	115.0	COG0745@1|root,COG0745@2|Bacteria,1R3UE@1224|Proteobacteria,1RRJX@1236|Gammaproteobacteria,2QG0Z@267893|Idiomarinaceae	1236|Gammaproteobacteria	T	cheY-homologous receiver domain	rssB	GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0009893,GO:0010556,GO:0010604,GO:0016989,GO:0019219,GO:0019222,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031647,GO:0031648,GO:0032268,GO:0032270,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0140110,GO:1903506,GO:2001141	3.1.3.3	ko:K02485,ko:K07315	-	-	-	-	ko00000,ko01000,ko02022,ko03021	-	-	-	Response_reg,SpoIIE
CMS2_k127_1172952_14	243231.GSU1249	8.794e-83	296.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria,43U1A@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
CMS2_k127_1172952_4	1121396.KB893079_gene859	6.506e-155	502.0	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42NMK@68525|delta/epsilon subdivisions,2WK6K@28221|Deltaproteobacteria,2MJD2@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_1172952_32	272123.Anacy_0627	7.967e-47	183.0	COG4870@1|root,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	3.4.22.15	ko:K01365,ko:K14475	ko04140,ko04142,ko04145,ko04210,ko04612,ko05143,ko05205,ko05323,ko05418,map04140,map04142,map04145,map04210,map04612,map05143,map05205,map05323,map05418	-	-	-	ko00000,ko00001,ko00537,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I42,Peptidase_C1
CMS2_k127_1172952_18	1185876.BN8_06708	3.544e-76	272.0	COG1404@1|root,COG1404@2|Bacteria,4NFFV@976|Bacteroidetes,47JYC@768503|Cytophagia	976|Bacteroidetes	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS2_k127_1172952_13	313606.M23134_02672	1.289e-97	352.0	COG0457@1|root,COG0642@1|root,COG0457@2|Bacteria,COG2205@2|Bacteria,4NI29@976|Bacteroidetes,47KZN@768503|Cytophagia	976|Bacteroidetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,TPR_12,TPR_8
CMS2_k127_1172952_36	313612.L8106_30180	2.152e-45	191.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G1QI@1117|Cyanobacteria,1H6XA@1150|Oscillatoriales	1117|Cyanobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,NB-ARC,TIR_2,TPR_10,TPR_12,TPR_7,TPR_8
CMS2_k127_1172952_39	765420.OSCT_2844	4.026e-40	173.0	COG0123@1|root,COG0123@2|Bacteria,2G5X3@200795|Chloroflexi,374Z1@32061|Chloroflexia	32061|Chloroflexia	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
CMS2_k127_1172952_19	247490.KSU1_C0727	9.445e-75	260.0	COG3527@1|root,COG3527@2|Bacteria,2J1NT@203682|Planctomycetes	203682|Planctomycetes	Q	Alpha-acetolactate decarboxylase	-	-	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660	-	R02948	RC00812	ko00000,ko00001,ko01000	-	-	-	AAL_decarboxy
CMS2_k127_1172952_28	247490.KSU1_C0727	8.605e-58	210.0	COG3527@1|root,COG3527@2|Bacteria,2J1NT@203682|Planctomycetes	203682|Planctomycetes	Q	Alpha-acetolactate decarboxylase	-	-	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660	-	R02948	RC00812	ko00000,ko00001,ko01000	-	-	-	AAL_decarboxy
CMS2_k127_1172952_9	1382306.JNIM01000001_gene2779	4.197e-109	362.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS2_k127_1172952_5	706587.Desti_5591	7.765e-146	480.0	COG0079@1|root,COG1492@1|root,COG0079@2|Bacteria,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,42M9K@68525|delta/epsilon subdivisions,2WJ22@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,Aminotran_1_2,CbiA,GATase_3,TP_methylase
CMS2_k127_1172952_17	439235.Dalk_3497	3.498e-76	267.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1QW1M@1224|Proteobacteria	1224|Proteobacteria	T	SMART PAS domain containing protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	-
CMS2_k127_1172952_26	216594.MMAR_3323	1.084e-60	224.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,234F0@1762|Mycobacteriaceae	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
CMS2_k127_1172952_12	216594.MMAR_3322	8.295e-98	332.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,233TJ@1762|Mycobacteriaceae	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS2_k127_1172952_15	1121472.AQWN01000005_gene2575	9.735e-83	298.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,267C6@186807|Peptococcaceae	186801|Clostridia	T	response regulator receiver	-	-	-	ko:K07714,ko:K10943	ko02020,ko05111,map02020,map05111	M00500,M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_1172952_22	1232410.KI421425_gene1562	6.057e-65	234.0	COG5557@1|root,COG5557@2|Bacteria,1QURB@1224|Proteobacteria,43BT1@68525|delta/epsilon subdivisions,2X73S@28221|Deltaproteobacteria,43SR9@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Pfam Polysulphide reductase, NrfD	actF	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1172952_48	338963.Pcar_2553	2.311e-25	110.0	COG2010@1|root,COG2010@2|Bacteria,1PWTD@1224|Proteobacteria,437B9@68525|delta/epsilon subdivisions,2X9ZG@28221|Deltaproteobacteria,43V90@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
CMS2_k127_1172952_3	338963.Pcar_2552	8.93e-194	612.0	COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,43SBI@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Polysulphide reductase, NrfD	moz	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
CMS2_k127_1172952_0	1232410.KI421425_gene1565	3.522e-272	864.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,43TY6@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS2_k127_1172952_30	1232410.KI421425_gene1566	3.178e-53	193.0	COG3474@1|root,COG3474@2|Bacteria,1QUNA@1224|Proteobacteria,42PVG@68525|delta/epsilon subdivisions,2X7M4@28221|Deltaproteobacteria,43VY9@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1172952_47	945713.IALB_1399	8.122e-30	134.0	COG4654@1|root,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Copper-bind,Cytochrom_C,Cytochrome_CBB3,F5_F8_type_C,Lipase_GDSL_2,PSCyt1
CMS2_k127_1172952_29	1121920.AUAU01000026_gene1433	2.266e-55	204.0	COG0109@1|root,COG0109@2|Bacteria,3Y3VI@57723|Acidobacteria	57723|Acidobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
CMS2_k127_1172952_16	1123326.JFBL01000017_gene2305	1.184e-77	270.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,42M7N@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.10.3.10,1.9.3.1	ko:K02275,ko:K02297	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX2,COX2_TM,COX_ARM,Cytochrom_C,Cytochrome_CBB3
CMS2_k127_1172952_54	1232410.KI421415_gene2987	1.081e-12	72.0	2EAMQ@1|root,334Q9@2|Bacteria,1NA2T@1224|Proteobacteria,42VC9@68525|delta/epsilon subdivisions,2WRD9@28221|Deltaproteobacteria,43SRT@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Prokaryotic Cytochrome C oxidase subunit IV	coxD	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
CMS2_k127_1172952_21	945713.IALB_1395	1.063e-67	236.0	COG1845@1|root,COG1845@2|Bacteria	2|Bacteria	C	cytochrome c oxidase, subunit III	coxC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
CMS2_k127_1172952_1	1121920.AUAU01000026_gene1437	2.013e-241	756.0	COG0843@1|root,COG0843@2|Bacteria,3Y2X6@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	-	-	-	-	-	-	-	-	-	-	COX1
CMS2_k127_1172952_20	207559.Dde_1822	6.13e-68	240.0	COG1999@1|root,COG1999@2|Bacteria,1R9EM@1224|Proteobacteria,42N5F@68525|delta/epsilon subdivisions,2WKG7@28221|Deltaproteobacteria,2M9V6@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems	sco	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	-
CMS2_k127_1172952_41	880073.Calab_3408	7.946e-34	136.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Cytochrome_C554,DUF11,SLH
CMS2_k127_1172952_55	382464.ABSI01000007_gene4134	1.959e-09	66.0	2E533@1|root,32ZW9@2|Bacteria,46SZX@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1172952_10	278957.ABEA03000200_gene4364	2.421e-105	378.0	COG0755@1|root,COG1333@1|root,COG0755@2|Bacteria,COG1333@2|Bacteria,46SIH@74201|Verrucomicrobia,3K7UF@414999|Opitutae	414999|Opitutae	O	PFAM cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
CMS2_k127_1172952_37	29486.NJ56_03445	6.421e-44	171.0	COG0697@1|root,COG0697@2|Bacteria,1MVGC@1224|Proteobacteria,1RMXB@1236|Gammaproteobacteria,41EAE@629|Yersinia	1236|Gammaproteobacteria	EG	EamA-like transporter family	yddG	GO:0003333,GO:0003674,GO:0005215,GO:0005302,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015179,GO:0015192,GO:0015196,GO:0015238,GO:0015318,GO:0015711,GO:0015801,GO:0015807,GO:0015823,GO:0015827,GO:0015828,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039	-	-	-	-	-	-	-	-	-	iBWG_1329.BWG_1294,iE2348C_1286.E2348C_1607,iECDH10B_1368.ECDH10B_1604,iECDH1ME8569_1439.ECDH1ME8569_1416,iECS88_1305.ECS88_1565,iEcDH1_1363.EcDH1_2175,iJO1366.b1473,iNRG857_1313.NRG857_07295,iSSON_1240.SSON_1651,iUMN146_1321.UM146_09675	EamA
CMS2_k127_1172952_33	335541.Swol_2092	1.752e-46	179.0	COG2199@1|root,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,24A8B@186801|Clostridia,42KU4@68298|Syntrophomonadaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS2_k127_1172952_25	1267533.KB906733_gene2989	1.208e-61	238.0	COG0642@1|root,COG2205@2|Bacteria,3Y2M7@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS2_k127_1172952_23	1267534.KB906755_gene4691	3.373e-62	221.0	COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria	57723|Acidobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_1172952_38	1499967.BAYZ01000028_gene1318	7.771e-43	169.0	COG0739@1|root,COG0739@2|Bacteria,2NPG3@2323|unclassified Bacteria	2|Bacteria	M	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
CMS2_k127_1172952_53	378806.STAUR_4816	3.644e-18	99.0	COG0745@1|root,COG0745@2|Bacteria,1N1N5@1224|Proteobacteria,42UP1@68525|delta/epsilon subdivisions,2WQAF@28221|Deltaproteobacteria,2YVKX@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_1172952_11	1047013.AQSP01000119_gene1319	3.953e-100	351.0	COG0525@1|root,COG0525@2|Bacteria,2NNKR@2323|unclassified Bacteria	2|Bacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iLJ478.TM1817	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
CMS2_k127_1172952_42	509191.AEDB02000048_gene4645	1.245e-32	137.0	COG0340@1|root,COG0340@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,3WHDB@541000|Ruminococcaceae	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
CMS2_k127_1172952_43	1123229.AUBC01000014_gene2955	3.58e-32	147.0	COG0265@1|root,COG0265@2|Bacteria,1NVK0@1224|Proteobacteria,2US7T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1172952_51	565033.GACE_0731	3.773e-22	105.0	COG1533@1|root,arCOG01290@2157|Archaea,2XTYE@28890|Euryarchaeota,2461F@183980|Archaeoglobi	183980|Archaeoglobi	L	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_1172952_56	1128421.JAGA01000002_gene382	0.000715	52.0	COG1807@1|root,COG3063@1|root,COG1807@2|Bacteria,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	pilF	-	-	ko:K02453,ko:K02656	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15	-	-	ANAPC5,Secretin,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
CMS2_k127_1172952_40	317936.Nos7107_4125	1.769e-37	163.0	COG0457@1|root,COG0714@1|root,COG4995@1|root,COG0457@2|Bacteria,COG0714@2|Bacteria,COG4995@2|Bacteria,1G33Z@1117|Cyanobacteria,1HRQA@1161|Nostocales	1117|Cyanobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,NB-ARC,TPR_12
CMS2_k127_1172952_31	1121405.dsmv_0634	6.389e-48	186.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M6C@68525|delta/epsilon subdivisions,2WM3G@28221|Deltaproteobacteria,2MIRH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
CMS2_k127_1172952_2	1499967.BAYZ01000061_gene5977	1.557e-232	766.0	COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria,2NNZT@2323|unclassified Bacteria	2|Bacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,HisKA_2,PAS_9,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_1172952_50	1047013.AQSP01000132_gene1736	1.294e-22	108.0	28WP9@1|root,2ZINZ@2|Bacteria	1047013.AQSP01000132_gene1736|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1172952_57	236097.ADG881_1931	0.0008801	51.0	2EDAW@1|root,33777@2|Bacteria,1NE47@1224|Proteobacteria,1SF3R@1236|Gammaproteobacteria,1XPY3@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1172952_24	1237149.C900_04559	5.579e-62	222.0	COG0745@1|root,COG0745@2|Bacteria,4NIQC@976|Bacteroidetes,47PDQ@768503|Cytophagia	976|Bacteroidetes	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_1172952_35	1267533.KB906733_gene2989	8.372e-46	189.0	COG0642@1|root,COG2205@2|Bacteria,3Y2M7@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS2_k127_1174704_0	509191.AEDB02000067_gene919	4.269e-265	847.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_118533_2	1196323.ALKF01000205_gene4116	0.0	1251.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_118533_0	755731.Clo1100_0890	0.0	2231.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_118533_3	1042163.BRLA_c025640	0.0	1183.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_118533_6	118005.AWNK01000004_gene1064	4.644e-178	599.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_118533_8	711393.AYRX01000103_gene5911	4.214e-129	453.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_118533_4	1009370.ALO_00935	0.0	1163.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_118533_5	509191.AEDB02000067_gene919	1.91e-271	881.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_118533_7	711393.AYRX01000103_gene5911	5.398e-139	460.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_118533_1	1227349.C170_04473	0.0	1862.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	pmxE	-	-	ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_1186233_6	1123058.KB894217_gene676	0.0009726	42.0	COG0348@1|root,COG0348@2|Bacteria,4NFDN@976|Bacteroidetes,1HXAK@117743|Flavobacteriia	976|Bacteroidetes	C	cytochrome C oxidase	ccoG	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
CMS2_k127_1186233_3	1185876.BN8_06510	2.546e-13	72.0	COG2336@1|root,COG2336@2|Bacteria,4NSWY@976|Bacteroidetes,47SRJ@768503|Cytophagia	976|Bacteroidetes	T	SpoVT / AbrB like domain	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
CMS2_k127_1186233_1	1121904.ARBP01000055_gene485	3.803e-195	659.0	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,47JBS@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_1186233_4	504472.Slin_6437	6.942e-06	59.0	2EKM2@1|root,33EAV@2|Bacteria,4NZ79@976|Bacteroidetes,47STW@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1186233_0	1237149.C900_04816	1.011e-229	762.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47TR0@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Response_reg,Y_Y_Y
CMS2_k127_1186233_2	313606.M23134_00174	6.682e-17	96.0	2B31B@1|root,30VE8@2|Bacteria,4PC7Y@976|Bacteroidetes,47WXZ@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1186233_5	411476.BACOVA_04363	3.95e-05	46.0	COG5464@1|root,COG5464@2|Bacteria,4NJT2@976|Bacteroidetes,2FQ31@200643|Bacteroidia,4AW7W@815|Bacteroidaceae	976|Bacteroidetes	S	PD-(D/E)XK nuclease family transposase	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_1187396_0	1121405.dsmv_3796	9.125e-44	178.0	COG3316@1|root,COG3316@2|Bacteria,1QWDK@1224|Proteobacteria,43CXP@68525|delta/epsilon subdivisions,2X85T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66
CMS2_k127_1187396_1	111781.Lepto7376_0368	1.843e-13	78.0	COG1345@1|root,COG1345@2|Bacteria	2|Bacteria	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	GO:0001539,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
CMS2_k127_1211997_1	767029.HMPREF9154_0827	1.825e-14	84.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
CMS2_k127_1211997_0	882086.SacxiDRAFT_1887	2.41e-22	112.0	COG1807@1|root,COG1807@2|Bacteria,2IEB9@201174|Actinobacteria,4E27D@85010|Pseudonocardiales	201174|Actinobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1225627_3	1278073.MYSTI_07843	1.471e-83	303.0	COG2204@1|root,COG3292@1|root,COG4191@1|root,COG2204@2|Bacteria,COG3292@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42Q3F@68525|delta/epsilon subdivisions,2WM2F@28221|Deltaproteobacteria,2YUEQ@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_1225627_5	335543.Sfum_3982	6.961e-43	177.0	COG4783@1|root,COG4783@2|Bacteria,1N30P@1224|Proteobacteria	1224|Proteobacteria	S	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1225627_6	742723.HMPREF9477_00208	1.221e-37	148.0	COG0350@1|root,COG0350@2|Bacteria,1VA03@1239|Firmicutes,24JAA@186801|Clostridia,27UCI@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
CMS2_k127_1225627_1	1254432.SCE1572_37375	1.544e-143	471.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,42N8C@68525|delta/epsilon subdivisions,2WM3N@28221|Deltaproteobacteria,2YUFY@29|Myxococcales	28221|Deltaproteobacteria	K	AlkA N-terminal domain	-	-	3.2.2.21	ko:K13529,ko:K13530	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
CMS2_k127_1225627_2	56107.Cylst_1842	8.257e-97	351.0	COG0745@1|root,COG2198@1|root,COG2202@1|root,COG2203@1|root,COG2204@1|root,COG3437@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG3437@2|Bacteria,COG5002@2|Bacteria,1G027@1117|Cyanobacteria,1HKPC@1161|Nostocales	1117|Cyanobacteria	T	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,Trans_reg_C
CMS2_k127_1225627_8	289377.HL41_03555	2.114e-17	91.0	COG0071@1|root,COG0071@2|Bacteria,2GHTW@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS2_k127_1225627_9	120017.I2G1B9	1.509e-09	68.0	COG2214@1|root,KOG0691@2759|Eukaryota,38GRI@33154|Opisthokonta,3NXFB@4751|Fungi,3UY5R@5204|Basidiomycota,3MZFJ@452284|Ustilaginomycotina	4751|Fungi	O	X-domain of DnaJ-containing	CAJ1	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0005933,GO:0006457,GO:0006605,GO:0006625,GO:0006626,GO:0006810,GO:0006839,GO:0006886,GO:0006996,GO:0007005,GO:0007006,GO:0007031,GO:0008104,GO:0008150,GO:0009987,GO:0012505,GO:0015031,GO:0015833,GO:0015919,GO:0016043,GO:0016558,GO:0017038,GO:0030544,GO:0031072,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043574,GO:0044424,GO:0044444,GO:0044464,GO:0044743,GO:0045040,GO:0045184,GO:0046907,GO:0051087,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070585,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072655,GO:0072657,GO:0072662,GO:0072663,GO:0090150,GO:0090151	-	-	-	-	-	-	-	-	-	-	DnaJ,DnaJ-X
CMS2_k127_1225627_7	1304885.AUEY01000041_gene3680	3.324e-31	127.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WQ7I@28221|Deltaproteobacteria,2MKT9@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Hsp20/alpha crystallin family	hspA-1	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS2_k127_1225627_0	518766.Rmar_2008	2.757e-217	681.0	COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,1FJ1P@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79	ko:K00128,ko:K00135	ko00010,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00027,M00135	R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS2_k127_1225627_4	1216007.AOPM01000078_gene1117	7.088e-54	198.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RRKU@1236|Gammaproteobacteria,2Q0YT@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1	fkpA	-	5.2.1.8	ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
CMS2_k127_122923_11	927658.AJUM01000043_gene687	1.248e-85	291.0	COG2271@1|root,COG2271@2|Bacteria,4PKTC@976|Bacteroidetes,2G3HT@200643|Bacteroidia	976|Bacteroidetes	G	Transporter, major facilitator family protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS2_k127_122923_25	1120973.AQXL01000067_gene13	2.326e-18	92.0	COG1595@1|root,COG1595@2|Bacteria,1V4CG@1239|Firmicutes,4HHEJ@91061|Bacilli	91061|Bacilli	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_122923_26	1047013.AQSP01000052_gene2591	2.259e-16	91.0	COG1933@1|root,COG1933@2|Bacteria,2NRP4@2323|unclassified Bacteria	2|Bacteria	L	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,PLDc_N,zf-ribbon_3,zinc_ribbon_2
CMS2_k127_122923_27	1121481.AUAS01000001_gene4332	1.862e-07	54.0	COG1569@1|root,COG1569@2|Bacteria,4NTR8@976|Bacteroidetes,47UYJ@768503|Cytophagia	976|Bacteroidetes	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
CMS2_k127_122923_16	666686.B1NLA3E_03390	6.309e-69	255.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HA3S@91061|Bacilli,1ZAY7@1386|Bacillus	91061|Bacilli	V	ABC transporter	ygaD	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
CMS2_k127_122923_1	1124780.ANNU01000078_gene757	9.443e-264	836.0	COG1506@1|root,COG1506@2|Bacteria,4NE60@976|Bacteroidetes,47JEM@768503|Cytophagia	976|Bacteroidetes	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS2_k127_122923_29	1047013.AQSP01000097_gene1952	1.372e-05	57.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,TolB_like
CMS2_k127_122923_9	1517682.HW49_10505	7.18e-93	323.0	COG0535@1|root,COG0535@2|Bacteria,4NMXM@976|Bacteroidetes,2FPWE@200643|Bacteroidia,230NK@171551|Porphyromonadaceae	976|Bacteroidetes	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS2_k127_122923_15	43354.JOIJ01000008_gene3116	1.426e-77	274.0	COG0500@1|root,COG2226@2|Bacteria,2IEI0@201174|Actinobacteria,4E86U@85010|Pseudonocardiales	201174|Actinobacteria	Q	Domain of unknown function (DUF4214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,Methyltransf_11
CMS2_k127_122923_18	290512.Paes_1915	4.693e-42	167.0	COG1572@1|root,COG1572@2|Bacteria,1FEDB@1090|Chlorobi	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
CMS2_k127_122923_12	5722.XP_001314730.1	1.532e-81	295.0	COG0666@1|root,KOG4177@2759|Eukaryota	2759|Eukaryota	I	spectrin binding	-	-	-	ko:K15502,ko:K15503	-	-	-	-	ko00000,ko01009,ko03400	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,DUF3447
CMS2_k127_122923_10	485913.Krac_0646	3.421e-89	312.0	COG0515@1|root,COG1716@1|root,COG0515@2|Bacteria,COG1716@2|Bacteria,2G8MA@200795|Chloroflexi	2|Bacteria	H	COGs COG0515 Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Cytochrom_c3_2,FHA,Pkinase
CMS2_k127_122923_14	706587.Desti_1624	4.748e-79	303.0	COG0457@1|root,COG0515@1|root,COG2319@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,42P8D@68525|delta/epsilon subdivisions,2WMH1@28221|Deltaproteobacteria,2MS9H@213462|Syntrophobacterales	28221|Deltaproteobacteria	KLT	WD40 repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_35,Pkinase,WD40
CMS2_k127_122923_23	234267.Acid_0954	2.336e-23	113.0	COG1408@1|root,COG1408@2|Bacteria,3Y5PS@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
CMS2_k127_122923_6	1121930.AQXG01000009_gene291	1.541e-138	454.0	COG0006@1|root,COG0006@2|Bacteria,4NF0F@976|Bacteroidetes,1IV0D@117747|Sphingobacteriia	976|Bacteroidetes	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
CMS2_k127_122923_20	177437.HRM2_30030	7.886e-33	139.0	2EKNX@1|root,33ECP@2|Bacteria,1NQHA@1224|Proteobacteria,42YEX@68525|delta/epsilon subdivisions,2WUPR@28221|Deltaproteobacteria,2MMYQ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_122923_8	96561.Dole_2647	2.308e-100	330.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2MHUF@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_122923_22	1047013.AQSP01000111_gene1677	2.098e-25	118.0	COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria	2|Bacteria	O	smart pdz dhr glgf	htrA	GO:0008150,GO:0009266,GO:0009628,GO:0050896	1.3.1.74,3.4.21.107	ko:K04691,ko:K04771,ko:K08070	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS2_k127_122923_28	745718.JADT01000017_gene1043	1.493e-06	58.0	2C3QT@1|root,32YUW@2|Bacteria,4NWNZ@976|Bacteroidetes,1I6M5@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_122923_24	240016.ABIZ01000001_gene40	1.291e-22	107.0	COG1266@1|root,COG1266@2|Bacteria,46WZJ@74201|Verrucomicrobia,2IVZM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
CMS2_k127_122923_4	1127673.GLIP_1210	4.3e-148	488.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,466B9@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
CMS2_k127_122923_7	1117314.PCIT_15805	8.121e-119	404.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,2Q2WU@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	cocE	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS2_k127_122923_0	1499967.BAYZ01000182_gene4425	0.0	1139.0	COG1529@1|root,COG1529@2|Bacteria,2NPHP@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS2_k127_122923_17	511051.CSE_07190	6.737e-57	202.0	COG2080@1|root,COG2080@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	coxS	-	1.2.5.3,1.3.99.16,1.3.99.8,1.5.99.14,1.5.99.4	ko:K03518,ko:K07302,ko:K13483,ko:K16879,ko:K19186,ko:K19819,ko:K20172	ko00230,ko00365,ko00760,ko01100,ko01120,map00230,map00365,map00760,map01100,map01120	M00546,M00810,M00811	R01768,R02103,R02860,R02987,R07514,R07946,R11168,R11179	RC00143,RC00589,RC01856,RC01860,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0374c	Fer2,Fer2_2
CMS2_k127_122923_13	1499967.BAYZ01000182_gene4423	3.793e-80	276.0	COG1319@1|root,COG1319@2|Bacteria,2NQ9S@2323|unclassified Bacteria	2|Bacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.17.1.4,1.2.5.3	ko:K03519,ko:K13479	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
CMS2_k127_122923_5	459349.CLOAM1598	6.615e-142	455.0	COG1878@1|root,COG1878@2|Bacteria,2NQ3K@2323|unclassified Bacteria	2|Bacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
CMS2_k127_122923_2	1499967.BAYZ01000016_gene6506	6.948e-222	697.0	COG0074@1|root,COG0074@2|Bacteria,2NQG1@2323|unclassified Bacteria	2|Bacteria	C	Protein of unknown function (DUF1116)	sucD	-	6.2.1.5	ko:K01902,ko:K02381	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,DUF1116,Ligase_CoA
CMS2_k127_122923_3	1499967.BAYZ01000016_gene6505	2.123e-168	543.0	COG0074@1|root,COG0074@2|Bacteria,2NQBH@2323|unclassified Bacteria	2|Bacteria	C	CoA-ligase	sucD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009361,GO:0032991,GO:0042709,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:1902494	6.2.1.5	ko:K01902,ko:K02381	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
CMS2_k127_122923_19	717231.Flexsi_1329	2.143e-39	153.0	COG1335@1|root,COG1335@2|Bacteria,2GFP3@200930|Deferribacteres	200930|Deferribacteres	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS2_k127_1231472_0	1117108.PAALTS15_22598	0.0	1103.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1231894_1	324925.Ppha_2424	6.373e-20	99.0	2EDYH@1|root,337TB@2|Bacteria,1FEFX@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1231894_0	324925.Ppha_2425	5.329e-20	96.0	2E9II@1|root,333RI@2|Bacteria,1FEZP@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_123550_1	1047013.AQSP01000130_gene1851	2.472e-133	436.0	COG1453@1|root,COG1453@2|Bacteria,2NNZZ@2323|unclassified Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
CMS2_k127_123550_3	933262.AXAM01000020_gene46	4.603e-30	124.0	COG1262@1|root,COG4249@1|root,COG1262@2|Bacteria,COG4249@2|Bacteria,1NQ5K@1224|Proteobacteria,42MAT@68525|delta/epsilon subdivisions,2WKY9@28221|Deltaproteobacteria,2MIBZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,Peptidase_C14
CMS2_k127_123550_6	7091.BGIBMGA014126-TA	4.112e-12	77.0	KOG2177@1|root,KOG2177@2759|Eukaryota,38F95@33154|Opisthokonta,3BA7J@33208|Metazoa,3CZWX@33213|Bilateria,41W93@6656|Arthropoda,3SI4S@50557|Insecta,443WW@7088|Lepidoptera	33208|Metazoa	O	NHL repeat	nhl-1	GO:0003008,GO:0003012,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006936,GO:0006941,GO:0006996,GO:0007010,GO:0007610,GO:0007626,GO:0008150,GO:0008152,GO:0008270,GO:0008345,GO:0009653,GO:0009987,GO:0010927,GO:0016043,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0022607,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030239,GO:0030537,GO:0031032,GO:0031674,GO:0032446,GO:0032501,GO:0032502,GO:0032989,GO:0036211,GO:0042592,GO:0042692,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043292,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044444,GO:0044449,GO:0044464,GO:0046716,GO:0046872,GO:0046914,GO:0048468,GO:0048646,GO:0048747,GO:0048856,GO:0048869,GO:0051146,GO:0055001,GO:0055002,GO:0060249,GO:0061061,GO:0065007,GO:0065008,GO:0070647,GO:0070925,GO:0071704,GO:0071840,GO:0097435,GO:0099080,GO:0099081,GO:0099512,GO:0140096,GO:1901564	2.3.2.27	ko:K11997,ko:K12035	ko05206,map05206	-	-	-	ko00000,ko00001,ko01000,ko03019,ko04121	-	-	-	NHL,zf-B_box,zf-C3HC4,zf-RING_UBOX
CMS2_k127_123550_4	391623.TERMP_00142	6.683e-21	96.0	COG1669@1|root,COG2361@1|root,arCOG01206@2157|Archaea,arCOG05024@2157|Archaea,2Y0GK@28890|Euryarchaeota,244JN@183968|Thermococci	183968|Thermococci	S	Protein of unknown function DUF86	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	DUF86
CMS2_k127_123550_5	1123278.KB893545_gene4792	3.782e-15	88.0	28JIH@1|root,2Z9BT@2|Bacteria,4NIF7@976|Bacteroidetes,47SD9@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3999
CMS2_k127_123550_0	1499967.BAYZ01000024_gene282	2.569e-137	460.0	COG5373@1|root,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	Otg1	-	-	-	-	-	-	-	-	-	-	-	DUF2339,DUF4167
CMS2_k127_123550_2	648996.Theam_0929	2.026e-31	131.0	COG2204@1|root,COG2204@2|Bacteria,2G4IR@200783|Aquificae	200783|Aquificae	T	response regulator	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_1236322_2	1128427.KB904821_gene3961	1.697e-140	493.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G15Q@1117|Cyanobacteria,1H7TC@1150|Oscillatoriales	1117|Cyanobacteria	L	tpr repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,Sel1,TPR_10
CMS2_k127_1236322_0	485918.Cpin_3405	3.648e-183	593.0	COG2185@1|root,COG4865@1|root,COG2185@2|Bacteria,COG4865@2|Bacteria,4NJUE@976|Bacteroidetes	976|Bacteroidetes	E	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	glmE	-	5.4.99.1	ko:K01846,ko:K19268	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_asp_mut_E
CMS2_k127_1236322_1	378806.STAUR_1298	1.274e-177	569.0	COG2234@1|root,COG2234@2|Bacteria,1R77P@1224|Proteobacteria,438J4@68525|delta/epsilon subdivisions,2X8TJ@28221|Deltaproteobacteria,2YX3Q@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS2_k127_1236322_3	760142.Hipma_0060	1.367e-65	236.0	COG0593@1|root,COG1943@1|root,COG0593@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42RDM@68525|delta/epsilon subdivisions,2WMYM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Chromosomal replication initiator, DnaA	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Bac_DnaA_C,Y1_Tnp
CMS2_k127_1236322_4	1278306.KB906919_gene1280	8.366e-31	124.0	2ERMG@1|root,33J6Y@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1236322_7	395961.Cyan7425_0119	1.426e-06	51.0	COG3328@1|root,COG3328@2|Bacteria,1G3YG@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
CMS2_k127_1236322_5	1313421.JHBV01000024_gene4908	1.716e-29	123.0	COG2003@1|root,COG2003@2|Bacteria,4NP8R@976|Bacteroidetes	976|Bacteroidetes	L	RadC-like JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	RadC
CMS2_k127_124079_0	1117108.PAALTS15_22598	0.0	1885.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1242273_1	1122222.AXWR01000044_gene2344	3.107e-14	74.0	COG1373@1|root,COG1373@2|Bacteria,1WIG0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_1242273_0	221288.JH992901_gene4274	2.544e-20	96.0	COG1848@1|root,COG1848@2|Bacteria,1GDWJ@1117|Cyanobacteria,1JM5I@1189|Stigonemataceae	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_1256592_6	118005.AWNK01000004_gene1064	1.106e-250	802.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1256592_9	509191.AEDB02000067_gene916	1.271e-196	628.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_1256592_1	509191.AEDB02000067_gene919	0.0	1480.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1256592_4	509191.AEDB02000067_gene921	2.661e-292	944.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1256592_11	1123229.AUBC01000012_gene2735	1.038e-130	437.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,3JQP1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Domain of unknown function (DUF4070)	MA20_17485	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_1256592_5	1169144.KB910971_gene2149	4.519e-277	901.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	ko:K16093,ko:K16095	ko01054,map01054	-	-	-	ko00000,ko00001	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
CMS2_k127_1256592_10	711393.AYRX01000103_gene5911	1.59e-139	462.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_1256592_0	1408422.JHYF01000017_gene1871	0.0	1988.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1256592_13	289376.THEYE_A1112	9.573e-55	209.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	atoC	-	-	ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_1256592_12	1232437.KL661971_gene4849	6.761e-65	224.0	COG0346@1|root,COG0346@2|Bacteria,1RGGX@1224|Proteobacteria,42RWH@68525|delta/epsilon subdivisions,2WNU6@28221|Deltaproteobacteria,2MNHP@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
CMS2_k127_1256592_15	469618.FVAG_01124	4.498e-08	60.0	COG1145@1|root,COG1145@2|Bacteria,378E8@32066|Fusobacteria	32066|Fusobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
CMS2_k127_1256592_8	909663.KI867149_gene3404	2.838e-205	657.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria,2MREH@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
CMS2_k127_1256592_2	1125863.JAFN01000001_gene1222	1.366e-298	923.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,43CGH@68525|delta/epsilon subdivisions,2WJ3J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EQ	PFAM Hydantoinase B oxoprolinase	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
CMS2_k127_1256592_3	1125863.JAFN01000001_gene1223	4.338e-293	914.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42NFP@68525|delta/epsilon subdivisions,2WK64@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EQ	PFAM Hydantoinase oxoprolinase	hyuA	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
CMS2_k127_1256592_7	589924.Ferp_2331	1.323e-227	716.0	COG1884@1|root,arCOG04232@2157|Archaea,2XU3F@28890|Euryarchaeota,245QJ@183980|Archaeoglobi	2157|Archaea	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
CMS2_k127_1256592_14	1125863.JAFN01000001_gene1225	1.107e-42	160.0	COG2185@1|root,COG2185@2|Bacteria,1N56M@1224|Proteobacteria,42UGU@68525|delta/epsilon subdivisions,2WQDE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
CMS2_k127_1259223_3	118005.AWNK01000004_gene1064	0.0	1110.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1259223_1	1196323.ALKF01000205_gene4114	0.0	1458.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1259223_2	1121121.KB894288_gene2764	0.0	1406.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1259223_0	755731.Clo1100_0890	0.0	2097.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1262735_0	1200792.AKYF01000010_gene2343	0.0	2618.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1263639_0	926556.Echvi_3203	4.392e-63	235.0	COG3385@1|root,COG5421@1|root,COG3385@2|Bacteria,COG5421@2|Bacteria,4NXT2@976|Bacteroidetes	976|Bacteroidetes	L	hmm pf01609	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
CMS2_k127_1266777_41	1198114.AciX9_3497	2.376e-15	79.0	COG3041@1|root,COG3041@2|Bacteria	2|Bacteria	S	endonuclease activity	-	-	-	ko:K19157	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	YafQ_toxin
CMS2_k127_1266777_18	945713.IALB_2951	5.471e-60	222.0	COG1408@1|root,COG1408@2|Bacteria	2|Bacteria	S	Calcineurin-like phosphoesterase	Z012_05430	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
CMS2_k127_1266777_38	748727.CLJU_c23620	1.109e-18	90.0	COG1545@1|root,COG1545@2|Bacteria	2|Bacteria	I	DUF35 OB-fold domain, acyl-CoA-associated	phlB	-	-	ko:K07068,ko:K07549	ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220	M00418	R05587	RC00004,RC01428,RC02904	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF35_N,OB_aCoA_assoc
CMS2_k127_1266777_5	748727.CLJU_c23630	1.299e-142	462.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,24FFI@186801|Clostridia	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS2_k127_1266777_13	748727.CLJU_c23640	8.997e-76	262.0	2ATRB@1|root,31JA4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1266777_6	1047013.AQSP01000062_gene1209	4.676e-134	449.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	XK27_02215	-	3.4.21.96	ko:K01361	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I9,PA,Peptidase_S8,SLH,YSIRK_signal,fn3_5
CMS2_k127_1266777_45	439235.Dalk_1780	1.822e-07	61.0	COG3047@1|root,COG3047@2|Bacteria,1Q8PV@1224|Proteobacteria,437GB@68525|delta/epsilon subdivisions,2X2NY@28221|Deltaproteobacteria,2MP63@213118|Desulfobacterales	2|Bacteria	M	OmpW family	ompW	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K07275,ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	OmpW
CMS2_k127_1266777_21	768670.Calni_0137	1.32e-53	199.0	COG0388@1|root,COG0388@2|Bacteria,2GFA6@200930|Deferribacteres	200930|Deferribacteres	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
CMS2_k127_1266777_10	517418.Ctha_1765	1.182e-88	299.0	COG0171@1|root,COG0171@2|Bacteria,1FDHZ@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
CMS2_k127_1266777_37	439235.Dalk_0783	9.461e-19	89.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,43BIE@68525|delta/epsilon subdivisions,2X6WS@28221|Deltaproteobacteria,2MKKT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS2_k127_1266777_0	330214.NIDE0403	2.008e-223	707.0	COG0441@1|root,COG0441@2|Bacteria,3J0F4@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
CMS2_k127_1266777_28	857293.CAAU_0659	1.481e-40	156.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,36I2Z@31979|Clostridiaceae	186801|Clostridia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
CMS2_k127_1266777_43	1304880.JAGB01000001_gene523	7.097e-14	73.0	COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
CMS2_k127_1266777_29	1047013.AQSP01000119_gene1304	3.109e-40	153.0	COG0292@1|root,COG0292@2|Bacteria,2NPQQ@2323|unclassified Bacteria	2|Bacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
CMS2_k127_1266777_48	649747.HMPREF0083_02301	0.0001491	49.0	COG3027@1|root,COG3027@2|Bacteria,1VFZR@1239|Firmicutes,4HNRI@91061|Bacilli,26QBQ@186822|Paenibacillaceae	91061|Bacilli	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
CMS2_k127_1266777_2	1047013.AQSP01000119_gene1298	6.668e-153	499.0	COG1418@1|root,COG1418@2|Bacteria,2NNU5@2323|unclassified Bacteria	2|Bacteria	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
CMS2_k127_1266777_12	1121430.JMLG01000001_gene2103	7.316e-82	280.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,24967@186801|Clostridia,2604A@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM metallophosphoesterase, MG_246 BB_0505 family	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
CMS2_k127_1266777_14	795359.TOPB45_1248	2.332e-75	274.0	COG2204@1|root,COG2204@2|Bacteria,2GH05@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_1266777_19	1047013.AQSP01000140_gene2498	1.177e-55	208.0	COG1597@1|root,COG1597@2|Bacteria,2NS0F@2323|unclassified Bacteria	2|Bacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
CMS2_k127_1266777_4	1232437.KL662015_gene1247	3.751e-143	482.0	COG2203@1|root,COG2204@1|root,COG3437@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MJ2F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,sCache_2
CMS2_k127_1266777_20	1168034.FH5T_17735	8.893e-55	204.0	COG0642@1|root,COG3437@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,4P2BP@976|Bacteroidetes	976|Bacteroidetes	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS2_k127_1266777_32	1519464.HY22_06230	2.136e-32	130.0	2AD7J@1|root,312WH@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF1987)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1987
CMS2_k127_1266777_33	313606.M23134_04467	7.053e-31	128.0	2DBYH@1|root,2ZBV5@2|Bacteria,4P4TR@976|Bacteroidetes,47VGR@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1266777_24	1499967.BAYZ01000026_gene1619	1.012e-50	192.0	COG2199@1|root,COG3706@2|Bacteria,2NPKY@2323|unclassified Bacteria	2|Bacteria	T	Diguanylate cyclase, GGDEF domain	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,PAS_9,Response_reg
CMS2_k127_1266777_7	641491.DND132_2155	2.892e-117	400.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria,2MH9G@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
CMS2_k127_1266777_36	1047013.AQSP01000133_gene2144	1.881e-23	104.0	COG3437@1|root,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	cheY2	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HD,HD_5,Response_reg
CMS2_k127_1266777_40	1168289.AJKI01000010_gene1576	5.332e-17	86.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4NIEK@976|Bacteroidetes,2FMAP@200643|Bacteroidia,3XIUA@558415|Marinilabiliaceae	976|Bacteroidetes	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_1266777_11	794903.OPIT5_23755	3.861e-86	292.0	COG0179@1|root,COG0179@2|Bacteria,46SDD@74201|Verrucomicrobia,3K7IJ@414999|Opitutae	414999|Opitutae	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
CMS2_k127_1266777_8	573413.Spirs_3098	9.241e-115	386.0	COG0535@1|root,COG0535@2|Bacteria,2J83E@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
CMS2_k127_1266777_9	290512.Paes_1913	5.299e-110	368.0	COG0438@1|root,COG0438@2|Bacteria,1FEE3@1090|Chlorobi	1090|Chlorobi	H	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_1266777_30	744872.Spica_2162	5.923e-39	154.0	COG2454@1|root,COG2454@2|Bacteria,2JADQ@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF434)	-	-	-	-	-	-	-	-	-	-	-	-	DUF434
CMS2_k127_1266777_26	1232410.KI421428_gene1010	7.738e-44	163.0	COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,42SID@68525|delta/epsilon subdivisions,2WQ86@28221|Deltaproteobacteria,43SGS@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	nickel-responsive regulator	nikR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
CMS2_k127_1266777_15	1408473.JHXO01000001_gene2181	8.937e-72	265.0	COG4206@1|root,COG4206@2|Bacteria,4NHH8@976|Bacteroidetes,2FM70@200643|Bacteroidia	976|Bacteroidetes	H	COG COG4771 Outer membrane receptor for ferrienterochelin and colicins	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
CMS2_k127_1266777_35	1195236.CTER_0504	3.326e-24	109.0	298ZI@1|root,2ZW3A@2|Bacteria,1V7FU@1239|Firmicutes,24ID8@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K16788	-	-	-	-	ko00000,ko02000	2.A.88.5	-	-	ECF_trnsprt
CMS2_k127_1266777_31	485916.Dtox_0549	1.689e-36	145.0	COG0500@1|root,COG2226@2|Bacteria,1V6EF@1239|Firmicutes,24JZ4@186801|Clostridia,262N8@186807|Peptococcaceae	186801|Clostridia	Q	PFAM methyltransferase	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS2_k127_1266777_42	580331.Thit_0210	5.526e-14	81.0	COG0619@1|root,COG0619@2|Bacteria,1V6BC@1239|Firmicutes,24BI0@186801|Clostridia,42FKC@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM Cobalt transport protein	-	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
CMS2_k127_1266777_44	555779.Dthio_PD2253	1.611e-09	63.0	COG1672@1|root,COG1672@2|Bacteria,1N4VD@1224|Proteobacteria,42Y71@68525|delta/epsilon subdivisions,2WTK1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Predicted AAA-ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,PDDEXK_9
CMS2_k127_1266777_27	351160.RRC456	4.337e-42	170.0	COG3263@1|root,arCOG01962@2157|Archaea	2157|Archaea	P	Sodium hydrogen exchanger	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
CMS2_k127_1266777_1	1121405.dsmv_1573	1.496e-220	699.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,42N91@68525|delta/epsilon subdivisions,2WIMM@28221|Deltaproteobacteria,2MIKE@213118|Desulfobacterales	28221|Deltaproteobacteria	J	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
CMS2_k127_1266777_3	215803.DB30_1529	2.433e-144	473.0	COG2304@1|root,COG2304@2|Bacteria,1R8EZ@1224|Proteobacteria,433AE@68525|delta/epsilon subdivisions,2WYFQ@28221|Deltaproteobacteria,2YY3M@29|Myxococcales	28221|Deltaproteobacteria	S	IgA Peptidase M64	-	-	-	-	-	-	-	-	-	-	-	-	M64_N,Peptidase_M64
CMS2_k127_1266777_23	4538.ORGLA04G0259200.1	1.12e-51	204.0	COG0500@1|root,KOG1499@2759|Eukaryota,37JCP@33090|Viridiplantae,3G8BY@35493|Streptophyta,3KYH9@4447|Liliopsida,3I8Y6@38820|Poales	35493|Streptophyta	KOT	Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006325,GO:0006355,GO:0006464,GO:0006479,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008469,GO:0008757,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016043,GO:0016273,GO:0016274,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018193,GO:0018195,GO:0018216,GO:0019219,GO:0019222,GO:0019538,GO:0019919,GO:0031323,GO:0031326,GO:0032259,GO:0034969,GO:0035242,GO:0035246,GO:0035247,GO:0036211,GO:0042054,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051276,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141	2.1.1.319	ko:K11437	-	-	R11216,R11217,R11219	RC00003,RC02120,RC03388,RC03390	ko00000,ko01000,ko03036	-	-	-	Methyltransf_25,PrmA
CMS2_k127_1266777_17	883078.HMPREF9695_00529	3.923e-64	228.0	COG3233@1|root,COG3233@2|Bacteria,1NEVW@1224|Proteobacteria,2UKF4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2334)	-	-	-	ko:K06986	-	-	-	-	ko00000	-	-	-	DUF2334
CMS2_k127_1266777_16	883078.HMPREF9695_00528	1.441e-70	253.0	COG0438@1|root,COG0438@2|Bacteria,1NU0D@1224|Proteobacteria,2U2M4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	ko:K14335	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_1266777_34	313606.M23134_02113	1.92e-28	127.0	COG0526@1|root,COG0526@2|Bacteria,4NEX3@976|Bacteroidetes,47JZP@768503|Cytophagia	976|Bacteroidetes	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	ccmG	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF4369
CMS2_k127_1266777_47	330214.NIDE4090	5.491e-05	54.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,HYR,Laminin_G_3,RHS_repeat,SprB
CMS2_k127_1266777_46	28072.Nos7524_2009	4.345e-05	54.0	COG2304@1|root,COG3209@1|root,COG4932@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,COG4932@2|Bacteria,1GPZZ@1117|Cyanobacteria,1HJUW@1161|Nostocales	1117|Cyanobacteria	M	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,VWA
CMS2_k127_1266777_22	243231.GSU1066	1.327e-52	214.0	COG2304@1|root,COG3419@1|root,COG2304@2|Bacteria,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WKJV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,PA14
CMS2_k127_1266777_49	1033802.SSPSH_003246	0.0001724	51.0	COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,1SCFB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	COG4970 Tfp pilus assembly protein FimT	-	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
CMS2_k127_1266777_25	1125863.JAFN01000001_gene1806	6.489e-49	180.0	COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,42SJF@68525|delta/epsilon subdivisions,2WP4X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS2_k127_1266777_39	1227352.C173_07337	4.913e-17	95.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4HUAW@91061|Bacilli,26QAC@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter substrate-binding protein	XK27_07260	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS2_k127_1278223_0	1340493.JNIF01000003_gene1477	1.869e-55	207.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	ko:K20333	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	FGE-sulfatase,NACHT
CMS2_k127_1278223_1	667015.Bacsa_2367	0.0005693	43.0	COG5464@1|root,COG5464@2|Bacteria,4NJT2@976|Bacteroidetes,2FQ31@200643|Bacteroidia,4AW7W@815|Bacteroidaceae	976|Bacteroidetes	S	PD-(D/E)XK nuclease family transposase	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_1285022_44	1304284.L21TH_1709	1.948e-12	70.0	2C5U6@1|root,330NX@2|Bacteria,1VGSI@1239|Firmicutes,24STB@186801|Clostridia,36TE0@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1285022_32	1267533.KB906742_gene658	1.488e-32	139.0	COG2208@1|root,COG2208@2|Bacteria,3Y6VQ@57723|Acidobacteria,2JKZZ@204432|Acidobacteriia	204432|Acidobacteriia	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
CMS2_k127_1285022_36	1123037.AUDE01000053_gene3189	4.667e-24	113.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
CMS2_k127_1285022_24	1047013.AQSP01000138_gene1052	1.47e-66	236.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	waaE	-	-	ko:K12984	-	-	-	-	ko00000,ko01000,ko01003,ko01005,ko02000	4.D.1.3	GT2	-	Glyco_transf_7C,Glycos_transf_2
CMS2_k127_1285022_42	931276.Cspa_c45300	5.136e-16	89.0	COG3980@1|root,COG3980@2|Bacteria,1U2ZW@1239|Firmicutes,24HWM@186801|Clostridia,36G5R@31979|Clostridiaceae	186801|Clostridia	M	pseudaminic acid biosynthesis-associated protein PseG	pseG	-	3.6.1.57	ko:K15897	ko00520,map00520	-	R09834	RC00005,RC00078	ko00000,ko00001,ko01000	-	-	-	Glyco_tran_28_C
CMS2_k127_1285022_15	1506583.JQJY01000005_gene2341	1.046e-87	304.0	COG1134@1|root,COG1134@2|Bacteria,4NEDM@976|Bacteroidetes,1HXJV@117743|Flavobacteriia,2NT6Z@237|Flavobacterium	976|Bacteroidetes	GM	ABC-type polysaccharide polyol phosphate transport system, ATPase component	rfbB	-	-	ko:K01990,ko:K09691	ko02010,map02010	M00250,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103	-	-	ABC_tran,Wzt_C
CMS2_k127_1285022_19	28072.Nos7524_2131	7.835e-79	273.0	COG1682@1|root,COG1682@2|Bacteria,1G234@1117|Cyanobacteria,1HMJ2@1161|Nostocales	1117|Cyanobacteria	GM	ABC-type polysaccharide polyol phosphate export systems permease component	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
CMS2_k127_1285022_41	697303.Thewi_0767	4.548e-17	84.0	arCOG07672@1|root,32Z5Y@2|Bacteria,1VG6R@1239|Firmicutes,24T0M@186801|Clostridia,42H3E@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF4258)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4258
CMS2_k127_1285022_38	472759.Nhal_2933	2.222e-19	90.0	2B9W9@1|root,3239G@2|Bacteria,1P6V9@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1285022_12	439235.Dalk_1668	2.835e-116	389.0	COG1083@1|root,COG1216@1|root,COG1083@2|Bacteria,COG1216@2|Bacteria,1PFY9@1224|Proteobacteria,437C1@68525|delta/epsilon subdivisions,2XA0C@28221|Deltaproteobacteria,2MPDT@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_1285022_17	502025.Hoch_6157	2.399e-81	282.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,42SXH@68525|delta/epsilon subdivisions,2WP5D@28221|Deltaproteobacteria,2Z1FP@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.1.1.338	ko:K16844	ko00270,ko01120,map00270,map01120	-	R07137	RC00031	ko00000,ko00001,ko01000	-	-	-	Ldh_2
CMS2_k127_1285022_31	1121104.AQXH01000003_gene323	1.412e-41	164.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.265	ko:K16868	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS2_k127_1285022_33	179408.Osc7112_2814	2.594e-30	137.0	COG0515@1|root,COG0666@1|root,COG0515@2|Bacteria,COG0666@2|Bacteria,1G1JA@1117|Cyanobacteria,1HACD@1150|Oscillatoriales	1117|Cyanobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_4,Pkinase
CMS2_k127_1285022_26	1047013.AQSP01000051_gene2576	1.775e-59	226.0	COG2220@1|root,COG2220@2|Bacteria,2NRBH@2323|unclassified Bacteria	2|Bacteria	S	Beta-lactamase superfamily domain	folD4	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CMS2_k127_1285022_13	756067.MicvaDRAFT_2831	1.837e-114	376.0	arCOG10456@1|root,2ZA6T@2|Bacteria,1G2PI@1117|Cyanobacteria,1HBZF@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1285022_5	880073.Calab_0652	8.113e-161	512.0	COG0604@1|root,COG0604@2|Bacteria,2NQR7@2323|unclassified Bacteria	2|Bacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
CMS2_k127_1285022_43	338969.Rfer_1769	1.075e-12	70.0	arCOG10456@1|root,2ZA6T@2|Bacteria,1R4VS@1224|Proteobacteria,2VQRB@28216|Betaproteobacteria,4AIFM@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1285022_21	338969.Rfer_1769	2.088e-75	263.0	arCOG10456@1|root,2ZA6T@2|Bacteria,1R4VS@1224|Proteobacteria,2VQRB@28216|Betaproteobacteria,4AIFM@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1285022_2	509191.AEDB02000067_gene916	2.956e-198	632.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_1285022_8	313603.FB2170_11916	2.75e-140	472.0	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,1HZHJ@117743|Flavobacteriia,2PIWB@252356|Maribacter	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_1285022_14	545695.TREAZ_2741	2.072e-111	366.0	COG3509@1|root,COG3509@2|Bacteria,2J9JG@203691|Spirochaetes	203691|Spirochaetes	Q	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1285022_4	313606.M23134_07246	8.038e-186	621.0	COG2203@1|root,COG2208@1|root,COG3292@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3292@2|Bacteria,4NKGA@976|Bacteroidetes,47TQU@768503|Cytophagia	976|Bacteroidetes	T	Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,SpoIIE,Y_Y_Y
CMS2_k127_1285022_53	1540257.JQMW01000008_gene2626	0.0006473	47.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,36E8H@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,NUDIX,PqqD,Radical_SAM,SPASM
CMS2_k127_1285022_18	357809.Cphy_3574	2.026e-80	284.0	COG1032@1|root,COG1032@2|Bacteria,1W799@1239|Firmicutes,258NB@186801|Clostridia,22308@1506553|Lachnoclostridium	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_1285022_35	1121405.dsmv_1230	1.965e-25	119.0	COG3746@1|root,COG3746@2|Bacteria,1QXPF@1224|Proteobacteria,42TW0@68525|delta/epsilon subdivisions,2WQ4G@28221|Deltaproteobacteria,2MNVB@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
CMS2_k127_1285022_10	641491.DND132_0618	3.406e-126	414.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,2M9GZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
CMS2_k127_1285022_40	382464.ABSI01000006_gene900	4.483e-18	87.0	COG1862@1|root,COG1862@2|Bacteria,46T88@74201|Verrucomicrobia,2IUY8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	U	Preprotein translocase subunit	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
CMS2_k127_1285022_6	1047013.AQSP01000034_gene1652	1.004e-154	504.0	COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
CMS2_k127_1285022_25	1267533.KB906734_gene4323	1.101e-61	228.0	COG0341@1|root,COG0341@2|Bacteria,3Y2ZT@57723|Acidobacteria,2JHZF@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
CMS2_k127_1285022_27	1047013.AQSP01000079_gene2043	9.14e-56	203.0	COG0810@1|root,COG0810@2|Bacteria,2NQ1D@2323|unclassified Bacteria	2|Bacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,TonB_C
CMS2_k127_1285022_28	1340493.JNIF01000003_gene1848	5.133e-54	197.0	COG0811@1|root,COG0811@2|Bacteria,3Y2M4@57723|Acidobacteria	57723|Acidobacteria	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
CMS2_k127_1285022_37	1047013.AQSP01000011_gene275	1.225e-20	97.0	COG0848@1|root,COG0848@2|Bacteria,2NPWJ@2323|unclassified Bacteria	2|Bacteria	U	Biopolymer transport protein ExbD/TolR	tolR	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
CMS2_k127_1285022_30	743722.Sph21_1578	2.297e-43	170.0	COG1597@1|root,COG1597@2|Bacteria,4NJWB@976|Bacteroidetes,1IQ8Q@117747|Sphingobacteriia	976|Bacteroidetes	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
CMS2_k127_1285022_29	387631.Asulf_02259	1.627e-51	186.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,2465T@183980|Archaeoglobi	183980|Archaeoglobi	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
CMS2_k127_1285022_7	1349785.BAUG01000006_gene599	7.932e-146	471.0	COG0075@1|root,COG0075@2|Bacteria,4NH61@976|Bacteroidetes,1HY2N@117743|Flavobacteriia	976|Bacteroidetes	E	Aminotransferase class-V	phnW	-	2.6.1.37,2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830,ko:K03430	ko00250,ko00260,ko00440,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00440,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588,R04152	RC00006,RC00008,RC00018,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
CMS2_k127_1285022_48	1370121.AUWS01000080_gene750	5.221e-06	56.0	28R8P@1|root,2ZDNC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1285022_11	946077.W5A_01240	8.228e-119	391.0	COG1446@1|root,COG1446@2|Bacteria,4NF1U@976|Bacteroidetes,1HXC4@117743|Flavobacteriia	976|Bacteroidetes	E	asparaginase	iaaA	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
CMS2_k127_1285022_20	1121447.JONL01000004_gene2732	4.738e-77	272.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,42UR3@68525|delta/epsilon subdivisions,2WQQQ@28221|Deltaproteobacteria,2M7TS@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
CMS2_k127_1285022_16	886293.Sinac_6637	8.568e-84	289.0	COG1163@1|root,COG1163@2|Bacteria,2IWYP@203682|Planctomycetes	203682|Planctomycetes	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
CMS2_k127_1285022_51	1205683.CAKR01000017_gene942	0.0001057	49.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,41G7W@629|Yersinia	1236|Gammaproteobacteria	U	general secretion pathway protein G	gspG	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
CMS2_k127_1285022_39	1047013.AQSP01000084_gene773	1.655e-18	91.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
CMS2_k127_1285022_9	880073.Calab_2784	2.997e-134	448.0	COG1164@1|root,COG1164@2|Bacteria,2NQ8K@2323|unclassified Bacteria	2|Bacteria	E	Oligoendopeptidase f	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2,Peptidase_M3
CMS2_k127_1285022_50	1047013.AQSP01000021_gene1229	9.168e-05	54.0	2DH1X@1|root,2ZY43@2|Bacteria	1047013.AQSP01000021_gene1229|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1285022_46	748247.AZKH_2142	2.293e-06	52.0	2EK17@1|root,33DRQ@2|Bacteria,1NNYN@1224|Proteobacteria,2W3GN@28216|Betaproteobacteria,2KYZR@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1285022_47	1232437.KL662005_gene4314	2.597e-06	53.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS,Ub-Mut7C
CMS2_k127_1285022_0	1232437.KL661965_gene3270	0.0	1113.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MJNF@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS2_k127_1285022_22	1232437.KL661965_gene3271	3.465e-69	238.0	COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,42TQV@68525|delta/epsilon subdivisions,2WQAE@28221|Deltaproteobacteria,2MKXW@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,Fer4_7
CMS2_k127_1285022_1	1124780.ANNU01000036_gene34	1.082e-245	779.0	COG0531@1|root,COG0531@2|Bacteria,4NFFX@976|Bacteroidetes,47M9P@768503|Cytophagia	976|Bacteroidetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease
CMS2_k127_1285022_45	1120985.AUMI01000011_gene512	1.223e-06	63.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,4H20Y@909932|Negativicutes	909932|Negativicutes	D	Belongs to the SEDS family	spoVE	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
CMS2_k127_1285022_49	158787.BSCA_0206	5.21e-05	57.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,4CYTI@85004|Bifidobacteriales	201174|Actinobacteria	M	penicillin-binding protein	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
CMS2_k127_1285022_23	391165.GbCGDNIH1_0237	1.291e-67	237.0	COG1213@1|root,COG1213@2|Bacteria,1RKR2@1224|Proteobacteria,2U97V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	MobA-like NTP transferase domain	-	-	2.7.7.74	ko:K07281	ko00562,map00562	-	R09669	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS2_k127_1285022_3	459349.CLOAM0423	2.65e-191	606.0	COG1260@1|root,COG1260@2|Bacteria,2NP2I@2323|unclassified Bacteria	2|Bacteria	I	Myo-inositol-1-phosphate synthase	ino1	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
CMS2_k127_1293590_0	1293054.HSACCH_01095	7.841e-38	151.0	COG0491@1|root,COG0491@2|Bacteria,1VHDZ@1239|Firmicutes,24RUW@186801|Clostridia	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_1296527_0	1041146.ATZB01000058_gene4176	9.652e-61	220.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,TPR_16,TPR_19,TPR_2,TPR_8
CMS2_k127_1304588_29	1313421.JHBV01000024_gene4908	7.89e-55	200.0	COG2003@1|root,COG2003@2|Bacteria,4NP8R@976|Bacteroidetes	976|Bacteroidetes	L	RadC-like JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	RadC
CMS2_k127_1304588_43	163908.KB235896_gene3289	9.049e-27	111.0	COG2442@1|root,COG2442@2|Bacteria	2|Bacteria	K	InterPro IPR007367	-	-	-	-	-	-	-	-	-	-	-	-	DUF433,MerR_1
CMS2_k127_1304588_44	518766.Rmar_0428	8.555e-25	108.0	COG4634@1|root,COG4634@2|Bacteria,4NZ31@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1304588_50	370438.PTH_2792	1.167e-11	72.0	COG1848@1|root,COG1848@2|Bacteria,1VVM9@1239|Firmicutes,250X5@186801|Clostridia	186801|Clostridia	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_1304588_3	247490.KSU1_B0601	4.963e-203	655.0	COG0464@1|root,COG0464@2|Bacteria,2IYYC@203682|Planctomycetes	203682|Planctomycetes	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS2_k127_1304588_40	195250.CM001776_gene2906	3.812e-35	145.0	28RC2@1|root,3303J@2|Bacteria,1GRAG@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF4255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4255
CMS2_k127_1304588_5	1501230.ET33_31625	5.273e-162	532.0	COG3497@1|root,COG3497@2|Bacteria,1TNY8@1239|Firmicutes,4HCQV@91061|Bacilli,26S6A@186822|Paenibacillaceae	91061|Bacilli	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
CMS2_k127_1304588_26	243231.GSU0976	9.688e-58	204.0	2BEKE@1|root,328BU@2|Bacteria,1RM2J@1224|Proteobacteria,42TNQ@68525|delta/epsilon subdivisions,2WQG6@28221|Deltaproteobacteria,43VX9@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
CMS2_k127_1304588_35	913865.DOT_6091	4.454e-46	168.0	arCOG11412@1|root,31S84@2|Bacteria,1V6H1@1239|Firmicutes,24K0T@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1304588_48	1200792.AKYF01000018_gene5792	1.621e-18	87.0	arCOG11411@1|root,33A8Q@2|Bacteria,1VM7Z@1239|Firmicutes,4HR18@91061|Bacilli,2744P@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1304588_27	118161.KB235920_gene5975	1.206e-57	203.0	2DMQT@1|root,32T2H@2|Bacteria,1G73M@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
CMS2_k127_1304588_25	913865.DOT_6088	6.57e-61	218.0	COG1652@1|root,COG1652@2|Bacteria,1V83T@1239|Firmicutes,24KBD@186801|Clostridia	186801|Clostridia	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
CMS2_k127_1304588_23	243231.GSU0982	3.131e-72	257.0	COG3500@1|root,COG3500@2|Bacteria,1R67C@1224|Proteobacteria,42VHB@68525|delta/epsilon subdivisions,2WS22@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Phage late control gene D protein (GPD)	-	-	-	ko:K06905	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_1304588_18	913865.DOT_6085	6.553e-90	302.0	COG3501@1|root,COG3501@2|Bacteria,1V234@1239|Firmicutes,24MBD@186801|Clostridia	186801|Clostridia	S	Rhs element vgr protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_base_V
CMS2_k127_1304588_36	913865.DOT_6084	9.347e-44	161.0	COG4104@1|root,COG4104@2|Bacteria	2|Bacteria	T	PAAR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PAAR_motif
CMS2_k127_1304588_33	913865.DOT_6083	3.19e-50	182.0	COG3628@1|root,COG3628@2|Bacteria,1VCD7@1239|Firmicutes,24P2S@186801|Clostridia	186801|Clostridia	S	Gene 25-like lysozyme	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
CMS2_k127_1304588_8	913865.DOT_6082	8.868e-132	467.0	COG3299@1|root,COG3299@2|Bacteria,1TRCX@1239|Firmicutes,24BAX@186801|Clostridia	186801|Clostridia	T	homolog of phage Mu protein gp47	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
CMS2_k127_1304588_14	913865.DOT_6081	1.557e-112	391.0	COG3299@1|root,COG3299@2|Bacteria,1UH8J@1239|Firmicutes,24GEV@186801|Clostridia	186801|Clostridia	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
CMS2_k127_1304588_19	913865.DOT_6080	2.071e-82	297.0	COG3391@1|root,COG4385@1|root,COG3391@2|Bacteria,COG4385@2|Bacteria,1UZ1H@1239|Firmicutes,24I7Q@186801|Clostridia	186801|Clostridia	S	Tail protein	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
CMS2_k127_1304588_34	243231.GSU0990	2.003e-47	194.0	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Haemagg_act,TIG
CMS2_k127_1304588_51	469618.FVAG_02569	4.02e-07	61.0	COG0859@1|root,COG0859@2|Bacteria,378YY@32066|Fusobacteria	32066|Fusobacteria	M	heptosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
CMS2_k127_1304588_41	1121472.AQWN01000008_gene2020	3.826e-30	140.0	COG0438@1|root,COG0438@2|Bacteria,1UHSF@1239|Firmicutes,25EAY@186801|Clostridia,261D9@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_1304588_28	1446473.JHWH01000014_gene2647	1.889e-57	229.0	COG0438@1|root,COG2723@1|root,COG0438@2|Bacteria,COG2723@2|Bacteria,1MWU7@1224|Proteobacteria,2V86A@28211|Alphaproteobacteria,2PYEE@265|Paracoccus	28211|Alphaproteobacteria	GM	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1304588_32	526222.Desal_1058	7.025e-51	208.0	COG0535@1|root,COG0535@2|Bacteria,1RG5U@1224|Proteobacteria,42RKR@68525|delta/epsilon subdivisions,2WNUX@28221|Deltaproteobacteria,2MAGK@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
CMS2_k127_1304588_6	666686.B1NLA3E_12830	5.784e-151	500.0	COG1032@1|root,COG1032@2|Bacteria,1VFTA@1239|Firmicutes	1239|Firmicutes	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_1304588_37	909663.KI867151_gene3070	3.069e-43	177.0	COG3064@1|root,COG3064@2|Bacteria,1QW8P@1224|Proteobacteria	1224|Proteobacteria	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,Ntox15
CMS2_k127_1304588_45	398580.Dshi_2549	1.171e-21	111.0	COG3409@1|root,COG3409@2|Bacteria,1R00V@1224|Proteobacteria	1224|Proteobacteria	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
CMS2_k127_1304588_42	237368.SCABRO_00848	8.017e-28	131.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,PG_binding_1
CMS2_k127_1304588_47	1330700.JQNC01000003_gene1881	3.332e-20	106.0	COG0791@1|root,COG1388@1|root,COG0791@2|Bacteria,COG1388@2|Bacteria,1WJI4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Cell wall-associated hydrolase (invasion-associated protein)	-	-	-	-	-	-	-	-	-	-	-	-	LysM,NLPC_P60
CMS2_k127_1304588_21	665571.STHERM_c12870	2.169e-74	254.0	COG4657@1|root,COG4657@2|Bacteria,2J5ES@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
CMS2_k127_1304588_20	1307761.L21SP2_0451	1.33e-77	265.0	COG4660@1|root,COG4660@2|Bacteria,2J58U@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rsxE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
CMS2_k127_1304588_38	1121904.ARBP01000002_gene6740	2.116e-42	162.0	COG4659@1|root,COG4659@2|Bacteria,4NQKH@976|Bacteroidetes	976|Bacteroidetes	C	Part of a membrane complex involved in electron transport	rnfG	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
CMS2_k127_1304588_10	665571.STHERM_c12840	1.482e-119	394.0	COG4658@1|root,COG4658@2|Bacteria,2J639@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
CMS2_k127_1304588_4	869213.JCM21142_93460	1.782e-170	548.0	COG4656@1|root,COG4656@2|Bacteria,4NIS7@976|Bacteroidetes	976|Bacteroidetes	C	Part of a membrane complex involved in electron transport	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_17,Fer4_7,RnfC_N,SLBB
CMS2_k127_1304588_13	1480694.DC28_06665	4.45e-117	383.0	COG1148@1|root,COG2878@1|root,COG1148@2|Bacteria,COG2878@2|Bacteria,2J5VT@203691|Spirochaetes	203691|Spirochaetes	C	electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_9
CMS2_k127_1304588_46	1122981.AUME01000002_gene2215	3.315e-20	96.0	COG3086@1|root,COG3086@2|Bacteria,4NV0R@976|Bacteroidetes,2FS4Y@200643|Bacteroidia	976|Bacteroidetes	T	Positive regulator of sigma(E), RseC MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
CMS2_k127_1304588_1	1047013.AQSP01000106_gene1765	3.432e-226	705.0	COG1509@1|root,COG1509@2|Bacteria,2NNY6@2323|unclassified Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	kamA	-	5.4.3.2,5.4.3.9	ko:K01843,ko:K19810,ko:K19814	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000,ko03012	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
CMS2_k127_1304588_7	1047013.AQSP01000106_gene1766	3.317e-133	435.0	COG0624@1|root,COG0624@2|Bacteria,2NPIK@2323|unclassified Bacteria	2|Bacteria	E	Peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS2_k127_1304588_2	1229909.NSED_07410	1.877e-204	659.0	COG0189@1|root,COG0624@1|root,arCOG01107@2157|Archaea,arCOG01589@2157|Archaea	2157|Archaea	HJ	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	rimK	-	3.4.17.11,3.5.1.18,6.3.2.2,6.3.2.4	ko:K01295,ko:K01439,ko:K01919,ko:K01921,ko:K05844	ko00270,ko00300,ko00473,ko00480,ko00550,ko01100,ko01120,ko01230,ko01502,map00270,map00300,map00473,map00480,map00550,map01100,map01120,map01230,map01502	M00016,M00118	R00894,R01150,R02734,R10993	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko03009	-	-	-	M20_dimer,Peptidase_M20,RimK
CMS2_k127_1304588_12	497965.Cyan7822_5069	2.906e-117	394.0	COG0477@1|root,COG2814@2|Bacteria,1GQ8C@1117|Cyanobacteria,3KJN6@43988|Cyanothece	1117|Cyanobacteria	P	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS2_k127_1304588_30	1443665.JACA01000019_gene4838	1.628e-53	200.0	COG0823@1|root,COG0823@2|Bacteria,4NIV7@976|Bacteroidetes,1HYWC@117743|Flavobacteriia,2YI86@290174|Aquimarina	976|Bacteroidetes	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
CMS2_k127_1304588_31	945713.IALB_0831	6.573e-52	209.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbU	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,GAF_3,SpoIIE
CMS2_k127_1304588_39	1265505.ATUG01000002_gene2500	5.346e-41	155.0	COG0016@1|root,COG0016@2|Bacteria,1NVRM@1224|Proteobacteria,4307G@68525|delta/epsilon subdivisions,2WVF3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1304588_24	635013.TherJR_0025	5.192e-70	250.0	COG2423@1|root,COG2423@2|Bacteria	2|Bacteria	E	ornithine cyclodeaminase activity	ocd	-	1.5.1.51,2.5.1.140,4.3.1.12	ko:K01750,ko:K16182,ko:K21721,ko:K21949	ko00300,ko00330,ko01110,ko01120,ko01130,ko01230,map00300,map00330,map01110,map01120,map01130,map01230	-	R00671,R10012,R11705	RC00062,RC00354	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS00720	OCD_Mu_crystall
CMS2_k127_1304588_15	1487923.DP73_19685	1.394e-111	375.0	COG2232@1|root,COG2232@2|Bacteria,1UK0S@1239|Firmicutes,25FGN@186801|Clostridia,267HC@186807|Peptococcaceae	186801|Clostridia	S	Pyrrolysine biosynthesis protein PylC	-	-	-	ko:K16181	ko00300,ko01120,map00300,map01120	-	R10011	RC00096,RC00141	ko00000,ko00001	-	-	-	ATP-grasp_3
CMS2_k127_1304588_9	177437.HRM2_15240	9.756e-121	398.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,42NGR@68525|delta/epsilon subdivisions,2WIMA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6,5.4.99.58	ko:K01012,ko:K16180	ko00300,ko00780,ko01100,ko01120,map00300,map00780,map01100,map01120	M00123,M00573,M00577	R01078,R10010	RC00441,RC02995	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1582	BATS,Radical_SAM
CMS2_k127_1304588_17	398512.JQKC01000008_gene846	4.866e-95	319.0	COG0441@1|root,COG0441@2|Bacteria,1V041@1239|Firmicutes,24BS9@186801|Clostridia	186801|Clostridia	J	PFAM tRNA synthetase class II	-	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
CMS2_k127_1304588_49	945713.IALB_1819	3.135e-17	90.0	COG1410@1|root,COG1410@2|Bacteria	2|Bacteria	E	methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_synt_B12
CMS2_k127_1304588_11	1047013.AQSP01000134_gene1338	7.626e-118	398.0	COG5598@1|root,COG5598@2|Bacteria,2NQTC@2323|unclassified Bacteria	2|Bacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
CMS2_k127_1304588_52	502025.Hoch_3643	2.058e-06	59.0	COG0455@1|root,COG0484@1|root,COG1426@1|root,COG0455@2|Bacteria,COG0484@2|Bacteria,COG1426@2|Bacteria,1R8IW@1224|Proteobacteria,42R3H@68525|delta/epsilon subdivisions,2WMNY@28221|Deltaproteobacteria,2YUZU@29|Myxococcales	28221|Deltaproteobacteria	D	NUBPL iron-transfer P-loop NTPase	-	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,HTH_25,ParA
CMS2_k127_1304588_22	398767.Glov_3238	3.507e-74	260.0	COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42R3H@68525|delta/epsilon subdivisions,2WMNY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	CobQ CobB MinD ParA nucleotide binding	-	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,HTH_25,ParA
CMS2_k127_1304588_0	1121904.ARBP01000010_gene2369	1.704e-262	825.0	COG1331@1|root,COG1331@2|Bacteria,4NFE2@976|Bacteroidetes,47M2A@768503|Cytophagia	976|Bacteroidetes	O	COGs COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
CMS2_k127_1308889_10	526222.Desal_1790	1.686e-95	328.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,42PZ3@68525|delta/epsilon subdivisions,2WJU4@28221|Deltaproteobacteria,2MG5I@213115|Desulfovibrionales	28221|Deltaproteobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_1308889_2	595460.RRSWK_02559	9.722e-165	540.0	COG0845@1|root,COG0845@2|Bacteria,2IZ22@203682|Planctomycetes	203682|Planctomycetes	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	DUF3347,HlyD_D23
CMS2_k127_1308889_0	641491.DND132_1936	0.0	1733.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,43EBY@68525|delta/epsilon subdivisions,2X7W0@28221|Deltaproteobacteria,2MHDJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
CMS2_k127_1308889_6	671143.DAMO_0158	9.268e-138	472.0	COG4409@1|root,COG4409@2|Bacteria,2NQRQ@2323|unclassified Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	nanA	GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Gram_pos_anchor,Sialidase,YSIRK_signal
CMS2_k127_1308889_14	56110.Oscil6304_4436	4.053e-37	155.0	COG3409@1|root,COG3757@1|root,COG3409@2|Bacteria,COG3757@2|Bacteria,1G3TT@1117|Cyanobacteria,1H8M4@1150|Oscillatoriales	1117|Cyanobacteria	M	SMART Glycoside hydrolase, family 25 subgroup	-	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25,PG_binding_1
CMS2_k127_1308889_9	1121920.AUAU01000004_gene672	2.892e-106	354.0	COG3342@1|root,COG3342@2|Bacteria,3Y80E@57723|Acidobacteria	57723|Acidobacteria	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028
CMS2_k127_1308889_3	378806.STAUR_6405	1.429e-157	511.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2YUMA@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
CMS2_k127_1308889_8	177437.HRM2_12020	9.524e-128	423.0	COG3023@1|root,COG3023@2|Bacteria,1PD4C@1224|Proteobacteria,42PQW@68525|delta/epsilon subdivisions,2WK9V@28221|Deltaproteobacteria,2MI3K@213118|Desulfobacterales	28221|Deltaproteobacteria	V	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
CMS2_k127_1308889_15	1444711.CCJF01000003_gene60	1.902e-28	130.0	COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria	2|Bacteria	L	DNA primase activity	-	-	3.6.4.12	ko:K02314,ko:K02316,ko:K17680	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03029,ko03032	-	-	-	AAA_25,DnaB_C,Toprim_2,Toprim_N,zf-CHC2
CMS2_k127_1308889_12	1415775.U729_125	2.628e-60	211.0	COG0756@1|root,COG0756@2|Bacteria,1V6EC@1239|Firmicutes,25CJ6@186801|Clostridia,36WWZ@31979|Clostridiaceae	186801|Clostridia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
CMS2_k127_1308889_7	84531.JMTZ01000011_gene3120	3.554e-135	447.0	COG3227@1|root,COG4935@1|root,COG3227@2|Bacteria,COG4935@2|Bacteria,1P416@1224|Proteobacteria,1RR7I@1236|Gammaproteobacteria,1X4PD@135614|Xanthomonadales	135614|Xanthomonadales	E	Zinc metalloprotease (Elastase)	-	-	3.4.24.25,3.4.24.26	ko:K01399,ko:K08604	ko01503,ko02024,ko05110,ko05111,map01503,map02024,map05110,map05111	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PPC,P_proprotein,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_1308889_5	502025.Hoch_6312	3.063e-140	462.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_1308889_4	502025.Hoch_1667	1.832e-146	479.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_1308889_1	344747.PM8797T_27914	3.805e-292	921.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,2IXGZ@203682|Planctomycetes	203682|Planctomycetes	M	cyanophycin synthetase	-	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
CMS2_k127_1308889_11	570952.ATVH01000015_gene1481	1.141e-73	261.0	COG4242@1|root,COG4242@2|Bacteria,1PR9J@1224|Proteobacteria,2U4I8@28211|Alphaproteobacteria,2JVEW@204441|Rhodospirillales	204441|Rhodospirillales	PQ	Peptidase family S51	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
CMS2_k127_1308889_16	588581.Cpap_2591	1.661e-27	121.0	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia	186801|Clostridia	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_1312385_5	925775.XVE_3843	1.273e-08	64.0	2DB8R@1|root,2Z7SP@2|Bacteria,1MX0M@1224|Proteobacteria,1SI41@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1312385_4	1492737.FEM08_35120	2.238e-18	87.0	COG4913@1|root,COG4913@2|Bacteria,4NFA3@976|Bacteroidetes	976|Bacteroidetes	S	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
CMS2_k127_1312385_3	1121859.KB890757_gene1571	1.53e-24	108.0	COG4913@1|root,COG4913@2|Bacteria,4NFA3@976|Bacteroidetes	976|Bacteroidetes	S	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
CMS2_k127_1312385_6	398767.Glov_0694	6.212e-05	48.0	COG4980@1|root,COG4980@2|Bacteria,1NB49@1224|Proteobacteria,42W0M@68525|delta/epsilon subdivisions,2WRVH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
CMS2_k127_1312385_2	1121930.AQXG01000015_gene1830	4.521e-102	341.0	COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,1IYE3@117747|Sphingobacteriia	976|Bacteroidetes	P	Sodium/calcium exchanger protein	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS2_k127_1312385_0	1009370.ALO_00935	0.0	1927.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_1312385_1	1122921.KB898201_gene3226	1.646e-229	747.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	bacC	-	-	ko:K16122	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
CMS2_k127_131983_2	317936.Nos7107_2811	4.076e-48	193.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1HMDR@1161|Nostocales	1117|Cyanobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_4,TPR_7
CMS2_k127_131983_0	497965.Cyan7822_3560	2.125e-96	355.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,3KGI4@43988|Cyanothece	1117|Cyanobacteria	N	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_8
CMS2_k127_131983_1	1499967.BAYZ01000115_gene2931	3.161e-58	232.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_16,TPR_7,TPR_8
CMS2_k127_131983_4	1158338.JNLJ01000001_gene953	6.982e-21	109.0	COG0666@1|root,COG0666@2|Bacteria,2G4WB@200783|Aquificae	200783|Aquificae	S	Ankyrin repeats (3 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_4,Ank_5
CMS2_k127_131983_3	317936.Nos7107_0368	6.011e-26	115.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1HK1F@1161|Nostocales	1117|Cyanobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_7,TPR_8
CMS2_k127_131983_7	288000.BBta_5464	0.0005955	49.0	COG4249@1|root,COG4249@2|Bacteria,1R3WZ@1224|Proteobacteria,2TUBK@28211|Alphaproteobacteria,3JS5H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Caspase domain	MA20_02090	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
CMS2_k127_131983_6	767817.Desgi_1053	2.48e-09	62.0	COG3668@1|root,COG3668@2|Bacteria,1VHZU@1239|Firmicutes,2549A@186801|Clostridia	186801|Clostridia	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
CMS2_k127_1330279_0	479437.Elen_2089	7.988e-97	330.0	COG2414@1|root,COG2414@2|Bacteria,2IF1J@201174|Actinobacteria,4CV7Z@84998|Coriobacteriia	84998|Coriobacteriia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS2_k127_1330279_1	1499967.BAYZ01000081_gene1054	2.003e-15	84.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	ATC_hydrolase,SWIM
CMS2_k127_1331901_2	1229487.AMYW01000009_gene1226	8.739e-154	494.0	COG1834@1|root,COG1834@2|Bacteria	2|Bacteria	E	dimethylargininase activity	-	-	2.1.4.1	ko:K00613	ko00260,ko00330,ko01100,map00260,map00330,map01100	M00047	R00565,R01989	RC00024,RC02749	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidinotransf
CMS2_k127_1331901_6	765911.Thivi_1543	1.322e-24	105.0	COG2026@1|root,COG2026@2|Bacteria,1N80B@1224|Proteobacteria,1SDK6@1236|Gammaproteobacteria,1WZ7U@135613|Chromatiales	135613|Chromatiales	DJ	PFAM plasmid	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
CMS2_k127_1331901_0	767817.Desgi_2880	0.0	1520.0	COG1201@1|root,COG1201@2|Bacteria,1UHYQ@1239|Firmicutes,25E79@186801|Clostridia,263PU@186807|Peptococcaceae	186801|Clostridia	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
CMS2_k127_1331901_5	449447.MAE_49740	1.698e-48	179.0	COG1848@1|root,COG1848@2|Bacteria,1G8T6@1117|Cyanobacteria	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_1331901_3	661367.LLO_0643	2.406e-98	325.0	COG3410@1|root,COG3410@2|Bacteria,1PRQ3@1224|Proteobacteria,1RR13@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized conserved protein (DUF2075)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2075
CMS2_k127_1331901_1	661367.LLO_0643	1.358e-199	629.0	COG3410@1|root,COG3410@2|Bacteria,1PRQ3@1224|Proteobacteria,1RR13@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized conserved protein (DUF2075)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2075
CMS2_k127_1331901_4	760192.Halhy_2580	3.819e-88	298.0	COG5464@1|root,COG5464@2|Bacteria,4NGSI@976|Bacteroidetes	976|Bacteroidetes	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_1337001_7	1499967.BAYZ01000159_gene543	6.869e-92	314.0	COG1489@1|root,COG1489@2|Bacteria,2NRRA@2323|unclassified Bacteria	2|Bacteria	S	Sugar fermentation stimulation protein	sfsA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005975,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0044238,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
CMS2_k127_1337001_0	945713.IALB_0283	0.0	1326.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
CMS2_k127_1337001_22	933262.AXAM01000003_gene2826	3.046e-05	57.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_1337001_3	1121904.ARBP01000015_gene217	6.269e-166	536.0	COG2939@1|root,COG2939@2|Bacteria,4NF48@976|Bacteroidetes,47KU0@768503|Cytophagia	976|Bacteroidetes	E	Serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
CMS2_k127_1337001_11	526222.Desal_3256	7.952e-47	177.0	COG0518@1|root,COG0518@2|Bacteria	2|Bacteria	F	GMP synthase (glutamine-hydrolyzing) activity	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
CMS2_k127_1337001_19	1230342.CTM_00890	2.261e-08	63.0	COG0741@1|root,COG0741@2|Bacteria,1V6K4@1239|Firmicutes,24JB5@186801|Clostridia,36J2Z@31979|Clostridiaceae	186801|Clostridia	M	transglycosylase	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
CMS2_k127_1337001_4	1047013.AQSP01000142_gene126	3.614e-161	521.0	COG2070@1|root,COG2070@2|Bacteria,2NNYB@2323|unclassified Bacteria	2|Bacteria	S	Nitronate monooxygenase	npd	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
CMS2_k127_1337001_21	1286632.P278_07250	9.362e-06	57.0	COG3391@1|root,COG3391@2|Bacteria,4PAMR@976|Bacteroidetes,1IBW9@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128
CMS2_k127_1337001_10	502025.Hoch_3876	9.796e-56	212.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42NY2@68525|delta/epsilon subdivisions,2WJKQ@28221|Deltaproteobacteria,2YXDF@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF1566,Pkinase
CMS2_k127_1337001_9	391625.PPSIR1_15745	2.333e-86	308.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,4345S@68525|delta/epsilon subdivisions,2X1UG@28221|Deltaproteobacteria,2YTU5@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
CMS2_k127_1337001_18	523791.Kkor_2364	3.004e-18	100.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1RENP@1224|Proteobacteria,1S4IW@1236|Gammaproteobacteria,1XJ8G@135619|Oceanospirillales	135619|Oceanospirillales	M	Belongs to the ompA family	oprF	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA,TSP_3
CMS2_k127_1337001_6	879212.DespoDRAFT_03506	4.733e-104	350.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N38@68525|delta/epsilon subdivisions,2WK56@28221|Deltaproteobacteria,2MHP9@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Di-haem cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,Cytochrom_C
CMS2_k127_1337001_12	697303.Thewi_0895	8.586e-43	165.0	COG1600@1|root,COG1600@2|Bacteria,1TP6Q@1239|Firmicutes,24B04@186801|Clostridia,42FY0@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_16,Fer4_7
CMS2_k127_1337001_20	273075.Ta1322	1.816e-06	61.0	COG3391@1|root,arCOG02560@2157|Archaea,2Y65W@28890|Euryarchaeota,242AM@183967|Thermoplasmata	183967|Thermoplasmata	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1337001_5	649639.Bcell_1278	8.987e-137	448.0	COG0624@1|root,COG0624@2|Bacteria,1TQS9@1239|Firmicutes,4HDHW@91061|Bacilli,1ZBDC@1386|Bacillus	91061|Bacilli	E	Acetylornithine deacetylase	yodQ	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS2_k127_1337001_8	395492.Rleg2_4946	9.074e-92	317.0	COG2843@1|root,COG2843@2|Bacteria,1N79C@1224|Proteobacteria,2UMW8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
CMS2_k127_1337001_14	880073.Calab_0774	7.383e-32	126.0	COG0234@1|root,COG0234@2|Bacteria,2NPW2@2323|unclassified Bacteria	2|Bacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
CMS2_k127_1337001_1	1047013.AQSP01000132_gene1730	3.006e-243	761.0	COG0459@1|root,COG0459@2|Bacteria,2NNM6@2323|unclassified Bacteria	2|Bacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS2_k127_1337001_2	1191523.MROS_2226	5.188e-240	759.0	COG1297@1|root,COG1297@2|Bacteria	2|Bacteria	S	iron-nicotianamine transmembrane transporter activity	oliA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085	-	-	-	-	-	-	-	-	-	-	OPT
CMS2_k127_1337001_13	517418.Ctha_2172	1.682e-36	151.0	COG1463@1|root,COG1463@2|Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component	ycf22	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
CMS2_k127_1337001_16	517418.Ctha_2171	1.379e-20	98.0	COG1127@1|root,COG1127@2|Bacteria	2|Bacteria	Q	ATPase activity	ttg2A	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
CMS2_k127_1345456_0	1122621.ATZA01000001_gene1898	5.615e-135	444.0	COG2865@1|root,COG2865@2|Bacteria,4NGFJ@976|Bacteroidetes,1IQMG@117747|Sphingobacteriia	976|Bacteroidetes	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_24,HTH_DeoR
CMS2_k127_1345456_1	1469607.KK073768_gene2026	2.844e-37	156.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G2QK@1117|Cyanobacteria,1HM44@1161|Nostocales	1117|Cyanobacteria	LO	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,CHAT,TPR_12,TPR_8
CMS2_k127_1350538_1	1174528.JH992893_gene6031	9.213e-145	480.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_1350538_0	1196323.ALKF01000205_gene4118	1.952e-165	543.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes	1239|Firmicutes	Q	synthase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_13988_0	1337936.IJ00_21410	4.309e-56	222.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1HK1F@1161|Nostocales	1117|Cyanobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
CMS2_k127_13988_1	1122221.JHVI01000001_gene1761	7.712e-10	71.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	GUN4,Peptidase_C14
CMS2_k127_14319_0	755731.Clo1100_2633	9.849e-192	623.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1460621_0	471854.Dfer_1607	2.275e-214	715.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47TR0@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Response_reg,Y_Y_Y
CMS2_k127_146473_35	1341151.ASZU01000008_gene1395	9.321e-58	214.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,27B9F@186824|Thermoactinomycetaceae	91061|Bacilli	KLT	Serine/Threonine protein kinases, catalytic domain	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_146473_36	1209072.ALBT01000032_gene2033	1.235e-56	222.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1FIIU@10|Cellvibrio	1236|Gammaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,Pkinase,RyR,TPR_10,TPR_12
CMS2_k127_146473_57	237368.SCABRO_03544	9.772e-30	137.0	COG0515@1|root,COG0666@1|root,COG0790@1|root,COG0515@2|Bacteria,COG0666@2|Bacteria,COG0790@2|Bacteria,2J1KC@203682|Planctomycetes	2|Bacteria	KLT	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4,Sel1,TPR_16,TPR_19,TonB_C
CMS2_k127_146473_8	880073.Calab_0793	6.172e-151	481.0	COG1951@1|root,COG1951@2|Bacteria,2NNWE@2323|unclassified Bacteria	2|Bacteria	C	Fumarate hydratase (Fumerase)	fumA	-	4.2.1.2	ko:K01676,ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
CMS2_k127_146473_39	324925.Ppha_1569	1.295e-52	191.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1FEPI@1090|Chlorobi	1090|Chlorobi	C	Catalyzes the reversible hydration of fumarate to (S)- malate	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
CMS2_k127_146473_4	929562.Emtol_2946	1.625e-191	614.0	COG0154@1|root,COG0154@2|Bacteria,4NF8C@976|Bacteroidetes,47KZQ@768503|Cytophagia	976|Bacteroidetes	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS2_k127_146473_53	1519464.HY22_02245	1.597e-33	134.0	COG4914@1|root,COG4914@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204
CMS2_k127_146473_58	1178825.ALIH01000003_gene2206	2.9e-27	121.0	COG0400@1|root,COG0400@2|Bacteria	2|Bacteria	S	palmitoyl-(protein) hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Asp2
CMS2_k127_146473_48	429009.Adeg_0700	2.618e-35	145.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CMS2_k127_146473_23	1047013.AQSP01000134_gene1332	2.174e-84	299.0	COG1538@1|root,COG1538@2|Bacteria,2NP5D@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
CMS2_k127_146473_69	177437.HRM2_11630	1.469e-05	56.0	28RRT@1|root,33K0J@2|Bacteria,1NKEP@1224|Proteobacteria,430T6@68525|delta/epsilon subdivisions,2WW1A@28221|Deltaproteobacteria,2MNQS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3187)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3187
CMS2_k127_146473_3	1499967.BAYZ01000141_gene6153	1.102e-205	672.0	COG1262@1|root,COG1262@2|Bacteria,2NR84@2323|unclassified Bacteria	2|Bacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,Peptidase_C14,Pkinase
CMS2_k127_146473_19	1499967.BAYZ01000141_gene6151	2.259e-94	321.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
CMS2_k127_146473_46	1499967.BAYZ01000141_gene6149	2.427e-39	163.0	COG2944@1|root,COG2944@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,GUN4,HTH_3,TIR_2
CMS2_k127_146473_50	1869.MB27_36265	2.158e-34	148.0	COG1413@1|root,COG5635@1|root,COG1413@2|Bacteria,COG5635@2|Bacteria,2GNCH@201174|Actinobacteria,4D8ZG@85008|Micromonosporales	201174|Actinobacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4062,HEAT_2,NACHT
CMS2_k127_146473_12	273068.TTE1010	1.484e-138	463.0	COG1164@1|root,COG1164@2|Bacteria,1TP4P@1239|Firmicutes,248TP@186801|Clostridia,42EXS@68295|Thermoanaerobacterales	186801|Clostridia	E	M3B, thimet oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
CMS2_k127_146473_61	221288.JH992901_gene3360	1.269e-15	83.0	COG0824@1|root,COG0824@2|Bacteria,1G6JT@1117|Cyanobacteria,1JKVR@1189|Stigonemataceae	1117|Cyanobacteria	S	Acyl-ACP thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-ACP_TE
CMS2_k127_146473_40	1123371.ATXH01000001_gene1313	7.997e-52	188.0	COG0233@1|root,COG0233@2|Bacteria,2GHEC@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
CMS2_k127_146473_26	290397.Adeh_0280	1.894e-80	274.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,2YU4R@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
CMS2_k127_146473_30	484019.THA_991	1.475e-71	246.0	COG0264@1|root,COG0264@2|Bacteria,2GCGY@200918|Thermotogae	200918|Thermotogae	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
CMS2_k127_146473_25	1047013.AQSP01000139_gene2404	2.971e-82	282.0	COG0052@1|root,COG0052@2|Bacteria,2NP4M@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
CMS2_k127_146473_42	1047013.AQSP01000139_gene2403	2.203e-47	173.0	COG0103@1|root,COG0103@2|Bacteria,2NPN8@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
CMS2_k127_146473_38	585394.RHOM_01470	9.515e-53	189.0	COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia	186801|Clostridia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
CMS2_k127_146473_9	945713.IALB_0896	2.258e-150	491.0	COG0606@1|root,COG0606@2|Bacteria	2|Bacteria	O	chelatase, subunit chli	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
CMS2_k127_146473_29	880073.Calab_3649	6.809e-75	269.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2NP1D@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase SLT domain	CP_0155	-	-	ko:K08307,ko:K12204	-	-	-	-	ko00000,ko01000,ko01011,ko02044	3.A.7.10.1,3.A.7.9.1	-	-	LysM,SLT,T4SS_TraI
CMS2_k127_146473_33	639282.DEFDS_0024	1.305e-62	237.0	COG1100@1|root,COG1100@2|Bacteria,2GEYH@200930|Deferribacteres	200930|Deferribacteres	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
CMS2_k127_146473_34	381764.Fnod_1034	3.348e-58	219.0	COG1032@1|root,COG1032@2|Bacteria,2GCFE@200918|Thermotogae	200918|Thermotogae	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_146473_7	502025.Hoch_4734	4.503e-166	546.0	COG1164@1|root,COG1164@2|Bacteria,1Q3C4@1224|Proteobacteria,4393F@68525|delta/epsilon subdivisions,2X49B@28221|Deltaproteobacteria,2YYJ7@29|Myxococcales	28221|Deltaproteobacteria	E	Oligoendopeptidase f	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_146473_67	1236517.BAKO01000004_gene857	6.237e-07	60.0	COG0560@1|root,COG0560@2|Bacteria,4NIAJ@976|Bacteroidetes,2FQT9@200643|Bacteroidia	976|Bacteroidetes	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
CMS2_k127_146473_20	1121035.AUCH01000012_gene3047	3.164e-93	311.0	COG1573@1|root,COG1573@2|Bacteria,1PIX8@1224|Proteobacteria,2VKZ8@28216|Betaproteobacteria,2KU6J@206389|Rhodocyclales	206389|Rhodocyclales	L	PFAM Uracil-DNA glycosylase superfamily	smuG	-	-	ko:K10800	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
CMS2_k127_146473_2	1499967.BAYZ01000188_gene3892	2.869e-254	790.0	COG0031@1|root,COG0031@2|Bacteria,2NNZI@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47,6.2.1.30	ko:K01738,ko:K01912	ko00270,ko00360,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko05111,map00270,map00360,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map05111	M00021	R00897,R02539,R03601,R04859	RC00004,RC00014,RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_146473_43	926560.KE387023_gene2038	7.449e-45	171.0	COG1802@1|root,COG1802@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS2_k127_146473_63	1497679.EP56_11470	8.429e-12	70.0	2AEMC@1|root,314H9@2|Bacteria,1W0UA@1239|Firmicutes,4HRRY@91061|Bacilli	91061|Bacilli	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
CMS2_k127_146473_64	1499967.BAYZ01000075_gene2072	3.293e-09	70.0	COG2165@1|root,COG2165@2|Bacteria,2NQ2Y@2323|unclassified Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	pulG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
CMS2_k127_146473_10	313628.LNTAR_21300	5.487e-148	481.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_146473_13	1123376.AUIU01000012_gene1330	1.57e-129	436.0	COG0370@1|root,COG0370@2|Bacteria	2|Bacteria	P	ferrous iron transmembrane transporter activity	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
CMS2_k127_146473_68	573064.Mefer_0768	9.622e-07	53.0	COG1918@1|root,arCOG02102@2157|Archaea,2Y1KQ@28890|Euryarchaeota,23RSK@183939|Methanococci	183939|Methanococci	P	PFAM FeoA family protein	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
CMS2_k127_146473_17	944480.ATUV01000002_gene281	3.386e-113	374.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,42P1T@68525|delta/epsilon subdivisions,2WKZB@28221|Deltaproteobacteria,2M6WN@213113|Desulfurellales	28221|Deltaproteobacteria	F	Phosphohydrolase-associated domain	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
CMS2_k127_146473_5	1047013.AQSP01000109_gene2432	1.183e-186	613.0	COG5009@1|root,COG5009@2|Bacteria,2NS4K@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase	mrcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
CMS2_k127_146473_28	880073.Calab_1106	2.388e-75	259.0	COG2080@1|root,COG2080@2|Bacteria,2NPPX@2323|unclassified Bacteria	2|Bacteria	C	PFAM 2Fe-2S -binding	-	-	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2,TAT_signal
CMS2_k127_146473_0	880073.Calab_1107	6.554e-312	974.0	COG1529@1|root,COG1529@2|Bacteria,2NPHP@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
CMS2_k127_146473_14	880073.Calab_1108	5.256e-125	408.0	COG1319@1|root,COG1319@2|Bacteria,2NQUQ@2323|unclassified Bacteria	2|Bacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
CMS2_k127_146473_55	1121448.DGI_2214	3.62e-30	135.0	COG0330@1|root,COG0330@2|Bacteria,1R93I@1224|Proteobacteria	1224|Proteobacteria	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS2_k127_146473_52	1121448.DGI_2214	1.021e-33	146.0	COG0330@1|root,COG0330@2|Bacteria,1R93I@1224|Proteobacteria	1224|Proteobacteria	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS2_k127_146473_22	1047013.AQSP01000132_gene1709	1.254e-88	305.0	COG2071@1|root,COG2071@2|Bacteria,2NPQK@2323|unclassified Bacteria	2|Bacteria	S	Peptidase C26	puuD	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
CMS2_k127_146473_15	1047013.AQSP01000099_gene1503	7.254e-116	395.0	COG0323@1|root,COG0323@2|Bacteria,2NNP7@2323|unclassified Bacteria	2|Bacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	2.1.1.37	ko:K00558,ko:K03572	ko00270,ko01100,ko03430,ko05206,map00270,map01100,map03430,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036,ko03400	-	-	-	DNA_mis_repair,HATPase_c,HATPase_c_3,MutL_C
CMS2_k127_146473_18	667014.Thein_1806	6.301e-97	332.0	COG2204@1|root,COG2204@2|Bacteria,2GHIR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_146473_66	1207063.P24_18117	1.793e-07	59.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2JPCQ@204441|Rhodospirillales	204441|Rhodospirillales	P	COG2217 Cation transport ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
CMS2_k127_146473_59	1541960.KQ78_00249	2.697e-21	103.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_146473_70	247634.GPB2148_333	1.828e-05	56.0	COG2067@1|root,COG2067@2|Bacteria,1RFDS@1224|Proteobacteria,1SBRG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Protein of unknown function (DUF3187)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3187
CMS2_k127_146473_24	1047013.AQSP01000109_gene2431	4.32e-84	306.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_146473_49	1047013.AQSP01000111_gene1689	5.885e-35	141.0	COG1595@1|root,COG1595@2|Bacteria,2NPR9@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_146473_31	1047013.AQSP01000098_gene2564	2.973e-70	248.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4241,HEAT,HEAT_2
CMS2_k127_146473_41	643473.KB235930_gene4071	1.396e-48	186.0	COG5464@1|root,COG5464@2|Bacteria,1G2UF@1117|Cyanobacteria,1HKPY@1161|Nostocales	1117|Cyanobacteria	S	transposase or invertase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_146473_21	234267.Acid_3064	3.944e-90	337.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cu-oxidase_3,HYR,PAP2,PATR,P_proprotein,Peptidase_M14,Peptidase_M64,Peptidase_S8,SLH
CMS2_k127_146473_27	1232437.KL661978_gene3875	1.011e-76	263.0	COG1305@1|root,COG1305@2|Bacteria,1R9XR@1224|Proteobacteria,42QTZ@68525|delta/epsilon subdivisions,2WMV1@28221|Deltaproteobacteria,2MJRM@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
CMS2_k127_146473_6	945713.IALB_2970	1.398e-176	575.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	PD40,Peptidase_S9
CMS2_k127_146473_37	1211814.CAPG01000032_gene1504	3.208e-55	200.0	COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,4H9TC@91061|Bacilli,1ZRBC@1386|Bacillus	91061|Bacilli	KO	COG0378 Ni2 -binding GTPase involved in regulation of expression and maturation of urease and hydrogenase	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
CMS2_k127_146473_44	1192034.CAP_2345	8.884e-44	171.0	2E0M7@1|root,32W6F@2|Bacteria,1NB9Z@1224|Proteobacteria,42W6T@68525|delta/epsilon subdivisions,2WSFF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_146473_11	1047013.AQSP01000043_gene54	2.085e-145	467.0	COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
CMS2_k127_146473_72	391623.TERMP_00525	0.0001416	53.0	COG1266@1|root,arCOG05750@2157|Archaea,2XTC5@28890|Euryarchaeota,24431@183968|Thermococci	183968|Thermococci	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
CMS2_k127_146473_16	926550.CLDAP_22570	2.062e-114	381.0	COG1158@1|root,COG1158@2|Bacteria,2G5UQ@200795|Chloroflexi	200795|Chloroflexi	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_RNA_bind
CMS2_k127_146473_1	1121930.AQXG01000018_gene756	1.471e-255	820.0	COG1506@1|root,COG1506@2|Bacteria,4NDVD@976|Bacteroidetes,1IR4H@117747|Sphingobacteriia	976|Bacteroidetes	E	peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
CMS2_k127_146473_65	511051.CSE_13130	7.931e-08	62.0	COG2804@1|root,COG2804@2|Bacteria	2|Bacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
CMS2_k127_146473_32	344747.PM8797T_29158	5.085e-66	237.0	COG0265@1|root,COG0265@2|Bacteria,2IYNW@203682|Planctomycetes	203682|Planctomycetes	O	C-terminal PDZ domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Trypsin_2
CMS2_k127_146473_71	794903.OPIT5_27760	5.003e-05	56.0	2BQU3@1|root,32JQV@2|Bacteria,46YR1@74201|Verrucomicrobia,3KA17@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_146473_56	344747.PM8797T_20084	8.939e-30	138.0	COG3391@1|root,COG3391@2|Bacteria,2IY8U@203682|Planctomycetes	203682|Planctomycetes	M	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS2_k127_146473_47	332101.JIBU02000028_gene2699	7.199e-38	157.0	COG0436@1|root,COG0436@2|Bacteria,1TQP0@1239|Firmicutes,2488K@186801|Clostridia,36FI4@31979|Clostridiaceae	186801|Clostridia	E	PFAM aminotransferase, class I	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_146473_45	1047013.AQSP01000106_gene1773	4.213e-40	165.0	COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4976,Sulfatase
CMS2_k127_146473_51	335543.Sfum_0219	4.16e-34	147.0	COG0457@1|root,COG3118@1|root,COG3379@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,COG3379@2|Bacteria,1NBJ6@1224|Proteobacteria,42XTF@68525|delta/epsilon subdivisions,2WSZG@28221|Deltaproteobacteria,2MRX9@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
CMS2_k127_1480798_3	1047013.AQSP01000123_gene1546	5.46e-08	55.0	COG4953@1|root,COG4953@2|Bacteria,2NQMA@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-Binding Protein C-terminus Family	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
CMS2_k127_1480798_2	525919.Apre_1435	1.041e-26	117.0	COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24C0U@186801|Clostridia,22JFN@1570339|Peptoniphilaceae	186801|Clostridia	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS2_k127_1480798_1	1168034.FH5T_13945	3.221e-60	223.0	COG1680@1|root,COG1680@2|Bacteria,4NHA7@976|Bacteroidetes	976|Bacteroidetes	V	Beta-lactamase class C and other penicillin binding	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
CMS2_k127_1480798_4	457396.CSBG_02715	5.12e-07	58.0	COG0454@1|root,COG0454@2|Bacteria,1V3SX@1239|Firmicutes,24G4B@186801|Clostridia,36I67@31979|Clostridiaceae	186801|Clostridia	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_1480798_0	1379270.AUXF01000002_gene1544	7.528e-73	253.0	COG3653@1|root,COG3653@2|Bacteria	2|Bacteria	Q	N-Acyl-D-aspartate D-glutamate deacylase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
CMS2_k127_1525652_0	1035193.HMPREF9073_01033	3.017e-51	194.0	COG3209@1|root,COG3209@2|Bacteria,4NGJF@976|Bacteroidetes,1HYT1@117743|Flavobacteriia,1EQF7@1016|Capnocytophaga	976|Bacteroidetes	M	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TNT,VCBS
CMS2_k127_1525652_1	1035193.HMPREF9073_01032	2.994e-10	67.0	2EM9R@1|root,33EYU@2|Bacteria,4NXVR@976|Bacteroidetes,1IC8C@117743|Flavobacteriia,1ESTM@1016|Capnocytophaga	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1525652_2	1035193.HMPREF9073_01032	0.0006157	48.0	2EM9R@1|root,33EYU@2|Bacteria,4NXVR@976|Bacteroidetes,1IC8C@117743|Flavobacteriia,1ESTM@1016|Capnocytophaga	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1558062_7	593750.Metfor_0341	7.303e-28	117.0	arCOG03732@1|root,arCOG07676@1|root,arCOG09612@1|root,arCOG03732@2157|Archaea,arCOG07676@2157|Archaea,arCOG09612@2157|Archaea,2Y4EU@28890|Euryarchaeota	28890|Euryarchaeota	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
CMS2_k127_1558062_8	552811.Dehly_0169	2.741e-18	86.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	ko:K07339	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HicA_toxin
CMS2_k127_1558062_9	269797.Mbar_A2122	2.937e-18	87.0	COG1598@1|root,arCOG02411@2157|Archaea,2Y05G@28890|Euryarchaeota,2NA4X@224756|Methanomicrobia	224756|Methanomicrobia	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
CMS2_k127_1558062_0	1499967.BAYZ01000153_gene1544	4.078e-215	679.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35
CMS2_k127_1558062_1	760192.Halhy_4671	3.266e-60	236.0	COG1262@1|root,COG4249@1|root,COG1262@2|Bacteria,COG4249@2|Bacteria,4NEUZ@976|Bacteroidetes,1IYJ6@117747|Sphingobacteriia	976|Bacteroidetes	S	Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14,Trypsin_2
CMS2_k127_1558062_4	1379698.RBG1_1C00001G1616	5.289e-37	162.0	COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria	2|Bacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_8
CMS2_k127_1558062_5	68170.KL590519_gene8185	3.906e-29	136.0	COG5635@1|root,COG5635@2|Bacteria,2GNCH@201174|Actinobacteria,4E9M5@85010|Pseudonocardiales	201174|Actinobacteria	T	Domain of unknown function (DUF4062)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4062,NACHT
CMS2_k127_1558062_10	545694.TREPR_0316	9.189e-16	80.0	COG1708@1|root,COG1708@2|Bacteria,2JB6D@203691|Spirochaetes	203691|Spirochaetes	L	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1558062_6	443144.GM21_2610	6.174e-28	118.0	2E4AB@1|root,32Z61@2|Bacteria,1N9UX@1224|Proteobacteria,42UQD@68525|delta/epsilon subdivisions	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1558062_2	1196029.ALIM01000023_gene232	1.07e-56	208.0	COG1506@1|root,COG1506@2|Bacteria,1U5SB@1239|Firmicutes,4HB1A@91061|Bacilli,1ZCSB@1386|Bacillus	91061|Bacilli	E	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
CMS2_k127_1558062_3	177437.HRM2_15040	6.9e-45	180.0	COG0745@1|root,COG4191@1|root,COG5002@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MI2B@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_8,PAS_9,Response_reg
CMS2_k127_1563705_3	1313421.JHBV01000015_gene5729	3.403e-26	126.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,Gram_pos_anchor
CMS2_k127_1563705_1	1183438.GKIL_1369	4.293e-118	413.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
CMS2_k127_1563705_4	204536.SULAZ_0155	8.746e-07	52.0	COG1672@1|root,COG1672@2|Bacteria,2G4U4@200783|Aquificae	200783|Aquificae	S	Conserved protein, with A weak D-galactarate dehydratase altronate hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,PDDEXK_9
CMS2_k127_1563705_0	880073.Calab_0030	4.072e-275	865.0	COG1501@1|root,COG3250@1|root,COG1501@2|Bacteria,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	AXE1,He_PIG,He_PIG_assoc,Melibiase_2,NPCBM
CMS2_k127_1563705_2	1278073.MYSTI_01781	2.273e-94	338.0	COG2312@1|root,COG2312@2|Bacteria,1NEZB@1224|Proteobacteria,433VP@68525|delta/epsilon subdivisions,2X3PC@28221|Deltaproteobacteria,2YWR8@29|Myxococcales	28221|Deltaproteobacteria	S	Erythromycin esterase	-	-	-	ko:K06880	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	CarboxypepD_reg,Erythro_esteras
CMS2_k127_1563705_5	1027292.HMPREF9372_3102	9.574e-06	59.0	COG2207@1|root,COG2207@2|Bacteria,1TQKE@1239|Firmicutes,4HAA2@91061|Bacilli,26EGH@186818|Planococcaceae	91061|Bacilli	K	helix_turn_helix, arabinose operon control protein	-	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019243,GO:0019249,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046185,GO:0046394,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:1901575,GO:1901576,GO:1901615,GO:1901617	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18
CMS2_k127_1604211_0	649747.HMPREF0083_00279	4.991e-298	960.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16123,ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1604211_1	509191.AEDB02000067_gene916	1.576e-197	629.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_1604452_1	671143.DAMO_0826	2.748e-66	236.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	ko:K02569,ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT,Cytochrome_C7
CMS2_k127_1604452_2	1047013.AQSP01000078_gene2048	1.08e-26	124.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,TonB_C
CMS2_k127_1604452_3	234267.Acid_1032	2.447e-10	72.0	COG0810@1|root,COG4219@1|root,COG0810@2|Bacteria,COG4219@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,Peptidase_M56,TonB_C
CMS2_k127_1604452_0	13035.Dacsa_2858	9.384e-91	315.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1G1Q1@1117|Cyanobacteria	1117|Cyanobacteria	EU	PFAM Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS2_k127_1655604_4	1121097.JCM15093_2530	2.575e-48	179.0	COG0664@1|root,COG0664@2|Bacteria,4NPF0@976|Bacteroidetes,2G2ZV@200643|Bacteroidia,4AW7D@815|Bacteroidaceae	976|Bacteroidetes	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
CMS2_k127_1655604_5	639282.DEFDS_1680	2.659e-33	130.0	2CG49@1|root,32Y3Y@2|Bacteria,2GG2B@200930|Deferribacteres	200930|Deferribacteres	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1655604_2	1347392.CCEZ01000008_gene2143	1.531e-133	433.0	COG1136@1|root,COG1136@2|Bacteria,1TPRH@1239|Firmicutes,24B0U@186801|Clostridia,36FCQ@31979|Clostridiaceae	186801|Clostridia	V	PFAM ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS2_k127_1655604_3	1321779.HMPREF1984_01612	4.327e-126	406.0	COG0378@1|root,COG0378@2|Bacteria,379PF@32066|Fusobacteria	32066|Fusobacteria	KO	CobW P47K family protein	-	-	-	-	-	-	-	-	-	-	-	-	cobW
CMS2_k127_1655604_1	1347392.CCEZ01000008_gene2145	9.106e-160	514.0	COG1840@1|root,COG1840@2|Bacteria,1TYKR@1239|Firmicutes,249E2@186801|Clostridia,36G38@31979|Clostridiaceae	186801|Clostridia	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858,SBP_bac_6
CMS2_k127_1655604_0	1047013.AQSP01000040_gene996	1.531e-185	595.0	COG0556@1|root,COG0556@2|Bacteria,2NNPM@2323|unclassified Bacteria	2|Bacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03702,ko:K08999	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
CMS2_k127_170096_3	1499967.BAYZ01000027_gene1768	1.481e-31	125.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,2NR8B@2323|unclassified Bacteria	2|Bacteria	T	NACHT domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,NACHT,NPCBM,PEGA,Pkinase
CMS2_k127_170096_2	102129.Lepto7375DRAFT_7471	1.001e-65	242.0	COG0775@1|root,COG1262@1|root,COG5635@1|root,COG0775@2|Bacteria,COG1262@2|Bacteria,COG5635@2|Bacteria	2|Bacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,HEAT_2,HEAT_PBS,NACHT,PNP_UDP_1
CMS2_k127_170096_1	1121904.ARBP01000004_gene1059	1.102e-195	636.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47NTJ@768503|Cytophagia	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_170096_0	1169144.KB910971_gene2149	0.0	1044.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	ko:K16093,ko:K16095	ko01054,map01054	-	-	-	ko00000,ko00001	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
CMS2_k127_1720876_0	404380.Gbem_0781	2.587e-206	645.0	COG1979@1|root,COG1979@2|Bacteria,1QUBJ@1224|Proteobacteria,42MPI@68525|delta/epsilon subdivisions,2WJGY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Iron-containing alcohol dehydrogenase	bdhA	-	1.1.1.1	ko:K00001,ko:K08325	ko00010,ko00071,ko00350,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R02528,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC00739,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
CMS2_k127_1720876_2	340099.Teth39_1595	7.344e-56	199.0	COG0716@1|root,COG0716@2|Bacteria,1V079@1239|Firmicutes,249HY@186801|Clostridia,42J9Z@68295|Thermoanaerobacterales	186801|Clostridia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
CMS2_k127_1720876_1	390874.Tpet_1740	6.263e-61	214.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS2_k127_17441_55	1262449.CP6013_3710	1.661e-05	56.0	COG1672@1|root,COG1672@2|Bacteria,1TPQR@1239|Firmicutes,24AIK@186801|Clostridia,36FFJ@31979|Clostridiaceae	186801|Clostridia	S	PFAM Archaeal ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,AAA_35,PDDEXK_3
CMS2_k127_17441_56	240292.Ava_1624	5.363e-05	55.0	COG2319@1|root,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1HKI2@1161|Nostocales	1117|Cyanobacteria	T	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35,WD40
CMS2_k127_17441_45	215803.DB30_1496	2.794e-19	104.0	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1NIID@1224|Proteobacteria,42YIQ@68525|delta/epsilon subdivisions,2WUCK@28221|Deltaproteobacteria,2YTXX@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_17441_51	1183438.GKIL_3643	6.031e-13	81.0	COG0457@1|root,COG1672@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,1G353@1117|Cyanobacteria	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_17441_36	321332.CYB_2318	4.605e-33	137.0	COG1011@1|root,COG1011@2|Bacteria,1G51I@1117|Cyanobacteria,1H0H2@1129|Synechococcus	1117|Cyanobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
CMS2_k127_17441_42	177437.HRM2_30030	3.117e-26	119.0	2EKNX@1|root,33ECP@2|Bacteria,1NQHA@1224|Proteobacteria,42YEX@68525|delta/epsilon subdivisions,2WUPR@28221|Deltaproteobacteria,2MMYQ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_17441_38	1121405.dsmv_3362	3.988e-31	130.0	COG1633@1|root,COG1633@2|Bacteria,1MY6B@1224|Proteobacteria,42TCR@68525|delta/epsilon subdivisions,2WP9M@28221|Deltaproteobacteria,2MKDD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Ferritin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_17441_10	526222.Desal_2780	6.354e-115	376.0	COG0428@1|root,COG0428@2|Bacteria,1MWEZ@1224|Proteobacteria,42NT2@68525|delta/epsilon subdivisions,2WJM5@28221|Deltaproteobacteria,2M7VT@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Mediates zinc uptake. May also transport other divalent cations	zupT	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
CMS2_k127_17441_28	1168034.FH5T_03995	2.203e-40	154.0	2A42S@1|root,30SMP@2|Bacteria	2|Bacteria	S	Nickel-containing superoxide dismutase	-	-	1.15.1.1	ko:K00518	-	-	-	-	ko00000,ko01000	-	-	-	Sod_Ni
CMS2_k127_17441_57	1125699.HMPREF9194_01866	0.0001352	52.0	COG0457@1|root,COG0457@2|Bacteria,2J780@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
CMS2_k127_17441_32	1047013.AQSP01000128_gene425	1.252e-37	149.0	COG0237@1|root,COG0237@2|Bacteria,2NPMB@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
CMS2_k127_17441_12	604354.TSIB_2051	4.03e-110	368.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,243U2@183968|Thermococci	183968|Thermococci	E	Beta-eliminating lyase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_17441_13	644968.DFW101_1731	6.096e-98	329.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42SGT@68525|delta/epsilon subdivisions,2X649@28221|Deltaproteobacteria,2MH06@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
CMS2_k127_17441_25	316067.Geob_0431	6.724e-46	175.0	COG0500@1|root,COG2226@2|Bacteria,1RFBE@1224|Proteobacteria,42VEH@68525|delta/epsilon subdivisions,2WVST@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
CMS2_k127_17441_4	1121423.JONT01000012_gene422	3.134e-131	427.0	COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,2480D@186801|Clostridia,260DK@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CMS2_k127_17441_18	880073.Calab_2528	3.489e-59	220.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	ugcG	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
CMS2_k127_17441_24	641491.DND132_0326	5.939e-46	172.0	COG0810@1|root,COG0810@2|Bacteria,1MZQW@1224|Proteobacteria,43BTI@68525|delta/epsilon subdivisions,2X74F@28221|Deltaproteobacteria,2MCV3@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Chalcone isomerase-like	-	-	-	-	-	-	-	-	-	-	-	-	Chalcone_3
CMS2_k127_17441_29	1123508.JH636442_gene4213	3.213e-39	155.0	COG2755@1|root,COG4409@1|root,COG2755@2|Bacteria,COG4409@2|Bacteria,2IX8T@203682|Planctomycetes	203682|Planctomycetes	G	BNR repeat-like domain	-	-	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2
CMS2_k127_17441_54	880072.Desac_1567	5.354e-06	55.0	290YH@1|root,2ZNK8@2|Bacteria,1P7TZ@1224|Proteobacteria,433I3@68525|delta/epsilon subdivisions,2WXS0@28221|Deltaproteobacteria,2MSEA@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_17441_8	468059.AUHA01000002_gene1252	2.529e-125	414.0	COG0508@1|root,COG0508@2|Bacteria,4NF33@976|Bacteroidetes,1IP4Q@117747|Sphingobacteriia	976|Bacteroidetes	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CMS2_k127_17441_0	880073.Calab_3040	0.0	1081.0	COG0567@1|root,COG0567@2|Bacteria,2NQJV@2323|unclassified Bacteria	2|Bacteria	C	Dehydrogenase E1 component	sucA	GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
CMS2_k127_17441_6	1121865.OMW_00925	2.273e-127	413.0	COG1209@1|root,COG1209@2|Bacteria,1V301@1239|Firmicutes,4H9R0@91061|Bacilli,4B0GS@81852|Enterococcaceae	91061|Bacilli	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CMS2_k127_17441_3	1047013.AQSP01000110_gene79	7.795e-140	459.0	COG0733@1|root,COG0733@2|Bacteria,2NQIH@2323|unclassified Bacteria	2|Bacteria	S	Sodium:neurotransmitter symporter family	CP_0468	-	-	ko:K03308,ko:K03466	-	-	-	-	ko00000,ko03036	2.A.22.4,2.A.22.5,3.A.12	-	-	SNF
CMS2_k127_17441_49	880073.Calab_3349	3.432e-15	89.0	COG0457@1|root,COG0457@2|Bacteria	880073.Calab_3349|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_17441_34	555088.DealDRAFT_2995	8.582e-36	148.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia,42JXA@68298|Syntrophomonadaceae	186801|Clostridia	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CMS2_k127_17441_35	59538.XP_005979555.1	2.391e-35	139.0	COG0526@1|root,KOG0910@2759|Eukaryota	2759|Eukaryota	O	glycerol ether metabolic process	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS2_k127_17441_46	1121405.dsmv_2768	1.541e-18	100.0	COG1807@1|root,COG1807@2|Bacteria,1MY0U@1224|Proteobacteria,42QGD@68525|delta/epsilon subdivisions,2WM6Q@28221|Deltaproteobacteria,2MJRD@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS2_k127_17441_14	1047013.AQSP01000139_gene2412	8.205e-98	335.0	COG0591@1|root,COG0591@2|Bacteria,2NRJT@2323|unclassified Bacteria	2|Bacteria	E	Sodium:solute symporter family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_17441_19	509191.AEDB02000075_gene2832	3.042e-58	218.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS2_k127_17441_27	1128421.JAGA01000002_gene1359	1.089e-44	176.0	COG0520@1|root,COG0520@2|Bacteria,2NP4B@2323|unclassified Bacteria	2|Bacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS2_k127_17441_33	1168034.FH5T_19045	3.856e-36	141.0	COG1765@1|root,COG1765@2|Bacteria,4NNTY@976|Bacteroidetes,2FU46@200643|Bacteroidia	976|Bacteroidetes	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
CMS2_k127_17441_20	1158338.JNLJ01000005_gene1640	1.07e-57	207.0	COG0177@1|root,COG0177@2|Bacteria,2G3TX@200783|Aquificae	200783|Aquificae	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
CMS2_k127_17441_15	880073.Calab_0479	5.457e-88	306.0	COG1032@1|root,COG1032@2|Bacteria,2NQIM@2323|unclassified Bacteria	2|Bacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_17441_26	1031288.AXAA01000004_gene1879	1.555e-45	175.0	COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia,36EJF@31979|Clostridiaceae	186801|Clostridia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
CMS2_k127_17441_11	203119.Cthe_2593	4.504e-114	378.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,3WGA4@541000|Ruminococcaceae	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CMS2_k127_17441_40	360107.CHAB381_0223	1.218e-28	116.0	COG0254@1|root,COG0254@2|Bacteria,1PT0H@1224|Proteobacteria,42V2Z@68525|delta/epsilon subdivisions,2YQ19@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
CMS2_k127_17441_2	742727.HMPREF9447_02891	4.208e-146	483.0	COG1429@1|root,COG1429@2|Bacteria,4P0BG@976|Bacteroidetes,2FMJ7@200643|Bacteroidia,4AN00@815|Bacteroidaceae	976|Bacteroidetes	H	COG NOG08812 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,PDDEXK_9
CMS2_k127_17441_17	1047013.AQSP01000138_gene1044	1.486e-72	256.0	COG2870@1|root,COG2870@2|Bacteria,2NNUT@2323|unclassified Bacteria	2|Bacteria	M	pfkB family carbohydrate kinase	rfaE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
CMS2_k127_17441_30	1047013.AQSP01000138_gene1046	1.403e-38	160.0	COG3307@1|root,COG3307@2|Bacteria,2NQ25@2323|unclassified Bacteria	2|Bacteria	M	O-Antigen ligase	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	Wzy_C
CMS2_k127_17441_22	1047013.AQSP01000138_gene1047	4.996e-54	202.0	COG0859@1|root,COG0859@2|Bacteria,2NP5P@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase, family 9	-	-	-	ko:K02843,ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS2_k127_17441_48	525897.Dbac_3220	1.835e-16	80.0	COG2835@1|root,COG2835@2|Bacteria,1Q1BG@1224|Proteobacteria,42WTN@68525|delta/epsilon subdivisions,2WSI9@28221|Deltaproteobacteria,2MD2I@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the UPF0434 family	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
CMS2_k127_17441_1	1131462.DCF50_p701	1.235e-285	892.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia,2618K@186807|Peptococcaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim
CMS2_k127_17441_23	1209989.TepiRe1_1575	2.373e-49	187.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,42EM8@68295|Thermoanaerobacterales	186801|Clostridia	T	protein phosphatase 2C domain protein	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
CMS2_k127_17441_52	395963.Bind_2162	4.706e-11	74.0	COG0535@1|root,COG0535@2|Bacteria,1N6IN@1224|Proteobacteria,2UMXR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_17441_41	743722.Sph21_3334	1.429e-27	123.0	COG3358@1|root,COG3358@2|Bacteria,4NNWJ@976|Bacteroidetes,1ITID@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
CMS2_k127_17441_9	903818.KI912268_gene764	4.04e-124	405.0	COG0618@1|root,COG0618@2|Bacteria	2|Bacteria	S	phosphoesterase RecJ domain protein	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	-
CMS2_k127_17441_39	96561.Dole_0624	2.815e-30	125.0	2CGNA@1|root,3301B@2|Bacteria,1N74P@1224|Proteobacteria,42VID@68525|delta/epsilon subdivisions,2WRHN@28221|Deltaproteobacteria,2MKUB@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Yippee-Mis18
CMS2_k127_17441_21	330214.NIDE4180	2.255e-54	196.0	COG2353@1|root,COG2353@2|Bacteria	2|Bacteria	O	YceI-like domain	Cj0420	-	-	-	-	-	-	-	-	-	-	-	YceI
CMS2_k127_17441_47	1089439.KB902241_gene978	1.912e-18	100.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,45ZRW@72273|Thiotrichales	72273|Thiotrichales	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
CMS2_k127_17441_53	1379281.AVAG01000053_gene384	1.842e-06	59.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,2M8QA@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	elongation factor SelB, winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
CMS2_k127_17441_43	938288.HG326224_gene1328	3.732e-24	118.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia,267IJ@186813|unclassified Clostridiales	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
CMS2_k127_17441_37	868131.MSWAN_1692	9.472e-33	135.0	COG1451@1|root,arCOG02625@2157|Archaea,2Y0AZ@28890|Euryarchaeota,23P96@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
CMS2_k127_17441_7	1517682.HW49_03275	1.507e-126	410.0	COG0648@1|root,COG0648@2|Bacteria,4NJDP@976|Bacteroidetes,2FPM6@200643|Bacteroidia,22WPU@171551|Porphyromonadaceae	976|Bacteroidetes	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
CMS2_k127_17441_44	344747.PM8797T_15596	2.627e-21	95.0	2BZBR@1|root,32YH6@2|Bacteria,2J41E@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_17441_31	1123261.AXDW01000003_gene1911	2.589e-38	149.0	COG4731@1|root,COG4731@2|Bacteria,1N19Y@1224|Proteobacteria,1SBCW@1236|Gammaproteobacteria,1X71P@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
CMS2_k127_17441_16	1307761.L21SP2_0717	2.713e-76	262.0	COG2013@1|root,COG2013@2|Bacteria,2J7X8@203691|Spirochaetes	203691|Spirochaetes	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
CMS2_k127_17441_5	345341.KUTG_04234	1.041e-128	418.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
CMS2_k127_180024_0	63737.Npun_F2181	7.683e-240	780.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_1815351_0	326427.Cagg_1070	1.85e-25	121.0	COG1337@1|root,COG1337@2|Bacteria,2GBU8@200795|Chloroflexi,376SA@32061|Chloroflexia	32061|Chloroflexia	L	RAMP superfamily	-	-	-	-	-	-	-	-	-	-	-	-	RAMPs
CMS2_k127_1815351_2	326427.Cagg_1071	4.636e-18	96.0	COG1337@1|root,COG1337@2|Bacteria,2GBUN@200795|Chloroflexi,376TZ@32061|Chloroflexia	32061|Chloroflexia	L	RAMP superfamily	-	-	-	ko:K19134	-	-	-	-	ko00000,ko02048	-	-	-	RAMPs
CMS2_k127_1815351_3	880072.Desac_2798	1.48e-15	85.0	COG1337@1|root,COG1337@2|Bacteria,1QHDR@1224|Proteobacteria,43A5Z@68525|delta/epsilon subdivisions,2WYDJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	RAMP superfamily	-	-	-	ko:K19134	-	-	-	-	ko00000,ko02048	-	-	-	RAMPs
CMS2_k127_1815351_1	163908.KB235896_gene1139	6.013e-23	113.0	COG1353@1|root,COG1353@2|Bacteria,1G295@1117|Cyanobacteria,1HR5W@1161|Nostocales	1117|Cyanobacteria	S	crispr-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1840491_0	1408422.JHYF01000017_gene1871	0.0	3036.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1885117_3	720555.BATR1942_07350	6.501e-165	540.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	ko:K15662,ko:K15663	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_1885117_1	755731.Clo1100_0890	0.0	1941.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1885117_2	1195236.CTER_0312	0.0	1484.0	COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_1885117_0	755731.Clo1100_0890	0.0	2032.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_1915176_0	234267.Acid_2818	1.29e-33	136.0	2EPXQ@1|root,33HI8@2|Bacteria,3Y5ZD@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1931080_9	748449.Halha_1115	2.558e-55	205.0	COG5464@1|root,COG5464@2|Bacteria,1UGME@1239|Firmicutes,248B2@186801|Clostridia	186801|Clostridia	S	transposase, YhgA-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
CMS2_k127_1931080_8	748449.Halha_1115	8.784e-58	213.0	COG5464@1|root,COG5464@2|Bacteria,1UGME@1239|Firmicutes,248B2@186801|Clostridia	186801|Clostridia	S	transposase, YhgA-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
CMS2_k127_1931080_0	469616.FMAG_00401	3.73e-270	843.0	COG1217@1|root,COG1217@2|Bacteria,378B5@32066|Fusobacteria	32066|Fusobacteria	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
CMS2_k127_1931080_6	1121405.dsmv_2190	3.79e-148	487.0	COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,42N7S@68525|delta/epsilon subdivisions,2WMBC@28221|Deltaproteobacteria,2MIMN@213118|Desulfobacterales	28221|Deltaproteobacteria	U	PFAM Peptidoglycan-binding domain 1 protein	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
CMS2_k127_1931080_10	1122990.BAJH01000013_gene1724	1.374e-54	195.0	COG2453@1|root,COG2453@2|Bacteria	2|Bacteria	T	phosphatase	-	-	3.1.3.16,3.1.3.48	ko:K04459,ko:K14165	ko04010,map04010	-	-	-	ko00000,ko00001,ko01000,ko01009	-	-	-	DSPc
CMS2_k127_1931080_4	1380384.JADN01000006_gene2443	1.828e-174	562.0	COG3344@1|root,COG3344@2|Bacteria,4NSHG@976|Bacteroidetes	976|Bacteroidetes	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
CMS2_k127_1931080_12	1380384.JADN01000006_gene2442	1.028e-46	177.0	2EQ3U@1|root,33HQ6@2|Bacteria,4P84W@976|Bacteroidetes,1IAXD@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1931080_13	1499967.BAYZ01000136_gene51	1.267e-33	151.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG4916@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,COG4916@2|Bacteria,2NR2E@2323|unclassified Bacteria	2|Bacteria	T	AAA ATPase domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_16,Guanylate_cyc,TIR_2,TPR_12,TPR_7
CMS2_k127_1931080_1	269797.Mbar_A2306	8.675e-202	657.0	COG1100@1|root,arCOG06769@2157|Archaea	2157|Archaea	S	Ras of Complex, Roc, domain of DAPkinase	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	COR,LRR_4,LRR_8,Roc
CMS2_k127_1931080_20	272559.BF9343_0044	6.949e-06	57.0	COG3391@1|root,COG3391@2|Bacteria,4P2J2@976|Bacteroidetes,2FP5A@200643|Bacteroidia,4APY7@815|Bacteroidaceae	976|Bacteroidetes	S	6-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128
CMS2_k127_1931080_18	555779.Dthio_PD3489	1.49e-07	59.0	COG5464@1|root,COG5464@2|Bacteria,1R5BN@1224|Proteobacteria,42ZSZ@68525|delta/epsilon subdivisions,2WUVA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	transposase or invertase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1931080_21	1408321.JNJD01000006_gene1242	6.219e-05	47.0	COG0790@1|root,COG2815@1|root,COG0790@2|Bacteria,COG2815@2|Bacteria,1UQZF@1239|Firmicutes,254AV@186801|Clostridia,27QHG@186928|unclassified Lachnospiraceae	186801|Clostridia	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
CMS2_k127_1931080_14	1123278.KB893543_gene5478	3.136e-32	138.0	COG1409@1|root,COG1409@2|Bacteria,4NECQ@976|Bacteroidetes,47N3U@768503|Cytophagia	976|Bacteroidetes	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_1931080_15	1336235.JAEG01000001_gene2333	6.801e-19	99.0	2EABA@1|root,334FH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TIG
CMS2_k127_1931080_11	1123236.KB899382_gene2312	5.083e-50	205.0	COG2333@1|root,COG2333@2|Bacteria	2|Bacteria	N	competence protein COMEC	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	CW_binding_1,Lactamase_B
CMS2_k127_1931080_7	1121930.AQXG01000014_gene350	2.138e-147	509.0	COG1404@1|root,COG2356@1|root,COG3291@1|root,COG1404@2|Bacteria,COG2356@2|Bacteria,COG3291@2|Bacteria,4PI1X@976|Bacteroidetes,1IXYZ@117747|Sphingobacteriia	976|Bacteroidetes	L	Endonuclease I	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_1
CMS2_k127_1931080_17	1162668.LFE_0156	1.253e-16	95.0	COG0790@1|root,COG4249@1|root,COG0790@2|Bacteria,COG4249@2|Bacteria,3J0QX@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Peptidase_C14
CMS2_k127_1931080_16	398720.MED217_13099	3.216e-17	97.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,4NS5V@976|Bacteroidetes	976|Bacteroidetes	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,TPR_1,TPR_16,TPR_2,TPR_8
CMS2_k127_1931080_5	760192.Halhy_5505	6.933e-168	568.0	COG1075@1|root,COG4249@1|root,COG1075@2|Bacteria,COG4249@2|Bacteria,4P04T@976|Bacteroidetes	976|Bacteroidetes	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1931080_2	1125863.JAFN01000001_gene2044	4.855e-197	632.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
CMS2_k127_1931080_3	589865.DaAHT2_1111	4.312e-195	630.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
CMS2_k127_1931080_19	269799.Gmet_1739	1.856e-06	54.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42MY3@68525|delta/epsilon subdivisions,2WJEF@28221|Deltaproteobacteria,43TQX@69541|Desulfuromonadales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
CMS2_k127_1943359_0	243275.TDE_0596	6.381e-121	397.0	COG3943@1|root,COG3943@2|Bacteria,2J6P2@203691|Spirochaetes	203691|Spirochaetes	S	Virulence protein RhuM family	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_RhuM
CMS2_k127_1943359_1	1480694.DC28_02160	2.882e-22	101.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,Peptidase_C14
CMS2_k127_1943359_2	1480694.DC28_02160	8.31e-19	90.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,Peptidase_C14
CMS2_k127_19541_4	694427.Palpr_2226	5.087e-80	297.0	COG3656@1|root,COG3656@2|Bacteria,4NHDQ@976|Bacteroidetes,2FTSH@200643|Bacteroidia,22Y91@171551|Porphyromonadaceae	976|Bacteroidetes	S	Fibronectin type 3 domain	-	-	-	ko:K21571	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_19541_13	515635.Dtur_1285	1.181e-12	82.0	COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PPC,Peptidase_M8,Peptidase_S8,SLH
CMS2_k127_19541_3	439235.Dalk_0237	1.652e-92	335.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_19541_5	1304888.ATWF01000001_gene1975	6.457e-77	276.0	COG3608@1|root,COG3608@2|Bacteria,2GESD@200930|Deferribacteres	200930|Deferribacteres	S	Carboxypeptidase controlling helical cell shape catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M99
CMS2_k127_19541_10	706587.Desti_1450	1.459e-41	169.0	COG3034@1|root,COG4319@1|root,COG3034@2|Bacteria,COG4319@2|Bacteria,1N2B6@1224|Proteobacteria,42QS4@68525|delta/epsilon subdivisions,2WPZF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
CMS2_k127_19541_8	556263.FSEG_01384	1.659e-54	199.0	COG0689@1|root,COG0689@2|Bacteria,3794V@32066|Fusobacteria	32066|Fusobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ham1p_like,RNase_PH,RNase_PH_C
CMS2_k127_19541_9	1047013.AQSP01000135_gene1573	4.719e-47	181.0	COG1560@1|root,COG1560@2|Bacteria,2NPD7@2323|unclassified Bacteria	2|Bacteria	M	Lipid A biosynthesis	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
CMS2_k127_19541_11	768670.Calni_1053	3.553e-20	102.0	COG1663@1|root,COG1663@2|Bacteria,2GFB8@200930|Deferribacteres	200930|Deferribacteres	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
CMS2_k127_19541_7	861452.HMPREF9093_01419	5.867e-55	208.0	COG0220@1|root,COG1519@1|root,COG0220@2|Bacteria,COG1519@2|Bacteria,378F3@32066|Fusobacteria	32066|Fusobacteria	M	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527,ko:K03439	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko03016	-	GT30	-	Glycos_transf_N,Methyltransf_4
CMS2_k127_19541_12	1123371.ATXH01000050_gene2026	6.348e-20	97.0	COG5464@1|root,COG5464@2|Bacteria	2|Bacteria	S	double-stranded DNA endodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
CMS2_k127_19541_2	485917.Phep_0555	7.047e-104	351.0	COG4403@1|root,COG4403@2|Bacteria,4NJ29@976|Bacteroidetes,1IXQ4@117747|Sphingobacteriia	976|Bacteroidetes	V	Lanthionine synthetase C-like protein	-	-	-	ko:K20484	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001	-	-	-	LANC_like
CMS2_k127_19541_14	411461.DORFOR_01985	1.982e-09	64.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1UZ35@1239|Firmicutes,25BI3@186801|Clostridia	186801|Clostridia	K	COG2207 AraC-type DNA-binding domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
CMS2_k127_19541_1	1047013.AQSP01000139_gene2329	6.477e-196	636.0	COG2091@1|root,COG2091@2|Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_19541_0	755731.Clo1100_2633	0.0	1075.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_197547_2	1408422.JHYF01000017_gene1871	5.591e-237	762.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_197547_14	313595.P700755_001481	3.903e-28	131.0	COG4886@1|root,COG4886@2|Bacteria,4PM97@976|Bacteroidetes	976|Bacteroidetes	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
CMS2_k127_197547_13	1454007.JAUG01000004_gene2670	6.636e-31	127.0	COG0526@1|root,COG0526@2|Bacteria,4NEX3@976|Bacteroidetes,1INSA@117747|Sphingobacteriia	976|Bacteroidetes	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF4369
CMS2_k127_197547_9	1047013.AQSP01000131_gene1841	8.439e-92	335.0	COG1629@1|root,COG4773@1|root,COG4771@2|Bacteria,COG4773@2|Bacteria,2NP6Z@2323|unclassified Bacteria	2|Bacteria	P	COGs COG1629 Outer membrane receptor protein mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
CMS2_k127_197547_10	289376.THEYE_A1186	2.488e-77	265.0	COG2003@1|root,COG2003@2|Bacteria,3J12V@40117|Nitrospirae	40117|Nitrospirae	L	Belongs to the UPF0758 family	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
CMS2_k127_197547_15	1209072.ALBT01000058_gene916	7.562e-07	61.0	28IW1@1|root,2Z8UB@2|Bacteria,1N1QM@1224|Proteobacteria,1RR0J@1236|Gammaproteobacteria,1FHSP@10|Cellvibrio	1236|Gammaproteobacteria	S	F plasmid transfer operon, TraF, protein	traF	-	-	-	-	-	-	-	-	-	-	-	TraF_2
CMS2_k127_197547_4	204669.Acid345_1392	5.548e-203	646.0	COG2804@1|root,COG2804@2|Bacteria,3Y3GB@57723|Acidobacteria,2JHVF@204432|Acidobacteriia	2|Bacteria	NU	PFAM Type II secretion system protein E	pilB	-	-	ko:K02454,ko:K02504,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
CMS2_k127_197547_6	639282.DEFDS_1110	5.724e-148	477.0	COG2805@1|root,COG2805@2|Bacteria,2GEWK@200930|Deferribacteres	200930|Deferribacteres	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS2_k127_197547_8	1047013.AQSP01000115_gene363	1.092e-107	361.0	COG1459@1|root,COG1459@2|Bacteria,2NP2J@2323|unclassified Bacteria	2|Bacteria	U	Type II secretion system (T2SS), protein F	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
CMS2_k127_197547_11	1379698.RBG1_1C00001G1740	1.584e-58	223.0	COG3852@1|root,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_8,PAS_9
CMS2_k127_197547_7	1047013.AQSP01000115_gene361	1.013e-147	481.0	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	nla19	-	-	ko:K07713,ko:K07714,ko:K19641	ko02020,map02020	M00499,M00500,M00772	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_197547_12	941824.TCEL_00174	1.514e-41	159.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia,36IU5@31979|Clostridiaceae	186801|Clostridia	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
CMS2_k127_197547_3	589865.DaAHT2_1111	4.585e-205	659.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
CMS2_k127_197547_5	1125863.JAFN01000001_gene2044	9.017e-200	640.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
CMS2_k127_197547_1	1047013.AQSP01000101_gene609	0.0	1257.0	COG4447@1|root,COG4447@2|Bacteria,2NQN9@2323|unclassified Bacteria	2|Bacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	BNR,BNR_6,Sortilin-Vps10
CMS2_k127_197547_0	536232.CLM_0373	0.0	1871.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1977683_15	1121448.DGI_2435	6.07e-05	56.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,42P4F@68525|delta/epsilon subdivisions,2WJVT@28221|Deltaproteobacteria,2MFYV@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
CMS2_k127_1977683_4	1499967.BAYZ01000125_gene2601	5.02e-74	256.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
CMS2_k127_1977683_2	1408422.JHYF01000017_gene1871	0.0	1122.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1977683_0	1042163.BRLA_c025640	0.0	1978.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_1977683_1	1121121.KB894289_gene2673	0.0	1270.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_31,PP-binding
CMS2_k127_1977683_6	744872.Spica_0564	3.513e-35	138.0	COG1487@1|root,COG1487@2|Bacteria,2JAUP@203691|Spirochaetes	203691|Spirochaetes	S	PIN domain	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
CMS2_k127_1977683_11	671143.DAMO_1705	1.028e-16	84.0	COG1708@1|root,COG1708@2|Bacteria,2NRXI@2323|unclassified Bacteria	2|Bacteria	S	Nucleotidyltransferase domain	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	HEPN,NTP_transf_2
CMS2_k127_1977683_7	1123376.AUIU01000017_gene105	8.485e-33	134.0	COG3465@1|root,COG3465@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
CMS2_k127_1977683_3	1089553.Tph_c02820	8.798e-116	386.0	COG1078@1|root,COG1078@2|Bacteria,1TPVB@1239|Firmicutes,24DGJ@186801|Clostridia,42FPH@68295|Thermoanaerobacterales	186801|Clostridia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
CMS2_k127_1977683_13	41431.PCC8801_3235	6.648e-09	65.0	COG0790@1|root,COG0790@2|Bacteria,1GA1W@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM T5orf172 domain	-	-	-	-	-	-	-	-	-	-	-	-	T5orf172
CMS2_k127_1977683_14	177437.HRM2_44710	5.936e-05	47.0	COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria	1224|Proteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1977683_5	693661.Arcve_1274	5.366e-42	158.0	COG2361@1|root,arCOG05024@2157|Archaea,2Y6HF@28890|Euryarchaeota,246HB@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
CMS2_k127_1977683_8	693661.Arcve_1273	1.879e-31	126.0	COG1669@1|root,arCOG01206@2157|Archaea,2Y02Z@28890|Euryarchaeota,246IH@183980|Archaeoglobi	183980|Archaeoglobi	S	DNA polymerase beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
CMS2_k127_1977683_10	99598.Cal7507_3549	3.164e-23	104.0	COG3620@1|root,COG3620@2|Bacteria,1G8FJ@1117|Cyanobacteria,1HPN3@1161|Nostocales	1117|Cyanobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_37
CMS2_k127_1977683_9	329726.AM1_6368	2.375e-24	103.0	COG4683@1|root,COG4683@2|Bacteria,1GHR5@1117|Cyanobacteria	1117|Cyanobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
CMS2_k127_1989601_1	227377.CBU_1820	3.569e-39	153.0	2BHMV@1|root,32BQM@2|Bacteria,1N9I1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1989601_2	237368.SCABRO_01455	8.97e-39	145.0	2CCWK@1|root,2ZGSH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1989601_5	631362.Thi970DRAFT_02904	3.202e-09	60.0	2FFE4@1|root,347BQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1989601_3	272123.Anacy_4920	1.85e-35	137.0	2A03C@1|root,30N5V@2|Bacteria,1GJWZ@1117|Cyanobacteria,1HSS1@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1989601_0	272123.Anacy_4919	4.392e-53	191.0	2FFE4@1|root,347BQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2034684_0	536232.CLM_0373	0.0	1945.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2034684_6	1291050.JAGE01000001_gene2515	1.9e-187	636.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WNP0@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_2034684_10	714943.Mucpa_2436	4.028e-164	533.0	COG2192@1|root,COG2192@2|Bacteria,4NEV9@976|Bacteroidetes,1IP8X@117747|Sphingobacteriia	976|Bacteroidetes	O	PFAM Carbamoyltransferase	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS2_k127_2034684_13	1254432.SCE1572_19765	7.123e-119	396.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,42NGU@68525|delta/epsilon subdivisions,2WIM5@28221|Deltaproteobacteria,2YVCR@29|Myxococcales	28221|Deltaproteobacteria	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS2_k127_2034684_40	706587.Desti_1758	1.07e-42	174.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria,2MS34@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_2034684_20	1499967.BAYZ01000026_gene1635	9.914e-91	304.0	COG1335@1|root,COG1335@2|Bacteria,2NRGH@2323|unclassified Bacteria	2|Bacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS2_k127_2034684_60	309803.CTN_1409	5.951e-18	96.0	COG0635@1|root,COG0635@2|Bacteria,2GCD2@200918|Thermotogae	200918|Thermotogae	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS2_k127_2034684_58	1121440.AUMA01000006_gene1636	9.341e-20	103.0	2AIEX@1|root,318WD@2|Bacteria,1Q12P@1224|Proteobacteria,43EUP@68525|delta/epsilon subdivisions,2X1TI@28221|Deltaproteobacteria,2MFNH@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2034684_50	1206744.BAGL01000063_gene4691	2.397e-31	139.0	COG4916@1|root,COG4916@2|Bacteria,2ISNW@201174|Actinobacteria	201174|Actinobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
CMS2_k127_2034684_36	870187.Thini_1430	1.492e-48	183.0	COG4700@1|root,COG4700@2|Bacteria,1R577@1224|Proteobacteria,1S3I7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria containing a divergent form of TPR repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_6
CMS2_k127_2034684_17	118161.KB235922_gene1747	5.163e-99	329.0	COG0500@1|root,COG2226@2|Bacteria,1G4C1@1117|Cyanobacteria,3VN9M@52604|Pleurocapsales	1117|Cyanobacteria	Q	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS2_k127_2034684_53	639282.DEFDS_2016	1.369e-26	118.0	COG2253@1|root,COG2253@2|Bacteria	2|Bacteria	V	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS2_k127_2034684_70	743722.Sph21_1528	5.945e-06	49.0	COG1487@1|root,COG1487@2|Bacteria,4NVNV@976|Bacteroidetes,1ITWZ@117747|Sphingobacteriia	976|Bacteroidetes	S	PIN domain	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_2034684_61	671143.DAMO_1703	3.815e-16	79.0	COG5450@1|root,COG5450@2|Bacteria	2|Bacteria	K	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
CMS2_k127_2034684_62	439235.Dalk_1464	2.728e-15	78.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales	1224|Proteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
CMS2_k127_2034684_37	272134.KB731324_gene4380	6.232e-48	179.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	BcsB,DUF2064,Glycos_transf_2,LicD,Methyltransf_21
CMS2_k127_2034684_12	1177928.TH2_17481	5.012e-138	447.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2TSIP@28211|Alphaproteobacteria,2JPR1@204441|Rhodospirillales	204441|Rhodospirillales	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS2_k127_2034684_4	56780.SYN_00532	5.951e-213	669.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2WJ3T@28221|Deltaproteobacteria,2MQAM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS2_k127_2034684_5	880073.Calab_0773	1.733e-200	642.0	COG0449@1|root,COG0449@2|Bacteria,2NNWC@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
CMS2_k127_2034684_3	313606.M23134_06826	3.455e-244	768.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,47MV2@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
CMS2_k127_2034684_56	561177.ANHYDRO_00182	8.867e-24	119.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,22GF2@1570339|Peptoniphilaceae	186801|Clostridia	KLT	Kinase domain protein	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_2034684_9	313606.M23134_07246	1.831e-177	595.0	COG2203@1|root,COG2208@1|root,COG3292@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3292@2|Bacteria,4NKGA@976|Bacteroidetes,47TQU@768503|Cytophagia	976|Bacteroidetes	T	Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,SpoIIE,Y_Y_Y
CMS2_k127_2034684_28	1479237.JMLY01000001_gene2547	4.103e-65	233.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,1RREJ@1236|Gammaproteobacteria,4663C@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	xylanase chitin deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
CMS2_k127_2034684_44	459349.CLOAM1842	1.239e-39	156.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_31
CMS2_k127_2034684_22	765912.Thimo_3486	1.121e-79	276.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	MetW,Methyltransf_11,Methyltransf_23
CMS2_k127_2034684_23	401053.AciPR4_3593	1.533e-77	271.0	COG0463@1|root,COG0463@2|Bacteria,3Y4P3@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
CMS2_k127_2034684_30	864702.OsccyDRAFT_1066	6.715e-64	241.0	2EQPR@1|root,32552@2|Bacteria,1GE2R@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2034684_16	938709.AUSH02000016_gene636	3.733e-100	339.0	COG0463@1|root,COG0463@2|Bacteria,4NGGM@976|Bacteroidetes	976|Bacteroidetes	M	glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
CMS2_k127_2034684_35	1047013.AQSP01000121_gene2694	2.075e-49	194.0	COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_2034684_42	1047013.AQSP01000106_gene1773	1.52e-40	170.0	COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4976,Sulfatase
CMS2_k127_2034684_41	1267535.KB906767_gene5244	3.966e-41	172.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Glyco_tranf_2_3,Glycos_transf_2,Sulfatase
CMS2_k127_2034684_65	1123288.SOV_1c07870	2.901e-12	79.0	COG3307@1|root,COG3307@2|Bacteria,1TQGY@1239|Firmicutes,4H249@909932|Negativicutes	909932|Negativicutes	M	O-antigen polymerase	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	Wzy_C
CMS2_k127_2034684_8	518766.Rmar_1136	1.961e-179	566.0	COG0451@1|root,COG0451@2|Bacteria,4NDX8@976|Bacteroidetes	976|Bacteroidetes	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	Epimerase
CMS2_k127_2034684_67	1166018.FAES_0771	1.841e-09	70.0	2C5DJ@1|root,331B5@2|Bacteria,4P6KK@976|Bacteroidetes,47VVF@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2034684_18	1123248.KB893323_gene1594	9.224e-97	327.0	COG1922@1|root,COG1922@2|Bacteria,4NJGT@976|Bacteroidetes,1IYUZ@117747|Sphingobacteriia	976|Bacteroidetes	M	Glycosyl transferase WecB/TagA/CpsF family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
CMS2_k127_2034684_11	41431.PCC8801_3362	4.022e-156	502.0	COG0438@1|root,COG0438@2|Bacteria,1G3U9@1117|Cyanobacteria,3KJIG@43988|Cyanothece	1117|Cyanobacteria	H	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_2034684_51	1121897.AUGO01000008_gene2635	4.424e-30	123.0	2A8XB@1|root,30Y0U@2|Bacteria,4NSDA@976|Bacteroidetes,1I4EZ@117743|Flavobacteriia,2NY54@237|Flavobacterium	976|Bacteroidetes	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
CMS2_k127_2034684_72	102232.GLO73106DRAFT_00028040	5.818e-05	55.0	COG3307@1|root,COG3307@2|Bacteria,1G1ZH@1117|Cyanobacteria	1117|Cyanobacteria	M	bicarbonate transporter, IctB family	ictB	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	Wzy_C
CMS2_k127_2034684_48	1267535.KB906767_gene4838	3.273e-38	163.0	COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
CMS2_k127_2034684_29	497964.CfE428DRAFT_0088	3.702e-64	229.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_2034684_55	1487953.JMKF01000088_gene5475	2.173e-25	122.0	2C5DJ@1|root,331B5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2034684_43	1047013.AQSP01000123_gene1525	3.818e-40	169.0	COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria,2NPK1@2323|unclassified Bacteria	2|Bacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
CMS2_k127_2034684_71	880070.Cycma_0774	2.046e-05	57.0	COG0438@1|root,COG0438@2|Bacteria,4NSRB@976|Bacteroidetes	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
CMS2_k127_2034684_25	32049.SYNPCC7002_A0408	3.419e-71	256.0	COG0438@1|root,COG0438@2|Bacteria,1G1VE@1117|Cyanobacteria,1H0Z0@1129|Synechococcus	1117|Cyanobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_2034684_31	1232410.KI421416_gene2565	5.301e-62	229.0	COG1216@1|root,COG1216@2|Bacteria,1RDAK@1224|Proteobacteria,42U4I@68525|delta/epsilon subdivisions,2WQB2@28221|Deltaproteobacteria,43UVR@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_2034684_39	1121342.AUCO01000010_gene2256	1.212e-43	170.0	COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia,36E2P@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
CMS2_k127_2034684_34	1121342.AUCO01000010_gene2257	1.548e-50	183.0	COG1898@1|root,COG1898@2|Bacteria,1V4G5@1239|Firmicutes,24IZ8@186801|Clostridia	186801|Clostridia	M	dTDP-4-dehydrorhamnose 3,5-epimerase	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
CMS2_k127_2034684_14	469618.FVAG_02101	6.716e-116	383.0	COG0451@1|root,COG0451@2|Bacteria,379AQ@32066|Fusobacteria	32066|Fusobacteria	M	Polysaccharide biosynthesis protein	-	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
CMS2_k127_2034684_15	1293054.HSACCH_02454	1.275e-107	355.0	COG1208@1|root,COG1208@2|Bacteria,1TPII@1239|Firmicutes,249GT@186801|Clostridia	186801|Clostridia	JM	Glucose-1-phosphate cytidylyltransferase	rfbF	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
CMS2_k127_2034684_45	1303518.CCALI_00669	1.438e-39	168.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Glyco_tranf_2_3,Glycos_transf_2,Sulfatase
CMS2_k127_2034684_73	1167006.UWK_01729	8.883e-05	52.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH,HTH_18
CMS2_k127_2034684_24	655812.HMPREF0061_0431	2.033e-71	253.0	COG0189@1|root,COG0189@2|Bacteria,1UIBP@1239|Firmicutes	1239|Firmicutes	HJ	carbamoylphosphate synthase large subunit	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_3
CMS2_k127_2034684_33	655812.HMPREF0061_0432	2.616e-52	193.0	COG0639@1|root,COG0639@2|Bacteria,1UYWK@1239|Firmicutes	1239|Firmicutes	T	COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
CMS2_k127_2034684_66	498761.HM1_1189	1.539e-11	74.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia	186801|Clostridia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
CMS2_k127_2034684_27	330214.NIDE2997	6.323e-68	242.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
CMS2_k127_2034684_46	644282.Deba_1034	3.325e-39	165.0	COG1032@1|root,COG3063@1|root,COG1032@2|Bacteria,COG3063@2|Bacteria,1MWR0@1224|Proteobacteria,42TFM@68525|delta/epsilon subdivisions,2WPBE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_2034684_21	439235.Dalk_0237	4.319e-82	309.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_2034684_64	1144275.COCOR_01607	8.157e-13	83.0	COG3568@1|root,COG3568@2|Bacteria,1N2ZJ@1224|Proteobacteria,42WUR@68525|delta/epsilon subdivisions,2WSUA@28221|Deltaproteobacteria,2YUA6@29|Myxococcales	28221|Deltaproteobacteria	PQ	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,LTD
CMS2_k127_2034684_38	498848.TaqDRAFT_4878	1.058e-47	198.0	COG4447@1|root,COG4447@2|Bacteria,1WJIB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2034684_32	498211.CJA_1645	1.508e-57	226.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1T4K6@1236|Gammaproteobacteria,1FGY3@10|Cellvibrio	1236|Gammaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	ppkA	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase,PEGA,Pkinase
CMS2_k127_2034684_52	237368.SCABRO_03544	6.169e-29	135.0	COG0515@1|root,COG0666@1|root,COG0790@1|root,COG0515@2|Bacteria,COG0666@2|Bacteria,COG0790@2|Bacteria,2J1KC@203682|Planctomycetes	2|Bacteria	KLT	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4,Sel1,TPR_16,TPR_19,TonB_C
CMS2_k127_2034684_1	269797.Mbar_A2710	0.0	1443.0	COG0178@1|root,arCOG04694@2157|Archaea,2XTDU@28890|Euryarchaeota,2N9EN@224756|Methanomicrobia	224756|Methanomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS2_k127_2034684_7	269797.Mbar_A2709	5.02e-186	597.0	COG0322@1|root,arCOG04753@2157|Archaea,2XTH1@28890|Euryarchaeota,2N9EV@224756|Methanomicrobia	224756|Methanomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,UVR,UvrC_HhH_N
CMS2_k127_2034684_47	1384056.N787_00800	4.384e-39	157.0	COG1075@1|root,COG1075@2|Bacteria,1P9JY@1224|Proteobacteria,1RYH4@1236|Gammaproteobacteria,1X4KM@135614|Xanthomonadales	135614|Xanthomonadales	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2034684_63	411469.EUBHAL_00274	3.019e-13	70.0	COG2865@1|root,COG2865@2|Bacteria,1TRTZ@1239|Firmicutes,25CHW@186801|Clostridia,25Z5N@186806|Eubacteriaceae	186801|Clostridia	K	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2,HATPase_c_4,HTH_24
CMS2_k127_2034684_68	717772.THIAE_08690	2.796e-09	64.0	COG1522@1|root,COG2865@1|root,COG1522@2|Bacteria,COG2865@2|Bacteria,1R4MD@1224|Proteobacteria,1S1XQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4062,HATPase_c_4
CMS2_k127_2034684_2	521011.Mpal_1821	1.972e-303	942.0	COG0556@1|root,arCOG04748@2157|Archaea,2XTM8@28890|Euryarchaeota,2NAF4@224756|Methanomicrobia	224756|Methanomicrobia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
CMS2_k127_2034684_26	1047013.AQSP01000138_gene1055	1.401e-69	263.0	2DTK7@1|root,33KQU@2|Bacteria,2NRAS@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2034684_19	880073.Calab_0031	2.698e-95	317.0	COG2017@1|root,COG2017@2|Bacteria,2NQA5@2323|unclassified Bacteria	2|Bacteria	G	Converts alpha-aldose to the beta-anomer	mro	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
CMS2_k127_2035673_10	1120968.AUBX01000011_gene3101	1.547e-39	151.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	wrbA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red,Flavodoxin_1,Flavodoxin_5,YjgF_endoribonc
CMS2_k127_2035673_9	247490.KSU1_C0143	3.595e-69	252.0	COG1032@1|root,COG1032@2|Bacteria,2J1W3@203682|Planctomycetes	203682|Planctomycetes	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
CMS2_k127_2035673_8	237368.SCABRO_01661	1.152e-69	241.0	COG1611@1|root,COG1611@2|Bacteria,2IZK9@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS2_k127_2035673_11	1047013.AQSP01000137_gene564	6.202e-37	140.0	COG1143@1|root,COG1143@2|Bacteria,2NQ1E@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S binding domain	vorC	-	1.2.7.3,1.6.5.3	ko:K00176,ko:K00338	ko00020,ko00190,ko00720,ko01100,ko01120,ko01200,map00020,map00190,map00720,map01100,map01120,map01200	M00009,M00011,M00144,M00173,M00620	R01197,R11945	RC00004,RC00061,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_4,Fer4_7
CMS2_k127_2035673_5	1047013.AQSP01000137_gene563	1.31e-179	567.0	COG0674@1|root,COG0674@2|Bacteria,2NNWT@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	vorB	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00174,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
CMS2_k127_2035673_6	1047013.AQSP01000137_gene562	3.61e-144	459.0	COG1013@1|root,COG1013@2|Bacteria,2NNMC@2323|unclassified Bacteria	2|Bacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	vorB	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00175,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
CMS2_k127_2035673_7	1047013.AQSP01000137_gene561	1.031e-80	271.0	COG1014@1|root,COG1014@2|Bacteria,2NPQW@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	porG	-	1.2.7.3,1.2.7.7	ko:K00177,ko:K00187	ko00020,ko00280,ko00720,ko01100,ko01120,ko01200,map00020,map00280,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197,R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
CMS2_k127_2035673_4	1237149.C900_05793	2.822e-291	926.0	COG1680@1|root,COG4615@1|root,COG1680@2|Bacteria,COG4615@2|Bacteria,4NJ17@976|Bacteroidetes	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,Beta-lactamase
CMS2_k127_2035673_2	1121121.KB894307_gene2066	2.712e-315	1012.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2035673_1	1536774.H70357_19025	0.0	1531.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_2035673_3	358681.BBR47_27890	2.077e-296	956.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2035673_0	1195236.CTER_1424	0.0	1719.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_2035673_12	1121121.KB894288_gene2765	2.726e-05	49.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_2063469_7	1408422.JHYF01000003_gene809	2.053e-139	457.0	COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,248UK@186801|Clostridia,36DHD@31979|Clostridiaceae	186801|Clostridia	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
CMS2_k127_2063469_19	1232410.KI421424_gene1593	1.608e-40	157.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,42NSS@68525|delta/epsilon subdivisions,2WQNJ@28221|Deltaproteobacteria,43UXT@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
CMS2_k127_2063469_6	392500.Swoo_2854	5.251e-165	542.0	COG0457@1|root,COG0457@2|Bacteria,1PBYW@1224|Proteobacteria,1SWS0@1236|Gammaproteobacteria,2QDGR@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
CMS2_k127_2063469_20	526222.Desal_3269	2.692e-28	120.0	COG3695@1|root,COG3695@2|Bacteria,1N7J2@1224|Proteobacteria,42VQ4@68525|delta/epsilon subdivisions,2WS47@28221|Deltaproteobacteria,2MGUU@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM Methylated-DNA- protein -cysteine	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
CMS2_k127_2063469_2	1249997.JHZW01000003_gene3241	8.049e-233	769.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,1HZEZ@117743|Flavobacteriia,2PI0Z@252356|Maribacter	976|Bacteroidetes	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_2063469_17	382464.ABSI01000013_gene1939	3.186e-53	201.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4,NAD_binding_4
CMS2_k127_2063469_10	1499967.BAYZ01000050_gene2873	5.532e-112	368.0	COG1230@1|root,COG1230@2|Bacteria,2NPC3@2323|unclassified Bacteria	2|Bacteria	U	Cation efflux family	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux,ZT_dimer
CMS2_k127_2063469_12	497964.CfE428DRAFT_1494	7.417e-105	349.0	COG0123@1|root,COG0123@2|Bacteria,46SMT@74201|Verrucomicrobia	74201|Verrucomicrobia	BQ	Histone deacetylase domain	acuC	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
CMS2_k127_2063469_23	1047013.AQSP01000114_gene684	1.122e-20	105.0	COG1629@1|root,COG2304@1|root,COG1629@2|Bacteria,COG2304@2|Bacteria,2NQ3W@2323|unclassified Bacteria	2|Bacteria	P	von Willebrand factor type A domain	yfbK	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	CarbopepD_reg_2,DUF3520,Plug,VWA,vWF_A
CMS2_k127_2063469_16	869213.JCM21142_41386	9.496e-56	203.0	COG2043@1|root,COG2043@2|Bacteria	2|Bacteria	C	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
CMS2_k127_2063469_3	1123279.ATUS01000005_gene3241	3.752e-196	617.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1J4ZH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
CMS2_k127_2063469_14	401526.TcarDRAFT_0626	8.934e-97	327.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,4H2S4@909932|Negativicutes	2|Bacteria	C	binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4
CMS2_k127_2063469_4	926692.AZYG01000051_gene1861	1.975e-191	608.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,3WB7J@53433|Halanaerobiales	186801|Clostridia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
CMS2_k127_2063469_0	1125863.JAFN01000001_gene2270	3.16e-322	1007.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
CMS2_k127_2063469_15	882.DVU_3395	2.529e-77	276.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42MNF@68525|delta/epsilon subdivisions,2WIYR@28221|Deltaproteobacteria,2M9ZU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CMS2_k127_2063469_21	1307761.L21SP2_2915	2.983e-22	102.0	COG1959@1|root,COG1959@2|Bacteria,2J8PQ@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
CMS2_k127_2063469_1	1191523.MROS_0344	3.191e-251	781.0	COG0719@1|root,COG0719@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	sufB	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	iAPECO1_1312.APECO1_760,iECH74115_1262.ECH74115_2397,iECSF_1327.ECSF_1543,iECSP_1301.ECSP_2250,iUTI89_1310.UTI89_C1875,ic_1306.c2078	UPF0051
CMS2_k127_2063469_11	472759.Nhal_0689	4.965e-111	363.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1WWC1@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM FeS assembly ATPase SufC	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
CMS2_k127_2063469_13	105559.Nwat_0646	1.032e-104	355.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1WWK5@135613|Chromatiales	135613|Chromatiales	O	FeS assembly protein SufD	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
CMS2_k127_2063469_5	323261.Noc_2487	3.827e-177	563.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1WWTN@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,SufE
CMS2_k127_2063469_18	314278.NB231_04900	7.47e-48	175.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,1WW3I@135613|Chromatiales	135613|Chromatiales	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488,ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
CMS2_k127_2063469_24	344747.PM8797T_28574	1.211e-15	82.0	2BRP6@1|root,32KNT@2|Bacteria,2J4GX@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2063469_8	398579.Spea_1685	2.551e-137	465.0	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria,2QAPJ@267890|Shewanellaceae	1236|Gammaproteobacteria	H	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_2063469_22	398512.JQKC01000009_gene568	3.354e-22	97.0	COG1020@1|root,COG1020@2|Bacteria,1V12Q@1239|Firmicutes,24ER3@186801|Clostridia,3WNBS@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,PP-binding,QueC,Radical_SAM
CMS2_k127_2063469_9	1121121.KB894288_gene2764	1.478e-133	446.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2068975_1	383372.Rcas_3821	4.168e-18	100.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,2GBRR@200795|Chloroflexi,376B2@32061|Chloroflexia	32061|Chloroflexia	D	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like,VWA_2
CMS2_k127_2068975_0	760192.Halhy_5981	4.701e-36	151.0	COG0714@1|root,COG0714@2|Bacteria,4NIHC@976|Bacteroidetes,1IQRD@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM ATPase associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_5
CMS2_k127_2070632_1	945713.IALB_3167	1.733e-07	57.0	COG0457@1|root,COG0457@2|Bacteria	945713.IALB_3167|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2070632_0	760192.Halhy_3247	1.465e-94	319.0	COG1680@1|root,COG1680@2|Bacteria,4NFUI@976|Bacteroidetes,1INWP@117747|Sphingobacteriia	976|Bacteroidetes	V	COGs COG1680 Beta-lactamase class C and other penicillin binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
CMS2_k127_2097144_9	391612.CY0110_07809	4.18e-64	231.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,3KJ4W@43988|Cyanothece	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2097144_0	1144275.COCOR_02595	0.0	1771.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions,2WN7A@28221|Deltaproteobacteria,2YTZA@29|Myxococcales	28221|Deltaproteobacteria	Q	non-ribosomal peptide synthetase	-	-	-	ko:K16416	ko01052,map01052	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2097144_6	521045.Kole_0619	6.142e-95	322.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016999,GO:0017000,GO:0017144,GO:0044237,GO:0044249	-	ko:K21785	ko00333,ko01130,map00333,map01130	M00837,M00838	R11668,R11669	-	ko00000,ko00001,ko00002	-	-	-	Nitroreductase
CMS2_k127_2097144_3	756499.Desde_0761	1.722e-114	384.0	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia,263EX@186807|Peptococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_2097144_4	756499.Desde_0761	7.303e-112	377.0	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia,263EX@186807|Peptococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_2097144_11	1232453.BAIF02000015_gene3218	2.538e-22	104.0	28WZY@1|root,2ZIYW@2|Bacteria,1UZ8B@1239|Firmicutes,24GR5@186801|Clostridia	186801|Clostridia	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
CMS2_k127_2097144_5	1007103.AFHW01000032_gene2242	1.234e-109	366.0	COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,4HW8T@91061|Bacilli,26W7T@186822|Paenibacillaceae	91061|Bacilli	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
CMS2_k127_2097144_8	172088.AUGA01000066_gene6903	4.462e-86	292.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,2U7ZW@28211|Alphaproteobacteria,3K2QM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
CMS2_k127_2097144_10	44251.PDUR_16040	1.231e-47	186.0	COG1775@1|root,COG1775@2|Bacteria,1TS7H@1239|Firmicutes,4I6EW@91061|Bacilli,26SJ1@186822|Paenibacillaceae	91061|Bacilli	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
CMS2_k127_2097144_2	1174528.JH992891_gene302	2.495e-236	788.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria	1117|Cyanobacteria	Q	Amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,PilZ,Thioesterase
CMS2_k127_2097144_7	244582.JQAK01000001_gene1838	2.408e-86	326.0	COG0454@1|root,COG3321@1|root,COG0456@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2UR2U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3321 Polyketide synthase modules and related proteins	-	-	-	ko:K13613,ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	AMP-binding,Acyl_transf_1,Bac_luciferase,Condensation,ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
CMS2_k127_2097144_1	882378.RBRH_02576	6.118e-307	1018.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2VP69@28216|Betaproteobacteria,1K2WK@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	PKS_DH	rhiD	-	-	ko:K15677	-	-	-	-	ko00000,ko01008	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_2100676_2	118005.AWNK01000004_gene1064	0.0	1148.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2100676_5	398512.JQKC01000015_gene4638	2.191e-249	784.0	COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia,3WHGT@541000|Ruminococcaceae	186801|Clostridia	E	asparagine synthase (glutamine-hydrolyzing)	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7,NAD_synthase
CMS2_k127_2100676_11	755731.Clo1100_0895	1.424e-78	301.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,Thioesterase,ketoacyl-synt
CMS2_k127_2100676_6	118005.AWNK01000004_gene1064	8.539e-199	686.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2100676_9	1117108.PAALTS15_22603	1.896e-115	422.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2100676_4	1244869.H261_05239	1.068e-274	864.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VF1V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NAD_binding_1
CMS2_k127_2100676_8	398512.JQKC01000015_gene4634	9.23e-135	440.0	COG0826@1|root,COG0826@2|Bacteria,1VT69@1239|Firmicutes,25DBH@186801|Clostridia	186801|Clostridia	O	Peptidase family U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
CMS2_k127_2100676_1	649747.HMPREF0083_00279	0.0	1545.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16123,ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2100676_3	1121121.KB894307_gene2065	2.577e-313	1004.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16123	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_2100676_0	536232.CLM_0374	0.0	1973.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2100676_22	1123229.AUBC01000001_gene1444	1.515e-15	84.0	COG0077@1|root,COG0077@2|Bacteria,1MYWM@1224|Proteobacteria,2U827@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Prephenate dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2100676_12	1121448.DGI_0093	2.703e-57	219.0	COG1032@1|root,COG1032@2|Bacteria,1NRWP@1224|Proteobacteria,42S72@68525|delta/epsilon subdivisions,2WNA6@28221|Deltaproteobacteria,2M7RD@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_2100676_15	1463936.JOJI01000002_gene2998	2.44e-35	153.0	COG1032@1|root,COG1032@2|Bacteria,2IEAV@201174|Actinobacteria	201174|Actinobacteria	C	radical SAM domain protein	-	-	-	ko:K21224	ko01059,ko01130,map01059,map01130	M00831	R11389	RC03430	ko00000,ko00001,ko00002	-	-	-	B12-binding,Radical_SAM
CMS2_k127_2100676_14	1869.MB27_08940	6.881e-41	164.0	296TN@1|root,2ZU2M@2|Bacteria,2IB0Z@201174|Actinobacteria,4DIR9@85008|Micromonosporales	201174|Actinobacteria	S	Sulfotransferase family	-	-	-	ko:K18571	ko00332,ko01130,map00332,map01130	-	R10751	RC00007,RC00518	ko00000,ko00001,ko01000	-	-	-	Sulfotransfer_3
CMS2_k127_2100676_7	118005.AWNK01000004_gene1064	1.974e-186	597.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2100676_19	1499967.BAYZ01000159_gene506	2.703e-21	97.0	28JE3@1|root,2Z98B@2|Bacteria,2NQ8M@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS2_k127_2100676_13	247490.KSU1_A0022	1.209e-42	159.0	COG4226@1|root,COG4226@2|Bacteria,2J4R0@203682|Planctomycetes	203682|Planctomycetes	S	protein encoded in hypervariable junctions of pilus gene clusters	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2100676_23	261292.Nit79A3_0541	1.139e-14	77.0	COG5304@1|root,COG5304@2|Bacteria,1NBCZ@1224|Proteobacteria,2W4RK@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2100676_18	748247.AZKH_4105	3.197e-22	97.0	COG2929@1|root,COG2929@2|Bacteria,1N8PW@1224|Proteobacteria,2W408@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	BrnT_toxin
CMS2_k127_2100676_17	1170562.Cal6303_2903	3.233e-28	116.0	COG3668@1|root,COG3668@2|Bacteria,1G8NI@1117|Cyanobacteria,1HU70@1161|Nostocales	1117|Cyanobacteria	S	PFAM plasmid	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
CMS2_k127_2100676_21	65093.PCC7418_3630	8.18e-17	81.0	2E9VI@1|root,3341D@2|Bacteria,1GRB3@1117|Cyanobacteria	1117|Cyanobacteria	S	Addiction module component, TIGR02574 family	-	-	-	-	-	-	-	-	-	-	-	-	Unstab_antitox
CMS2_k127_2100676_24	760192.Halhy_2444	2.79e-12	70.0	COG1672@1|root,COG1672@2|Bacteria,4P12U@976|Bacteroidetes	2|Bacteria	S	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,DUF1822,PDDEXK_9
CMS2_k127_2100676_25	1519464.HY22_03905	2.335e-11	70.0	COG3437@1|root,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Response_reg
CMS2_k127_2100676_10	1121904.ARBP01000003_gene6377	3.119e-82	308.0	COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HAMP,HATPase_c,HisKA,PAS,PAS_9,Reg_prop,SpoIIE,TPR_12,Y_Y_Y
CMS2_k127_2100676_20	203124.Tery_3155	2.048e-19	93.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG2203@1|root,COG3437@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,1G0F6@1117|Cyanobacteria,1H7AR@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	cyaC	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,Guanylate_cyc,HATPase_c,HisKA,Response_reg
CMS2_k127_2106659_0	509191.AEDB02000067_gene921	0.0	1373.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2108072_0	744872.Spica_0617	5.885e-46	168.0	COG2233@1|root,COG2233@2|Bacteria,2J5WY@203691|Spirochaetes	203691|Spirochaetes	F	Uracil permease	-	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
CMS2_k127_2108072_2	85643.Tmz1t_0463	4.584e-26	123.0	COG5549@1|root,COG5635@1|root,COG5549@2|Bacteria,COG5635@2|Bacteria,1R9BR@1224|Proteobacteria,2VPTQ@28216|Betaproteobacteria,2KYZT@206389|Rhodocyclales	28216|Betaproteobacteria	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	Astacin,PPC
CMS2_k127_2108072_1	1379698.RBG1_1C00001G1616	1.838e-38	160.0	COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria	2|Bacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_8
CMS2_k127_2115827_1	324925.Ppha_2430	1.871e-10	68.0	COG0455@1|root,COG5635@1|root,COG0455@2|Bacteria,COG5635@2|Bacteria	2|Bacteria	T	Nacht domain	-	-	-	ko:K02282,ko:K03321	-	-	-	-	ko00000,ko02000,ko02035,ko02044	2.A.53.3	-	-	CbiA,NACHT,Pentapeptide,WD40,Wzz
CMS2_k127_2115827_0	795359.TOPB45_0665	6.478e-95	327.0	COG2204@1|root,COG2204@2|Bacteria,2GHIR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_2133261_0	177437.HRM2_34080	2.021e-56	224.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,1N26H@1224|Proteobacteria,43EV4@68525|delta/epsilon subdivisions,2WR4K@28221|Deltaproteobacteria,2MNP4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS2_k127_2133261_1	1101195.Meth11DRAFT_1112	6.894e-16	93.0	COG1409@1|root,COG5635@1|root,COG1409@2|Bacteria,COG5635@2|Bacteria	2|Bacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,NACHT,Pentapeptide
CMS2_k127_214710_1	933262.AXAM01000017_gene3111	1.188e-89	303.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MJ29@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_3
CMS2_k127_214710_2	1121935.AQXX01000072_gene5	5.038e-52	209.0	COG1994@1|root,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria,1RQY8@1236|Gammaproteobacteria,1XIRU@135619|Oceanospirillales	135619|Oceanospirillales	S	COG1994 Zn-dependent proteases	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_214710_0	929562.Emtol_0801	8.494e-113	373.0	COG1816@1|root,COG1816@2|Bacteria,4NJ8S@976|Bacteroidetes	976|Bacteroidetes	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	-	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
CMS2_k127_2165350_13	517418.Ctha_1486	7.534e-15	83.0	2EEYB@1|root,338RQ@2|Bacteria,1FF1Q@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2165350_5	99598.Cal7507_2101	3.219e-62	226.0	COG5464@1|root,COG5464@2|Bacteria,1G2UF@1117|Cyanobacteria,1HMUW@1161|Nostocales	1117|Cyanobacteria	S	transposase or invertase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
CMS2_k127_2165350_9	1121403.AUCV01000017_gene4486	4.584e-24	106.0	COG2944@1|root,COG2944@2|Bacteria,1N66H@1224|Proteobacteria,42UQW@68525|delta/epsilon subdivisions,2WQQF@28221|Deltaproteobacteria,2MKNP@213118|Desulfobacterales	28221|Deltaproteobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS2_k127_2165350_0	1094508.Tsac_0416	4.616e-137	451.0	COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,42FNW@68295|Thermoanaerobacterales	186801|Clostridia	C	belongs to the iron- containing alcohol dehydrogenase family	adhE	-	1.1.1.1,1.2.1.10	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
CMS2_k127_2165350_6	1069080.KB913028_gene889	1.518e-29	123.0	COG2172@1|root,COG2172@2|Bacteria,1UJ84@1239|Firmicutes,4H9AW@909932|Negativicutes	909932|Negativicutes	T	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
CMS2_k127_2165350_4	706587.Desti_2743	8.907e-75	261.0	COG2172@1|root,COG2524@1|root,COG2172@2|Bacteria,COG2524@2|Bacteria	2|Bacteria	K	Domain in cystathionine beta-synthase and other proteins.	RsbW	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,HATPase_c,HATPase_c_2
CMS2_k127_2165350_8	706587.Desti_2748	1.891e-25	109.0	COG4109@1|root,COG4109@2|Bacteria	2|Bacteria	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
CMS2_k127_2165350_1	879212.DespoDRAFT_02012	6.098e-110	364.0	COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,2MHQP@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
CMS2_k127_2165350_7	1123278.KB893620_gene3482	3.735e-26	124.0	COG0451@1|root,COG0451@2|Bacteria,4NI6B@976|Bacteroidetes,47UHB@768503|Cytophagia	976|Bacteroidetes	GM	RmlD substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS2_k127_2165350_2	1304880.JAGB01000002_gene1796	6.416e-100	336.0	COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia	186801|Clostridia	C	biosynthesis protein ThiH	thiH	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
CMS2_k127_2165350_3	1304880.JAGB01000002_gene1795	2.307e-95	318.0	COG2022@1|root,COG2022@2|Bacteria,1TQZ1@1239|Firmicutes,247TJ@186801|Clostridia	186801|Clostridia	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
CMS2_k127_2165350_14	1054860.KB913030_gene1533	2.679e-06	51.0	COG2104@1|root,COG2104@2|Bacteria,2GQKM@201174|Actinobacteria	201174|Actinobacteria	H	ThiS family	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
CMS2_k127_2165350_10	123214.PERMA_1860	1.55e-23	101.0	COG2442@1|root,COG2442@2|Bacteria,2G5E0@200783|Aquificae	200783|Aquificae	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
CMS2_k127_2165350_12	504472.Slin_5532	1.312e-20	95.0	COG4634@1|root,COG4634@2|Bacteria,4NYP1@976|Bacteroidetes,47WBN@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2165350_11	313606.M23134_01346	2.41e-21	98.0	COG0642@1|root,COG2208@1|root,COG3292@1|root,COG2205@2|Bacteria,COG2208@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,47Y1B@768503|Cytophagia	976|Bacteroidetes	KT	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,AAA_16,GAF,HATPase_c,HisKA,PAS_3,PAS_9,Pkinase,Response_reg,SpoIIE,Y_Y_Y
CMS2_k127_2172661_2	1121447.JONL01000001_gene457	3.034e-19	87.0	COG3172@1|root,COG3172@2|Bacteria,1MXEI@1224|Proteobacteria,42N4F@68525|delta/epsilon subdivisions,2WKWK@28221|Deltaproteobacteria,2M99H@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Domain of unknown function (DUF4301)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4301
CMS2_k127_2172661_4	1250005.PHEL85_3396	1.263e-14	83.0	COG4271@1|root,COG4271@2|Bacteria,4NKKU@976|Bacteroidetes,1I0UP@117743|Flavobacteriia	976|Bacteroidetes	K	Predicted nucleotide-binding protein containing TIR-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR-like
CMS2_k127_2177469_14	96561.Dole_0842	2.561e-10	75.0	COG3209@1|root,COG3386@1|root,COG3209@2|Bacteria,COG3386@2|Bacteria,1MVV1@1224|Proteobacteria,43AER@68525|delta/epsilon subdivisions,2X5UG@28221|Deltaproteobacteria,2MN6Q@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,NHL,RHS_repeat
CMS2_k127_2177469_7	439235.Dalk_0237	1.572e-94	348.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_2177469_8	1499967.BAYZ01000076_gene838	3.801e-85	291.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS2_k127_2177469_4	1379698.RBG1_1C00001G1677	4.386e-118	388.0	COG3239@1|root,COG3239@2|Bacteria,2NNTZ@2323|unclassified Bacteria	2|Bacteria	I	Fatty acid desaturase	des	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
CMS2_k127_2177469_3	240292.Ava_2971	3.256e-185	621.0	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1HKN5@1161|Nostocales	1117|Cyanobacteria	S	PFAM WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35,WD40
CMS2_k127_2177469_11	631362.Thi970DRAFT_00609	1.485e-52	214.0	COG1672@1|root,COG1672@2|Bacteria,1QVZA@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator, CadC	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_35,TPR_10,Trans_reg_C
CMS2_k127_2177469_6	1047013.AQSP01000122_gene2259	2.092e-106	364.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
CMS2_k127_2177469_5	1047013.AQSP01000137_gene560	1.289e-111	369.0	COG0332@1|root,COG0332@2|Bacteria,2NNX5@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU11330	ACP_syn_III,ACP_syn_III_C
CMS2_k127_2177469_2	1499967.BAYZ01000026_gene1569	9.501e-282	878.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
CMS2_k127_2177469_1	574087.Acear_1941	1.427e-316	981.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,3WB0U@53433|Halanaerobiales	186801|Clostridia	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
CMS2_k127_2177469_0	1408422.JHYF01000017_gene1871	0.0	1513.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2177469_10	1178540.BA70_16965	8.465e-67	263.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HV19@91061|Bacilli,1ZD1S@1386|Bacillus	91061|Bacilli	Q	Polyketide synthase of type I	-	-	-	ko:K13612,ko:K13613,ko:K13615	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	AMP-binding,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,NAD_binding_4,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_219261_0	1009370.ALO_00935	0.0	2708.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_219261_4	509191.AEDB02000067_gene916	8.741e-183	589.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_219261_2	1042163.BRLA_c025640	2.279e-291	943.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_219261_3	509191.AEDB02000067_gene916	6.594e-186	597.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_219261_1	1121121.KB894307_gene2066	0.0	1275.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2193539_1	240292.Ava_1611	1.254e-288	932.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_2193539_0	41431.PCC8801_3683	0.0	1353.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,3KJ4W@43988|Cyanothece	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,PilZ,Thioesterase
CMS2_k127_2207561_6	234621.RER_42950	2.689e-21	99.0	COG3693@1|root,COG3693@2|Bacteria,2GN8V@201174|Actinobacteria,4FZTD@85025|Nocardiaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Glyco_hydro_42,Glyco_hydro_cc
CMS2_k127_2207561_0	1173022.Cri9333_1189	2.266e-244	774.0	COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria,1H87F@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
CMS2_k127_2207561_9	1334046.AYTB01000020_gene617	0.0006604	49.0	2BJ8Y@1|root,32DIK@2|Bacteria,1VNCQ@1239|Firmicutes,4I0JK@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2207561_4	204669.Acid345_1027	1.175e-34	139.0	COG1595@1|root,COG1595@2|Bacteria,3Y4HK@57723|Acidobacteria,2JJAJ@204432|Acidobacteriia	204432|Acidobacteriia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_2207561_2	1296416.JACB01000063_gene2012	2.169e-103	356.0	COG0265@1|root,COG0265@2|Bacteria,4NJVK@976|Bacteroidetes,1I963@117743|Flavobacteriia,2YKKS@290174|Aquimarina	976|Bacteroidetes	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Trypsin_2
CMS2_k127_2207561_3	1317122.ATO12_04130	1.588e-92	317.0	28HG9@1|root,2Z7S5@2|Bacteria,4NF7W@976|Bacteroidetes,1I32B@117743|Flavobacteriia,2YIVX@290174|Aquimarina	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2207561_1	1191523.MROS_1193	1.952e-208	663.0	COG1574@1|root,COG1574@2|Bacteria	2|Bacteria	G	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS2_k127_2207561_5	1177179.A11A3_10766	7.144e-29	116.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1XH85@135619|Oceanospirillales	135619|Oceanospirillales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
CMS2_k127_2220567_4	706587.Desti_1108	1.087e-187	598.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2MR87@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	pcmT	-	1.3.7.9	ko:K04108	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS2_k127_2220567_11	1047013.AQSP01000137_gene558	1.717e-98	336.0	COG2866@1|root,COG2866@2|Bacteria,2NPI7@2323|unclassified Bacteria	2|Bacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.4.17.18,3.4.17.22	ko:K05996,ko:K07752	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CarboxypepD_reg,Peptidase_M14,Peptidase_M6,fn3
CMS2_k127_2220567_22	944479.JQLX01000016_gene389	0.0005195	52.0	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,42N9J@68525|delta/epsilon subdivisions,2WK7H@28221|Deltaproteobacteria,2M7IS@213113|Desulfurellales	28221|Deltaproteobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
CMS2_k127_2220567_15	768706.Desor_2653	1.32e-31	128.0	COG4231@1|root,COG4231@2|Bacteria,1VAJQ@1239|Firmicutes,24MVB@186801|Clostridia,262JW@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
CMS2_k127_2220567_10	706587.Desti_1022	1.313e-103	349.0	COG1456@1|root,COG1456@2|Bacteria,1R6BH@1224|Proteobacteria,42NKF@68525|delta/epsilon subdivisions,2WJ72@28221|Deltaproteobacteria,2MQZ6@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
CMS2_k127_2220567_18	1321778.HMPREF1982_00803	2.2e-21	99.0	COG1846@1|root,COG1846@2|Bacteria,1V9AQ@1239|Firmicutes,24GW2@186801|Clostridia	186801|Clostridia	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
CMS2_k127_2220567_5	945713.IALB_2667	1.188e-154	498.0	COG0579@1|root,COG0579@2|Bacteria	2|Bacteria	S	malate dehydrogenase (menaquinone) activity	lhgO	-	1.1.99.2	ko:K00109,ko:K15736	ko00650,map00650	-	R03534	RC00031	ko00000,ko00001,ko01000	-	-	-	DAO
CMS2_k127_2220567_0	1232410.KI421418_gene2138	0.0	1292.0	COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,42M43@68525|delta/epsilon subdivisions,2WKJD@28221|Deltaproteobacteria,43T8U@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Belongs to the aconitase IPM isomerase family	acnB	-	4.2.1.3,4.2.1.99	ko:K01682	ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173	R01324,R01325,R01900,R04425	RC00497,RC00498,RC00618,RC01153	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_2_N,Aconitase_B_N
CMS2_k127_2220567_16	1499967.BAYZ01000125_gene2598	9.166e-28	130.0	COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,Sulfatase
CMS2_k127_2220567_7	314345.SPV1_13147	7.387e-136	447.0	COG1075@1|root,COG1075@2|Bacteria,1NAEF@1224|Proteobacteria	1224|Proteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	plaB	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2220567_6	1047013.AQSP01000123_gene1546	2.383e-145	487.0	COG4953@1|root,COG4953@2|Bacteria,2NQMA@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-Binding Protein C-terminus Family	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
CMS2_k127_2220567_20	1397696.KK211189_gene1647	2.296e-11	77.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HB73@91061|Bacilli,3WFG4@539002|Bacillales incertae sedis	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K13767	ko00071,ko00362,ko01100,ko01120,ko01212,map00071,map00362,map01100,map01120,map01212	M00087	R03026,R04170,R04738,R04740,R04744,R04746	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS2_k127_2220567_14	768066.HELO_3947	1.308e-74	265.0	COG0183@1|root,COG0183@2|Bacteria,1MXYM@1224|Proteobacteria,1S0V9@1236|Gammaproteobacteria,1XN9H@135619|Oceanospirillales	135619|Oceanospirillales	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
CMS2_k127_2220567_17	909663.KI867150_gene1036	7.014e-27	115.0	COG1545@1|root,COG1545@2|Bacteria,1N4S9@1224|Proteobacteria,42U3D@68525|delta/epsilon subdivisions,2WQNA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
CMS2_k127_2220567_8	706587.Desti_2452	2.764e-126	414.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS2_k127_2220567_13	316067.Geob_0099	3.391e-92	309.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,42QAM@68525|delta/epsilon subdivisions,2WM04@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS2_k127_2220567_3	1379698.RBG1_1C00001G0509	9.465e-244	771.0	COG1042@1|root,COG1042@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
CMS2_k127_2220567_19	536232.CLM_3252	8.411e-21	106.0	COG0641@1|root,COG0641@2|Bacteria,1TT6S@1239|Firmicutes,248QW@186801|Clostridia,36FP9@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	ccpM	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
CMS2_k127_2220567_9	1121104.AQXH01000001_gene1459	1.408e-125	438.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,4NRVM@976|Bacteroidetes,1IQDC@117747|Sphingobacteriia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
CMS2_k127_2220567_2	1121930.AQXG01000001_gene1202	1.31e-315	996.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1IPZZ@117747|Sphingobacteriia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS2_k127_2220567_1	1121930.AQXG01000001_gene1203	0.0	1279.0	COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS2_k127_2220567_12	1121104.AQXH01000001_gene1411	2.252e-94	321.0	COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
CMS2_k127_2221_3	1047013.AQSP01000131_gene1812	1.919e-67	243.0	COG0641@1|root,COG0641@2|Bacteria	2|Bacteria	C	radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS2_k127_2221_4	439235.Dalk_2359	5.845e-39	149.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,433JP@68525|delta/epsilon subdivisions,2WYAX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
CMS2_k127_2221_2	439235.Dalk_2363	4.979e-77	267.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,430Q4@68525|delta/epsilon subdivisions,2WVN2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS2_k127_2221_1	880073.Calab_3682	1.167e-179	571.0	COG2301@1|root,COG3052@1|root,COG2301@2|Bacteria,COG3052@2|Bacteria,2NQDZ@2323|unclassified Bacteria	2|Bacteria	G	HpcH/HpaI aldolase/citrate lyase family	citD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0008815,GO:0009346,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016833,GO:0032991,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114	4.1.3.25,4.1.3.34	ko:K01644,ko:K01646,ko:K18292	ko00660,ko01100,ko02020,map00660,map01100,map02020	-	R00237,R00362	RC00067,RC00502,RC01118,RC01205	ko00000,ko00001,ko01000	-	-	-	ACP,HpcH_HpaI
CMS2_k127_2221_0	880073.Calab_3681	2.963e-276	856.0	COG3051@1|root,COG3051@2|Bacteria,2NP8D@2323|unclassified Bacteria	2|Bacteria	C	Citrate lyase, alpha subunit (CitF)	citF	-	2.8.3.10	ko:K01643	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	CitF
CMS2_k127_2227075_0	509191.AEDB02000067_gene921	0.0	1030.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2229744_0	1173023.KE650771_gene5201	0.0	1121.0	COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,Thioesterase,ketoacyl-synt
CMS2_k127_2230586_6	1232437.KL661958_gene2890	2.353e-102	336.0	COG1034@1|root,COG1034@2|Bacteria,1RK80@1224|Proteobacteria,43CTD@68525|delta/epsilon subdivisions,2X80Y@28221|Deltaproteobacteria,2MPQ2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4_7
CMS2_k127_2230586_2	56780.SYN_01648	0.0	1073.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MR61@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NADH ubiquinone oxidoreductase, NADH-binding	bamH	-	1.12.1.3,1.6.5.3	ko:K00124,ko:K00335,ko:K18331	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
CMS2_k127_2230586_9	706587.Desti_1917	1.419e-77	261.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,43B7N@68525|delta/epsilon subdivisions,2X6M3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3,1.6.99.3	ko:K00334,ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	2Fe-2S_thioredx
CMS2_k127_2230586_7	316067.Geob_0216	1.151e-95	320.0	COG1414@1|root,COG1908@1|root,COG1414@2|Bacteria,COG1908@2|Bacteria,1RBWB@1224|Proteobacteria,42QRJ@68525|delta/epsilon subdivisions,2WN64@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	bamF	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_2083	FlpD,HTH_5
CMS2_k127_2230586_0	767817.Desgi_1112	0.0	1673.0	COG1148@1|root,COG1233@1|root,COG1148@2|Bacteria,COG1233@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia	1239|Firmicutes	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,Pyr_redox_2
CMS2_k127_2230586_3	706587.Desti_1914	2.369e-205	644.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MR3T@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Cysteine-rich domain	bamD	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
CMS2_k127_2230586_8	706587.Desti_1913	2.109e-85	286.0	COG1142@1|root,COG1142@2|Bacteria,1RBG7@1224|Proteobacteria,42R5G@68525|delta/epsilon subdivisions,2WMV5@28221|Deltaproteobacteria,2MR63@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K19516	ko00362,ko01100,ko01120,map00362,map01100,map01120	M00541	R10961	RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	-
CMS2_k127_2230586_1	706587.Desti_1912	0.0	1191.0	COG2414@1|root,COG2414@2|Bacteria,1R5AG@1224|Proteobacteria,42NHF@68525|delta/epsilon subdivisions,2WK3Z@28221|Deltaproteobacteria,2MQUC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	bamB-1	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS2_k127_2230586_5	1379698.RBG1_1C00001G0892	4.247e-116	383.0	COG1062@1|root,COG1062@2|Bacteria	2|Bacteria	C	S-(hydroxymethyl)glutathione dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N
CMS2_k127_2230586_11	589924.Ferp_1031	1.49e-47	181.0	COG1024@1|root,arCOG00239@2157|Archaea,2Y32N@28890|Euryarchaeota,246MH@183980|Archaeoglobi	183980|Archaeoglobi	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS2_k127_2230586_12	384616.Pisl_0414	2.749e-36	143.0	COG0251@1|root,arCOG01630@2157|Archaea,2XQQW@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
CMS2_k127_2230586_4	767817.Desgi_1967	1.507e-145	470.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	bamA	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788	3.7.1.21	ko:K07539,ko:K18570	ko00332,ko00362,ko01100,ko01120,ko01130,ko01220,map00332,map00362,map01100,map01120,map01130,map01220	M00541	R05593,R05594,R10696,R10750	RC01430,RC01431,RC03237,RC03270	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS2_k127_2230586_13	582744.Msip34_2047	1.284e-33	136.0	COG4886@1|root,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	LRR_4
CMS2_k127_2230586_10	1408437.JNJN01000001_gene1721	5.23e-55	198.0	COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,24HVV@186801|Clostridia,25W60@186806|Eubacteriaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
CMS2_k127_2230892_4	243231.GSU2107	5.015e-168	555.0	COG0286@1|root,COG1002@1|root,COG0286@2|Bacteria,COG1002@2|Bacteria,1NZDR@1224|Proteobacteria,42NKT@68525|delta/epsilon subdivisions,2WM7B@28221|Deltaproteobacteria,43U85@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	N-6 DNA Methylase	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I,N6_Mtase
CMS2_k127_2230892_0	243231.GSU2108	0.0	1304.0	COG4928@1|root,COG4928@2|Bacteria	2|Bacteria	G	KAP family P-loop domain	-	-	-	-	-	-	-	-	-	-	-	-	KAP_NTPase
CMS2_k127_2230892_27	243231.GSU2110	3.777e-66	235.0	28P43@1|root,2ZBZD@2|Bacteria,1NIC2@1224|Proteobacteria,433CD@68525|delta/epsilon subdivisions,2WXTU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative inner membrane protein (DUF1819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1819
CMS2_k127_2230892_36	391612.CY0110_17352	5.288e-39	149.0	2APBK@1|root,31EDU@2|Bacteria,1G74D@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2230892_43	237368.SCABRO_03380	8.439e-24	103.0	2CCMX@1|root,330YA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2230892_39	747365.Thena_1458	3.05e-32	139.0	COG5464@1|root,COG5464@2|Bacteria,1UGME@1239|Firmicutes,248B2@186801|Clostridia,42FDJ@68295|Thermoanaerobacterales	186801|Clostridia	S	Putative transposase, YhgA-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
CMS2_k127_2230892_25	273526.SMDB11_2748	6.636e-81	288.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,1RMQ0@1236|Gammaproteobacteria,401RE@613|Serratia	1236|Gammaproteobacteria	K	Transcriptional regulator	-	-	2.6.1.103	ko:K05825,ko:K16423	ko00261,ko00300,ko01055,ko01100,ko01130,ko01210,map00261,map00300,map01055,map01100,map01130,map01210	-	R01939,R06626,R06634	RC00006,RC01104	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2,GntR
CMS2_k127_2230892_32	1033732.CAHI01000030_gene1057	9.988e-43	166.0	COG0731@1|root,COG0731@2|Bacteria,4NJEM@976|Bacteroidetes,2FMWY@200643|Bacteroidia,22UDB@171550|Rikenellaceae	976|Bacteroidetes	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
CMS2_k127_2230892_51	1220534.B655_1048	4.313e-11	74.0	arCOG02499@1|root,arCOG02501@1|root,arCOG02499@2157|Archaea,arCOG02501@2157|Archaea,2Y0FJ@28890|Euryarchaeota	28890|Euryarchaeota	O	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	NosD
CMS2_k127_2230892_57	565653.EGBG_00268	0.0002116	55.0	COG4447@1|root,COG4447@2|Bacteria,1TRSI@1239|Firmicutes,4IQ74@91061|Bacilli,4B6QP@81852|Enterococcaceae	91061|Bacilli	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2230892_15	439235.Dalk_0237	2.997e-107	384.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_2230892_59	945713.IALB_0674	0.0005353	51.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128
CMS2_k127_2230892_31	7668.SPU_012060-tr	3.184e-44	177.0	COG0666@1|root,KOG0504@2759|Eukaryota,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3BGGV@33208|Metazoa,3CT1S@33213|Bilateria	33208|Metazoa	M	ankyrin 3, node of Ranvier (ankyrin G)	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,ZU5
CMS2_k127_2230892_44	1476973.JMMB01000007_gene2033	1.547e-22	108.0	COG1131@1|root,COG1131@2|Bacteria,1TPUP@1239|Firmicutes,249FR@186801|Clostridia,25SMQ@186804|Peptostreptococcaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_2230892_48	1132442.KB889752_gene3015	8.224e-19	92.0	COG1725@1|root,COG1725@2|Bacteria,1VFD0@1239|Firmicutes,4HNIT@91061|Bacilli,1ZGQV@1386|Bacillus	91061|Bacilli	K	GntR family transcriptional regulator	ytrA	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS2_k127_2230892_13	880073.Calab_1599	4.692e-123	419.0	COG2864@1|root,COG2864@2|Bacteria,2NNNM@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b subunit of formate dehydrogenase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
CMS2_k127_2230892_6	335543.Sfum_2102	1.359e-161	521.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,43BJP@68525|delta/epsilon subdivisions,2WJWZ@28221|Deltaproteobacteria,2MQSJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2,4.3.1.1	ko:K01679,ko:K01744	ko00020,ko00250,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00250,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R00490,R01082	RC00316,RC00443,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
CMS2_k127_2230892_41	373903.Hore_22490	9.215e-26	107.0	COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,3WC7H@53433|Halanaerobiales	186801|Clostridia	C	PFAM Rubredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
CMS2_k127_2230892_29	596151.DesfrDRAFT_3521	3.012e-61	212.0	COG2033@1|root,COG2033@2|Bacteria,1RHE0@1224|Proteobacteria,42SB9@68525|delta/epsilon subdivisions,2WP2D@28221|Deltaproteobacteria,2MBEZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Desulfoferrodoxin ferrous iron-binding region	dfx	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
CMS2_k127_2230892_47	909663.KI867150_gene2084	1.625e-19	94.0	COG1633@1|root,COG1633@2|Bacteria,1RGYD@1224|Proteobacteria,42T5E@68525|delta/epsilon subdivisions,2WPKD@28221|Deltaproteobacteria,2MQPQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_2230892_5	386456.JQKN01000008_gene1445	3.427e-162	520.0	COG0426@1|root,arCOG00509@2157|Archaea,2XSUD@28890|Euryarchaeota,23PC4@183925|Methanobacteria	183925|Methanobacteria	C	PFAM Flavodoxin nitric oxide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_2230892_45	28072.Nos7524_5015	4.112e-20	91.0	COG1773@1|root,COG1773@2|Bacteria	2|Bacteria	C	rubredoxin	rub	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
CMS2_k127_2230892_34	1319815.HMPREF0202_02184	5.751e-40	153.0	COG0735@1|root,COG0735@2|Bacteria,37ADT@32066|Fusobacteria	32066|Fusobacteria	P	Belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS2_k127_2230892_33	1047013.AQSP01000144_gene883	4.57e-41	164.0	COG3203@1|root,COG3203@2|Bacteria,2NQU9@2323|unclassified Bacteria	2|Bacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Porin_4
CMS2_k127_2230892_9	929562.Emtol_0970	1.249e-145	477.0	COG0624@1|root,COG0624@2|Bacteria,4NEA7@976|Bacteroidetes,47JSS@768503|Cytophagia	976|Bacteroidetes	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS2_k127_2230892_22	891968.Anamo_0048	1.455e-83	287.0	COG0329@1|root,COG0329@2|Bacteria,3TAA2@508458|Synergistetes	508458|Synergistetes	H	Belongs to the DapA family	-	-	4.1.3.16	ko:K18123	ko00330,ko00630,ko01100,map00330,map00630,map01100	-	R00470,R00471	RC00307,RC00308	ko00000,ko00001,ko01000	-	-	-	DHDPS
CMS2_k127_2230892_40	1304885.AUEY01000008_gene2085	3.64e-26	114.0	COG2905@1|root,COG4670@1|root,COG2905@2|Bacteria,COG4670@2|Bacteria,1QTTR@1224|Proteobacteria,42TN6@68525|delta/epsilon subdivisions,2WPMT@28221|Deltaproteobacteria,2MKDM@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS2_k127_2230892_1	1047013.AQSP01000126_gene2741	4.695e-284	889.0	COG0339@1|root,COG0339@2|Bacteria,2NP9Q@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M3	prlC	-	3.4.15.5,3.4.24.70	ko:K01284,ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
CMS2_k127_2230892_21	1209989.TepiRe1_1685	1.26e-85	303.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,42ER0@68295|Thermoanaerobacterales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
CMS2_k127_2230892_42	1187851.A33M_4309	2.553e-24	113.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2TRZ5@28211|Alphaproteobacteria,3FD20@34008|Rhodovulum	28211|Alphaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
CMS2_k127_2230892_30	1265845.PWEIH_05524	1.737e-50	187.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,26K4H@186820|Listeriaceae	91061|Bacilli	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
CMS2_k127_2230892_49	880073.Calab_0016	6.294e-15	85.0	COG2815@1|root,COG2815@2|Bacteria,2NPV8@2323|unclassified Bacteria	2|Bacteria	S	PASTA	spk1	-	2.7.11.1,3.4.16.4,6.3.2.4	ko:K01921,ko:K03587,ko:K08884,ko:K12132	ko00473,ko00550,ko01100,ko01501,ko01502,map00473,map00550,map01100,map01501,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01001,ko01011,ko03036	-	-	-	PASTA,TIR_2
CMS2_k127_2230892_19	635013.TherJR_2333	1.896e-88	306.0	COG3434@1|root,COG3434@2|Bacteria,1TPWC@1239|Firmicutes,248M1@186801|Clostridia,26466@186807|Peptococcaceae	186801|Clostridia	T	signal transduction protein containing EAL and modified HD-GYP	-	-	-	-	-	-	-	-	-	-	-	-	EAL,HDOD
CMS2_k127_2230892_55	999411.HMPREF1092_03286	7.556e-06	53.0	COG1396@1|root,COG1396@2|Bacteria,1VEU8@1239|Firmicutes,24QN0@186801|Clostridia,36N7U@31979|Clostridiaceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
CMS2_k127_2230892_7	1047013.AQSP01000085_gene2000	8.369e-157	522.0	COG4775@1|root,COG4775@2|Bacteria,2NNNW@2323|unclassified Bacteria	2|Bacteria	M	Surface antigen	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
CMS2_k127_2230892_23	909663.KI867150_gene1439	1.643e-81	278.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2MRKV@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM response regulator receiver	-	-	-	ko:K07657,ko:K07663	ko02020,map02020	M00434,M00449	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_2230892_8	909663.KI867150_gene1440	7.61e-147	485.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,2MQCA@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Signal transduction histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
CMS2_k127_2230892_35	522772.Dacet_0028	4.94e-39	151.0	COG0242@1|root,COG0242@2|Bacteria,2GFNS@200930|Deferribacteres	200930|Deferribacteres	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
CMS2_k127_2230892_26	204536.SULAZ_0409	3.468e-67	240.0	COG0223@1|root,COG0223@2|Bacteria,2G3PD@200783|Aquificae	200783|Aquificae	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
CMS2_k127_2230892_38	639282.DEFDS_1996	4.17e-35	150.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GEZP@200930|Deferribacteres	200930|Deferribacteres	JK	16S rRNA methyltransferase RsmB/F	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
CMS2_k127_2230892_11	1085623.GNIT_3348	6.64e-129	442.0	COG0642@1|root,COG0715@1|root,COG0642@2|Bacteria,COG0715@2|Bacteria,1NXDJ@1224|Proteobacteria,1RWXE@1236|Gammaproteobacteria,469DC@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
CMS2_k127_2230892_16	439235.Dalk_0237	2.256e-94	329.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_2230892_20	439235.Dalk_0237	9.241e-88	329.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_2230892_24	1191523.MROS_2005	2.072e-81	309.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2230892_46	1242864.D187_007304	6.817e-20	107.0	COG2706@1|root,COG2706@2|Bacteria,1PG0A@1224|Proteobacteria,43349@68525|delta/epsilon subdivisions,2WYGB@28221|Deltaproteobacteria,2Z2UF@29|Myxococcales	28221|Deltaproteobacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS2_k127_2230892_2	243231.GSU0371	1.408e-275	871.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,43T5A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Protein of unknown function (DUF3417)	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
CMS2_k127_2230892_54	272559.BF9343_0044	2.731e-06	59.0	COG3391@1|root,COG3391@2|Bacteria,4P2J2@976|Bacteroidetes,2FP5A@200643|Bacteroidia,4APY7@815|Bacteroidaceae	976|Bacteroidetes	S	6-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128
CMS2_k127_2230892_53	1047013.AQSP01000142_gene123	1.634e-06	60.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2230892_28	997350.HMPREF9129_1763	1.137e-62	233.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,22G27@1570339|Peptoniphilaceae	186801|Clostridia	C	Six-Cys-in-45 modification radical SAM protein	scfB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS2_k127_2230892_18	1191523.MROS_0687	5.681e-89	319.0	COG0457@1|root,COG0642@1|root,COG0457@2|Bacteria,COG2205@2|Bacteria	1191523.MROS_0687|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2230892_14	909663.KI867150_gene698	3.472e-121	404.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MRFN@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_2230892_3	1237149.C900_05793	1.785e-253	816.0	COG1680@1|root,COG4615@1|root,COG1680@2|Bacteria,COG4615@2|Bacteria,4NJ17@976|Bacteroidetes	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,Beta-lactamase
CMS2_k127_2230892_12	1444711.CCJF01000005_gene546	2.814e-126	449.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta,SBBP
CMS2_k127_2230892_50	1380390.JIAT01000014_gene6288	6.445e-12	80.0	COG0028@1|root,COG0515@1|root,COG1470@1|root,COG2133@1|root,COG3291@1|root,COG0028@2|Bacteria,COG0515@2|Bacteria,COG1470@2|Bacteria,COG2133@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	Calx-beta,DUF4347,GSDH,Laminin_G_3,PA14,PKD
CMS2_k127_2230892_17	439235.Dalk_0237	8.533e-91	338.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_2230892_10	1444711.CCJF01000005_gene546	1.164e-144	488.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta,SBBP
CMS2_k127_2231558_1	429009.Adeg_0798	7.306e-18	91.0	COG2253@1|root,COG2253@2|Bacteria,1W4PF@1239|Firmicutes,256FN@186801|Clostridia	186801|Clostridia	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS2_k127_2231558_0	1123508.JH636447_gene7971	6.093e-29	123.0	COG0596@1|root,COG0596@2|Bacteria,2J4WT@203682|Planctomycetes	203682|Planctomycetes	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2241252_9	573061.Clocel_0851	6.86e-12	72.0	COG1409@1|root,COG1409@2|Bacteria,1V7BW@1239|Firmicutes,24PK5@186801|Clostridia,36TE9@31979|Clostridiaceae	186801|Clostridia	V	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_2241252_3	1173024.KI912149_gene5751	2.678e-49	181.0	COG1670@1|root,COG1670@2|Bacteria,1GCUW@1117|Cyanobacteria,1JJZD@1189|Stigonemataceae	1117|Cyanobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
CMS2_k127_2241252_4	443254.Marpi_0553	3.762e-45	166.0	COG0432@1|root,COG0432@2|Bacteria,2GD2P@200918|Thermotogae	200918|Thermotogae	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CMS2_k127_2241252_0	1047013.AQSP01000101_gene609	6.119e-255	807.0	COG4447@1|root,COG4447@2|Bacteria,2NQN9@2323|unclassified Bacteria	2|Bacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	BNR,BNR_6,Sortilin-Vps10
CMS2_k127_2241252_5	1304885.AUEY01000040_gene1615	3.385e-30	134.0	COG0745@1|root,COG0745@2|Bacteria,1RIGT@1224|Proteobacteria,42SWP@68525|delta/epsilon subdivisions,2WPJ3@28221|Deltaproteobacteria,2MK4B@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,Response_reg
CMS2_k127_2241252_7	866546.EPY49848	1.635e-14	82.0	KOG0615@1|root,KOG0615@2759|Eukaryota,38DUI@33154|Opisthokonta,3NVJ5@4751|Fungi,3QN24@4890|Ascomycota,3MDND@451866|Taphrinomycotina	4751|Fungi	D	Belongs to the protein kinase superfamily	RAD53	GO:0000003,GO:0000075,GO:0000076,GO:0000077,GO:0000166,GO:0000278,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0004672,GO:0004674,GO:0004712,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006281,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007049,GO:0007093,GO:0007154,GO:0007165,GO:0007346,GO:0008104,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009141,GO:0009142,GO:0009200,GO:0009202,GO:0009889,GO:0009892,GO:0009987,GO:0010389,GO:0010556,GO:0010563,GO:0010564,GO:0010941,GO:0010948,GO:0010972,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018105,GO:0018107,GO:0018130,GO:0018193,GO:0018209,GO:0018210,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0022402,GO:0022414,GO:0023052,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031570,GO:0031573,GO:0032386,GO:0032387,GO:0032507,GO:0032553,GO:0032555,GO:0032559,GO:0032879,GO:0032880,GO:0033036,GO:0033157,GO:0033262,GO:0033313,GO:0033314,GO:0033315,GO:0033365,GO:0033554,GO:0034504,GO:0034613,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0042325,GO:0042326,GO:0042770,GO:0042981,GO:0043067,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044773,GO:0044774,GO:0044778,GO:0044818,GO:0045185,GO:0045786,GO:0045930,GO:0045936,GO:0046483,GO:0046822,GO:0046823,GO:0046825,GO:0046826,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051051,GO:0051052,GO:0051171,GO:0051174,GO:0051179,GO:0051223,GO:0051224,GO:0051235,GO:0051321,GO:0051445,GO:0051447,GO:0051457,GO:0051641,GO:0051651,GO:0051716,GO:0051726,GO:0055086,GO:0060255,GO:0060341,GO:0065007,GO:0065008,GO:0070201,GO:0070727,GO:0071704,GO:0072595,GO:0080090,GO:0090087,GO:0090304,GO:0090317,GO:0090329,GO:0090407,GO:0097159,GO:0097367,GO:0110030,GO:0110031,GO:0140096,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1901993,GO:1901994,GO:1902749,GO:1902750,GO:1903046,GO:1903047,GO:1903463,GO:1903466,GO:1903827,GO:1903828,GO:1904950,GO:1990837,GO:2000112,GO:2000241,GO:2000242	2.7.11.1	ko:K02831,ko:K06641	ko04110,ko04111,ko04113,ko04115,ko04218,ko05166,map04110,map04111,map04113,map04115,map04218,map05166	M00691	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko03400	-	-	-	FHA,Pkinase
CMS2_k127_2241252_8	1304885.AUEY01000040_gene1615	9.099e-13	74.0	COG0745@1|root,COG0745@2|Bacteria,1RIGT@1224|Proteobacteria,42SWP@68525|delta/epsilon subdivisions,2WPJ3@28221|Deltaproteobacteria,2MK4B@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,Response_reg
CMS2_k127_2241252_1	1047013.AQSP01000099_gene1499	5.731e-173	556.0	COG0112@1|root,COG0112@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	-	-	2.1.2.1,2.1.2.10,2.2.1.8	ko:K00600,ko:K00605,ko:K18847	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R01221,R02300,R04125,R09099	RC00022,RC00069,RC00112,RC00183,RC01583,RC02834,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C,SHMT
CMS2_k127_2241252_2	1121904.ARBP01000014_gene141	1.383e-77	268.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Peptidase_C14,Pkinase,WD40
CMS2_k127_2246641_1	1047013.AQSP01000131_gene1841	3.699e-111	393.0	COG1629@1|root,COG4773@1|root,COG4771@2|Bacteria,COG4773@2|Bacteria,2NP6Z@2323|unclassified Bacteria	2|Bacteria	P	COGs COG1629 Outer membrane receptor protein mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
CMS2_k127_2246641_0	1127673.GLIP_3752	8.023e-147	480.0	COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,1RQJY@1236|Gammaproteobacteria,465VV@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
CMS2_k127_2246641_2	865861.AZSU01000003_gene2036	1.85e-47	196.0	COG1474@1|root,COG1474@2|Bacteria	2|Bacteria	LO	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,CHAT,TPR_12,TniB
CMS2_k127_2252907_2	1034807.FBFL15_2073	5.403e-93	311.0	COG5464@1|root,COG5464@2|Bacteria,4NJT2@976|Bacteroidetes,1IDMC@117743|Flavobacteriia,2NYR8@237|Flavobacterium	976|Bacteroidetes	S	to proteins from other organisms	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_2252907_1	1265503.KB905162_gene3593	1.174e-138	467.0	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria,2Q7GY@267889|Colwelliaceae	1236|Gammaproteobacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_2252907_0	697284.ERIC2_c18040	1.041e-169	556.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2263429_2	1254432.SCE1572_33155	1.145e-74	259.0	COG0667@1|root,COG0667@2|Bacteria,1NWQE@1224|Proteobacteria,42ZW2@68525|delta/epsilon subdivisions,2WVDI@28221|Deltaproteobacteria,2YVXI@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,HEAT_2
CMS2_k127_2263429_3	909663.KI867150_gene2380	1.154e-70	250.0	COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,42U8Z@68525|delta/epsilon subdivisions,2WQQT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
CMS2_k127_2263429_6	1137799.GZ78_10685	3.47e-32	137.0	COG4667@1|root,COG4667@2|Bacteria,1PV7M@1224|Proteobacteria,1RRPR@1236|Gammaproteobacteria,1XM1D@135619|Oceanospirillales	135619|Oceanospirillales	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
CMS2_k127_2263429_11	927658.AJUM01000037_gene2446	5.426e-05	53.0	COG3637@1|root,COG3637@2|Bacteria,4NR9K@976|Bacteroidetes,2G1FZ@200643|Bacteroidia,3XKWZ@558415|Marinilabiliaceae	976|Bacteroidetes	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,OMP_b-brl_2
CMS2_k127_2263429_5	945713.IALB_1857	1.249e-54	209.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbU	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,GAF_3,SpoIIE
CMS2_k127_2263429_8	869213.JCM21142_83222	1.437e-18	99.0	COG5000@1|root,COG5000@2|Bacteria,4NEWF@976|Bacteroidetes	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
CMS2_k127_2263429_0	1121920.AUAU01000009_gene1860	1.466e-152	492.0	COG5557@1|root,COG5557@2|Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
CMS2_k127_2263429_1	1121920.AUAU01000009_gene1859	5.777e-131	426.0	COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	-
CMS2_k127_2263429_4	1232410.KI421424_gene1760	4.931e-61	215.0	COG2010@1|root,COG2010@2|Bacteria,1QYFZ@1224|Proteobacteria,43CC3@68525|delta/epsilon subdivisions,2WQTQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2263429_9	1121918.ARWE01000001_gene70	3.608e-15	88.0	COG3005@1|root,COG3005@2|Bacteria,1RJ3G@1224|Proteobacteria,42ST3@68525|delta/epsilon subdivisions,2WP9Q@28221|Deltaproteobacteria,43TP2@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT,Cytochrome_C7
CMS2_k127_2263429_10	635013.TherJR_2595	2.901e-05	56.0	COG3303@1|root,COG3303@2|Bacteria,1VQ4R@1239|Firmicutes,24VCY@186801|Clostridia,265U5@186807|Peptococcaceae	186801|Clostridia	P	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552,Cytochrome_C554
CMS2_k127_2263474_1	1196322.A370_02909	7.312e-12	78.0	COG4249@1|root,COG4249@2|Bacteria,1UA57@1239|Firmicutes,24CYB@186801|Clostridia,36PAI@31979|Clostridiaceae	186801|Clostridia	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
CMS2_k127_2263474_0	485918.Cpin_4187	7.657e-168	553.0	COG3409@1|root,COG3409@2|Bacteria,4NQ9D@976|Bacteroidetes	976|Bacteroidetes	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_22648_0	1124780.ANNU01000002_gene1509	7.642e-156	527.0	COG0308@1|root,COG0308@2|Bacteria,4NF3R@976|Bacteroidetes,47N7W@768503|Cytophagia	976|Bacteroidetes	E	Peptidase family M1 domain	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_4,ABC2_membrane_5,Peptidase_M1
CMS2_k127_22648_1	760192.Halhy_3820	3.567e-112	370.0	COG1131@1|root,COG1131@2|Bacteria,4NFWM@976|Bacteroidetes,1IQUT@117747|Sphingobacteriia	976|Bacteroidetes	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS2_k127_22648_9	290315.Clim_1380	2.64e-19	94.0	COG1525@1|root,COG1525@2|Bacteria	2|Bacteria	L	nuclease	-	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	SNase
CMS2_k127_22648_2	479434.Sthe_2780	1.946e-103	362.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2G7MH@200795|Chloroflexi,27XJR@189775|Thermomicrobia	189775|Thermomicrobia	EU	Peptidase S9, prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS2_k127_22648_8	1231392.OCGS_2006	1.45e-32	140.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane protein (homolog of Drosophila rhomboid)	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS2_k127_22648_3	999419.HMPREF1077_01415	2.729e-100	340.0	COG0454@1|root,COG0456@2|Bacteria,4NFWE@976|Bacteroidetes,2FNG4@200643|Bacteroidia,22WRZ@171551|Porphyromonadaceae	976|Bacteroidetes	K	Psort location Cytoplasmic, score 8.96	yghO	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_22648_7	316274.Haur_4656	6.475e-41	171.0	COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,2GBIX@200795|Chloroflexi,3759D@32061|Chloroflexia	32061|Chloroflexia	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4
CMS2_k127_22648_6	177437.HRM2_05470	8.956e-43	166.0	arCOG05125@1|root,2ZF8I@2|Bacteria,1N0ZV@1224|Proteobacteria,42UP9@68525|delta/epsilon subdivisions,2WR45@28221|Deltaproteobacteria,2MMHC@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Family of unknown function (DUF5328)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5328
CMS2_k127_22648_5	926692.AZYG01000070_gene1687	1.931e-81	296.0	2DBGK@1|root,2Z952@2|Bacteria,1UY0R@1239|Firmicutes,249RE@186801|Clostridia,3WAY8@53433|Halanaerobiales	186801|Clostridia	S	CRISPR-associated protein TM1802 (cas_TM1802)	-	-	-	ko:K19114	-	-	-	-	ko00000,ko02048	-	-	-	Cas_TM1802
CMS2_k127_22648_4	402880.MmarC5_0770	1.024e-88	300.0	COG3649@1|root,arCOG02757@2157|Archaea,2XTU4@28890|Euryarchaeota,23R2B@183939|Methanococci	183939|Methanococci	V	PFAM CRISPR-associated protein TM1801	-	-	-	ko:K19115	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Cas7
CMS2_k127_2265154_1	118005.AWNK01000004_gene1064	0.0	1342.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2265154_4	711393.AYRX01000103_gene5911	2.322e-122	447.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_2265154_3	1047013.AQSP01000134_gene1348	4.906e-136	462.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_2265154_0	98439.AJLL01000095_gene4183	0.0	1414.0	COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2265154_2	755731.Clo1100_1301	0.0	1261.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,Thioesterase,ketoacyl-synt
CMS2_k127_2292590_0	1254432.SCE1572_29990	1.226e-05	58.0	COG0739@1|root,COG2373@1|root,COG0739@2|Bacteria,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,Peptidase_M23,PhageMin_Tail,SLT_2
CMS2_k127_2296770_0	266748.HY04_10545	0.0001348	45.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,4NDVV@976|Bacteroidetes,1HWME@117743|Flavobacteriia,3ZNWS@59732|Chryseobacterium	976|Bacteroidetes	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
CMS2_k127_2296770_1	760192.Halhy_4061	0.000686	44.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,1IW4Z@117747|Sphingobacteriia	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_2299626_8	324057.Pjdr2_6119	5.282e-63	231.0	COG1680@1|root,COG1680@2|Bacteria,1UZUZ@1239|Firmicutes,4IPQ5@91061|Bacilli,2766V@186822|Paenibacillaceae	91061|Bacilli	V	Beta-lactamase	pbpE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
CMS2_k127_2299626_2	3067.XP_002948919.1	3.682e-126	409.0	COG0190@1|root,KOG0089@2759|Eukaryota,37K6Z@33090|Viridiplantae,34H22@3041|Chlorophyta	3041|Chlorophyta	H	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
CMS2_k127_2299626_10	395961.Cyan7425_5195	9.577e-47	178.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS2_k127_2299626_16	671143.DAMO_0884	3.712e-25	118.0	COG2887@1|root,COG2887@2|Bacteria,2NQTZ@2323|unclassified Bacteria	2|Bacteria	L	PD-(D/E)XK nuclease superfamily	-	-	3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1
CMS2_k127_2299626_18	610130.Closa_3063	2.222e-09	69.0	COG2176@1|root,COG2176@2|Bacteria,1TRS5@1239|Firmicutes,24ER5@186801|Clostridia,222FJ@1506553|Lachnoclostridium	186801|Clostridia	L	DNA polymerase family B, exonuclease domain	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	BRCT,RNase_T,zf-C4_Topoisom
CMS2_k127_2299626_11	880071.Fleli_0205	3.132e-43	165.0	COG1739@1|root,COG1739@2|Bacteria,4NF0D@976|Bacteroidetes,47P9D@768503|Cytophagia	976|Bacteroidetes	S	PFAM Uncharacterised protein family UPF0029, Impact, N-terminal	yigZ	-	-	-	-	-	-	-	-	-	-	-	UPF0029
CMS2_k127_2299626_1	1167006.UWK_00694	2.209e-128	437.0	COG2204@1|root,COG5000@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg,dCache_2
CMS2_k127_2299626_9	926569.ANT_28850	1.074e-49	181.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	ycaO	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	OsmC,YcaO
CMS2_k127_2299626_17	865861.AZSU01000002_gene2550	1.792e-14	78.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V0EJ@1239|Firmicutes,249UV@186801|Clostridia,36JEQ@31979|Clostridiaceae	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
CMS2_k127_2299626_20	1280001.BAOA01000097_gene4422	1.15e-06	55.0	COG2169@1|root,COG2169@2|Bacteria,1R4BQ@1224|Proteobacteria,1RTAM@1236|Gammaproteobacteria,1XV4B@135623|Vibrionales	135623|Vibrionales	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC
CMS2_k127_2299626_6	237368.SCABRO_03097	1.275e-74	270.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_16,TPR_8
CMS2_k127_2299626_12	639282.DEFDS_1443	3.699e-42	159.0	COG2905@1|root,COG2905@2|Bacteria,2GGGX@200930|Deferribacteres	200930|Deferribacteres	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS2_k127_2299626_5	472759.Nhal_0828	1.489e-77	274.0	COG0515@1|root,COG0515@2|Bacteria,1QXK0@1224|Proteobacteria,1T3DE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	Pkinase,TIR_2
CMS2_k127_2299626_4	573370.DMR_20580	4.535e-78	274.0	COG1488@1|root,COG1488@2|Bacteria,1R5W0@1224|Proteobacteria,42NQQ@68525|delta/epsilon subdivisions,2WPZE@28221|Deltaproteobacteria,2M7T2@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	QRPTase_C,QRPTase_N
CMS2_k127_2299626_15	5759.rna_EHI_146360-1	1.526e-31	135.0	299NX@1|root,2RGR2@2759|Eukaryota,3XGA8@554915|Amoebozoa	554915|Amoebozoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2299626_19	345341.KUTG_04140	4.119e-09	58.0	2DTR4@1|root,33MCB@2|Bacteria,2HAJT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2299626_0	1047013.AQSP01000123_gene1542	9.125e-165	530.0	COG2204@1|root,COG2204@2|Bacteria,2NP3X@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_2299626_13	1123371.ATXH01000007_gene513	8.732e-35	136.0	COG4634@1|root,COG4634@2|Bacteria,2GIM6@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2299626_14	118161.KB235922_gene3131	9.343e-33	128.0	COG2442@1|root,COG2442@2|Bacteria,1G87F@1117|Cyanobacteria	1117|Cyanobacteria	S	COGs COG2442 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
CMS2_k127_2299626_3	1191523.MROS_2212	1.817e-97	335.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_2299626_7	1173027.Mic7113_0883	2.837e-63	226.0	COG3292@1|root,COG3829@1|root,COG3920@1|root,COG3292@2|Bacteria,COG3829@2|Bacteria,COG3920@2|Bacteria,1GCAC@1117|Cyanobacteria,1HEG6@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_2343663_0	1042163.BRLA_c020400	0.0	1633.0	COG0604@1|root,COG2227@1|root,COG3321@1|root,COG4221@1|root,COG0604@2|Bacteria,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VS6K@1239|Firmicutes,4HTSI@91061|Bacilli,26W70@186822|Paenibacillaceae	91061|Bacilli	Q	Beta-ketoacyl synthase, C-terminal domain	-	-	-	ko:K13612	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	ADH_N,ADH_zinc_N,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,ketoacyl-synt
CMS2_k127_2361327_2	616991.JPOO01000001_gene3753	2.448e-42	155.0	COG0644@1|root,COG0644@2|Bacteria,4NEI6@976|Bacteroidetes,1HYZB@117743|Flavobacteriia	976|Bacteroidetes	C	pyridine nucleotide-disulfide oxidoreductase	fixC	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
CMS2_k127_2361327_1	391598.FBBAL38_08789	3.693e-53	188.0	COG2963@1|root,COG2963@2|Bacteria,4NQ94@976|Bacteroidetes,1I549@117743|Flavobacteriia	976|Bacteroidetes	L	Pfam Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
CMS2_k127_2361327_0	391598.FBBAL38_08794	2.912e-178	563.0	COG2801@1|root,COG2801@2|Bacteria,4NJ32@976|Bacteroidetes,1HZH2@117743|Flavobacteriia	976|Bacteroidetes	L	Pfam Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
CMS2_k127_2361327_3	616991.JPOO01000003_gene1318	1.693e-35	135.0	COG0385@1|root,COG0385@2|Bacteria,4NEIM@976|Bacteroidetes,1HY0F@117743|Flavobacteriia,23G6S@178469|Arenibacter	976|Bacteroidetes	S	SBF-like CPA transporter family (DUF4137)	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
CMS2_k127_2370673_6	1183438.GKIL_3245	5.982e-101	366.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G1QI@1117|Cyanobacteria	1117|Cyanobacteria	F	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,Pentapeptide,TPR_10,TPR_12,TPR_7,TPR_8
CMS2_k127_2370673_26	163908.KB235896_gene2617	0.0009181	45.0	COG2886@1|root,COG2886@2|Bacteria,1GEZP@1117|Cyanobacteria,1HQA8@1161|Nostocales	1117|Cyanobacteria	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
CMS2_k127_2370673_20	195522.BD01_2072	2.242e-32	131.0	COG2405@1|root,arCOG00717@2157|Archaea,2Y0GG@28890|Euryarchaeota,2448Z@183968|Thermococci	183968|Thermococci	V	Domain of unknown function (DUF3368)	-	-	-	ko:K07066	-	-	-	-	ko00000	-	-	-	DUF3368
CMS2_k127_2370673_18	269797.Mbar_A2759	3.755e-43	171.0	COG0265@1|root,arCOG02833@2157|Archaea	2157|Archaea	O	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Trypsin_2
CMS2_k127_2370673_3	933262.AXAM01000014_gene229	1.207e-126	419.0	COG1373@1|root,COG1373@2|Bacteria,1MWDX@1224|Proteobacteria	1224|Proteobacteria	S	ATPase (AAA superfamily)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_2370673_16	313606.M23134_00282	1.341e-53	209.0	COG4995@1|root,COG4995@2|Bacteria,4NZ2B@976|Bacteroidetes,47X3B@768503|Cytophagia	976|Bacteroidetes	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
CMS2_k127_2370673_12	306281.AJLK01000173_gene5120	5.568e-61	220.0	COG1672@1|root,COG1672@2|Bacteria,1GCFZ@1117|Cyanobacteria,1JK9S@1189|Stigonemataceae	1117|Cyanobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
CMS2_k127_2370673_13	309807.SRU_0278	1.371e-58	214.0	2EDGC@1|root,337CJ@2|Bacteria,4PEQD@976|Bacteroidetes,1FJFE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2370673_11	1090319.KE386571_gene1992	1.432e-73	261.0	COG0438@1|root,COG0438@2|Bacteria,1P4MV@1224|Proteobacteria,2UWI6@28211|Alphaproteobacteria,2K8HV@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2370673_1	929556.Solca_0522	5.075e-177	567.0	COG1032@1|root,COG1032@2|Bacteria,4PHMM@976|Bacteroidetes,1IWI2@117747|Sphingobacteriia	976|Bacteroidetes	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2370673_14	1027292.HMPREF9372_0687	1.103e-55	220.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,26D8E@186818|Planococcaceae	91061|Bacilli	KLT	serine threonine protein kinase	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_2370673_25	909663.KI867150_gene1223	5.188e-06	57.0	COG2770@1|root,COG2770@2|Bacteria,1NDB2@1224|Proteobacteria,42WRP@68525|delta/epsilon subdivisions,2WSBD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP
CMS2_k127_2370673_15	929556.Solca_1355	7.031e-54	191.0	COG0662@1|root,COG0662@2|Bacteria,4NQIP@976|Bacteroidetes,1IZZH@117747|Sphingobacteriia	976|Bacteroidetes	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS2_k127_2370673_9	1177154.Y5S_00222	9.389e-79	278.0	COG4783@1|root,COG4783@2|Bacteria,1QV70@1224|Proteobacteria,1RQJV@1236|Gammaproteobacteria,1XME4@135619|Oceanospirillales	135619|Oceanospirillales	S	Zn-dependent protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CMS2_k127_2370673_4	316067.Geob_3646	2.902e-124	413.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,42PMH@68525|delta/epsilon subdivisions,2WKZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07641,ko:K14980	ko02020,map02020	M00449,M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,dCache_3
CMS2_k127_2370673_10	1304885.AUEY01000011_gene1773	9.15e-76	261.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,42QQJ@68525|delta/epsilon subdivisions,2WMUM@28221|Deltaproteobacteria,2MMQ5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483,ko:K07663	ko02020,map02020	M00449	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_2370673_23	983920.Y88_1679	1.902e-12	79.0	COG1538@1|root,COG1538@2|Bacteria,1R5QE@1224|Proteobacteria,2U1J8@28211|Alphaproteobacteria,2K2G1@204457|Sphingomonadales	204457|Sphingomonadales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_2370673_19	159087.Daro_2253	1.093e-39	164.0	COG0845@1|root,COG0845@2|Bacteria,1MX8W@1224|Proteobacteria,2VJNH@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
CMS2_k127_2370673_0	314254.OA2633_13000	2.932e-217	709.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,43X0I@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
CMS2_k127_2370673_17	913865.DOT_1227	8.229e-50	181.0	COG1765@1|root,COG1765@2|Bacteria,1V7SN@1239|Firmicutes,24SS3@186801|Clostridia	186801|Clostridia	O	redox protein, regulator of disulfide bond	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
CMS2_k127_2370673_24	208439.AJAP_31295	1.785e-11	78.0	COG3469@1|root,COG3469@2|Bacteria,2GJH0@201174|Actinobacteria,4DZGS@85010|Pseudonocardiales	201174|Actinobacteria	G	Carbohydrate binding domain	chiA	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_2,CBM_4_9,CBM_5_12,Glyco_hydro_18,fn3
CMS2_k127_2370673_22	1237149.C900_00096	5.48e-18	99.0	COG3227@1|root,COG3291@1|root,COG4447@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,COG4447@2|Bacteria,4NEZQ@976|Bacteroidetes,47PGJ@768503|Cytophagia	976|Bacteroidetes	G	Participates in initiation and elongation during chromosome replication	-	-	-	-	-	-	-	-	-	-	-	-	MAM,Sortilin-Vps10
CMS2_k127_2370673_5	242619.PG_1424	4.008e-108	376.0	COG2957@1|root,COG2957@2|Bacteria	2|Bacteria	E	agmatine deiminase activity	-	GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0004198,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.22.37,3.5.3.12	ko:K08589,ko:K10536	ko00330,ko01100,ko01503,map00330,map01100,map01503	-	R01416	RC00177	ko00000,ko00001,ko01000,ko01002	-	-	-	PAD_porph
CMS2_k127_2370673_7	1237149.C900_05552	3.502e-92	338.0	COG3227@1|root,COG3291@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,4NJK3@976|Bacteroidetes,47TYM@768503|Cytophagia	976|Bacteroidetes	E	Pregnancy-associated plasma protein-A	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_M43,fn3
CMS2_k127_2370673_2	502025.Hoch_1667	1.173e-145	500.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_2370673_8	1121403.AUCV01000012_gene4109	2.88e-82	283.0	COG1075@1|root,COG1075@2|Bacteria,1QD4I@1224|Proteobacteria,435MR@68525|delta/epsilon subdivisions,2X9BC@28221|Deltaproteobacteria,2MNSY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2372691_0	522306.CAP2UW1_1132	1.607e-60	217.0	29GCA@1|root,303A5@2|Bacteria,1NC46@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2372691_2	1499967.BAYZ01000176_gene5640	5.576e-24	102.0	2DPW4@1|root,333N7@2|Bacteria	2|Bacteria	S	TIGRFAM YgiT-type zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2372691_1	1121403.AUCV01000045_gene1142	1.224e-57	211.0	COG1413@1|root,COG1413@2|Bacteria,1Q4WF@1224|Proteobacteria,4300V@68525|delta/epsilon subdivisions,2WV99@28221|Deltaproteobacteria,2MNIP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Protein of unknown function (DUF1186)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1186
CMS2_k127_2372691_4	933262.AXAM01000145_gene1521	0.000194	46.0	COG1672@1|root,COG1672@2|Bacteria,1R4NN@1224|Proteobacteria,42NMV@68525|delta/epsilon subdivisions,2WM2Z@28221|Deltaproteobacteria	2|Bacteria	S	PFAM Archaeal ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_13,AAA_22,AAA_35
CMS2_k127_2372691_3	1499967.BAYZ01000106_gene3549	8.344e-12	67.0	COG1672@1|root,COG1672@2|Bacteria	1499967.BAYZ01000106_gene3549|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2381360_0	1408422.JHYF01000017_gene1871	0.0	2297.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2381360_1	1499967.BAYZ01000119_gene3173	8.423e-54	196.0	28JE3@1|root,2Z98B@2|Bacteria,2NQ8M@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS2_k127_2381360_6	944547.ABLL_1453	7.509e-07	53.0	COG5635@1|root,COG5635@2|Bacteria,1NBP7@1224|Proteobacteria	1224|Proteobacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,NACHT
CMS2_k127_2381360_2	43989.cce_3074	2.425e-24	109.0	COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,3KHM4@43988|Cyanothece	1117|Cyanobacteria	Q	Acyl transferase domain in polyketide synthase (PKS) enzymes.	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2381360_4	525919.Apre_0831	1.257e-10	73.0	COG1533@1|root,COG1533@2|Bacteria,1V1PH@1239|Firmicutes	1239|Firmicutes	L	DNA photolyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2381360_3	28737.XP_006890581.1	3.992e-19	100.0	COG0457@1|root,KOG1130@1|root,KOG0548@2759|Eukaryota,KOG1130@2759|Eukaryota,38GAN@33154|Opisthokonta,3BEXQ@33208|Metazoa,3CSRU@33213|Bilateria,484N1@7711|Chordata,493P3@7742|Vertebrata,3JA6E@40674|Mammalia,350YT@311790|Afrotheria	33208|Metazoa	OT	Tetratricopeptide repeat protein	TTC28	GO:0000922,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005813,GO:0005815,GO:0005819,GO:0005856,GO:0007346,GO:0008150,GO:0015630,GO:0019899,GO:0019900,GO:0030496,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044422,GO:0044424,GO:0044430,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051233,GO:0051726,GO:0065007,GO:0072686,GO:0097431,GO:1990023	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_16,TPR_7,TPR_8
CMS2_k127_2388010_10	1123277.KB893180_gene2467	2.21e-140	458.0	COG0626@1|root,COG0626@2|Bacteria,4PKE6@976|Bacteroidetes,47KC8@768503|Cytophagia	976|Bacteroidetes	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	-	-	2.5.1.48,4.4.1.8	ko:K01739,ko:K01760	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
CMS2_k127_2388010_17	573413.Spirs_0115	4.727e-115	388.0	COG0044@1|root,COG0044@2|Bacteria,2J6KK@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
CMS2_k127_2388010_63	1045858.Bint_0074	2.035e-05	53.0	COG1396@1|root,COG2932@1|root,COG1396@2|Bacteria,COG2932@2|Bacteria,2J7N2@203691|Spirochaetes	203691|Spirochaetes	K	Peptidase S24-like	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
CMS2_k127_2388010_65	1094563.MCQ_01207	6.409e-05	51.0	COG1396@1|root,COG1396@2|Bacteria,1NDUD@1224|Proteobacteria,2UF9G@28211|Alphaproteobacteria,48SY6@772|Bartonellaceae	28211|Alphaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,Phage_CI_repr
CMS2_k127_2388010_35	1047013.AQSP01000082_gene1142	4.506e-63	225.0	COG1794@1|root,COG1794@2|Bacteria,2NR05@2323|unclassified Bacteria	2|Bacteria	M	Asp/Glu/Hydantoin racemase	racX	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
CMS2_k127_2388010_60	1423758.BN55_09955	4.229e-08	63.0	COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,4HKW3@91061|Bacilli,3F3SM@33958|Lactobacillaceae	91061|Bacilli	S	Helix-turn-helix domain	ymfM	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
CMS2_k127_2388010_50	1121918.ARWE01000001_gene2020	4.451e-26	121.0	2DMMW@1|root,32SIJ@2|Bacteria,1N004@1224|Proteobacteria,42TSJ@68525|delta/epsilon subdivisions,2WQHG@28221|Deltaproteobacteria,43TR3@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2388010_44	1196322.A370_04708	1.363e-39	162.0	COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5
CMS2_k127_2388010_55	760568.Desku_3249	4.603e-18	88.0	COG2009@1|root,COG2009@2|Bacteria,1VKGI@1239|Firmicutes,24VB1@186801|Clostridia	186801|Clostridia	C	TIGRFAM Succinate dehydrogenase, cytochrome b556 subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
CMS2_k127_2388010_57	644282.Deba_1090	2.363e-16	83.0	COG2142@1|root,COG2142@2|Bacteria,1Q5Y0@1224|Proteobacteria,4321V@68525|delta/epsilon subdivisions,2WX4X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
CMS2_k127_2388010_2	1131269.AQVV01000001_gene1359	7.799e-184	591.0	COG1053@1|root,COG1053@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071704,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0072350,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_0603,iJN746.PP_4191,iPC815.YPO1111	FAD_binding_2,Succ_DH_flav_C
CMS2_k127_2388010_30	517418.Ctha_1260	1.497e-83	283.0	COG0479@1|root,COG0479@2|Bacteria,1FEVT@1090|Chlorobi	1090|Chlorobi	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10
CMS2_k127_2388010_11	880073.Calab_3231	3.569e-140	457.0	COG0498@1|root,COG0498@2|Bacteria,2NP42@2323|unclassified Bacteria	2|Bacteria	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_2388010_4	880073.Calab_3230	2.262e-181	571.0	COG0078@1|root,COG0078@2|Bacteria,2NPA3@2323|unclassified Bacteria	2|Bacteria	E	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	ygeW	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0019627,GO:0034641,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS2_k127_2388010_5	880073.Calab_3229	2.59e-166	534.0	COG0624@1|root,COG0624@2|Bacteria,2NNX2@2323|unclassified Bacteria	2|Bacteria	E	Peptidase dimerisation domain	ygeY	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS2_k127_2388010_34	880073.Calab_3237	9.558e-67	230.0	COG2080@1|root,COG2080@2|Bacteria,2NPPX@2323|unclassified Bacteria	2|Bacteria	C	PFAM 2Fe-2S -binding	ndhS	-	1.17.1.5,1.2.5.3,1.3.99.16	ko:K03518,ko:K07302,ko:K13483,ko:K20446	ko00230,ko00760,ko01100,ko01120,map00230,map00760,map01100,map01120	M00546	R01720,R01768,R02103,R11168	RC00143,RC00589,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
CMS2_k127_2388010_0	1304888.ATWF01000001_gene573	5e-324	1024.0	COG0493@1|root,COG0493@2|Bacteria,2GF1T@200930|Deferribacteres	200930|Deferribacteres	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
CMS2_k127_2388010_49	1121396.KB893058_gene2571	2.39e-27	124.0	COG0348@1|root,COG0348@2|Bacteria,1PQG0@1224|Proteobacteria,42PV1@68525|delta/epsilon subdivisions,2WK8H@28221|Deltaproteobacteria,2MNNX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
CMS2_k127_2388010_51	1121405.dsmv_0115	1.178e-25	108.0	COG3360@1|root,COG3360@2|Bacteria,1Q2I5@1224|Proteobacteria,42VRR@68525|delta/epsilon subdivisions,2WRD2@28221|Deltaproteobacteria,2MM5C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
CMS2_k127_2388010_9	1443125.Z962_09815	1.013e-142	465.0	COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,24848@186801|Clostridia,36DHU@31979|Clostridiaceae	186801|Clostridia	F	pyrimidine-nucleoside phosphorylase	pdp	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08925	Glycos_trans_3N,Glycos_transf_3,PYNP_C
CMS2_k127_2388010_43	720554.Clocl_1976	1.383e-41	156.0	COG0295@1|root,COG0295@2|Bacteria,1V6IP@1239|Firmicutes,24JEM@186801|Clostridia,3WK22@541000|Ruminococcaceae	186801|Clostridia	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
CMS2_k127_2388010_62	991905.SL003B_4014	9.73e-06	53.0	COG1396@1|root,COG1396@2|Bacteria,1NDUD@1224|Proteobacteria,2UF9G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,Phage_CI_repr
CMS2_k127_2388010_59	395493.BegalDRAFT_0939	4.635e-09	63.0	COG1974@1|root,COG1974@2|Bacteria	2|Bacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31,Peptidase_S24
CMS2_k127_2388010_66	754027.HMPREF9554_01600	0.0002483	50.0	COG1396@1|root,COG1396@2|Bacteria,2J9HN@203691|Spirochaetes	203691|Spirochaetes	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19
CMS2_k127_2388010_58	1087481.AGFX01000022_gene2216	6.547e-14	76.0	COG0745@1|root,COG0745@2|Bacteria,1VUI6@1239|Firmicutes,4I7F9@91061|Bacilli,26TMP@186822|Paenibacillaceae	91061|Bacilli	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_2388010_19	1047013.AQSP01000140_gene2527	1.695e-104	361.0	COG1044@1|root,COG1044@2|Bacteria,2NQT1@2323|unclassified Bacteria	2|Bacteria	M	SpoIVB peptidase S55	-	-	2.7.7.24	ko:K00973,ko:K02414,ko:K21449	ko00521,ko00523,ko00525,ko01130,ko02040,map00521,map00523,map00525,map01130,map02040	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000,ko02035	1.B.40.2	-	-	AMP-binding,APH,DUF4114,DUF4842,Hexapep,PP-binding,Peptidase_S55
CMS2_k127_2388010_16	1047013.AQSP01000140_gene2528	4.634e-119	409.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114,DUF4347,DUF5122,LRR_5
CMS2_k127_2388010_12	1382315.JPOI01000001_gene2998	2.031e-138	450.0	COG0045@1|root,COG0045@2|Bacteria,1TQG4@1239|Firmicutes,4HA3W@91061|Bacilli,1WFFQ@129337|Geobacillus	91061|Bacilli	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU16090	ATP-grasp_2,Ligase_CoA
CMS2_k127_2388010_15	1121930.AQXG01000001_gene1296	4.001e-130	421.0	COG0074@1|root,COG0074@2|Bacteria,4NE6B@976|Bacteroidetes,1INZ1@117747|Sphingobacteriia	976|Bacteroidetes	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
CMS2_k127_2388010_39	391625.PPSIR1_08746	4.871e-53	199.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,43BQ2@68525|delta/epsilon subdivisions,2WQ6X@28221|Deltaproteobacteria,2Z2WS@29|Myxococcales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GGDEF,Yop-YscD_cpl
CMS2_k127_2388010_36	880073.Calab_3024	9.321e-58	214.0	COG0628@1|root,COG0628@2|Bacteria,2NPIB@2323|unclassified Bacteria	2|Bacteria	S	AI-2E family transporter	-	-	-	ko:K11744	-	-	-	-	ko00000	-	-	-	AI-2E_transport
CMS2_k127_2388010_18	909663.KI867150_gene1447	2.048e-107	361.0	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,42N40@68525|delta/epsilon subdivisions,2WKUV@28221|Deltaproteobacteria,2MRT9@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
CMS2_k127_2388010_33	696369.KI912183_gene226	8.676e-67	233.0	COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,261MS@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04225	Formyl_trans_N
CMS2_k127_2388010_14	1231377.C426_1633	1.008e-131	444.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,4HAWN@91061|Bacilli,1YB8B@1357|Lactococcus	91061|Bacilli	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
CMS2_k127_2388010_42	1047013.AQSP01000112_gene383	1.77e-42	164.0	COG0742@1|root,COG0742@2|Bacteria,2NPTA@2323|unclassified Bacteria	2|Bacteria	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
CMS2_k127_2388010_8	247633.GP2143_08674	6.936e-144	465.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1J4FV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NAD(P) transhydrogenase, alpha subunit	pntA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	iEcE24377_1341.EcE24377A_1810	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
CMS2_k127_2388010_48	1121403.AUCV01000007_gene1232	2.342e-29	119.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,42WKN@68525|delta/epsilon subdivisions,2WRXH@28221|Deltaproteobacteria,2MPR6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
CMS2_k127_2388010_3	595460.RRSWK_03299	1.9e-182	582.0	COG1282@1|root,COG1282@2|Bacteria,2IYIA@203682|Planctomycetes	203682|Planctomycetes	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
CMS2_k127_2388010_31	204669.Acid345_3013	1.176e-82	286.0	COG0395@1|root,COG0395@2|Bacteria,3Y7HR@57723|Acidobacteria	57723|Acidobacteria	G	Inward rectifier potassium channel	-	-	-	ko:K08715	-	-	-	-	ko00000,ko02000	1.A.2.2	-	-	IRK
CMS2_k127_2388010_22	243275.TDE_2210	8.857e-99	337.0	2EYV8@1|root,33S2C@2|Bacteria,2J65B@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1565
CMS2_k127_2388010_1	868864.Dester_1146	2.154e-305	973.0	COG0587@1|root,COG0587@2|Bacteria,2G3PZ@200783|Aquificae	200783|Aquificae	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
CMS2_k127_2388010_41	1047013.AQSP01000132_gene1746	2.408e-47	180.0	COG0543@1|root,COG0543@2|Bacteria,2NPJH@2323|unclassified Bacteria	2|Bacteria	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	1.3.1.14,3.5.2.3	ko:K01465,ko:K02823,ko:K05784,ko:K17828	ko00240,ko00362,ko00364,ko00622,ko01100,ko01120,ko01220,map00240,map00362,map00364,map00622,map01100,map01120,map01220	M00051,M00551	R01869,R01993,R05290,R05291,R05428,R05621,R05622,R05665,R08100,R08101,R08108,R08109,R08110	RC00051,RC00270,RC00632,RC01378,RC01450,RC01910	br01602,ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17580	DHODB_Fe-S_bind,FAD_binding_6,Fer2,NAD_binding_1
CMS2_k127_2388010_20	1047013.AQSP01000132_gene1745	1.086e-103	346.0	COG0167@1|root,COG0167@2|Bacteria,2NNVA@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.5.2,1.3.98.1	ko:K00226,ko:K00254,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01867,R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15540	DHO_dh
CMS2_k127_2388010_37	1047013.AQSP01000132_gene1744	7.908e-57	205.0	COG0284@1|root,COG0284@2|Bacteria,2NQYX@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750	OMPdecase
CMS2_k127_2388010_68	865937.Gilli_1838	0.0002894	53.0	COG0612@1|root,COG0612@2|Bacteria,4NEPT@976|Bacteroidetes,1HWQI@117743|Flavobacteriia,2P6K5@244698|Gillisia	976|Bacteroidetes	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_2388010_53	1183438.GKIL_3767	2.552e-22	111.0	COG0612@1|root,COG0612@2|Bacteria,1G1CD@1117|Cyanobacteria	1117|Cyanobacteria	S	Belongs to the peptidase M16 family	pqqE	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_2388010_67	1121918.ARWE01000001_gene2796	0.00026	50.0	COG3266@1|root,COG3266@2|Bacteria,1N3DN@1224|Proteobacteria,42TS8@68525|delta/epsilon subdivisions,2WR5F@28221|Deltaproteobacteria,43SPH@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2388010_24	857293.CAAU_0021	4.339e-95	323.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,36EGP@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the acetokinase family	buk	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044464,GO:0047761	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
CMS2_k127_2388010_26	1499967.BAYZ01000155_gene651	1.58e-93	315.0	COG0005@1|root,COG0005@2|Bacteria,2NNYQ@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2684	PNP_UDP_1
CMS2_k127_2388010_40	706587.Desti_2861	1.14e-52	207.0	COG0464@1|root,COG0464@2|Bacteria,1NY8M@1224|Proteobacteria,43B3R@68525|delta/epsilon subdivisions,2X6HN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS2_k127_2388010_28	1121403.AUCV01000010_gene1382	4.042e-89	308.0	COG1116@1|root,COG1116@2|Bacteria,1MWZG@1224|Proteobacteria,43CBE@68525|delta/epsilon subdivisions	1224|Proteobacteria	P	ABC transporter	cysA_3	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
CMS2_k127_2388010_29	926549.KI421517_gene1389	2.937e-87	297.0	COG0600@1|root,COG0600@2|Bacteria	2|Bacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	tauC	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
CMS2_k127_2388010_7	926549.KI421517_gene1388	2.033e-144	465.0	COG0715@1|root,COG0715@2|Bacteria,4NM1E@976|Bacteroidetes	976|Bacteroidetes	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2,OmpA
CMS2_k127_2388010_64	335543.Sfum_3486	2.267e-05	55.0	2E2S0@1|root,32XUC@2|Bacteria,1N3J9@1224|Proteobacteria,430ZJ@68525|delta/epsilon subdivisions,2WW5B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2388010_27	1121403.AUCV01000010_gene1377	2.204e-92	323.0	COG2885@1|root,COG3221@1|root,COG2885@2|Bacteria,COG3221@2|Bacteria,1R687@1224|Proteobacteria,42ZCB@68525|delta/epsilon subdivisions,2WTSU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MP	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1,OmpA
CMS2_k127_2388010_45	335543.Sfum_3488	1.088e-35	146.0	COG2304@1|root,COG2304@2|Bacteria,1RGCN@1224|Proteobacteria,4302M@68525|delta/epsilon subdivisions,2WVBD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
CMS2_k127_2388010_13	1121403.AUCV01000010_gene1375	2.908e-137	456.0	COG0715@1|root,COG0715@2|Bacteria,1QU25@1224|Proteobacteria,42YRH@68525|delta/epsilon subdivisions,2WUGB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
CMS2_k127_2388010_54	96561.Dole_2512	1.521e-20	96.0	COG3086@1|root,COG3086@2|Bacteria,1PKXC@1224|Proteobacteria,42UU9@68525|delta/epsilon subdivisions,2WPMZ@28221|Deltaproteobacteria,2MK8X@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Positive regulator of sigma(E) RseC MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
CMS2_k127_2388010_38	335543.Sfum_2805	8.553e-55	203.0	COG0509@1|root,COG0509@2|Bacteria,1Q1KI@1224|Proteobacteria,437BG@68525|delta/epsilon subdivisions,2X2GI@28221|Deltaproteobacteria,2MRJR@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	GCV_H
CMS2_k127_2388010_47	234267.Acid_0393	1.705e-30	126.0	COG1913@1|root,COG1913@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
CMS2_k127_2388010_6	945713.IALB_2429	1.356e-154	501.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02481,ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_2388010_32	1382306.JNIM01000001_gene4019	2.108e-78	292.0	COG1413@1|root,COG5635@1|root,COG1413@2|Bacteria,COG5635@2|Bacteria,2G8R0@200795|Chloroflexi	200795|Chloroflexi	CT	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,NACHT
CMS2_k127_2388010_69	99598.Cal7507_0626	0.0007019	51.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G20P@1117|Cyanobacteria,1HIFJ@1161|Nostocales	1117|Cyanobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_1,TPR_11,TPR_2,TPR_8
CMS2_k127_2388010_25	714943.Mucpa_1493	2.422e-94	316.0	COG0384@1|root,COG0384@2|Bacteria,4NEWM@976|Bacteroidetes,1IP44@117747|Sphingobacteriia	976|Bacteroidetes	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
CMS2_k127_2388010_52	592015.HMPREF1705_00870	1.703e-25	116.0	COG1639@1|root,COG1639@2|Bacteria,3TADU@508458|Synergistetes	508458|Synergistetes	T	PFAM Metal-dependent hydrolase HDOD	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
CMS2_k127_2388010_23	243231.GSU0804	1.259e-96	319.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,42PF5@68525|delta/epsilon subdivisions,2WMD8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the WrbA family	wrbA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0771	FMN_red
CMS2_k127_2388010_21	278963.ATWD01000002_gene473	2.281e-101	341.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	mdsC	-	2.7.1.162,2.7.1.39	ko:K02204,ko:K13059	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771,R08962	RC00002,RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
CMS2_k127_2412286_11	439235.Dalk_2288	2.444e-52	209.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,2MPW6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4150,RHS,RHS_repeat,Transglut_core
CMS2_k127_2412286_15	1298593.TOL_0428	5.359e-23	115.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566,Flg_new,Inhibitor_I69,LRR_5,Peptidase_C10
CMS2_k127_2412286_17	697282.Mettu_3235	9.609e-05	57.0	COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,1RQ12@1236|Gammaproteobacteria,1XDZB@135618|Methylococcales	135618|Methylococcales	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
CMS2_k127_2412286_12	1458462.JNLK01000001_gene646	1.729e-34	150.0	COG0515@1|root,COG0515@2|Bacteria,1TPYP@1239|Firmicutes,24ABN@186801|Clostridia,27IE6@186928|unclassified Lachnospiraceae	186801|Clostridia	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_2412286_14	237368.SCABRO_02744	1.141e-27	129.0	COG0515@1|root,COG4249@1|root,COG0515@2|Bacteria,COG4249@2|Bacteria,2J1KC@203682|Planctomycetes	2|Bacteria	KLT	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,SLH,TPR_2,TPR_8
CMS2_k127_2412286_13	1353529.M899_2215	1.692e-30	132.0	COG0558@1|root,COG0558@2|Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.34	ko:K07291	ko00562,map00562	-	R09670	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS2_k127_2412286_10	573413.Spirs_2250	1.405e-62	228.0	COG1638@1|root,COG1638@2|Bacteria,2J5PX@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
CMS2_k127_2412286_2	1122176.KB903576_gene5032	3.485e-236	780.0	COG2319@1|root,COG4995@1|root,COG2319@2|Bacteria,COG4995@2|Bacteria,4P49H@976|Bacteroidetes	976|Bacteroidetes	H	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
CMS2_k127_2412286_9	760192.Halhy_5505	5.488e-78	285.0	COG1075@1|root,COG4249@1|root,COG1075@2|Bacteria,COG4249@2|Bacteria,4P04T@976|Bacteroidetes	976|Bacteroidetes	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2412286_8	1047013.AQSP01000123_gene1522	9.255e-107	375.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_2412286_4	1121121.KB894289_gene2673	3.944e-176	592.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_31,PP-binding
CMS2_k127_2412286_5	316274.Haur_1880	1.356e-169	542.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	DUF3326
CMS2_k127_2412286_7	316274.Haur_1879	2.687e-116	396.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	pvdI	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,PP-binding,Thioesterase
CMS2_k127_2412286_0	1200792.AKYF01000010_gene2343	0.0	2517.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2412286_6	509191.AEDB02000067_gene916	1.637e-165	538.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_2412286_3	509191.AEDB02000067_gene917	1.388e-197	648.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WNP0@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2412286_1	1007103.AFHW01000087_gene6303	0.0	1549.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2474357_7	1191523.MROS_2005	1.129e-136	472.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2474357_32	1313301.AUGC01000013_gene1290	3.172e-42	179.0	COG3227@1|root,COG3227@2|Bacteria,4NF8H@976|Bacteroidetes	976|Bacteroidetes	E	Thermolysin metallopeptidase, catalytic domain	-	-	3.4.24.28	ko:K01400	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	FTP,MAM,PepSY,Peptidase_M4,Peptidase_M4_C,fn3
CMS2_k127_2474357_57	373994.Riv7116_6577	0.0003276	44.0	COG3093@1|root,COG3093@2|Bacteria,1G7RY@1117|Cyanobacteria,1HNYJ@1161|Nostocales	1117|Cyanobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
CMS2_k127_2474357_17	1333523.L593_02375	1.188e-85	308.0	COG3291@1|root,arCOG03509@1|root,arCOG02546@2157|Archaea,arCOG03509@2157|Archaea,2Y7ZF@28890|Euryarchaeota,24143@183963|Halobacteria	183963|Halobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
CMS2_k127_2474357_22	690850.Desaf_0855	2.075e-75	261.0	COG0596@1|root,COG0596@2|Bacteria,1NEZY@1224|Proteobacteria,435WB@68525|delta/epsilon subdivisions,2X0CF@28221|Deltaproteobacteria,2MBTM@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
CMS2_k127_2474357_58	1449351.RISW2_00605	0.0003919	51.0	COG3637@1|root,COG3637@2|Bacteria,1RBBG@1224|Proteobacteria,2U5ED@28211|Alphaproteobacteria,4KKZT@93682|Roseivivax	28211|Alphaproteobacteria	M	Lipid A oxidase (Involved in formation of 2-aminogluconate) protein	lpxQ	-	-	ko:K12980	-	-	-	-	ko00000,ko01005	-	-	-	OMP_b-brl
CMS2_k127_2474357_9	338969.Rfer_3235	1.58e-130	451.0	COG0464@1|root,COG0790@1|root,COG0464@2|Bacteria,COG0790@2|Bacteria,1MUCN@1224|Proteobacteria,2VIA8@28216|Betaproteobacteria,4AHQ6@80864|Comamonadaceae	28216|Betaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS2_k127_2474357_39	543526.Htur_2953	1.362e-28	125.0	COG0500@1|root,arCOG01402@2157|Archaea,2XYWP@28890|Euryarchaeota,23WPJ@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
CMS2_k127_2474357_11	1265505.ATUG01000002_gene1947	1.302e-111	384.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42QM3@68525|delta/epsilon subdivisions,2WKI2@28221|Deltaproteobacteria,2MI4S@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
CMS2_k127_2474357_8	398512.JQKC01000015_gene4640	3.177e-134	435.0	COG0031@1|root,COG0031@2|Bacteria,1V396@1239|Firmicutes,24AZ8@186801|Clostridia,3WJ6S@541000|Ruminococcaceae	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.140	ko:K21949	-	-	R11705	-	ko00000,ko01000	-	-	-	PALP
CMS2_k127_2474357_6	398512.JQKC01000015_gene4641	5.22e-137	444.0	COG2423@1|root,COG2423@2|Bacteria,1TQIY@1239|Firmicutes,258T1@186801|Clostridia,3WNMD@541000|Ruminococcaceae	186801|Clostridia	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	OCD_Mu_crystall
CMS2_k127_2474357_16	926550.CLDAP_15620	6.565e-89	309.0	COG0285@1|root,COG0285@2|Bacteria,2G64M@200795|Chloroflexi	200795|Chloroflexi	H	PFAM cytoplasmic peptidoglycan synthetase domain protein	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
CMS2_k127_2474357_18	643648.Slip_1551	1.513e-78	271.0	COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,24827@186801|Clostridia,42KBI@68298|Syntrophomonadaceae	186801|Clostridia	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
CMS2_k127_2474357_30	1232437.KL661960_gene3068	2.206e-47	173.0	COG1586@1|root,COG1586@2|Bacteria,1RH88@1224|Proteobacteria,42TPF@68525|delta/epsilon subdivisions,2WR03@28221|Deltaproteobacteria,2MJRQ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
CMS2_k127_2474357_35	387092.NIS_1526	2.865e-36	143.0	COG1586@1|root,COG1586@2|Bacteria,1RH88@1224|Proteobacteria,42TPF@68525|delta/epsilon subdivisions	1224|Proteobacteria	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	2.5.1.128,2.5.1.16,4.1.1.50	ko:K00797,ko:K01611,ko:K07057	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R00178,R01920,R02869,R08359	RC00021,RC00053,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
CMS2_k127_2474357_4	323261.Noc_1671	4.206e-156	507.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1WWAI@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
CMS2_k127_2474357_44	1232410.KI421428_gene1212	4.952e-14	84.0	COG0457@1|root,COG0457@2|Bacteria,1R7XY@1224|Proteobacteria,42NFC@68525|delta/epsilon subdivisions,2WMA4@28221|Deltaproteobacteria,43S9G@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
CMS2_k127_2474357_23	795359.TOPB45_0219	1.539e-74	260.0	COG0324@1|root,COG0324@2|Bacteria,2GH70@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
CMS2_k127_2474357_53	394503.Ccel_0602	5.586e-07	62.0	COG0457@1|root,COG0457@2|Bacteria,1UYZH@1239|Firmicutes,24BU9@186801|Clostridia,36NTK@31979|Clostridiaceae	186801|Clostridia	S	Anaphase-promoting complex, cyclosome, subunit 3	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
CMS2_k127_2474357_46	1047013.AQSP01000131_gene1799	1.452e-12	76.0	28MUS@1|root,2ZB2I@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4412)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4412
CMS2_k127_2474357_43	1300150.EMQU_0514	2.027e-14	77.0	COG2207@1|root,COG2207@2|Bacteria,1UZ0Q@1239|Firmicutes,4IPX1@91061|Bacilli,4B1C6@81852|Enterococcaceae	91061|Bacilli	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
CMS2_k127_2474357_48	1121346.KB899810_gene1520	2.319e-10	65.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V0SB@1239|Firmicutes,4HFM1@91061|Bacilli,274BY@186822|Paenibacillaceae	91061|Bacilli	T	COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
CMS2_k127_2474357_10	1121121.KB894288_gene2760	4.911e-123	400.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4HFI6@91061|Bacilli,26TDV@186822|Paenibacillaceae	91061|Bacilli	I	Dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
CMS2_k127_2474357_54	1280390.CBQR020000153_gene4118	2.678e-05	52.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V0SB@1239|Firmicutes,4HFM1@91061|Bacilli,274BY@186822|Paenibacillaceae	91061|Bacilli	T	COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
CMS2_k127_2474357_40	1280390.CBQR020000128_gene3175	1.168e-27	122.0	COG3208@1|root,COG3208@2|Bacteria,1V3KR@1239|Firmicutes,4HHC8@91061|Bacilli,26XR6@186822|Paenibacillaceae	91061|Bacilli	Q	thioesterase involved in non-ribosomal peptide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Thioesterase
CMS2_k127_2474357_28	1280681.AUJZ01000001_gene918	2.748e-52	191.0	COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,24H8J@186801|Clostridia,4BY6N@830|Butyrivibrio	186801|Clostridia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CMS2_k127_2474357_2	1120985.AUMI01000015_gene1443	4.001e-186	603.0	COG0326@1|root,COG0326@2|Bacteria,1TQEU@1239|Firmicutes,4H2HJ@909932|Negativicutes	909932|Negativicutes	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
CMS2_k127_2474357_31	161156.JQKW01000013_gene129	4.025e-43	162.0	COG0698@1|root,COG0698@2|Bacteria,2GH7Z@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
CMS2_k127_2474357_42	1121920.AUAU01000002_gene2096	3.278e-20	100.0	COG4758@1|root,COG4758@2|Bacteria,3Y554@57723|Acidobacteria	57723|Acidobacteria	S	Cell wall-active antibiotics response 4TMS YvqF	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
CMS2_k127_2474357_27	70448.A0A096P7V1	5.253e-66	255.0	COG1643@1|root,KOG0922@2759|Eukaryota,37I67@33090|Viridiplantae,34GVA@3041|Chlorophyta	3041|Chlorophyta	A	RNA helicase	-	-	3.6.4.13	ko:K12818	ko03040,map03040	-	-	-	ko00000,ko00001,ko01000,ko03041	-	-	-	DEAD,HA2,Helicase_C,OB_NTP_bind
CMS2_k127_2474357_1	468059.AUHA01000005_gene2429	2.672e-192	650.0	COG0642@1|root,COG3292@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,1IRJZ@117747|Sphingobacteriia	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA,PAS_9,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_2474357_52	1047013.AQSP01000130_gene1884	9.74e-08	64.0	COG1520@1|root,COG4447@1|root,COG1520@2|Bacteria,COG4447@2|Bacteria,2NQN9@2323|unclassified Bacteria	2|Bacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
CMS2_k127_2474357_33	1265505.ATUG01000001_gene3541	1.824e-41	164.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,42P86@68525|delta/epsilon subdivisions,2WN8T@28221|Deltaproteobacteria,2MJWP@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
CMS2_k127_2474357_29	394503.Ccel_0175	2.065e-48	185.0	COG0696@1|root,COG0696@2|Bacteria,1UYDB@1239|Firmicutes,24BJ3@186801|Clostridia,36IFK@31979|Clostridiaceae	186801|Clostridia	C	Metalloenzyme superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme
CMS2_k127_2474357_21	929556.Solca_2058	2.291e-76	271.0	COG0477@1|root,COG2814@2|Bacteria,4NEUU@976|Bacteroidetes,1INWC@117747|Sphingobacteriia	976|Bacteroidetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
CMS2_k127_2474357_50	1121422.AUMW01000001_gene2371	1.986e-08	64.0	COG5581@1|root,COG5581@2|Bacteria,1VERW@1239|Firmicutes,258VW@186801|Clostridia,262Q2@186807|Peptococcaceae	186801|Clostridia	M	Flagellar protein YcgR	-	-	-	-	-	-	-	-	-	-	-	-	PilZ,YcgR_2
CMS2_k127_2474357_47	1304284.L21TH_0674	1.269e-11	78.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,36DBS@31979|Clostridiaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_2474357_51	1165841.SULAR_02438	3.348e-08	62.0	COG0666@1|root,COG0666@2|Bacteria,1RBYV@1224|Proteobacteria,42TI1@68525|delta/epsilon subdivisions,2YTNI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_4
CMS2_k127_2474357_12	552811.Dehly_1197	2.937e-108	366.0	COG4826@1|root,COG4826@2|Bacteria,2GBWN@200795|Chloroflexi,34D50@301297|Dehalococcoidia	301297|Dehalococcoidia	M	SERine  Proteinase INhibitors	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
CMS2_k127_2474357_56	742725.HMPREF9450_01896	9.971e-05	50.0	COG3187@1|root,COG3187@2|Bacteria,4NXH7@976|Bacteroidetes,2G1GF@200643|Bacteroidia,22UKR@171550|Rikenellaceae	976|Bacteroidetes	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
CMS2_k127_2474357_55	172045.KS04_03115	3.883e-05	53.0	COG3637@1|root,COG3637@2|Bacteria,4NVT2@976|Bacteroidetes,1I8VN@117743|Flavobacteriia,34RGW@308865|Elizabethkingia	976|Bacteroidetes	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl_2
CMS2_k127_2474357_24	1385521.N803_08335	1.907e-72	261.0	COG0448@1|root,COG0448@2|Bacteria,2I2EF@201174|Actinobacteria,4FEM7@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CMS2_k127_2474357_45	926550.CLDAP_33710	7.957e-14	86.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
CMS2_k127_2474357_37	1100720.ALKN01000030_gene1023	9.053e-36	158.0	COG0823@1|root,COG3291@1|root,COG0823@2|Bacteria,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria	1224|Proteobacteria	U	PKD domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PKD,REJ
CMS2_k127_2474357_49	1047013.AQSP01000084_gene765	6.188e-09	65.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
CMS2_k127_2474357_14	1163389.OOM_0020	7.869e-103	342.0	COG1073@1|root,COG1073@2|Bacteria,1MUCD@1224|Proteobacteria,1RPCZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Dienelactone hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	DLH,DUF1100,Hydrolase_4,Peptidase_S15,Peptidase_S9
CMS2_k127_2474357_5	880073.Calab_2857	3.808e-153	509.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	DUF2808,Peptidase_S46
CMS2_k127_2474357_3	880073.Calab_2857	1.35e-162	537.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	DUF2808,Peptidase_S46
CMS2_k127_2474357_25	96561.Dole_1695	4.27e-71	253.0	COG1145@1|root,COG1145@2|Bacteria,1MW11@1224|Proteobacteria,42NUY@68525|delta/epsilon subdivisions,2WK01@28221|Deltaproteobacteria,2MMY1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
CMS2_k127_2474357_0	1499967.BAYZ01000089_gene5053	1.068e-243	767.0	COG0514@1|root,COG0514@2|Bacteria,2NNZU@2323|unclassified Bacteria	2|Bacteria	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
CMS2_k127_2474357_34	247490.KSU1_C0604	3.899e-41	155.0	COG1186@1|root,COG1186@2|Bacteria,2J05G@203682|Planctomycetes	203682|Planctomycetes	J	chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
CMS2_k127_2474357_19	1123037.AUDE01000035_gene229	1.572e-77	266.0	COG0020@1|root,COG0020@2|Bacteria,4NF2B@976|Bacteroidetes,1HXRP@117743|Flavobacteriia	976|Bacteroidetes	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
CMS2_k127_2474357_36	1047013.AQSP01000091_gene647	8.79e-36	146.0	COG4589@1|root,COG4589@2|Bacteria,2NPVB@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
CMS2_k127_2474357_13	665959.HMPREF1013_00288	2.567e-103	349.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,4HBAV@91061|Bacilli,1ZC3I@1386|Bacillus	91061|Bacilli	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
CMS2_k127_2474357_15	1047013.AQSP01000091_gene645	1.104e-94	329.0	COG0750@1|root,COG0750@2|Bacteria,2NP7C@2323|unclassified Bacteria	2|Bacteria	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
CMS2_k127_2474357_38	63737.Npun_R1288	2.046e-31	139.0	COG1020@1|root,COG1020@2|Bacteria,1G2QF@1117|Cyanobacteria,1HIRK@1161|Nostocales	1117|Cyanobacteria	Q	protein containing a NRPS condensation (Elongation) domain	-	-	-	-	-	-	-	-	-	-	-	-	AATase,Condensation
CMS2_k127_2474357_26	1121405.dsmv_1640	1.749e-68	254.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42QS7@68525|delta/epsilon subdivisions,2X74U@28221|Deltaproteobacteria,2MN9G@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,Acyltransferase,PP-binding
CMS2_k127_250692_3	324925.Ppha_1712	3.365e-55	206.0	COG0457@1|root,COG0457@2|Bacteria,1FEHQ@1090|Chlorobi	1090|Chlorobi	S	SMART Tetratricopeptide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_250692_0	247490.KSU1_C0714	2.582e-102	375.0	COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes	203682|Planctomycetes	O	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
CMS2_k127_250692_4	269798.CHU_1105	6.749e-18	100.0	COG3656@1|root,COG3656@2|Bacteria,4NHDQ@976|Bacteroidetes	976|Bacteroidetes	UW	fibronectin type III domain protein	-	-	-	ko:K21571	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_250692_2	439235.Dalk_0237	4.698e-96	355.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_250692_5	639030.JHVA01000001_gene2309	4.78e-05	49.0	COG1487@1|root,COG1487@2|Bacteria,3Y5X8@57723|Acidobacteria,2JK5Q@204432|Acidobacteriia	204432|Acidobacteriia	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
CMS2_k127_250692_1	439235.Dalk_0237	3.335e-100	353.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_2511298_0	1007103.AFHW01000006_gene4244	1.683e-179	585.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	pmxE	-	-	ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2511298_1	509191.AEDB02000067_gene917	9.896e-86	299.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WNP0@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_251274_23	177437.HRM2_34080	5.464e-45	185.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,1N26H@1224|Proteobacteria,43EV4@68525|delta/epsilon subdivisions,2WR4K@28221|Deltaproteobacteria,2MNP4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS2_k127_251274_26	768671.ThimaDRAFT_4637	8.536e-21	108.0	COG1409@1|root,COG1409@2|Bacteria,1N8PY@1224|Proteobacteria,1SZFU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_251274_18	760192.Halhy_1386	7.774e-110	374.0	COG1409@1|root,COG1409@2|Bacteria,4NF9K@976|Bacteroidetes,1IPY7@117747|Sphingobacteriia	976|Bacteroidetes	S	C terminal of Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,MetallophosC,MetallophosN
CMS2_k127_251274_25	631362.Thi970DRAFT_01310	6.019e-35	139.0	COG4194@1|root,COG4194@2|Bacteria,1QTGM@1224|Proteobacteria,1SVXJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1648)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648
CMS2_k127_251274_27	2340.JV46_16800	3.744e-09	63.0	2DPPJ@1|root,332WE@2|Bacteria,1NMBJ@1224|Proteobacteria,1SSBR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_251274_21	468059.AUHA01000004_gene2375	4.623e-57	211.0	2BXBG@1|root,33WQF@2|Bacteria,4P3CB@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_251274_29	1530186.JQEY01000001_gene893	0.0001527	46.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
CMS2_k127_251274_15	398512.JQKC01000015_gene4634	5.643e-141	457.0	COG0826@1|root,COG0826@2|Bacteria,1VT69@1239|Firmicutes,25DBH@186801|Clostridia	186801|Clostridia	O	Peptidase family U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
CMS2_k127_251274_17	1047013.AQSP01000139_gene2323	2.193e-135	457.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_251274_11	1196323.ALKF01000205_gene4118	1.106e-299	962.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes	1239|Firmicutes	Q	synthase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_251274_0	1042163.BRLA_c025640	0.0	2640.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_251274_1	1042163.BRLA_c023740	0.0	2431.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_251274_19	192952.MM_0133	8.616e-103	349.0	COG0498@1|root,arCOG01434@2157|Archaea,2XUJC@28890|Euryarchaeota,2N9BY@224756|Methanomicrobia	224756|Methanomicrobia	H	Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate	-	-	2.5.1.76	ko:K15527	-	-	-	-	ko00000,ko01000	-	-	-	PALP
CMS2_k127_251274_24	525904.Tter_0037	3.734e-37	149.0	COG0175@1|root,COG0175@2|Bacteria,2NPHM@2323|unclassified Bacteria	2|Bacteria	EH	Belongs to the PAPS reductase family. CysH subfamily	cysH	GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114	1.8.4.10,1.8.4.8,2.7.1.25	ko:K00390,ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R02021,R04928	RC00002,RC00007,RC00078,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15570	PAPS_reduct
CMS2_k127_251274_13	711393.AYRX01000103_gene5911	9.772e-145	477.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_251274_4	697284.ERIC2_c18050	0.0	2006.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_251274_6	573061.Clocel_2487	0.0	1381.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_251274_16	711393.AYRX01000103_gene5911	2.438e-140	464.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_251274_7	755731.Clo1100_2632	0.0	1125.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_251274_28	1121344.JHZO01000006_gene1957	7.302e-05	46.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,3WG9U@541000|Ruminococcaceae	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS2_k127_251274_3	1009370.ALO_00935	0.0	2290.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_251274_5	573061.Clocel_2482	0.0	1431.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_251274_10	649747.HMPREF0083_00279	5.924e-301	977.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16123,ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_251274_9	1408422.JHYF01000001_gene2874	6.045e-311	998.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654,ko:K15664	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_251274_12	1122921.KB898216_gene2722	2.617e-250	872.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_251274_2	1196323.ALKF01000205_gene4114	0.0	2334.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_251274_14	398512.JQKC01000015_gene4634	4.514e-141	458.0	COG0826@1|root,COG0826@2|Bacteria,1VT69@1239|Firmicutes,25DBH@186801|Clostridia	186801|Clostridia	O	Peptidase family U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
CMS2_k127_251274_8	880073.Calab_0529	0.0	1124.0	COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,2NRCG@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M28	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	iAF987.Gmet_0348	Cofac_haem_bdg,PA,PDZ_2,Peptidase_M1,Peptidase_M28,Trypsin_2
CMS2_k127_251274_22	1449126.JQKL01000009_gene362	2.004e-53	198.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,25CC4@186801|Clostridia,26BI4@186813|unclassified Clostridiales	186801|Clostridia	EH	Amino-transferase class IV	ilvE2	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CMS2_k127_251274_20	555088.DealDRAFT_0340	2.125e-102	346.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,42JYU@68298|Syntrophomonadaceae	186801|Clostridia	H	anthranilate synthase, component	pabB	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665,ko:K13503,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind,GATase
CMS2_k127_253596_0	1121121.KB894288_gene2764	0.0	1853.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_253596_1	1077285.AGDG01000012_gene3501	5.951e-139	462.0	COG1429@1|root,COG1429@2|Bacteria,4P0BG@976|Bacteroidetes,2FMJ7@200643|Bacteroidia,4AN00@815|Bacteroidaceae	976|Bacteroidetes	H	COG NOG08812 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,PDDEXK_9
CMS2_k127_2545744_6	323259.Mhun_0597	1.137e-17	98.0	COG3291@1|root,arCOG02559@1|root,arCOG06792@1|root,arCOG02508@2157|Archaea,arCOG02559@2157|Archaea,arCOG06792@2157|Archaea,2XUY6@28890|Euryarchaeota,2NAFS@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PKD
CMS2_k127_2545744_8	1291050.JAGE01000001_gene3168	3.298e-07	64.0	COG3103@1|root,COG3266@1|root,COG4870@1|root,COG3266@2|Bacteria,COG4870@2|Bacteria,COG4991@2|Bacteria,1VDA3@1239|Firmicutes	1239|Firmicutes	O	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Flg_new,TPR_19
CMS2_k127_2545744_2	439235.Dalk_0237	6.182e-90	324.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_2545744_3	439235.Dalk_0237	6.48e-77	281.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_2545744_4	1047013.AQSP01000028_gene2077	9.997e-63	223.0	COG0681@1|root,COG0681@2|Bacteria,2NPIA@2323|unclassified Bacteria	2|Bacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
CMS2_k127_2545744_0	1408473.JHXO01000008_gene2886	1.055e-296	934.0	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,2FS4M@200643|Bacteroidia	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_2545744_5	29581.BW37_04425	3.281e-20	92.0	2EK70@1|root,33DXD@2|Bacteria,1NA99@1224|Proteobacteria,2WCK9@28216|Betaproteobacteria,477U2@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2545744_7	1232437.KL662026_gene969	4.172e-14	82.0	COG2020@1|root,COG2020@2|Bacteria,1RBJE@1224|Proteobacteria,42XPQ@68525|delta/epsilon subdivisions,2WT34@28221|Deltaproteobacteria,2MMDN@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CMS2_k127_2545744_1	1345695.CLSA_c37640	9.951e-125	425.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36QT1@31979|Clostridiaceae	186801|Clostridia	Q	Phosphopantetheine attachment site	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_31,NAD_binding_4,PP-binding
CMS2_k127_255570_0	755178.Cyan10605_1171	3.906e-14	85.0	COG0206@1|root,COG0206@2|Bacteria,1G357@1117|Cyanobacteria	1117|Cyanobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	-	-	-	-	-	-	-	-	-	Tubulin_2
CMS2_k127_255570_1	742733.HMPREF9469_00287	0.0003818	52.0	COG2304@1|root,COG2304@2|Bacteria,1V57M@1239|Firmicutes,25BGX@186801|Clostridia	186801|Clostridia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_256390_19	927658.AJUM01000043_gene687	4.455e-108	358.0	COG2271@1|root,COG2271@2|Bacteria,4PKTC@976|Bacteroidetes,2G3HT@200643|Bacteroidia	976|Bacteroidetes	G	Transporter, major facilitator family protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS2_k127_256390_5	1499967.BAYZ01000026_gene1631	7.231e-192	618.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS2_k127_256390_52	1499967.BAYZ01000005_gene5436	5.053e-46	186.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,2NQY2@2323|unclassified Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT,PMT_2,TPR_19
CMS2_k127_256390_62	401053.AciPR4_2577	7.657e-29	118.0	COG1366@1|root,COG1366@2|Bacteria,3Y4U6@57723|Acidobacteria,2JJH2@204432|Acidobacteriia	204432|Acidobacteriia	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS2_k127_256390_42	649747.HMPREF0083_03159	5.379e-67	239.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,4H9V5@91061|Bacilli,26RIB@186822|Paenibacillaceae	91061|Bacilli	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
CMS2_k127_256390_37	926549.KI421517_gene1670	8.737e-74	262.0	COG0153@1|root,COG0153@2|Bacteria,4NFSD@976|Bacteroidetes,47K00@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
CMS2_k127_256390_73	1123371.ATXH01000013_gene1528	1.304e-07	63.0	COG1475@1|root,COG1475@2|Bacteria,2GHDV@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
CMS2_k127_256390_15	1168034.FH5T_11060	1.606e-120	412.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
CMS2_k127_256390_11	1047013.AQSP01000067_gene2201	4.012e-155	512.0	COG3379@1|root,COG3379@2|Bacteria,2NQIG@2323|unclassified Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
CMS2_k127_256390_46	1379698.RBG1_1C00001G0810	3.722e-55	199.0	COG4122@1|root,COG4122@2|Bacteria,2NPV6@2323|unclassified Bacteria	2|Bacteria	S	Methyltransferase domain	yrrM	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
CMS2_k127_256390_33	1379698.RBG1_1C00001G0560	5.924e-81	278.0	COG0483@1|root,COG0483@2|Bacteria,2NP94@2323|unclassified Bacteria	2|Bacteria	G	Inositol monophosphatase	suhB	GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25,3.1.3.7	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	M00131	R00188,R00508,R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Inositol_P
CMS2_k127_256390_0	635013.TherJR_0822	0.0	1675.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,260FM@186807|Peptococcaceae	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
CMS2_k127_256390_17	1047013.AQSP01000130_gene1883	1.964e-118	394.0	COG2256@1|root,COG2256@2|Bacteria,2NNTG@2323|unclassified Bacteria	2|Bacteria	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
CMS2_k127_256390_38	1191523.MROS_1321	9.124e-74	257.0	COG1028@1|root,COG1028@2|Bacteria	1191523.MROS_1321|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_256390_16	1210884.HG799462_gene8899	9.138e-120	402.0	COG2382@1|root,COG2382@2|Bacteria,2J2KX@203682|Planctomycetes	203682|Planctomycetes	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS2_k127_256390_43	1173025.GEI7407_3297	5.058e-66	231.0	COG1515@1|root,COG1515@2|Bacteria,1G2HF@1117|Cyanobacteria,1H8TY@1150|Oscillatoriales	1117|Cyanobacteria	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
CMS2_k127_256390_29	545695.TREAZ_0940	1.955e-86	296.0	COG5660@1|root,2Z7TM@2|Bacteria,2JBFN@203691|Spirochaetes	203691|Spirochaetes	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
CMS2_k127_256390_40	1123274.KB899422_gene53	6.668e-71	253.0	COG1638@1|root,COG1638@2|Bacteria,2J5PX@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
CMS2_k127_256390_9	573413.Spirs_2249	1.043e-169	552.0	COG1593@1|root,COG3090@1|root,COG1593@2|Bacteria,COG3090@2|Bacteria,2J5NW@203691|Spirochaetes	203691|Spirochaetes	G	transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
CMS2_k127_256390_32	1232410.KI421418_gene2303	2.41e-81	282.0	COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,42NWG@68525|delta/epsilon subdivisions,2WKEU@28221|Deltaproteobacteria,43VRR@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
CMS2_k127_256390_4	1499967.BAYZ01000152_gene1394	1.044e-194	671.0	COG2373@1|root,COG2373@2|Bacteria,2NQA2@2323|unclassified Bacteria	2|Bacteria	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1,Thiol-ester_cl
CMS2_k127_256390_10	1047013.AQSP01000123_gene1546	2.034e-159	532.0	COG4953@1|root,COG4953@2|Bacteria,2NQMA@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-Binding Protein C-terminus Family	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
CMS2_k127_256390_57	1121920.AUAU01000005_gene1002	4.562e-39	161.0	2EEYB@1|root,338RQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_256390_74	926550.CLDAP_09260	5.346e-07	59.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,2G5QB@200795|Chloroflexi	200795|Chloroflexi	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
CMS2_k127_256390_28	1408473.JHXO01000001_gene2146	9.943e-89	306.0	COG1453@1|root,COG1453@2|Bacteria,4NJU2@976|Bacteroidetes,2G2UD@200643|Bacteroidia	976|Bacteroidetes	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
CMS2_k127_256390_49	1191523.MROS_1832	2.38e-49	183.0	COG0344@1|root,COG0344@2|Bacteria	2|Bacteria	I	acyl-phosphate glycerol-3-phosphate acyltransferase activity	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
CMS2_k127_256390_13	1519464.HY22_07610	1.489e-140	467.0	COG1461@1|root,COG1461@2|Bacteria	2|Bacteria	S	glycerone kinase activity	yfhG	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2,DegV
CMS2_k127_256390_58	1027273.GZ77_01420	2.476e-38	146.0	2DNW1@1|root,32ZFG@2|Bacteria,1NBSM@1224|Proteobacteria,1S8G5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_256390_20	1237149.C900_03446	4.095e-106	367.0	COG0249@1|root,COG0249@2|Bacteria,4NE6X@976|Bacteroidetes,47KGC@768503|Cytophagia	976|Bacteroidetes	L	PFAM DNA mismatch repair protein MutS	-	-	-	-	-	-	-	-	-	-	-	-	MutS_III,MutS_V
CMS2_k127_256390_44	706587.Desti_3968	1.828e-63	240.0	COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,42V17@68525|delta/epsilon subdivisions,2WRD3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_256390_30	1304885.AUEY01000004_gene1017	1.363e-82	284.0	COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,42MCJ@68525|delta/epsilon subdivisions,2WKQ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS2_k127_256390_1	1211813.CAPH01000006_gene1682	1.275e-289	906.0	COG3808@1|root,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,2FM7F@200643|Bacteroidia,22V18@171550|Rikenellaceae	976|Bacteroidetes	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase,OmpA
CMS2_k127_256390_23	1123517.JOMR01000001_gene1907	1.813e-97	327.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,4607J@72273|Thiotrichales	72273|Thiotrichales	F	phosphoribosylaminoimidazole-succinocarboxamide synthase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
CMS2_k127_256390_70	439235.Dalk_3649	4.475e-12	73.0	COG1286@1|root,COG1286@2|Bacteria,1RJE1@1224|Proteobacteria,42SCW@68525|delta/epsilon subdivisions,2WPNX@28221|Deltaproteobacteria,2MKBI@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
CMS2_k127_256390_3	1047013.AQSP01000132_gene1730	1.468e-238	749.0	COG0459@1|root,COG0459@2|Bacteria,2NNM6@2323|unclassified Bacteria	2|Bacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS2_k127_256390_61	391603.FBALC1_03532	5.567e-33	130.0	COG1917@1|root,COG1917@2|Bacteria,4NRR5@976|Bacteroidetes,1I3Q8@117743|Flavobacteriia	976|Bacteroidetes	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS2_k127_256390_41	316067.Geob_3013	6.909e-70	245.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WN4E@28221|Deltaproteobacteria,43THN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
CMS2_k127_256390_8	289376.THEYE_A0518	5.21e-180	574.0	COG0863@1|root,COG1525@1|root,COG0863@2|Bacteria,COG1525@2|Bacteria	2|Bacteria	L	nuclease	-	-	2.1.1.113,3.1.31.1	ko:K00590,ko:K01174,ko:K02027	-	M00207	-	-	ko00000,ko00002,ko01000,ko02000,ko02048	3.A.1.1	-	-	Excalibur,N6_N4_Mtase,SNase
CMS2_k127_256390_21	1121403.AUCV01000020_gene3110	1.752e-105	351.0	COG1244@1|root,COG1244@2|Bacteria	2|Bacteria	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_256390_63	933262.AXAM01000003_gene2831	9.375e-29	131.0	COG2108@1|root,COG2108@2|Bacteria,1MY1Y@1224|Proteobacteria,42MIQ@68525|delta/epsilon subdivisions,2WJD2@28221|Deltaproteobacteria,2MHQT@213118|Desulfobacterales	28221|Deltaproteobacteria	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
CMS2_k127_256390_72	1047013.AQSP01000068_gene2281	1.378e-08	67.0	28WP9@1|root,2ZINZ@2|Bacteria	1047013.AQSP01000068_gene2281|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_256390_59	1354300.AUQY01000002_gene1254	4.295e-34	137.0	COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,24HG2@186801|Clostridia,22HEC@1570339|Peptoniphilaceae	186801|Clostridia	H	Molybdenum cofactor synthesis domain protein	mog	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
CMS2_k127_256390_51	941824.TCEL_00573	1.165e-46	172.0	COG0315@1|root,COG2258@1|root,COG0315@2|Bacteria,COG2258@2|Bacteria,1V3J4@1239|Firmicutes,24H9F@186801|Clostridia,36J0W@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
CMS2_k127_256390_50	1289135.A966_11272	1.26e-47	175.0	COG0315@1|root,COG0315@2|Bacteria,2J81J@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
CMS2_k127_256390_48	429009.Adeg_1590	1.726e-52	195.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia,42ES4@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
CMS2_k127_256390_24	1408473.JHXO01000010_gene3618	3.043e-95	325.0	COG0303@1|root,COG0303@2|Bacteria,4NDYD@976|Bacteroidetes	976|Bacteroidetes	H	Molybdenum cofactor synthesis domain	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
CMS2_k127_256390_27	195522.BD01_1602	4.723e-89	304.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7MN@28890|Euryarchaeota,245BN@183968|Thermococci	183968|Thermococci	E	TOBE domain	-	-	3.6.3.55	ko:K15497	ko02010,map02010	M00423	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.5	-	-	ABC_tran,TOBE
CMS2_k127_256390_36	525898.Sdel_2056	8.426e-76	262.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,42PIX@68525|delta/epsilon subdivisions,2YN2I@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K15496	ko02010,map02010	M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5	-	-	BPD_transp_1
CMS2_k127_256390_18	574087.Acear_1349	6.756e-110	364.0	COG0725@1|root,COG0725@2|Bacteria,1V2FD@1239|Firmicutes,24CFB@186801|Clostridia	186801|Clostridia	P	TIGRFAM tungstate ABC transporter binding protein WtpA	-	-	-	ko:K15495	ko02010,map02010	M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5	-	-	SBP_bac_11
CMS2_k127_256390_12	247490.KSU1_C0907	1.94e-142	484.0	COG0644@1|root,COG0644@2|Bacteria,2J1WS@203682|Planctomycetes	203682|Planctomycetes	C	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_256390_34	1499967.BAYZ01000039_gene2214	2.652e-79	275.0	2CEJC@1|root,32R1S@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_256390_6	1499967.BAYZ01000039_gene2211	8.244e-192	609.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	pqqE	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS2_k127_256390_22	1499967.BAYZ01000039_gene2210	4.12e-98	340.0	COG1512@1|root,COG1512@2|Bacteria	2|Bacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
CMS2_k127_256390_76	545693.BMQ_3824	0.0003865	49.0	2DN8M@1|root,32W40@2|Bacteria,1UPVD@1239|Firmicutes,4IVBM@91061|Bacilli,1ZSK9@1386|Bacillus	91061|Bacilli	S	YcxB-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YcxB
CMS2_k127_256390_2	1047013.AQSP01000120_gene942	1.624e-252	803.0	COG2217@1|root,COG2217@2|Bacteria,2NNPJ@2323|unclassified Bacteria	2|Bacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
CMS2_k127_256390_67	439235.Dalk_3004	3.206e-16	80.0	COG2608@1|root,COG2608@2|Bacteria,1PUDD@1224|Proteobacteria,42XJ7@68525|delta/epsilon subdivisions,2WSKI@28221|Deltaproteobacteria,2MP4U@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Heavy-metal-associated domain	-	-	-	-	-	-	-	-	-	-	-	-	HMA
CMS2_k127_256390_31	1191523.MROS_0663	2.118e-81	280.0	COG3358@1|root,COG3358@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
CMS2_k127_256390_75	204669.Acid345_3561	0.000228	54.0	COG2304@1|root,COG2304@2|Bacteria,3Y3QQ@57723|Acidobacteria,2JHV1@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
CMS2_k127_256390_14	283942.IL2339	3.645e-135	467.0	COG1629@1|root,COG4771@2|Bacteria,1MW4X@1224|Proteobacteria,1RPVY@1236|Gammaproteobacteria,2QGC4@267893|Idiomarinaceae	1236|Gammaproteobacteria	P	Outer membrane receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
CMS2_k127_256390_56	1047013.AQSP01000123_gene1524	1.514e-39	158.0	COG0457@1|root,COG0457@2|Bacteria	1047013.AQSP01000123_gene1524|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_256390_26	1232437.KL662020_gene704	1.118e-89	317.0	COG3591@1|root,COG5640@1|root,COG3591@2|Bacteria,COG5640@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,PKD,PPC,Trypsin,Trypsin_2
CMS2_k127_256390_55	1408473.JHXO01000002_gene3903	9.477e-44	169.0	COG3884@1|root,COG3884@2|Bacteria,4NMMY@976|Bacteroidetes,2FQ43@200643|Bacteroidia	976|Bacteroidetes	I	Acyl-ACP thioesterase	-	-	3.1.2.21	ko:K01071	ko00061,ko01100,map00061,map01100	-	R04014,R08157,R08158	RC00014,RC00039	ko00000,ko00001,ko01000,ko01004	-	-	-	Acyl-ACP_TE
CMS2_k127_256390_45	1122222.AXWR01000038_gene479	9.146e-63	221.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
CMS2_k127_256390_66	243274.THEMA_08420	5.115e-21	107.0	COG1453@1|root,COG1453@2|Bacteria,2GC54@200918|Thermotogae	200918|Thermotogae	C	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
CMS2_k127_256390_47	485916.Dtox_1134	7.486e-55	199.0	COG0224@1|root,COG0224@2|Bacteria,1UJD7@1239|Firmicutes,25G17@186801|Clostridia	186801|Clostridia	C	WbqC-like protein family	-	-	-	-	-	-	-	-	-	-	-	-	WbqC
CMS2_k127_256390_65	1123376.AUIU01000015_gene491	2.992e-25	113.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS2_k127_256390_35	999419.HMPREF1077_03658	1.517e-77	265.0	COG2120@1|root,COG2120@2|Bacteria,4NN16@976|Bacteroidetes,2FW3I@200643|Bacteroidia,22Z1Z@171551|Porphyromonadaceae	976|Bacteroidetes	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS2_k127_256390_68	944547.ABLL_2440	5.211e-14	74.0	COG1942@1|root,COG1942@2|Bacteria,1N7K1@1224|Proteobacteria	1224|Proteobacteria	S	4-oxalocrotonate tautomerase	nahJ	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
CMS2_k127_256390_39	1379698.RBG1_1C00001G1218	1.02e-72	277.0	COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria	2|Bacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_8
CMS2_k127_256390_53	177437.HRM2_05530	5.491e-45	170.0	COG1468@1|root,COG1468@2|Bacteria,1RH80@1224|Proteobacteria,42T7D@68525|delta/epsilon subdivisions,2WPJ2@28221|Deltaproteobacteria,2MNI0@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Domain of unknown function DUF83	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
CMS2_k127_256390_64	373903.Hore_15200	9.198e-27	112.0	COG1343@1|root,COG1343@2|Bacteria,1VDQA@1239|Firmicutes,24Q2T@186801|Clostridia,3WASE@53433|Halanaerobiales	186801|Clostridia	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	cas2	-	-	ko:K09951	-	-	-	-	ko00000,ko02048	-	-	-	CRISPR_Cas2
CMS2_k127_256390_25	765913.ThidrDRAFT_1105	4.852e-90	307.0	COG1518@1|root,COG1518@2|Bacteria,1MUKK@1224|Proteobacteria,1RNYK@1236|Gammaproteobacteria,1WWHK@135613|Chromatiales	135613|Chromatiales	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	-	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1
CMS2_k127_256390_7	926692.AZYG01000070_gene1690	6.072e-186	610.0	COG1203@1|root,COG1203@2|Bacteria,1TQ9B@1239|Firmicutes,248UE@186801|Clostridia,3WAH6@53433|Halanaerobiales	186801|Clostridia	L	DEAD-like helicases superfamily	-	-	-	ko:K07012	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DEAD,HD,Helicase_C,ResIII
CMS2_k127_256390_54	459349.CLOAM1292	8.673e-45	172.0	COG1688@1|root,COG1688@2|Bacteria,2NS30@2323|unclassified Bacteria	2|Bacteria	L	CRISPR-associated protein (Cas_Cas5)	cas5h	-	-	ko:K19116	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Cas5d
CMS2_k127_256390_69	373903.Hore_15240	3.26e-13	73.0	COG3649@1|root,COG3649@2|Bacteria,1TQZ8@1239|Firmicutes,248MT@186801|Clostridia,3WAQV@53433|Halanaerobiales	186801|Clostridia	L	CRISPR-associated protein Cas7	-	-	-	ko:K19115	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Cas7
CMS2_k127_2574442_2	1047013.AQSP01000133_gene2111	1.863e-176	581.0	COG0178@1|root,COG0178@2|Bacteria,2NQR8@2323|unclassified Bacteria	2|Bacteria	L	ABC transporter	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS2_k127_2574442_17	1158318.ATXC01000001_gene116	6.54e-10	62.0	COG5336@1|root,COG5336@2|Bacteria	2|Bacteria	C	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
CMS2_k127_2574442_7	1047013.AQSP01000119_gene1285	2.168e-69	243.0	COG0356@1|root,COG0356@2|Bacteria,2NPRQ@2323|unclassified Bacteria	2|Bacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
CMS2_k127_2574442_15	502025.Hoch_4471	2.011e-11	68.0	COG0636@1|root,COG0636@2|Bacteria,1QAIF@1224|Proteobacteria,43A8Y@68525|delta/epsilon subdivisions,2X9Z1@28221|Deltaproteobacteria,2YW38@29|Myxococcales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
CMS2_k127_2574442_9	1047013.AQSP01000119_gene1287	7.417e-38	155.0	COG1295@1|root,COG1295@2|Bacteria	2|Bacteria	S	lipopolysaccharide transmembrane transporter activity	yfkH	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
CMS2_k127_2574442_6	1047013.AQSP01000119_gene1288	7.211e-74	260.0	COG1044@1|root,COG1044@2|Bacteria,2NNSF@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	ic_1306.c0216	Hexapep,Hexapep_2,LpxD
CMS2_k127_2574442_1	1123274.KB899409_gene603	2.107e-197	636.0	COG0272@1|root,COG0272@2|Bacteria,2J57Q@203691|Spirochaetes	203691|Spirochaetes	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
CMS2_k127_2574442_5	1121434.AULY01000007_gene1401	3.162e-85	292.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,42PGP@68525|delta/epsilon subdivisions,2WMGP@28221|Deltaproteobacteria,2M84A@213115|Desulfovibrionales	28221|Deltaproteobacteria	KQ	PFAM Methyltransferase type 11	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5,Methyltransf_11
CMS2_k127_2574442_0	56780.SYN_00416	5.374e-240	749.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2MR55@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
CMS2_k127_2574442_10	706587.Desti_1483	1.172e-28	126.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,42TUJ@68525|delta/epsilon subdivisions,2WQ4U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	phosphotransferase related to Ser Thr protein kinases	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
CMS2_k127_2574442_8	1121438.JNJA01000044_gene102	1.348e-50	184.0	COG3600@1|root,COG3600@2|Bacteria,1Q99T@1224|Proteobacteria,4349S@68525|delta/epsilon subdivisions,2X1AI@28221|Deltaproteobacteria,2MEMV@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF4065)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4065
CMS2_k127_2574442_12	1137268.AZXF01000014_gene78	4.677e-17	87.0	2EJIH@1|root,33D9E@2|Bacteria,2GVQK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2574442_3	1385519.N801_17725	2.422e-145	505.0	COG1404@1|root,COG1404@2|Bacteria,2IFQ2@201174|Actinobacteria	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS2_k127_2574442_14	391625.PPSIR1_12748	3.113e-14	79.0	2ET0W@1|root,33KJ4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2574442_4	237368.SCABRO_01228	8.142e-130	422.0	COG0180@1|root,COG0180@2|Bacteria,2IWRB@203682|Planctomycetes	203682|Planctomycetes	J	Tryptophanyl-tRNA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_1b
CMS2_k127_2585483_3	768670.Calni_0564	5.452e-219	690.0	COG4799@1|root,COG4799@2|Bacteria,2GEP0@200930|Deferribacteres	200930|Deferribacteres	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
CMS2_k127_2585483_1	755731.Clo1100_0890	0.0	1497.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2585483_2	509191.AEDB02000085_gene2708	0.0	1131.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2585483_4	509191.AEDB02000067_gene916	6.543e-197	628.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_2585483_0	1121121.KB894307_gene2066	0.0	3686.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2585483_5	489825.LYNGBM3L_58270	8.032e-111	411.0	COG3319@1|root,COG3321@1|root,COG3319@2|Bacteria,COG3321@2|Bacteria,1GCBM@1117|Cyanobacteria,1HF3E@1150|Oscillatoriales	1117|Cyanobacteria	Q	Acyl transferase domain in polyketide synthase (PKS) enzymes.	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,PP-binding,Thioesterase
CMS2_k127_2585483_6	67257.JODR01000074_gene28	0.0002336	46.0	2EGYK@1|root,3493T@2|Bacteria,2GRY2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2610636_0	649747.HMPREF0083_00279	1.883e-205	667.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16123,ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2613716_27	41431.PCC8801_0753	1.868e-05	55.0	COG1413@1|root,COG1413@2|Bacteria,1G233@1117|Cyanobacteria	1117|Cyanobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Metallophos,NACHT,NB-ARC,Peptidase_C14,Trypsin_2
CMS2_k127_2613716_1	1499967.BAYZ01000102_gene3561	0.0	1068.0	COG4262@1|root,COG4262@2|Bacteria,2NS3W@2323|unclassified Bacteria	2|Bacteria	S	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_1,Spermine_synth
CMS2_k127_2613716_6	1191523.MROS_0148	4.325e-138	449.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2	-	-	MtrB_PioB,OMP_b-brl,OMP_b-brl_2
CMS2_k127_2613716_2	945713.IALB_0266	1.819e-225	705.0	COG4885@1|root,COG4885@2|Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT,Cytochrome_C554
CMS2_k127_2613716_25	502025.Hoch_3130	1.009e-07	62.0	2E7B7@1|root,331UM@2|Bacteria,1NB58@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2613716_21	1288.SXYLSMQ121_2003	1.364e-22	102.0	COG1661@1|root,COG1661@2|Bacteria,1VJ30@1239|Firmicutes,4HNJK@91061|Bacilli,4GZ2A@90964|Staphylococcaceae	91061|Bacilli	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
CMS2_k127_2613716_5	1047013.AQSP01000144_gene930	1.101e-151	509.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,2NNXM@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,DUF3365,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg
CMS2_k127_2613716_19	1304875.JAFZ01000004_gene471	6.084e-31	124.0	COG0011@1|root,COG0011@2|Bacteria,3TBE4@508458|Synergistetes	508458|Synergistetes	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
CMS2_k127_2613716_3	1313301.AUGC01000006_gene3	9.835e-223	713.0	COG2183@1|root,COG2183@2|Bacteria,4NETD@976|Bacteroidetes	976|Bacteroidetes	K	Tex-like protein N-terminal domain	yhgF	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
CMS2_k127_2613716_8	1047013.AQSP01000128_gene428	3.283e-123	410.0	COG1030@1|root,COG1030@2|Bacteria,2NNMU@2323|unclassified Bacteria	2|Bacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
CMS2_k127_2613716_10	1047013.AQSP01000128_gene429	8.101e-100	331.0	COG0330@1|root,COG0330@2|Bacteria,2NNUC@2323|unclassified Bacteria	2|Bacteria	O	prohibitin homologues	hflC	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS2_k127_2613716_23	1047013.AQSP01000128_gene430	1.782e-08	63.0	COG3147@1|root,COG3147@2|Bacteria	2|Bacteria	S	peptidoglycan binding	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
CMS2_k127_2613716_12	1047013.AQSP01000128_gene431	3.656e-76	274.0	COG0815@1|root,COG0815@2|Bacteria,2NP0R@2323|unclassified Bacteria	2|Bacteria	M	Carbon-nitrogen hydrolase	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
CMS2_k127_2613716_11	933262.AXAM01000094_gene2196	5.049e-81	285.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,42P7C@68525|delta/epsilon subdivisions,2WKKF@28221|Deltaproteobacteria,2MIJE@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM MltA	-	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
CMS2_k127_2613716_18	5180.EDN94244	8.21e-35	153.0	KOG0266@1|root,KOG0272@1|root,KOG0266@2759|Eukaryota,KOG0272@2759|Eukaryota,38B6D@33154|Opisthokonta,3NYUK@4751|Fungi,3QKYQ@4890|Ascomycota	4751|Fungi	U	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,NACHT_N,WD40
CMS2_k127_2613716_4	1047013.AQSP01000093_gene11	1.214e-201	632.0	COG0520@1|root,COG0520@2|Bacteria,2NNS0@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
CMS2_k127_2613716_9	880073.Calab_1356	5.369e-118	399.0	COG1305@1|root,COG1305@2|Bacteria,2NQ2D@2323|unclassified Bacteria	2|Bacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	TIG,Transglut_core
CMS2_k127_2613716_7	457396.CSBG_03188	9.248e-132	435.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,36DRC@31979|Clostridiaceae	186801|Clostridia	C	FAD linked oxidase domain protein	glcD1	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
CMS2_k127_2613716_28	926569.ANT_14000	6.342e-05	55.0	COG1933@1|root,COG1933@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease I activity	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,PLDc_N,zf-ribbon_3,zinc_ribbon_2
CMS2_k127_2613716_26	929713.NIASO_07465	4.675e-06	49.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,1IQ0T@117747|Sphingobacteriia	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_2613716_22	1121481.AUAS01000017_gene2480	4.429e-18	89.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47JJN@768503|Cytophagia	976|Bacteroidetes	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_2613716_15	316067.Geob_0985	1.714e-41	157.0	COG3467@1|root,COG3467@2|Bacteria,1N4RH@1224|Proteobacteria,42TKQ@68525|delta/epsilon subdivisions,2WQ06@28221|Deltaproteobacteria,43VAD@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
CMS2_k127_2613716_24	1379698.RBG1_1C00001G0705	3.717e-08	64.0	COG0760@1|root,COG0760@2|Bacteria,2NPFB@2323|unclassified Bacteria	2|Bacteria	O	PPIC-type PPIASE domain	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N_3
CMS2_k127_2613716_17	1047013.AQSP01000132_gene1713	1.955e-36	151.0	COG0760@1|root,COG0760@2|Bacteria,2NPFB@2323|unclassified Bacteria	2|Bacteria	O	PPIC-type PPIASE domain	ppiD	-	5.2.1.8	ko:K03769,ko:K03770,ko:K03771,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3
CMS2_k127_2613716_16	1117108.PAALTS15_08139	1.624e-39	156.0	COG0500@1|root,COG2226@2|Bacteria,1V45D@1239|Firmicutes,4HG4Y@91061|Bacilli,274IB@186822|Paenibacillaceae	91061|Bacilli	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS2_k127_2613716_14	118173.KB235914_gene3650	9.059e-57	209.0	COG0564@1|root,COG0564@2|Bacteria,1G0FD@1117|Cyanobacteria,1H7TQ@1150|Oscillatoriales	1117|Cyanobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS2_k127_2613716_13	1047013.AQSP01000125_gene2644	4.587e-70	246.0	COG0682@1|root,COG0682@2|Bacteria,2NPK2@2323|unclassified Bacteria	2|Bacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CMS2_k127_2613716_20	639282.DEFDS_1186	3.147e-26	113.0	COG0597@1|root,COG0597@2|Bacteria,2GFR7@200930|Deferribacteres	200930|Deferribacteres	M	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
CMS2_k127_2613716_0	1047013.AQSP01000125_gene2646	0.0	1069.0	COG0060@1|root,COG0060@2|Bacteria,2NNT5@2323|unclassified Bacteria	2|Bacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_0027,iPC815.YPO0475	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
CMS2_k127_2614914_0	313628.LNTAR_04896	1.488e-47	186.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
CMS2_k127_2614914_1	870187.Thini_0061	1.042e-26	111.0	COG1487@1|root,COG1487@2|Bacteria,1RIB5@1224|Proteobacteria,1S4KB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
CMS2_k127_262826_4	1380354.JIAN01000005_gene1924	3.069e-55	216.0	COG1376@1|root,COG1376@2|Bacteria	2|Bacteria	D	ErfK ybiS ycfS ynhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,YkuD
CMS2_k127_262826_13	1408444.JHYC01000002_gene564	2.046e-09	64.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1JEI4@118969|Legionellales	118969|Legionellales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
CMS2_k127_262826_1	880073.Calab_0231	9.342e-225	706.0	COG0055@1|root,COG0055@2|Bacteria,2NNRB@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658	ATP-synt_ab,ATP-synt_ab_N
CMS2_k127_262826_5	1121430.JMLG01000002_gene1218	1.996e-51	193.0	COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia,2601T@186807|Peptococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
CMS2_k127_262826_0	1047013.AQSP01000132_gene1701	1.033e-225	708.0	COG0056@1|root,COG0056@2|Bacteria,2NP0S@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016469,GO:0030312,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	iSB619.SA_RS10975	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
CMS2_k127_262826_11	518637.EUBIFOR_00973	3.299e-11	71.0	COG0712@1|root,COG0712@2|Bacteria,1TTVT@1239|Firmicutes,3VRS0@526524|Erysipelotrichia	526524|Erysipelotrichia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	-	-	-	-	-	-	-	-	-	OSCP
CMS2_k127_262826_12	1047013.AQSP01000132_gene1699	4.941e-11	71.0	COG0711@1|root,COG0711@2|Bacteria	2|Bacteria	C	ATP synthesis coupled proton transport	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02109,ko:K18682	ko00190,ko00195,ko01100,ko03018,map00190,map00195,map01100,map03018	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000,ko03019	3.A.2.1	-	-	ATP-synt_B
CMS2_k127_262826_15	204536.SULAZ_0455	0.0001412	49.0	COG0711@1|root,COG0711@2|Bacteria,2G4B3@200783|Aquificae	200783|Aquificae	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
CMS2_k127_262826_9	931276.Cspa_c54040	4.888e-19	101.0	COG1672@1|root,COG1672@2|Bacteria,1TPQR@1239|Firmicutes,24AIK@186801|Clostridia,36FFJ@31979|Clostridiaceae	186801|Clostridia	S	PFAM Archaeal ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,AAA_35,PDDEXK_3
CMS2_k127_262826_14	926550.CLDAP_31790	4.088e-09	70.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	AAA_22
CMS2_k127_262826_2	1047013.AQSP01000121_gene2694	6.353e-95	334.0	COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_262826_7	1122225.AULQ01000002_gene701	3.795e-28	132.0	2DEPS@1|root,2ZNRS@2|Bacteria,4P8E6@976|Bacteroidetes,1IB88@117743|Flavobacteriia	1122225.AULQ01000002_gene701|-	S	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_262826_3	309799.DICTH_0438	4.227e-65	250.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	wblG	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_262826_8	1121481.AUAS01000027_gene2807	1.45e-19	94.0	2DB8U@1|root,2Z7SW@2|Bacteria,4NEUK@976|Bacteroidetes,47KH1@768503|Cytophagia	976|Bacteroidetes	S	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase
CMS2_k127_263433_0	358681.BBR47_27890	0.0	2055.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_263433_1	163908.KB235896_gene3938	4.519e-76	269.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_2654358_13	309803.CTN_1726	4.46e-06	57.0	COG0484@1|root,COG0484@2|Bacteria,2GC14@200918|Thermotogae	200918|Thermotogae	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
CMS2_k127_2654358_5	1408473.JHXO01000007_gene899	3.76e-126	419.0	COG0527@1|root,COG0527@2|Bacteria,4PKFA@976|Bacteroidetes,2G3F2@200643|Bacteroidia	976|Bacteroidetes	E	Amino acid kinase family	-	-	1.1.1.3,2.7.2.4	ko:K00928,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
CMS2_k127_2654358_8	1382306.JNIM01000001_gene3144	3.542e-31	125.0	COG1324@1|root,COG1324@2|Bacteria,2G76K@200795|Chloroflexi	200795|Chloroflexi	P	CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
CMS2_k127_2654358_6	1201290.M902_2695	7.916e-66	233.0	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,42S4C@68525|delta/epsilon subdivisions,2MT2B@213481|Bdellovibrionales,2WNXY@28221|Deltaproteobacteria	213481|Bdellovibrionales	I	enoyl-CoA hydratase isomerase family protein	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS2_k127_2654358_1	1121405.dsmv_2932	1.729e-171	545.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MIA8@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS2_k127_2654358_10	391625.PPSIR1_27073	1.19e-20	99.0	COG0511@1|root,COG0511@2|Bacteria	2|Bacteria	I	ligase activity, forming carbon-carbon bonds	-	-	2.3.1.12,2.3.1.39	ko:K00627,ko:K00645,ko:K02160	ko00010,ko00020,ko00061,ko00333,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00333,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00307,M00376	R00209,R00742,R01626,R02569,R11671	RC00004,RC00039,RC00040,RC00367,RC02727,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,Biotin_lipoyl_2,CPSase_L_D2
CMS2_k127_2654358_0	502025.Hoch_5456	1.202e-231	730.0	COG4799@1|root,COG4799@2|Bacteria,1Q9BU@1224|Proteobacteria,42P34@68525|delta/epsilon subdivisions,2WK9S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM carboxyl transferase	gcdA	-	4.1.1.70	ko:K01615	ko00362,ko00650,ko01120,map00362,map00650,map01120	-	R03028	RC00832	ko00000,ko00001,ko01000,ko02000	3.B.1.1.3	-	-	Carboxyl_trans
CMS2_k127_2654358_2	1033737.CAEV01000099_gene1710	1.476e-159	514.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,25E48@186801|Clostridia,36DJ8@31979|Clostridiaceae	186801|Clostridia	I	acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
CMS2_k127_2654358_7	573064.Mefer_1486	5.539e-38	146.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,23QWX@183939|Methanococci	183939|Methanococci	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
CMS2_k127_2654358_4	1041930.Mtc_2447	1.319e-133	437.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
CMS2_k127_2654358_3	523845.AQXV01000053_gene747	6.203e-135	440.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,23Q7Q@183939|Methanococci	183939|Methanococci	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
CMS2_k127_2654358_9	338966.Ppro_0378	1.577e-30	125.0	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42NMK@68525|delta/epsilon subdivisions,2WK6K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_2654358_14	709991.Odosp_0540	0.0006693	43.0	COG5464@1|root,COG5464@2|Bacteria,4NHKS@976|Bacteroidetes,2FPNY@200643|Bacteroidia,22XCI@171551|Porphyromonadaceae	976|Bacteroidetes	S	PD-(D/E)XK nuclease family transposase	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_2654358_11	573413.Spirs_3467	3.815e-16	79.0	COG2161@1|root,COG2161@2|Bacteria,2J8SD@203691|Spirochaetes	203691|Spirochaetes	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
CMS2_k127_2654358_12	452637.Oter_2296	3.669e-14	81.0	COG5635@1|root,COG5635@2|Bacteria	2|Bacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2654862_0	509191.AEDB02000067_gene916	4.998e-182	585.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_2660576_26	760117.JN27_14910	1.964e-06	62.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,2VPSX@28216|Betaproteobacteria,47600@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	GvpD gas vesicle protein	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
CMS2_k127_2660576_24	1284352.AOIG01000039_gene3002	2.065e-15	91.0	COG0467@1|root,COG0467@2|Bacteria,1TSIM@1239|Firmicutes,4HTG9@91061|Bacilli,271V4@186822|Paenibacillaceae	91061|Bacilli	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
CMS2_k127_2660576_1	1237149.C900_01682	0.0	1587.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,4NDV5@976|Bacteroidetes,47K9U@768503|Cytophagia	976|Bacteroidetes	Q	Acyl transferase domain in polyketide synthase (PKS) enzymes.	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2660576_0	509191.AEDB02000085_gene2708	0.0	1874.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2660576_7	313606.M23134_07246	8.304e-126	437.0	COG2203@1|root,COG2208@1|root,COG3292@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3292@2|Bacteria,4NKGA@976|Bacteroidetes,47TQU@768503|Cytophagia	976|Bacteroidetes	T	Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,SpoIIE,Y_Y_Y
CMS2_k127_2660576_25	313596.RB2501_03335	3.294e-10	74.0	COG2207@1|root,COG2207@2|Bacteria,4NPYN@976|Bacteroidetes,1I2A4@117743|Flavobacteriia	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Reg_prop,Y_Y_Y
CMS2_k127_2660576_6	247490.KSU1_C0714	2.924e-144	505.0	COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes	203682|Planctomycetes	O	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
CMS2_k127_2660576_19	1121403.AUCV01000012_gene4109	4.847e-31	143.0	COG1075@1|root,COG1075@2|Bacteria,1QD4I@1224|Proteobacteria,435MR@68525|delta/epsilon subdivisions,2X9BC@28221|Deltaproteobacteria,2MNSY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2660576_9	439235.Dalk_0237	1.065e-99	367.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_2660576_15	880073.Calab_0132	5.022e-61	226.0	COG3049@1|root,COG3049@2|Bacteria,2NQGK@2323|unclassified Bacteria	2|Bacteria	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	AAT,CBAH
CMS2_k127_2660576_3	1047013.AQSP01000132_gene1712	2.478e-187	624.0	COG1197@1|root,COG1197@2|Bacteria,2NNMM@2323|unclassified Bacteria	2|Bacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
CMS2_k127_2660576_12	1121920.AUAU01000025_gene2333	6.489e-71	250.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
CMS2_k127_2660576_11	1158318.ATXC01000001_gene844	1.55e-90	305.0	COG0294@1|root,COG0294@2|Bacteria,2G3IT@200783|Aquificae	200783|Aquificae	H	dihydropteroate synthase	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CMS2_k127_2660576_22	1202532.FF52_10643	1.753e-18	94.0	COG0457@1|root,COG3103@1|root,COG0457@2|Bacteria,COG3103@2|Bacteria,4NF5V@976|Bacteroidetes,1HYKU@117743|Flavobacteriia,2NU4E@237|Flavobacterium	976|Bacteroidetes	T	BatE protein	batE	-	-	-	-	-	-	-	-	-	-	-	SH3_3,SH3_4,TPR_1,TPR_11,TPR_16,TPR_2
CMS2_k127_2660576_20	1158294.JOMI01000007_gene328	3.899e-30	138.0	COG0457@1|root,COG0457@2|Bacteria,4NERG@976|Bacteroidetes,2FMK5@200643|Bacteroidia	976|Bacteroidetes	T	Tetratricopeptide repeat protein	batD	-	-	-	-	-	-	-	-	-	-	-	BatD,TPR_2
CMS2_k127_2660576_17	237368.SCABRO_01883	1.323e-55	207.0	COG2304@1|root,COG2304@2|Bacteria,2IYZ1@203682|Planctomycetes	203682|Planctomycetes	A	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
CMS2_k127_2660576_18	545243.BAEV01000043_gene1581	1.124e-49	184.0	COG2068@1|root,COG2068@2|Bacteria,1UY6E@1239|Firmicutes,249PV@186801|Clostridia,36FU4@31979|Clostridiaceae	186801|Clostridia	S	MobA-like NTP transferase domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS2_k127_2660576_2	518766.Rmar_0330	1.054e-257	829.0	COG1629@1|root,COG4771@2|Bacteria,4NF66@976|Bacteroidetes,1FIX1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
CMS2_k127_2660576_27	1047013.AQSP01000068_gene2281	4.147e-06	59.0	28WP9@1|root,2ZINZ@2|Bacteria	1047013.AQSP01000068_gene2281|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2660576_21	74547.PMT_0296	2.488e-20	97.0	COG0457@1|root,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1MM8U@1212|Prochloraceae	1117|Cyanobacteria	O	Alternative locus ID	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_8
CMS2_k127_2660576_4	309799.DICTH_0538	1.966e-156	504.0	COG0156@1|root,COG0156@2|Bacteria	2|Bacteria	E	8-amino-7-oxononanoate synthase activity	bioF	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_2660576_8	5932.XP_004034681.1	1.511e-100	334.0	COG0005@1|root,KOG3984@2759|Eukaryota,3ZDBS@5878|Ciliophora	5878|Ciliophora	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	PNP_UDP_1
CMS2_k127_2660576_5	273068.TTE0463	1.783e-144	468.0	COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,42F24@68295|Thermoanaerobacterales	186801|Clostridia	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
CMS2_k127_2660576_14	1131269.AQVV01000070_gene1533	6.482e-64	230.0	COG1533@1|root,COG1533@2|Bacteria	2|Bacteria	L	DNA photolyase activity	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
CMS2_k127_2660576_23	637905.SVI_3430	4.786e-16	89.0	COG3595@1|root,COG3595@2|Bacteria,1P19T@1224|Proteobacteria,1RRSR@1236|Gammaproteobacteria,2Q9SH@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS2_k127_2660576_13	1121904.ARBP01000001_gene5465	6.906e-69	247.0	COG3595@1|root,COG3595@2|Bacteria,4NJCC@976|Bacteroidetes,47MIA@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS2_k127_2660576_10	439235.Dalk_0237	1.84e-99	356.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_2660576_16	694427.Palpr_2226	6.404e-61	238.0	COG3656@1|root,COG3656@2|Bacteria,4NHDQ@976|Bacteroidetes,2FTSH@200643|Bacteroidia,22Y91@171551|Porphyromonadaceae	976|Bacteroidetes	S	Fibronectin type 3 domain	-	-	-	ko:K21571	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_266642_2	105559.Nwat_2867	3.356e-06	49.0	COG4226@1|root,COG4226@2|Bacteria,1MZE7@1224|Proteobacteria,1S99M@1236|Gammaproteobacteria,1X1D3@135613|Chromatiales	135613|Chromatiales	S	HicB family	-	-	-	-	-	-	-	-	-	-	-	-	HicB
CMS2_k127_266642_0	1174528.JH992892_gene6257	4.723e-20	91.0	2C1FP@1|root,32YNH@2|Bacteria,1GKJS@1117|Cyanobacteria,1JMCE@1189|Stigonemataceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_266642_1	1121935.AQXX01000089_gene4699	5.859e-14	76.0	COG3209@1|root,COG3209@2|Bacteria,1RJSQ@1224|Proteobacteria,1S7V3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2726578_0	1167006.UWK_01458	3.949e-105	351.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,2MPYE@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS2_k127_2817469_19	439235.Dalk_1290	4.991e-46	177.0	28K3K@1|root,2Z9SQ@2|Bacteria,1R8H5@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2817469_25	1237149.C900_01567	6.829e-29	135.0	COG0457@1|root,COG2208@1|root,COG0457@2|Bacteria,COG2208@2|Bacteria,4NUFW@976|Bacteroidetes	976|Bacteroidetes	KT	COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,TPR_12
CMS2_k127_2817469_17	1499967.BAYZ01000111_gene2945	2.095e-46	192.0	COG3899@1|root,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Trans_reg_C
CMS2_k127_2817469_15	1047013.AQSP01000139_gene2329	8.968e-60	217.0	COG2091@1|root,COG2091@2|Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_2817469_6	1408473.JHXO01000001_gene2283	2.617e-92	311.0	COG1108@1|root,COG1108@2|Bacteria,4NH3D@976|Bacteroidetes,2FNK0@200643|Bacteroidia	976|Bacteroidetes	P	ABC 3 transport family protein	znuB	-	-	ko:K02075,ko:K09816	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
CMS2_k127_2817469_10	1121129.KB903367_gene2837	1.616e-82	281.0	COG1121@1|root,COG1121@2|Bacteria,4NHZ9@976|Bacteroidetes,2FM2P@200643|Bacteroidia,22VV3@171551|Porphyromonadaceae	976|Bacteroidetes	P	ABC transporter, ATP-binding protein	znuC	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
CMS2_k127_2817469_11	1385935.N836_35710	1.004e-77	269.0	COG0803@1|root,COG0803@2|Bacteria,1G04M@1117|Cyanobacteria,1HEY8@1150|Oscillatoriales	1117|Cyanobacteria	P	Zinc-uptake complex component A periplasmic	zntC	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
CMS2_k127_2817469_20	1034807.FBFL15_0576	1.384e-36	144.0	COG5464@1|root,COG5464@2|Bacteria,4NGSI@976|Bacteroidetes,1IBPT@117743|Flavobacteriia	976|Bacteroidetes	S	to proteins from other organisms	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_2817469_14	335543.Sfum_2756	3.959e-65	255.0	COG0707@1|root,COG1413@1|root,COG0707@2|Bacteria,COG1413@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2WJNY@28221|Deltaproteobacteria,2MRPC@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
CMS2_k127_2817469_23	500633.CLOHIR_00973	7.632e-34	153.0	COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,25R0J@186804|Peptostreptococcaceae	186801|Clostridia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
CMS2_k127_2817469_7	335543.Sfum_2755	5.432e-92	314.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,42MCP@68525|delta/epsilon subdivisions,2WJDS@28221|Deltaproteobacteria,2MQC4@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iAF987.Gmet_0409	Glycos_transf_4,MraY_sig1
CMS2_k127_2817469_2	880073.Calab_1086	6.673e-123	406.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2NQE8@2323|unclassified Bacteria	2|Bacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	GAF,GAF_2,HD,HD_5
CMS2_k127_2817469_9	573370.DMR_35990	8.904e-86	307.0	COG1404@1|root,COG1404@2|Bacteria,1RC5K@1224|Proteobacteria,42U2I@68525|delta/epsilon subdivisions,2WQAT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS2_k127_2817469_1	1499967.BAYZ01000195_gene3106	1.87e-155	507.0	COG1807@1|root,COG1807@2|Bacteria,2NPZC@2323|unclassified Bacteria	2|Bacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	MA20_19960	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS2_k127_2817469_3	247490.KSU1_C0538	1.185e-114	376.0	COG1741@1|root,COG1741@2|Bacteria,2IXVU@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
CMS2_k127_2817469_13	649747.HMPREF0083_02925	4.824e-68	238.0	COG1794@1|root,COG1794@2|Bacteria,1TR3U@1239|Firmicutes,4IQXA@91061|Bacilli	91061|Bacilli	M	Belongs to the aspartate glutamate racemases family	racX	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
CMS2_k127_2817469_5	706587.Desti_3540	4.788e-93	313.0	COG1600@1|root,COG1600@2|Bacteria,1RAYI@1224|Proteobacteria,42R4W@68525|delta/epsilon subdivisions,2WK0B@28221|Deltaproteobacteria,2MSDE@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2817469_0	1499967.BAYZ01000130_gene2591	2.118e-215	681.0	COG1760@1|root,COG1760@2|Bacteria,2NQRY@2323|unclassified Bacteria	2|Bacteria	E	Serine dehydratase alpha chain	-	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
CMS2_k127_2817469_21	1178825.ALIH01000001_gene2432	7.697e-35	154.0	COG2204@1|root,COG3604@1|root,COG2204@2|Bacteria,COG3604@2|Bacteria,4NE89@976|Bacteroidetes,1I08N@117743|Flavobacteriia	976|Bacteroidetes	T	Fis family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HTH_8,PAS_3,PAS_9,Response_reg,Sigma54_activat
CMS2_k127_2817469_4	439235.Dalk_3656	6.766e-100	355.0	COG0591@1|root,COG3852@1|root,COG0591@2|Bacteria,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43CEX@68525|delta/epsilon subdivisions,2X7PW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HisKA,PAS
CMS2_k127_2817469_8	933262.AXAM01000027_gene2113	1.516e-91	319.0	COG1716@1|root,COG2304@1|root,COG1716@2|Bacteria,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K08777	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FHA,VWA
CMS2_k127_2817469_16	1343740.M271_40310	3.955e-56	215.0	COG0515@1|root,COG1716@1|root,COG0515@2|Bacteria,COG1716@2|Bacteria,2ICK6@201174|Actinobacteria	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FHA,Pkinase
CMS2_k127_2817469_28	237368.SCABRO_00880	1.924e-24	115.0	COG0535@1|root,COG0535@2|Bacteria,2IWZK@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS2_k127_2817469_18	136273.GY22_02315	3.88e-46	186.0	COG2192@1|root,COG2192@2|Bacteria,2GJHV@201174|Actinobacteria	201174|Actinobacteria	O	Carbamoyltransferase	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS2_k127_2817469_22	497964.CfE428DRAFT_0344	1.536e-34	143.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,SEFIR,TIR_2
CMS2_k127_2817469_26	635013.TherJR_2332	1.899e-26	124.0	COG1032@1|root,COG1032@2|Bacteria,1UZJU@1239|Firmicutes,24AV2@186801|Clostridia,264YB@186807|Peptococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_2817469_35	1211817.CCAT010000043_gene3447	6.549e-11	74.0	COG0641@1|root,COG0641@2|Bacteria,1V0HK@1239|Firmicutes,2497U@186801|Clostridia,36G2D@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S single cluster domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS2_k127_2817469_36	1291050.JAGE01000001_gene1432	7.993e-11	73.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	ko:K07011,ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS2_k127_2817469_24	985054.JQEZ01000001_gene1878	5.199e-31	136.0	COG0438@1|root,COG0438@2|Bacteria,1PERI@1224|Proteobacteria,2V82U@28211|Alphaproteobacteria,4NDJT@97050|Ruegeria	28211|Alphaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
CMS2_k127_2817469_30	497964.CfE428DRAFT_2583	1.653e-19	101.0	2DSWS@1|root,33HQW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2817469_31	1536773.R70331_07105	7.952e-17	92.0	COG0535@1|root,COG0535@2|Bacteria,1W6UW@1239|Firmicutes,4I6IK@91061|Bacilli,26T8B@186822|Paenibacillaceae	91061|Bacilli	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS2_k127_2817469_33	1279009.ADICEAN_01885	9.261e-12	76.0	COG0438@1|root,COG0438@2|Bacteria,4NJ0W@976|Bacteroidetes,47XDB@768503|Cytophagia	976|Bacteroidetes	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_2817469_29	1348114.OM33_05185	1.035e-19	100.0	COG0535@1|root,COG0535@2|Bacteria,1PEN5@1224|Proteobacteria,1SDT2@1236|Gammaproteobacteria,2Q3ED@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
CMS2_k127_2817469_27	1379698.RBG1_1C00001G1162	1.563e-24	113.0	COG0726@1|root,COG0726@2|Bacteria,2NPY1@2323|unclassified Bacteria	2|Bacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Polysacc_deac_1
CMS2_k127_2817469_32	755178.Cyan10605_3048	1.058e-12	79.0	COG2227@1|root,COG2227@2|Bacteria,1G0TK@1117|Cyanobacteria	1117|Cyanobacteria	H	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_31
CMS2_k127_2817469_34	1169161.KB897735_gene5107	5.452e-11	72.0	29CQV@1|root,2ZZP2@2|Bacteria,2HCB6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2817469_12	161156.JQKW01000006_gene1070	6.201e-74	260.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,2GH0E@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
CMS2_k127_2817469_37	1121007.AUML01000002_gene1585	7.311e-07	57.0	2A9XH@1|root,30Z5P@2|Bacteria,4PD9F@976|Bacteroidetes,1IHWY@117743|Flavobacteriia,2YK3A@290174|Aquimarina	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2823064_1	1392490.JHZX01000001_gene209	2.016e-23	117.0	COG2207@1|root,COG2207@2|Bacteria,4NIJV@976|Bacteroidetes,1HZ3N@117743|Flavobacteriia	976|Bacteroidetes	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Reg_prop,Y_Y_Y
CMS2_k127_2823064_0	1121904.ARBP01000003_gene6399	1.366e-123	430.0	COG2203@1|root,COG2208@1|root,COG3292@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3292@2|Bacteria,4NKGA@976|Bacteroidetes,47TQU@768503|Cytophagia	976|Bacteroidetes	T	Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,Reg_prop,SpoIIE,Y_Y_Y
CMS2_k127_2827954_4	933262.AXAM01000008_gene1924	6.658e-06	50.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14
CMS2_k127_2827954_3	289376.THEYE_A0575	1.26e-06	54.0	2DG5Z@1|root,2ZUNJ@2|Bacteria	2|Bacteria	S	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
CMS2_k127_2827954_0	1380391.JIAS01000013_gene3782	8.335e-145	507.0	COG3755@1|root,COG3755@2|Bacteria,1R2G9@1224|Proteobacteria,2TZJP@28211|Alphaproteobacteria,2JZ28@204441|Rhodospirillales	204441|Rhodospirillales	S	Lysozyme inhibitor LprI	-	-	-	-	-	-	-	-	-	-	-	-	LprI
CMS2_k127_2827954_2	1411123.JQNH01000001_gene1855	2.276e-13	82.0	COG4461@1|root,COG4461@2|Bacteria,1R0Z2@1224|Proteobacteria,2TYV9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Lysozyme inhibitor LprI	-	-	-	-	-	-	-	-	-	-	-	-	LprI
CMS2_k127_2827954_1	1380391.JIAS01000013_gene3781	2.233e-138	460.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,2JUYT@204441|Rhodospirillales	204441|Rhodospirillales	S	Alpha-2-Macroglobulin	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2
CMS2_k127_2833110_15	1232449.BAHV02000016_gene1829	3.457e-14	78.0	2DZY9@1|root,32VN1@2|Bacteria,1VE0V@1239|Firmicutes,24P7G@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2833110_14	1226325.HMPREF1548_00167	2.066e-19	94.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia	186801|Clostridia	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
CMS2_k127_2833110_13	1415779.JOMH01000001_gene1681	7.705e-20	98.0	COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,1RP3P@1236|Gammaproteobacteria,1X7RI@135614|Xanthomonadales	135614|Xanthomonadales	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
CMS2_k127_2833110_6	509635.N824_25910	4.442e-67	235.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,SH3_3
CMS2_k127_2833110_8	1123376.AUIU01000018_gene50	6.124e-52	205.0	COG0668@1|root,COG0668@2|Bacteria,3J0YK@40117|Nitrospirae	40117|Nitrospirae	M	Mechanosensitive ion channel	-	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
CMS2_k127_2833110_0	660470.Theba_2661	2.473e-210	666.0	COG1297@1|root,COG1297@2|Bacteria	2|Bacteria	S	iron-nicotianamine transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OPT
CMS2_k127_2833110_17	1519464.HY22_12195	5.476e-06	57.0	2BQJ0@1|root,33YRV@2|Bacteria,1FFCB@1090|Chlorobi	1090|Chlorobi	S	Domain of unknown function (DUF4412)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4412
CMS2_k127_2833110_3	1144275.COCOR_02241	8.132e-156	496.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,42KZY@68525|delta/epsilon subdivisions,2WJ4B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
CMS2_k127_2833110_5	323848.Nmul_A2092	1.125e-68	244.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,2VU4X@28216|Betaproteobacteria,372W6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Prolyl oligopeptidase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
CMS2_k127_2833110_1	864702.OsccyDRAFT_1804	6.025e-170	549.0	COG0793@1|root,COG0793@2|Bacteria,1G3PU@1117|Cyanobacteria,1HE19@1150|Oscillatoriales	1117|Cyanobacteria	E	Periplasmic protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
CMS2_k127_2833110_4	237368.SCABRO_00858	2.354e-119	393.0	COG2204@1|root,COG2204@2|Bacteria,2J2AC@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat
CMS2_k127_2833110_2	1499967.BAYZ01000167_gene6714	2.998e-159	515.0	COG2195@1|root,COG2195@2|Bacteria,2NP2Y@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M20/M25/M40	pepD	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
CMS2_k127_2833110_9	304371.MCP_0732	7.484e-49	177.0	COG0432@1|root,arCOG04214@2157|Archaea,2XYW0@28890|Euryarchaeota,2N9WB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CMS2_k127_2833110_7	880072.Desac_1962	5.039e-55	218.0	COG1629@1|root,COG4771@2|Bacteria,1RA71@1224|Proteobacteria,43CF9@68525|delta/epsilon subdivisions,2X7QB@28221|Deltaproteobacteria,2MS55@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Outer membrane protein beta-barrel family	-	-	-	ko:K16087,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.2,1.B.14.3	-	-	Plug,TonB_dep_Rec
CMS2_k127_2833110_11	398767.Glov_3569	6.585e-46	177.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,43CXZ@68525|delta/epsilon subdivisions,2X623@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_2833110_12	485913.Krac_11950	1.783e-20	104.0	COG0642@1|root,COG2205@2|Bacteria,2G8UJ@200795|Chloroflexi	200795|Chloroflexi	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA
CMS2_k127_2833110_10	1123073.KB899245_gene183	1.155e-46	187.0	COG0515@1|root,COG0515@2|Bacteria,1QVRP@1224|Proteobacteria,1T2I6@1236|Gammaproteobacteria,1XCVF@135614|Xanthomonadales	135614|Xanthomonadales	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS2_k127_2833263_2	306281.AJLK01000065_gene5426	4.716e-20	104.0	COG4249@1|root,COG4249@2|Bacteria,1GQ28@1117|Cyanobacteria,1JKBN@1189|Stigonemataceae	1117|Cyanobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	GUN4,Peptidase_C14
CMS2_k127_2833263_1	593750.Metfor_0341	6.146e-25	115.0	arCOG03732@1|root,arCOG07676@1|root,arCOG09612@1|root,arCOG03732@2157|Archaea,arCOG07676@2157|Archaea,arCOG09612@2157|Archaea,2Y4EU@28890|Euryarchaeota	28890|Euryarchaeota	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
CMS2_k127_2833263_0	1121904.ARBP01000001_gene5914	1.877e-102	362.0	COG4249@1|root,COG4249@2|Bacteria,4NH9I@976|Bacteroidetes,47XC3@768503|Cytophagia	976|Bacteroidetes	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
CMS2_k127_2833263_3	443143.GM18_3960	2.067e-05	56.0	COG2963@1|root,COG2963@2|Bacteria,1N8W3@1224|Proteobacteria,42VAX@68525|delta/epsilon subdivisions,2WRTQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
CMS2_k127_2922327_2	1123274.KB899416_gene2669	3.578e-06	49.0	COG0454@1|root,COG0456@2|Bacteria,2JB1N@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_2922327_0	531844.FIC_02536	7.481e-43	170.0	COG2850@1|root,COG2850@2|Bacteria,4NEJI@976|Bacteroidetes,1HWP6@117743|Flavobacteriia,4069A@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	S	A domain family that is part of the cupin metalloenzyme superfamily.	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_8
CMS2_k127_2936411_2	945713.IALB_0147	2.351e-34	154.0	COG2234@1|root,COG4412@1|root,COG2234@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	3.4.11.10,3.4.21.50	ko:K01337,ko:K05994,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF4968,DUF5110,F5_F8_type_C,Glyco_hydro_31,PA,Peptidase_M28,Peptidase_M6,Peptidase_S8,W_rich_C
CMS2_k127_2936411_5	215803.DB30_3970	2.569e-17	98.0	COG3266@1|root,COG3568@1|root,COG3266@2|Bacteria,COG3568@2|Bacteria,1N2ZJ@1224|Proteobacteria,42WUR@68525|delta/epsilon subdivisions,2WSUA@28221|Deltaproteobacteria,2YUA6@29|Myxococcales	28221|Deltaproteobacteria	PQ	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,LTD
CMS2_k127_2936411_0	439235.Dalk_0237	8.821e-94	344.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_2936411_1	105559.Nwat_0065	5.8e-38	145.0	2DNRM@1|root,32YT2@2|Bacteria,1N8BS@1224|Proteobacteria,1T0VB@1236|Gammaproteobacteria,1WZ7K@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
CMS2_k127_2936411_4	555779.Dthio_PD0657	2.788e-19	90.0	2DNRM@1|root,32YT2@2|Bacteria,1N8BS@1224|Proteobacteria,42XIM@68525|delta/epsilon subdivisions,2WTAT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
CMS2_k127_2936411_6	163908.KB235896_gene4873	1.521e-12	71.0	COG1669@1|root,COG1669@2|Bacteria,1G7T8@1117|Cyanobacteria	1117|Cyanobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CMS2_k127_2936411_7	1047013.AQSP01000142_gene124	1.623e-12	79.0	COG3391@1|root,COG3391@2|Bacteria,2NQ4G@2323|unclassified Bacteria	2|Bacteria	O	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,NHL,TolB_like
CMS2_k127_2936411_3	1125863.JAFN01000001_gene1554	7.944e-21	102.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,42UJ1@68525|delta/epsilon subdivisions,2WR2I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,Pentapeptide
CMS2_k127_2944766_0	1047013.AQSP01000095_gene2314	1.025e-209	660.0	COG0001@1|root,COG0001@2|Bacteria,2NNV5@2323|unclassified Bacteria	2|Bacteria	H	PFAM aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,NMO
CMS2_k127_2944766_1	945713.IALB_2675	7.465e-125	427.0	COG3104@1|root,COG3104@2|Bacteria	2|Bacteria	E	oligopeptide transport	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	MFS_1
CMS2_k127_2944766_2	1033810.HLPCO_002269	4.238e-07	58.0	COG1226@1|root,COG1226@2|Bacteria	2|Bacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	nhaP	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Ion_trans_2,Na_H_Exchanger,RyR,TrkA_N
CMS2_k127_2950680_0	1196323.ALKF01000205_gene4116	1.159e-272	857.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_2950680_1	211165.AJLN01000149_gene6649	1.492e-60	219.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1JK4D@1189|Stigonemataceae	1117|Cyanobacteria	Q	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_2964042_0	177437.HRM2_25090	8.036e-106	355.0	COG2204@1|root,COG2204@2|Bacteria,1QWNE@1224|Proteobacteria,43BTE@68525|delta/epsilon subdivisions,2X746@28221|Deltaproteobacteria,2MPJR@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
CMS2_k127_2964042_4	1341679.P253_01293	8.172e-05	47.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RYTK@1236|Gammaproteobacteria,3NT0S@468|Moraxellaceae	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,MASE5
CMS2_k127_2964042_1	1167006.UWK_00098	1.263e-77	278.0	COG1639@1|root,COG2199@1|root,COG1639@2|Bacteria,COG3706@2|Bacteria,1MVRF@1224|Proteobacteria,42USR@68525|delta/epsilon subdivisions,2WR2D@28221|Deltaproteobacteria,2MK3C@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HDOD
CMS2_k127_2964042_3	96561.Dole_2370	4.435e-09	63.0	2EC3H@1|root,3362D@2|Bacteria,1NDXP@1224|Proteobacteria,42WQJ@68525|delta/epsilon subdivisions,2WRNF@28221|Deltaproteobacteria,2MKWZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
CMS2_k127_2964042_2	1232437.KL662011_gene1449	1.685e-60	213.0	COG0484@1|root,COG0484@2|Bacteria,1RHHJ@1224|Proteobacteria,42SMN@68525|delta/epsilon subdivisions,2WPJN@28221|Deltaproteobacteria,2MNCE@213118|Desulfobacterales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
CMS2_k127_3062633_3	56107.Cylst_1820	3.021e-163	523.0	COG0520@1|root,COG0520@2|Bacteria,1G30B@1117|Cyanobacteria,1HTZW@1161|Nostocales	1117|Cyanobacteria	E	Cysteine desulfurase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS2_k127_3062633_2	880073.Calab_3685	1.351e-223	697.0	COG0473@1|root,COG0473@2|Bacteria,2NNUM@2323|unclassified Bacteria	2|Bacteria	CE	Isocitrate/isopropylmalate dehydrogenase	dlpA	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh,MoCF_biosynth,RraA-like
CMS2_k127_3062633_14	580340.Tlie_1565	2.163e-59	211.0	COG0066@1|root,COG0066@2|Bacteria,3TAFC@508458|Synergistetes	508458|Synergistetes	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
CMS2_k127_3062633_4	1047013.AQSP01000140_gene2450	1.5e-162	521.0	COG0065@1|root,COG0065@2|Bacteria,2NNYT@2323|unclassified Bacteria	2|Bacteria	E	Aconitase family (aconitate hydratase)	hacA	-	4.2.1.114,4.2.1.33,4.2.1.35,4.2.1.36	ko:K01703,ko:K01705,ko:K16792	ko00290,ko00300,ko00660,ko00680,ko00966,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00680,map00966,map01100,map01110,map01120,map01130,map01210,map01230	M00030,M00432,M00433,M00535,M00608	R03444,R03896,R03898,R03968,R04001,R04371,R08620,R08624,R08628,R08634,R08641,R08645,R09720,R10170,R10391,R10392,R10393,R10394,R10395,R10396	RC00497,RC00498,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
CMS2_k127_3062633_12	234267.Acid_6315	6.374e-78	281.0	COG2234@1|root,COG2234@2|Bacteria,3Y341@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
CMS2_k127_3062633_22	865938.Weevi_0772	1.818e-07	61.0	COG2834@1|root,COG2834@2|Bacteria,4NGK5@976|Bacteroidetes,1I0G7@117743|Flavobacteriia	976|Bacteroidetes	M	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3062633_11	1219084.AP014508_gene745	5.573e-84	289.0	COG0809@1|root,COG0809@2|Bacteria,2GBXV@200918|Thermotogae	200918|Thermotogae	F	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
CMS2_k127_3062633_8	880073.Calab_0506	6.079e-114	377.0	COG0845@1|root,COG0845@2|Bacteria,2NQN5@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
CMS2_k127_3062633_0	880073.Calab_0505	0.0	1262.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS2_k127_3062633_5	880073.Calab_0504	8.995e-134	440.0	COG1538@1|root,COG1538@2|Bacteria,2NPKK@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_3062633_18	1254432.SCE1572_27630	1.326e-28	123.0	COG1309@1|root,COG1309@2|Bacteria,1N659@1224|Proteobacteria,42W0S@68525|delta/epsilon subdivisions,2WRFW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K03577	-	M00647	-	-	ko00000,ko00002,ko03000	-	-	-	TetR_N
CMS2_k127_3062633_9	1047013.AQSP01000142_gene140	2.152e-86	292.0	COG3279@1|root,COG3279@2|Bacteria,2NRAD@2323|unclassified Bacteria	2|Bacteria	KT	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
CMS2_k127_3062633_10	1047013.AQSP01000142_gene141	1.079e-84	294.0	COG2972@1|root,COG2972@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
CMS2_k127_3062633_16	1047013.AQSP01000142_gene142	3.492e-49	184.0	COG4758@1|root,COG4758@2|Bacteria	2|Bacteria	KT	membrane	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF1707,DUF2154
CMS2_k127_3062633_1	313606.M23134_02095	1.351e-283	907.0	COG1649@1|root,COG3291@1|root,COG1649@2|Bacteria,COG3291@2|Bacteria,4PMDA@976|Bacteroidetes,47Y1M@768503|Cytophagia	976|Bacteroidetes	O	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	MAM,PKD,Sortilin-Vps10
CMS2_k127_3062633_13	1121930.AQXG01000003_gene2626	1.367e-60	226.0	COG1228@1|root,COG1228@2|Bacteria,4NE5U@976|Bacteroidetes	976|Bacteroidetes	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS2_k127_3062633_7	1123508.JH636441_gene3225	1.613e-122	426.0	COG1228@1|root,COG1228@2|Bacteria,2IYFS@203682|Planctomycetes	203682|Planctomycetes	Q	COG1228 Imidazolonepropionase and related	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
CMS2_k127_3062633_15	649747.HMPREF0083_02827	9.237e-55	200.0	COG2230@1|root,COG2230@2|Bacteria,1UMJ8@1239|Firmicutes,4HW8V@91061|Bacilli	91061|Bacilli	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
CMS2_k127_3062633_20	521045.Kole_0154	5.034e-22	102.0	COG1725@1|root,COG1725@2|Bacteria,2GDGX@200918|Thermotogae	200918|Thermotogae	K	PFAM regulatory protein GntR HTH	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS2_k127_3062633_19	1033733.CAEK01000017_gene730	2.553e-24	113.0	COG1131@1|root,COG1131@2|Bacteria,1TPUP@1239|Firmicutes,249FR@186801|Clostridia,22G5E@1570339|Peptoniphilaceae	186801|Clostridia	V	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_3062633_6	338966.Ppro_2089	8.229e-132	443.0	COG0784@1|root,COG2202@1|root,COG4936@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4936@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
CMS2_k127_3062633_17	1304284.L21TH_2627	2.77e-32	138.0	COG5464@1|root,COG5464@2|Bacteria,1UGME@1239|Firmicutes,248B2@186801|Clostridia,36HRR@31979|Clostridiaceae	186801|Clostridia	S	PFAM transposase YhgA family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
CMS2_k127_3062633_21	1089548.KI783301_gene1955	1.073e-18	91.0	COG5464@1|root,COG5464@2|Bacteria,1UGME@1239|Firmicutes,4HEK5@91061|Bacilli	91061|Bacilli	S	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
CMS2_k127_3073900_0	118005.AWNK01000004_gene1064	4.59e-279	905.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3073900_1	211114.JOEF01000042_gene6071	5.239e-52	213.0	COG4122@1|root,COG4122@2|Bacteria,2I410@201174|Actinobacteria,4E3J7@85010|Pseudonocardiales	201174|Actinobacteria	S	O-methyltransferase activity	-	-	2.1.1.2	ko:K00542	ko00260,ko00330,ko01100,map00260,map00330,map01100	M00047	R01883	RC00003,RC00614	ko00000,ko00001,ko00002,ko01000	-	-	-	-
CMS2_k127_3096286_8	1232437.KL661958_gene2890	5.706e-17	81.0	COG1034@1|root,COG1034@2|Bacteria,1RK80@1224|Proteobacteria,43CTD@68525|delta/epsilon subdivisions,2X80Y@28221|Deltaproteobacteria,2MPQ2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4_7
CMS2_k127_3096286_4	1232437.KL661958_gene2891	7.142e-112	366.0	COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,42PRH@68525|delta/epsilon subdivisions,2WPXH@28221|Deltaproteobacteria,2MJR0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ,MobB
CMS2_k127_3096286_1	880073.Calab_0508	1.807e-161	556.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_9,Response_reg
CMS2_k127_3096286_3	880526.KE386488_gene1106	7.551e-125	410.0	COG0436@1|root,COG0436@2|Bacteria,4P02V@976|Bacteroidetes,2FWTB@200643|Bacteroidia	976|Bacteroidetes	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS2_k127_3096286_9	406327.Mevan_1313	1.666e-13	79.0	COG1773@1|root,arCOG04391@2157|Archaea,2Y080@28890|Euryarchaeota,23RCD@183939|Methanococci	183939|Methanococci	C	PFAM Rubredoxin-type Fe(Cys)4 protein	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
CMS2_k127_3096286_7	1122947.FR7_0022	7.867e-34	139.0	COG1592@1|root,COG1592@2|Bacteria,1VCQR@1239|Firmicutes,4H5RG@909932|Negativicutes	909932|Negativicutes	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3096286_6	1047013.AQSP01000106_gene1773	8.729e-42	171.0	COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4976,Sulfatase
CMS2_k127_3096286_5	547559.Nmag_3999	3.389e-62	231.0	COG2843@1|root,arCOG07503@2157|Archaea	2157|Archaea	M	enzyme of poly-gamma-glutamate biosynthesis (Capsule formation)	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
CMS2_k127_3096286_2	1265503.KB905162_gene3593	2.383e-145	487.0	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria,2Q7GY@267889|Colwelliaceae	1236|Gammaproteobacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_3096286_0	1121121.KB894288_gene2764	3.549e-216	700.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3100043_13	59374.Fisuc_2472	2.644e-14	76.0	COG4704@1|root,COG4704@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Fib_succ_major
CMS2_k127_3100043_12	420247.Msm_1484	1.896e-21	107.0	COG0842@1|root,arCOG01463@2157|Archaea,2Y34U@28890|Euryarchaeota,23PDD@183925|Methanobacteria	183925|Methanobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
CMS2_k127_3100043_9	1536772.R70723_06045	1.568e-91	310.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,4HA8K@91061|Bacilli,26TFZ@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_3100043_1	502025.Hoch_6312	1.359e-140	467.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_3100043_0	502025.Hoch_1667	7.745e-144	477.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_3100043_2	502025.Hoch_1667	3.788e-140	466.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_3100043_3	84531.JMTZ01000011_gene3120	1.681e-132	445.0	COG3227@1|root,COG4935@1|root,COG3227@2|Bacteria,COG4935@2|Bacteria,1P416@1224|Proteobacteria,1RR7I@1236|Gammaproteobacteria,1X4PD@135614|Xanthomonadales	135614|Xanthomonadales	E	Zinc metalloprotease (Elastase)	-	-	3.4.24.25,3.4.24.26	ko:K01399,ko:K08604	ko01503,ko02024,ko05110,ko05111,map01503,map02024,map05110,map05111	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PPC,P_proprotein,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_3100043_5	502025.Hoch_1667	1.425e-125	425.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_3100043_7	502025.Hoch_1667	5.712e-125	423.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_3100043_6	502025.Hoch_1667	2.38e-125	425.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_3100043_4	84531.JMTZ01000011_gene3120	3.64e-128	433.0	COG3227@1|root,COG4935@1|root,COG3227@2|Bacteria,COG4935@2|Bacteria,1P416@1224|Proteobacteria,1RR7I@1236|Gammaproteobacteria,1X4PD@135614|Xanthomonadales	135614|Xanthomonadales	E	Zinc metalloprotease (Elastase)	-	-	3.4.24.25,3.4.24.26	ko:K01399,ko:K08604	ko01503,ko02024,ko05110,ko05111,map01503,map02024,map05110,map05111	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PPC,P_proprotein,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_3100043_11	1237149.C900_00689	4.047e-41	158.0	COG0727@1|root,COG0727@2|Bacteria,4P5VP@976|Bacteroidetes	976|Bacteroidetes	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
CMS2_k127_3100043_10	428126.CLOSPI_01409	4.122e-44	166.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,3VQJ0@526524|Erysipelotrichia	526524|Erysipelotrichia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
CMS2_k127_3100043_8	459349.CLOAM0299	2.726e-105	355.0	COG1167@1|root,COG1167@2|Bacteria,2NQG7@2323|unclassified Bacteria	2|Bacteria	EK	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
CMS2_k127_310263_0	933262.AXAM01000025_gene3423	1.517e-151	495.0	COG3172@1|root,COG3172@2|Bacteria,1MXEI@1224|Proteobacteria,42N4F@68525|delta/epsilon subdivisions,2WKWK@28221|Deltaproteobacteria,2MI5H@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Domain of unknown function (DUF4301)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4301
CMS2_k127_310263_3	1189612.A33Q_1366	3.712e-127	423.0	COG2939@1|root,COG2939@2|Bacteria,4NF48@976|Bacteroidetes,47KU0@768503|Cytophagia	976|Bacteroidetes	E	Serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
CMS2_k127_310263_1	1227739.Hsw_3687	9.814e-151	507.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NF70@976|Bacteroidetes,47JEZ@768503|Cytophagia	976|Bacteroidetes	EU	Peptidase S9, prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
CMS2_k127_310263_4	1117314.PCIT_15805	4.897e-115	392.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,2Q2WU@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	cocE	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS2_k127_310263_2	1358423.N180_04995	4.236e-138	456.0	COG2939@1|root,COG2939@2|Bacteria,4NF48@976|Bacteroidetes,1ISNT@117747|Sphingobacteriia	976|Bacteroidetes	E	Peptidase S10	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
CMS2_k127_310263_5	1487953.JMKF01000085_gene4347	2.849e-68	245.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,CHU_C,Calx-beta,NHL,PA14,VCBS
CMS2_k127_310263_8	1146883.BLASA_0999	1.202e-25	124.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,PKD
CMS2_k127_310263_7	888050.HMPREF9004_0475	2.999e-26	126.0	COG2755@1|root,COG3291@1|root,COG2755@2|Bacteria,COG3291@2|Bacteria,2IEXF@201174|Actinobacteria,4D34K@85005|Actinomycetales	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL,Lipase_GDSL_2,PKD,VWA
CMS2_k127_310263_10	880073.Calab_0091	2.339e-23	117.0	COG1629@1|root,COG4771@2|Bacteria,2NRGW@2323|unclassified Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
CMS2_k127_310263_9	445335.CBN_2136	5.349e-24	116.0	29WK7@1|root,30I6P@2|Bacteria,1USAE@1239|Firmicutes,24YTF@186801|Clostridia,36QEC@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_310263_6	1535287.JP74_00480	1.254e-34	149.0	COG1715@1|root,COG1715@2|Bacteria	2|Bacteria	V	Restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_cat
CMS2_k127_310717_2	573061.Clocel_2487	1.765e-208	684.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_310717_4	573061.Clocel_3944	3.961e-163	534.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36F06@31979|Clostridiaceae	186801|Clostridia	Q	Amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
CMS2_k127_310717_1	1121121.KB894288_gene2765	0.0	1515.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_310717_5	588581.Cpap_3819	2.591e-71	257.0	COG0621@1|root,COG0621@2|Bacteria,1UY0Y@1239|Firmicutes,24EH9@186801|Clostridia	186801|Clostridia	J	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,UPF0004
CMS2_k127_310717_3	1087481.AGFX01000046_gene2041	4.948e-205	689.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_310717_0	1196323.ALKF01000205_gene4114	0.0	2175.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3113374_0	1117108.PAALTS15_22598	0.0	1493.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3115462_0	373903.Hore_00590	5.375e-188	597.0	COG0591@1|root,COG0591@2|Bacteria,1U2RC@1239|Firmicutes,25MU8@186801|Clostridia,3WBVY@53433|Halanaerobiales	186801|Clostridia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_3115462_1	1340493.JNIF01000003_gene1477	5.537e-53	205.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	ko:K20333	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	FGE-sulfatase,NACHT
CMS2_k127_3115462_2	593750.Metfor_0341	1.287e-23	115.0	arCOG03732@1|root,arCOG07676@1|root,arCOG09612@1|root,arCOG03732@2157|Archaea,arCOG07676@2157|Archaea,arCOG09612@2157|Archaea,2Y4EU@28890|Euryarchaeota	28890|Euryarchaeota	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
CMS2_k127_3115462_3	631362.Thi970DRAFT_04989	0.0001422	45.0	COG3744@1|root,COG3744@2|Bacteria	2|Bacteria	S	ribonuclease activity	-	GO:0005575,GO:0005576,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_3115720_0	1125863.JAFN01000001_gene3357	4.37e-112	366.0	COG1024@1|root,COG1024@2|Bacteria,1NDT7@1224|Proteobacteria,42PZ0@68525|delta/epsilon subdivisions,2WM9Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS2_k127_3115720_1	335543.Sfum_2600	6.924e-73	253.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,2MSJJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS2_k127_3116237_0	1499967.BAYZ01000100_gene3454	3.081e-151	490.0	2EVWS@1|root,33PAF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3130398_3	1042163.BRLA_c025650	4.061e-119	405.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15662	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3130398_0	755731.Clo1100_0890	0.0	2394.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3130398_2	1195236.CTER_0312	0.0	1427.0	COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_3130398_1	755731.Clo1100_0890	0.0	1995.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3131194_0	1501230.ET33_18925	0.0	3646.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_3131194_1	63737.Npun_R3024	0.0	1429.0	COG0300@1|root,COG3321@1|root,COG0300@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1HJVE@1161|Nostocales	1117|Cyanobacteria	Q	COGs COG3321 Polyketide synthase modules and related protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3131194_3	1042163.BRLA_c036810	1.487e-107	370.0	COG1020@1|root,COG1020@2|Bacteria,1VS0X@1239|Firmicutes,4HURN@91061|Bacilli,26VZQ@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3131194_2	1007103.AFHW01000091_gene3328	0.0	1351.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	pmxE	-	-	ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3145017_22	1121403.AUCV01000013_gene3968	1.732e-21	97.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,42S1N@68525|delta/epsilon subdivisions,2WNUH@28221|Deltaproteobacteria,2MJVE@213118|Desulfobacterales	28221|Deltaproteobacteria	O	TIGRFAM thioredoxin	trx-3	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
CMS2_k127_3145017_7	289377.HL41_04930	1.66e-113	376.0	COG1180@1|root,COG1180@2|Bacteria,2GH8R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
CMS2_k127_3145017_1	1121405.dsmv_1623	1.124e-246	782.0	COG0306@1|root,COG0306@2|Bacteria,1QAR3@1224|Proteobacteria,42P0C@68525|delta/epsilon subdivisions,2WJWM@28221|Deltaproteobacteria,2MINM@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Phosphate transporter family	-	-	-	-	-	-	-	-	-	-	-	-	PHO4
CMS2_k127_3145017_8	1047013.AQSP01000072_gene988	3.51e-100	342.0	COG2239@1|root,COG2239@2|Bacteria,2NP6V@2323|unclassified Bacteria	2|Bacteria	P	Acts as a magnesium transporter	mgtE	GO:0000287,GO:0003674,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015693,GO:0030001,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0051179,GO:0051234,GO:0070838,GO:0072511	3.6.1.1	ko:K03281,ko:K04767,ko:K06213,ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000,ko02000	1.A.26.1,2.A.49	-	iYO844.BSU13300	CBS,MgtE,MgtE_N
CMS2_k127_3145017_20	1047013.AQSP01000072_gene989	1.992e-24	112.0	COG1381@1|root,COG1381@2|Bacteria,2NPV3@2323|unclassified Bacteria	2|Bacteria	L	Involved in DNA repair and RecF pathway recombination	recO	GO:0008150,GO:0009314,GO:0009628,GO:0050896	2.6.99.2	ko:K03474,ko:K03584	ko00750,ko01100,ko03440,map00750,map01100,map03440	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	RecO_C,RecO_N
CMS2_k127_3145017_15	1089439.KB902239_gene386	2.948e-41	157.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria,460T8@72273|Thiotrichales	72273|Thiotrichales	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
CMS2_k127_3145017_19	1121403.AUCV01000010_gene1368	4.353e-27	114.0	COG2204@1|root,COG2204@2|Bacteria,1QW8K@1224|Proteobacteria,42V8F@68525|delta/epsilon subdivisions,2WRMW@28221|Deltaproteobacteria,2MNUV@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_3145017_18	1191523.MROS_1597	9.858e-28	114.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	nrdH	-	-	ko:K03676,ko:K06191	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
CMS2_k127_3145017_6	1408473.JHXO01000006_gene1277	1.623e-127	421.0	COG1566@1|root,COG1566@2|Bacteria,4NF6F@976|Bacteroidetes,2FN2N@200643|Bacteroidia	976|Bacteroidetes	V	HlyD family secretion protein	-	-	-	ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
CMS2_k127_3145017_0	1237149.C900_05278	0.0	1058.0	COG2274@1|root,COG2274@2|Bacteria,4NE19@976|Bacteroidetes,47JYM@768503|Cytophagia	976|Bacteroidetes	V	ABC transporter transmembrane region	lktB	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran,Peptidase_C39
CMS2_k127_3145017_10	243231.GSU1654	1.09e-92	316.0	COG3437@1|root,COG3437@2|Bacteria,1RGGM@1224|Proteobacteria,42RTT@68525|delta/epsilon subdivisions,2WNA8@28221|Deltaproteobacteria,43TJF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Response receiver-modulated cyclic diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,Response_reg
CMS2_k127_3145017_3	1122917.KB899668_gene4556	1.943e-152	490.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,4HB33@91061|Bacilli,26QFD@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
CMS2_k127_3145017_5	269797.Mbar_A0176	8.104e-129	417.0	COG1830@1|root,arCOG04044@2157|Archaea,2XSY2@28890|Euryarchaeota,2N9FM@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase	-	-	2.2.1.11,4.1.2.13	ko:K16305	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R10049,R10050	RC00438,RC00439,RC02301,RC03034	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
CMS2_k127_3145017_9	880073.Calab_3182	2.621e-97	332.0	COG2067@1|root,COG2067@2|Bacteria,2NQYN@2323|unclassified Bacteria	2|Bacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
CMS2_k127_3145017_4	1047013.AQSP01000110_gene67	1.133e-130	426.0	COG0598@1|root,COG0598@2|Bacteria,2NPAW@2323|unclassified Bacteria	2|Bacteria	P	CorA-like Mg2+ transporter protein	corA	GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
CMS2_k127_3145017_21	1047013.AQSP01000139_gene2399	1.091e-21	102.0	COG5401@1|root,COG5401@2|Bacteria,2NPV5@2323|unclassified Bacteria	2|Bacteria	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
CMS2_k127_3145017_13	1047013.AQSP01000139_gene2398	1.551e-59	221.0	COG0860@1|root,COG0860@2|Bacteria,2NPCZ@2323|unclassified Bacteria	2|Bacteria	M	Ami_3	lytC_1	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3,SLH
CMS2_k127_3145017_23	913865.DOT_1535	1.567e-16	82.0	COG3118@1|root,COG3118@2|Bacteria,1VEPC@1239|Firmicutes,24UN5@186801|Clostridia	186801|Clostridia	O	TIGRFAM bacillithiol system protein YtxJ	-	-	-	-	-	-	-	-	-	-	-	-	DUF2847
CMS2_k127_3145017_16	224324.aq_185	1.224e-40	155.0	COG0615@1|root,COG0615@2|Bacteria,2G3YJ@200783|Aquificae	200783|Aquificae	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
CMS2_k127_3145017_14	1469557.JSWF01000031_gene1998	6.89e-46	179.0	2DTK1@1|root,33KQ9@2|Bacteria,4NYZ2@976|Bacteroidetes,1I7B1@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PD40
CMS2_k127_3145017_2	1047013.AQSP01000132_gene1707	4.205e-153	494.0	COG1134@1|root,COG1134@2|Bacteria,2NP4S@2323|unclassified Bacteria	2|Bacteria	GM	ATPases associated with a variety of cellular activities	rfbB	-	3.6.3.38,3.6.3.40	ko:K01990,ko:K09689,ko:K09691,ko:K09693	ko02010,map02010	M00249,M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.101,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
CMS2_k127_3145017_11	1047013.AQSP01000132_gene1706	1.109e-92	312.0	COG1682@1|root,COG1682@2|Bacteria,2NQ2H@2323|unclassified Bacteria	2|Bacteria	U	ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
CMS2_k127_3145017_17	1047013.AQSP01000132_gene1705	1.736e-37	150.0	COG4123@1|root,COG4123@2|Bacteria,2NPPP@2323|unclassified Bacteria	2|Bacteria	S	Putative RNA methylase family UPF0020	-	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS
CMS2_k127_3145017_12	1047013.AQSP01000094_gene29	2.14e-90	312.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2NP0G@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the CinA family	cinA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
CMS2_k127_3162992_2	1121405.dsmv_3524	1.46e-07	55.0	COG0582@1|root,COG0582@2|Bacteria,1RFW7@1224|Proteobacteria,42RZ5@68525|delta/epsilon subdivisions,2WNSK@28221|Deltaproteobacteria,2MJSN@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
CMS2_k127_3162992_3	391587.KAOT1_01544	0.0002915	49.0	COG4704@1|root,COG4704@2|Bacteria,4NUS8@976|Bacteroidetes,1I3YT@117743|Flavobacteriia	976|Bacteroidetes	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2141
CMS2_k127_3162992_1	580332.Slit_1114	1.564e-38	146.0	COG4551@1|root,COG4551@2|Bacteria,1N05F@1224|Proteobacteria,2VT1K@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Low molecular weight phosphotyrosine protein phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3162992_0	1121468.AUBR01000026_gene2916	5.879e-43	164.0	COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,24I2P@186801|Clostridia,42GMX@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain in cystathionine beta-synthase and other proteins.	acuB	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
CMS2_k127_3166357_1	1174528.JH992893_gene6031	4.437e-156	515.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_3166357_0	697284.ERIC2_c18050	0.0	2192.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3168083_2	755731.Clo1100_2633	6.787e-157	512.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3168083_1	118005.AWNK01000004_gene1064	2.257e-299	986.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3168083_3	1007103.AFHW01000010_gene6122	2.778e-50	208.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_3168083_0	1291050.JAGE01000001_gene2515	0.0	1039.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WNP0@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_3169686_6	930169.B5T_02090	9.659e-12	77.0	COG1305@1|root,COG3209@1|root,COG1305@2|Bacteria,COG3209@2|Bacteria,1QW4H@1224|Proteobacteria,1T42N@1236|Gammaproteobacteria,1XMP6@135619|Oceanospirillales	135619|Oceanospirillales	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
CMS2_k127_3169686_2	1121378.KB899700_gene1985	1.104e-21	109.0	COG3210@1|root,32SME@2|Bacteria	2|Bacteria	U	Bacterial EndoU nuclease	-	-	-	-	-	-	-	-	-	-	-	-	EndoU_bacteria
CMS2_k127_3169686_0	660470.Theba_0138	4.492e-35	138.0	COG0286@1|root,COG0286@2|Bacteria	2|Bacteria	V	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
CMS2_k127_3169686_4	660470.Theba_0138	3.471e-18	87.0	COG0286@1|root,COG0286@2|Bacteria	2|Bacteria	V	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
CMS2_k127_3169686_5	891968.Anamo_1874	1.503e-15	83.0	2CFPC@1|root,31SN4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3169686_1	891968.Anamo_1874	2.49e-24	104.0	2CFPC@1|root,31SN4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3169686_7	90675.XP_010448079.1	1.037e-11	68.0	COG4281@1|root,KOG0817@2759|Eukaryota,37HHD@33090|Viridiplantae,3G7IU@35493|Streptophyta,3HTJQ@3699|Brassicales	35493|Streptophyta	I	acyl-CoA-binding domain-containing protein	-	GO:0000062,GO:0000166,GO:0001666,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005778,GO:0005783,GO:0005789,GO:0005886,GO:0006810,GO:0006869,GO:0006950,GO:0008150,GO:0009514,GO:0009628,GO:0010035,GO:0010038,GO:0010288,GO:0010876,GO:0012505,GO:0016020,GO:0017076,GO:0030554,GO:0031090,GO:0031903,GO:0031984,GO:0032553,GO:0032555,GO:0032559,GO:0032791,GO:0033036,GO:0033218,GO:0036094,GO:0036293,GO:0042175,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0050896,GO:0051179,GO:0051234,GO:0070482,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:0098588,GO:0098805,GO:0098827,GO:1901265,GO:1901363,GO:1901567,GO:1901681	-	-	-	-	-	-	-	-	-	-	ACBP,Ank_2,Ank_4,Ank_5
CMS2_k127_3169686_3	671065.MetMK1DRAFT_00016260	1.663e-20	98.0	COG0666@1|root,arCOG04004@2157|Archaea,2XS0N@28889|Crenarchaeota	28889|Crenarchaeota	S	ankyrin repeats	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_4
CMS2_k127_3171088_1	768706.Desor_3736	6.393e-130	437.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,260Y0@186807|Peptococcaceae	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	ko:K15664	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3171088_0	755731.Clo1100_1305	6.899e-302	966.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36QT1@31979|Clostridiaceae	186801|Clostridia	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_31,NAD_binding_4,PP-binding,ketoacyl-synt
CMS2_k127_3191189_1	933262.AXAM01000019_gene1132	1.493e-12	70.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_3191189_0	933262.AXAM01000019_gene1132	1.318e-13	72.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_3191189_2	1408422.JHYF01000020_gene1798	9.696e-07	54.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,36DSW@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
CMS2_k127_3194713_0	317619.ANKN01000230_gene224	1.018e-43	184.0	COG1511@1|root,COG1511@2|Bacteria,1G29D@1117|Cyanobacteria	1117|Cyanobacteria	L	Tubulin like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,Tubulin_2,zinc_ribbon_2
CMS2_k127_3194713_1	1499967.BAYZ01000026_gene1569	1.205e-27	131.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
CMS2_k127_3218322_13	1237149.C900_05552	2.385e-64	251.0	COG3227@1|root,COG3291@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,4NJK3@976|Bacteroidetes,47TYM@768503|Cytophagia	976|Bacteroidetes	E	Pregnancy-associated plasma protein-A	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_M43,fn3
CMS2_k127_3218322_1	502025.Hoch_1667	6.149e-143	492.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_3218322_10	1454010.JEOE01000015_gene1130	6.74e-82	309.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
CMS2_k127_3218322_15	313606.M23134_02095	3.569e-50	206.0	COG1649@1|root,COG3291@1|root,COG1649@2|Bacteria,COG3291@2|Bacteria,4PMDA@976|Bacteroidetes,47Y1M@768503|Cytophagia	976|Bacteroidetes	O	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	MAM,PKD,Sortilin-Vps10
CMS2_k127_3218322_2	502025.Hoch_1667	1.179e-140	491.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_3218322_21	1121904.ARBP01000002_gene6780	6.273e-15	89.0	COG3291@1|root,COG4733@1|root,COG3291@2|Bacteria,COG4733@2|Bacteria,4NGV7@976|Bacteroidetes	976|Bacteroidetes	L	PKD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Laminin_G_3,PKD,Peptidase_M14
CMS2_k127_3218322_3	28229.ND2E_0431	3.367e-136	460.0	COG2340@1|root,COG2931@1|root,COG3227@1|root,COG4932@1|root,COG5644@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria,COG3227@2|Bacteria,COG4932@2|Bacteria,COG5644@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,2Q7GE@267889|Colwelliaceae	1236|Gammaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	ko:K11005	-	-	-	-	ko00000,ko02000,ko02042	1.C.11	-	-	Big_3_2,Cadherin_3,Calx-beta,He_PIG,HemolysinCabind,OmpA_membrane,RTX,RTX_C,VWA_2,fn3
CMS2_k127_3218322_20	84531.JMTZ01000001_gene2271	3.18e-16	94.0	COG3291@1|root,COG3420@1|root,COG4935@1|root,COG3291@2|Bacteria,COG3420@2|Bacteria,COG4935@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	3.4.11.10,3.4.21.50,3.4.24.25,3.4.24.3	ko:K01337,ko:K01387,ko:K05994,ko:K08604,ko:K14645,ko:K20276	ko02024,ko05110,ko05111,map02024,map05110,map05111	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02042,ko03110	-	-	-	Inhibitor_I9,LVIVD,PKD,P_proprotein,Peptidase_M14,Peptidase_S8
CMS2_k127_3218322_11	313606.M23134_00105	1.999e-79	299.0	COG1649@1|root,COG3291@1|root,COG4733@1|root,COG1649@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,4NJK3@976|Bacteroidetes,47TYM@768503|Cytophagia	976|Bacteroidetes	E	Pregnancy-associated plasma protein-A	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_M43
CMS2_k127_3218322_4	459349.CLOAM1219	2.046e-126	443.0	COG2957@1|root,COG2957@2|Bacteria	2|Bacteria	E	agmatine deiminase activity	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph,Peptidase_C25,Peptidase_C25_C,Propeptide_C25
CMS2_k127_3218322_6	1237149.C900_05552	4.422e-92	338.0	COG3227@1|root,COG3291@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,4NJK3@976|Bacteroidetes,47TYM@768503|Cytophagia	976|Bacteroidetes	E	Pregnancy-associated plasma protein-A	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_M43,fn3
CMS2_k127_3218322_5	459349.CLOAM1219	2.465e-122	430.0	COG2957@1|root,COG2957@2|Bacteria	2|Bacteria	E	agmatine deiminase activity	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph,Peptidase_C25,Peptidase_C25_C,Propeptide_C25
CMS2_k127_3218322_23	873533.HMPREF0663_10287	4.511e-11	70.0	2FJRB@1|root,34BE7@2|Bacteria,4P5QR@976|Bacteroidetes,2FYTE@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3218322_7	386456.JQKN01000008_gene1609	1.731e-89	303.0	COG2816@1|root,arCOG01076@2157|Archaea,2XWVX@28890|Euryarchaeota,23PDI@183925|Methanobacteria	183925|Methanobacteria	L	NADH pyrophosphatase-like rudimentary NUDIX domain	-	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
CMS2_k127_3218322_8	717606.PaecuDRAFT_2821	1.08e-88	310.0	2E1DH@1|root,32WST@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3218322_22	1317122.ATO12_17180	2.046e-11	76.0	297BT@1|root,2ZUJD@2|Bacteria,4P87V@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3218322_0	502025.Hoch_6312	3.38e-143	481.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_3218322_17	1123228.AUIH01000094_gene1674	2.728e-34	152.0	COG4935@1|root,COG5276@1|root,COG4935@2|Bacteria,COG5276@2|Bacteria,1R5D5@1224|Proteobacteria,1RMBK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,LVIVD,P_proprotein
CMS2_k127_3218322_18	319225.Plut_1741	3.351e-28	118.0	COG1595@1|root,COG1595@2|Bacteria,1FE7H@1090|Chlorobi	1090|Chlorobi	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_3218322_24	1484460.JSWG01000015_gene957	2.546e-06	58.0	2B7QT@1|root,320WW@2|Bacteria,4NQFJ@976|Bacteroidetes,1I39X@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LTXXQ
CMS2_k127_3218322_14	3880.AES59975	8.346e-57	204.0	COG1535@1|root,2QQB1@2759|Eukaryota,37IJ0@33090|Viridiplantae,3GBAF@35493|Streptophyta,4JHQ9@91835|fabids	35493|Streptophyta	Q	Isochorismatase family	-	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008936,GO:0009117,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019362,GO:0019637,GO:0019674,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS2_k127_3218322_16	331678.Cphamn1_2133	1.13e-42	161.0	COG3206@1|root,COG3206@2|Bacteria,1FEGE@1090|Chlorobi	1090|Chlorobi	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
CMS2_k127_322763_40	402777.KB235903_gene1775	6.597e-32	136.0	COG4886@1|root,COG4886@2|Bacteria,1G4SR@1117|Cyanobacteria,1HAQW@1150|Oscillatoriales	1117|Cyanobacteria	G	Leucine-rich repeat	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	LRR_4,LRR_6,LRR_8
CMS2_k127_322763_3	717231.Flexsi_2305	2.43e-228	735.0	COG0178@1|root,COG0178@2|Bacteria,2GEPB@200930|Deferribacteres	200930|Deferribacteres	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS2_k127_322763_28	1047013.AQSP01000079_gene2044	9.328e-63	231.0	COG0845@1|root,COG0845@2|Bacteria,2NR3D@2323|unclassified Bacteria	2|Bacteria	M	Biotin-lipoyl like	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS2_k127_322763_2	1047013.AQSP01000079_gene2041	1.561e-234	763.0	COG0841@1|root,COG0841@2|Bacteria,2NQI6@2323|unclassified Bacteria	2|Bacteria	V	AcrB/AcrD/AcrF family	mdtC	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS2_k127_322763_8	1047013.AQSP01000102_gene979	3.083e-179	599.0	COG0841@1|root,COG0841@2|Bacteria,2NQF8@2323|unclassified Bacteria	2|Bacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS2_k127_322763_25	234267.Acid_4256	5.699e-85	288.0	COG0577@1|root,COG1131@1|root,COG0577@2|Bacteria,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	CcmA5	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_322763_18	1279009.ADICEAN_01064	2.612e-112	379.0	COG4784@1|root,COG4784@2|Bacteria,4PM59@976|Bacteroidetes,47MK2@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CMS2_k127_322763_4	1499967.BAYZ01000017_gene6263	3.914e-218	692.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	MdlB	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS2_k127_322763_6	1499967.BAYZ01000017_gene6262	2.628e-196	628.0	COG1132@1|root,COG1132@2|Bacteria,2NNN4@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter transmembrane region	yheI	-	-	ko:K06147,ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS2_k127_322763_23	471223.GWCH70_2121	4.282e-97	329.0	COG0438@1|root,COG0438@2|Bacteria,1TPS8@1239|Firmicutes,4HA43@91061|Bacilli,1WE1P@129337|Geobacillus	91061|Bacilli	M	Glycosyl transferase 4-like	bshA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_322763_24	1499967.BAYZ01000017_gene6261	1.068e-89	302.0	COG2120@1|root,COG2120@2|Bacteria,2NPAV@2323|unclassified Bacteria	2|Bacteria	S	GlcNAc-PI de-N-acetylase	bshB1	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
CMS2_k127_322763_15	1499967.BAYZ01000069_gene1887	1.185e-137	449.0	COG4365@1|root,COG4365@2|Bacteria,2NP8Q@2323|unclassified Bacteria	2|Bacteria	S	Bacillithiol biosynthesis BshC	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
CMS2_k127_322763_32	880073.Calab_3787	2.24e-52	195.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	yccK	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25,Methyltransf_31,TehB
CMS2_k127_322763_31	331678.Cphamn1_0282	7.586e-55	199.0	COG0491@1|root,COG0491@2|Bacteria,1FDV9@1090|Chlorobi	1090|Chlorobi	S	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_322763_21	1047013.AQSP01000056_gene1916	1.343e-98	326.0	COG1136@1|root,COG1136@2|Bacteria,2NP53@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_322763_10	1047013.AQSP01000056_gene1917	3.7e-152	491.0	COG0577@1|root,COG0577@2|Bacteria,2NP20@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	macB_3	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_322763_14	1047013.AQSP01000056_gene1918	1.686e-141	460.0	COG0577@1|root,COG0577@2|Bacteria,2NP20@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	macB_3	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_322763_16	1047013.AQSP01000056_gene1919	6.345e-134	435.0	COG0845@1|root,COG0845@2|Bacteria,2NR6A@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	VVA1500	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP
CMS2_k127_322763_37	1047013.AQSP01000106_gene1773	2.659e-42	177.0	COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4976,Sulfatase
CMS2_k127_322763_35	1047013.AQSP01000084_gene762	5.894e-47	175.0	COG1974@1|root,COG1974@2|Bacteria,2NPJG@2323|unclassified Bacteria	2|Bacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
CMS2_k127_322763_22	1047013.AQSP01000084_gene763	2.522e-98	335.0	COG0389@1|root,COG0389@2|Bacteria,2NP5S@2323|unclassified Bacteria	2|Bacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
CMS2_k127_322763_0	880073.Calab_1855	0.0	1084.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,2NNW8@2323|unclassified Bacteria	2|Bacteria	L	DNA helicase	yqxK	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4178,PHP_C,UvrD-helicase,UvrD_C
CMS2_k127_322763_12	1120985.AUMI01000014_gene1107	3.419e-145	472.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,4H2IF@909932|Negativicutes	1239|Firmicutes	E	diaminopimelate decarboxylase	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
CMS2_k127_322763_50	1307761.L21SP2_0404	2.531e-05	53.0	2EUPK@1|root,33N5D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_322763_11	177437.HRM2_38480	1.507e-146	474.0	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,42NTX@68525|delta/epsilon subdivisions,2WMFG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	sarcosine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
CMS2_k127_322763_27	1047013.AQSP01000139_gene2366	5.853e-64	229.0	COG2227@1|root,COG2227@2|Bacteria,2NQ8I@2323|unclassified Bacteria	2|Bacteria	H	Methyltransferase domain	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS2_k127_322763_26	1047013.AQSP01000139_gene2365	1.541e-74	261.0	COG0382@1|root,COG0382@2|Bacteria	2|Bacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
CMS2_k127_322763_45	1047013.AQSP01000139_gene2364	1.772e-20	99.0	COG1285@1|root,COG1285@2|Bacteria,2NPSV@2323|unclassified Bacteria	2|Bacteria	S	MgtC family	mgtC	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
CMS2_k127_322763_34	1047013.AQSP01000139_gene2363	3.986e-48	179.0	COG0127@1|root,COG0127@2|Bacteria,2NPNJ@2323|unclassified Bacteria	2|Bacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66,5.1.1.3	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	-	R00260,R00426,R00720,R01855,R02100,R02720,R03531	RC00002,RC00302	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_1875	Ham1p_like
CMS2_k127_322763_41	215803.DB30_0397	1.015e-30	138.0	COG0739@1|root,COG3271@1|root,COG0739@2|Bacteria,COG3271@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K03791	-	-	-	-	ko00000	-	GH19	-	DUF4185,Peptidase_C39_2,Peptidase_C70,Peptidase_M23
CMS2_k127_322763_29	439235.Dalk_0237	3.432e-62	234.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_322763_48	272559.BF9343_4088	3.565e-08	57.0	COG0535@1|root,COG0535@2|Bacteria,4NR66@976|Bacteroidetes,2FT8U@200643|Bacteroidia,4ARDK@815|Bacteroidaceae	976|Bacteroidetes	S	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12
CMS2_k127_322763_44	706587.Desti_2898	4.239e-28	117.0	2APA5@1|root,31EC7@2|Bacteria,1RHMQ@1224|Proteobacteria,42UND@68525|delta/epsilon subdivisions,2WQK4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_322763_20	439235.Dalk_0237	1.363e-99	362.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_322763_51	1340493.JNIF01000003_gene3944	0.0002961	55.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
CMS2_k127_322763_39	1487923.DP73_02225	2.701e-38	167.0	COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia	186801|Clostridia	M	Competence protein ComEC	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Ada_Zn_binding,LTD,Lactamase_B
CMS2_k127_322763_5	665571.STHERM_c03590	3.736e-217	688.0	COG3044@1|root,COG3044@2|Bacteria	2|Bacteria	S	Predicted ATPase of the ABC class	-	-	-	-	-	-	-	-	-	-	-	-	ABC_ATPase
CMS2_k127_322763_46	1168067.JAGP01000001_gene1878	4.019e-15	79.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,460D0@72273|Thiotrichales	72273|Thiotrichales	E	Belongs to the UPF0758 family	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
CMS2_k127_322763_13	1379698.RBG1_1C00001G0343	9.942e-143	491.0	COG0286@1|root,COG0286@2|Bacteria	2|Bacteria	V	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_Mtase
CMS2_k127_322763_17	42256.RradSPS_3022	1.583e-132	442.0	COG0166@1|root,COG0166@2|Bacteria,2HFZ9@201174|Actinobacteria,4CPPV@84995|Rubrobacteria	84995|Rubrobacteria	G	Phosphoglucose isomerase	-	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
CMS2_k127_322763_43	290398.Csal_2788	2.211e-28	128.0	COG3613@1|root,COG3613@2|Bacteria,1NBEC@1224|Proteobacteria,1T3QJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	nucleoside 2-deoxyribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_322763_49	1246448.ANAZ01000024_gene2879	2.457e-06	59.0	COG1072@1|root,COG1072@2|Bacteria,2GIRR@201174|Actinobacteria,4EGC4@85012|Streptosporangiales	201174|Actinobacteria	H	Phosphoribulokinase / Uridine kinase family	coaA	GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
CMS2_k127_322763_36	1454004.AW11_01161	3.093e-46	188.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_322763_7	1047013.AQSP01000140_gene2494	8.899e-190	605.0	COG2234@1|root,COG2234@2|Bacteria,2NRCG@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
CMS2_k127_322763_42	1244869.H261_03113	1.246e-29	126.0	COG0500@1|root,COG2226@2|Bacteria,1RKQD@1224|Proteobacteria,2UAAJ@28211|Alphaproteobacteria,2JSQ3@204441|Rhodospirillales	204441|Rhodospirillales	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_322763_38	531844.FIC_00615	1.541e-40	160.0	2CRK8@1|root,32SP8@2|Bacteria,4NWA3@976|Bacteroidetes,1I5C7@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4253)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4253
CMS2_k127_322763_19	342610.Patl_3906	1.95e-109	362.0	COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,1S1KW@1236|Gammaproteobacteria,2Q5B8@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Beta-lactamase superfamily domain	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
CMS2_k127_322763_30	1191523.MROS_1240	3.864e-60	224.0	COG3104@1|root,COG3104@2|Bacteria	2|Bacteria	E	oligopeptide transport	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	MFS_1,PTR2
CMS2_k127_322763_33	1121403.AUCV01000030_gene2779	3.514e-52	191.0	COG0500@1|root,COG2226@2|Bacteria,1N3WC@1224|Proteobacteria,42URQ@68525|delta/epsilon subdivisions,2WQGW@28221|Deltaproteobacteria,2MKH6@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	FtsJ-like methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
CMS2_k127_322763_1	742766.HMPREF9455_03667	1.941e-241	775.0	COG1305@1|root,COG1305@2|Bacteria,4NFR8@976|Bacteroidetes,2FPAP@200643|Bacteroidia,22W3W@171551|Porphyromonadaceae	976|Bacteroidetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
CMS2_k127_322763_9	926569.ANT_03690	3.424e-154	496.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	3.4.11.10,3.4.11.24,3.4.11.6	ko:K19701,ko:K19702	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M28
CMS2_k127_3236546_0	720555.BATR1942_20430	0.0	1617.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	srfAB	-	-	ko:K15654,ko:K15655,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_3236546_2	1196323.ALKF01000205_gene4116	1.374e-275	955.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3236546_1	358681.BBR47_39840	7.35e-295	932.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HUE5@91061|Bacilli,26VP1@186822|Paenibacillaceae	91061|Bacilli	Q	Pfam:HxxPF_rpt	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Condensation,Methyltransf_12,NAD_binding_4,PP-binding
CMS2_k127_3245467_0	1499967.BAYZ01000116_gene3133	4.701e-28	132.0	COG0741@1|root,COG0741@2|Bacteria,2NPKN@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase SLT domain	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_16,TPR_6
CMS2_k127_325023_0	1122176.KB903576_gene5032	1.327e-154	522.0	COG2319@1|root,COG4995@1|root,COG2319@2|Bacteria,COG4995@2|Bacteria,4P49H@976|Bacteroidetes	976|Bacteroidetes	H	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
CMS2_k127_3251206_3	1007103.AFHW01000010_gene6121	5.081e-210	685.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15663,ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3251206_4	509191.AEDB02000067_gene916	1.799e-162	528.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_3251206_0	1237149.C900_01683	0.0	1975.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,4NDV5@976|Bacteroidetes,47K9U@768503|Cytophagia	976|Bacteroidetes	Q	Acyl transferase domain in polyketide synthase (PKS) enzymes.	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3251206_2	1195236.CTER_1456	6.131e-213	747.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_3251206_1	1173023.KE650771_gene5201	0.0	1380.0	COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,Thioesterase,ketoacyl-synt
CMS2_k127_3251206_5	717606.PaecuDRAFT_0070	5.425e-153	549.0	COG0318@1|root,COG0318@2|Bacteria,1UZQF@1239|Firmicutes,4ISPZ@91061|Bacilli,2776A@186822|Paenibacillaceae	91061|Bacilli	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,PP-binding
CMS2_k127_3251206_7	1536775.H70737_05270	5.737e-76	265.0	COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,4H9QD@91061|Bacilli,26TXN@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the carbamate kinase family	cpkA	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
CMS2_k127_3251206_6	880073.Calab_1140	5.869e-151	498.0	COG1164@1|root,COG1164@2|Bacteria,2NNVV@2323|unclassified Bacteria	2|Bacteria	E	Oligopeptidase F	pepF	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
CMS2_k127_3251206_8	1047013.AQSP01000140_gene2488	8.764e-12	70.0	COG4254@1|root,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
CMS2_k127_3259621_1	455632.SGR_2593	2.363e-147	480.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,41C4M@629295|Streptomyces griseus group	201174|Actinobacteria	E	Serine hydroxymethyltransferase	-	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
CMS2_k127_3259621_2	909613.UO65_4950	1.085e-18	87.0	COG3251@1|root,COG3251@2|Bacteria,2GQIK@201174|Actinobacteria,4ECQ2@85010|Pseudonocardiales	201174|Actinobacteria	S	MbtH-like protein	-	-	-	ko:K05375	ko00261,ko01130,map00261,map01130	M00736	R10880	RC00064,RC00141,RC03296,RC03297,RC03298	ko00000,ko00001,ko00002	-	-	-	MbtH
CMS2_k127_3259621_0	1173027.Mic7113_1748	6.003e-246	814.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H837@1150|Oscillatoriales	1117|Cyanobacteria	Q	Non-ribosomal peptide synthetase modules and related	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,PilZ
CMS2_k127_3262270_0	1121904.ARBP01000001_gene5513	9.401e-212	670.0	COG1012@1|root,COG1012@2|Bacteria,4NEKG@976|Bacteroidetes,47MQT@768503|Cytophagia	976|Bacteroidetes	C	PFAM Aldehyde dehydrogenase	aldH	-	1.2.1.26	ko:K13877	ko00040,ko00053,map00040,map00053	-	R00264	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
CMS2_k127_3262270_8	1121373.KB903629_gene362	1.455e-07	64.0	COG0457@1|root,COG0457@2|Bacteria	1121373.KB903629_gene362|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3262270_4	525904.Tter_0487	6.767e-60	214.0	COG0463@1|root,COG0463@2|Bacteria,2NS3Y@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
CMS2_k127_3262270_5	525904.Tter_0233	1.355e-58	216.0	COG2227@1|root,COG2227@2|Bacteria,2NQ8I@2323|unclassified Bacteria	2|Bacteria	H	Methyltransferase domain	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS2_k127_3262270_3	1047013.AQSP01000110_gene65	1.49e-87	305.0	COG1404@1|root,COG1404@2|Bacteria,2NP8X@2323|unclassified Bacteria	2|Bacteria	O	Subtilase family	apr	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
CMS2_k127_3262270_2	1047013.AQSP01000110_gene66	6.498e-93	325.0	COG0497@1|root,COG0497@2|Bacteria,2NNUS@2323|unclassified Bacteria	2|Bacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0000724,GO:0000725,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K03631,ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_23,SMC_N
CMS2_k127_3262270_1	1047013.AQSP01000110_gene72	8.465e-111	372.0	COG0621@1|root,COG0621@2|Bacteria,2NNUN@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
CMS2_k127_3262270_7	879212.DespoDRAFT_02518	8.566e-10	63.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.4.24.3	ko:K01387	-	-	-	-	ko00000,ko01000,ko01002,ko02042	-	-	-	PKD,Peptidase_M9,Peptidase_S8
CMS2_k127_3262270_6	497965.Cyan7822_5544	1.004e-15	79.0	COG0451@1|root,COG0451@2|Bacteria,1G2DP@1117|Cyanobacteria,3KJ9E@43988|Cyanothece	1117|Cyanobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
CMS2_k127_3267749_22	1237149.C900_04168	1.203e-28	134.0	COG3656@1|root,COG5563@1|root,COG3656@2|Bacteria,COG5563@2|Bacteria,4NHDQ@976|Bacteroidetes,47PJR@768503|Cytophagia	976|Bacteroidetes	G	Fibronectin type III domain protein	-	-	-	ko:K21571	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_3267749_21	1191523.MROS_2005	1.466e-32	146.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3267749_5	1173022.Cri9333_2867	5.304e-102	368.0	COG1331@1|root,COG1331@2|Bacteria	2|Bacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K20541	-	-	-	-	ko00000,ko02000	4.D.3.1.6	-	-	-
CMS2_k127_3267749_29	1313421.JHBV01000041_gene3465	1.695e-16	95.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Calx-beta,DUF4183,SLH,VCBS
CMS2_k127_3267749_11	592029.DDD_2273	6.398e-72	252.0	2EWJQ@1|root,33PXW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3267749_27	574087.Acear_2162	3.217e-22	107.0	2C678@1|root,32X5N@2|Bacteria	2|Bacteria	S	PFAM Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
CMS2_k127_3267749_25	65393.PCC7424_5869	1.148e-25	116.0	2CGDF@1|root,34388@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3267749_24	1121438.JNJA01000001_gene2233	7.424e-28	117.0	2CH0Y@1|root,3309M@2|Bacteria,1NF9M@1224|Proteobacteria,42VBP@68525|delta/epsilon subdivisions,2WRWS@28221|Deltaproteobacteria,2MB1U@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3267749_28	459495.SPLC1_S033600	2.503e-18	85.0	2EGPU@1|root,33AFZ@2|Bacteria,1G9QJ@1117|Cyanobacteria,1HD3U@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3267749_1	1232410.KI421412_gene220	3.853e-297	922.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,42N15@68525|delta/epsilon subdivisions,2WJ0Y@28221|Deltaproteobacteria,43U63@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS2_k127_3267749_4	517418.Ctha_2133	6.823e-155	497.0	COG0399@1|root,COG0399@2|Bacteria,1FEWK@1090|Chlorobi	1090|Chlorobi	H	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	2.6.1.33	ko:K20429	-	-	R02773	RC00006,RC00781	ko00000,ko01000	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_3267749_20	1292035.H476_0614	6.52e-33	136.0	COG0110@1|root,COG0110@2|Bacteria,1V8CV@1239|Firmicutes,24GND@186801|Clostridia	186801|Clostridia	GM	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family	-	-	-	ko:K19429	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep
CMS2_k127_3267749_10	909663.KI867150_gene1732	3.035e-77	269.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42NYX@68525|delta/epsilon subdivisions,2WJV8@28221|Deltaproteobacteria,2MRXC@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
CMS2_k127_3267749_31	351016.RAZWK3B_05822	4.665e-14	79.0	COG2246@1|root,COG2246@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	2.3.1.51,2.4.1.83	ko:K00655,ko:K00721	ko00510,ko00561,ko00564,ko01100,ko01110,map00510,map00561,map00564,map01100,map01110	M00089	R01009,R02241,R09381	RC00004,RC00005,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01003,ko01004	-	GT2	-	Glycos_transf_2,GtrA,Transglut_core
CMS2_k127_3267749_15	717231.Flexsi_0369	5.806e-49	185.0	COG1216@1|root,COG1216@2|Bacteria,2GGJU@200930|Deferribacteres	200930|Deferribacteres	S	COGs COG0463 Glycosyltransferase involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_3267749_26	555778.Hneap_0490	1.787e-24	121.0	2E96S@1|root,333FB@2|Bacteria,1ND0C@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3267749_8	1009370.ALO_18767	8.62e-85	314.0	COG0457@1|root,COG0457@2|Bacteria	1009370.ALO_18767|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3267749_7	489825.LYNGBM3L_28730	3.124e-95	322.0	COG0457@1|root,COG1196@1|root,COG1216@1|root,COG0457@2|Bacteria,COG1196@2|Bacteria,COG1216@2|Bacteria,1G1DS@1117|Cyanobacteria,1H8XW@1150|Oscillatoriales	1117|Cyanobacteria	D	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2
CMS2_k127_3267749_6	41431.PCC8801_0710	5.381e-97	328.0	COG0463@1|root,COG0463@2|Bacteria,1GQ5D@1117|Cyanobacteria	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_3267749_13	118168.MC7420_7338	3.497e-65	233.0	2DTTJ@1|root,32UVW@2|Bacteria,1G8TS@1117|Cyanobacteria,1HCTF@1150|Oscillatoriales	1117|Cyanobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
CMS2_k127_3267749_23	1301098.PKB_5491	1.298e-28	130.0	2E96S@1|root,333FB@2|Bacteria,1ND0C@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3267749_18	1232410.KI421412_gene252	2.523e-37	152.0	COG1215@1|root,COG1215@2|Bacteria,1QW0Y@1224|Proteobacteria,43BQU@68525|delta/epsilon subdivisions	1224|Proteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_3267749_9	1250005.PHEL85_1411	2.437e-82	288.0	COG0438@1|root,COG0438@2|Bacteria,4NK7K@976|Bacteroidetes,1I0M3@117743|Flavobacteriia	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
CMS2_k127_3267749_17	388413.ALPR1_09505	6.389e-38	152.0	29X85@1|root,30IXE@2|Bacteria,4PMKZ@976|Bacteroidetes,47T3S@768503|Cytophagia	976|Bacteroidetes	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
CMS2_k127_3267749_14	869213.JCM21142_52339	1.309e-53	199.0	COG1216@1|root,COG1216@2|Bacteria,4NIKM@976|Bacteroidetes,47M8F@768503|Cytophagia	976|Bacteroidetes	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_3267749_12	1300345.LF41_382	2.322e-65	231.0	COG0438@1|root,COG0438@2|Bacteria,1RJ7A@1224|Proteobacteria	1224|Proteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3267749_19	754476.Q7A_1432	1.189e-36	153.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_3267749_3	880073.Calab_3515	2.903e-211	672.0	COG0471@1|root,COG0471@2|Bacteria	2|Bacteria	P	metal ion transport	sac1	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	CitMHS,Na_sulph_symp,TrkA_C
CMS2_k127_3267749_0	1047013.AQSP01000103_gene1160	0.0	1007.0	COG1770@1|root,COG1770@2|Bacteria,2NNMF@2323|unclassified Bacteria	2|Bacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	ptrB	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
CMS2_k127_3267749_2	1304880.JAGB01000001_gene244	2.894e-234	752.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
CMS2_k127_3267749_30	517418.Ctha_0434	1.261e-15	79.0	COG5464@1|root,COG5464@2|Bacteria,1FESQ@1090|Chlorobi	1090|Chlorobi	S	PD-(D/E)XK nuclease family transposase	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_3307733_0	755731.Clo1100_2633	1.035e-151	497.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3321011_1	706587.Desti_1108	9.626e-138	446.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2MR87@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	pcmT	-	1.3.7.9	ko:K04108	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS2_k127_3321011_5	1125863.JAFN01000001_gene1570	1.186e-62	218.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,42S8R@68525|delta/epsilon subdivisions,2WNW6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CMS2_k127_3321011_8	706587.Desti_1106	9.497e-44	172.0	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,42RE0@68525|delta/epsilon subdivisions,2WQ47@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	CO dehydrogenase flavoprotein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
CMS2_k127_3321011_4	194439.CT0895	5.508e-87	295.0	COG0226@1|root,COG0226@2|Bacteria,1FF16@1090|Chlorobi	1090|Chlorobi	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
CMS2_k127_3321011_2	324925.Ppha_1681	2.09e-131	430.0	COG0573@1|root,COG0573@2|Bacteria,1FE1M@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstC	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
CMS2_k127_3321011_0	517417.Cpar_0920	8.963e-153	494.0	COG0581@1|root,COG0581@2|Bacteria,1FE3G@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
CMS2_k127_3321011_3	194439.CT0899	1.527e-117	384.0	COG1117@1|root,COG1117@2|Bacteria,1FEDI@1090|Chlorobi	1090|Chlorobi	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
CMS2_k127_3321011_6	880073.Calab_2875	9.131e-60	214.0	COG0704@1|root,COG0704@2|Bacteria,2NPWX@2323|unclassified Bacteria	2|Bacteria	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
CMS2_k127_3321011_7	694427.Palpr_0030	4.671e-46	167.0	COG3752@1|root,COG3752@2|Bacteria,4NJXA@976|Bacteroidetes,2FWRU@200643|Bacteroidia	976|Bacteroidetes	S	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
CMS2_k127_33222_9	930945.SiRe_0435	1.082e-17	94.0	COG2301@1|root,arCOG00760@2157|Archaea,2XQ9T@28889|Crenarchaeota	28889|Crenarchaeota	G	C-C_Bond_Lyase of the TIM-Barrel fold	mcl	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
CMS2_k127_33222_12	257313.BP3273	1.772e-05	56.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,3T1HY@506|Alcaligenaceae	28216|Betaproteobacteria	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
CMS2_k127_33222_5	1191523.MROS_2005	5.437e-92	345.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_33222_13	1239962.C943_03571	0.0004043	55.0	COG4412@1|root,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Cellulase,DUF4859,F5_F8_type_C
CMS2_k127_33222_10	1121904.ARBP01000002_gene6675	2.149e-11	79.0	COG3209@1|root,COG3420@1|root,COG5644@1|root,COG3209@2|Bacteria,COG3420@2|Bacteria,COG5644@2|Bacteria,4PKBQ@976|Bacteroidetes	976|Bacteroidetes	M	SPTR CHU large protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11,SprB
CMS2_k127_33222_2	247490.KSU1_C0714	3.711e-156	551.0	COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes	203682|Planctomycetes	O	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
CMS2_k127_33222_6	313612.L8106_30180	1.56e-44	189.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G1QI@1117|Cyanobacteria,1H6XA@1150|Oscillatoriales	1117|Cyanobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,NB-ARC,TIR_2,TPR_10,TPR_12,TPR_7,TPR_8
CMS2_k127_33222_4	1185876.BN8_04256	3.116e-97	342.0	COG0296@1|root,COG1680@1|root,COG0296@2|Bacteria,COG1680@2|Bacteria,4NG6Z@976|Bacteroidetes,47PR8@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Beta-lactamase
CMS2_k127_33222_0	1242864.D187_004712	9.435e-248	773.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2YU6I@29|Myxococcales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	pccB	-	2.1.3.1,2.1.3.15,6.4.1.3	ko:K01966,ko:K17489	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R00353,R01859	RC00040,RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
CMS2_k127_33222_1	639282.DEFDS_1227	1.4e-165	535.0	COG0439@1|root,COG0439@2|Bacteria,2GEJU@200930|Deferribacteres	200930|Deferribacteres	I	Pfam:CPSase_L_chain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
CMS2_k127_33222_8	926550.CLDAP_21640	3.465e-22	104.0	COG4770@1|root,COG4770@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	pccA	-	6.4.1.3	ko:K01965,ko:K02160	ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00373,M00376,M00741	R00742,R01859	RC00040,RC00097,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
CMS2_k127_33222_11	1121923.GPUN_1241	3.583e-06	59.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,464AD@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	GO:0003674,GO:0003824,GO:0004366,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006629,GO:0006631,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0031224,GO:0031226,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iECs_1301.ECs5024,iG2583_1286.G2583_4866	Acyltransferase
CMS2_k127_33222_3	679926.Mpet_1272	3.772e-114	388.0	COG1032@1|root,arCOG04984@2157|Archaea,2XUS3@28890|Euryarchaeota,2N97H@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
CMS2_k127_3330697_5	1262914.BN533_00011	3.859e-30	131.0	2E5DD@1|root,3305D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3330697_1	608538.HTH_0269	1.658e-156	504.0	COG1215@1|root,COG1215@2|Bacteria,2G4H2@200783|Aquificae	200783|Aquificae	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
CMS2_k127_3330697_6	608538.HTH_0270	1.339e-13	83.0	COG1664@1|root,COG1664@2|Bacteria,2G5A1@200783|Aquificae	200783|Aquificae	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3330697_4	1262914.BN533_00007	2.603e-38	156.0	COG3408@1|root,COG3408@2|Bacteria,1UZR0@1239|Firmicutes	1239|Firmicutes	G	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3330697_0	608538.HTH_0271	7.935e-161	526.0	COG0726@1|root,COG0726@2|Bacteria,2G4NT@200783|Aquificae	200783|Aquificae	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3330697_3	1262914.BN533_00007	3.764e-47	183.0	COG3408@1|root,COG3408@2|Bacteria,1UZR0@1239|Firmicutes	1239|Firmicutes	G	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3330697_7	195250.CM001776_gene2219	2.59e-05	56.0	COG0381@1|root,COG0381@2|Bacteria,1G0BY@1117|Cyanobacteria,1GZ1C@1129|Synechococcus	1117|Cyanobacteria	G	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	nfrC	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
CMS2_k127_3330697_2	608538.HTH_0267	8.996e-50	187.0	2E6HX@1|root,307WJ@2|Bacteria,2G4Y0@200783|Aquificae	200783|Aquificae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3330697_8	316274.Haur_0691	0.0004812	53.0	COG2304@1|root,COG2304@2|Bacteria,2GACU@200795|Chloroflexi,375FC@32061|Chloroflexia	32061|Chloroflexia	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
CMS2_k127_3343449_0	349520.PPE_03011	0.0	3182.0	COG2227@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	pksR	-	-	ko:K13613,ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_3358007_0	502025.Hoch_1667	1.038e-141	487.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_3358007_2	351160.LRC151	8.704e-13	83.0	COG3291@1|root,arCOG02510@2157|Archaea	2157|Archaea	O	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_6,DUF3344,NHL,NosD,PKD,SBBP
CMS2_k127_3358007_1	1237149.C900_05552	1.321e-61	242.0	COG3227@1|root,COG3291@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,4NJK3@976|Bacteroidetes,47TYM@768503|Cytophagia	976|Bacteroidetes	E	Pregnancy-associated plasma protein-A	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_M43,fn3
CMS2_k127_3358108_2	394503.Ccel_2386	5.813e-175	586.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3358108_1	509191.AEDB02000067_gene916	3.195e-199	636.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_3358108_0	1121121.KB894285_gene80	0.0	1233.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15662	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3363284_1	324057.Pjdr2_0698	0.0005583	51.0	COG3170@1|root,COG4099@1|root,COG4932@1|root,COG3170@2|Bacteria,COG4099@2|Bacteria,COG4932@2|Bacteria,1UJE7@1239|Firmicutes,4IT6J@91061|Bacilli,2778B@186822|Paenibacillaceae	91061|Bacilli	M	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,SLH
CMS2_k127_3363284_0	1254432.SCE1572_29990	1.827e-23	119.0	COG0739@1|root,COG2373@1|root,COG0739@2|Bacteria,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,Peptidase_M23,PhageMin_Tail,SLT_2
CMS2_k127_3372834_0	1047013.AQSP01000123_gene1522	1.344e-46	181.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_3372834_1	1122915.AUGY01000080_gene3254	4.491e-32	134.0	COG1680@1|root,COG1680@2|Bacteria,1TR9E@1239|Firmicutes,4HER8@91061|Bacilli,26S99@186822|Paenibacillaceae	91061|Bacilli	V	Beta-lactamase class C and other penicillin binding	M1-750	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_3380568_0	697284.ERIC2_c18050	0.0	1659.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3402766_1	63737.Npun_F2181	0.0	1219.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_3402766_0	1042163.BRLA_c025650	0.0	1818.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15662	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3402766_3	1392488.JHZY01000004_gene3199	3.497e-11	68.0	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,1HXUN@117743|Flavobacteriia,2XJXN@283735|Leeuwenhoekiella	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_3402766_4	743719.PaelaDRAFT_3029	1.402e-08	61.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V2XC@1239|Firmicutes,4HGEC@91061|Bacilli,26WPU@186822|Paenibacillaceae	91061|Bacilli	K	helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
CMS2_k127_3402766_2	545696.HOLDEFILI_01311	1.79e-11	68.0	COG2207@1|root,COG2207@2|Bacteria,1VF0G@1239|Firmicutes,3VUG8@526524|Erysipelotrichia	526524|Erysipelotrichia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
CMS2_k127_3418310_1	313606.M23134_03762	5.707e-21	97.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
CMS2_k127_3418310_0	926556.Echvi_1013	4.766e-184	588.0	COG0783@1|root,COG3039@1|root,COG0783@2|Bacteria,COG3039@2|Bacteria,4NI06@976|Bacteroidetes,47WK3@768503|Cytophagia	976|Bacteroidetes	LP	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF772
CMS2_k127_3446918_12	1379698.RBG1_1C00001G1218	6.394e-45	174.0	COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria	2|Bacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_8
CMS2_k127_3446918_29	1449338.JQLU01000005_gene3450	0.0001694	54.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	ko:K08777	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FHA
CMS2_k127_3446918_27	5888.CAK66429	3.322e-09	70.0	KOG0586@1|root,KOG0586@2759|Eukaryota,3ZFTW@5878|Ciliophora	2759|Eukaryota	T	Protein tyrosine kinase	-	-	2.7.11.1,2.7.11.17	ko:K08794,ko:K08798,ko:K08802,ko:K13412	ko04626,ko04921,ko04925,ko05145,map04626,map04921,map04925,map05145	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04812	-	-	-	Pkinase
CMS2_k127_3446918_1	243231.GSU1250	1.221e-162	525.0	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42NMK@68525|delta/epsilon subdivisions,2WK6K@28221|Deltaproteobacteria,43U00@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_3446918_6	269799.Gmet_1083	2.364e-93	326.0	COG2202@1|root,COG3290@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3290@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
CMS2_k127_3446918_15	582515.KR51_00013110	6.091e-33	145.0	COG0784@1|root,COG0784@2|Bacteria,1G85J@1117|Cyanobacteria	1117|Cyanobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_3446918_14	247490.KSU1_C0709	3.25e-39	151.0	COG1633@1|root,COG1633@2|Bacteria,2J3M5@203682|Planctomycetes	203682|Planctomycetes	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_3446918_11	1047013.AQSP01000130_gene1877	6.251e-51	190.0	COG1711@1|root,COG1711@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3014
CMS2_k127_3446918_9	246197.MXAN_5776	2.384e-79	277.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2YUJQ@29|Myxococcales	28221|Deltaproteobacteria	NU	pilus assembly protein	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
CMS2_k127_3446918_21	1047013.AQSP01000124_gene2679	2.415e-20	99.0	COG3166@1|root,COG3166@2|Bacteria,2NRP1@2323|unclassified Bacteria	2|Bacteria	NU	Fimbrial assembly protein (PilN)	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
CMS2_k127_3446918_20	1047013.AQSP01000124_gene2678	1.571e-20	99.0	COG3167@1|root,COG3167@2|Bacteria,2NPUF@2323|unclassified Bacteria	2|Bacteria	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
CMS2_k127_3446918_2	1047013.AQSP01000124_gene2676	8.657e-129	444.0	COG4796@1|root,COG4796@2|Bacteria,2NPEQ@2323|unclassified Bacteria	2|Bacteria	U	Secretin and TonB N terminus short domain	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
CMS2_k127_3446918_24	1296415.JACC01000027_gene1316	1.316e-13	84.0	COG3210@1|root,COG3250@1|root,COG3420@1|root,COG5297@1|root,COG3210@2|Bacteria,COG3250@2|Bacteria,COG3420@2|Bacteria,COG5297@2|Bacteria,4NPFX@976|Bacteroidetes,1IIJZ@117743|Flavobacteriia	976|Bacteroidetes	GPU	Putative binding domain, N-terminal	-	-	4.2.2.3	ko:K01729	ko00051,map00051	-	R03706	-	ko00000,ko00001,ko01000	-	-	-	BACON,Chondroitinas_B,F5_F8_type_C
CMS2_k127_3446918_28	7222.FBpp0156631	3.323e-05	55.0	COG0457@1|root,KOG2579@1|root,KOG2002@2759|Eukaryota,KOG2579@2759|Eukaryota,38B9I@33154|Opisthokonta,3BGZH@33208|Metazoa,3CRQF@33213|Bilateria,41VWF@6656|Arthropoda,3SJFD@50557|Insecta,44XT1@7147|Diptera,45XRY@7214|Drosophilidae	33208|Metazoa	P	Tetratricopeptide repeat	-	GO:0000428,GO:0000785,GO:0000993,GO:0001098,GO:0001099,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006355,GO:0006357,GO:0008023,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016591,GO:0016593,GO:0019219,GO:0019222,GO:0019899,GO:0019904,GO:0030880,GO:0031056,GO:0031060,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031399,GO:0031974,GO:0031981,GO:0032268,GO:0032991,GO:0033043,GO:0033044,GO:0035327,GO:0042169,GO:0043175,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044464,GO:0044877,GO:0045893,GO:0045935,GO:0045944,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051173,GO:0051246,GO:0051252,GO:0051254,GO:0051569,GO:0055029,GO:0060255,GO:0061695,GO:0065007,GO:0070013,GO:0070063,GO:0080090,GO:1902275,GO:1902494,GO:1902680,GO:1903506,GO:1903508,GO:1990234,GO:2000112,GO:2001141	-	ko:K15176	-	-	-	-	ko00000,ko03021	-	-	-	TPR_12,TPR_16,TPR_8
CMS2_k127_3446918_8	1047013.AQSP01000123_gene1521	2.102e-79	293.0	COG1629@1|root,COG4771@2|Bacteria,2NRBR@2323|unclassified Bacteria	2|Bacteria	P	TonB dependent receptor	-	-	-	ko:K02014,ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.2	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
CMS2_k127_3446918_7	1047013.AQSP01000034_gene1655	2.578e-89	308.0	COG0012@1|root,COG0012@2|Bacteria,2NNNF@2323|unclassified Bacteria	2|Bacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
CMS2_k127_3446918_3	1408473.JHXO01000007_gene967	1.424e-119	394.0	COG1443@1|root,COG1443@2|Bacteria,4NJUP@976|Bacteroidetes,2FNMR@200643|Bacteroidia	976|Bacteroidetes	I	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	IspA,NUDIX
CMS2_k127_3446918_13	1122173.AXVL01000026_gene1935	3.752e-43	169.0	COG1216@1|root,COG1216@2|Bacteria,37CEG@32066|Fusobacteria	32066|Fusobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_3446918_23	351160.RCIX759	6.31e-14	80.0	COG0500@1|root,arCOG01776@2157|Archaea	2157|Archaea	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_3446918_18	1047013.AQSP01000135_gene1570	8.757e-22	101.0	COG1399@1|root,COG1399@2|Bacteria,2NPVD@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized ACR, COG1399	yceD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
CMS2_k127_3446918_22	1047013.AQSP01000135_gene1569	3.676e-19	87.0	COG0333@1|root,COG0333@2|Bacteria,2NQ1M@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal L32p protein family	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
CMS2_k127_3446918_4	1047013.AQSP01000135_gene1568	3.33e-98	332.0	COG0416@1|root,COG0416@2|Bacteria,2NP1H@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.21.4.2,1.21.4.3,1.21.4.4,2.3.1.15	ko:K03621,ko:K21576,ko:K21577	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
CMS2_k127_3446918_5	880073.Calab_0618	2.85e-97	323.0	COG1028@1|root,COG1028@2|Bacteria,2NP35@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS2_k127_3446918_17	1047013.AQSP01000135_gene1566	8.355e-24	102.0	COG0236@1|root,COG0236@2|Bacteria,2NPVJ@2323|unclassified Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CMS2_k127_3446918_0	1158338.JNLJ01000001_gene883	2.867e-164	526.0	COG0304@1|root,COG0304@2|Bacteria,2G3SR@200783|Aquificae	200783|Aquificae	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS2_k127_3446918_19	457570.Nther_1313	2.185e-21	103.0	COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,248TD@186801|Clostridia	186801|Clostridia	L	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
CMS2_k127_3446918_26	290512.Paes_1915	1.887e-09	70.0	COG1572@1|root,COG1572@2|Bacteria,1FEDB@1090|Chlorobi	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
CMS2_k127_3446918_10	1499967.BAYZ01000156_gene556	1.403e-72	250.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K20444	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS2_k127_3449793_0	324925.Ppha_2192	1.116e-233	755.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,1FEK9@1090|Chlorobi	1090|Chlorobi	T	NACHT nucleoside triphosphatase	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,NACHT
CMS2_k127_3449793_1	324925.Ppha_1553	6.549e-232	750.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,1FEK9@1090|Chlorobi	1090|Chlorobi	T	NACHT nucleoside triphosphatase	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,NACHT
CMS2_k127_3449793_4	324925.Ppha_2191	1.569e-43	161.0	2DMHJ@1|root,32RM0@2|Bacteria,1FFJV@1090|Chlorobi	1090|Chlorobi	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
CMS2_k127_3449793_2	324925.Ppha_2189	3.117e-136	442.0	COG3344@1|root,COG3344@2|Bacteria,1FEDC@1090|Chlorobi	1090|Chlorobi	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
CMS2_k127_3449793_3	1521187.JPIM01000099_gene41	5.998e-66	230.0	COG0512@1|root,COG0512@2|Bacteria,2G69G@200795|Chloroflexi,376BZ@32061|Chloroflexia	32061|Chloroflexia	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
CMS2_k127_3449793_5	1123288.SOV_1c07780	5.409e-15	81.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,4H6Y8@909932|Negativicutes	909932|Negativicutes	EH	Anthranilate synthase component I, N terminal region	-	-	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
CMS2_k127_347219_0	536232.CLM_0373	1.421e-252	824.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_347219_2	289376.THEYE_A1734	3.671e-42	179.0	COG0476@1|root,COG0476@2|Bacteria	2|Bacteria	H	Involved in molybdopterin and thiamine biosynthesis, family 2	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
CMS2_k127_347219_1	163908.KB235896_gene3938	7.994e-128	442.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3479142_1	1237149.C900_00684	1.949e-19	93.0	COG3209@1|root,COG4733@1|root,COG4886@1|root,COG3209@2|Bacteria,COG4733@2|Bacteria,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase,Big_2,DUF4988,He_PIG
CMS2_k127_3479142_3	35754.JNYJ01000010_gene1726	0.0002336	46.0	2CDDK@1|root,302H0@2|Bacteria,2GQAA@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3479142_0	931626.Awo_c14310	3.648e-80	283.0	COG2801@1|root,COG2801@2|Bacteria,1TQH6@1239|Firmicutes,249ZV@186801|Clostridia,25VV0@186806|Eubacteriaceae	186801|Clostridia	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
CMS2_k127_3479142_2	246194.CHY_2519	1.864e-16	82.0	COG3267@1|root,COG3267@2|Bacteria,1TRGM@1239|Firmicutes,25D5K@186801|Clostridia,42JFB@68295|Thermoanaerobacterales	186801|Clostridia	U	transposase gene. There are two copies of the ISChy3 element in this genome	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
CMS2_k127_3514649_15	944480.ATUV01000001_gene1257	2.136e-41	164.0	COG5464@1|root,COG5464@2|Bacteria,1MUSP@1224|Proteobacteria,42RIE@68525|delta/epsilon subdivisions,2WNU1@28221|Deltaproteobacteria,2M7M5@213113|Desulfurellales	28221|Deltaproteobacteria	S	Putative transposase, YhgA-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
CMS2_k127_3514649_22	525904.Tter_0083	4.849e-11	77.0	COG0457@1|root,COG5635@1|root,COG0457@2|Bacteria,COG5635@2|Bacteria,2NPK1@2323|unclassified Bacteria	2|Bacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,NACHT,SIR2_2,TPR_1,TPR_11,TPR_2,TPR_8
CMS2_k127_3514649_0	269799.Gmet_1637	1.383e-320	997.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	malic protein domain protein	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
CMS2_k127_3514649_17	1304275.C41B8_18231	9.166e-28	115.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	RNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS2_k127_3514649_8	1121403.AUCV01000009_gene1447	9.616e-84	291.0	2CCYB@1|root,2Z88J@2|Bacteria,1RA8X@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3514649_21	1304284.L21TH_2146	1.612e-17	86.0	COG0857@1|root,COG0857@2|Bacteria,1VEWN@1239|Firmicutes,24QW9@186801|Clostridia,36MIJ@31979|Clostridiaceae	186801|Clostridia	C	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
CMS2_k127_3514649_11	1209989.TepiRe1_2041	2.162e-54	202.0	COG2172@1|root,COG2172@2|Bacteria,1V6YP@1239|Firmicutes,24JJ0@186801|Clostridia,42GXK@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM ATP-binding region, ATPase domain protein	RsbW	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2
CMS2_k127_3514649_9	1209989.TepiRe1_2040	7.429e-81	285.0	COG2000@1|root,COG2221@1|root,COG4624@1|root,COG2000@2|Bacteria,COG2221@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,24BF5@186801|Clostridia,42F1E@68295|Thermoanaerobacterales	186801|Clostridia	C	Fe-S cluster domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,Fer4_9
CMS2_k127_3514649_13	1047013.AQSP01000091_gene641	5.649e-44	165.0	COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS2_k127_3514649_19	457415.HMPREF1006_00789	1.775e-25	111.0	COG4109@1|root,COG4109@2|Bacteria,3TBCK@508458|Synergistetes	508458|Synergistetes	K	PFAM DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
CMS2_k127_3514649_14	385682.AFSL01000064_gene1708	1.446e-43	163.0	COG2172@1|root,COG2172@2|Bacteria,4NRAS@976|Bacteroidetes,2FT57@200643|Bacteroidia,3XK5B@558415|Marinilabiliaceae	976|Bacteroidetes	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2
CMS2_k127_3514649_6	1304284.L21TH_2147	5.918e-104	352.0	COG2000@1|root,COG2221@1|root,COG4624@1|root,COG2000@2|Bacteria,COG2221@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,24BF5@186801|Clostridia,36E2Y@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,Fer4_9
CMS2_k127_3514649_18	1009370.ALO_07878	1.13e-27	116.0	COG4109@1|root,COG4109@2|Bacteria,1UK26@1239|Firmicutes,4H57E@909932|Negativicutes	909932|Negativicutes	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
CMS2_k127_3514649_10	644282.Deba_1522	4.022e-62	222.0	COG0613@1|root,COG0613@2|Bacteria,1N68X@1224|Proteobacteria,42TYN@68525|delta/epsilon subdivisions,2WR34@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PHP-associated	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP_C
CMS2_k127_3514649_12	706587.Desti_2750	2.529e-45	170.0	COG4191@1|root,COG4191@2|Bacteria,1N4YV@1224|Proteobacteria,42UJD@68525|delta/epsilon subdivisions,2WR5P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
CMS2_k127_3514649_16	644282.Deba_1520	2.932e-34	135.0	COG3411@1|root,COG3411@2|Bacteria,1N1N9@1224|Proteobacteria,42U7G@68525|delta/epsilon subdivisions,2WQFG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Ferredoxin	-	-	1.12.1.3	ko:K17992	-	-	-	-	ko00000,ko01000	-	-	-	-
CMS2_k127_3514649_1	555079.Toce_0696	9.696e-268	837.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42EM7@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
CMS2_k127_3514649_3	909663.KI867150_gene399	1.626e-142	481.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MR16@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase, Fe4S4	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
CMS2_k127_3514649_7	909663.KI867150_gene398	1.956e-99	331.0	COG0543@1|root,COG0543@2|Bacteria,1NTWI@1224|Proteobacteria,42M66@68525|delta/epsilon subdivisions,2WJJ2@28221|Deltaproteobacteria,2MRSB@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	nfnB	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
CMS2_k127_3514649_2	909663.KI867150_gene397	2.155e-217	683.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria,2MREN@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM glutamate synthase (NADPH), homotetrameric	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
CMS2_k127_3514649_5	1168065.DOK_19075	1.685e-107	361.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	mntH	-	-	-	-	-	-	-	-	-	-	-	Nramp
CMS2_k127_3514649_23	536232.CLM_0239	0.0001477	46.0	2CC4I@1|root,2Z8PZ@2|Bacteria,1TQTT@1239|Firmicutes,24AJ3@186801|Clostridia,36F6T@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3514661_0	555779.Dthio_PD0699	3.937e-159	509.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,42MFI@68525|delta/epsilon subdivisions,2WKXD@28221|Deltaproteobacteria,2MAH6@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_3515128_1	746697.Aeqsu_1674	1.218e-23	118.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,4NHCZ@976|Bacteroidetes,1HXNK@117743|Flavobacteriia	976|Bacteroidetes	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_8
CMS2_k127_3515128_2	991905.SL003B_1441	5.071e-06	50.0	2EX9Y@1|root,33QKN@2|Bacteria,1NQMW@1224|Proteobacteria,2UNVW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3515128_0	399550.Smar_0449	1.371e-58	208.0	COG1042@1|root,arCOG01340@2157|Archaea,2XPR9@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	CoA_binding_2,Succ_CoA_lig
CMS2_k127_351814_1	498211.CJA_3310	2.162e-11	73.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RSE7@1236|Gammaproteobacteria,1FG5F@10|Cellvibrio	1236|Gammaproteobacteria	M	TIGRFAM YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS,RHS_repeat
CMS2_k127_351814_0	439235.Dalk_0237	4.693e-102	366.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_3522908_0	386456.JQKN01000004_gene176	2.436e-75	279.0	COG0642@1|root,COG0784@1|root,arCOG02333@2157|Archaea,arCOG02358@2157|Archaea	2157|Archaea	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA,HisKA_4TM,PAS,PAS_3,PAS_4,PAS_9,Response_reg
CMS2_k127_3522908_4	32057.KB217478_gene6531	2.398e-29	136.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
CMS2_k127_3522908_2	177437.HRM2_33850	2.385e-69	248.0	2AHJ8@1|root,317WV@2|Bacteria,1PZDF@1224|Proteobacteria,435WU@68525|delta/epsilon subdivisions,2X0D7@28221|Deltaproteobacteria,2MP58@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3522908_3	96561.Dole_2945	5.204e-34	138.0	2FI53@1|root,349XT@2|Bacteria,1P0KG@1224|Proteobacteria,431XV@68525|delta/epsilon subdivisions,2WW9F@28221|Deltaproteobacteria,2MP20@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3522908_5	373903.Hore_07310	3.363e-16	80.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,3WAV0@53433|Halanaerobiales	186801|Clostridia	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
CMS2_k127_3556691_1	1237149.C900_03948	3.542e-34	134.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
CMS2_k127_3556691_0	1121904.ARBP01000030_gene1933	5.464e-156	524.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47JJN@768503|Cytophagia	976|Bacteroidetes	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS2_k127_356625_0	509191.AEDB02000067_gene921	4.706e-238	761.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3579107_15	269797.Mbar_A2759	3.107e-53	202.0	COG0265@1|root,arCOG02833@2157|Archaea	2157|Archaea	O	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Trypsin_2
CMS2_k127_3579107_31	760192.Halhy_6807	5.135e-05	49.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,AAA_16,AAA_22,AAA_35,ATPase_2,TniB
CMS2_k127_3579107_19	760192.Halhy_6807	5.22e-25	112.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,AAA_16,AAA_22,AAA_35,ATPase_2,TniB
CMS2_k127_3579107_28	1499967.BAYZ01000011_gene5211	1.208e-08	60.0	COG2952@1|root,COG2952@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF507)	-	-	-	ko:K09804	-	-	-	-	ko00000	-	-	-	DUF507
CMS2_k127_3579107_25	1047013.AQSP01000110_gene81	1.102e-16	83.0	COG2952@1|root,COG2952@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF507)	-	-	-	ko:K09804	-	-	-	-	ko00000	-	-	-	DUF507
CMS2_k127_3579107_6	626887.J057_19280	4.306e-153	496.0	COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,464YM@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494	1.6.5.8	ko:K00346	-	-	-	-	ko00000,ko01000	-	-	-	NQRA,NQRA_SLBB
CMS2_k127_3579107_5	1353529.M899_2370	3.143e-162	520.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,42MTU@68525|delta/epsilon subdivisions,2WKN8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrB	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
CMS2_k127_3579107_14	675814.VIC_000691	2.497e-64	229.0	COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria,1XUPV@135623|Vibrionales	135623|Vibrionales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
CMS2_k127_3579107_11	1278307.KB906968_gene2096	5.551e-88	294.0	COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,2QHUE@267894|Psychromonadaceae	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrD	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030001,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
CMS2_k127_3579107_9	1353529.M899_2367	7.867e-94	311.0	COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,42N3Q@68525|delta/epsilon subdivisions,2WJSA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrE	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
CMS2_k127_3579107_3	1286106.MPL1_01647	3.034e-193	610.0	COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,461R6@72273|Thiotrichales	72273|Thiotrichales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway	nqrF	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
CMS2_k127_3579107_10	589873.EP13_16285	7.34e-93	316.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,46547@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016740,GO:0017013,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0031975,GO:0036094,GO:0036211,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:0098552,GO:0098567,GO:1901265,GO:1901363,GO:1901564	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
CMS2_k127_3579107_30	575540.Isop_0308	9.522e-06	52.0	COG0662@1|root,COG0662@2|Bacteria,2J0CV@203682|Planctomycetes	203682|Planctomycetes	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS2_k127_3579107_8	1267535.KB906767_gene3473	4.514e-117	411.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,3Y2FS@57723|Acidobacteria,2JKCS@204432|Acidobacteriia	204432|Acidobacteriia	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3,Reg_prop,Y_Y_Y
CMS2_k127_3579107_20	1121007.AUML01000003_gene2527	9.889e-25	122.0	COG2207@1|root,COG2207@2|Bacteria,4NKKA@976|Bacteroidetes,1HX54@117743|Flavobacteriia,2YHTZ@290174|Aquimarina	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS2_k127_3579107_4	509191.AEDB02000067_gene921	1.191e-181	583.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3579107_7	1121121.KB894288_gene2762	2.291e-125	411.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HB0J@91061|Bacilli,26QCJ@186822|Paenibacillaceae	91061|Bacilli	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS2_k127_3579107_21	1121121.KB894288_gene2761	4.741e-22	98.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
CMS2_k127_3579107_17	1047013.AQSP01000098_gene2565	1.022e-37	157.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	ko:K05385	ko00196,ko01100,map00196,map01100	-	-	-	ko00000,ko00001,ko00194	-	-	-	HEAT_2
CMS2_k127_3579107_18	1267534.KB906760_gene1385	5.29e-26	117.0	COG1413@1|root,COG1413@2|Bacteria,3Y76M@57723|Acidobacteria,2JM4Z@204432|Acidobacteriia	204432|Acidobacteriia	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
CMS2_k127_3579107_1	243231.GSU2860	1.971e-257	810.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS2_k127_3579107_16	1144275.COCOR_05081	3.712e-50	188.0	COG0300@1|root,COG0300@2|Bacteria,1NRK7@1224|Proteobacteria	1224|Proteobacteria	S	KR domain	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
CMS2_k127_3579107_13	945713.IALB_1857	6.894e-77	286.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbU	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,GAF_3,SpoIIE
CMS2_k127_3579107_27	761193.Runsl_2852	1.175e-10	72.0	2CM2H@1|root,32SDI@2|Bacteria,4NSAF@976|Bacteroidetes,47R71@768503|Cytophagia	976|Bacteroidetes	S	Putative lumazine-binding	-	-	-	-	-	-	-	-	-	-	-	-	Lumazine_bd_2
CMS2_k127_3579107_26	1163409.UUA_15106	3.264e-13	80.0	2CM2H@1|root,32SDI@2|Bacteria,1NPEY@1224|Proteobacteria,1TH36@1236|Gammaproteobacteria,1XAW5@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3579107_29	446462.Amir_3895	1.809e-06	59.0	COG1210@1|root,COG1210@2|Bacteria,2IA2Z@201174|Actinobacteria,4E27B@85010|Pseudonocardiales	201174|Actinobacteria	M	Utp--glucose-1-phosphate uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3579107_23	1499689.CCNN01000007_gene2632	1.155e-19	99.0	COG1216@1|root,COG1216@2|Bacteria,1TSTE@1239|Firmicutes,249WH@186801|Clostridia,36E4U@31979|Clostridiaceae	186801|Clostridia	M	glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
CMS2_k127_3579107_22	289376.THEYE_A1273	1.032e-19	91.0	COG2331@1|root,COG2331@2|Bacteria,3J0V8@40117|Nitrospirae	40117|Nitrospirae	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
CMS2_k127_3579107_24	672.VV93_v1c14550	9.718e-17	83.0	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria,1XYDK@135623|Vibrionales	135623|Vibrionales	C	COG1254 Acylphosphatases	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
CMS2_k127_3579107_2	709991.Odosp_2160	8.751e-223	702.0	COG4231@1|root,COG4231@2|Bacteria,4NJM1@976|Bacteroidetes,2FMYS@200643|Bacteroidia,22X57@171551|Porphyromonadaceae	976|Bacteroidetes	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR_N,TPP_enzyme_C
CMS2_k127_3579107_12	1408473.JHXO01000004_gene77	4.589e-79	268.0	COG1014@1|root,COG1014@2|Bacteria,4NGN3@976|Bacteroidetes,2FP78@200643|Bacteroidia	976|Bacteroidetes	C	COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
CMS2_k127_3579107_0	1274524.BSONL12_02557	0.0	1800.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	ko:K16095	ko01054,map01054	-	-	-	ko00000,ko00001	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
CMS2_k127_3585388_3	118005.AWNK01000004_gene1064	4.764e-296	992.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3585388_7	1121121.KB894288_gene2765	3.161e-113	416.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_3585388_2	398512.JQKC01000009_gene568	0.0	1217.0	COG1020@1|root,COG1020@2|Bacteria,1V12Q@1239|Firmicutes,24ER3@186801|Clostridia,3WNBS@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,PP-binding,QueC,Radical_SAM
CMS2_k127_3585388_1	63737.Npun_R3425	0.0	1376.0	COG1028@1|root,COG3319@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3319@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1HJVE@1161|Nostocales	1117|Cyanobacteria	Q	COGs COG3321 Polyketide synthase modules and related protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3585388_6	1209072.ALBT01000007_gene2793	3.726e-152	517.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1FHSS@10|Cellvibrio	1236|Gammaproteobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3585388_5	509191.AEDB02000067_gene916	4.417e-163	531.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_3585388_4	1501230.ET33_30840	4.901e-251	812.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Glyoxalase_4,Methyltransf_31,PP-binding,Thioesterase
CMS2_k127_3585388_0	755731.Clo1100_2632	0.0	2008.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3585388_9	63737.Npun_R3025	1.846e-34	141.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3585388_8	330214.NIDE2150	2.555e-79	269.0	COG0318@1|root,COG1020@1|root,COG4122@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Bac_luciferase,Condensation,Methyltransf_24,PP-binding,TauD
CMS2_k127_3589193_2	667014.Thein_1436	8.911e-06	52.0	COG1943@1|root,COG1943@2|Bacteria,2GI5R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
CMS2_k127_3589193_0	1047013.AQSP01000076_gene1473	1.323e-57	201.0	COG2020@1|root,COG2020@2|Bacteria,2NR07@2323|unclassified Bacteria	2|Bacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CMS2_k127_3592881_4	1047013.AQSP01000144_gene806	1.572e-23	108.0	COG1032@1|root,COG1032@2|Bacteria,2NQIM@2323|unclassified Bacteria	2|Bacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_3592881_1	247490.KSU1_D0299	4.061e-115	376.0	COG0500@1|root,COG2226@2|Bacteria,2J1BW@203682|Planctomycetes	203682|Planctomycetes	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS2_k127_3592881_2	247490.KSU1_D0298	9.403e-87	293.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.197,2.1.1.222,2.1.1.64	ko:K00568,ko:K02169	ko00130,ko00780,ko01100,ko01110,map00130,map00780,map01100,map01110	M00117,M00572	R04988,R05614,R08769,R08781,R09543	RC00003,RC00392,RC00460,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31,TPR_8
CMS2_k127_3592881_0	247490.KSU1_D0297	9.887e-226	710.0	COG0438@1|root,COG0438@2|Bacteria,2J10U@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_3592881_3	395961.Cyan7425_3879	1.194e-45	172.0	COG5360@1|root,COG5360@2|Bacteria,1G4V0@1117|Cyanobacteria	1117|Cyanobacteria	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III,Hepar_II_III_N
CMS2_k127_3597263_0	1009370.ALO_00935	5.998e-278	904.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_3608378_6	1122971.BAME01000022_gene2354	0.0002932	45.0	COG5464@1|root,COG5464@2|Bacteria,4P3AF@976|Bacteroidetes,2FTGU@200643|Bacteroidia	976|Bacteroidetes	S	transposase or invertase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3608378_2	1041826.FCOL_12375	1.235e-78	269.0	COG5464@1|root,COG5464@2|Bacteria,4NJT2@976|Bacteroidetes,1IDMC@117743|Flavobacteriia,2NYR8@237|Flavobacterium	976|Bacteroidetes	S	to proteins from other organisms	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_3608378_0	521045.Kole_1972	0.0	1245.0	COG0553@1|root,COG3886@1|root,COG0553@2|Bacteria,COG3886@2|Bacteria,2GDGR@200918|Thermotogae	200918|Thermotogae	L	helicase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3883,Helicase_C,PLDc_2,SNF2_N
CMS2_k127_3608378_1	521045.Kole_1971	2.156e-245	792.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2GDZE@200918|Thermotogae	200918|Thermotogae	L	Eco57I restriction-modification methylase	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Eco57I,TaqI_C
CMS2_k127_3608378_4	269799.Gmet_0082	2.519e-27	127.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	pkn2	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Guanylate_cyc,Pkinase,SatD
CMS2_k127_3608378_3	572479.Hprae_1159	8.838e-41	169.0	COG1637@1|root,COG1637@2|Bacteria,1TRIZ@1239|Firmicutes,24GF2@186801|Clostridia	186801|Clostridia	L	Domain of unknown function (DUF4268)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4268
CMS2_k127_3608378_5	1121094.KB894643_gene1934	1.838e-17	85.0	COG5464@1|root,COG5464@2|Bacteria,4NJT2@976|Bacteroidetes,2FQ31@200643|Bacteroidia,4AW7W@815|Bacteroidaceae	976|Bacteroidetes	S	PD-(D/E)XK nuclease family transposase	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_3609704_0	497965.Cyan7822_5495	2.86e-23	115.0	COG2319@1|root,COG5635@1|root,COG2319@2|Bacteria,COG5635@2|Bacteria,1FZVW@1117|Cyanobacteria,3KH8A@43988|Cyanothece	1117|Cyanobacteria	L	WD-40 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,Pentapeptide,WD40
CMS2_k127_361992_9	218851.Aquca_039_00114.1	1.462e-82	305.0	COG4886@1|root,2QQYD@2759|Eukaryota,37P0C@33090|Viridiplantae,3G8IW@35493|Streptophyta	35493|Streptophyta	T	LRR receptor-like serine threonine-protein kinase	-	-	2.7.11.1	ko:K04730	ko04010,ko04064,ko04620,ko04624,ko04722,ko05133,ko05140,ko05142,ko05145,ko05152,ko05162,ko05169,map04010,map04064,map04620,map04624,map04722,map05133,map05140,map05142,map05145,map05152,map05162,map05169	M00686	-	-	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	LRRNT_2,LRR_1,LRR_8,Pkinase
CMS2_k127_361992_25	903818.KI912268_gene2809	0.0002277	51.0	COG4733@1|root,COG4932@1|root,COG4733@2|Bacteria,COG4932@2|Bacteria,3Y930@57723|Acidobacteria	57723|Acidobacteria	M	Flagellar hook protein flgE	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF4082
CMS2_k127_361992_24	1047013.AQSP01000084_gene765	2.943e-05	54.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
CMS2_k127_361992_16	944480.ATUV01000002_gene132	1.235e-18	94.0	COG0558@1|root,COG1213@1|root,COG0558@2|Bacteria,COG1213@2|Bacteria,1NN43@1224|Proteobacteria,432HN@68525|delta/epsilon subdivisions,2WYCV@28221|Deltaproteobacteria,2M7MC@213113|Desulfurellales	28221|Deltaproteobacteria	IM	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
CMS2_k127_361992_17	269800.Tfu_2520	2.378e-18	95.0	COG0500@1|root,COG2226@2|Bacteria,2IERY@201174|Actinobacteria,4ENCM@85012|Streptosporangiales	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_361992_15	237368.SCABRO_03088	5.516e-22	107.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS2_k127_361992_19	13249.RPRC009893-PA	3.134e-10	74.0	KOG0583@1|root,KOG0583@2759|Eukaryota,39WJ2@33154|Opisthokonta,3BIGD@33208|Metazoa,3D4P1@33213|Bilateria,41YHV@6656|Arthropoda,3SH1V@50557|Insecta,3EC7T@33342|Paraneoptera	33208|Metazoa	T	Serine/Threonine protein kinases, catalytic domain	-	-	2.7.11.1	ko:K08811	-	-	-	-	ko00000,ko01000,ko01001,ko03036	-	-	-	Pkinase
CMS2_k127_361992_21	246199.CUS_6385	1.562e-07	57.0	2DHAX@1|root,32U8Z@2|Bacteria,1VV1S@1239|Firmicutes,250GD@186801|Clostridia,3WM8Y@541000|Ruminococcaceae	186801|Clostridia	S	Zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	DZR
CMS2_k127_361992_20	1122176.KB903535_gene1970	2.497e-09	71.0	COG5276@1|root,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes	976|Bacteroidetes	E	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD,MAM,TSP_3,fn3
CMS2_k127_361992_7	439235.Dalk_0237	1.991e-106	375.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_361992_11	1499967.BAYZ01000125_gene2598	9.291e-46	183.0	COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,Sulfatase
CMS2_k127_361992_10	1047013.AQSP01000121_gene2689	1.009e-47	191.0	COG2755@1|root,COG2755@2|Bacteria,2NRYN@2323|unclassified Bacteria	2|Bacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_20,DUF1796,Lipase_GDSL_2
CMS2_k127_361992_1	1499967.BAYZ01000009_gene5391	3.958e-308	963.0	COG2766@1|root,COG2766@2|Bacteria	2|Bacteria	T	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_PrkA,PrkA
CMS2_k127_361992_2	1499967.BAYZ01000009_gene5392	3.29e-254	794.0	COG2719@1|root,COG2719@2|Bacteria	2|Bacteria	S	cellular response to DNA damage stimulus	spoVR	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
CMS2_k127_361992_4	1499967.BAYZ01000009_gene5393	2.325e-195	619.0	COG2718@1|root,COG2718@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF444)	yhbH	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444,Haem_oxygenas_2
CMS2_k127_361992_0	1499967.BAYZ01000009_gene5394	0.0	1192.0	COG2766@1|root,COG2766@2|Bacteria	2|Bacteria	T	protein kinase activity	prkA	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
CMS2_k127_361992_13	1047013.AQSP01000079_gene2043	1.006e-35	147.0	COG0810@1|root,COG0810@2|Bacteria,2NQ1D@2323|unclassified Bacteria	2|Bacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,TonB_C
CMS2_k127_361992_23	1242864.D187_003091	4.554e-06	52.0	COG1672@1|root,COG1672@2|Bacteria,1NTWM@1224|Proteobacteria,4381T@68525|delta/epsilon subdivisions,2X9V3@28221|Deltaproteobacteria,2YVBC@29|Myxococcales	28221|Deltaproteobacteria	O	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35,TIR_2,Trypsin_2
CMS2_k127_361992_8	203124.Tery_2383	2.986e-85	321.0	COG0210@1|root,COG0457@1|root,COG0210@2|Bacteria,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1H968@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,TPR_1,TPR_11,TPR_2,TPR_8
CMS2_k127_361992_3	471854.Dfer_1607	6.483e-200	674.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47TR0@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Response_reg,Y_Y_Y
CMS2_k127_361992_22	177437.HRM2_44590	2.655e-07	59.0	COG2963@1|root,COG2963@2|Bacteria,1NGD6@1224|Proteobacteria,42X6G@68525|delta/epsilon subdivisions,2WT2N@28221|Deltaproteobacteria,2MMEI@213118|Desulfobacterales	28221|Deltaproteobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
CMS2_k127_361992_12	177437.HRM2_39530	4.445e-43	160.0	COG3436@1|root,COG3436@2|Bacteria,1MYCD@1224|Proteobacteria,42TEE@68525|delta/epsilon subdivisions,2WPUG@28221|Deltaproteobacteria,2MPR3@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
CMS2_k127_361992_5	1304885.AUEY01000056_gene1443	4.061e-157	512.0	COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,43CRI@68525|delta/epsilon subdivisions,2X7Z7@28221|Deltaproteobacteria,2MIWI@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
CMS2_k127_361992_14	313606.M23134_04871	2.836e-23	107.0	COG1945@1|root,COG1945@2|Bacteria,4NKCB@976|Bacteroidetes	976|Bacteroidetes	S	arginine decarboxylase	-	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
CMS2_k127_361992_18	1313421.JHBV01000049_gene92	7.958e-15	78.0	COG5464@1|root,COG5464@2|Bacteria,4NJT2@976|Bacteroidetes,1IRNY@117747|Sphingobacteriia	976|Bacteroidetes	S	transposase or invertase	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_3626238_0	439235.Dalk_0237	1.392e-102	351.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_3637009_4	471854.Dfer_1607	2.035e-210	704.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47TR0@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Response_reg,Y_Y_Y
CMS2_k127_3637009_51	269797.Mbar_A2759	6.677e-50	191.0	COG0265@1|root,arCOG02833@2157|Archaea	2157|Archaea	O	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Trypsin_2
CMS2_k127_3637009_74	1218108.KB908304_gene16	1.19e-29	127.0	COG2020@1|root,COG2020@2|Bacteria,4NJCI@976|Bacteroidetes,1I1CA@117743|Flavobacteriia	976|Bacteroidetes	O	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CMS2_k127_3637009_66	717231.Flexsi_1331	1.592e-37	156.0	COG1649@1|root,COG1649@2|Bacteria,2GEW5@200930|Deferribacteres	200930|Deferribacteres	S	Hypothetical glycosyl hydrolase family 13	-	-	-	ko:K11931	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000	-	-	-	GHL13
CMS2_k127_3637009_54	1047013.AQSP01000111_gene1686	1.035e-47	181.0	COG0095@1|root,COG0095@2|Bacteria,2NPP1@2323|unclassified Bacteria	2|Bacteria	H	Biotin/lipoate A/B protein ligase family	lipM	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
CMS2_k127_3637009_87	1499967.BAYZ01000158_gene436	1.102e-23	106.0	COG1664@1|root,COG1664@2|Bacteria,2NQ1N@2323|unclassified Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
CMS2_k127_3637009_65	1382359.JIAL01000001_gene1723	7.268e-38	146.0	COG0203@1|root,COG0203@2|Bacteria,3Y4JF@57723|Acidobacteria,2JJ8Q@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
CMS2_k127_3637009_23	234267.Acid_5090	8.901e-89	304.0	COG0202@1|root,COG0202@2|Bacteria,3Y3HK@57723|Acidobacteria	57723|Acidobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
CMS2_k127_3637009_32	555079.Toce_0146	1.14e-74	256.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,42ENH@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
CMS2_k127_3637009_55	1121468.AUBR01000044_gene1835	2.093e-47	173.0	COG0100@1|root,COG0100@2|Bacteria,1V3IK@1239|Firmicutes,24HIK@186801|Clostridia,42G9M@68295|Thermoanaerobacterales	186801|Clostridia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
CMS2_k127_3637009_63	1047013.AQSP01000074_gene1890	1.509e-39	150.0	COG0099@1|root,COG0099@2|Bacteria,2NPKH@2323|unclassified Bacteria	2|Bacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
CMS2_k127_3637009_109	768670.Calni_1484	9.899e-13	68.0	COG0257@1|root,COG0257@2|Bacteria,2GG6B@200930|Deferribacteres	200930|Deferribacteres	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
CMS2_k127_3637009_85	572547.Amico_0651	6.511e-25	105.0	COG0361@1|root,COG0361@2|Bacteria,3TBCB@508458|Synergistetes	508458|Synergistetes	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
CMS2_k127_3637009_24	1120973.AQXL01000112_gene1094	5.781e-87	294.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,4H9S9@91061|Bacilli,277XD@186823|Alicyclobacillaceae	91061|Bacilli	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
CMS2_k127_3637009_43	944479.JQLX01000017_gene291	4.878e-60	214.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria,2M6C5@213113|Desulfurellales	28221|Deltaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
CMS2_k127_3637009_6	1047013.AQSP01000074_gene1894	2.277e-199	630.0	COG0201@1|root,COG0201@2|Bacteria,2NNVK@2323|unclassified Bacteria	2|Bacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
CMS2_k127_3637009_60	1047013.AQSP01000074_gene1895	2.819e-42	159.0	COG0200@1|root,COG0200@2|Bacteria,2NPNV@2323|unclassified Bacteria	2|Bacteria	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
CMS2_k127_3637009_105	1047013.AQSP01000074_gene1896	6.255e-14	74.0	COG1841@1|root,COG1841@2|Bacteria,2NQ1P@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein L30	rpmD	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
CMS2_k127_3637009_49	309803.CTN_1010	4.757e-52	188.0	COG0098@1|root,COG0098@2|Bacteria,2GD0Y@200918|Thermotogae	200918|Thermotogae	J	Belongs to the universal ribosomal protein uS5 family	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
CMS2_k127_3637009_76	351627.Csac_2271	4.576e-28	117.0	COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,24JCS@186801|Clostridia,42GIE@68295|Thermoanaerobacterales	186801|Clostridia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
CMS2_k127_3637009_61	639282.DEFDS_1757	1.103e-40	156.0	COG0097@1|root,COG0097@2|Bacteria,2GFGZ@200930|Deferribacteres	200930|Deferribacteres	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
CMS2_k127_3637009_58	1121920.AUAU01000010_gene89	1.389e-43	162.0	COG0096@1|root,COG0096@2|Bacteria,3Y4IE@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
CMS2_k127_3637009_94	1205910.B005_2718	5.273e-21	93.0	COG0199@1|root,COG0199@2|Bacteria,2IQ8R@201174|Actinobacteria,4EKES@85012|Streptosporangiales	201174|Actinobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
CMS2_k127_3637009_38	278963.ATWD01000001_gene1828	4.748e-69	238.0	COG0094@1|root,COG0094@2|Bacteria,3Y3PS@57723|Acidobacteria,2JHV4@204432|Acidobacteriia	204432|Acidobacteriia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
CMS2_k127_3637009_88	639282.DEFDS_1761	1.372e-23	104.0	COG0198@1|root,COG0198@2|Bacteria,2GFUM@200930|Deferribacteres	200930|Deferribacteres	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
CMS2_k127_3637009_52	1047013.AQSP01000074_gene1903	6.727e-49	177.0	COG0093@1|root,COG0093@2|Bacteria,2NPCS@2323|unclassified Bacteria	2|Bacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
CMS2_k127_3637009_96	643648.Slip_2228	1.378e-19	93.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,42K48@68298|Syntrophomonadaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
CMS2_k127_3637009_119	583355.Caka_1681	1.973e-07	57.0	COG0255@1|root,COG0255@2|Bacteria,46WKJ@74201|Verrucomicrobia,3K8FF@414999|Opitutae	414999|Opitutae	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
CMS2_k127_3637009_48	1047013.AQSP01000074_gene1906	1.579e-57	203.0	COG0197@1|root,COG0197@2|Bacteria,2NPC6@2323|unclassified Bacteria	2|Bacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
CMS2_k127_3637009_36	891968.Anamo_0480	4.261e-71	248.0	COG0092@1|root,COG0092@2|Bacteria,3TABJ@508458|Synergistetes	508458|Synergistetes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
CMS2_k127_3637009_73	1047013.AQSP01000074_gene1908	3.238e-32	128.0	COG0091@1|root,COG0091@2|Bacteria,2NPNW@2323|unclassified Bacteria	2|Bacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
CMS2_k127_3637009_72	879212.DespoDRAFT_02466	3.142e-32	127.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,42THY@68525|delta/epsilon subdivisions,2WQ0F@28221|Deltaproteobacteria,2MKPD@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
CMS2_k127_3637009_15	1047013.AQSP01000074_gene1910	1.081e-118	387.0	COG0090@1|root,COG0090@2|Bacteria,2NNR3@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
CMS2_k127_3637009_95	1047013.AQSP01000074_gene1911	1.428e-20	95.0	COG0089@1|root,COG0089@2|Bacteria,2NPWC@2323|unclassified Bacteria	2|Bacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
CMS2_k127_3637009_41	1047013.AQSP01000074_gene1912	1.953e-62	220.0	COG0088@1|root,COG0088@2|Bacteria,2NPF3@2323|unclassified Bacteria	2|Bacteria	J	Forms part of the polypeptide exit tunnel	rplD	GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030312,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141	-	ko:K02926,ko:K16193	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
CMS2_k127_3637009_37	1047013.AQSP01000074_gene1913	3.095e-69	240.0	COG0087@1|root,COG0087@2|Bacteria,2NPAI@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
CMS2_k127_3637009_64	1047013.AQSP01000074_gene1914	1.78e-38	146.0	COG0051@1|root,COG0051@2|Bacteria,2NPJY@2323|unclassified Bacteria	2|Bacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
CMS2_k127_3637009_5	1047013.AQSP01000086_gene2010	4.251e-205	643.0	COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria	2|Bacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
CMS2_k127_3637009_1	555079.Toce_0116	2.487e-261	822.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,42EYD@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS2_k127_3637009_46	580331.Thit_1979	4.952e-59	208.0	COG0049@1|root,COG0049@2|Bacteria,1V1GG@1239|Firmicutes,24FQN@186801|Clostridia,42G2K@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
CMS2_k127_3637009_47	665571.STHERM_c04920	2.439e-58	204.0	COG0048@1|root,COG0048@2|Bacteria,2J7NE@203691|Spirochaetes	203691|Spirochaetes	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
CMS2_k127_3637009_42	573370.DMR_03420	3.791e-60	211.0	2AU0F@1|root,31JKB@2|Bacteria,1RGGF@1224|Proteobacteria,42S33@68525|delta/epsilon subdivisions,2WNKG@28221|Deltaproteobacteria,2MC3F@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3637009_99	1392491.JIAE01000001_gene2529	4.178e-17	81.0	2DPII@1|root,3327T@2|Bacteria,1VHT9@1239|Firmicutes,24RHP@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3637009_70	1120966.AUBU01000030_gene2984	1.072e-34	134.0	29YB4@1|root,30K5C@2|Bacteria,4PB90@976|Bacteroidetes,47VG6@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3637009_100	411483.FAEPRAA2165_02967	3.375e-16	84.0	2B9ZZ@1|root,323DM@2|Bacteria,1V6N4@1239|Firmicutes,24K1H@186801|Clostridia,3WJW5@541000|Ruminococcaceae	186801|Clostridia	S	non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3637009_107	72658.Bostr.14018s0001.1.p	5.237e-13	68.0	2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GMF3@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3637009_97	123214.PERMA_1937	5.184e-19	88.0	2DQZN@1|root,339JB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3637009_56	1047013.AQSP01000121_gene2703	4.511e-47	170.0	2DMHR@1|root,32RMI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3637009_112	1191299.AJYX01000041_gene3747	7.458e-10	59.0	2DMHR@1|root,32RMI@2|Bacteria,1QK1W@1224|Proteobacteria,1TI4F@1236|Gammaproteobacteria,1XYCQ@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3637009_106	1173021.ALWA01000027_gene2631	3.433e-13	69.0	2EK6X@1|root,33DXA@2|Bacteria,1GFHH@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3637009_68	498761.HM1_3148	5.546e-35	136.0	2DN97@1|root,32W7A@2|Bacteria,1VANB@1239|Firmicutes,24Q9J@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3637009_124	253839.SSNG_01640	4.167e-05	49.0	2DSQW@1|root,33H3S@2|Bacteria,2GTIV@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3637009_102	1123371.ATXH01000052_gene627	2.822e-14	74.0	2DTS4@1|root,33MFD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3637009_123	1195236.CTER_1713	1.046e-05	53.0	COG1813@1|root,COG1813@2|Bacteria,1VEVE@1239|Firmicutes,25F53@186801|Clostridia	186801|Clostridia	K	PFAM Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS2_k127_3637009_71	247490.KSU1_D0599	1.568e-33	145.0	COG4191@1|root,COG4191@2|Bacteria,2IYZD@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS2_k127_3637009_104	1047013.AQSP01000083_gene1202	4.459e-14	86.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	yacD	-	5.2.1.8	ko:K03770,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,SurA_N_3
CMS2_k127_3637009_13	945713.IALB_2955	7.01e-137	445.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
CMS2_k127_3637009_20	1047013.AQSP01000033_gene1395	1.147e-95	321.0	COG0320@1|root,COG0320@2|Bacteria,2NNPI@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
CMS2_k127_3637009_45	933262.AXAM01000002_gene504	2.377e-59	220.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria,2MI6A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
CMS2_k127_3637009_30	1047013.AQSP01000140_gene2511	1.953e-78	297.0	COG2202@1|root,COG2203@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3920@2|Bacteria,2NPS5@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	pdtaS	-	2.7.13.3	ko:K00936,ko:K02030	-	M00236,M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02000,ko02022	3.A.1.3	-	-	HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,PAS_3,PAS_9
CMS2_k127_3637009_103	402881.Plav_1084	3.465e-14	87.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9
CMS2_k127_3637009_22	118168.MC7420_3521	3.541e-95	321.0	COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales	1117|Cyanobacteria	KLT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_35,GAF,HATPase_c,HisKA,Pkinase
CMS2_k127_3637009_21	234267.Acid_4295	2.609e-95	325.0	COG2208@1|root,COG4753@1|root,COG2208@2|Bacteria,COG4753@2|Bacteria,3Y6AE@57723|Acidobacteria	57723|Acidobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
CMS2_k127_3637009_53	1410653.JHVC01000012_gene2383	1.109e-48	188.0	COG1680@1|root,COG1680@2|Bacteria,1U828@1239|Firmicutes,249GA@186801|Clostridia,36FAS@31979|Clostridiaceae	186801|Clostridia	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_3637009_33	1047013.AQSP01000085_gene1995	3.38e-73	258.0	COG0673@1|root,COG0673@2|Bacteria,2NNUQ@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	gnnA	-	-	ko:K09949	-	-	-	-	ko00000	-	-	iAF987.Gmet_2352	GFO_IDH_MocA
CMS2_k127_3637009_34	1047013.AQSP01000085_gene1997	1.251e-71	252.0	COG1043@1|root,COG1043@2|Bacteria,2NP5V@2323|unclassified Bacteria	2|Bacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008780,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iIT341.HP1375,iPC815.YPO1056	Acetyltransf_11,Hexapep
CMS2_k127_3637009_59	1123236.KB899381_gene3038	2.244e-42	160.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,466WK@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
CMS2_k127_3637009_110	795359.TOPB45_0412	1.638e-11	71.0	COG2825@1|root,COG2825@2|Bacteria,2GHCV@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
CMS2_k127_3637009_9	1047013.AQSP01000085_gene2000	3.005e-169	558.0	COG4775@1|root,COG4775@2|Bacteria,2NNNW@2323|unclassified Bacteria	2|Bacteria	M	Surface antigen	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
CMS2_k127_3637009_40	290317.Cpha266_1717	3.545e-65	230.0	COG1462@1|root,COG1462@2|Bacteria	2|Bacteria	M	curli production assembly transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
CMS2_k127_3637009_25	1047013.AQSP01000139_gene2345	1.168e-86	296.0	COG0731@1|root,COG0731@2|Bacteria,2NPIJ@2323|unclassified Bacteria	2|Bacteria	C	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
CMS2_k127_3637009_81	1121422.AUMW01000024_gene242	1.438e-25	107.0	COG0694@1|root,COG0694@2|Bacteria,1VAAU@1239|Firmicutes,24R29@186801|Clostridia,26375@186807|Peptococcaceae	186801|Clostridia	O	PFAM nitrogen-fixing NifU domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NifU
CMS2_k127_3637009_28	1041930.Mtc_0249	7.958e-81	273.0	COG0450@1|root,arCOG00312@2157|Archaea,2XYCY@28890|Euryarchaeota	28890|Euryarchaeota	O	AhpC/TSA family	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
CMS2_k127_3637009_69	269799.Gmet_0785	6.02e-35	150.0	COG1538@1|root,COG1538@2|Bacteria,1QWWG@1224|Proteobacteria,42PD6@68525|delta/epsilon subdivisions,2WK6G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_3637009_117	243231.GSU0813	2.036e-08	63.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,42U8G@68525|delta/epsilon subdivisions,2WQPS@28221|Deltaproteobacteria,43USX@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	MlaC protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
CMS2_k127_3637009_77	485913.Krac_5383	7.224e-28	119.0	COG0346@1|root,COG0622@1|root,COG0346@2|Bacteria,COG0622@2|Bacteria,2G8MU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS2_k127_3637009_83	485913.Krac_5383	2.672e-25	111.0	COG0346@1|root,COG0622@1|root,COG0346@2|Bacteria,COG0622@2|Bacteria,2G8MU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS2_k127_3637009_90	555088.DealDRAFT_1718	6.287e-23	98.0	COG2768@1|root,COG2768@2|Bacteria,1VET2@1239|Firmicutes,24QUH@186801|Clostridia,42K86@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
CMS2_k127_3637009_108	272844.PAB1368	7.748e-13	77.0	COG2517@1|root,arCOG04359@2157|Archaea,2XV20@28890|Euryarchaeota,242V2@183968|Thermococci	183968|Thermococci	S	Putative tRNA binding domain	-	-	-	ko:K07135	-	-	-	-	ko00000	-	-	-	tRNA_bind
CMS2_k127_3637009_0	1047013.AQSP01000092_gene315	0.0	1199.0	COG3250@1|root,COG3250@2|Bacteria,2NQEM@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolases family 2, TIM barrel domain	lacZ	GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005575,GO:0005975,GO:0005984,GO:0005988,GO:0005990,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009341,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0032991,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0071704,GO:1901575,GO:1902494	3.2.1.23,3.2.1.31	ko:K01190,ko:K01195	ko00040,ko00052,ko00511,ko00531,ko00600,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00052,map00511,map00531,map00600,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01105,R01478,R01678,R03355,R04783,R04979,R06114,R07818,R08127,R08260,R10830	RC00049,RC00055,RC00171,RC00452,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
CMS2_k127_3637009_27	103690.17130206	7.448e-82	293.0	COG5316@1|root,COG5316@2|Bacteria,1G2S6@1117|Cyanobacteria,1HRVY@1161|Nostocales	1117|Cyanobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
CMS2_k127_3637009_93	331678.Cphamn1_1502	4.196e-21	99.0	COG2318@1|root,COG2318@2|Bacteria,1FF6X@1090|Chlorobi	1090|Chlorobi	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS2_k127_3637009_26	1047013.AQSP01000105_gene1436	2.958e-84	289.0	COG2421@1|root,COG2421@2|Bacteria,2NR72@2323|unclassified Bacteria	2|Bacteria	C	Acetamidase/Formamidase family	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
CMS2_k127_3637009_7	1047013.AQSP01000123_gene1547	1.573e-193	653.0	COG4251@1|root,COG4251@2|Bacteria,2NS53@2323|unclassified Bacteria	2|Bacteria	T	GAF domain	letS	-	2.7.13.3	ko:K07678,ko:K07716	ko02020,ko02025,ko02026,ko04112,ko05111,map02020,map02025,map02026,map04112,map05111	M00475,M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE3,DUF2222,HAMP,HATPase_c,HisKA,Hpt,PAS_4,Response_reg
CMS2_k127_3637009_84	335543.Sfum_4006	4.269e-25	117.0	COG4932@1|root,COG4932@2|Bacteria,1P8KK@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3637009_3	1237149.C900_05289	4.759e-216	702.0	2DBDU@1|root,2Z8P5@2|Bacteria,4NFFA@976|Bacteroidetes,47TRU@768503|Cytophagia	976|Bacteroidetes	S	Lantibiotic dehydratase, C terminus	-	-	-	-	-	-	-	-	-	-	-	-	Lant_dehydr_N
CMS2_k127_3637009_18	1237149.C900_05290	6.669e-97	327.0	COG0778@1|root,COG0778@2|Bacteria,4PM4U@976|Bacteroidetes	976|Bacteroidetes	C	Lantibiotic biosynthesis dehydratase C-term	-	-	-	-	-	-	-	-	-	-	-	-	Lant_dehydr_C
CMS2_k127_3637009_16	868864.Dester_0654	4.68e-114	385.0	COG1921@1|root,COG1921@2|Bacteria,2G3ND@200783|Aquificae	200783|Aquificae	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
CMS2_k127_3637009_62	55529.EKX38048	5.03e-40	157.0	2C8MV@1|root,2S34S@2759|Eukaryota	2759|Eukaryota	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
CMS2_k127_3637009_44	1047013.AQSP01000036_gene1386	4.899e-60	224.0	COG0037@1|root,COG0037@2|Bacteria,2NPAZ@2323|unclassified Bacteria	2|Bacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
CMS2_k127_3637009_35	1191523.MROS_1339	2.677e-71	249.0	COG3634@1|root,COG3634@2|Bacteria	2|Bacteria	C	alkyl hydroperoxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
CMS2_k127_3637009_122	1408418.JNJH01000020_gene967	2.807e-06	51.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,2JV8U@204441|Rhodospirillales	204441|Rhodospirillales	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
CMS2_k127_3637009_17	1047013.AQSP01000101_gene613	8.271e-104	357.0	COG2812@1|root,COG2812@2|Bacteria,2NNK7@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7,6.1.1.17	ko:K01885,ko:K02341,ko:K02343	ko00230,ko00240,ko00860,ko00970,ko01100,ko01110,ko01120,ko03030,ko03430,ko03440,map00230,map00240,map00860,map00970,map01100,map01110,map01120,map03030,map03430,map03440	M00121,M00260,M00359,M00360	R00375,R00376,R00377,R00378,R05578	RC00055,RC00523,RC02795	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
CMS2_k127_3637009_78	997346.HMPREF9374_2654	6.107e-27	113.0	COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,4HKH3@91061|Bacilli,27C8N@186824|Thermoactinomycetaceae	91061|Bacilli	S	YbaB/EbfC DNA-binding family	yaaK	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
CMS2_k127_3637009_39	1047013.AQSP01000101_gene611	6.987e-69	239.0	COG0353@1|root,COG0353@2|Bacteria,2NP5N@2323|unclassified Bacteria	2|Bacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
CMS2_k127_3637009_86	1209989.TepiRe1_2371	2.7e-24	109.0	COG1014@1|root,COG1014@2|Bacteria,1TRFJ@1239|Firmicutes,24A29@186801|Clostridia,42GE2@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit	porC	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
CMS2_k127_3637009_79	1499967.BAYZ01000016_gene6492	1.732e-26	111.0	COG1144@1|root,COG1144@2|Bacteria,2NRX4@2323|unclassified Bacteria	2|Bacteria	C	Oxidoreductase	porD	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00171,ko:K00172,ko:K19072	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_10,Fer4_21,POR
CMS2_k127_3637009_14	1304880.JAGB01000004_gene1407	1.286e-126	417.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia	186801|Clostridia	C	pyruvate flavodoxin ferredoxin oxidoreductase	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
CMS2_k127_3637009_19	574087.Acear_0037	7.788e-96	323.0	COG1013@1|root,COG1013@2|Bacteria,1TPF0@1239|Firmicutes,24BE5@186801|Clostridia,3WAIQ@53433|Halanaerobiales	186801|Clostridia	C	PFAM Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	porB	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
CMS2_k127_3637009_121	670487.Ocepr_1645	1.455e-06	56.0	COG2018@1|root,COG2018@2|Bacteria,1WJYW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Roadblock LC7	-	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
CMS2_k127_3637009_29	204669.Acid345_0708	7.575e-80	270.0	COG1100@1|root,COG1100@2|Bacteria,3Y7CQ@57723|Acidobacteria	57723|Acidobacteria	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
CMS2_k127_3637009_11	1047013.AQSP01000140_gene2453	1.68e-149	485.0	COG0065@1|root,COG0065@2|Bacteria,2NNXE@2323|unclassified Bacteria	2|Bacteria	E	Aconitase family (aconitate hydratase)	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
CMS2_k127_3637009_50	1047013.AQSP01000140_gene2454	7.357e-51	185.0	COG0066@1|root,COG0066@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	leuD	-	4.2.1.33,4.2.1.35,4.2.1.36	ko:K01704,ko:K01705	ko00290,ko00300,ko00660,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map01100,map01110,map01120,map01130,map01210,map01230	M00030,M00432,M00433,M00535	R03896,R03898,R03968,R04001,R04371,R10170	RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
CMS2_k127_3637009_31	373903.Hore_13850	7.392e-75	258.0	COG1573@1|root,COG1573@2|Bacteria,1V1SU@1239|Firmicutes,24E7B@186801|Clostridia	186801|Clostridia	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
CMS2_k127_3637009_98	1168289.AJKI01000002_gene2514	3.764e-18	85.0	COG1141@1|root,COG1141@2|Bacteria,4P7D9@976|Bacteroidetes,2FZ83@200643|Bacteroidia	976|Bacteroidetes	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13
CMS2_k127_3637009_75	472759.Nhal_1483	1.712e-29	131.0	COG3675@1|root,COG3675@2|Bacteria,1ND8U@1224|Proteobacteria,1SCPC@1236|Gammaproteobacteria,1X1HS@135613|Chromatiales	135613|Chromatiales	I	PFAM lipase class 3	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_3
CMS2_k127_3637009_12	880073.Calab_0388	1.393e-144	469.0	COG2195@1|root,COG2195@2|Bacteria,2NPYT@2323|unclassified Bacteria	2|Bacteria	E	Cleaves the N-terminal amino acid of tripeptides	pepT	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0034701,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045148,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M42
CMS2_k127_3637009_8	1121413.JMKT01000008_gene1523	3.075e-193	619.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,42MSA@68525|delta/epsilon subdivisions,2WIS1@28221|Deltaproteobacteria,2M92C@213115|Desulfovibrionales	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568,ko:K12137	-	-	-	-	ko00000,ko01000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
CMS2_k127_3637009_125	1121439.dsat_0525	5.667e-05	50.0	2BPZK@1|root,32ITM@2|Bacteria,1PBVB@1224|Proteobacteria,4370G@68525|delta/epsilon subdivisions,2X1R9@28221|Deltaproteobacteria,2MFI3@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3637009_2	1121930.AQXG01000002_gene2029	2.033e-219	691.0	COG0651@1|root,COG0651@2|Bacteria	2|Bacteria	CP	ATP synthesis coupled electron transport	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
CMS2_k127_3637009_10	1121930.AQXG01000002_gene2028	9.162e-167	539.0	COG0651@1|root,COG0651@2|Bacteria,4NGBC@976|Bacteroidetes,1IPUK@117747|Sphingobacteriia	976|Bacteroidetes	CP	Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali	mrpD	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
CMS2_k127_3637009_67	1121930.AQXG01000002_gene2027	3.059e-37	144.0	COG1006@1|root,COG1006@2|Bacteria,4P7CV@976|Bacteroidetes	976|Bacteroidetes	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q2
CMS2_k127_3637009_57	1121930.AQXG01000002_gene2026	2.525e-45	169.0	COG2111@1|root,COG2111@2|Bacteria,4P6YI@976|Bacteroidetes	976|Bacteroidetes	P	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	-	-	-	-	-	-	-	-	-	MnhB
CMS2_k127_3637009_80	1121930.AQXG01000002_gene2025	1.897e-26	111.0	COG2111@1|root,COG2111@2|Bacteria	2|Bacteria	P	Na H antiporter	mnhB	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB
CMS2_k127_3637009_92	1121930.AQXG01000002_gene2024	3.958e-21	95.0	COG1563@1|root,COG1563@2|Bacteria	2|Bacteria	P	Domain of unknown function (DUF4040)	mnhB	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB
CMS2_k127_3637009_89	1121930.AQXG01000002_gene2023	3.688e-23	102.0	COG1320@1|root,COG1320@2|Bacteria,4NWMX@976|Bacteroidetes,1IUP8@117747|Sphingobacteriia	976|Bacteroidetes	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
CMS2_k127_3641059_0	1501230.ET33_18925	0.0	2797.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_3641059_1	1265503.KB905162_gene3593	8.394e-141	474.0	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria,2Q7GY@267889|Colwelliaceae	1236|Gammaproteobacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_3641059_4	1158294.JOMI01000001_gene1512	0.0008313	49.0	COG4319@1|root,COG4319@2|Bacteria,4P5ZB@976|Bacteroidetes,2FYYG@200643|Bacteroidia	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
CMS2_k127_3641059_3	1007104.SUS17_1879	1.198e-08	63.0	COG0454@1|root,COG0456@2|Bacteria,1N4JC@1224|Proteobacteria,2UCY3@28211|Alphaproteobacteria,2K4ZS@204457|Sphingomonadales	204457|Sphingomonadales	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
CMS2_k127_3641059_2	506534.Rhein_2184	3.515e-24	107.0	2E6SE@1|root,331CG@2|Bacteria	2|Bacteria	S	Putative lumazine-binding	-	-	-	-	-	-	-	-	-	-	-	-	Lumazine_bd_2
CMS2_k127_3642900_6	1047013.AQSP01000037_gene1323	1.34e-118	389.0	COG1171@1|root,COG1171@2|Bacteria,2NQCM@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_3642900_23	316274.Haur_3191	4.95e-18	100.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Cadherin_3,DUF4347,He_PIG,Laminin_G_2,Laminin_G_3,PKD,Pentaxin
CMS2_k127_3642900_8	439235.Dalk_0237	3.111e-98	357.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_3642900_10	1487953.JMKF01000006_gene5656	4.207e-91	306.0	COG1028@1|root,COG1028@2|Bacteria,1G48H@1117|Cyanobacteria	1117|Cyanobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS2_k127_3642900_7	411477.PARMER_03605	5.367e-108	386.0	COG0553@1|root,COG0553@2|Bacteria,4NH3B@976|Bacteroidetes,2FMG6@200643|Bacteroidia,22ZTW@171551|Porphyromonadaceae	976|Bacteroidetes	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
CMS2_k127_3642900_16	1437824.BN940_15911	6.733e-40	164.0	COG0420@1|root,COG0420@2|Bacteria,1MY4X@1224|Proteobacteria,2VJXS@28216|Betaproteobacteria,3T2EH@506|Alcaligenaceae	28216|Betaproteobacteria	L	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_3642900_34	167539.Pro_0702	7.806e-06	60.0	COG0419@1|root,COG0419@2|Bacteria,1GCSN@1117|Cyanobacteria,1MNI0@1212|Prochloraceae	1117|Cyanobacteria	L	Alternative locus ID	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23
CMS2_k127_3642900_27	388413.ALPR1_12480	1.583e-14	84.0	COG0457@1|root,COG0457@2|Bacteria,4NN6J@976|Bacteroidetes,47PCR@768503|Cytophagia	976|Bacteroidetes	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
CMS2_k127_3642900_14	1047013.AQSP01000131_gene1842	3.278e-56	220.0	COG4783@1|root,COG4783@2|Bacteria	2|Bacteria	L	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	DUF560,Dynamin_N,Peptidase_M48,TPR_19,TPR_8
CMS2_k127_3642900_4	1047013.AQSP01000131_gene1840	1.339e-198	646.0	COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria,2NPK1@2323|unclassified Bacteria	2|Bacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
CMS2_k127_3642900_3	1047013.AQSP01000131_gene1841	1.247e-210	684.0	COG1629@1|root,COG4773@1|root,COG4771@2|Bacteria,COG4773@2|Bacteria,2NP6Z@2323|unclassified Bacteria	2|Bacteria	P	COGs COG1629 Outer membrane receptor protein mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
CMS2_k127_3642900_19	1047013.AQSP01000123_gene1526	9.422e-30	130.0	COG4219@1|root,COG4219@2|Bacteria,2NR11@2323|unclassified Bacteria	2|Bacteria	KT	Peptidase M56	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	DUF4367,TonB_C
CMS2_k127_3642900_1	1499683.CCFF01000013_gene325	8.893e-258	811.0	COG2511@1|root,COG2511@2|Bacteria,1UPG0@1239|Firmicutes,25HFT@186801|Clostridia	186801|Clostridia	J	GatB/GatE catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	GatB_N
CMS2_k127_3642900_2	1047013.AQSP01000142_gene241	5.796e-248	770.0	COG0252@1|root,COG0252@2|Bacteria,2NPMK@2323|unclassified Bacteria	2|Bacteria	EJ	Asparaginase	ansA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
CMS2_k127_3642900_28	933262.AXAM01000145_gene1521	2.491e-14	74.0	COG1672@1|root,COG1672@2|Bacteria,1R4NN@1224|Proteobacteria,42NMV@68525|delta/epsilon subdivisions,2WM2Z@28221|Deltaproteobacteria	2|Bacteria	S	PFAM Archaeal ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_13,AAA_22,AAA_35
CMS2_k127_3642900_0	660470.Theba_0138	7.562e-285	909.0	COG0286@1|root,COG0286@2|Bacteria	2|Bacteria	V	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
CMS2_k127_3642900_26	1869.MB27_36265	5.356e-15	87.0	COG1413@1|root,COG5635@1|root,COG1413@2|Bacteria,COG5635@2|Bacteria,2GNCH@201174|Actinobacteria,4D8ZG@85008|Micromonosporales	201174|Actinobacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4062,HEAT_2,NACHT
CMS2_k127_3642900_30	32042.PstZobell_19943	4.097e-13	76.0	29AX6@1|root,2ZXWB@2|Bacteria,1RE7P@1224|Proteobacteria,1S52J@1236|Gammaproteobacteria,1Z2DX@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3642900_13	293826.Amet_1439	1.897e-63	228.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	-	-	2.3.1.12,2.7.11.1,3.6.4.13	ko:K00627,ko:K03310,ko:K03578,ko:K12132	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko01001	2.A.25	-	-	2-oxoacid_dh,Biotin_lipoyl
CMS2_k127_3642900_15	204669.Acid345_4294	3.338e-53	200.0	COG3481@1|root,COG3481@2|Bacteria,3Y38F@57723|Acidobacteria,2JITD@204432|Acidobacteriia	204432|Acidobacteriia	S	Nucleic acid binding	-	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
CMS2_k127_3642900_17	335543.Sfum_3745	1.276e-34	154.0	COG4775@1|root,COG5616@1|root,COG4775@2|Bacteria,COG5616@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2MQA8@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
CMS2_k127_3642900_9	1047013.AQSP01000121_gene2722	5.795e-93	343.0	COG2911@1|root,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	AsmA_2,DUF748,TamB
CMS2_k127_3642900_11	648996.Theam_1301	1.312e-83	283.0	COG0176@1|root,COG0176@2|Bacteria,2G3ST@200783|Aquificae	200783|Aquificae	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
CMS2_k127_3642900_31	1047013.AQSP01000102_gene981	5.535e-12	76.0	28WP9@1|root,2ZINZ@2|Bacteria	1047013.AQSP01000102_gene981|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3642900_25	1047013.AQSP01000132_gene1736	3.166e-15	89.0	28WP9@1|root,2ZINZ@2|Bacteria	1047013.AQSP01000132_gene1736|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3642900_24	1047013.AQSP01000132_gene1736	2.456e-16	90.0	28WP9@1|root,2ZINZ@2|Bacteria	1047013.AQSP01000132_gene1736|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3642900_35	671143.DAMO_1918	3.679e-05	52.0	COG3678@1|root,COG3678@2|Bacteria,2NRWA@2323|unclassified Bacteria	2|Bacteria	NPTU	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	Metal_resist
CMS2_k127_3642900_20	572547.Amico_0900	1.549e-23	100.0	COG1278@1|root,COG1278@2|Bacteria,3TBIM@508458|Synergistetes	508458|Synergistetes	K	PFAM Cold-shock protein DNA-binding	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CMS2_k127_3642900_12	398767.Glov_3238	5.813e-79	274.0	COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42R3H@68525|delta/epsilon subdivisions,2WMNY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	CobQ CobB MinD ParA nucleotide binding	-	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,HTH_25,ParA
CMS2_k127_3642900_32	316067.Geob_3175	2.112e-11	71.0	COG1426@1|root,COG1426@2|Bacteria,1Q1M4@1224|Proteobacteria,437BV@68525|delta/epsilon subdivisions,2XA05@28221|Deltaproteobacteria,43VFI@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_25
CMS2_k127_3642900_22	1317122.ATO12_15605	2.869e-20	107.0	COG2207@1|root,COG2207@2|Bacteria,4NIJV@976|Bacteroidetes,1HZ3N@117743|Flavobacteriia,2YKN0@290174|Aquimarina	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS2_k127_3642900_5	1210884.HG799463_gene9356	2.6e-144	492.0	COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria,2J2QP@203682|Planctomycetes	203682|Planctomycetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Reg_prop,Y_Y_Y
CMS2_k127_3642900_33	1123511.KB905847_gene3058	6.107e-06	54.0	COG1396@1|root,COG1396@2|Bacteria,1UWN4@1239|Firmicutes,4H62S@909932|Negativicutes	909932|Negativicutes	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS2_k127_3642900_36	349520.PPE_04194	0.000359	49.0	COG1396@1|root,COG1396@2|Bacteria,1UV9W@1239|Firmicutes,4I8J0@91061|Bacilli,2700Q@186822|Paenibacillaceae	91061|Bacilli	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS2_k127_3642900_18	593117.TGAM_2065	4.052e-34	134.0	COG2361@1|root,arCOG05024@2157|Archaea,2Y0GK@28890|Euryarchaeota,244JN@183968|Thermococci	183968|Thermococci	S	Protein of unknown function DUF86	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	DUF86
CMS2_k127_3642900_21	688269.Theth_1687	1.665e-23	102.0	COG1669@1|root,COG1669@2|Bacteria,2GDMT@200918|Thermotogae	200918|Thermotogae	L	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
CMS2_k127_3643003_0	1123053.AUDG01000035_gene746	4.364e-73	254.0	COG3757@1|root,COG3757@2|Bacteria,1N792@1224|Proteobacteria,1SC72@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	lysozyme activity	yegX	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25
CMS2_k127_3643003_1	439235.Dalk_2729	1.397e-58	207.0	COG3809@1|root,COG3809@2|Bacteria,1PZB0@1224|Proteobacteria,433GD@68525|delta/epsilon subdivisions,2WXX5@28221|Deltaproteobacteria,2MP8T@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
CMS2_k127_3644482_6	720555.BATR1942_07205	4.306e-19	91.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	ko:K15664,ko:K15666,ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_3644482_0	398512.JQKC01000009_gene568	0.0	1097.0	COG1020@1|root,COG1020@2|Bacteria,1V12Q@1239|Firmicutes,24ER3@186801|Clostridia,3WNBS@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,PP-binding,QueC,Radical_SAM
CMS2_k127_3644482_4	1121121.KB894288_gene2765	4.462e-118	432.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_3644482_3	509191.AEDB02000067_gene916	1.049e-189	610.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_3644482_2	509191.AEDB02000067_gene917	1.66e-201	672.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WNP0@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3644482_1	1047013.AQSP01000108_gene2058	0.0	1064.0	COG2091@1|root,COG2091@2|Bacteria,2NQGR@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_364459_24	1121957.ATVL01000008_gene3998	2.634e-22	111.0	COG0308@1|root,COG0308@2|Bacteria	2|Bacteria	E	peptide catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_M1,TPR_16,TPR_19,TPR_8
CMS2_k127_364459_36	1120999.JONM01000012_gene2242	0.0001402	54.0	COG0823@1|root,COG0841@1|root,COG1361@1|root,COG1572@1|root,COG1657@1|root,COG2373@1|root,COG4733@1|root,COG0823@2|Bacteria,COG0841@2|Bacteria,COG1361@2|Bacteria,COG1572@2|Bacteria,COG1657@2|Bacteria,COG2373@2|Bacteria,COG4733@2|Bacteria,1QV7E@1224|Proteobacteria,2WHIN@28216|Betaproteobacteria	28216|Betaproteobacteria	M	TIGRFAM Outer membrane protein	-	-	-	ko:K13735,ko:K20276	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_3_2
CMS2_k127_364459_5	398512.JQKC01000027_gene3915	5.558e-91	319.0	COG1680@1|root,COG1680@2|Bacteria,1TR9E@1239|Firmicutes,2480P@186801|Clostridia,3WRFA@541000|Ruminococcaceae	186801|Clostridia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_364459_22	768671.ThimaDRAFT_2623	4.53e-29	124.0	COG4798@1|root,COG4798@2|Bacteria,1QUNP@1224|Proteobacteria,1S3N0@1236|Gammaproteobacteria,1WYE0@135613|Chromatiales	135613|Chromatiales	S	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_364459_21	880073.Calab_1754	2.015e-31	143.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.4,3.4.21.66	ko:K01179,ko:K08651	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH5,GH9	-	Autotransporter,PKD,Peptidase_S8,Peptidase_S8_N,fn3
CMS2_k127_364459_2	502025.Hoch_6312	7.598e-150	502.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_364459_26	1296416.JACB01000010_gene1606	2.717e-20	107.0	COG2207@1|root,COG2207@2|Bacteria,4NG1D@976|Bacteroidetes,1HY6X@117743|Flavobacteriia,2YKHD@290174|Aquimarina	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS2_k127_364459_4	1210884.HG799463_gene9356	2.719e-146	497.0	COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria,2J2QP@203682|Planctomycetes	203682|Planctomycetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Reg_prop,Y_Y_Y
CMS2_k127_364459_29	313612.L8106_25040	2.037e-17	86.0	28QHW@1|root,2ZCZW@2|Bacteria,1GG93@1117|Cyanobacteria,1HGM6@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_364459_19	555779.Dthio_PD0854	1.297e-34	136.0	COG1487@1|root,COG1487@2|Bacteria,1RHQJ@1224|Proteobacteria,42TEC@68525|delta/epsilon subdivisions,2WPE2@28221|Deltaproteobacteria,2MF3R@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_364459_31	555779.Dthio_PD0855	1.003e-09	63.0	2EC1X@1|root,33612@2|Bacteria,1NER9@1224|Proteobacteria,42W14@68525|delta/epsilon subdivisions,2WRP1@28221|Deltaproteobacteria,2MFQ4@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HicB
CMS2_k127_364459_28	1047013.AQSP01000068_gene2281	1.983e-17	96.0	28WP9@1|root,2ZINZ@2|Bacteria	1047013.AQSP01000068_gene2281|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_364459_0	555779.Dthio_PD1842	0.0	1348.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2M8T9@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	ATPase BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
CMS2_k127_364459_35	1121468.AUBR01000055_gene1426	9.24e-05	48.0	COG1848@1|root,COG1848@2|Bacteria,1VVM9@1239|Firmicutes,250X5@186801|Clostridia	186801|Clostridia	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_364459_30	1041826.FCOL_11695	1.223e-16	86.0	2CIH2@1|root,2ZTG0@2|Bacteria,4PMH9@976|Bacteroidetes,1IJT0@117743|Flavobacteriia,2NW19@237|Flavobacterium	976|Bacteroidetes	S	Putative lumazine-binding	-	-	-	-	-	-	-	-	-	-	-	-	Lumazine_bd_2
CMS2_k127_364459_15	313606.M23134_03302	6.281e-44	166.0	COG1595@1|root,COG1595@2|Bacteria,4NMYQ@976|Bacteroidetes,47PII@768503|Cytophagia	976|Bacteroidetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_364459_16	1121957.ATVL01000012_gene615	4.614e-38	153.0	COG1413@1|root,COG1413@2|Bacteria,4NIBA@976|Bacteroidetes,47M5K@768503|Cytophagia	976|Bacteroidetes	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,zf-HC2
CMS2_k127_364459_23	1279009.ADICEAN_02447	6.092e-25	115.0	COG3595@1|root,COG3595@2|Bacteria,4NJBA@976|Bacteroidetes,47MRP@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_364459_13	471854.Dfer_1128	1.754e-56	208.0	COG3595@1|root,COG3595@2|Bacteria,4NGRU@976|Bacteroidetes,47MSM@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS2_k127_364459_32	351627.Csac_0271	1.68e-09	59.0	COG0535@1|root,COG0535@2|Bacteria,1V1M4@1239|Firmicutes,24GYZ@186801|Clostridia	186801|Clostridia	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
CMS2_k127_364459_18	1047013.AQSP01000072_gene984	1.25e-35	147.0	COG2177@1|root,COG2177@2|Bacteria,2NPIM@2323|unclassified Bacteria	2|Bacteria	D	Belongs to the ABC-4 integral membrane protein family. FtsX subfamily	ftsX	GO:0005575,GO:0005618,GO:0005623,GO:0006928,GO:0008150,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0030312,GO:0030313,GO:0031975,GO:0040011,GO:0043207,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0071944,GO:0071976	-	ko:K09811,ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
CMS2_k127_364459_9	1047013.AQSP01000072_gene983	3.175e-68	239.0	COG2884@1|root,COG2884@2|Bacteria,2NP95@2323|unclassified Bacteria	2|Bacteria	D	ATPases associated with a variety of cellular activities	ftsE	GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531	-	ko:K09811,ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
CMS2_k127_364459_27	481448.Minf_1120	9.342e-20	98.0	COG1579@1|root,COG1579@2|Bacteria,46T10@74201|Verrucomicrobia,37GUU@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
CMS2_k127_364459_3	1047013.AQSP01000084_gene764	2.53e-147	499.0	COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase	dnaE-2	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
CMS2_k127_364459_1	694427.Palpr_0477	6.776e-153	492.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	iadA	-	-	ko:K01305	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Amidohydro_1,Amidohydro_3
CMS2_k127_364459_8	445335.CBN_2847	1.249e-68	252.0	COG0641@1|root,COG0641@2|Bacteria,1TT6S@1239|Firmicutes,248QW@186801|Clostridia,36FP9@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	ccpM	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
CMS2_k127_364459_10	1047013.AQSP01000051_gene2576	2.681e-65	246.0	COG2220@1|root,COG2220@2|Bacteria,2NRBH@2323|unclassified Bacteria	2|Bacteria	S	Beta-lactamase superfamily domain	folD4	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CMS2_k127_364459_14	452471.Aasi_0703	1.509e-49	198.0	COG0666@1|root,COG0666@2|Bacteria,4NEYY@976|Bacteroidetes,47MVD@768503|Cytophagia	976|Bacteroidetes	U	Ankyrin repeats (3 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5,SHOCT,SecA_DEAD
CMS2_k127_364459_11	1047013.AQSP01000051_gene2576	2.633e-64	243.0	COG2220@1|root,COG2220@2|Bacteria,2NRBH@2323|unclassified Bacteria	2|Bacteria	S	Beta-lactamase superfamily domain	folD4	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CMS2_k127_364459_17	72019.SARC_04650T0	1.323e-37	161.0	COG0666@1|root,KOG4177@2759|Eukaryota	2759|Eukaryota	I	spectrin binding	-	-	-	ko:K21440	-	-	-	-	ko00000,ko04131	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5,SPRY
CMS2_k127_364459_20	1158608.I583_01713	1.901e-31	134.0	COG1131@1|root,COG1131@2|Bacteria,1TPUP@1239|Firmicutes,4HC2V@91061|Bacilli,4B2E8@81852|Enterococcaceae	91061|Bacilli	V	AAA domain, putative AbiEii toxin, Type IV TA system	yhcG	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_364459_25	315730.BcerKBAB4_3907	2.802e-21	98.0	COG1725@1|root,COG1725@2|Bacteria,1VFD0@1239|Firmicutes,4HNIT@91061|Bacilli,1ZGQV@1386|Bacillus	91061|Bacilli	K	GntR family transcriptional regulator	ytrA	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS2_k127_364459_6	485916.Dtox_0608	3.402e-75	254.0	COG0432@1|root,COG0617@1|root,COG0432@2|Bacteria,COG0617@2|Bacteria,1V201@1239|Firmicutes,24FTY@186801|Clostridia,261SP@186807|Peptococcaceae	186801|Clostridia	J	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CMS2_k127_364459_7	338966.Ppro_2976	2.536e-71	246.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,42RKH@68525|delta/epsilon subdivisions,2WPJZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM isochorismatase hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS2_k127_364459_33	435838.HMPREF0786_01053	2.161e-06	60.0	COG3942@1|root,COG3942@2|Bacteria,1VCXB@1239|Firmicutes,4HMCB@91061|Bacilli,4GZ4H@90964|Staphylococcaceae	91061|Bacilli	S	COG3942 Surface antigen	p40	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	CHAP
CMS2_k127_364459_12	795359.TOPB45_0665	1.105e-60	227.0	COG2204@1|root,COG2204@2|Bacteria,2GHIR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_364459_34	1047013.AQSP01000097_gene1952	1.341e-05	57.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,TolB_like
CMS2_k127_364459_37	313606.M23134_00624	0.0003638	46.0	COG5464@1|root,COG5464@2|Bacteria,4NJT2@976|Bacteroidetes,47K3M@768503|Cytophagia	976|Bacteroidetes	S	PD-(D/E)XK nuclease family transposase	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_3645042_1	237368.SCABRO_02364	5.067e-207	652.0	COG0286@1|root,COG0286@2|Bacteria,2IXEQ@203682|Planctomycetes	203682|Planctomycetes	V	COG0286 Type I restriction-modification system	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
CMS2_k127_3645042_0	237368.SCABRO_02360	0.0	1131.0	COG4096@1|root,COG4096@2|Bacteria,2IYGW@203682|Planctomycetes	203682|Planctomycetes	L	DEAD-like helicases superfamily	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,Helicase_C,ResIII
CMS2_k127_3645042_2	1047013.AQSP01000070_gene41	2.183e-43	162.0	COG1487@1|root,COG1487@2|Bacteria,2NRNI@2323|unclassified Bacteria	2|Bacteria	S	Large family of predicted nucleotide-binding domains	vapC	GO:0001666,GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0036293,GO:0040008,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0070482,GO:0071704,GO:0075136,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_3645042_3	113355.CM001775_gene2831	8.298e-19	87.0	COG5450@1|root,COG5450@2|Bacteria,1G97S@1117|Cyanobacteria	1117|Cyanobacteria	K	protein conserved in bacteria (DUF2191)	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
CMS2_k127_3645042_4	269797.Mbar_A1684	2.263e-12	76.0	arCOG02498@1|root,arCOG02526@1|root,arCOG02498@2157|Archaea,arCOG02526@2157|Archaea,2Y0XD@28890|Euryarchaeota	28890|Euryarchaeota	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	NosD
CMS2_k127_3649453_1	573061.Clocel_2482	5.237e-290	936.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3649453_5	756067.MicvaDRAFT_2507	1.643e-107	370.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H837@1150|Oscillatoriales	1117|Cyanobacteria	Q	Non-ribosomal peptide synthetase modules and related	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Formyl_trans_N,Methyltransf_12,PP-binding,PilZ
CMS2_k127_3649453_2	118005.AWNK01000004_gene1064	1.766e-270	903.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3649453_0	536232.CLM_0373	0.0	2739.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3649453_4	46234.ANA_C11361	6.602e-161	520.0	2EP1D@1|root,33GN8@2|Bacteria,1GCCG@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3649453_3	46234.ANA_C11362	1.17e-169	544.0	COG0641@1|root,COG0641@2|Bacteria,1GAI2@1117|Cyanobacteria	1117|Cyanobacteria	C	Radical SAM additional 4Fe4S-binding domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS2_k127_3653761_5	5722.XP_001309954.1	4.843e-25	113.0	COG0125@1|root,KOG3327@2759|Eukaryota	2759|Eukaryota	F	dTDP metabolic process	DTYMK	GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004550,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005759,GO:0005829,GO:0006139,GO:0006165,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0008283,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010033,GO:0010154,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0022414,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0031981,GO:0032501,GO:0032502,GO:0034641,GO:0034654,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046939,GO:0046940,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0050145,GO:0050896,GO:0051716,GO:0055086,GO:0061458,GO:0070013,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
CMS2_k127_3653761_3	237368.SCABRO_03266	6.17e-37	158.0	COG0451@1|root,COG0451@2|Bacteria,2IYNU@203682|Planctomycetes	203682|Planctomycetes	M	COG0451 Nucleoside-diphosphate-sugar	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
CMS2_k127_3653761_2	313628.LNTAR_02457	2.12e-41	161.0	COG4894@1|root,COG4894@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K21429	-	-	-	-	ko00000,ko01002	-	-	-	LOR
CMS2_k127_3653761_1	555779.Dthio_PD1468	1.837e-81	284.0	COG1271@1|root,COG1271@2|Bacteria,1QXQF@1224|Proteobacteria,42NKJ@68525|delta/epsilon subdivisions,2WKHM@28221|Deltaproteobacteria,2M95S@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	oxidase subunit	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	-
CMS2_k127_3653761_0	1123376.AUIU01000011_gene1083	0.0	1041.0	COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
CMS2_k127_3653761_7	1423780.LOT_1699	3.995e-05	50.0	COG4977@1|root,COG4977@2|Bacteria,1UIVE@1239|Firmicutes,4ITAQ@91061|Bacilli,3F68N@33958|Lactobacillaceae	91061|Bacilli	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
CMS2_k127_3653761_6	565045.NOR51B_1609	2.86e-18	91.0	COG2849@1|root,COG2849@2|Bacteria,1MZCG@1224|Proteobacteria,1SCIQ@1236|Gammaproteobacteria,1J79G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2
CMS2_k127_3653761_4	760192.Halhy_1128	1.472e-30	133.0	COG3209@1|root,COG3209@2|Bacteria,4NFUE@976|Bacteroidetes,1INSI@117747|Sphingobacteriia	976|Bacteroidetes	M	COG3209 Rhs family protein	rhsA	-	-	-	-	-	-	-	-	-	-	-	RHS,RHS_repeat
CMS2_k127_3654224_38	1047013.AQSP01000142_gene225	2.462e-06	59.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	ywhL	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
CMS2_k127_3654224_4	1168034.FH5T_01575	2.47e-185	591.0	COG1520@1|root,COG1520@2|Bacteria,4P15Y@976|Bacteroidetes,2FWBU@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2
CMS2_k127_3654224_25	1168034.FH5T_01570	6.646e-53	199.0	COG3391@1|root,COG3391@2|Bacteria,4PC69@976|Bacteroidetes,2G01G@200643|Bacteroidia	976|Bacteroidetes	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3654224_21	1168034.FH5T_01560	4.377e-66	231.0	2DVMZ@1|root,33WFQ@2|Bacteria,4P3VR@976|Bacteroidetes,2FXVM@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_3654224_11	1168034.FH5T_01555	2.752e-121	407.0	COG0348@1|root,COG0348@2|Bacteria,4NPVD@976|Bacteroidetes,2FTEY@200643|Bacteroidia	976|Bacteroidetes	C	FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
CMS2_k127_3654224_7	1168034.FH5T_01550	7.716e-137	454.0	COG1520@1|root,COG1520@2|Bacteria,4P1VG@976|Bacteroidetes,2FW8D@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_3654224_0	1168034.FH5T_01545	1.98e-304	952.0	COG1894@1|root,COG1894@2|Bacteria,4NFB5@976|Bacteroidetes,2FN7A@200643|Bacteroidia	976|Bacteroidetes	C	COG1894 NADH ubiquinone oxidoreductase, NADH-binding (51 kD) subunit	nuoF	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
CMS2_k127_3654224_6	1168034.FH5T_01535	6.515e-149	506.0	COG0493@1|root,COG0493@2|Bacteria,4P2CU@976|Bacteroidetes,2FXPN@200643|Bacteroidia	976|Bacteroidetes	E	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4_20
CMS2_k127_3654224_22	756272.Plabr_2035	7.221e-65	252.0	COG1520@1|root,COG1520@2|Bacteria,2IYZY@203682|Planctomycetes	203682|Planctomycetes	S	protein kinase related protein	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS2_k127_3654224_12	1168034.FH5T_01525	3.701e-117	392.0	COG0438@1|root,COG0438@2|Bacteria,4P10Z@976|Bacteroidetes	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
CMS2_k127_3654224_35	1094980.Mpsy_2997	6.625e-15	79.0	COG1598@1|root,arCOG02411@2157|Archaea	2157|Archaea	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
CMS2_k127_3654224_23	1210884.HG799474_gene15182	1.546e-64	228.0	COG1136@1|root,COG1136@2|Bacteria,2IZ2X@203682|Planctomycetes	203682|Planctomycetes	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	-	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
CMS2_k127_3654224_1	497964.CfE428DRAFT_4943	4.719e-246	797.0	COG0577@1|root,COG0577@2|Bacteria,46U6N@74201|Verrucomicrobia	74201|Verrucomicrobia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
CMS2_k127_3654224_5	1168034.FH5T_18840	4.222e-150	486.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_3654224_24	1278073.MYSTI_03221	6.105e-61	229.0	COG0664@1|root,COG3264@1|root,COG0664@2|Bacteria,COG3264@2|Bacteria,1QX62@1224|Proteobacteria,42S57@68525|delta/epsilon subdivisions,2WNY0@28221|Deltaproteobacteria,2YVPP@29|Myxococcales	28221|Deltaproteobacteria	MT	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,cNMP_binding
CMS2_k127_3654224_3	880073.Calab_0633	9.813e-200	630.0	COG2403@1|root,COG2403@2|Bacteria,2NNTB@2323|unclassified Bacteria	2|Bacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	cpgS	-	-	ko:K05716	-	-	R03298	RC00900	ko00000,ko01000	-	-	-	cobW
CMS2_k127_3654224_14	1232437.KL662001_gene4587	2.204e-102	352.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2MHY5@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
CMS2_k127_3654224_30	697303.Thewi_0606	1.599e-21	100.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,42GXN@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Uncharacterised protein family UPF0079, ATPase	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
CMS2_k127_3654224_34	1089549.AZUQ01000001_gene853	2.55e-15	79.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4EYYH@85014|Glycomycetales	201174|Actinobacteria	O	Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS2_k127_3654224_31	314230.DSM3645_29481	4.923e-20	103.0	COG0526@1|root,COG0526@2|Bacteria,2J35Z@203682|Planctomycetes	203682|Planctomycetes	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
CMS2_k127_3654224_20	1499967.BAYZ01000073_gene2049	3.302e-66	253.0	COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,Sulfatase
CMS2_k127_3654224_36	1047013.AQSP01000132_gene1736	6.651e-15	88.0	28WP9@1|root,2ZINZ@2|Bacteria	1047013.AQSP01000132_gene1736|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3654224_15	1121396.KB892957_gene3255	6.299e-92	313.0	COG2199@1|root,COG3706@2|Bacteria,1R2H3@1224|Proteobacteria,43DDN@68525|delta/epsilon subdivisions,2X8JF@28221|Deltaproteobacteria,2MI5V@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Membrane-associated sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	MASE3
CMS2_k127_3654224_33	1408433.JHXV01000023_gene3331	5.865e-16	87.0	28N78@1|root,2ZBBY@2|Bacteria,4NGF9@976|Bacteroidetes,1I65K@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4932
CMS2_k127_3654224_8	639282.DEFDS_2122	4.792e-133	436.0	COG0104@1|root,COG0104@2|Bacteria,2GEUU@200930|Deferribacteres	200930|Deferribacteres	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
CMS2_k127_3654224_27	517418.Ctha_0870	1.032e-49	194.0	COG0642@1|root,COG2205@2|Bacteria	517418.Ctha_0870|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3654224_37	797209.ZOD2009_17850	2.533e-08	65.0	arCOG08099@1|root,arCOG08099@2157|Archaea,2Y8AQ@28890|Euryarchaeota,2417K@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3654224_2	525897.Dbac_3117	2.567e-210	674.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2M7VB@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
CMS2_k127_3654224_29	1382359.JIAL01000001_gene1949	1.025e-24	109.0	COG2001@1|root,COG2001@2|Bacteria,3Y4NF@57723|Acidobacteria,2JJA0@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
CMS2_k127_3654224_10	1047013.AQSP01000140_gene2481	7.215e-123	413.0	COG0768@1|root,COG0768@2|Bacteria,2NNWR@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.4.16.4	ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
CMS2_k127_3654224_13	373903.Hore_09040	9.747e-103	351.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,3WBB1@53433|Halanaerobiales	186801|Clostridia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS2_k127_3654224_19	1047013.AQSP01000140_gene2479	7.89e-67	246.0	COG0770@1|root,COG0770@2|Bacteria,2NP4Q@2323|unclassified Bacteria	2|Bacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10,6.3.2.13	ko:K01929,ko:K15792	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R02788,R04573,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS2_k127_3654224_16	868595.Desca_2344	5.797e-85	300.0	COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,260PC@186807|Peptococcaceae	186801|Clostridia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
CMS2_k127_3654224_17	1047013.AQSP01000140_gene2476	1.268e-74	264.0	COG0772@1|root,COG0772@2|Bacteria,2NP3P@2323|unclassified Bacteria	2|Bacteria	D	Belongs to the SEDS family	ftsW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28	-	FTSW_RODA_SPOVE
CMS2_k127_3654224_9	1232410.KI421421_gene3865	2.301e-129	427.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,43T1G@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	UDP-N-acetylmuramate-L-alanine ligase activity	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS2_k127_3654224_32	1047013.AQSP01000140_gene2473	1.776e-16	89.0	COG1589@1|root,COG1589@2|Bacteria	2|Bacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	divIB	-	-	ko:K03589,ko:K06438	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
CMS2_k127_3654224_18	1047013.AQSP01000140_gene2472	2.229e-71	247.0	COG0849@1|root,COG0849@2|Bacteria,2NNU2@2323|unclassified Bacteria	2|Bacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
CMS2_k127_3670824_0	439235.Dalk_5087	9.731e-161	516.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales	1224|Proteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
CMS2_k127_3670824_2	351627.Csac_1174	0.0004221	50.0	COG3209@1|root,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia,42HP8@68295|Thermoanaerobacterales	186801|Clostridia	M	TIGRFAM YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4280,RHS_repeat
CMS2_k127_3670824_1	82654.Pse7367_2629	9.406e-36	157.0	COG3209@1|root,COG3210@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria,1G4PY@1117|Cyanobacteria,1HEZB@1150|Oscillatoriales	1117|Cyanobacteria	M	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
CMS2_k127_3671160_4	909663.KI867150_gene1603	5.635e-96	325.0	COG0077@1|root,COG0077@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2WJET@28221|Deltaproteobacteria,2MR0Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Chorismate mutase type II	pheA	-	4.2.1.51,5.4.99.5	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
CMS2_k127_3671160_2	1499967.BAYZ01000181_gene4498	4.923e-122	396.0	COG2876@1|root,COG2876@2|Bacteria,2NNPG@2323|unclassified Bacteria	2|Bacteria	E	PFAM DAHP synthetase I KDSA	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
CMS2_k127_3671160_3	1121405.dsmv_0804	3.795e-117	385.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WJKR@28221|Deltaproteobacteria,2MIGY@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
CMS2_k127_3671160_6	909663.KI867150_gene1599	2.161e-55	203.0	COG0710@1|root,COG0710@2|Bacteria,1NG0G@1224|Proteobacteria,42W3S@68525|delta/epsilon subdivisions,2WRJE@28221|Deltaproteobacteria,2MQQ7@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
CMS2_k127_3671160_7	411489.CLOL250_02925	2.297e-54	207.0	COG0169@1|root,COG0703@1|root,COG0169@2|Bacteria,COG0703@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,36E3G@31979|Clostridiaceae	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS14185,iHN637.CLJU_RS14365	CM_2,SKI,Shikimate_DH,Shikimate_dh_N
CMS2_k127_3671160_1	903818.KI912269_gene322	7.229e-127	419.0	COG0128@1|root,COG0128@2|Bacteria,3Y3RH@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
CMS2_k127_3671160_0	909663.KI867150_gene1602	1.339e-140	452.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,42MF9@68525|delta/epsilon subdivisions,2WJ57@28221|Deltaproteobacteria,2MQCX@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
CMS2_k127_3671160_5	1047013.AQSP01000140_gene2501	1.696e-55	203.0	COG3595@1|root,COG3595@2|Bacteria,2NRA5@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS2_k127_3671160_9	644281.MFS40622_0796	9.691e-22	96.0	COG2026@1|root,arCOG01663@2157|Archaea,2Y58U@28890|Euryarchaeota	28890|Euryarchaeota	K	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
CMS2_k127_3671160_8	1047013.AQSP01000128_gene446	1.501e-39	149.0	COG1180@1|root,COG1180@2|Bacteria,2NNMV@2323|unclassified Bacteria	2|Bacteria	O	Elongator protein 3, MiaB family, Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS2_k127_3695640_40	1279009.ADICEAN_01242	0.0004295	47.0	2CG2C@1|root,3396W@2|Bacteria,4NWWU@976|Bacteroidetes,47S7F@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3695640_17	1408322.JHYK01000026_gene31	1.608e-56	205.0	COG1028@1|root,COG1211@1|root,COG1028@2|Bacteria,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,27T7W@186928|unclassified Lachnospiraceae	186801|Clostridia	I	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	ispD	-	2.7.7.40,2.7.7.60	ko:K00991,ko:K21030	ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130	M00096	R02921,R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
CMS2_k127_3695640_14	580327.Tthe_0073	2.882e-84	283.0	COG2818@1|root,COG2818@2|Bacteria,1UYWG@1239|Firmicutes,249EP@186801|Clostridia,42FGP@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
CMS2_k127_3695640_21	643562.Daes_0336	1.344e-49	182.0	COG3542@1|root,COG3542@2|Bacteria,1RHBE@1224|Proteobacteria,42T2P@68525|delta/epsilon subdivisions,2WPQ3@28221|Deltaproteobacteria,2MBSS@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
CMS2_k127_3695640_6	204536.SULAZ_0405	4.776e-131	432.0	COG0277@1|root,COG0277@2|Bacteria,2G3NK@200783|Aquificae	200783|Aquificae	C	FAD linked oxidase domain protein	-	-	1.1.3.15,1.1.5.12	ko:K00104,ko:K03777	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00475,R00704,R11591	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
CMS2_k127_3695640_42	1120951.AUBG01000005_gene2216	0.0006641	50.0	COG0664@1|root,COG0745@1|root,COG0664@2|Bacteria,COG0745@2|Bacteria,4NFB1@976|Bacteroidetes,1HY0Y@117743|Flavobacteriia	976|Bacteroidetes	T	transcriptional regulator	crp	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,Response_reg,cNMP_binding
CMS2_k127_3695640_34	929556.Solca_3150	1.713e-20	95.0	COG4551@1|root,COG4551@2|Bacteria,4NSDW@976|Bacteroidetes	976|Bacteroidetes	S	Low molecular weight phosphotyrosine protein phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3695640_24	177439.DP0552	4.65e-39	157.0	COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,42QVG@68525|delta/epsilon subdivisions,2WNKA@28221|Deltaproteobacteria,2MJNQ@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS2_k127_3695640_31	373994.Riv7116_3340	2.269e-23	117.0	COG0457@1|root,COG5635@1|root,COG0457@2|Bacteria,COG5635@2|Bacteria,1G2Q8@1117|Cyanobacteria,1HRWI@1161|Nostocales	1117|Cyanobacteria	T	Soluble NSF attachment protein, SNAP	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,TPR_12,TPR_8
CMS2_k127_3695640_5	1004149.AFOE01000006_gene2010	8.219e-148	495.0	COG0793@1|root,COG0793@2|Bacteria,4NEK8@976|Bacteroidetes,1HYIK@117743|Flavobacteriia	976|Bacteroidetes	M	peptidase S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
CMS2_k127_3695640_7	1121904.ARBP01000006_gene3734	6.653e-131	425.0	COG0388@1|root,COG0388@2|Bacteria,4NGH7@976|Bacteroidetes,47JFF@768503|Cytophagia	976|Bacteroidetes	S	Carbon-nitrogen hydrolase	-	-	3.5.5.1	ko:K01501	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
CMS2_k127_3695640_18	215803.DB30_1101	2.36e-51	196.0	2DFQT@1|root,32U5Y@2|Bacteria,1MZ5S@1224|Proteobacteria,42UEJ@68525|delta/epsilon subdivisions,2WQUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3695640_8	717231.Flexsi_0219	1.446e-119	395.0	COG0116@1|root,COG0116@2|Bacteria,2GFKC@200930|Deferribacteres	200930|Deferribacteres	L	THUMP	-	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	UPF0020
CMS2_k127_3695640_3	1121957.ATVL01000007_gene1905	7.723e-169	555.0	COG0793@1|root,COG0793@2|Bacteria,4NFK4@976|Bacteroidetes,47KAN@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
CMS2_k127_3695640_11	913865.DOT_2962	2.19e-93	314.0	COG0204@1|root,COG0204@2|Bacteria,1U51E@1239|Firmicutes	1239|Firmicutes	I	Acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS2_k127_3695640_1	1047013.AQSP01000077_gene2274	2.278e-207	653.0	COG0247@1|root,COG0247@2|Bacteria	2|Bacteria	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8,Fer4_9
CMS2_k127_3695640_23	1047013.AQSP01000093_gene13	1.018e-42	164.0	COG2181@1|root,COG2181@2|Bacteria	2|Bacteria	C	nitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	SLAC1
CMS2_k127_3695640_20	1047013.AQSP01000093_gene14	3.434e-51	183.0	COG2920@1|root,COG2920@2|Bacteria,2NQ6I@2323|unclassified Bacteria	2|Bacteria	P	DsrC like protein	dsrC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
CMS2_k127_3695640_0	179408.Osc7112_5096	0.0	1321.0	COG0515@1|root,COG0745@1|root,COG2203@1|root,COG3899@1|root,COG5002@1|root,COG0515@2|Bacteria,COG0745@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG5002@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales	1117|Cyanobacteria	KLT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,HATPase_c,HisKA,PAS_3,Pkinase,Response_reg
CMS2_k127_3695640_33	880073.Calab_1859	1.395e-20	95.0	COG0640@1|root,COG0640@2|Bacteria,2NQ1G@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
CMS2_k127_3695640_4	525897.Dbac_1904	2.788e-153	493.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42N6E@68525|delta/epsilon subdivisions,2WJXG@28221|Deltaproteobacteria,2M9VF@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
CMS2_k127_3695640_30	891968.Anamo_2065	4.087e-27	111.0	COG0526@1|root,COG0526@2|Bacteria,3TBM2@508458|Synergistetes	508458|Synergistetes	CO	redox-active disulfide protein 2	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
CMS2_k127_3695640_25	641491.DND132_2314	6.967e-37	143.0	COG4273@1|root,COG4273@2|Bacteria,1MZED@1224|Proteobacteria,42UH2@68525|delta/epsilon subdivisions,2WQNQ@28221|Deltaproteobacteria,2MBB6@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	DGC domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DGC
CMS2_k127_3695640_2	1047013.AQSP01000092_gene323	1.638e-189	598.0	COG0798@1|root,COG0798@2|Bacteria,2NNWJ@2323|unclassified Bacteria	2|Bacteria	P	Sodium Bile acid symporter family	arsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
CMS2_k127_3695640_43	1144275.COCOR_01477	0.0007715	52.0	28VZ3@1|root,2ZI0A@2|Bacteria,1P5AK@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3695640_22	1198452.Jab_2c07120	3.906e-44	182.0	COG1404@1|root,COG1404@2|Bacteria,1Q0N6@1224|Proteobacteria,2W5HH@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3695640_28	1270196.JCKI01000001_gene3844	5.089e-32	142.0	2C5U1@1|root,2Z80K@2|Bacteria,4NG4G@976|Bacteroidetes,1IQ1S@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3695640_13	1232437.KL661958_gene2898	4.415e-87	298.0	COG2159@1|root,COG2159@2|Bacteria,1QA25@1224|Proteobacteria,430IB@68525|delta/epsilon subdivisions,2WSMC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
CMS2_k127_3695640_16	1201290.M902_1566	9.389e-61	218.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2MSVB@213481|Bdellovibrionales,2WMYC@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
CMS2_k127_3695640_15	1157490.EL26_13370	2.745e-75	263.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,4HAE2@91061|Bacilli,27893@186823|Alicyclobacillaceae	91061|Bacilli	C	Electron transfer flavoprotein FAD-binding domain	etfA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
CMS2_k127_3695640_9	694427.Palpr_0065	1.827e-100	337.0	COG0524@1|root,COG0524@2|Bacteria,4NIHI@976|Bacteroidetes,2FPRJ@200643|Bacteroidia,22WDP@171551|Porphyromonadaceae	976|Bacteroidetes	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CMS2_k127_3695640_39	1121403.AUCV01000002_gene607	0.0003164	47.0	COG2198@1|root,COG2198@2|Bacteria,1NBYP@1224|Proteobacteria	1224|Proteobacteria	T	(Hpt) domain	hptB	-	-	ko:K20976	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Hpt
CMS2_k127_3695640_27	1208321.D104_15465	1.644e-33	132.0	COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,1S66E@1236|Gammaproteobacteria,1XJX4@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
CMS2_k127_3695640_10	1231241.Mc24_06150	2.87e-97	326.0	COG0414@1|root,COG0414@2|Bacteria,2GC24@200918|Thermotogae	200918|Thermotogae	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
CMS2_k127_3695640_12	580331.Thit_0447	5.216e-92	310.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,42FEE@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
CMS2_k127_3695640_19	1047013.AQSP01000096_gene2179	2.807e-51	188.0	COG1428@1|root,COG1428@2|Bacteria,2NPEH@2323|unclassified Bacteria	2|Bacteria	F	Deoxynucleoside kinase	dgk	-	2.7.1.113	ko:K15518	ko00230,map00230	-	R01967	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HPPK,dNK
CMS2_k127_3695640_37	1123511.KB905847_gene3058	1.144e-08	62.0	COG1396@1|root,COG1396@2|Bacteria,1UWN4@1239|Firmicutes,4H62S@909932|Negativicutes	909932|Negativicutes	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS2_k127_3695640_29	176280.SE_1801	1.352e-27	117.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,4HKF4@91061|Bacilli,4GZNY@90964|Staphylococcaceae	91061|Bacilli	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
CMS2_k127_3695640_36	324925.Ppha_2425	4.587e-11	73.0	2E9II@1|root,333RI@2|Bacteria,1FEZP@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3695640_32	290512.Paes_2210	1.327e-21	103.0	2EDYH@1|root,337TB@2|Bacteria,1FEFX@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3695640_26	756067.MicvaDRAFT_4950	9.566e-36	139.0	COG3744@1|root,COG3744@2|Bacteria,1G89Q@1117|Cyanobacteria,1HCN7@1150|Oscillatoriales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_3696472_40	195250.CM001776_gene1111	5.708e-60	218.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS2_k127_3696472_18	1304885.AUEY01000046_gene3	1.474e-95	322.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,42Q9R@68525|delta/epsilon subdivisions,2WKU4@28221|Deltaproteobacteria,2MIVX@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
CMS2_k127_3696472_27	1499967.BAYZ01000026_gene1647	4.648e-82	283.0	COG0484@1|root,COG0484@2|Bacteria,2NQI8@2323|unclassified Bacteria	2|Bacteria	O	DnaJ molecular chaperone homology domain	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
CMS2_k127_3696472_50	926692.AZYG01000071_gene2742	2.592e-47	179.0	2DVIZ@1|root,33W47@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3696472_5	886293.Sinac_6154	1.537e-157	527.0	COG2866@1|root,COG2866@2|Bacteria,2IXPH@203682|Planctomycetes	203682|Planctomycetes	E	PFAM Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS2_k127_3696472_23	697303.Thewi_1741	1.287e-89	304.0	COG1313@1|root,COG1313@2|Bacteria,1TRUV@1239|Firmicutes,247VW@186801|Clostridia,42FFV@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Radical SAM domain protein	PflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
CMS2_k127_3696472_29	439235.Dalk_0237	4.894e-81	302.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_3696472_17	1173028.ANKO01000129_gene1998	7.336e-102	366.0	COG1785@1|root,COG1785@2|Bacteria,1G4BJ@1117|Cyanobacteria	1117|Cyanobacteria	P	Alkaline phosphatase	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
CMS2_k127_3696472_38	1121904.ARBP01000005_gene4791	2.177e-62	223.0	COG2220@1|root,COG2220@2|Bacteria,4P6X9@976|Bacteroidetes	976|Bacteroidetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CMS2_k127_3696472_14	880073.Calab_2787	1.581e-106	352.0	COG0846@1|root,COG0846@2|Bacteria	2|Bacteria	K	NAD+ binding	srtN	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
CMS2_k127_3696472_8	1047013.AQSP01000142_gene193	1.013e-142	465.0	COG0534@1|root,COG0534@2|Bacteria,2NPFE@2323|unclassified Bacteria	2|Bacteria	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	ANKH,MatE
CMS2_k127_3696472_26	401526.TcarDRAFT_2185	1.666e-82	284.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4H21S@909932|Negativicutes	909932|Negativicutes	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
CMS2_k127_3696472_30	1379698.RBG1_1C00001G0533	5.093e-79	277.0	COG0454@1|root,COG0456@2|Bacteria,2NNUP@2323|unclassified Bacteria	2|Bacteria	K	acetyltransferase	yghO	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_3696472_48	56780.SYN_00882	9.309e-49	198.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
CMS2_k127_3696472_78	313596.RB2501_12492	4.731e-15	89.0	COG0457@1|root,COG2197@1|root,COG0457@2|Bacteria,COG2197@2|Bacteria,4NGS0@976|Bacteroidetes,1HZ2N@117743|Flavobacteriia	976|Bacteroidetes	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	GerE,TPR_10,TPR_12,TPR_8
CMS2_k127_3696472_60	760568.Desku_3019	4.411e-25	105.0	COG1418@1|root,COG1418@2|Bacteria,1V4Z1@1239|Firmicutes,24I7X@186801|Clostridia	186801|Clostridia	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3696472_70	536227.CcarbDRAFT_2961	5.447e-18	92.0	2C5Z2@1|root,32A20@2|Bacteria,1V5CS@1239|Firmicutes,24M7C@186801|Clostridia,36H6C@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
CMS2_k127_3696472_4	1540257.JQMW01000011_gene1821	5.059e-162	531.0	COG1018@1|root,COG3894@1|root,COG1018@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,36DDZ@31979|Clostridiaceae	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
CMS2_k127_3696472_56	177437.HRM2_33680	7.093e-27	126.0	28M0D@1|root,2ZAFE@2|Bacteria,1R6YH@1224|Proteobacteria,42NPF@68525|delta/epsilon subdivisions,2WM7K@28221|Deltaproteobacteria,2MIG7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative ATP-binding cassette	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
CMS2_k127_3696472_43	645991.Sgly_2003	3.266e-52	194.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,261DY@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990,ko:K16907	ko02010,map02010	M00224,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_3696472_0	589865.DaAHT2_1333	9.674e-306	996.0	COG0745@1|root,COG0784@1|root,COG2203@1|root,COG2770@1|root,COG3437@1|root,COG4251@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2770@2|Bacteria,COG3437@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria,43BZ2@68525|delta/epsilon subdivisions,2X79T@28221|Deltaproteobacteria,2MPN3@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
CMS2_k127_3696472_11	485916.Dtox_3785	2.825e-117	384.0	COG1352@1|root,COG1352@2|Bacteria,1TRTF@1239|Firmicutes,24D04@186801|Clostridia,261HW@186807|Peptococcaceae	186801|Clostridia	NT	PFAM CheR methyltransferase, SAM binding domain	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
CMS2_k127_3696472_36	1121472.AQWN01000003_gene1591	1.28e-64	228.0	COG2201@1|root,COG2201@2|Bacteria,1VUR7@1239|Firmicutes,2505U@186801|Clostridia,2650Y@186807|Peptococcaceae	186801|Clostridia	NT	CheB methylesterase	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest
CMS2_k127_3696472_12	1167006.UWK_01589	4.601e-116	393.0	COG2199@1|root,COG3437@1|root,COG3437@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	2.7.7.65	ko:K13069	-	-	R08057	-	ko00000,ko01000	-	-	-	GGDEF,Protoglobin
CMS2_k127_3696472_39	237368.SCABRO_00579	1.517e-60	220.0	COG1639@1|root,COG1639@2|Bacteria,2J0A1@203682|Planctomycetes	203682|Planctomycetes	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
CMS2_k127_3696472_37	439235.Dalk_2974	1.137e-63	226.0	COG0642@1|root,COG2199@1|root,COG3437@1|root,COG0642@2|Bacteria,COG3437@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43BSG@68525|delta/epsilon subdivisions,2WK8V@28221|Deltaproteobacteria,2MHZC@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
CMS2_k127_3696472_35	316067.Geob_3737	3.044e-68	239.0	COG3809@1|root,COG3809@2|Bacteria,1P0JI@1224|Proteobacteria,432XD@68525|delta/epsilon subdivisions,2WY3I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
CMS2_k127_3696472_21	933262.AXAM01000018_gene1009	2.081e-93	329.0	COG0501@1|root,COG3063@1|root,COG0501@2|Bacteria,COG3063@2|Bacteria,1R5A7@1224|Proteobacteria,42MP6@68525|delta/epsilon subdivisions,2WK92@28221|Deltaproteobacteria,2MIHI@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_11,TPR_17
CMS2_k127_3696472_61	457570.Nther_1894	1.064e-24	109.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_3696472_81	411154.GFO_1857	1.244e-11	78.0	COG3595@1|root,COG3595@2|Bacteria,4NEUW@976|Bacteroidetes,1HYD6@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3696472_33	1168034.FH5T_11960	2.288e-75	259.0	COG4122@1|root,COG4122@2|Bacteria,4NNYP@976|Bacteroidetes	976|Bacteroidetes	M	tRNA methyltransferase complex GCD14 subunit	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
CMS2_k127_3696472_2	1047013.AQSP01000105_gene1439	7.65e-195	617.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	MA20_31530	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
CMS2_k127_3696472_10	1047013.AQSP01000089_gene1176	3.524e-122	410.0	COG2866@1|root,COG2866@2|Bacteria,2NQT6@2323|unclassified Bacteria	2|Bacteria	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS2_k127_3696472_9	1047013.AQSP01000135_gene1608	2.135e-137	457.0	COG1080@1|root,COG1080@2|Bacteria,2NNQF@2323|unclassified Bacteria	2|Bacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
CMS2_k127_3696472_64	1123073.KB899243_gene812	2.525e-21	96.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SCXX@1236|Gammaproteobacteria,1X7PU@135614|Xanthomonadales	135614|Xanthomonadales	G	phosphocarrier protein HPr	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
CMS2_k127_3696472_67	118005.AWNK01000011_gene163	1.387e-19	93.0	COG2893@1|root,COG2893@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	manX	-	2.7.1.191,2.7.1.194	ko:K02793,ko:K02794,ko:K02821	ko00051,ko00053,ko00520,ko01100,ko01120,ko02060,map00051,map00053,map00520,map01100,map01120,map02060	M00276,M00283,M00550	R02630,R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1,4.A.7.1	-	-	EIIA-man
CMS2_k127_3696472_41	272558.10176214	1.474e-58	214.0	COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,4HAXR@91061|Bacilli,1ZD05@1386|Bacillus	91061|Bacilli	F	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	hprK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
CMS2_k127_3696472_79	526218.Sterm_1968	9.541e-15	80.0	COG1762@1|root,COG1762@2|Bacteria,37CWF@32066|Fusobacteria	2|Bacteria	GT	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	fruA	-	2.7.1.194,2.7.1.195,2.7.1.200,2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02806,ko:K02821,ko:K03491,ko:K11198,ko:K11199,ko:K11200	ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060	M00273,M00279,M00283,M00305,M00550	R03232,R05570,R07671,R11169	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	4.A.2.1,4.A.2.1.3,4.A.5.1,4.A.7.1	-	-	HTH_11,Mga,PRD,PTS_EIIA_2,PTS_IIB
CMS2_k127_3696472_84	1382358.JHVN01000009_gene3376	5.024e-07	59.0	COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,4HFX9@91061|Bacilli,21V75@150247|Anoxybacillus	91061|Bacilli	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
CMS2_k127_3696472_32	697303.Thewi_1691	3.312e-76	273.0	COG1508@1|root,COG1508@2|Bacteria,1TQ0H@1239|Firmicutes,2480F@186801|Clostridia,42EW5@68295|Thermoanaerobacterales	186801|Clostridia	K	RNA polymerase sigma-54 factor	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
CMS2_k127_3696472_28	868864.Dester_1167	8.135e-82	278.0	COG1137@1|root,COG1137@2|Bacteria,2G3WA@200783|Aquificae	200783|Aquificae	S	ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
CMS2_k127_3696472_45	313606.M23134_01323	6.778e-51	188.0	COG1595@1|root,COG1595@2|Bacteria,4NQTP@976|Bacteroidetes,47QT5@768503|Cytophagia	976|Bacteroidetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_3696472_71	247490.KSU1_C1352	7.46e-18	95.0	COG2204@1|root,COG2204@2|Bacteria,2IYIG@203682|Planctomycetes	203682|Planctomycetes	T	CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_3696472_75	1120973.AQXL01000124_gene2338	4.36e-17	93.0	COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,4HA3V@91061|Bacilli,278RR@186823|Alicyclobacillaceae	91061|Bacilli	K	helix_turn_helix, Lux Regulon	degU	-	-	ko:K02479,ko:K07692	ko02020,ko02024,map02020,map02024	M00478	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
CMS2_k127_3696472_55	1303518.CCALI_02592	1.183e-30	139.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Response_reg,dCache_1
CMS2_k127_3696472_76	177437.HRM2_38210	1.097e-15	89.0	COG2204@1|root,COG2204@2|Bacteria,1P58Q@1224|Proteobacteria,430GN@68525|delta/epsilon subdivisions,2WVMH@28221|Deltaproteobacteria,2MKSV@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_3696472_65	1078083.HMPREF1208_01215	4.899e-20	102.0	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,4HA4B@91061|Bacilli,4GXZY@90964|Staphylococcaceae	91061|Bacilli	K	response regulator	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
CMS2_k127_3696472_52	1121918.ARWE01000001_gene2735	6.317e-38	146.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,42URG@68525|delta/epsilon subdivisions,2WNDG@28221|Deltaproteobacteria,43V0S@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Glyoxalase-like domain	mceE	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
CMS2_k127_3696472_72	643562.Daes_2201	7.645e-18	93.0	COG2881@1|root,COG2881@2|Bacteria,1N6EP@1224|Proteobacteria,42U9Y@68525|delta/epsilon subdivisions,2WQGR@28221|Deltaproteobacteria,2MAET@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	TIGRFAM MJ0042 family finger-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Yip1,zinc_ribbon_4
CMS2_k127_3696472_25	264732.Moth_0831	5.364e-87	304.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia,42IC3@68295|Thermoanaerobacterales	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_3696472_22	746697.Aeqsu_3165	2.388e-91	319.0	COG0793@1|root,COG0793@2|Bacteria,4NGGJ@976|Bacteroidetes,1HY6W@117743|Flavobacteriia	976|Bacteroidetes	M	peptidase S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
CMS2_k127_3696472_3	1291050.JAGE01000001_gene1446	3.075e-176	562.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,3WP0Y@541000|Ruminococcaceae	186801|Clostridia	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2,LuxC
CMS2_k127_3696472_31	60520.HR47_07540	1.191e-77	268.0	COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,4HAPT@91061|Bacilli,3F494@33958|Lactobacillaceae	91061|Bacilli	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
CMS2_k127_3696472_44	215803.DB30_2249	6.429e-51	190.0	COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,42MF3@68525|delta/epsilon subdivisions,2WJXS@28221|Deltaproteobacteria,2YVQQ@29|Myxococcales	28221|Deltaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
CMS2_k127_3696472_47	215803.DB30_1140	1.962e-49	183.0	COG4577@1|root,COG4577@2|Bacteria,1QG1Y@1224|Proteobacteria,42SEX@68525|delta/epsilon subdivisions,2WPTK@28221|Deltaproteobacteria,2YXHG@29|Myxococcales	28221|Deltaproteobacteria	CQ	BMC	-	-	-	-	-	-	-	-	-	-	-	-	BMC
CMS2_k127_3696472_24	215803.DB30_2258	3.314e-88	300.0	COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,42S16@68525|delta/epsilon subdivisions,2WNEY@28221|Deltaproteobacteria,2YUV2@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
CMS2_k127_3696472_69	215803.DB30_2248	1.425e-18	88.0	COG4576@1|root,COG4576@2|Bacteria,1Q8QH@1224|Proteobacteria,4354D@68525|delta/epsilon subdivisions,2WZFG@28221|Deltaproteobacteria,2Z20V@29|Myxococcales	28221|Deltaproteobacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	-	-	-	-	-	-	-	-	-	-	-	-	EutN_CcmL
CMS2_k127_3696472_74	1536772.R70723_28175	2.863e-17	85.0	COG4576@1|root,COG4576@2|Bacteria,1VEI4@1239|Firmicutes,4HNX2@91061|Bacilli,275ZG@186822|Paenibacillaceae	91061|Bacilli	CQ	Ethanolamine utilisation protein EutN/carboxysome	pduN	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
CMS2_k127_3696472_46	635013.TherJR_0632	3.44e-50	184.0	COG4577@1|root,COG4577@2|Bacteria,1UKDS@1239|Firmicutes,24IS5@186801|Clostridia,261TI@186807|Peptococcaceae	186801|Clostridia	CQ	Carbon dioxide concentrating mechanism carboxysome shell protein	csoS1C	-	-	-	-	-	-	-	-	-	-	-	BMC
CMS2_k127_3696472_13	913865.DOT_6139	7.154e-111	373.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,260FY@186807|Peptococcaceae	186801|Clostridia	C	PFAM Respiratory-chain NADH dehydrogenase 51 Kd subunit	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_17,RnfC_N,SLBB
CMS2_k127_3696472_7	502025.Hoch_5813	1.916e-145	476.0	COG1012@1|root,COG1012@2|Bacteria,1QUBI@1224|Proteobacteria,42P3A@68525|delta/epsilon subdivisions,2WIJU@28221|Deltaproteobacteria,2YYR4@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	-	-	-	ko:K04021	ko00620,ko01100,ko01120,map00620,map01100,map01120	-	R00228	RC00004,RC01195	ko00000,ko00001	-	-	-	Aldedh
CMS2_k127_3696472_58	215803.DB30_1142	1.813e-26	111.0	COG4576@1|root,COG4576@2|Bacteria,1RIK4@1224|Proteobacteria,4362N@68525|delta/epsilon subdivisions,2X9F2@28221|Deltaproteobacteria,2Z246@29|Myxococcales	28221|Deltaproteobacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	-	-	-	-	-	-	-	-	-	-	-	-	EutN_CcmL
CMS2_k127_3696472_51	215803.DB30_1141	1.877e-42	156.0	COG4577@1|root,COG4577@2|Bacteria,1RH1U@1224|Proteobacteria,42UCN@68525|delta/epsilon subdivisions,2WQ3V@28221|Deltaproteobacteria,2Z195@29|Myxococcales	28221|Deltaproteobacteria	CQ	BMC	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
CMS2_k127_3696472_73	357808.RoseRS_2140	1.401e-17	89.0	COG0457@1|root,COG0457@2|Bacteria,2G770@200795|Chloroflexi,374ST@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
CMS2_k127_3696472_80	521011.Mpal_1129	7.103e-12	75.0	COG0500@1|root,arCOG01783@2157|Archaea,2Y0HZ@28890|Euryarchaeota,2NABS@224756|Methanomicrobia	2157|Archaea	Q	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_3696472_19	237368.SCABRO_01644	4.355e-94	325.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Glycos_transf_2,Radical_SAM
CMS2_k127_3696472_6	743299.Acife_3019	3.486e-148	481.0	COG1232@1|root,COG1232@2|Bacteria,1P80H@1224|Proteobacteria,1S0R5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
CMS2_k127_3696472_68	1499967.BAYZ01000118_gene3243	4.265e-19	102.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	ko:K02847,ko:K13009	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	Wzy_C
CMS2_k127_3696472_85	1499967.BAYZ01000075_gene2073	2.464e-05	57.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	Wzy_C
CMS2_k127_3696472_59	1047013.AQSP01000115_gene360	6.885e-26	113.0	COG2165@1|root,COG2165@2|Bacteria,2NQ2Y@2323|unclassified Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS2_k127_3696472_15	857293.CAAU_1960	6.433e-106	359.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,36DTR@31979|Clostridiaceae	186801|Clostridia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
CMS2_k127_3696472_54	1379281.AVAG01000026_gene1610	1.113e-31	129.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2WPZQ@28221|Deltaproteobacteria,2MAU8@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
CMS2_k127_3696472_66	289376.THEYE_A0795	7.857e-20	92.0	COG0238@1|root,COG0238@2|Bacteria,3J1F7@40117|Nitrospirae	40117|Nitrospirae	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
CMS2_k127_3696472_63	485913.Krac_12484	9.378e-22	100.0	COG0360@1|root,COG0360@2|Bacteria,2G7DG@200795|Chloroflexi	200795|Chloroflexi	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
CMS2_k127_3696472_53	1047013.AQSP01000138_gene1003	1.299e-33	137.0	COG1825@1|root,COG1825@2|Bacteria,2NPVU@2323|unclassified Bacteria	2|Bacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
CMS2_k127_3696472_16	316067.Geob_1566	2.955e-105	351.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2WJ5W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2848	Pribosyl_synth,Pribosyltran_N
CMS2_k127_3696472_42	1047013.AQSP01000138_gene1001	1.207e-56	209.0	COG1947@1|root,COG1947@2|Bacteria,2NPGM@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	2.1.1.182,2.7.1.148	ko:K00919,ko:K02528,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096,M00582	R05634,R10716	RC00002,RC00003,RC01439,RC03257	ko00000,ko00001,ko00002,ko01000,ko02000,ko03009	3.A.1.29	-	iEC55989_1330.EC55989_1304,iLJ478.TM1383,iYO844.BSU00460	GHMP_kinases_C,GHMP_kinases_N
CMS2_k127_3696472_34	335543.Sfum_1732	4.111e-72	249.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2WNNG@28221|Deltaproteobacteria,2MRM5@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_3696472_49	518766.Rmar_2647	1.641e-48	181.0	COG0400@1|root,COG0400@2|Bacteria,4NHWT@976|Bacteroidetes,1FJF1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Serine hydrolase (FSH1)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,FSH1
CMS2_k127_3696472_1	526222.Desal_3328	2.848e-246	812.0	COG0642@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria,1NRP8@1224|Proteobacteria,42PU4@68525|delta/epsilon subdivisions,2WMBQ@28221|Deltaproteobacteria,2M8GC@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_3696472_57	1346330.M472_14605	1.047e-26	115.0	COG1576@1|root,COG1576@2|Bacteria,4NMFP@976|Bacteroidetes,1ISE3@117747|Sphingobacteriia	976|Bacteroidetes	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
CMS2_k127_3696671_1	272624.lpg1331	0.0003376	52.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1JCQU@118969|Legionellales	118969|Legionellales	M	Trypsin	degQ	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS2_k127_3708673_0	1453501.JELR01000001_gene2494	1.85e-80	291.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1T4K6@1236|Gammaproteobacteria,46DC0@72275|Alteromonadaceae	1236|Gammaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	ppkA	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase,PEGA,Pkinase
CMS2_k127_3716817_2	395493.BegalDRAFT_3545	2.296e-44	177.0	COG0500@1|root,COG0500@2|Bacteria,1QVKX@1224|Proteobacteria	1224|Proteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_3716817_0	1047013.AQSP01000135_gene1622	6.42e-63	224.0	COG1774@1|root,COG1774@2|Bacteria,2NPEB@2323|unclassified Bacteria	2|Bacteria	S	PSP1 C-terminal conserved region	yaaT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	PSP1
CMS2_k127_3716817_1	1047013.AQSP01000135_gene1621	4.556e-47	182.0	COG2812@1|root,COG2812@2|Bacteria,2NPH0@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
CMS2_k127_3731272_0	1122176.KB903576_gene5032	1.691e-165	550.0	COG2319@1|root,COG4995@1|root,COG2319@2|Bacteria,COG4995@2|Bacteria,4P49H@976|Bacteroidetes	976|Bacteroidetes	H	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
CMS2_k127_3731272_9	931626.Awo_c14400	1.614e-10	70.0	COG2374@1|root,COG2374@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Exo_endo_phos,LTD,PKD
CMS2_k127_3731272_2	123214.PERMA_0046	2.836e-85	298.0	COG1373@1|root,COG1373@2|Bacteria,2G4ED@200783|Aquificae	200783|Aquificae	S	AAA domain	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_3731272_8	1033732.CAHI01000030_gene1035	1.282e-10	70.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,2FWSR@200643|Bacteroidia	976|Bacteroidetes	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_3731272_1	1391647.AVSV01000003_gene1626	7.114e-152	503.0	COG0076@1|root,COG0076@2|Bacteria,1TSV0@1239|Firmicutes,25D2Z@186801|Clostridia,36U67@31979|Clostridiaceae	186801|Clostridia	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.25	ko:K22330	ko00350,map00350	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
CMS2_k127_3731272_4	219305.MCAG_00587	3.572e-20	107.0	COG1511@1|root,COG1511@2|Bacteria	2|Bacteria	Q	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF294,DUF294_C,GUN4,LysM,Tubulin_2
CMS2_k127_3731272_10	883081.HMPREF9698_00240	0.0002359	55.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,27FB8@186828|Carnobacteriaceae	91061|Bacilli	KLT	Protein tyrosine kinase	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_3731272_3	324602.Caur_3801	2.198e-24	115.0	COG0639@1|root,COG0639@2|Bacteria,2G6GC@200795|Chloroflexi,375HP@32061|Chloroflexia	32061|Chloroflexia	T	PFAM metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
CMS2_k127_3731272_5	65093.PCC7418_3847	1.741e-18	102.0	COG1511@1|root,COG1511@2|Bacteria,1G29D@1117|Cyanobacteria	1117|Cyanobacteria	L	Tubulin like	-	-	-	-	-	-	-	-	-	-	-	-	Tubulin_2
CMS2_k127_3731272_7	234267.Acid_6217	3.941e-12	80.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
CMS2_k127_3731272_6	509191.AEDB02000054_gene3661	1.565e-17	98.0	COG0860@1|root,COG2304@1|root,COG3103@1|root,COG3637@1|root,COG5297@1|root,COG0860@2|Bacteria,COG2304@2|Bacteria,COG3103@2|Bacteria,COG3637@2|Bacteria,COG5297@2|Bacteria,1V09B@1239|Firmicutes,25F6N@186801|Clostridia,3WS7V@541000|Ruminococcaceae	186801|Clostridia	M	Ig domain protein group 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,PT-TG,VWA
CMS2_k127_3772728_0	1117108.PAALTS15_12777	0.0	2246.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3772728_1	118005.AWNK01000004_gene1064	2.687e-116	396.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_378290_4	1121403.AUCV01000073_gene1307	1.834e-16	89.0	COG1345@1|root,COG3209@1|root,COG3485@1|root,COG4676@1|root,COG1345@2|Bacteria,COG3209@2|Bacteria,COG3485@2|Bacteria,COG4676@2|Bacteria,1R0C4@1224|Proteobacteria,43CUG@68525|delta/epsilon subdivisions,2X825@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	TIGRFAM RHS repeat-associated core domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_378290_2	573061.Clocel_3102	1.47e-65	245.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_378290_3	1313304.CALK_1903	5.184e-56	202.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS2_k127_378290_0	349520.PPE_02180	0.0	3587.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	fusAA	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_378290_1	1042163.BRLA_c026460	0.0	1206.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_31,PP-binding,Thioesterase
CMS2_k127_3786131_18	1122172.KB890271_gene294	5.769e-05	54.0	COG0790@1|root,COG0790@2|Bacteria	2|Bacteria	S	beta-lactamase activity	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1,TPR_2,TPR_8
CMS2_k127_3786131_15	1540257.JQMW01000009_gene3795	3.904e-17	92.0	COG0308@1|root,COG0308@2|Bacteria	2|Bacteria	E	peptide catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1,Peptidase_MA_2
CMS2_k127_3786131_4	484770.UFO1_3037	1.464e-81	287.0	COG0535@1|root,COG0535@2|Bacteria,1UYFI@1239|Firmicutes,4H3FR@909932|Negativicutes	909932|Negativicutes	C	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS2_k127_3786131_3	502025.Hoch_1667	4.423e-131	440.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_3786131_8	272123.Anacy_4919	1.568e-53	192.0	2FFE4@1|root,347BQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3786131_12	272123.Anacy_4920	7.16e-36	138.0	2A03C@1|root,30N5V@2|Bacteria,1GJWZ@1117|Cyanobacteria,1HSS1@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3786131_7	1144310.PMI07_005735	6.802e-58	218.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,2U8HJ@28211|Alphaproteobacteria,4BAA6@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	SMART Capsule synthesis protein, CapA	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
CMS2_k127_3786131_9	673860.AciM339_0128	4.308e-53	192.0	COG1528@1|root,arCOG01095@2157|Archaea,2XXEN@28890|Euryarchaeota,3F39S@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	Ferritin-like domain	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
CMS2_k127_3786131_13	706587.Desti_0293	4.346e-34	136.0	COG1633@1|root,COG1633@2|Bacteria,1N4PW@1224|Proteobacteria,42UZG@68525|delta/epsilon subdivisions,2WNGQ@28221|Deltaproteobacteria,2MS9U@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_3786131_6	391625.PPSIR1_36277	3.734e-58	231.0	COG0326@1|root,COG0326@2|Bacteria	2|Bacteria	O	unfolded protein binding	-	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c_3,Helicase_C,Peptidase_C14,ResIII
CMS2_k127_3786131_10	518766.Rmar_0215	1.165e-51	203.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,4NEKW@976|Bacteroidetes,1FIWV@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Transglycosylase SLT domain	mltD	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
CMS2_k127_3786131_11	1288494.EBAPG3_22480	2.702e-38	146.0	2EBPV@1|root,335PY@2|Bacteria,1NK03@1224|Proteobacteria,2VY2U@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1360
CMS2_k127_3786131_16	1288494.EBAPG3_22490	6.812e-13	72.0	28UGW@1|root,2ZGMQ@2|Bacteria,1PAJG@1224|Proteobacteria,2W686@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3786131_5	56780.SYN_00663	3.96e-77	262.0	COG1751@1|root,COG1751@2|Bacteria,1RBXI@1224|Proteobacteria,42R3D@68525|delta/epsilon subdivisions,2WMRV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
CMS2_k127_3786131_1	985255.APHJ01000026_gene2306	1.723e-235	747.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,1HZ0Y@117743|Flavobacteriia,2P7EZ@244698|Gillisia	976|Bacteroidetes	EU	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS2_k127_3786131_0	1168034.FH5T_05950	9.548e-290	910.0	COG2366@1|root,COG2366@2|Bacteria,4NEIX@976|Bacteroidetes	976|Bacteroidetes	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
CMS2_k127_3802501_1	1122176.KB903576_gene5032	1.303e-35	140.0	COG2319@1|root,COG4995@1|root,COG2319@2|Bacteria,COG4995@2|Bacteria,4P49H@976|Bacteroidetes	976|Bacteroidetes	H	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
CMS2_k127_3802501_0	1077285.AGDG01000012_gene3501	3.685e-141	468.0	COG1429@1|root,COG1429@2|Bacteria,4P0BG@976|Bacteroidetes,2FMJ7@200643|Bacteroidia,4AN00@815|Bacteroidaceae	976|Bacteroidetes	H	COG NOG08812 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,PDDEXK_9
CMS2_k127_3814451_2	580340.Tlie_0461	9.241e-221	696.0	COG1743@1|root,COG1743@2|Bacteria,3TCDM@508458|Synergistetes	508458|Synergistetes	L	DNA methylAse	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3814451_0	580340.Tlie_0463	0.0	1294.0	COG0553@1|root,COG0553@2|Bacteria,3T9Z9@508458|Synergistetes	508458|Synergistetes	L	PFAM helicase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3883,Helicase_C,SNF2_N
CMS2_k127_3814451_9	1499967.BAYZ01000194_gene3125	8.497e-46	168.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
CMS2_k127_3814451_3	880073.Calab_3390	1.061e-191	602.0	COG1740@1|root,COG1740@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor	hyaA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0048037,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_76,iUTI89_1310.UTI89_C1040	NiFe_hyd_SSU_C,Oxidored_q6
CMS2_k127_3814451_1	880073.Calab_3389	1.482e-316	974.0	COG0374@1|root,COG0374@2|Bacteria	2|Bacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hyaB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016151,GO:0016491,GO:0022900,GO:0030288,GO:0030313,GO:0031975,GO:0032991,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0044569,GO:0045333,GO:0046872,GO:0046914,GO:0055114,GO:0071944,GO:1902494	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	iSbBS512_1146.SbBS512_E2342	NiFeSe_Hases
CMS2_k127_3814451_5	880073.Calab_3388	1.712e-109	360.0	COG1969@1|root,COG1969@2|Bacteria	2|Bacteria	C	respiratory electron transport chain	cybH	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0020037,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
CMS2_k127_3814451_10	880073.Calab_3387	1.642e-45	169.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	hydD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
CMS2_k127_3814451_11	555779.Dthio_PD1992	4.313e-45	166.0	COG3742@1|root,COG3742@2|Bacteria,1Q9V8@1224|Proteobacteria,432KI@68525|delta/epsilon subdivisions,2WXAS@28221|Deltaproteobacteria,2MFTK@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_3814451_14	555779.Dthio_PD1991	1.051e-21	96.0	COG4423@1|root,COG4423@2|Bacteria,1NDG1@1224|Proteobacteria	1224|Proteobacteria	S	Transcription factor	-	-	-	ko:K19687	-	-	-	-	ko00000,ko02048	-	-	-	PSK_trans_fac
CMS2_k127_3814451_16	324925.Ppha_0682	2.453e-18	87.0	COG2161@1|root,COG2161@2|Bacteria	2|Bacteria	D	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
CMS2_k127_3814451_13	1226325.HMPREF1548_01130	6.306e-25	119.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,36F1U@31979|Clostridiaceae	186801|Clostridia	C	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
CMS2_k127_3814451_12	573370.DMR_39880	5.868e-31	126.0	COG3744@1|root,COG3744@2|Bacteria,1N2T0@1224|Proteobacteria,436GN@68525|delta/epsilon subdivisions,2X12Q@28221|Deltaproteobacteria,2ME34@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_3814451_15	760142.Hipma_0060	1.755e-19	93.0	COG0593@1|root,COG1943@1|root,COG0593@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42RDM@68525|delta/epsilon subdivisions,2WMYM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Chromosomal replication initiator, DnaA	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Bac_DnaA_C,Y1_Tnp
CMS2_k127_3814451_8	1173022.Cri9333_4294	4.429e-48	188.0	COG1216@1|root,COG1216@2|Bacteria,1G3T8@1117|Cyanobacteria,1HA4H@1150|Oscillatoriales	1117|Cyanobacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
CMS2_k127_3814451_7	926556.Echvi_2965	1.422e-88	304.0	COG1817@1|root,COG1817@2|Bacteria,4NMZC@976|Bacteroidetes,47T62@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
CMS2_k127_3814451_17	177437.HRM2_25510	2.21e-14	79.0	COG0681@1|root,COG0681@2|Bacteria	2|Bacteria	U	signal peptide processing	trhF	-	3.4.21.89	ko:K03100,ko:K12062,ko:K13280	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02044	3.A.7.11.1	-	-	Peptidase_S24,Peptidase_S26
CMS2_k127_3814451_6	1047013.AQSP01000036_gene1385	6.612e-94	336.0	COG4796@1|root,COG4796@2|Bacteria	2|Bacteria	U	Type ii and iii secretion system protein	pulQ	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Cohesin,STN,Secretin,Secretin_N
CMS2_k127_3814451_4	1499967.BAYZ01000100_gene3454	2.888e-124	408.0	2EVWS@1|root,33PAF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_381945_4	1047013.AQSP01000061_gene1216	1.066e-14	83.0	COG3408@1|root,COG3408@2|Bacteria,2NPYR@2323|unclassified Bacteria	2|Bacteria	G	Amylo-alpha-1,6-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
CMS2_k127_381945_0	1047013.AQSP01000073_gene1095	2.084e-214	689.0	COG3408@1|root,COG3408@2|Bacteria,2NPVQ@2323|unclassified Bacteria	2|Bacteria	G	Trehalase	-	-	-	ko:K03931	-	-	-	-	ko00000	-	GH63	-	Glyco_hydro_63,Trehalase
CMS2_k127_381945_1	56780.SYN_01257	5.781e-86	297.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2WJC3@28221|Deltaproteobacteria,2MQ77@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Bacterial transferase hexapeptide (six repeats)	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
CMS2_k127_381945_3	521098.Aaci_2197	4.144e-24	102.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli	91061|Bacilli	K	Cold-Shock Protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CMS2_k127_381945_2	1511.CLOST_1306	6.256e-61	214.0	COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,25RA2@186804|Peptostreptococcaceae	186801|Clostridia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
CMS2_k127_3824807_0	177437.HRM2_34080	2.808e-104	378.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,1N26H@1224|Proteobacteria,43EV4@68525|delta/epsilon subdivisions,2WR4K@28221|Deltaproteobacteria,2MNP4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS2_k127_3824807_1	272134.KB731324_gene3323	1.463e-81	287.0	COG1192@1|root,COG1192@2|Bacteria,1GQ7V@1117|Cyanobacteria	1117|Cyanobacteria	D	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
CMS2_k127_38425_2	755731.Clo1100_0890	0.0	1886.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_38425_4	1196323.ALKF01000205_gene4116	0.0	1421.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_38425_6	1117108.PAALTS15_22593	5.695e-292	934.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	pksM3	-	-	ko:K13611,ko:K13614,ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01004,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_38425_8	509191.AEDB02000067_gene917	2.813e-226	732.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WNP0@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_38425_10	509191.AEDB02000067_gene918	3.772e-157	513.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_38425_3	1121121.KB894288_gene2765	0.0	1743.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_38425_11	391587.KAOT1_11442	4.27e-110	382.0	2A0ZJ@1|root,30P4V@2|Bacteria,4P1YK@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_38425_7	391587.KAOT1_11447	1.49e-236	745.0	COG2192@1|root,COG2192@2|Bacteria,4NEV9@976|Bacteroidetes,1HZ9A@117743|Flavobacteriia	976|Bacteroidetes	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS2_k127_38425_12	391587.KAOT1_11442	4.3e-106	371.0	2A0ZJ@1|root,30P4V@2|Bacteria,4P1YK@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_38425_0	1087481.AGFX01000046_gene2041	0.0	2116.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_38425_1	1042163.BRLA_c025650	0.0	2059.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15662	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_38425_9	509191.AEDB02000067_gene916	3.179e-183	589.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_38425_5	1501230.ET33_19185	0.0	1374.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3858802_4	1211115.ALIQ01000218_gene1483	2.808e-11	64.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2TTN2@28211|Alphaproteobacteria,3N9X6@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	urtC	-	-	ko:K11961	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
CMS2_k127_3858802_0	765913.ThidrDRAFT_2218	8.69e-116	379.0	COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,1RM8F@1236|Gammaproteobacteria,1WXAW@135613|Chromatiales	135613|Chromatiales	S	pfam abc	-	-	-	ko:K11962	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran,BCA_ABC_TP_C
CMS2_k127_3858802_1	1283284.AZUK01000002_gene2904	1.381e-103	342.0	COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,1RMEM@1236|Gammaproteobacteria,1Y6GG@135624|Aeromonadales	135624|Aeromonadales	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K11963	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
CMS2_k127_3858802_3	1123401.JHYQ01000013_gene615	8.836e-16	79.0	COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,1SCH1@1236|Gammaproteobacteria,461BQ@72273|Thiotrichales	72273|Thiotrichales	S	Membrane fusogenic activity	-	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
CMS2_k127_3858802_2	1208321.D104_05500	9.8e-58	202.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1XJH4@135619|Oceanospirillales	135619|Oceanospirillales	K	at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA)	glnK-2	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
CMS2_k127_3859090_4	1121405.dsmv_1634	1.853e-12	66.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,42W2F@68525|delta/epsilon subdivisions,2WRUM@28221|Deltaproteobacteria,2MKSW@213118|Desulfobacterales	28221|Deltaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	ihfA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS2_k127_3859090_1	439235.Dalk_2464	1.13e-26	111.0	2EAYI@1|root,334ZG@2|Bacteria,1N8W1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3859090_0	177437.HRM2_19070	7.383e-61	216.0	COG0582@1|root,COG0582@2|Bacteria,1MVZB@1224|Proteobacteria,42T3Q@68525|delta/epsilon subdivisions,2WPUB@28221|Deltaproteobacteria,2MKDP@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K14059	-	-	-	-	ko00000	-	-	-	Phage_int_SAM_3,Phage_integrase
CMS2_k127_3859090_3	311424.DhcVS_1333	3.389e-23	100.0	COG2801@1|root,COG2801@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia	301297|Dehalococcoidia	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
CMS2_k127_3859090_2	1121440.AUMA01000006_gene1719	1.27e-23	102.0	COG1961@1|root,COG1961@2|Bacteria,1RIV6@1224|Proteobacteria,42UK1@68525|delta/epsilon subdivisions,2WQXV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Resolvase
CMS2_k127_3893108_21	439235.Dalk_1464	2.256e-08	58.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales	1224|Proteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
CMS2_k127_3893108_2	706587.Desti_2378	3.417e-190	624.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	formate C-acetyltransferase glycine radical	-	-	-	-	-	-	-	-	-	-	-	-	Gly_radical,PFL-like
CMS2_k127_3893108_8	706587.Desti_2376	6.89e-61	221.0	COG1180@1|root,COG1180@2|Bacteria,1QJHU@1224|Proteobacteria,42R2E@68525|delta/epsilon subdivisions,2WMYN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM glycyl-radical enzyme activating protein family	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS2_k127_3893108_4	1469245.JFBG01000053_gene2088	4.587e-134	439.0	COG4637@1|root,COG4637@2|Bacteria,1R7PU@1224|Proteobacteria,1RQJE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21
CMS2_k127_3893108_13	379066.GAU_3713	6.658e-30	121.0	COG2944@1|root,COG2944@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	Fer4,HTH_3,HTH_31
CMS2_k127_3893108_16	1003200.AXXA_02033	4.943e-19	88.0	COG4737@1|root,COG4737@2|Bacteria,1N7N5@1224|Proteobacteria,2VXKF@28216|Betaproteobacteria,3T4JG@506|Alcaligenaceae	28216|Betaproteobacteria	S	RelE toxin of RelE / RelB toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	RelE
CMS2_k127_3893108_9	221288.JH992901_gene5599	5.358e-56	218.0	COG1672@1|root,COG1672@2|Bacteria,1G0F4@1117|Cyanobacteria,1JK6Z@1189|Stigonemataceae	1117|Cyanobacteria	S	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35,CHAT
CMS2_k127_3893108_20	85681.XP_006432596.1	2.48e-11	77.0	KOG4658@1|root,KOG4658@2759|Eukaryota,37RFN@33090|Viridiplantae,3GH54@35493|Streptophyta	35493|Streptophyta	T	Disease resistance protein	-	-	-	ko:K13459	ko04626,map04626	-	-	-	ko00000,ko00001	-	-	-	NB-ARC
CMS2_k127_3893108_18	8364.ENSXETP00000011433	7.157e-16	91.0	KOG1130@1|root,KOG1130@2759|Eukaryota,38BEC@33154|Opisthokonta,3BBV7@33208|Metazoa,3CSNR@33213|Bilateria,483EY@7711|Chordata,490RF@7742|Vertebrata	33208|Metazoa	T	Ran protein signal transduction	GPSM2	GO:0000132,GO:0000226,GO:0000278,GO:0000922,GO:0001709,GO:0001965,GO:0003674,GO:0005092,GO:0005096,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005813,GO:0005815,GO:0005819,GO:0005829,GO:0005856,GO:0005938,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007051,GO:0007052,GO:0007154,GO:0007163,GO:0007165,GO:0007186,GO:0007264,GO:0007265,GO:0007275,GO:0007346,GO:0007399,GO:0007400,GO:0007405,GO:0008022,GO:0008047,GO:0008104,GO:0008150,GO:0008283,GO:0008356,GO:0009987,GO:0010564,GO:0010638,GO:0014016,GO:0014017,GO:0015630,GO:0016020,GO:0016043,GO:0017145,GO:0019904,GO:0022008,GO:0022402,GO:0023052,GO:0030010,GO:0030154,GO:0030234,GO:0030695,GO:0031291,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0032886,GO:0032991,GO:0033036,GO:0033043,GO:0035556,GO:0036445,GO:0040001,GO:0042802,GO:0043085,GO:0043087,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043547,GO:0043621,GO:0044087,GO:0044089,GO:0044093,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044448,GO:0044464,GO:0044877,GO:0045165,GO:0045167,GO:0045175,GO:0045177,GO:0045179,GO:0045185,GO:0045787,GO:0048103,GO:0048518,GO:0048522,GO:0048699,GO:0048731,GO:0048856,GO:0048863,GO:0048865,GO:0048867,GO:0048869,GO:0050789,GO:0050790,GO:0050794,GO:0050795,GO:0050896,GO:0051128,GO:0051130,GO:0051179,GO:0051234,GO:0051235,GO:0051293,GO:0051294,GO:0051301,GO:0051336,GO:0051345,GO:0051493,GO:0051495,GO:0051640,GO:0051641,GO:0051642,GO:0051649,GO:0051651,GO:0051653,GO:0051656,GO:0051657,GO:0051661,GO:0051716,GO:0051726,GO:0055057,GO:0055059,GO:0060236,GO:0060259,GO:0060341,GO:0060589,GO:0061351,GO:0061842,GO:0065007,GO:0065008,GO:0065009,GO:0070507,GO:0070840,GO:0071840,GO:0071944,GO:0072089,GO:0072686,GO:0090068,GO:0090169,GO:0090224,GO:0097431,GO:0097574,GO:0097575,GO:0098722,GO:0098772,GO:0099568,GO:0099738,GO:1902115,GO:1902117,GO:1902850,GO:1903047,GO:1903827,GO:1903829,GO:1904375,GO:1904377,GO:1904776,GO:1904778,GO:1905832	-	ko:K15837,ko:K15839	ko05030,map05030	-	-	-	ko00000,ko00001,ko03036	-	-	-	GoLoco,TPR_12,TPR_7
CMS2_k127_3893108_5	485915.Dret_2367	3.316e-122	407.0	COG1373@1|root,COG1373@2|Bacteria,1MWDX@1224|Proteobacteria,4302U@68525|delta/epsilon subdivisions,2WVDX@28221|Deltaproteobacteria,2MF0W@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_3893108_12	760192.Halhy_4926	2.933e-39	153.0	28YPV@1|root,2ZKHE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3893108_6	760192.Halhy_4927	1.382e-120	396.0	COG0451@1|root,COG0451@2|Bacteria,4NEMN@976|Bacteroidetes,1IQN9@117747|Sphingobacteriia	976|Bacteroidetes	M	PFAM NAD dependent epimerase dehydratase family	dfrA	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
CMS2_k127_3893108_1	760192.Halhy_4928	4.853e-193	627.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS2_k127_3893108_3	760192.Halhy_4928	3.193e-181	595.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS2_k127_3893108_24	266748.HY04_07245	2.573e-05	54.0	2FJ92@1|root,34AZ4@2|Bacteria,4P6KM@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3893108_10	641491.DND132_2129	4.022e-55	202.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,42R8W@68525|delta/epsilon subdivisions,2WMZU@28221|Deltaproteobacteria,2M8M3@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
CMS2_k127_3893108_7	177437.HRM2_41610	1.557e-74	253.0	COG1839@1|root,COG1839@2|Bacteria,1RBCB@1224|Proteobacteria,42S44@68525|delta/epsilon subdivisions,2WMAS@28221|Deltaproteobacteria,2MI4F@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
CMS2_k127_3893108_23	521460.Athe_1364	8.955e-06	59.0	COG2304@1|root,COG2304@2|Bacteria,1V5MY@1239|Firmicutes,25BP9@186801|Clostridia	186801|Clostridia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
CMS2_k127_3893108_0	1047013.AQSP01000142_gene185	0.0	1132.0	COG4447@1|root,COG4447@2|Bacteria,2NQ6W@2323|unclassified Bacteria	2|Bacteria	S	Por secretion system C-terminal sorting domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
CMS2_k127_3893108_14	646529.Desaci_3048	8.179e-21	99.0	COG1725@1|root,COG1725@2|Bacteria,1VA2B@1239|Firmicutes,24N57@186801|Clostridia,26324@186807|Peptococcaceae	186801|Clostridia	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS2_k127_3893108_15	435838.HMPREF0786_00402	8.261e-21	102.0	COG1131@1|root,COG1131@2|Bacteria,1UZ04@1239|Firmicutes,4HDGQ@91061|Bacilli,4GYIE@90964|Staphylococcaceae	91061|Bacilli	V	ABC transporter, ATP-binding protein	XK27_09825	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_3897415_0	316067.Geob_2141	1.137e-155	499.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,42MFI@68525|delta/epsilon subdivisions,2WKXD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_389762_0	225849.swp_0274	1.131e-79	274.0	2910Q@1|root,2ZNNC@2|Bacteria,1PCP3@1224|Proteobacteria,1S0BX@1236|Gammaproteobacteria,2Q953@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_389762_2	452637.Oter_0800	9.686e-18	92.0	COG0705@1|root,COG0705@2|Bacteria	2|Bacteria	S	proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS2_k127_389762_1	1304874.JAFY01000001_gene2615	3.271e-19	100.0	COG1470@1|root,COG3210@1|root,COG1470@2|Bacteria,COG3210@2|Bacteria,3TB3U@508458|Synergistetes	508458|Synergistetes	U	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_3908205_5	177437.HRM2_02020	3.822e-18	86.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42PUP@68525|delta/epsilon subdivisions,2WMAH@28221|Deltaproteobacteria,2MN7Y@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS2_k127_3908205_3	926550.CLDAP_08610	1.177e-32	128.0	2A50H@1|root,30TNP@2|Bacteria,2G96I@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
CMS2_k127_3908205_4	1121448.DGI_3015	1.472e-21	108.0	COG2006@1|root,COG2006@2|Bacteria,1N7GG@1224|Proteobacteria,42VMY@68525|delta/epsilon subdivisions,2WRZG@28221|Deltaproteobacteria,2M964@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS2_k127_3908205_0	1047013.AQSP01000067_gene2200	1.532e-190	617.0	COG3379@1|root,COG3379@2|Bacteria,2NQA7@2323|unclassified Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
CMS2_k127_3908205_1	1047013.AQSP01000067_gene2201	2.4e-165	542.0	COG3379@1|root,COG3379@2|Bacteria,2NQIG@2323|unclassified Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
CMS2_k127_3908205_6	1123242.JH636434_gene4158	1.166e-10	72.0	2DZX2@1|root,32VM6@2|Bacteria,2J2WS@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3908205_7	641107.CDLVIII_5635	1.348e-08	57.0	COG4637@1|root,COG4637@2|Bacteria,1TQ9X@1239|Firmicutes,247NI@186801|Clostridia,36E5J@31979|Clostridiaceae	186801|Clostridia	K	An automated process has identified a potential problem with this gene model	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,HTH_3,PDDEXK_9
CMS2_k127_3908205_2	1041930.Mtc_1988	6.994e-50	190.0	COG1813@1|root,COG2856@1|root,arCOG01863@2157|Archaea,arCOG07475@2157|Archaea,2Y0TB@28890|Euryarchaeota	28890|Euryarchaeota	K	IrrE N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M78
CMS2_k127_3925824_30	459349.CLOAM0971	4.289e-58	213.0	COG0178@1|root,COG0178@2|Bacteria,2NNT3@2323|unclassified Bacteria	2|Bacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS2_k127_3925824_49	622312.ROSEINA2194_03117	4.773e-13	81.0	COG0745@1|root,COG0745@2|Bacteria,1TSWT@1239|Firmicutes,248B6@186801|Clostridia	186801|Clostridia	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_3925824_43	933262.AXAM01000011_gene1796	2.173e-20	92.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	DUF2281,PhdYeFM_antitox
CMS2_k127_3925824_53	383372.Rcas_3687	0.0001944	45.0	COG3744@1|root,COG3744@2|Bacteria,2G9CV@200795|Chloroflexi,377FA@32061|Chloroflexia	32061|Chloroflexia	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_3925824_28	880073.Calab_1194	2.265e-64	236.0	COG0845@1|root,COG0845@2|Bacteria,2NR7K@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
CMS2_k127_3925824_1	880073.Calab_1195	0.0	1063.0	COG0841@1|root,COG0841@2|Bacteria,2NQI6@2323|unclassified Bacteria	2|Bacteria	V	AcrB/AcrD/AcrF family	mdtB	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS2_k127_3925824_3	880073.Calab_1196	5.386e-259	832.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS2_k127_3925824_19	690850.Desaf_3380	5.899e-91	312.0	COG0500@1|root,COG0500@2|Bacteria,1QW86@1224|Proteobacteria,42N1Q@68525|delta/epsilon subdivisions,2WJJS@28221|Deltaproteobacteria,2MA1B@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	O-methyltransferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
CMS2_k127_3925824_39	411469.EUBHAL_00990	2.026e-31	133.0	COG1583@1|root,COG1583@2|Bacteria,1VC7U@1239|Firmicutes,24CJS@186801|Clostridia,25YIH@186806|Eubacteriaceae	186801|Clostridia	L	CRISPR associated protein Cas6	cas6	-	-	ko:K19091	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas6
CMS2_k127_3925824_0	1158338.JNLJ01000001_gene325	0.0	1144.0	COG1048@1|root,COG1048@2|Bacteria,2G3S7@200783|Aquificae	200783|Aquificae	C	TIGRFAM aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
CMS2_k127_3925824_11	502025.Hoch_6665	2.947e-146	479.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2YXKT@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_3925824_13	502025.Hoch_6664	5.011e-124	411.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,433Y1@68525|delta/epsilon subdivisions,2X41I@28221|Deltaproteobacteria,2YXYJ@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_3925824_32	1235803.C825_00127	3.016e-46	183.0	COG1232@1|root,COG1232@2|Bacteria,4NJNP@976|Bacteroidetes,2G385@200643|Bacteroidia	976|Bacteroidetes	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
CMS2_k127_3925824_21	1499967.BAYZ01000147_gene695	8.766e-81	280.0	COG0472@1|root,COG0472@2|Bacteria	2|Bacteria	M	phospho-N-acetylmuramoyl-pentapeptide-transferase activity	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	CoA_binding_3,Glycos_transf_4
CMS2_k127_3925824_34	545697.HMPREF0216_00190	6.35e-44	172.0	COG1216@1|root,COG1216@2|Bacteria,1TSTE@1239|Firmicutes,249WH@186801|Clostridia,36E4U@31979|Clostridiaceae	186801|Clostridia	M	glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
CMS2_k127_3925824_10	1047013.AQSP01000140_gene2526	1.314e-161	518.0	COG0156@1|root,COG0156@2|Bacteria,2NNMX@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_3925824_47	1131269.AQVV01000029_gene54	1.548e-13	81.0	COG3980@1|root,COG3980@2|Bacteria	2|Bacteria	M	transferase activity, transferring hexosyl groups	spsG	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_3,Glyco_tran_28_C
CMS2_k127_3925824_6	580340.Tlie_1910	2.156e-220	687.0	COG4992@1|root,COG4992@2|Bacteria,3TAN5@508458|Synergistetes	508458|Synergistetes	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
CMS2_k127_3925824_9	580340.Tlie_0145	1.029e-161	520.0	COG3844@1|root,COG3844@2|Bacteria,3TA91@508458|Synergistetes	508458|Synergistetes	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
CMS2_k127_3925824_38	313606.M23134_01440	2.71e-33	136.0	COG2318@1|root,COG2318@2|Bacteria,4NRSP@976|Bacteroidetes,47QQ6@768503|Cytophagia	976|Bacteroidetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
CMS2_k127_3925824_26	309798.COPRO5265_1577	4.537e-67	236.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15,2.7.13.3	ko:K03564,ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	AhpC-TSA
CMS2_k127_3925824_23	880071.Fleli_2431	3.783e-78	280.0	COG1816@1|root,COG1816@2|Bacteria,4NG5W@976|Bacteroidetes,47TPF@768503|Cytophagia	976|Bacteroidetes	F	Adenosine/AMP deaminase	add	-	3.5.4.4	ko:K01488,ko:K19572	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
CMS2_k127_3925824_25	572544.Ilyop_0601	5.011e-71	243.0	COG2096@1|root,COG2096@2|Bacteria,379IZ@32066|Fusobacteria	32066|Fusobacteria	S	Psort location Cytoplasmic, score	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
CMS2_k127_3925824_2	765869.BDW_06165	1.321e-265	833.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2MSXD@213481|Bdellovibrionales,2WIT6@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
CMS2_k127_3925824_4	1047013.AQSP01000070_gene34	2.152e-250	823.0	COG3292@1|root,COG3920@1|root,COG3292@2|Bacteria,COG3920@2|Bacteria,2NNZT@2323|unclassified Bacteria	2|Bacteria	T	Two component regulator propeller	pdtaS	-	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,Reg_prop,Y_Y_Y
CMS2_k127_3925824_14	945713.IALB_0204	9.415e-105	351.0	COG1355@1|root,COG1355@2|Bacteria	2|Bacteria	C	regulation of microtubule-based process	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
CMS2_k127_3925824_8	1123376.AUIU01000011_gene862	7.429e-173	567.0	COG0443@1|root,COG0443@2|Bacteria,3J0D2@40117|Nitrospirae	40117|Nitrospirae	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
CMS2_k127_3925824_5	1047013.AQSP01000122_gene2251	1.787e-239	757.0	COG0465@1|root,COG0465@2|Bacteria,2NNQ5@2323|unclassified Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CMS2_k127_3925824_31	648996.Theam_0892	9.379e-49	183.0	COG1624@1|root,COG1624@2|Bacteria,2G3ZW@200783|Aquificae	200783|Aquificae	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
CMS2_k127_3925824_50	1379281.AVAG01000024_gene1876	4.975e-12	75.0	COG4856@1|root,COG4856@2|Bacteria,1REEU@1224|Proteobacteria,42RY2@68525|delta/epsilon subdivisions,2WNZH@28221|Deltaproteobacteria,2MC38@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM YbbR family protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
CMS2_k127_3925824_17	287.DR97_2093	1.411e-96	332.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1YFGX@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS2_k127_3925824_24	1158318.ATXC01000001_gene465	9.827e-78	266.0	COG0854@1|root,COG0854@2|Bacteria,2G3M8@200783|Aquificae	200783|Aquificae	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
CMS2_k127_3925824_35	1047013.AQSP01000083_gene1193	2.605e-38	166.0	COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria	2|Bacteria	E	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,PD40,Peptidase_M1
CMS2_k127_3925824_52	430498.S8BIV2	0.0001357	50.0	2E46X@1|root,2SB54@2759|Eukaryota,3A86X@33154|Opisthokonta,3P797@4751|Fungi,3R0MW@4890|Ascomycota	4751|Fungi	S	fungal protein	-	GO:0005575,GO:0005623,GO:0009986,GO:0044464	-	-	-	-	-	-	-	-	-	-	GPI-anchored
CMS2_k127_3925824_51	41431.PCC8801_1300	1.793e-08	66.0	COG0457@1|root,COG0457@2|Bacteria,1GIT8@1117|Cyanobacteria,3KHZU@43988|Cyanothece	1117|Cyanobacteria	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_2,TPR_8,Trypsin_2
CMS2_k127_3925824_36	1047013.AQSP01000088_gene1630	6.6e-38	150.0	COG0457@1|root,COG0457@2|Bacteria	1047013.AQSP01000088_gene1630|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3925824_18	1047013.AQSP01000134_gene1352	3.477e-91	317.0	COG4690@1|root,COG4690@2|Bacteria	2|Bacteria	E	dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
CMS2_k127_3925824_42	1395513.P343_00530	1.435e-21	100.0	COG0454@1|root,COG0456@2|Bacteria,1V4GU@1239|Firmicutes,4HKA1@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_3925824_7	1499967.BAYZ01000083_gene1031	3.052e-218	690.0	COG1022@1|root,COG1022@2|Bacteria,2NQQS@2323|unclassified Bacteria	2|Bacteria	I	AMP-binding enzyme	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
CMS2_k127_3925824_16	1499967.BAYZ01000017_gene6221	1.126e-96	332.0	COG2148@1|root,COG2148@2|Bacteria,2NP0Q@2323|unclassified Bacteria	2|Bacteria	M	Bacterial sugar transferase	wcaJ	-	-	ko:K03606	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,CoA_binding_3
CMS2_k127_3925824_15	1379698.RBG1_1C00001G1896	1.851e-98	332.0	COG0438@1|root,COG0438@2|Bacteria,2NP1P@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase Family 4	wcnD	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_3925824_44	1047013.AQSP01000132_gene1736	8.116e-19	101.0	28WP9@1|root,2ZINZ@2|Bacteria	1047013.AQSP01000132_gene1736|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3925824_41	880073.Calab_1220	5.703e-23	109.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	tonB3	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2,TonB_C
CMS2_k127_3925824_29	880073.Calab_1219	6.358e-62	220.0	COG0811@1|root,COG0811@2|Bacteria,2NPFR@2323|unclassified Bacteria	2|Bacteria	U	MotA/TolQ/ExbB proton channel family	exbB2	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
CMS2_k127_3925824_40	880073.Calab_1218	3.992e-29	120.0	COG0848@1|root,COG0848@2|Bacteria,2NQ52@2323|unclassified Bacteria	2|Bacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
CMS2_k127_3925824_22	313612.L8106_08606	8.015e-79	282.0	COG0578@1|root,COG0578@2|Bacteria,1G1T3@1117|Cyanobacteria,1H86N@1150|Oscillatoriales	1117|Cyanobacteria	C	FAD dependent oxidoreductase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
CMS2_k127_3925824_27	754476.Q7A_2577	8.162e-66	237.0	COG2199@1|root,COG3706@2|Bacteria,1R6GI@1224|Proteobacteria,1T1KI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	(GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS2_k127_3925824_20	1121403.AUCV01000007_gene1230	3.629e-90	313.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2MHS5@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS2_k127_3925824_12	56780.SYN_02213	1.187e-135	470.0	COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1R891@1224|Proteobacteria,42P2C@68525|delta/epsilon subdivisions,2WJZT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
CMS2_k127_3925824_33	857293.CAAU_0539	1.98e-44	173.0	COG1619@1|root,COG1619@2|Bacteria,1TRBB@1239|Firmicutes,24ABA@186801|Clostridia,36EBC@31979|Clostridiaceae	186801|Clostridia	V	PFAM peptidase U61, LD-carboxypeptidase A	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
CMS2_k127_3925824_37	1047013.AQSP01000129_gene284	1.662e-37	164.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	zraS_1	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS2_k127_3925824_48	1511.CLOST_1306	1.549e-13	70.0	COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,25RA2@186804|Peptostreptococcaceae	186801|Clostridia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
CMS2_k127_3929818_6	1047013.AQSP01000132_gene1742	4.248e-09	68.0	COG3391@1|root,COG3391@2|Bacteria,2NQ4G@2323|unclassified Bacteria	2|Bacteria	O	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,NHL,TolB_like
CMS2_k127_3929818_1	1174528.JH992893_gene6024	0.0	1433.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_3929818_0	1408422.JHYF01000017_gene1871	0.0	2127.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3929818_7	247490.KSU1_D0030	0.0001037	48.0	COG3945@1|root,COG3945@2|Bacteria,2J2KE@203682|Planctomycetes	203682|Planctomycetes	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
CMS2_k127_3929818_4	509191.AEDB02000067_gene916	2.971e-149	491.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_3929818_5	574375.BAGA_05180	7.212e-77	296.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3929818_2	394503.Ccel_2386	9.194e-274	915.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_3929818_3	720555.BATR1942_07350	1.427e-208	679.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	ko:K15662,ko:K15663	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_3945501_1	509191.AEDB02000022_gene2935	1.127e-117	412.0	COG2006@1|root,COG2006@2|Bacteria,1VRZ8@1239|Firmicutes,24Z9V@186801|Clostridia,3WN5G@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Dockerin_1
CMS2_k127_3945501_2	439235.Dalk_0237	6.16e-106	377.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_3945501_0	1444711.CCJF01000005_gene546	2.069e-149	507.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta,SBBP
CMS2_k127_3945501_3	1250232.JQNJ01000001_gene1018	1.089e-22	115.0	COG3656@1|root,COG4886@1|root,COG3656@2|Bacteria,COG4886@2|Bacteria,4NR6Y@976|Bacteroidetes,1I2WF@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM Receptor L domain	-	-	-	-	-	-	-	-	-	-	-	-	ASH
CMS2_k127_397201_0	1408422.JHYF01000001_gene2874	5.233e-176	568.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654,ko:K15664	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3981178_0	449447.MAE_60010	0.0	2410.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria	1117|Cyanobacteria	Q	Amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_25,PP-binding,Thioesterase
CMS2_k127_3981178_2	1200792.AKYF01000017_gene5571	0.0	1237.0	COG0331@1|root,COG2070@1|root,COG3321@1|root,COG0331@2|Bacteria,COG2070@2|Bacteria,COG3321@2|Bacteria,1UG0E@1239|Firmicutes,4HTY4@91061|Bacilli,274JP@186822|Paenibacillaceae	91061|Bacilli	IQ	Acyl transferase domain	-	-	-	ko:K15329	-	-	-	-	ko00000,ko01008	-	-	-	Acyl_transf_1
CMS2_k127_3981178_1	485913.Krac_6972	0.0	1469.0	COG1020@1|root,COG1020@2|Bacteria,2G86H@200795|Chloroflexi	2|Bacteria	Q	PFAM AMP-dependent synthetase and ligase	pvdI	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase,WES_acyltransf
CMS2_k127_3988145_1	394503.Ccel_2381	7.965e-129	435.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_31,PP-binding,ketoacyl-synt
CMS2_k127_3988145_2	1500893.JQNB01000001_gene2620	7.792e-60	224.0	COG2308@1|root,COG2308@2|Bacteria	2|Bacteria	S	glutamate-cysteine ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2,GSP_synth
CMS2_k127_3988145_0	573061.Clocel_2487	1.615e-221	722.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3988952_0	1009370.ALO_00935	0.0	1373.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_3989003_0	1501230.ET33_19185	0.0	1148.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_3995629_1	1499967.BAYZ01000164_gene6655	3.087e-34	135.0	COG2204@1|root,COG2204@2|Bacteria,2NRGX@2323|unclassified Bacteria	2|Bacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HisKA,PAS_3,Response_reg
CMS2_k127_3995629_0	933262.AXAM01000017_gene3111	5.124e-103	346.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MJ29@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_3
CMS2_k127_4019606_0	880072.Desac_2826	7.039e-119	398.0	COG3746@1|root,COG3746@2|Bacteria,1RA39@1224|Proteobacteria,42U77@68525|delta/epsilon subdivisions,2WQ4R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Phosphate-selective porin O and P	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
CMS2_k127_4019750_1	398512.JQKC01000015_gene4640	2.724e-41	153.0	COG0031@1|root,COG0031@2|Bacteria,1V396@1239|Firmicutes,24AZ8@186801|Clostridia,3WJ6S@541000|Ruminococcaceae	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.140	ko:K21949	-	-	R11705	-	ko00000,ko01000	-	-	-	PALP
CMS2_k127_4019750_0	309798.COPRO5265_1373	2.181e-235	738.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,42G2C@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde dehydrogenase family	rocA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh,Pro_dh
CMS2_k127_4027055_1	398512.JQKC01000027_gene3915	8.172e-45	175.0	COG1680@1|root,COG1680@2|Bacteria,1TR9E@1239|Firmicutes,2480P@186801|Clostridia,3WRFA@541000|Ruminococcaceae	186801|Clostridia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_4027055_0	1121335.Clst_1780	1.159e-82	284.0	COG1814@1|root,COG1814@2|Bacteria,1UZVX@1239|Firmicutes,24BSJ@186801|Clostridia,3WMVH@541000|Ruminococcaceae	186801|Clostridia	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
CMS2_k127_4032571_0	1121405.dsmv_2653	3.032e-146	467.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,42RGI@68525|delta/epsilon subdivisions,2WNGP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_33
CMS2_k127_4032571_1	1125863.JAFN01000001_gene2236	5.33e-10	64.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,42NDF@68525|delta/epsilon subdivisions,2WJPS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
CMS2_k127_404422_1	1121405.dsmv_0185	9.062e-30	120.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,42WKN@68525|delta/epsilon subdivisions,2WRXH@28221|Deltaproteobacteria,2MPR6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
CMS2_k127_404422_0	755731.Clo1100_2633	0.0	1523.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4069832_0	536232.CLM_0375	1.531e-252	820.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4069832_1	526224.Bmur_1611	4.479e-07	58.0	COG5464@1|root,COG5464@2|Bacteria,2J7J6@203691|Spirochaetes	203691|Spirochaetes	S	PD-(D/E)XK nuclease family transposase	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_4071725_1	641107.CDLVIII_0710	1.79e-257	835.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
CMS2_k127_4071725_0	573061.Clocel_2487	0.0	1221.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4078901_28	398767.Glov_0178	2.523e-88	300.0	COG2207@1|root,COG2207@2|Bacteria,1MUEM@1224|Proteobacteria,42S1Y@68525|delta/epsilon subdivisions,2WP4J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	AraC-type transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_N,HTH_18
CMS2_k127_4078901_50	767817.Desgi_4483	8.39e-06	48.0	2E3EN@1|root,32YDN@2|Bacteria,1VAU2@1239|Firmicutes,24JSV@186801|Clostridia,2669M@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
CMS2_k127_4078901_41	1292035.H476_2819	1.222e-26	110.0	COG1396@1|root,COG1396@2|Bacteria,1U5FK@1239|Firmicutes,25JSZ@186801|Clostridia,25U3C@186804|Peptostreptococcaceae	186801|Clostridia	K	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
CMS2_k127_4078901_10	335543.Sfum_1616	5.688e-172	555.0	COG0457@1|root,COG0457@2|Bacteria,1PFBA@1224|Proteobacteria,43755@68525|delta/epsilon subdivisions,2WQN6@28221|Deltaproteobacteria,2MSBR@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
CMS2_k127_4078901_5	335543.Sfum_1617	2.103e-284	885.0	COG0457@1|root,COG0457@2|Bacteria,1QXGV@1224|Proteobacteria,42RIF@68525|delta/epsilon subdivisions,2WNC6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
CMS2_k127_4078901_0	335543.Sfum_1618	0.0	1321.0	COG0457@1|root,COG0457@2|Bacteria	335543.Sfum_1618|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4078901_8	595460.RRSWK_00667	1.6e-186	601.0	COG0457@1|root,COG0457@2|Bacteria,2IYBX@203682|Planctomycetes	203682|Planctomycetes	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
CMS2_k127_4078901_3	344747.PM8797T_03935	1.048e-309	975.0	COG0457@1|root,COG0457@2|Bacteria,2IXP3@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,TPR_16
CMS2_k127_4078901_34	671143.DAMO_0259	1.173e-73	257.0	COG1091@1|root,COG1091@2|Bacteria,2NPG4@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
CMS2_k127_4078901_15	1220534.B655_0882	2.152e-133	432.0	COG0451@1|root,arCOG01376@2157|Archaea,2XVGW@28890|Euryarchaeota	28890|Euryarchaeota	M	NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS2_k127_4078901_37	701347.Entcl_1652	1.242e-59	212.0	COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria,3X27J@547|Enterobacter	1236|Gammaproteobacteria	G	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	rfbC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008830,GO:0009058,GO:0009059,GO:0009103,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0046677,GO:0050896,GO:0051716,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2038,iBWG_1329.BWG_1828,iECDH10B_1368.ECDH10B_2188,iECSF_1327.ECSF_1927,iJO1366.b2038,iJR904.b2038,iYL1228.KPN_02488	dTDP_sugar_isom
CMS2_k127_4078901_42	1121422.AUMW01000008_gene478	2.489e-18	86.0	COG1983@1|root,COG1983@2|Bacteria,1VKBQ@1239|Firmicutes,24QU9@186801|Clostridia,262YN@186807|Peptococcaceae	186801|Clostridia	KT	Stress-responsive transcriptional regulator	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
CMS2_k127_4078901_45	706587.Desti_3408	1.05e-10	71.0	COG2887@1|root,COG2887@2|Bacteria,1RAZ0@1224|Proteobacteria,42R3A@68525|delta/epsilon subdivisions,2WN5C@28221|Deltaproteobacteria,2MSBW@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
CMS2_k127_4078901_43	1047013.AQSP01000135_gene1590	1.99e-13	74.0	COG0268@1|root,COG0268@2|Bacteria	2|Bacteria	J	rRNA binding	rpsT	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
CMS2_k127_4078901_40	1235800.C819_01700	9.361e-47	178.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,27JMB@186928|unclassified Lachnospiraceae	186801|Clostridia	S	TIGR00268 family	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,Asn_synthase,NAD_synthase,QueC
CMS2_k127_4078901_44	580327.Tthe_0234	1.47e-12	75.0	COG1633@1|root,COG1633@2|Bacteria,1VGHR@1239|Firmicutes,24QXX@186801|Clostridia,42HHW@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_4078901_16	456320.Mvol_0961	3.75e-133	440.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,23Q3C@183939|Methanococci	183939|Methanococci	L	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
CMS2_k127_4078901_49	439235.Dalk_3936	2.5e-06	55.0	COG1371@1|root,COG1371@2|Bacteria,1NCP6@1224|Proteobacteria,42VQE@68525|delta/epsilon subdivisions,2WS6C@28221|Deltaproteobacteria,2MM59@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
CMS2_k127_4078901_35	1304888.ATWF01000002_gene67	9.979e-70	243.0	COG0349@1|root,COG0349@2|Bacteria,2GFUD@200930|Deferribacteres	200930|Deferribacteres	L	3'-5' exonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_A_exo1
CMS2_k127_4078901_19	580340.Tlie_1294	1.076e-126	419.0	COG0733@1|root,COG0733@2|Bacteria,3T9W5@508458|Synergistetes	508458|Synergistetes	P	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
CMS2_k127_4078901_25	502025.Hoch_2276	2.807e-101	343.0	COG0205@1|root,COG0205@2|Bacteria,1R560@1224|Proteobacteria,42P6N@68525|delta/epsilon subdivisions,2WINA@28221|Deltaproteobacteria,2YVFG@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K00895,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
CMS2_k127_4078901_23	1408473.JHXO01000001_gene2481	1.718e-109	368.0	COG1538@1|root,COG1538@2|Bacteria,4NEMI@976|Bacteroidetes,2FMRJ@200643|Bacteroidia	976|Bacteroidetes	MU	Psort location OuterMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_4078901_1	1408473.JHXO01000001_gene2480	0.0	1228.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,2FWCM@200643|Bacteroidia	976|Bacteroidetes	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS2_k127_4078901_24	1121904.ARBP01000005_gene4863	2.731e-105	354.0	COG0845@1|root,COG0845@2|Bacteria,4NF0X@976|Bacteroidetes,47P9V@768503|Cytophagia	976|Bacteroidetes	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
CMS2_k127_4078901_32	1047013.AQSP01000144_gene913	1.562e-78	276.0	COG0701@1|root,COG0701@2|Bacteria,2NQ6E@2323|unclassified Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1,HMA
CMS2_k127_4078901_39	891968.Anamo_1393	8.142e-52	185.0	COG0822@1|root,COG0822@2|Bacteria,3TB65@508458|Synergistetes	508458|Synergistetes	C	FeS cluster assembly scaffold protein NifU	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
CMS2_k127_4078901_14	246194.CHY_2199	2.354e-143	465.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales	186801|Clostridia	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS2_k127_4078901_46	1396418.BATQ01000047_gene6180	3.228e-08	66.0	2DI2U@1|root,301UZ@2|Bacteria,46VA9@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4078901_51	632518.Calow_1424	0.000888	49.0	COG1434@1|root,COG1434@2|Bacteria,1VA42@1239|Firmicutes,24HKK@186801|Clostridia,42G69@68295|Thermoanaerobacterales	186801|Clostridia	O	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
CMS2_k127_4078901_30	639282.DEFDS_1436	1.027e-79	271.0	COG3155@1|root,COG3155@2|Bacteria,2GEN6@200930|Deferribacteres	200930|Deferribacteres	Q	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
CMS2_k127_4078901_18	1200792.AKYF01000010_gene2389	1.797e-129	421.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,4HAMU@91061|Bacilli,26QMU@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_4078901_21	880073.Calab_0130	5.32e-118	386.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS2_k127_4078901_11	1499967.BAYZ01000097_gene4374	3.594e-168	536.0	COG0160@1|root,COG0160@2|Bacteria	2|Bacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	dgdA	-	2.6.1.11,2.6.1.17,4.1.1.64	ko:K00596,ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS2_k127_4078901_33	649747.HMPREF0083_04907	1.115e-76	261.0	COG1435@1|root,COG1435@2|Bacteria,1TRVM@1239|Firmicutes,4HA4A@91061|Bacilli,26Q9A@186822|Paenibacillaceae	91061|Bacilli	F	Catalyzes the formation of thymidine 5'-phosphate from thymidine	tdk	GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
CMS2_k127_4078901_22	1121098.HMPREF1534_03269	5.573e-114	386.0	COG0737@1|root,COG0737@2|Bacteria,4NGIB@976|Bacteroidetes,2FNGG@200643|Bacteroidia,4AKWZ@815|Bacteroidaceae	976|Bacteroidetes	F	Belongs to the 5'-nucleotidase family	cpdB	-	3.1.3.5,3.1.3.6,3.1.4.16,3.6.1.45	ko:K01119,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
CMS2_k127_4078901_13	235909.GKP09	2.53e-147	486.0	COG1578@1|root,COG1578@2|Bacteria,1UMEP@1239|Firmicutes,4HP1E@91061|Bacilli	91061|Bacilli	L	AlwI restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RE_AlwI
CMS2_k127_4078901_6	235909.GKP08	1.461e-261	821.0	COG0338@1|root,COG3392@1|root,COG0338@2|Bacteria,COG3392@2|Bacteria,1TRDX@1239|Firmicutes,4HDFS@91061|Bacilli,1WGJ2@129337|Geobacillus	91061|Bacilli	L	D12 class N6 adenine-specific DNA methyltransferase	dpnM	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
CMS2_k127_4078901_20	926549.KI421517_gene1627	1.695e-122	408.0	COG4630@1|root,COG4630@2|Bacteria,4NI8H@976|Bacteroidetes,47N48@768503|Cytophagia	976|Bacteroidetes	F	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.17.1.4	ko:K13481	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
CMS2_k127_4078901_4	313606.M23134_06205	1.078e-296	927.0	COG4631@1|root,COG4631@2|Bacteria,4PMEG@976|Bacteroidetes,47KPG@768503|Cytophagia	976|Bacteroidetes	F	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.1.4	ko:K13482	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS2_k127_4078901_9	880073.Calab_3233	7.078e-175	562.0	COG0044@1|root,COG0044@2|Bacteria,2NNWP@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pucH	-	3.5.2.2,3.5.2.5	ko:K01464,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00546	R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
CMS2_k127_4078901_12	880073.Calab_3234	1.254e-150	488.0	COG0402@1|root,COG0402@2|Bacteria,2NQKF@2323|unclassified Bacteria	2|Bacteria	F	Amidohydrolase family	ssnA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS2_k127_4078901_2	880073.Calab_3235	0.0	1154.0	COG1529@1|root,COG1529@2|Bacteria,2NNTR@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	MA20_13970	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5
CMS2_k127_4078901_26	880073.Calab_3236	4.008e-99	332.0	COG1319@1|root,COG1319@2|Bacteria,2NQ9S@2323|unclassified Bacteria	2|Bacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.17.1.4,1.17.1.5,1.2.5.3	ko:K03519,ko:K13479,ko:K20445	ko00230,ko00760,ko01100,ko01120,map00230,map00760,map01100,map01120	M00546	R01720,R01768,R02103,R11168	RC00143,RC00589,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5
CMS2_k127_4078901_38	309807.SRU_2779	2.742e-56	214.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_4078901_31	1499967.BAYZ01000061_gene5930	1.44e-79	273.0	COG0327@1|root,COG0327@2|Bacteria	2|Bacteria	L	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	ybgI	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050896	3.5.4.16	ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	NIF3
CMS2_k127_4078901_36	1499967.BAYZ01000173_gene5811	8.372e-67	232.0	COG0317@1|root,COG1670@1|root,COG0317@2|Bacteria,COG1670@2|Bacteria,2NRYV@2323|unclassified Bacteria	2|Bacteria	J	Acetyltransferase (GNAT) domain	rimJ	-	2.3.1.128,2.7.6.5,3.1.7.2	ko:K01139,ko:K03790	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	Acetyltransf_3,HD_4
CMS2_k127_4078901_7	643562.Daes_2210	2.124e-221	703.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2M8U3@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM ABC transporter related	uup	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
CMS2_k127_4078901_29	161156.JQKW01000008_gene414	7.895e-84	294.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	MatE,Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
CMS2_k127_4078901_27	1168034.FH5T_05545	2.341e-95	320.0	COG0053@1|root,COG0053@2|Bacteria,4NEID@976|Bacteroidetes,2FNNF@200643|Bacteroidia	976|Bacteroidetes	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
CMS2_k127_4078901_17	1237149.C900_05291	1.632e-129	439.0	COG4403@1|root,COG4403@2|Bacteria,4NMZP@976|Bacteroidetes,47U7Z@768503|Cytophagia	976|Bacteroidetes	V	Lanthionine synthetase C-like protein	-	-	-	-	-	-	-	-	-	-	-	-	LANC_like
CMS2_k127_4078901_48	96561.Dole_2865	2.452e-06	51.0	2E6UZ@1|root,331EN@2|Bacteria,1NDI7@1224|Proteobacteria,42W7T@68525|delta/epsilon subdivisions,2WS5H@28221|Deltaproteobacteria,2MM0D@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4109322_0	1458357.BG58_25890	0.0	1435.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,1JZUU@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	amino acid adenylation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,PP-binding,Thioesterase
CMS2_k127_4110289_1	1382306.JNIM01000001_gene228	3.247e-69	244.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,GUN4,Helicase_C,Peptidase_C14
CMS2_k127_4110289_0	1123487.KB892835_gene3683	2.327e-80	284.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,2WHQF@28216|Betaproteobacteria	28216|Betaproteobacteria	T	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
CMS2_k127_4136900_1	573413.Spirs_3325	2.549e-85	291.0	COG2834@1|root,COG2834@2|Bacteria,2J5AT@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS2_k127_4136900_0	575590.HMPREF0156_00435	1.709e-97	334.0	COG3103@1|root,COG3103@2|Bacteria,4NIB7@976|Bacteroidetes	976|Bacteroidetes	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4138957_22	1379698.RBG1_1C00001G0533	1.407e-86	299.0	COG0454@1|root,COG0456@2|Bacteria,2NNUP@2323|unclassified Bacteria	2|Bacteria	K	acetyltransferase	yghO	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_4138957_16	880071.Fleli_2454	4.322e-117	387.0	COG1996@1|root,COG1996@2|Bacteria,4NFZ3@976|Bacteroidetes	976|Bacteroidetes	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4138957_14	313628.LNTAR_24551	1.943e-136	443.0	COG4260@1|root,COG4260@2|Bacteria	2|Bacteria	N	virion core protein, lumpy skin disease virus	ydjI	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DUF4339
CMS2_k127_4138957_29	1216967.L100_09229	2.59e-07	55.0	2AMWJ@1|root,31CTC@2|Bacteria,4PBSE@976|Bacteroidetes,1IIHE@117743|Flavobacteriia,34SCB@308865|Elizabethkingia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4138957_19	1047013.AQSP01000089_gene1184	1.151e-91	319.0	COG0617@1|root,COG0617@2|Bacteria	2|Bacteria	J	CTP:tRNA cytidylyltransferase activity	pcnB	GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004652,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006276,GO:0006378,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0031124,GO:0034641,GO:0043170,GO:0043412,GO:0043631,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974,ko:K07276,ko:K19545	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko01504,ko03016,ko03019	-	-	-	CBS,DHH,HD,PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C,tRNA_NucTran2_2
CMS2_k127_4138957_11	1121920.AUAU01000022_gene2451	9.129e-160	512.0	COG2805@1|root,COG2805@2|Bacteria,3Y316@57723|Acidobacteria	57723|Acidobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS2_k127_4138957_7	648996.Theam_1682	4.662e-246	787.0	COG0013@1|root,COG0013@2|Bacteria,2G3RJ@200783|Aquificae	200783|Aquificae	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
CMS2_k127_4138957_25	1047013.AQSP01000090_gene671	6.308e-35	142.0	COG0741@1|root,COG0741@2|Bacteria,2NPR5@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase SLT domain	slt	-	-	-	-	-	-	-	-	-	-	-	SLT
CMS2_k127_4138957_23	1047013.AQSP01000097_gene1959	1.957e-78	273.0	COG1597@1|root,COG1597@2|Bacteria,2NPQE@2323|unclassified Bacteria	2|Bacteria	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
CMS2_k127_4138957_21	926549.KI421517_gene455	1.916e-88	302.0	COG2234@1|root,COG2234@2|Bacteria,4NIQX@976|Bacteroidetes,47MWW@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS2_k127_4138957_26	1280666.ATVS01000013_gene784	4.88e-25	106.0	COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia,4BZTJ@830|Butyrivibrio	186801|Clostridia	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS2_k127_4138957_18	123214.PERMA_1491	9.896e-101	344.0	COG2204@1|root,COG2204@2|Bacteria,2G3T9@200783|Aquificae	200783|Aquificae	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_4138957_24	1122931.AUAE01000013_gene2068	2.707e-43	173.0	COG3852@1|root,COG3852@2|Bacteria,4PPPV@976|Bacteroidetes,2G17D@200643|Bacteroidia,22ZVH@171551|Porphyromonadaceae	976|Bacteroidetes	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS2_k127_4138957_27	1121481.AUAS01000002_gene3454	1.855e-11	74.0	COG1131@1|root,COG1131@2|Bacteria,4NE3Z@976|Bacteroidetes,47NBH@768503|Cytophagia	976|Bacteroidetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	AAA_21,ABC_tran
CMS2_k127_4138957_8	1047013.AQSP01000140_gene2509	7.061e-235	751.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_4138957_3	536232.CLM_0373	0.0	2170.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4138957_15	711393.AYRX01000103_gene5911	9.682e-134	445.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_4138957_5	1042163.BRLA_c025650	0.0	1166.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15662	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4138957_13	711393.AYRX01000103_gene5911	2.656e-140	464.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_4138957_2	1042163.BRLA_c025650	0.0	2231.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15662	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4138957_4	1196323.ALKF01000205_gene4114	0.0	1716.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4138957_12	509191.AEDB02000067_gene916	8.524e-158	516.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_4138957_6	536232.CLM_0374	0.0	1154.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4138957_1	886882.PPSC2_c0086	0.0	2443.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4138957_10	509191.AEDB02000067_gene916	3.752e-164	534.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_4138957_9	1122917.KB899662_gene2377	1.479e-167	582.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16093	ko01054,map01054	-	-	-	ko00000,ko00001	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_4138957_20	1499967.BAYZ01000009_gene5354	8.585e-91	340.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	-	ko:K16416	ko01052,map01052	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_12,NAD_binding_4,PP-binding,PilZ,Thioesterase,ketoacyl-synt
CMS2_k127_4138957_0	649747.HMPREF0083_00279	0.0	2970.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16123,ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4138957_28	204669.Acid345_3530	1.368e-07	63.0	COG3595@1|root,COG3595@2|Bacteria,3Y4HG@57723|Acidobacteria,2JJ7G@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS2_k127_4138957_17	398512.JQKC01000015_gene4640	4.723e-112	368.0	COG0031@1|root,COG0031@2|Bacteria,1V396@1239|Firmicutes,24AZ8@186801|Clostridia,3WJ6S@541000|Ruminococcaceae	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.140	ko:K21949	-	-	R11705	-	ko00000,ko01000	-	-	-	PALP
CMS2_k127_414055_0	279010.BL01726	0.0	2595.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_414055_1	382464.ABSI01000013_gene1604	7.023e-86	311.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
CMS2_k127_414055_2	1174528.JH992892_gene6453	1.183e-48	190.0	COG1020@1|root,COG1020@2|Bacteria,1G2QF@1117|Cyanobacteria	1117|Cyanobacteria	Q	protein containing a NRPS condensation (Elongation) domain	-	-	-	-	-	-	-	-	-	-	-	-	AATase,Condensation
CMS2_k127_4157300_1	517418.Ctha_1164	2.517e-273	859.0	COG0841@1|root,COG0841@2|Bacteria,1FDHA@1090|Chlorobi	1090|Chlorobi	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS2_k127_4157300_7	517418.Ctha_1165	4.239e-104	351.0	COG0845@1|root,COG0845@2|Bacteria,1FDCQ@1090|Chlorobi	1090|Chlorobi	M	TIGRFAM efflux transporter, RND family, MFP subunit	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
CMS2_k127_4157300_17	429009.Adeg_1796	6.363e-27	112.0	COG1254@1|root,COG1254@2|Bacteria,1UEN2@1239|Firmicutes,25JM5@186801|Clostridia,42HJX@68295|Thermoanaerobacterales	186801|Clostridia	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
CMS2_k127_4157300_15	1484460.JSWG01000004_gene2650	2.868e-46	178.0	COG0491@1|root,COG0491@2|Bacteria,4NHG1@976|Bacteroidetes,1HYC1@117743|Flavobacteriia	976|Bacteroidetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_4157300_2	1047013.AQSP01000123_gene1522	2.149e-252	798.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_4157300_4	247490.KSU1_C0714	1.649e-134	484.0	COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes	203682|Planctomycetes	O	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
CMS2_k127_4157300_5	694427.Palpr_2116	1.57e-133	481.0	COG3656@1|root,COG4886@1|root,COG3656@2|Bacteria,COG4886@2|Bacteria,4NHDQ@976|Bacteroidetes,2FTSH@200643|Bacteroidia,22Y91@171551|Porphyromonadaceae	976|Bacteroidetes	S	Fibronectin type 3 domain	-	-	-	ko:K21571	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_4157300_10	439235.Dalk_0237	1.546e-93	351.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_4157300_16	1122223.KB890700_gene2046	2.531e-37	162.0	COG4447@1|root,COG4447@2|Bacteria,1WJIB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4157300_13	439235.Dalk_0237	1.156e-82	302.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_4157300_9	536227.CcarbDRAFT_4777	3.221e-96	320.0	COG2872@1|root,COG2872@2|Bacteria,1UHS6@1239|Firmicutes,24AK0@186801|Clostridia,36GRN@31979|Clostridiaceae	186801|Clostridia	S	Threonyl alanyl tRNA synthetase SAD	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
CMS2_k127_4157300_3	1121403.AUCV01000005_gene261	4.906e-176	569.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
CMS2_k127_4157300_0	1237149.C900_05550	1.176e-286	899.0	COG1506@1|root,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,47KF8@768503|Cytophagia	976|Bacteroidetes	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
CMS2_k127_4157300_14	1410653.JHVC01000035_gene802	3.051e-47	179.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia,36DW4@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
CMS2_k127_4157300_19	1313421.JHBV01000029_gene2024	8.997e-18	87.0	COG3291@1|root,COG3391@1|root,COG4409@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4409@2|Bacteria,4PPK0@976|Bacteroidetes	976|Bacteroidetes	G	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4157300_6	1047013.AQSP01000045_gene108	2.45e-105	357.0	COG1748@1|root,COG1748@2|Bacteria,2NNZ1@2323|unclassified Bacteria	2|Bacteria	E	Saccharopine dehydrogenase C-terminal domain	lys2	-	1.5.1.10	ko:K00293	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R02315	RC00215,RC00225	ko00000,ko00001,ko00002,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
CMS2_k127_4157300_8	1121918.ARWE01000001_gene3039	5.338e-101	338.0	COG0668@1|root,COG0668@2|Bacteria,1PMY3@1224|Proteobacteria,42M4K@68525|delta/epsilon subdivisions,2WWCN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
CMS2_k127_4157300_11	351160.RCIX1302	1.556e-92	319.0	arCOG12580@1|root,arCOG12580@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4157300_18	192952.MM_2929	2.991e-21	95.0	arCOG06883@1|root,arCOG06883@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2334,DZR
CMS2_k127_4157300_12	304371.MCP_0158	9.508e-88	294.0	arCOG01917@1|root,arCOG01917@2157|Archaea	2157|Archaea	M	deoxyhypusine monooxygenase activity	-	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	DZR,ECH_1,FHA,zf-ribbon_3,zinc_ribbon_2
CMS2_k127_4160584_0	1499967.BAYZ01000125_gene2602	1.574e-81	278.0	COG3967@1|root,COG3967@2|Bacteria	2|Bacteria	M	Belongs to the short-chain dehydrogenases reductases (SDR) family	dltE	-	-	ko:K14189	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
CMS2_k127_4160584_2	1265505.ATUG01000001_gene4061	1.425e-43	164.0	COG0589@1|root,COG0745@1|root,COG0589@2|Bacteria,COG0745@2|Bacteria,1MZPD@1224|Proteobacteria,42U2Y@68525|delta/epsilon subdivisions,2WQ1I@28221|Deltaproteobacteria,2MQ25@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Usp
CMS2_k127_4160584_1	1304885.AUEY01000001_gene3203	1.749e-58	210.0	COG0785@1|root,COG0785@2|Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
CMS2_k127_4160584_3	1499967.BAYZ01000050_gene2875	2.736e-29	122.0	2DPAK@1|root,33193@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4160584_4	1345695.CLSA_c10090	1.584e-08	60.0	COG1131@1|root,COG3279@1|root,COG1131@2|Bacteria,COG3279@2|Bacteria,1TSA4@1239|Firmicutes,24DGS@186801|Clostridia,36FPG@31979|Clostridiaceae	186801|Clostridia	KTV	LytTr DNA-binding domain	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,LytTR
CMS2_k127_4168026_4	204536.SULAZ_0255	6.15e-16	80.0	COG2886@1|root,COG2886@2|Bacteria	2|Bacteria	E	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
CMS2_k127_4168026_1	1304885.AUEY01000017_gene3759	1.852e-26	109.0	COG1598@1|root,COG1598@2|Bacteria,1NCC0@1224|Proteobacteria,434UG@68525|delta/epsilon subdivisions,2WZ5D@28221|Deltaproteobacteria,2MNZY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
CMS2_k127_4168026_3	1122222.AXWR01000023_gene1538	2.243e-17	83.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
CMS2_k127_4172028_1	1161401.ASJA01000025_gene210	1.616e-45	173.0	COG0457@1|root,COG0457@2|Bacteria,1RCUA@1224|Proteobacteria,2U8NP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
CMS2_k127_4172028_0	102125.Xen7305DRAFT_00003710	9.986e-50	191.0	COG0079@1|root,COG0079@2|Bacteria,1FZV3@1117|Cyanobacteria,3VIDI@52604|Pleurocapsales	1117|Cyanobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_4172028_2	68170.KL590482_gene599	4.146e-05	55.0	COG1562@1|root,COG1562@2|Bacteria,2GJN2@201174|Actinobacteria,4DY9Y@85010|Pseudonocardiales	201174|Actinobacteria	I	phytoene synthase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
CMS2_k127_4183688_25	522772.Dacet_0297	2.175e-40	164.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	PPC,Peptidase_C14,TPR_8
CMS2_k127_4183688_10	1121904.ARBP01000001_gene5914	4.272e-106	373.0	COG4249@1|root,COG4249@2|Bacteria,4NH9I@976|Bacteroidetes,47XC3@768503|Cytophagia	976|Bacteroidetes	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
CMS2_k127_4183688_34	1408473.JHXO01000013_gene547	9.22e-23	98.0	2E8MC@1|root,332YU@2|Bacteria,4NUZI@976|Bacteroidetes,2FVNK@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4183688_47	203124.Tery_1186	0.000215	44.0	COG1196@1|root,COG4372@1|root,COG1196@2|Bacteria,COG4372@2|Bacteria,1GAA0@1117|Cyanobacteria,1HH17@1150|Oscillatoriales	1117|Cyanobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4183688_26	1469607.KK073768_gene3348	5.717e-40	156.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1HK1F@1161|Nostocales	1117|Cyanobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_1,TPR_12,TPR_7,TPR_8
CMS2_k127_4183688_30	693661.Arcve_1273	6.013e-30	121.0	COG1669@1|root,arCOG01206@2157|Archaea,2Y02Z@28890|Euryarchaeota,246IH@183980|Archaeoglobi	183980|Archaeoglobi	S	DNA polymerase beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
CMS2_k127_4183688_28	498848.TaqDRAFT_3958	6.98e-35	136.0	COG2361@1|root,COG2361@2|Bacteria,1WKJ0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function DUF86	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	DUF86,NTP_transf_2
CMS2_k127_4183688_45	518766.Rmar_0390	4.332e-06	56.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_4183688_9	1499967.BAYZ01000095_gene4087	1.792e-108	357.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
CMS2_k127_4183688_12	1232437.KL662042_gene2005	5.638e-99	329.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2MHNA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
CMS2_k127_4183688_4	1265505.ATUG01000001_gene3443	1.011e-125	409.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,42Q6C@68525|delta/epsilon subdivisions,2WMD6@28221|Deltaproteobacteria,2MHY6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
CMS2_k127_4183688_43	224324.aq_507	8.43e-09	61.0	COG1708@1|root,COG1708@2|Bacteria,2G4CI@200783|Aquificae	200783|Aquificae	S	Nucleotidyltransferase domain	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
CMS2_k127_4183688_35	525897.Dbac_0130	2.962e-20	96.0	COG0138@1|root,COG0138@2|Bacteria	2|Bacteria	F	bifunctional purine biosynthesis protein purh	-	-	-	-	-	-	-	-	-	-	-	-	NTase_sub_bind
CMS2_k127_4183688_39	391603.FBALC1_08033	7.142e-15	84.0	COG1595@1|root,COG1595@2|Bacteria,4NF93@976|Bacteroidetes,1HX2Z@117743|Flavobacteriia	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_4183688_46	1128421.JAGA01000002_gene580	0.0001326	51.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
CMS2_k127_4183688_31	1047013.AQSP01000037_gene1325	1.153e-27	118.0	COG0250@1|root,COG0250@2|Bacteria	2|Bacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601,ko:K05785	-	-	-	-	ko00000,ko03000,ko03009,ko03021	-	-	-	KOW,NusG
CMS2_k127_4183688_27	29581.BW37_00653	1.284e-38	160.0	COG3765@1|root,COG3765@2|Bacteria,1NKK1@1224|Proteobacteria,2W3P2@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4183688_0	945713.IALB_1425	1.096e-164	529.0	COG0677@1|root,COG0677@2|Bacteria	2|Bacteria	M	UDP-N-acetyl-D-mannosamine dehydrogenase activity	-	-	1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520	-	R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS2_k127_4183688_19	1120998.AUFC01000009_gene2109	2.655e-78	266.0	COG0110@1|root,COG0110@2|Bacteria,1TT21@1239|Firmicutes,24CCH@186801|Clostridia	186801|Clostridia	M	Bacterial transferase hexapeptide	wbpD	-	2.3.1.201	ko:K13018	ko00520,map00520	-	R10100	RC00004,RC00166	ko00000,ko00001,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2
CMS2_k127_4183688_2	880072.Desac_2651	5.027e-148	477.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42M4C@68525|delta/epsilon subdivisions,2WJ1Q@28221|Deltaproteobacteria,2MR0E@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Beta-eliminating lyase	degT	-	2.6.1.98	ko:K13017	ko00520,map00520	-	R10141	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_4183688_1	96561.Dole_1280	1.151e-159	507.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42MI8@68525|delta/epsilon subdivisions,2WJDT@28221|Deltaproteobacteria,2MJA6@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	PFAM NAD-dependent epimerase dehydratase	uxs	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
CMS2_k127_4183688_3	269797.Mbar_A0035	8.706e-148	473.0	COG0451@1|root,arCOG04627@2157|Archaea,2XW3U@28890|Euryarchaeota,2NAEE@224756|Methanomicrobia	224756|Methanomicrobia	M	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
CMS2_k127_4183688_42	264732.Moth_1929	6.288e-09	69.0	COG1807@1|root,COG1807@2|Bacteria,1UT2K@1239|Firmicutes,250ZW@186801|Clostridia,42IBB@68295|Thermoanaerobacterales	186801|Clostridia	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4183688_7	653733.Selin_0226	9.08e-111	367.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_4183688_18	368407.Memar_0959	5.263e-86	296.0	COG1817@1|root,arCOG01395@2157|Archaea,2XT3W@28890|Euryarchaeota,2NAFU@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
CMS2_k127_4183688_14	1336233.JAEH01000002_gene1343	1.038e-92	323.0	2DKWY@1|root,30NX3@2|Bacteria,1RBMB@1224|Proteobacteria,1S5SW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4183688_16	1336233.JAEH01000002_gene1343	1.278e-90	318.0	2DKWY@1|root,30NX3@2|Bacteria,1RBMB@1224|Proteobacteria,1S5SW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4183688_15	1336233.JAEH01000002_gene1343	6.075e-92	323.0	2DKWY@1|root,30NX3@2|Bacteria,1RBMB@1224|Proteobacteria,1S5SW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4183688_13	1336233.JAEH01000002_gene1343	2.35e-93	325.0	2DKWY@1|root,30NX3@2|Bacteria,1RBMB@1224|Proteobacteria,1S5SW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4183688_11	1336233.JAEH01000002_gene1343	9.964e-104	358.0	2DKWY@1|root,30NX3@2|Bacteria,1RBMB@1224|Proteobacteria,1S5SW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4183688_44	378806.STAUR_3913	1.188e-06	63.0	COG4932@1|root,COG4932@2|Bacteria,1Q342@1224|Proteobacteria,433XR@68525|delta/epsilon subdivisions,2X40S@28221|Deltaproteobacteria,2YXUG@29|Myxococcales	28221|Deltaproteobacteria	M	Epidermal growth factor-like domain.	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,EGF_3,LTD
CMS2_k127_4183688_5	1499967.BAYZ01000008_gene5408	2.637e-124	449.0	COG2931@1|root,COG2931@2|Bacteria,2NQ7A@2323|unclassified Bacteria	2|Bacteria	Q	Clostripain family	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Calx-beta,DUF4214,DUF4347,Peptidase_C11,SLH,SWM_repeat
CMS2_k127_4183688_17	1236541.BALL01000037_gene3711	8.412e-90	338.0	COG1404@1|root,COG3291@1|root,COG4935@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG4935@2|Bacteria,1MU3S@1224|Proteobacteria,1RSP9@1236|Gammaproteobacteria,2Q9PE@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Proprotein convertase P-domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD,P_proprotein,Peptidase_S8
CMS2_k127_4183688_6	1336233.JAEH01000002_gene1343	1.173e-120	406.0	2DKWY@1|root,30NX3@2|Bacteria,1RBMB@1224|Proteobacteria,1S5SW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4183688_21	1537915.JU57_10170	1.521e-71	251.0	COG1682@1|root,COG1682@2|Bacteria,1N0X3@1224|Proteobacteria,42PRV@68525|delta/epsilon subdivisions,2YTQE@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	U	Transport permease protein	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
CMS2_k127_4183688_8	1121405.dsmv_2646	1.555e-108	367.0	COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,42NNW@68525|delta/epsilon subdivisions,2WMWA@28221|Deltaproteobacteria,2MJQ5@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	PFAM ABC transporter	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
CMS2_k127_4183688_33	237368.SCABRO_02706	5.042e-23	112.0	COG1032@1|root,COG1032@2|Bacteria,2J1DC@203682|Planctomycetes	203682|Planctomycetes	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_4183688_37	579137.Metvu_0067	1.647e-16	91.0	arCOG09746@1|root,arCOG09746@2157|Archaea,2Y4VG@28890|Euryarchaeota	28890|Euryarchaeota	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
CMS2_k127_4183688_23	118163.Ple7327_2124	3.778e-57	209.0	COG3551@1|root,COG3551@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_transf_4,Glyco_transf_41,Glycos_transf_1,Glycos_transf_2,Sulfotransfer_3
CMS2_k127_4183688_24	269798.CHU_0912	1.211e-45	178.0	COG1216@1|root,COG1216@2|Bacteria,4NKAZ@976|Bacteroidetes,47QI0@768503|Cytophagia	976|Bacteroidetes	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_4183688_20	592029.DDD_2273	2.291e-77	267.0	2EWJQ@1|root,33PXW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4183688_36	118166.JH976537_gene850	3.838e-20	101.0	COG0615@1|root,COG0615@2|Bacteria,1G8ZG@1117|Cyanobacteria,1HC32@1150|Oscillatoriales	1117|Cyanobacteria	IM	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
CMS2_k127_4183688_32	1173023.KE650771_gene3842	3.083e-27	125.0	COG0438@1|root,COG0438@2|Bacteria,1GBQ3@1117|Cyanobacteria	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4183688_40	237368.SCABRO_00933	3.201e-14	76.0	COG3119@1|root,COG3119@2|Bacteria,2IXMP@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.14	ko:K01137	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078,M00079	R07808,R07819	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4976,Sulfatase
CMS2_k127_4183688_48	266117.Rxyl_3110	0.0004585	44.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4CS0X@84995|Rubrobacteria	84995|Rubrobacteria	P	PFAM sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_4183688_29	247490.KSU1_C0544	1.493e-31	143.0	COG3591@1|root,COG3591@2|Bacteria,2J472@203682|Planctomycetes	203682|Planctomycetes	E	Trypsin-like serine protease	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4183688_22	694427.Palpr_2116	9.801e-58	226.0	COG3656@1|root,COG4886@1|root,COG3656@2|Bacteria,COG4886@2|Bacteria,4NHDQ@976|Bacteroidetes,2FTSH@200643|Bacteroidia,22Y91@171551|Porphyromonadaceae	976|Bacteroidetes	S	Fibronectin type 3 domain	-	-	-	ko:K21571	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_4193297_0	1122925.KB895390_gene1498	1.205e-217	715.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_4193297_1	215803.DB30_3970	6.33e-16	81.0	COG3266@1|root,COG3568@1|root,COG3266@2|Bacteria,COG3568@2|Bacteria,1N2ZJ@1224|Proteobacteria,42WUR@68525|delta/epsilon subdivisions,2WSUA@28221|Deltaproteobacteria,2YUA6@29|Myxococcales	28221|Deltaproteobacteria	PQ	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,LTD
CMS2_k127_4194797_10	509191.AEDB02000067_gene917	7.922e-94	326.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WNP0@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4194797_5	755731.Clo1100_2632	0.0	1679.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4194797_6	1121121.KB894288_gene2765	0.0	1570.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_4194797_8	98439.AJLL01000096_gene4134	0.0	1329.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4194797_0	1449347.JQLN01000004_gene6882	0.0	1967.0	COG3321@1|root,COG3321@2|Bacteria,2H477@201174|Actinobacteria,2M0A0@2063|Kitasatospora	201174|Actinobacteria	Q	Acyl transferase domain in polyketide synthase (PKS) enzymes.	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2,AMP-binding,AMP-binding_C,Acyl_transf_1,Docking,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
CMS2_k127_4194797_9	1157490.EL26_11890	2.59e-149	539.0	COG0318@1|root,COG0318@2|Bacteria,1UZQF@1239|Firmicutes,4HECX@91061|Bacilli	91061|Bacilli	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,PP-binding
CMS2_k127_4194797_4	1501230.ET33_18930	0.0	1692.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	bacC	-	-	ko:K16122	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
CMS2_k127_4194797_1	1121121.KB894288_gene2765	0.0	1746.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_4194797_2	1034769.KB910518_gene3552	0.0	1742.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4194797_7	63737.Npun_F2181	0.0	1428.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_4194797_3	649747.HMPREF0083_00279	0.0	1699.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16123,ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4203200_0	755731.Clo1100_0890	0.0	1244.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4204434_1	509191.AEDB02000067_gene919	5.987e-214	698.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4204434_2	509191.AEDB02000067_gene916	2.779e-202	644.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_4204434_0	1408422.JHYF01000017_gene1871	4.178e-237	762.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4209154_1	1408422.JHYF01000001_gene2874	1.514e-312	994.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654,ko:K15664	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4209154_3	509191.AEDB02000067_gene916	2.965e-206	656.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_4209154_2	1009370.ALO_00920	1.601e-281	916.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	909932|Negativicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_4209154_0	1121121.KB894288_gene2769	0.0	1044.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_4211702_2	439481.Aboo_0320	7.113e-170	557.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,3F2GC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
CMS2_k127_4211702_6	696281.Desru_1723	2.261e-32	139.0	COG0857@1|root,COG0857@2|Bacteria,1UFKM@1239|Firmicutes,25M79@186801|Clostridia,260XJ@186807|Peptococcaceae	186801|Clostridia	C	DRTGG domain protein	-	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
CMS2_k127_4211702_0	945713.IALB_2442	0.0	1176.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria	2|Bacteria	I	cobalamin binding	mutB	-	5.4.99.2	ko:K01847,ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
CMS2_k127_4211702_1	945713.IALB_2440	3.545e-217	696.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria	2|Bacteria	I	cobalamin binding	mutA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016999,GO:0017144,GO:0019541,GO:0019678,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046459,GO:0071704,GO:0071944	2.7.7.7,5.4.99.2,5.4.99.63	ko:K01847,ko:K03763,ko:K14447	ko00230,ko00240,ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,ko03030,ko03430,ko03440,map00230,map00240,map00280,map00630,map00640,map00720,map01100,map01120,map01200,map03030,map03430,map03440	M00260,M00373,M00376,M00741	R00375,R00376,R00377,R00378,R00833,R09292	RC00395,RC02795,RC02835	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	MM_CoA_mutase
CMS2_k127_4211702_4	1499967.BAYZ01000048_gene2706	1.033e-117	391.0	COG3616@1|root,COG3616@2|Bacteria,2NPWK@2323|unclassified Bacteria	2|Bacteria	E	Putative serine dehydratase domain	-	-	4.3.1.27	ko:K20757	-	-	-	-	ko00000,ko01000	-	-	-	Ala_racemase_N,D-ser_dehydrat
CMS2_k127_4211702_7	1121377.KB906400_gene1411	4.947e-11	66.0	COG2329@1|root,COG2329@2|Bacteria,1WNAU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
CMS2_k127_4211702_3	1047013.AQSP01000142_gene127	4.386e-118	388.0	COG2070@1|root,COG2070@2|Bacteria,2NPGR@2323|unclassified Bacteria	2|Bacteria	S	Nitronate monooxygenase	fabK	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO,ThiG
CMS2_k127_4211702_8	635013.TherJR_1734	1.805e-08	66.0	COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,24AGW@186801|Clostridia,260PT@186807|Peptococcaceae	186801|Clostridia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
CMS2_k127_4211702_5	762966.HMPREF9439_00585	3.956e-43	173.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2VHJ9@28216|Betaproteobacteria,4PRGW@995019|Sutterellaceae	28216|Betaproteobacteria	S	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
CMS2_k127_4213591_1	1121007.AUML01000006_gene3132	4.14e-140	457.0	COG3367@1|root,COG3367@2|Bacteria,4NGXN@976|Bacteroidetes,1HZA0@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
CMS2_k127_4213591_0	1123252.ATZF01000026_gene4143	3.552e-145	469.0	COG3457@1|root,COG3457@2|Bacteria,1TNYJ@1239|Firmicutes,4HBIA@91061|Bacilli	91061|Bacilli	E	Racemase	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
CMS2_k127_4213591_2	1499967.BAYZ01000028_gene1366	7.414e-111	377.0	COG3653@1|root,COG3653@2|Bacteria,2NNQ0@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	dan	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
CMS2_k127_4213591_3	1379698.RBG1_1C00001G0540	8.304e-06	54.0	COG1520@1|root,COG1520@2|Bacteria,2NQ51@2323|unclassified Bacteria	2|Bacteria	O	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,SBBP
CMS2_k127_42221_1	755731.Clo1100_1305	0.0	1810.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36QT1@31979|Clostridiaceae	186801|Clostridia	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_31,NAD_binding_4,PP-binding,ketoacyl-synt
CMS2_k127_42221_4	509191.AEDB02000067_gene916	2.597e-191	612.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_42221_2	118005.AWNK01000004_gene1064	0.0	1190.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_42221_8	1123368.AUIS01000014_gene2292	2.293e-106	395.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_42221_15	1121007.AUML01000042_gene3405	3.783e-08	62.0	2E7G4@1|root,331Z0@2|Bacteria,4PGSD@976|Bacteroidetes,1IHIW@117743|Flavobacteriia,2YH20@290174|Aquimarina	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_42221_3	1168289.AJKI01000015_gene2185	1.922e-215	678.0	COG0493@1|root,COG0493@2|Bacteria,4NG9R@976|Bacteroidetes,2FMJF@200643|Bacteroidia,3XJ6Y@558415|Marinilabiliaceae	976|Bacteroidetes	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	gltA	-	1.3.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K17722	ko00240,ko00250,ko00410,ko00770,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00410,map00770,map00910,map01100,map01110,map01120,map01130,map01230	M00046	R00093,R00114,R00248,R00977,R01414,R11026	RC00006,RC00010,RC00072,RC00123,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,Fer4_20,NAD_binding_1,Pyr_redox_2
CMS2_k127_42221_7	742766.HMPREF9455_02600	2.835e-115	377.0	COG0543@1|root,COG0543@2|Bacteria,4NJ0I@976|Bacteroidetes,2FNBW@200643|Bacteroidia,22WH8@171551|Porphyromonadaceae	976|Bacteroidetes	C	Ferredoxin-NADP reductase	gltD	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
CMS2_k127_42221_9	313606.M23134_07246	9.731e-104	372.0	COG2203@1|root,COG2208@1|root,COG3292@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3292@2|Bacteria,4NKGA@976|Bacteroidetes,47TQU@768503|Cytophagia	976|Bacteroidetes	T	Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,SpoIIE,Y_Y_Y
CMS2_k127_42221_13	555779.Dthio_PD0402	4.549e-21	95.0	COG3905@1|root,COG3905@2|Bacteria	2|Bacteria	K	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
CMS2_k127_42221_11	555779.Dthio_PD0778	1.594e-24	108.0	COG1569@1|root,COG1569@2|Bacteria,1NJ68@1224|Proteobacteria	1224|Proteobacteria	S	nucleic acid-binding protein, contains PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
CMS2_k127_42221_10	706587.Desti_2578	9.779e-48	181.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_42221_5	926549.KI421517_gene1746	1.5e-145	484.0	COG0652@1|root,COG1413@1|root,COG0652@2|Bacteria,COG1413@2|Bacteria,4PM5K@976|Bacteroidetes,47MDR@768503|Cytophagia	976|Bacteroidetes	M	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	HEAT,HEAT_2,Pro_isomerase
CMS2_k127_42221_16	1403313.AXBR01000014_gene2201	0.0004185	44.0	2BTFW@1|root,32NN5@2|Bacteria,1UB53@1239|Firmicutes,4IMHN@91061|Bacilli,1ZK6C@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_42221_12	1379698.RBG1_1C00001G0060	1.941e-22	102.0	COG1983@1|root,COG1983@2|Bacteria,2NQ85@2323|unclassified Bacteria	2|Bacteria	KT	PspC domain	pspC	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
CMS2_k127_42221_6	661478.OP10G_2783	1.338e-141	481.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,PD40,Peptidase_S9
CMS2_k127_42221_0	573061.Clocel_2482	0.0	2442.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4235723_1	394503.Ccel_2381	1.088e-194	658.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_31,PP-binding,ketoacyl-synt
CMS2_k127_4235723_2	1123376.AUIU01000011_gene877	6.61e-42	179.0	COG0476@1|root,COG0476@2|Bacteria	2|Bacteria	H	Involved in molybdopterin and thiamine biosynthesis, family 2	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
CMS2_k127_4235723_0	1087481.AGFX01000012_gene3138	0.0	2859.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	fusAA	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_4240406_12	1047013.AQSP01000076_gene1467	2.559e-59	212.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_4240406_1	1047013.AQSP01000142_gene184	9.455e-224	717.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_4240406_29	7897.ENSLACP00000004230	6.887e-08	65.0	KOG3599@1|root,KOG3599@2759|Eukaryota,38DQ4@33154|Opisthokonta,3BCZ5@33208|Metazoa,3CYFS@33213|Bilateria,485XP@7711|Chordata,48YBW@7742|Vertebrata	33208|Metazoa	PT	metanephric distal tubule morphogenesis	PKD1	GO:0000003,GO:0000079,GO:0000139,GO:0001501,GO:0001502,GO:0001568,GO:0001655,GO:0001656,GO:0001701,GO:0001763,GO:0001822,GO:0001823,GO:0001889,GO:0001890,GO:0001892,GO:0001932,GO:0001934,GO:0001944,GO:0001945,GO:0002009,GO:0002133,GO:0003006,GO:0003338,GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005262,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005794,GO:0005798,GO:0005886,GO:0005887,GO:0005929,GO:0006355,GO:0006357,GO:0006464,GO:0006468,GO:0006611,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0006873,GO:0006874,GO:0006875,GO:0006886,GO:0006913,GO:0006950,GO:0007049,GO:0007050,GO:0007154,GO:0007155,GO:0007156,GO:0007160,GO:0007161,GO:0007163,GO:0007165,GO:0007204,GO:0007259,GO:0007275,GO:0007346,GO:0007399,GO:0007417,GO:0007507,GO:0007548,GO:0008104,GO:0008150,GO:0008152,GO:0008324,GO:0009581,GO:0009582,GO:0009605,GO:0009612,GO:0009628,GO:0009653,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009986,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010562,GO:0010564,GO:0010604,GO:0010628,GO:0012505,GO:0015031,GO:0015075,GO:0015085,GO:0015267,GO:0015318,GO:0015833,GO:0016020,GO:0016021,GO:0016310,GO:0016323,GO:0016328,GO:0018105,GO:0018193,GO:0018209,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0019725,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0021510,GO:0021915,GO:0022402,GO:0022414,GO:0022610,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0023052,GO:0030001,GO:0030003,GO:0030010,GO:0030155,GO:0030162,GO:0030323,GO:0030324,GO:0030660,GO:0031090,GO:0031224,GO:0031226,GO:0031253,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031399,GO:0031401,GO:0031410,GO:0031514,GO:0031589,GO:0031657,GO:0031659,GO:0031982,GO:0031984,GO:0032092,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032886,GO:0032991,GO:0033036,GO:0033043,GO:0033674,GO:0034220,GO:0034405,GO:0034613,GO:0035239,GO:0035295,GO:0035556,GO:0036211,GO:0036303,GO:0042176,GO:0042325,GO:0042327,GO:0042592,GO:0042886,GO:0042994,GO:0042995,GO:0043009,GO:0043085,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043230,GO:0043231,GO:0043393,GO:0043412,GO:0043433,GO:0043549,GO:0043588,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044325,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044441,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045184,GO:0045185,GO:0045737,GO:0045786,GO:0045787,GO:0045859,GO:0045860,GO:0045893,GO:0045935,GO:0045937,GO:0045944,GO:0046873,GO:0046907,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048565,GO:0048568,GO:0048608,GO:0048705,GO:0048729,GO:0048731,GO:0048732,GO:0048754,GO:0048806,GO:0048856,GO:0048878,GO:0050789,GO:0050790,GO:0050794,GO:0050801,GO:0050896,GO:0050982,GO:0051090,GO:0051098,GO:0051099,GO:0051128,GO:0051168,GO:0051169,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051216,GO:0051220,GO:0051234,GO:0051235,GO:0051246,GO:0051247,GO:0051252,GO:0051254,GO:0051338,GO:0051347,GO:0051480,GO:0051493,GO:0051606,GO:0051641,GO:0051649,GO:0051716,GO:0051726,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055085,GO:0055123,GO:0060170,GO:0060236,GO:0060255,GO:0060428,GO:0060429,GO:0060541,GO:0060562,GO:0060674,GO:0060993,GO:0061008,GO:0061136,GO:0061138,GO:0061326,GO:0061333,GO:0061448,GO:0061458,GO:0065007,GO:0065008,GO:0065009,GO:0070062,GO:0070507,GO:0070588,GO:0070727,GO:0070838,GO:0071702,GO:0071704,GO:0071705,GO:0071900,GO:0071902,GO:0071944,GO:0072001,GO:0072006,GO:0072009,GO:0072014,GO:0072017,GO:0072021,GO:0072028,GO:0072044,GO:0072070,GO:0072073,GO:0072078,GO:0072080,GO:0072088,GO:0072156,GO:0072163,GO:0072164,GO:0072170,GO:0072173,GO:0072176,GO:0072177,GO:0072205,GO:0072207,GO:0072210,GO:0072218,GO:0072234,GO:0072235,GO:0072236,GO:0072237,GO:0072243,GO:0072273,GO:0072282,GO:0072287,GO:0072358,GO:0072359,GO:0072503,GO:0072507,GO:0072511,GO:0080090,GO:0090224,GO:0097696,GO:0097708,GO:0098588,GO:0098590,GO:0098609,GO:0098655,GO:0098660,GO:0098662,GO:0098742,GO:0098743,GO:0098771,GO:0098791,GO:0098805,GO:0120025,GO:0120038,GO:1901564,GO:1901987,GO:1901990,GO:1902680,GO:1902806,GO:1903050,GO:1903362,GO:1903506,GO:1903508,GO:1903561,GO:1904029,GO:1904031,GO:2000045,GO:2000112,GO:2001141	-	ko:K04985	-	-	-	-	ko00000,ko04040,ko04091,ko04812	1.A.5.1.1	-	-	LRR_8,Lectin_C,PKD,PKD_channel,PLAT,REJ,WSC
CMS2_k127_4240406_23	456442.Mboo_1423	1.54e-17	98.0	COG0068@1|root,COG3291@1|root,arCOG03991@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG03956@2157|Archaea,arCOG03991@2157|Archaea,2XUY6@28890|Euryarchaeota,2NAFS@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PKD
CMS2_k127_4240406_5	882378.RBRH_00535	3.037e-129	427.0	COG0308@1|root,COG0308@2|Bacteria,1NQIW@1224|Proteobacteria,2WA6B@28216|Betaproteobacteria,1K252@119060|Burkholderiaceae	28216|Betaproteobacteria	E	beta subunit of N-acylethanolamine-hydrolyzing acid amidase	-	-	-	-	-	-	-	-	-	-	-	-	NAAA-beta,Phospholip_B
CMS2_k127_4240406_2	1411123.JQNH01000001_gene1616	5.471e-220	698.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CMS2_k127_4240406_19	177439.DP1866	8.777e-30	123.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WQ7I@28221|Deltaproteobacteria,2MKG1@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspA-1	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS2_k127_4240406_3	1265503.KB905162_gene3593	2.697e-156	519.0	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria,2Q7GY@267889|Colwelliaceae	1236|Gammaproteobacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_4240406_10	880073.Calab_0994	9.799e-67	238.0	2BJP3@1|root,32T1G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4240406_27	7739.XP_002587508.1	4.713e-12	76.0	28P57@1|root,2QVS2@2759|Eukaryota,39SH0@33154|Opisthokonta,3BCJZ@33208|Metazoa,3CV5R@33213|Bilateria,484WU@7711|Chordata	33208|Metazoa	S	Sphingomyelin phosphodiesterase 3	SMPD3	GO:0000137,GO:0001505,GO:0002244,GO:0002376,GO:0002520,GO:0002790,GO:0003008,GO:0003012,GO:0003013,GO:0003018,GO:0003674,GO:0003824,GO:0004620,GO:0004767,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005795,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006665,GO:0006684,GO:0006685,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006874,GO:0006875,GO:0006936,GO:0006939,GO:0007154,GO:0007165,GO:0007267,GO:0007275,GO:0007568,GO:0008015,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009889,GO:0009891,GO:0009893,GO:0009914,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010556,GO:0010646,GO:0010647,GO:0010817,GO:0012505,GO:0014820,GO:0014824,GO:0014829,GO:0015696,GO:0015833,GO:0015844,GO:0015850,GO:0015872,GO:0015893,GO:0016020,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0017157,GO:0019216,GO:0019222,GO:0019637,GO:0019725,GO:0023051,GO:0023052,GO:0023056,GO:0023061,GO:0030003,GO:0030072,GO:0030097,GO:0030149,GO:0030154,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031984,GO:0031985,GO:0032501,GO:0032502,GO:0032879,GO:0032940,GO:0034097,GO:0034248,GO:0034250,GO:0034641,GO:0035150,GO:0035296,GO:0042221,GO:0042310,GO:0042493,GO:0042578,GO:0042592,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045428,GO:0045429,GO:0045834,GO:0045921,GO:0046434,GO:0046466,GO:0046879,GO:0046889,GO:0046890,GO:0046903,GO:0048513,GO:0048518,GO:0048522,GO:0048534,GO:0048583,GO:0048584,GO:0048731,GO:0048856,GO:0048869,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050880,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051480,GO:0051481,GO:0051716,GO:0051937,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0060255,GO:0060627,GO:0065007,GO:0065008,GO:0070555,GO:0070887,GO:0071310,GO:0071345,GO:0071347,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072503,GO:0072507,GO:0080090,GO:0090066,GO:0090153,GO:0090154,GO:0090493,GO:0090494,GO:0097164,GO:0097746,GO:0097756,GO:0098771,GO:0098791,GO:1901222,GO:1901224,GO:1901564,GO:1901565,GO:1901575,GO:1902531,GO:1902533,GO:1903426,GO:1903428,GO:1903530,GO:1903532,GO:1903541,GO:1903543,GO:1904407,GO:1905038,GO:2000303,GO:2000304,GO:2000377,GO:2000379	3.1.4.12	ko:K12352	ko00600,ko01100,map00600,map01100	-	R02541	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	Exo_endo_phos
CMS2_k127_4240406_7	1273538.G159_17030	1.7e-80	276.0	COG3332@1|root,COG3332@2|Bacteria,1UYHE@1239|Firmicutes,4HCA1@91061|Bacilli,26EQ7@186818|Planococcaceae	91061|Bacilli	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
CMS2_k127_4240406_0	945713.IALB_2868	8.349e-267	827.0	COG2986@1|root,COG2986@2|Bacteria	2|Bacteria	E	ammonia-lyase activity	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
CMS2_k127_4240406_22	1232437.KL662020_gene805	2.415e-23	105.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1R4E8@1224|Proteobacteria,42Q65@68525|delta/epsilon subdivisions,2WMAM@28221|Deltaproteobacteria,2MHQ5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg
CMS2_k127_4240406_8	945713.IALB_0235	1.417e-73	253.0	COG1238@1|root,COG1238@2|Bacteria	2|Bacteria	I	metal cluster binding	MA20_20865	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	SNARE_assoc
CMS2_k127_4240406_16	398767.Glov_1087	6.143e-46	175.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2WMUX@28221|Deltaproteobacteria,43T33@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
CMS2_k127_4240406_30	1232410.KI421413_gene670	1.15e-06	55.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,42V1F@68525|delta/epsilon subdivisions,2WR79@28221|Deltaproteobacteria,43SR6@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
CMS2_k127_4240406_11	1047013.AQSP01000111_gene1674	1.254e-66	239.0	COG0859@1|root,COG0859@2|Bacteria,2NPXQ@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	rfaF	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527,ko:K02841,ko:K02843,ko:K12982	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30,GT9	-	Glyco_transf_9
CMS2_k127_4240406_21	1047013.AQSP01000111_gene1675	1.774e-24	109.0	COG2020@1|root,COG2020@2|Bacteria,2NS0J@2323|unclassified Bacteria	2|Bacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CMS2_k127_4240406_25	1042376.AFPK01000002_gene1795	1.595e-14	83.0	28KDN@1|root,2ZA04@2|Bacteria,4NJ9D@976|Bacteroidetes,1I0MI@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4240406_9	1499967.BAYZ01000050_gene2877	5.034e-72	249.0	COG0785@1|root,COG0785@2|Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
CMS2_k127_4240406_18	1304885.AUEY01000001_gene3204	4.377e-30	125.0	2DPAK@1|root,33193@2|Bacteria,1NDU6@1224|Proteobacteria,432ZD@68525|delta/epsilon subdivisions,2WYIN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4240406_13	290397.Adeh_3382	7.429e-56	218.0	COG3850@1|root,COG3850@2|Bacteria,1N013@1224|Proteobacteria,42Z7D@68525|delta/epsilon subdivisions,2WURU@28221|Deltaproteobacteria	1224|Proteobacteria	T	Double sensory domain of two-component sensor kinase	-	-	-	-	-	-	-	-	-	-	-	-	dCache_3
CMS2_k127_4240406_17	696281.Desru_3125	6.394e-44	181.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1TQ8G@1239|Firmicutes,24IMT@186801|Clostridia,2651V@186807|Peptococcaceae	186801|Clostridia	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
CMS2_k127_4240406_4	696281.Desru_0813	1.891e-148	484.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24D5G@186801|Clostridia,264AW@186807|Peptococcaceae	186801|Clostridia	T	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_4240406_6	1380394.JADL01000012_gene856	8.824e-129	443.0	28JZQ@1|root,2Z9PN@2|Bacteria,1N2WN@1224|Proteobacteria,2U0QD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4240406_28	211165.AJLN01000088_gene2613	1.697e-10	75.0	COG1680@1|root,COG1680@2|Bacteria,1G459@1117|Cyanobacteria,1JKYQ@1189|Stigonemataceae	1117|Cyanobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_4240406_24	177439.DP2721	1.815e-15	81.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MI1N@213118|Desulfobacterales	28221|Deltaproteobacteria	T	sigma-54 factor interaction domain-containing protein	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_4240406_15	1382359.JIAL01000001_gene327	5.23e-46	179.0	COG3005@1|root,COG3005@2|Bacteria,3Y4BJ@57723|Acidobacteria,2JJ2B@204432|Acidobacteriia	204432|Acidobacteriia	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS2_k127_4240406_31	1340493.JNIF01000003_gene1663	1.271e-06	61.0	28MCK@1|root,2ZAQP@2|Bacteria,3Y41I@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4240406_26	502025.Hoch_6274	2.516e-13	74.0	COG5492@1|root,COG5492@2|Bacteria,1MZ1W@1224|Proteobacteria	1224|Proteobacteria	C	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
CMS2_k127_4249105_0	1274524.BSONL12_21779	2.228e-192	625.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_4249974_0	1173023.KE650771_gene5201	4.774e-271	859.0	COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,Thioesterase,ketoacyl-synt
CMS2_k127_4250495_28	1492737.FEM08_20920	5.15e-17	82.0	COG0454@1|root,COG0456@2|Bacteria,4NFWE@976|Bacteroidetes,1HX0Z@117743|Flavobacteriia,2NU3Z@237|Flavobacterium	976|Bacteroidetes	K	GTP cyclohydrolase	yghO	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_4250495_12	999419.HMPREF1077_01415	3.427e-87	297.0	COG0454@1|root,COG0456@2|Bacteria,4NFWE@976|Bacteroidetes,2FNG4@200643|Bacteroidia,22WRZ@171551|Porphyromonadaceae	976|Bacteroidetes	K	Psort location Cytoplasmic, score 8.96	yghO	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_4250495_11	1408424.JHYI01000029_gene3969	9.652e-89	312.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,4HBDB@91061|Bacilli,1ZCGR@1386|Bacillus	91061|Bacilli	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4309,Glyco_hydro_3,Glyco_hydro_3_C
CMS2_k127_4250495_5	1123368.AUIS01000017_gene2588	3.722e-188	605.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,2NDZ8@225057|Acidithiobacillales	225057|Acidithiobacillales	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
CMS2_k127_4250495_18	574087.Acear_2003	6.881e-62	217.0	COG2391@1|root,COG2391@2|Bacteria,1VDTV@1239|Firmicutes,24QRU@186801|Clostridia,3WBYY@53433|Halanaerobiales	186801|Clostridia	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
CMS2_k127_4250495_19	243231.GSU2311	3.444e-61	216.0	COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,42QRV@68525|delta/epsilon subdivisions,2WMUE@28221|Deltaproteobacteria,43V97@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
CMS2_k127_4250495_27	1047013.AQSP01000139_gene2408	3.073e-20	102.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
CMS2_k127_4250495_24	1047013.AQSP01000139_gene2410	1.11e-32	134.0	COG1595@1|root,COG1595@2|Bacteria,2NPRC@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_4250495_33	1341155.FSS13T_06080	0.0004795	50.0	COG2834@1|root,COG2834@2|Bacteria,4NPWE@976|Bacteroidetes,1I2A3@117743|Flavobacteriia,2NV7Z@237|Flavobacterium	976|Bacteroidetes	M	Cell envelope biogenesis protein LolA	-	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
CMS2_k127_4250495_6	1211115.ALIQ01000175_gene3644	6.044e-159	511.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2TRB4@28211|Alphaproteobacteria,3NA95@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
CMS2_k127_4250495_25	1347087.CBYO010000014_gene2287	2.213e-32	133.0	COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,4HBXZ@91061|Bacilli	91061|Bacilli	D	Necessary for normal cell division and for the maintenance of normal septation	engB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
CMS2_k127_4250495_1	1382359.JIAL01000001_gene2863	1.125e-217	700.0	COG0466@1|root,COG0466@2|Bacteria,3Y3DI@57723|Acidobacteria,2JIB4@204432|Acidobacteriia	204432|Acidobacteriia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
CMS2_k127_4250495_7	634956.Geoth_0988	2.111e-140	460.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,4H9U4@91061|Bacilli,1WEH4@129337|Geobacillus	91061|Bacilli	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
CMS2_k127_4250495_14	1313265.JNIE01000002_gene825	4.295e-83	280.0	COG0740@1|root,COG0740@2|Bacteria,2G3IM@200783|Aquificae	200783|Aquificae	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
CMS2_k127_4250495_26	1379698.RBG1_1C00001G1716	3.909e-32	142.0	COG0544@1|root,COG0544@2|Bacteria,2NPBN@2323|unclassified Bacteria	2|Bacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
CMS2_k127_4250495_16	1121324.CLIT_11c02400	1.798e-64	232.0	COG0196@1|root,COG0196@2|Bacteria,1TPKS@1239|Firmicutes,2484A@186801|Clostridia,25QRH@186804|Peptostreptococcaceae	186801|Clostridia	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
CMS2_k127_4250495_22	1242864.D187_004746	3.886e-35	147.0	COG0457@1|root,COG0457@2|Bacteria,1R64F@1224|Proteobacteria,42Q6D@68525|delta/epsilon subdivisions,2WKT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
CMS2_k127_4250495_30	667014.Thein_1529	1.793e-08	58.0	2EAFJ@1|root,334IY@2|Bacteria,2GHZR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
CMS2_k127_4250495_15	639282.DEFDS_1789	8.717e-70	244.0	COG1694@1|root,COG3956@2|Bacteria,2GF4N@200930|Deferribacteres	200930|Deferribacteres	S	Phosphoribosyl-ATP pyrophosphohydrolase	-	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG
CMS2_k127_4250495_29	944479.JQLX01000011_gene825	2.477e-10	63.0	COG1487@1|root,COG1487@2|Bacteria,1MZB6@1224|Proteobacteria,42UNH@68525|delta/epsilon subdivisions,2WQQJ@28221|Deltaproteobacteria,2M7NG@213113|Desulfurellales	28221|Deltaproteobacteria	S	PIN domain	vapC	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
CMS2_k127_4250495_31	760142.Hipma_1650	9.578e-08	55.0	COG1672@1|root,COG1672@2|Bacteria,1N4VD@1224|Proteobacteria,42Y71@68525|delta/epsilon subdivisions,2WTK1@28221|Deltaproteobacteria,2M7JA@213113|Desulfurellales	28221|Deltaproteobacteria	S	Predicted AAA-ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,PDDEXK_9
CMS2_k127_4250495_9	484019.THA_987	3.604e-107	359.0	COG1672@1|root,COG1672@2|Bacteria,2GDSG@200918|Thermotogae	200918|Thermotogae	S	Predicted AAA-ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,PDDEXK_9
CMS2_k127_4250495_8	870187.Thini_4326	1.616e-128	430.0	COG1672@1|root,COG1672@2|Bacteria,1N4VD@1224|Proteobacteria,1RXZT@1236|Gammaproteobacteria,4620N@72273|Thiotrichales	1236|Gammaproteobacteria	S	InterPro IPR018631 IPR012547	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,PDDEXK_9
CMS2_k127_4250495_0	909663.KI867150_gene381	1.169e-278	872.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MRD4@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
CMS2_k127_4250495_4	1232410.KI421423_gene1871	2.544e-198	624.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,42NFZ@68525|delta/epsilon subdivisions,2WMBX@28221|Deltaproteobacteria,43UG9@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
CMS2_k127_4250495_10	443144.GM21_2868	6.101e-103	340.0	COG1924@1|root,COG1924@2|Bacteria,1RDZA@1224|Proteobacteria,42RYS@68525|delta/epsilon subdivisions,2WNJX@28221|Deltaproteobacteria,43T2B@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
CMS2_k127_4250495_20	1232410.KI421419_gene2454	1.382e-60	221.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,42QZK@68525|delta/epsilon subdivisions,2WMZB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
CMS2_k127_4250495_13	357809.Cphy_3574	5.223e-84	295.0	COG1032@1|root,COG1032@2|Bacteria,1W799@1239|Firmicutes,258NB@186801|Clostridia,22308@1506553|Lachnoclostridium	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_4250495_3	1191523.MROS_0118	3.015e-199	679.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	ko:K16923	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.28	-	-	HATPase_c,HTH_18,HisKA,PAS_4,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_4250495_21	391596.PBAL39_20344	5.45e-48	200.0	COG0745@1|root,COG0745@2|Bacteria,4P071@976|Bacteroidetes,1IVTF@117747|Sphingobacteriia	976|Bacteroidetes	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
CMS2_k127_4250495_2	1380600.AUYN01000001_gene2892	2.461e-200	674.0	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,1HXUN@117743|Flavobacteriia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_4250495_17	305900.GV64_16590	3.687e-63	238.0	COG0726@1|root,COG2911@1|root,COG2931@1|root,COG3291@1|root,COG3533@1|root,COG4719@1|root,COG4733@1|root,COG4932@1|root,COG5184@1|root,COG5434@1|root,COG0726@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,COG3533@2|Bacteria,COG4719@2|Bacteria,COG4733@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,COG5434@2|Bacteria,1QYMC@1224|Proteobacteria,1T3SC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	MQ	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS2_k127_4250495_23	694427.Palpr_2226	3.772e-33	147.0	COG3656@1|root,COG3656@2|Bacteria,4NHDQ@976|Bacteroidetes,2FTSH@200643|Bacteroidia,22Y91@171551|Porphyromonadaceae	976|Bacteroidetes	S	Fibronectin type 3 domain	-	-	-	ko:K21571	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_4257281_19	324925.Ppha_2425	5.197e-21	103.0	2E9II@1|root,333RI@2|Bacteria,1FEZP@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4257281_17	290512.Paes_2210	1.619e-22	107.0	2EDYH@1|root,337TB@2|Bacteria,1FEFX@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4257281_8	304371.MCP_1515	2.856e-47	185.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,2N91M@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
CMS2_k127_4257281_7	1047013.AQSP01000095_gene2303	1.811e-56	203.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_4257281_24	1234595.C725_1359	0.0006373	44.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,2U1KH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_4257281_5	880073.Calab_1282	2.779e-70	241.0	COG1443@1|root,COG1443@2|Bacteria,2NQ8N@2323|unclassified Bacteria	2|Bacteria	I	NUDIX domain	idi	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
CMS2_k127_4257281_1	330214.NIDE1041	4.027e-157	510.0	COG2317@1|root,COG2317@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	ypwA	GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.17.19	ko:K01299,ko:K03281	-	-	-	-	ko00000,ko01000,ko01002	2.A.49	-	-	Peptidase_M32
CMS2_k127_4257281_9	1198232.CYCME_1768	1.802e-43	177.0	COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,1MU1B@1224|Proteobacteria,1SYHX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	reductase chain B	-	-	-	ko:K07307	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko02000	5.A.3.3	-	-	DmsC,Fer4_11,Fer4_4
CMS2_k127_4257281_2	857293.CAAU_2006	2.909e-144	482.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,36E8E@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS2_k127_4257281_3	1173020.Cha6605_1137	1.451e-110	375.0	COG1233@1|root,COG1233@2|Bacteria,1GCDS@1117|Cyanobacteria	1117|Cyanobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
CMS2_k127_4257281_14	247490.KSU1_B0196	1.007e-23	108.0	COG4798@1|root,COG4798@2|Bacteria,2J4ZF@203682|Planctomycetes	203682|Planctomycetes	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
CMS2_k127_4257281_4	1121447.JONL01000008_gene3599	3.544e-74	268.0	COG1409@1|root,COG1409@2|Bacteria,1RK5B@1224|Proteobacteria,4306X@68525|delta/epsilon subdivisions,2WVEP@28221|Deltaproteobacteria,2M9PV@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_4257281_25	1047013.AQSP01000112_gene373	0.0008914	51.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,TolB_like
CMS2_k127_4257281_10	1033737.CAEV01000024_gene3524	3.123e-40	168.0	COG0641@1|root,COG0641@2|Bacteria,1TT6S@1239|Firmicutes,248QW@186801|Clostridia,36FP9@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
CMS2_k127_4257281_21	1047013.AQSP01000132_gene1742	2.493e-13	81.0	COG3391@1|root,COG3391@2|Bacteria,2NQ4G@2323|unclassified Bacteria	2|Bacteria	O	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,NHL,TolB_like
CMS2_k127_4257281_18	324925.Ppha_2424	8.496e-22	104.0	2EDYH@1|root,337TB@2|Bacteria,1FEFX@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4257281_11	871968.DESME_02275	2.526e-28	115.0	COG2161@1|root,COG2161@2|Bacteria,1V7IT@1239|Firmicutes,24MJ6@186801|Clostridia,262X2@186807|Peptococcaceae	186801|Clostridia	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
CMS2_k127_4257281_12	373903.Hore_13720	1.005e-25	109.0	COG3668@1|root,COG3668@2|Bacteria,1VECN@1239|Firmicutes,24Q4I@186801|Clostridia	186801|Clostridia	S	addiction module toxin, RelE StbE family	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
CMS2_k127_4257281_13	1121472.AQWN01000007_gene1058	9.978e-25	108.0	COG1569@1|root,COG1569@2|Bacteria,1VHAV@1239|Firmicutes,24QPU@186801|Clostridia,2671I@186807|Peptococcaceae	186801|Clostridia	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
CMS2_k127_4257281_20	933262.AXAM01000011_gene1786	3.344e-19	89.0	COG0864@1|root,COG0864@2|Bacteria	2|Bacteria	K	response to nickel cation	ndoAI	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K07723	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	RHH_1
CMS2_k127_4257281_23	1123313.ATUT01000023_gene503	1.244e-07	54.0	COG1373@1|root,COG1373@2|Bacteria,1TQ8Z@1239|Firmicutes,3VP3I@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
CMS2_k127_4257281_22	478741.JAFS01000001_gene1654	3.916e-08	61.0	2ECCV@1|root,336B4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204
CMS2_k127_4257281_15	324925.Ppha_2425	3.49e-23	110.0	2E9II@1|root,333RI@2|Bacteria,1FEZP@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4257281_16	290512.Paes_2210	1.191e-22	107.0	2EDYH@1|root,337TB@2|Bacteria,1FEFX@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4257281_0	1237149.C900_05793	3.004e-271	872.0	COG1680@1|root,COG4615@1|root,COG1680@2|Bacteria,COG4615@2|Bacteria,4NJ17@976|Bacteroidetes	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,Beta-lactamase
CMS2_k127_4262860_1	1196323.ALKF01000205_gene4114	0.0	1355.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4262860_2	1173024.KI912151_gene2451	0.0	1094.0	COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4262860_0	1121121.KB894307_gene2066	0.0	2511.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4262860_3	1123371.ATXH01000050_gene2026	2.255e-63	230.0	COG5464@1|root,COG5464@2|Bacteria	2|Bacteria	S	double-stranded DNA endodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
CMS2_k127_4272325_2	1345695.CLSA_c37640	3.977e-293	952.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36QT1@31979|Clostridiaceae	186801|Clostridia	Q	Phosphopantetheine attachment site	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_31,NAD_binding_4,PP-binding
CMS2_k127_4272325_3	1007103.AFHW01000205_gene5501	3.136e-65	256.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes	1239|Firmicutes	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4272325_1	1042163.BRLA_c024600	0.0	1067.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding
CMS2_k127_4272325_0	573061.Clocel_2482	0.0	3699.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4275796_1	1196323.ALKF01000125_gene4700	8.97e-311	997.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_4275796_0	1121121.KB894307_gene2066	0.0	1753.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4275796_2	1121904.ARBP01000015_gene179	5.492e-230	737.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47NTJ@768503|Cytophagia	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_4275796_3	246969.TAM4_760	1.261e-89	312.0	COG1672@1|root,arCOG03166@2157|Archaea,2XTP2@28890|Euryarchaeota	28890|Euryarchaeota	S	ATPase, AAA superfamily	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2,DUF234,HTH_IclR
CMS2_k127_4275796_4	261292.Nit79A3_3402	2.053e-66	233.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,2VQN2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
CMS2_k127_4276031_0	1250278.JQNQ01000001_gene3148	2.241e-34	141.0	COG2819@1|root,COG2819@2|Bacteria,4NN8M@976|Bacteroidetes,1HZYT@117743|Flavobacteriia	976|Bacteroidetes	S	Putative esterase	-	-	-	ko:K07017	-	-	-	-	ko00000	-	-	-	Esterase
CMS2_k127_4278188_1	394503.Ccel_0862	0.0	2581.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13612	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_4278188_0	394503.Ccel_0862	0.0	2872.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13612	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_4278188_13	1121890.AUDO01000030_gene1018	3.477e-78	269.0	COG1192@1|root,COG1192@2|Bacteria,4NFEX@976|Bacteroidetes,1HXYG@117743|Flavobacteriia,2NYWA@237|Flavobacterium	976|Bacteroidetes	D	Cellulose biosynthesis protein BcsQ	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
CMS2_k127_4278188_11	909613.UO65_0924	2.022e-110	409.0	COG2898@1|root,COG3321@1|root,COG2898@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria,4E8NU@85010|Pseudonocardiales	201174|Actinobacteria	Q	COG3321 Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_4278188_7	44251.PDUR_14190	6.567e-261	906.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	pksL	-	-	ko:K13612,ko:K13613,ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	ADH_N,ADH_zinc_N,ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_4278188_3	102129.Lepto7375DRAFT_0420	0.0	2035.0	COG3321@1|root,COG3882@1|root,COG3321@2|Bacteria,COG3882@2|Bacteria,1FZXE@1117|Cyanobacteria	1117|Cyanobacteria	Q	Beta-ketoacyl synthase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_4278188_17	290402.Cbei_0690	1.136e-59	214.0	COG1533@1|root,COG1533@2|Bacteria,1UU63@1239|Firmicutes	1239|Firmicutes	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF1848,Radical_SAM
CMS2_k127_4278188_23	1122611.KB903949_gene6566	0.0004295	47.0	COG0236@1|root,COG0236@2|Bacteria,2IQ43@201174|Actinobacteria,4EK5T@85012|Streptosporangiales	201174|Actinobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006643,GO:0006644,GO:0006664,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009245,GO:0009247,GO:0009259,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0019637,GO:0019693,GO:0019752,GO:0019842,GO:0030312,GO:0031177,GO:0032787,GO:0033218,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046483,GO:0046493,GO:0048037,GO:0051186,GO:0051192,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072341,GO:0072521,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901360,GO:1901564,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CMS2_k127_4278188_6	1122947.FR7_1808	5.619e-311	970.0	COG0331@1|root,COG2070@1|root,COG0331@2|Bacteria,COG2070@2|Bacteria,1UG0E@1239|Firmicutes,4H74S@909932|Negativicutes	909932|Negativicutes	I	Acyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1
CMS2_k127_4278188_24	1123288.SOV_7c00110	0.0007745	42.0	COG3321@1|root,COG3321@2|Bacteria,1TRPC@1239|Firmicutes,4H6RW@909932|Negativicutes	909932|Negativicutes	Q	Acyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1
CMS2_k127_4278188_22	1266845.Q783_09930	5.657e-15	81.0	COG2207@1|root,COG2207@2|Bacteria,1V28B@1239|Firmicutes,4IPWT@91061|Bacilli,27G76@186828|Carnobacteriaceae	91061|Bacilli	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC
CMS2_k127_4278188_18	768710.DesyoDRAFT_1472	1.311e-58	212.0	COG0437@1|root,COG0437@2|Bacteria,1TT2G@1239|Firmicutes,24DAZ@186801|Clostridia,261IB@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM formate dehydrogenase, beta subunit, Fe-S containing	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4,Fer4_7,Form-deh_trans
CMS2_k127_4278188_5	316067.Geob_1634	0.0	1119.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,43TK1@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
CMS2_k127_4278188_16	795359.TOPB45_0497	5.157e-68	235.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,2GGUA@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS2_k127_4278188_21	635013.TherJR_0773	1.811e-28	126.0	COG3058@1|root,COG3058@2|Bacteria,1VD22@1239|Firmicutes,25DKA@186801|Clostridia	186801|Clostridia	C	Necessary for formate dehydrogenase activity	-	-	-	ko:K02380	-	-	-	-	ko00000	-	-	-	FdhE
CMS2_k127_4278188_8	1499967.BAYZ01000103_gene3735	1.222e-131	427.0	COG0709@1|root,COG0709@2|Bacteria,2NNUD@2323|unclassified Bacteria	2|Bacteria	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C,Pyr_redox_2
CMS2_k127_4278188_10	269799.Gmet_3415	1.487e-114	395.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,43TPN@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Elongation factor SelB winged helix 3	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
CMS2_k127_4278188_20	1232437.KL662018_gene593	2.767e-44	171.0	COG0860@1|root,COG0860@2|Bacteria,1N0FW@1224|Proteobacteria,42VQ0@68525|delta/epsilon subdivisions	1224|Proteobacteria	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
CMS2_k127_4278188_19	244581.IM40_05235	1.538e-53	198.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2TS88@28211|Alphaproteobacteria,47F6Y@766|Rickettsiales	766|Rickettsiales	L	COG0084 Mg-dependent DNase	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
CMS2_k127_4278188_9	768706.Desor_2838	5.295e-128	424.0	COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,261E0@186807|Peptococcaceae	186801|Clostridia	E	Sodium:alanine symporter family	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
CMS2_k127_4278188_14	1117647.M5M_01075	1.226e-71	269.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RWRX@1236|Gammaproteobacteria,1J6C2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase
CMS2_k127_4278188_2	1121121.KB894288_gene2764	0.0	2181.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4278188_4	1121121.KB894288_gene2765	0.0	1696.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_4278188_15	509191.AEDB02000067_gene917	2.353e-70	251.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WNP0@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4279754_1	481448.Minf_2068	1.685e-83	285.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	yxbB	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
CMS2_k127_4279754_0	926560.KE387027_gene881	4.581e-127	413.0	COG0031@1|root,COG0031@2|Bacteria,1WJ3S@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_4280607_33	375286.mma_0799	3.862e-17	89.0	COG0457@1|root,COG1409@1|root,COG0457@2|Bacteria,COG1409@2|Bacteria,1PFH9@1224|Proteobacteria,2W1YZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4280607_21	1499967.BAYZ01000157_gene592	3.09e-40	153.0	2DP2F@1|root,3308W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4280607_30	1499967.BAYZ01000157_gene591	1.529e-18	89.0	2DTY1@1|root,33N5T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4280607_20	1304888.ATWF01000001_gene1792	2.93e-40	153.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_4280607_11	1047013.AQSP01000104_gene1416	1.122e-100	334.0	COG1136@1|root,COG1136@2|Bacteria	2|Bacteria	V	lipoprotein transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS2_k127_4280607_37	1047013.AQSP01000142_gene124	4.7e-09	68.0	COG3391@1|root,COG3391@2|Bacteria,2NQ4G@2323|unclassified Bacteria	2|Bacteria	O	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,NHL,TolB_like
CMS2_k127_4280607_6	1121957.ATVL01000011_gene3618	6.235e-193	627.0	COG0793@1|root,COG0793@2|Bacteria,4NEK8@976|Bacteroidetes,47MAF@768503|Cytophagia	976|Bacteroidetes	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
CMS2_k127_4280607_15	1121440.AUMA01000009_gene577	4.613e-69	252.0	COG2203@1|root,COG2203@2|Bacteria,1R73W@1224|Proteobacteria,42PQ8@68525|delta/epsilon subdivisions,2WIKB@28221|Deltaproteobacteria,2MARH@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Gaf domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS
CMS2_k127_4280607_5	880073.Calab_0801	5.647e-203	654.0	COG3591@1|root,COG3591@2|Bacteria,2NQEJ@2323|unclassified Bacteria	2|Bacteria	E	Peptidase S46	-	GO:0003674,GO:0003824,GO:0004177,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008239,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
CMS2_k127_4280607_25	880073.Calab_3408	4.167e-24	108.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Cytochrome_C554,DUF11,SLH
CMS2_k127_4280607_3	1047013.AQSP01000070_gene34	6.201e-240	784.0	COG3292@1|root,COG3920@1|root,COG3292@2|Bacteria,COG3920@2|Bacteria,2NNZT@2323|unclassified Bacteria	2|Bacteria	T	Two component regulator propeller	pdtaS	-	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,Reg_prop,Y_Y_Y
CMS2_k127_4280607_17	1167006.UWK_00732	2.704e-51	210.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MPMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
CMS2_k127_4280607_12	1499967.BAYZ01000194_gene3127	3.975e-99	328.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
CMS2_k127_4280607_14	243231.GSU2533	1.603e-77	274.0	COG3203@1|root,COG3203@2|Bacteria,1PJNW@1224|Proteobacteria,42TCM@68525|delta/epsilon subdivisions,2WPPQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4280607_34	243231.GSU2532	1.097e-16	85.0	COG0226@1|root,COG0226@2|Bacteria,1N19C@1224|Proteobacteria,42VP7@68525|delta/epsilon subdivisions,2WSZW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	COG0226 ABC-type phosphate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4280607_39	665952.HMPREF1015_00788	3.331e-07	63.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,1ZBBU@1386|Bacillus	91061|Bacilli	KLT	serine threonine protein kinase	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_4280607_35	194439.CT1115	6.733e-10	71.0	COG2159@1|root,COG2159@2|Bacteria,1FFN5@1090|Chlorobi	1090|Chlorobi	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
CMS2_k127_4280607_40	234267.Acid_2818	1.305e-06	57.0	2EPXQ@1|root,33HI8@2|Bacteria,3Y5ZD@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4280607_31	1499967.BAYZ01000153_gene1548	4.391e-18	90.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_13,AAA_22,AAA_35,PDDEXK_9
CMS2_k127_4280607_32	761193.Runsl_2172	1.238e-17	84.0	COG1373@1|root,COG1373@2|Bacteria,4NHQG@976|Bacteroidetes,47NRX@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_4280607_1	485913.Krac_9719	1.753e-294	947.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2G7P2@200795|Chloroflexi	200795|Chloroflexi	KLT	SMART serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_16,TPR_2,TPR_8,WD40
CMS2_k127_4280607_4	1458462.JNLK01000001_gene1863	2.756e-230	755.0	COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,27IJP@186928|unclassified Lachnospiraceae	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CMS2_k127_4280607_8	204669.Acid345_4761	3.911e-132	436.0	COG0312@1|root,COG0312@2|Bacteria,3Y2TY@57723|Acidobacteria,2JI8B@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
CMS2_k127_4280607_16	330214.NIDE1515	3.952e-67	246.0	COG0312@1|root,COG0312@2|Bacteria,3J0P7@40117|Nitrospirae	40117|Nitrospirae	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
CMS2_k127_4280607_19	439235.Dalk_0513	7.061e-41	173.0	COG0664@1|root,COG1033@1|root,COG2199@1|root,COG0664@2|Bacteria,COG1033@2|Bacteria,COG2199@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MJQ7@213118|Desulfobacterales	28221|Deltaproteobacteria	K	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	GGDEF,LolA_like,MMPL,cNMP_binding
CMS2_k127_4280607_2	1191523.MROS_1680	8.719e-244	767.0	COG2936@1|root,COG2936@2|Bacteria	2|Bacteria	V	dipeptidyl-peptidase activity	cocE	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS2_k127_4280607_24	291985.CCSI01000005_gene1008	7.752e-29	125.0	COG2227@1|root,COG2227@2|Bacteria,1QTWG@1224|Proteobacteria,2TX57@28211|Alphaproteobacteria,2KEHA@204457|Sphingomonadales	204457|Sphingomonadales	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
CMS2_k127_4280607_0	1047013.AQSP01000107_gene2089	8.1e-307	1015.0	COG2911@1|root,COG4775@1|root,COG2911@2|Bacteria,COG4775@2|Bacteria,2NNNW@2323|unclassified Bacteria	2|Bacteria	M	Surface antigen	-	-	-	ko:K07277,ko:K09800	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	AsmA_2,Bac_surface_Ag,DUF748,POTRA,TamB
CMS2_k127_4280607_13	1237149.C900_05645	7.996e-93	314.0	COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,47UAQ@768503|Cytophagia	976|Bacteroidetes	P	Sodium/calcium exchanger protein	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS2_k127_4280607_23	1254432.SCE1572_07095	1.689e-29	130.0	28IX1@1|root,2Z8V3@2|Bacteria,1N0WD@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF2914)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2914
CMS2_k127_4280607_9	247490.KSU1_C0714	4.986e-130	471.0	COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes	203682|Planctomycetes	O	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
CMS2_k127_4280607_27	1408473.JHXO01000001_gene2158	1.597e-21	113.0	COG3656@1|root,COG3656@2|Bacteria,4NHDQ@976|Bacteroidetes,2FTSH@200643|Bacteroidia	976|Bacteroidetes	S	Fibronectin type 3 domain	-	-	-	ko:K21571	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_4280607_18	1137281.D778_02333	1.852e-43	186.0	COG4886@1|root,COG4886@2|Bacteria,4NI2K@976|Bacteroidetes,1I0CI@117743|Flavobacteriia	976|Bacteroidetes	G	PFAM Leucine Rich Repeat	-	-	-	-	-	-	-	-	-	-	-	-	LRRNT_2,LRR_1,LRR_6,LRR_8
CMS2_k127_4280607_7	1191523.MROS_2005	1.084e-160	571.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4280607_36	925775.XVE_3843	1.301e-09	68.0	2DB8R@1|root,2Z7SP@2|Bacteria,1MX0M@1224|Proteobacteria,1SI41@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4280607_28	331678.Cphamn1_1942	1.638e-21	95.0	2E4DR@1|root,32Z92@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4280607_38	331678.Cphamn1_1941	1.557e-08	57.0	2E46S@1|root,32Z2Q@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4280607_22	639030.JHVA01000001_gene2353	9.523e-40	166.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_4280607_10	933262.AXAM01000111_gene2441	3.131e-102	343.0	COG2865@1|root,COG2865@2|Bacteria,1PF1D@1224|Proteobacteria,42Y7A@68525|delta/epsilon subdivisions,2WUEQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2,HATPase_c_4
CMS2_k127_4280607_26	743299.Acife_0178	5.707e-24	102.0	COG2865@1|root,COG2865@2|Bacteria,1PF1D@1224|Proteobacteria,1S0GE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
CMS2_k127_4283226_2	765911.Thivi_3711	4.277e-49	186.0	COG4870@1|root,COG4870@2|Bacteria,1RJ0M@1224|Proteobacteria,1SES2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
CMS2_k127_4283226_0	1499967.BAYZ01000048_gene2693	1.746e-198	630.0	COG0488@1|root,COG0488@2|Bacteria	2|Bacteria	L	(ABC) transporter	-	-	-	ko:K15738,ko:K18231	ko02010,map02010	-	-	-	br01600,ko00000,ko00001,ko01504,ko02000	3.A.1.120.6,3.A.1.121.1,3.A.1.121.3	-	-	ABC_tran
CMS2_k127_4283226_3	1192034.CAP_6590	6.261e-47	192.0	2E0M7@1|root,32W6F@2|Bacteria,1NB9Z@1224|Proteobacteria,42W6T@68525|delta/epsilon subdivisions,2WSFF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4283226_1	439235.Dalk_0237	1.509e-106	373.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_428690_11	221288.JH992901_gene3912	1.126e-67	241.0	COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_428690_0	316274.Haur_3961	0.0	2064.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,2G68I@200795|Chloroflexi,3765Y@32061|Chloroflexia	2|Bacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_428690_3	98439.AJLL01000096_gene4134	0.0	1306.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_428690_2	1196323.ALKF01000205_gene4117	0.0	1315.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_428690_8	402777.KB235898_gene5716	1.37e-123	404.0	COG0604@1|root,COG1020@1|root,COG0604@2|Bacteria,COG1020@2|Bacteria,1GBN8@1117|Cyanobacteria	1117|Cyanobacteria	Q	PFAM Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,AMP-binding,AMP-binding_C,Condensation,Nitroreductase,PP-binding
CMS2_k127_428690_1	1178540.BA70_16980	0.0	1388.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HTBC@91061|Bacilli,1ZS7J@1386|Bacillus	91061|Bacilli	IQ	polyketide synthase	-	-	-	ko:K15661	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_428690_4	118005.AWNK01000004_gene1064	0.0	1211.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_428690_9	431943.CKL_2354	1.556e-88	311.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36QT1@31979|Clostridiaceae	186801|Clostridia	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_31,NAD_binding_4,PP-binding,ketoacyl-synt
CMS2_k127_428690_10	595460.RRSWK_00713	5.35e-85	308.0	COG4992@1|root,COG4992@2|Bacteria,2J1WI@203682|Planctomycetes	203682|Planctomycetes	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
CMS2_k127_428690_5	1237149.C900_05793	1.223e-261	841.0	COG1680@1|root,COG4615@1|root,COG1680@2|Bacteria,COG4615@2|Bacteria,4NJ17@976|Bacteroidetes	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,Beta-lactamase
CMS2_k127_428690_12	1333998.M2A_0707	1.989e-44	180.0	COG1680@1|root,COG1680@2|Bacteria,1RIYG@1224|Proteobacteria,2UC0Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_428690_7	1047013.AQSP01000114_gene680	9.426e-131	446.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_428690_6	1237149.C900_05793	4.025e-243	787.0	COG1680@1|root,COG4615@1|root,COG1680@2|Bacteria,COG4615@2|Bacteria,4NJ17@976|Bacteroidetes	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,Beta-lactamase
CMS2_k127_428690_13	1121403.AUCV01000073_gene1306	0.0001465	48.0	COG1345@1|root,COG1572@1|root,COG1345@2|Bacteria,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	ko:K02396,ko:K13276	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02035,ko03110	-	-	-	Flg_bbr_C,Peptidase_S8,TMP_2,VCBS
CMS2_k127_4287289_8	204669.Acid345_1588	1.165e-125	418.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria,2JKV3@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_4287289_16	1121434.AULY01000006_gene348	3.106e-34	140.0	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,42UW6@68525|delta/epsilon subdivisions,2WQ4A@28221|Deltaproteobacteria,2MC4T@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
CMS2_k127_4287289_6	477974.Daud_1116	4.29e-139	451.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia,2607Y@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA2	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
CMS2_k127_4287289_17	443144.GM21_1953	8.439e-31	138.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MRH@68525|delta/epsilon subdivisions,2WM8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase HAMP	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_3
CMS2_k127_4287289_25	693661.Arcve_1981	2.463e-08	66.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota,246Q1@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS2_k127_4287289_7	880073.Calab_1643	1.003e-136	448.0	COG0448@1|root,COG0448@2|Bacteria,2NPBS@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27,3.2.1.68	ko:K00975,ko:K01214	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948,R09995,R11261	RC00002	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	iJN678.agp,iSbBS512_1146.agp	NTP_transferase
CMS2_k127_4287289_13	880073.Calab_0099	2.604e-54	196.0	COG0231@1|root,COG0231@2|Bacteria,2NPID@2323|unclassified Bacteria	2|Bacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
CMS2_k127_4287289_15	525904.Tter_1099	8.37e-38	158.0	COG2856@1|root,COG2856@2|Bacteria,2NQY0@2323|unclassified Bacteria	2|Bacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4287289_0	768706.Desor_3008	0.0	1119.0	COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,1TW0W@1239|Firmicutes,248VM@186801|Clostridia,260VK@186807|Peptococcaceae	186801|Clostridia	G	Pyruvate phosphate dikinase, PEP pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
CMS2_k127_4287289_21	1121422.AUMW01000026_gene408	4.96e-17	87.0	COG1595@1|root,COG1595@2|Bacteria,1VANG@1239|Firmicutes,24APW@186801|Clostridia	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_4287289_18	1047013.AQSP01000078_gene2048	4.022e-21	103.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,TonB_C
CMS2_k127_4287289_24	211165.AJLN01000088_gene2613	4.446e-11	75.0	COG1680@1|root,COG1680@2|Bacteria,1G459@1117|Cyanobacteria,1JKYQ@1189|Stigonemataceae	1117|Cyanobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_4287289_22	1292034.OR37_03562	4.709e-13	81.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,2KF0Q@204458|Caulobacterales	204458|Caulobacterales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
CMS2_k127_4287289_3	489825.LYNGBM3L_43410	3.214e-150	491.0	COG1680@1|root,COG1680@2|Bacteria,1G7C0@1117|Cyanobacteria,1HD9W@1150|Oscillatoriales	1117|Cyanobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
CMS2_k127_4287289_5	477974.Daud_1393	6.734e-143	479.0	COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,26133@186807|Peptococcaceae	186801|Clostridia	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
CMS2_k127_4287289_11	1123229.AUBC01000014_gene2955	8.653e-70	272.0	COG0265@1|root,COG0265@2|Bacteria,1NVK0@1224|Proteobacteria,2US7T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4287289_20	1047013.AQSP01000137_gene552	2.264e-19	88.0	COG1145@1|root,COG1145@2|Bacteria,2NPVR@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	yfhL	-	-	ko:K03522,ko:K05337	-	-	-	-	ko00000,ko04147	-	-	-	Fer4,Fer4_7
CMS2_k127_4287289_19	1322246.BN4_11865	4.538e-20	95.0	COG1633@1|root,COG1633@2|Bacteria,1N997@1224|Proteobacteria,42VKE@68525|delta/epsilon subdivisions,2WRKQ@28221|Deltaproteobacteria,2MC42@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_4287289_2	1121921.KB898713_gene1714	5.699e-152	490.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	macB	-	-	ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	FtsX,MacB_PCD
CMS2_k127_4287289_10	392500.Swoo_1902	7.702e-76	270.0	COG0845@1|root,COG0845@2|Bacteria,1RCT0@1224|Proteobacteria,1S3AD@1236|Gammaproteobacteria,2QABY@267890|Shewanellaceae	1236|Gammaproteobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
CMS2_k127_4287289_12	326297.Sama_1470	1.207e-58	219.0	COG0845@1|root,COG0845@2|Bacteria,1R78S@1224|Proteobacteria,1S0GJ@1236|Gammaproteobacteria,2QA9F@267890|Shewanellaceae	1236|Gammaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3,HlyD_D23
CMS2_k127_4287289_14	1117315.AHCA01000001_gene2403	3.459e-41	168.0	COG0845@1|root,COG0845@2|Bacteria,1P5GT@1224|Proteobacteria,1S7A6@1236|Gammaproteobacteria,2Q1VA@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
CMS2_k127_4287289_9	401526.TcarDRAFT_1637	3.149e-84	287.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4H22T@909932|Negativicutes	909932|Negativicutes	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_4287289_1	521460.Athe_1403	2.185e-188	596.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,42ER3@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
CMS2_k127_4287289_4	945713.IALB_2444	4.747e-147	475.0	COG1703@1|root,COG1703@2|Bacteria	2|Bacteria	E	isobutyryl-CoA mutase activity	argK	GO:0003674,GO:0003824,GO:0003924,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
CMS2_k127_4287343_2	1211777.BN77_p30067	1.259e-42	162.0	COG1487@1|root,COG1487@2|Bacteria,1RCQ1@1224|Proteobacteria,2V1E4@28211|Alphaproteobacteria,4BEEI@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4411)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4411
CMS2_k127_4287343_1	1041147.AUFB01000013_gene198	3.349e-104	351.0	COG2856@1|root,COG2856@2|Bacteria,1PFUN@1224|Proteobacteria,2UDZS@28211|Alphaproteobacteria,4B81R@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	IrrE N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31,Peptidase_M78
CMS2_k127_4287343_0	1191523.MROS_0650	1.521e-106	362.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS2_k127_4287343_3	933262.AXAM01000095_gene2127	3.5e-35	143.0	COG2865@1|root,COG2865@2|Bacteria,1R4MD@1224|Proteobacteria,42RP5@68525|delta/epsilon subdivisions,2WNV2@28221|Deltaproteobacteria,2MNCQ@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Putative DNA-binding domain	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
CMS2_k127_4288281_0	641107.CDLVIII_0709	0.0	1438.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
CMS2_k127_4295830_1	247490.KSU1_B0540	7.47e-98	339.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,2IZEZ@203682|Planctomycetes	203682|Planctomycetes	S	Memo-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1,Memo
CMS2_k127_4295830_2	237368.SCABRO_02134	6.68e-89	303.0	COG2006@1|root,COG2006@2|Bacteria,2IZN7@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS2_k127_4295830_0	237368.SCABRO_03950	3.112e-134	438.0	COG1180@1|root,COG1180@2|Bacteria,2IYWA@203682|Planctomycetes	203682|Planctomycetes	C	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
CMS2_k127_430452_0	1291050.JAGE01000002_gene3558	4.751e-214	693.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes	1239|Firmicutes	Q	synthase	-	-	-	ko:K13612,ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_4318702_4	509191.AEDB02000067_gene916	4.481e-198	632.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_4318702_0	641107.CDLVIII_0709	0.0	1562.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
CMS2_k127_4318702_5	509191.AEDB02000067_gene916	4.643e-197	630.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_4318702_2	394503.Ccel_2386	2.787e-229	784.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4318702_16	1123376.AUIU01000011_gene877	1.878e-44	189.0	COG0476@1|root,COG0476@2|Bacteria	2|Bacteria	H	Involved in molybdopterin and thiamine biosynthesis, family 2	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
CMS2_k127_4318702_18	1007103.AFHW01000032_gene2241	1.556e-37	166.0	COG3319@1|root,COG3319@2|Bacteria,1UUWT@1239|Firmicutes,4I7UA@91061|Bacilli,26XKF@186822|Paenibacillaceae	91061|Bacilli	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioesterase
CMS2_k127_4318702_17	326297.Sama_0384	2.315e-42	165.0	COG1506@1|root,COG1506@2|Bacteria,1QZ1F@1224|Proteobacteria	1224|Proteobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4318702_9	1033740.CAEW01000017_gene309	2.651e-101	337.0	COG0825@1|root,COG0825@2|Bacteria,1UHNS@1239|Firmicutes,4HA4C@91061|Bacilli,26DN4@186818|Planococcaceae	91061|Bacilli	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
CMS2_k127_4318702_11	642492.Clole_3046	3.04e-89	303.0	COG0777@1|root,COG0777@2|Bacteria,1TP4U@1239|Firmicutes,248QK@186801|Clostridia	186801|Clostridia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS20740	ACCA,Carboxyl_trans
CMS2_k127_4318702_6	398511.BpOF4_01540	2.442e-174	557.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,4HARK@91061|Bacilli,1ZC56@1386|Bacillus	91061|Bacilli	I	An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
CMS2_k127_4318702_19	317025.Tcr_0444	2.023e-29	123.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,460T1@72273|Thiotrichales	72273|Thiotrichales	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
CMS2_k127_4318702_8	1232410.KI421413_gene785	4.584e-119	390.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,42QKH@68525|delta/epsilon subdivisions,2WMW7@28221|Deltaproteobacteria,43UJV@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
CMS2_k127_4318702_15	931276.Cspa_c37570	1.765e-44	172.0	COG1266@1|root,COG1266@2|Bacteria,1VEJJ@1239|Firmicutes,24EDW@186801|Clostridia,36GT3@31979|Clostridiaceae	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
CMS2_k127_4318702_13	748449.Halha_2023	3.119e-61	223.0	COG1575@1|root,COG1575@2|Bacteria,1TSZV@1239|Firmicutes,24DJF@186801|Clostridia,3WBTB@53433|Halanaerobiales	186801|Clostridia	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iHN637.CLJU_RS19835	UbiA
CMS2_k127_4318702_7	909663.KI867150_gene410	3.221e-168	557.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MQVW@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
CMS2_k127_4318702_14	880073.Calab_2739	3.197e-51	185.0	COG2606@1|root,COG2606@2|Bacteria,2NPZ1@2323|unclassified Bacteria	2|Bacteria	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
CMS2_k127_4318702_12	1408422.JHYF01000006_gene1150	3.561e-79	280.0	28H5M@1|root,2Z7I7@2|Bacteria,1UC9R@1239|Firmicutes,248GH@186801|Clostridia,36F7I@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4318702_1	195253.Syn6312_0910	0.0	1089.0	COG4930@1|root,COG4930@2|Bacteria	2|Bacteria	O	Putative ATP-dependent Lon protease	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Dynamin_N,Lon_2,Lon_C,MIT_C
CMS2_k127_4318702_3	243231.GSU2106	1.691e-204	666.0	COG1524@1|root,COG1524@2|Bacteria,1MUYY@1224|Proteobacteria,42PS1@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	PFAM PglZ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PglZ
CMS2_k127_4318702_10	243231.GSU2107	1.668e-92	325.0	COG0286@1|root,COG1002@1|root,COG0286@2|Bacteria,COG1002@2|Bacteria,1NZDR@1224|Proteobacteria,42NKT@68525|delta/epsilon subdivisions,2WM7B@28221|Deltaproteobacteria,43U85@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	N-6 DNA Methylase	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I,N6_Mtase
CMS2_k127_432402_7	338963.Pcar_0294	2.05e-05	50.0	COG1409@1|root,COG5635@1|root,COG1409@2|Bacteria,COG5635@2|Bacteria,1QWD1@1224|Proteobacteria	1224|Proteobacteria	T	Heat shock 70 kDa protein	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,TIR_2
CMS2_k127_432402_5	1313421.JHBV01000042_gene3389	5.833e-114	381.0	COG2304@1|root,COG2304@2|Bacteria,4NEGD@976|Bacteroidetes,1IVER@117747|Sphingobacteriia	976|Bacteroidetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
CMS2_k127_432402_4	1313421.JHBV01000041_gene3629	4.42e-232	740.0	COG2304@1|root,COG2304@2|Bacteria,4NK2W@976|Bacteroidetes	976|Bacteroidetes	M	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	OmpA,VIT,VWA,VWA_3
CMS2_k127_432402_0	1144275.COCOR_03598	0.0	1986.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions,2X86Z@28221|Deltaproteobacteria,2Z3ME@29|Myxococcales	28221|Deltaproteobacteria	Q	Pfam:HxxPF_rpt	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_432402_3	118005.AWNK01000004_gene1064	3.475e-301	993.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_432402_2	118005.AWNK01000004_gene1064	0.0	1064.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_432402_6	398512.JQKC01000015_gene4647	4.326e-68	241.0	COG0345@1|root,COG0345@2|Bacteria,1UZ3D@1239|Firmicutes,24NRX@186801|Clostridia,3WPR1@541000|Ruminococcaceae	186801|Clostridia	E	Pyrroline-5-carboxylate reductase dimerisation	-	-	-	ko:K02239	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	F420_oxidored,P5CR_dimer
CMS2_k127_432402_1	1117108.PAALTS15_22598	0.0	1184.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4340802_1	649747.HMPREF0083_00279	0.0	2303.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16123,ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4340802_7	1123229.AUBC01000012_gene2735	3.588e-136	452.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,3JQP1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Domain of unknown function (DUF4070)	MA20_17485	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_4340802_0	1408422.JHYF01000017_gene1871	0.0	2893.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4340802_2	1121121.KB894307_gene2066	0.0	1439.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4340802_9	745718.JADT01000038_gene2491	1.01e-12	74.0	COG0384@1|root,COG0384@2|Bacteria,4NEWM@976|Bacteroidetes,1IISU@117743|Flavobacteriia	976|Bacteroidetes	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
CMS2_k127_4340802_5	509191.AEDB02000067_gene916	5.164e-186	597.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_4340802_3	1408422.JHYF01000017_gene1871	0.0	1139.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4340802_6	1121015.N789_06345	8.396e-149	498.0	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria,1X4WG@135614|Xanthomonadales	135614|Xanthomonadales	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_4340802_4	1237149.C900_04816	8.095e-223	741.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47TR0@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Response_reg,Y_Y_Y
CMS2_k127_4340802_8	1268237.G114_04133	3.639e-47	175.0	2EB53@1|root,3355S@2|Bacteria,1N5I5@1224|Proteobacteria,1SDYU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1842)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1842
CMS2_k127_4376227_20	1047013.AQSP01000114_gene698	6.233e-53	198.0	2CK1R@1|root,31E53@2|Bacteria,2NR8M@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4376227_3	869213.JCM21142_104430	1.034e-124	410.0	COG2223@1|root,COG2223@2|Bacteria,4PKPF@976|Bacteroidetes	976|Bacteroidetes	P	fosmidomycin resistance protein	fsr	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
CMS2_k127_4376227_17	373994.Riv7116_4628	1.153e-61	220.0	COG2340@1|root,COG2340@2|Bacteria,1G68A@1117|Cyanobacteria,1HKMA@1161|Nostocales	1117|Cyanobacteria	S	protein with SCP PR1 domains	-	-	-	-	-	-	-	-	-	-	-	-	CAP
CMS2_k127_4376227_18	1168034.FH5T_04120	2.797e-61	217.0	COG0518@1|root,COG0518@2|Bacteria,4P7ZK@976|Bacteroidetes	976|Bacteroidetes	F	Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
CMS2_k127_4376227_14	1499967.BAYZ01000019_gene6324	1.401e-74	258.0	28NH4@1|root,2ZBJ2@2|Bacteria,2NQY1@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4376227_4	1291050.JAGE01000001_gene2555	1.636e-123	408.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes	1239|Firmicutes	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_4376227_7	394503.Ccel_0972	6.32e-99	337.0	COG1819@1|root,COG1819@2|Bacteria,1TSPC@1239|Firmicutes,24D1S@186801|Clostridia,36ES5@31979|Clostridiaceae	186801|Clostridia	CG	TIGRFAM glycosyltransferase, MGT family	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
CMS2_k127_4376227_36	251221.35213621	0.0005279	53.0	COG1215@1|root,COG1215@2|Bacteria,1G2ZP@1117|Cyanobacteria	1117|Cyanobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_4376227_0	1408422.JHYF01000017_gene1871	0.0	2421.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4376227_35	926560.KE387027_gene330	1.466e-05	55.0	2ENAD@1|root,33FY3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4376227_26	1121403.AUCV01000020_gene3089	1.222e-28	130.0	COG0535@1|root,COG0535@2|Bacteria,1MZZI@1224|Proteobacteria	1224|Proteobacteria	S	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4376227_34	1229780.BN381_130153	7.168e-06	58.0	COG0500@1|root,COG2226@2|Bacteria,2IEI0@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,Methyltransf_11
CMS2_k127_4376227_31	1211814.CAPG01000082_gene3799	1.17e-14	75.0	2BF4Y@1|root,328X8@2|Bacteria,1UB8H@1239|Firmicutes,4IMM8@91061|Bacilli,1ZKEI@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4376227_9	378806.STAUR_7504	9.77e-87	319.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,1QUYA@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
CMS2_k127_4376227_28	1121007.AUML01000003_gene2527	4.518e-19	103.0	COG2207@1|root,COG2207@2|Bacteria,4NKKA@976|Bacteroidetes,1HX54@117743|Flavobacteriia,2YHTZ@290174|Aquimarina	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS2_k127_4376227_6	862908.BMS_1997	5.037e-102	349.0	COG0491@1|root,COG0494@1|root,COG0491@2|Bacteria,COG0494@2|Bacteria,1MVC3@1224|Proteobacteria,430H1@68525|delta/epsilon subdivisions,2WVZX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,NUDIX
CMS2_k127_4376227_37	378806.STAUR_4709	0.0009967	46.0	2BR3K@1|root,32K1I@2|Bacteria,1Q2KA@1224|Proteobacteria,43872@68525|delta/epsilon subdivisions,2X3GX@28221|Deltaproteobacteria,2YW1T@29|Myxococcales	28221|Deltaproteobacteria	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
CMS2_k127_4376227_5	489825.LYNGBM3L_00720	4.831e-120	402.0	COG1226@1|root,COG1226@2|Bacteria,1G2MJ@1117|Cyanobacteria,1H8TX@1150|Oscillatoriales	1117|Cyanobacteria	P	k transport	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,TrkA_N
CMS2_k127_4376227_1	1237149.C900_05793	1.79e-287	917.0	COG1680@1|root,COG4615@1|root,COG1680@2|Bacteria,COG4615@2|Bacteria,4NJ17@976|Bacteroidetes	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,Beta-lactamase
CMS2_k127_4376227_27	406124.ACPC01000014_gene883	1.298e-22	108.0	COG1372@1|root,COG1372@2|Bacteria,1VPYF@1239|Firmicutes,4HSTN@91061|Bacilli,1ZEPN@1386|Bacillus	91061|Bacilli	L	LAGLIDADG-like domain	-	-	-	-	-	-	-	-	-	-	-	-	LAGLIDADG_3
CMS2_k127_4376227_16	1047013.AQSP01000134_gene1379	3.162e-63	228.0	COG1475@1|root,COG1475@2|Bacteria	2|Bacteria	K	chromosome segregation	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
CMS2_k127_4376227_8	1047013.AQSP01000134_gene1378	5.293e-92	308.0	COG1192@1|root,COG1192@2|Bacteria,2NP2C@2323|unclassified Bacteria	2|Bacteria	D	Cobyrinic acid ac-diamide synthase	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS2_k127_4376227_29	1123242.JH636436_gene567	7.492e-17	88.0	COG0546@1|root,COG0546@2|Bacteria,2J0RU@203682|Planctomycetes	203682|Planctomycetes	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
CMS2_k127_4376227_10	1047013.AQSP01000139_gene2400	2.69e-84	297.0	COG1160@1|root,COG1160@2|Bacteria,2NNTW@2323|unclassified Bacteria	2|Bacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363	1.1.1.399,1.1.1.95	ko:K00058,ko:K03977	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko03009,ko04147	-	-	-	KH_dom-like,MMR_HSR1
CMS2_k127_4376227_21	1047013.AQSP01000138_gene1015	2.266e-47	175.0	COG0245@1|root,COG0245@2|Bacteria,2NPFV@2323|unclassified Bacteria	2|Bacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
CMS2_k127_4376227_11	1047013.AQSP01000138_gene1013	2.282e-83	288.0	COG4956@1|root,COG4956@2|Bacteria,2NP0D@2323|unclassified Bacteria	2|Bacteria	S	Large family of predicted nucleotide-binding domains	yacL	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	PIN,PIN_4,TRAM
CMS2_k127_4376227_13	1047013.AQSP01000099_gene1495	1.679e-77	267.0	COG0805@1|root,COG0805@2|Bacteria,2NPGB@2323|unclassified Bacteria	2|Bacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
CMS2_k127_4376227_30	1047013.AQSP01000099_gene1496	2.266e-16	81.0	COG1826@1|root,COG1826@2|Bacteria,2NQ3N@2323|unclassified Bacteria	2|Bacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116,ko:K03117,ko:K03646	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	2.A.64,2.C.1.2	-	-	MttA_Hcf106
CMS2_k127_4376227_12	1265503.KB905176_gene4099	9.54e-83	308.0	COG2199@1|root,COG3292@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1T2D4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,GGDEF,HATPase_c,HisKA,Response_reg
CMS2_k127_4376227_15	1131812.JQMS01000001_gene2484	8.98e-68	241.0	COG0053@1|root,COG0053@2|Bacteria,4NGDQ@976|Bacteroidetes,1I1F4@117743|Flavobacteriia,2NVDM@237|Flavobacterium	976|Bacteroidetes	P	cation transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
CMS2_k127_4376227_22	311424.DhcVS_1423	4.661e-40	171.0	COG1032@1|root,COG1032@2|Bacteria,2GAY6@200795|Chloroflexi,34DJV@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,PqqD,Radical_SAM
CMS2_k127_4376227_25	255470.cbdbA1620	1.748e-30	140.0	COG1032@1|root,COG1032@2|Bacteria,2GAY6@200795|Chloroflexi,34DJV@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,PqqD,Radical_SAM
CMS2_k127_4376227_23	255470.cbdbA1620	1.019e-38	166.0	COG1032@1|root,COG1032@2|Bacteria,2GAY6@200795|Chloroflexi,34DJV@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,PqqD,Radical_SAM
CMS2_k127_4376227_24	311424.DhcVS_1423	5.588e-38	164.0	COG1032@1|root,COG1032@2|Bacteria,2GAY6@200795|Chloroflexi,34DJV@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,PqqD,Radical_SAM
CMS2_k127_4376227_32	720554.Clocl_4084	1.273e-14	76.0	COG0236@1|root,COG0236@2|Bacteria,1W6C6@1239|Firmicutes,257IG@186801|Clostridia	186801|Clostridia	IQ	Phosphopantetheine attachment site	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CMS2_k127_4376227_2	203119.Cthe_2226	1.748e-176	568.0	COG3882@1|root,COG3882@2|Bacteria,1TTCC@1239|Firmicutes,24A4U@186801|Clostridia,3WHMQ@541000|Ruminococcaceae	186801|Clostridia	Q	HAD-superfamily phosphatase, subfamily IIIC	-	-	-	-	-	-	-	-	-	-	-	-	NIF
CMS2_k127_4376227_19	1235802.C823_02161	4.286e-53	199.0	COG1775@1|root,COG1775@2|Bacteria	2|Bacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
CMS2_k127_4376227_33	1235802.C823_02162	1.52e-11	66.0	COG1775@1|root,COG1775@2|Bacteria,1TS7H@1239|Firmicutes,2493U@186801|Clostridia,25XI6@186806|Eubacteriaceae	186801|Clostridia	E	2-hydroxyglutaryl-CoA dehydratase, D-component	fldB	-	1.3.7.8,4.2.1.157,4.2.1.167,4.2.1.54	ko:K04113,ko:K20025,ko:K20626,ko:K20903	ko00362,ko00640,ko00643,ko01100,ko01120,ko01220,map00362,map00640,map00643,map01100,map01120,map01220	M00541	R02451,R02963	RC00002,RC00818,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
CMS2_k127_4378051_58	1408324.JNJK01000008_gene1806	1.574e-05	53.0	COG1758@1|root,COG1758@2|Bacteria,1VF65@1239|Firmicutes,2584B@186801|Clostridia,27PKH@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	-	-	-	-	-	-	-	-	-	-	RNA_pol_Rpb6
CMS2_k127_4378051_32	269799.Gmet_2345	6.324e-58	215.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42NEW@68525|delta/epsilon subdivisions,2WJNJ@28221|Deltaproteobacteria,43S6D@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS2_k127_4378051_35	639282.DEFDS_0138	7.327e-38	149.0	COG0241@1|root,COG0241@2|Bacteria,2GFIZ@200930|Deferribacteres	200930|Deferribacteres	E	Polynucleotide kinase 3 phosphatase	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
CMS2_k127_4378051_12	880073.Calab_0508	6.169e-163	561.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_9,Response_reg
CMS2_k127_4378051_8	234267.Acid_2282	2.189e-192	611.0	COG1228@1|root,COG1228@2|Bacteria,3Y3PQ@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS2_k127_4378051_44	1120925.F941_00976	1.199e-24	118.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,1RQ67@1236|Gammaproteobacteria,3NJIY@468|Moraxellaceae	1236|Gammaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	mdtA	-	-	ko:K07799,ko:K21135	ko02020,map02020	M00648,M00822	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2.35,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS2_k127_4378051_2	1121930.AQXG01000001_gene1203	2.685e-257	827.0	COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS2_k127_4378051_5	237368.SCABRO_02347	9.554e-208	683.0	COG0841@1|root,COG0841@2|Bacteria,2IY6W@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS2_k127_4378051_50	1185876.BN8_02203	3.133e-18	88.0	2FBH3@1|root,343NG@2|Bacteria,4P60S@976|Bacteroidetes,47VSN@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4378051_4	1237149.C900_04816	4.217e-228	756.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47TR0@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Response_reg,Y_Y_Y
CMS2_k127_4378051_38	243232.MJ_1568	7.728e-30	126.0	COG1514@1|root,arCOG01736@2157|Archaea,2XZ2M@28890|Euryarchaeota,23R23@183939|Methanococci	183939|Methanococci	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
CMS2_k127_4378051_36	1047013.AQSP01000094_gene27	3.163e-36	144.0	COG0344@1|root,COG0344@2|Bacteria,2NPME@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
CMS2_k127_4378051_23	1047013.AQSP01000094_gene26	2.195e-83	288.0	COG0240@1|root,COG0240@2|Bacteria,2NP1N@2323|unclassified Bacteria	2|Bacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576	1.1.1.94	ko:K00057,ko:K07175	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	iIT341.HP0961,iJN678.gpsA,iJN746.PP_4169,iSFV_1184.SFV_3923	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
CMS2_k127_4378051_24	1469607.KK073768_gene1764	6.218e-82	292.0	COG1716@1|root,COG2114@1|root,COG2203@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,1G1FY@1117|Cyanobacteria,1HKTP@1161|Nostocales	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	cyaD	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,GAF,GAF_2,Guanylate_cyc
CMS2_k127_4378051_52	123214.PERMA_0798	8.065e-13	78.0	COG3063@1|root,COG3087@1|root,COG3063@2|Bacteria,COG3087@2|Bacteria,2G4AU@200783|Aquificae	200783|Aquificae	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	SPOR,TPR_2,TPR_6,TPR_8
CMS2_k127_4378051_33	1158609.I586_02481	3.428e-49	186.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,4HCDR@91061|Bacilli,4B0N0@81852|Enterococcaceae	91061|Bacilli	T	Sigma factor PP2C-like phosphatases	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
CMS2_k127_4378051_56	1117379.BABA_01255	2.65e-08	61.0	COG1716@1|root,COG1716@2|Bacteria,1V0I9@1239|Firmicutes,4HUF1@91061|Bacilli,1ZBM3@1386|Bacillus	91061|Bacilli	T	Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA
CMS2_k127_4378051_48	945713.IALB_3074	4.393e-19	93.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin,Thioredoxin_2,Thioredoxin_9
CMS2_k127_4378051_37	469381.Dpep_1457	4.7e-30	126.0	COG0801@1|root,COG1469@1|root,COG0801@2|Bacteria,COG1469@2|Bacteria,3TB8E@508458|Synergistetes	508458|Synergistetes	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	-	-	2.7.6.3,3.5.4.39	ko:K00950,ko:K17488	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R10348	RC00002,RC00017,RC02504,RC03131	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1,HPPK
CMS2_k127_4378051_53	1120953.AUBH01000005_gene2232	1.649e-12	76.0	COG3595@1|root,COG3595@2|Bacteria,1RFCY@1224|Proteobacteria,1S5RB@1236|Gammaproteobacteria,467PX@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS2_k127_4378051_26	945713.IALB_2137	9.406e-73	255.0	2AMSR@1|root,31CP7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4378051_29	1123252.ATZF01000007_gene233	3.177e-71	250.0	COG0639@1|root,COG0639@2|Bacteria,1V45T@1239|Firmicutes,4HHSG@91061|Bacilli	91061|Bacilli	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
CMS2_k127_4378051_6	742767.HMPREF9456_00067	3.863e-199	636.0	COG0513@1|root,COG0513@2|Bacteria,4NEJV@976|Bacteroidetes,2FMB6@200643|Bacteroidia,22W44@171551|Porphyromonadaceae	976|Bacteroidetes	L	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
CMS2_k127_4378051_15	1173024.KI912149_gene5228	1.576e-117	394.0	COG0464@1|root,COG0464@2|Bacteria,1G04V@1117|Cyanobacteria,1JJ89@1189|Stigonemataceae	1117|Cyanobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS2_k127_4378051_19	1047013.AQSP01000085_gene1983	3.08e-93	319.0	COG0763@1|root,COG0763@2|Bacteria,2NP10@2323|unclassified Bacteria	2|Bacteria	I	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
CMS2_k127_4378051_57	903818.KI912268_gene2498	5.193e-08	63.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02650	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	N_methyl,Pilin_GH,Pilin_PilA
CMS2_k127_4378051_43	228410.NE1602	7.456e-26	111.0	COG2165@1|root,COG2165@2|Bacteria,1N1QJ@1224|Proteobacteria,2VTYJ@28216|Betaproteobacteria,37385@32003|Nitrosomonadales	28216|Betaproteobacteria	U	PFAM type II secretion system protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_4378051_14	880073.Calab_0843	6.415e-142	460.0	COG0436@1|root,COG0436@2|Bacteria,2NP0E@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class I and II	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	iHN637.CLJU_RS10450	Aminotran_1_2
CMS2_k127_4378051_18	293826.Amet_0017	5.038e-100	335.0	COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,247IJ@186801|Clostridia,36E6G@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12020	NadA
CMS2_k127_4378051_51	665571.STHERM_c16720	1.212e-14	78.0	COG1734@1|root,COG1734@2|Bacteria,2J7Y1@203691|Spirochaetes	203691|Spirochaetes	T	Prokaryotic dksA traR C4-type zinc finger	dksA	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
CMS2_k127_4378051_55	1047013.AQSP01000144_gene847	6.969e-09	69.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	ko:K02847	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	TPR_8,Wzy_C
CMS2_k127_4378051_21	694431.DESACE_00185	6.765e-90	312.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria,2M7GH@213113|Desulfurellales	28221|Deltaproteobacteria	M	Bacterial sugar transferase	epsL	-	-	ko:K03606	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,CoA_binding_3
CMS2_k127_4378051_31	661478.OP10G_3363	7.341e-62	235.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	1.1.2.6,2.7.11.1	ko:K05889,ko:K12132	-	-	R03136	-	ko00000,ko01000,ko01001	-	-	-	Cytochrome_CBB3,DUF1863,PQQ,PQQ_2,PQQ_3,Pkinase
CMS2_k127_4378051_1	1047013.AQSP01000135_gene1619	3.229e-291	913.0	COG1205@1|root,COG1205@2|Bacteria,2NNKJ@2323|unclassified Bacteria	2|Bacteria	L	Domain of unknown function (DUF1998)	yprA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
CMS2_k127_4378051_11	1047013.AQSP01000111_gene1687	3.041e-173	561.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS2_k127_4378051_40	349161.Dred_2286	5.152e-29	123.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,262RV@186807|Peptococcaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_4378051_47	318464.IO99_07865	3.989e-19	92.0	COG1725@1|root,COG1725@2|Bacteria,1VA2B@1239|Firmicutes,24N57@186801|Clostridia,36KP5@31979|Clostridiaceae	186801|Clostridia	K	GntR family	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS2_k127_4378051_46	1232410.KI421413_gene698	6.442e-23	104.0	COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,42VMT@68525|delta/epsilon subdivisions,2WPFB@28221|Deltaproteobacteria,43V91@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	FxsA cytoplasmic membrane protein	fsxA	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
CMS2_k127_4378051_0	385682.AFSL01000014_gene2730	6.475e-317	987.0	COG0550@1|root,COG0550@2|Bacteria,4NF9S@976|Bacteroidetes,2FMSF@200643|Bacteroidia,3XINJ@558415|Marinilabiliaceae	976|Bacteroidetes	L	Bacterial DNA topoisomeraes I ATP-binding domain	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
CMS2_k127_4378051_7	1343739.PAP_06890	7.516e-199	631.0	COG0591@1|root,arCOG01316@2157|Archaea,2XU91@28890|Euryarchaeota,243HW@183968|Thermococci	183968|Thermococci	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307,ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21,2.A.21.2	-	-	SSF
CMS2_k127_4378051_49	1499967.BAYZ01000161_gene386	4.553e-19	102.0	COG3152@1|root,COG3152@2|Bacteria	2|Bacteria	L	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF805
CMS2_k127_4378051_54	377629.TERTU_0584	3.428e-10	73.0	COG3152@1|root,COG3152@2|Bacteria,1N85G@1224|Proteobacteria,1SCMI@1236|Gammaproteobacteria,2PNXP@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4378051_20	909663.KI867150_gene1702	3.657e-90	304.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,42P8N@68525|delta/epsilon subdivisions,2X2Q8@28221|Deltaproteobacteria,2MRMR@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS2_k127_4378051_17	909663.KI867150_gene1703	9.45e-109	362.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42PIH@68525|delta/epsilon subdivisions,2WJH2@28221|Deltaproteobacteria,2MRI5@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
CMS2_k127_4378051_28	909663.KI867150_gene1704	5.483e-72	252.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,42PQA@68525|delta/epsilon subdivisions,2WKNZ@28221|Deltaproteobacteria,2MR8B@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
CMS2_k127_4378051_9	1047013.AQSP01000081_gene88	2.851e-191	616.0	COG4206@1|root,COG4206@2|Bacteria,2NP6H@2323|unclassified Bacteria	2|Bacteria	H	TonB dependent receptor	btuB	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
CMS2_k127_4378051_3	545695.TREAZ_2148	8.499e-257	810.0	COG1523@1|root,COG1523@2|Bacteria,2J61K@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
CMS2_k127_4378051_22	1047013.AQSP01000121_gene2694	2.266e-86	309.0	COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_4378051_34	243274.THEMA_02135	2.808e-41	158.0	COG2110@1|root,COG2256@1|root,COG2110@2|Bacteria,COG2256@2|Bacteria,2GC7M@200918|Thermotogae	200918|Thermotogae	L	PFAM AAA ATPase central domain protein	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,Macro,MgsA_C,RuvB_N
CMS2_k127_4378051_13	1047013.AQSP01000063_gene1512	1.23e-146	476.0	COG0015@1|root,COG0015@2|Bacteria,2NP0M@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1095,iSB619.SA_RS09895	ADSL_C,Lyase_1
CMS2_k127_4378051_45	1121012.AUKX01000001_gene1196	3.137e-23	118.0	2BZ4R@1|root,3344Z@2|Bacteria,4NX0J@976|Bacteroidetes,1I7U3@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4378051_41	1280949.HAD_15797	1.508e-28	130.0	COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,2U98X@28211|Alphaproteobacteria,43ZRY@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate	cobP	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
CMS2_k127_4378051_16	161156.JQKW01000008_gene562	4.541e-111	369.0	COG2038@1|root,COG2038@2|Bacteria,2GH7M@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Phosphoribosyltransferase	-	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
CMS2_k127_4378051_39	1294142.CINTURNW_3183	3.327e-29	127.0	COG0368@1|root,COG0368@2|Bacteria,1V1QB@1239|Firmicutes,24I0D@186801|Clostridia,36H10@31979|Clostridiaceae	186801|Clostridia	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
CMS2_k127_4378051_30	289376.THEYE_A1181	6.242e-71	246.0	COG2102@1|root,COG2102@2|Bacteria	2|Bacteria	S	diphthine-ammonia ligase activity	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
CMS2_k127_4378051_10	880073.Calab_3349	1.859e-180	582.0	COG0457@1|root,COG0457@2|Bacteria	880073.Calab_3349|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4387415_0	1123257.AUFV01000008_gene517	7.982e-66	245.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria	1224|Proteobacteria	M	Capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
CMS2_k127_4387415_1	158189.SpiBuddy_2596	3.437e-59	208.0	COG2233@1|root,COG2233@2|Bacteria,2J5WY@203691|Spirochaetes	203691|Spirochaetes	F	Uracil permease	-	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
CMS2_k127_4395123_2	1267534.KB906756_gene485	0.0003718	44.0	COG0624@1|root,COG0624@2|Bacteria,3Y2UM@57723|Acidobacteria,2JKEA@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS2_k127_4395123_3	1283284.AZUK01000001_gene1275	0.000607	47.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1Y4ZN@135624|Aeromonadales	135624|Aeromonadales	KT	Bacterial regulatory protein, Fis family	-	-	-	ko:K11914	-	-	-	-	ko00000,ko02044,ko03000	-	-	-	HTH_8,Sigma54_activat
CMS2_k127_4395123_0	1307759.JOMJ01000003_gene1235	1.497e-49	187.0	COG3677@1|root,COG3677@2|Bacteria,1RFKN@1224|Proteobacteria,43B05@68525|delta/epsilon subdivisions,2X6E9@28221|Deltaproteobacteria,2MH20@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
CMS2_k127_4395123_1	1047013.AQSP01000123_gene1523	2.668e-13	72.0	COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria	2|Bacteria	P	COGs COG1629 Outer membrane receptor protein mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
CMS2_k127_439804_0	1121121.KB894288_gene2764	5.222e-153	510.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_439804_1	1051501.AYTL01000033_gene304	4.747e-57	224.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	ko:K15667,ko:K16122	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_4416631_8	926549.KI421517_gene1477	1.097e-05	56.0	COG0859@1|root,COG0859@2|Bacteria,4NIRT@976|Bacteroidetes,47MTI@768503|Cytophagia	976|Bacteroidetes	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS2_k127_4416631_7	1052684.PPM_4326	1.818e-12	78.0	COG0535@1|root,COG0535@2|Bacteria,1V5FE@1239|Firmicutes,4HSHA@91061|Bacilli,2707S@186822|Paenibacillaceae	91061|Bacilli	C	Iron-sulfur cluster-binding domain	pqqE	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
CMS2_k127_4416631_2	545695.TREAZ_0667	4.781e-113	377.0	COG2865@1|root,COG2865@2|Bacteria,2J707@203691|Spirochaetes	203691|Spirochaetes	K	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2,HATPase_c_4
CMS2_k127_4416631_3	1408473.JHXO01000012_gene274	1.075e-83	292.0	COG1453@1|root,COG1453@2|Bacteria,4NGCW@976|Bacteroidetes,2FPG8@200643|Bacteroidia	976|Bacteroidetes	S	Tat pathway signal sequence domain protein	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
CMS2_k127_4416631_6	269797.Mbar_A1378	5.796e-24	108.0	COG0655@1|root,arCOG02572@2157|Archaea,2XYS8@28890|Euryarchaeota,2N9WE@224756|Methanomicrobia	224756|Methanomicrobia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS2_k127_4416631_4	1121440.AUMA01000003_gene2931	1.455e-43	162.0	COG0599@1|root,COG0599@2|Bacteria,1N38Z@1224|Proteobacteria,42WA7@68525|delta/epsilon subdivisions,2WRWX@28221|Deltaproteobacteria,2MCC2@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS2_k127_4416631_0	448385.sce2682	5.089e-186	658.0	COG3291@1|root,COG3291@2|Bacteria,1QXA4@1224|Proteobacteria,43C3G@68525|delta/epsilon subdivisions,2X7E3@28221|Deltaproteobacteria,2YV4F@29|Myxococcales	28221|Deltaproteobacteria	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
CMS2_k127_4416631_9	1499967.BAYZ01000139_gene136	8.721e-05	58.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CHU_C,PKD,SLH,SprB
CMS2_k127_4416631_5	1197706.AKKK01000002_gene4105	1.585e-37	167.0	COG1404@1|root,COG4932@1|root,COG1404@2|Bacteria,COG4932@2|Bacteria,2GQDQ@201174|Actinobacteria,1WBJI@1268|Micrococcaceae	201174|Actinobacteria	MO	S-layer domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,SLH
CMS2_k127_4416631_1	1077972.ARGLB_080_00570	6.544e-124	453.0	COG4932@1|root,COG4932@2|Bacteria,2GXWA@201174|Actinobacteria,1W96H@1268|Micrococcaceae	201174|Actinobacteria	M	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS2_k127_4422412_1	1458357.BG58_25890	0.0	1651.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,1JZUU@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	amino acid adenylation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,PP-binding,Thioesterase
CMS2_k127_4422412_2	1120966.AUBU01000002_gene2066	8.02e-230	724.0	COG2274@1|root,COG2274@2|Bacteria,4NE19@976|Bacteroidetes,47MDS@768503|Cytophagia	976|Bacteroidetes	V	ABC transporter transmembrane region	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran,Peptidase_C39
CMS2_k127_4422412_0	118161.KB235922_gene2554	0.0	1885.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,3VII7@52604|Pleurocapsales	1117|Cyanobacteria	Q	COGs COG1020 Non-ribosomal peptide synthetase modules and related protein	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4427810_0	697284.ERIC2_c19920	3.648e-209	679.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4439444_3	743299.Acife_0178	9.927e-32	125.0	COG2865@1|root,COG2865@2|Bacteria,1PF1D@1224|Proteobacteria,1S0GE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
CMS2_k127_4439444_1	237368.SCABRO_01150	1.715e-37	145.0	COG1487@1|root,COG1487@2|Bacteria,2J1EF@203682|Planctomycetes	203682|Planctomycetes	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
CMS2_k127_4439444_6	580340.Tlie_1807	4.229e-05	53.0	COG2161@1|root,COG2161@2|Bacteria	2|Bacteria	D	toxin-antitoxin pair type II binding	-	-	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
CMS2_k127_4439444_5	1313421.JHBV01000015_gene5729	1.394e-09	62.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,Gram_pos_anchor
CMS2_k127_4439444_2	357808.RoseRS_3823	2.183e-32	127.0	2E95X@1|root,333EM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4439444_4	1128427.KB904821_gene1694	2.463e-20	92.0	COG5428@1|root,COG5428@2|Bacteria,1G9S2@1117|Cyanobacteria,1HDCW@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
CMS2_k127_4439444_0	1455608.JDTH01000005_gene2738	2.223e-54	207.0	COG0006@1|root,arCOG01000@2157|Archaea,2XVY0@28890|Euryarchaeota,23U8B@183963|Halobacteria	183963|Halobacteria	E	COG0006 Xaa-Pro aminopeptidase	pepB5	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
CMS2_k127_4445339_2	1396141.BATP01000006_gene5437	4.933e-13	70.0	COG1064@1|root,COG1064@2|Bacteria,46VI4@74201|Verrucomicrobia,2ITWZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Alanine dehydrogenase/PNT, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS2_k127_4445339_0	219305.MCAG_05245	2.815e-119	391.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4DAXK@85008|Micromonosporales	201174|Actinobacteria	EK	Cystathionine beta-synthase	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_4445339_3	1249975.JQLP01000005_gene1972	8.488e-08	60.0	COG4704@1|root,COG4704@2|Bacteria,4NUS8@976|Bacteroidetes,1I3YT@117743|Flavobacteriia,2P6Z5@244698|Gillisia	976|Bacteroidetes	S	Uncharacterized protein conserved in bacteria (DUF2141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2141
CMS2_k127_4445339_1	1120956.JHZK01000006_gene676	1.195e-41	158.0	COG0454@1|root,COG0456@2|Bacteria,1N8A4@1224|Proteobacteria	1224|Proteobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_4463442_1	755731.Clo1100_2633	0.0	1070.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4463442_2	697284.ERIC2_c18040	1.617e-255	883.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4463442_0	118005.AWNK01000004_gene1064	0.0	1447.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4463442_4	385682.AFSL01000073_gene1404	3.938e-222	700.0	COG4690@1|root,COG4690@2|Bacteria,4NE03@976|Bacteroidetes,2FPSX@200643|Bacteroidia,3XJ9B@558415|Marinilabiliaceae	976|Bacteroidetes	E	Peptidase family C69	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
CMS2_k127_4463442_29	448385.sce5864	0.00013	54.0	COG0745@1|root,COG1196@1|root,COG0745@2|Bacteria,COG1196@2|Bacteria,1QXA6@1224|Proteobacteria,43E4U@68525|delta/epsilon subdivisions,2X7E9@28221|Deltaproteobacteria,2YVVM@29|Myxococcales	28221|Deltaproteobacteria	DKT	Response regulator receiver domain	frzS	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_4463442_27	1235457.C404_17545	1.349e-13	78.0	28R8P@1|root,2ZDNC@2|Bacteria,1PBH5@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4463442_5	1121289.JHVL01000041_gene3071	7.086e-172	554.0	COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,248DZ@186801|Clostridia,36EVZ@31979|Clostridiaceae	186801|Clostridia	T	carbon starvation protein CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
CMS2_k127_4463442_10	643648.Slip_0605	1.268e-148	486.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,42JKA@68298|Syntrophomonadaceae	186801|Clostridia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS04230	AICARFT_IMPCHas,MGS
CMS2_k127_4463442_9	1121121.KB894288_gene2756	2.415e-157	503.0	COG3882@1|root,COG3882@2|Bacteria,1TTCC@1239|Firmicutes,4HF60@91061|Bacilli,26TJJ@186822|Paenibacillaceae	91061|Bacilli	Q	HAD-superfamily phosphatase, subfamily IIIC	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
CMS2_k127_4463442_25	697284.ERIC2_c18190	5.395e-28	114.0	COG0236@1|root,COG0236@2|Bacteria,1VMCB@1239|Firmicutes,4HR5M@91061|Bacilli,26ZWJ@186822|Paenibacillaceae	91061|Bacilli	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
CMS2_k127_4463442_6	588581.Cpap_1804	1.638e-166	531.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,3WI1F@541000|Ruminococcaceae	186801|Clostridia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.6	ko:K00252,ko:K18244	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS2_k127_4463442_28	1463921.JODF01000031_gene2743	3.86e-05	51.0	COG4243@1|root,COG4243@2|Bacteria,2GMVK@201174|Actinobacteria	201174|Actinobacteria	S	Vitamin K epoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
CMS2_k127_4463442_24	247490.KSU1_B0196	2.66e-30	127.0	COG4798@1|root,COG4798@2|Bacteria,2J4ZF@203682|Planctomycetes	203682|Planctomycetes	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
CMS2_k127_4463442_3	1158294.JOMI01000007_gene434	1.111e-228	730.0	COG3669@1|root,COG3669@2|Bacteria,4NGKB@976|Bacteroidetes,2FM4I@200643|Bacteroidia	976|Bacteroidetes	G	Alpha-N-acetylglucosaminidase	-	-	3.2.1.50	ko:K01205	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078	R07816	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	NAGLU,NAGLU_C,NAGLU_N
CMS2_k127_4463442_26	526222.Desal_0337	1.82e-20	98.0	COG1633@1|root,COG1633@2|Bacteria,1PZCB@1224|Proteobacteria,435VZ@68525|delta/epsilon subdivisions,2X0BU@28221|Deltaproteobacteria,2MBRF@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4463442_20	1195236.CTER_4287	1.211e-52	197.0	COG0696@1|root,COG0696@2|Bacteria,1UYDB@1239|Firmicutes,24BJ3@186801|Clostridia,3WNKY@541000|Ruminococcaceae	186801|Clostridia	G	PFAM Metalloenzyme	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme
CMS2_k127_4463442_23	742817.HMPREF9449_01705	1.141e-33	133.0	COG1188@1|root,COG1188@2|Bacteria,4NP8I@976|Bacteroidetes,2FRYM@200643|Bacteroidia,22Y0I@171551|Porphyromonadaceae	976|Bacteroidetes	J	S4 domain protein	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
CMS2_k127_4463442_12	1121406.JAEX01000019_gene2772	1.46e-127	432.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2M865@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
CMS2_k127_4463442_11	1178825.ALIH01000015_gene1934	5.934e-135	452.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	3.4.14.10	ko:K01280	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	PPC,Peptidase_S8
CMS2_k127_4463442_16	1410613.JNKF01000010_gene350	2.469e-83	287.0	28NTF@1|root,2Z7JQ@2|Bacteria,4NGU0@976|Bacteroidetes	976|Bacteroidetes	S	RNA ligase	-	-	-	-	-	-	-	-	-	-	-	-	RNA_ligase
CMS2_k127_4463442_19	385682.AFSL01000088_gene897	4.31e-64	229.0	COG2518@1|root,COG2518@2|Bacteria,4NMTP@976|Bacteroidetes,2FXTG@200643|Bacteroidia,3XJR3@558415|Marinilabiliaceae	976|Bacteroidetes	O	Ribosomal RNA adenine dimethylase	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CMS2_k127_4463442_8	1047013.AQSP01000133_gene2107	4.876e-158	506.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
CMS2_k127_4463442_14	56107.Cylst_0426	3.162e-112	401.0	COG0823@1|root,COG5276@1|root,COG0823@2|Bacteria,COG5276@2|Bacteria,1GQ7S@1117|Cyanobacteria,1HRXM@1161|Nostocales	1117|Cyanobacteria	Q	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF4347,HemolysinCabind,LVIVD
CMS2_k127_4463442_15	439235.Dalk_0237	1.268e-95	350.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_4463442_7	1047013.AQSP01000111_gene1667	5.3e-166	537.0	COG4690@1|root,COG4690@2|Bacteria	2|Bacteria	E	dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
CMS2_k127_4463442_21	1125699.HMPREF9194_00391	4.243e-41	161.0	28N4D@1|root,2ZB9V@2|Bacteria,2J7NR@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4463442_22	1298920.KI911353_gene5349	1.15e-37	151.0	arCOG13338@1|root,2ZA1I@2|Bacteria,1V5GH@1239|Firmicutes,2488N@186801|Clostridia,220QC@1506553|Lachnoclostridium	186801|Clostridia	S	Domain of unknown function (DUF5058)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5058
CMS2_k127_4463442_13	1047013.AQSP01000110_gene82	4.429e-117	392.0	2CI8B@1|root,334QN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4463442_17	1048983.EL17_08015	2.359e-81	283.0	COG1680@1|root,COG1680@2|Bacteria,4NEVS@976|Bacteroidetes,47JKN@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_4472654_0	394503.Ccel_0859	2.392e-316	1008.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13612	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_4472654_1	1307759.JOMJ01000003_gene2091	1.294e-12	68.0	COG1192@1|root,COG1192@2|Bacteria,1Q9Y4@1224|Proteobacteria,42ZVG@68525|delta/epsilon subdivisions,2WV5I@28221|Deltaproteobacteria,2MFX2@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
CMS2_k127_450843_7	391165.GbCGDNIH1_1534	6.15e-09	66.0	COG0859@1|root,COG0859@2|Bacteria,1QWW4@1224|Proteobacteria	1224|Proteobacteria	M	Glycosyltransferase WbsX	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_WbsX,Glyco_transf_9
CMS2_k127_450843_1	203119.Cthe_1172	1.664e-126	416.0	COG1146@1|root,COG2006@1|root,COG1146@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,3WHJ8@541000|Ruminococcaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
CMS2_k127_450843_3	1121403.AUCV01000012_gene4109	6.11e-69	267.0	COG1075@1|root,COG1075@2|Bacteria,1QD4I@1224|Proteobacteria,435MR@68525|delta/epsilon subdivisions,2X9BC@28221|Deltaproteobacteria,2MNSY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_450843_4	1237149.C900_00096	7.761e-55	221.0	COG3227@1|root,COG3291@1|root,COG4447@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,COG4447@2|Bacteria,4NEZQ@976|Bacteroidetes,47PGJ@768503|Cytophagia	976|Bacteroidetes	G	Participates in initiation and elongation during chromosome replication	-	-	-	-	-	-	-	-	-	-	-	-	MAM,Sortilin-Vps10
CMS2_k127_450843_5	868131.MSWAN_2369	2.871e-11	78.0	COG1520@1|root,COG3291@1|root,arCOG02492@2157|Archaea,arCOG02508@2157|Archaea	2157|Archaea	G	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_3_5,Big_5,CHB_HEX_C_1,PKD,PQQ_3
CMS2_k127_450843_0	502025.Hoch_1667	4.039e-136	475.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_450843_2	1121403.AUCV01000012_gene4109	3.184e-80	277.0	COG1075@1|root,COG1075@2|Bacteria,1QD4I@1224|Proteobacteria,435MR@68525|delta/epsilon subdivisions,2X9BC@28221|Deltaproteobacteria,2MNSY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4528658_9	765913.ThidrDRAFT_3611	5.179e-68	250.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,1N26H@1224|Proteobacteria	1224|Proteobacteria	T	Sulfatase-modifying factor enzyme 1	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	DUF4062,FGE-sulfatase,NACHT
CMS2_k127_4528658_14	555779.Dthio_PD0039	9.889e-05	48.0	COG5464@1|root,COG5464@2|Bacteria,1MUSP@1224|Proteobacteria,432C3@68525|delta/epsilon subdivisions,2WXKF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	transposase YhgA family protein	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_31
CMS2_k127_4528658_3	880073.Calab_1160	1.18e-149	515.0	COG0553@1|root,COG0553@2|Bacteria,2NQCJ@2323|unclassified Bacteria	2|Bacteria	KL	SNF2 family N-terminal domain	rapA	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
CMS2_k127_4528658_10	243231.GSU1013	4.298e-30	133.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,42T2J@68525|delta/epsilon subdivisions,2WPPV@28221|Deltaproteobacteria,43TEW@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	OmpA family	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
CMS2_k127_4528658_6	485916.Dtox_3177	2.423e-77	274.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,260B8@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the peptidase M16 family	ymxG	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_4528658_8	1379281.AVAG01000010_gene1342	3.644e-70	241.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,42MEH@68525|delta/epsilon subdivisions,2WMSC@28221|Deltaproteobacteria,2M92Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
CMS2_k127_4528658_2	204669.Acid345_0212	2.163e-177	567.0	COG1220@1|root,COG1220@2|Bacteria,3Y2K2@57723|Acidobacteria,2JIS7@204432|Acidobacteriia	204432|Acidobacteriia	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
CMS2_k127_4528658_13	494419.ALPM01000075_gene1569	3.737e-10	72.0	COG0810@1|root,COG3401@1|root,COG4733@1|root,COG0810@2|Bacteria,COG3401@2|Bacteria,COG4733@2|Bacteria,2HCWC@201174|Actinobacteria	201174|Actinobacteria	Q	PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	Malectin,PA14
CMS2_k127_4528658_4	203119.Cthe_1172	8.86e-132	430.0	COG1146@1|root,COG2006@1|root,COG1146@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,3WHJ8@541000|Ruminococcaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
CMS2_k127_4528658_11	1047013.AQSP01000071_gene1937	9.413e-24	104.0	COG0848@1|root,COG0848@2|Bacteria,2NPWJ@2323|unclassified Bacteria	2|Bacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
CMS2_k127_4528658_0	1237149.C900_04816	3.173e-239	790.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47TR0@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Response_reg,Y_Y_Y
CMS2_k127_4528658_1	1047013.AQSP01000084_gene761	8.181e-189	597.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS2_k127_4528658_5	1047013.AQSP01000100_gene590	6.705e-92	311.0	COG2362@1|root,COG2362@2|Bacteria,2NPDW@2323|unclassified Bacteria	2|Bacteria	E	D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
CMS2_k127_4579340_1	755731.Clo1100_0888	3.002e-240	773.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K13611,ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
CMS2_k127_4579340_2	509191.AEDB02000067_gene919	4.208e-107	365.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4579340_3	1231241.Mc24_03603	2.011e-54	196.0	COG2316@1|root,COG2316@2|Bacteria,2GCT9@200918|Thermotogae	200918|Thermotogae	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06951	-	-	-	-	ko00000	-	-	-	HD
CMS2_k127_4579340_4	204669.Acid345_3020	1.226e-39	156.0	COG2834@1|root,COG2834@2|Bacteria,3Y7NW@57723|Acidobacteria	57723|Acidobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4579340_0	313606.M23134_07566	1.24e-322	1017.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47P32@768503|Cytophagia	976|Bacteroidetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
CMS2_k127_4585752_0	1121451.DESAM_10036	4.811e-81	295.0	COG1518@1|root,COG3344@1|root,COG1518@2|Bacteria,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Q0C@68525|delta/epsilon subdivisions,2WIIZ@28221|Deltaproteobacteria,2MDPJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
CMS2_k127_4585752_3	1235802.C823_04072	0.0005102	43.0	COG5464@1|root,COG5464@2|Bacteria,1V032@1239|Firmicutes,25D0W@186801|Clostridia	186801|Clostridia	S	PD-(D/E)XK nuclease family transposase	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_4585752_1	118163.Ple7327_2254	9.048e-56	205.0	COG0742@1|root,COG0742@2|Bacteria,1G5DR@1117|Cyanobacteria	1117|Cyanobacteria	L	ribosomal rna small subunit methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4585752_2	1408419.JHYG01000005_gene591	1.854e-27	117.0	COG0535@1|root,COG0535@2|Bacteria,1PHFS@1224|Proteobacteria,2VE4X@28211|Alphaproteobacteria,2JVSI@204441|Rhodospirillales	204441|Rhodospirillales	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_4599771_0	1191523.MROS_2005	4.305e-130	461.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4599771_1	1267533.KB906735_gene4464	1.06e-44	188.0	28M6X@1|root,2ZAKG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_99
CMS2_k127_4599771_2	1121898.Q766_04220	1.378e-23	106.0	COG2405@1|root,COG2405@2|Bacteria,4NSZC@976|Bacteroidetes,1IA55@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF3368)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3368
CMS2_k127_4599771_4	1122176.KB903591_gene4777	2.039e-10	64.0	COG2886@1|root,COG2886@2|Bacteria,4NYD2@976|Bacteroidetes	976|Bacteroidetes	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
CMS2_k127_4599771_3	660470.Theba_0222	5.645e-12	78.0	COG1470@1|root,COG3291@1|root,COG1470@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,NPCBM,NPCBM_assoc,PEGA
CMS2_k127_4613127_12	2423.NA23_0206420	1.205e-09	67.0	COG1933@1|root,COG1933@2|Bacteria,2GDRW@200918|Thermotogae	200918|Thermotogae	L	exodeoxyribonuclease I activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4613127_9	1236514.BAKL01000015_gene1638	4.458e-22	105.0	28KSZ@1|root,2ZAA8@2|Bacteria,4NHC3@976|Bacteroidetes,2FVKP@200643|Bacteroidia,4ASWA@815|Bacteroidaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4613127_14	1236514.BAKL01000015_gene1639	1.573e-07	61.0	COG1475@1|root,COG1475@2|Bacteria,4P1X3@976|Bacteroidetes,2FRXC@200643|Bacteroidia,4AW85@815|Bacteroidaceae	976|Bacteroidetes	K	ParB-like nuclease domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4417,ParBc
CMS2_k127_4613127_10	888832.HMPREF9420_1831	2.083e-15	79.0	COG3311@1|root,COG3311@2|Bacteria,4NSAH@976|Bacteroidetes,2FT2T@200643|Bacteroidia	976|Bacteroidetes	K	DNA binding domain, excisionase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
CMS2_k127_4613127_7	880070.Cycma_4293	5.006e-70	250.0	COG0582@1|root,COG0582@2|Bacteria,4PKC8@976|Bacteroidetes,47N2F@768503|Cytophagia	976|Bacteroidetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_5,Phage_int_SAM_5,Phage_integrase
CMS2_k127_4613127_3	696747.NIES39_A04250	1.489e-168	544.0	COG1640@1|root,COG1640@2|Bacteria,1G0F2@1117|Cyanobacteria,1H7YB@1150|Oscillatoriales	1117|Cyanobacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	iJN678.malQ	Glyco_hydro_77
CMS2_k127_4613127_2	1168034.FH5T_18810	1.27e-221	700.0	COG0405@1|root,COG0405@2|Bacteria,4NF2H@976|Bacteroidetes,2FSHQ@200643|Bacteroidia	976|Bacteroidetes	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CMS2_k127_4613127_8	1249997.JHZW01000003_gene2150	5.228e-64	253.0	COG2133@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,4PI47@976|Bacteroidetes,1IM97@117743|Flavobacteriia,2PI57@252356|Maribacter	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,PKD
CMS2_k127_4613127_11	225849.swp_4850	3.198e-13	85.0	COG1404@1|root,COG1512@1|root,COG5183@1|root,COG1404@2|Bacteria,COG1512@2|Bacteria,COG5183@2|Bacteria,1R8J8@1224|Proteobacteria,1S0HR@1236|Gammaproteobacteria,2QD7Y@267890|Shewanellaceae	1236|Gammaproteobacteria	AO	Collagenase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M9
CMS2_k127_4613127_4	1443665.JACA01000051_gene2036	3.397e-106	364.0	COG3591@1|root,COG3591@2|Bacteria	2|Bacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,NB-ARC,PKD,PPC,Sel1,Trypsin,Trypsin_2
CMS2_k127_4613127_0	234267.Acid_3931	2.153e-260	833.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS2_k127_4613127_6	1047013.AQSP01000085_gene1994	1.661e-73	255.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS2_k127_4613127_5	1499967.BAYZ01000105_gene3502	1.07e-85	293.0	COG3971@1|root,COG3971@2|Bacteria	2|Bacteria	Q	2-oxopent-4-enoate hydratase activity	-	-	4.2.1.80	ko:K02554	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R02601,R04781	RC00750,RC01213	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	-
CMS2_k127_4613127_1	1121946.AUAX01000035_gene6178	9.008e-234	744.0	COG0330@1|root,COG0330@2|Bacteria,2I9AF@201174|Actinobacteria	201174|Actinobacteria	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS2_k127_4617284_13	313606.M23134_07246	1.214e-110	392.0	COG2203@1|root,COG2208@1|root,COG3292@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3292@2|Bacteria,4NKGA@976|Bacteroidetes,47TQU@768503|Cytophagia	976|Bacteroidetes	T	Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,SpoIIE,Y_Y_Y
CMS2_k127_4617284_41	313606.M23134_00275	1.938e-22	114.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS2_k127_4617284_0	1047013.AQSP01000101_gene610	0.0	1644.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2NP1J@2323|unclassified Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0016625,GO:0016903,GO:0043873,GO:0050896,GO:0055114	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iJN678.nifJ,iLF82_1304.LF82_2789,iNRG857_1313.NRG857_06920	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
CMS2_k127_4617284_45	768704.Desmer_1872	6.725e-17	89.0	COG0655@1|root,COG0655@2|Bacteria,1UZKQ@1239|Firmicutes,25CAS@186801|Clostridia,265CK@186807|Peptococcaceae	186801|Clostridia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS2_k127_4617284_11	556268.OFAG_00031	6.37e-132	434.0	COG0786@1|root,COG0786@2|Bacteria,1R7XT@1224|Proteobacteria	1224|Proteobacteria	E	glutamate symporter	-	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
CMS2_k127_4617284_14	35841.BT1A1_3208	1.839e-110	373.0	COG1301@1|root,COG1301@2|Bacteria,1TPME@1239|Firmicutes,4H9T7@91061|Bacilli,1ZCSU@1386|Bacillus	91061|Bacilli	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
CMS2_k127_4617284_9	639282.DEFDS_1847	5.976e-143	460.0	COG2358@1|root,COG2358@2|Bacteria,2GF41@200930|Deferribacteres	200930|Deferribacteres	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
CMS2_k127_4617284_2	639282.DEFDS_1846	1.13e-268	842.0	COG4666@1|root,COG4666@2|Bacteria,2GEUP@200930|Deferribacteres	200930|Deferribacteres	S	transport system permease	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
CMS2_k127_4617284_10	502025.Hoch_1667	6.416e-138	462.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_4617284_40	349521.HCH_02477	5.992e-33	147.0	COG4935@1|root,COG5276@1|root,COG4935@2|Bacteria,COG5276@2|Bacteria,1R5D5@1224|Proteobacteria,1RMBK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,LVIVD,P_proprotein
CMS2_k127_4617284_8	502025.Hoch_1667	1.969e-143	478.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_4617284_16	402777.KB235904_gene4088	4.675e-101	342.0	COG0673@1|root,COG0673@2|Bacteria,1GEU5@1117|Cyanobacteria	1117|Cyanobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	ko:K18106	ko00040,ko01100,map00040,map01100	M00630	R07676,R10565	RC00108	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA
CMS2_k127_4617284_32	1207058.L53_01730	8.641e-50	186.0	COG1083@1|root,COG1083@2|Bacteria,1QACI@1224|Proteobacteria,2U5PV@28211|Alphaproteobacteria,43YYJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Cytidylyltransferase	-	-	2.7.7.43	ko:K00983	ko00520,ko01100,map00520,map01100	-	R01117,R04215	RC00152	ko00000,ko00001,ko01000	-	-	-	CTP_transf_3
CMS2_k127_4617284_23	179408.Osc7112_0111	2.245e-81	284.0	COG2755@1|root,COG2755@2|Bacteria,1GD2I@1117|Cyanobacteria,1HEYA@1150|Oscillatoriales	1117|Cyanobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4617284_50	1191523.MROS_1643	4.067e-11	64.0	2EGPU@1|root,33AFZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4617284_35	685778.AORL01000021_gene912	1.393e-40	161.0	COG0500@1|root,COG2226@2|Bacteria,1PNWS@1224|Proteobacteria,2V1FW@28211|Alphaproteobacteria,2KBHN@204457|Sphingomonadales	204457|Sphingomonadales	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4617284_5	1379698.RBG1_1C00001G0679	3.159e-198	636.0	COG2192@1|root,COG2192@2|Bacteria,2NNRR@2323|unclassified Bacteria	2|Bacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS2_k127_4617284_12	204669.Acid345_2108	6.863e-113	377.0	COG0766@1|root,COG0766@2|Bacteria,3Y2IC@57723|Acidobacteria,2JI7D@204432|Acidobacteriia	204432|Acidobacteriia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
CMS2_k127_4617284_37	224324.aq_141	2.581e-35	137.0	COG0537@1|root,COG0537@2|Bacteria,2G44F@200783|Aquificae	200783|Aquificae	FG	PFAM Histidine triad (HIT) protein	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
CMS2_k127_4617284_26	572546.Arcpr_0036	4.154e-63	223.0	COG2220@1|root,arCOG00497@2157|Archaea,2XTCN@28890|Euryarchaeota,245Z6@183980|Archaeoglobi	183980|Archaeoglobi	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CMS2_k127_4617284_42	1047013.AQSP01000139_gene2388	7.369e-22	100.0	COG3688@1|root,COG3688@2|Bacteria,2NQ5V@2323|unclassified Bacteria	2|Bacteria	S	YacP-like NYN domain	yacP	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_IV,GTP_EFTU,NYN_YacP
CMS2_k127_4617284_39	439235.Dalk_1778	4.547e-33	138.0	COG5495@1|root,COG5495@2|Bacteria,1RBEZ@1224|Proteobacteria,42PJR@68525|delta/epsilon subdivisions,2WPBQ@28221|Deltaproteobacteria,2MI0V@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF2520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
CMS2_k127_4617284_25	1267535.KB906767_gene5244	2.389e-67	249.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Glyco_tranf_2_3,Glycos_transf_2,Sulfatase
CMS2_k127_4617284_49	930945.SiRe_1016	5.49e-12	73.0	COG1846@1|root,arCOG03181@2157|Archaea	2157|Archaea	K	Transcriptional regulator MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR
CMS2_k127_4617284_3	1499967.BAYZ01000134_gene8	1.967e-259	823.0	COG1509@1|root,COG1509@2|Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
CMS2_k127_4617284_27	1237149.C900_04325	4.591e-63	224.0	COG0739@1|root,COG0739@2|Bacteria,4NN4Q@976|Bacteroidetes,47PNX@768503|Cytophagia	976|Bacteroidetes	M	PFAM Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CMS2_k127_4617284_4	385682.AFSL01000039_gene145	3.157e-208	655.0	COG1509@1|root,COG1509@2|Bacteria,4NJ79@976|Bacteroidetes,2G2FM@200643|Bacteroidia,3XJK2@558415|Marinilabiliaceae	976|Bacteroidetes	E	Lysine-2,3-aminomutase	ablA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
CMS2_k127_4617284_17	877455.Metbo_0091	5.318e-97	340.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,23NMV@183925|Methanobacteria	183925|Methanobacteria	F	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
CMS2_k127_4617284_55	52644.XP_010566764.1	0.0002171	48.0	COG0457@1|root,KOG0153@1|root,KOG0153@2759|Eukaryota,KOG0548@2759|Eukaryota,39SZH@33154|Opisthokonta,3BF8D@33208|Metazoa,3CX0N@33213|Bilateria,48CMA@7711|Chordata,495ZT@7742|Vertebrata,4GK2C@8782|Aves	33208|Metazoa	A	tetratricopeptide repeat	TTC31	-	-	-	-	-	-	-	-	-	-	-	RRM_1,TPR_16,TPR_2,TPR_8
CMS2_k127_4617284_53	314230.DSM3645_18671	1.197e-08	58.0	COG0591@1|root,COG0591@2|Bacteria,2J2U0@203682|Planctomycetes	203682|Planctomycetes	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
CMS2_k127_4617284_34	290318.Cvib_1366	2.822e-46	171.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_4617284_29	1449126.JQKL01000071_gene3639	1.48e-53	214.0	COG0784@1|root,COG2202@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1UJJI@1239|Firmicutes,25F4M@186801|Clostridia	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg
CMS2_k127_4617284_31	706587.Desti_2024	1.959e-52	211.0	COG0784@1|root,COG0834@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MQW1@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
CMS2_k127_4617284_54	555779.Dthio_PD0392	3.098e-07	65.0	COG0457@1|root,COG5635@1|root,COG0457@2|Bacteria,COG5635@2|Bacteria,1MWRF@1224|Proteobacteria,42T1Q@68525|delta/epsilon subdivisions,2X5JE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHAT,NB-ARC,Pkinase,TIR_2,TPR_12,TPR_16,TPR_2,TPR_4,TPR_7,TPR_8
CMS2_k127_4617284_43	1499967.BAYZ01000036_gene2434	3.17e-20	96.0	COG2260@1|root,COG2260@2|Bacteria	2|Bacteria	J	snoRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
CMS2_k127_4617284_21	945713.IALB_2055	2.675e-87	299.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
CMS2_k127_4617284_48	1046627.BZARG_3026	2.168e-15	88.0	COG3088@1|root,COG3088@2|Bacteria,4NGHU@976|Bacteroidetes,1HY3G@117743|Flavobacteriia	976|Bacteroidetes	O	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4617284_20	880073.Calab_2467	1.624e-90	306.0	COG1721@1|root,COG1721@2|Bacteria,2NNQI@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF58	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF58
CMS2_k127_4617284_51	1123376.AUIU01000017_gene105	1.581e-10	64.0	COG3465@1|root,COG3465@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
CMS2_k127_4617284_28	1027273.GZ77_13855	8.359e-62	227.0	COG0078@1|root,COG0078@2|Bacteria,1N4DE@1224|Proteobacteria,1RSHV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the ATCase OTCase family	ygeW	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0019627,GO:0034641,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
CMS2_k127_4617284_47	1293054.HSACCH_01357	1.022e-15	84.0	COG0558@1|root,COG0558@2|Bacteria,1V35A@1239|Firmicutes,24IIY@186801|Clostridia,3WAV3@53433|Halanaerobiales	186801|Clostridia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA2	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS2_k127_4617284_44	373903.Hore_13280	6.816e-18	88.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,248BR@186801|Clostridia,3WB06@53433|Halanaerobiales	186801|Clostridia	K	Response regulator receiver	-	-	-	ko:K02483,ko:K18344	ko01502,ko02020,map01502,map02020	M00651,M00656	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_4617284_22	1487921.DP68_04740	1.838e-86	295.0	COG1242@1|root,COG1242@2|Bacteria,1TQ57@1239|Firmicutes,247U3@186801|Clostridia,36DHV@31979|Clostridiaceae	186801|Clostridia	S	radical SAM protein	ytqA	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
CMS2_k127_4617284_30	387092.NIS_1538	3.32e-53	192.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2YNVV@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	bacterioferritin comigratory protein	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
CMS2_k127_4617284_18	1047013.AQSP01000142_gene195	2.501e-96	327.0	COG0787@1|root,COG0787@2|Bacteria,2NP3R@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
CMS2_k127_4617284_15	404589.Anae109_2705	4.427e-104	349.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ4Z@28221|Deltaproteobacteria,2YXJE@29|Myxococcales	28221|Deltaproteobacteria	NU	twitching motility protein	pilT1	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS2_k127_4617284_1	1047013.AQSP01000130_gene1862	0.0	1037.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2NNS9@2323|unclassified Bacteria	2|Bacteria	EU	peptidase S9 prolyl oligopeptidase active site	ptpA_1	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008239,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042597,GO:0042802,GO:0042803,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044464,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS2_k127_4617284_19	595460.RRSWK_05386	1.948e-91	308.0	COG1913@1|root,COG1913@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
CMS2_k127_4617284_46	1123487.KB892843_gene788	9.679e-17	86.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2VSIP@28216|Betaproteobacteria,2KWDE@206389|Rhodocyclales	206389|Rhodocyclales	H	molybdopterin-guanine dinucleotide biosynthesis protein	-	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
CMS2_k127_4617284_36	459349.CLOAM0708	4.446e-37	143.0	COG0437@1|root,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	ko:K00196	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	-	R07157,R08034	RC00250,RC02800	ko00000,ko00001	-	-	-	Fer4,Fer4_4,Fer4_6
CMS2_k127_4617284_24	1047013.AQSP01000096_gene2180	5.178e-74	278.0	COG2414@1|root,COG2414@2|Bacteria,2NNME@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS2_k127_4617284_7	335541.Swol_1701	2.011e-149	503.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42JNT@68298|Syntrophomonadaceae	186801|Clostridia	C	NADH dehydrogenase (quinone)	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
CMS2_k127_4617284_38	1089553.Tph_c08260	1.174e-33	149.0	COG3383@1|root,COG3383@2|Bacteria,1V5BD@1239|Firmicutes,24ER9@186801|Clostridia	186801|Clostridia	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4,Fer4_7
CMS2_k127_4617284_6	1047013.AQSP01000096_gene2180	2.622e-193	623.0	COG2414@1|root,COG2414@2|Bacteria,2NNME@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS2_k127_4617284_33	459349.CLOAM1487	4.583e-47	176.0	COG0476@1|root,COG0476@2|Bacteria,2NPRM@2323|unclassified Bacteria	2|Bacteria	H	ThiF family	thiF	-	2.7.7.73,2.7.7.80	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
CMS2_k127_4617284_52	580340.Tlie_1227	1.071e-09	61.0	COG2104@1|root,COG2104@2|Bacteria,3TBHX@508458|Synergistetes	508458|Synergistetes	H	thiamine biosynthesis protein ThiS	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
CMS2_k127_462396_0	1209072.ALBT01000082_gene284	3.958e-13	80.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RSE7@1236|Gammaproteobacteria,1FG5F@10|Cellvibrio	1236|Gammaproteobacteria	M	TIGRFAM YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS,RHS_repeat
CMS2_k127_462396_1	316067.Geob_1034	1.171e-09	64.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,43SWS@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	RHS protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4150,RHS,RHS_repeat
CMS2_k127_4678981_26	999541.bgla_2g29490	3.587e-27	115.0	COG3209@1|root,COG3210@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria,1MX2K@1224|Proteobacteria,2VI40@28216|Betaproteobacteria,1K0FX@119060|Burkholderiaceae	28216|Betaproteobacteria	U	TIGRFAM filamentous haemagglutinin family outer membrane protein	-	-	-	ko:K15125	ko05133,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	ESPR,Fil_haemagg,Fil_haemagg_2,Haemagg_act,PT-VENN
CMS2_k127_4678981_30	56107.Cylst_4485	4.805e-16	82.0	2EKKN@1|root,33EAG@2|Bacteria,1GFDS@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4678981_21	760192.Halhy_1128	1.548e-43	182.0	COG3209@1|root,COG3209@2|Bacteria,4NFUE@976|Bacteroidetes,1INSI@117747|Sphingobacteriia	976|Bacteroidetes	M	COG3209 Rhs family protein	rhsA	-	-	-	-	-	-	-	-	-	-	-	RHS,RHS_repeat
CMS2_k127_4678981_27	1195236.CTER_3815	4.473e-27	128.0	COG2866@1|root,COG3209@1|root,COG2866@2|Bacteria,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia,3WHQ2@541000|Ruminococcaceae	186801|Clostridia	M	RHS repeat-associated core domain	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
CMS2_k127_4678981_33	439235.Dalk_2288	5.674e-15	78.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,2MPW6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4150,RHS,RHS_repeat,Transglut_core
CMS2_k127_4678981_40	1133849.O3I_020045	7.088e-05	48.0	COG1541@1|root,COG1541@2|Bacteria,2HHBU@201174|Actinobacteria,4FX7W@85025|Nocardiaceae	201174|Actinobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	-
CMS2_k127_4678981_31	686340.Metal_2986	7.035e-16	78.0	COG1541@1|root,COG1541@2|Bacteria,1R8T9@1224|Proteobacteria,1S1JC@1236|Gammaproteobacteria,1XEUW@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	-
CMS2_k127_4678981_13	1158318.ATXC01000001_gene587	1.439e-67	264.0	COG2204@1|root,COG2204@2|Bacteria,2G3HZ@200783|Aquificae	200783|Aquificae	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_4678981_17	880072.Desac_2741	5.943e-53	207.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1NE6G@1224|Proteobacteria,4321S@68525|delta/epsilon subdivisions,2WWD7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
CMS2_k127_4678981_4	1047013.AQSP01000135_gene1594	3.331e-163	522.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2NNKV@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.4.25,4.1.99.12	ko:K01497,ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830,iSB619.SA_RS08945	DHBP_synthase,GTP_cyclohydro2
CMS2_k127_4678981_22	1158345.JNLL01000001_gene1463	1.327e-42	162.0	COG0307@1|root,COG0307@2|Bacteria,2G3ZS@200783|Aquificae	200783|Aquificae	H	riboflavin synthase, alpha subunit	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
CMS2_k127_4678981_10	858215.Thexy_0020	2.571e-81	283.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,42F0T@68295|Thermoanaerobacterales	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
CMS2_k127_4678981_11	1047013.AQSP01000135_gene1597	1.012e-74	263.0	COG0552@1|root,COG0552@2|Bacteria,2NP66@2323|unclassified Bacteria	2|Bacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
CMS2_k127_4678981_39	398720.MED217_10477	8.726e-06	53.0	COG1396@1|root,COG2932@1|root,COG1396@2|Bacteria,COG2932@2|Bacteria,4NQQR@976|Bacteroidetes,1I35C@117743|Flavobacteriia,2XIB5@283735|Leeuwenhoekiella	976|Bacteroidetes	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,Peptidase_S24
CMS2_k127_4678981_20	43989.cce_0520	2.316e-46	176.0	COG0500@1|root,COG2226@2|Bacteria,1GEHX@1117|Cyanobacteria,3KIZ7@43988|Cyanothece	1117|Cyanobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_4678981_2	1185876.BN8_04701	1.911e-190	605.0	COG0500@1|root,COG1215@1|root,COG1215@2|Bacteria,COG2226@2|Bacteria,4NJWI@976|Bacteroidetes,47KMN@768503|Cytophagia	976|Bacteroidetes	MQ	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_23
CMS2_k127_4678981_14	1321779.HMPREF1984_01407	5.31e-62	229.0	COG2148@1|root,COG2148@2|Bacteria,378EQ@32066|Fusobacteria	32066|Fusobacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
CMS2_k127_4678981_28	398512.JQKC01000002_gene1937	1.661e-25	119.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS2_k127_4678981_8	46234.ANA_C10381	1.507e-95	326.0	COG0438@1|root,COG0438@2|Bacteria,1G0TI@1117|Cyanobacteria,1HKVT@1161|Nostocales	1117|Cyanobacteria	M	SPTR Glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
CMS2_k127_4678981_16	1283299.AUKG01000001_gene2234	1.373e-58	222.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,4CP93@84995|Rubrobacteria	84995|Rubrobacteria	GM	sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
CMS2_k127_4678981_37	1379698.RBG1_1C00001G1218	6.67e-12	66.0	COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria	2|Bacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_8
CMS2_k127_4678981_15	395493.BegalDRAFT_0238	4.517e-61	215.0	2DHAE@1|root,2ZYZ6@2|Bacteria,1RERS@1224|Proteobacteria,1SAMG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4276)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4276
CMS2_k127_4678981_1	573370.DMR_16070	3.493e-203	638.0	COG4637@1|root,COG4637@2|Bacteria,1ND40@1224|Proteobacteria,42V9X@68525|delta/epsilon subdivisions,2WSER@28221|Deltaproteobacteria,2MA87@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21
CMS2_k127_4678981_6	1499967.BAYZ01000081_gene1040	5.501e-126	411.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	afr	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_4678981_23	1042376.AFPK01000026_gene2194	1.396e-41	159.0	COG0705@1|root,COG0705@2|Bacteria,4NGT3@976|Bacteroidetes,1HXF0@117743|Flavobacteriia,406HS@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS2_k127_4678981_25	589865.DaAHT2_0362	2.84e-27	116.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,42U6G@68525|delta/epsilon subdivisions,2WQDR@28221|Deltaproteobacteria,2MKIR@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0195	PgpA
CMS2_k127_4678981_9	857293.CAAU_1723	1.376e-83	293.0	COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,36E1K@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
CMS2_k127_4678981_7	1123503.KB908056_gene1875	2.825e-103	351.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,2KG5Y@204458|Caulobacterales	204458|Caulobacterales	C	Dehydrogenase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
CMS2_k127_4678981_3	1288963.ADIS_1920	3.6e-187	591.0	COG4637@1|root,COG4637@2|Bacteria,4NFTD@976|Bacteroidetes,47MI3@768503|Cytophagia	976|Bacteroidetes	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,AAA_21
CMS2_k127_4678981_19	1450525.JATV01000004_gene89	4.79e-49	182.0	2DHAE@1|root,2ZYZ6@2|Bacteria,4NU3B@976|Bacteroidetes	976|Bacteroidetes	S	Domain of unknown function (DUF4276)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4276
CMS2_k127_4678981_35	667014.Thein_1386	2.457e-14	84.0	2A9J6@1|root,2ZY78@2|Bacteria,2GIKB@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4678981_34	667014.Thein_1834	1.364e-14	85.0	2A9J6@1|root,30YRI@2|Bacteria,2GIHT@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4678981_36	43989.cce_1698	4.154e-13	76.0	2AVTU@1|root,31MME@2|Bacteria,1G9HZ@1117|Cyanobacteria,3KI0Y@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4678981_24	1047013.AQSP01000120_gene960	4.611e-40	165.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	prsK	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c
CMS2_k127_4678981_5	56780.SYN_01093	4.589e-126	418.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MRFN@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_4678981_18	41431.PCC8801_2453	1.073e-52	192.0	COG1971@1|root,COG1971@2|Bacteria,1G66H@1117|Cyanobacteria,3KHQS@43988|Cyanothece	1117|Cyanobacteria	C	Probably functions as a manganese efflux pump	mntP	-	-	-	-	-	-	-	-	-	-	-	Mntp
CMS2_k127_4678981_12	1047013.AQSP01000106_gene1773	1.412e-71	259.0	COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4976,Sulfatase
CMS2_k127_4678981_38	509191.AEDB02000072_gene2046	1.2e-08	60.0	2E5T4@1|root,330HF@2|Bacteria,1VGGW@1239|Firmicutes,24RKP@186801|Clostridia,3WK7D@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4678981_0	697284.ERIC2_c18040	0.0	2059.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4716151_0	1499967.BAYZ01000122_gene3376	6.844e-61	228.0	COG1337@1|root,COG1337@2|Bacteria,2NRVQ@2323|unclassified Bacteria	2|Bacteria	L	RAMP superfamily	-	-	-	-	-	-	-	-	-	-	-	-	RAMPs
CMS2_k127_4716151_2	324602.Caur_2276	5.252e-08	61.0	2BEAU@1|root,3281V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4716151_1	742740.HMPREF9474_02113	2.573e-13	75.0	COG1337@1|root,COG1337@2|Bacteria,1UZIC@1239|Firmicutes,24K3J@186801|Clostridia	186801|Clostridia	L	RAMP superfamily	-	-	-	-	-	-	-	-	-	-	-	-	RAMPs
CMS2_k127_4757045_25	1185876.BN8_02203	1.257e-08	60.0	2FBH3@1|root,343NG@2|Bacteria,4P60S@976|Bacteroidetes,47VSN@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4757045_1	1047013.AQSP01000142_gene185	1e-323	1013.0	COG4447@1|root,COG4447@2|Bacteria,2NQ6W@2323|unclassified Bacteria	2|Bacteria	S	Por secretion system C-terminal sorting domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
CMS2_k127_4757045_19	452637.Oter_1909	8.549e-50	191.0	COG3595@1|root,COG3595@2|Bacteria,46W0J@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS2_k127_4757045_17	1047013.AQSP01000106_gene1778	8.313e-53	190.0	COG0824@1|root,COG0824@2|Bacteria	2|Bacteria	IQ	Thioesterase	fcbC2	-	3.1.2.23	ko:K01075	ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120	-	R01301	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	4HBT_2
CMS2_k127_4757045_5	861299.J421_6088	2.484e-134	452.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_4757045_3	1408473.JHXO01000011_gene3046	8.683e-184	589.0	COG3104@1|root,COG3104@2|Bacteria,4NE8R@976|Bacteroidetes,2FNB6@200643|Bacteroidia	976|Bacteroidetes	P	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
CMS2_k127_4757045_6	459349.CLOAM1219	2.094e-128	430.0	COG2957@1|root,COG2957@2|Bacteria	2|Bacteria	E	agmatine deiminase activity	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph,Peptidase_C25,Peptidase_C25_C,Propeptide_C25
CMS2_k127_4757045_21	269799.Gmet_1932	7.687e-38	158.0	COG0457@1|root,COG0457@2|Bacteria,1QXNU@1224|Proteobacteria,43C4R@68525|delta/epsilon subdivisions,2X7F5@28221|Deltaproteobacteria,43SFM@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Peptidase MA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2,TPR_16,TPR_2,TPR_8
CMS2_k127_4757045_2	1047013.AQSP01000138_gene1035	6.767e-204	645.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_4757045_13	1047013.AQSP01000138_gene1034	1.067e-74	258.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	4.6.1.1	ko:K01768,ko:K03713,ko:K11923,ko:K13638	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	MerR_1
CMS2_k127_4757045_20	697281.Mahau_1960	1.396e-48	182.0	COG0500@1|root,COG2226@2|Bacteria,1V6QV@1239|Firmicutes,24JPQ@186801|Clostridia,42HD2@68295|Thermoanaerobacterales	186801|Clostridia	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
CMS2_k127_4757045_4	251229.Chro_4226	5.614e-170	544.0	COG0402@1|root,COG0402@2|Bacteria,1G3XY@1117|Cyanobacteria,3VJD7@52604|Pleurocapsales	1117|Cyanobacteria	F	Amidohydrolase family	-	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
CMS2_k127_4757045_23	234267.Acid_1882	1.173e-12	78.0	2DF1J@1|root,2ZQ4G@2|Bacteria	2|Bacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
CMS2_k127_4757045_16	243274.THEMA_09220	8.583e-70	247.0	COG1131@1|root,COG1131@2|Bacteria,2GC32@200918|Thermotogae	200918|Thermotogae	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_4757045_24	1123023.JIAI01000032_gene4171	1.055e-08	57.0	COG1233@1|root,COG1233@2|Bacteria,2I9K8@201174|Actinobacteria,4E2C6@85010|Pseudonocardiales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
CMS2_k127_4757045_22	517418.Ctha_0156	3.777e-26	115.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
CMS2_k127_4757045_15	28229.ND2E_1925	7.53e-74	257.0	COG2834@1|root,COG2834@2|Bacteria,1R5U8@1224|Proteobacteria,1S5NE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS2_k127_4757045_11	28229.ND2E_1924	8.065e-82	287.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1S1AK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG4591 ABC-type transport system, involved in lipoprotein release, permease component	VPA0558	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_4757045_12	1123228.AUIH01000003_gene917	2.411e-81	285.0	COG4591@1|root,COG4591@2|Bacteria,1PHM4@1224|Proteobacteria,1RXRK@1236|Gammaproteobacteria,1XQ87@135619|Oceanospirillales	135619|Oceanospirillales	M	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS2_k127_4757045_10	1313304.CALK_0753	2.58e-84	285.0	COG1136@1|root,COG1136@2|Bacteria	2|Bacteria	V	lipoprotein transporter activity	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_4757045_18	28229.ND2E_1921	1.761e-51	199.0	2C2F5@1|root,30VYX@2|Bacteria,1MZFF@1224|Proteobacteria,1SB97@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4757045_7	1408473.JHXO01000009_gene3408	1.211e-117	386.0	COG0167@1|root,COG0167@2|Bacteria,4NF4D@976|Bacteroidetes,2FM0X@200643|Bacteroidia	976|Bacteroidetes	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
CMS2_k127_4757045_9	118168.MC7420_1562	1.173e-85	292.0	COG0697@1|root,COG0697@2|Bacteria,1G24W@1117|Cyanobacteria,1H8S0@1150|Oscillatoriales	1117|Cyanobacteria	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS2_k127_4757045_8	313606.M23134_05392	4.974e-117	384.0	COG0388@1|root,COG0388@2|Bacteria,4NGH7@976|Bacteroidetes,47NQU@768503|Cytophagia	976|Bacteroidetes	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
CMS2_k127_4757045_14	509191.AEDB02000003_gene1012	5.104e-74	253.0	arCOG10401@1|root,2ZA7Y@2|Bacteria,1V3TD@1239|Firmicutes,24I7A@186801|Clostridia,3WI8C@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4757045_0	1124780.ANNU01000020_gene3278	0.0	1746.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,47KS7@768503|Cytophagia	976|Bacteroidetes	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
CMS2_k127_4768899_4	1173023.KE650771_gene5201	6.216e-140	464.0	COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,Thioesterase,ketoacyl-synt
CMS2_k127_4768899_1	755731.Clo1100_0890	0.0	1939.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4768899_3	1174528.JH992890_gene591	1.471e-205	660.0	COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria	2|Bacteria	O	carbamoyl transferase, NodU family	nolO	-	-	ko:K00612,ko:K16035	ko01051,ko01052,ko01130,map01051,map01052,map01130	-	R09853,R09858	RC00055,RC02840	ko00000,ko00001,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS2_k127_4768899_0	755731.Clo1100_0890	0.0	2031.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4768899_2	1196323.ALKF01000205_gene4118	2.846e-208	662.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes	1239|Firmicutes	Q	synthase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4839165_0	1174528.JH992890_gene608	0.0	1476.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1JJIN@1189|Stigonemataceae	1117|Cyanobacteria	Q	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_4839165_2	1168034.FH5T_07760	2.753e-35	150.0	COG0793@1|root,COG4206@1|root,COG0793@2|Bacteria,COG4206@2|Bacteria,4NEF4@976|Bacteroidetes,2FVM1@200643|Bacteroidia	976|Bacteroidetes	M	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,PDZ,PDZ_2
CMS2_k127_4839165_1	138119.DSY3651	1.733e-102	350.0	COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,248WN@186801|Clostridia,264RI@186807|Peptococcaceae	186801|Clostridia	C	Na+/H+ antiporter family	-	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
CMS2_k127_4839165_3	32057.KB217478_gene3541	2.355e-28	117.0	COG1846@1|root,COG2319@1|root,COG1846@2|Bacteria,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	GUN4,HTH_24,MarR_2,ROK,RadC
CMS2_k127_4841351_5	673860.AciM339_1462	1.332e-182	587.0	COG3404@1|root,arCOG05394@2157|Archaea,arCOG05395@2157|Archaea,2XX41@28890|Euryarchaeota,3F3A8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Formiminotransferase domain, N-terminal subdomain	-	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
CMS2_k127_4841351_37	796940.HMPREF9628_00691	8.734e-65	228.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,247JF@186801|Clostridia,25QFE@186804|Peptostreptococcaceae	186801|Clostridia	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
CMS2_k127_4841351_69	930171.Asphe3_23490	3.51e-08	61.0	COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,1W99H@1268|Micrococcaceae	201174|Actinobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0008150,GO:0040007	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
CMS2_k127_4841351_57	882.DVU_0838	1.59e-23	102.0	COG1837@1|root,COG1837@2|Bacteria,1N7IX@1224|Proteobacteria,42TXI@68525|delta/epsilon subdivisions,2WQBS@28221|Deltaproteobacteria,2MCGN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the UPF0109 family	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
CMS2_k127_4841351_60	944479.JQLX01000015_gene135	2.278e-20	92.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,42V30@68525|delta/epsilon subdivisions,2WRH7@28221|Deltaproteobacteria,2M7EP@213113|Desulfurellales	28221|Deltaproteobacteria	J	Ribosomal protein S16	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
CMS2_k127_4841351_15	234267.Acid_2573	1.392e-127	421.0	COG0541@1|root,COG0541@2|Bacteria,3Y3AU@57723|Acidobacteria	57723|Acidobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
CMS2_k127_4841351_31	555079.Toce_1032	1.569e-73	269.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,42EW8@68295|Thermoanaerobacterales	186801|Clostridia	KLT	Serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_4841351_14	1047013.AQSP01000109_gene2429	3.249e-134	469.0	COG1196@1|root,COG1196@2|Bacteria,2NNYZ@2323|unclassified Bacteria	2|Bacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529,ko:K10297	-	-	-	-	ko00000,ko03036,ko04121	-	-	-	SMC_N,SMC_hinge
CMS2_k127_4841351_11	573413.Spirs_3800	4.076e-144	473.0	COG0513@1|root,COG0513@2|Bacteria,2J5U7@203691|Spirochaetes	203691|Spirochaetes	JKL	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
CMS2_k127_4841351_63	929703.KE386491_gene1108	3.252e-14	83.0	2DS9A@1|root,33F33@2|Bacteria,4NZAK@976|Bacteroidetes	976|Bacteroidetes	S	Intron encoded nuclease repeat motif	-	-	-	-	-	-	-	-	-	-	-	-	NUMOD1,NUMOD4
CMS2_k127_4841351_18	1232410.KI421413_gene611	2.291e-120	407.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,43S18@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Na+/Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
CMS2_k127_4841351_0	1047013.AQSP01000138_gene1021	8.854e-287	888.0	COG0008@1|root,COG0008@2|Bacteria,2NNRW@2323|unclassified Bacteria	2|Bacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECIAI39_1322.ECIAI39_0637	tRNA-synt_1c,tRNA-synt_1c_C
CMS2_k127_4841351_43	1125863.JAFN01000001_gene2149	2.589e-48	182.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM Rhomboid family	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	DnaJ_C,Rhomboid
CMS2_k127_4841351_21	697303.Thewi_1019	1.605e-113	383.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,42ETH@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
CMS2_k127_4841351_2	926549.KI421517_gene3546	2.258e-257	818.0	COG0188@1|root,COG0188@2|Bacteria,4NDWQ@976|Bacteroidetes,47K30@768503|Cytophagia	976|Bacteroidetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CMS2_k127_4841351_1	1232410.KI421422_gene2032	2.649e-259	822.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,43SYW@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
CMS2_k127_4841351_48	1410612.JNKO01000019_gene122	2.014e-32	139.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia,2PS3W@265975|Oribacterium	186801|Clostridia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
CMS2_k127_4841351_32	1047013.AQSP01000115_gene338	3.354e-71	254.0	COG0592@1|root,COG0592@2|Bacteria,2NP7D@2323|unclassified Bacteria	2|Bacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
CMS2_k127_4841351_25	1410653.JHVC01000020_gene4533	4.14e-88	307.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,36DSQ@31979|Clostridiaceae	186801|Clostridia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
CMS2_k127_4841351_68	1433287.X808_20	2.756e-10	68.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1Y7GJ@135625|Pasteurellales	135625|Pasteurellales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
CMS2_k127_4841351_28	1221537.B807_794	2.668e-82	280.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,4HAYM@91061|Bacilli,3F4AE@33958|Lactobacillaceae	91061|Bacilli	D	Sporulation initiation inhibitor	soj	GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS2_k127_4841351_39	1123376.AUIU01000015_gene430	1.042e-62	226.0	COG1475@1|root,COG1475@2|Bacteria,3J0K9@40117|Nitrospirae	40117|Nitrospirae	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
CMS2_k127_4841351_50	1047013.AQSP01000133_gene2159	2.314e-29	121.0	COG1664@1|root,COG1664@2|Bacteria,2NQ1N@2323|unclassified Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin,zf-HC2
CMS2_k127_4841351_41	1218173.BALCAV_0213535	2.823e-52	193.0	COG1212@1|root,COG1212@2|Bacteria,1TQU3@1239|Firmicutes,4IRPK@91061|Bacilli,1ZRWE@1386|Bacillus	91061|Bacilli	M	Cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_3
CMS2_k127_4841351_4	1158345.JNLL01000001_gene320	2.271e-210	666.0	COG0504@1|root,COG0504@2|Bacteria,2G3KJ@200783|Aquificae	200783|Aquificae	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
CMS2_k127_4841351_6	1191523.MROS_1169	7.579e-157	503.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS2_k127_4841351_70	247633.GP2143_00482	6.263e-08	54.0	2DRA2@1|root,33AVQ@2|Bacteria,1NKZA@1224|Proteobacteria,1SH2Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4841351_42	1545915.JROG01000011_gene26	4.051e-52	195.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,2TUFR@28211|Alphaproteobacteria,2KB4V@204457|Sphingomonadales	204457|Sphingomonadales	S	Creatinine amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Creatininase
CMS2_k127_4841351_8	596324.TREVI0001_0376	1.013e-152	501.0	COG0018@1|root,COG0018@2|Bacteria,2J5EP@203691|Spirochaetes	203691|Spirochaetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
CMS2_k127_4841351_36	317619.ANKN01000153_gene1867	7.34e-66	228.0	COG0328@1|root,COG0328@2|Bacteria,1GEDE@1117|Cyanobacteria,1MKTT@1212|Prochloraceae	1117|Cyanobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
CMS2_k127_4841351_66	1469607.KK073768_gene4829	1.076e-11	70.0	COG1950@1|root,COG1950@2|Bacteria,1G7RB@1117|Cyanobacteria,1HNVQ@1161|Nostocales	1117|Cyanobacteria	S	PFAM Membrane protein of	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
CMS2_k127_4841351_67	1396141.BATP01000060_gene4670	1.068e-10	69.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	HEAT_2,PT-HINT,T2SSE_N
CMS2_k127_4841351_40	1379698.RBG1_1C00001G0801	7.774e-56	216.0	COG0457@1|root,COG0457@2|Bacteria,2NPK1@2323|unclassified Bacteria	2|Bacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
CMS2_k127_4841351_7	1279009.ADICEAN_03081	4.781e-153	522.0	COG1074@1|root,COG1074@2|Bacteria,4NEX4@976|Bacteroidetes,47KES@768503|Cytophagia	976|Bacteroidetes	L	Belongs to the helicase family. UvrD subfamily	addA	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas4,PDDEXK_1,UvrD-helicase,UvrD_C
CMS2_k127_4841351_9	435591.BDI_1187	8.36e-151	511.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,4NFZQ@976|Bacteroidetes,2FN03@200643|Bacteroidia,22W74@171551|Porphyromonadaceae	976|Bacteroidetes	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
CMS2_k127_4841351_47	1499967.BAYZ01000077_gene851	1.8e-34	137.0	COG5573@1|root,COG5573@2|Bacteria	2|Bacteria	K	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_4841351_64	1410625.JHWK01000010_gene2033	6.423e-13	74.0	COG4103@1|root,COG4103@2|Bacteria	2|Bacteria	T	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB,TerB_N
CMS2_k127_4841351_71	1280663.ATVR01000039_gene1347	7.783e-07	59.0	COG0500@1|root,COG2226@2|Bacteria,1UVT3@1239|Firmicutes,25B9E@186801|Clostridia,4BY9J@830|Butyrivibrio	186801|Clostridia	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_4841351_23	1131269.AQVV01000013_gene1767	1.451e-97	337.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_4841351_26	1047013.AQSP01000144_gene809	2.009e-87	297.0	COG1215@1|root,COG1215@2|Bacteria,2NQUG@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_4841351_27	313606.M23134_07914	2.868e-85	289.0	COG1215@1|root,COG1215@2|Bacteria,4NF0S@976|Bacteroidetes,47KDC@768503|Cytophagia	976|Bacteroidetes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_4841351_58	1499967.BAYZ01000158_gene458	5.613e-23	115.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_22,PMT_2
CMS2_k127_4841351_17	1191523.MROS_2005	2.713e-122	448.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4841351_38	1250005.PHEL85_3226	1.995e-64	256.0	COG4886@1|root,COG4886@2|Bacteria,4NI2K@976|Bacteroidetes,1I0CI@117743|Flavobacteriia,3VX1T@52959|Polaribacter	976|Bacteroidetes	S	Leucine rich repeat	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,Ig_3,LRR_4,LRR_6,LRR_8
CMS2_k127_4841351_65	751944.HALDL1_03910	1.18e-12	85.0	arCOG02540@1|root,arCOG04500@1|root,arCOG10954@1|root,arCOG02540@2157|Archaea,arCOG04500@2157|Archaea,arCOG10954@2157|Archaea,2XWGB@28890|Euryarchaeota,23UX2@183963|Halobacteria	183963|Halobacteria	M	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4841351_20	1444711.CCJF01000005_gene546	2.886e-115	425.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta,SBBP
CMS2_k127_4841351_24	1499967.BAYZ01000096_gene4315	2.593e-92	332.0	COG0421@1|root,COG0421@2|Bacteria,2NNTV@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
CMS2_k127_4841351_62	203122.Sde_0908	1.95e-15	84.0	COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,1S3XT@1236|Gammaproteobacteria,4675S@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
CMS2_k127_4841351_56	246194.CHY_1118	2.716e-24	117.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia,42GD1@68295|Thermoanaerobacterales	186801|Clostridia	S	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
CMS2_k127_4841351_59	880072.Desac_1386	1.461e-21	104.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	mauD	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	AhpC-TSA,Thioredoxin,Thioredoxin_2
CMS2_k127_4841351_19	1185876.BN8_06618	8.911e-116	398.0	COG0308@1|root,COG0308@2|Bacteria,4NEXH@976|Bacteroidetes,47JGQ@768503|Cytophagia	976|Bacteroidetes	E	PFAM Peptidase M1, membrane alanine aminopeptidase	-	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M1
CMS2_k127_4841351_16	1158338.JNLJ01000001_gene868	4.952e-124	406.0	COG1087@1|root,COG1087@2|Bacteria,2G3QB@200783|Aquificae	200783|Aquificae	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS2_k127_4841351_52	1033802.SSPSH_000617	6.383e-29	118.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	RNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS2_k127_4841351_55	1499967.BAYZ01000090_gene4950	6.179e-28	125.0	COG0392@1|root,COG0392@2|Bacteria,2NPJC@2323|unclassified Bacteria	2|Bacteria	S	Lysylphosphatidylglycerol synthase TM region	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS2_k127_4841351_44	1047013.AQSP01000132_gene1719	8.443e-48	186.0	COG4942@1|root,COG4942@2|Bacteria,2NPDY@2323|unclassified Bacteria	2|Bacteria	D	Peptidase family M23	envC	GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
CMS2_k127_4841351_54	224324.aq_797	1.302e-28	129.0	COG0793@1|root,COG0793@2|Bacteria,2G3RT@200783|Aquificae	200783|Aquificae	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
CMS2_k127_4841351_49	1499967.BAYZ01000027_gene1800	8.115e-32	139.0	COG2861@1|root,COG2861@2|Bacteria,2NPU5@2323|unclassified Bacteria	2|Bacteria	S	Divergent polysaccharide deacetylase	yibQ	-	-	ko:K09798	-	-	-	-	ko00000	-	-	-	Polysacc_deac_2
CMS2_k127_4841351_3	1047013.AQSP01000142_gene243	1.055e-241	765.0	COG0326@1|root,COG0326@2|Bacteria,2NNZY@2323|unclassified Bacteria	2|Bacteria	O	Molecular chaperone. Has ATPase activity	htpG	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071450,GO:0071451,GO:0071944,GO:1901700,GO:1901701	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
CMS2_k127_4841351_53	1121914.AUDW01000002_gene870	1.161e-28	124.0	COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,4HCF5@91061|Bacilli,3WEQV@539002|Bacillales incertae sedis	91061|Bacilli	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
CMS2_k127_4841351_12	1047013.AQSP01000071_gene1935	3.156e-141	478.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,2NNKI@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
CMS2_k127_4841351_33	1047013.AQSP01000071_gene1934	7.189e-70	250.0	COG0772@1|root,COG0772@2|Bacteria,2NNRP@2323|unclassified Bacteria	2|Bacteria	D	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
CMS2_k127_4841351_13	1047013.AQSP01000071_gene1933	9.501e-136	453.0	COG0768@1|root,COG0768@2|Bacteria,2NNYI@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-binding protein 2	mrdA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928,iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604	PBP_dimer,Transpeptidase
CMS2_k127_4841351_51	1047013.AQSP01000071_gene1931	2.83e-29	127.0	COG1792@1|root,COG1792@2|Bacteria,2NPNX@2323|unclassified Bacteria	2|Bacteria	M	Cell shape-determining protein MreC	mreC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0030428,GO:0031224,GO:0031226,GO:0042546,GO:0043621,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944,GO:0071963	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
CMS2_k127_4841351_10	1267533.KB906733_gene3086	2.516e-146	470.0	COG1077@1|root,COG1077@2|Bacteria,3Y3VC@57723|Acidobacteria,2JHQ2@204432|Acidobacteriia	204432|Acidobacteriia	D	cell shape determining protein MreB	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
CMS2_k127_4841351_30	641491.DND132_0278	1.118e-75	260.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,42QRC@68525|delta/epsilon subdivisions,2WMP7@28221|Deltaproteobacteria,2M9ZR@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
CMS2_k127_4841351_29	395493.BegalDRAFT_2025	8.849e-77	276.0	COG4395@1|root,COG4395@2|Bacteria,1NKJZ@1224|Proteobacteria,1SU45@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tim44	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4841351_61	395493.BegalDRAFT_2024	3.092e-17	89.0	COG3762@1|root,COG3762@2|Bacteria	2|Bacteria	S	Membrane	Z012_08985	-	-	ko:K08988	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
CMS2_k127_4841351_45	326427.Cagg_1115	1.591e-44	172.0	2EU2Z@1|root,33MJU@2|Bacteria,2G8PR@200795|Chloroflexi,3778I@32061|Chloroflexia	32061|Chloroflexia	H	PFAM ribosomal RNA methyltransferase	-	-	2.1.1.179	ko:K18845	-	-	-	-	br01600,ko00000,ko01000,ko01504,ko03009	-	-	-	FmrO
CMS2_k127_4841351_22	82654.Pse7367_1026	4.825e-110	366.0	COG0343@1|root,COG0343@2|Bacteria,1G0EV@1117|Cyanobacteria,1H81I@1150|Oscillatoriales	2|Bacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	-	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
CMS2_k127_4841351_34	82654.Pse7367_1025	3.19e-69	243.0	COG0313@1|root,COG0313@2|Bacteria,1G0IF@1117|Cyanobacteria,1H7AW@1150|Oscillatoriales	1117|Cyanobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
CMS2_k127_4841351_35	1047013.AQSP01000140_gene2483	3.188e-67	239.0	COG0275@1|root,COG0275@2|Bacteria,2NP8Y@2323|unclassified Bacteria	2|Bacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
CMS2_k127_4841351_46	760192.Halhy_3247	7.437e-37	148.0	COG1680@1|root,COG1680@2|Bacteria,4NFUI@976|Bacteroidetes,1INWP@117747|Sphingobacteriia	976|Bacteroidetes	V	COGs COG1680 Beta-lactamase class C and other penicillin binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
CMS2_k127_4854626_31	316274.Haur_4768	1.039e-17	98.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2G790@200795|Chloroflexi,375DF@32061|Chloroflexia	32061|Chloroflexia	T	SMART protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,SpoIIE
CMS2_k127_4854626_24	177437.HRM2_03860	5.344e-31	133.0	COG3183@1|root,COG3183@2|Bacteria,1MZRA@1224|Proteobacteria,42W8N@68525|delta/epsilon subdivisions,2WRC6@28221|Deltaproteobacteria,2MMFK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	HNH nucleases	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HNH
CMS2_k127_4854626_4	443254.Marpi_0436	5.835e-133	434.0	COG1373@1|root,COG1373@2|Bacteria,2GCQH@200918|Thermotogae	200918|Thermotogae	S	AAA domain	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14
CMS2_k127_4854626_29	639282.DEFDS_2016	4.156e-18	94.0	COG2253@1|root,COG2253@2|Bacteria	2|Bacteria	V	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS2_k127_4854626_21	1340493.JNIF01000003_gene1477	2.956e-44	177.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	ko:K20333	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	FGE-sulfatase,NACHT
CMS2_k127_4854626_8	1121904.ARBP01000010_gene2247	2.777e-112	397.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,4NHCZ@976|Bacteroidetes,47XH8@768503|Cytophagia	976|Bacteroidetes	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_7,TPR_8
CMS2_k127_4854626_39	1340493.JNIF01000004_gene552	2.303e-05	58.0	2EXAB@1|root,33QKZ@2|Bacteria,3Y6WS@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4854626_27	1340493.JNIF01000004_gene733	1.296e-20	105.0	COG2304@1|root,COG2304@2|Bacteria,3Y6C6@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
CMS2_k127_4854626_18	1192034.CAP_2007	2.482e-50	193.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42N75@68525|delta/epsilon subdivisions,2WKJY@28221|Deltaproteobacteria,2Z2YT@29|Myxococcales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
CMS2_k127_4854626_36	1291050.JAGE01000001_gene1266	3.231e-10	74.0	COG4447@1|root,COG4447@2|Bacteria,1UU3Y@1239|Firmicutes,24C6F@186801|Clostridia,3WMYB@541000|Ruminococcaceae	186801|Clostridia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4854626_33	1123326.JFBL01000022_gene2603	5.657e-16	92.0	COG1846@1|root,COG1846@2|Bacteria,1NTRY@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4854626_25	1449335.JQLG01000004_gene1223	1.259e-25	116.0	COG2076@1|root,COG2076@2|Bacteria,1TRP3@1239|Firmicutes,4HCX9@91061|Bacilli,27FGP@186828|Carnobacteriaceae	91061|Bacilli	P	Small Multidrug Resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	EamA,Multi_Drug_Res
CMS2_k127_4854626_15	385682.AFSL01000035_gene2978	4.653e-64	228.0	COG1235@1|root,COG1235@2|Bacteria,4NDVI@976|Bacteroidetes,2FN8Y@200643|Bacteroidia,3XJIS@558415|Marinilabiliaceae	976|Bacteroidetes	S	Beta-lactamase superfamily domain	vicX	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
CMS2_k127_4854626_7	240015.ACP_2445	3.723e-122	416.0	COG0568@1|root,COG0568@2|Bacteria,3Y2XG@57723|Acidobacteria,2JHX1@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS2_k127_4854626_9	1047013.AQSP01000113_gene754	2.048e-102	355.0	COG0358@1|root,COG0358@2|Bacteria,2NNNJ@2323|unclassified Bacteria	2|Bacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
CMS2_k127_4854626_30	1047013.AQSP01000084_gene765	7.99e-18	91.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
CMS2_k127_4854626_6	1047013.AQSP01000128_gene437	1.558e-122	406.0	COG0044@1|root,COG0044@2|Bacteria,2NNWP@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
CMS2_k127_4854626_2	96561.Dole_0377	8.568e-181	579.0	COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria	1224|Proteobacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
CMS2_k127_4854626_22	273068.TTE2627	7.986e-40	154.0	2CA4A@1|root,32RQK@2|Bacteria,1VE2U@1239|Firmicutes,24QHD@186801|Clostridia,42GU9@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF4416)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4416
CMS2_k127_4854626_38	868864.Dester_1275	1.589e-05	58.0	COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,2G407@200783|Aquificae	200783|Aquificae	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
CMS2_k127_4854626_16	338969.Rfer_1133	2.884e-54	203.0	COG0530@1|root,COG0530@2|Bacteria,1PW8G@1224|Proteobacteria,2VMK4@28216|Betaproteobacteria,4AJD4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS2_k127_4854626_14	1047013.AQSP01000119_gene1291	1.995e-67	239.0	COG0061@1|root,COG0061@2|Bacteria,2NP7T@2323|unclassified Bacteria	2|Bacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895	NAD_kinase
CMS2_k127_4854626_19	316067.Geob_3047	1.905e-48	183.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,42R2J@68525|delta/epsilon subdivisions,2WIJ6@28221|Deltaproteobacteria,43S7C@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
CMS2_k127_4854626_17	1121333.JMLH01000003_gene273	1.791e-50	188.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,3VP1V@526524|Erysipelotrichia	526524|Erysipelotrichia	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
CMS2_k127_4854626_37	391625.PPSIR1_16975	7.245e-08	59.0	28Y1X@1|root,2ZJXH@2|Bacteria,1R3P3@1224|Proteobacteria	1224|Proteobacteria	S	YEATS family	-	-	-	-	-	-	-	-	-	-	-	-	YEATS
CMS2_k127_4854626_20	1304885.AUEY01000002_gene316	1.803e-47	198.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42YGZ@68525|delta/epsilon subdivisions,2WU75@28221|Deltaproteobacteria,2MMN6@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg
CMS2_k127_4854626_0	1499967.BAYZ01000009_gene5313	4.981e-242	802.0	COG0642@1|root,COG2202@1|root,COG3292@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,COG4191@2|Bacteria,2NNZT@2323|unclassified Bacteria	2|Bacteria	T	Two component regulator propeller	-	-	-	ko:K17763	-	-	-	-	ko00000,ko03021	-	-	-	GAF_2,GGDEF,HATPase_c,HD_5,HisKA,PAS,PAS_3,PAS_4,PAS_9,Reg_prop,Response_reg,STAS,Y_Y_Y
CMS2_k127_4854626_13	1220534.B655_0710	1.891e-78	268.0	COG4912@1|root,arCOG11010@2157|Archaea,2XWKG@28890|Euryarchaeota,23PIX@183925|Methanobacteria	183925|Methanobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
CMS2_k127_4854626_11	616991.JPOO01000003_gene393	8.825e-93	318.0	COG1914@1|root,COG1914@2|Bacteria,4NENE@976|Bacteroidetes,1HXXF@117743|Flavobacteriia	976|Bacteroidetes	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	-	-	-	-	-	-	-	-	-	Nramp
CMS2_k127_4854626_1	1047013.AQSP01000055_gene270	1.886e-196	625.0	COG0146@1|root,COG0146@2|Bacteria	2|Bacteria	EQ	ligase activity	hyuB	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01474	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0266c	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
CMS2_k127_4854626_3	123214.PERMA_1472	9.918e-175	569.0	COG0145@1|root,COG0145@2|Bacteria,2G3PK@200783|Aquificae	200783|Aquificae	EQ	Hydantoinase/oxoprolinase N-terminal region	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
CMS2_k127_4854626_10	224324.aq_1117	2.809e-100	342.0	COG2204@1|root,COG2204@2|Bacteria,2G3T9@200783|Aquificae	200783|Aquificae	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_4854626_28	1291050.JAGE01000001_gene2007	5.007e-19	101.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,3WGAH@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
CMS2_k127_4854626_23	1121438.JNJA01000004_gene924	2.601e-37	163.0	COG2984@1|root,COG3852@1|root,COG4191@1|root,COG2984@2|Bacteria,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MHBV@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
CMS2_k127_4854626_5	1121104.AQXH01000001_gene1459	1.836e-129	450.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,4NRVM@976|Bacteroidetes,1IQDC@117747|Sphingobacteriia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
CMS2_k127_4854626_12	666686.B1NLA3E_15165	9.201e-86	293.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,1ZDBF@1386|Bacillus	91061|Bacilli	L	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS2_k127_4854626_34	1121403.AUCV01000073_gene1306	1.519e-11	74.0	COG1345@1|root,COG1572@1|root,COG1345@2|Bacteria,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	ko:K02396,ko:K13276	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02035,ko03110	-	-	-	Flg_bbr_C,Peptidase_S8,TMP_2,VCBS
CMS2_k127_4874121_2	272134.KB731325_gene778	4.544e-07	54.0	COG3599@1|root,COG3599@2|Bacteria,1GG7D@1117|Cyanobacteria	1117|Cyanobacteria	D	regulation of cell shape	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4874121_0	313606.M23134_05981	3.918e-46	177.0	COG4123@1|root,COG4123@2|Bacteria,4NKPF@976|Bacteroidetes,47SG7@768503|Cytophagia	976|Bacteroidetes	S	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
CMS2_k127_4874121_1	56780.SYN_01128	4.851e-35	137.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MTX@68525|delta/epsilon subdivisions	1224|Proteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_48842_0	1052684.PPM_4401	0.0	1674.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	pmxA	-	-	ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_48842_1	1196323.ALKF01000205_gene4116	3.371e-114	420.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_4884954_0	1123257.AUFV01000011_gene3138	5.265e-51	190.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RPMP@1236|Gammaproteobacteria,1X4MM@135614|Xanthomonadales	135614|Xanthomonadales	O	peptidylprolyl	-	-	5.2.1.8	ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
CMS2_k127_4884954_2	1168034.FH5T_15070	2.288e-05	53.0	2FJRB@1|root,34BE7@2|Bacteria,4P5QR@976|Bacteroidetes,2FYTE@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4884954_1	324925.Ppha_2424	1.897e-20	100.0	2EDYH@1|root,337TB@2|Bacteria,1FEFX@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_489831_0	1237149.C900_04816	7.778e-231	764.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47TR0@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Response_reg,Y_Y_Y
CMS2_k127_489831_1	1047013.AQSP01000139_gene2323	9.059e-80	279.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_4934813_44	313606.M23134_00105	7.279e-55	217.0	COG1649@1|root,COG3291@1|root,COG4733@1|root,COG1649@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,4NJK3@976|Bacteroidetes,47TYM@768503|Cytophagia	976|Bacteroidetes	E	Pregnancy-associated plasma protein-A	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_M43
CMS2_k127_4934813_11	1499967.BAYZ01000080_gene926	2.292e-121	416.0	COG2234@1|root,COG2234@2|Bacteria,2NQ2F@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS2_k127_4934813_18	332101.JIBU02000025_gene3243	1.26e-106	352.0	COG0697@1|root,COG0697@2|Bacteria,1UAMA@1239|Firmicutes,24B3H@186801|Clostridia,36HYJ@31979|Clostridiaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS2_k127_4934813_4	945713.IALB_0837	5.032e-167	536.0	COG1972@1|root,COG1972@2|Bacteria	2|Bacteria	F	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family	yeiM	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
CMS2_k127_4934813_10	1307761.L21SP2_1605	3.457e-131	430.0	COG1816@1|root,COG1816@2|Bacteria,2J9QW@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Adenosine AMP deaminase	-	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
CMS2_k127_4934813_31	349521.HCH_03840	2.565e-73	252.0	COG2236@1|root,COG2236@2|Bacteria,1MXS1@1224|Proteobacteria,1RPSD@1236|Gammaproteobacteria,1XJDA@135619|Oceanospirillales	135619|Oceanospirillales	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
CMS2_k127_4934813_34	926569.ANT_19710	1.156e-68	239.0	COG0572@1|root,COG0572@2|Bacteria,2G6D5@200795|Chloroflexi	200795|Chloroflexi	F	Cytidine monophosphokinase	udk	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
CMS2_k127_4934813_58	1123371.ATXH01000004_gene1717	1.496e-21	101.0	COG0454@1|root,COG0456@2|Bacteria,2GHSZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
CMS2_k127_4934813_55	1047013.AQSP01000140_gene2455	1.155e-32	136.0	COG1214@1|root,COG1214@2|Bacteria,2NPK8@2323|unclassified Bacteria	2|Bacteria	O	Glycoprotease family	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CMS2_k127_4934813_62	931276.Cspa_c50680	1.137e-11	71.0	COG2172@1|root,COG2172@2|Bacteria,1VMMN@1239|Firmicutes,25MYN@186801|Clostridia,36KVF@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
CMS2_k127_4934813_67	1095743.HMPREF1054_2056	3.172e-06	57.0	COG2932@1|root,COG2932@2|Bacteria,1RBQ6@1224|Proteobacteria,1S2AF@1236|Gammaproteobacteria,1Y8PB@135625|Pasteurellales	135625|Pasteurellales	K	This gene contains a nucleotide ambiguity which may be the result of a sequencing error	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_Tnp_Mu_1,Peptidase_S24
CMS2_k127_4934813_43	1353529.M899_3479	6.559e-55	198.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,42RGU@68525|delta/epsilon subdivisions,2MT3K@213481|Bdellovibrionales,2WPHH@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
CMS2_k127_4934813_21	439235.Dalk_0237	2.25e-103	377.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_4934813_9	247490.KSU1_C0714	2.943e-137	481.0	COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes	203682|Planctomycetes	O	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
CMS2_k127_4934813_69	379066.GAU_0039	3.156e-05	56.0	COG3391@1|root,COG3391@2|Bacteria,1ZU68@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4934813_68	379066.GAU_0039	3.624e-06	59.0	COG3391@1|root,COG3391@2|Bacteria,1ZU68@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4934813_1	880073.Calab_2175	7.974e-207	662.0	COG0488@1|root,COG0488@2|Bacteria,2NNPH@2323|unclassified Bacteria	2|Bacteria	S	ABC transporter	yheS	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
CMS2_k127_4934813_46	335543.Sfum_1123	1.001e-51	204.0	2E7E8@1|root,331X9@2|Bacteria,1NB1R@1224|Proteobacteria,42WG3@68525|delta/epsilon subdivisions,2WS1D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3943)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3943
CMS2_k127_4934813_12	665571.STHERM_c16310	8.995e-120	392.0	COG0330@1|root,COG0330@2|Bacteria,2J5A8@203691|Spirochaetes	203691|Spirochaetes	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
CMS2_k127_4934813_26	665571.STHERM_c16320	6.747e-91	309.0	COG0330@1|root,COG0330@2|Bacteria,2J5TU@203691|Spirochaetes	203691|Spirochaetes	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
CMS2_k127_4934813_24	748449.Halha_1408	6.614e-96	327.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,3WA8M@53433|Halanaerobiales	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_4934813_53	1047013.AQSP01000083_gene1197	2.292e-36	145.0	COG1386@1|root,COG1386@2|Bacteria,2NPPM@2323|unclassified Bacteria	2|Bacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
CMS2_k127_4934813_54	289376.THEYE_A0360	9.379e-36	145.0	COG1354@1|root,COG1354@2|Bacteria,3J13J@40117|Nitrospirae	40117|Nitrospirae	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
CMS2_k127_4934813_41	1047013.AQSP01000083_gene1194	4.805e-58	209.0	COG1994@1|root,COG1994@2|Bacteria,2NPQP@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	ywhC	-	-	ko:K06402	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M50
CMS2_k127_4934813_45	1379698.RBG1_1C00001G0342	7.962e-54	198.0	COG2908@1|root,COG2908@2|Bacteria,2NPKW@2323|unclassified Bacteria	2|Bacteria	S	Calcineurin-like phosphoesterase	lpxH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iE2348C_1286.E2348C_0457	Metallophos,Metallophos_2
CMS2_k127_4934813_30	1499967.BAYZ01000181_gene4506	1.512e-73	254.0	COG2197@1|root,COG2197@2|Bacteria,2NPMZ@2323|unclassified Bacteria	2|Bacteria	T	helix_turn_helix, Lux Regulon	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
CMS2_k127_4934813_37	1499967.BAYZ01000181_gene4505	2.117e-64	235.0	COG4585@1|root,COG5002@1|root,COG4585@2|Bacteria,COG5002@2|Bacteria,2NPMD@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GGDEF,HAMP,HATPase_c,HisKA_3,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg
CMS2_k127_4934813_47	1047013.AQSP01000133_gene2163	8.599e-51	186.0	COG1778@1|root,COG1778@2|Bacteria,2NPJJ@2323|unclassified Bacteria	2|Bacteria	S	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	kdsC	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
CMS2_k127_4934813_22	1047013.AQSP01000133_gene2162	2.922e-100	336.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,2NNNB@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	2.5.1.55,5.3.1.13	ko:K01627,ko:K03281,ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530,R03254	RC00435,RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	2.A.49	-	iAF987.Gmet_1278	CBS,SIS
CMS2_k127_4934813_25	667014.Thein_1397	1.026e-92	311.0	COG2877@1|root,COG2877@2|Bacteria,2GH7U@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	DAHP synthetase I family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
CMS2_k127_4934813_6	1047013.AQSP01000135_gene1626	1.505e-159	530.0	COG1674@1|root,COG1674@2|Bacteria,2NNVB@2323|unclassified Bacteria	2|Bacteria	D	Ftsk_gamma	ftsK	GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
CMS2_k127_4934813_32	1121405.dsmv_3733	6.649e-73	250.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,42SXB@68525|delta/epsilon subdivisions,2WPMK@28221|Deltaproteobacteria,2MKWB@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS2_k127_4934813_7	880073.Calab_1667	9.897e-148	490.0	COG1757@1|root,COG1757@2|Bacteria,2NPD8@2323|unclassified Bacteria	2|Bacteria	C	Na+/H+ antiporter family	nhaC	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
CMS2_k127_4934813_14	1128912.GMES_0176	6.764e-117	398.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
CMS2_k127_4934813_20	1379698.RBG1_1C00001G0370	4.531e-104	359.0	COG0616@1|root,COG0616@2|Bacteria,2NNKU@2323|unclassified Bacteria	2|Bacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
CMS2_k127_4934813_57	634498.mru_0504	2.098e-25	114.0	COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,23P1X@183925|Methanobacteria	183925|Methanobacteria	J	Sua5 YciO YrdC YwlC	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
CMS2_k127_4934813_52	1499967.BAYZ01000095_gene4129	5.477e-39	168.0	COG0705@1|root,COG0705@2|Bacteria,2NPGI@2323|unclassified Bacteria	2|Bacteria	S	(Rhomboid) family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS2_k127_4934813_33	1047013.AQSP01000135_gene1560	4.83e-69	244.0	COG2006@1|root,COG2006@2|Bacteria,2NPBD@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,TAT_signal
CMS2_k127_4934813_16	589865.DaAHT2_0700	9.906e-114	385.0	COG0348@1|root,COG1143@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,1MY5M@1224|Proteobacteria,43BPV@68525|delta/epsilon subdivisions,2WJVS@28221|Deltaproteobacteria,2MPI2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_7
CMS2_k127_4934813_48	344747.PM8797T_30444	2.817e-48	185.0	COG0705@1|root,COG0705@2|Bacteria,2IZJ7@203682|Planctomycetes	203682|Planctomycetes	S	Rhomboid family	-	-	-	ko:K02441	-	-	-	-	ko00000	-	-	-	Rhomboid,Rhomboid_N
CMS2_k127_4934813_38	1304874.JAFY01000002_gene597	2.664e-62	218.0	COG0778@1|root,COG0778@2|Bacteria,3TB6G@508458|Synergistetes	508458|Synergistetes	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS2_k127_4934813_40	56780.SYN_00684	4.732e-59	208.0	COG4119@1|root,COG4119@2|Bacteria,1RHCE@1224|Proteobacteria,431WB@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS2_k127_4934813_39	880073.Calab_3797	4.603e-60	226.0	COG2208@1|root,COG3292@1|root,COG2208@2|Bacteria,COG3292@2|Bacteria,2NNZT@2323|unclassified Bacteria	2|Bacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,HisKA_2,HisKA_3,PAS_9,Reg_prop,Response_reg,SpoIIE,Y_Y_Y
CMS2_k127_4934813_3	1439940.BAY1663_02227	2.405e-167	544.0	COG1861@1|root,COG2089@1|root,COG1861@2|Bacteria,COG2089@2|Bacteria,1RG42@1224|Proteobacteria,1S57I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog	-	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3
CMS2_k127_4934813_19	586413.CCDL010000001_gene1477	1.353e-105	368.0	28H8D@1|root,2Z7KA@2|Bacteria,1UB21@1239|Firmicutes,4HA47@91061|Bacilli,23J54@182709|Oceanobacillus	91061|Bacilli	-	-	ykoS	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4934813_28	419665.Maeo_0420	6.761e-84	290.0	COG2089@1|root,arCOG01050@2157|Archaea,2XTT7@28890|Euryarchaeota,23Q74@183939|Methanococci	183939|Methanococci	H	SAF	-	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
CMS2_k127_4934813_56	240302.BN982_01197	5.984e-28	125.0	COG3153@1|root,COG3153@2|Bacteria,1V0I4@1239|Firmicutes,4HCMH@91061|Bacilli,3NDUK@45667|Halobacillus	91061|Bacilli	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
CMS2_k127_4934813_59	944479.JQLX01000014_gene1596	9.852e-19	92.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,42URG@68525|delta/epsilon subdivisions,2WNDG@28221|Deltaproteobacteria,2M78R@213113|Desulfurellales	28221|Deltaproteobacteria	E	Glyoxalase-like domain	mceE	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
CMS2_k127_4934813_27	345219.Bcoa_0728	1.032e-84	300.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HEG0@91061|Bacilli,1ZDWY@1386|Bacillus	91061|Bacilli	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
CMS2_k127_4934813_50	309799.DICTH_0748	4.717e-44	169.0	COG0483@1|root,COG0483@2|Bacteria	2|Bacteria	G	inositol monophosphate 1-phosphatase activity	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P,NUDIX
CMS2_k127_4934813_13	411902.CLOBOL_06424	2.149e-119	392.0	COG1995@1|root,COG1995@2|Bacteria,1TQGT@1239|Firmicutes,24A12@186801|Clostridia,21YY0@1506553|Lachnoclostridium	186801|Clostridia	C	Pyridoxal phosphate biosynthetic protein PdxA	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
CMS2_k127_4934813_65	1280682.AUKA01000007_gene3100	4.443e-08	58.0	COG0236@1|root,COG0236@2|Bacteria,1VGGM@1239|Firmicutes,24Q2V@186801|Clostridia,4C27A@830|Butyrivibrio	186801|Clostridia	IQ	Phosphopantetheine attachment site	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CMS2_k127_4934813_2	1096769.Pelub83DRAFT_0709	1.974e-173	562.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,2U6XU@28211|Alphaproteobacteria,4BR86@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS2_k127_4934813_23	760142.Hipma_1643	3.639e-99	327.0	COG2120@1|root,COG2120@2|Bacteria,1MUTM@1224|Proteobacteria,42Q20@68525|delta/epsilon subdivisions,2WP8Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
CMS2_k127_4934813_64	478749.BRYFOR_08234	2.976e-10	68.0	COG2207@1|root,COG2207@2|Bacteria,1UZ0N@1239|Firmicutes,24GNF@186801|Clostridia	186801|Clostridia	K	transcriptional regulator (AraC family)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS2_k127_4934813_0	471854.Dfer_1607	6.947e-209	700.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47TR0@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Response_reg,Y_Y_Y
CMS2_k127_4934813_66	445971.ANASTE_01324	2.613e-07	61.0	COG1246@1|root,COG1246@2|Bacteria,1TRN6@1239|Firmicutes,2484V@186801|Clostridia,25VKA@186806|Eubacteriaceae	186801|Clostridia	E	YoaP-like	yoaP	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,YoaP
CMS2_k127_4934813_49	1089550.ATTH01000001_gene1852	6.22e-47	172.0	COG0251@1|root,COG0251@2|Bacteria,4NPT2@976|Bacteroidetes	976|Bacteroidetes	J	PFAM Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,Ribonuc_L-PSP
CMS2_k127_4934813_8	886293.Sinac_7402	4.103e-142	485.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG3850@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3850@2|Bacteria,2IXFD@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
CMS2_k127_4934813_51	330214.NIDE0544	3.919e-40	161.0	COG2984@1|root,COG2984@2|Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
CMS2_k127_4934813_5	443143.GM18_2644	2.696e-162	534.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42PWS@68525|delta/epsilon subdivisions,2WKI5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TPR_8,TonB_dep_Rec
CMS2_k127_4934813_63	1235457.C404_17545	1.17e-10	70.0	28R8P@1|root,2ZDNC@2|Bacteria,1PBH5@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4934813_35	933262.AXAM01000002_gene504	1.568e-66	250.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria,2MI6A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
CMS2_k127_4934813_42	706587.Desti_3526	3.804e-56	203.0	COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria,42TT9@68525|delta/epsilon subdivisions,2X6GK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Ergosterol biosynthesis ERG4/ERG24 family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4934813_61	749927.AMED_7830	1.925e-16	94.0	COG3291@1|root,COG3291@2|Bacteria,2I41P@201174|Actinobacteria	201174|Actinobacteria	G	Carbohydrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_4_9
CMS2_k127_4934813_60	880073.Calab_1754	9.012e-18	98.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.4,3.4.21.66	ko:K01179,ko:K08651	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH5,GH9	-	Autotransporter,PKD,Peptidase_S8,Peptidase_S8_N,fn3
CMS2_k127_4934813_17	1499967.BAYZ01000080_gene926	1.119e-112	389.0	COG2234@1|root,COG2234@2|Bacteria,2NQ2F@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS2_k127_4934813_36	269797.Mbar_A1802	9.96e-66	256.0	COG1520@1|root,arCOG02550@1|root,arCOG03991@1|root,arCOG02482@2157|Archaea,arCOG02550@2157|Archaea,arCOG03991@2157|Archaea,2XUI1@28890|Euryarchaeota,2NBKV@224756|Methanomicrobia	224756|Methanomicrobia	G	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NosD,PKD,PQQ_2,PQQ_3
CMS2_k127_4934813_15	1499967.BAYZ01000080_gene926	2.98e-115	410.0	COG2234@1|root,COG2234@2|Bacteria,2NQ2F@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS2_k127_4934813_29	1122947.FR7_3334	7.275e-81	282.0	COG3949@1|root,COG3949@2|Bacteria,1TSC0@1239|Firmicutes,4H98R@909932|Negativicutes	909932|Negativicutes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4953540_0	96561.Dole_3250	4.276e-166	533.0	COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
CMS2_k127_4953540_5	314278.NB231_00530	3.992e-28	129.0	COG0500@1|root,COG0500@2|Bacteria,1R53Q@1224|Proteobacteria,1SMCT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4953540_1	1121405.dsmv_3165	6.779e-120	404.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PDY@68525|delta/epsilon subdivisions,2WMD0@28221|Deltaproteobacteria,2MPRX@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
CMS2_k127_4953540_2	1121438.JNJA01000007_gene1667	1.586e-115	389.0	COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria,1R6YN@1224|Proteobacteria,42Q4G@68525|delta/epsilon subdivisions,2WJM9@28221|Deltaproteobacteria,2M947@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM Metal-dependent hydrolase HDOD	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Response_reg
CMS2_k127_4953540_3	644282.Deba_0043	2.394e-110	368.0	COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,42R6F@68525|delta/epsilon subdivisions,2WN2B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,Response_reg
CMS2_k127_4953540_8	247490.KSU1_D0355	3.092e-08	56.0	COG0467@1|root,COG0467@2|Bacteria,2IZBF@203682|Planctomycetes	203682|Planctomycetes	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
CMS2_k127_4953540_7	702450.CUW_2851	5.012e-14	80.0	COG1996@1|root,COG1996@2|Bacteria,1UZSK@1239|Firmicutes,3VQM6@526524|Erysipelotrichia	526524|Erysipelotrichia	K	This gene contains a nucleotide ambiguity which may be the result of a sequencing error	-	-	-	-	-	-	-	-	-	-	-	-	DUF4379
CMS2_k127_4953540_4	1121405.dsmv_1358	2.939e-30	122.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,42W2F@68525|delta/epsilon subdivisions,2WRUM@28221|Deltaproteobacteria,2MKSW@213118|Desulfobacterales	28221|Deltaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	ihfA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS2_k127_4953540_6	933262.AXAM01000037_gene886	1.432e-26	115.0	COG2204@1|root,COG2204@2|Bacteria,1QWNE@1224|Proteobacteria,43BTE@68525|delta/epsilon subdivisions,2X746@28221|Deltaproteobacteria,2MPJR@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
CMS2_k127_4953902_12	1303518.CCALI_00669	1.936e-23	113.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Glyco_tranf_2_3,Glycos_transf_2,Sulfatase
CMS2_k127_4953902_8	330214.NIDE0304	5.756e-83	293.0	COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,3J11K@40117|Nitrospirae	40117|Nitrospirae	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS2_k127_4953902_6	1499967.BAYZ01000055_gene4856	4.654e-89	298.0	COG0745@1|root,COG0745@2|Bacteria,2NP9R@2323|unclassified Bacteria	2|Bacteria	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_4953902_1	1121405.dsmv_2611	0.0	1013.0	COG0603@1|root,COG1402@1|root,COG0603@2|Bacteria,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2X9RQ@28221|Deltaproteobacteria,2MPA0@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
CMS2_k127_4953902_4	1121405.dsmv_2609	8.904e-154	493.0	COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,42PSH@68525|delta/epsilon subdivisions,2WJYZ@28221|Deltaproteobacteria,2MIFM@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
CMS2_k127_4953902_3	1121405.dsmv_2608	7.545e-156	499.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	-	-	2.5.1.76,4.2.3.1	ko:K01733,ko:K15527	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,PALP
CMS2_k127_4953902_7	436308.Nmar_1003	3.763e-86	292.0	COG3741@1|root,arCOG08266@2157|Archaea	2157|Archaea	E	N-formylglutamate amidohydrolase	-	-	3.5.3.8	ko:K01479	ko00340,ko01100,map00340,map01100	M00045	R02285	RC00221,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	FGase
CMS2_k127_4953902_2	123214.PERMA_1251	8.239e-197	628.0	COG0405@1|root,COG0405@2|Bacteria,2G3M5@200783|Aquificae	2|Bacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CMS2_k127_4953902_10	1168034.FH5T_09600	2.166e-71	251.0	COG0697@1|root,COG0697@2|Bacteria,4NNBQ@976|Bacteroidetes,2FMN9@200643|Bacteroidia	976|Bacteroidetes	EG	Psort location CytoplasmicMembrane, score 10.00	eamA	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS2_k127_4953902_13	768670.Calni_1142	5.586e-11	67.0	COG1672@1|root,COG1672@2|Bacteria,2GG9F@200930|Deferribacteres	200930|Deferribacteres	S	ATPase domain predominantly from Archaea	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2,DUF234
CMS2_k127_4953902_11	247490.KSU1_B0291	1.571e-37	150.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
CMS2_k127_4953902_9	247490.KSU1_B0290	1.393e-75	263.0	COG0515@1|root,COG0515@2|Bacteria,2IXP6@203682|Planctomycetes	203682|Planctomycetes	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_4953902_5	247490.KSU1_B0289	1.19e-128	422.0	28MGF@1|root,2ZATP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4953902_0	1121121.KB894285_gene81	0.0	1533.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_4959664_2	324925.Ppha_2424	4.042e-17	90.0	2EDYH@1|root,337TB@2|Bacteria,1FEFX@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4959664_0	1232410.KI421421_gene3694	4.301e-52	193.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,42QU4@68525|delta/epsilon subdivisions,2WMRQ@28221|Deltaproteobacteria,43SHI@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase	-	-	5.2.1.8	ko:K03772,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
CMS2_k127_4959664_1	324925.Ppha_2425	1.864e-19	94.0	2E9II@1|root,333RI@2|Bacteria,1FEZP@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5040138_0	1047013.AQSP01000135_gene1581	2.176e-72	271.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2NP4I@2323|unclassified Bacteria	2|Bacteria	U	Metallo-beta-lactamase superfamily	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
CMS2_k127_504257_2	1042163.BRLA_c025640	1.333e-227	732.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_504257_0	1009370.ALO_00935	0.0	1826.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_504257_1	1196323.ALKF01000205_gene4116	0.0	1122.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_505733_2	373903.Hore_14410	6.922e-169	555.0	COG0021@1|root,COG0021@2|Bacteria,1TPIB@1239|Firmicutes,25E6C@186801|Clostridia,3WAZ7@53433|Halanaerobiales	186801|Clostridia	G	Belongs to the transketolase family	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
CMS2_k127_505733_18	445972.ANACOL_04298	4.517e-61	215.0	COG1014@1|root,COG1014@2|Bacteria,1V3ZJ@1239|Firmicutes,24HAX@186801|Clostridia,3WK38@541000|Ruminococcaceae	186801|Clostridia	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
CMS2_k127_505733_23	264732.Moth_0377	4.869e-29	119.0	COG1144@1|root,COG1144@2|Bacteria,1VK3X@1239|Firmicutes,24TKS@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
CMS2_k127_505733_3	264732.Moth_0378	1.003e-164	527.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,42EUF@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
CMS2_k127_505733_6	264732.Moth_0379	9.153e-111	366.0	COG1013@1|root,COG1013@2|Bacteria,1TPF0@1239|Firmicutes,24BE5@186801|Clostridia,42F9H@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Thiamine pyrophosphate	-	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00170,ko:K19071	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
CMS2_k127_505733_4	1291050.JAGE01000001_gene1444	1.903e-152	493.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,25MBR@186801|Clostridia,3WNE2@541000|Ruminococcaceae	186801|Clostridia	EK	Alanine-glyoxylate amino-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS2_k127_505733_5	1265505.ATUG01000001_gene4313	1.178e-146	470.0	COG5598@1|root,COG5598@2|Bacteria,1N18H@1224|Proteobacteria,43BDY@68525|delta/epsilon subdivisions,2X6SF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
CMS2_k127_505733_20	1265505.ATUG01000001_gene4312	5.197e-49	179.0	COG5598@1|root,COG5598@2|Bacteria,1NY0Q@1224|Proteobacteria,430P1@68525|delta/epsilon subdivisions,2WVPQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
CMS2_k127_505733_8	1236689.MMALV_11370	6.877e-102	344.0	arCOG06710@1|root,arCOG06710@2157|Archaea,2XTBU@28890|Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the transfer of a methyl group from dimethylamine to the corrinoid cofactor of MtbC	mtbB3	-	2.1.1.249	ko:K16178	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09999,R10015	RC00035,RC00556,RC01144,RC02986	ko00000,ko00001,ko00002,ko01000	-	-	-	Dimeth_Pyl
CMS2_k127_505733_22	1094980.Mpsy_1701	8.713e-36	138.0	arCOG06710@1|root,arCOG06710@2157|Archaea,2Y4CG@28890|Euryarchaeota,2NB25@224756|Methanomicrobia	224756|Methanomicrobia	H	Dimethylamine methyltransferase (Dimeth_PyL)	-	-	2.1.1.249	ko:K16178	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09999,R10015	RC00035,RC00556,RC01144,RC02986	ko00000,ko00001,ko00002,ko01000	-	-	-	Dimeth_Pyl
CMS2_k127_505733_17	1265505.ATUG01000002_gene2502	9.879e-70	242.0	COG5012@1|root,COG5012@2|Bacteria,1PXII@1224|Proteobacteria,42UWK@68525|delta/epsilon subdivisions,2X5FM@28221|Deltaproteobacteria,2MNRC@213118|Desulfobacterales	28221|Deltaproteobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
CMS2_k127_505733_16	1191523.MROS_2095	4.568e-70	249.0	COG0646@1|root,COG0646@2|Bacteria	2|Bacteria	E	methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
CMS2_k127_505733_14	880073.Calab_1882	1.909e-73	256.0	COG1387@1|root,COG1387@2|Bacteria,2NPQX@2323|unclassified Bacteria	2|Bacteria	E	PHP domain	hisK	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP,PHP_C
CMS2_k127_505733_9	755732.Fluta_2601	4.814e-95	318.0	COG4555@1|root,COG4555@2|Bacteria,4PNSV@976|Bacteroidetes,1IKBA@117743|Flavobacteriia,2PBF9@246874|Cryomorphaceae	976|Bacteroidetes	CP	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	3.6.3.7	ko:K09697	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.115	-	-	ABC_tran
CMS2_k127_505733_12	1089550.ATTH01000002_gene87	1.102e-81	286.0	COG1668@1|root,COG1668@2|Bacteria,4NMG0@976|Bacteroidetes	976|Bacteroidetes	CP	ABC-2 family transporter protein	-	-	-	ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	ABC2_membrane_2,ABC2_membrane_3
CMS2_k127_505733_21	1047013.AQSP01000128_gene444	8.837e-49	186.0	2CK1R@1|root,32V4M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_505733_19	1304284.L21TH_0554	2.6e-58	213.0	COG0834@1|root,COG0834@2|Bacteria,1TT16@1239|Firmicutes,24CEZ@186801|Clostridia,36EZP@31979|Clostridiaceae	186801|Clostridia	ET	Belongs to the bacterial solute-binding protein 3 family	artP	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
CMS2_k127_505733_10	653733.Selin_2070	8.255e-85	287.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
CMS2_k127_505733_7	880072.Desac_1865	4.127e-105	349.0	COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria,42NYF@68525|delta/epsilon subdivisions,2WIT2@28221|Deltaproteobacteria,2MQSH@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
CMS2_k127_505733_11	1173028.ANKO01000250_gene2392	5.801e-82	275.0	COG5018@1|root,COG5018@2|Bacteria,1G654@1117|Cyanobacteria,1HB8A@1150|Oscillatoriales	1117|Cyanobacteria	L	Exonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
CMS2_k127_505733_24	382464.ABSI01000001_gene4248	6.229e-26	113.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin,Thioredoxin_7
CMS2_k127_505733_0	1047013.AQSP01000138_gene1075	5.17e-316	999.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrB1	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS2_k127_505733_15	1047013.AQSP01000138_gene1076	1.079e-70	252.0	COG0845@1|root,COG0845@2|Bacteria,2NPS3@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
CMS2_k127_505733_13	1047013.AQSP01000138_gene1077	1.803e-78	281.0	COG1538@1|root,COG1538@2|Bacteria,2NPKK@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_505733_1	666685.R2APBS1_2404	1.135e-251	787.0	COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,1RN63@1236|Gammaproteobacteria,1X47X@135614|Xanthomonadales	135614|Xanthomonadales	L	EcoEI R protein C-terminal	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,HSDR_N_2,Helicase_C,ResIII
CMS2_k127_5079915_0	394503.Ccel_0858	9.76e-247	794.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13612	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_5079915_1	1121890.AUDO01000030_gene1018	3.752e-81	277.0	COG1192@1|root,COG1192@2|Bacteria,4NFEX@976|Bacteroidetes,1HXYG@117743|Flavobacteriia,2NYWA@237|Flavobacterium	976|Bacteroidetes	D	Cellulose biosynthesis protein BcsQ	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
CMS2_k127_5084029_0	1047013.AQSP01000123_gene1545	6.303e-252	842.0	COG2373@1|root,COG2373@2|Bacteria,2NQA2@2323|unclassified Bacteria	2|Bacteria	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1,Thiol-ester_cl
CMS2_k127_5084029_1	63737.Npun_F1222	6.135e-72	260.0	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1HINJ@1161|Nostocales	1117|Cyanobacteria	L	PFAM WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
CMS2_k127_5090081_0	177437.HRM2_34080	1.89e-59	233.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,1N26H@1224|Proteobacteria,43EV4@68525|delta/epsilon subdivisions,2WR4K@28221|Deltaproteobacteria,2MNP4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS2_k127_5090081_3	216595.PFLU_1879	5.666e-15	89.0	COG1409@1|root,COG1409@2|Bacteria,1NC0C@1224|Proteobacteria,1SJ9S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_5090081_1	385682.AFSL01000035_gene2979	1.262e-32	135.0	2CM5E@1|root,2ZTCA@2|Bacteria,4NS4F@976|Bacteroidetes,2FYR1@200643|Bacteroidia,3XKBG@558415|Marinilabiliaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5090081_4	1047013.AQSP01000114_gene683	1.409e-09	70.0	COG0286@1|root,COG0286@2|Bacteria,2NQG4@2323|unclassified Bacteria	2|Bacteria	V	N-6 DNA Methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
CMS2_k127_5090081_6	398512.JQKC01000025_gene3148	0.0001023	50.0	2DM1Y@1|root,31DHT@2|Bacteria,1V8RE@1239|Firmicutes,24KFD@186801|Clostridia,3WJBN@541000|Ruminococcaceae	186801|Clostridia	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS2_k127_5090081_5	1123372.AUIT01000008_gene615	2.067e-06	55.0	COG1396@1|root,33NRJ@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5090081_2	1209984.BN978_04074	3.137e-20	102.0	COG3209@1|root,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria,23EHB@1762|Mycobacteriaceae	201174|Actinobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
CMS2_k127_5093063_8	1047013.AQSP01000138_gene1045	7.511e-57	218.0	COG0613@1|root,COG0613@2|Bacteria,2NPWD@2323|unclassified Bacteria	2|Bacteria	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
CMS2_k127_5093063_10	1547445.LO80_02595	4.144e-56	209.0	COG0438@1|root,COG0438@2|Bacteria,1PGXJ@1224|Proteobacteria,1RXHZ@1236|Gammaproteobacteria,463CJ@72273|Thiotrichales	72273|Thiotrichales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_5093063_7	1469948.JPNB01000002_gene4064	8.862e-64	229.0	COG1089@1|root,COG1089@2|Bacteria,1UP3Y@1239|Firmicutes,25H66@186801|Clostridia,36V96@31979|Clostridiaceae	186801|Clostridia	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	GDP_Man_Dehyd
CMS2_k127_5093063_4	1047013.AQSP01000138_gene1041	3.177e-101	357.0	COG1452@1|root,COG1452@2|Bacteria,2NPN2@2323|unclassified Bacteria	2|Bacteria	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0009279,GO:0015267,GO:0015288,GO:0015749,GO:0015750,GO:0015751,GO:0015757,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0034219,GO:0044462,GO:0044464,GO:0046323,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1904659	-	ko:K04744,ko:K09774,ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2,1.B.42.1	-	iAF987.Gmet_2474,iECO111_1330.ECO111_4695,iECSF_1327.ECSF_3725,iEcSMS35_1347.EcSMS35_4260	KdgM,OstA,OstA_2,OstA_C
CMS2_k127_5093063_3	56780.SYN_00357	2.203e-109	371.0	COG1351@1|root,COG1351@2|Bacteria,1QF4I@1224|Proteobacteria,43A0P@68525|delta/epsilon subdivisions,2X9Q1@28221|Deltaproteobacteria,2MSCD@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Thymidylate synthase complementing protein	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
CMS2_k127_5093063_1	714943.Mucpa_1246	3.873e-158	508.0	COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,1IP7S@117747|Sphingobacteriia	976|Bacteroidetes	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_5093063_18	886293.Sinac_1596	6.912e-09	59.0	COG0236@1|root,COG0236@2|Bacteria,2J1MP@203682|Planctomycetes	203682|Planctomycetes	IQ	acyl carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
CMS2_k127_5093063_0	247490.KSU1_D0742	2.023e-191	614.0	COG0365@1|root,COG0365@2|Bacteria,2IX5P@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
CMS2_k127_5093063_13	1444309.JAQG01000019_gene567	1.916e-41	163.0	COG0688@1|root,COG0688@2|Bacteria,1TR34@1239|Firmicutes,4HB6I@91061|Bacilli,26QJB@186822|Paenibacillaceae	91061|Bacilli	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
CMS2_k127_5093063_11	880073.Calab_3023	1.699e-47	177.0	COG0526@1|root,COG0526@2|Bacteria,2NS00@2323|unclassified Bacteria	2|Bacteria	CO	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_9
CMS2_k127_5093063_5	1237149.C900_05795	1.691e-79	272.0	COG3208@1|root,COG3208@2|Bacteria,4NPE6@976|Bacteroidetes	976|Bacteroidetes	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioesterase
CMS2_k127_5093063_17	565033.GACE_0080	2.702e-15	79.0	COG2442@1|root,arCOG07520@2157|Archaea,2Y1HG@28890|Euryarchaeota,247BI@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
CMS2_k127_5093063_21	693661.Arcve_0573	1.119e-05	52.0	arCOG07904@1|root,arCOG07904@2157|Archaea,2Y64I@28890|Euryarchaeota,247D8@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5093063_23	929562.Emtol_3367	4.977e-05	55.0	COG0308@1|root,COG0308@2|Bacteria,4NG5Q@976|Bacteroidetes,47JW1@768503|Cytophagia	976|Bacteroidetes	E	Peptidase M1, membrane alanine aminopeptidase	pepN1	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M1
CMS2_k127_5093063_20	555779.Dthio_PD0738	1.234e-06	53.0	2EQ2A@1|root,33HNQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5093063_16	1499967.BAYZ01000041_gene2350	2.699e-19	93.0	COG1848@1|root,COG1848@2|Bacteria,2NRZH@2323|unclassified Bacteria	2|Bacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_5093063_14	944480.ATUV01000001_gene1257	6.223e-40	161.0	COG5464@1|root,COG5464@2|Bacteria,1MUSP@1224|Proteobacteria,42RIE@68525|delta/epsilon subdivisions,2WNU1@28221|Deltaproteobacteria,2M7M5@213113|Desulfurellales	28221|Deltaproteobacteria	S	Putative transposase, YhgA-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
CMS2_k127_5093063_24	1304880.JAGB01000002_gene2182	0.0004585	44.0	COG4894@1|root,COG4894@2|Bacteria,1V3WA@1239|Firmicutes,24MB0@186801|Clostridia	186801|Clostridia	S	LURP-one-related	-	-	-	-	-	-	-	-	-	-	-	-	LOR
CMS2_k127_5093063_9	65393.PCC7424_4250	1.105e-56	211.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
CMS2_k127_5093063_12	118163.Ple7327_1131	7.299e-46	177.0	28JA5@1|root,3216P@2|Bacteria,1GBP0@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5093063_2	521045.Kole_0614	1.959e-157	519.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	ko:K06889,ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase,Malectin,Peptidase_S9
CMS2_k127_5093063_15	1047013.AQSP01000033_gene1394	2.993e-20	91.0	COG0828@1|root,COG0828@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
CMS2_k127_5093063_6	1047013.AQSP01000098_gene2560	3.708e-67	245.0	COG3359@1|root,COG3359@2|Bacteria,2NPCP@2323|unclassified Bacteria	2|Bacteria	L	RNase_H superfamily	yprB	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
CMS2_k127_5103746_0	471854.Dfer_1718	1.716e-41	155.0	COG2337@1|root,COG2337@2|Bacteria,4NTCI@976|Bacteroidetes,47RQE@768503|Cytophagia	976|Bacteroidetes	L	Toxic component of a toxin-antitoxin (TA) module	chpA	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
CMS2_k127_5112355_0	358681.BBR47_39840	5.461e-193	640.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HUE5@91061|Bacilli,26VP1@186822|Paenibacillaceae	91061|Bacilli	Q	Pfam:HxxPF_rpt	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Condensation,Methyltransf_12,NAD_binding_4,PP-binding
CMS2_k127_5112355_1	1284352.AOIG01000015_gene4223	1.207e-180	603.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5113642_9	515635.Dtur_1285	9.975e-17	94.0	COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PPC,Peptidase_M8,Peptidase_S8,SLH
CMS2_k127_5113642_2	439235.Dalk_0237	9.332e-91	323.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_5113642_7	247633.GP2143_16736	3.223e-39	154.0	COG2928@1|root,COG2928@2|Bacteria,1RF26@1224|Proteobacteria,1S579@1236|Gammaproteobacteria,1J60W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
CMS2_k127_5113642_6	386456.JQKN01000007_gene3315	8.096e-40	163.0	COG2208@1|root,arCOG06893@2157|Archaea,2Y2MD@28890|Euryarchaeota,23PHZ@183925|Methanobacteria	183925|Methanobacteria	T	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,SpoIIE
CMS2_k127_5113642_3	555088.DealDRAFT_2730	2.618e-63	224.0	COG1878@1|root,COG1878@2|Bacteria,1TSXB@1239|Firmicutes,24B80@186801|Clostridia	186801|Clostridia	S	PFAM cyclase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
CMS2_k127_5113642_5	1410653.JHVC01000012_gene2295	2.734e-53	199.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,36E02@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
CMS2_k127_5113642_1	247490.KSU1_D0010	2.855e-115	422.0	COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes	203682|Planctomycetes	O	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
CMS2_k127_5113642_8	1250232.JQNJ01000001_gene1018	1.354e-21	113.0	COG3656@1|root,COG4886@1|root,COG3656@2|Bacteria,COG4886@2|Bacteria,4NR6Y@976|Bacteroidetes,1I2WF@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM Receptor L domain	-	-	-	-	-	-	-	-	-	-	-	-	ASH
CMS2_k127_5113642_0	1191523.MROS_2005	9.625e-159	562.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5113642_10	880073.Calab_0696	1.341e-08	70.0	COG1262@1|root,COG2911@1|root,COG3055@1|root,COG3934@1|root,COG5492@1|root,COG1262@2|Bacteria,COG2911@2|Bacteria,COG3055@2|Bacteria,COG3934@2|Bacteria,COG5492@2|Bacteria,2NPU7@2323|unclassified Bacteria	2|Bacteria	G	Sulfatase-modifying factor enzyme 1	-	-	3.2.1.1,3.2.1.51,3.2.1.78,3.2.1.81,3.2.1.89	ko:K01176,ko:K01206,ko:K01218,ko:K01219,ko:K01224	ko00051,ko00500,ko00511,ko01100,ko02024,ko04973,map00051,map00500,map00511,map01100,map02024,map04973	-	R01332,R02108,R02112,R11262	RC00467	ko00000,ko00001,ko01000,ko04147	-	GH13,GH26,GH29	-	Big_2,DctA-YdbH,FGE-sulfatase
CMS2_k127_5113642_4	5722.XP_001312173.1	8.975e-62	239.0	COG0666@1|root,KOG4177@2759|Eukaryota	2759|Eukaryota	I	spectrin binding	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
CMS2_k127_5114247_4	431943.CKL_2354	3.265e-117	395.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36QT1@31979|Clostridiaceae	186801|Clostridia	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_31,NAD_binding_4,PP-binding,ketoacyl-synt
CMS2_k127_5114247_6	439235.Dalk_0237	4.797e-104	372.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_5114247_2	1499967.BAYZ01000080_gene935	8.086e-124	431.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Pectate_lyase_3
CMS2_k127_5114247_0	690850.Desaf_0617	4.271e-234	749.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2M7U6@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K01338,ko:K04076,ko:K04770	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Lon_C
CMS2_k127_5114247_9	335543.Sfum_0887	2.462e-75	265.0	2B96C@1|root,322HH@2|Bacteria,1NT78@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5114247_16	694427.Palpr_0869	3.031e-27	117.0	COG0484@1|root,COG0484@2|Bacteria,4P0AH@976|Bacteroidetes,2FYI2@200643|Bacteroidia	976|Bacteroidetes	C	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5114247_7	1408473.JHXO01000005_gene1865	2.83e-100	340.0	COG0484@1|root,COG0484@2|Bacteria,4NPS0@976|Bacteroidetes,2FXKU@200643|Bacteroidia	976|Bacteroidetes	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5114247_13	264732.Moth_1961	2.907e-43	164.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,42I67@68295|Thermoanaerobacterales	186801|Clostridia	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
CMS2_k127_5114247_8	338969.Rfer_0863	2.012e-84	306.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHII@28216|Betaproteobacteria,4AJXE@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding	-	-	1.3.99.16	ko:K00256	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS2_k127_5114247_24	436717.AOLE_04700	2.902e-12	79.0	COG0457@1|root,COG0457@2|Bacteria,1NXTH@1224|Proteobacteria,1SQ9H@1236|Gammaproteobacteria,3NJ1V@468|Moraxellaceae	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
CMS2_k127_5114247_5	1205683.CAKR01000043_gene4351	4.322e-117	387.0	COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,1RPNC@1236|Gammaproteobacteria,41FFR@629|Yersinia	1236|Gammaproteobacteria	M	Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues	wecB	GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008761,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046378,GO:0071704,GO:1901135,GO:1901137,GO:1901576	3.2.1.183,5.1.3.14	ko:K01791,ko:K08068	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iECOK1_1307.ECOK1_4232,iECS88_1305.ECS88_4208,iECs_1301.ECs4719,iEcSMS35_1347.EcSMS35_4150,iG2583_1286.G2583_4580,iPC815.YPO3864,iSDY_1059.SDY_3962,iSSON_1240.SSON_3958,iUMN146_1321.UM146_19070,iZ_1308.Z5297	Epimerase_2
CMS2_k127_5114247_19	1173026.Glo7428_3540	2.301e-23	117.0	COG3170@1|root,COG3170@2|Bacteria,1G0I0@1117|Cyanobacteria	1117|Cyanobacteria	NU	PFAM Bacterial cellulose synthase subunit	-	-	-	ko:K20541	-	-	-	-	ko00000,ko02000	4.D.3.1.6	-	-	BcsB
CMS2_k127_5114247_3	1121434.AULY01000007_gene1229	6.371e-123	422.0	COG1215@1|root,COG1215@2|Bacteria,1P7GR@1224|Proteobacteria,43D6S@68525|delta/epsilon subdivisions,2X8DM@28221|Deltaproteobacteria,2MACQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM General secretory system II protein E domain protein	-	-	-	ko:K11740	-	-	-	-	ko00000	-	-	-	Glyco_trans_2_3,T2SSE_N
CMS2_k127_5114247_14	1408422.JHYF01000006_gene1030	4.216e-41	164.0	COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,25CN4@186801|Clostridia,36WY7@31979|Clostridiaceae	186801|Clostridia	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
CMS2_k127_5114247_18	511995.CFPG_635	5.743e-24	110.0	COG0204@1|root,COG0204@2|Bacteria,4NG5R@976|Bacteroidetes,2FMJG@200643|Bacteroidia	976|Bacteroidetes	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS2_k127_5114247_23	1499967.BAYZ01000100_gene3454	4.801e-13	72.0	2EVWS@1|root,33PAF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5114247_11	1499967.BAYZ01000100_gene3454	1.902e-51	188.0	2EVWS@1|root,33PAF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5114247_22	748727.CLJU_c21130	5.898e-22	104.0	2EEYU@1|root,338S2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5114247_15	1123399.AQVE01000004_gene2692	2.222e-28	120.0	2DQW5@1|root,32UPY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5114247_21	573061.Clocel_4074	6.62e-23	108.0	2DQW5@1|root,32UPY@2|Bacteria,1V507@1239|Firmicutes,24IKH@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5114247_12	1336235.JAEG01000006_gene681	3.504e-46	175.0	2EEYU@1|root,338S2@2|Bacteria,1RGAV@1224|Proteobacteria,2U8V9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5114247_10	1173028.ANKO01000215_gene6244	2.246e-66	247.0	COG0457@1|root,COG0457@2|Bacteria,1G2BQ@1117|Cyanobacteria,1H9YM@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_6,TPR_8
CMS2_k127_5114247_17	179408.Osc7112_1957	5.848e-27	127.0	COG1595@1|root,COG1595@2|Bacteria,1G687@1117|Cyanobacteria,1HB9J@1150|Oscillatoriales	1117|Cyanobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_5114247_20	521460.Athe_2638	3.57e-23	107.0	COG1848@1|root,COG1848@2|Bacteria,1VBKR@1239|Firmicutes,24JHN@186801|Clostridia	186801|Clostridia	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_5114247_1	7425.NV15300-PA	6.142e-153	503.0	COG0519@1|root,KOG1622@2759|Eukaryota,38DHS@33154|Opisthokonta,3BDTV@33208|Metazoa,3CW4N@33213|Bilateria,41TJK@6656|Arthropoda,3SJCG@50557|Insecta,46GX7@7399|Hymenoptera	33208|Metazoa	F	GMP synthase C terminal domain	GMPS	GO:0000902,GO:0000904,GO:0001101,GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005700,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006163,GO:0006164,GO:0006177,GO:0006325,GO:0006464,GO:0006508,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0006935,GO:0006996,GO:0007275,GO:0007399,GO:0007409,GO:0007411,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009605,GO:0009653,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010604,GO:0010952,GO:0016043,GO:0016504,GO:0016569,GO:0016570,GO:0016578,GO:0016579,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019899,GO:0022008,GO:0030030,GO:0030154,GO:0030162,GO:0030182,GO:0030234,GO:0031175,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032989,GO:0032990,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0035800,GO:0036211,GO:0040011,GO:0042221,GO:0042278,GO:0042330,GO:0042440,GO:0042451,GO:0042455,GO:0042493,GO:0043085,GO:0043170,GO:0043200,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046037,GO:0046112,GO:0046128,GO:0046129,GO:0046148,GO:0046390,GO:0046483,GO:0048468,GO:0048518,GO:0048522,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051276,GO:0051336,GO:0051345,GO:0052547,GO:0055086,GO:0060255,GO:0061134,GO:0061564,GO:0065007,GO:0065009,GO:0070646,GO:0070647,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097485,GO:0098772,GO:0120036,GO:0120039,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901367,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1901698,GO:1901700,GO:2000152,GO:2000158	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
CMS2_k127_5121722_1	315730.BcerKBAB4_1784	4.46e-163	537.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	ko:K15654,ko:K15655,ko:K15662,ko:K15663,ko:K16093,ko:K16095	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
CMS2_k127_5121722_12	391165.GbCGDNIH1_0443	3e-05	56.0	COG2227@1|root,COG2227@2|Bacteria,1QW6H@1224|Proteobacteria,2TRBZ@28211|Alphaproteobacteria,2JYXG@204441|Rhodospirillales	204441|Rhodospirillales	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_25
CMS2_k127_5121722_7	1121861.KB899932_gene27	6e-40	164.0	COG2227@1|root,COG2227@2|Bacteria,1QW6H@1224|Proteobacteria,2TRBZ@28211|Alphaproteobacteria,2JYXG@204441|Rhodospirillales	204441|Rhodospirillales	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_25
CMS2_k127_5121722_6	1122247.C731_2752	2.931e-46	177.0	COG3340@1|root,COG3340@2|Bacteria,2IC7Y@201174|Actinobacteria,234WT@1762|Mycobacteriaceae	201174|Actinobacteria	E	Peptidase family S51	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
CMS2_k127_5121722_5	1094508.Tsac_1386	2.022e-54	199.0	COG2091@1|root,COG2091@2|Bacteria,1VEYZ@1239|Firmicutes,24RQ3@186801|Clostridia,42GYT@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the P-Pant transferase superfamily	sfp	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
CMS2_k127_5121722_3	1237149.C900_05795	8.35e-80	273.0	COG3208@1|root,COG3208@2|Bacteria,4NPE6@976|Bacteroidetes	976|Bacteroidetes	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioesterase
CMS2_k127_5121722_0	204669.Acid345_1151	8.294e-172	562.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria,2JIBK@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
CMS2_k127_5121722_2	1121011.AUCB01000006_gene1017	3.038e-160	520.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1I0X7@117743|Flavobacteriia,23FWQ@178469|Arenibacter	976|Bacteroidetes	E	Sodium:solute symporter family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_5121722_9	655815.ZPR_2499	3.223e-06	51.0	2E97G@1|root,333FY@2|Bacteria,4NWTY@976|Bacteroidetes,1I5KD@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5121722_4	1047013.AQSP01000106_gene1773	8.475e-56	221.0	COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4976,Sulfatase
CMS2_k127_5121722_11	471854.Dfer_3682	8.418e-06	55.0	COG4914@1|root,COG4914@2|Bacteria,4NTDW@976|Bacteroidetes,47XU6@768503|Cytophagia	976|Bacteroidetes	S	Nucleotidyl transferase of unknown function (DUF2204)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204
CMS2_k127_5122897_6	864563.HMPREF9166_1126	9.541e-113	416.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_5122897_0	1009370.ALO_00935	0.0	1441.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_5122897_4	398512.JQKC01000015_gene4632	1.319e-156	504.0	COG0826@1|root,COG0826@2|Bacteria,1VT61@1239|Firmicutes,24AZY@186801|Clostridia,3WRXE@541000|Ruminococcaceae	186801|Clostridia	O	Peptidase family U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
CMS2_k127_5122897_2	398512.JQKC01000015_gene4635	2.218e-208	679.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WH7Q@541000|Ruminococcaceae	186801|Clostridia	Q	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_5122897_1	1196323.ALKF01000205_gene4114	0.0	1258.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_5122897_3	251229.Chro_0078	4.803e-204	676.0	COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1G0XE@1117|Cyanobacteria,3VM88@52604|Pleurocapsales	1117|Cyanobacteria	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5122897_5	1121015.N789_06345	5.997e-151	506.0	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria,1X4WG@135614|Xanthomonadales	135614|Xanthomonadales	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_5122897_7	289376.THEYE_A1734	8.254e-44	179.0	COG0476@1|root,COG0476@2|Bacteria	2|Bacteria	H	Involved in molybdopterin and thiamine biosynthesis, family 2	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
CMS2_k127_5122897_8	1174528.JH992893_gene6034	7.437e-19	101.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria	1117|Cyanobacteria	Q	Amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5123966_3	215803.DB30_7046	2.177e-153	512.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,42MSV@68525|delta/epsilon subdivisions,2WJ6U@28221|Deltaproteobacteria,2YUNP@29|Myxococcales	28221|Deltaproteobacteria	M	Transglycosylase	-	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
CMS2_k127_5123966_4	1121396.KB893062_gene2761	4.256e-150	483.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42NHU@68525|delta/epsilon subdivisions,2WIZ1@28221|Deltaproteobacteria,2MIQ6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.99.32	ko:K16173	ko00362,ko01120,map00362,map01120	-	R05579	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS2_k127_5123966_0	335543.Sfum_3582	9.562e-195	613.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2MRCD@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS2_k127_5123966_6	335543.Sfum_3583	9.37e-135	434.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,2MQSA@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	mmgB	-	1.1.1.157,1.1.1.35,4.2.1.17	ko:K00074,ko:K15016	ko00360,ko00362,ko00650,ko00720,ko01100,ko01120,ko01200,map00360,map00362,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R01975,R01976,R03026,R05576,R06941	RC00029,RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2269	3HCDH,3HCDH_N
CMS2_k127_5123966_7	335543.Sfum_3584	1.505e-120	391.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,42QPM@68525|delta/epsilon subdivisions,2WMRG@28221|Deltaproteobacteria,2MQER@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	3HCDH_N,ECH_1
CMS2_k127_5123966_11	1280390.CBQR020000102_gene2605	1.016e-61	226.0	2E1HS@1|root,32WVU@2|Bacteria,1VRDQ@1239|Firmicutes,4HUUG@91061|Bacilli,270M7@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5123966_2	1121396.KB893079_gene859	1.456e-155	505.0	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42NMK@68525|delta/epsilon subdivisions,2WK6K@28221|Deltaproteobacteria,2MJD2@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_5123966_8	521674.Plim_2762	7.302e-114	400.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,2J53G@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,Response_reg
CMS2_k127_5123966_9	1379698.RBG1_1C00001G1345	3.9e-70	258.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2NQ3V@2323|unclassified Bacteria	2|Bacteria	KT	COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit	rsbU	-	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	GAF,GAF_2,HATPase_c_2,SSF,SpoIIE
CMS2_k127_5123966_10	1047013.AQSP01000088_gene1630	5.25e-69	246.0	COG0457@1|root,COG0457@2|Bacteria	1047013.AQSP01000088_gene1630|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5123966_13	1047013.AQSP01000123_gene1526	2.005e-36	150.0	COG4219@1|root,COG4219@2|Bacteria,2NR11@2323|unclassified Bacteria	2|Bacteria	KT	Peptidase M56	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	DUF4367,TonB_C
CMS2_k127_5123966_5	1047013.AQSP01000123_gene1527	6.898e-144	481.0	COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,2NR7I@2323|unclassified Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
CMS2_k127_5123966_14	28072.Nos7524_1685	1.228e-07	61.0	COG2304@1|root,COG3209@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,1GK47@1117|Cyanobacteria,1HT8F@1161|Nostocales	1117|Cyanobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
CMS2_k127_5123966_1	926692.AZYG01000093_gene1719	2.882e-179	575.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248K6@186801|Clostridia	186801|Clostridia	L	DNA polymerase	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,HNH,RVT_1,RVT_N
CMS2_k127_5123966_12	760192.Halhy_1128	9.506e-40	165.0	COG3209@1|root,COG3209@2|Bacteria,4NFUE@976|Bacteroidetes,1INSI@117747|Sphingobacteriia	976|Bacteroidetes	M	COG3209 Rhs family protein	rhsA	-	-	-	-	-	-	-	-	-	-	-	RHS,RHS_repeat
CMS2_k127_5136320_1	1047013.AQSP01000140_gene2470	1.873e-88	303.0	COG1228@1|root,COG1228@2|Bacteria,2NNTC@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
CMS2_k127_5136320_0	1452718.JBOY01000066_gene2403	1.524e-100	342.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
CMS2_k127_5136320_2	1047013.AQSP01000140_gene2472	1.763e-73	253.0	COG0849@1|root,COG0849@2|Bacteria,2NNU2@2323|unclassified Bacteria	2|Bacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
CMS2_k127_5140787_2	1042163.BRLA_c025640	0.0	1100.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5140787_0	573061.Clocel_2482	0.0	1553.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5140787_1	536232.CLM_0374	0.0	1374.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5143383_0	1144275.COCOR_05234	1.185e-105	370.0	COG0349@1|root,COG1201@1|root,COG0349@2|Bacteria,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,42R0A@68525|delta/epsilon subdivisions,2WMYR@28221|Deltaproteobacteria,2YUI1@29|Myxococcales	28221|Deltaproteobacteria	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DNA_pol_A_exo1,Helicase_C
CMS2_k127_5143383_6	1280001.BAOA01000232_gene4320	4.438e-14	81.0	arCOG09511@1|root,2Z9DH@2|Bacteria,1MXRV@1224|Proteobacteria,1SEJ5@1236|Gammaproteobacteria,1XZ1Y@135623|Vibrionales	135623|Vibrionales	S	FRG	-	-	-	-	-	-	-	-	-	-	-	-	FRG
CMS2_k127_5143383_4	1410661.JNKW01000001_gene889	8.01e-23	101.0	COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia	186801|Clostridia	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS2_k127_5143383_5	1033802.SSPSH_002227	4.591e-20	95.0	2978X@1|root,2ZUGN@2|Bacteria,1NM3Z@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5143383_2	886379.AEWI01000141_gene2224	1.739e-72	253.0	COG2253@1|root,COG2253@2|Bacteria,4NHEP@976|Bacteroidetes,2FPV7@200643|Bacteroidia	976|Bacteroidetes	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS2_k127_5143383_3	886379.AEWI01000141_gene2225	4.075e-44	168.0	COG5340@1|root,COG5340@2|Bacteria,4NM5Y@976|Bacteroidetes,2FNCI@200643|Bacteroidia	976|Bacteroidetes	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5143383_1	1047013.AQSP01000140_gene2488	1.128e-73	269.0	COG4254@1|root,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
CMS2_k127_5146265_4	665571.STHERM_c16920	4.351e-21	99.0	COG2250@1|root,COG2250@2|Bacteria,2J9AK@203691|Spirochaetes	203691|Spirochaetes	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_5146265_6	565033.GACE_2015	2.731e-06	53.0	COG1708@1|root,arCOG01195@2157|Archaea,2Y3Y7@28890|Euryarchaeota,2478P@183980|Archaeoglobi	183980|Archaeoglobi	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CMS2_k127_5146265_5	1122925.KB895390_gene1494	2.53e-20	93.0	COG0236@1|root,COG0236@2|Bacteria,1VMCB@1239|Firmicutes,4HR5M@91061|Bacilli,26ZWJ@186822|Paenibacillaceae	91061|Bacilli	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
CMS2_k127_5146265_3	189425.PGRAT_08085	4.565e-54	199.0	COG0500@1|root,COG2226@2|Bacteria,1UPKF@1239|Firmicutes,4I1XY@91061|Bacilli,270PC@186822|Paenibacillaceae	91061|Bacilli	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
CMS2_k127_5146265_0	358681.BBR47_39840	0.0	1500.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HUE5@91061|Bacilli,26VP1@186822|Paenibacillaceae	91061|Bacilli	Q	Pfam:HxxPF_rpt	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Condensation,Methyltransf_12,NAD_binding_4,PP-binding
CMS2_k127_5146265_1	711393.AYRX01000103_gene5911	7.163e-138	456.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_5146265_2	402777.KB235898_gene5550	1.83e-99	340.0	COG3319@1|root,COG3321@1|root,COG3319@2|Bacteria,COG3321@2|Bacteria,1GCBM@1117|Cyanobacteria,1HF3E@1150|Oscillatoriales	1117|Cyanobacteria	Q	Acyl transferase domain in polyketide synthase (PKS) enzymes.	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,PP-binding,Thioesterase
CMS2_k127_5153388_0	1122176.KB903542_gene386	5.964e-88	313.0	COG2312@1|root,COG2312@2|Bacteria,4NF9R@976|Bacteroidetes,1IU69@117747|Sphingobacteriia	976|Bacteroidetes	S	Erythromycin esterase	-	-	-	ko:K06880	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Erythro_esteras
CMS2_k127_5153388_1	1254432.SCE1572_51275	8.399e-69	252.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,42Q71@68525|delta/epsilon subdivisions,2WK8Q@28221|Deltaproteobacteria,2YTXS@29|Myxococcales	28221|Deltaproteobacteria	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C
CMS2_k127_5157579_4	717231.Flexsi_0532	4.683e-21	93.0	COG4799@1|root,COG4799@2|Bacteria,2GEP0@200930|Deferribacteres	200930|Deferribacteres	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
CMS2_k127_5157579_5	1122223.KB890687_gene2915	3.247e-20	102.0	COG1413@1|root,COG5330@1|root,COG1413@2|Bacteria,COG5330@2|Bacteria,1WMZN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Leucine rich repeat variant	-	-	-	-	-	-	-	-	-	-	-	-	LRV
CMS2_k127_5157579_6	384676.PSEEN2509	2.726e-05	49.0	2E4GH@1|root,32ZBP@2|Bacteria,1NDRK@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5157579_1	485917.Phep_0555	9.068e-86	299.0	COG4403@1|root,COG4403@2|Bacteria,4NJ29@976|Bacteroidetes,1IXQ4@117747|Sphingobacteriia	976|Bacteroidetes	V	Lanthionine synthetase C-like protein	-	-	-	ko:K20484	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001	-	-	-	LANC_like
CMS2_k127_5157579_0	1168034.FH5T_14340	4.274e-212	667.0	COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,2FMB0@200643|Bacteroidia	976|Bacteroidetes	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
CMS2_k127_5157579_2	1123371.ATXH01000050_gene2026	2.386e-64	234.0	COG5464@1|root,COG5464@2|Bacteria	2|Bacteria	S	double-stranded DNA endodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
CMS2_k127_5157579_3	933262.AXAM01000028_gene3343	6.376e-28	115.0	COG1373@1|root,COG1373@2|Bacteria,1MWDX@1224|Proteobacteria,4302U@68525|delta/epsilon subdivisions,2WVDX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_5163343_0	1042163.BRLA_c025640	2.542e-136	456.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5169632_3	866536.Belba_2776	6.432e-122	405.0	COG1538@1|root,COG1538@2|Bacteria,4NITS@976|Bacteroidetes,47U53@768503|Cytophagia	976|Bacteroidetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_5169632_2	694427.Palpr_2415	2.79e-136	447.0	COG0841@1|root,COG1538@1|root,COG0841@2|Bacteria,COG1538@2|Bacteria,4NDZG@976|Bacteroidetes,2FMG1@200643|Bacteroidia,22W2A@171551|Porphyromonadaceae	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS2_k127_5169632_13	1123276.KB893311_gene3124	2.314e-29	121.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47N6C@768503|Cytophagia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS2_k127_5169632_1	1122176.KB903535_gene2045	1.421e-142	464.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1IPVA@117747|Sphingobacteriia	976|Bacteroidetes	V	Protein export membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS2_k127_5169632_16	1123277.KB893176_gene3722	2.346e-16	82.0	COG0845@1|root,COG0845@2|Bacteria,4NF23@976|Bacteroidetes,47X99@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
CMS2_k127_5169632_11	1408473.JHXO01000005_gene1599	7.724e-43	164.0	COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,2FPPN@200643|Bacteroidia	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
CMS2_k127_5169632_9	866536.Belba_2773	1.02e-57	206.0	COG1309@1|root,COG1309@2|Bacteria,4NNNT@976|Bacteroidetes,47SG0@768503|Cytophagia	976|Bacteroidetes	K	Bacterial regulatory proteins, tetR family	qacR	-	-	-	-	-	-	-	-	-	-	-	TetR_C_5,TetR_N
CMS2_k127_5169632_8	573413.Spirs_0879	9.268e-80	282.0	COG0013@1|root,COG0013@2|Bacteria,2J75I@203691|Spirochaetes	203691|Spirochaetes	J	alanyl tRNA synthetase	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
CMS2_k127_5169632_4	1167006.UWK_00814	2.673e-112	375.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PZJ@68525|delta/epsilon subdivisions,2WMGB@28221|Deltaproteobacteria,2MNPX@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS2_k127_5169632_10	755731.Clo1100_3338	1.177e-48	189.0	COG1073@1|root,COG1073@2|Bacteria,1UXYN@1239|Firmicutes,24DU6@186801|Clostridia,36GR2@31979|Clostridiaceae	186801|Clostridia	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4
CMS2_k127_5169632_14	1121930.AQXG01000006_gene771	3e-29	127.0	COG0642@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_5169632_12	1144275.COCOR_00491	8.412e-43	181.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	MAM,Peptidase_M43,fn3
CMS2_k127_5169632_18	1313421.JHBV01000075_gene13	7.731e-08	66.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,Gram_pos_anchor
CMS2_k127_5169632_6	439235.Dalk_0237	9.507e-89	324.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_5169632_15	869213.JCM21142_41386	4.877e-25	115.0	COG2043@1|root,COG2043@2|Bacteria	2|Bacteria	C	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
CMS2_k127_5169632_0	1408473.JHXO01000002_gene3927	1.319e-290	917.0	COG3250@1|root,COG3250@2|Bacteria,4NE7H@976|Bacteroidetes,2FNT8@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.165	ko:K15855	ko00520,ko01100,map00520,map01100	-	R01966	RC00049	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
CMS2_k127_5169632_5	1047013.AQSP01000123_gene1525	1.055e-96	344.0	COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria,2NPK1@2323|unclassified Bacteria	2|Bacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
CMS2_k127_5169632_7	1499967.BAYZ01000090_gene4941	3.101e-87	317.0	2DDA6@1|root,2ZH98@2|Bacteria	2|Bacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT
CMS2_k127_5169632_17	526224.Bmur_1611	1.291e-09	64.0	COG5464@1|root,COG5464@2|Bacteria,2J7J6@203691|Spirochaetes	203691|Spirochaetes	S	PD-(D/E)XK nuclease family transposase	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_5174792_14	639282.DEFDS_2016	0.0001843	46.0	COG2253@1|root,COG2253@2|Bacteria	2|Bacteria	V	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS2_k127_5174792_0	1168289.AJKI01000007_gene136	1.827e-199	645.0	COG3590@1|root,COG3590@2|Bacteria,4NEYB@976|Bacteroidetes,2FP7Y@200643|Bacteroidia,3XKPS@558415|Marinilabiliaceae	976|Bacteroidetes	O	Peptidase family M13	pepO	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
CMS2_k127_5174792_10	1238182.C882_3888	3.072e-33	139.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,2TUER@28211|Alphaproteobacteria,2JQ68@204441|Rhodospirillales	204441|Rhodospirillales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
CMS2_k127_5174792_11	530564.Psta_1552	7.606e-31	131.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS2_k127_5174792_2	1304885.AUEY01000023_gene2672	1.334e-132	435.0	COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria,42NU5@68525|delta/epsilon subdivisions,2WJV4@28221|Deltaproteobacteria,2MJDU@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
CMS2_k127_5174792_13	862969.SCI_0837	6.775e-05	53.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,42D7X@671232|Streptococcus anginosus group	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059,ko:K07535	ko00061,ko00333,ko00362,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,ko01220,map00061,map00333,map00362,map00780,map01040,map01100,map01120,map01130,map01212,map01220	M00083,M00540,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05582,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117,RC00154	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
CMS2_k127_5174792_1	880073.Calab_3201	4.359e-160	514.0	COG4198@1|root,COG4198@2|Bacteria,2NNV0@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF1015)	gdh	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	DUF1015
CMS2_k127_5174792_6	1121904.ARBP01000009_gene4282	1.175e-69	249.0	COG0729@1|root,COG0729@2|Bacteria,4NMUN@976|Bacteroidetes,47MRN@768503|Cytophagia	976|Bacteroidetes	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
CMS2_k127_5174792_7	945713.IALB_1975	2.386e-63	236.0	COG1215@1|root,COG3222@1|root,COG1215@2|Bacteria,COG3222@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	3.4.14.13	ko:K09931,ko:K20742	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF2064,Glycos_transf_2
CMS2_k127_5174792_9	717231.Flexsi_2047	2.958e-57	207.0	COG0398@1|root,COG0398@2|Bacteria,2GFR0@200930|Deferribacteres	200930|Deferribacteres	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS2_k127_5174792_3	985255.APHJ01000017_gene2172	4.641e-116	389.0	COG1249@1|root,COG1249@2|Bacteria,4NEMS@976|Bacteroidetes,1HZI9@117743|Flavobacteriia	976|Bacteroidetes	C	Resistance to Hg(2 ) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0)	merA	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	HMA,Pyr_redox_2,Pyr_redox_dim
CMS2_k127_5174792_8	1232410.KI421421_gene3625	2.128e-58	213.0	COG0607@1|root,COG1633@1|root,COG0607@2|Bacteria,COG1633@2|Bacteria,1MZPW@1224|Proteobacteria,42NX5@68525|delta/epsilon subdivisions,2WMJ4@28221|Deltaproteobacteria,43TND@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,Rubrerythrin
CMS2_k127_5174792_4	338963.Pcar_2275	4.63e-114	379.0	COG1252@1|root,COG1252@2|Bacteria,1QUKT@1224|Proteobacteria,42MAW@68525|delta/epsilon subdivisions,2WJCB@28221|Deltaproteobacteria,43T8G@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
CMS2_k127_5174792_5	1047013.AQSP01000121_gene2692	3.635e-78	269.0	COG0110@1|root,COG0110@2|Bacteria,2NQ61@2323|unclassified Bacteria	2|Bacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.18	ko:K00633	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
CMS2_k127_5193292_0	357808.RoseRS_4529	5.845e-40	152.0	COG2445@1|root,COG2445@2|Bacteria,2G9SR@200795|Chloroflexi,377FU@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
CMS2_k127_5193292_1	161156.JQKW01000009_gene1641	5.759e-11	69.0	COG1669@1|root,COG1669@2|Bacteria,2GI57@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CMS2_k127_5210753_2	439235.Dalk_2729	2.196e-13	71.0	COG3809@1|root,COG3809@2|Bacteria,1PZB0@1224|Proteobacteria,433GD@68525|delta/epsilon subdivisions,2WXX5@28221|Deltaproteobacteria,2MP8T@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
CMS2_k127_5210753_0	483219.LILAB_18670	3.826e-107	361.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_2,Glyco_transf_4,Glyco_transf_9,Glycos_transf_1,Glycos_transf_2,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
CMS2_k127_5210753_1	483219.LILAB_18670	2.339e-27	120.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_2,Glyco_transf_4,Glyco_transf_9,Glycos_transf_1,Glycos_transf_2,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
CMS2_k127_5210753_3	485913.Krac_5920	0.0001193	46.0	COG0641@1|root,COG0641@2|Bacteria,2G74V@200795|Chloroflexi	200795|Chloroflexi	C	Iron-sulfur cluster-binding domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Radical_SAM,SPASM
CMS2_k127_5215337_0	1380391.JIAS01000013_gene3781	4.575e-296	950.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,2JUYT@204441|Rhodospirillales	204441|Rhodospirillales	S	Alpha-2-Macroglobulin	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2
CMS2_k127_5220155_0	177437.HRM2_34080	1.418e-121	430.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,1N26H@1224|Proteobacteria,43EV4@68525|delta/epsilon subdivisions,2WR4K@28221|Deltaproteobacteria,2MNP4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS2_k127_5220155_1	546271.Selsp_2083	1.545e-06	61.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4H4VD@909932|Negativicutes	909932|Negativicutes	E	ABC transporter substrate-binding protein family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS2_k127_5221930_1	880072.Desac_1891	2.77e-49	189.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,42MJR@68525|delta/epsilon subdivisions,2WPGB@28221|Deltaproteobacteria,2MRND@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	PFAM glycosyl transferase, family 9	-	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS2_k127_5221930_0	1353276.JADR01000005_gene2535	2.706e-51	194.0	28IIB@1|root,2Z8JE@2|Bacteria,4NT5A@976|Bacteroidetes,1I5Q3@117743|Flavobacteriia	976|Bacteroidetes	S	Glycosyltransferase family 10 (fucosyltransferase) C-term	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_10
CMS2_k127_5221930_2	756272.Plabr_3057	1.832e-40	160.0	COG1216@1|root,COG1216@2|Bacteria,2IZF5@203682|Planctomycetes	203682|Planctomycetes	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
CMS2_k127_5221930_3	3055.EDP02537	7.612e-05	53.0	KOG1022@1|root,KOG1022@2759|Eukaryota,37J4K@33090|Viridiplantae	33090|Viridiplantae	GMW	Glycosyltransferase family protein 64	-	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005794,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006029,GO:0006040,GO:0006044,GO:0006082,GO:0006790,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0008101,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0008589,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009966,GO:0009967,GO:0009987,GO:0010646,GO:0010647,GO:0012505,GO:0015012,GO:0015014,GO:0015020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019538,GO:0023051,GO:0023052,GO:0023056,GO:0030111,GO:0030166,GO:0030177,GO:0030201,GO:0030202,GO:0030203,GO:0030204,GO:0030206,GO:0030210,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045880,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050508,GO:0050509,GO:0050650,GO:0050654,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060828,GO:0065007,GO:0071704,GO:0090092,GO:0090097,GO:0090098,GO:0090100,GO:0090263,GO:1901071,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903510	-	-	-	-	-	-	-	-	-	-	Glyco_transf_64
CMS2_k127_5229990_2	575788.VS_1761	5.493e-20	93.0	COG0596@1|root,COG0596@2|Bacteria,1R4N4@1224|Proteobacteria,1SZC9@1236|Gammaproteobacteria,1Y2UW@135623|Vibrionales	135623|Vibrionales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5229990_1	1449126.JQKL01000037_gene2034	6.133e-60	212.0	COG1611@1|root,COG1611@2|Bacteria,1UKED@1239|Firmicutes,24DSN@186801|Clostridia	186801|Clostridia	L	Belongs to the LOG family	yvdD	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS2_k127_5229990_0	1047013.AQSP01000114_gene684	2.317e-225	715.0	COG1629@1|root,COG2304@1|root,COG1629@2|Bacteria,COG2304@2|Bacteria,2NQ3W@2323|unclassified Bacteria	2|Bacteria	P	von Willebrand factor type A domain	yfbK	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	CarbopepD_reg_2,DUF3520,Plug,VWA,vWF_A
CMS2_k127_5258584_12	1196028.ALEF01000050_gene3487	1.03e-11	69.0	COG0123@1|root,COG0123@2|Bacteria,1TQF7@1239|Firmicutes,4HBTF@91061|Bacilli,4C593@84406|Virgibacillus	91061|Bacilli	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	iYO844.BSU29710	Hist_deacetyl
CMS2_k127_5258584_11	330214.NIDE1089	4.815e-28	123.0	COG1040@1|root,COG1040@2|Bacteria,3J19P@40117|Nitrospirae	40117|Nitrospirae	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
CMS2_k127_5258584_9	329726.AM1_0146	1.279e-37	159.0	COG2334@1|root,COG2334@2|Bacteria,1G3HF@1117|Cyanobacteria	1117|Cyanobacteria	S	homoserine kinase type II (Protein kinase fold)	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS2_k127_5258584_13	1227739.Hsw_PA0101	2.345e-07	63.0	COG2320@1|root,COG2334@1|root,COG2320@2|Bacteria,COG2334@2|Bacteria,4NGVS@976|Bacteroidetes,47NTM@768503|Cytophagia	976|Bacteroidetes	T	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS2_k127_5258584_4	755731.Clo1100_0886	4.951e-122	404.0	COG0331@1|root,COG0331@2|Bacteria,1TRDU@1239|Firmicutes,24DDF@186801|Clostridia	186801|Clostridia	I	PFAM Acyl transferase	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
CMS2_k127_5258584_6	391613.RTM1035_07003	1.851e-51	191.0	COG1794@1|root,COG1794@2|Bacteria,1RC4J@1224|Proteobacteria,2U634@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Asp/Glu/Hydantoin racemase	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
CMS2_k127_5258584_8	1123035.ARLA01000022_gene668	7.003e-44	168.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
CMS2_k127_5258584_10	491205.JARQ01000003_gene2221	4.134e-37	156.0	COG1819@1|root,COG1819@2|Bacteria,4P226@976|Bacteroidetes	976|Bacteroidetes	CG	glycosyl	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5258584_0	649747.HMPREF0083_00279	0.0	3049.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16123,ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5258584_3	1007103.AFHW01000086_gene6555	5.033e-125	456.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	bacA1	-	-	ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5258584_7	289376.THEYE_A1734	1.073e-44	190.0	COG0476@1|root,COG0476@2|Bacteria	2|Bacteria	H	Involved in molybdopterin and thiamine biosynthesis, family 2	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
CMS2_k127_5258584_2	394503.Ccel_2386	5.612e-234	807.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_5258584_1	1121121.KB894288_gene2765	0.0	1744.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_5258584_5	755731.Clo1100_2633	2.359e-62	224.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_5267080_2	656519.Halsa_0781	3.217e-64	231.0	COG2407@1|root,COG2407@2|Bacteria,1TPEK@1239|Firmicutes,24BY2@186801|Clostridia	186801|Clostridia	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5267080_3	1316936.K678_09705	9.31e-36	154.0	2EQWR@1|root,33IGI@2|Bacteria,1NNN3@1224|Proteobacteria,2UJW6@28211|Alphaproteobacteria,2JVIF@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5267080_0	386415.NT01CX_1554	7.298e-139	457.0	COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,248V4@186801|Clostridia,36DV2@31979|Clostridiaceae	186801|Clostridia	M	membrane protein involved in D-alanine export	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
CMS2_k127_5267080_5	316055.RPE_4245	2.58e-16	90.0	295MH@1|root,2ZSYX@2|Bacteria,1PBGZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5267080_4	1047013.AQSP01000144_gene893	2.288e-23	115.0	COG1807@1|root,COG1807@2|Bacteria,2NRMD@2323|unclassified Bacteria	2|Bacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS2_k127_5267080_1	96561.Dole_2466	2.735e-84	301.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PTPS_related,YfhO
CMS2_k127_5269829_13	755731.Clo1100_0879	6.968e-108	368.0	COG1680@1|root,COG4615@1|root,COG1680@2|Bacteria,COG4615@2|Bacteria,1TRPT@1239|Firmicutes,2495H@186801|Clostridia,36GUT@31979|Clostridiaceae	186801|Clostridia	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,Beta-lactamase,DUF302
CMS2_k127_5269829_11	720554.Clocl_2664	1.487e-118	394.0	COG0331@1|root,COG0331@2|Bacteria,1TRDU@1239|Firmicutes,24DDF@186801|Clostridia,3WIDQ@541000|Ruminococcaceae	186801|Clostridia	I	PFAM Acyl transferase	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
CMS2_k127_5269829_19	63737.Npun_R3441	1.654e-24	105.0	COG0236@1|root,COG0236@2|Bacteria,1G854@1117|Cyanobacteria,1HT7T@1161|Nostocales	1117|Cyanobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
CMS2_k127_5269829_12	398512.JQKC01000009_gene568	1.672e-109	372.0	COG1020@1|root,COG1020@2|Bacteria,1V12Q@1239|Firmicutes,24ER3@186801|Clostridia,3WNBS@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,PP-binding,QueC,Radical_SAM
CMS2_k127_5269829_8	398512.JQKC01000015_gene4632	2.368e-172	548.0	COG0826@1|root,COG0826@2|Bacteria,1VT61@1239|Firmicutes,24AZY@186801|Clostridia,3WRXE@541000|Ruminococcaceae	186801|Clostridia	O	Peptidase family U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
CMS2_k127_5269829_15	398512.JQKC01000015_gene4633	2.891e-83	289.0	COG2120@1|root,COG2120@2|Bacteria,1UUR1@1239|Firmicutes,257J2@186801|Clostridia,3WR4X@541000|Ruminococcaceae	186801|Clostridia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS2_k127_5269829_7	398512.JQKC01000015_gene4634	1.129e-184	585.0	COG0826@1|root,COG0826@2|Bacteria,1VT69@1239|Firmicutes,25DBH@186801|Clostridia	186801|Clostridia	O	Peptidase family U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
CMS2_k127_5269829_4	398512.JQKC01000015_gene4635	4.047e-298	949.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WH7Q@541000|Ruminococcaceae	186801|Clostridia	Q	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_5269829_14	398512.JQKC01000015_gene4636	1.869e-107	364.0	COG0438@1|root,COG0438@2|Bacteria,1V1BU@1239|Firmicutes,24E05@186801|Clostridia,3WK5K@541000|Ruminococcaceae	186801|Clostridia	M	Glycosyl transferases group 1	-	-	2.4.1.291	ko:K17248	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1
CMS2_k127_5269829_1	398512.JQKC01000015_gene4637	0.0	1449.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WMYS@541000|Ruminococcaceae	186801|Clostridia	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_5269829_20	398512.JQKC01000015_gene4646	6.384e-17	83.0	2DCFC@1|root,2ZDWZ@2|Bacteria,1W2M2@1239|Firmicutes,257IA@186801|Clostridia,3WQSJ@541000|Ruminococcaceae	186801|Clostridia	S	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
CMS2_k127_5269829_6	573061.Clocel_2488	1.01e-217	737.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5269829_16	1499967.BAYZ01000088_gene5085	1.076e-49	196.0	2DN0H@1|root,32UQZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5269829_21	926556.Echvi_3014	1.157e-09	69.0	2DBJW@1|root,2Z9P2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5269829_17	880073.Calab_3408	5.194e-38	148.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Cytochrome_C554,DUF11,SLH
CMS2_k127_5269829_10	711393.AYRX01000103_gene5911	1.788e-137	454.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_5269829_2	573061.Clocel_2489	0.0	1184.0	COG0318@1|root,COG1020@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,PP-binding,Thioesterase
CMS2_k127_5269829_3	118005.AWNK01000004_gene1064	0.0	1074.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_5269829_22	1208583.COMX_04980	1.168e-08	66.0	COG0657@1|root,COG0657@2|Bacteria,1R74D@1224|Proteobacteria,2TY9G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Protein of unknown function (DUF1460)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1460
CMS2_k127_5269829_18	1192034.CAP_7227	5.878e-27	123.0	COG1434@1|root,COG1434@2|Bacteria,1NDJM@1224|Proteobacteria,42XJW@68525|delta/epsilon subdivisions,2WSJ3@28221|Deltaproteobacteria,2YVV6@29|Myxococcales	28221|Deltaproteobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
CMS2_k127_5269829_0	1042163.BRLA_c025650	0.0	1914.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15662	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5269829_5	394503.Ccel_2381	1.419e-243	791.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_31,PP-binding,ketoacyl-synt
CMS2_k127_5269829_9	755731.Clo1100_1301	6.583e-140	465.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,Thioesterase,ketoacyl-synt
CMS2_k127_5269992_7	41431.PCC8801_0162	5.631e-15	78.0	COG0515@1|root,COG0515@2|Bacteria	41431.PCC8801_0162|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5269992_6	1501230.ET33_13240	2.189e-91	307.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.7.1.83	ko:K16328	ko00240,map00240	-	R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
CMS2_k127_5269992_0	573061.Clocel_3940	2.393e-313	1012.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36G1U@31979|Clostridiaceae	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding
CMS2_k127_5269992_2	745411.B3C1_10727	1.457e-198	638.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1J8W5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	oligopeptide transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
CMS2_k127_5269992_4	1267534.KB906760_gene1406	1.323e-107	365.0	COG0591@1|root,COG0591@2|Bacteria,3Y34J@57723|Acidobacteria,2JIBW@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307,ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21,2.A.21.2	-	-	SSF
CMS2_k127_5269992_5	439235.Dalk_0237	1.051e-100	367.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_5269992_3	717231.Flexsi_0804	1.329e-155	499.0	COG1088@1|root,COG1088@2|Bacteria,2GFAW@200930|Deferribacteres	200930|Deferribacteres	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
CMS2_k127_5269992_1	1047013.AQSP01000105_gene1461	6.663e-203	660.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2NNS9@2323|unclassified Bacteria	2|Bacteria	EU	peptidase S9 prolyl oligopeptidase active site	dap2	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
CMS2_k127_5272746_0	1296416.JACB01000029_gene4099	5.151e-66	249.0	COG2898@1|root,COG3321@1|root,COG2898@2|Bacteria,COG3321@2|Bacteria,4PKD5@976|Bacteroidetes,1HYG4@117743|Flavobacteriia,2YHN1@290174|Aquimarina	976|Bacteroidetes	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Beta_elim_lyase,DUF2156,ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_530742_0	65093.PCC7418_0724	6.607e-113	378.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1G1Q1@1117|Cyanobacteria	1117|Cyanobacteria	EU	PFAM Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS2_k127_5314669_10	765913.ThidrDRAFT_0150	2.496e-84	297.0	COG3591@1|root,COG5640@1|root,COG3591@2|Bacteria,COG5640@2|Bacteria,1RFR4@1224|Proteobacteria,1SZFK@1236|Gammaproteobacteria,1X18M@135613|Chromatiales	135613|Chromatiales	EO	Trypsin-like serine protease	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin,Trypsin_2
CMS2_k127_5314669_0	709991.Odosp_3645	4.161e-189	600.0	COG0006@1|root,COG0006@2|Bacteria,4NG40@976|Bacteroidetes,2FMSQ@200643|Bacteroidia,22WVB@171551|Porphyromonadaceae	976|Bacteroidetes	E	Aminopeptidase P, N-terminal domain	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
CMS2_k127_5314669_8	391603.FBALC1_00637	2.246e-92	310.0	28KF8@1|root,2ZA1G@2|Bacteria,4NK7X@976|Bacteroidetes,1I0C7@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5314669_19	1123373.ATXI01000024_gene116	8.512e-39	149.0	COG0778@1|root,COG0778@2|Bacteria,2GHHZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS2_k127_5314669_7	1499967.BAYZ01000165_gene6643	2.839e-99	339.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
CMS2_k127_5314669_22	1526927.Plano_0784	4.105e-07	60.0	COG4106@1|root,COG4106@2|Bacteria,1TRDY@1239|Firmicutes,4HEFZ@91061|Bacilli,26DC2@186818|Planococcaceae	91061|Bacilli	S	Protein of unknown function (DUF938)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_25,Methyltransf_31
CMS2_k127_5314669_4	456320.Mvol_0234	4.746e-130	425.0	COG0037@1|root,arCOG15275@2157|Archaea,2Y0EE@28890|Euryarchaeota,23RGF@183939|Methanococci	183939|Methanococci	D	NAD synthase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5314669_9	1196322.A370_05137	8.756e-89	299.0	COG0107@1|root,COG0107@2|Bacteria,1TY4A@1239|Firmicutes,24FPW@186801|Clostridia,36RT0@31979|Clostridiaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	-	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CMS2_k127_5314669_13	1355374.JARU01000006_gene1776	2.021e-71	246.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,42QX8@68525|delta/epsilon subdivisions,2YP1G@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH2	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
CMS2_k127_5314669_11	1454004.AW11_02502	2.106e-77	274.0	COG0438@1|root,COG0438@2|Bacteria,1MYJ6@1224|Proteobacteria,2VRG3@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
CMS2_k127_5314669_1	204536.SULAZ_0349	1.076e-176	574.0	COG0367@1|root,COG0367@2|Bacteria,2G4Q5@200783|Aquificae	200783|Aquificae	F	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS2_k127_5314669_15	1250278.JQNQ01000001_gene2517	4.547e-48	188.0	COG0438@1|root,COG0438@2|Bacteria,4NFEV@976|Bacteroidetes,1HYUE@117743|Flavobacteriia	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	ko:K16703	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glycos_transf_1
CMS2_k127_5314669_16	1227487.C474_08117	1.348e-47	183.0	arCOG01387@1|root,arCOG01387@2157|Archaea	2157|Archaea	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_5314669_21	317025.Tcr_1514	7.849e-11	74.0	COG3562@1|root,COG3562@2|Bacteria	2|Bacteria	M	capsule polysaccharide	kpsS	-	-	ko:K07265	-	-	-	-	ko00000	-	-	-	Capsule_synth
CMS2_k127_5314669_17	113355.CM001775_gene2130	9.704e-47	178.0	COG3119@1|root,COG3119@2|Bacteria,1G15J@1117|Cyanobacteria	1117|Cyanobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_5314669_6	43989.cce_4549	3.459e-105	354.0	COG1134@1|root,COG1134@2|Bacteria,1GD6M@1117|Cyanobacteria,3KFU8@43988|Cyanothece	1117|Cyanobacteria	GM	Wzt C-terminal domain	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
CMS2_k127_5314669_12	304371.MCP_1013	6.78e-76	263.0	COG1682@1|root,arCOG04339@2157|Archaea	2157|Archaea	GM	PFAM ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
CMS2_k127_5314669_5	1047013.AQSP01000124_gene2684	1.584e-110	373.0	COG1109@1|root,COG1109@2|Bacteria,2NNTH@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	femD	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS2_k127_5314669_3	367737.Abu_0692	4.24e-134	437.0	COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,42MSY@68525|delta/epsilon subdivisions,2YT5V@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.14,5.1.3.23	ko:K01791,ko:K13019	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R09600	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
CMS2_k127_5314669_2	761193.Runsl_3524	3.928e-134	441.0	COG0531@1|root,COG0531@2|Bacteria,4NH7J@976|Bacteroidetes,47KCV@768503|Cytophagia	976|Bacteroidetes	E	PFAM amino acid permease-associated region	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
CMS2_k127_5314669_14	1499967.BAYZ01000027_gene1768	3.453e-67	236.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,2NR8B@2323|unclassified Bacteria	2|Bacteria	T	NACHT domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,NACHT,NPCBM,PEGA,Pkinase
CMS2_k127_5316465_7	420324.KI911965_gene1195	2.738e-66	232.0	COG0546@1|root,COG0546@2|Bacteria,1REXF@1224|Proteobacteria,2VG24@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	HAD-hyrolase-like	MA20_36165	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS2_k127_5316465_9	756067.MicvaDRAFT_3675	2.078e-48	190.0	COG3372@1|root,COG3372@2|Bacteria,1G0P2@1117|Cyanobacteria,1H7P6@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF790)	-	-	-	ko:K09744	-	-	-	-	ko00000	-	-	-	DUF790
CMS2_k127_5316465_3	1123508.JH636442_gene4262	9.369e-97	334.0	COG1061@1|root,COG1061@2|Bacteria,2IYDQ@203682|Planctomycetes	203682|Planctomycetes	L	ERCC3/RAD25/XPB C-terminal helicase	-	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,ResIII
CMS2_k127_5316465_5	1443665.JACA01000047_gene5305	7.779e-83	283.0	2FDZN@1|root,345ZW@2|Bacteria,4PGWG@976|Bacteroidetes,1IHMY@117743|Flavobacteriia,2YI54@290174|Aquimarina	976|Bacteroidetes	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
CMS2_k127_5316465_11	1304885.AUEY01000010_gene1663	1.119e-28	122.0	COG1193@1|root,COG1193@2|Bacteria,1QWNQ@1224|Proteobacteria,43BTQ@68525|delta/epsilon subdivisions,2X74M@28221|Deltaproteobacteria,2MPJZ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Smr domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
CMS2_k127_5316465_8	1047013.AQSP01000138_gene1055	3.137e-53	212.0	2DTK7@1|root,33KQU@2|Bacteria,2NRAS@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5316465_4	523850.TON_0312	1.457e-94	327.0	COG0534@1|root,arCOG01731@2157|Archaea,2XU54@28890|Euryarchaeota,242UC@183968|Thermococci	183968|Thermococci	V	Polysaccharide biosynthesis C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS2_k127_5316465_1	1047013.AQSP01000113_gene745	5.608e-116	377.0	COG1131@1|root,COG1131@2|Bacteria,2NNKB@2323|unclassified Bacteria	2|Bacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	gldA	-	3.6.3.7	ko:K01990,ko:K09697	ko02010,ko02020,map02010,map02020	M00253,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.115	-	-	ABC_tran
CMS2_k127_5316465_2	1047013.AQSP01000113_gene744	1.058e-109	359.0	COG1277@1|root,COG1277@2|Bacteria,2NPGK@2323|unclassified Bacteria	2|Bacteria	S	ABC-2 family transporter protein	gldF	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
CMS2_k127_5316465_0	1047013.AQSP01000113_gene743	3.781e-282	885.0	COG3225@1|root,COG3225@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC_transp_aux
CMS2_k127_5316465_6	1047013.AQSP01000113_gene742	3.318e-72	256.0	28V7D@1|root,2ZHAI@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
CMS2_k127_5316465_10	457570.Nther_2924	1.094e-28	133.0	COG0739@1|root,COG0739@2|Bacteria,1V3ZU@1239|Firmicutes,24JM4@186801|Clostridia	186801|Clostridia	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CMS2_k127_5316465_15	1499967.BAYZ01000068_gene1958	1.115e-12	81.0	COG4796@1|root,COG4796@2|Bacteria,2NPEQ@2323|unclassified Bacteria	2|Bacteria	U	Secretin and TonB N terminus short domain	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
CMS2_k127_5316465_13	1047013.AQSP01000078_gene2048	2.364e-25	122.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,TonB_C
CMS2_k127_5316465_12	1047013.AQSP01000078_gene2050	1.631e-28	122.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088,ko:K07263	-	-	-	-	ko00000,ko01000,ko01002,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_5316465_16	1454007.JAUG01000013_gene2403	6.925e-10	69.0	2EBYR@1|root,335Y1@2|Bacteria,4P40B@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5316465_14	760192.Halhy_0899	3.558e-25	108.0	COG5464@1|root,COG5464@2|Bacteria,4NGSI@976|Bacteroidetes	976|Bacteroidetes	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_5325830_12	123214.PERMA_1173	5.847e-10	61.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
CMS2_k127_5325830_5	1047013.AQSP01000138_gene1062	8.444e-75	265.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23,Methyltransf_25
CMS2_k127_5325830_0	246194.CHY_0410	3.447e-239	753.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,42F8U@68295|Thermoanaerobacterales	186801|Clostridia	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
CMS2_k127_5325830_7	1485545.JQLW01000009_gene190	4.046e-59	214.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria	1224|Proteobacteria	O	Peptidyl-prolyl cis-trans	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C,FKBP_N
CMS2_k127_5325830_11	1469948.JPNB01000002_gene2532	9.23e-11	72.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36DH1@31979|Clostridiaceae	186801|Clostridia	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
CMS2_k127_5325830_9	656519.Halsa_1055	6.194e-13	80.0	COG2204@1|root,COG2204@2|Bacteria,1V6R9@1239|Firmicutes,24IX3@186801|Clostridia,3WBDM@53433|Halanaerobiales	186801|Clostridia	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,TPR_2,TPR_8
CMS2_k127_5325830_2	247490.KSU1_C0449	2.259e-110	374.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,DUF4347,Peptidase_S8
CMS2_k127_5325830_4	1167006.UWK_02787	1.641e-76	275.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria,2MJZM@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,PocR,Response_reg,SBP_bac_3,sCache_2
CMS2_k127_5325830_8	243090.RB12541	2.67e-24	116.0	COG0526@1|root,COG0526@2|Bacteria,2J35Z@203682|Planctomycetes	203682|Planctomycetes	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
CMS2_k127_5325830_3	1079460.ATTQ01000067_gene6624	1.746e-107	362.0	COG5634@1|root,COG5634@2|Bacteria,1Q71I@1224|Proteobacteria,2VD5H@28211|Alphaproteobacteria,4BAGM@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Endoribonuclease XendoU	-	-	-	-	-	-	-	-	-	-	-	-	XendoU
CMS2_k127_5325830_13	457424.BFAG_03425	5.057e-05	48.0	COG5464@1|root,COG5464@2|Bacteria,4NGSI@976|Bacteroidetes,2FN70@200643|Bacteroidia,4AMN3@815|Bacteroidaceae	976|Bacteroidetes	S	PD-(D/E)XK nuclease family transposase	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_5325830_1	272559.BF9343_3718	5.817e-128	426.0	COG0641@1|root,COG0641@2|Bacteria,4NGXS@976|Bacteroidetes,2FN8M@200643|Bacteroidia,4AMP9@815|Bacteroidaceae	976|Bacteroidetes	C	4Fe-4S single cluster domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
CMS2_k127_5325830_6	873513.HMPREF6485_2284	6.391e-60	223.0	COG0535@1|root,COG0535@2|Bacteria,4NWZI@976|Bacteroidetes,2FSBU@200643|Bacteroidia	976|Bacteroidetes	S	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5325830_10	111781.Lepto7376_0368	1.82e-12	72.0	COG1345@1|root,COG1345@2|Bacteria	2|Bacteria	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	GO:0001539,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
CMS2_k127_5326240_0	1296415.JACC01000106_gene3756	1.166e-206	648.0	COG2801@1|root,COG2801@2|Bacteria,4NWHG@976|Bacteroidetes,1IMJP@117743|Flavobacteriia	976|Bacteroidetes	L	leucine-zipper of insertion element IS481	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve_3
CMS2_k127_5326240_1	1296416.JACB01000016_gene4528	9.195e-58	202.0	COG4805@1|root,COG4805@2|Bacteria,4NJUJ@976|Bacteroidetes,1I8FC@117743|Flavobacteriia,2YH5S@290174|Aquimarina	976|Bacteroidetes	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
CMS2_k127_5326242_2	1449350.OCH239_17360	4.676e-82	282.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
CMS2_k127_5326242_5	313612.L8106_08596	4.971e-49	185.0	29CTD@1|root,2ZZRI@2|Bacteria,1G61C@1117|Cyanobacteria,1HEIZ@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5326242_4	204536.SULAZ_0150	3.644e-61	214.0	COG0054@1|root,COG0054@2|Bacteria,2G3YV@200783|Aquificae	200783|Aquificae	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
CMS2_k127_5326242_6	1461580.CCAS010000002_gene329	1.443e-17	87.0	COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,4HKMU@91061|Bacilli,1ZH3P@1386|Bacillus	91061|Bacilli	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
CMS2_k127_5326242_0	868595.Desca_0169	1.422e-159	517.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,260CD@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
CMS2_k127_5326242_3	526222.Desal_2526	3.715e-78	276.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,2M7ZM@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
CMS2_k127_5326242_1	439235.Dalk_0937	4.258e-83	289.0	COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,42N6K@68525|delta/epsilon subdivisions,2WKFH@28221|Deltaproteobacteria,2MI37@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
CMS2_k127_5326242_7	1232453.BAIF02000074_gene4740	5.044e-09	58.0	COG3267@1|root,COG3267@2|Bacteria,1TRGM@1239|Firmicutes,24EPV@186801|Clostridia	186801|Clostridia	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
CMS2_k127_5329975_18	1293054.HSACCH_02457	2.588e-10	70.0	COG3903@1|root,COG3903@2|Bacteria,1UH90@1239|Firmicutes,24TRS@186801|Clostridia	186801|Clostridia	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5329975_10	1144275.COCOR_03659	5.727e-65	239.0	COG4403@1|root,COG4403@2|Bacteria,1R8AJ@1224|Proteobacteria,43EZ6@68525|delta/epsilon subdivisions,2WYJK@28221|Deltaproteobacteria,2YZ2R@29|Myxococcales	1224|Proteobacteria	V	Lanthionine synthetase C-like protein	-	-	-	ko:K20484	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001	-	-	-	LANC_like
CMS2_k127_5329975_19	526224.Bmur_1611	1.949e-09	69.0	COG5464@1|root,COG5464@2|Bacteria,2J7J6@203691|Spirochaetes	203691|Spirochaetes	S	PD-(D/E)XK nuclease family transposase	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_5329975_9	1345695.CLSA_c37640	6.723e-104	355.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36QT1@31979|Clostridiaceae	186801|Clostridia	Q	Phosphopantetheine attachment site	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_31,NAD_binding_4,PP-binding
CMS2_k127_5329975_7	711393.AYRX01000103_gene5911	2.195e-139	461.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_5329975_2	1408422.JHYF01000017_gene1871	1.1e-322	1032.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5329975_6	398512.JQKC01000015_gene4634	3.211e-147	477.0	COG0826@1|root,COG0826@2|Bacteria,1VT69@1239|Firmicutes,25DBH@186801|Clostridia	186801|Clostridia	O	Peptidase family U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
CMS2_k127_5329975_3	509191.AEDB02000067_gene915	1.068e-290	939.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NAD_binding_4,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_5329975_12	596152.DesU5LDRAFT_1426	3.919e-61	228.0	COG1244@1|root,COG1244@2|Bacteria,1QMRV@1224|Proteobacteria,43742@68525|delta/epsilon subdivisions,2X1YG@28221|Deltaproteobacteria,2MFVA@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_5329975_0	536232.CLM_0373	0.0	2314.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5329975_5	509191.AEDB02000067_gene916	9.893e-192	613.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_5329975_4	926692.AZYG01000011_gene1124	5.652e-234	782.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding
CMS2_k127_5329975_14	879212.DespoDRAFT_02821	1.744e-44	165.0	COG5573@1|root,COG5573@2|Bacteria,1N9U9@1224|Proteobacteria,42X8Z@68525|delta/epsilon subdivisions,2WT8G@28221|Deltaproteobacteria,2MMB8@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_5329975_17	879212.DespoDRAFT_02822	1.958e-22	98.0	299SZ@1|root,2ZWV7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5329975_21	196367.JNFG01000200_gene3071	0.0006291	42.0	COG2026@1|root,COG2026@2|Bacteria,1NGC6@1224|Proteobacteria	1224|Proteobacteria	DJ	cytotoxic translational repressor of toxin-antitoxin	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
CMS2_k127_5329975_20	398767.Glov_2915	6.767e-05	49.0	COG0028@1|root,COG1361@1|root,COG3468@1|root,COG5492@1|root,COG0028@2|Bacteria,COG1361@2|Bacteria,COG3468@2|Bacteria,COG5492@2|Bacteria,1QVSF@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF11,DUF1566,Laminin_G_3,OmpA,OmpA_membrane,TIG
CMS2_k127_5329975_15	118173.KB235914_gene2326	1.004e-30	122.0	COG1724@1|root,COG1724@2|Bacteria,1G890@1117|Cyanobacteria,1HC6J@1150|Oscillatoriales	1117|Cyanobacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
CMS2_k127_5329975_16	1089553.Tph_c01000	1.546e-30	121.0	COG1598@1|root,COG1598@2|Bacteria,1TUVG@1239|Firmicutes,25NCE@186801|Clostridia,42IWB@68295|Thermoanaerobacterales	186801|Clostridia	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5329975_8	1047013.AQSP01000123_gene1522	4.143e-109	380.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_5329975_11	1293054.HSACCH_02509	2.012e-63	232.0	COG0436@1|root,COG0436@2|Bacteria,1TQPD@1239|Firmicutes,24DQG@186801|Clostridia	186801|Clostridia	E	PFAM aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS2_k127_5329975_13	402880.MmarC5_0580	5.186e-45	176.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,23QEG@183939|Methanococci	183939|Methanococci	S	SMART Elongator protein 3 MiaB NifB	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
CMS2_k127_5329975_1	509191.AEDB02000085_gene2708	0.0	1302.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_5340221_2	344747.PM8797T_15596	6.026e-14	75.0	2BZBR@1|root,32YH6@2|Bacteria,2J41E@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5340221_0	756499.Desde_0761	1.058e-92	321.0	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia,263EX@186807|Peptococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_5347673_2	221288.JH992901_gene4010	1.488e-220	741.0	COG2986@1|root,COG2986@2|Bacteria,1G3FJ@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Phenylalanine and histidine ammonia-lyase	hutH	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009072,GO:0009698,GO:0009699,GO:0009800,GO:0009803,GO:0009987,GO:0016043,GO:0016053,GO:0016829,GO:0016840,GO:0016841,GO:0019438,GO:0019748,GO:0019752,GO:0022607,GO:0032787,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044550,GO:0045548,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	4.3.1.24,4.3.1.3	ko:K01745,ko:K10775	ko00340,ko00360,ko00940,ko01100,ko01110,map00340,map00360,map00940,map01100,map01110	M00039,M00045,M00137,M00350	R00697,R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
CMS2_k127_5347673_5	240292.Ava_3987	2.038e-213	720.0	COG0318@1|root,COG0318@2|Bacteria,1G2H0@1117|Cyanobacteria,1HIDR@1161|Nostocales	1117|Cyanobacteria	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
CMS2_k127_5347673_8	697282.Mettu_3702	8.216e-108	395.0	COG0318@1|root,COG3321@1|root,COG0318@2|Bacteria,COG3321@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NAD_binding_4,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
CMS2_k127_5347673_0	240292.Ava_3986	0.0	1697.0	COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1HIST@1161|Nostocales	1117|Cyanobacteria	Q	acyl transferase domain	-	-	-	ko:K16128	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2,AMP-binding,Acyl_transf_1,Aminotran_1_2,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_5347673_23	348824.LPU83_0663	9.251e-60	223.0	COG1409@1|root,COG1409@2|Bacteria,1R6R1@1224|Proteobacteria,2U1NR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_5347673_21	386456.JQKN01000002_gene2815	2.106e-62	233.0	COG1032@1|root,arCOG01356@2157|Archaea,2XU04@28890|Euryarchaeota,23PFJ@183925|Methanobacteria	183925|Methanobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_5347673_25	643562.Daes_0412	1.448e-55	213.0	COG1032@1|root,COG1032@2|Bacteria,1Q51D@1224|Proteobacteria,430IA@68525|delta/epsilon subdivisions,2WW4Y@28221|Deltaproteobacteria,2MF0C@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_5347673_14	56780.SYN_02920	1.437e-88	296.0	COG0655@1|root,COG0655@2|Bacteria,1RAK6@1224|Proteobacteria,42QS5@68525|delta/epsilon subdivisions,2WN2M@28221|Deltaproteobacteria,2MQXT@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS2_k127_5347673_6	1304888.ATWF01000001_gene2134	8.897e-133	445.0	COG4615@1|root,COG4615@2|Bacteria	2|Bacteria	V	microcin transport	-	-	-	ko:K06160	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.113.2	-	-	ABC_membrane,ABC_tran
CMS2_k127_5347673_24	1249627.D779_0239	1.929e-56	208.0	COG0330@1|root,COG0330@2|Bacteria,1RDFI@1224|Proteobacteria,1S655@1236|Gammaproteobacteria,1X0UN@135613|Chromatiales	135613|Chromatiales	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS2_k127_5347673_26	760154.Sulba_0744	1.341e-41	159.0	COG3597@1|root,COG3597@2|Bacteria,1MZA4@1224|Proteobacteria,43BFR@68525|delta/epsilon subdivisions,2YT87@29547|Epsilonproteobacteria	1224|Proteobacteria	S	protein associated with GTPases	-	-	-	-	-	-	-	-	-	-	-	-	DUF697
CMS2_k127_5347673_27	517418.Ctha_1971	3.69e-38	159.0	COG1073@1|root,COG1506@1|root,COG1073@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	LIP,Peptidase_S9
CMS2_k127_5347673_18	1116472.MGMO_72c00090	1.226e-79	294.0	COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,1RQ2K@1236|Gammaproteobacteria,1XFH2@135618|Methylococcales	135618|Methylococcales	P	TonB dependent receptor	-	-	-	ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14.2	-	-	Plug,TonB_dep_Rec
CMS2_k127_5347673_20	517417.Cpar_0764	1.463e-64	240.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,SH3_3,Transglycosylas
CMS2_k127_5347673_22	697282.Mettu_3753	8.45e-60	219.0	2DC1U@1|root,2ZCHV@2|Bacteria,1RAWF@1224|Proteobacteria,1SC4Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5347673_10	1173021.ALWA01000018_gene1008	2.219e-101	342.0	COG1118@1|root,COG1118@2|Bacteria,1G1GG@1117|Cyanobacteria	1117|Cyanobacteria	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE,TOBE_2,TOBE_3
CMS2_k127_5347673_16	886293.Sinac_0629	2.145e-85	291.0	COG4208@1|root,COG4208@2|Bacteria,2IXHP@203682|Planctomycetes	203682|Planctomycetes	P	TIGRFAM sulfate ABC transporter	-	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
CMS2_k127_5347673_15	886293.Sinac_0630	4.801e-88	300.0	COG0555@1|root,COG0555@2|Bacteria,2IYF4@203682|Planctomycetes	203682|Planctomycetes	P	TIGRFAM sulfate ABC transporter	-	-	-	ko:K02046	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
CMS2_k127_5347673_7	498761.HM1_1170	2.487e-125	411.0	COG1613@1|root,COG1613@2|Bacteria,1TS25@1239|Firmicutes,24B9S@186801|Clostridia	186801|Clostridia	P	Extracellular solute-binding protein	sbp	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
CMS2_k127_5347673_17	1499967.BAYZ01000095_gene4262	3.805e-84	287.0	COG1102@1|root,COG1102@2|Bacteria,2NRB0@2323|unclassified Bacteria	2|Bacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	BON,Cytidylate_kin2
CMS2_k127_5347673_19	1047013.AQSP01000135_gene1618	3.531e-67	235.0	COG0569@1|root,COG0569@2|Bacteria,2NPKV@2323|unclassified Bacteria	2|Bacteria	P	TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS2_k127_5347673_9	1047013.AQSP01000135_gene1617	1.673e-107	362.0	COG0168@1|root,COG0168@2|Bacteria,2NNW1@2323|unclassified Bacteria	2|Bacteria	P	Cation transport protein	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS2_k127_5347673_28	1382359.JIAL01000001_gene451	1.587e-35	141.0	COG0681@1|root,COG0681@2|Bacteria,3Y49Z@57723|Acidobacteria,2JJ4I@204432|Acidobacteriia	204432|Acidobacteriia	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
CMS2_k127_5347673_34	1047013.AQSP01000031_gene2002	0.0002536	51.0	COG2820@1|root,COG2820@2|Bacteria	2|Bacteria	F	uridine phosphorylase activity	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
CMS2_k127_5347673_13	484019.THA_1150	1.508e-89	305.0	COG1052@1|root,COG1052@2|Bacteria,2GC25@200918|Thermotogae	200918|Thermotogae	C	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS2_k127_5347673_12	640081.Dsui_2885	4.823e-95	340.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG5002@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg
CMS2_k127_5347673_11	1499967.BAYZ01000095_gene4075	1.937e-95	318.0	COG2220@1|root,COG2220@2|Bacteria,2NQD1@2323|unclassified Bacteria	2|Bacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CMS2_k127_5347673_4	1047013.AQSP01000133_gene2156	1.311e-215	685.0	COG0445@1|root,COG0445@2|Bacteria,2NNXQ@2323|unclassified Bacteria	2|Bacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
CMS2_k127_5347673_31	761193.Runsl_3337	7.263e-13	81.0	299RR@1|root,2ZWTZ@2|Bacteria,4P7V2@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5347673_1	1123277.KB893172_gene571	2.584e-240	767.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47JJN@768503|Cytophagia	976|Bacteroidetes	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_5347673_3	1499967.BAYZ01000095_gene4203	2.745e-219	730.0	COG0642@1|root,COG3292@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,2NQMI@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HATPase_c,HisKA,Hpt,PAS_3,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_5347673_29	1131269.AQVV01000004_gene570	2.569e-19	98.0	COG2849@1|root,COG2849@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2
CMS2_k127_5350657_0	266779.Meso_3941	2.014e-06	51.0	2DF04@1|root,2ZPYI@2|Bacteria,1P8I4@1224|Proteobacteria,2UXC6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5350657_1	1151292.QEW_2324	0.0003254	48.0	COG4980@1|root,COG4980@2|Bacteria,1VK4M@1239|Firmicutes,24VID@186801|Clostridia	186801|Clostridia	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
CMS2_k127_5366563_1	711393.AYRX01000103_gene5911	9.352e-96	328.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_5366563_0	1117108.PAALTS15_22598	0.0	1342.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5366563_2	509191.AEDB02000067_gene919	2.389e-31	140.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_5368301_0	1245471.PCA10_01210	7.714e-146	481.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,1YFDU@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	Sulfatase	atsA	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS2_k127_5368301_1	694430.Natoc_3927	1.706e-18	97.0	arCOG08925@1|root,arCOG08925@2157|Archaea,2XT8D@28890|Euryarchaeota,23TVZ@183963|Halobacteria	183963|Halobacteria	S	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
CMS2_k127_5368552_9	386456.JQKN01000001_gene1910	1.875e-79	274.0	COG0491@1|root,arCOG00504@2157|Archaea	2157|Archaea	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_5368552_2	1121422.AUMW01000003_gene869	5.043e-141	457.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,260KZ@186807|Peptococcaceae	186801|Clostridia	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	bcd2	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,ETF_alpha,Rubredoxin
CMS2_k127_5368552_23	935948.KE386494_gene348	2.371e-23	107.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,24MRS@186801|Clostridia,42GTV@68295|Thermoanaerobacterales	186801|Clostridia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
CMS2_k127_5368552_20	1480694.DC28_01225	2.751e-29	118.0	COG0211@1|root,COG0211@2|Bacteria,2J967@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
CMS2_k127_5368552_6	1123376.AUIU01000016_gene303	4.997e-97	329.0	COG0536@1|root,COG0536@2|Bacteria,3J0E3@40117|Nitrospirae	40117|Nitrospirae	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
CMS2_k127_5368552_19	1121289.JHVL01000002_gene2401	1.133e-29	128.0	COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,24JFM@186801|Clostridia,36I7Z@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
CMS2_k127_5368552_24	401053.AciPR4_4106	1.978e-21	98.0	COG0799@1|root,COG0799@2|Bacteria,3Y5SD@57723|Acidobacteria,2JJ9Z@204432|Acidobacteriia	204432|Acidobacteriia	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
CMS2_k127_5368552_16	768670.Calni_1249	2.753e-58	214.0	COG2204@1|root,COG2204@2|Bacteria,2GF35@200930|Deferribacteres	200930|Deferribacteres	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_5368552_7	1353529.M899_0745	1.473e-91	314.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria	1224|Proteobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS2_k127_5368552_4	1353529.M899_0744	1.089e-138	452.0	COG0301@1|root,COG0301@2|Bacteria,1MWD3@1224|Proteobacteria,42SKY@68525|delta/epsilon subdivisions	1224|Proteobacteria	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307	THUMP,ThiI
CMS2_k127_5368552_21	338966.Ppro_2479	1.067e-28	134.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42MVS@68525|delta/epsilon subdivisions,2WJKA@28221|Deltaproteobacteria,43TEP@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_5368552_0	1047013.AQSP01000070_gene34	1.126e-275	891.0	COG3292@1|root,COG3920@1|root,COG3292@2|Bacteria,COG3920@2|Bacteria,2NNZT@2323|unclassified Bacteria	2|Bacteria	T	Two component regulator propeller	pdtaS	-	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,Reg_prop,Y_Y_Y
CMS2_k127_5368552_14	903818.KI912268_gene1508	8.925e-61	241.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,3Y3MW@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,Response_reg
CMS2_k127_5368552_15	452637.Oter_2137	9.963e-61	221.0	COG2006@1|root,COG2006@2|Bacteria,46U2P@74201|Verrucomicrobia,3K77Y@414999|Opitutae	2|Bacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS2_k127_5368552_13	706587.Desti_2024	4.081e-63	244.0	COG0784@1|root,COG0834@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MQW1@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
CMS2_k127_5368552_12	706587.Desti_2024	8.747e-65	250.0	COG0784@1|root,COG0834@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MQW1@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
CMS2_k127_5368552_18	313606.M23134_03474	2.964e-34	153.0	COG0457@1|root,COG2208@1|root,COG0457@2|Bacteria,COG2208@2|Bacteria,4NUFW@976|Bacteroidetes,47TYP@768503|Cytophagia	976|Bacteroidetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,TPR_12
CMS2_k127_5368552_10	706587.Desti_2024	8.908e-70	252.0	COG0784@1|root,COG0834@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MQW1@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
CMS2_k127_5368552_5	945713.IALB_0467	5.263e-105	347.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
CMS2_k127_5368552_11	1499967.BAYZ01000193_gene3921	1.942e-65	234.0	COG0382@1|root,COG0382@2|Bacteria,2NNVJ@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	ubiA	-	-	-	-	-	-	-	-	-	-	-	UbiA
CMS2_k127_5368552_1	269797.Mbar_A0814	2.1e-259	805.0	COG0753@1|root,arCOG03310@2157|Archaea,2XTIP@28890|Euryarchaeota,2N957@224756|Methanomicrobia	224756|Methanomicrobia	P	Catalase	-	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
CMS2_k127_5368552_22	670487.Ocepr_1948	1.367e-24	108.0	COG0735@1|root,COG0735@2|Bacteria,1WJ7H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS2_k127_5368552_3	1121405.dsmv_2612	1.484e-140	454.0	COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,42Q93@68525|delta/epsilon subdivisions,2WKAA@28221|Deltaproteobacteria,2MJ2T@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
CMS2_k127_5368552_17	1499967.BAYZ01000143_gene6123	3.167e-56	201.0	COG4843@1|root,COG4843@2|Bacteria,2NPKB@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179
CMS2_k127_5368552_8	1047013.AQSP01000139_gene2346	7.133e-81	286.0	COG1215@1|root,COG1215@2|Bacteria,2NPD4@2323|unclassified Bacteria	2|Bacteria	M	PFAM Glycosyl transferase family 2	nodC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006082,GO:0006807,GO:0007155,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016051,GO:0016053,GO:0016740,GO:0016757,GO:0016758,GO:0019752,GO:0022607,GO:0022610,GO:0030198,GO:0030203,GO:0030212,GO:0030213,GO:0031224,GO:0031226,GO:0033692,GO:0034637,GO:0034645,GO:0042710,GO:0043062,GO:0043170,GO:0043436,GO:0044010,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0044764,GO:0045226,GO:0046379,GO:0046394,GO:0050501,GO:0051704,GO:0071704,GO:0071840,GO:0071944,GO:0085029,GO:0090605,GO:0090609,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903510	2.4.1.212	ko:K00752,ko:K14666	-	M00664	-	-	ko00000,ko00002,ko01000,ko01003,ko02000	4.D.1.1.10,4.D.1.1.4,4.D.1.1.5	GT2	-	Glyco_tranf_2_3,Glycos_transf_2
CMS2_k127_5372309_0	643867.Ftrac_2086	3.41e-26	109.0	COG3462@1|root,COG3462@2|Bacteria,4NVJQ@976|Bacteroidetes,47SHH@768503|Cytophagia	976|Bacteroidetes	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
CMS2_k127_5372309_2	1131814.JAFO01000001_gene102	4.22e-11	76.0	COG3391@1|root,COG3391@2|Bacteria,1MXJJ@1224|Proteobacteria,2TTH6@28211|Alphaproteobacteria,3EY9I@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase,NHL
CMS2_k127_5372309_1	1121875.KB907549_gene1905	9.263e-26	108.0	COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes,1I2XY@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
CMS2_k127_5372309_3	1046627.BZARG_1776	1.066e-07	53.0	COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes,1I2XY@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
CMS2_k127_5373607_15	177437.HRM2_34080	2.84e-54	216.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,1N26H@1224|Proteobacteria,43EV4@68525|delta/epsilon subdivisions,2WR4K@28221|Deltaproteobacteria,2MNP4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS2_k127_5373607_29	768671.ThimaDRAFT_4637	1.463e-20	108.0	COG1409@1|root,COG1409@2|Bacteria,1N8PY@1224|Proteobacteria,1SZFU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_5373607_0	925409.KI911562_gene1370	0.0	1372.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1IR3P@117747|Sphingobacteriia	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
CMS2_k127_5373607_8	179408.Osc7112_0240	7.937e-96	329.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1G2HS@1117|Cyanobacteria,1HDC4@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_1,Glycos_transf_2,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
CMS2_k127_5373607_32	266117.Rxyl_3109	5.975e-17	92.0	COG1216@1|root,COG1216@2|Bacteria,2HTM1@201174|Actinobacteria,4CPU8@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_5373607_2	886293.Sinac_0224	3.469e-166	532.0	COG0639@1|root,COG4639@1|root,COG0639@2|Bacteria,COG4639@2|Bacteria,2IXM8@203682|Planctomycetes	203682|Planctomycetes	T	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,Metallophos,PNKP-ligase_C,PNKP_ligase
CMS2_k127_5373607_1	1047013.AQSP01000139_gene2329	3.153e-200	649.0	COG2091@1|root,COG2091@2|Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_5373607_3	485917.Phep_4161	5.097e-144	498.0	COG0553@1|root,COG0553@2|Bacteria,4NG6P@976|Bacteroidetes,1IPUE@117747|Sphingobacteriia	976|Bacteroidetes	L	PFAM Helicase conserved C-terminal domain	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	Helicase_C,SNF2_N,SNF2_assoc
CMS2_k127_5373607_26	644282.Deba_1234	1.84e-21	96.0	COG1366@1|root,COG1366@2|Bacteria,1NDC7@1224|Proteobacteria,42XY3@68525|delta/epsilon subdivisions,2WSWC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS2_k127_5373607_28	644282.Deba_1234	2.895e-21	96.0	COG1366@1|root,COG1366@2|Bacteria,1NDC7@1224|Proteobacteria,42XY3@68525|delta/epsilon subdivisions,2WSWC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS2_k127_5373607_17	880073.Calab_2577	1.32e-47	191.0	COG2204@1|root,COG2208@1|root,COG2204@2|Bacteria,COG2208@2|Bacteria,2NQ3V@2323|unclassified Bacteria	2|Bacteria	KT	COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	CBS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE,dCache_1
CMS2_k127_5373607_14	1047013.AQSP01000135_gene1616	1.392e-56	206.0	COG0811@1|root,COG0811@2|Bacteria,2NPFR@2323|unclassified Bacteria	2|Bacteria	U	MotA/TolQ/ExbB proton channel family	tolQ	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
CMS2_k127_5373607_18	1047013.AQSP01000135_gene1615	4.83e-44	165.0	COG0848@1|root,COG0848@2|Bacteria,2NQ52@2323|unclassified Bacteria	2|Bacteria	U	Biopolymer transport protein ExbD/TolR	tolR	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
CMS2_k127_5373607_22	1047013.AQSP01000135_gene1614	1.067e-29	128.0	COG0810@1|root,COG0810@2|Bacteria,2NQ3G@2323|unclassified Bacteria	2|Bacteria	M	TonB C terminal	tonB	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2,TonB_C
CMS2_k127_5373607_4	1047013.AQSP01000135_gene1613	9.218e-138	451.0	COG0823@1|root,COG0823@2|Bacteria,2NNZC@2323|unclassified Bacteria	2|Bacteria	U	TolB amino-terminal domain	tolB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019534,GO:0019904,GO:0022857,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901998	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
CMS2_k127_5373607_12	1499967.BAYZ01000179_gene4620	1.643e-77	267.0	COG1794@1|root,COG1794@2|Bacteria,2NQIV@2323|unclassified Bacteria	2|Bacteria	M	Asp/Glu/Hydantoin racemase	MA20_00660	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS14520	Asp_Glu_race
CMS2_k127_5373607_23	1089548.KI783301_gene2326	6.441e-28	125.0	COG0400@1|root,COG0400@2|Bacteria,1V36F@1239|Firmicutes,4HFV0@91061|Bacilli	91061|Bacilli	S	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5373607_33	927658.AJUM01000024_gene2572	2.02e-13	70.0	COG0641@1|root,COG0641@2|Bacteria,4NG1N@976|Bacteroidetes,2FMBY@200643|Bacteroidia,3XJ3S@558415|Marinilabiliaceae	976|Bacteroidetes	C	Iron-sulfur cluster-binding domain	atsB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS2_k127_5373607_34	526222.Desal_1351	1.001e-11	66.0	COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,42PD2@68525|delta/epsilon subdivisions,2WJIK@28221|Deltaproteobacteria,2M7WH@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SEC-C,SPASM
CMS2_k127_5373607_31	269799.Gmet_3321	1.129e-18	94.0	COG4656@1|root,COG4656@2|Bacteria	2|Bacteria	C	electron transfer activity	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB
CMS2_k127_5373607_24	398767.Glov_1551	1.641e-27	120.0	COG1719@1|root,COG1719@2|Bacteria	2|Bacteria	KT	4-vinyl reductase, 4VR	-	-	-	ko:K07013,ko:K17763	-	-	-	-	ko00000,ko03021	-	-	-	V4R
CMS2_k127_5373607_27	593750.Metfor_1068	2.597e-21	103.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota,2NB1F@224756|Methanomicrobia	224756|Methanomicrobia	S	Roadblock LC7	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
CMS2_k127_5373607_25	1265505.ATUG01000002_gene1721	5.278e-27	112.0	2E4ZM@1|root,32ZT9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5373607_21	234267.Acid_5340	2.862e-32	144.0	COG0577@1|root,COG0577@2|Bacteria,3Y4J3@57723|Acidobacteria	57723|Acidobacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5373607_19	1267535.KB906767_gene1202	6.109e-39	153.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,DUF2505
CMS2_k127_5373607_9	555779.Dthio_PD3478	1.419e-88	303.0	COG2006@1|root,COG2006@2|Bacteria,1NV7D@1224|Proteobacteria,42ZEV@68525|delta/epsilon subdivisions,2WV1N@28221|Deltaproteobacteria,2M8BU@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS2_k127_5373607_11	1121904.ARBP01000009_gene4328	1.294e-77	282.0	COG4219@1|root,COG4219@2|Bacteria,4NKKC@976|Bacteroidetes,47JQV@768503|Cytophagia	976|Bacteroidetes	KT	PFAM Peptidase M56, BlaR1	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
CMS2_k127_5373607_16	1227739.Hsw_3216	9.356e-48	174.0	COG3682@1|root,COG3682@2|Bacteria,4NSQR@976|Bacteroidetes,47R7N@768503|Cytophagia	976|Bacteroidetes	K	PFAM Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS2_k127_5373607_10	309807.SRU_0260	2.105e-78	281.0	COG0815@1|root,COG0815@2|Bacteria,4NMJK@976|Bacteroidetes	976|Bacteroidetes	M	Carbon-nitrogen hydrolase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
CMS2_k127_5373607_6	344747.PM8797T_25491	1.131e-102	357.0	COG3653@1|root,COG3653@2|Bacteria,2IXWQ@203682|Planctomycetes	203682|Planctomycetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS2_k127_5373607_7	246194.CHY_1537	4.103e-99	334.0	COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia,42FQ8@68295|Thermoanaerobacterales	186801|Clostridia	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
CMS2_k127_5373607_5	641107.CDLVIII_1101	1.023e-115	383.0	COG0409@1|root,COG0409@2|Bacteria,1TPM7@1239|Firmicutes,248EX@186801|Clostridia,36FKI@31979|Clostridiaceae	186801|Clostridia	O	hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
CMS2_k127_5373607_30	1183377.Py04_0862	3.021e-19	89.0	COG0298@1|root,arCOG04427@2157|Archaea,2Y0AJ@28890|Euryarchaeota,244KI@183968|Thermococci	183968|Thermococci	O	HupF/HypC family	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
CMS2_k127_5373607_20	44251.PDUR_18895	1.868e-33	137.0	COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,4HCJG@91061|Bacilli,26WMT@186822|Paenibacillaceae	91061|Bacilli	O	Belongs to the carbamoyltransferase HypF family	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
CMS2_k127_5374623_4	373903.Hore_10320	1.229e-49	185.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,3WAJK@53433|Halanaerobiales	186801|Clostridia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
CMS2_k127_5374623_5	1121920.AUAU01000016_gene1278	1.294e-39	168.0	COG0840@1|root,COG2208@1|root,COG0840@2|Bacteria,COG2208@2|Bacteria,3Y2P9@57723|Acidobacteria	57723|Acidobacteria	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
CMS2_k127_5374623_2	1131462.DCF50_p1146	6.812e-135	443.0	COG1109@1|root,COG1109@2|Bacteria,1TS6S@1239|Firmicutes,2491F@186801|Clostridia,260X1@186807|Peptococcaceae	186801|Clostridia	G	alpha beta alpha domain I	manB	-	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS2_k127_5374623_6	944481.JAFP01000001_gene730	5.33e-30	122.0	COG2337@1|root,COG2337@2|Bacteria,1PVJA@1224|Proteobacteria,43E22@68525|delta/epsilon subdivisions,2X2GJ@28221|Deltaproteobacteria,2M7NU@213113|Desulfurellales	28221|Deltaproteobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PemK_toxin
CMS2_k127_5374623_0	1254432.SCE1572_31185	3.764e-292	921.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42Z54@68525|delta/epsilon subdivisions,2WUB9@28221|Deltaproteobacteria,2YYC4@29|Myxococcales	28221|Deltaproteobacteria	J	Anticodon-binding domain of tRNA	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
CMS2_k127_5374623_3	1121904.ARBP01000011_gene1546	1.597e-61	218.0	COG2017@1|root,COG2017@2|Bacteria,4NF5G@976|Bacteroidetes,47KAR@768503|Cytophagia	976|Bacteroidetes	G	Converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
CMS2_k127_5377945_0	754476.Q7A_2990	0.0	1506.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,4600V@72273|Thiotrichales	72273|Thiotrichales	E	Vitamin B12 dependent methionine synthase, activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
CMS2_k127_5377945_1	1168034.FH5T_20565	0.0	1232.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
CMS2_k127_5377945_13	1397527.Q670_11950	6.339e-72	254.0	COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,1RR31@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_5377945_16	762983.HMPREF9444_01479	1.364e-58	212.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1Y3RG@135624|Aeromonadales	135624|Aeromonadales	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
CMS2_k127_5377945_7	65093.PCC7418_2468	4.196e-119	400.0	COG0612@1|root,COG0612@2|Bacteria,1G1CD@1117|Cyanobacteria	1117|Cyanobacteria	S	Belongs to the peptidase M16 family	pqqE	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_5377945_10	489825.LYNGBM3L_18880	1.128e-92	331.0	COG0612@1|root,COG0612@2|Bacteria,1G303@1117|Cyanobacteria,1H8AE@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Peptidase M16 inactive domain	ymxG	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_5377945_8	635013.TherJR_2333	5.414e-113	377.0	COG3434@1|root,COG3434@2|Bacteria,1TPWC@1239|Firmicutes,248M1@186801|Clostridia,26466@186807|Peptococcaceae	186801|Clostridia	T	signal transduction protein containing EAL and modified HD-GYP	-	-	-	-	-	-	-	-	-	-	-	-	EAL,HDOD
CMS2_k127_5377945_24	329726.AM1_3757	5.234e-06	54.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
CMS2_k127_5377945_14	398767.Glov_1885	8.599e-66	234.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WN4E@28221|Deltaproteobacteria,43THN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
CMS2_k127_5377945_20	382464.ABSI01000006_gene874	1.432e-24	111.0	COG1595@1|root,COG1595@2|Bacteria,46XM2@74201|Verrucomicrobia,2IW65@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_5377945_19	1267534.KB906759_gene1760	1.104e-24	120.0	COG0577@1|root,COG0577@2|Bacteria,3Y4J3@57723|Acidobacteria,2JJDG@204432|Acidobacteriia	204432|Acidobacteriia	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5377945_21	1123278.KB893458_gene719	5.895e-20	100.0	COG2819@1|root,COG2819@2|Bacteria,4NGNJ@976|Bacteroidetes	976|Bacteroidetes	S	Putative esterase	-	-	-	ko:K07017	-	-	-	-	ko00000	-	-	-	Esterase
CMS2_k127_5377945_5	945713.IALB_1080	3.861e-214	670.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_5377945_2	945713.IALB_1079	7.619e-281	871.0	COG1866@1|root,COG1866@2|Bacteria	2|Bacteria	H	phosphoenolpyruvate carboxykinase (ATP) activity	pckA	GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
CMS2_k127_5377945_12	1047013.AQSP01000070_gene47	1.462e-81	277.0	COG0637@1|root,COG0637@2|Bacteria,2NQ0R@2323|unclassified Bacteria	2|Bacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.96	ko:K17623	-	-	R11180	RC00017	ko00000,ko01000,ko01009	-	-	-	HAD_2
CMS2_k127_5377945_6	1047013.AQSP01000111_gene1664	4.777e-208	651.0	COG0473@1|root,COG0473@2|Bacteria,2NP0Z@2323|unclassified Bacteria	2|Bacteria	CE	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.41,1.1.1.85	ko:K00030,ko:K00052	ko00020,ko00290,ko00660,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00660,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00432,M00535	R00709,R00994,R04426,R10052	RC00084,RC00114,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CMS2_k127_5377945_9	694431.DESACE_02010	5.457e-109	361.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,2M6TW@213113|Desulfurellales	28221|Deltaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
CMS2_k127_5377945_4	945713.IALB_2672	1.205e-229	716.0	COG0372@1|root,COG0372@2|Bacteria	2|Bacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
CMS2_k127_5377945_18	351607.Acel_0019	5.412e-45	186.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4EX2B@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_5377945_11	1121946.AUAX01000016_gene4670	8.162e-84	308.0	COG3188@1|root,COG5297@1|root,COG3188@2|Bacteria,COG5297@2|Bacteria,2HQZC@201174|Actinobacteria,4DMG6@85008|Micromonosporales	201174|Actinobacteria	NU	Glycosyl hydrolase family 48	cbhB	-	-	-	-	-	-	-	-	-	-	-	CBM_2,Glyco_hydro_48
CMS2_k127_5377945_22	1535422.ND16A_1818	4.47e-18	100.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1MU3S@1224|Proteobacteria,1RWN2@1236|Gammaproteobacteria,2Q85J@267889|Colwelliaceae	1236|Gammaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS2_k127_5377945_17	1047013.AQSP01000139_gene2383	1.883e-49	194.0	COG0457@1|root,COG0484@1|root,COG0457@2|Bacteria,COG0484@2|Bacteria,2NRMR@2323|unclassified Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	ko:K05516,ko:K05801	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DUF4388,DnaJ,DnaJ_C,TerB,WD40
CMS2_k127_5377945_3	1265505.ATUG01000001_gene3461	7.439e-238	749.0	28MMZ@1|root,2ZAXK@2|Bacteria,1R7WU@1224|Proteobacteria,42QIC@68525|delta/epsilon subdivisions,2WKJJ@28221|Deltaproteobacteria,2MJD3@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5377945_15	1232430.CAVG010000025_gene249	7.16e-63	222.0	COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,4H9Y0@91061|Bacilli,4GXJI@90964|Staphylococcaceae	91061|Bacilli	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS11010	UPRTase
CMS2_k127_5377945_23	525904.Tter_2109	3.2e-13	81.0	COG1470@1|root,COG3664@1|root,COG1470@2|Bacteria,COG3664@2|Bacteria,2NQ48@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolases family 39	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,NPCBM_assoc,PEGA
CMS2_k127_5381865_0	649747.HMPREF0083_00279	0.0	1061.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16123,ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5395074_0	1469607.KK073768_gene813	1.601e-14	88.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G2QK@1117|Cyanobacteria,1HM44@1161|Nostocales	1117|Cyanobacteria	LO	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,CHAT,TPR_12,TPR_7
CMS2_k127_540476_2	1429046.RR21198_2161	3.86e-06	51.0	2E98C@1|root,333GS@2|Bacteria,2GSI7@201174|Actinobacteria,4G42Z@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4177)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4177
CMS2_k127_540476_1	880070.Cycma_4293	3.382e-72	256.0	COG0582@1|root,COG0582@2|Bacteria,4PKC8@976|Bacteroidetes,47N2F@768503|Cytophagia	976|Bacteroidetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_5,Phage_int_SAM_5,Phage_integrase
CMS2_k127_540476_0	755731.Clo1100_1301	2.747e-171	563.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,Thioesterase,ketoacyl-synt
CMS2_k127_5410152_3	96561.Dole_2867	5.88e-27	119.0	2EJPK@1|root,33DEE@2|Bacteria,1NF1Y@1224|Proteobacteria,42VT1@68525|delta/epsilon subdivisions,2WS2W@28221|Deltaproteobacteria,2MPD5@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5410152_7	1121948.AUAC01000008_gene786	5.824e-10	68.0	2CK46@1|root,337US@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
CMS2_k127_5410152_8	1235792.C808_00789	1.412e-09	64.0	COG1476@1|root,COG1476@2|Bacteria,1VHT2@1239|Firmicutes,25FFD@186801|Clostridia,27PG5@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS2_k127_5410152_1	1168034.FH5T_07730	1.895e-125	424.0	COG0745@1|root,COG1879@1|root,COG5002@1|root,COG0745@2|Bacteria,COG1879@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,2FWSR@200643|Bacteroidia	976|Bacteroidetes	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Peripla_BP_4,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_5410152_11	439235.Dalk_1389	8.024e-06	59.0	COG2885@1|root,COG3203@1|root,COG4719@1|root,COG2885@2|Bacteria,COG3203@2|Bacteria,COG4719@2|Bacteria,1QW22@1224|Proteobacteria,42NCQ@68525|delta/epsilon subdivisions,2WMJP@28221|Deltaproteobacteria,2MMHS@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,OmpA
CMS2_k127_5410152_4	452652.KSE_02960	2.58e-19	104.0	COG3405@1|root,COG3979@1|root,COG3405@2|Bacteria,COG3979@2|Bacteria,2GKPY@201174|Actinobacteria,2M4KM@2063|Kitasatospora	201174|Actinobacteria	G	Glycosyl hydrolases family 8	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_8
CMS2_k127_5410152_6	313596.RB2501_13489	5.696e-13	83.0	COG3055@1|root,COG3291@1|root,COG3055@2|Bacteria,COG3291@2|Bacteria,4NHHD@976|Bacteroidetes,1HWPE@117743|Flavobacteriia	976|Bacteroidetes	M	Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Kelch_1,Kelch_6,Malectin,PKD
CMS2_k127_5410152_5	1121382.JQKG01000011_gene619	1.778e-18	102.0	COG1361@1|root,COG1361@2|Bacteria,1WI4N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	TIGRFAM conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
CMS2_k127_5410152_2	439235.Dalk_4228	8.566e-58	235.0	COG1361@1|root,COG1572@1|root,COG1361@2|Bacteria,COG1572@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
CMS2_k127_5410152_9	927658.AJUM01000022_gene1003	1.826e-07	68.0	COG1361@1|root,COG2304@1|root,COG5184@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG5184@2|Bacteria,4NMB8@976|Bacteroidetes,2G13I@200643|Bacteroidia,3XJY5@558415|Marinilabiliaceae	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
CMS2_k127_5410152_0	1121904.ARBP01000005_gene4786	1.857e-236	741.0	COG2986@1|root,COG2986@2|Bacteria,4NE0D@976|Bacteroidetes,47MP5@768503|Cytophagia	976|Bacteroidetes	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
CMS2_k127_5412578_24	1121104.AQXH01000001_gene1459	6.318e-106	379.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,4NRVM@976|Bacteroidetes,1IQDC@117747|Sphingobacteriia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
CMS2_k127_5412578_25	1123376.AUIU01000016_gene233	2.519e-101	345.0	COG2204@1|root,COG2204@2|Bacteria,3J0ZU@40117|Nitrospirae	40117|Nitrospirae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_5412578_12	926569.ANT_03820	8.491e-167	531.0	COG2006@1|root,COG2006@2|Bacteria,2G7GH@200795|Chloroflexi	200795|Chloroflexi	S	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5412578_22	1443125.Z962_11095	1.869e-116	391.0	COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,248V4@186801|Clostridia,36DV2@31979|Clostridiaceae	186801|Clostridia	M	membrane protein involved in D-alanine export	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
CMS2_k127_5412578_26	335543.Sfum_0520	1.743e-96	322.0	COG1878@1|root,COG1878@2|Bacteria,1P8U5@1224|Proteobacteria,42SY1@68525|delta/epsilon subdivisions,2WPQ7@28221|Deltaproteobacteria,2MSBX@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Putative cyclase	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
CMS2_k127_5412578_39	1047013.AQSP01000139_gene2343	1.265e-66	230.0	COG2080@1|root,COG2080@2|Bacteria,2NPPX@2323|unclassified Bacteria	2|Bacteria	C	PFAM 2Fe-2S -binding	-	-	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
CMS2_k127_5412578_0	1047013.AQSP01000139_gene2342	2.802e-266	840.0	COG1529@1|root,COG1529@2|Bacteria,2NPHP@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS2_k127_5412578_76	1408433.JHXV01000043_gene3000	4.74e-15	87.0	COG2849@1|root,COG2849@2|Bacteria,4NMDX@976|Bacteroidetes,1I51X@117743|Flavobacteriia	976|Bacteroidetes	M	PFAM MORN repeat variant	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2,TPR_1,TPR_8
CMS2_k127_5412578_54	1123277.KB893192_gene4330	2.804e-50	194.0	COG4099@1|root,COG4099@2|Bacteria,4NFSH@976|Bacteroidetes,47REE@768503|Cytophagia	976|Bacteroidetes	M	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Esterase_phd,Peptidase_S9
CMS2_k127_5412578_71	1297742.A176_04979	1.981e-23	104.0	COG1652@1|root,COG1652@2|Bacteria	2|Bacteria	S	positive regulation of growth rate	ygaU	GO:0003674,GO:0005488,GO:0008150,GO:0010035,GO:0010038,GO:0030955,GO:0031420,GO:0035864,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896	-	-	-	-	-	-	-	-	-	-	BON,LysM
CMS2_k127_5412578_37	1047013.AQSP01000110_gene78	8.776e-70	248.0	COG0130@1|root,COG0130@2|Bacteria,2NP9J@2323|unclassified Bacteria	2|Bacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177,ko:K03483	-	-	-	-	ko00000,ko01000,ko03000,ko03016	-	-	iSB619.SA_RS06305	TruB-C_2,TruB_C_2,TruB_N
CMS2_k127_5412578_35	1047013.AQSP01000110_gene77	4.495e-72	254.0	COG0618@1|root,COG0618@2|Bacteria,2NPK0@2323|unclassified Bacteria	2|Bacteria	S	DHH family	nrnA	GO:0008150,GO:0040007	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
CMS2_k127_5412578_82	1121085.AUCI01000008_gene726	1.411e-11	69.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,4HII1@91061|Bacilli,1ZGB3@1386|Bacillus	91061|Bacilli	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
CMS2_k127_5412578_74	1158345.JNLL01000001_gene299	4.861e-17	83.0	COG1550@1|root,COG1550@2|Bacteria,2G47V@200783|Aquificae	200783|Aquificae	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
CMS2_k127_5412578_13	1234664.AMRO01000072_gene3533	3.848e-164	547.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,4HA8S@91061|Bacilli,1WFHA@129337|Geobacillus	91061|Bacilli	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
CMS2_k127_5412578_29	1121396.KB892901_gene2192	4.599e-83	287.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria,2MHW6@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
CMS2_k127_5412578_40	883110.HMPREF9260_00243	2.325e-60	229.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,4H9U4@91061|Bacilli,27DNP@186827|Aerococcaceae	91061|Bacilli	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
CMS2_k127_5412578_3	1123008.KB905699_gene1915	1.432e-224	714.0	COG1164@1|root,COG1164@2|Bacteria,4NFV3@976|Bacteroidetes,2FMG8@200643|Bacteroidia,22XF5@171551|Porphyromonadaceae	976|Bacteroidetes	E	Oligoendopeptidase f	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5412578_5	1089455.MOPEL_029_00190	8.772e-204	645.0	COG0174@1|root,COG0174@2|Bacteria,2GMN1@201174|Actinobacteria,4F6MK@85018|Dermatophilaceae	201174|Actinobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
CMS2_k127_5412578_69	1089552.KI911559_gene239	1.353e-27	113.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2UBRZ@28211|Alphaproteobacteria,2JT89@204441|Rhodospirillales	204441|Rhodospirillales	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
CMS2_k127_5412578_2	1047013.AQSP01000085_gene1987	4.929e-225	717.0	COG1185@1|root,COG1185@2|Bacteria,2NNX7@2323|unclassified Bacteria	2|Bacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
CMS2_k127_5412578_53	1047013.AQSP01000085_gene1986	1.48e-50	183.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	pulG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
CMS2_k127_5412578_67	243090.RB12541	1.467e-29	132.0	COG0526@1|root,COG0526@2|Bacteria,2J35Z@203682|Planctomycetes	203682|Planctomycetes	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
CMS2_k127_5412578_36	1121930.AQXG01000005_gene639	2.548e-71	256.0	COG0836@1|root,COG0836@2|Bacteria,4NE1Y@976|Bacteroidetes	976|Bacteroidetes	M	mannose-1-phosphate guanylyltransferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CMS2_k127_5412578_66	1047013.AQSP01000075_gene1430	2.921e-30	134.0	COG0392@1|root,COG0392@2|Bacteria,2NRST@2323|unclassified Bacteria	2|Bacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS2_k127_5412578_8	1124780.ANNU01000048_gene2125	2.448e-184	586.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,47NI8@768503|Cytophagia	976|Bacteroidetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_5412578_15	1048983.EL17_22160	2.597e-160	518.0	COG0612@1|root,COG0612@2|Bacteria,4NEPT@976|Bacteroidetes,47NZ1@768503|Cytophagia	976|Bacteroidetes	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_5412578_60	588581.Cpap_1724	7.573e-39	149.0	COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,24MUB@186801|Clostridia,3WK48@541000|Ruminococcaceae	186801|Clostridia	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
CMS2_k127_5412578_79	644282.Deba_1234	2.182e-14	76.0	COG1366@1|root,COG1366@2|Bacteria,1NDC7@1224|Proteobacteria,42XY3@68525|delta/epsilon subdivisions,2WSWC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS2_k127_5412578_7	1047013.AQSP01000134_gene1355	5.932e-191	613.0	COG2414@1|root,COG2414@2|Bacteria,2NP2Q@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS2_k127_5412578_56	1296416.JACB01000036_gene2847	1.013e-47	180.0	COG1414@1|root,COG1414@2|Bacteria,4NHTZ@976|Bacteroidetes,1I3H4@117743|Flavobacteriia,2YGH6@290174|Aquimarina	976|Bacteroidetes	K	helix_turn_helix isocitrate lyase regulation	-	-	-	ko:K13641,ko:K19333	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
CMS2_k127_5412578_16	1265505.ATUG01000001_gene3075	5.004e-145	471.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_5412578_18	1191523.MROS_0241	4.788e-138	446.0	COG0460@1|root,COG0460@2|Bacteria	2|Bacteria	E	homoserine dehydrogenase activity	hom	-	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
CMS2_k127_5412578_84	161156.JQKW01000007_gene847	9.069e-08	57.0	COG2331@1|root,COG2331@2|Bacteria,2GI1M@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
CMS2_k127_5412578_68	1449126.JQKL01000002_gene1553	1.054e-28	121.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	hybD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
CMS2_k127_5412578_89	351627.Csac_0249	0.0004512	44.0	COG5464@1|root,COG5464@2|Bacteria	2|Bacteria	S	double-stranded DNA endodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_5412578_50	1168034.FH5T_04930	7.218e-52	187.0	COG4635@1|root,COG4635@2|Bacteria,4PK9I@976|Bacteroidetes,2FZ54@200643|Bacteroidia	976|Bacteroidetes	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
CMS2_k127_5412578_80	694431.DESACE_00770	2.247e-13	80.0	COG1280@1|root,COG1280@2|Bacteria,1QT7A@1224|Proteobacteria,43438@68525|delta/epsilon subdivisions,2X50X@28221|Deltaproteobacteria,2M7N4@213113|Desulfurellales	28221|Deltaproteobacteria	E	SPTR Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
CMS2_k127_5412578_38	1090318.ATTI01000001_gene1160	9.758e-69	243.0	COG1215@1|root,COG1215@2|Bacteria,1R6C4@1224|Proteobacteria,2UAG0@28211|Alphaproteobacteria,2K0HN@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_5412578_31	1089550.ATTH01000001_gene1757	4.162e-82	281.0	COG0463@1|root,COG0463@2|Bacteria,4NX3Y@976|Bacteroidetes,1FJXM@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_24
CMS2_k127_5412578_43	391596.PBAL39_20344	1.468e-57	231.0	COG0745@1|root,COG0745@2|Bacteria,4P071@976|Bacteroidetes,1IVTF@117747|Sphingobacteriia	976|Bacteroidetes	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
CMS2_k127_5412578_6	1443665.JACA01000052_gene1875	9.044e-198	675.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,1HZEZ@117743|Flavobacteriia,2YKIU@290174|Aquimarina	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_5412578_4	1047013.AQSP01000110_gene58	4.025e-217	694.0	COG0247@1|root,COG0247@2|Bacteria,2NNXS@2323|unclassified Bacteria	2|Bacteria	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
CMS2_k127_5412578_72	760142.Hipma_1126	8.497e-22	109.0	COG1572@1|root,COG1572@2|Bacteria,1NZY8@1224|Proteobacteria,431Z8@68525|delta/epsilon subdivisions,2WWU7@28221|Deltaproteobacteria,2M7PM@213113|Desulfurellales	28221|Deltaproteobacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5412578_77	357808.RoseRS_1670	5.584e-15	88.0	COG0515@1|root,COG1470@1|root,COG1716@1|root,COG0515@2|Bacteria,COG1470@2|Bacteria,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	2.7.11.1,3.2.1.50	ko:K01205,ko:K07004,ko:K12132	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078	R07816	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko04147	-	-	-	DUF3662,DUF916,FHA,NAGLU,NAGLU_C,NAGLU_N,Yop-YscD_cpl
CMS2_k127_5412578_1	929556.Solca_1235	7.471e-248	787.0	COG0160@1|root,COG2334@1|root,COG0160@2|Bacteria,COG2334@2|Bacteria,4NFMP@976|Bacteroidetes,1IWK9@117747|Sphingobacteriia	976|Bacteroidetes	E	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH,Aminotran_3,Peptidase_M23
CMS2_k127_5412578_19	1185876.BN8_06082	4.805e-131	434.0	COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,47KDQ@768503|Cytophagia	976|Bacteroidetes	M	MBOAT, membrane-bound O-acyltransferase family	algI	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
CMS2_k127_5412578_49	596152.DesU5LDRAFT_3864	1.435e-52	207.0	COG0457@1|root,COG0457@2|Bacteria,1RIYN@1224|Proteobacteria,42T31@68525|delta/epsilon subdivisions,2WPYY@28221|Deltaproteobacteria,2M990@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	SGNH hydrolase-like domain, acetyltransferase AlgX	-	-	-	-	-	-	-	-	-	-	-	-	ALGX
CMS2_k127_5412578_11	1047013.AQSP01000072_gene986	1.376e-169	557.0	COG5000@1|root,COG5000@2|Bacteria,2NQRV@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	ntrY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
CMS2_k127_5412578_23	439235.Dalk_0237	2.011e-109	380.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_5412578_41	1235457.C404_13715	3.407e-60	233.0	COG2342@1|root,COG2342@2|Bacteria,1N2HD@1224|Proteobacteria,2W5MT@28216|Betaproteobacteria,1K6RZ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Glycoside-hydrolase family GH114	-	-	6.1.1.16	ko:K01884	ko00970,map00970	M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Glyco_hydro_114
CMS2_k127_5412578_30	1237149.C900_05924	5.844e-83	286.0	COG0823@1|root,COG0823@2|Bacteria,4NIV7@976|Bacteroidetes,47RCS@768503|Cytophagia	976|Bacteroidetes	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
CMS2_k127_5412578_78	290397.Adeh_3571	8.709e-15	81.0	COG1664@1|root,COG1664@2|Bacteria,1RHS7@1224|Proteobacteria,433TD@68525|delta/epsilon subdivisions,2X9WK@28221|Deltaproteobacteria,2YVM0@29|Myxococcales	28221|Deltaproteobacteria	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
CMS2_k127_5412578_58	635013.TherJR_1234	2.547e-43	166.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,260CP@186807|Peptococcaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.24	ko:K02032,ko:K10823,ko:K10824	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439,M00440	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS2_k127_5412578_17	1232437.KL662001_gene4590	4.852e-139	456.0	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42NMK@68525|delta/epsilon subdivisions,2WK6K@28221|Deltaproteobacteria,2MJD2@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_5412578_20	1304885.AUEY01000008_gene2092	2.144e-128	436.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MJ2F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,GAF_2,HATPase_c,HisKA,PAS_3,PAS_8,PAS_9,Response_reg
CMS2_k127_5412578_57	1198452.Jab_2c19300	3.29e-45	188.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VMUZ@28216|Betaproteobacteria,475JP@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4
CMS2_k127_5412578_32	1232437.KL662001_gene4589	5.231e-82	302.0	COG2197@1|root,COG4191@1|root,COG2197@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria,2MJZM@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
CMS2_k127_5412578_63	985762.SAGN_01355	2.884e-34	151.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,4H9WW@91061|Bacilli,4GWX7@90964|Staphylococcaceae	91061|Bacilli	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
CMS2_k127_5412578_44	1304888.ATWF01000001_gene928	3.04e-57	206.0	COG1573@1|root,COG1573@2|Bacteria,2GFD7@200930|Deferribacteres	200930|Deferribacteres	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS2_k127_5412578_51	1294142.CINTURNW_2159	4.207e-51	188.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,36DPK@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
CMS2_k127_5412578_52	986075.CathTA2_1900	8.02e-51	185.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,4HAK8@91061|Bacilli	91061|Bacilli	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
CMS2_k127_5412578_55	941824.TCEL_01796	2.213e-49	183.0	COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia,36EVE@31979|Clostridiaceae	186801|Clostridia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
CMS2_k127_5412578_75	944481.JAFP01000001_gene554	2.844e-16	81.0	COG2052@1|root,COG2052@2|Bacteria,1N0KP@1224|Proteobacteria,42TSK@68525|delta/epsilon subdivisions,2WQHH@28221|Deltaproteobacteria,2M7FH@213113|Desulfurellales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF370)	-	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
CMS2_k127_5412578_61	1047013.AQSP01000124_gene2669	4.698e-37	151.0	COG1561@1|root,COG1561@2|Bacteria,2NPG5@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF1732)	yicC	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
CMS2_k127_5412578_14	1047013.AQSP01000124_gene2668	5.391e-162	529.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	msbA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02021,ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	iJN746.PP_4935,iPC815.YPO1395,iUMN146_1321.UM146_12980	ABC_membrane,ABC_tran
CMS2_k127_5412578_65	944480.ATUV01000001_gene676	1.185e-33	140.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,42QV4@68525|delta/epsilon subdivisions,2WMR6@28221|Deltaproteobacteria,2M6ZU@213113|Desulfurellales	28221|Deltaproteobacteria	I	CDP-alcohol phosphatidyltransferase	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
CMS2_k127_5412578_88	1499967.BAYZ01000122_gene3369	8.529e-05	48.0	2DRP0@1|root,33CFM@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF465)	-	-	-	ko:K09794	-	-	-	-	ko00000	-	-	-	DUF465
CMS2_k127_5412578_70	1089553.Tph_c27600	1.657e-25	116.0	COG1410@1|root,COG1410@2|Bacteria,1V0F4@1239|Firmicutes,25CEI@186801|Clostridia,42G54@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM dihydropteroate synthase, DHPS	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CMS2_k127_5412578_33	445335.CBN_1203	7.34e-74	259.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia,36DCU@31979|Clostridiaceae	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS2_k127_5412578_21	880073.Calab_0451	5.491e-127	415.0	COG1932@1|root,COG1932@2|Bacteria,2NNYA@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
CMS2_k127_5412578_34	644282.Deba_2308	4.428e-73	255.0	COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,42PR1@68525|delta/epsilon subdivisions,2WIQ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
CMS2_k127_5412578_87	1196031.ALEG01000064_gene3557	2.769e-06	57.0	COG1360@1|root,COG1360@2|Bacteria,1V8KE@1239|Firmicutes,4H9MD@91061|Bacilli,1ZQQB@1386|Bacillus	91061|Bacilli	N	Flagellar motor protein	ytxE	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
CMS2_k127_5412578_73	207559.Dde_3587	7.435e-21	100.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,42Q7D@68525|delta/epsilon subdivisions,2WKIT@28221|Deltaproteobacteria,2MG6S@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	Membrane MotB of proton-channel complex MotA/MotB	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
CMS2_k127_5412578_81	1121406.JAEX01000013_gene1282	3.124e-12	74.0	COG1580@1|root,COG1580@2|Bacteria,1NBUX@1224|Proteobacteria,42RSV@68525|delta/epsilon subdivisions,2WR7K@28221|Deltaproteobacteria,2MBZ2@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
CMS2_k127_5412578_83	667014.Thein_0181	2.091e-08	59.0	COG1886@1|root,COG1886@2|Bacteria,2GHQT@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	N	Type III flagellar switch regulator (C-ring) FliN C-term	-	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
CMS2_k127_5412578_47	357809.Cphy_2694	1.448e-53	205.0	COG1419@1|root,COG1419@2|Bacteria,1TSP7@1239|Firmicutes,249R1@186801|Clostridia	186801|Clostridia	N	PFAM GTP-binding signal recognition particle SRP54 G- domain	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
CMS2_k127_5412578_45	338966.Ppro_3446	4.081e-55	203.0	COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42PF7@68525|delta/epsilon subdivisions,2WJB5@28221|Deltaproteobacteria,43TCC@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Cellulose biosynthesis protein BcsQ	flhG	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
CMS2_k127_5412578_46	903818.KI912268_gene3353	1.181e-53	197.0	COG1191@1|root,COG1191@2|Bacteria,3Y4Q5@57723|Acidobacteria	57723|Acidobacteria	K	TIGRFAM RNA polymerase sigma factor, FliA WhiG family	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS2_k127_5412578_28	903818.KI912268_gene3354	2.078e-89	305.0	COG1868@1|root,COG1868@2|Bacteria,3Y49R@57723|Acidobacteria	57723|Acidobacteria	N	flagellar motor switch protein FliM	-	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
CMS2_k127_5412578_64	639282.DEFDS_0421	3.983e-34	142.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,2GFFH@200930|Deferribacteres	200930|Deferribacteres	N	Type III flagellar switch regulator (C-ring) FliN C-term	-	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
CMS2_k127_5412578_42	1307759.JOMJ01000003_gene38	6.228e-58	211.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42QJT@68525|delta/epsilon subdivisions,2WJ1S@28221|Deltaproteobacteria,2M8MF@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
CMS2_k127_5412578_59	903818.KI912269_gene270	1.27e-39	159.0	COG1639@1|root,COG1639@2|Bacteria,3Y8JW@57723|Acidobacteria	57723|Acidobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
CMS2_k127_5412578_62	269799.Gmet_3268	1.385e-36	150.0	COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WQQK@28221|Deltaproteobacteria,43UEV@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Metal-dependent phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
CMS2_k127_5412578_86	390874.Tpet_0090	2.143e-06	59.0	COG2804@1|root,COG2804@2|Bacteria,2GCDW@200918|Thermotogae	200918|Thermotogae	NU	PFAM type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
CMS2_k127_5412578_9	518766.Rmar_2149	4.15e-180	587.0	COG3968@1|root,COG3968@2|Bacteria,4NG2B@976|Bacteroidetes	976|Bacteroidetes	S	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
CMS2_k127_5412578_48	359.CN09_31270	5.751e-53	199.0	COG1073@1|root,COG1073@2|Bacteria,1PT5B@1224|Proteobacteria,2V535@28211|Alphaproteobacteria,4BG48@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Peptidase_S15
CMS2_k127_5417050_2	573061.Clocel_2487	0.0	1278.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5417050_0	755731.Clo1100_2633	0.0	2014.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_5417050_4	945713.IALB_2223	3.253e-18	92.0	2B9NZ@1|root,3231D@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1579)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1579
CMS2_k127_5417050_1	755731.Clo1100_1301	0.0	1362.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,Thioesterase,ketoacyl-synt
CMS2_k127_5417050_3	394503.Ccel_0974	4.115e-164	545.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	6.1.1.13	ko:K03367	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	M00725	R02718	RC00037,RC00094	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NAD_binding_4,PP-binding,ketoacyl-synt
CMS2_k127_5417515_25	518637.EUBIFOR_00706	1.698e-60	235.0	COG1337@1|root,COG1337@2|Bacteria,1V7HY@1239|Firmicutes	1239|Firmicutes	L	CRISPR-associated RAMP protein	-	-	-	ko:K19134	-	-	-	-	ko00000,ko02048	-	-	-	RAMPs
CMS2_k127_5417515_22	1209989.TepiRe1_0129	6.946e-65	243.0	COG1353@1|root,COG1353@2|Bacteria,1UZM3@1239|Firmicutes,24KWD@186801|Clostridia,42FCY@68295|Thermoanaerobacterales	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5417515_29	865861.AZSU01000002_gene2796	6.267e-40	164.0	28I2A@1|root,2Z86H@2|Bacteria,1UZT2@1239|Firmicutes,24DJ9@186801|Clostridia,36U0S@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1887
CMS2_k127_5417515_30	748449.Halha_1115	5.58e-35	146.0	COG5464@1|root,COG5464@2|Bacteria,1UGME@1239|Firmicutes,248B2@186801|Clostridia	186801|Clostridia	S	transposase, YhgA-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
CMS2_k127_5417515_6	1034807.FBFL15_2654	2.062e-137	449.0	COG1373@1|root,COG1373@2|Bacteria,4NHQG@976|Bacteroidetes,1I2E3@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_5417515_33	272123.Anacy_4728	2.418e-29	122.0	COG5378@1|root,COG5378@2|Bacteria,1G6U9@1117|Cyanobacteria	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_2
CMS2_k127_5417515_49	385682.AFSL01000048_gene514	0.0009065	44.0	2ESGF@1|root,33K15@2|Bacteria,4NZCB@976|Bacteroidetes,2G1K5@200643|Bacteroidia,3XKZ9@558415|Marinilabiliaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5417515_47	1047013.AQSP01000142_gene124	0.0001305	53.0	COG3391@1|root,COG3391@2|Bacteria,2NQ4G@2323|unclassified Bacteria	2|Bacteria	O	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,NHL,TolB_like
CMS2_k127_5417515_39	1392502.JNIO01000008_gene2144	7.137e-15	85.0	COG1459@1|root,COG1459@2|Bacteria,1TQRZ@1239|Firmicutes,4H3DH@909932|Negativicutes	909932|Negativicutes	NU	Type II secretion system	gspF	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
CMS2_k127_5417515_41	338963.Pcar_0192	1.328e-12	79.0	COG2041@1|root,COG2875@1|root,COG2041@2|Bacteria,COG2875@2|Bacteria	2|Bacteria	H	precorrin-4 C11-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	SLH,TP_methylase
CMS2_k127_5417515_3	909663.KI867150_gene678	2.6e-192	613.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2MR7G@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CMS2_k127_5417515_20	309799.DICTH_0588	8.135e-72	252.0	COG0157@1|root,COG0157@2|Bacteria	2|Bacteria	H	quinolinate catabolic process	nadC	GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1988,iHN637.CLJU_RS12010,iLJ478.TM1645	QRPTase_C,QRPTase_N
CMS2_k127_5417515_1	525904.Tter_0977	0.0	1124.0	COG0060@1|root,COG0060@2|Bacteria,2NNT5@2323|unclassified Bacteria	2|Bacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_0027,iPC815.YPO0475	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
CMS2_k127_5417515_26	1173021.ALWA01000003_gene3360	5.335e-58	209.0	COG1656@1|root,COG1656@2|Bacteria,1G344@1117|Cyanobacteria	1117|Cyanobacteria	S	Mut7-C ubiquitin	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
CMS2_k127_5417515_10	439235.Dalk_0237	6.506e-113	383.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_5417515_8	313606.M23134_07246	1.405e-131	459.0	COG2203@1|root,COG2208@1|root,COG3292@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3292@2|Bacteria,4NKGA@976|Bacteroidetes,47TQU@768503|Cytophagia	976|Bacteroidetes	T	Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,SpoIIE,Y_Y_Y
CMS2_k127_5417515_28	1120973.AQXL01000131_gene2130	1.703e-50	207.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,277VY@186823|Alicyclobacillaceae	91061|Bacilli	KLT	Serine/Threonine protein kinases, catalytic domain	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_5417515_38	1304874.JAFY01000005_gene1635	9.25e-17	87.0	2CK23@1|root,33ZX0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5417515_43	500640.CIT292_09200	3.191e-08	67.0	COG0846@1|root,COG0846@2|Bacteria,1MXU2@1224|Proteobacteria,1SJ5U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2
CMS2_k127_5417515_19	335543.Sfum_3765	2.64e-72	268.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MQ9H@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	fgrM	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_5417515_5	1158338.JNLJ01000001_gene1120	5.529e-141	455.0	COG0057@1|root,COG0057@2|Bacteria,2G3TK@200783|Aquificae	200783|Aquificae	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
CMS2_k127_5417515_7	204669.Acid345_2542	1.467e-132	433.0	COG0126@1|root,COG0126@2|Bacteria,3Y2T7@57723|Acidobacteria,2JI0Z@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
CMS2_k127_5417515_16	760568.Desku_3293	7.933e-77	266.0	COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,260CH@186807|Peptococcaceae	186801|Clostridia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
CMS2_k127_5417515_35	234267.Acid_6765	6.108e-24	106.0	COG1314@1|root,COG1314@2|Bacteria,3Y56S@57723|Acidobacteria	57723|Acidobacteria	U	Preprotein translocase SecG subunit	-	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
CMS2_k127_5417515_14	1265505.ATUG01000001_gene4767	4.162e-89	302.0	COG0583@1|root,COG0583@2|Bacteria,1PHGE@1224|Proteobacteria,43EXR@68525|delta/epsilon subdivisions,2X2S8@28221|Deltaproteobacteria,2MP9V@213118|Desulfobacterales	28221|Deltaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
CMS2_k127_5417515_21	1047013.AQSP01000084_gene768	1.447e-68	243.0	COG1801@1|root,COG1801@2|Bacteria,2NPDU@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
CMS2_k127_5417515_36	436114.SYO3AOP1_0254	8.665e-22	100.0	COG0319@1|root,COG0319@2|Bacteria,2G5AR@200783|Aquificae	200783|Aquificae	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
CMS2_k127_5417515_11	1047013.AQSP01000057_gene1928	1.81e-112	392.0	COG1480@1|root,COG1480@2|Bacteria,2NP1K@2323|unclassified Bacteria	2|Bacteria	S	7TM receptor with intracellular HD hydrolase	yqfF	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
CMS2_k127_5417515_15	608506.COB47_1285	6.951e-81	280.0	COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia,42EZD@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM PhoH family protein	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
CMS2_k127_5417515_23	869213.JCM21142_104535	4.327e-64	229.0	COG1641@1|root,COG1641@2|Bacteria,4P2G5@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function DUF111	-	-	-	-	-	-	-	-	-	-	-	-	DUF111
CMS2_k127_5417515_13	1293054.HSACCH_01488	2.273e-90	307.0	COG0846@1|root,COG0846@2|Bacteria,1TQKD@1239|Firmicutes,2491J@186801|Clostridia,3WBW4@53433|Halanaerobiales	186801|Clostridia	K	PFAM Silent information regulator protein Sir2	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
CMS2_k127_5417515_9	1121104.AQXH01000004_gene55	1.262e-127	421.0	COG1914@1|root,COG1914@2|Bacteria,4NEG8@976|Bacteroidetes	976|Bacteroidetes	P	Mn2 and Fe2 transporters of the NRAMP family	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
CMS2_k127_5417515_2	56780.SYN_02378	4.598e-296	926.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2WJ2W@28221|Deltaproteobacteria,2MQYS@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	C-terminal, D2-small domain, of ClpB protein	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
CMS2_k127_5417515_31	56780.SYN_02377	1.645e-33	132.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2WQ23@28221|Deltaproteobacteria,2MS9E@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
CMS2_k127_5417515_17	768670.Calni_1910	1.441e-72	256.0	COG2378@1|root,COG2378@2|Bacteria	2|Bacteria	K	regulation of single-species biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
CMS2_k127_5417515_40	1313301.AUGC01000006_gene118	1.66e-14	78.0	2DMN0@1|root,32SKB@2|Bacteria,4NVJ6@976|Bacteroidetes	976|Bacteroidetes	S	HIRAN domain	-	-	-	-	-	-	-	-	-	-	-	-	HIRAN
CMS2_k127_5417515_18	398767.Glov_2167	1.472e-72	252.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,42M4J@68525|delta/epsilon subdivisions,2WJM8@28221|Deltaproteobacteria,43T7P@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM ABC transporter related	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
CMS2_k127_5417515_37	1167006.UWK_00098	3.752e-18	100.0	COG1639@1|root,COG2199@1|root,COG1639@2|Bacteria,COG3706@2|Bacteria,1MVRF@1224|Proteobacteria,42USR@68525|delta/epsilon subdivisions,2WR2D@28221|Deltaproteobacteria,2MK3C@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HDOD
CMS2_k127_5417515_34	880073.Calab_2681	2.493e-26	127.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
CMS2_k127_5417515_0	639282.DEFDS_0235	0.0	1133.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GF76@200930|Deferribacteres	200930|Deferribacteres	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS2_k127_5417515_12	1047013.AQSP01000066_gene722	1.477e-92	313.0	COG1131@1|root,COG1131@2|Bacteria,2NQTK@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	pilH	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_5417515_27	1047013.AQSP01000066_gene721	1.042e-53	198.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	pilI	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
CMS2_k127_5417515_24	1047013.AQSP01000066_gene719	9.299e-62	222.0	COG1989@1|root,COG1989@2|Bacteria,2NPDS@2323|unclassified Bacteria	2|Bacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02236,ko:K02278,ko:K02506,ko:K02654,ko:K10966	-	M00331,M00429	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
CMS2_k127_5417515_32	96561.Dole_0426	3.093e-30	135.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,2MHU3@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,sCache_3_2
CMS2_k127_5417515_4	1123008.KB905703_gene558	4.922e-176	557.0	COG1063@1|root,COG1063@2|Bacteria,4NHCK@976|Bacteroidetes,2G2S2@200643|Bacteroidia,231Y9@171551|Porphyromonadaceae	976|Bacteroidetes	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS2_k127_5417515_44	5762.XP_002681516.1	2.856e-06	59.0	COG5184@1|root,KOG1426@2759|Eukaryota	2759|Eukaryota	DZ	guanyl-nucleotide exchange factor activity	-	-	-	-	-	-	-	-	-	-	-	-	RCC1
CMS2_k127_5417515_48	1122986.KB908323_gene889	0.0008851	55.0	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,2FM2N@200643|Bacteroidia	976|Bacteroidetes	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_5417515_42	234267.Acid_6081	3.139e-12	83.0	COG3292@1|root,COG3292@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,HATPase_c,PKD_3,Reg_prop
CMS2_k127_5436076_4	1236514.BAKL01000015_gene1639	6.973e-07	59.0	COG1475@1|root,COG1475@2|Bacteria,4P1X3@976|Bacteroidetes,2FRXC@200643|Bacteroidia,4AW85@815|Bacteroidaceae	976|Bacteroidetes	K	ParB-like nuclease domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4417,ParBc
CMS2_k127_5436076_1	1236514.BAKL01000015_gene1638	1.809e-23	109.0	28KSZ@1|root,2ZAA8@2|Bacteria,4NHC3@976|Bacteroidetes,2FVKP@200643|Bacteroidia,4ASWA@815|Bacteroidaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5436076_5	398720.MED217_17195	1.984e-05	53.0	28UNP@1|root,2ZGT6@2|Bacteria,4P8YC@976|Bacteroidetes,1IB9X@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5436076_2	406124.ACPC01000049_gene114	1.451e-15	79.0	2C5U6@1|root,330NX@2|Bacteria,1VGSI@1239|Firmicutes,4IM3A@91061|Bacilli,1ZIZM@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5436076_0	755731.Clo1100_0605	0.0	1275.0	COG0210@1|root,COG0514@1|root,COG0210@2|Bacteria,COG0514@2|Bacteria,1TPN5@1239|Firmicutes,247ZA@186801|Clostridia,36DC9@31979|Clostridiaceae	186801|Clostridia	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind,UvrD_C
CMS2_k127_5436076_3	111781.Lepto7376_0368	1.619e-10	74.0	COG1345@1|root,COG1345@2|Bacteria	2|Bacteria	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	GO:0001539,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
CMS2_k127_5499956_3	240292.Ava_2971	5.795e-180	606.0	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1HKN5@1161|Nostocales	1117|Cyanobacteria	S	PFAM WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35,WD40
CMS2_k127_5499956_18	631362.Thi970DRAFT_00609	4.733e-49	202.0	COG1672@1|root,COG1672@2|Bacteria,1QVZA@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator, CadC	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_35,TPR_10,Trans_reg_C
CMS2_k127_5499956_29	272134.KB731324_gene3229	1.76e-07	64.0	COG5002@1|root,COG5002@2|Bacteria,1GQDS@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS2_k127_5499956_31	673860.AciM339_0928	7.733e-05	56.0	COG0642@1|root,COG2202@1|root,arCOG02349@1|root,arCOG02350@1|root,arCOG02360@1|root,arCOG02367@1|root,arCOG02334@2157|Archaea,arCOG02349@2157|Archaea,arCOG02350@2157|Archaea,arCOG02360@2157|Archaea,arCOG02367@2157|Archaea,arCOG06408@2157|Archaea,arCOG06918@2157|Archaea,2Y6CZ@28890|Euryarchaeota,3F36F@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_9
CMS2_k127_5499956_26	502025.Hoch_3340	3.121e-17	96.0	COG0642@1|root,COG0642@2|Bacteria	2|Bacteria	T	Histidine kinase	cvnA1	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,NIT,PAS,PAS_9,Response_reg
CMS2_k127_5499956_33	1034943.BN1094_02790	0.0009311	52.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1JC4N@118969|Legionellales	1236|Gammaproteobacteria	T	sensory box histidine kinase response regulator	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg
CMS2_k127_5499956_30	1047013.AQSP01000068_gene2281	6.65e-06	59.0	28WP9@1|root,2ZINZ@2|Bacteria	1047013.AQSP01000068_gene2281|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5499956_28	391612.CY0110_22597	4.834e-08	61.0	COG1988@1|root,COG1988@2|Bacteria,1G9P5@1117|Cyanobacteria,3KJG1@43988|Cyanothece	1117|Cyanobacteria	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
CMS2_k127_5499956_13	880073.Calab_3437	2.706e-80	285.0	COG1600@1|root,COG1600@2|Bacteria,2NQCR@2323|unclassified Bacteria	2|Bacteria	C	Reductive dehalogenase subunit	cprA	-	-	-	-	-	-	-	-	-	-	-	Dehalogenase,Fer4,Fer4_7
CMS2_k127_5499956_1	313606.M23134_00483	5.045e-199	629.0	COG0076@1|root,COG0076@2|Bacteria,4NFUP@976|Bacteroidetes,47MZ0@768503|Cytophagia	976|Bacteroidetes	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
CMS2_k127_5499956_9	177437.HRM2_29080	1.741e-108	367.0	COG0446@1|root,COG1251@1|root,COG0446@2|Bacteria,COG1251@2|Bacteria,1MXA9@1224|Proteobacteria,42TSQ@68525|delta/epsilon subdivisions,2WQZT@28221|Deltaproteobacteria,2MK7P@213118|Desulfobacterales	28221|Deltaproteobacteria	C	BFD-like [2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD,Pyr_redox_2
CMS2_k127_5499956_25	177437.HRM2_29070	4.349e-21	95.0	COG1034@1|root,COG1034@2|Bacteria,1N72X@1224|Proteobacteria,43BTK@68525|delta/epsilon subdivisions,2X74H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4
CMS2_k127_5499956_21	1047013.AQSP01000123_gene1526	1.558e-43	171.0	COG4219@1|root,COG4219@2|Bacteria,2NR11@2323|unclassified Bacteria	2|Bacteria	KT	Peptidase M56	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	DUF4367,TonB_C
CMS2_k127_5499956_20	1047013.AQSP01000123_gene1526	1.13e-45	177.0	COG4219@1|root,COG4219@2|Bacteria,2NR11@2323|unclassified Bacteria	2|Bacteria	KT	Peptidase M56	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	DUF4367,TonB_C
CMS2_k127_5499956_11	1047013.AQSP01000123_gene1525	3.02e-105	372.0	COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria,2NPK1@2323|unclassified Bacteria	2|Bacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
CMS2_k127_5499956_7	1047013.AQSP01000123_gene1523	2.279e-124	434.0	COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria	2|Bacteria	P	COGs COG1629 Outer membrane receptor protein mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
CMS2_k127_5499956_0	1047013.AQSP01000123_gene1533	3.295e-222	711.0	COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
CMS2_k127_5499956_17	1047013.AQSP01000123_gene1524	1.002e-52	199.0	COG0457@1|root,COG0457@2|Bacteria	1047013.AQSP01000123_gene1524|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5499956_5	1047013.AQSP01000123_gene1527	2.417e-159	526.0	COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,2NR7I@2323|unclassified Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
CMS2_k127_5499956_27	1047013.AQSP01000144_gene827	4.503e-14	85.0	COG1807@1|root,COG1807@2|Bacteria,2NS0B@2323|unclassified Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS2_k127_5499956_2	204536.SULAZ_0357	1.718e-193	621.0	COG1086@1|root,COG1086@2|Bacteria,2G54P@200783|Aquificae	200783|Aquificae	M	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_2
CMS2_k127_5499956_8	768704.Desmer_4119	2.794e-116	387.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,26147@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	-	-	1.17.1.1,2.6.1.102	ko:K12452,ko:K13010	ko00520,map00520	-	R03391,R03392,R10460	RC00006,RC00230,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_5499956_19	1499967.BAYZ01000066_gene6060	4.377e-48	180.0	COG0110@1|root,COG0110@2|Bacteria,2NPWU@2323|unclassified Bacteria	2|Bacteria	GM	Bacterial transferase hexapeptide (six repeats)	-	-	-	ko:K19429	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,NAD_binding_9
CMS2_k127_5499956_14	1415775.U729_538	1.085e-77	266.0	COG2148@1|root,COG2148@2|Bacteria,1TP49@1239|Firmicutes,249F1@186801|Clostridia,36DJ2@31979|Clostridiaceae	186801|Clostridia	M	Bacterial sugar transferase	epsL	-	-	ko:K13012	-	-	-	-	ko00000,ko01005	-	-	-	Bac_transf
CMS2_k127_5499956_22	32057.KB217478_gene3928	7.588e-41	158.0	COG0110@1|root,COG0110@2|Bacteria,1G86N@1117|Cyanobacteria,1HPAJ@1161|Nostocales	1117|Cyanobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
CMS2_k127_5499956_10	515635.Dtur_0585	5.211e-107	361.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	wlbE	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_5499956_12	477974.Daud_1698	1.87e-98	333.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,26147@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_5499956_15	156889.Mmc1_2423	7.654e-68	233.0	COG0110@1|root,COG0110@2|Bacteria,1RDCP@1224|Proteobacteria,2TWW2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
CMS2_k127_5499956_6	1036674.A28LD_1628	1.117e-153	493.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,1S1E3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	oxidoreductase	wblB	-	1.1.1.335	ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_5499956_4	370438.PTH_1420	2.434e-167	536.0	COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,2484D@186801|Clostridia,2614W@186807|Peptococcaceae	186801|Clostridia	J	class II (D K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
CMS2_k127_5504637_63	331678.Cphamn1_2133	4.983e-24	107.0	COG3206@1|root,COG3206@2|Bacteria,1FEGE@1090|Chlorobi	1090|Chlorobi	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
CMS2_k127_5504637_77	933262.AXAM01000049_gene3277	3.863e-07	57.0	COG1672@1|root,COG1672@2|Bacteria,1NVKW@1224|Proteobacteria,42ZXT@68525|delta/epsilon subdivisions,2WVI1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ATPase domain predominantly from Archaea	-	-	-	-	-	-	-	-	-	-	-	-	ATPase_2
CMS2_k127_5504637_57	1304885.AUEY01000070_gene1843	3.234e-32	126.0	2CT64@1|root,32SSN@2|Bacteria,1N7H4@1224|Proteobacteria,42WK1@68525|delta/epsilon subdivisions,2WRS4@28221|Deltaproteobacteria,2MM5U@213118|Desulfobacterales	28221|Deltaproteobacteria	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
CMS2_k127_5504637_51	290317.Cpha266_2191	3.381e-39	150.0	COG4226@1|root,COG4226@2|Bacteria	2|Bacteria	K	protein encoded in hypervariable junctions of pilus gene clusters	-	-	-	-	-	-	-	-	-	-	-	-	HicB
CMS2_k127_5504637_75	1289135.A966_09967	2.713e-08	57.0	COG5464@1|root,COG5464@2|Bacteria,2J6UB@203691|Spirochaetes	203691|Spirochaetes	S	hmm tigr01784	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_5504637_36	522772.Dacet_2314	4.38e-63	237.0	COG1766@1|root,COG1766@2|Bacteria,2GETK@200930|Deferribacteres	200930|Deferribacteres	N	The M ring may be actively involved in energy transduction	-	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
CMS2_k127_5504637_15	903818.KI912268_gene1678	8.135e-133	431.0	COG1536@1|root,COG1536@2|Bacteria,3Y2U7@57723|Acidobacteria	57723|Acidobacteria	N	flagellar motor switch protein FliG	-	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
CMS2_k127_5504637_78	161156.JQKW01000012_gene89	1.22e-06	57.0	COG1317@1|root,COG1317@2|Bacteria,2GHI3@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	NU	Flagellar assembly protein FliH	-	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
CMS2_k127_5504637_50	1499684.CCNP01000025_gene3514	2.211e-40	155.0	COG5017@1|root,COG5017@2|Bacteria,1VCGX@1239|Firmicutes,25CFS@186801|Clostridia,36WVB@31979|Clostridiaceae	186801|Clostridia	S	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
CMS2_k127_5504637_37	632518.Calow_1962	1.23e-60	213.0	COG0707@1|root,COG0707@2|Bacteria,1V57Q@1239|Firmicutes,25BC8@186801|Clostridia	186801|Clostridia	M	Oligosaccharide biosynthesis protein Alg14 like	-	-	-	-	-	-	-	-	-	-	-	-	Alg14
CMS2_k127_5504637_31	306281.AJLK01000153_gene2141	4.879e-74	263.0	COG0438@1|root,COG0438@2|Bacteria,1G1X1@1117|Cyanobacteria,1JGSU@1189|Stigonemataceae	1117|Cyanobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_5504637_41	1499967.BAYZ01000009_gene5269	7.558e-55	206.0	COG0472@1|root,COG0472@2|Bacteria,2NPJ8@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase family 4	tagO	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
CMS2_k127_5504637_30	697303.Thewi_0779	9.425e-77	268.0	COG1216@1|root,COG1216@2|Bacteria,1UYRR@1239|Firmicutes,24BJN@186801|Clostridia	186801|Clostridia	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
CMS2_k127_5504637_25	435590.BVU_1728	7.083e-82	286.0	COG0438@1|root,COG0438@2|Bacteria,4NETA@976|Bacteroidetes,2FQ0S@200643|Bacteroidia,4AP64@815|Bacteroidaceae	976|Bacteroidetes	M	Glycosyltransferase, group 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_5504637_32	266117.Rxyl_0564	8.555e-74	259.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	2.4.1.349	ko:K07011,ko:K12994	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_tranf_2_3,Glycos_transf_2
CMS2_k127_5504637_27	439235.Dalk_0237	1.084e-80	301.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_5504637_18	573370.DMR_35990	1.829e-117	413.0	COG1404@1|root,COG1404@2|Bacteria,1RC5K@1224|Proteobacteria,42U2I@68525|delta/epsilon subdivisions,2WQAT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS2_k127_5504637_68	243231.GSU1698	1.459e-18	102.0	COG0457@1|root,COG0457@2|Bacteria,1NSRW@1224|Proteobacteria,42YBG@68525|delta/epsilon subdivisions,2WTZ6@28221|Deltaproteobacteria,43TDF@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
CMS2_k127_5504637_61	1278073.MYSTI_06352	2.654e-27	131.0	COG0457@1|root,COG0457@2|Bacteria,1R7RK@1224|Proteobacteria,42PPY@68525|delta/epsilon subdivisions,2WKX6@28221|Deltaproteobacteria,2YUCP@29|Myxococcales	28221|Deltaproteobacteria	NU	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19
CMS2_k127_5504637_45	351627.Csac_2151	3.747e-47	176.0	COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,248IT@186801|Clostridia,42FWD@68295|Thermoanaerobacterales	186801|Clostridia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
CMS2_k127_5504637_56	1125863.JAFN01000001_gene2291	2.268e-32	132.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,42TMU@68525|delta/epsilon subdivisions,2WQ67@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
CMS2_k127_5504637_19	1047013.AQSP01000099_gene1497	1.467e-114	386.0	COG0793@1|root,COG0793@2|Bacteria,2NNVZ@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
CMS2_k127_5504637_80	1322246.BN4_12552	0.0001834	50.0	2AKQ6@1|root,2ZAYQ@2|Bacteria,1R429@1224|Proteobacteria,42NWN@68525|delta/epsilon subdivisions,2WMKI@28221|Deltaproteobacteria,2MHI2@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3426)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3426,zinc_ribbon_4,zinc_ribbon_5
CMS2_k127_5504637_72	645991.Sgly_2339	1.638e-09	65.0	COG1716@1|root,COG1716@2|Bacteria,1V5U0@1239|Firmicutes,24IDE@186801|Clostridia,261TT@186807|Peptococcaceae	186801|Clostridia	T	(FHA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,Yop-YscD_cpl
CMS2_k127_5504637_42	1047013.AQSP01000028_gene2076	4.358e-49	195.0	COG3379@1|root,COG3379@2|Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest,Sulfotransfer_1,TPR_16,TPR_19
CMS2_k127_5504637_28	941824.TCEL_00138	2.945e-78	269.0	COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,36DHC@31979|Clostridiaceae	186801|Clostridia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
CMS2_k127_5504637_52	56110.Oscil6304_5612	1.943e-38	157.0	2E53X@1|root,32ZWX@2|Bacteria,1GQBK@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5504637_14	1244531.CIG1485E_0946	2.16e-133	441.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,42MIR@68525|delta/epsilon subdivisions,2YN3N@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Alginate O-acetylation protein	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
CMS2_k127_5504637_1	313606.M23134_05475	0.0	2004.0	COG2373@1|root,COG2373@2|Bacteria,4NED2@976|Bacteroidetes,47MEM@768503|Cytophagia	976|Bacteroidetes	S	Alpha-2-macroglobulin family	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,CarbopepD_reg_2,Plug
CMS2_k127_5504637_22	1122614.JHZF01000011_gene1160	6.416e-86	304.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2PCF3@252301|Oceanicola	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
CMS2_k127_5504637_35	871968.DESME_03105	3.059e-63	226.0	COG0351@1|root,COG0351@2|Bacteria,1TQ4A@1239|Firmicutes,2483H@186801|Clostridia,260UU@186807|Peptococcaceae	186801|Clostridia	H	TIGRFAM phosphomethylpyrimidine kinase	thiD	-	2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7	ko:K00868,ko:K00941,ko:K14153	ko00730,ko00750,ko01100,map00730,map00750,map01100	M00127	R00174,R01909,R02493,R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
CMS2_k127_5504637_40	880070.Cycma_4195	2.317e-56	205.0	COG2834@1|root,COG2834@2|Bacteria,4NIT5@976|Bacteroidetes,47SW9@768503|Cytophagia	976|Bacteroidetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS2_k127_5504637_43	926692.AZYG01000054_gene2289	1.1e-48	191.0	COG4591@1|root,COG4591@2|Bacteria,1USMZ@1239|Firmicutes,25ANE@186801|Clostridia,3WBES@53433|Halanaerobiales	186801|Clostridia	M	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_5504637_39	1293054.HSACCH_01703	1.36e-58	219.0	COG4591@1|root,COG4591@2|Bacteria,1TQ8J@1239|Firmicutes,24BJ2@186801|Clostridia,3WAFT@53433|Halanaerobiales	186801|Clostridia	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_5504637_24	748449.Halha_0932	1.528e-82	280.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,3WB27@53433|Halanaerobiales	186801|Clostridia	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_5504637_58	1047013.AQSP01000121_gene2715	3.785e-32	139.0	2C2F5@1|root,32WND@2|Bacteria,2NQ6T@2323|unclassified Bacteria	2|Bacteria	-	-	VPA0561	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5504637_48	926550.CLDAP_36940	8.691e-44	170.0	COG1309@1|root,COG1309@2|Bacteria,2G76J@200795|Chloroflexi	200795|Chloroflexi	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS2_k127_5504637_67	1500894.JQNN01000001_gene4377	1.378e-18	89.0	COG0662@1|root,COG0662@2|Bacteria,1RHWU@1224|Proteobacteria,2VT6E@28216|Betaproteobacteria,477IP@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Protein of unknown function (DUF861)	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS2_k127_5504637_17	909663.KI867150_gene970	2.109e-118	400.0	COG4191@1|root,COG4191@2|Bacteria,1R89N@1224|Proteobacteria,42QDX@68525|delta/epsilon subdivisions,2WKNA@28221|Deltaproteobacteria,2MR83@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS
CMS2_k127_5504637_10	909663.KI867150_gene971	7.813e-184	584.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2X1VS@28221|Deltaproteobacteria,2MRES@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_5504637_71	335543.Sfum_2441	8.335e-11	66.0	299YV@1|root,2ZX0J@2|Bacteria,1P75H@1224|Proteobacteria,432SS@68525|delta/epsilon subdivisions,2WY0Q@28221|Deltaproteobacteria,2MSEU@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5504637_47	1047013.AQSP01000091_gene641	2.144e-44	173.0	COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS2_k127_5504637_2	1047013.AQSP01000091_gene642	0.0	1178.0	COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	sfrB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0055114,GO:0071944	1.12.1.3,1.17.1.10,1.6.5.3	ko:K00335,ko:K15022,ko:K18331	ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00134,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
CMS2_k127_5504637_23	1047013.AQSP01000091_gene643	4.896e-85	287.0	COG3383@1|root,COG3383@2|Bacteria,2NNXH@2323|unclassified Bacteria	2|Bacteria	C	Iron hydrogenase small subunit	-	-	1.12.1.3,1.17.1.9,1.6.5.3	ko:K00123,ko:K00336,ko:K18332	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iHN637.CLJU_RS03470	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_21,Fer4_7,NADH-G_4Fe-4S_3
CMS2_k127_5504637_6	1047013.AQSP01000091_gene644	3.821e-248	775.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	yahG	-	-	-	-	-	-	-	-	-	-	-	DUF1116,FMN_dh,Glu_synthase
CMS2_k127_5504637_38	436114.SYO3AOP1_0232	1.28e-60	225.0	COG2265@1|root,COG2265@2|Bacteria,2G3V7@200783|Aquificae	200783|Aquificae	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	tRNA_U5-meth_tr
CMS2_k127_5504637_60	517418.Ctha_1486	2.284e-27	126.0	2EEYB@1|root,338RQ@2|Bacteria,1FF1Q@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5504637_69	452637.Oter_2199	2.821e-12	81.0	COG0457@1|root,COG0457@2|Bacteria,46W4N@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5504637_34	391623.TERMP_00031	4.256e-64	228.0	COG1122@1|root,arCOG00202@2157|Archaea,2XT28@28890|Euryarchaeota,243EW@183968|Thermococci	183968|Thermococci	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
CMS2_k127_5504637_33	1047013.AQSP01000033_gene1389	2.01e-71	249.0	COG0639@1|root,COG0639@2|Bacteria,2NPHT@2323|unclassified Bacteria	2|Bacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
CMS2_k127_5504637_70	204669.Acid345_2692	3.789e-12	78.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5504637_59	880073.Calab_0469	3.861e-28	132.0	COG0741@1|root,COG0741@2|Bacteria,2NPKN@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase SLT domain	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_16,TPR_6
CMS2_k127_5504637_20	1047013.AQSP01000132_gene1740	7.762e-91	311.0	COG1181@1|root,COG1181@2|Bacteria,2NPB2@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4,6.3.2.8	ko:K01921,ko:K01924	ko00471,ko00473,ko00550,ko01100,ko01502,map00471,map00473,map00550,map01100,map01502	-	R01150,R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N,Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS2_k127_5504637_66	1291050.JAGE01000001_gene2643	9.924e-19	91.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,3WJ8E@541000|Ruminococcaceae	186801|Clostridia	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
CMS2_k127_5504637_26	1047013.AQSP01000132_gene1738	2.773e-81	283.0	COG1559@1|root,COG1559@2|Bacteria,2NP75@2323|unclassified Bacteria	2|Bacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
CMS2_k127_5504637_76	1195236.CTER_0969	8.392e-08	61.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia	186801|Clostridia	T	response regulator receiver	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
CMS2_k127_5504637_13	880073.Calab_2889	3.029e-138	467.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2NQIQ@2323|unclassified Bacteria	2|Bacteria	E	X-Pro dipeptidyl-peptidase (S15 family)	dpp	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
CMS2_k127_5504637_11	439235.Dalk_2094	1.029e-159	530.0	COG0664@1|root,COG1752@1|root,COG0664@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,42RSN@68525|delta/epsilon subdivisions,2WNDI@28221|Deltaproteobacteria,2MPUY@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin,cNMP_binding
CMS2_k127_5504637_74	504472.Slin_4640	1.718e-08	59.0	2E1JK@1|root,32WX8@2|Bacteria,4NTME@976|Bacteroidetes,47RMM@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5504637_8	1047013.AQSP01000142_gene184	1.22e-208	675.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_5504637_49	986075.CathTA2_2880	1.173e-43	174.0	COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,4HH1E@91061|Bacilli	91061|Bacilli	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
CMS2_k127_5504637_44	1304885.AUEY01000013_gene3100	2.152e-47	185.0	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,42T3V@68525|delta/epsilon subdivisions,2WPYF@28221|Deltaproteobacteria,2MKDN@213118|Desulfobacterales	28221|Deltaproteobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS2_k127_5504637_21	877455.Metbo_0536	4.104e-90	303.0	COG1635@1|root,arCOG00574@2157|Archaea,2XTXH@28890|Euryarchaeota,23PFD@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur	thi4	-	-	ko:K03146	ko00730,ko01100,map00730,map01100	-	R10685	RC00033,RC03253,RC03254	ko00000,ko00001	-	-	-	Thi4
CMS2_k127_5504637_3	1047013.AQSP01000125_gene2642	2.777e-268	842.0	COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria	2|Bacteria	J	elongation factor G	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS2_k127_5504637_62	1267533.KB906741_gene608	2.791e-27	115.0	2DTIS@1|root,33KJ1@2|Bacteria,3Y5U4@57723|Acidobacteria,2JN6V@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5504637_16	391623.TERMP_01299	1.181e-121	403.0	COG1167@1|root,arCOG00492@2157|Archaea,2XVD6@28890|Euryarchaeota,243KU@183968|Thermococci	183968|Thermococci	K	Alanine-glyoxylate amino-transferase	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
CMS2_k127_5504637_5	880073.Calab_3076	7.9e-251	810.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2NNKC@2323|unclassified Bacteria	2|Bacteria	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,PDZ,PDZ_2,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
CMS2_k127_5504637_53	1379698.RBG1_1C00001G0320	5.582e-35	143.0	COG0030@1|root,COG0030@2|Bacteria,2NPDT@2323|unclassified Bacteria	2|Bacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528,ko:K15256	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009,ko03016	-	-	-	Methyltransf_21,RrnaAD
CMS2_k127_5504637_29	1047013.AQSP01000099_gene1502	6.082e-78	276.0	COG0621@1|root,COG0621@2|Bacteria,2NP2U@2323|unclassified Bacteria	2|Bacteria	J	Uncharacterized protein family UPF0004	mtaB	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
CMS2_k127_5504637_46	1047013.AQSP01000099_gene1501	1.129e-46	173.0	COG0041@1|root,COG0041@2|Bacteria,2NPN4@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
CMS2_k127_5504637_12	868864.Dester_0424	1.087e-142	464.0	COG0151@1|root,COG0151@2|Bacteria,2G3J3@200783|Aquificae	200783|Aquificae	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
CMS2_k127_5504637_73	1370121.AUWS01000080_gene750	1.406e-08	63.0	28R8P@1|root,2ZDNC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5504637_54	368408.Tpen_1190	7.11e-34	139.0	arCOG10988@1|root,arCOG10988@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5504637_65	1120998.AUFC01000012_gene473	4.317e-21	106.0	COG0641@1|root,COG0641@2|Bacteria	2|Bacteria	C	radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS2_k127_5504637_55	1120934.KB894423_gene2776	4.31e-33	139.0	28M6Z@1|root,2ZAKH@2|Bacteria,2IA92@201174|Actinobacteria,4E1TU@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5504637_4	1237149.C900_05793	1.693e-253	818.0	COG1680@1|root,COG4615@1|root,COG1680@2|Bacteria,COG4615@2|Bacteria,4NJ17@976|Bacteroidetes	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,Beta-lactamase
CMS2_k127_5504637_0	1087481.AGFX01000012_gene3138	0.0	3134.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	fusAA	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_5504637_7	1501230.ET33_30840	2.296e-244	791.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Glyoxalase_4,Methyltransf_31,PP-binding,Thioesterase
CMS2_k127_5504637_9	574375.BAGA_06075	4.997e-200	649.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes	1239|Firmicutes	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_556295_2	660470.Theba_2561	3.273e-180	582.0	COG1307@1|root,COG1461@1|root,COG1307@2|Bacteria,COG1461@2|Bacteria,2GC94@200918|Thermotogae	2|Bacteria	S	DAK2 domain fusion protein YloV	yfhG	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2,DegV
CMS2_k127_556295_14	1196322.A370_03992	1.176e-25	114.0	2FG4I@1|root,34811@2|Bacteria,1W01I@1239|Firmicutes,24NTK@186801|Clostridia,36SB8@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_556295_7	1443122.Z958_12825	2.66e-72	252.0	COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,24AHV@186801|Clostridia,36G5G@31979|Clostridiaceae	186801|Clostridia	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	pucA	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
CMS2_k127_556295_12	1196322.A370_03993	3.549e-36	144.0	2DKP2@1|root,30A56@2|Bacteria,1W1S2@1239|Firmicutes,257IN@186801|Clostridia,36TX6@31979|Clostridiaceae	186801|Clostridia	S	NTPase	-	-	-	-	-	-	-	-	-	-	-	-	NTPase_1
CMS2_k127_556295_13	592015.HMPREF1705_01466	3.777e-26	115.0	COG0406@1|root,COG0406@2|Bacteria,3TB9I@508458|Synergistetes	508458|Synergistetes	G	phosphoglycerate mutase	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
CMS2_k127_556295_6	1499967.BAYZ01000139_gene153	8.931e-86	287.0	COG1418@1|root,COG1418@2|Bacteria,2NPXI@2323|unclassified Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950,ko:K09163	-	-	-	-	ko00000	-	-	-	HD
CMS2_k127_556295_15	1172188.KB911820_gene2577	1.877e-19	95.0	2FAXM@1|root,3434G@2|Bacteria,2IRD0@201174|Actinobacteria,4FHI7@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_556295_11	933262.AXAM01000172_gene934	3.072e-39	148.0	COG2337@1|root,COG2337@2|Bacteria,1N1DE@1224|Proteobacteria,42WAI@68525|delta/epsilon subdivisions,2WRAJ@28221|Deltaproteobacteria,2MNJZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
CMS2_k127_556295_9	706587.Desti_3526	5.809e-58	210.0	COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria,42TT9@68525|delta/epsilon subdivisions,2X6GK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Ergosterol biosynthesis ERG4/ERG24 family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_556295_0	1249627.D779_2279	7.331e-256	807.0	COG0624@1|root,COG1181@1|root,COG0624@2|Bacteria,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1WWYB@135613|Chromatiales	1236|Gammaproteobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477	Dala_Dala_lig_C,Dala_Dala_lig_N
CMS2_k127_556295_3	335543.Sfum_0989	4.119e-125	411.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,42MY5@68525|delta/epsilon subdivisions,2WKST@28221|Deltaproteobacteria,2MQY9@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
CMS2_k127_556295_8	335543.Sfum_0988	3.745e-68	236.0	COG0454@1|root,COG0456@2|Bacteria,1RF31@1224|Proteobacteria,42RUB@68525|delta/epsilon subdivisions,2WN97@28221|Deltaproteobacteria,2MS1U@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_556295_10	272123.Anacy_4407	8.135e-56	224.0	COG2931@1|root,COG5276@1|root,COG2931@2|Bacteria,COG5276@2|Bacteria,1GQ7S@1117|Cyanobacteria,1HRXM@1161|Nostocales	1117|Cyanobacteria	Q	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF4347,HemolysinCabind,LVIVD
CMS2_k127_556295_4	439235.Dalk_0237	1.491e-97	357.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_556295_1	1353529.M899_0960	6.657e-200	652.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,42MD4@68525|delta/epsilon subdivisions,2MSST@213481|Bdellovibrionales,2WJ7Z@28221|Deltaproteobacteria	213481|Bdellovibrionales	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
CMS2_k127_556295_5	639282.DEFDS_2021	2.961e-86	299.0	COG1373@1|root,COG1373@2|Bacteria,2GFZK@200930|Deferribacteres	200930|Deferribacteres	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_5570586_6	1047013.AQSP01000140_gene2461	1.469e-129	424.0	COG0438@1|root,COG0438@2|Bacteria,2NQED@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
CMS2_k127_5570586_5	696747.NIES39_A00310	9.071e-200	629.0	COG0615@1|root,COG2513@1|root,COG0615@2|Bacteria,COG2513@2|Bacteria,1G4G0@1117|Cyanobacteria,1HHEB@1150|Oscillatoriales	1117|Cyanobacteria	GM	Phosphoenolpyruvate phosphomutase	-	-	5.4.2.9	ko:K01841	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R00661	RC02792	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,NTP_transf_3,PEP_mutase
CMS2_k127_5570586_12	237368.SCABRO_00437	9.187e-14	82.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS2_k127_5570586_11	944480.ATUV01000002_gene132	1.379e-24	112.0	COG0558@1|root,COG1213@1|root,COG0558@2|Bacteria,COG1213@2|Bacteria,1NN43@1224|Proteobacteria,432HN@68525|delta/epsilon subdivisions,2WYCV@28221|Deltaproteobacteria,2M7MC@213113|Desulfurellales	28221|Deltaproteobacteria	IM	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
CMS2_k127_5570586_9	378806.STAUR_6512	2.004e-66	251.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,43AH9@68525|delta/epsilon subdivisions,2X5XB@28221|Deltaproteobacteria,2Z37F@29|Myxococcales	28221|Deltaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_5570586_10	351627.Csac_2708	7.682e-43	159.0	COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia,42GWD@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
CMS2_k127_5570586_7	509191.AEDB02000082_gene2581	8.201e-90	310.0	COG0037@1|root,COG0037@2|Bacteria,1V7J8@1239|Firmicutes,25Q2F@186801|Clostridia,3WQYS@541000|Ruminococcaceae	186801|Clostridia	D	tRNA processing	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5570586_1	1500893.JQNB01000001_gene2623	0.0	1345.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1X3AB@135614|Xanthomonadales	135614|Xanthomonadales	Q	non-ribosomal peptide synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_5570586_2	221288.JH992901_gene3915	5.878e-271	873.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1JI65@1189|Stigonemataceae	1117|Cyanobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,TPR_1,TPR_8,Thioesterase
CMS2_k127_5570586_8	449447.MAE_43100	1.005e-66	248.0	COG1262@1|root,COG4248@1|root,COG1262@2|Bacteria,COG4248@2|Bacteria,1G1D0@1117|Cyanobacteria	1117|Cyanobacteria	S	protein with protein kinase and helix-hairpin-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
CMS2_k127_5570586_4	1174528.JH992890_gene591	1.042e-204	658.0	COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria	2|Bacteria	O	carbamoyl transferase, NodU family	nolO	-	-	ko:K00612,ko:K16035	ko01051,ko01052,ko01130,map01051,map01052,map01130	-	R09853,R09858	RC00055,RC02840	ko00000,ko00001,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS2_k127_5570586_0	1009370.ALO_00935	0.0	1880.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_5570586_3	358681.BBR47_27890	4.489e-233	754.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5571545_0	755731.Clo1100_2632	0.0	1138.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_5615699_1	313606.M23134_08087	3.331e-233	743.0	COG1944@1|root,COG1944@2|Bacteria,4NKRG@976|Bacteroidetes	976|Bacteroidetes	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
CMS2_k127_5615699_5	313606.M23134_08085	2.809e-138	461.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_5615699_2	313606.M23134_08085	1.935e-152	501.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_5615699_4	313606.M23134_08085	2.512e-139	464.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_5615699_7	1047013.AQSP01000133_gene2133	2.588e-73	257.0	COG1995@1|root,COG1995@2|Bacteria,2NNWZ@2323|unclassified Bacteria	2|Bacteria	H	Pyridoxal phosphate biosynthetic protein PdxA	pdxA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050570,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.1.1.262,1.1.1.408,1.1.1.409,1.3.1.53	ko:K00097,ko:K18076,ko:K22024	ko00624,ko00750,ko01100,ko01120,ko01220,map00624,map00750,map01100,map01120,map01220	M00124,M00624	R01633,R05681,R05837,R07406	RC00089,RC00271,RC00675,RC01475	br01602,ko00000,ko00001,ko00002,ko01000	-	-	iECO111_1330.ECO111_0056	PdxA
CMS2_k127_5615699_23	1047013.AQSP01000133_gene2132	3.651e-24	106.0	COG1923@1|root,COG1923@2|Bacteria	2|Bacteria	S	positive regulation of translation, ncRNA-mediated	-	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
CMS2_k127_5615699_11	484019.THA_395	2.818e-57	214.0	COG1207@1|root,COG1207@2|Bacteria,2GBX0@200918|Thermotogae	200918|Thermotogae	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1629	Hexapep,NTP_transf_3,NTP_transferase
CMS2_k127_5615699_33	278963.ATWD01000002_gene607	2.172e-05	53.0	COG0457@1|root,COG0457@2|Bacteria,3Y4XQ@57723|Acidobacteria,2JJFK@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
CMS2_k127_5615699_19	1047013.AQSP01000071_gene1937	4.786e-34	135.0	COG0848@1|root,COG0848@2|Bacteria,2NPWJ@2323|unclassified Bacteria	2|Bacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
CMS2_k127_5615699_25	385682.AFSL01000069_gene1456	4.836e-21	101.0	COG1309@1|root,COG1309@2|Bacteria,4NIBT@976|Bacteroidetes,2FU2E@200643|Bacteroidia,3XKI9@558415|Marinilabiliaceae	976|Bacteroidetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS2_k127_5615699_32	483215.BACFIN_06550	7.226e-10	71.0	COG1538@1|root,COG1538@2|Bacteria,4NFSW@976|Bacteroidetes,2FNYU@200643|Bacteroidia,4AMFM@815|Bacteroidaceae	976|Bacteroidetes	MU	COG NOG26656 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_5615699_26	1379858.N508_01378	3.13e-20	102.0	COG0845@1|root,COG0845@2|Bacteria,2GFHR@200930|Deferribacteres	200930|Deferribacteres	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	HlyD_D23
CMS2_k127_5615699_13	1123009.AUID01000007_gene719	4.981e-56	207.0	COG1131@1|root,COG1131@2|Bacteria,1TQKM@1239|Firmicutes,25B35@186801|Clostridia,26ABF@186813|unclassified Clostridiales	186801|Clostridia	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS2_k127_5615699_9	880073.Calab_1304	1.087e-68	242.0	COG1131@1|root,COG1131@2|Bacteria,2NP0I@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	ybhF-C	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS2_k127_5615699_6	96561.Dole_0810	7.177e-78	274.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42P7V@68525|delta/epsilon subdivisions,2WJQA@28221|Deltaproteobacteria,2MJ2Q@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
CMS2_k127_5615699_8	96561.Dole_0811	3.794e-70	252.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42NC3@68525|delta/epsilon subdivisions,2WIJJ@28221|Deltaproteobacteria,2MJ98@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
CMS2_k127_5615699_12	1298880.AUEV01000010_gene2846	1.544e-56	205.0	COG4912@1|root,COG4912@2|Bacteria	2|Bacteria	L	Dna alkylation repair	alkD	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
CMS2_k127_5615699_34	411469.EUBHAL_02132	0.0004327	49.0	COG1595@1|root,COG1595@2|Bacteria,1VBJI@1239|Firmicutes,24NKR@186801|Clostridia,25WUQ@186806|Eubacteriaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_5615699_16	1121935.AQXX01000139_gene2978	4.897e-45	170.0	2BUWD@1|root,32Q8G@2|Bacteria,1RDE8@1224|Proteobacteria,1SQHJ@1236|Gammaproteobacteria,1XPUI@135619|Oceanospirillales	135619|Oceanospirillales	S	SatD family (SatD)	-	-	-	-	-	-	-	-	-	-	-	-	SatD
CMS2_k127_5615699_20	1121935.AQXX01000139_gene2979	6.712e-30	128.0	COG5061@1|root,COG5061@2|Bacteria,1RHE2@1224|Proteobacteria,1S6ZH@1236|Gammaproteobacteria,1XMVR@135619|Oceanospirillales	135619|Oceanospirillales	OU	Protein of unknown function (DUF3307)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3307
CMS2_k127_5615699_21	1047013.AQSP01000052_gene2596	1.437e-29	125.0	COG1595@1|root,COG1595@2|Bacteria,2NPR9@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_5615699_22	639282.DEFDS_1512	1.43e-28	124.0	COG0204@1|root,COG0204@2|Bacteria,2GFN3@200930|Deferribacteres	200930|Deferribacteres	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS2_k127_5615699_17	1216967.L100_13754	1.954e-44	175.0	COG0846@1|root,COG0846@2|Bacteria,4P1AS@976|Bacteroidetes	976|Bacteroidetes	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5615699_10	760568.Desku_2065	1.158e-62	232.0	2CKB7@1|root,32SC1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5615699_24	760568.Desku_2067	1.899e-22	104.0	COG3465@1|root,COG3465@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
CMS2_k127_5615699_15	1265505.ATUG01000002_gene1414	6.281e-46	177.0	COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,42RSB@68525|delta/epsilon subdivisions,2X6V6@28221|Deltaproteobacteria,2MMG6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
CMS2_k127_5615699_3	1047013.AQSP01000138_gene1020	3.158e-149	486.0	COG0008@1|root,COG0008@2|Bacteria,2NNMZ@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
CMS2_k127_5615699_14	546269.HMPREF0389_01072	1.286e-46	177.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia,25QG5@186804|Peptostreptococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
CMS2_k127_5615699_0	177437.HRM2_02020	6.808e-235	743.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42PUP@68525|delta/epsilon subdivisions,2WMAH@28221|Deltaproteobacteria,2MN7Y@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS2_k127_5623205_0	1408422.JHYF01000001_gene2794	0.0	1767.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5637021_0	1517682.HW49_00880	1.802e-31	126.0	COG0454@1|root,COG0456@2|Bacteria,4NFWE@976|Bacteroidetes,2FNG4@200643|Bacteroidia,22WRZ@171551|Porphyromonadaceae	976|Bacteroidetes	K	Psort location Cytoplasmic, score 8.96	yghO	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_5637021_1	489825.LYNGBM3L_42970	2.782e-17	83.0	COG3041@1|root,COG3041@2|Bacteria,1GFWR@1117|Cyanobacteria	1117|Cyanobacteria	S	Bacterial toxin of type II toxin-antitoxin system, YafQ	-	-	-	-	-	-	-	-	-	-	-	-	YafQ_toxin
CMS2_k127_5637021_2	525898.Sdel_1496	2.393e-15	78.0	COG3077@1|root,COG3077@2|Bacteria,1NGDT@1224|Proteobacteria,42WTT@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	RelB antitoxin	-	-	-	ko:K07473	-	-	-	-	ko00000,ko02048	-	-	-	RelB
CMS2_k127_5637021_3	1125779.HMPREF1219_02498	1.332e-11	71.0	COG1487@1|root,COG1487@2|Bacteria,2ID5E@201174|Actinobacteria,22PHW@1653|Corynebacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4411)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4411
CMS2_k127_5641296_1	1118054.CAGW01000113_gene3699	2.153e-94	317.0	COG4096@1|root,COG4096@2|Bacteria,1UI7V@1239|Firmicutes,4HD53@91061|Bacilli	91061|Bacilli	L	COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,HSDR_N_2,Helicase_C,ResIII
CMS2_k127_5641296_0	163908.KB235896_gene2024	4.246e-234	731.0	COG0286@1|root,COG0286@2|Bacteria,1G132@1117|Cyanobacteria,1HIFC@1161|Nostocales	1117|Cyanobacteria	V	HsdM N-terminal domain	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
CMS2_k127_5659074_1	582515.KR51_00010010	4.317e-72	265.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G2QK@1117|Cyanobacteria	1117|Cyanobacteria	T	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,CHAT,TPR_12,TPR_8
CMS2_k127_5659074_5	760568.Desku_2867	7.096e-22	100.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_5659074_2	118161.KB235922_gene4522	2.465e-39	147.0	COG4115@1|root,COG4115@2|Bacteria,1GJEN@1117|Cyanobacteria,3VN5J@52604|Pleurocapsales	1117|Cyanobacteria	S	YoeB-like toxin of bacterial type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	YoeB_toxin
CMS2_k127_5659074_3	1288826.MSNKSG1_06093	1.58e-27	114.0	COG2161@1|root,COG2161@2|Bacteria,1N6X6@1224|Proteobacteria,1SDQ0@1236|Gammaproteobacteria,4685U@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	yefM	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015643,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042710,GO:0043565,GO:0044010,GO:0044764,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051704,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
CMS2_k127_5659074_6	574376.BAMA_14845	1.772e-17	93.0	COG0491@1|root,COG0491@2|Bacteria,1V8JE@1239|Firmicutes,4HIYW@91061|Bacilli,1ZEQ1@1386|Bacillus	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_5659074_0	1125863.JAFN01000001_gene2887	3.584e-83	284.0	COG1600@1|root,COG1600@2|Bacteria,1MXS4@1224|Proteobacteria,431J8@68525|delta/epsilon subdivisions,2WWNQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5659074_4	1047013.AQSP01000128_gene439	2.812e-26	111.0	COG1504@1|root,COG1504@2|Bacteria,2NRWT@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
CMS2_k127_5666528_17	357808.RoseRS_3008	0.0009377	53.0	COG0739@1|root,COG2304@1|root,COG4412@1|root,COG0739@2|Bacteria,COG2304@2|Bacteria,COG4412@2|Bacteria,2GB3W@200795|Chloroflexi,377V9@32061|Chloroflexia	32061|Chloroflexia	E	PFAM von Willebrand factor type A	-	-	3.4.21.50	ko:K01337	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	VWA
CMS2_k127_5666528_1	1047013.AQSP01000135_gene1572	2.328e-200	656.0	COG0749@1|root,COG0749@2|Bacteria,2NNKA@2323|unclassified Bacteria	2|Bacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
CMS2_k127_5666528_15	1121920.AUAU01000025_gene2317	5.571e-16	81.0	2ET40@1|root,33KN7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5666528_12	1174528.JH992890_gene586	3.71e-31	125.0	COG3251@1|root,COG3251@2|Bacteria	2|Bacteria	P	PFAM MbtH domain protein	-	-	-	ko:K05375	ko00261,ko01130,map00261,map01130	M00736	R10880	RC00064,RC00141,RC03296,RC03297,RC03298	ko00000,ko00001,ko00002	-	-	-	CBF_beta,MbtH
CMS2_k127_5666528_4	1121405.dsmv_2139	2.788e-155	508.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42PJQ@68525|delta/epsilon subdivisions,2WKR4@28221|Deltaproteobacteria,2MIMH@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
CMS2_k127_5666528_11	1232437.KL662077_gene1933	1.827e-40	158.0	COG1762@1|root,COG1762@2|Bacteria,1RG0Z@1224|Proteobacteria,42RSF@68525|delta/epsilon subdivisions,2WNXB@28221|Deltaproteobacteria,2MJZ1@213118|Desulfobacterales	28221|Deltaproteobacteria	GT	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
CMS2_k127_5666528_0	880073.Calab_2811	9.34e-203	651.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,2NPC4@2323|unclassified Bacteria	2|Bacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	iAF987.Gmet_3470	CBS,TrkA_C,Voltage_CLC
CMS2_k127_5666528_5	795359.TOPB45_1516	8.854e-67	240.0	COG0482@1|root,COG0482@2|Bacteria,2GGVW@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
CMS2_k127_5666528_9	1047013.AQSP01000139_gene2417	2.932e-52	190.0	COG2078@1|root,COG2078@2|Bacteria,2NPQ0@2323|unclassified Bacteria	2|Bacteria	S	AMMECR1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
CMS2_k127_5666528_3	1347342.BN863_15680	1.926e-157	511.0	COG0471@1|root,COG0471@2|Bacteria,4NFDK@976|Bacteroidetes,1HX3U@117743|Flavobacteriia	976|Bacteroidetes	P	COG0471 Di- and tricarboxylate	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
CMS2_k127_5666528_10	1158345.JNLL01000001_gene1904	3.903e-49	188.0	COG1912@1|root,COG1912@2|Bacteria,2G44H@200783|Aquificae	200783|Aquificae	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
CMS2_k127_5666528_7	1384049.CD29_19160	4.612e-65	234.0	COG0491@1|root,COG0491@2|Bacteria,1TSU6@1239|Firmicutes,4HC5H@91061|Bacilli,3J05R@400634|Lysinibacillus	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_5666528_2	1296416.JACB01000013_gene4380	6.833e-173	549.0	COG0436@1|root,COG0436@2|Bacteria,4NSBB@976|Bacteroidetes,1IM6I@117743|Flavobacteriia,2YHQE@290174|Aquimarina	976|Bacteroidetes	E	Beta-eliminating lyase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS2_k127_5666528_6	1408473.JHXO01000003_gene2567	1.235e-66	240.0	COG0560@1|root,COG0560@2|Bacteria,4NIAJ@976|Bacteroidetes,2FQT9@200643|Bacteroidia	976|Bacteroidetes	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
CMS2_k127_5666528_16	240292.Ava_1354	9.657e-12	66.0	COG2405@1|root,COG2405@2|Bacteria,1G52J@1117|Cyanobacteria,1HPZ5@1161|Nostocales	1117|Cyanobacteria	S	Domain of unknown function (DUF3368)	-	-	-	ko:K07066	-	-	-	-	ko00000	-	-	-	DUF3368
CMS2_k127_5666528_13	246969.TAM4_767	2.057e-24	106.0	COG2405@1|root,arCOG00717@2157|Archaea,2Y6DU@28890|Euryarchaeota,2447P@183968|Thermococci	183968|Thermococci	V	Domain of unknown function (DUF3368)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3368
CMS2_k127_5666528_14	240292.Ava_1355	2.626e-22	98.0	COG2886@1|root,COG2886@2|Bacteria,1G7WF@1117|Cyanobacteria,1HSXH@1161|Nostocales	1117|Cyanobacteria	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
CMS2_k127_5666528_8	980584.AFPB01000163_gene2285	8.967e-60	213.0	COG2003@1|root,COG2003@2|Bacteria,4NP8R@976|Bacteroidetes,1I2NK@117743|Flavobacteriia	976|Bacteroidetes	L	RadC-like JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	RadC
CMS2_k127_5667731_3	1122947.FR7_3738	3.698e-32	128.0	COG0286@1|root,COG0286@2|Bacteria,1TPGZ@1239|Firmicutes,4H3U1@909932|Negativicutes	909932|Negativicutes	V	Type I restriction-modification system methyltransferase subunit	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
CMS2_k127_5667731_0	1177181.T9A_02135	5.466e-104	366.0	COG0732@1|root,COG0732@2|Bacteria,1MXVH@1224|Proteobacteria,1S29W@1236|Gammaproteobacteria,1XM02@135619|Oceanospirillales	135619|Oceanospirillales	V	restriction modification system DNA specificity	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
CMS2_k127_5667731_1	1111730.ATTM01000006_gene2560	2.538e-88	310.0	COG4637@1|root,COG4637@2|Bacteria,4PNSQ@976|Bacteroidetes,1IKB0@117743|Flavobacteriia	976|Bacteroidetes	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21
CMS2_k127_5667731_2	1111730.ATTM01000006_gene2561	1.134e-32	135.0	COG1403@1|root,COG1403@2|Bacteria,4NXRA@976|Bacteroidetes,1I5WD@117743|Flavobacteriia,2NWP6@237|Flavobacterium	976|Bacteroidetes	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5680283_38	1131269.AQVV01000012_gene2576	1.716e-34	138.0	COG4032@1|root,COG4032@2|Bacteria	2|Bacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	ppd	-	4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R04053	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
CMS2_k127_5680283_36	880072.Desac_2269	5.08e-39	152.0	COG0028@1|root,COG4032@1|root,COG0028@2|Bacteria,COG4032@2|Bacteria,1R6QP@1224|Proteobacteria,42Q6G@68525|delta/epsilon subdivisions,2WIXD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EH	PFAM thiamine pyrophosphate protein domain protein TPP-binding	-	-	4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R04053	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
CMS2_k127_5680283_22	880073.Calab_0837	9.469e-75	268.0	COG0534@1|root,COG0534@2|Bacteria,2NPBA@2323|unclassified Bacteria	2|Bacteria	V	MATE efflux family protein	mepA_10	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS2_k127_5680283_33	1121468.AUBR01000036_gene1308	1.689e-44	186.0	COG2203@1|root,COG3437@1|root,COG3605@1|root,COG4936@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG3605@2|Bacteria,COG4936@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia,42JGC@68295|Thermoanaerobacterales	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,PocR,SBP_bac_3
CMS2_k127_5680283_24	1167006.UWK_02787	4.553e-73	275.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria,2MJZM@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,PocR,Response_reg,SBP_bac_3,sCache_2
CMS2_k127_5680283_7	1121396.KB893079_gene859	3.79e-146	477.0	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42NMK@68525|delta/epsilon subdivisions,2WK6K@28221|Deltaproteobacteria,2MJD2@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_5680283_37	1121403.AUCV01000010_gene1368	1.049e-35	139.0	COG2204@1|root,COG2204@2|Bacteria,1QW8K@1224|Proteobacteria,42V8F@68525|delta/epsilon subdivisions,2WRMW@28221|Deltaproteobacteria,2MNUV@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_5680283_49	525897.Dbac_0418	3.491e-17	87.0	COG0745@1|root,COG0745@2|Bacteria,1N9SP@1224|Proteobacteria,43ECG@68525|delta/epsilon subdivisions,2X7Z1@28221|Deltaproteobacteria,2MHCQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_5680283_18	161156.JQKW01000007_gene682	1.647e-92	320.0	COG2204@1|root,COG2204@2|Bacteria,2GH1I@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_5680283_46	316067.Geob_3390	1.291e-18	98.0	COG3852@1|root,COG3852@2|Bacteria,1QUKH@1224|Proteobacteria,43BKB@68525|delta/epsilon subdivisions,2X6Y7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,sCache_3_2
CMS2_k127_5680283_41	1121403.AUCV01000051_gene2141	4.023e-24	115.0	COG0745@1|root,COG0745@2|Bacteria,1RIGT@1224|Proteobacteria,42SWP@68525|delta/epsilon subdivisions,2WPJ3@28221|Deltaproteobacteria,2MK4B@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,Response_reg
CMS2_k127_5680283_35	1313421.JHBV01000042_gene3320	4.74e-39	151.0	29IGX@1|root,305E4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5680283_23	1313421.JHBV01000042_gene3319	1.559e-73	252.0	29IGX@1|root,305E4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5680283_14	1123288.SOV_1c12760	4.031e-122	402.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4H2MX@909932|Negativicutes	909932|Negativicutes	E	cysteine desulfurase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS2_k127_5680283_53	1123075.AUDP01000019_gene1615	1.23e-11	68.0	2CH8H@1|root,2ZDM8@2|Bacteria,1W6P8@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5680283_43	517418.Ctha_2358	4.606e-23	111.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,GGDEF,Response_reg
CMS2_k127_5680283_34	1313421.JHBV01000042_gene3320	4.212e-41	157.0	29IGX@1|root,305E4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5680283_25	1313421.JHBV01000042_gene3319	3.523e-71	246.0	29IGX@1|root,305E4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5680283_0	385682.AFSL01000023_gene2163	0.0	1145.0	COG0188@1|root,COG0188@2|Bacteria,4NERI@976|Bacteroidetes,2FPAU@200643|Bacteroidia,3XJ07@558415|Marinilabiliaceae	976|Bacteroidetes	L	DNA Topoisomerase IV	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_topoisoIV
CMS2_k127_5680283_1	385682.AFSL01000023_gene2164	3.6e-291	905.0	COG0187@1|root,COG0187@2|Bacteria,4NF18@976|Bacteroidetes,2FMMD@200643|Bacteroidia,3XJF2@558415|Marinilabiliaceae	976|Bacteroidetes	L	TopoisomeraseII	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
CMS2_k127_5680283_15	237368.SCABRO_03313	1.796e-119	401.0	COG0469@1|root,COG0469@2|Bacteria,2IY60@203682|Planctomycetes	203682|Planctomycetes	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
CMS2_k127_5680283_55	350688.Clos_2838	0.0009013	48.0	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,24T3S@186801|Clostridia,36PB0@31979|Clostridiaceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19
CMS2_k127_5680283_45	1286171.EAL2_c08140	2.067e-19	103.0	COG0768@1|root,COG0768@2|Bacteria,1TPER@1239|Firmicutes,2486R@186801|Clostridia,25VFC@186806|Eubacteriaceae	186801|Clostridia	M	Penicillin-binding protein, transpeptidase domain protein	ftsI	-	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
CMS2_k127_5680283_32	161156.JQKW01000007_gene684	9.438e-46	173.0	COG0279@1|root,COG0279@2|Bacteria,2GGTJ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
CMS2_k127_5680283_2	945713.IALB_0301	2.366e-229	717.0	COG0334@1|root,COG0334@2|Bacteria	2|Bacteria	E	glutamate dehydrogenase [NAD(P)+] activity	gdhA	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS2_k127_5680283_44	880073.Calab_2608	6.446e-20	95.0	COG4191@1|root,COG4191@2|Bacteria	880073.Calab_2608|-	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5680283_3	1303518.CCALI_00158	1.061e-224	707.0	COG0166@1|root,COG0166@2|Bacteria	2|Bacteria	G	Belongs to the GPI family	pgi	GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0042221,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0070887,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iEcSMS35_1347.EcSMS35_4486	PGI
CMS2_k127_5680283_13	589865.DaAHT2_0019	2.995e-130	426.0	COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria,42NYF@68525|delta/epsilon subdivisions,2WIT2@28221|Deltaproteobacteria,2MI2C@213118|Desulfobacterales	28221|Deltaproteobacteria	C	radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS2_k127_5680283_4	177439.DP0087	8.758e-189	603.0	COG0318@1|root,COG0318@2|Bacteria,1QVGC@1224|Proteobacteria,43BUA@68525|delta/epsilon subdivisions	1224|Proteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding
CMS2_k127_5680283_54	589924.Ferp_2503	1.614e-08	65.0	COG0697@1|root,arCOG00271@2157|Archaea,2XXKE@28890|Euryarchaeota,2466R@183980|Archaeoglobi	183980|Archaeoglobi	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS2_k127_5680283_42	632335.Calkr_1772	4.514e-23	99.0	2E32K@1|root,32Y2U@2|Bacteria,1VFFP@1239|Firmicutes,24RID@186801|Clostridia,42IMC@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5680283_9	880073.Calab_0791	5.813e-144	473.0	COG2985@1|root,COG2985@2|Bacteria	2|Bacteria	S	potassium ion transport	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
CMS2_k127_5680283_39	926560.KE387023_gene2407	9.018e-29	121.0	COG1832@1|root,COG1832@2|Bacteria	2|Bacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
CMS2_k127_5680283_6	1385513.N780_08335	1.769e-147	481.0	COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,4HA18@91061|Bacilli	91061|Bacilli	C	Na H antiporter	-	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
CMS2_k127_5680283_29	1237149.C900_05552	1.063e-59	234.0	COG3227@1|root,COG3291@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,4NJK3@976|Bacteroidetes,47TYM@768503|Cytophagia	976|Bacteroidetes	E	Pregnancy-associated plasma protein-A	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_M43,fn3
CMS2_k127_5680283_8	502025.Hoch_1667	4.721e-144	488.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_5680283_21	1499967.BAYZ01000176_gene5632	1.82e-75	257.0	COG0693@1|root,COG0693@2|Bacteria,2NRMH@2323|unclassified Bacteria	2|Bacteria	S	DJ-1/PfpI family	thiJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006517,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009100,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019538,GO:0022613,GO:0030091,GO:0033554,GO:0034599,GO:0036211,GO:0036524,GO:0036525,GO:0042026,GO:0042221,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0071840,GO:0140096,GO:1901135,GO:1901564	2.7.11.1,3.5.1.124	ko:K03152,ko:K05520,ko:K05687,ko:K12132	ko05012,map05012	-	-	-	ko00000,ko00001,ko01000,ko01001,ko01002,ko04147	-	-	-	DJ-1_PfpI
CMS2_k127_5680283_16	748727.CLJU_c19440	1.187e-113	374.0	COG1533@1|root,COG1533@2|Bacteria,1TQA6@1239|Firmicutes,24A2T@186801|Clostridia,36FE2@31979|Clostridiaceae	186801|Clostridia	L	Domain of unknown function (DUF1848)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1848
CMS2_k127_5680283_26	580340.Tlie_1594	1.176e-65	234.0	COG2199@1|root,COG3829@1|root,COG3706@2|Bacteria,COG3829@2|Bacteria,3TAI8@508458|Synergistetes	508458|Synergistetes	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9
CMS2_k127_5680283_27	880073.Calab_2079	2.729e-65	240.0	COG1668@1|root,COG1668@2|Bacteria,2NPCQ@2323|unclassified Bacteria	2|Bacteria	CP	ABC-2 family transporter protein	natB	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
CMS2_k127_5680283_19	1047013.AQSP01000052_gene2600	1.037e-91	312.0	COG4152@1|root,COG4152@2|Bacteria,2NQE2@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4162)	natA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS2_k127_5680283_10	585530.HMPREF0183_1107	1.591e-138	448.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4F90U@85019|Brevibacteriaceae	201174|Actinobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
CMS2_k127_5680283_48	443143.GM18_1328	1.626e-17	89.0	COG3599@1|root,COG3599@2|Bacteria,1NCAV@1224|Proteobacteria,42VH6@68525|delta/epsilon subdivisions,2WS27@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	PFAM DivIVA family protein	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
CMS2_k127_5680283_52	1548151.LS70_07710	1.514e-13	75.0	COG0762@1|root,COG0762@2|Bacteria,1QDB9@1224|Proteobacteria,42VCU@68525|delta/epsilon subdivisions,2YQ8B@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
CMS2_k127_5680283_30	610130.Closa_2033	1.688e-55	201.0	COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,21Y81@1506553|Lachnoclostridium	186801|Clostridia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	ylmE	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
CMS2_k127_5680283_20	1379698.RBG1_1C00001G1097	3.191e-82	286.0	COG0820@1|root,COG0820@2|Bacteria,2NP4V@2323|unclassified Bacteria	2|Bacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
CMS2_k127_5680283_11	1313304.CALK_0297	1.593e-138	463.0	COG4581@1|root,COG4581@2|Bacteria	2|Bacteria	L	dead DEAH box helicase	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
CMS2_k127_5680283_28	592026.GCWU0000282_000387	6.713e-63	227.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia	186801|Clostridia	J	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
CMS2_k127_5680283_17	1232410.KI421418_gene2309	1.164e-102	358.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,43RZS@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
CMS2_k127_5680283_31	1163730.FFONT_0979	1.835e-48	177.0	COG0537@1|root,arCOG00419@2157|Archaea,2XQK8@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
CMS2_k127_5680283_40	1123242.JH636434_gene4961	8.099e-27	126.0	COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria,2J3IX@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,TPR_16,TPR_19,TPR_2
CMS2_k127_5680283_12	1047013.AQSP01000138_gene1037	2.582e-130	428.0	COG0124@1|root,COG0124@2|Bacteria,2NNZ7@2323|unclassified Bacteria	2|Bacteria	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
CMS2_k127_5680283_5	1047013.AQSP01000138_gene1038	1.272e-167	544.0	COG0173@1|root,COG0173@2|Bacteria,2NNP3@2323|unclassified Bacteria	2|Bacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iJN678.aspS,iSFV_1184.SFV_1868	GAD,tRNA-synt_2,tRNA_anti-codon
CMS2_k127_5684677_10	762903.Pedsa_3416	4.904e-49	177.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,4NFRF@976|Bacteroidetes,1IR6C@117747|Sphingobacteriia	976|Bacteroidetes	E	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
CMS2_k127_5684677_3	1408424.JHYI01000042_gene83	3.311e-117	402.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,1ZM6E@1386|Bacillus	91061|Bacilli	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS2_k127_5684677_20	1131462.DCF50_p19	1.396e-10	70.0	2BDY5@1|root,327NE@2|Bacteria,1VKFE@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5684677_4	1121859.KB890755_gene1090	3.441e-105	361.0	COG0796@1|root,COG0796@2|Bacteria,4NIZ7@976|Bacteroidetes	976|Bacteroidetes	M	Asp/Glu/Hydantoin racemase	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Glu_race
CMS2_k127_5684677_2	388413.ALPR1_17218	3.497e-156	509.0	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,47KC3@768503|Cytophagia	976|Bacteroidetes	Q	PFAM D-aminoacylase, C-terminal region	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
CMS2_k127_5684677_16	1094980.Mpsy_1605	4.898e-28	117.0	arCOG02435@1|root,arCOG02435@2157|Archaea,2XX22@28890|Euryarchaeota,2NAYP@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base	-	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009123,GO:0009125,GO:0009159,GO:0009162,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070694,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
CMS2_k127_5684677_19	522772.Dacet_0049	4.463e-13	82.0	COG0297@1|root,COG0297@2|Bacteria,2GF9C@200930|Deferribacteres	200930|Deferribacteres	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	-	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
CMS2_k127_5684677_5	195103.CPF_2819	1.804e-97	332.0	COG1972@1|root,COG1972@2|Bacteria,1TRSK@1239|Firmicutes,249IZ@186801|Clostridia,36FNG@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
CMS2_k127_5684677_8	351160.LRC41	2.159e-68	244.0	COG2309@1|root,arCOG01890@2157|Archaea	2157|Archaea	E	Leucyl aminopeptidase (Aminopeptidase t)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
CMS2_k127_5684677_0	1047013.AQSP01000039_gene1087	5.028e-175	572.0	COG0317@1|root,COG0317@2|Bacteria,2NNM0@2323|unclassified Bacteria	2|Bacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
CMS2_k127_5684677_11	1121324.CLIT_2c02100	1.956e-46	173.0	COG1636@1|root,COG1636@2|Bacteria,1TT7H@1239|Firmicutes,248EA@186801|Clostridia,25RIZ@186804|Peptostreptococcaceae	186801|Clostridia	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
CMS2_k127_5684677_7	1304885.AUEY01000025_gene2740	8.713e-76	259.0	COG3369@1|root,COG3592@1|root,COG3369@2|Bacteria,COG3592@2|Bacteria,1PMC1@1224|Proteobacteria,430UF@68525|delta/epsilon subdivisions,2WVWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Iron-binding zinc finger CDGSH type	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_19,zf-CDGSH
CMS2_k127_5684677_17	1242864.D187_003336	1.007e-23	106.0	COG0664@1|root,COG0664@2|Bacteria,1NBX3@1224|Proteobacteria,42UGQ@68525|delta/epsilon subdivisions,2WQY8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
CMS2_k127_5684677_12	880073.Calab_1079	3.499e-46	180.0	COG0767@1|root,COG0767@2|Bacteria,2NPFZ@2323|unclassified Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents permease component	mlaE_1	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
CMS2_k127_5684677_9	1121447.JONL01000004_gene2670	6.363e-63	224.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42RUE@68525|delta/epsilon subdivisions,2WV39@28221|Deltaproteobacteria,2MG5G@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	ATPases associated with a variety of cellular activities	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
CMS2_k127_5684677_15	459349.CLOAM1097	7.655e-32	137.0	COG1463@1|root,COG1463@2|Bacteria,2NQ4Z@2323|unclassified Bacteria	2|Bacteria	Q	MlaD protein	MA20_08125	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
CMS2_k127_5684677_18	1313304.CALK_1530	3.973e-13	77.0	COG3218@1|root,COG3218@2|Bacteria	2|Bacteria	Q	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K18480	-	M00669	-	-	ko00000,ko00002,ko02000	3.A.1.27.1	-	-	ABC_trans_aux
CMS2_k127_5684677_6	234267.Acid_5820	1.44e-93	330.0	COG0312@1|root,COG0312@2|Bacteria,3Y686@57723|Acidobacteria	57723|Acidobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
CMS2_k127_5684677_1	234267.Acid_5819	4.26e-168	545.0	COG0312@1|root,COG0312@2|Bacteria,3Y3MT@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
CMS2_k127_5684677_14	1122176.KB903565_gene3299	4.701e-32	132.0	COG3150@1|root,COG3150@2|Bacteria,4NZAP@976|Bacteroidetes	976|Bacteroidetes	S	Uncharacterised protein family (UPF0227)	-	-	-	ko:K07000	-	-	-	-	ko00000	-	-	-	NT5C,UPF0227
CMS2_k127_5684677_13	439235.Dalk_2288	3.96e-35	151.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,2MPW6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4150,RHS,RHS_repeat,Transglut_core
CMS2_k127_5726073_0	102232.GLO73106DRAFT_00031350	6.745e-18	89.0	COG1848@1|root,COG1848@2|Bacteria,1G51H@1117|Cyanobacteria	1117|Cyanobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_5726073_1	102232.GLO73106DRAFT_00031350	4.551e-13	72.0	COG1848@1|root,COG1848@2|Bacteria,1G51H@1117|Cyanobacteria	1117|Cyanobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_5726073_3	1123400.KB904803_gene1672	9.996e-11	62.0	COG1848@1|root,COG1848@2|Bacteria,1RFYN@1224|Proteobacteria,1T106@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5726073_5	449447.MAE_07890	7.691e-07	62.0	COG1413@1|root,COG5635@1|root,COG1413@2|Bacteria,COG5635@2|Bacteria,1G233@1117|Cyanobacteria	1117|Cyanobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Metallophos,NACHT,NB-ARC,Peptidase_C14
CMS2_k127_5726073_4	658086.HMPREF0994_00372	2.894e-08	60.0	COG1396@1|root,COG1396@2|Bacteria,1TVCG@1239|Firmicutes,25AGD@186801|Clostridia,27QE1@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5745903_0	1232437.KL661963_gene3380	6.071e-162	518.0	COG1148@1|root,COG1148@2|Bacteria,1N26U@1224|Proteobacteria,43BRX@68525|delta/epsilon subdivisions,2WKFG@28221|Deltaproteobacteria,2MJAN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
CMS2_k127_5745974_1	1047013.AQSP01000124_gene2663	4.321e-51	186.0	28JE3@1|root,2Z98B@2|Bacteria,2NQ8M@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS2_k127_5745974_2	351160.RCIX1830	4.884e-49	184.0	COG0842@1|root,arCOG01463@2157|Archaea,2XXQI@28890|Euryarchaeota,2N9MG@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
CMS2_k127_5745974_0	264732.Moth_0874	4.586e-94	317.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,42FQ5@68295|Thermoanaerobacterales	186801|Clostridia	V	pfam abc	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
CMS2_k127_5759711_1	1122947.FR7_2699	2.231e-47	190.0	COG0515@1|root,COG0515@2|Bacteria	1122947.FR7_2699|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5759711_0	457415.HMPREF1006_01424	1.159e-60	224.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase,UPF0020
CMS2_k127_5759711_2	269797.Mbar_A2597	2.027e-16	86.0	COG0457@1|root,arCOG06785@1|root,arCOG03047@2157|Archaea,arCOG06785@2157|Archaea,2Y7RD@28890|Euryarchaeota	28890|Euryarchaeota	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_7
CMS2_k127_5770550_0	290399.Arth_3178	4.097e-131	476.0	COG1404@1|root,COG4932@1|root,COG1404@2|Bacteria,COG4932@2|Bacteria,2GQDQ@201174|Actinobacteria,1WBJI@1268|Micrococcaceae	201174|Actinobacteria	MO	S-layer domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,SLH
CMS2_k127_5770550_7	1118058.CAGY01000002_gene772	9.762e-05	58.0	COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,2I66Z@201174|Actinobacteria,4D38B@85005|Actinomycetales	201174|Actinobacteria	M	SdrD B-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
CMS2_k127_5770550_6	1443122.Z958_03065	9.762e-05	58.0	COG4932@1|root,COG4932@2|Bacteria,1V3NP@1239|Firmicutes,24J6W@186801|Clostridia,36IXS@31979|Clostridiaceae	186801|Clostridia	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS2_k127_5770550_3	1191523.MROS_2005	4.226e-76	294.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5770550_1	1304885.AUEY01000005_gene893	2.095e-105	360.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42MCH@68525|delta/epsilon subdivisions,2WJPZ@28221|Deltaproteobacteria,2MIEC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_5770550_5	526225.Gobs_0746	5.644e-05	45.0	COG1262@1|root,COG3170@1|root,COG1262@2|Bacteria,COG3170@2|Bacteria,2IBYZ@201174|Actinobacteria	201174|Actinobacteria	NU	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	PknH_C,TIR_2
CMS2_k127_5770550_4	452637.Oter_4143	1.226e-43	164.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
CMS2_k127_5770550_2	177437.HRM2_16410	2.357e-96	322.0	COG0589@1|root,COG0589@2|Bacteria,1R51N@1224|Proteobacteria,42PVP@68525|delta/epsilon subdivisions,2WKQB@28221|Deltaproteobacteria,2MINR@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response to stress	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5770550_8	1047013.AQSP01000142_gene167	0.0006569	51.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	ywhL	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
CMS2_k127_5795509_29	335543.Sfum_2943	1.198e-27	117.0	COG0784@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg,dCache_1
CMS2_k127_5795509_5	880073.Calab_0508	8.634e-169	580.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_9,Response_reg
CMS2_k127_5795509_6	880073.Calab_0508	4.047e-141	492.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_9,Response_reg
CMS2_k127_5795509_7	1047013.AQSP01000137_gene554	3.523e-133	449.0	COG2091@1|root,COG2091@2|Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_5795509_10	37659.JNLN01000001_gene2808	7.202e-96	326.0	COG0028@1|root,COG0028@2|Bacteria,1TSJZ@1239|Firmicutes,24AIU@186801|Clostridia,36F1Y@31979|Clostridiaceae	186801|Clostridia	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	aepY	-	4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R04053	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
CMS2_k127_5795509_18	247634.GPB2148_2396	9.119e-53	201.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	alcohol dehydrogenase	eutG	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
CMS2_k127_5795509_36	236814.IX39_09560	0.0004632	55.0	2EY6R@1|root,33RFD@2|Bacteria,4P03A@976|Bacteroidetes,1I79Y@117743|Flavobacteriia,3ZQAQ@59732|Chryseobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5795509_37	132908.ENSPVAP00000009082	0.0008264	43.0	KOG1217@1|root,KOG1217@2759|Eukaryota,38BUP@33154|Opisthokonta,3BA2W@33208|Metazoa,3D3UH@33213|Bilateria,48C98@7711|Chordata,493M9@7742|Vertebrata,3J8TZ@40674|Mammalia,4M56X@9397|Chiroptera	33208|Metazoa	T	EGF domain	FBN3	GO:0003674,GO:0005198,GO:0005201,GO:0005575,GO:0005576,GO:0008150,GO:0009653,GO:0031012,GO:0032502,GO:0044421,GO:0048583,GO:0048856,GO:0050789,GO:0050794,GO:0065007,GO:0090287	-	ko:K06825	-	-	-	-	ko00000,ko00536,ko04516	-	-	-	EGF_CA,TB,hEGF
CMS2_k127_5795509_2	1168034.FH5T_10680	2.595e-184	590.0	COG2509@1|root,COG2509@2|Bacteria,4NEUQ@976|Bacteroidetes,2FM1G@200643|Bacteroidia	976|Bacteroidetes	S	Psort location Cytoplasmic, score	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_binding_3,GIDA,HI0933_like,Pyr_redox_2
CMS2_k127_5795509_25	1173024.KI912149_gene5115	3.892e-38	146.0	COG4634@1|root,COG4634@2|Bacteria,1G760@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5795509_28	163908.KB235896_gene3284	6.318e-28	115.0	COG2442@1|root,COG2442@2|Bacteria,1GACC@1117|Cyanobacteria,1HQ0P@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
CMS2_k127_5795509_21	1499967.BAYZ01000088_gene5065	2.327e-45	170.0	COG2365@1|root,COG2365@2|Bacteria	2|Bacteria	T	protein tyrosine phosphatase activity	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	DSPc,Y_phosphatase2,Y_phosphatase3
CMS2_k127_5795509_24	1047013.AQSP01000081_gene102	1.145e-42	164.0	COG0602@1|root,COG0602@2|Bacteria,2NPEM@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047	1.97.1.4,4.3.99.3	ko:K04068,ko:K10026	ko00790,ko01100,map00790,map01100	-	R04710,R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
CMS2_k127_5795509_30	667014.Thein_0896	1.413e-18	90.0	COG0720@1|root,COG0720@2|Bacteria,2GHTY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
CMS2_k127_5795509_15	868864.Dester_1387	2.356e-69	242.0	COG0603@1|root,COG0603@2|Bacteria,2G41N@200783|Aquificae	200783|Aquificae	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
CMS2_k127_5795509_4	1408473.JHXO01000004_gene100	9.084e-175	552.0	COG0078@1|root,COG0078@2|Bacteria,4NEYX@976|Bacteroidetes,2FPNE@200643|Bacteroidia	976|Bacteroidetes	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS2_k127_5795509_8	941824.TCEL_01859	1.549e-119	394.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,36DRW@31979|Clostridiaceae	186801|Clostridia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430	GcpE
CMS2_k127_5795509_20	335543.Sfum_0771	4.115e-46	170.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,42SJ8@68525|delta/epsilon subdivisions,2WP5B@28221|Deltaproteobacteria,2MQHT@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
CMS2_k127_5795509_16	926561.KB900617_gene1766	3.293e-64	235.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3WAE6@53433|Halanaerobiales	186801|Clostridia	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
CMS2_k127_5795509_27	926561.KB900617_gene2315	1.483e-31	132.0	COG2344@1|root,COG2344@2|Bacteria,1TSMR@1239|Firmicutes,247RQ@186801|Clostridia,3WBRT@53433|Halanaerobiales	186801|Clostridia	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
CMS2_k127_5795509_12	879212.DespoDRAFT_00314	1.365e-72	248.0	COG0652@1|root,COG0652@2|Bacteria,1R4KH@1224|Proteobacteria,42R08@68525|delta/epsilon subdivisions,2X5NA@28221|Deltaproteobacteria,2MPXU@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
CMS2_k127_5795509_3	1047013.AQSP01000101_gene606	2.244e-180	575.0	COG0006@1|root,COG0006@2|Bacteria,2NP8P@2323|unclassified Bacteria	2|Bacteria	E	Metallopeptidase family M24	pepQ	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
CMS2_k127_5795509_0	1047013.AQSP01000135_gene1587	1.023e-312	977.0	COG0495@1|root,COG0495@2|Bacteria,2NNQH@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_2300	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
CMS2_k127_5795509_33	204669.Acid345_2357	2.606e-16	86.0	COG2980@1|root,COG2980@2|Bacteria,3Y4V4@57723|Acidobacteria,2JJKB@204432|Acidobacteriia	204432|Acidobacteriia	M	Lipopolysaccharide-assembly	-	-	-	-	-	-	-	-	-	-	-	-	LptE
CMS2_k127_5795509_34	1423775.BAMN01000007_gene1138	4.677e-15	87.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,4HBB4@91061|Bacilli,3F3TP@33958|Lactobacillaceae	91061|Bacilli	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
CMS2_k127_5795509_32	880073.Calab_1843	3.346e-17	96.0	COG0457@1|root,COG0457@2|Bacteria,2NPEN@2323|unclassified Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
CMS2_k127_5795509_11	272558.10173311	3.035e-81	277.0	COG3340@1|root,COG3340@2|Bacteria,1TRBA@1239|Firmicutes,4HB19@91061|Bacilli,1ZC4Z@1386|Bacillus	91061|Bacilli	E	Belongs to the peptidase S51 family	ygaJ	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564	3.4.13.21	ko:K05995	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
CMS2_k127_5795509_9	439235.Dalk_0237	5.709e-103	369.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_5795509_26	644282.Deba_1334	5.062e-33	149.0	COG4412@1|root,COG4412@2|Bacteria,1RKAD@1224|Proteobacteria,43ARU@68525|delta/epsilon subdivisions,2X65X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
CMS2_k127_5795509_17	329726.AM1_4632	6.926e-54	200.0	COG3735@1|root,COG3735@2|Bacteria,1G6DE@1117|Cyanobacteria	1117|Cyanobacteria	S	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
CMS2_k127_5795509_19	1120998.AUFC01000012_gene536	9.574e-52	193.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,3WCG5@538999|Clostridiales incertae sedis	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
CMS2_k127_5795509_31	1047013.AQSP01000068_gene2281	1.196e-17	97.0	28WP9@1|root,2ZINZ@2|Bacteria	1047013.AQSP01000068_gene2281|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5795509_14	243275.TDE_0955	1.281e-70	244.0	COG1704@1|root,COG1704@2|Bacteria,2J65U@203691|Spirochaetes	203691|Spirochaetes	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
CMS2_k127_5795509_22	243275.TDE_2528	4.037e-44	169.0	COG3762@1|root,COG3762@2|Bacteria,2J6T4@203691|Spirochaetes	203691|Spirochaetes	S	Membrane	-	-	-	ko:K08988	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
CMS2_k127_5795509_23	290317.Cpha266_2021	6.017e-43	167.0	COG1512@1|root,COG1512@2|Bacteria,1FEGA@1090|Chlorobi	1090|Chlorobi	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
CMS2_k127_5795509_1	1121403.AUCV01000031_gene2838	9.494e-268	859.0	COG1361@1|root,COG3540@1|root,COG4733@1|root,COG1361@2|Bacteria,COG3540@2|Bacteria,COG4733@2|Bacteria,1QVSF@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,OmpA_membrane
CMS2_k127_581527_1	1121121.KB894285_gene20	0.0	1315.0	COG0300@1|root,COG0454@1|root,COG3321@1|root,COG0300@2|Bacteria,COG0456@2|Bacteria,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_581527_0	1121121.KB894285_gene20	0.0	2664.0	COG0300@1|root,COG0454@1|root,COG3321@1|root,COG0300@2|Bacteria,COG0456@2|Bacteria,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_581527_2	1168034.FH5T_01595	3.893e-114	380.0	COG1520@1|root,COG1520@2|Bacteria,4P28I@976|Bacteroidetes,2FX0J@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_581527_3	449447.MAE_50260	2.98e-108	362.0	COG1396@1|root,COG2856@1|root,COG1396@2|Bacteria,COG2856@2|Bacteria,1GAYI@1117|Cyanobacteria	1117|Cyanobacteria	K	Pfam:DUF955	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Peptidase_M78
CMS2_k127_581527_5	269482.Bcep1808_3375	6.139e-39	151.0	COG1439@1|root,COG1439@2|Bacteria,1N0N0@1224|Proteobacteria,2W55H@28216|Betaproteobacteria,1KC1U@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4411)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4411
CMS2_k127_581527_4	521674.Plim_3220	3.117e-51	195.0	COG5635@1|root,COG5635@2|Bacteria	2|Bacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,TIR_2
CMS2_k127_581527_7	228399.appser1_10630	1.956e-18	87.0	COG2801@1|root,COG2801@2|Bacteria,1PDT5@1224|Proteobacteria,1SY1J@1236|Gammaproteobacteria,1YAMN@135625|Pasteurellales	135625|Pasteurellales	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_581527_8	665571.STHERM_c17450	3.822e-16	81.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	3.1.21.3	ko:K01154,ko:K07076,ko:K18842	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	NTP_transf_2
CMS2_k127_581527_6	795359.TOPB45_1232	7.329e-32	129.0	COG2250@1|root,COG2250@2|Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_5816229_8	585501.HMPREF6123_2084	0.0008199	48.0	COG1476@1|root,COG1476@2|Bacteria,1V624@1239|Firmicutes,24K9D@186801|Clostridia,2PSD6@265975|Oribacterium	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS2_k127_5816229_0	926549.KI421517_gene455	6.813e-102	342.0	COG2234@1|root,COG2234@2|Bacteria,4NIQX@976|Bacteroidetes,47MWW@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS2_k127_5816229_1	449447.MAE_01800	2.352e-93	315.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria	1117|Cyanobacteria	O	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2
CMS2_k127_5816229_7	5888.CAK86537	7.923e-06	49.0	COG3914@1|root,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
CMS2_k127_5816229_2	1121935.AQXX01000072_gene5	9.608e-30	136.0	COG1994@1|root,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria,1RQY8@1236|Gammaproteobacteria,1XIRU@135619|Oceanospirillales	135619|Oceanospirillales	S	COG1994 Zn-dependent proteases	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5816229_6	1229172.JQFA01000002_gene3740	3.429e-10	65.0	COG1708@1|root,COG1708@2|Bacteria,1G8F3@1117|Cyanobacteria,1HFX4@1150|Oscillatoriales	1117|Cyanobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CMS2_k127_5816229_4	1499967.BAYZ01000191_gene3928	2.413e-15	80.0	COG2250@1|root,COG2250@2|Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_5816229_5	324925.Ppha_1047	1.656e-11	70.0	COG1262@1|root,COG1409@1|root,COG5635@1|root,COG1262@2|Bacteria,COG1409@2|Bacteria,COG5635@2|Bacteria,1FEK9@1090|Chlorobi	2|Bacteria	T	NACHT nucleoside triphosphatase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,Metallophos,PEGA
CMS2_k127_5831011_7	1499967.BAYZ01000102_gene3573	4.439e-68	247.0	COG3979@1|root,COG3979@2|Bacteria	2|Bacteria	S	chitin catabolic process	chiA	GO:0003674,GO:0003824,GO:0004553,GO:0004568,GO:0005575,GO:0005623,GO:0008843,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.2.1.14,3.2.1.17	ko:K01183,ko:K03933,ko:K13381	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	AA10,CBM15,CBM73,GH18	-	CBM_5_12,DUF5011,LPMO_10,Peptidase_M60
CMS2_k127_5831011_8	880073.Calab_2198	1.137e-64	230.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K02660,ko:K11525	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,EAL,GAF,GGDEF,HAMP,MCPsignal,PAS_3,PAS_4,PAS_7,dCache_1
CMS2_k127_5831011_6	880073.Calab_2198	1.923e-69	244.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K02660,ko:K11525	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,EAL,GAF,GGDEF,HAMP,MCPsignal,PAS_3,PAS_4,PAS_7,dCache_1
CMS2_k127_5831011_3	706587.Desti_0040	6.516e-133	445.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WIRT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	ATP-binding region ATPase domain protein	cheA4	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,HATPase_c,Hpt,Response_reg
CMS2_k127_5831011_4	269799.Gmet_2709	1.307e-105	362.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42N1S@68525|delta/epsilon subdivisions,2WK7R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	mcp40H-21	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,HAMP,MCPsignal,dCache_1
CMS2_k127_5831011_13	706587.Desti_0039	3.509e-34	139.0	COG0835@1|root,COG0835@2|Bacteria,1RJKY@1224|Proteobacteria,42SN3@68525|delta/epsilon subdivisions,2WPCG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
CMS2_k127_5831011_10	573413.Spirs_2269	8.635e-46	174.0	COG2935@1|root,COG2935@2|Bacteria	2|Bacteria	O	arginyltransferase activity	ate	GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
CMS2_k127_5831011_12	1033810.HLPCO_001694	1.947e-42	160.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_5831011_16	1047013.AQSP01000058_gene2029	4.206e-06	58.0	2DH1X@1|root,2ZY43@2|Bacteria	1047013.AQSP01000058_gene2029|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5831011_5	1121104.AQXH01000001_gene1325	1.688e-78	291.0	COG1033@1|root,COG1033@2|Bacteria	2|Bacteria	S	growth of symbiont in host cell	hpnN	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS2_k127_5831011_9	1239962.C943_01022	3.02e-59	215.0	COG0457@1|root,COG0457@2|Bacteria,4P246@976|Bacteroidetes,47PGN@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF2911)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2911
CMS2_k127_5831011_0	1121904.ARBP01000007_gene2953	8.939e-241	771.0	COG2120@1|root,COG2120@2|Bacteria,4NE9K@976|Bacteroidetes,47KXK@768503|Cytophagia	976|Bacteroidetes	G	PFAM GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS2_k127_5831011_2	1047013.AQSP01000125_gene2632	2.762e-196	627.0	COG0591@1|root,COG0591@2|Bacteria,2NR0M@2323|unclassified Bacteria	2|Bacteria	E	Sodium:solute symporter family	yidK	-	-	-	-	-	-	-	-	-	-	-	SSF
CMS2_k127_5831011_11	215803.DB30_7087	3.169e-44	171.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,42MBJ@68525|delta/epsilon subdivisions,2WNWX@28221|Deltaproteobacteria,2YZPF@29|Myxococcales	28221|Deltaproteobacteria	M	Transglycosylase	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
CMS2_k127_5831011_17	59931.WH7805_02087	0.0009954	50.0	2B86Z@1|root,321FH@2|Bacteria,1GMI7@1117|Cyanobacteria,1GZ3Q@1129|Synechococcus	1117|Cyanobacteria	S	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
CMS2_k127_5831011_15	1262449.CP6013_2410	5.775e-10	72.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,36DBS@31979|Clostridiaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_5831011_1	1237149.C900_04816	9.914e-232	768.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47TR0@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Response_reg,Y_Y_Y
CMS2_k127_5831011_14	215803.DB30_0397	2.697e-24	109.0	COG0739@1|root,COG3271@1|root,COG0739@2|Bacteria,COG3271@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K03791	-	-	-	-	ko00000	-	GH19	-	DUF4185,Peptidase_C39_2,Peptidase_C70,Peptidase_M23
CMS2_k127_5849574_16	1232410.KI421421_gene3333	7.993e-10	60.0	COG3237@1|root,COG3237@2|Bacteria,1NGW6@1224|Proteobacteria,42XTD@68525|delta/epsilon subdivisions,2WT90@28221|Deltaproteobacteria,43VVU@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	CsbD-like	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
CMS2_k127_5849574_15	644282.Deba_0484	1.837e-13	75.0	2ESCT@1|root,33JXK@2|Bacteria,1NK92@1224|Proteobacteria,42Y2H@68525|delta/epsilon subdivisions,2WSPA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5849574_0	439235.Dalk_0736	5.518e-169	543.0	COG2204@1|root,COG2204@2|Bacteria,1MVWX@1224|Proteobacteria,42MIB@68525|delta/epsilon subdivisions,2WJQK@28221|Deltaproteobacteria,2MHU2@213118|Desulfobacterales	28221|Deltaproteobacteria	T	sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_5849574_14	931626.Awo_c14850	1.833e-14	75.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia,25VEF@186806|Eubacteriaceae	186801|Clostridia	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS2_k127_5849574_10	269799.Gmet_0814	2.157e-43	164.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WISZ@28221|Deltaproteobacteria,43S6P@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS2_k127_5849574_8	1047013.AQSP01000112_gene391	1.807e-51	199.0	COG3307@1|root,COG3307@2|Bacteria,2NPHS@2323|unclassified Bacteria	2|Bacteria	M	O-Antigen ligase	tuaE	-	-	ko:K16705	-	-	-	-	ko00000	-	-	-	Wzy_C
CMS2_k127_5849574_3	1047013.AQSP01000112_gene392	4.128e-138	466.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2NNNP@2323|unclassified Bacteria	2|Bacteria	D	CobQ CobB MinD ParA nucleotide binding domain	ywqD	-	2.7.10.1	ko:K08252,ko:K13661,ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
CMS2_k127_5849574_19	234267.Acid_1525	0.0001659	51.0	COG4932@1|root,COG4932@2|Bacteria,3Y53F@57723|Acidobacteria	57723|Acidobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS2_k127_5849574_9	335543.Sfum_4010	2.386e-45	177.0	COG1117@1|root,COG1117@2|Bacteria,1NMB4@1224|Proteobacteria,42XIZ@68525|delta/epsilon subdivisions,2WTEA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase-coupled phosphate ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5849574_6	335543.Sfum_4009	4.77e-82	287.0	COG0535@1|root,COG0535@2|Bacteria,1MYFX@1224|Proteobacteria,42SB0@68525|delta/epsilon subdivisions,2WPF4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS2_k127_5849574_17	694427.Palpr_1116	9.533e-10	63.0	2A7H6@1|root,30WES@2|Bacteria,4P9V3@976|Bacteroidetes,2FVJ4@200643|Bacteroidia	976|Bacteroidetes	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
CMS2_k127_5849574_1	335543.Sfum_4007	1.93e-168	587.0	COG1572@1|root,COG1572@2|Bacteria,1N1AP@1224|Proteobacteria	1224|Proteobacteria	S	Peptidase family C25	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
CMS2_k127_5849574_11	99598.Cal7507_5238	8.16e-35	156.0	COG4932@1|root,COG4932@2|Bacteria,1GIGN@1117|Cyanobacteria,1HKKY@1161|Nostocales	1117|Cyanobacteria	M	Cna protein B-type domain	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
CMS2_k127_5849574_5	439235.Dalk_0237	7.655e-98	361.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_5849574_4	1444711.CCJF01000005_gene546	1.115e-137	484.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta,SBBP
CMS2_k127_5849574_2	909663.KI867150_gene971	1.25e-156	505.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2X1VS@28221|Deltaproteobacteria,2MRES@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_5849574_13	933262.AXAM01000014_gene262	5.409e-17	94.0	COG0025@1|root,COG0025@2|Bacteria,1N7PG@1224|Proteobacteria,42V45@68525|delta/epsilon subdivisions,2WRJ6@28221|Deltaproteobacteria,2MN9H@213118|Desulfobacterales	28221|Deltaproteobacteria	P	NhaP-type Na H and K H	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5849574_7	880073.Calab_0958	2.896e-66	242.0	COG0475@1|root,COG0475@2|Bacteria	2|Bacteria	P	glutathione-regulated potassium exporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
CMS2_k127_5861976_6	755731.Clo1100_1301	6.629e-120	397.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,Thioesterase,ketoacyl-synt
CMS2_k127_5861976_5	1163617.SCD_n00016	8.812e-122	396.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VK44@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
CMS2_k127_5861976_23	1304885.AUEY01000004_gene991	2.937e-06	57.0	2EBYR@1|root,335Y1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5861976_22	387631.Asulf_00521	2.286e-07	64.0	COG3979@1|root,COG5306@1|root,arCOG02420@1|root,arCOG03511@1|root,arCOG03553@1|root,arCOG09173@1|root,arCOG02420@2157|Archaea,arCOG03508@2157|Archaea,arCOG03511@2157|Archaea,arCOG03553@2157|Archaea,arCOG07581@2157|Archaea,arCOG09173@2157|Archaea	2157|Archaea	C	PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF2341,PKD,Pilin_N,S_layer_C
CMS2_k127_5861976_21	697281.Mahau_1679	1.232e-10	75.0	COG0845@1|root,COG0845@2|Bacteria,1V2JZ@1239|Firmicutes,24A5A@186801|Clostridia,42GMT@68295|Thermoanaerobacterales	186801|Clostridia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888,ko:K15727	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1,8.A.1.2.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP
CMS2_k127_5861976_16	1333523.L593_10660	1.691e-35	156.0	COG3291@1|root,COG3325@1|root,arCOG02546@2157|Archaea,arCOG07840@2157|Archaea,2Y7YU@28890|Euryarchaeota,241E0@183963|Halobacteria	183963|Halobacteria	G	chitinase	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Glyco_hydro_18,PKD
CMS2_k127_5861976_10	1250232.JQNJ01000001_gene1912	8.129e-77	273.0	COG1680@1|root,COG4319@1|root,COG1680@2|Bacteria,COG4319@2|Bacteria,4NER1@976|Bacteroidetes	976|Bacteroidetes	V	Beta-lactamase class C and other penicillin binding	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
CMS2_k127_5861976_15	1047013.AQSP01000139_gene2383	4.56e-53	206.0	COG0457@1|root,COG0484@1|root,COG0457@2|Bacteria,COG0484@2|Bacteria,2NRMR@2323|unclassified Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	ko:K05516,ko:K05801	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DUF4388,DnaJ,DnaJ_C,TerB,WD40
CMS2_k127_5861976_18	665571.STHERM_c03740	2.586e-26	113.0	COG1762@1|root,COG1762@2|Bacteria,2J5KE@203691|Spirochaetes	203691|Spirochaetes	G	DNA-binding protein PTS system, IIA component	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
CMS2_k127_5861976_1	1047013.AQSP01000134_gene1371	4.663e-309	963.0	COG0531@1|root,COG0589@1|root,COG0531@2|Bacteria,COG0589@2|Bacteria,2NS54@2323|unclassified Bacteria	2|Bacteria	E	Amino acid permease	ybaT	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009268,GO:0009628,GO:0010035,GO:0010038,GO:0016020,GO:0042221,GO:0044464,GO:0046688,GO:0050896,GO:0071944,GO:0097501,GO:1990169	-	ko:K07076,ko:K11932,ko:K16263	-	-	-	-	ko00000,ko02000	2.A.3.13	-	-	AA_permease_2,Usp
CMS2_k127_5861976_13	335543.Sfum_2303	2.282e-61	218.0	COG2199@1|root,COG3706@2|Bacteria,1QWNG@1224|Proteobacteria,42SDQ@68525|delta/epsilon subdivisions,2WP1N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_5861976_0	1047013.AQSP01000108_gene2058	0.0	1090.0	COG2091@1|root,COG2091@2|Bacteria,2NQGR@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_5861976_7	582744.Msip34_0973	2.651e-116	399.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,2KKPG@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
CMS2_k127_5861976_14	765912.Thimo_2697	1.857e-57	211.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1WWD0@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS2_k127_5861976_8	497964.CfE428DRAFT_4774	3e-111	367.0	COG0714@1|root,COG0714@2|Bacteria,46SKP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM ATPase associated with various cellular activities AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS2_k127_5861976_2	1168034.FH5T_04755	2.985e-286	896.0	COG1509@1|root,COG1509@2|Bacteria,4NK6C@976|Bacteroidetes,2FMW5@200643|Bacteroidia	976|Bacteroidetes	E	KamA family	eam	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	-
CMS2_k127_5861976_11	880073.Calab_1592	6.644e-76	260.0	COG0009@1|root,COG0009@2|Bacteria,2NPMH@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the SUA5 family	yciO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
CMS2_k127_5861976_9	1047013.AQSP01000138_gene1057	5.08e-90	307.0	COG0533@1|root,COG0533@2|Bacteria,2NNXP@2323|unclassified Bacteria	2|Bacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	R10648	RC00070,RC00416	ko00000,ko00001,ko00002,ko01000,ko02044,ko03016	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Peptidase_M22
CMS2_k127_5861976_3	1379270.AUXF01000004_gene3330	1.662e-221	702.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1ZT6C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Methylenetetrahydrofolate reductase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
CMS2_k127_5861976_19	1123252.ATZF01000010_gene452	3.067e-26	111.0	COG1695@1|root,COG1695@2|Bacteria,1V85H@1239|Firmicutes,4HJMF@91061|Bacilli	91061|Bacilli	K	PadR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
CMS2_k127_5861976_12	439235.Dalk_0815	2.729e-63	224.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria,2MNC9@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CMS2_k127_5861976_4	938278.CAJO01000044_gene240	1.133e-123	422.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,267U0@186813|unclassified Clostridiales	186801|Clostridia	L	UvrD-like helicase C-terminal domain	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
CMS2_k127_5861976_20	483219.LILAB_34910	2.101e-23	109.0	COG0421@1|root,COG0421@2|Bacteria,1N1PJ@1224|Proteobacteria,43C7V@68525|delta/epsilon subdivisions,2X7I7@28221|Deltaproteobacteria,2Z1WH@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
CMS2_k127_5861976_24	349161.Dred_0517	9.656e-05	54.0	2BCHK@1|root,3263H@2|Bacteria,1US2N@1239|Firmicutes,24YAW@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5918324_0	1121405.dsmv_2653	5.355e-165	524.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,42RGI@68525|delta/epsilon subdivisions,2WNGP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_33
CMS2_k127_5918324_1	555779.Dthio_PD2895	6.915e-72	246.0	COG0582@1|root,COG0582@2|Bacteria,1RCN8@1224|Proteobacteria,42RD9@68525|delta/epsilon subdivisions,2WMVF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	viral genome integration into host DNA	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_integrase
CMS2_k127_5947460_1	373903.Hore_22330	6.434e-06	48.0	2DG7P@1|root,2ZUUE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5947460_0	522306.CAP2UW1_0277	2.059e-38	166.0	2CCB6@1|root,32YGR@2|Bacteria,1NC64@1224|Proteobacteria,2VWKT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
CMS2_k127_5947460_2	1133849.O3I_021840	6.601e-05	55.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,PKD
CMS2_k127_601342_2	138119.DSY4423	3.681e-104	354.0	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia,263EX@186807|Peptococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_601342_0	926692.AZYG01000012_gene877	5.341e-250	796.0	COG1033@1|root,COG1033@2|Bacteria	2|Bacteria	S	growth of symbiont in host cell	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS2_k127_601342_3	1235813.JCM10003_3414	1.848e-89	312.0	2EAQI@1|root,334SS@2|Bacteria,4PA6S@976|Bacteroidetes,2FW82@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_601342_5	573413.Spirs_1272	7.469e-81	278.0	COG1033@1|root,COG1033@2|Bacteria	2|Bacteria	S	growth of symbiont in host cell	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS2_k127_601342_1	1047013.AQSP01000132_gene1731	1.344e-124	427.0	COG0795@1|root,COG0795@2|Bacteria,2NP9S@2323|unclassified Bacteria	2|Bacteria	S	Permease YjgP YjgQ family protein	lptF	-	-	ko:K07091,ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
CMS2_k127_601342_11	1313421.JHBV01000024_gene4908	2.911e-31	128.0	COG2003@1|root,COG2003@2|Bacteria,4NP8R@976|Bacteroidetes	976|Bacteroidetes	L	RadC-like JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	RadC
CMS2_k127_601342_12	4565.Traes_2AS_6F423DB28.2	0.000119	49.0	KOG4475@1|root,KOG4661@1|root,KOG4475@2759|Eukaryota,KOG4661@2759|Eukaryota,37TDS@33090|Viridiplantae,3GFPB@35493|Streptophyta,3KV0H@4447|Liliopsida,3I7UD@38820|Poales	35493|Streptophyta	A	RNA recognition motif	-	-	-	ko:K12897	ko03040,map03040	-	-	-	ko00000,ko00001,ko01009,ko03041	-	-	-	RRM_1
CMS2_k127_601342_9	99598.Cal7507_1420	3.836e-33	138.0	COG3549@1|root,COG3549@2|Bacteria,1GPIM@1117|Cyanobacteria,1HSQ6@1161|Nostocales	1117|Cyanobacteria	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
CMS2_k127_601342_10	237368.SCABRO_02416	7.99e-32	127.0	COG3093@1|root,COG3093@2|Bacteria	2|Bacteria	K	addiction module antidote protein HigA	higA_2	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3,HTH_31
CMS2_k127_601342_8	268407.PWYN_06675	1.659e-54	199.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,4HABJ@91061|Bacilli,26RRC@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
CMS2_k127_601342_7	118161.KB235922_gene5699	9.44e-60	215.0	COG0411@1|root,COG0411@2|Bacteria,1G07Z@1117|Cyanobacteria,3VJFX@52604|Pleurocapsales	1117|Cyanobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	natA	-	-	ko:K01995,ko:K11957	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	ABC_tran,BCA_ABC_TP_C
CMS2_k127_601342_4	1047013.AQSP01000127_gene472	1.192e-85	292.0	COG4177@1|root,COG4177@2|Bacteria,2NPMP@2323|unclassified Bacteria	2|Bacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BPD_transp_2
CMS2_k127_601342_6	237368.SCABRO_03279	7.856e-75	261.0	COG0559@1|root,COG0559@2|Bacteria,2IWS7@203682|Planctomycetes	203682|Planctomycetes	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997,ko:K11960	ko02010,ko02024,map02010,map02024	M00237,M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
CMS2_k127_6024095_35	1123008.KB905693_gene1330	9.731e-23	102.0	COG4319@1|root,COG4319@2|Bacteria,4NT6G@976|Bacteroidetes,2FTV9@200643|Bacteroidia,22YRG@171551|Porphyromonadaceae	976|Bacteroidetes	S	Calcium/calmodulin dependent protein kinase II association domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
CMS2_k127_6024095_31	445971.ANASTE_00320	2.172e-30	127.0	COG4430@1|root,COG4430@2|Bacteria,1V1VF@1239|Firmicutes,249ZH@186801|Clostridia,25XQR@186806|Eubacteriaceae	186801|Clostridia	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
CMS2_k127_6024095_5	870187.Thini_2418	2.999e-143	462.0	COG3943@1|root,COG3943@2|Bacteria,1MWKW@1224|Proteobacteria,1RPNB@1236|Gammaproteobacteria,461CN@72273|Thiotrichales	72273|Thiotrichales	S	Virulence protein RhuM family	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_RhuM
CMS2_k127_6024095_3	1408473.JHXO01000006_gene1316	1.225e-157	504.0	COG0332@1|root,COG0332@2|Bacteria,4NEZE@976|Bacteroidetes,2FRWR@200643|Bacteroidia	976|Bacteroidetes	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS2_k127_6024095_38	1047013.AQSP01000058_gene2028	5.142e-05	55.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,TolB_like
CMS2_k127_6024095_0	1232410.KI421423_gene1902	0.0	1095.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria,43TEK@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
CMS2_k127_6024095_23	709032.Sulku_2429	5.376e-53	203.0	COG0834@1|root,COG2199@1|root,COG2202@1|root,COG3829@1|root,COG0834@2|Bacteria,COG2202@2|Bacteria,COG3706@2|Bacteria,COG3829@2|Bacteria,1R7HC@1224|Proteobacteria,42M3W@68525|delta/epsilon subdivisions,2YMI6@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	SMART GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3,PAS_9
CMS2_k127_6024095_10	555779.Dthio_PD0546	4.016e-127	413.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,2M938@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
CMS2_k127_6024095_4	1499967.BAYZ01000167_gene6714	2.816e-144	472.0	COG2195@1|root,COG2195@2|Bacteria,2NP2Y@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M20/M25/M40	pepD	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
CMS2_k127_6024095_12	177437.HRM2_46670	5.211e-107	359.0	COG0494@1|root,COG1194@1|root,COG0494@2|Bacteria,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,42PDR@68525|delta/epsilon subdivisions,2WJ60@28221|Deltaproteobacteria,2MI2R@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A G-specific adenine glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
CMS2_k127_6024095_37	338966.Ppro_2990	1.55e-10	73.0	COG3179@1|root,COG3179@2|Bacteria,1RC1P@1224|Proteobacteria	1224|Proteobacteria	E	Glycoside hydrolase, family 19	-	-	-	ko:K03791	-	-	-	-	ko00000	-	GH19	-	Glyco_hydro_19
CMS2_k127_6024095_1	1125863.JAFN01000001_gene1218	1.427e-264	840.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS2_k127_6024095_22	706587.Desti_1839	5.422e-59	208.0	COG2080@1|root,COG2080@2|Bacteria,1Q9C0@1224|Proteobacteria,42TB7@68525|delta/epsilon subdivisions,2WPGV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CMS2_k127_6024095_20	1184251.TCELL_1074	1.531e-61	227.0	COG1319@1|root,arCOG01926@2157|Archaea,2XQPN@28889|Crenarchaeota	28889|Crenarchaeota	C	CO dehydrogenase flavoprotein domain protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
CMS2_k127_6024095_7	76114.ebA2066	2.378e-133	438.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,2KXPJ@206389|Rhodocyclales	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS2_k127_6024095_2	1125863.JAFN01000001_gene1230	2.553e-160	512.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42Y7P@68525|delta/epsilon subdivisions,2WUJA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS2_k127_6024095_24	909663.KI867150_gene2003	1.006e-46	178.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WMYC@28221|Deltaproteobacteria,2MQGX@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
CMS2_k127_6024095_19	246194.CHY_1353	1.683e-71	253.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,42FKR@68295|Thermoanaerobacterales	186801|Clostridia	C	electron transfer flavoprotein, alpha subunit	etfA	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
CMS2_k127_6024095_13	643648.Slip_0457	9.153e-98	334.0	COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,2481K@186801|Clostridia,42JT5@68298|Syntrophomonadaceae	186801|Clostridia	C	FAD dependent oxidoreductase	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO
CMS2_k127_6024095_33	1125863.JAFN01000001_gene1226	1.553e-25	109.0	COG2440@1|root,COG2440@2|Bacteria,1RHTX@1224|Proteobacteria,42W4T@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	Could be a 3Fe-4S cluster-containing protein	fixX	-	-	ko:K03855	-	-	-	-	ko00000	-	-	-	ETF_QO
CMS2_k127_6024095_6	1123355.JHYO01000028_gene2733	6.083e-135	444.0	COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2TSSE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Malonyl-CoA decarboxylase	mcd	-	4.1.1.9	ko:K01578	ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152	-	R00233	RC00040	ko00000,ko00001,ko01000	-	-	-	MCD,MCD_N
CMS2_k127_6024095_30	647113.Metok_0149	4.067e-35	141.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota,23QJ8@183939|Methanococci	183939|Methanococci	C	PFAM Pyruvate	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
CMS2_k127_6024095_11	69014.TK1129	8.913e-108	355.0	COG1013@1|root,arCOG01599@2157|Archaea,2XUSE@28890|Euryarchaeota,2436C@183968|Thermococci	183968|Thermococci	C	ferredoxin oxidoreductase, subunit beta	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
CMS2_k127_6024095_8	604354.TSIB_1471	8.005e-131	428.0	COG0674@1|root,arCOG01607@2157|Archaea,2XW4W@28890|Euryarchaeota,2434K@183968|Thermococci	183968|Thermococci	C	ferredoxin oxidoreductase, subunit alpha	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
CMS2_k127_6024095_36	1220534.B655_0440	1.362e-19	89.0	COG1146@1|root,arCOG00959@2157|Archaea,2XZY3@28890|Euryarchaeota,23P9V@183925|Methanobacteria	183925|Methanobacteria	C	4Fe-4S dicluster domain	korD	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
CMS2_k127_6024095_9	880072.Desac_1740	2.266e-128	422.0	COG2865@1|root,COG2865@2|Bacteria,1R4MD@1224|Proteobacteria,42RP5@68525|delta/epsilon subdivisions,2WNV2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
CMS2_k127_6024095_29	203124.Tery_2760	2.765e-35	151.0	COG4249@1|root,COG4249@2|Bacteria,1GPWG@1117|Cyanobacteria,1HBAE@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
CMS2_k127_6024095_21	385682.AFSL01000047_gene519	6.916e-60	220.0	COG2972@1|root,COG2972@2|Bacteria,4NFDP@976|Bacteroidetes,2FPUC@200643|Bacteroidia,3XJG9@558415|Marinilabiliaceae	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
CMS2_k127_6024095_17	1235803.C825_02910	8.032e-84	285.0	COG3279@1|root,COG3279@2|Bacteria,4NGBF@976|Bacteroidetes,2FMKB@200643|Bacteroidia,22YB3@171551|Porphyromonadaceae	976|Bacteroidetes	KT	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
CMS2_k127_6024095_28	1304885.AUEY01000027_gene2338	1.225e-42	173.0	COG1538@1|root,COG1538@2|Bacteria,1MWX5@1224|Proteobacteria,42S0Z@68525|delta/epsilon subdivisions,2X5KP@28221|Deltaproteobacteria,2MPFG@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_6024095_16	452637.Oter_0322	4.26e-88	302.0	COG0845@1|root,COG0845@2|Bacteria,46TJP@74201|Verrucomicrobia,3K7D1@414999|Opitutae	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS2_k127_6024095_18	2074.JNYD01000034_gene6443	1.153e-73	254.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4DXK6@85010|Pseudonocardiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_6024095_15	452637.Oter_0320	6.002e-90	311.0	COG0577@1|root,COG0577@2|Bacteria,46U7K@74201|Verrucomicrobia,3K7M9@414999|Opitutae	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS2_k127_6024095_14	706587.Desti_0458	9.108e-94	325.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WM4S@28221|Deltaproteobacteria,2MRK9@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_6024095_32	1433126.BN938_2553	1.974e-27	124.0	2CI0I@1|root,332G0@2|Bacteria,4NXY5@976|Bacteroidetes,2FS6D@200643|Bacteroidia	976|Bacteroidetes	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
CMS2_k127_6024095_26	338966.Ppro_3386	8.12e-43	162.0	2E4AB@1|root,32Z61@2|Bacteria,1N9UX@1224|Proteobacteria,42UQD@68525|delta/epsilon subdivisions	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6024095_27	391623.TERMP_02111	9.66e-43	159.0	COG1487@1|root,arCOG02225@2157|Archaea,2Y4PV@28890|Euryarchaeota,244FX@183968|Thermococci	183968|Thermococci	V	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_6065160_4	304371.MCP_0885	3.348e-38	157.0	COG0535@1|root,arCOG00938@2157|Archaea	2157|Archaea	P	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
CMS2_k127_6065160_2	944564.HMPREF9200_0692	1.546e-95	334.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4H20M@909932|Negativicutes	909932|Negativicutes	V	lipid A export permease ATP-binding protein MsbA	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
CMS2_k127_6065160_3	290315.Clim_1913	5.605e-47	183.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS2_k127_6065160_0	1047013.AQSP01000095_gene2303	1.491e-186	610.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_6065160_6	1120965.AUBV01000003_gene418	5.259e-37	153.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2,Methyltransf_11,Methyltransf_25,Methyltransf_31
CMS2_k127_6065160_7	1116472.MGMO_94c00100	4.679e-36	146.0	COG3510@1|root,COG3510@2|Bacteria,1MWJ8@1224|Proteobacteria,1RY5R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Cephalosporin hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	CmcI
CMS2_k127_6065160_8	1541065.JRFE01000023_gene3778	8.852e-36	147.0	2E63H@1|root,330SK@2|Bacteria,1G9PE@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
CMS2_k127_6065160_5	452637.Oter_2772	4.321e-37	144.0	COG0110@1|root,COG0110@2|Bacteria,46WGB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	WxcM-like, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	FdtA
CMS2_k127_6065160_1	748280.NH8B_3544	1.376e-134	439.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,2KPVW@206351|Neisseriales	206351|Neisseriales	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_6065160_9	1137269.AZWL01000001_gene6008	7.168e-16	89.0	COG2362@1|root,COG2362@2|Bacteria,2GK6A@201174|Actinobacteria	201174|Actinobacteria	E	D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
CMS2_k127_6065160_10	123214.PERMA_0869	1.042e-14	85.0	COG0564@1|root,COG0564@2|Bacteria,2G44V@200783|Aquificae	200783|Aquificae	J	Belongs to the pseudouridine synthase RluA family	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS2_k127_6065160_12	1158338.JNLJ01000001_gene205	3.244e-13	83.0	28J7E@1|root,2Z92U@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
CMS2_k127_6078192_7	1123376.AUIU01000011_gene877	3.054e-29	138.0	COG0476@1|root,COG0476@2|Bacteria	2|Bacteria	H	Involved in molybdopterin and thiamine biosynthesis, family 2	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
CMS2_k127_6078192_4	394503.Ccel_2386	2.534e-235	786.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6078192_2	1042163.BRLA_c025640	0.0	1866.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_6078192_8	398767.Glov_0219	1.053e-05	49.0	2DG4U@1|root,2ZUHZ@2|Bacteria,1P7P1@1224|Proteobacteria,432VB@68525|delta/epsilon subdivisions,2WXHT@28221|Deltaproteobacteria,43VWC@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6078192_6	509191.AEDB02000067_gene916	7.409e-173	559.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_6078192_1	697284.ERIC2_c18050	0.0	1993.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6078192_0	1384066.JAGT01000001_gene577	0.0	2493.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyltransferase,Condensation,NAD_binding_4,PP-binding
CMS2_k127_6078192_5	509191.AEDB02000067_gene916	1.459e-190	612.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_6078192_3	1196323.ALKF01000118_gene5031	0.0	1427.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15667	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_6096802_16	469596.HMPREF9488_02037	2.508e-22	97.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,3VRNH@526524|Erysipelotrichia	526524|Erysipelotrichia	K	Cold-shock DNA-binding domain protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CMS2_k127_6096802_7	1047013.AQSP01000140_gene2504	1.39e-160	510.0	COG0863@1|root,COG2189@1|root,COG0863@2|Bacteria,COG2189@2|Bacteria,2NNU4@2323|unclassified Bacteria	2|Bacteria	L	DNA methylase	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590,ko:K07319	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
CMS2_k127_6096802_3	313606.M23134_06215	0.0	1133.0	COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,47KZ5@768503|Cytophagia	976|Bacteroidetes	G	PFAM Glycosyl Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_92
CMS2_k127_6096802_17	879212.DespoDRAFT_01195	1.226e-21	97.0	COG2865@1|root,COG2865@2|Bacteria,1R4MD@1224|Proteobacteria,42PSY@68525|delta/epsilon subdivisions,2WKXP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM Divergent AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2,HATPase_c_4
CMS2_k127_6096802_22	1499967.BAYZ01000100_gene3454	2.484e-15	78.0	2EVWS@1|root,33PAF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6096802_8	324925.Ppha_1108	8.249e-138	448.0	COG1162@1|root,COG1162@2|Bacteria,1FEWT@1090|Chlorobi	1090|Chlorobi	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	-	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
CMS2_k127_6096802_26	2850.Phatr49426	1.266e-08	61.0	2D0BY@1|root,2SDKM@2759|Eukaryota,2XB8I@2836|Bacillariophyta	2836|Bacillariophyta	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_4
CMS2_k127_6096802_18	572479.Hprae_1158	6.917e-19	94.0	2DS8H@1|root,32USH@2|Bacteria,1W2Z8@1239|Firmicutes	1239|Firmicutes	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
CMS2_k127_6096802_13	1167006.UWK_01483	1.207e-30	132.0	COG0593@1|root,COG1943@1|root,COG0593@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42RDM@68525|delta/epsilon subdivisions,2WMYM@28221|Deltaproteobacteria,2MJHP@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Bacterial dnaA protein helix-turn-helix	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Bac_DnaA_C,Y1_Tnp
CMS2_k127_6096802_23	870187.Thini_4071	9.321e-15	76.0	2DTYB@1|root,33N7I@2|Bacteria,1P64S@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2281
CMS2_k127_6096802_14	1499967.BAYZ01000153_gene1547	1.494e-29	122.0	COG1487@1|root,COG1487@2|Bacteria,2NS1P@2323|unclassified Bacteria	2|Bacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_6096802_15	641107.CDLVIII_2109	2.949e-25	107.0	COG1106@1|root,COG1106@2|Bacteria,1TSBY@1239|Firmicutes,249DS@186801|Clostridia,36IW4@31979|Clostridiaceae	186801|Clostridia	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K06926	-	-	-	-	ko00000	-	-	-	AAA_21
CMS2_k127_6096802_24	1408323.JQKK01000033_gene1253	1.512e-10	68.0	COG1669@1|root,COG1669@2|Bacteria,1UPJ6@1239|Firmicutes,25HHX@186801|Clostridia,27Q34@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CMS2_k127_6096802_6	1121904.ARBP01000015_gene179	9.98e-193	628.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47NTJ@768503|Cytophagia	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_6096802_2	1087481.AGFX01000046_gene2041	0.0	1888.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_6096802_21	512565.AMIS_39750	1.068e-15	83.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,4DH2J@85008|Micromonosporales	201174|Actinobacteria	GT	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
CMS2_k127_6096802_12	1324957.K933_06862	1.35e-54	202.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,23T1I@183963|Halobacteria	183963|Halobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS2_k127_6096802_9	395493.BegalDRAFT_0761	6.143e-131	431.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,45ZXR@72273|Thiotrichales	1236|Gammaproteobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS2_k127_6096802_19	102125.Xen7305DRAFT_00052260	1.499e-18	89.0	COG0236@1|root,COG0236@2|Bacteria,1GFQ6@1117|Cyanobacteria	1117|Cyanobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
CMS2_k127_6096802_10	102125.Xen7305DRAFT_00037270	8.203e-103	351.0	COG0318@1|root,COG0318@2|Bacteria,1G2H0@1117|Cyanobacteria,3VJHN@52604|Pleurocapsales	1117|Cyanobacteria	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
CMS2_k127_6096802_11	378806.STAUR_8030	7.835e-79	273.0	COG4424@1|root,COG4424@2|Bacteria,1RGI6@1224|Proteobacteria,42W1T@68525|delta/epsilon subdivisions,2WRRH@28221|Deltaproteobacteria,2YWVM@29|Myxococcales	28221|Deltaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
CMS2_k127_6096802_27	1410666.JHXG01000003_gene1196	0.0001861	53.0	COG3250@1|root,COG3507@1|root,COG3250@2|Bacteria,COG3507@2|Bacteria,4NIBS@976|Bacteroidetes,2FPZ2@200643|Bacteroidia	976|Bacteroidetes	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
CMS2_k127_6096802_1	755731.Clo1100_0890	0.0	2097.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6096802_5	768706.Desor_3736	2.192e-193	636.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,260Y0@186807|Peptococcaceae	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	ko:K15664	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_6096802_0	697284.ERIC2_c18050	0.0	2260.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6096802_4	1009370.ALO_00935	6.499e-197	638.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_6099211_1	1408422.JHYF01000017_gene1871	2.459e-190	634.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_6099211_0	1167006.UWK_01819	0.0	1019.0	COG0031@1|root,COG0215@1|root,COG0031@2|Bacteria,COG0215@2|Bacteria,1MUBE@1224|Proteobacteria,42M6M@68525|delta/epsilon subdivisions,2WIQM@28221|Deltaproteobacteria,2MIN1@213118|Desulfobacterales	28221|Deltaproteobacteria	J	cysteinyl-tRNA synthetase	cysM	-	2.5.1.47,6.1.1.16	ko:K01738,ko:K01883,ko:K12339	ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00359,M00360	R00897,R03132,R03601,R03650,R04859	RC00020,RC00055,RC00523,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,PALP,tRNA-synt_1e
CMS2_k127_6099211_4	1122216.AUHW01000001_gene652	2.489e-12	71.0	COG0375@1|root,COG0375@2|Bacteria,1VEP0@1239|Firmicutes,4H581@909932|Negativicutes	909932|Negativicutes	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
CMS2_k127_6099211_3	1121374.KB891576_gene331	1.43e-65	233.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1T4K6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	ppkA	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase,PEGA,Pkinase
CMS2_k127_6099211_2	1158338.JNLJ01000001_gene1004	2.279e-119	397.0	COG0068@1|root,COG0068@2|Bacteria,2G3JK@200783|Aquificae	200783|Aquificae	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
CMS2_k127_6101167_17	857087.Metme_0595	9.057e-12	67.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1XFDE@135618|Methylococcales	135618|Methylococcales	L	PFAM RNA-directed DNA polymerase (reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
CMS2_k127_6101167_10	1047013.AQSP01000114_gene684	1.941e-55	196.0	COG1629@1|root,COG2304@1|root,COG1629@2|Bacteria,COG2304@2|Bacteria,2NQ3W@2323|unclassified Bacteria	2|Bacteria	P	von Willebrand factor type A domain	yfbK	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	CarbopepD_reg_2,DUF3520,Plug,VWA,vWF_A
CMS2_k127_6101167_16	1033810.HLPCO_001920	8.699e-14	72.0	COG2304@1|root,COG2304@2|Bacteria,2NQ3W@2323|unclassified Bacteria	2|Bacteria	P	von Willebrand factor type A domain	yfbK	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	CarbopepD_reg_2,DUF3520,Plug,VWA,vWF_A
CMS2_k127_6101167_14	1047013.AQSP01000114_gene684	1.148e-28	117.0	COG1629@1|root,COG2304@1|root,COG1629@2|Bacteria,COG2304@2|Bacteria,2NQ3W@2323|unclassified Bacteria	2|Bacteria	P	von Willebrand factor type A domain	yfbK	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	CarbopepD_reg_2,DUF3520,Plug,VWA,vWF_A
CMS2_k127_6101167_0	880073.Calab_2455	0.0	1048.0	COG0243@1|root,COG0243@2|Bacteria,2NPRJ@2323|unclassified Bacteria	2|Bacteria	C	Molydopterin dinucleotide binding domain	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS2_k127_6101167_7	452637.Oter_1465	5.216e-78	264.0	COG0437@1|root,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	nrfC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044464,GO:0055114,GO:0098809	-	ko:K04014,ko:K08353,ko:K08358,ko:K16293	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10149,R10150	RC02823,RC03109	ko00000,ko00001,ko02000	5.A.3.10,5.A.3.5	-	iUMNK88_1353.UMNK88_4933	Fer4,Fer4_11,Fer4_3,Fer4_4
CMS2_k127_6101167_6	313603.FB2170_11546	6.234e-80	277.0	COG3301@1|root,COG3301@2|Bacteria,4NITJ@976|Bacteroidetes,1I0XA@117743|Flavobacteriia	976|Bacteroidetes	P	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
CMS2_k127_6101167_11	945713.IALB_1660	8.823e-53	197.0	COG2391@1|root,COG2391@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
CMS2_k127_6101167_9	880073.Calab_2451	2.331e-59	211.0	COG2391@1|root,COG2391@2|Bacteria,2NRQM@2323|unclassified Bacteria	2|Bacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Rhodanese,Sulf_transp
CMS2_k127_6101167_13	880073.Calab_2450	2.451e-30	128.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	2.8.1.1,2.8.1.2	ko:K00406,ko:K01011	ko00190,ko00270,ko00920,ko01100,ko01120,ko02020,ko04122,map00190,map00270,map00920,map01100,map01120,map02020,map04122	M00156	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cytochrome_CBB3,PALP,Rhodanese
CMS2_k127_6101167_12	880073.Calab_2461	7.278e-32	130.0	COG0789@1|root,COG0789@2|Bacteria,2NPTR@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulator, MerR family	-	-	2.1.1.37	ko:K00558,ko:K13639,ko:K13640	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03000,ko03032,ko03036	-	-	-	DNA_methylase,MerR,MerR_1
CMS2_k127_6101167_3	1353529.M899_1464	1.685e-103	347.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2MT16@213481|Bdellovibrionales,2WIWE@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS2_k127_6101167_2	439235.Dalk_0237	1.053e-105	383.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_6101167_15	400682.PAC_15713273	3.142e-22	111.0	COG0666@1|root,KOG1734@1|root,KOG0504@2759|Eukaryota,KOG1734@2759|Eukaryota,KOG4177@2759|Eukaryota,38C53@33154|Opisthokonta	33154|Opisthokonta	P	phosphoric diester hydrolase activity	PHO81	GO:0001932,GO:0001933,GO:0003674,GO:0004857,GO:0004860,GO:0004861,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0006469,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0012505,GO:0016020,GO:0016538,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019887,GO:0030234,GO:0030291,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0042325,GO:0042326,GO:0043086,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043549,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045859,GO:0045936,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071900,GO:0071901,GO:0071944,GO:0080090,GO:0098772	-	ko:K06653,ko:K15503	ko04111,map04111	-	-	-	ko00000,ko00001,ko01009,ko03400	-	-	-	Ank_2,Ank_4,GDPD,SPX
CMS2_k127_6101167_1	1499967.BAYZ01000076_gene816	1.938e-162	517.0	COG1064@1|root,COG1064@2|Bacteria,2NP06@2323|unclassified Bacteria	2|Bacteria	S	Alcohol dehydrogenase GroES-like domain	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS2_k127_6101167_4	1123274.KB899424_gene2978	7.741e-91	308.0	COG0719@1|root,COG0719@2|Bacteria,2J9G4@203691|Spirochaetes	203691|Spirochaetes	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K07033	-	-	-	-	ko00000	-	-	-	UPF0051
CMS2_k127_6101167_5	744872.Spica_0153	3.793e-88	297.0	COG0396@1|root,COG0396@2|Bacteria,2J8PI@203691|Spirochaetes	203691|Spirochaetes	O	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
CMS2_k127_6101167_19	469618.FVAG_00760	0.0009163	43.0	COG1694@1|root,COG1694@2|Bacteria,37CSV@32066|Fusobacteria	32066|Fusobacteria	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
CMS2_k127_6101167_8	1499967.BAYZ01000027_gene1768	2.05e-67	237.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,2NR8B@2323|unclassified Bacteria	2|Bacteria	T	NACHT domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,NACHT,NPCBM,PEGA,Pkinase
CMS2_k127_6101896_2	70601.3257956	7.939e-81	284.0	COG0430@1|root,arCOG04125@2157|Archaea,2XT7I@28890|Euryarchaeota,2438J@183968|Thermococci	183968|Thermococci	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.5	ko:K18105	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
CMS2_k127_6101896_1	1499967.BAYZ01000154_gene1533	5.081e-99	329.0	COG0084@1|root,COG0084@2|Bacteria,2NP9H@2323|unclassified Bacteria	2|Bacteria	L	TatD related DNase	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
CMS2_k127_6101896_0	1047013.AQSP01000105_gene1438	2.867e-139	447.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
CMS2_k127_6101896_3	1121403.AUCV01000073_gene1306	4.836e-10	67.0	COG1345@1|root,COG1572@1|root,COG1345@2|Bacteria,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	ko:K02396,ko:K13276	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02035,ko03110	-	-	-	Flg_bbr_C,Peptidase_S8,TMP_2,VCBS
CMS2_k127_6113765_0	588581.Cpap_0079	5.195e-272	866.0	COG2227@1|root,COG2230@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG2230@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_6117135_9	1034807.FBFL15_2074	1.132e-09	60.0	COG5464@1|root,COG5464@2|Bacteria,4NJT2@976|Bacteroidetes,1IDMC@117743|Flavobacteriia,2NYR8@237|Flavobacterium	976|Bacteroidetes	S	to proteins from other organisms	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_6117135_0	998674.ATTE01000001_gene1932	2.383e-212	676.0	COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,1RP5Z@1236|Gammaproteobacteria,463WQ@72273|Thiotrichales	72273|Thiotrichales	E	Fumarase C C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	FumaraseC_C,Lyase_1,cNMP_binding
CMS2_k127_6117135_7	338963.Pcar_0905	2.27e-24	104.0	COG3530@1|root,COG3530@2|Bacteria,1N7GT@1224|Proteobacteria,42V3W@68525|delta/epsilon subdivisions,2WREM@28221|Deltaproteobacteria,43SRY@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Putative quorum-sensing-regulated virulence factor	-	-	-	ko:K09954	-	-	-	-	ko00000	-	-	-	QSregVF_b
CMS2_k127_6117135_4	1521187.JPIM01000139_gene2219	3.933e-43	169.0	COG0697@1|root,COG0697@2|Bacteria,2G7RS@200795|Chloroflexi,377VC@32061|Chloroflexia	32061|Chloroflexia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS2_k127_6117135_1	1444711.CCJF01000005_gene970	5.39e-185	591.0	COG0442@1|root,COG0442@2|Bacteria,2JFHZ@204428|Chlamydiae	204428|Chlamydiae	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
CMS2_k127_6117135_5	744872.Spica_0889	7.344e-42	156.0	COG1373@1|root,COG1373@2|Bacteria,2J6SC@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_6117135_6	4565.Traes_1DS_82D0EC12B.2	6.232e-37	163.0	COG4886@1|root,2QQYD@2759|Eukaryota,37P0C@33090|Viridiplantae,3G8IW@35493|Streptophyta,3KXH1@4447|Liliopsida,3INV2@38820|Poales	35493|Streptophyta	T	Leucine Rich Repeat	-	-	-	-	-	-	-	-	-	-	-	-	LRRNT_2,LRR_1,LRR_4,LRR_8,Pkinase,Pkinase_Tyr
CMS2_k127_6117135_3	1191523.MROS_2005	1.593e-66	261.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6117135_2	247490.KSU1_C0714	1e-123	445.0	COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes	203682|Planctomycetes	O	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
CMS2_k127_6117135_8	1219049.SP5_072_00180	1.412e-11	76.0	2DDNF@1|root,2ZIP8@2|Bacteria,1P069@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6121329_42	1454007.JAUG01000013_gene2403	1.889e-09	65.0	2EBYR@1|root,335Y1@2|Bacteria,4P40B@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6121329_34	760192.Halhy_0899	1.641e-27	117.0	COG5464@1|root,COG5464@2|Bacteria,4NGSI@976|Bacteroidetes	976|Bacteroidetes	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_6121329_23	62928.azo3774	1.076e-62	237.0	COG0515@1|root,COG0515@2|Bacteria,1P64D@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	pkn9	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_6121329_41	713586.KB900536_gene506	6.855e-11	72.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_3,PAS_4,PAS_9,dCache_1
CMS2_k127_6121329_44	685727.REQ_00290	9.213e-06	52.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4FX2I@85025|Nocardiaceae	201174|Actinobacteria	T	Protein of unknown function (DUF2662)	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
CMS2_k127_6121329_29	935948.KE386495_gene1777	5.22e-39	160.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,42EM8@68295|Thermoanaerobacterales	186801|Clostridia	T	protein phosphatase 2C domain protein	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
CMS2_k127_6121329_39	272562.CA_C0463	3.716e-12	79.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,36DM2@31979|Clostridiaceae	186801|Clostridia	O	PDZ DHR GLGF domain protein	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS2_k127_6121329_43	1089455.MOPEL_003_01390	9.202e-09	68.0	COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,2GKEU@201174|Actinobacteria,4F7C3@85018|Dermatophilaceae	201174|Actinobacteria	V	Forkhead associated domain	-	-	-	ko:K01990,ko:K21397	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC_tran,FHA,Yop-YscD_cpl
CMS2_k127_6121329_5	868131.MSWAN_1300	1.415e-123	417.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,23NX2@183925|Methanobacteria	183925|Methanobacteria	J	Phenylalanyl-tRNA synthetase beta	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
CMS2_k127_6121329_6	1220534.B655_1407	2.973e-117	394.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,23NUT@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
CMS2_k127_6121329_37	1379281.AVAG01000029_gene12	2.916e-16	85.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,2M8MD@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Type II and III secretion system protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
CMS2_k127_6121329_21	178306.PAE3500	1.767e-65	231.0	COG0846@1|root,arCOG04248@2157|Archaea,2XQBQ@28889|Crenarchaeota	28889|Crenarchaeota	K	form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
CMS2_k127_6121329_2	1232437.KL661969_gene4962	2.282e-223	703.0	COG1231@1|root,COG1231@2|Bacteria,1MV82@1224|Proteobacteria	1224|Proteobacteria	E	amine oxidase	iaaM	-	1.13.12.3	ko:K00466	ko00380,map00380	-	R00679	RC00213	ko00000,ko00001,ko01000	-	-	iJN746.PP_0383	Amino_oxidase
CMS2_k127_6121329_26	243231.GSU1489	6.429e-49	198.0	COG1807@1|root,COG1807@2|Bacteria,1N8ZV@1224|Proteobacteria,42WB6@68525|delta/epsilon subdivisions,2WRTT@28221|Deltaproteobacteria,43TNH@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723
CMS2_k127_6121329_25	349521.HCH_04438	6.486e-54	199.0	COG0596@1|root,COG0596@2|Bacteria,1NCX0@1224|Proteobacteria,1S8EB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS2_k127_6121329_24	391625.PPSIR1_17725	2.796e-56	206.0	COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria,43B0B@68525|delta/epsilon subdivisions,2X6EF@28221|Deltaproteobacteria,2Z3AR@29|Myxococcales	28221|Deltaproteobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS2_k127_6121329_32	765912.Thimo_0258	2.334e-29	124.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_6121329_1	765912.Thimo_0246	1.611e-261	814.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales	135613|Chromatiales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CMS2_k127_6121329_17	1049564.TevJSym_az00340	8.536e-94	313.0	COG1018@1|root,COG1152@1|root,COG1018@2|Bacteria,COG1152@2|Bacteria,1R9TR@1224|Proteobacteria,1SJQC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_9
CMS2_k127_6121329_8	765912.Thimo_0257	1.382e-115	377.0	COG0543@1|root,COG0543@2|Bacteria,1MV72@1224|Proteobacteria,1T4D8@1236|Gammaproteobacteria,1X2TA@135613|Chromatiales	135613|Chromatiales	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
CMS2_k127_6121329_10	1049564.TevJSym_az00220	1.352e-107	359.0	COG0479@1|root,COG0479@2|Bacteria,1QVWG@1224|Proteobacteria,1RNMQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S dicluster domain	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
CMS2_k127_6121329_9	765912.Thimo_0255	2.219e-113	376.0	COG1035@1|root,COG4656@1|root,COG1035@2|Bacteria,COG4656@2|Bacteria,1NQN7@1224|Proteobacteria,1SM0M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus	-	-	-	-	-	-	-	-	-	-	-	-	FrhB_FdhB_C
CMS2_k127_6121329_22	765912.Thimo_0254	6.289e-64	222.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,1SPUH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
CMS2_k127_6121329_0	1049564.TevJSym_az00260	3.688e-307	953.0	COG1148@1|root,COG1148@2|Bacteria,1R882@1224|Proteobacteria,1SAD3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
CMS2_k127_6121329_18	1049564.TevJSym_az00270	1.007e-74	254.0	COG1014@1|root,COG1014@2|Bacteria,1RAA8@1224|Proteobacteria,1SK9E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
CMS2_k127_6121329_4	1049564.TevJSym_az00280	3.643e-135	435.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1J5GQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
CMS2_k127_6121329_3	1049564.TevJSym_az00290	1.511e-185	586.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
CMS2_k127_6121329_33	1049564.TevJSym_az00300	2.069e-28	117.0	COG1146@1|root,COG1146@2|Bacteria,1N0QV@1224|Proteobacteria,1SQ9V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	-
CMS2_k127_6121329_7	765912.Thimo_0248	1.435e-116	381.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria,1X060@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
CMS2_k127_6121329_28	765912.Thimo_0247	1.823e-46	171.0	COG1150@1|root,COG1150@2|Bacteria,1R874@1224|Proteobacteria,1SHQ0@1236|Gammaproteobacteria,1WZZ0@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K16887	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
CMS2_k127_6121329_38	880072.Desac_2839	1.209e-14	77.0	COG3041@1|root,COG3041@2|Bacteria,1NBQC@1224|Proteobacteria,42VGK@68525|delta/epsilon subdivisions,2WS63@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Addiction module toxin RelE StbE family	-	-	-	-	-	-	-	-	-	-	-	-	YafQ_toxin
CMS2_k127_6121329_16	1499967.BAYZ01000080_gene917	5.628e-94	323.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_6121329_14	1499967.BAYZ01000080_gene917	8.092e-96	329.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_6121329_45	421072.IO89_08480	9.724e-05	54.0	COG1994@1|root,COG1994@2|Bacteria,4NTBD@976|Bacteroidetes,1I1XZ@117743|Flavobacteriia	976|Bacteroidetes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	-
CMS2_k127_6121329_36	37659.JNLN01000001_gene2349	5.941e-18	96.0	COG0476@1|root,COG0476@2|Bacteria,1W1S7@1239|Firmicutes,24XC6@186801|Clostridia,36P7H@31979|Clostridiaceae	186801|Clostridia	H	PFAM UBA THIF-type NAD FAD binding	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
CMS2_k127_6121329_27	215803.DB30_8309	5.089e-48	190.0	COG1944@1|root,COG1944@2|Bacteria,1PYVK@1224|Proteobacteria,434I6@68525|delta/epsilon subdivisions,2X8WN@28221|Deltaproteobacteria,2Z0QS@29|Myxococcales	28221|Deltaproteobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
CMS2_k127_6121329_30	268407.PWYN_10910	2.749e-34	143.0	COG0778@1|root,COG0778@2|Bacteria,1UWU9@1239|Firmicutes,4H9ZQ@91061|Bacilli,26UIF@186822|Paenibacillaceae	91061|Bacilli	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS2_k127_6121329_20	1231057.AMGD01000002_gene2388	5.939e-72	253.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,4HA8K@91061|Bacilli,26IJ5@186818|Planococcaceae	91061|Bacilli	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K11050	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC_tran
CMS2_k127_6121329_35	1307436.PBF_00055	4.15e-24	111.0	COG0842@1|root,COG0842@2|Bacteria,1V7QG@1239|Firmicutes,4HFU4@91061|Bacilli,1ZD2I@1386|Bacillus	91061|Bacilli	V	COG0842 ABC-type multidrug transport system, permease component	XK27_09830	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
CMS2_k127_6121329_12	1499967.BAYZ01000080_gene917	7.087e-98	335.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_6121329_13	1499967.BAYZ01000080_gene917	2.315e-97	332.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_6121329_15	1499967.BAYZ01000080_gene917	2.571e-95	327.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_6121329_40	1249627.D779_1291	4.207e-11	72.0	28MUS@1|root,2ZB2I@2|Bacteria,1N8T7@1224|Proteobacteria,1RZI3@1236|Gammaproteobacteria,1WXS4@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4412)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4412
CMS2_k127_6121329_31	189426.PODO_07785	5.643e-32	138.0	COG0614@1|root,COG3735@1|root,COG0614@2|Bacteria,COG3735@2|Bacteria,1V9SQ@1239|Firmicutes,4IRRK@91061|Bacilli,276WD@186822|Paenibacillaceae	91061|Bacilli	L	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	Cu_amine_oxidN1,TraB
CMS2_k127_6121329_11	1499967.BAYZ01000080_gene917	9.22e-105	355.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_6121329_19	247490.KSU1_C0289	8.462e-74	274.0	COG1032@1|root,COG1032@2|Bacteria,2J1TE@203682|Planctomycetes	203682|Planctomycetes	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_6142435_0	489825.LYNGBM3L_68120	9.406e-205	670.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H9T8@1150|Oscillatoriales	1117|Cyanobacteria	Q	Amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_6142435_1	1007103.AFHW01000215_gene834	1.187e-137	458.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_614317_0	517417.Cpar_0695	1.164e-129	422.0	COG0841@1|root,COG0841@2|Bacteria,1FDHA@1090|Chlorobi	1090|Chlorobi	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS2_k127_614317_1	517417.Cpar_0696	1.152e-96	332.0	COG1538@1|root,COG1538@2|Bacteria,1FDFP@1090|Chlorobi	1090|Chlorobi	MU	PFAM outer membrane efflux protein	-	-	-	ko:K12340,ko:K12543	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00330,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2,3.A.1.109.4	-	-	OEP
CMS2_k127_6170698_1	1121396.KB893085_gene343	0.0	1655.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42Z5Y@68525|delta/epsilon subdivisions,2X8JI@28221|Deltaproteobacteria,2MMZD@213118|Desulfobacterales	1224|Proteobacteria	Q	Condensation domain	-	-	-	ko:K04786	ko01053,map01053	-	-	-	ko00000,ko00001,ko01004,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_6170698_0	349520.PPE_03011	0.0	2617.0	COG2227@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	pksR	-	-	ko:K13613,ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_617642_15	59374.Fisuc_0917	1.424e-19	94.0	COG4704@1|root,COG4704@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Fib_succ_major
CMS2_k127_617642_19	1235790.C805_00437	7.194e-07	59.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
CMS2_k127_617642_8	562970.Btus_0876	1.966e-64	229.0	COG1682@1|root,COG1682@2|Bacteria,1TY8I@1239|Firmicutes,4I47R@91061|Bacilli,279PC@186823|Alicyclobacillaceae	91061|Bacilli	P	PFAM ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
CMS2_k127_617642_2	1047013.AQSP01000144_gene865	1.065e-141	460.0	COG1134@1|root,COG1134@2|Bacteria,2NP4S@2323|unclassified Bacteria	2|Bacteria	GM	ATPases associated with a variety of cellular activities	-	-	3.6.3.38	ko:K01990,ko:K09689,ko:K09691	ko02010,map02010	M00249,M00250,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.101,3.A.1.103	-	-	ABC_tran,Wzt_C
CMS2_k127_617642_18	930945.SiRe_1801	1.833e-07	63.0	COG2835@1|root,arCOG04124@2157|Archaea,2XQTG@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
CMS2_k127_617642_16	1179773.BN6_47750	1.162e-16	92.0	COG0500@1|root,COG2226@2|Bacteria,2IEI0@201174|Actinobacteria,4E86U@85010|Pseudonocardiales	201174|Actinobacteria	Q	Domain of unknown function (DUF4214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,Methyltransf_11
CMS2_k127_617642_1	1047013.AQSP01000144_gene866	1.593e-153	508.0	COG0500@1|root,COG1216@1|root,COG1216@2|Bacteria,COG2226@2|Bacteria,2NPQ4@2323|unclassified Bacteria	2|Bacteria	J	Glycosyltransferase like family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
CMS2_k127_617642_5	1047013.AQSP01000144_gene866	9.473e-91	310.0	COG0500@1|root,COG1216@1|root,COG1216@2|Bacteria,COG2226@2|Bacteria,2NPQ4@2323|unclassified Bacteria	2|Bacteria	J	Glycosyltransferase like family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
CMS2_k127_617642_12	386456.JQKN01000003_gene397	2.319e-33	138.0	COG0500@1|root,arCOG01773@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
CMS2_k127_617642_6	221288.JH992901_gene5376	1.32e-76	272.0	COG0438@1|root,COG0438@2|Bacteria,1G3U9@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_617642_11	221288.JH992901_gene5376	5.633e-47	185.0	COG0438@1|root,COG0438@2|Bacteria,1G3U9@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_617642_14	1123518.ARWI01000001_gene864	1.252e-20	106.0	COG1216@1|root,COG1216@2|Bacteria,1R6SJ@1224|Proteobacteria,1RQQW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_617642_0	1121904.ARBP01000004_gene1051	2.117e-209	664.0	COG2304@1|root,COG2304@2|Bacteria,4NFX3@976|Bacteroidetes,47KQ9@768503|Cytophagia	976|Bacteroidetes	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	CarbopepD_reg_2,DUF3520,VWA,vWF_A
CMS2_k127_617642_3	1304885.AUEY01000104_gene2548	3.224e-127	413.0	COG0702@1|root,COG0702@2|Bacteria,1Q438@1224|Proteobacteria,439WM@68525|delta/epsilon subdivisions,2X29K@28221|Deltaproteobacteria,2MPBK@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
CMS2_k127_617642_4	631362.Thi970DRAFT_03451	1.031e-115	386.0	COG2865@1|root,COG2865@2|Bacteria,1MXG1@1224|Proteobacteria,1S1HY@1236|Gammaproteobacteria,1WZK1@135613|Chromatiales	135613|Chromatiales	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
CMS2_k127_617642_10	747365.Thena_0855	3.415e-50	190.0	COG4424@1|root,COG4424@2|Bacteria,1V5ZE@1239|Firmicutes,25053@186801|Clostridia	186801|Clostridia	S	PFAM Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
CMS2_k127_617642_13	429009.Adeg_1337	6.677e-28	115.0	COG1487@1|root,COG1487@2|Bacteria,1VKMK@1239|Firmicutes,25DTE@186801|Clostridia	186801|Clostridia	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
CMS2_k127_617642_17	429009.Adeg_1338	2.225e-13	72.0	2E3ZN@1|root,31DMU@2|Bacteria,1W63Y@1239|Firmicutes,256B4@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_617642_7	1343740.M271_10025	7.08e-67	254.0	2DB8U@1|root,2Z7SW@2|Bacteria,2IA41@201174|Actinobacteria	201174|Actinobacteria	S	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase
CMS2_k127_617642_9	794903.OPIT5_14895	2.229e-58	228.0	2DB8U@1|root,2Z7SW@2|Bacteria,46VFK@74201|Verrucomicrobia,3KA1F@414999|Opitutae	74201|Verrucomicrobia	M	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase
CMS2_k127_6198458_0	880071.Fleli_4087	0.0	1133.0	COG0515@1|root,COG2203@1|root,COG2208@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3899@2|Bacteria,4PM99@976|Bacteroidetes,47KKS@768503|Cytophagia	976|Bacteroidetes	KLT	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,Pkinase,SpoIIE
CMS2_k127_6198458_4	313606.M23134_04734	5.659e-31	141.0	COG0457@1|root,COG2208@1|root,COG3064@1|root,COG0457@2|Bacteria,COG2208@2|Bacteria,COG3064@2|Bacteria,4PI8Y@976|Bacteroidetes,47TST@768503|Cytophagia	2|Bacteria	KT	Sigma factor PP2C-like phosphatases	tolA	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HAMP,SpoIIE,TPR_12,TPR_8,TolA,Y_Y_Y
CMS2_k127_6198458_3	1123250.KB908381_gene1708	5.548e-49	199.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H2BH@909932|Negativicutes	909932|Negativicutes	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_6198458_2	1121422.AUMW01000005_gene670	2.532e-80	278.0	COG1149@1|root,COG1149@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	ldpA	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,LdpA_C
CMS2_k127_6198458_1	880073.Calab_3515	1.611e-206	658.0	COG0471@1|root,COG0471@2|Bacteria	2|Bacteria	P	metal ion transport	sac1	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	CitMHS,Na_sulph_symp,TrkA_C
CMS2_k127_6198458_5	46234.ANA_C11879	2.527e-14	73.0	COG5464@1|root,COG5464@2|Bacteria,1G211@1117|Cyanobacteria,1HS60@1161|Nostocales	1117|Cyanobacteria	S	PD-(D/E)XK nuclease family transposase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,PDDEXK_2
CMS2_k127_6198513_3	478749.BRYFOR_08234	2.411e-08	63.0	COG2207@1|root,COG2207@2|Bacteria,1UZ0N@1239|Firmicutes,24GNF@186801|Clostridia	186801|Clostridia	K	transcriptional regulator (AraC family)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS2_k127_6198513_0	1121930.AQXG01000002_gene2021	2.785e-37	147.0	COG1863@1|root,COG1863@2|Bacteria,4P6YY@976|Bacteroidetes	976|Bacteroidetes	P	Na+/H+ ion antiporter subunit	-	-	-	-	-	-	-	-	-	-	-	-	MNHE
CMS2_k127_6198513_1	1121930.AQXG01000002_gene2022	1.796e-24	104.0	COG2212@1|root,COG2212@2|Bacteria	2|Bacteria	P	antiporter activity	mnhF	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
CMS2_k127_6198513_2	1121930.AQXG01000002_gene2023	6.263e-19	89.0	COG1320@1|root,COG1320@2|Bacteria,4NWMX@976|Bacteroidetes,1IUP8@117747|Sphingobacteriia	976|Bacteroidetes	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
CMS2_k127_6199573_0	63737.Npun_R3027	0.0	2973.0	COG0001@1|root,COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0001@2|Bacteria,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1HIST@1161|Nostocales	1117|Cyanobacteria	Q	acyl transferase domain	-	-	-	ko:K16129	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Bac_luciferase,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,ketoacyl-synt
CMS2_k127_6199573_4	870187.Thini_1087	5.952e-55	209.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,4634K@72273|Thiotrichales	72273|Thiotrichales	S	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
CMS2_k127_6199573_3	472759.Nhal_0828	1.421e-68	254.0	COG0515@1|root,COG0515@2|Bacteria,1QXK0@1224|Proteobacteria,1T3DE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	Pkinase,TIR_2
CMS2_k127_6199573_2	526222.Desal_1387	8.09e-88	304.0	2C1K7@1|root,2ZA9X@2|Bacteria,1R95T@1224|Proteobacteria,42YB8@68525|delta/epsilon subdivisions,2WTWR@28221|Deltaproteobacteria,2MEUG@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6199573_6	945713.IALB_0674	0.000941	51.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128
CMS2_k127_6199573_1	439235.Dalk_0237	2.042e-118	403.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_6199573_5	215803.DB30_3970	4.961e-16	92.0	COG3266@1|root,COG3568@1|root,COG3266@2|Bacteria,COG3568@2|Bacteria,1N2ZJ@1224|Proteobacteria,42WUR@68525|delta/epsilon subdivisions,2WSUA@28221|Deltaproteobacteria,2YUA6@29|Myxococcales	28221|Deltaproteobacteria	PQ	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,LTD
CMS2_k127_6204628_0	1121904.ARBP01000055_gene485	7.9e-206	691.0	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,47JBS@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_6204628_1	1168034.FH5T_07730	4.458e-124	424.0	COG0745@1|root,COG1879@1|root,COG5002@1|root,COG0745@2|Bacteria,COG1879@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,2FWSR@200643|Bacteroidia	976|Bacteroidetes	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Peripla_BP_4,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_6204628_2	1121104.AQXH01000001_gene1263	5.118e-101	364.0	COG0642@1|root,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes,1IQ4P@117747|Sphingobacteriia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,GAF,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,TPR_12
CMS2_k127_6211100_0	1009370.ALO_00920	1.239e-289	922.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	909932|Negativicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_6212650_21	1211844.CBLM010000082_gene1251	9.968e-05	53.0	COG1835@1|root,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,ABC2_membrane_5,Acyl_transf_3,DUF4153,HATPase_c,HisKA,His_kinase,Response_reg
CMS2_k127_6212650_22	634956.Geoth_3467	0.0005282	50.0	2DBCD@1|root,32TX7@2|Bacteria,1VC2X@1239|Firmicutes,4HSWG@91061|Bacilli	91061|Bacilli	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_5
CMS2_k127_6212650_6	332101.JIBU02000043_gene1498	7.976e-119	389.0	COG1131@1|root,COG1131@2|Bacteria,1TPZR@1239|Firmicutes,247NW@186801|Clostridia,36E9X@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_6212650_14	580331.Thit_2160	2.257e-44	166.0	COG1725@1|root,COG1725@2|Bacteria,1V9ZC@1239|Firmicutes,24NTW@186801|Clostridia,42H6M@68295|Thermoanaerobacterales	186801|Clostridia	K	PFAM regulatory protein GntR HTH	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS2_k127_6212650_17	1123278.KB893592_gene6006	2.954e-32	128.0	COG2442@1|root,COG2442@2|Bacteria,4P60R@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
CMS2_k127_6212650_16	65393.PCC7424_5309	2.465e-33	131.0	COG4634@1|root,COG4634@2|Bacteria,1G7XW@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6212650_19	484019.THA_1114	1.949e-22	107.0	COG0561@1|root,COG0561@2|Bacteria,2GCXW@200918|Thermotogae	200918|Thermotogae	S	HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
CMS2_k127_6212650_15	1283300.ATXB01000001_gene979	1.082e-35	143.0	COG1132@1|root,COG1132@2|Bacteria,1QXPT@1224|Proteobacteria,1T3FA@1236|Gammaproteobacteria,1XF1H@135618|Methylococcales	135618|Methylococcales	V	ABC transporter	-	-	-	ko:K02068	-	M00211	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
CMS2_k127_6212650_11	525897.Dbac_3073	3.379e-69	244.0	COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,42RYA@68525|delta/epsilon subdivisions,2WNM0@28221|Deltaproteobacteria,2MGBU@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Uncharacterised protein family (UPF0014)	-	-	-	ko:K02069	-	M00211	-	-	ko00000,ko00002,ko02000	9.B.25.1	-	-	UPF0014
CMS2_k127_6212650_3	1499967.BAYZ01000119_gene3216	5.482e-159	520.0	COG0574@1|root,COG0574@2|Bacteria,2NQHP@2323|unclassified Bacteria	2|Bacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_2,PPDK_N,Response_reg
CMS2_k127_6212650_8	1499967.BAYZ01000119_gene3214	1.461e-90	306.0	COG2129@1|root,COG2129@2|Bacteria	2|Bacteria	L	metallophosphoesterase	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2,Metallophos_3
CMS2_k127_6212650_12	706434.HMPREF9429_01799	2.189e-56	209.0	COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,4H3GS@909932|Negativicutes	909932|Negativicutes	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
CMS2_k127_6212650_2	1047013.AQSP01000119_gene1293	3.668e-207	662.0	COG1154@1|root,COG1154@2|Bacteria,2NNNA@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0008661,GO:0009058,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901363,GO:1901576,GO:1901681	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
CMS2_k127_6212650_9	323848.Nmul_A2092	6.793e-79	274.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,2VU4X@28216|Betaproteobacteria,372W6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Prolyl oligopeptidase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
CMS2_k127_6212650_13	382464.ABSI01000010_gene3740	2.186e-49	178.0	COG1725@1|root,COG1725@2|Bacteria	2|Bacteria	K	Transcriptional regulator	ytrA	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS2_k127_6212650_5	382464.ABSI01000010_gene3739	2.165e-123	402.0	COG0330@1|root,COG0330@2|Bacteria,46VDU@74201|Verrucomicrobia	74201|Verrucomicrobia	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS2_k127_6212650_1	518766.Rmar_0638	9.834e-284	877.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1FIMH@1100069|Bacteroidetes Order II. Incertae sedis	2|Bacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
CMS2_k127_6212650_20	518766.Rmar_0637	2.283e-21	98.0	2FDJV@1|root,345M5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6212650_10	1237149.C900_05795	1.256e-69	243.0	COG3208@1|root,COG3208@2|Bacteria,4NPE6@976|Bacteroidetes	976|Bacteroidetes	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioesterase
CMS2_k127_6212650_18	1121889.AUDM01000004_gene2567	2.754e-25	113.0	2B9NZ@1|root,3231D@2|Bacteria,4NR0T@976|Bacteroidetes,1I4J7@117743|Flavobacteriia,2NUTE@237|Flavobacterium	976|Bacteroidetes	S	Protein of unknown function (DUF1579)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1579
CMS2_k127_6212650_7	1047013.AQSP01000123_gene1522	5.985e-105	368.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_6212650_0	697284.ERIC2_c18040	0.0	1352.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6212650_4	1195236.CTER_1449	1.07e-143	518.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_6251636_1	7739.XP_002611185.1	2.761e-15	88.0	COG0457@1|root,KOG1840@2759|Eukaryota,38CFM@33154|Opisthokonta	33154|Opisthokonta	Z	microtubule motor activity	-	-	-	ko:K10407	ko05132,map05132	-	-	-	ko00000,ko00001,ko03019,ko04812	-	-	-	DUF294,TPR_10,TPR_12,TPR_7
CMS2_k127_6251636_0	944481.JAFP01000001_gene133	2.853e-21	95.0	COG1396@1|root,COG1396@2|Bacteria,1N31H@1224|Proteobacteria,42U1N@68525|delta/epsilon subdivisions,2WS5E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS2_k127_6259523_30	1499967.BAYZ01000088_gene5134	7.954e-59	218.0	COG1100@1|root,COG1100@2|Bacteria,2NPDD@2323|unclassified Bacteria	2|Bacteria	K	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	DUF697,MMR_HSR1
CMS2_k127_6259523_45	1408433.JHXV01000008_gene148	2.09e-27	117.0	COG0629@1|root,COG0629@2|Bacteria,4NQBK@976|Bacteroidetes,1I27K@117743|Flavobacteriia,2PB1R@246874|Cryomorphaceae	976|Bacteroidetes	L	TIGRFAM single stranded DNA-binding protein (ssb)	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
CMS2_k127_6259523_38	1047013.AQSP01000135_gene1611	2.973e-36	147.0	COG1729@1|root,COG1729@2|Bacteria,2NQ0B@2323|unclassified Bacteria	2|Bacteria	S	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,YfiO
CMS2_k127_6259523_35	1047013.AQSP01000135_gene1612	3.875e-50	183.0	COG2885@1|root,COG2885@2|Bacteria,2NPMV@2323|unclassified Bacteria	2|Bacteria	M	OmpA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
CMS2_k127_6259523_16	485913.Krac_4283	1.904e-116	380.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_6259523_1	1237149.C900_05793	1.075e-309	980.0	COG1680@1|root,COG4615@1|root,COG1680@2|Bacteria,COG4615@2|Bacteria,4NJ17@976|Bacteroidetes	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,Beta-lactamase
CMS2_k127_6259523_7	338963.Pcar_0144	5.986e-201	638.0	COG2268@1|root,COG2268@2|Bacteria,1PK3C@1224|Proteobacteria,43EP8@68525|delta/epsilon subdivisions,2X2JX@28221|Deltaproteobacteria,43VSU@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Flotillin	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
CMS2_k127_6259523_41	338963.Pcar_0143	5.176e-35	141.0	29X52@1|root,30IU1@2|Bacteria,1N8YP@1224|Proteobacteria,42WWU@68525|delta/epsilon subdivisions,2WT2G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6259523_46	573064.Mefer_1325	2.584e-27	124.0	COG0618@1|root,arCOG01566@2157|Archaea,2XT9H@28890|Euryarchaeota,23Q6S@183939|Methanococci	183939|Methanococci	S	phosphoesterase RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1,TrkA_N
CMS2_k127_6259523_5	1499967.BAYZ01000061_gene5977	5.891e-226	739.0	COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria,2NNZT@2323|unclassified Bacteria	2|Bacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,HisKA_2,PAS_9,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_6259523_24	1517682.HW49_10505	8.049e-89	311.0	COG0535@1|root,COG0535@2|Bacteria,4NMXM@976|Bacteroidetes,2FPWE@200643|Bacteroidia,230NK@171551|Porphyromonadaceae	976|Bacteroidetes	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS2_k127_6259523_11	1047013.AQSP01000123_gene1522	7.891e-150	500.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_6259523_2	1408473.JHXO01000008_gene2886	1.379e-303	954.0	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,2FS4M@200643|Bacteroidia	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_6259523_47	1379698.RBG1_1C00001G0964	2.632e-27	115.0	COG2050@1|root,COG2050@2|Bacteria,2NQ0Q@2323|unclassified Bacteria	2|Bacteria	Q	Thioesterase superfamily	-	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	4HBT
CMS2_k127_6259523_19	885272.JonanDRAFT_0213	3.602e-96	332.0	COG4690@1|root,COG4690@2|Bacteria,3TAQ3@508458|Synergistetes	508458|Synergistetes	M	Dipeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
CMS2_k127_6259523_20	1304284.L21TH_0538	7.116e-96	325.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes	1239|Firmicutes	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
CMS2_k127_6259523_34	518766.Rmar_2231	7.979e-51	192.0	COG3228@1|root,COG3228@2|Bacteria,4NGM9@976|Bacteroidetes,1FJ6P@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Glucose-regulated metallo-peptidase M90	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90,SEC-C
CMS2_k127_6259523_32	1158318.ATXC01000001_gene356	6.361e-53	195.0	COG1187@1|root,COG1187@2|Bacteria,2G3YU@200783|Aquificae	200783|Aquificae	J	Belongs to the pseudouridine synthase RsuA family	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS2_k127_6259523_13	1047013.AQSP01000083_gene1192	1.346e-127	422.0	COG2204@1|root,COG2204@2|Bacteria,2NNPN@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	nla19	-	-	ko:K07713,ko:K07714,ko:K19641	ko02020,map02020	M00499,M00500,M00772	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_6259523_12	1047013.AQSP01000083_gene1191	2.986e-132	455.0	COG4191@1|root,COG4191@2|Bacteria,2NPGF@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,GAF_3,HAMP,HATPase_c,HisKA,PAS,PAS_4
CMS2_k127_6259523_29	1107311.Q767_08845	6.049e-62	219.0	COG2518@1|root,COG2518@2|Bacteria,4NMTP@976|Bacteroidetes,1I1EU@117743|Flavobacteriia,2NYPM@237|Flavobacterium	976|Bacteroidetes	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CMS2_k127_6259523_48	1163408.UU9_07176	7.35e-27	115.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,1SDD5@1236|Gammaproteobacteria,1X6IQ@135614|Xanthomonadales	135614|Xanthomonadales	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
CMS2_k127_6259523_60	96561.Dole_1273	5.987e-11	75.0	COG0457@1|root,COG0457@2|Bacteria,1RKQQ@1224|Proteobacteria,42T9T@68525|delta/epsilon subdivisions,2WPQ0@28221|Deltaproteobacteria,2MN67@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_16,TPR_2,TPR_8
CMS2_k127_6259523_44	404380.Gbem_0907	1.266e-30	136.0	COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,42U2R@68525|delta/epsilon subdivisions,2WMNG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Haem-binding uptake, Tiki superfamily, ChaN	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg
CMS2_k127_6259523_43	1219084.AP014508_gene723	1.101e-31	140.0	COG1315@1|root,COG1315@2|Bacteria,2GC4H@200918|Thermotogae	200918|Thermotogae	L	PALM domain HD hydrolase domain and	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA
CMS2_k127_6259523_57	865861.AZSU01000002_gene2572	1.477e-13	76.0	2E6A2@1|root,330XY@2|Bacteria,1VISZ@1239|Firmicutes,24QK3@186801|Clostridia,36UF4@31979|Clostridiaceae	186801|Clostridia	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
CMS2_k127_6259523_21	742725.HMPREF9450_01117	4.013e-92	319.0	COG2271@1|root,COG2271@2|Bacteria,4PKTC@976|Bacteroidetes,2G3HT@200643|Bacteroidia,22V02@171550|Rikenellaceae	976|Bacteroidetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS2_k127_6259523_8	453591.Igni_1382	5.518e-188	605.0	COG1509@1|root,arCOG03246@2157|Archaea,2XS4B@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM lysine 2,3-aminomutase YodO family protein	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	-
CMS2_k127_6259523_37	880073.Calab_1320	1.211e-42	179.0	COG0739@1|root,COG0739@2|Bacteria,2NR6F@2323|unclassified Bacteria	2|Bacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CMS2_k127_6259523_53	395961.Cyan7425_5125	7.407e-18	91.0	COG5464@1|root,COG5464@2|Bacteria,1G2UF@1117|Cyanobacteria,3KHMX@43988|Cyanothece	1117|Cyanobacteria	S	transposase or invertase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351
CMS2_k127_6259523_3	1195236.CTER_2680	1.722e-253	796.0	COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia,3WHGT@541000|Ruminococcaceae	186801|Clostridia	E	asparagine synthase (glutamine-hydrolyzing)	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7,NAD_synthase
CMS2_k127_6259523_39	357244.OTBS_1565	3.544e-36	146.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2TRWR@28211|Alphaproteobacteria,47F63@766|Rickettsiales	766|Rickettsiales	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
CMS2_k127_6259523_40	1123248.KB893326_gene1287	3.429e-35	146.0	COG0671@1|root,COG0671@2|Bacteria,4NF34@976|Bacteroidetes	976|Bacteroidetes	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
CMS2_k127_6259523_51	1047013.AQSP01000110_gene56	6.276e-20	106.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS2_k127_6259523_15	118166.JH976538_gene5057	1.203e-116	400.0	COG4191@1|root,COG4191@2|Bacteria,1G1PE@1117|Cyanobacteria,1H8US@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,Response_reg
CMS2_k127_6259523_33	765420.OSCT_2222	1.419e-52	190.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	MA20_29145	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_6259523_52	1237149.C900_00063	2.583e-19	100.0	29YSB@1|root,30KNC@2|Bacteria,4P93C@976|Bacteroidetes	976|Bacteroidetes	S	Domain of unknown function (DUF4154)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154
CMS2_k127_6259523_55	443143.GM18_0108	9.84e-16	91.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,EAL,GGDEF,PAS_4
CMS2_k127_6259523_27	765420.OSCT_2223	8.751e-68	250.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
CMS2_k127_6259523_23	1047013.AQSP01000123_gene1544	5.038e-90	315.0	COG0612@1|root,COG0612@2|Bacteria,2NR0Z@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	ymxG	-	-	ko:K07263,ko:K07623	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_6259523_17	1047013.AQSP01000123_gene1543	2.552e-104	355.0	COG0612@1|root,COG0612@2|Bacteria,2NQ4N@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_6259523_59	411476.BACOVA_05614	1.292e-11	71.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,2FWSR@200643|Bacteroidia,4AV24@815|Bacteroidaceae	976|Bacteroidetes	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_6259523_6	1237149.C900_04816	1.821e-209	702.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47TR0@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Response_reg,Y_Y_Y
CMS2_k127_6259523_25	880073.Calab_1352	2.796e-87	293.0	COG0529@1|root,COG0529@2|Bacteria,2NPBJ@2323|unclassified Bacteria	2|Bacteria	P	Catalyzes the synthesis of activated sulfate	cysC	GO:0000096,GO:0000103,GO:0003674,GO:0003824,GO:0004779,GO:0004781,GO:0006082,GO:0006520,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010134,GO:0016740,GO:0016772,GO:0016779,GO:0019379,GO:0019419,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0070566,GO:0071704,GO:1901564	2.7.1.25,2.7.7.4	ko:K00860,ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
CMS2_k127_6259523_26	273068.TTE2709	1.343e-70	250.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,42F9Z@68295|Thermoanaerobacterales	186801|Clostridia	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS2_k127_6259523_61	1289135.A966_02213	4.215e-10	68.0	COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	mcp2	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
CMS2_k127_6259523_49	1174528.JH992898_gene1810	2.798e-22	109.0	COG0420@1|root,COG0420@2|Bacteria,1FZXM@1117|Cyanobacteria,1JH17@1189|Stigonemataceae	1117|Cyanobacteria	L	Calcineurin-like phosphoesterase	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
CMS2_k127_6259523_28	264462.Bd0254	1.304e-65	246.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342,ko:K03703,ko:K04096	ko00230,ko00240,ko01100,ko03030,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03420,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DUF4357,GIY-YIG,RNase_T
CMS2_k127_6259523_4	1321778.HMPREF1982_02247	1.019e-248	790.0	COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia,267T0@186813|unclassified Clostridiales	186801|Clostridia	KL	HELICc2	dinG	-	3.1.12.1,3.6.4.12	ko:K07464,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400	-	-	-	DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1
CMS2_k127_6259523_22	1379698.RBG1_1C00001G1816	2.582e-91	327.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,2NR9R@2323|unclassified Bacteria	2|Bacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT_2,TPR_8
CMS2_k127_6259523_36	32057.KB217483_gene9781	1.067e-42	162.0	COG1335@1|root,COG1335@2|Bacteria,1GAHK@1117|Cyanobacteria	1117|Cyanobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS2_k127_6259523_31	1507.HMPREF0262_01999	1.568e-58	226.0	COG4692@1|root,COG4692@2|Bacteria,1UJSZ@1239|Firmicutes,25AZC@186801|Clostridia	186801|Clostridia	G	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
CMS2_k127_6259523_9	1121904.ARBP01000001_gene5480	5.303e-158	508.0	COG3191@1|root,COG3191@2|Bacteria,4NGDT@976|Bacteroidetes,47K9S@768503|Cytophagia	976|Bacteroidetes	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
CMS2_k127_6259523_50	1220551.SCHR_10995	1.896e-21	106.0	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,4HA4B@91061|Bacilli,4GXZY@90964|Staphylococcaceae	91061|Bacilli	K	response regulator	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
CMS2_k127_6259523_54	96561.Dole_1357	7.952e-17	92.0	COG0745@1|root,COG0745@2|Bacteria,1QW16@1224|Proteobacteria,43BR7@68525|delta/epsilon subdivisions,2X723@28221|Deltaproteobacteria,2MPIZ@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_6259523_42	1121324.CLIT_2c02780	1.54e-32	145.0	COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,25F1F@186801|Clostridia	186801|Clostridia	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS2_k127_6259523_62	927677.ALVU02000001_gene926	5.124e-10	72.0	COG3322@1|root,COG5001@1|root,COG3322@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria	1117|Cyanobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,EAL,GGDEF,PAS_3,PAS_4,PAS_9
CMS2_k127_6259523_64	349161.Dred_1774	1.513e-05	55.0	2FAMH@1|root,342VB@2|Bacteria,1VWX1@1239|Firmicutes,251HA@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6259523_10	933262.AXAM01000030_gene806	4.288e-155	498.0	COG1032@1|root,COG1032@2|Bacteria,1PTN9@1224|Proteobacteria,42MG9@68525|delta/epsilon subdivisions,2WJYU@28221|Deltaproteobacteria,2MIRY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_6259523_0	479434.Sthe_2668	0.0	1245.0	COG4447@1|root,COG4447@2|Bacteria,2G678@200795|Chloroflexi,27YSS@189775|Thermomicrobia	189775|Thermomicrobia	S	PFAM glycosyl hydrolase BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
CMS2_k127_6259523_18	1168034.FH5T_00075	3.718e-102	347.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	OMP_b-brl,Toluene_X
CMS2_k127_6259523_14	552811.Dehly_0560	2.145e-117	392.0	COG2379@1|root,COG2379@2|Bacteria,2G5RZ@200795|Chloroflexi	200795|Chloroflexi	G	PFAM MOFRL domain protein	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
CMS2_k127_6259523_58	111781.Lepto7376_0368	3.217e-13	77.0	COG1345@1|root,COG1345@2|Bacteria	2|Bacteria	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	GO:0001539,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
CMS2_k127_6259762_0	1047013.AQSP01000106_gene1757	1.072e-203	646.0	COG4690@1|root,COG4690@2|Bacteria,2NQBZ@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family C69	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
CMS2_k127_6259762_6	1123400.KB904767_gene3414	1.002e-05	60.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1SZ81@1236|Gammaproteobacteria,463MG@72273|Thiotrichales	72273|Thiotrichales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS2_k127_6259762_4	573061.Clocel_0914	1.402e-22	115.0	COG1572@1|root,COG1572@2|Bacteria,1UVYI@1239|Firmicutes,250YY@186801|Clostridia,36Q2E@31979|Clostridiaceae	186801|Clostridia	N	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
CMS2_k127_6259762_5	1144275.COCOR_05037	1.229e-07	66.0	COG0747@1|root,COG3291@1|root,COG0747@2|Bacteria,COG3291@2|Bacteria,1QX9G@1224|Proteobacteria,43C2P@68525|delta/epsilon subdivisions,2X7D9@28221|Deltaproteobacteria,2Z3FQ@29|Myxococcales	28221|Deltaproteobacteria	E	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PA,Peptidase_M36,REJ
CMS2_k127_6259762_2	1121904.ARBP01000013_gene290	1.48e-133	473.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47Y22@768503|Cytophagia	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HAMP,HATPase_c,HTH_18,HisKA,PAS_3,PAS_4,PAS_9,Reg_prop,Response_reg,Y_Y_Y
CMS2_k127_6259762_3	391587.KAOT1_21507	1.36e-123	413.0	COG3119@1|root,COG3119@2|Bacteria,4P1GI@976|Bacteroidetes,1I7V6@117743|Flavobacteriia	976|Bacteroidetes	P	Domain of unknown function (DUF4976)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_6259762_1	1532558.JL39_15410	8.424e-174	553.0	COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,2U0BU@28211|Alphaproteobacteria,4BHBC@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS2_k127_6262795_6	394503.Ccel_2381	1.577e-133	451.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_31,PP-binding,ketoacyl-synt
CMS2_k127_6262795_5	243265.plu0382	7.003e-135	439.0	COG2865@1|root,COG2865@2|Bacteria,1R4MD@1224|Proteobacteria,1RQTX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_24
CMS2_k127_6262795_1	880072.Desac_0721	3.17e-320	1003.0	COG0613@1|root,COG1196@1|root,COG0613@2|Bacteria,COG1196@2|Bacteria,1PRIC@1224|Proteobacteria,42MSM@68525|delta/epsilon subdivisions,2WPPR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23
CMS2_k127_6262795_0	1117108.PAALTS15_15431	0.0	2455.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6262795_2	1121121.KB894288_gene2764	5.56e-241	784.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6262795_18	1123299.AUKZ01000011_gene1077	1.433e-24	115.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,PS_pyruv_trans,Radical_SAM,SPASM
CMS2_k127_6262795_4	1085623.GNIT_2117	3.538e-147	487.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,46415@72275|Alteromonadaceae	1236|Gammaproteobacteria	OU	COG0616 Periplasmic serine proteases (ClpP class)	sppA	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
CMS2_k127_6262795_7	1121930.AQXG01000010_gene3086	8.696e-130	424.0	COG0389@1|root,COG0389@2|Bacteria,4NF1Y@976|Bacteroidetes,1IP49@117747|Sphingobacteriia	976|Bacteroidetes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
CMS2_k127_6262795_12	485913.Krac_3036	4.035e-73	251.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	nudK	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0046872,GO:0052751	3.6.1.13	ko:K01515,ko:K12945	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	iLF82_1304.LF82_1537,iNRG857_1313.NRG857_12310,iUTI89_1310.UTI89_C2793,ic_1306.c2994	NUDIX
CMS2_k127_6262795_24	1313421.JHBV01000008_gene4503	1.469e-08	62.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	ansR5	-	-	ko:K22300	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3,HTH_31
CMS2_k127_6262795_11	7668.SPU_012288-tr	9.96e-89	299.0	COG1028@1|root,KOG0725@2759|Eukaryota,38BUC@33154|Opisthokonta,3BC34@33208|Metazoa,3D09G@33213|Bilateria	33208|Metazoa	Q	Oxidoreductase activity. It is involved in the biological process described with metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS2_k127_6262795_3	1047013.AQSP01000115_gene336	2.795e-188	623.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NNRF@2323|unclassified Bacteria	2|Bacteria	MU	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,2.C.1.2	-	-	BSP,Bac_surface_Ag,PD40,Peptidase_MA_2,TolB_N
CMS2_k127_6262795_15	1122605.KB893626_gene2805	6.006e-30	123.0	COG0736@1|root,COG0736@2|Bacteria,4P5DA@976|Bacteroidetes	976|Bacteroidetes	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
CMS2_k127_6262795_17	1121930.AQXG01000011_gene1726	4.346e-27	115.0	COG1366@1|root,COG1366@2|Bacteria,4NZCC@976|Bacteroidetes	976|Bacteroidetes	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS2_k127_6262795_21	880073.Calab_0681	1.834e-13	76.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2NP51@2323|unclassified Bacteria	2|Bacteria	KT	Sigma factor PP2C-like phosphatases	pkn5	-	2.7.11.1,3.1.3.3	ko:K04757,ko:K07315	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	AAA_16,GAF,HAMP,HATPase_c_2,Pkinase,SpoIIE,dCache_1
CMS2_k127_6262795_13	945713.IALB_0830	1.225e-59	222.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbU	-	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	GAF,GAF_2,GAF_3,HATPase_c_2,SSF,SpoIIE
CMS2_k127_6262795_22	742722.HMPREF9463_00025	6.145e-12	67.0	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria,4CWG7@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
CMS2_k127_6262795_26	1121448.DGI_2989	1.497e-06	53.0	COG0594@1|root,COG0594@2|Bacteria,1NGQJ@1224|Proteobacteria,42VBC@68525|delta/epsilon subdivisions,2WRF0@28221|Deltaproteobacteria,2MD4U@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
CMS2_k127_6262795_16	642492.Clole_4271	2.471e-29	119.0	COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,24QN4@186801|Clostridia	186801|Clostridia	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
CMS2_k127_6262795_9	1047013.AQSP01000133_gene2153	4.536e-92	325.0	COG0706@1|root,COG0706@2|Bacteria,2NP6C@2323|unclassified Bacteria	2|Bacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
CMS2_k127_6262795_19	1336241.JAEB01000015_gene1631	1.167e-19	97.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,25UVE@186806|Eubacteriaceae	186801|Clostridia	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
CMS2_k127_6262795_10	161156.JQKW01000006_gene1096	1.066e-89	312.0	COG0486@1|root,COG0486@2|Bacteria,2GHES@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
CMS2_k127_6262795_8	1499967.BAYZ01000100_gene3468	2.508e-128	414.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS2_k127_6262795_25	555779.Dthio_PD1518	8.257e-08	58.0	COG5464@1|root,COG5464@2|Bacteria,1MUSP@1224|Proteobacteria,431AM@68525|delta/epsilon subdivisions,2WWZH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	transposase YhgA family protein	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_31
CMS2_k127_6262795_23	926561.KB900618_gene4	7.571e-12	70.0	COG5464@1|root,COG5464@2|Bacteria,1TPB1@1239|Firmicutes,24B0D@186801|Clostridia	186801|Clostridia	S	COG NOG17660 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,PDDEXK_2
CMS2_k127_6262795_14	1499967.BAYZ01000021_gene207	3.722e-57	211.0	2DSRS@1|root,33H75@2|Bacteria	2|Bacteria	S	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
CMS2_k127_6270747_1	1196323.ALKF01000205_gene4116	5.146e-252	794.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6270747_0	573061.Clocel_2482	0.0	1369.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_6270747_2	711393.AYRX01000103_gene5911	1.785e-41	160.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Radical_SAM
CMS2_k127_6284796_4	358681.BBR47_27890	5.141e-126	419.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_6284796_3	1174528.JH992890_gene591	3.366e-209	668.0	COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria	2|Bacteria	O	carbamoyl transferase, NodU family	nolO	-	-	ko:K00612,ko:K16035	ko01051,ko01052,ko01130,map01051,map01052,map01130	-	R09853,R09858	RC00055,RC02840	ko00000,ko00001,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS2_k127_6284796_0	1196323.ALKF01000205_gene4114	0.0	1590.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6284796_2	509191.AEDB02000085_gene2708	2.972e-230	762.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6284796_1	755731.Clo1100_2633	0.0	1215.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6284796_5	1123229.AUBC01000012_gene2735	4.044e-06	51.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,3JQP1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Domain of unknown function (DUF4070)	MA20_17485	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_6287004_19	4792.ETI50120	0.0008582	48.0	COG4886@1|root,KOG0531@2759|Eukaryota	2759|Eukaryota	L	axoneme assembly	-	-	-	-	-	-	-	-	-	-	-	-	LRR_4,LRR_8,LRR_9
CMS2_k127_6287004_7	273068.TTE2746	3.346e-52	201.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,24A6D@186801|Clostridia,42J4J@68295|Thermoanaerobacterales	186801|Clostridia	C	Best Blastp hit gi 7462068 pir H72266 astB chuR-related protein - Thermotoga maritima (strain MSB8) gi 4981883 gb AAD36396.1 AE001787_1 (AE001787) astB chuR-related protein Thermotoga maritima , score	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
CMS2_k127_6287004_1	1047013.AQSP01000140_gene2462	1.671e-131	428.0	COG0438@1|root,COG0438@2|Bacteria,2NQE7@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
CMS2_k127_6287004_15	891968.Anamo_0102	4.346e-13	80.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS2_k127_6287004_3	555079.Toce_0387	4.236e-64	230.0	COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,42FCC@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
CMS2_k127_6287004_6	709991.Odosp_1431	1.843e-53	194.0	COG0237@1|root,COG0237@2|Bacteria	2|Bacteria	H	dephospho-CoA kinase activity	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24,3.2.2.23,4.2.99.18	ko:K00859,ko:K08309,ko:K10563	ko00770,ko01100,ko03410,map00770,map01100,map03410	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01011,ko03400	-	GH23	iIT341.HP0831	CoaE
CMS2_k127_6287004_5	1286171.EAL2_c14570	1.493e-53	192.0	COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia,25WCF@186806|Eubacteriaceae	186801|Clostridia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
CMS2_k127_6287004_4	1047013.AQSP01000099_gene1493	9.965e-64	222.0	COG2131@1|root,COG2131@2|Bacteria,2NPW9@2323|unclassified Bacteria	2|Bacteria	F	MafB19-like deaminase	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
CMS2_k127_6287004_8	1121091.AUMP01000001_gene154	1.595e-50	207.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli	91061|Bacilli	KLT	serine threonine protein kinase	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_6287004_0	1519464.HY22_05910	1.127e-158	539.0	COG0642@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria,1FEYZ@1090|Chlorobi	1090|Chlorobi	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,Y_Y_Y
CMS2_k127_6287004_2	398512.JQKC01000041_gene4130	4.531e-80	274.0	COG1409@1|root,COG1409@2|Bacteria,1V9RB@1239|Firmicutes,250UH@186801|Clostridia	186801|Clostridia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_6287004_13	706587.Desti_0629	1.134e-21	95.0	COG5450@1|root,COG5450@2|Bacteria,1Q2TR@1224|Proteobacteria,42W8I@68525|delta/epsilon subdivisions,2WRTI@28221|Deltaproteobacteria,2MS5V@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
CMS2_k127_6287004_10	316067.Geob_3270	1.807e-38	147.0	COG1487@1|root,COG1487@2|Bacteria,1MZZ9@1224|Proteobacteria,42UZN@68525|delta/epsilon subdivisions,2WQ62@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_6287004_14	744872.Spica_0350	1.933e-19	90.0	COG2336@1|root,COG2336@2|Bacteria,2JB20@203691|Spirochaetes	203691|Spirochaetes	T	PFAM SpoVT AbrB	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6287004_11	290397.Adeh_2871	4.065e-37	143.0	COG3654@1|root,COG3654@2|Bacteria,1N1FW@1224|Proteobacteria,42V74@68525|delta/epsilon subdivisions,2WR7E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Fic/DOC family	-	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
CMS2_k127_6287004_9	551789.ATVJ01000001_gene2293	2.011e-40	156.0	COG5403@1|root,COG5403@2|Bacteria,1N0H4@1224|Proteobacteria,2UFMN@28211|Alphaproteobacteria,43XNE@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
CMS2_k127_6287004_17	1047013.AQSP01000115_gene360	3.493e-10	72.0	COG2165@1|root,COG2165@2|Bacteria,2NQ2Y@2323|unclassified Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS2_k127_6287004_16	443143.GM18_3862	1.361e-12	67.0	COG1917@1|root,COG1917@2|Bacteria,1MZD8@1224|Proteobacteria,42W0P@68525|delta/epsilon subdivisions,2WRDR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS2_k127_6296120_0	768670.Calni_0857	1.01e-05	59.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,DEAD,DUF4384,Helicase_C,Peptidase_C14,Polysacc_deac_1,TPR_11,TPR_16,TPR_2,TPR_8,WD40
CMS2_k127_6320999_1	1296416.JACB01000073_gene3739	2.84e-126	424.0	COG2227@1|root,COG3321@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,4PKD5@976|Bacteroidetes,1HYG4@117743|Flavobacteriia,2YIVB@290174|Aquimarina	976|Bacteroidetes	Q	PKS_PP_betabranch	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_6320999_0	1317122.ATO12_04955	3.014e-256	815.0	COG2227@1|root,COG3321@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,4PKD5@976|Bacteroidetes,1HYG4@117743|Flavobacteriia,2YIVB@290174|Aquimarina	976|Bacteroidetes	Q	PKS_PP_betabranch	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_63462_3	410358.Mlab_1682	5.183e-45	176.0	COG0515@1|root,arCOG03682@2157|Archaea	2157|Archaea	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS2_k127_63462_6	1122947.FR7_2698	8.36e-19	98.0	2EWFR@1|root,33PU5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_63462_5	1232437.KL661986_gene3671	1.182e-19	91.0	2E5AT@1|root,3302X@2|Bacteria,1N70A@1224|Proteobacteria,42XRH@68525|delta/epsilon subdivisions,2WSU1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
CMS2_k127_63462_4	573413.Spirs_3402	5.545e-33	130.0	COG3041@1|root,COG3041@2|Bacteria,2JAWT@203691|Spirochaetes	203691|Spirochaetes	S	Addiction module toxin RelE StbE family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_63462_1	391603.FBALC1_13072	0.0	1150.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1HYJJ@117743|Flavobacteriia	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	PD40,PDZ_2,Peptidase_S41,Tricorn_C1
CMS2_k127_63462_2	1499689.CCNN01000009_gene2721	3.327e-76	268.0	COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,36EEA@31979|Clostridiaceae	186801|Clostridia	E	Cleaves the N-terminal amino acid of tripeptides	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS2_k127_63462_0	697284.ERIC2_c18040	0.0	1685.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6382780_9	929556.Solca_2127	1.532e-07	61.0	COG2020@1|root,COG2020@2|Bacteria,4PGXX@976|Bacteroidetes,1IUNY@117747|Sphingobacteriia	976|Bacteroidetes	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CMS2_k127_6382780_7	324925.Ppha_0871	4.27e-71	253.0	COG0332@1|root,COG0332@2|Bacteria,1FD8U@1090|Chlorobi	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS2_k127_6382780_2	1196323.ALKF01000138_gene3468	0.0	1891.0	COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_6382780_3	215803.DB30_3640	0.0	1637.0	COG3321@1|root,COG3321@2|Bacteria,1Q52Y@1224|Proteobacteria,43A3Z@68525|delta/epsilon subdivisions,2XA2T@28221|Deltaproteobacteria,2YTU6@29|Myxococcales	28221|Deltaproteobacteria	Q	PKS_KR	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
CMS2_k127_6382780_4	1449050.JNLE01000003_gene2072	4.691e-230	746.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13612	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_6382780_0	448385.sce4136	0.0	2020.0	COG3321@1|root,COG3321@2|Bacteria,1Q52Y@1224|Proteobacteria,43A3Z@68525|delta/epsilon subdivisions,2XA2T@28221|Deltaproteobacteria,2YTU6@29|Myxococcales	28221|Deltaproteobacteria	Q	PKS_KR	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_6382780_1	485918.Cpin_5296	0.0	1904.0	COG0236@1|root,COG0500@1|root,COG0604@1|root,COG1028@1|root,COG2227@1|root,COG3321@1|root,COG0236@2|Bacteria,COG0604@2|Bacteria,COG1028@2|Bacteria,COG2226@2|Bacteria,COG2227@2|Bacteria,COG3321@2|Bacteria,4PKD5@976|Bacteroidetes,1IPC0@117747|Sphingobacteriia	976|Bacteroidetes	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_6382780_6	324925.Ppha_0871	1.47e-72	256.0	COG0332@1|root,COG0332@2|Bacteria,1FD8U@1090|Chlorobi	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS2_k127_6382780_5	290402.Cbei_0690	1.939e-126	413.0	COG1533@1|root,COG1533@2|Bacteria,1UU63@1239|Firmicutes	1239|Firmicutes	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF1848,Radical_SAM
CMS2_k127_6382780_10	290402.Cbei_0689	2.827e-07	57.0	2EDGR@1|root,337CY@2|Bacteria,1VH47@1239|Firmicutes,24THK@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
CMS2_k127_6382780_8	109760.SPPG_04984T0	5.932e-11	74.0	KOG3689@1|root,KOG3689@2759|Eukaryota,38BQB@33154|Opisthokonta	33154|Opisthokonta	T	3',5'-cyclic-GMP phosphodiesterase activity	PDE2A	GO:0000122,GO:0000166,GO:0000302,GO:0001101,GO:0001568,GO:0001885,GO:0001944,GO:0002064,GO:0002082,GO:0002237,GO:0002376,GO:0002520,GO:0002521,GO:0002573,GO:0003008,GO:0003013,GO:0003018,GO:0003158,GO:0003170,GO:0003205,GO:0003231,GO:0003279,GO:0003281,GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0004118,GO:0005102,GO:0005215,GO:0005216,GO:0005261,GO:0005262,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005743,GO:0005759,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0006139,GO:0006140,GO:0006152,GO:0006163,GO:0006195,GO:0006198,GO:0006355,GO:0006357,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0006935,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0007186,GO:0007187,GO:0007188,GO:0007193,GO:0007275,GO:0007507,GO:0007568,GO:0007602,GO:0007610,GO:0007635,GO:0008015,GO:0008081,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0008340,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009126,GO:0009128,GO:0009150,GO:0009154,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009167,GO:0009169,GO:0009187,GO:0009214,GO:0009259,GO:0009261,GO:0009268,GO:0009314,GO:0009410,GO:0009416,GO:0009581,GO:0009582,GO:0009583,GO:0009605,GO:0009606,GO:0009607,GO:0009612,GO:0009617,GO:0009628,GO:0009636,GO:0009719,GO:0009888,GO:0009889,GO:0009890,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010259,GO:0010446,GO:0010468,GO:0010469,GO:0010556,GO:0010558,GO:0010563,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010646,GO:0010647,GO:0010648,GO:0010752,GO:0010753,GO:0010754,GO:0010821,GO:0010941,GO:0012505,GO:0014070,GO:0014074,GO:0015075,GO:0015085,GO:0015267,GO:0015318,GO:0016020,GO:0016787,GO:0016788,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019866,GO:0019867,GO:0019904,GO:0019932,GO:0019933,GO:0019934,GO:0019935,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0022898,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030001,GO:0030097,GO:0030099,GO:0030154,GO:0030224,GO:0030424,GO:0030425,GO:0030545,GO:0030551,GO:0030552,GO:0030553,GO:0030554,GO:0030855,GO:0030911,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031347,GO:0031349,GO:0031966,GO:0031967,GO:0031968,GO:0031974,GO:0031975,GO:0032101,GO:0032103,GO:0032386,GO:0032387,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032496,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032879,GO:0032880,GO:0033043,GO:0033157,GO:0033158,GO:0033159,GO:0033993,GO:0034097,GO:0034220,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0035556,GO:0035690,GO:0035904,GO:0036004,GO:0036005,GO:0036006,GO:0036094,GO:0036477,GO:0040008,GO:0040011,GO:0040012,GO:0040014,GO:0040017,GO:0040018,GO:0042056,GO:0042221,GO:0042278,GO:0042306,GO:0042308,GO:0042325,GO:0042326,GO:0042330,GO:0042454,GO:0042493,GO:0042542,GO:0042578,GO:0042734,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043114,GO:0043116,GO:0043117,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043269,GO:0043271,GO:0043467,GO:0043577,GO:0043949,GO:0043951,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044302,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0045121,GO:0045202,GO:0045446,GO:0045892,GO:0045927,GO:0045934,GO:0045936,GO:0045980,GO:0046037,GO:0046038,GO:0046058,GO:0046068,GO:0046069,GO:0046128,GO:0046130,GO:0046434,GO:0046483,GO:0046662,GO:0046677,GO:0046683,GO:0046700,GO:0046822,GO:0046823,GO:0046873,GO:0046983,GO:0047555,GO:0048018,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048520,GO:0048522,GO:0048523,GO:0048534,GO:0048583,GO:0048584,GO:0048585,GO:0048638,GO:0048639,GO:0048731,GO:0048856,GO:0048869,GO:0050727,GO:0050729,GO:0050789,GO:0050793,GO:0050794,GO:0050795,GO:0050896,GO:0050918,GO:0050920,GO:0050921,GO:0051049,GO:0051051,GO:0051094,GO:0051128,GO:0051171,GO:0051172,GO:0051174,GO:0051179,GO:0051223,GO:0051224,GO:0051234,GO:0051239,GO:0051240,GO:0051252,GO:0051253,GO:0051591,GO:0051606,GO:0051704,GO:0051707,GO:0051716,GO:0055085,GO:0055086,GO:0060255,GO:0060341,GO:0060429,GO:0060548,GO:0060840,GO:0060976,GO:0061028,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070201,GO:0070305,GO:0070482,GO:0070588,GO:0070838,GO:0070848,GO:0070887,GO:0071214,GO:0071216,GO:0071219,GO:0071222,GO:0071260,GO:0071310,GO:0071320,GO:0071321,GO:0071345,GO:0071363,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071496,GO:0071559,GO:0071560,GO:0071704,GO:0071944,GO:0072358,GO:0072359,GO:0072511,GO:0072521,GO:0072523,GO:0080090,GO:0080134,GO:0090087,GO:0090317,GO:0090324,GO:0097011,GO:0097012,GO:0097060,GO:0097159,GO:0097367,GO:0097447,GO:0097457,GO:0097458,GO:0098588,GO:0098589,GO:0098590,GO:0098655,GO:0098660,GO:0098662,GO:0098772,GO:0098793,GO:0098805,GO:0098857,GO:0104004,GO:0120025,GO:0120038,GO:1900180,GO:1900181,GO:1900542,GO:1900543,GO:1901046,GO:1901068,GO:1901069,GO:1901135,GO:1901136,GO:1901265,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901419,GO:1901421,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902159,GO:1902160,GO:1902531,GO:1902532,GO:1902533,GO:1902679,GO:1903131,GO:1903506,GO:1903507,GO:1903578,GO:1903579,GO:1903827,GO:1903828,GO:1904589,GO:1904590,GO:1904612,GO:1904613,GO:1904880,GO:1904950,GO:1905957,GO:1905959,GO:1990834,GO:2000112,GO:2000113,GO:2000241,GO:2000243,GO:2001141	3.1.4.17	ko:K18283	ko00230,ko04022,ko04740,ko04925,ko05032,map00230,map04022,map04740,map04925,map05032	M00694	R00191,R01234	RC00296	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,GAF_2,PDEase_I
CMS2_k127_6384541_13	324925.Ppha_2349	2.455e-20	105.0	COG1262@1|root,COG1409@1|root,COG5635@1|root,COG1262@2|Bacteria,COG1409@2|Bacteria,COG5635@2|Bacteria,1FEK9@1090|Chlorobi	2|Bacteria	T	NACHT nucleoside triphosphatase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,Metallophos,PEGA
CMS2_k127_6384541_12	289376.THEYE_A1079	3.409e-22	98.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	ko:K07339	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HicA_toxin
CMS2_k127_6384541_10	565033.GACE_0087	1.781e-28	116.0	COG1598@1|root,arCOG02411@2157|Archaea,2Y6IM@28890|Euryarchaeota,247DB@183980|Archaeoglobi	183980|Archaeoglobi	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
CMS2_k127_6384541_0	1191523.MROS_2798	0.0	1215.0	COG0574@1|root,COG0574@2|Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_2,PPDK_N,Response_reg
CMS2_k127_6384541_1	1191523.MROS_2800	1.154e-234	731.0	COG0334@1|root,COG0334@2|Bacteria	2|Bacteria	E	glutamate dehydrogenase [NAD(P)+] activity	gluD	GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.2,1.4.1.3,1.4.1.4	ko:K00260,ko:K00261,ko:K00262	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.gdhA	ELFV_dehydrog,ELFV_dehydrog_N
CMS2_k127_6384541_15	1449063.JMLS01000029_gene525	7.768e-16	86.0	COG2186@1|root,COG2186@2|Bacteria,1V33N@1239|Firmicutes,4HGDB@91061|Bacilli,26QYC@186822|Paenibacillaceae	91061|Bacilli	K	FCD	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS2_k127_6384541_2	1047013.AQSP01000096_gene2182	9.036e-130	437.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	prrA	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
CMS2_k127_6384541_6	1047013.AQSP01000130_gene1856	2.531e-94	315.0	COG3836@1|root,COG3836@2|Bacteria,2NPSY@2323|unclassified Bacteria	2|Bacteria	G	HpcH/HpaI aldolase/citrate lyase family	MA20_09190	-	2.7.7.38,4.1.2.20,4.1.2.52	ko:K00979,ko:K01630,ko:K02510	ko00053,ko00350,ko00540,ko01100,ko01120,map00053,map00350,map00540,map01100,map01120	M00063	R01645,R01647,R02754,R03277,R03351,R11396	RC00152,RC00307,RC00435,RC00572,RC00574,RC00910,RC03057	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HpcH_HpaI
CMS2_k127_6384541_7	864702.OsccyDRAFT_0895	1.117e-89	307.0	COG0596@1|root,COG0596@2|Bacteria,1G21Y@1117|Cyanobacteria,1H751@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
CMS2_k127_6384541_3	880073.Calab_3134	2.4e-127	431.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,GAF_2,HATPase_c,HisKA,HisKA_2,PAS_3,PAS_4,PAS_9,Response_reg
CMS2_k127_6384541_14	1313304.CALK_0511	8.157e-19	98.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	trxA_1	-	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS2_k127_6384541_9	1265505.ATUG01000002_gene2107	4.363e-32	139.0	COG0607@1|root,COG0607@2|Bacteria,1PE42@1224|Proteobacteria,42V5T@68525|delta/epsilon subdivisions,2WSQG@28221|Deltaproteobacteria,2MNFY@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Rhodanese Homology Domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Rhodanese
CMS2_k127_6384541_5	1487921.DP68_10470	1.94e-118	389.0	COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,2493V@186801|Clostridia,36EJ8@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide	hutG	-	3.5.3.8	ko:K01479	ko00340,ko01100,map00340,map01100	M00045	R02285	RC00221,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
CMS2_k127_6384541_4	596151.DesfrDRAFT_2278	1.15e-118	392.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QB7@68525|delta/epsilon subdivisions,2WM6Y@28221|Deltaproteobacteria,2M881@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
CMS2_k127_6384541_8	439235.Dalk_4709	3.572e-32	130.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	2.7.13.3	ko:K02487,ko:K03407,ko:K06596	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00507	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg
CMS2_k127_6384541_11	880071.Fleli_2197	3.905e-23	106.0	COG1595@1|root,COG1595@2|Bacteria,4NQTP@976|Bacteroidetes,47QT5@768503|Cytophagia	976|Bacteroidetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_6384541_16	1410633.JHWR01000013_gene783	1.312e-05	54.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,24BJ8@186801|Clostridia,27IRK@186928|unclassified Lachnospiraceae	186801|Clostridia	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	FHA,PASTA,Pkinase
CMS2_k127_6408061_1	926560.KE387023_gene3164	1.262e-05	58.0	COG5263@1|root,COG5263@2|Bacteria	2|Bacteria	S	dextransucrase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CAP,CW_binding_1,GLTT,LRR_5,Mac-1,SLH
CMS2_k127_6408061_0	1283300.ATXB01000001_gene2284	9.055e-09	68.0	COG3209@1|root,COG3292@1|root,COG3209@2|Bacteria,COG3292@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	Cu_amine_oxidN1,Tail_P2_I
CMS2_k127_6408506_10	1235802.C823_02162	9.743e-77	270.0	COG1775@1|root,COG1775@2|Bacteria,1TS7H@1239|Firmicutes,2493U@186801|Clostridia,25XI6@186806|Eubacteriaceae	186801|Clostridia	E	2-hydroxyglutaryl-CoA dehydratase, D-component	fldB	-	1.3.7.8,4.2.1.157,4.2.1.167,4.2.1.54	ko:K04113,ko:K20025,ko:K20626,ko:K20903	ko00362,ko00640,ko00643,ko01100,ko01120,ko01220,map00362,map00640,map00643,map01100,map01120,map01220	M00541	R02451,R02963	RC00002,RC00818,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
CMS2_k127_6408506_14	706587.Desti_1758	7.137e-36	154.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria,2MS34@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_6408506_12	1545915.JROG01000011_gene26	1.013e-48	186.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,2TUFR@28211|Alphaproteobacteria,2KB4V@204457|Sphingomonadales	204457|Sphingomonadales	S	Creatinine amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Creatininase
CMS2_k127_6408506_13	1235802.C823_02163	8.509e-41	160.0	COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,25WB2@186806|Eubacteriaceae	186801|Clostridia	I	BadF/BadG/BcrA/BcrD ATPase family	hgdC	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,HGD-D
CMS2_k127_6408506_7	509191.AEDB02000085_gene2708	0.0	1262.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6408506_3	755731.Clo1100_2633	0.0	1575.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6408506_9	402777.KB235898_gene5716	8.672e-132	479.0	COG0604@1|root,COG1020@1|root,COG0604@2|Bacteria,COG1020@2|Bacteria,1GBN8@1117|Cyanobacteria	1117|Cyanobacteria	Q	PFAM Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,AMP-binding,AMP-binding_C,Condensation,Nitroreductase,PP-binding
CMS2_k127_6408506_1	1536774.H70357_19025	0.0	1753.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_6408506_4	755731.Clo1100_2633	0.0	1534.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6408506_2	1121121.KB894288_gene2765	0.0	1729.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_6408506_6	1196323.ALKF01000205_gene4116	0.0	1358.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6408506_8	1173024.KI912151_gene2458	5.215e-256	828.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria	1117|Cyanobacteria	Q	Amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_6408506_5	1174528.JH992893_gene6024	0.0	1399.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_6408506_0	755731.Clo1100_0890	0.0	2100.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6408506_11	1034769.KB910518_gene3546	5.972e-50	182.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_6412127_3	517418.Ctha_0598	0.0001255	52.0	COG3267@1|root,COG3267@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,NB-ARC,TPR_10,TniB
CMS2_k127_6412127_2	41431.PCC8801_0162	2.942e-52	193.0	COG0515@1|root,COG0515@2|Bacteria	41431.PCC8801_0162|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6412127_4	1297581.H919_04264	0.0002643	43.0	COG5464@1|root,COG5464@2|Bacteria	2|Bacteria	S	double-stranded DNA endodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6412127_0	755731.Clo1100_2633	0.0	1776.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6412127_1	588581.Cpap_3242	0.0	1377.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_6417973_24	1232437.KL662014_gene1313	4.799e-44	176.0	COG2204@1|root,COG3852@1|root,COG4191@1|root,COG2204@2|Bacteria,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MJ29@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_3,sCache_2
CMS2_k127_6417973_28	1124780.ANNU01000043_gene341	1.915e-19	100.0	COG3228@1|root,COG3228@2|Bacteria,4NGM9@976|Bacteroidetes,47PJA@768503|Cytophagia	976|Bacteroidetes	U	Belongs to the MtfA family	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90,SEC-C
CMS2_k127_6417973_8	933262.AXAM01000005_gene2472	2.679e-108	367.0	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42YHK@68525|delta/epsilon subdivisions,2WUDF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_6417973_6	909663.KI867151_gene2967	7.803e-124	420.0	COG4191@1|root,COG4191@2|Bacteria,1PGQG@1224|Proteobacteria,439Y9@68525|delta/epsilon subdivisions,2X1VH@28221|Deltaproteobacteria,2MRRE@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS2_k127_6417973_0	909663.KI867151_gene2966	0.0	1321.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1NT36@1224|Proteobacteria,42ZEC@68525|delta/epsilon subdivisions,2WU3Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
CMS2_k127_6417973_3	909663.KI867151_gene2965	4.959e-284	882.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MR61@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NADH ubiquinone oxidoreductase, NADH-binding	-	-	1.12.1.3,1.6.5.3	ko:K00124,ko:K00335,ko:K18331	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
CMS2_k127_6417973_22	909663.KI867151_gene2964	1.405e-60	213.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,43DNM@68525|delta/epsilon subdivisions,2X6M5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K05586	ko00190,ko01100,map00190,map01100	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx
CMS2_k127_6417973_14	909663.KI867151_gene2963	1.6e-81	284.0	COG2204@1|root,COG2204@2|Bacteria,1Q5EK@1224|Proteobacteria,433QZ@68525|delta/epsilon subdivisions,2WXYI@28221|Deltaproteobacteria	2|Bacteria	T	cheY-homologous receiver domain	-	-	2.1.1.80,3.1.1.61,3.1.3.3	ko:K03413,ko:K07315,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03021	-	-	-	HATPase_c,HDOD,HD_5,Response_reg
CMS2_k127_6417973_12	379066.GAU_3163	4.193e-87	305.0	COG4403@1|root,COG4403@2|Bacteria	2|Bacteria	V	Lanthionine synthetase C family protein	-	-	-	-	-	-	-	-	-	-	-	-	LANC_like
CMS2_k127_6417973_5	1150474.JQJI01000008_gene1355	7.254e-124	407.0	COG0498@1|root,COG0498@2|Bacteria,2GDZQ@200918|Thermotogae	200918|Thermotogae	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_6417973_27	379066.GAU_1935	1.8e-21	106.0	COG0535@1|root,COG0535@2|Bacteria,1ZT6Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_6417973_17	794903.OPIT5_07380	2.243e-76	264.0	COG0670@1|root,COG0670@2|Bacteria,46VEY@74201|Verrucomicrobia,3K9GN@414999|Opitutae	414999|Opitutae	S	Belongs to the BI1 family	-	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
CMS2_k127_6417973_10	1408473.JHXO01000001_gene2246	1.021e-97	335.0	COG1538@1|root,COG1538@2|Bacteria,4NF4X@976|Bacteroidetes,2FM4A@200643|Bacteroidia	976|Bacteroidetes	MU	Psort location OuterMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_6417973_18	1168034.FH5T_08850	9.004e-76	267.0	COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,2FMFG@200643|Bacteroidia	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
CMS2_k127_6417973_2	1123057.P872_08675	0.0	1172.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47ME1@768503|Cytophagia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS2_k127_6417973_21	1499967.BAYZ01000095_gene4113	7.634e-62	222.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	hoxX	-	-	ko:K19640	-	-	-	-	ko00000,ko02022	-	-	-	ECH_1,Formyl_trans_C,Formyl_trans_N
CMS2_k127_6417973_11	246197.MXAN_6828	1.34e-87	308.0	COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria,438C4@68525|delta/epsilon subdivisions,2WYM4@28221|Deltaproteobacteria,2YWIJ@29|Myxococcales	28221|Deltaproteobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS2_k127_6417973_1	643867.Ftrac_0365	0.0	1178.0	COG4409@1|root,COG4447@1|root,COG4409@2|Bacteria,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47U4M@768503|Cytophagia	976|Bacteroidetes	G	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
CMS2_k127_6417973_20	1123057.P872_17825	5.937e-63	230.0	28HHD@1|root,2Z7T3@2|Bacteria,4NGWB@976|Bacteroidetes,47MPQ@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF3810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3810
CMS2_k127_6417973_15	1185876.BN8_04256	6.306e-80	289.0	COG0296@1|root,COG1680@1|root,COG0296@2|Bacteria,COG1680@2|Bacteria,4NG6Z@976|Bacteroidetes,47PR8@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Beta-lactamase
CMS2_k127_6417973_16	452637.Oter_0318	2.062e-78	268.0	COG0745@1|root,COG0745@2|Bacteria,46UQH@74201|Verrucomicrobia,3K9IM@414999|Opitutae	414999|Opitutae	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_6417973_19	452637.Oter_0317	1.278e-68	250.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,46TQD@74201|Verrucomicrobia,3K9P1@414999|Opitutae	414999|Opitutae	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS2_k127_6417973_23	1047013.AQSP01000033_gene1392	7.358e-45	169.0	2B0BZ@1|root,31SP3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6417973_25	1047013.AQSP01000033_gene1393	4.043e-35	136.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
CMS2_k127_6417973_13	439235.Dalk_4861	4.367e-87	304.0	COG1538@1|root,COG1538@2|Bacteria,1PYD8@1224|Proteobacteria,42P1Y@68525|delta/epsilon subdivisions,2WKZG@28221|Deltaproteobacteria,2MMSN@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
CMS2_k127_6417973_7	1499967.BAYZ01000034_gene1067	5.443e-121	401.0	COG0845@1|root,COG0845@2|Bacteria,2NPBH@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	macA_1	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
CMS2_k127_6417973_9	1499967.BAYZ01000034_gene1068	2.234e-100	331.0	COG1136@1|root,COG1136@2|Bacteria,2NP53@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_6417973_4	439235.Dalk_4858	1.168e-146	474.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2MICK@213118|Desulfobacterales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_6417973_26	765911.Thivi_4236	2.219e-29	118.0	2DNVU@1|root,32ZE7@2|Bacteria,1NFZ4@1224|Proteobacteria,1SG9A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
CMS2_k127_6431922_1	1443665.JACA01000013_gene4100	1.046e-65	241.0	COG2898@1|root,COG3321@1|root,COG2898@2|Bacteria,COG3321@2|Bacteria,4PKD5@976|Bacteroidetes,1HYG4@117743|Flavobacteriia,2YHN1@290174|Aquimarina	976|Bacteroidetes	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Beta_elim_lyase,DUF2156,ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_6431922_0	349520.PPE_03010	0.0	3054.0	COG0236@1|root,COG2227@1|root,COG3321@1|root,COG4221@1|root,COG0236@2|Bacteria,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	pksL	-	-	ko:K13613,ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_6488895_19	697281.Mahau_2532	9.353e-06	48.0	COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,42EVU@68295|Thermoanaerobacterales	186801|Clostridia	S	beta-lactamase domain protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Ada_Zn_binding,Lactamase_B
CMS2_k127_6488895_16	1077285.AGDG01000012_gene3501	6.654e-11	66.0	COG1429@1|root,COG1429@2|Bacteria,4P0BG@976|Bacteroidetes,2FMJ7@200643|Bacteroidia,4AN00@815|Bacteroidaceae	976|Bacteroidetes	H	COG NOG08812 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,PDDEXK_9
CMS2_k127_6488895_17	226186.BT_3432	1.848e-07	56.0	COG1429@1|root,COG1429@2|Bacteria,4P0BG@976|Bacteroidetes,2FMJ7@200643|Bacteroidia,4AN00@815|Bacteroidaceae	976|Bacteroidetes	H	COG NOG08812 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,PDDEXK_9
CMS2_k127_6488895_7	706587.Desti_0312	2.74e-89	306.0	COG0620@1|root,COG0620@2|Bacteria,1R6KI@1224|Proteobacteria,42PCN@68525|delta/epsilon subdivisions,2WKT3@28221|Deltaproteobacteria,2MRRP@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6488895_9	868595.Desca_0350	4.234e-76	263.0	COG3640@1|root,COG3640@2|Bacteria,1TPCY@1239|Firmicutes,247JM@186801|Clostridia,260Q5@186807|Peptococcaceae	186801|Clostridia	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
CMS2_k127_6488895_10	555779.Dthio_PD3240	3.618e-62	222.0	COG3640@1|root,COG3640@2|Bacteria,1R819@1224|Proteobacteria,42PQR@68525|delta/epsilon subdivisions,2WKE4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
CMS2_k127_6488895_2	909663.KI867150_gene97	2.112e-204	657.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MQ8Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
CMS2_k127_6488895_0	555779.Dthio_PD3239	1.83e-294	942.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
CMS2_k127_6488895_8	1123288.SOV_1c07660	8.441e-84	314.0	COG2069@1|root,COG2069@2|Bacteria,1TSSY@1239|Firmicutes,4H6FX@909932|Negativicutes	909932|Negativicutes	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD
CMS2_k127_6488895_5	555779.Dthio_PD3225	3.079e-108	365.0	COG1456@1|root,COG1456@2|Bacteria,1R4RE@1224|Proteobacteria,42M89@68525|delta/epsilon subdivisions,2WJVQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	CO dehydrogenase acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
CMS2_k127_6488895_4	1232410.KI421412_gene86	7.605e-112	369.0	28I7Z@1|root,2Z8AU@2|Bacteria,1NXCQ@1224|Proteobacteria,430Z2@68525|delta/epsilon subdivisions,2WW5U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6488895_1	452637.Oter_4364	6.255e-224	707.0	COG5293@1|root,COG5293@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2326
CMS2_k127_6488895_6	880073.Calab_1121	1.757e-89	305.0	COG1218@1|root,COG1218@2|Bacteria,2NQKA@2323|unclassified Bacteria	2|Bacteria	P	Inositol monophosphatase family	cysQ	-	3.1.3.25,3.1.3.7	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	M00131	R00188,R00508,R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Inositol_P
CMS2_k127_6488895_12	1047013.AQSP01000059_gene2094	1.506e-50	184.0	COG0461@1|root,COG0461@2|Bacteria,2NR56@2323|unclassified Bacteria	2|Bacteria	F	Phosphoribosyl transferase domain	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
CMS2_k127_6488895_3	1047013.AQSP01000132_gene1694	7.338e-114	376.0	COG0463@1|root,COG0463@2|Bacteria,2NP2G@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase like family 2	arnC	GO:0000271,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0030258,GO:0030259,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
CMS2_k127_6488895_11	1089551.KE386572_gene2269	4.635e-57	214.0	COG0438@1|root,COG0438@2|Bacteria,1PHA6@1224|Proteobacteria,2V852@28211|Alphaproteobacteria,4BSY5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4
CMS2_k127_6488895_14	439235.Dalk_2288	7.375e-16	89.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,2MPW6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4150,RHS,RHS_repeat,Transglut_core
CMS2_k127_6530720_15	1047013.AQSP01000139_gene2361	1.15e-71	253.0	COG4974@1|root,COG4974@2|Bacteria,2NP4H@2323|unclassified Bacteria	2|Bacteria	L	Phage integrase, N-terminal SAM-like domain	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS2_k127_6530720_3	562981.HMPREF0428_00152	1.001e-129	428.0	COG1206@1|root,COG1206@2|Bacteria,1TP67@1239|Firmicutes,4HB27@91061|Bacilli,3WDVG@539002|Bacillales incertae sedis	91061|Bacilli	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
CMS2_k127_6530720_19	1268635.Loa_00601	1.263e-60	223.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1JDFM@118969|Legionellales	118969|Legionellales	LU	DNA recombination-mediator protein A	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
CMS2_k127_6530720_27	1047013.AQSP01000139_gene2358	1.685e-42	167.0	COG0589@1|root,COG0589@2|Bacteria,2NPUM@2323|unclassified Bacteria	2|Bacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS2_k127_6530720_39	1379858.N508_01517	5.044e-12	69.0	COG0776@1|root,COG0776@2|Bacteria,2GFUA@200930|Deferribacteres	200930|Deferribacteres	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS2_k127_6530720_12	1121957.ATVL01000007_gene2296	2.187e-88	302.0	COG0639@1|root,COG0639@2|Bacteria,4NIDG@976|Bacteroidetes	976|Bacteroidetes	T	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_6530720_37	292.DM42_6072	2.986e-17	85.0	2EQUD@1|root,33IE5@2|Bacteria,1N9A0@1224|Proteobacteria,2WGHQ@28216|Betaproteobacteria,1KA0H@119060|Burkholderiaceae	28216|Betaproteobacteria	S	YXWGXW repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
CMS2_k127_6530720_10	1410653.JHVC01000009_gene2758	2.515e-95	327.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,36DRG@31979|Clostridiaceae	186801|Clostridia	E	amidohydrolase	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
CMS2_k127_6530720_40	742817.HMPREF9449_01255	1.421e-10	70.0	2FFT5@1|root,347QA@2|Bacteria,4P5W2@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398
CMS2_k127_6530720_28	742817.HMPREF9449_01253	1.538e-40	164.0	COG3034@1|root,COG3034@2|Bacteria,4NU5W@976|Bacteroidetes,2FZAQ@200643|Bacteroidia,2310I@171551|Porphyromonadaceae	976|Bacteroidetes	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
CMS2_k127_6530720_26	518766.Rmar_0611	6.431e-43	166.0	COG1376@1|root,COG1376@2|Bacteria,4P35B@976|Bacteroidetes	976|Bacteroidetes	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
CMS2_k127_6530720_38	485914.Hmuk_0622	1.303e-15	86.0	COG3291@1|root,COG3979@1|root,arCOG02546@2157|Archaea,arCOG07581@2157|Archaea,2Y7P8@28890|Euryarchaeota,23S91@183963|Halobacteria	183963|Halobacteria	G	protein contain chitin-binding domain type 3	-	-	-	-	-	-	-	-	-	-	-	-	CBM_5_12,PKD
CMS2_k127_6530720_0	880072.Desac_1503	1.705e-319	999.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MQ8A@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
CMS2_k127_6530720_17	671143.DAMO_1514	6.799e-66	234.0	COG1806@1|root,COG1806@2|Bacteria,2NRN6@2323|unclassified Bacteria	2|Bacteria	S	Kinase/pyrophosphorylase	yqfL	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
CMS2_k127_6530720_33	526222.Desal_2094	3.961e-24	107.0	COG2259@1|root,COG2259@2|Bacteria,1R0SH@1224|Proteobacteria,43D19@68525|delta/epsilon subdivisions,2X894@28221|Deltaproteobacteria,2MBJN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	MauE
CMS2_k127_6530720_36	269799.Gmet_3018	2.37e-17	89.0	COG0607@1|root,COG0607@2|Bacteria,1N256@1224|Proteobacteria,42TIJ@68525|delta/epsilon subdivisions,2WQHB@28221|Deltaproteobacteria,43V99@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CMS2_k127_6530720_42	1047013.AQSP01000102_gene981	1.153e-07	64.0	28WP9@1|root,2ZINZ@2|Bacteria	1047013.AQSP01000102_gene981|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6530720_5	313612.L8106_12235	2.1e-122	415.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G1QI@1117|Cyanobacteria,1H7BP@1150|Oscillatoriales	1117|Cyanobacteria	NU	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
CMS2_k127_6530720_11	1499967.BAYZ01000104_gene3630	3.911e-89	305.0	COG3012@1|root,COG3012@2|Bacteria	2|Bacteria	-	-	CP_0561	-	-	-	-	-	-	-	-	-	-	-	DUF1186
CMS2_k127_6530720_31	483219.LILAB_17000	2.223e-31	133.0	2CCFH@1|root,301N0@2|Bacteria,1R5U0@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6530720_1	471854.Dfer_1607	3.778e-194	656.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47TR0@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Response_reg,Y_Y_Y
CMS2_k127_6530720_25	43989.cce_0581	5.136e-43	160.0	COG1487@1|root,COG1487@2|Bacteria,1G6RD@1117|Cyanobacteria,3KIG6@43988|Cyanothece	1117|Cyanobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
CMS2_k127_6530720_34	43989.cce_0580	3.961e-24	103.0	COG4456@1|root,COG4456@2|Bacteria,1G95Y@1117|Cyanobacteria	1117|Cyanobacteria	S	Virulence associated protein B	vapB	-	-	ko:K18829	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
CMS2_k127_6530720_44	1321775.HMPREF1980_01544	0.0008481	45.0	COG4118@1|root,COG4118@2|Bacteria,2HRUH@201174|Actinobacteria,4D6U7@85005|Actinomycetales	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
CMS2_k127_6530720_24	331678.Cphamn1_2220	4.582e-43	162.0	COG3744@1|root,COG3744@2|Bacteria	2|Bacteria	S	ribonuclease activity	-	GO:0005575,GO:0005576,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_6530720_8	439235.Dalk_0237	7.24e-103	375.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_6530720_9	1385517.N800_08670	8.476e-97	356.0	COG1361@1|root,COG1361@2|Bacteria,1MUQC@1224|Proteobacteria,1RYHS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	PFAM Peptidase M11 gametolysin	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc,Peptidase_M11
CMS2_k127_6530720_7	909663.KI867151_gene3132	1.53e-109	368.0	COG0774@1|root,COG2204@1|root,COG0774@2|Bacteria,COG2204@2|Bacteria,1MV6T@1224|Proteobacteria,42MVM@68525|delta/epsilon subdivisions,2WJ4I@28221|Deltaproteobacteria,2MRFZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	MT	UDP-3-O-acyl N-acetylglycosamine deacetylase	lpxC	-	3.5.1.108	ko:K02535,ko:K13599	ko00540,ko01100,ko02020,map00540,map01100,map02020	M00060,M00498	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005,ko02022	-	-	-	LpxC
CMS2_k127_6530720_6	309799.DICTH_0749	5.804e-113	400.0	COG0542@1|root,COG0542@2|Bacteria	2|Bacteria	O	response to heat	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
CMS2_k127_6530720_20	1341151.ASZU01000008_gene1395	4.627e-60	234.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,27B9F@186824|Thermoactinomycetaceae	91061|Bacilli	KLT	Serine/Threonine protein kinases, catalytic domain	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_6530720_4	1121468.AUBR01000028_gene1527	4.465e-127	417.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42I2K@68295|Thermoanaerobacterales	186801|Clostridia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS2_k127_6530720_41	667014.Thein_0757	3.387e-10	64.0	COG3350@1|root,COG3350@2|Bacteria	2|Bacteria	T	monooxygenase activity	tmoA	GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0008150,GO:0008152,GO:0009987,GO:0015049,GO:0015050,GO:0015947,GO:0016491,GO:0016705,GO:0016709,GO:0032991,GO:0043446,GO:0044237,GO:0055114,GO:0071704,GO:1902494	1.14.13.227,1.14.13.236,1.14.13.25,1.14.13.69,2.4.1.1	ko:K00688,ko:K15760,ko:K16157,ko:K16242,ko:K18223,ko:K22353,ko:K22357	ko00361,ko00362,ko00500,ko00623,ko00625,ko00640,ko00680,ko01100,ko01110,ko01120,ko01200,ko01220,ko02026,ko04217,ko04910,ko04922,ko04931,map00361,map00362,map00500,map00623,map00625,map00640,map00680,map01100,map01110,map01120,map01200,map01220,map02026,map04217,map04910,map04922,map04931	M00174,M00538,M00548	R01142,R02111,R02550,R03560,R03562,R03608,R05444,R05666,R10042,R10043,R10702,R11901	RC00046,RC00173,RC00269,RC00490,RC01383,RC03249	ko00000,ko00001,ko00002,ko01000	-	GT35	-	Phenol_Hydrox,YHS
CMS2_k127_6530720_43	756067.MicvaDRAFT_5451	4.302e-05	59.0	COG1361@1|root,COG2931@1|root,COG3210@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1G463@1117|Cyanobacteria,1H97Y@1150|Oscillatoriales	1117|Cyanobacteria	MQ	PFAM Collagen-binding surface protein Cna-like, B-type domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind,SdrD_B
CMS2_k127_6530720_22	1198114.AciX9_2492	1.167e-48	204.0	COG4932@1|root,COG4932@2|Bacteria,3Y8E2@57723|Acidobacteria	57723|Acidobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS2_k127_6530720_13	498211.CJA_0016	8.746e-79	304.0	COG1361@1|root,COG2372@1|root,COG4733@1|root,COG1361@2|Bacteria,COG2372@2|Bacteria,COG4733@2|Bacteria,1N837@1224|Proteobacteria,1RZXI@1236|Gammaproteobacteria,1FI0F@10|Cellvibrio	1236|Gammaproteobacteria	M	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6530720_29	338966.Ppro_0645	2.075e-35	144.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,42S9X@68525|delta/epsilon subdivisions,2WNTZ@28221|Deltaproteobacteria,43SI1@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
CMS2_k127_6530720_2	1047013.AQSP01000045_gene110	2.155e-160	517.0	COG0215@1|root,COG0215@2|Bacteria,2NNP0@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2001065	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECUMN_1333.ECUMN_0566,iJN746.PP_2905,iNJ661.Rv2130c	DALR_2,tRNA-synt_1e,tRNA-synt_1g
CMS2_k127_6530720_18	1033810.HLPCO_000335	6.26e-64	232.0	COG0635@1|root,COG0635@2|Bacteria,2NP4Y@2323|unclassified Bacteria	2|Bacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS2_k127_6530720_30	944480.ATUV01000001_gene659	1.359e-32	132.0	COG1321@1|root,COG1321@2|Bacteria,1RHIK@1224|Proteobacteria,42SAD@68525|delta/epsilon subdivisions,2X6HJ@28221|Deltaproteobacteria,2M76C@213113|Desulfurellales	28221|Deltaproteobacteria	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
CMS2_k127_6530720_14	1121918.ARWE01000001_gene2035	7.814e-72	258.0	COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria,43TNQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
CMS2_k127_6530720_21	443143.GM18_3705	1.732e-53	196.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,42S7E@68525|delta/epsilon subdivisions,2WKJ0@28221|Deltaproteobacteria,43SDP@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	ycgM	-	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
CMS2_k127_6530720_16	517418.Ctha_0073	3.195e-68	237.0	COG0778@1|root,COG0778@2|Bacteria,1FE0V@1090|Chlorobi	1090|Chlorobi	C	PFAM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS2_k127_6530720_35	933801.Ahos_1202	1.339e-20	103.0	COG1208@1|root,arCOG00666@2157|Archaea,2XPX1@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase hexapeptide repeat containing protein	-	-	2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
CMS2_k127_6530720_32	1382359.JIAL01000001_gene2092	3.222e-27	118.0	COG1437@1|root,COG1437@2|Bacteria,3Y4V3@57723|Acidobacteria,2JJIG@204432|Acidobacteriia	204432|Acidobacteriia	F	CYTH	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
CMS2_k127_6530720_23	289377.HL41_08900	1.079e-44	174.0	COG0142@1|root,COG0142@2|Bacteria,2GGY1@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
CMS2_k127_6545199_77	661478.OP10G_3342	0.0002541	53.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
CMS2_k127_6545199_45	886379.AEWI01000022_gene192	3.984e-50	181.0	COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes,2FYEV@200643|Bacteroidia,3XKTU@558415|Marinilabiliaceae	976|Bacteroidetes	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
CMS2_k127_6545199_58	1499967.BAYZ01000076_gene842	1.509e-29	136.0	COG0457@1|root,COG0457@2|Bacteria,2NQJ6@2323|unclassified Bacteria	2|Bacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
CMS2_k127_6545199_47	1453505.JASY01000010_gene3987	1.447e-47	190.0	COG2333@1|root,COG2333@2|Bacteria,4NMP4@976|Bacteroidetes,1I17N@117743|Flavobacteriia,2NSH6@237|Flavobacterium	976|Bacteroidetes	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_6545199_65	880073.Calab_0444	1.721e-14	79.0	2E1HF@1|root,32WVJ@2|Bacteria,2NRFV@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3996
CMS2_k127_6545199_56	1047013.AQSP01000079_gene2043	4.306e-35	143.0	COG0810@1|root,COG0810@2|Bacteria,2NQ1D@2323|unclassified Bacteria	2|Bacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,TonB_C
CMS2_k127_6545199_66	598659.NAMH_1229	1.088e-13	74.0	COG1146@1|root,COG1146@2|Bacteria,1NJJD@1224|Proteobacteria,42TVE@68525|delta/epsilon subdivisions,2YPUN@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	2-oxoglutarate acceptor oxidoreductase	oorD	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7
CMS2_k127_6545199_18	338966.Ppro_2325	3.919e-115	382.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,43TR6@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
CMS2_k127_6545199_27	306263.Cla_0815	2.138e-88	300.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2YMMW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Oxidoreductase	oorB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
CMS2_k127_6545199_52	694431.DESACE_05225	4.944e-41	158.0	COG1014@1|root,COG1014@2|Bacteria,1N53C@1224|Proteobacteria,42S8J@68525|delta/epsilon subdivisions,2WQ37@28221|Deltaproteobacteria,2M6SG@213113|Desulfurellales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
CMS2_k127_6545199_5	470145.BACCOP_00826	1.342e-203	641.0	COG0162@1|root,COG0162@2|Bacteria,4NF19@976|Bacteroidetes,2FN0B@200643|Bacteroidia,4AMZF@815|Bacteroidaceae	976|Bacteroidetes	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
CMS2_k127_6545199_12	1121015.N789_06345	6.057e-149	497.0	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria,1X4WG@135614|Xanthomonadales	135614|Xanthomonadales	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_6545199_31	469382.Hbor_06850	1.035e-85	292.0	COG1226@1|root,arCOG01964@2157|Archaea,2XW00@28890|Euryarchaeota,23TV4@183963|Halobacteria	183963|Halobacteria	P	COG1226 Kef-type K transport systems	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2
CMS2_k127_6545199_8	517417.Cpar_1002	4.45e-173	572.0	COG0433@1|root,COG1340@1|root,COG0433@2|Bacteria,COG1340@2|Bacteria,1FEIF@1090|Chlorobi	1090|Chlorobi	S	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF87
CMS2_k127_6545199_36	1547445.LO80_04160	3.327e-76	268.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,45ZQB@72273|Thiotrichales	72273|Thiotrichales	E	Belongs to the peptidase S33 family	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
CMS2_k127_6545199_70	1047013.AQSP01000058_gene2028	1.076e-09	70.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,TolB_like
CMS2_k127_6545199_78	1121859.KB890744_gene677	0.000419	52.0	COG3391@1|root,COG3391@2|Bacteria,4PMW1@976|Bacteroidetes	976|Bacteroidetes	S	6-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128
CMS2_k127_6545199_54	1158318.ATXC01000001_gene53	1.303e-36	157.0	COG0666@1|root,COG0666@2|Bacteria,2G4XK@200783|Aquificae	200783|Aquificae	S	Ankyrin repeats (3 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_4,Ank_5
CMS2_k127_6545199_41	1047013.AQSP01000051_gene2576	2.831e-61	232.0	COG2220@1|root,COG2220@2|Bacteria,2NRBH@2323|unclassified Bacteria	2|Bacteria	S	Beta-lactamase superfamily domain	folD4	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CMS2_k127_6545199_19	877455.Metbo_1208	1.765e-113	375.0	COG0476@1|root,arCOG09483@1|root,arCOG01676@2157|Archaea,arCOG09483@2157|Archaea,2XTYV@28890|Euryarchaeota	28890|Euryarchaeota	H	UBA THIF-type NAD FAD binding protein	-	-	2.7.7.73,2.7.7.80	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	TBP,ThiF
CMS2_k127_6545199_37	935948.KE386494_gene960	1.681e-71	250.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,42FCT@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM PP-loop domain protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase,QueC
CMS2_k127_6545199_22	935948.KE386495_gene2116	1.313e-102	345.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,42F6N@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
CMS2_k127_6545199_3	765952.PUV_14580	1.638e-307	954.0	COG0365@1|root,COG0365@2|Bacteria,2JFRM@204428|Chlamydiae	204428|Chlamydiae	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
CMS2_k127_6545199_7	1121451.DESAM_21610	4.652e-174	554.0	COG2223@1|root,COG2223@2|Bacteria,1MWC7@1224|Proteobacteria,42P53@68525|delta/epsilon subdivisions,2WJ2U@28221|Deltaproteobacteria,2MAG1@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
CMS2_k127_6545199_43	324925.Ppha_0671	1.381e-55	209.0	COG3074@1|root,COG3074@2|Bacteria,1FFHR@1090|Chlorobi	1090|Chlorobi	D	FtsZ-dependent cytokinesis	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6545199_30	1047013.AQSP01000090_gene667	1.664e-86	296.0	COG0515@1|root,COG0515@2|Bacteria,2NPFQ@2323|unclassified Bacteria	2|Bacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_6545199_63	908340.HMPREF9406_1956	1.933e-17	91.0	COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia,36DGZ@31979|Clostridiaceae	186801|Clostridia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
CMS2_k127_6545199_20	335543.Sfum_1756	3.143e-108	361.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,2MQA6@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
CMS2_k127_6545199_6	639282.DEFDS_2114	2.478e-175	568.0	COG0443@1|root,COG0443@2|Bacteria,2GEXS@200930|Deferribacteres	200930|Deferribacteres	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
CMS2_k127_6545199_60	1047013.AQSP01000090_gene664	1.924e-29	127.0	COG0576@1|root,COG0576@2|Bacteria,2NPSS@2323|unclassified Bacteria	2|Bacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009628,GO:0009986,GO:0009987,GO:0009991,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030246,GO:0030247,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071496,GO:0071840,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
CMS2_k127_6545199_55	1047013.AQSP01000077_gene2278	2.184e-36	151.0	COG1420@1|root,COG1420@2|Bacteria,2NPAK@2323|unclassified Bacteria	2|Bacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA,HrcA_DNA-bdg
CMS2_k127_6545199_40	1121904.ARBP01000003_gene6533	8.285e-63	233.0	COG0400@1|root,COG0400@2|Bacteria,4NJ8E@976|Bacteroidetes	976|Bacteroidetes	S	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6545199_9	1111069.TCCBUS3UF1_4090	3.033e-170	544.0	COG0427@1|root,COG0427@2|Bacteria,1WJIT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Acetyl-CoA hydrolase/transferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
CMS2_k127_6545199_25	751945.Theos_1593	2.302e-89	308.0	COG0686@1|root,COG0686@2|Bacteria,1WIYT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
CMS2_k127_6545199_14	289376.THEYE_A0567	2.079e-135	441.0	COG1960@1|root,COG1960@2|Bacteria,3J13U@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS2_k127_6545199_33	697303.Thewi_0615	3.466e-80	275.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,42EVN@68295|Thermoanaerobacterales	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS2_k127_6545199_21	765952.PUV_22450	3.382e-104	353.0	COG1250@1|root,COG1250@2|Bacteria,2JFTQ@204428|Chlamydiae	204428|Chlamydiae	C	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N
CMS2_k127_6545199_15	765952.PUV_22440	4.774e-130	427.0	COG0183@1|root,COG0183@2|Bacteria,2JFTV@204428|Chlamydiae	204428|Chlamydiae	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C
CMS2_k127_6545199_49	311424.DhcVS_549	9.584e-47	174.0	COG0701@1|root,COG0701@2|Bacteria,2GAP3@200795|Chloroflexi,34CXR@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
CMS2_k127_6545199_16	1047013.AQSP01000133_gene2134	1.896e-125	409.0	COG1940@1|root,COG1940@2|Bacteria,2NPRP@2323|unclassified Bacteria	2|Bacteria	GK	ROK family	nagK	GO:0003674,GO:0003824,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006040,GO:0006044,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045127,GO:0046835,GO:0071704,GO:1901071,GO:1901135	2.7.1.2,2.7.1.4,2.7.1.59	ko:K00845,ko:K00847,ko:K00884	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R00760,R00867,R01201,R01600,R01786,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_1211,iECSE_1348.ECSE_0415,iEcHS_1320.EcHS_A0462,iEcHS_1320.EcHS_A1241,iEcolC_1368.EcolC_2482,iPC815.YPO3211,iS_1188.S0338,iYL1228.KPN_00337	ROK
CMS2_k127_6545199_68	1121115.AXVN01000109_gene2349	3.885e-10	65.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,3Y1R1@572511|Blautia	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
CMS2_k127_6545199_50	373903.Hore_08230	3.091e-42	179.0	COG0823@1|root,COG0823@2|Bacteria,1UTUZ@1239|Firmicutes,254F5@186801|Clostridia,3WBZM@53433|Halanaerobiales	186801|Clostridia	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6545199_17	880073.Calab_1650	6.173e-125	407.0	COG0492@1|root,COG0492@2|Bacteria,2NNS7@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2,Thioredoxin
CMS2_k127_6545199_34	1047013.AQSP01000073_gene1098	7.806e-80	273.0	COG1611@1|root,COG1611@2|Bacteria,2NP7M@2323|unclassified Bacteria	2|Bacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS2_k127_6545199_67	316067.Geob_1936	6.097e-12	79.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42P4R@68525|delta/epsilon subdivisions	1224|Proteobacteria	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
CMS2_k127_6545199_57	933262.AXAM01000017_gene3110	5.513e-34	134.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,42RDZ@68525|delta/epsilon subdivisions,2WQ4Z@28221|Deltaproteobacteria,2MK4R@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K06879,ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
CMS2_k127_6545199_28	1047013.AQSP01000140_gene2463	1.853e-87	302.0	COG0438@1|root,COG0438@2|Bacteria,2NQE7@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
CMS2_k127_6545199_23	1047013.AQSP01000140_gene2464	2.52e-94	322.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
CMS2_k127_6545199_48	1121447.JONL01000001_gene503	4.198e-47	185.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42MMF@68525|delta/epsilon subdivisions,2WJ1F@28221|Deltaproteobacteria,2M8PG@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
CMS2_k127_6545199_42	926567.TheveDRAFT_0308	4.869e-60	214.0	COG1802@1|root,COG1802@2|Bacteria,3TAH7@508458|Synergistetes	508458|Synergistetes	K	SMART regulatory protein GntR HTH	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS2_k127_6545199_35	1499967.BAYZ01000105_gene3488	1.669e-79	273.0	COG1180@1|root,COG1180@2|Bacteria	2|Bacteria	C	glycyl-radical enzyme activating activity	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
CMS2_k127_6545199_2	1499967.BAYZ01000105_gene3489	0.0	1184.0	COG1882@1|root,COG1882@2|Bacteria,2NQDK@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate formate lyase-like	pflD	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
CMS2_k127_6545199_24	1347392.CCEZ01000049_gene1641	4.032e-94	319.0	COG2423@1|root,COG2423@2|Bacteria,1TPHM@1239|Firmicutes,24DP8@186801|Clostridia,36FYU@31979|Clostridiaceae	186801|Clostridia	E	ornithine cyclodeaminase mu-crystallin	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
CMS2_k127_6545199_13	1047013.AQSP01000119_gene1312	5.481e-145	467.0	COG3938@1|root,COG3938@2|Bacteria,2NQES@2323|unclassified Bacteria	2|Bacteria	E	Proline racemase	-	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016855,GO:0018112,GO:0019752,GO:0036361,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047661,GO:0050346,GO:0071704,GO:1901564	5.1.1.4	ko:K01777	ko00330,ko01100,map00330,map01100	-	R01255	RC00479	ko00000,ko00001,ko01000	-	-	-	Pro_racemase
CMS2_k127_6545199_71	411470.RUMGNA_01739	1.656e-09	63.0	COG2207@1|root,COG2207@2|Bacteria,1TQD7@1239|Firmicutes,24DSW@186801|Clostridia,3Y1J2@572511|Blautia	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS2_k127_6545199_10	1232437.KL661986_gene3679	4.868e-151	514.0	COG3829@1|root,COG3852@1|root,COG4564@1|root,COG3829@2|Bacteria,COG3852@2|Bacteria,COG4564@2|Bacteria,1QW3X@1224|Proteobacteria,42YCI@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	PAS fold	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE
CMS2_k127_6545199_53	158190.SpiGrapes_2575	4.603e-37	162.0	COG2199@1|root,COG2206@1|root,COG4936@1|root,COG2199@2|Bacteria,COG2206@2|Bacteria,COG4936@2|Bacteria,2J5UD@203691|Spirochaetes	203691|Spirochaetes	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HAMP,HD,HD_5
CMS2_k127_6545199_61	1122225.AULQ01000006_gene1099	9.562e-26	108.0	COG1359@1|root,COG1359@2|Bacteria,4NSV0@976|Bacteroidetes,1I40Y@117743|Flavobacteriia	976|Bacteroidetes	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
CMS2_k127_6545199_44	331869.BAL199_29987	5.974e-52	188.0	COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,2U99S@28211|Alphaproteobacteria,4BS1J@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative zinc- or iron-chelating domain	MA20_15575	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	CxxCxxCC
CMS2_k127_6545199_38	1047013.AQSP01000047_gene2586	4.524e-71	245.0	COG0302@1|root,COG0302@2|Bacteria,2NPE9@2323|unclassified Bacteria	2|Bacteria	H	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659	2.7.6.3,3.5.4.16	ko:K00950,ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R03503,R04639,R05046,R05048	RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0928,iNJ661.Rv3609c	GTP_cyclohydroI
CMS2_k127_6545199_59	1231241.Mc24_09164	1.864e-29	121.0	COG0745@1|root,COG0745@2|Bacteria,2GDAM@200918|Thermotogae	200918|Thermotogae	T	PFAM response regulator receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
CMS2_k127_6545199_0	1382359.JIAL01000001_gene2922	0.0	1607.0	COG0086@1|root,COG0086@2|Bacteria,3Y2FZ@57723|Acidobacteria,2JIW0@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
CMS2_k127_6545199_1	639282.DEFDS_1779	0.0	1277.0	COG0085@1|root,COG0085@2|Bacteria,2GEW9@200930|Deferribacteres	200930|Deferribacteres	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
CMS2_k127_6545199_51	1047013.AQSP01000087_gene1644	3.119e-41	155.0	COG0222@1|root,COG0222@2|Bacteria,2NPJ4@2323|unclassified Bacteria	2|Bacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
CMS2_k127_6545199_62	1232437.KL662045_gene2152	5.153e-23	105.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,42R1J@68525|delta/epsilon subdivisions,2WQE8@28221|Deltaproteobacteria,2MKCS@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
CMS2_k127_6545199_32	436114.SYO3AOP1_0301	1.383e-81	278.0	COG0081@1|root,COG0081@2|Bacteria,2G3UI@200783|Aquificae	200783|Aquificae	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
CMS2_k127_6545199_46	1158338.JNLJ01000001_gene510	7.47e-48	175.0	COG0080@1|root,COG0080@2|Bacteria,2G41D@200783|Aquificae	200783|Aquificae	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
CMS2_k127_6545199_39	1047013.AQSP01000086_gene2011	5.86e-66	229.0	COG0250@1|root,COG0250@2|Bacteria,2NPAP@2323|unclassified Bacteria	2|Bacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
CMS2_k127_6545199_72	123214.PERMA_1183	1.271e-07	55.0	COG0690@1|root,COG0690@2|Bacteria,2G4D3@200783|Aquificae	200783|Aquificae	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
CMS2_k127_6545199_74	1122169.AREN01000056_gene2019	9.069e-06	47.0	COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria,1JECV@118969|Legionellales	118969|Legionellales	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
CMS2_k127_6545199_64	354242.CJJ81176_0500	1.012e-16	80.0	COG0267@1|root,COG0267@2|Bacteria,1NJ67@1224|Proteobacteria,42V5X@68525|delta/epsilon subdivisions,2YQ8V@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
CMS2_k127_6545199_4	1047013.AQSP01000086_gene2010	7.564e-204	639.0	COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria	2|Bacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
CMS2_k127_6545199_26	240016.ABIZ01000001_gene3468	1.266e-88	300.0	COG0179@1|root,COG0179@2|Bacteria,46SDD@74201|Verrucomicrobia,2IUC8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
CMS2_k127_6545199_11	1123242.JH636435_gene3150	3.713e-150	518.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,2IXFD@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
CMS2_k127_6545199_29	517417.Cpar_1060	6.227e-87	293.0	COG0846@1|root,COG0846@2|Bacteria,1FEUB@1090|Chlorobi	1090|Chlorobi	K	Silent information regulator protein Sir2	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
CMS2_k127_6553911_1	756067.MicvaDRAFT_0614	2.982e-06	55.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H7F4@1150|Oscillatoriales	1117|Cyanobacteria	Q	Amino acid adenylation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,TPR_1,TPR_8,Thioesterase
CMS2_k127_6553911_0	768706.Desor_3736	3.396e-240	783.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,260Y0@186807|Peptococcaceae	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	ko:K15664	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_6593754_14	795359.TOPB45_0665	2.736e-57	217.0	COG2204@1|root,COG2204@2|Bacteria,2GHIR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_6593754_10	857293.CAAU_0564	1.98e-97	329.0	COG4448@1|root,COG4448@2|Bacteria,1TRWI@1239|Firmicutes,24CUE@186801|Clostridia,36GGQ@31979|Clostridiaceae	186801|Clostridia	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
CMS2_k127_6593754_16	289376.THEYE_A1005	1.158e-45	181.0	COG1906@1|root,COG1906@2|Bacteria	2|Bacteria	C	membrane	-	-	-	ko:K09133	-	-	-	-	ko00000	-	-	-	DUF401
CMS2_k127_6593754_26	204669.Acid345_1473	4.686e-07	63.0	COG4796@1|root,COG4796@2|Bacteria,3Y98D@57723|Acidobacteria	57723|Acidobacteria	U	Secretin and TonB N terminus short domain	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,Secretin,Secretin_N
CMS2_k127_6593754_29	1123502.AQXD01000001_gene610	2.458e-06	61.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1X3SF@135614|Xanthomonadales	135614|Xanthomonadales	U	Type II secretory pathway, component HofQ	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
CMS2_k127_6593754_21	6211.A0A087VYH8	3.061e-21	110.0	COG0666@1|root,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3BAXI@33208|Metazoa	33208|Metazoa	M	Ankyrin 1, erythrocytic	-	-	-	ko:K10380,ko:K15502,ko:K15503	ko04624,ko05205,map04624,map05205	-	-	-	ko00000,ko00001,ko01009,ko03400,ko04812	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5
CMS2_k127_6593754_30	1121285.AUFK01000009_gene1148	0.0001718	54.0	COG4733@1|root,COG4733@2|Bacteria,4PKYK@976|Bacteroidetes,1IJHK@117743|Flavobacteriia,3ZQWF@59732|Chryseobacterium	976|Bacteroidetes	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Pec_lyase_C,fn3
CMS2_k127_6593754_8	483219.LILAB_22370	6.09e-105	357.0	COG3591@1|root,COG3591@2|Bacteria,1QDPR@1224|Proteobacteria,434U5@68525|delta/epsilon subdivisions,2X90W@28221|Deltaproteobacteria,2Z1CH@29|Myxococcales	28221|Deltaproteobacteria	E	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	PPC,Trypsin_2
CMS2_k127_6593754_25	1121904.ARBP01000007_gene3002	1.04e-08	62.0	2DS6Y@1|root,33EU1@2|Bacteria,4P8GT@976|Bacteroidetes	976|Bacteroidetes	S	Sporulation protein YtfJ (Spore_YtfJ)	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
CMS2_k127_6593754_18	290400.Jann_4122	1.867e-41	173.0	2BYY4@1|root,2Z80Y@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4438)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4438
CMS2_k127_6593754_13	373903.Hore_08360	9.694e-63	239.0	2BYY4@1|root,2Z80Y@2|Bacteria,1TSXF@1239|Firmicutes,24B6G@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4438)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4438
CMS2_k127_6593754_11	391587.KAOT1_15528	2.126e-93	316.0	2DKVM@1|root,30HIR@2|Bacteria,4NPPK@976|Bacteroidetes,1I1YI@117743|Flavobacteriia	976|Bacteroidetes	S	Lantibiotic biosynthesis dehydratase C-term	-	-	-	-	-	-	-	-	-	-	-	-	Lant_dehydr_C
CMS2_k127_6593754_0	391587.KAOT1_15523	7.59e-232	739.0	2C4IS@1|root,2Z81U@2|Bacteria,4NETW@976|Bacteroidetes,1HZZP@117743|Flavobacteriia	976|Bacteroidetes	S	Lantibiotic dehydratase, C terminus	-	-	-	ko:K20483	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001	-	-	-	Lant_dehydr_C,Lant_dehydr_N
CMS2_k127_6593754_15	1267535.KB906767_gene3063	2.248e-48	184.0	COG0681@1|root,COG0681@2|Bacteria,3Y40D@57723|Acidobacteria,2JHWM@204432|Acidobacteriia	204432|Acidobacteriia	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
CMS2_k127_6593754_24	580340.Tlie_1397	8.372e-09	64.0	COG0235@1|root,COG0235@2|Bacteria,3TATG@508458|Synergistetes	508458|Synergistetes	G	PFAM class II aldolase adducin family protein	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
CMS2_k127_6593754_12	1499967.BAYZ01000159_gene538	2.268e-71	254.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
CMS2_k127_6593754_22	1423321.AS29_14160	4.499e-17	86.0	COG1725@1|root,COG1725@2|Bacteria,1VFD0@1239|Firmicutes,4HNIT@91061|Bacilli,1ZGQV@1386|Bacillus	91061|Bacilli	K	GntR family transcriptional regulator	ytrA	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS2_k127_6593754_20	887325.HMPREF0381_2506	4.561e-23	109.0	COG1131@1|root,COG1131@2|Bacteria,1TPQW@1239|Firmicutes,248F7@186801|Clostridia,1HVI6@1164882|Lachnoanaerobaculum	186801|Clostridia	V	ABC transporter	ytrB	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_6593754_27	483219.LILAB_30325	1.474e-06	61.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,HATPase_c,HTH_Crp_2,HisKA,HisKA_3,PAS,Response_reg
CMS2_k127_6593754_3	1047013.AQSP01000114_gene684	4.944e-194	622.0	COG1629@1|root,COG2304@1|root,COG1629@2|Bacteria,COG2304@2|Bacteria,2NQ3W@2323|unclassified Bacteria	2|Bacteria	P	von Willebrand factor type A domain	yfbK	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	CarbopepD_reg_2,DUF3520,Plug,VWA,vWF_A
CMS2_k127_6593754_19	880073.Calab_2740	2.147e-28	116.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
CMS2_k127_6593754_7	1047013.AQSP01000104_gene1417	1.263e-109	360.0	COG1136@1|root,COG1136@2|Bacteria,2NQWU@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_6593754_6	1047013.AQSP01000104_gene1418	8.731e-138	451.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS2_k127_6593754_2	1047013.AQSP01000104_gene1419	9.138e-199	628.0	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_6593754_5	1047013.AQSP01000104_gene1411	9.818e-150	487.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_8
CMS2_k127_6593754_23	1121459.AQXE01000006_gene171	4.065e-16	83.0	COG0727@1|root,COG0727@2|Bacteria,1Q96V@1224|Proteobacteria,4363B@68525|delta/epsilon subdivisions,2X9F9@28221|Deltaproteobacteria,2MCT3@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
CMS2_k127_6593754_9	1403313.AXBR01000007_gene217	9.79e-100	331.0	COG1834@1|root,COG1834@2|Bacteria,1TRPV@1239|Firmicutes,4H9YU@91061|Bacilli	91061|Bacilli	E	Amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
CMS2_k127_6593754_4	1123009.AUID01000010_gene544	1.506e-180	578.0	COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,26A0G@186813|unclassified Clostridiales	186801|Clostridia	E	Sodium:alanine symporter family	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
CMS2_k127_6593754_17	1047013.AQSP01000088_gene1629	2.553e-43	170.0	COG4219@1|root,COG4219@2|Bacteria,2NR11@2323|unclassified Bacteria	2|Bacteria	KT	Peptidase M56	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	DUF4367,TonB_C
CMS2_k127_6593754_1	493475.GARC_5358	1.558e-204	668.0	COG3345@1|root,COG3345@2|Bacteria,1MW78@1224|Proteobacteria,1RRKC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	enterotoxin	ast	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6618351_6	243232.MJ_1612	3.002e-116	386.0	COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota,23PZZ@183939|Methanococci	183939|Methanococci	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
CMS2_k127_6618351_14	933262.AXAM01000022_gene3217	2.772e-32	138.0	COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,42QRA@68525|delta/epsilon subdivisions,2WN1V@28221|Deltaproteobacteria,2MK22@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
CMS2_k127_6618351_17	1341157.RF007C_05045	1.341e-17	93.0	2C4AE@1|root,33RF7@2|Bacteria,1VSJ4@1239|Firmicutes,24WJT@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6618351_24	760568.Desku_2321	1.25e-06	59.0	2ABEA@1|root,310V2@2|Bacteria,1VZ0H@1239|Firmicutes,2534K@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6618351_9	667014.Thein_1651	7.072e-60	217.0	COG1237@1|root,COG1237@2|Bacteria,2GHSY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Beta-lactamase superfamily domain	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
CMS2_k127_6618351_19	1123284.KB899045_gene2531	7.04e-11	65.0	2C5U6@1|root,330NX@2|Bacteria,1VGSI@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6618351_15	1047013.AQSP01000139_gene2362	1.439e-19	93.0	COG1555@1|root,COG1555@2|Bacteria,2NQ6P@2323|unclassified Bacteria	2|Bacteria	L	Helix-hairpin-helix motif	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
CMS2_k127_6618351_4	1499967.BAYZ01000073_gene2046	9.989e-140	452.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_6618351_8	1449050.JNLE01000003_gene567	3.131e-61	220.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,36DZN@31979|Clostridiaceae	186801|Clostridia	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
CMS2_k127_6618351_5	211165.AJLN01000074_gene6347	1.248e-127	420.0	COG1106@1|root,COG1106@2|Bacteria,1G3K0@1117|Cyanobacteria	1117|Cyanobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K06926	-	-	-	-	ko00000	-	-	-	AAA_21
CMS2_k127_6618351_10	211165.AJLN01000074_gene6348	3.619e-58	211.0	29Z3H@1|root,30M12@2|Bacteria,1GKNQ@1117|Cyanobacteria,1JMGR@1189|Stigonemataceae	1117|Cyanobacteria	S	RloB-like protein	-	-	-	-	-	-	-	-	-	-	-	-	RloB
CMS2_k127_6618351_12	1158762.KB898039_gene1707	2.059e-34	135.0	COG0745@1|root,COG0745@2|Bacteria,1MZAS@1224|Proteobacteria,1S9XI@1236|Gammaproteobacteria,1WYTZ@135613|Chromatiales	135613|Chromatiales	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_6618351_23	1123514.KB905902_gene221	3.424e-08	64.0	COG2199@1|root,COG3706@2|Bacteria,1MVWM@1224|Proteobacteria,1RR1M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HDOD,Hpt,Response_reg
CMS2_k127_6618351_18	748449.Halha_0820	3.306e-16	89.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,3WAJ5@53433|Halanaerobiales	186801|Clostridia	K	PFAM response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_6618351_1	1047013.AQSP01000134_gene1351	6.47e-297	926.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS2_k127_6618351_2	1047013.AQSP01000134_gene1350	1.596e-265	829.0	COG2866@1|root,COG2866@2|Bacteria,2NPI7@2323|unclassified Bacteria	2|Bacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS2_k127_6618351_25	1347393.HG726028_gene2236	0.0006984	51.0	2DQW7@1|root,33919@2|Bacteria,4PNW8@976|Bacteroidetes,2G0ZF@200643|Bacteroidia	976|Bacteroidetes	S	Domain of unknown function (DUF4934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128
CMS2_k127_6618351_16	580327.Tthe_2254	3.989e-19	92.0	COG1487@1|root,COG1487@2|Bacteria,1VNH4@1239|Firmicutes,24WP8@186801|Clostridia	186801|Clostridia	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_6618351_20	1189612.A33Q_1075	4.011e-09	59.0	2DTSM@1|root,33MH2@2|Bacteria,4P8U0@976|Bacteroidetes,47WWI@768503|Cytophagia	976|Bacteroidetes	S	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
CMS2_k127_6618351_0	742727.HMPREF9447_01783	7.598e-309	966.0	COG3533@1|root,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes,2FM1I@200643|Bacteroidia,4AKRG@815|Bacteroidaceae	976|Bacteroidetes	S	protein conserved in bacteria	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
CMS2_k127_6618351_3	2002.JOEQ01000003_gene2490	7.609e-143	459.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4EI60@85012|Streptosporangiales	201174|Actinobacteria	EK	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_6618351_7	1408473.JHXO01000004_gene1	6.173e-64	226.0	COG2249@1|root,COG2249@2|Bacteria	2|Bacteria	K	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_2
CMS2_k127_6618351_13	526218.Sterm_0780	1.057e-32	134.0	COG0655@1|root,COG0655@2|Bacteria,37B47@32066|Fusobacteria	32066|Fusobacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS2_k127_6618351_11	443143.GM18_3862	2.232e-49	177.0	COG1917@1|root,COG1917@2|Bacteria,1MZD8@1224|Proteobacteria,42W0P@68525|delta/epsilon subdivisions,2WRDR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS2_k127_6630462_1	588581.Cpap_3269	2.267e-176	576.0	COG0331@1|root,COG2070@1|root,COG0331@2|Bacteria,COG2070@2|Bacteria,1TPB7@1239|Firmicutes,247UF@186801|Clostridia,3WGWD@541000|Ruminococcaceae	186801|Clostridia	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
CMS2_k127_6630462_3	1042163.BRLA_c022240	3.074e-71	267.0	COG0491@1|root,COG0491@2|Bacteria,1V5TI@1239|Firmicutes,4HH95@91061|Bacilli,2756G@186822|Paenibacillaceae	91061|Bacilli	S	Metallo-beta-lactamase superfamily	pksB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
CMS2_k127_6630462_0	1499967.BAYZ01000136_gene20	3.328e-247	786.0	COG1033@1|root,COG1033@2|Bacteria,2NQ2I@2323|unclassified Bacteria	2|Bacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS2_k127_6630462_2	586413.CCDL010000001_gene1218	1.556e-95	326.0	COG1680@1|root,COG1680@2|Bacteria,1V3KP@1239|Firmicutes,4IDK5@91061|Bacilli,23KW4@182709|Oceanobacillus	91061|Bacilli	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_6630462_4	1304872.JAGC01000009_gene868	6.536e-53	194.0	COG0500@1|root,COG2226@2|Bacteria,1N9E8@1224|Proteobacteria,42WJE@68525|delta/epsilon subdivisions,2WS0T@28221|Deltaproteobacteria,2MA1U@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS2_k127_6630462_5	1146883.BLASA_2513	8.548e-18	90.0	COG0346@1|root,COG0346@2|Bacteria,2IRPZ@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
CMS2_k127_675775_14	439235.Dalk_2288	4.716e-18	93.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,2MPW6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4150,RHS,RHS_repeat,Transglut_core
CMS2_k127_675775_7	760192.Halhy_1128	1.234e-47	190.0	COG3209@1|root,COG3209@2|Bacteria,4NFUE@976|Bacteroidetes,1INSI@117747|Sphingobacteriia	976|Bacteroidetes	M	COG3209 Rhs family protein	rhsA	-	-	-	-	-	-	-	-	-	-	-	RHS,RHS_repeat
CMS2_k127_675775_15	1121352.JHZP01000001_gene551	2.235e-12	74.0	COG2849@1|root,COG2849@2|Bacteria,1RJZH@1224|Proteobacteria,2VT1T@28216|Betaproteobacteria,2KRHY@206351|Neisseriales	206351|Neisseriales	S	MORN repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2
CMS2_k127_675775_20	439235.Dalk_2132	0.0001106	54.0	COG3291@1|root,COG3292@1|root,COG3291@2|Bacteria,COG3292@2|Bacteria,1QU1S@1224|Proteobacteria,42WTY@68525|delta/epsilon subdivisions,2WSR0@28221|Deltaproteobacteria,2MNQR@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,PKD,Peptidase_C13,Reg_prop
CMS2_k127_675775_9	929558.SMGD1_1196	7.713e-45	188.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,42UA0@68525|delta/epsilon subdivisions	1224|Proteobacteria	U	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,PD40,TPR_10,TPR_12,TPR_16,TPR_7,TPR_8
CMS2_k127_675775_18	1123355.JHYO01000026_gene260	1.18e-09	72.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria,36XUA@31993|Methylocystaceae	28211|Alphaproteobacteria	S	TPR repeat	MA20_42300	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
CMS2_k127_675775_6	1173024.KI912148_gene3573	3.013e-59	224.0	COG1357@1|root,COG1672@1|root,COG1357@2|Bacteria,COG1672@2|Bacteria,1GCFZ@1117|Cyanobacteria,1JK9S@1189|Stigonemataceae	1117|Cyanobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
CMS2_k127_675775_11	331113.SNE_A06290	1.209e-35	143.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	2.7.4.29,3.6.1.27	ko:K19302,ko:K19803	ko00550,map00550	-	R05627,R11186	RC00002	ko00000,ko00001,ko01000,ko01005,ko01011	-	-	-	PAP2
CMS2_k127_675775_10	313606.M23134_00160	2.842e-44	168.0	COG4319@1|root,COG4319@2|Bacteria,4PKP4@976|Bacteroidetes,47Q9F@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF2911)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2911
CMS2_k127_675775_4	1273103.NM10_07494	8.552e-79	273.0	COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,4H1WW@909932|Negativicutes	909932|Negativicutes	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
CMS2_k127_675775_5	1047013.AQSP01000057_gene1926	9.184e-68	245.0	COG1253@1|root,COG1253@2|Bacteria,2NP9I@2323|unclassified Bacteria	2|Bacteria	S	Transporter associated domain	gldE	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
CMS2_k127_675775_12	243274.THEMA_03575	5.8e-34	136.0	COG0622@1|root,COG0622@2|Bacteria,2GD1H@200918|Thermotogae	200918|Thermotogae	S	TIGRFAM phosphodiesterase, MJ0936 family	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
CMS2_k127_675775_2	1121272.KB903249_gene1515	8.288e-199	650.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,2I9U6@201174|Actinobacteria,4DH83@85008|Micromonosporales	201174|Actinobacteria	O	Proprotein convertase P-domain	-	-	-	-	-	-	-	-	-	-	-	-	P_proprotein,Peptidase_S8
CMS2_k127_675775_17	1121904.ARBP01000036_gene2106	4.479e-11	77.0	COG1524@1|root,COG4099@1|root,COG4733@1|root,COG1524@2|Bacteria,COG4099@2|Bacteria,COG4733@2|Bacteria,4NK2V@976|Bacteroidetes	976|Bacteroidetes	O	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PA14,fn3
CMS2_k127_675775_0	398512.JQKC01000009_gene568	0.0	2286.0	COG1020@1|root,COG1020@2|Bacteria,1V12Q@1239|Firmicutes,24ER3@186801|Clostridia,3WNBS@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,PP-binding,QueC,Radical_SAM
CMS2_k127_675775_3	289376.THEYE_A1149	1.375e-81	284.0	COG1902@1|root,COG1902@2|Bacteria,3J14N@40117|Nitrospirae	40117|Nitrospirae	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
CMS2_k127_675775_1	1047013.AQSP01000133_gene2122	1.404e-278	864.0	COG2759@1|root,COG2759@2|Bacteria,2NP2R@2323|unclassified Bacteria	2|Bacteria	F	Formate--tetrahydrofolate ligase	fhs	GO:0000096,GO:0000097,GO:0000105,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006520,GO:0006547,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009108,GO:0009110,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0052803,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.5,3.5.4.9,6.3.4.3	ko:K00288,ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00141,M00377	R00943,R01220,R01655	RC00026,RC00111,RC00202,RC00578	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FTHFS
CMS2_k127_675775_16	515635.Dtur_0533	9.499e-12	67.0	COG0489@1|root,COG0489@2|Bacteria	2|Bacteria	D	protein tyrosine kinase activity	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
CMS2_k127_675775_13	1047013.AQSP01000081_gene96	4.222e-26	112.0	COG0489@1|root,COG0489@2|Bacteria,2NNX1@2323|unclassified Bacteria	2|Bacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
CMS2_k127_675775_19	880073.Calab_3139	8.35e-09	61.0	2DNMM@1|root,32Y53@2|Bacteria	2|Bacteria	S	Family of unknown function (DUF5320)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5320
CMS2_k127_6760416_0	394503.Ccel_2386	0.0	1066.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6760416_2	509191.AEDB02000067_gene916	3.888e-204	650.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_6760416_4	1047013.AQSP01000139_gene2323	2.47e-132	449.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_6760416_1	56110.Oscil6304_3229	6.396e-315	999.0	COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria	1117|Cyanobacteria	Q	Beta-ketoacyl synthase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_6760416_5	314225.ELI_11670	1.461e-67	237.0	COG0500@1|root,COG2226@2|Bacteria,1R439@1224|Proteobacteria,2U0N2@28211|Alphaproteobacteria,2K92J@204457|Sphingomonadales	204457|Sphingomonadales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_6760416_8	871968.DESME_04295	5.459e-29	123.0	COG0746@1|root,COG0746@2|Bacteria,1VA6T@1239|Firmicutes,24JG6@186801|Clostridia,262DJ@186807|Peptococcaceae	186801|Clostridia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS2_k127_6760416_7	1391646.AVSU01000100_gene3390	2.77e-45	173.0	COG1526@1|root,COG1526@2|Bacteria,1TU8R@1239|Firmicutes,24G61@186801|Clostridia,25SIK@186804|Peptostreptococcaceae	186801|Clostridia	C	FdhD/NarQ family	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
CMS2_k127_6760416_3	502025.Hoch_1667	5.824e-143	482.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,4381G@68525|delta/epsilon subdivisions,2X3BJ@28221|Deltaproteobacteria,2YV9W@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase propeptide and YPEB domain	-	-	3.4.24.26	ko:K01399	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS2_k127_6760416_6	1237149.C900_05552	3.486e-52	209.0	COG3227@1|root,COG3291@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,4NJK3@976|Bacteroidetes,47TYM@768503|Cytophagia	976|Bacteroidetes	E	Pregnancy-associated plasma protein-A	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_M43,fn3
CMS2_k127_6762390_0	1121396.KB892913_gene116	2.56e-141	459.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,42WI2@68525|delta/epsilon subdivisions,2WRPD@28221|Deltaproteobacteria,2MQ18@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Transposase zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
CMS2_k127_6762390_1	768706.Desor_2211	1.21e-15	79.0	COG4974@1|root,COG4974@2|Bacteria,1TR57@1239|Firmicutes,24ACW@186801|Clostridia,26128@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
CMS2_k127_6762390_2	398525.KB900701_gene486	2.302e-09	60.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,3JVM3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
CMS2_k127_68069_42	1249480.B649_01585	7.325e-26	110.0	COG4679@1|root,COG4679@2|Bacteria	1249480.B649_01585|-	K	PFAM Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_68069_3	1499967.BAYZ01000028_gene1332	4.372e-239	754.0	COG0737@1|root,COG0737@2|Bacteria,2NQIA@2323|unclassified Bacteria	2|Bacteria	F	5'-nucleotidase, C-terminal domain	cpdB	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
CMS2_k127_68069_16	1120973.AQXL01000133_gene1750	1.094e-125	415.0	COG1322@1|root,COG1322@2|Bacteria,1TPWI@1239|Firmicutes,4HE2N@91061|Bacilli	91061|Bacilli	S	RmuC domain protein	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
CMS2_k127_68069_18	443254.Marpi_1411	7.455e-117	386.0	COG1186@1|root,COG1186@2|Bacteria,2GCJ9@200918|Thermotogae	200918|Thermotogae	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CMS2_k127_68069_29	1499967.BAYZ01000074_gene2118	2.419e-61	226.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_68069_50	1395513.P343_11860	2.39e-11	74.0	COG3595@1|root,COG3595@2|Bacteria,1VATC@1239|Firmicutes,4HKW2@91061|Bacilli,26PWN@186821|Sporolactobacillaceae	91061|Bacilli	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS2_k127_68069_14	1047013.AQSP01000079_gene2039	3.231e-140	454.0	2C57D@1|root,2Z7RS@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2891
CMS2_k127_68069_21	1340493.JNIF01000003_gene4346	9.739e-98	329.0	COG1085@1|root,COG1085@2|Bacteria,3Y41K@57723|Acidobacteria	57723|Acidobacteria	C	Galactose-1-phosphate uridyl transferase, N-terminal domain	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
CMS2_k127_68069_43	273068.TTE1452	2.399e-24	106.0	COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,42H26@68295|Thermoanaerobacterales	186801|Clostridia	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
CMS2_k127_68069_13	1499967.BAYZ01000013_gene6445	3.329e-146	476.0	COG1748@1|root,COG1748@2|Bacteria,2NNZ1@2323|unclassified Bacteria	2|Bacteria	E	Saccharopine dehydrogenase C-terminal domain	lys2	-	1.5.1.10	ko:K00293	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R02315	RC00215,RC00225	ko00000,ko00001,ko00002,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
CMS2_k127_68069_11	1499967.BAYZ01000013_gene6446	6.139e-150	486.0	COG0686@1|root,COG0686@2|Bacteria,2NNTE@2323|unclassified Bacteria	2|Bacteria	E	Alanine dehydrogenase/PNT, N-terminal domain	sdh	-	1.5.1.7,1.5.1.8,1.5.1.9	ko:K00290,ko:K14157	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715,R00716,R02313	RC00215,RC00217,RC00225,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
CMS2_k127_68069_4	767817.Desgi_1166	4.156e-217	683.0	COG3259@1|root,COG3259@2|Bacteria,1UZNV@1239|Firmicutes,24F0H@186801|Clostridia,2644W@186807|Peptococcaceae	186801|Clostridia	C	Nickel-dependent hydrogenase	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
CMS2_k127_68069_17	429009.Adeg_2014	1.31e-118	391.0	COG1941@1|root,COG1941@2|Bacteria,1V21E@1239|Firmicutes,24GWD@186801|Clostridia,42HGR@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
CMS2_k127_68069_28	880073.Calab_3045	2.654e-63	220.0	COG1908@1|root,COG1908@2|Bacteria,2NPFI@2323|unclassified Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	bamF	-	1.8.98.5,1.8.98.6	ko:K14127,ko:K14128	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2083	Fer4,FlpD,HTH_5
CMS2_k127_68069_9	485915.Dret_0421	2.743e-158	517.0	COG1148@1|root,COG1148@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria,2M898@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,FlpD,Pyr_redox_2
CMS2_k127_68069_23	429009.Adeg_1077	3.38e-88	308.0	COG1150@1|root,COG1150@2|Bacteria,1TRAM@1239|Firmicutes,24CFA@186801|Clostridia,42HT9@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K16887	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17
CMS2_k127_68069_10	693661.Arcve_1567	3.344e-151	498.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	183980|Archaeoglobi	C	Heterodisulfide reductase subunit A and related polyferredoxins	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
CMS2_k127_68069_53	592029.DDD_3285	1.161e-07	64.0	COG4640@1|root,COG4640@2|Bacteria,4PNJT@976|Bacteroidetes,1IN04@117743|Flavobacteriia	976|Bacteroidetes	S	YARHG	-	-	-	-	-	-	-	-	-	-	-	-	YARHG
CMS2_k127_68069_25	1220534.B655_2427	4.352e-79	282.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,arCOG04001@1|root,arCOG02361@2157|Archaea,arCOG04001@2157|Archaea,arCOG06537@2157|Archaea,arCOG06918@2157|Archaea	2157|Archaea	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	BAT,GAF_2,GAF_3,HATPase_c,HTH_10,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9,PocR,Response_reg
CMS2_k127_68069_5	639282.DEFDS_1228	8.37e-213	672.0	COG4799@1|root,COG4799@2|Bacteria,2GEP0@200930|Deferribacteres	200930|Deferribacteres	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
CMS2_k127_68069_26	1191523.MROS_2742	6.263e-69	253.0	COG0439@1|root,COG0439@2|Bacteria	2|Bacteria	I	biotin carboxylase activity	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
CMS2_k127_68069_47	694431.DESACE_02120	5.775e-15	81.0	COG4770@1|root,COG4770@2|Bacteria,1RJYU@1224|Proteobacteria,42WT6@68525|delta/epsilon subdivisions,2WSN5@28221|Deltaproteobacteria,2M773@213113|Desulfurellales	28221|Deltaproteobacteria	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
CMS2_k127_68069_15	880073.Calab_1439	2.856e-128	421.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	mscS2	-	-	ko:K16053	-	-	-	-	ko00000,ko02000	1.A.23.4.5	-	-	MS_channel
CMS2_k127_68069_7	272134.KB731324_gene3214	8.003e-182	589.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1G1Q1@1117|Cyanobacteria,1H8JB@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3471,PD40,Peptidase_S9,Peptidase_S9_N
CMS2_k127_68069_1	926692.AZYG01000012_gene877	6.57e-257	818.0	COG1033@1|root,COG1033@2|Bacteria	2|Bacteria	S	growth of symbiont in host cell	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS2_k127_68069_20	203275.BFO_1607	4.454e-100	342.0	COG3103@1|root,COG3103@2|Bacteria,4NIB7@976|Bacteroidetes,2FQFE@200643|Bacteroidia,22X8V@171551|Porphyromonadaceae	976|Bacteroidetes	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_68069_24	643562.Daes_0570	1.658e-79	274.0	COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,42QPE@68525|delta/epsilon subdivisions,2WN39@28221|Deltaproteobacteria,2MBNK@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS2_k127_68069_39	1499967.BAYZ01000100_gene3451	2.661e-35	139.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR
CMS2_k127_68069_6	158189.SpiBuddy_2004	5.285e-198	630.0	COG0540@1|root,COG1781@1|root,COG0540@2|Bacteria,COG1781@2|Bacteria,2J5J0@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Aspartate ornithine carbamoyltransferase, carbamoyl-P binding	pyrB	-	2.1.3.2	ko:K00608,ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N,PyrI,PyrI_C
CMS2_k127_68069_41	880073.Calab_0283	6.781e-31	132.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS2_k127_68069_31	373994.Riv7116_5176	6.166e-58	211.0	COG0500@1|root,COG2226@2|Bacteria,1GC88@1117|Cyanobacteria,1HKZM@1161|Nostocales	1117|Cyanobacteria	Q	PFAM Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_68069_38	344747.PM8797T_00177	3.615e-36	150.0	2ESRG@1|root,33K9V@2|Bacteria,2J33K@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_68069_8	378806.STAUR_0304	3.258e-176	592.0	COG0457@1|root,COG0515@1|root,COG3063@1|root,COG4695@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3063@2|Bacteria,COG4695@2|Bacteria,1MVEU@1224|Proteobacteria,4398J@68525|delta/epsilon subdivisions,2X4FU@28221|Deltaproteobacteria,2YYXQ@29|Myxococcales	28221|Deltaproteobacteria	T	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_68069_30	457570.Nther_1160	2.952e-58	217.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,25E6I@186801|Clostridia	186801|Clostridia	E	PFAM Cys Met metabolism	megL	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
CMS2_k127_68069_12	1121129.KB903371_gene192	6.515e-148	477.0	COG2262@1|root,COG2262@2|Bacteria,4NF0P@976|Bacteroidetes,2FM9T@200643|Bacteroidia,22W7M@171551|Porphyromonadaceae	976|Bacteroidetes	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
CMS2_k127_68069_32	316067.Geob_0905	1.652e-50	191.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,42MYJ@68525|delta/epsilon subdivisions,2WNGE@28221|Deltaproteobacteria,43UHS@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
CMS2_k127_68069_0	1047013.AQSP01000109_gene2437	6.422e-309	966.0	COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
CMS2_k127_68069_48	289376.THEYE_A1927	1.109e-12	73.0	COG0071@1|root,COG0071@2|Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	hspX	GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016310,GO:0019538,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0036294,GO:0040007,GO:0040008,GO:0042221,GO:0042594,GO:0043170,GO:0043207,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045926,GO:0046777,GO:0048519,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0071496,GO:0071704,GO:0071944,GO:0075136,GO:1901564	-	ko:K06335,ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS2_k127_68069_33	204669.Acid345_4041	2.748e-47	174.0	COG1327@1|root,COG1327@2|Bacteria,3Y4GA@57723|Acidobacteria,2JJC7@204432|Acidobacteriia	204432|Acidobacteriia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
CMS2_k127_68069_40	1047013.AQSP01000109_gene2439	4.001e-33	141.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS2_k127_68069_45	1263831.F543_9770	2.269e-20	95.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1Y8GW@135625|Pasteurellales	135625|Pasteurellales	K	Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
CMS2_k127_68069_27	207559.Dde_1717	8.238e-66	233.0	COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,42QCX@68525|delta/epsilon subdivisions,2WKYY@28221|Deltaproteobacteria,2M7Z3@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
CMS2_k127_68069_34	526222.Desal_3352	2.698e-45	172.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,42Q7D@68525|delta/epsilon subdivisions,2WKIT@28221|Deltaproteobacteria,2M8VZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	PFAM OmpA MotB domain protein	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
CMS2_k127_68069_37	1047013.AQSP01000139_gene2401	1.661e-37	156.0	COG0457@1|root,COG0457@2|Bacteria	1047013.AQSP01000139_gene2401|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_68069_49	649639.Bcell_0258	1.11e-12	76.0	COG1595@1|root,COG1595@2|Bacteria,1VDSM@1239|Firmicutes,4HN8P@91061|Bacilli,1ZCXA@1386|Bacillus	91061|Bacilli	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_68069_36	1267535.KB906767_gene3063	9.663e-40	157.0	COG0681@1|root,COG0681@2|Bacteria,3Y40D@57723|Acidobacteria,2JHWM@204432|Acidobacteriia	204432|Acidobacteriia	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
CMS2_k127_68069_19	484770.UFO1_0060	5.549e-110	369.0	COG3434@1|root,COG3434@2|Bacteria,1TPWC@1239|Firmicutes,4H2CH@909932|Negativicutes	909932|Negativicutes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,HDOD
CMS2_k127_68069_52	1537917.JU82_00340	3.84e-09	65.0	2DF2C@1|root,2ZQ7G@2|Bacteria,1RF8U@1224|Proteobacteria	1224|Proteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
CMS2_k127_68069_2	1168289.AJKI01000011_gene553	1.073e-254	803.0	COG1164@1|root,COG1164@2|Bacteria,4NFV3@976|Bacteroidetes,2FMG8@200643|Bacteroidia,3XKPK@558415|Marinilabiliaceae	976|Bacteroidetes	E	Oligoendopeptidase f	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_68069_22	331678.Cphamn1_1224	1.478e-93	325.0	COG0471@1|root,COG0471@2|Bacteria	2|Bacteria	P	metal ion transport	sdcS	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	CitMHS,Na_sulph_symp
CMS2_k127_68069_35	1114856.C496_04038	2.032e-40	159.0	COG0508@1|root,arCOG01706@2157|Archaea,2XUGY@28890|Euryarchaeota,23V33@183963|Halobacteria	183963|Halobacteria	C	COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
CMS2_k127_68069_51	1144275.COCOR_02883	3.287e-11	77.0	COG3509@1|root,COG3509@2|Bacteria,1MXUI@1224|Proteobacteria,430Q8@68525|delta/epsilon subdivisions,2WVYQ@28221|Deltaproteobacteria,2YU06@29|Myxococcales	28221|Deltaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
CMS2_k127_68069_44	497964.CfE428DRAFT_5098	3.216e-21	109.0	COG1075@1|root,COG1404@1|root,COG3055@1|root,COG3391@1|root,COG1075@2|Bacteria,COG1404@2|Bacteria,COG3055@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	1.1.3.6,3.2.1.4	ko:K01179,ko:K03333,ko:K12287	ko00500,ko00984,ko01100,ko01120,map00500,map00984,map01100,map01120	-	R01459,R06200,R11307,R11308	RC00146	ko00000,ko00001,ko01000,ko02044	-	GH5,GH9	-	Kelch_1,Laminin_G_3,Malectin
CMS2_k127_6820299_0	1117108.PAALTS15_22598	0.0	2287.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_6820299_7	398512.JQKC01000015_gene4634	7.419e-143	463.0	COG0826@1|root,COG0826@2|Bacteria,1VT69@1239|Firmicutes,25DBH@186801|Clostridia	186801|Clostridia	O	Peptidase family U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
CMS2_k127_6820299_6	573061.Clocel_2280	2.08e-144	477.0	COG1032@1|root,COG1032@2|Bacteria,1VFTA@1239|Firmicutes,24THB@186801|Clostridia,36T3W@31979|Clostridiaceae	186801|Clostridia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_6820299_3	1196323.ALKF01000205_gene4114	0.0	1273.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6820299_1	1009370.ALO_00935	0.0	1906.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_6820299_8	755731.Clo1100_0886	1.412e-92	314.0	COG0331@1|root,COG0331@2|Bacteria,1TRDU@1239|Firmicutes,24DDF@186801|Clostridia	186801|Clostridia	I	PFAM Acyl transferase	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
CMS2_k127_6820299_4	509191.AEDB02000067_gene921	1.158e-289	935.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6820299_5	394503.Ccel_2381	8.933e-238	772.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_31,PP-binding,ketoacyl-synt
CMS2_k127_6820299_10	246197.MXAN_3633	1.152e-59	225.0	COG2308@1|root,COG2308@2|Bacteria,1NKKV@1224|Proteobacteria	1224|Proteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6820299_9	246197.MXAN_3633	1.958e-60	237.0	COG2308@1|root,COG2308@2|Bacteria,1NKKV@1224|Proteobacteria	1224|Proteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6820299_11	591158.SSMG_05152	2.303e-18	101.0	COG2308@1|root,COG2308@2|Bacteria,2GP4E@201174|Actinobacteria	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6820299_2	1117108.PAALTS15_12777	0.0	1723.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K16124	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_6824638_0	755731.Clo1100_1305	1.269e-186	607.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36QT1@31979|Clostridiaceae	186801|Clostridia	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_31,NAD_binding_4,PP-binding,ketoacyl-synt
CMS2_k127_6826419_23	1244869.H261_13728	1.682e-81	292.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2JUYE@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
CMS2_k127_6826419_20	521011.Mpal_1518	2.364e-98	344.0	COG0784@1|root,arCOG02329@1|root,arCOG02329@2157|Archaea,arCOG02386@2157|Archaea,arCOG02391@2157|Archaea,2XVQ7@28890|Euryarchaeota	2157|Archaea	T	ATP-binding region, ATPase domain protein	-	-	-	ko:K03413,ko:K07662,ko:K07667	ko01503,ko02020,ko02024,ko02030,map01503,map02020,map02024,map02030	M00447,M00454,M00506,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	BAT,GAF_2,HATPase_c,HTH_10,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
CMS2_k127_6826419_6	521011.Mpal_1518	2.437e-141	477.0	COG0784@1|root,arCOG02329@1|root,arCOG02329@2157|Archaea,arCOG02386@2157|Archaea,arCOG02391@2157|Archaea,2XVQ7@28890|Euryarchaeota	2157|Archaea	T	ATP-binding region, ATPase domain protein	-	-	-	ko:K03413,ko:K07662,ko:K07667	ko01503,ko02020,ko02024,ko02030,map01503,map02020,map02024,map02030	M00447,M00454,M00506,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	BAT,GAF_2,HATPase_c,HTH_10,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
CMS2_k127_6826419_15	1167006.UWK_00567	1.775e-109	369.0	COG3005@1|root,COG3005@2|Bacteria,1R8V7@1224|Proteobacteria,42YES@68525|delta/epsilon subdivisions,2WU80@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM cytochrome C family protein	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS2_k127_6826419_2	880073.Calab_1263	2.281e-156	511.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS2_k127_6826419_41	880073.Calab_1262	2.62e-41	167.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_11
CMS2_k127_6826419_62	880073.Calab_1270	1.018e-12	81.0	2ENA5@1|root,33FXV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6826419_46	443144.GM21_3161	5.922e-30	129.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS2_k127_6826419_25	338969.Rfer_0256	7.309e-78	273.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,2VNUX@28216|Betaproteobacteria	28216|Betaproteobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
CMS2_k127_6826419_30	1167006.UWK_00561	2.571e-67	234.0	COG3303@1|root,COG3303@2|Bacteria,1NX4E@1224|Proteobacteria,431QJ@68525|delta/epsilon subdivisions,2WWSE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS2_k127_6826419_34	1232410.KI421416_gene2655	4.609e-57	208.0	28PU4@1|root,2ZCF6@2|Bacteria,1RBK2@1224|Proteobacteria,43B3E@68525|delta/epsilon subdivisions,2X6H4@28221|Deltaproteobacteria,43U05@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6826419_40	207559.Dde_1288	2.205e-43	166.0	COG0457@1|root,COG0457@2|Bacteria,1N0Q1@1224|Proteobacteria,42TBT@68525|delta/epsilon subdivisions,2WQ96@28221|Deltaproteobacteria,2MCPE@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	SMART Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
CMS2_k127_6826419_45	1123376.AUIU01000019_gene1267	2.84e-32	144.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
CMS2_k127_6826419_55	608538.HTH_1030	2.547e-20	103.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	flgR	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_6826419_57	1238450.VIBNISOn1_290024	5.1e-18	96.0	COG2197@1|root,COG2197@2|Bacteria,1MXI3@1224|Proteobacteria,1SRVN@1236|Gammaproteobacteria,1Y2F3@135623|Vibrionales	135623|Vibrionales	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K20918	ko05111,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	GerE
CMS2_k127_6826419_68	443144.GM21_3114	1.187e-07	61.0	COG3005@1|root,COG3005@2|Bacteria,1R8V7@1224|Proteobacteria,42YES@68525|delta/epsilon subdivisions,2WU80@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM cytochrome C family protein	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS2_k127_6826419_0	795359.TOPB45_0109	1.149e-241	767.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GHH0@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS2_k127_6826419_1	635013.TherJR_2857	1.505e-166	537.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia,264YF@186807|Peptococcaceae	186801|Clostridia	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
CMS2_k127_6826419_35	316067.Geob_0056	3.349e-56	207.0	COG0755@1|root,COG0755@2|Bacteria,1RG0A@1224|Proteobacteria,42N37@68525|delta/epsilon subdivisions,2WIKV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
CMS2_k127_6826419_69	498761.HM1_1961	1.693e-05	57.0	COG1333@1|root,COG1333@2|Bacteria,1TQ6C@1239|Firmicutes,24HES@186801|Clostridia	186801|Clostridia	O	ResB protein required for cytochrome c	resB	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
CMS2_k127_6826419_71	1515746.HR45_06145	0.0003645	53.0	COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RZUI@1236|Gammaproteobacteria,2QAN2@267890|Shewanellaceae	1236|Gammaproteobacteria	C	TIGRFAM cytochrome C family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1
CMS2_k127_6826419_56	1121920.AUAU01000024_gene2380	2.078e-18	96.0	COG3391@1|root,COG3391@2|Bacteria,3Y8A0@57723|Acidobacteria	57723|Acidobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
CMS2_k127_6826419_70	1515746.HR45_06145	6.177e-05	53.0	COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RZUI@1236|Gammaproteobacteria,2QAN2@267890|Shewanellaceae	1236|Gammaproteobacteria	C	TIGRFAM cytochrome C family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1
CMS2_k127_6826419_59	1121920.AUAU01000024_gene2380	2.098e-15	87.0	COG3391@1|root,COG3391@2|Bacteria,3Y8A0@57723|Acidobacteria	57723|Acidobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
CMS2_k127_6826419_38	595494.Tola_2121	1.492e-48	183.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1Y6P9@135624|Aeromonadales	135624|Aeromonadales	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
CMS2_k127_6826419_31	357244.OTBS_0295	3.416e-63	227.0	COG5464@1|root,COG5464@2|Bacteria,1R8FS@1224|Proteobacteria,2UMP3@28211|Alphaproteobacteria,47FF8@766|Rickettsiales	766|Rickettsiales	S	to TIGR01784	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
CMS2_k127_6826419_43	393921.HQ45_08550	2.483e-40	152.0	COG0251@1|root,COG0251@2|Bacteria,4NQ8M@976|Bacteroidetes,2FT8J@200643|Bacteroidia,22YB1@171551|Porphyromonadaceae	976|Bacteroidetes	J	Has endoribonuclease activity on mRNA	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
CMS2_k127_6826419_14	1379698.RBG1_1C00001G0378	2.235e-110	366.0	COG0150@1|root,COG0150@2|Bacteria,2NNUJ@2323|unclassified Bacteria	2|Bacteria	F	AIR synthase related protein, N-terminal domain	purM	GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.1,6.3.4.13	ko:K01933,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1844,iECSF_1327.ECSF_2340	AIRS,AIRS_C
CMS2_k127_6826419_64	123899.JPQP01000003_gene1260	3.504e-11	70.0	COG2207@1|root,COG3449@1|root,COG2207@2|Bacteria,COG3449@2|Bacteria,1MWTF@1224|Proteobacteria,2VQU7@28216|Betaproteobacteria,3T5Z3@506|Alcaligenaceae	28216|Betaproteobacteria	K	COG2207 AraC-type DNA-binding domain-containing proteins	tetD	-	-	ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18
CMS2_k127_6826419_61	1047013.AQSP01000133_gene2159	1.119e-13	76.0	COG1664@1|root,COG1664@2|Bacteria,2NQ1N@2323|unclassified Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin,zf-HC2
CMS2_k127_6826419_50	421072.IO89_05105	1.366e-24	121.0	COG2207@1|root,COG2207@2|Bacteria,4NG1D@976|Bacteroidetes,1HY6X@117743|Flavobacteriia,3HHDQ@358033|Chryseobacterium	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS2_k127_6826419_12	378806.STAUR_7504	4.522e-119	417.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,1QUYA@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
CMS2_k127_6826419_13	1047013.AQSP01000138_gene1058	4.894e-119	392.0	COG0182@1|root,COG0182@2|Bacteria,2NNM7@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0072	IF-2B
CMS2_k127_6826419_63	749222.Nitsa_1553	2.569e-11	76.0	COG2885@1|root,COG2885@2|Bacteria,1R8DG@1224|Proteobacteria,42NGC@68525|delta/epsilon subdivisions,2YN3X@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Belongs to the ompA family	cadF	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA
CMS2_k127_6826419_67	215803.DB30_1036	9.572e-09	68.0	COG0457@1|root,COG0484@1|root,COG0457@2|Bacteria,COG0484@2|Bacteria,1R6WM@1224|Proteobacteria,43AGT@68525|delta/epsilon subdivisions,2X5WS@28221|Deltaproteobacteria,2YVSQ@29|Myxococcales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,TPR_16
CMS2_k127_6826419_28	381764.Fnod_0595	4.641e-74	263.0	COG0665@1|root,COG0665@2|Bacteria,2GC7R@200918|Thermotogae	200918|Thermotogae	E	PFAM FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
CMS2_k127_6826419_51	247490.KSU1_D0863	7.608e-24	112.0	COG0526@1|root,COG0526@2|Bacteria,2J12A@203682|Planctomycetes	203682|Planctomycetes	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Thioredoxin_8
CMS2_k127_6826419_17	1167006.UWK_03542	3.765e-104	376.0	COG2204@1|root,COG5000@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,43DDR@68525|delta/epsilon subdivisions,2X8JR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,Response_reg
CMS2_k127_6826419_4	1125863.JAFN01000001_gene775	1.28e-148	482.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
CMS2_k127_6826419_8	237368.SCABRO_00285	2.707e-122	401.0	COG0110@1|root,COG0673@1|root,COG0110@2|Bacteria,COG0673@2|Bacteria,2IZ7A@203682|Planctomycetes	203682|Planctomycetes	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,Hexapep
CMS2_k127_6826419_7	459349.CLOAM0691	5.408e-140	451.0	COG0451@1|root,COG0451@2|Bacteria,2NNNX@2323|unclassified Bacteria	2|Bacteria	GM	NAD(P)H-binding	wbpP	-	5.1.3.2,5.1.3.7	ko:K01784,ko:K02473	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R00418,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS2_k127_6826419_36	1430440.MGMSRv2_4177	1.235e-52	190.0	COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,2U7G8@28211|Alphaproteobacteria,2JSAE@204441|Rhodospirillales	204441|Rhodospirillales	G	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
CMS2_k127_6826419_19	479434.Sthe_2756	5.738e-100	339.0	COG0399@1|root,COG0399@2|Bacteria,2G7XI@200795|Chloroflexi	200795|Chloroflexi	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_6826419_32	639030.JHVA01000001_gene3762	8.135e-61	221.0	COG0451@1|root,COG0451@2|Bacteria,3Y3ZG@57723|Acidobacteria,2JHT7@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS2_k127_6826419_37	273075.Ta0344m	3.437e-49	189.0	COG2605@1|root,arCOG01030@2157|Archaea,2Y7BC@28890|Euryarchaeota,242B5@183967|Thermoplasmata	183967|Thermoplasmata	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
CMS2_k127_6826419_29	1121939.L861_13660	2.017e-70	255.0	COG1520@1|root,COG1520@2|Bacteria,1NYGT@1224|Proteobacteria,1T1IK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotran_2,Arylsulfotrans
CMS2_k127_6826419_66	1206741.BAFX01000003_gene5434	9.884e-11	70.0	COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria,4FWV3@85025|Nocardiaceae	201174|Actinobacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rmlA	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005996,GO:0006006,GO:0006139,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009117,GO:0009141,GO:0009147,GO:0009200,GO:0009211,GO:0009219,GO:0009225,GO:0009226,GO:0009262,GO:0009394,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019299,GO:0019300,GO:0019305,GO:0019318,GO:0019319,GO:0019438,GO:0019637,GO:0019692,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0045226,GO:0046075,GO:0046364,GO:0046379,GO:0046383,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0334	NTP_transferase
CMS2_k127_6826419_53	391009.Tmel_1831	1.347e-21	101.0	COG1670@1|root,COG1670@2|Bacteria,2GCW5@200918|Thermotogae	200918|Thermotogae	J	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
CMS2_k127_6826419_39	1131269.AQVV01000005_gene375	1.313e-47	179.0	COG0224@1|root,COG0224@2|Bacteria	2|Bacteria	C	proton-transporting ATP synthase activity, rotational mechanism	-	-	-	-	-	-	-	-	-	-	-	-	WbqC
CMS2_k127_6826419_48	1124780.ANNU01000036_gene69	1.348e-28	132.0	2C5H2@1|root,2ZX8Q@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6826419_47	1121459.AQXE01000009_gene462	9.302e-29	128.0	COG4641@1|root,COG4641@2|Bacteria,1R64N@1224|Proteobacteria,42N73@68525|delta/epsilon subdivisions,2WM84@28221|Deltaproteobacteria,2M7XA@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	DUF based on E. rectale Gene description (DUF3880)	-	-	-	ko:K06320	-	-	-	-	ko00000	-	-	-	DUF3880,Glyco_trans_1_2
CMS2_k127_6826419_10	1124780.ANNU01000021_gene2983	4.971e-121	405.0	COG2244@1|root,COG2244@2|Bacteria,4PBQX@976|Bacteroidetes,47W6P@768503|Cytophagia	976|Bacteroidetes	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6826419_3	1499967.BAYZ01000085_gene5186	3.024e-156	498.0	COG0451@1|root,COG0451@2|Bacteria,2NNNX@2323|unclassified Bacteria	2|Bacteria	GM	NAD(P)H-binding	wbmF	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
CMS2_k127_6826419_5	1499967.BAYZ01000085_gene5187	2.258e-148	474.0	COG0463@1|root,COG0463@2|Bacteria,2NS3Y@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
CMS2_k127_6826419_52	1416760.AYMS01000057_gene3101	8.698e-24	107.0	COG0110@1|root,COG0110@2|Bacteria,4NH27@976|Bacteroidetes,1IIUF@117743|Flavobacteriia	976|Bacteroidetes	S	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2,Mac
CMS2_k127_6826419_60	368407.Memar_0199	2.295e-14	84.0	COG0392@1|root,arCOG00901@2157|Archaea,2Y3XP@28890|Euryarchaeota,2NB1Q@224756|Methanomicrobia	224756|Methanomicrobia	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS2_k127_6826419_58	1487923.DP73_03115	5.233e-16	91.0	COG1807@1|root,COG1807@2|Bacteria,1V0V2@1239|Firmicutes,24BJF@186801|Clostridia,263AS@186807|Peptococcaceae	186801|Clostridia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS2_k127_6826419_33	1089553.Tph_c25510	5.842e-59	221.0	COG1541@1|root,COG1541@2|Bacteria,1V5FH@1239|Firmicutes,24DHW@186801|Clostridia,42H23@68295|Thermoanaerobacterales	186801|Clostridia	H	coenzyme F390 synthetase	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
CMS2_k127_6826419_54	1121403.AUCV01000047_gene1041	1.72e-21	106.0	COG1215@1|root,COG1215@2|Bacteria,1QUG1@1224|Proteobacteria	1224|Proteobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_2_3,Glycos_transf_2
CMS2_k127_6826419_27	869213.JCM21142_41920	2.672e-75	267.0	COG2843@1|root,COG2843@2|Bacteria,4NRD6@976|Bacteroidetes,47XQQ@768503|Cytophagia	976|Bacteroidetes	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	-	-	-	-	-	-	-	-	-	PGA_cap
CMS2_k127_6826419_26	459349.CLOAM0665	6.969e-77	270.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_3,ATPgrasp_TupA,RimK
CMS2_k127_6826419_42	143224.JQMD01000002_gene3414	3.773e-41	167.0	COG0438@1|root,COG0438@2|Bacteria,4NPX0@976|Bacteroidetes	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_6826419_21	880073.Calab_0559	6.243e-89	316.0	COG0367@1|root,COG0367@2|Bacteria	2|Bacteria	E	asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7,TylF
CMS2_k127_6826419_22	880073.Calab_0558	1.116e-84	292.0	COG0151@1|root,COG0151@2|Bacteria,2NQIE@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the GarS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
CMS2_k127_6826419_18	1121007.AUML01000002_gene1664	7.792e-102	340.0	COG0438@1|root,COG0438@2|Bacteria,4NMHX@976|Bacteroidetes,1I6HQ@117743|Flavobacteriia,2YGV4@290174|Aquimarina	976|Bacteroidetes	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1
CMS2_k127_6826419_24	1296415.JACC01000044_gene2752	2.863e-80	274.0	COG0726@1|root,COG0726@2|Bacteria,4NM9J@976|Bacteroidetes,1IHIZ@117743|Flavobacteriia,2YH2S@290174|Aquimarina	976|Bacteroidetes	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6826419_16	880073.Calab_0556	5.299e-106	353.0	COG2348@1|root,COG2348@2|Bacteria	2|Bacteria	V	transferase activity, transferring amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6,FemAB
CMS2_k127_6826419_9	880073.Calab_0555	4.309e-121	398.0	COG1817@1|root,COG1817@2|Bacteria,2NQAK@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
CMS2_k127_6826419_11	880073.Calab_0548	3.64e-120	410.0	COG2148@1|root,COG2148@2|Bacteria,2NPSP@2323|unclassified Bacteria	2|Bacteria	M	Bacterial sugar transferase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_transf
CMS2_k127_6826419_44	1047013.AQSP01000112_gene391	1.193e-32	140.0	COG3307@1|root,COG3307@2|Bacteria,2NPHS@2323|unclassified Bacteria	2|Bacteria	M	O-Antigen ligase	tuaE	-	-	ko:K16705	-	-	-	-	ko00000	-	-	-	Wzy_C
CMS2_k127_6861933_0	118005.AWNK01000004_gene1064	1.744e-285	924.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6861933_1	1274524.BSONL12_07137	8.268e-273	872.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus	91061|Bacilli	Q	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall	-	-	-	ko:K16093	ko01054,map01054	-	-	-	ko00000,ko00001	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
CMS2_k127_6882636_0	398579.Spea_0261	6.267e-78	268.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,1RSCT@1236|Gammaproteobacteria,2QBA4@267890|Shewanellaceae	1236|Gammaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	ydhV	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016614,GO:0030151,GO:0033719,GO:0043167,GO:0043169,GO:0043546,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0097159,GO:1901363	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS2_k127_6882636_1	479437.Elen_2088	2.333e-66	233.0	COG1142@1|root,COG1142@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	1.2.1.58	ko:K18356	ko00360,map00360	-	R02450	RC00004,RC02860	br01601,ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,Fer4_11,Fer4_4,Fer4_6,Fer4_9,TPP_enzyme_C
CMS2_k127_6882636_3	272559.BF9343_0044	0.0001625	53.0	COG3391@1|root,COG3391@2|Bacteria,4P2J2@976|Bacteroidetes,2FP5A@200643|Bacteroidia,4APY7@815|Bacteroidaceae	976|Bacteroidetes	S	6-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128
CMS2_k127_6882636_2	443143.GM18_1262	2.512e-51	189.0	COG4832@1|root,COG4832@2|Bacteria,1RBGY@1224|Proteobacteria,42VX0@68525|delta/epsilon subdivisions,2WRUN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
CMS2_k127_6891234_0	96561.Dole_2404	8.067e-155	500.0	COG2303@1|root,COG2303@2|Bacteria,1QC41@1224|Proteobacteria,43E7D@68525|delta/epsilon subdivisions,2WZX2@28221|Deltaproteobacteria,2MN26@213118|Desulfobacterales	28221|Deltaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
CMS2_k127_6895634_2	509191.AEDB02000067_gene918	1.661e-65	229.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_6895634_0	509191.AEDB02000067_gene916	3.885e-192	616.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_6895634_1	509191.AEDB02000067_gene917	2.233e-89	310.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WNP0@541000|Ruminococcaceae	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6907745_3	368408.Tpen_1035	3.099e-07	63.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2XSQD@28889|Crenarchaeota	28889|Crenarchaeota	S	SMART zinc finger, RanBP2-type	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,UPF0547,zinc_ribbon_2
CMS2_k127_6907745_1	548477.HMPREF0294_2368	1.403e-30	138.0	2EW6K@1|root,33PJI@2|Bacteria,2I90P@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6907745_0	1280950.HJO_06715	1.252e-31	126.0	COG2801@1|root,COG2801@2|Bacteria,1RG0C@1224|Proteobacteria,2U7S5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,HTH_32,rve,rve_3
CMS2_k127_6907745_4	400682.PAC_15716036	8.529e-05	48.0	COG0666@1|root,KOG0504@2759|Eukaryota,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3BS6S@33208|Metazoa	33208|Metazoa	M	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_4,Ank_5
CMS2_k127_6907745_2	104355.XP_007869285.1	1.408e-08	56.0	COG0449@1|root,KOG1268@2759|Eukaryota,38DW1@33154|Opisthokonta,3NUR2@4751|Fungi,3UYU2@5204|Basidiomycota,226PR@155619|Agaricomycetes,3H4H2@355688|Agaricomycetes incertae sedis	4751|Fungi	M	SIS domain	GFA1	GO:0000271,GO:0003674,GO:0003824,GO:0004360,GO:0005975,GO:0005976,GO:0006002,GO:0006022,GO:0006023,GO:0006030,GO:0006031,GO:0006037,GO:0006038,GO:0006040,GO:0006041,GO:0006042,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009272,GO:0009987,GO:0010383,GO:0016043,GO:0016051,GO:0016740,GO:0016769,GO:0017144,GO:0019538,GO:0019637,GO:0030447,GO:0030448,GO:0033692,GO:0034221,GO:0034637,GO:0034641,GO:0034645,GO:0035690,GO:0036211,GO:0040007,GO:0042221,GO:0042493,GO:0042546,GO:0043170,GO:0043412,GO:0043413,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044281,GO:0045229,GO:0046349,GO:0046483,GO:0050896,GO:0051278,GO:0051716,GO:0055086,GO:0070085,GO:0070548,GO:0070589,GO:0070592,GO:0070887,GO:0071554,GO:0071704,GO:0071840,GO:0071852,GO:0071966,GO:1901071,GO:1901073,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iMM904.YKL104C,iND750.YKL104C	GATase_6,SIS
CMS2_k127_6916144_1	573061.Clocel_2482	0.0	1882.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_6916144_2	1009370.ALO_00935	0.0	1587.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_6916144_5	886379.AEWI01000006_gene747	3.844e-11	76.0	COG1215@1|root,COG1215@2|Bacteria,4NMSY@976|Bacteroidetes,2FSAI@200643|Bacteroidia,3XJ44@558415|Marinilabiliaceae	976|Bacteroidetes	M	Pfam Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
CMS2_k127_6916144_4	394503.Ccel_0972	6.632e-99	337.0	COG1819@1|root,COG1819@2|Bacteria,1TSPC@1239|Firmicutes,24D1S@186801|Clostridia,36ES5@31979|Clostridiaceae	186801|Clostridia	CG	TIGRFAM glycosyltransferase, MGT family	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
CMS2_k127_6916144_0	755731.Clo1100_0890	0.0	1898.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6916144_3	985665.HPL003_22320	1.979e-129	428.0	COG0001@1|root,COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0001@2|Bacteria,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	pksM1	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Aminotran_3,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6917562_6	696281.Desru_3331	1.344e-38	152.0	COG1556@1|root,COG1556@2|Bacteria,1VATZ@1239|Firmicutes,24P3S@186801|Clostridia,262FK@186807|Peptococcaceae	186801|Clostridia	C	PFAM Uncharacterised ACR, YkgG family COG1556	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
CMS2_k127_6917562_7	1122137.AQXF01000001_gene2804	4.956e-34	144.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
CMS2_k127_6917562_1	439235.Dalk_5268	4.278e-172	563.0	COG3356@1|root,COG3356@2|Bacteria,1QW1Q@1224|Proteobacteria,43BRP@68525|delta/epsilon subdivisions,2X72J@28221|Deltaproteobacteria,2MMRW@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
CMS2_k127_6917562_0	1449126.JQKL01000034_gene1290	1.321e-204	658.0	COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria,1TREQ@1239|Firmicutes,24BXS@186801|Clostridia	186801|Clostridia	C	Iron-sulfur cluster-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,LUD_dom
CMS2_k127_6917562_4	565033.GACE_1287	9.047e-66	232.0	COG1024@1|root,arCOG00239@2157|Archaea,2Y2NP@28890|Euryarchaeota,246M0@183980|Archaeoglobi	183980|Archaeoglobi	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS2_k127_6917562_10	319225.Plut_1305	1.347e-06	53.0	COG0330@1|root,COG0330@2|Bacteria,1FE5T@1090|Chlorobi	1090|Chlorobi	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS2_k127_6917562_5	643648.Slip_0515	8.846e-42	172.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_6917562_3	1408473.JHXO01000008_gene2655	1.494e-131	425.0	COG0330@1|root,COG0330@2|Bacteria,4NH8V@976|Bacteroidetes,2FQPC@200643|Bacteroidia	976|Bacteroidetes	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS2_k127_6917562_2	439235.Dalk_0736	2.947e-166	535.0	COG2204@1|root,COG2204@2|Bacteria,1MVWX@1224|Proteobacteria,42MIB@68525|delta/epsilon subdivisions,2WJQK@28221|Deltaproteobacteria,2MHU2@213118|Desulfobacterales	28221|Deltaproteobacteria	T	sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_6917562_8	644282.Deba_0484	8.022e-12	70.0	2ESCT@1|root,33JXK@2|Bacteria,1NK92@1224|Proteobacteria,42Y2H@68525|delta/epsilon subdivisions,2WSPA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6917562_9	1232410.KI421421_gene3333	4.224e-10	61.0	COG3237@1|root,COG3237@2|Bacteria,1NGW6@1224|Proteobacteria,42XTD@68525|delta/epsilon subdivisions,2WT90@28221|Deltaproteobacteria,43VVU@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	CsbD-like	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
CMS2_k127_6934819_0	795359.TOPB45_1400	6.16e-45	184.0	COG0021@1|root,COG0021@2|Bacteria,2GHJ7@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	Belongs to the transketolase family	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
CMS2_k127_6945539_0	509191.AEDB02000067_gene921	0.0	1518.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_6946396_0	1449342.JQMR01000001_gene1129	1.926e-13	84.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,4HDSE@91061|Bacilli	91061|Bacilli	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS2_k127_6946396_1	1235813.JCM10003_1433	2.566e-10	74.0	COG0358@1|root,COG0358@2|Bacteria,4NH5X@976|Bacteroidetes,2FPHT@200643|Bacteroidia,4AKC7@815|Bacteroidaceae	976|Bacteroidetes	L	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_2,zf-CHC2
CMS2_k127_6977262_0	1449357.JQLK01000001_gene1210	1.798e-39	170.0	COG1520@1|root,COG4447@1|root,COG1520@2|Bacteria,COG4447@2|Bacteria,1WJIB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6977262_4	1356852.N008_08500	0.000949	53.0	COG1404@1|root,COG1404@2|Bacteria,4NFMW@976|Bacteroidetes,47X9G@768503|Cytophagia	976|Bacteroidetes	O	PFAM peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	MAM,PKD,Peptidase_S8
CMS2_k127_6977262_1	1340493.JNIF01000003_gene2074	3.542e-20	107.0	COG3209@1|root,COG3209@2|Bacteria,3Y5Q3@57723|Acidobacteria	2|Bacteria	M	COG3209 Rhs family protein	tccC1	-	-	ko:K11021	-	-	-	-	ko00000,ko02042	-	-	-	-
CMS2_k127_6977262_3	933262.AXAM01000013_gene1303	7.438e-09	57.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
CMS2_k127_6977262_2	593750.Metfor_1783	1.517e-15	79.0	COG1598@1|root,arCOG02412@2157|Archaea	2157|Archaea	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6987167_1	671143.DAMO_3115	5.68e-101	346.0	COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria	2|Bacteria	O	smart pdz dhr glgf	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
CMS2_k127_6987167_3	1047013.AQSP01000109_gene2435	3.496e-30	130.0	COG0253@1|root,COG0253@2|Bacteria,2NPFA@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0566,iLJ478.TM1522	DAP_epimerase
CMS2_k127_6987167_0	667014.Thein_0938	2.869e-163	531.0	COG0210@1|root,COG0210@2|Bacteria,2GGRZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF3553,UvrD-helicase,UvrD_C
CMS2_k127_7008751_7	1278073.MYSTI_04091	2.009e-48	195.0	2DV3U@1|root,33TXD@2|Bacteria,1NUW0@1224|Proteobacteria,439EF@68525|delta/epsilon subdivisions,2X4PK@28221|Deltaproteobacteria,2Z06V@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_7008751_15	1121373.KB903639_gene3769	4.234e-07	61.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HATPase_c,HisKA_3,PAS_9,Response_reg
CMS2_k127_7008751_17	1411685.U062_02363	3.188e-05	47.0	COG1373@1|root,COG1373@2|Bacteria,1R9U4@1224|Proteobacteria,1SMVA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
CMS2_k127_7008751_10	1499967.BAYZ01000184_gene4604	2.884e-31	134.0	29AZW@1|root,2ZXYU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_7008751_9	667014.Thein_1499	3.819e-42	159.0	COG2405@1|root,COG2405@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3368
CMS2_k127_7008751_11	28072.Nos7524_1232	4.899e-28	114.0	COG2886@1|root,COG2886@2|Bacteria,1G7YG@1117|Cyanobacteria,1HU6N@1161|Nostocales	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0175	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
CMS2_k127_7008751_0	1047013.AQSP01000140_gene2510	4.133e-204	649.0	COG4690@1|root,COG4690@2|Bacteria,2NQ92@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family C69	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
CMS2_k127_7008751_5	504472.Slin_3688	1.314e-103	357.0	COG1680@1|root,COG1680@2|Bacteria,4NEEP@976|Bacteroidetes,47KW2@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_7008751_2	880073.Calab_0992	5.87e-114	374.0	COG2006@1|root,COG2006@2|Bacteria,2NQF7@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS2_k127_7008751_6	768710.DesyoDRAFT_2029	1.962e-92	315.0	COG1146@1|root,COG1146@2|Bacteria,1UZSY@1239|Firmicutes,25EKY@186801|Clostridia,263BD@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
CMS2_k127_7008751_4	439235.Dalk_0237	8.185e-106	378.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036	-	-	-	Glucosaminidase,Rod-binding
CMS2_k127_7008751_14	215803.DB30_3970	4.319e-15	90.0	COG3266@1|root,COG3568@1|root,COG3266@2|Bacteria,COG3568@2|Bacteria,1N2ZJ@1224|Proteobacteria,42WUR@68525|delta/epsilon subdivisions,2WSUA@28221|Deltaproteobacteria,2YUA6@29|Myxococcales	28221|Deltaproteobacteria	PQ	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,LTD
CMS2_k127_7008751_3	1499967.BAYZ01000147_gene711	1.783e-109	389.0	28K2M@1|root,2Z9RY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_7008751_1	102125.Xen7305DRAFT_00014920	2.756e-128	420.0	2DBYN@1|root,2ZBWH@2|Bacteria,1GBJR@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_7008751_8	1047013.AQSP01000106_gene1773	7.859e-48	194.0	COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4976,Sulfatase
CMS2_k127_7008751_12	290512.Paes_2210	8.259e-22	104.0	2EDYH@1|root,337TB@2|Bacteria,1FEFX@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_7008751_13	324925.Ppha_2425	9.562e-21	102.0	2E9II@1|root,333RI@2|Bacteria,1FEZP@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_7033318_8	1265505.ATUG01000002_gene1817	6.695e-20	91.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42NWQ@68525|delta/epsilon subdivisions,2WM5R@28221|Deltaproteobacteria,2MJ8Y@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,PAS,PAS_4
CMS2_k127_7033318_1	118163.Ple7327_1082	4.686e-160	522.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	1.17.99.1	ko:K05797	ko00623,ko01100,ko01120,map00623,map01100,map01120	-	R02675,R11194	RC00769	ko00000,ko00001,ko01000	-	-	-	FAD_binding_4
CMS2_k127_7033318_5	1120953.AUBH01000001_gene763	1.769e-80	278.0	COG0664@1|root,COG0664@2|Bacteria,1RKRH@1224|Proteobacteria,1S42Z@1236|Gammaproteobacteria,46BUZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
CMS2_k127_7033318_2	1304885.AUEY01000002_gene436	1.277e-136	451.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QB7@68525|delta/epsilon subdivisions,2WM6Y@28221|Deltaproteobacteria,2MHYS@213118|Desulfobacterales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
CMS2_k127_7033318_3	1499967.BAYZ01000137_gene105	6.13e-125	422.0	COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,2NPJ3@2323|unclassified Bacteria	2|Bacteria	T	diguanylate cyclase	pleD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
CMS2_k127_7033318_7	1112274.KI911560_gene2425	3.99e-30	138.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2VVWD@28216|Betaproteobacteria,2KPBH@206350|Nitrosomonadales	206350|Nitrosomonadales	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_7033318_4	1304885.AUEY01000002_gene433	1.227e-107	368.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MHUJ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Periplasmic sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,HAMP,HATPase_c,HisKA,Hpt,PAS_3,Response_reg
CMS2_k127_7033318_6	269799.Gmet_1668	7.289e-41	157.0	2E3CB@1|root,32YBM@2|Bacteria,1N6WD@1224|Proteobacteria,42UIS@68525|delta/epsilon subdivisions,2WR4F@28221|Deltaproteobacteria,43VIR@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4154)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154
CMS2_k127_7033318_0	269799.Gmet_1669	4.176e-218	697.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42PWS@68525|delta/epsilon subdivisions,2WKI5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
CMS2_k127_70800_6	1535422.ND16A_2441	3.735e-148	496.0	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria,2Q7GY@267889|Colwelliaceae	1236|Gammaproteobacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_70800_2	358681.BBR47_39840	0.0	1421.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HUE5@91061|Bacilli,26VP1@186822|Paenibacillaceae	91061|Bacilli	Q	Pfam:HxxPF_rpt	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Condensation,Methyltransf_12,NAD_binding_4,PP-binding
CMS2_k127_70800_3	1469607.KK073768_gene3281	0.0	1345.0	COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1HJVE@1161|Nostocales	1117|Cyanobacteria	Q	COGs COG3321 Polyketide synthase modules and related protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_70800_1	536232.CLM_0373	0.0	1720.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_70800_0	1042163.BRLA_c025650	0.0	4654.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K15662	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_70800_4	118005.AWNK01000004_gene1064	3.478e-284	942.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_70800_5	1007103.AFHW01000215_gene834	1.806e-153	505.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_72080_0	573061.Clocel_2486	1.681e-135	460.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_72080_1	1254432.SCE1572_19765	2.433e-112	378.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,42NGU@68525|delta/epsilon subdivisions,2WIM5@28221|Deltaproteobacteria,2YVCR@29|Myxococcales	28221|Deltaproteobacteria	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS2_k127_72080_2	592316.Pat9b_3248	1.643e-05	49.0	COG5464@1|root,COG5464@2|Bacteria,1MUSP@1224|Proteobacteria,1RNUW@1236|Gammaproteobacteria	1224|Proteobacteria	S	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_31
CMS2_k127_765124_0	1499967.BAYZ01000100_gene3454	4.068e-164	534.0	2EVWS@1|root,33PAF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_765124_1	45351.EDO34694	8.998e-11	67.0	2CMFF@1|root,2QQ7E@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
CMS2_k127_768796_1	1321775.HMPREF1980_01899	1.773e-12	67.0	COG4115@1|root,COG4115@2|Bacteria,2ISYH@201174|Actinobacteria,4D6AU@85005|Actinomycetales	201174|Actinobacteria	S	YoeB-like toxin of bacterial type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	YoeB_toxin
CMS2_k127_768796_2	397288.C806_00398	3.915e-07	55.0	COG2161@1|root,COG2161@2|Bacteria,1VI3T@1239|Firmicutes,24R01@186801|Clostridia,27Q9R@186928|unclassified Lachnospiraceae	186801|Clostridia	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
CMS2_k127_768796_0	933262.AXAM01000028_gene3343	6.837e-119	396.0	COG1373@1|root,COG1373@2|Bacteria,1MWDX@1224|Proteobacteria,4302U@68525|delta/epsilon subdivisions,2WVDX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_775206_0	439235.Dalk_2315	9.212e-23	115.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
CMS2_k127_77858_1	1237149.C900_03083	1.056e-25	109.0	COG1017@1|root,COG1017@2|Bacteria	2|Bacteria	C	nitric oxide dioxygenase activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	Globin
CMS2_k127_77858_2	301.JNHE01000011_gene3658	2.277e-18	91.0	COG1017@1|root,COG1017@2|Bacteria,1RI9P@1224|Proteobacteria,1S7H7@1236|Gammaproteobacteria,1YJ8U@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	nitric oxide dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_77858_0	1237149.C900_04032	7.133e-52	199.0	COG3447@1|root,COG4251@1|root,COG3447@2|Bacteria,COG4251@2|Bacteria,4NI5R@976|Bacteroidetes	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE1
CMS2_k127_778646_6	439235.Dalk_2974	1.761e-108	366.0	COG0642@1|root,COG2199@1|root,COG3437@1|root,COG0642@2|Bacteria,COG3437@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43BSG@68525|delta/epsilon subdivisions,2WK8V@28221|Deltaproteobacteria,2MHZC@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
CMS2_k127_778646_16	29540.C481_12424	2.268e-25	117.0	COG0697@1|root,arCOG00271@2157|Archaea,2XXKE@28890|Euryarchaeota,23S6P@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS2_k127_778646_21	666686.B1NLA3E_19710	3.916e-06	59.0	COG3391@1|root,COG3391@2|Bacteria,1V2KS@1239|Firmicutes,4IQ9M@91061|Bacilli,1ZD44@1386|Bacillus	91061|Bacilli	S	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,NHL
CMS2_k127_778646_12	234267.Acid_3395	1.817e-38	149.0	2FGUY@1|root,348Q9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_778646_17	760117.JN27_20910	1.28e-23	105.0	2DR9X@1|root,33AUW@2|Bacteria,1NKHC@1224|Proteobacteria,2WCWV@28216|Betaproteobacteria,478BV@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	PrcB C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_778646_0	926550.CLDAP_15630	1.919e-220	698.0	COG0442@1|root,COG0442@2|Bacteria,2G5Q6@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
CMS2_k127_778646_19	582515.KR51_00011080	1.118e-15	85.0	COG2813@1|root,COG2813@2|Bacteria	2|Bacteria	J	rRNA (guanine-N2-)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase,MMPL,Methyltransf_21,Methyltransf_25,Methyltransf_31
CMS2_k127_778646_15	1237149.C900_04045	2.697e-32	138.0	COG3595@1|root,COG3595@2|Bacteria,4NMHT@976|Bacteroidetes,47PEC@768503|Cytophagia	976|Bacteroidetes	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS2_k127_778646_9	1131269.AQVV01000007_gene1029	1.891e-46	178.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS2_k127_778646_14	626887.J057_13241	2.155e-36	140.0	COG2329@1|root,COG2329@2|Bacteria,1N2ZS@1224|Proteobacteria	1224|Proteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_778646_3	86416.Clopa_0768	3.107e-150	484.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,36F1U@31979|Clostridiaceae	186801|Clostridia	C	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
CMS2_k127_778646_2	1210884.HG799463_gene9356	8.91e-152	513.0	COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria,2J2QP@203682|Planctomycetes	203682|Planctomycetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Reg_prop,Y_Y_Y
CMS2_k127_778646_18	1121921.KB898706_gene2500	6.848e-18	99.0	COG4977@1|root,COG4977@2|Bacteria,1R01Y@1224|Proteobacteria,1T4DW@1236|Gammaproteobacteria,2PQM8@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS2_k127_778646_8	765911.Thivi_3711	9.849e-55	203.0	COG4870@1|root,COG4870@2|Bacteria,1RJ0M@1224|Proteobacteria,1SES2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
CMS2_k127_778646_1	1121904.ARBP01000006_gene3760	5.826e-158	526.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47MUE@768503|Cytophagia	976|Bacteroidetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_778646_22	1047013.AQSP01000132_gene1742	9.224e-05	54.0	COG3391@1|root,COG3391@2|Bacteria,2NQ4G@2323|unclassified Bacteria	2|Bacteria	O	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,NHL,TolB_like
CMS2_k127_778646_4	880073.Calab_2466	1.421e-130	424.0	COG0714@1|root,COG0714@2|Bacteria,2NNMQ@2323|unclassified Bacteria	2|Bacteria	S	ATPase associated with various cellular	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS2_k127_778646_10	1047013.AQSP01000077_gene2270	5.369e-44	169.0	COG1484@1|root,COG1484@2|Bacteria,2NQ23@2323|unclassified Bacteria	2|Bacteria	L	IstB-like ATP binding protein	dnaC	-	3.4.21.53	ko:K02315,ko:K04076	-	-	-	-	ko00000,ko01000,ko01002,ko03032	-	-	-	AAA,IstB_IS21,Lon_C
CMS2_k127_778646_11	891968.Anamo_0432	6.97e-42	166.0	COG0568@1|root,COG0568@2|Bacteria,3TACS@508458|Synergistetes	508458|Synergistetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS2_k127_778646_13	1047013.AQSP01000077_gene2268	1.782e-36	142.0	COG0789@1|root,COG0789@2|Bacteria,2NPTR@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulator, MerR family	hspR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
CMS2_k127_778646_5	1047013.AQSP01000077_gene2267	8.806e-110	366.0	COG0484@1|root,COG0484@2|Bacteria,2NNSJ@2323|unclassified Bacteria	2|Bacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
CMS2_k127_778646_7	1173026.Glo7428_2195	1.728e-90	306.0	COG2084@1|root,COG2084@2|Bacteria,1G34X@1117|Cyanobacteria	1117|Cyanobacteria	I	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid	mmsB	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
CMS2_k127_778646_20	1047013.AQSP01000068_gene2281	1.324e-07	64.0	28WP9@1|root,2ZINZ@2|Bacteria	1047013.AQSP01000068_gene2281|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_793142_6	1313421.JHBV01000041_gene3465	4.867e-15	91.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Calx-beta,DUF4183,SLH,VCBS
CMS2_k127_793142_4	439235.Dalk_4722	3.538e-52	213.0	COG4886@1|root,COG4886@2|Bacteria,1PEHG@1224|Proteobacteria,43AB5@68525|delta/epsilon subdivisions,2WX27@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Leucine Rich Repeat	-	-	-	-	-	-	-	-	-	-	-	-	LRR_8
CMS2_k127_793142_3	1191523.MROS_2005	6.664e-95	351.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_793142_7	331678.Cphamn1_2339	1.587e-07	55.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	vapC	-	2.3.1.30	ko:K00640,ko:K07062	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000,ko02048	-	-	-	PIN
CMS2_k127_793142_5	879212.DespoDRAFT_03734	1.136e-27	114.0	COG2161@1|root,COG2161@2|Bacteria,1NBSZ@1224|Proteobacteria,4332I@68525|delta/epsilon subdivisions,2WXB2@28221|Deltaproteobacteria,2MPCN@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
CMS2_k127_793142_0	580340.Tlie_0459	0.0	1076.0	COG1483@1|root,COG1483@2|Bacteria	2|Bacteria	C	ATPase (AAA superfamily	pglY	-	-	-	-	-	-	-	-	-	-	-	DUF499
CMS2_k127_793142_2	580340.Tlie_0460	4.649e-124	404.0	28HSY@1|root,2Z7ZY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_793142_1	580340.Tlie_0461	1.143e-221	698.0	COG1743@1|root,COG1743@2|Bacteria,3TCDM@508458|Synergistetes	508458|Synergistetes	L	DNA methylAse	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_8221_5	717231.Flexsi_0986	1.068e-15	83.0	COG1762@1|root,COG1762@2|Bacteria,2GFU6@200930|Deferribacteres	200930|Deferribacteres	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
CMS2_k127_8221_2	1307761.L21SP2_1995	2.396e-26	112.0	COG0347@1|root,COG0347@2|Bacteria,2J85W@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the P(II) protein family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_8221_3	933262.AXAM01000014_gene262	2.037e-21	108.0	COG0025@1|root,COG0025@2|Bacteria,1N7PG@1224|Proteobacteria,42V45@68525|delta/epsilon subdivisions,2WRJ6@28221|Deltaproteobacteria,2MN9H@213118|Desulfobacterales	28221|Deltaproteobacteria	P	NhaP-type Na H and K H	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_8221_1	880073.Calab_0958	3.27e-63	233.0	COG0475@1|root,COG0475@2|Bacteria	2|Bacteria	P	glutathione-regulated potassium exporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
CMS2_k127_8221_4	1233950.IW22_18615	4.736e-16	90.0	COG1331@1|root,COG1331@2|Bacteria,4NMU8@976|Bacteroidetes,1IK15@117743|Flavobacteriia,3ZUQ8@59732|Chryseobacterium	976|Bacteroidetes	O	Protein of unknown function, DUF255	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin,Thioredoxin_2,Thioredoxin_7
CMS2_k127_8221_0	1047013.AQSP01000061_gene1216	1.408e-104	364.0	COG3408@1|root,COG3408@2|Bacteria,2NPYR@2323|unclassified Bacteria	2|Bacteria	G	Amylo-alpha-1,6-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
CMS2_k127_85843_7	1122925.KB895377_gene1285	1.756e-06	53.0	COG4733@1|root,COG4833@1|root,COG4733@2|Bacteria,COG4833@2|Bacteria,1W08N@1239|Firmicutes,4IUT5@91061|Bacilli,26ZBI@186822|Paenibacillaceae	91061|Bacilli	G	Beta/Gamma crystallin	-	-	-	-	-	-	-	-	-	-	-	-	Crystall
CMS2_k127_85843_2	1123508.JH636446_gene6264	5.342e-199	651.0	COG0823@1|root,COG1262@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1262@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	dap2	-	2.7.11.1,3.4.19.1	ko:K01303,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko01002	-	-	-	DUF1566,FGE-sulfatase,PD40,Peptidase_S9
CMS2_k127_85843_4	56780.SYN_00402	9.054e-168	538.0	COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria,42NWP@68525|delta/epsilon subdivisions,2WJUA@28221|Deltaproteobacteria,2MQYG@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
CMS2_k127_85843_6	398512.JQKC01000015_gene4631	1.865e-83	320.0	COG1020@1|root,COG1020@2|Bacteria,1V12Q@1239|Firmicutes,24ER3@186801|Clostridia	186801|Clostridia	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Condensation,PP-binding
CMS2_k127_85843_0	1196323.ALKF01000205_gene4114	0.0	2102.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_85843_5	573061.Clocel_2628	5.756e-118	434.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36F06@31979|Clostridiaceae	186801|Clostridia	Q	Amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_85843_3	509191.AEDB02000067_gene916	1.692e-191	613.0	COG1032@1|root,COG1032@2|Bacteria,1VB1B@1239|Firmicutes,24U4G@186801|Clostridia	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_85843_1	118005.AWNK01000004_gene1064	1.068e-310	1006.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	6.2.1.46	ko:K15646,ko:K15667	ko01054,map01054	-	R11084	RC00039,RC00137	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_866429_29	96561.Dole_2466	2.9e-35	153.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PTPS_related,YfhO
CMS2_k127_866429_7	56780.SYN_02911	1.815e-117	391.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,42NJU@68525|delta/epsilon subdivisions,2X9WU@28221|Deltaproteobacteria,2MRQN@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_866429_22	865937.Gilli_0793	2.375e-52	206.0	COG1228@1|root,COG1228@2|Bacteria,4NEV0@976|Bacteroidetes,1IH9T@117743|Flavobacteriia,2P7KS@244698|Gillisia	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS2_k127_866429_43	406124.ACPC01000047_gene1767	6.244e-17	96.0	2EE19@1|root,337W3@2|Bacteria,1VR21@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_866429_2	406124.ACPC01000047_gene1770	4.078e-260	839.0	COG0497@1|root,COG0497@2|Bacteria,1UK2X@1239|Firmicutes	1239|Firmicutes	L	Tubulin like	-	-	-	-	-	-	-	-	-	-	-	-	Tubulin_2
CMS2_k127_866429_44	406124.ACPC01000047_gene1772	3.778e-14	86.0	COG2304@1|root,COG2304@2|Bacteria,1VM0M@1239|Firmicutes,4IBR2@91061|Bacilli,1ZHCS@1386|Bacillus	91061|Bacilli	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_866429_27	411154.GFO_3513	4.844e-40	162.0	2DBJ5@1|root,2Z9IG@2|Bacteria,4NI72@976|Bacteroidetes,1I06W@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_866429_19	515635.Dtur_1286	1.383e-67	248.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122
CMS2_k127_866429_34	933262.AXAM01000063_gene610	1.001e-30	121.0	COG1598@1|root,COG1598@2|Bacteria,1PKQ0@1224|Proteobacteria,438VX@68525|delta/epsilon subdivisions,2X9PU@28221|Deltaproteobacteria,2MPDH@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_866429_49	933262.AXAM01000063_gene611	0.0001746	44.0	COG1724@1|root,COG1724@2|Bacteria,1NP3B@1224|Proteobacteria	1224|Proteobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
CMS2_k127_866429_31	357808.RoseRS_3946	7.428e-34	146.0	COG1672@1|root,COG1672@2|Bacteria,2GA3V@200795|Chloroflexi,376JQ@32061|Chloroflexia	32061|Chloroflexia	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
CMS2_k127_866429_35	517418.Ctha_2056	1.39e-30	138.0	COG0265@1|root,COG0265@2|Bacteria,1FDIE@1090|Chlorobi	1090|Chlorobi	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS2_k127_866429_39	1047013.AQSP01000111_gene1679	3.655e-25	111.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	sigG	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_866429_30	215803.DB30_4432	2.467e-34	136.0	COG0764@1|root,COG0764@2|Bacteria	2|Bacteria	I	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	fabZ	-	3.5.1.108,4.2.1.59	ko:K02372,ko:K16363	ko00061,ko00540,ko00780,ko01100,ko01212,map00061,map00540,map00780,map01100,map01212	M00060,M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	-	-	-	FabA,LpxC
CMS2_k127_866429_24	246194.CHY_1445	3.261e-48	189.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,42FCV@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS2_k127_866429_10	309799.DICTH_0796	1.311e-109	368.0	COG0304@1|root,COG0304@2|Bacteria	2|Bacteria	I	3-oxoacyl-[acyl-carrier-protein] synthase activity	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS2_k127_866429_17	1408422.JHYF01000001_gene2943	1.466e-70	248.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,36EGR@31979|Clostridiaceae	186801|Clostridia	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS2_k127_866429_42	1118054.CAGW01000063_gene2193	3.934e-23	107.0	COG0778@1|root,COG0778@2|Bacteria,1V2D6@1239|Firmicutes,4HCP0@91061|Bacilli,26TVG@186822|Paenibacillaceae	91061|Bacilli	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS2_k127_866429_37	1268635.Loa_00422	3.08e-26	112.0	COG0236@1|root,COG0236@2|Bacteria,1NM9E@1224|Proteobacteria,1SINP@1236|Gammaproteobacteria,1JEJN@118969|Legionellales	118969|Legionellales	IQ	Phosphopantetheine attachment site	acpP_2	-	-	-	-	-	-	-	-	-	-	-	PP-binding
CMS2_k127_866429_18	215803.DB30_4430	4.605e-69	242.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2WJ64@28221|Deltaproteobacteria,2YV5Q@29|Myxococcales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.304,1.1.1.47,1.1.1.76	ko:K00034,ko:K03366	ko00030,ko00650,ko01120,ko01200,map00030,map00650,map01120,map01200	-	R01520,R01521,R02855,R02946,R03707,R09078,R10505	RC00066,RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
CMS2_k127_866429_13	215803.DB30_4429	1.139e-98	339.0	COG1964@1|root,COG1964@2|Bacteria,1QE02@1224|Proteobacteria,42M4B@68525|delta/epsilon subdivisions,2WJDI@28221|Deltaproteobacteria,2Z03B@29|Myxococcales	28221|Deltaproteobacteria	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
CMS2_k127_866429_12	215803.DB30_4431	1.152e-101	347.0	COG1964@1|root,COG1964@2|Bacteria,1QE02@1224|Proteobacteria,42M4B@68525|delta/epsilon subdivisions,2WJDI@28221|Deltaproteobacteria,2Z03B@29|Myxococcales	28221|Deltaproteobacteria	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
CMS2_k127_866429_46	1408444.JHYC01000017_gene1963	1.691e-12	73.0	COG0764@1|root,COG0764@2|Bacteria,1PCKD@1224|Proteobacteria,1SXNH@1236|Gammaproteobacteria,1JDAD@118969|Legionellales	118969|Legionellales	I	FabA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	FabA
CMS2_k127_866429_47	1399115.U719_01805	6.626e-12	78.0	COG0607@1|root,COG0607@2|Bacteria,1VB3C@1239|Firmicutes,4HKWP@91061|Bacilli	91061|Bacilli	P	rhodanese	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CMS2_k127_866429_20	1391647.AVSV01000022_gene2477	3.978e-63	244.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,36DBS@31979|Clostridiaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_866429_0	909663.KI867150_gene476	0.0	1124.0	COG0366@1|root,COG0366@2|Bacteria,1PDXT@1224|Proteobacteria,43789@68525|delta/epsilon subdivisions,2X2AW@28221|Deltaproteobacteria,2MS3Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
CMS2_k127_866429_28	1047013.AQSP01000132_gene1732	8.396e-38	147.0	COG1259@1|root,COG1259@2|Bacteria,2NP7X@2323|unclassified Bacteria	2|Bacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03617,ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,UVR
CMS2_k127_866429_16	868864.Dester_0800	1.015e-75	273.0	COG0260@1|root,COG0260@2|Bacteria,2G3TV@200783|Aquificae	200783|Aquificae	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
CMS2_k127_866429_21	1519464.HY22_03095	1.368e-53	206.0	COG0451@1|root,COG0451@2|Bacteria,1FDUB@1090|Chlorobi	1090|Chlorobi	M	3-beta hydroxysteroid dehydrogenase isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS2_k127_866429_36	1395587.P364_0128545	1.03e-28	126.0	COG0739@1|root,COG4870@1|root,COG0739@2|Bacteria,COG4870@2|Bacteria,1V236@1239|Firmicutes,4HK9V@91061|Bacilli,26ZBY@186822|Paenibacillaceae	91061|Bacilli	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
CMS2_k127_866429_1	1047013.AQSP01000144_gene927	1.441e-286	893.0	COG3533@1|root,COG3533@2|Bacteria,2NNW0@2323|unclassified Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	F5_F8_type_C,Glyco_hydro_127
CMS2_k127_866429_41	338966.Ppro_0557	1.568e-24	104.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM Cold-shock protein, DNA-binding	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CMS2_k127_866429_40	497964.CfE428DRAFT_3685	1.252e-24	110.0	COG0071@1|root,COG0071@2|Bacteria,46T3G@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Belongs to the small heat shock protein (HSP20) family	ibpA	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS2_k127_866429_9	1047013.AQSP01000109_gene2434	1.737e-112	379.0	COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria	2|Bacteria	O	smart pdz dhr glgf	htrA	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS2_k127_866429_15	247490.KSU1_B0463	5.985e-84	301.0	COG4232@1|root,COG4232@2|Bacteria,2IXJF@203682|Planctomycetes	203682|Planctomycetes	CO	Cytochrome c biogenesis protein transmembrane region	-	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_2,Thioredoxin_7
CMS2_k127_866429_50	373903.Hore_11910	0.0001986	54.0	COG0457@1|root,COG0457@2|Bacteria,1UYZH@1239|Firmicutes,25HWG@186801|Clostridia,3WBNK@53433|Halanaerobiales	186801|Clostridia	S	PFAM Tetratricopeptide TPR_1 repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
CMS2_k127_866429_3	1047013.AQSP01000137_gene570	2.255e-165	530.0	COG0422@1|root,COG0422@2|Bacteria,2NNV7@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2910	ThiC_Rad_SAM
CMS2_k127_866429_23	485913.Krac_12550	9.75e-52	193.0	COG1235@1|root,COG1235@2|Bacteria,2G833@200795|Chloroflexi	200795|Chloroflexi	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CMS2_k127_866429_14	1047013.AQSP01000043_gene53	2.101e-93	312.0	COG0217@1|root,COG0217@2|Bacteria,2NNSI@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
CMS2_k127_866429_38	2340.JV46_27620	1.107e-25	111.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1J63F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
CMS2_k127_866429_33	1191523.MROS_0743	1.343e-32	134.0	COG0632@1|root,COG0632@2|Bacteria	2|Bacteria	L	four-way junction helicase activity	ruvA	GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
CMS2_k127_866429_6	243231.GSU1077	7.256e-131	425.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2WJ2Q@28221|Deltaproteobacteria,43TWH@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
CMS2_k127_866429_26	1047013.AQSP01000128_gene413	5.087e-41	161.0	2DU2Y@1|root,33NQT@2|Bacteria	2|Bacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_4
CMS2_k127_866429_8	1047013.AQSP01000128_gene414	1.087e-112	372.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	nosF	-	-	ko:K01990,ko:K19340	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC_tran
CMS2_k127_866429_25	1047013.AQSP01000128_gene415	5.996e-43	168.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	nosY	-	-	ko:K01992,ko:K19341	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC2_membrane_2
CMS2_k127_866429_11	1047013.AQSP01000128_gene416	6.203e-109	361.0	COG1131@1|root,COG1131@2|Bacteria,2NQRI@2323|unclassified Bacteria	2|Bacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_866429_51	264199.stu0916	0.0008097	47.0	COG1813@1|root,COG1813@2|Bacteria	2|Bacteria	K	peptidyl-tyrosine sulfation	-	-	-	ko:K15773	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3,HTH_31
CMS2_k127_866429_4	1121403.AUCV01000021_gene3571	9.954e-151	488.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,42P1M@68525|delta/epsilon subdivisions,2WKJ2@28221|Deltaproteobacteria,2MJ05@213118|Desulfobacterales	28221|Deltaproteobacteria	O	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
CMS2_k127_866429_5	714943.Mucpa_6874	3.52e-131	431.0	COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,1INN3@117747|Sphingobacteriia	976|Bacteroidetes	E	PFAM Aminotransferase class I and II	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_866429_48	290397.Adeh_1845	5.1e-07	59.0	28R8P@1|root,2ZDNC@2|Bacteria,1PBH5@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_866766_9	883103.HMPREF9703_00360	6.729e-05	48.0	COG4980@1|root,COG4980@2|Bacteria,1VFY7@1239|Firmicutes,4HNWV@91061|Bacilli,27GKY@186828|Carnobacteriaceae	91061|Bacilli	S	YtxH-like protein	ytxH	-	-	-	-	-	-	-	-	-	-	-	YtxH
CMS2_k127_866766_6	1304874.JAFY01000002_gene350	8.049e-95	329.0	COG3437@1|root,COG3920@1|root,COG3437@2|Bacteria,COG3920@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	EAL,GGDEF,HATPase_c,HisKA_2,PAS_4,PAS_9,Response_reg
CMS2_k127_866766_0	483219.LILAB_23565	0.0	1037.0	COG0308@1|root,COG0308@2|Bacteria,1NQIW@1224|Proteobacteria,4391T@68525|delta/epsilon subdivisions,2X47D@28221|Deltaproteobacteria,2YYES@29|Myxococcales	28221|Deltaproteobacteria	E	Phospholipase B	-	-	-	-	-	-	-	-	-	-	-	-	Phospholip_B
CMS2_k127_866766_8	649638.Trad_1784	3.935e-92	310.0	2A1VH@1|root,30Q4S@2|Bacteria,1WMIG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_866766_4	398512.JQKC01000009_gene566	1.625e-118	400.0	COG1680@1|root,COG4615@1|root,COG1680@2|Bacteria,COG4615@2|Bacteria,1TRPT@1239|Firmicutes,2495H@186801|Clostridia,3WHRQ@541000|Ruminococcaceae	186801|Clostridia	PQV	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,Beta-lactamase,DUF302
CMS2_k127_866766_5	485918.Cpin_6090	2.965e-116	385.0	COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	1.10.3.14	ko:K00425,ko:K07245,ko:K08738	ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00153,M00595	R10151,R11325	RC00061,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000,ko02000	3.D.4.3,3.D.4.6,9.B.62.1	-	-	AhpC-TSA,CopD,Cyt_bd_oxida_I,Cytochrome_CBB3
CMS2_k127_866766_1	869213.JCM21142_83128	6.925e-177	566.0	COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria,4NZYJ@976|Bacteroidetes	976|Bacteroidetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
CMS2_k127_866766_2	1047013.AQSP01000126_gene2740	2.093e-171	569.0	COG2866@1|root,COG2866@2|Bacteria,2NQNH@2323|unclassified Bacteria	2|Bacteria	E	Zinc carboxypeptidase	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
CMS2_k127_866766_3	1047013.AQSP01000125_gene2640	4.374e-165	527.0	COG2211@1|root,COG2211@2|Bacteria,2NPEZ@2323|unclassified Bacteria	2|Bacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1,Sugar_tr
CMS2_k127_866766_7	1123373.ATXI01000002_gene730	5.791e-93	314.0	COG0556@1|root,COG0556@2|Bacteria,2GHAD@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
CMS2_k127_879484_0	1009370.ALO_00935	0.0	2018.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4H4TB@909932|Negativicutes	1239|Firmicutes	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	srfAA	-	-	ko:K15654,ko:K15655,ko:K16119,ko:K16120	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
CMS2_k127_896960_4	755731.Clo1100_2632	0.0	1835.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_896960_9	1196323.ALKF01000205_gene4114	0.0	1369.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_896960_2	509191.AEDB02000083_gene5154	0.0	1983.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyltransferase,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_31,NAD_binding_4,PP-binding,ketoacyl-synt
CMS2_k127_896960_5	1196323.ALKF01000205_gene4114	0.0	1674.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_896960_12	1174528.JH992890_gene591	3.779e-214	683.0	COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria	2|Bacteria	O	carbamoyl transferase, NodU family	nolO	-	-	ko:K00612,ko:K16035	ko01051,ko01052,ko01130,map01051,map01052,map01130	-	R09853,R09858	RC00055,RC02840	ko00000,ko00001,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS2_k127_896960_0	755731.Clo1100_0890	0.0	2123.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_896960_7	1195236.CTER_0312	0.0	1508.0	COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_896960_3	755731.Clo1100_0890	0.0	1970.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_896960_10	1195236.CTER_0312	0.0	1322.0	COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_896960_8	1195236.CTER_0312	0.0	1475.0	COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_896960_1	755731.Clo1100_0890	0.0	2001.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS2_k127_896960_6	1034769.KB910518_gene3533	0.0	1605.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS2_k127_896960_15	246197.MXAN_3633	1.061e-57	218.0	COG2308@1|root,COG2308@2|Bacteria,1NKKV@1224|Proteobacteria	1224|Proteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_896960_13	246197.MXAN_3633	2.312e-66	244.0	COG2308@1|root,COG2308@2|Bacteria,1NKKV@1224|Proteobacteria	1224|Proteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_896960_14	246197.MXAN_3633	1.319e-58	222.0	COG2308@1|root,COG2308@2|Bacteria,1NKKV@1224|Proteobacteria	1224|Proteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_896960_11	394503.Ccel_2381	6.98e-292	943.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,B12-binding,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_31,PP-binding,ketoacyl-synt
## 6242 queries scanned
## Total time (seconds): 554.5231354236603
## Rate: 11.26 q/s