## Sat Nov  9 01:28:07 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bins_4635/CMS2_bin.67.fa -m mmseqs --itype genome -o CMS2_bin.67 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/CMS2_bin.67 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
CMS2_k127_1017614_10	234267.Acid_5028	2.86e-44	169.0	COG0477@1|root,COG2814@2|Bacteria,3Y34C@57723|Acidobacteria	57723|Acidobacteria	EGP	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
CMS2_k127_1017614_2	595460.RRSWK_06070	1.727e-181	584.0	COG0673@1|root,COG0673@2|Bacteria,2IXJ0@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_1017614_6	1047013.AQSP01000137_gene518	2.316e-76	276.0	COG0664@1|root,COG3264@1|root,COG0664@2|Bacteria,COG3264@2|Bacteria	2|Bacteria	M	cellular water homeostasis	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,TM_helix,cNMP_binding
CMS2_k127_1017614_11	883080.HMPREF9697_00738	6.416e-32	136.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,2U14Z@28211|Alphaproteobacteria,3JSHK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CMS2_k127_1017614_1	335543.Sfum_2382	6.86e-196	632.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MRAM@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
CMS2_k127_1017614_5	335543.Sfum_2381	1.563e-91	312.0	COG4783@1|root,COG4783@2|Bacteria,1R84W@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CMS2_k127_1017614_14	335543.Sfum_2380	2.163e-22	104.0	COG3807@1|root,COG3807@2|Bacteria	2|Bacteria	S	protein conserved in bacteria	yrvJ	-	3.2.1.96,3.4.17.14,3.5.1.28	ko:K01227,ko:K01447,ko:K01448,ko:K06385,ko:K07260,ko:K11060,ko:K11062,ko:K21472	ko00511,ko00550,ko01100,ko01502,ko01503,ko02020,map00511,map00550,map01100,map01502,map01503,map02020	M00651,M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02042,ko03036	-	-	-	Amidase_3,Glucosaminidase,NLPC_P60,SH3_3,SH3_4
CMS2_k127_1017614_9	1396141.BATP01000056_gene3291	1.854e-46	183.0	2DN4X@1|root,32VIM@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3616)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3616,Phytase-like
CMS2_k127_1017614_0	1396141.BATP01000034_gene4230	7.967e-213	687.0	COG3345@1|root,COG3345@2|Bacteria,46XPU@74201|Verrucomicrobia,2IWC9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	Melibiase
CMS2_k127_1017614_7	1408452.JAGZ01000014_gene2343	1.125e-60	226.0	COG4948@1|root,COG4948@2|Bacteria,2GKSK@201174|Actinobacteria,2381D@1762|Mycobacteriaceae	201174|Actinobacteria	M	Mandelate racemase muconate lactonizing enzyme	-	-	5.1.2.2	ko:K01781	ko00627,ko01120,map00627,map01120	-	R03791,R04161	RC00998	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
CMS2_k127_1017614_12	96561.Dole_1791	3.563e-31	144.0	COG1044@1|root,COG1361@1|root,COG1653@1|root,COG1044@2|Bacteria,COG1361@2|Bacteria,COG1653@2|Bacteria,1N4S6@1224|Proteobacteria,43BRE@68525|delta/epsilon subdivisions,2X729@28221|Deltaproteobacteria,2MNRP@213118|Desulfobacterales	1224|Proteobacteria	G	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1017614_16	1236541.BALL01000033_gene3484	1.185e-14	88.0	COG0790@1|root,COG0790@2|Bacteria,1NFE8@1224|Proteobacteria,1SIM6@1236|Gammaproteobacteria,2Q8WB@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Sel1-like repeats.	-	-	-	-	-	-	-	-	-	-	-	-	Sel1
CMS2_k127_1017614_3	1168034.FH5T_03280	2.297e-136	462.0	COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	dppX	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
CMS2_k127_1017614_15	1142394.PSMK_12880	5.354e-17	92.0	COG2165@1|root,COG2165@2|Bacteria,2IXM1@203682|Planctomycetes	203682|Planctomycetes	NU	Protein of unknown function (DUF1559)	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_1017614_17	67332.FM21_27110	3.45e-13	83.0	COG0515@1|root,COG2755@1|root,COG0515@2|Bacteria,COG2755@2|Bacteria,2GIV0@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PQQ_2,PQQ_3,Pkinase
CMS2_k127_1017614_13	717606.PaecuDRAFT_1859	3.309e-24	119.0	COG2017@1|root,COG2017@2|Bacteria,1V23E@1239|Firmicutes,4HD1D@91061|Bacilli,26S9G@186822|Paenibacillaceae	91061|Bacilli	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1017614_18	521674.Plim_0161	3.59e-11	74.0	COG2165@1|root,COG2165@2|Bacteria,2IYXM@203682|Planctomycetes	203682|Planctomycetes	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_1017614_19	530564.Psta_0316	1.566e-10	71.0	COG2165@1|root,COG2165@2|Bacteria,2IYEW@203682|Planctomycetes	203682|Planctomycetes	NU	Protein of unknown function (DUF1559)	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_1017614_4	1259795.ARJK01000004_gene1341	4.872e-107	363.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,42G7V@68295|Thermoanaerobacterales	186801|Clostridia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	ko:K13274,ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,CW_binding_2,Peptidase_S8,SLH
CMS2_k127_1017614_8	928724.SacglDRAFT_02849	2e-57	210.0	COG1192@1|root,COG1192@2|Bacteria,2GJX3@201174|Actinobacteria,4DXSW@85010|Pseudonocardiales	201174|Actinobacteria	D	involved in chromosome partitioning	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS2_k127_102059_29	1142394.PSMK_04880	3.081e-12	77.0	COG2165@1|root,COG2165@2|Bacteria,2IY1V@203682|Planctomycetes	203682|Planctomycetes	NU	TIGRFAM prepilin-type N-terminal cleavage methylation domain	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_102059_17	314230.DSM3645_23361	3.121e-53	200.0	COG0030@1|root,COG0030@2|Bacteria,2IYD7@203682|Planctomycetes	203682|Planctomycetes	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
CMS2_k127_102059_8	237368.SCABRO_03028	5.974e-78	274.0	COG1995@1|root,COG1995@2|Bacteria,2IYEZ@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the PdxA family	pdxA	-	1.1.1.408,1.1.1.409	ko:K22024	-	-	-	-	ko00000,ko01000	-	-	-	PdxA
CMS2_k127_102059_19	247490.KSU1_D0527	1.305e-47	178.0	COG0307@1|root,COG0307@2|Bacteria,2IZ6H@203682|Planctomycetes	203682|Planctomycetes	H	riboflavin synthase alpha chain	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
CMS2_k127_102059_14	1499967.BAYZ01000177_gene5729	4.133e-62	227.0	COG0207@1|root,COG0207@2|Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
CMS2_k127_102059_18	1267535.KB906767_gene720	8.931e-53	196.0	COG0760@1|root,COG0760@2|Bacteria,3Y8EB@57723|Acidobacteria,2JNN9@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM PPIC-type	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
CMS2_k127_102059_20	1123242.JH636434_gene4072	5.928e-43	163.0	COG1327@1|root,COG1327@2|Bacteria,2IZQ3@203682|Planctomycetes	203682|Planctomycetes	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
CMS2_k127_102059_31	237368.SCABRO_03335	6.834e-11	71.0	COG1328@1|root,COG1328@2|Bacteria	2|Bacteria	F	CTP reductase activity	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
CMS2_k127_102059_9	269799.Gmet_2052	4.194e-76	265.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2WIUB@28221|Deltaproteobacteria,43U4M@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
CMS2_k127_102059_11	886293.Sinac_7456	1.006e-69	246.0	COG0142@1|root,COG0142@2|Bacteria,2IX56@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
CMS2_k127_102059_12	1150600.ADIARSV_1139	7.774e-64	228.0	COG3408@1|root,COG3408@2|Bacteria,4NGZM@976|Bacteroidetes,1IVM9@117747|Sphingobacteriia	976|Bacteroidetes	G	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,Glyco_hydro_100,S6PP
CMS2_k127_102059_32	266834.SM_b21054	5.261e-06	53.0	COG0500@1|root,COG0500@2|Bacteria,1QY5V@1224|Proteobacteria,2UKTW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_102059_30	500153.JOEK01000021_gene69	3.301e-11	76.0	COG5434@1|root,COG5434@2|Bacteria,2IEIN@201174|Actinobacteria	201174|Actinobacteria	M	Pectate lyase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Pectate_lyase_3
CMS2_k127_102059_2	234267.Acid_4074	6.635e-192	611.0	COG5316@1|root,COG5316@2|Bacteria,3Y4FP@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
CMS2_k127_102059_0	886293.Sinac_5964	3.506e-279	874.0	COG5029@1|root,COG5029@2|Bacteria,2J2JG@203682|Planctomycetes	203682|Planctomycetes	O	Prenyltransferase and squalene oxidase repeat	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
CMS2_k127_102059_6	706587.Desti_0638	1.25e-102	345.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,42QIH@68525|delta/epsilon subdivisions,2WIR8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057,ko:K10440	ko02010,map02010	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
CMS2_k127_102059_5	1273538.G159_00300	1.843e-140	462.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli,26DU6@186818|Planococcaceae	91061|Bacilli	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	rbsA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015608,GO:0015611,GO:0015749,GO:0015750,GO:0015752,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043211,GO:0043492,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
CMS2_k127_102059_7	706587.Desti_0640	3.115e-83	289.0	COG1879@1|root,COG1879@2|Bacteria,1MU95@1224|Proteobacteria,43B21@68525|delta/epsilon subdivisions,2X6G3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
CMS2_k127_102059_24	1232410.KI421428_gene1029	1.298e-30	135.0	COG3137@1|root,COG3137@2|Bacteria,1RHDT@1224|Proteobacteria,42XQR@68525|delta/epsilon subdivisions,2X2FN@28221|Deltaproteobacteria,43V6S@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
CMS2_k127_102059_21	1123508.JH636449_gene7300	6.736e-40	157.0	COG1595@1|root,COG1595@2|Bacteria,2IZ91@203682|Planctomycetes	203682|Planctomycetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_102059_33	794903.OPIT5_04135	7.329e-05	54.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_102059_16	518766.Rmar_0304	1.017e-58	218.0	COG1600@1|root,COG1600@2|Bacteria,4NFCJ@976|Bacteroidetes,1FJQT@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	4Fe-4S double cluster binding domain	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
CMS2_k127_102059_4	1303518.CCALI_02122	9.028e-174	585.0	2C33Y@1|root,33VR5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_102059_10	1003195.SCAT_4166	1.949e-74	261.0	COG0005@1|root,COG0005@2|Bacteria,2GKGG@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
CMS2_k127_102059_22	1501230.ET33_01165	6.632e-39	162.0	COG1819@1|root,COG1819@2|Bacteria,1VNYD@1239|Firmicutes,4I0S3@91061|Bacilli,270QT@186822|Paenibacillaceae	91061|Bacilli	CG	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
CMS2_k127_102059_1	1142394.PSMK_27420	9.406e-228	719.0	COG0504@1|root,COG0504@2|Bacteria,2IXNE@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
CMS2_k127_102059_13	886293.Sinac_6103	1.405e-62	228.0	COG1212@1|root,COG1212@2|Bacteria,2IYWF@203682|Planctomycetes	203682|Planctomycetes	H	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
CMS2_k127_102059_3	509635.N824_10105	1.158e-177	571.0	COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,1IQDG@117747|Sphingobacteriia	976|Bacteroidetes	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_102059_23	1528106.JRJE01000008_gene1463	2.437e-33	141.0	COG3254@1|root,COG3254@2|Bacteria,1N1TG@1224|Proteobacteria,2UAX5@28211|Alphaproteobacteria,2JWYD@204441|Rhodospirillales	204441|Rhodospirillales	S	L-rhamnose mutarotase	-	-	-	-	-	-	-	-	-	-	-	-	rhaM
CMS2_k127_102059_26	1122237.AUGQ01000001_gene869	2.718e-26	120.0	COG3254@1|root,COG3254@2|Bacteria,2IKRX@201174|Actinobacteria,4FSRU@85023|Microbacteriaceae	201174|Actinobacteria	S	L-rhamnose mutarotase	-	-	5.1.3.32	ko:K03534	-	-	R10819	RC00563	ko00000,ko01000	-	-	-	rhaM
CMS2_k127_102059_15	1499967.BAYZ01000119_gene3201	7.102e-62	215.0	COG4154@1|root,COG4154@2|Bacteria	2|Bacteria	G	fucose binding	fucU	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016853,GO:0016854,GO:0016857,GO:0030246,GO:0036094,GO:0042806,GO:0044424,GO:0044464,GO:0048029	5.1.3.29	ko:K02431	-	-	R10764	RC00563	ko00000,ko01000	-	-	-	RbsD_FucU
CMS2_k127_102059_28	1303518.CCALI_01450	1.127e-13	81.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02679	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_1028876_1	1047013.AQSP01000133_gene2141	5.921e-216	692.0	COG2605@1|root,COG2605@2|Bacteria	2|Bacteria	G	GHMP kinase	fkp	-	2.7.1.52	ko:K05305	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R03161	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Fucokinase,GHMP_kinases_C,GHMP_kinases_N
CMS2_k127_1028876_6	926550.CLDAP_15290	4.054e-104	347.0	COG0451@1|root,COG0451@2|Bacteria,2G7TT@200795|Chloroflexi	200795|Chloroflexi	M	Male sterility protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
CMS2_k127_1028876_8	1121904.ARBP01000022_gene3521	3.468e-53	211.0	COG1397@1|root,COG1397@2|Bacteria,4NG36@976|Bacteroidetes,47K8Y@768503|Cytophagia	976|Bacteroidetes	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
CMS2_k127_1028876_12	1504672.669785010	1.334e-11	78.0	COG3266@1|root,COG3391@1|root,COG5297@1|root,COG3266@2|Bacteria,COG3391@2|Bacteria,COG5297@2|Bacteria,1QWRQ@1224|Proteobacteria	1224|Proteobacteria	M	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Abhydrolase_3,Cadherin-like,Cadherin_3,TIG,VCBS
CMS2_k127_1028876_11	4533.OB01G18130.1	4.383e-14	79.0	2AJBI@1|root,2RZ6Q@2759|Eukaryota,37UHN@33090|Viridiplantae,3GIQ7@35493|Streptophyta,3KZ3G@4447|Liliopsida,3IH2H@38820|Poales	35493|Streptophyta	S	Late embryogenesis abundant protein	-	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006952,GO:0008150,GO:0009314,GO:0009416,GO:0009605,GO:0009607,GO:0009611,GO:0009620,GO:0009628,GO:0009642,GO:0009644,GO:0016020,GO:0043207,GO:0044424,GO:0044444,GO:0044464,GO:0048046,GO:0050832,GO:0050896,GO:0051704,GO:0051707,GO:0071944,GO:0098542	-	-	-	-	-	-	-	-	-	-	LEA_2
CMS2_k127_1028876_2	344747.PM8797T_18876	7.468e-197	625.0	COG3119@1|root,COG3119@2|Bacteria,2J2DZ@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.8	ko:K01134	ko00600,ko04142,map00600,map04142	-	R04856	RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
CMS2_k127_1028876_3	314230.DSM3645_24145	7.915e-192	610.0	COG3119@1|root,COG3119@2|Bacteria,2IXIU@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.8	ko:K01134	ko00600,ko04142,map00600,map04142	-	R04856	RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
CMS2_k127_1028876_0	756272.Plabr_0079	2.294e-243	763.0	COG3119@1|root,COG3119@2|Bacteria,2IWVY@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS2_k127_1028876_4	1121904.ARBP01000017_gene5153	4.722e-164	531.0	COG3119@1|root,COG3119@2|Bacteria,4NEFN@976|Bacteroidetes,47KSF@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF4994,Sulfatase
CMS2_k127_1028876_5	756272.Plabr_2404	6.144e-141	460.0	COG3119@1|root,COG3119@2|Bacteria,2IY75@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.8	ko:K01134	ko00600,ko04142,map00600,map04142	-	R04856	RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS2_k127_1028876_9	497964.CfE428DRAFT_2391	5.76e-30	125.0	COG3296@1|root,COG3296@2|Bacteria,46T8B@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF4870)	-	-	-	ko:K09940	-	-	-	-	ko00000	-	-	-	DUF4870
CMS2_k127_1028876_10	1303518.CCALI_00133	5.502e-19	99.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	galA	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_4_9,CBM_6,DUF1565
CMS2_k127_1028876_7	237368.SCABRO_03733	3.843e-67	234.0	COG0428@1|root,COG0428@2|Bacteria,2J10N@203682|Planctomycetes	203682|Planctomycetes	P	transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
CMS2_k127_1056181_4	929712.KI912613_gene3538	2.096e-10	70.0	COG0582@1|root,COG0582@2|Bacteria,2I7A6@201174|Actinobacteria,4CSUJ@84995|Rubrobacteria	84995|Rubrobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
CMS2_k127_1056181_6	1379698.RBG1_1C00001G1696	0.0004132	43.0	COG0590@1|root,COG0590@2|Bacteria,2NPM7@2323|unclassified Bacteria	2|Bacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	3.5.4.1,3.5.4.33	ko:K01485,ko:K11991	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922,R10223	RC00074,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam
CMS2_k127_1056181_5	314230.DSM3645_10342	5.689e-07	59.0	COG0582@1|root,COG0582@2|Bacteria,2IZ6W@203682|Planctomycetes	203682|Planctomycetes	L	viral genome integration into host DNA	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
CMS2_k127_1056181_2	1499967.BAYZ01000065_gene6085	5.182e-92	315.0	COG2423@1|root,COG2423@2|Bacteria,2NPI5@2323|unclassified Bacteria	2|Bacteria	E	Ornithine cyclodeaminase/mu-crystallin family	rapL	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
CMS2_k127_1056181_1	1499967.BAYZ01000130_gene2591	4.127e-195	623.0	COG1760@1|root,COG1760@2|Bacteria,2NQRY@2323|unclassified Bacteria	2|Bacteria	E	Serine dehydratase alpha chain	-	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
CMS2_k127_1056181_3	1499967.BAYZ01000065_gene6085	1.274e-87	300.0	COG2423@1|root,COG2423@2|Bacteria,2NPI5@2323|unclassified Bacteria	2|Bacteria	E	Ornithine cyclodeaminase/mu-crystallin family	rapL	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
CMS2_k127_1056181_0	1210884.HG799465_gene12236	9.535e-287	900.0	COG1506@1|root,COG1506@2|Bacteria,2IYRT@203682|Planctomycetes	203682|Planctomycetes	E	Dipeptidyl peptidase IV (DPP IV)	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
CMS2_k127_1063619_4	237368.SCABRO_00909	8.128e-24	105.0	COG0103@1|root,COG0103@2|Bacteria,2J01J@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
CMS2_k127_1063619_3	2325.TKV_c20230	3.763e-52	191.0	COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia,42GCE@68295|Thermoanaerobacterales	186801|Clostridia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
CMS2_k127_1063619_7	596152.DesU5LDRAFT_0992	9.169e-06	55.0	COG1366@1|root,COG1366@2|Bacteria,1Q1IS@1224|Proteobacteria,437AN@68525|delta/epsilon subdivisions,2X2F0@28221|Deltaproteobacteria,2MCUE@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS2_k127_1063619_5	290318.Cvib_0162	5.562e-14	78.0	COG0724@1|root,COG0724@2|Bacteria,1FE64@1090|Chlorobi	1090|Chlorobi	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS2_k127_1063619_1	481448.Minf_1330	1.675e-130	436.0	COG0297@1|root,COG0297@2|Bacteria,46Z3D@74201|Verrucomicrobia,37H6N@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	G	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_1063619_2	1121403.AUCV01000006_gene427	1.383e-124	414.0	2DUCW@1|root,33Q17@2|Bacteria	2|Bacteria	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_1063619_8	309799.DICTH_0269	0.0005006	52.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	pfbA	-	-	ko:K13925	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Beta_helix,CW_binding_1,F5_F8_type_C,Glyco_hydro_28,Pectate_lyase_3,YSIRK_signal
CMS2_k127_1063619_6	105559.Nwat_1544	7.112e-06	48.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1063619_0	575540.Isop_1592	1.652e-310	971.0	COG0209@1|root,COG0209@2|Bacteria,2IX3H@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
CMS2_k127_1071402_7	1210884.HG799464_gene10458	5.919e-05	56.0	COG1277@1|root,COG1277@2|Bacteria,2J3Y5@203682|Planctomycetes	203682|Planctomycetes	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1071402_8	1303518.CCALI_00827	6.713e-05	56.0	COG1668@1|root,COG1668@2|Bacteria	2|Bacteria	CP	transmembrane transport	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2,ABC2_membrane_3
CMS2_k127_1071402_5	243090.RB1216	9.516e-08	65.0	COG1277@1|root,COG1277@2|Bacteria,2IY6H@203682|Planctomycetes	203682|Planctomycetes	CP	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
CMS2_k127_1071402_2	525904.Tter_0973	4.788e-103	350.0	COG3842@1|root,COG3842@2|Bacteria,2NNU0@2323|unclassified Bacteria	2|Bacteria	E	ATPases associated with a variety of cellular activities	ugpC	-	-	ko:K10112,ko:K10195	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00202,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.11	-	iJN678.ggtA	ABC_tran,TOBE,TOBE_2
CMS2_k127_1071402_3	1304866.K413DRAFT_2101	2.933e-33	149.0	28J61@1|root,2Z91S@2|Bacteria,1UYHJ@1239|Firmicutes,24EVG@186801|Clostridia,36HUS@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_101,Glyco_hydro_129
CMS2_k127_1071402_4	1220534.B655_1288	5.408e-16	88.0	COG0671@1|root,arCOG03056@2157|Archaea	2157|Archaea	I	PFAM phosphoesterase, PA-phosphatase related	sepP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
CMS2_k127_1071402_1	545695.TREAZ_2513	2.541e-123	415.0	COG2730@1|root,COG2730@2|Bacteria,2J89M@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase
CMS2_k127_1071402_6	316067.Geob_0814	6.627e-07	60.0	COG1361@1|root,COG1520@1|root,COG1657@1|root,COG4257@1|root,COG4733@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG1657@2|Bacteria,COG4257@2|Bacteria,COG4733@2|Bacteria,1QYWJ@1224|Proteobacteria,43CDC@68525|delta/epsilon subdivisions,2X7P6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS2_k127_1071402_0	761193.Runsl_2743	2.155e-135	438.0	COG3356@1|root,COG3356@2|Bacteria,4NHGJ@976|Bacteroidetes,47N67@768503|Cytophagia	976|Bacteroidetes	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_109185_3	1120950.KB892803_gene1443	4.722e-10	64.0	COG1874@1|root,COG1874@2|Bacteria,2ID2W@201174|Actinobacteria,4DTFQ@85009|Propionibacteriales	201174|Actinobacteria	G	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
CMS2_k127_109185_1	929713.NIASO_00020	3.361e-104	355.0	COG3119@1|root,COG3119@2|Bacteria,4NGCH@976|Bacteroidetes,1IXWA@117747|Sphingobacteriia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_109185_0	1123277.KB893174_gene5922	1.054e-122	416.0	COG2152@1|root,COG2152@2|Bacteria,4PN24@976|Bacteroidetes,47MK6@768503|Cytophagia	976|Bacteroidetes	G	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_109185_2	926550.CLDAP_27370	1.218e-20	107.0	COG1520@1|root,COG1520@2|Bacteria,2G945@200795|Chloroflexi	200795|Chloroflexi	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1093961_20	1123277.KB893176_gene3707	4.425e-06	49.0	COG2173@1|root,COG2173@2|Bacteria	2|Bacteria	M	zinc D-Ala-D-Ala carboxypeptidase activity	-	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15,SH3_3,SH3_4,VanY
CMS2_k127_1093961_21	272560.BPSL0699	0.0001133	51.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2VK2K@28216|Betaproteobacteria,1K08I@119060|Burkholderiaceae	28216|Betaproteobacteria	M	mandelate racemase muconate lactonizing	dgoD	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
CMS2_k127_1093961_11	1121396.KB893024_gene3903	6.485e-112	384.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,42RXF@68525|delta/epsilon subdivisions,2WNF1@28221|Deltaproteobacteria,2MM2H@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	arnT	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
CMS2_k127_1093961_18	387093.SUN_0089	3.815e-52	198.0	2BT8X@1|root,32NEA@2|Bacteria,1RGSX@1224|Proteobacteria,42S0P@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Predicted periplasmic lipoprotein (DUF2279)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2279
CMS2_k127_1093961_16	321846.PS417_13825	5.458e-55	214.0	COG1807@1|root,COG1807@2|Bacteria,1NTCC@1224|Proteobacteria	1224|Proteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
CMS2_k127_1093961_10	1121403.AUCV01000015_gene4718	1.184e-112	372.0	COG0726@1|root,COG0726@2|Bacteria,1N8Q4@1224|Proteobacteria,42RRH@68525|delta/epsilon subdivisions,2WNID@28221|Deltaproteobacteria,2MMUU@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Polysaccharide deacetylase	arnD	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0882	Polysacc_deac_1
CMS2_k127_1093961_1	1121396.KB893024_gene3901	8.737e-305	949.0	COG0223@1|root,COG0451@1|root,COG0223@2|Bacteria,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42QC6@68525|delta/epsilon subdivisions,2WIRV@28221|Deltaproteobacteria,2MMI1@213118|Desulfobacterales	28221|Deltaproteobacteria	GJM	Formyl transferase, C-terminal domain	arnA	-	1.1.1.305,2.1.2.13	ko:K10011,ko:K12449	ko00520,ko01100,ko01503,map00520,map01100,map01503	M00721,M00761	R01384,R01386,R07658,R07660	RC00026,RC00508,RC01575,RC01811,RC01812	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase,Formyl_trans_C,Formyl_trans_N
CMS2_k127_1093961_8	571.MC52_06535	1.272e-127	419.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides	arnC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0044464,GO:0071944,GO:0099621	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	iAPECO1_1312.APECO1_4307,iE2348C_1286.E2348C_2398,iECABU_c1320.ECABU_c25880,iECED1_1282.ECED1_2720,iECOK1_1307.ECOK1_2490,iECP_1309.ECP_2297,iECS88_1305.ECS88_2403,iLF82_1304.LF82_0138,iNRG857_1313.NRG857_11430,iUMN146_1321.UM146_05530,iUTI89_1310.UTI89_C2536,ic_1306.c2796	Glycos_transf_2
CMS2_k127_1093961_5	1121396.KB893024_gene3899	4.722e-164	527.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MTX@68525|delta/epsilon subdivisions,2WITE@28221|Deltaproteobacteria,2MIIQ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	arnB	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_1093961_14	1211112.ALJC01000075_gene3076	2.898e-82	296.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS2_k127_1093961_15	1382359.JIAL01000001_gene2389	2.061e-62	222.0	COG0745@1|root,COG0745@2|Bacteria,3Y2TP@57723|Acidobacteria,2JHWA@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator	-	-	-	ko:K07660	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_1093961_19	1125863.JAFN01000001_gene723	1.045e-44	181.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,42QF7@68525|delta/epsilon subdivisions,2WJAU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07644	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS_9,Response_reg
CMS2_k127_1093961_13	666685.R2APBS1_2038	2.435e-83	291.0	COG1538@1|root,COG1538@2|Bacteria,1RFMJ@1224|Proteobacteria,1S8HY@1236|Gammaproteobacteria,1X7RA@135614|Xanthomonadales	135614|Xanthomonadales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_1093961_17	697282.Mettu_1422	1.319e-53	200.0	COG0845@1|root,COG0845@2|Bacteria,1PEPU@1224|Proteobacteria,1RXJ2@1236|Gammaproteobacteria,1XFSZ@135618|Methylococcales	135618|Methylococcales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
CMS2_k127_1093961_0	1047013.AQSP01000056_gene1922	0.0	1311.0	COG0841@1|root,COG0841@2|Bacteria,2NQKZ@2323|unclassified Bacteria	2|Bacteria	V	AcrB/AcrD/AcrF family	swrC	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS2_k127_1093961_2	314230.DSM3645_26724	9.333e-224	722.0	COG0457@1|root,COG0457@2|Bacteria,2IWTH@203682|Planctomycetes	203682|Planctomycetes	S	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2,TPR_16,TPR_19
CMS2_k127_1093961_9	344747.PM8797T_32255	3.06e-115	377.0	2DBN7@1|root,2ZA2Y@2|Bacteria,2IYBW@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
CMS2_k127_1093961_7	240016.ABIZ01000001_gene1383	1.087e-141	458.0	COG0714@1|root,COG0714@2|Bacteria,46TCY@74201|Verrucomicrobia,2ITSU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_3
CMS2_k127_1093961_12	497964.CfE428DRAFT_0775	4.484e-107	360.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS2_k127_1093961_6	497964.CfE428DRAFT_0777	9.983e-144	483.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
CMS2_k127_1093961_3	1210884.HG799463_gene9708	3.878e-209	702.0	COG1196@1|root,COG1196@2|Bacteria,2IYCW@203682|Planctomycetes	203682|Planctomycetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1093961_4	1123242.JH636434_gene3690	1.127e-207	674.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,2IWWQ@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
CMS2_k127_1108533_1	1469613.JT55_13250	7.293e-112	389.0	2F03P@1|root,33T7B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1108533_3	1380390.JIAT01000011_gene2883	2.714e-30	139.0	COG0028@1|root,COG0515@1|root,COG1409@1|root,COG1749@1|root,COG2374@1|root,COG3291@1|root,COG3509@1|root,COG4733@1|root,COG0028@2|Bacteria,COG0515@2|Bacteria,COG1409@2|Bacteria,COG1749@2|Bacteria,COG2374@2|Bacteria,COG3291@2|Bacteria,COG3509@2|Bacteria,COG4733@2|Bacteria,2I2X3@201174|Actinobacteria,4CSIX@84995|Rubrobacteria	84995|Rubrobacteria	N	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,fn3
CMS2_k127_1108533_6	46429.BV95_03149	2.812e-15	83.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2UC0F@28211|Alphaproteobacteria,2K5EC@204457|Sphingomonadales	204457|Sphingomonadales	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS2_k127_1108533_5	102129.Lepto7375DRAFT_7877	1.879e-18	97.0	COG2905@1|root,COG2905@2|Bacteria,1G0YW@1117|Cyanobacteria,1HA4V@1150|Oscillatoriales	1117|Cyanobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS,PAS_9
CMS2_k127_1108533_0	1403819.BATR01000191_gene6501	1.16e-225	709.0	COG3119@1|root,COG3119@2|Bacteria,46S9C@74201|Verrucomicrobia,2ITNC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
CMS2_k127_1108533_2	1304885.AUEY01000016_gene3053	4.008e-36	143.0	COG2816@1|root,COG2816@2|Bacteria,1QYWI@1224|Proteobacteria,42UTR@68525|delta/epsilon subdivisions,2WR0I@28221|Deltaproteobacteria,2MM0M@213118|Desulfobacterales	28221|Deltaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS2_k127_1108533_4	1249975.JQLP01000005_gene1651	4.331e-29	133.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP_2,Kelch_1,Laminin_G_3
CMS2_k127_1108533_7	1536775.H70737_22865	4.206e-12	79.0	COG1409@1|root,COG4124@1|root,COG1409@2|Bacteria,COG4124@2|Bacteria,1V0UJ@1239|Firmicutes,4HGW4@91061|Bacilli,26U0Y@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 26 family	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Glyco_hydro_26,PA14
CMS2_k127_110907_2	856793.MICA_1642	5.381e-07	63.0	COG1520@1|root,COG3534@1|root,COG1520@2|Bacteria,COG3534@2|Bacteria	2|Bacteria	G	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43,Laminin_G_3,PQQ_2
CMS2_k127_110907_1	1123276.KB893313_gene3810	2.095e-35	154.0	COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,47MTM@768503|Cytophagia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
CMS2_k127_110907_0	452637.Oter_1389	3.582e-134	464.0	COG0515@1|root,COG0515@2|Bacteria,46VB0@74201|Verrucomicrobia,3K8AK@414999|Opitutae	414999|Opitutae	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_1126995_2	243090.RB940	1.399e-61	214.0	COG3386@1|root,COG3386@2|Bacteria,2J2MK@203682|Planctomycetes	203682|Planctomycetes	G	BNR repeat-containing family member	-	-	-	-	-	-	-	-	-	-	-	-	BNR_4
CMS2_k127_1126995_1	1499967.BAYZ01000177_gene5725	1.365e-164	542.0	COG1053@1|root,COG1053@2|Bacteria,2NQEG@2323|unclassified Bacteria	2|Bacteria	C	FAD binding domain	-	-	1.4.3.16,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00278,ko:K03388	ko00250,ko00680,ko00760,ko01100,ko01120,ko01200,map00250,map00680,map00760,map01100,map01120,map01200	M00115,M00356,M00357,M00563,M00567	R00357,R00481,R04540,R11928,R11931,R11943,R11944	RC00006,RC00011,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
CMS2_k127_1126995_0	377629.TERTU_0897	1.243e-165	528.0	COG0524@1|root,COG0524@2|Bacteria,1QNWF@1224|Proteobacteria,1RRZR@1236|Gammaproteobacteria,2PNXE@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
CMS2_k127_1126995_3	344747.PM8797T_04555	2.221e-53	194.0	COG0182@1|root,COG0182@2|Bacteria,2IWRJ@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
CMS2_k127_1137653_7	497964.CfE428DRAFT_5426	6.399e-76	280.0	COG1680@1|root,COG1680@2|Bacteria,46WGY@74201|Verrucomicrobia	74201|Verrucomicrobia	V	COG1680 Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1137653_10	1232437.KL662004_gene4524	6.585e-17	95.0	2EKQJ@1|root,33EEC@2|Bacteria,1Q6FB@1224|Proteobacteria,4331H@68525|delta/epsilon subdivisions,2WXFD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1137653_8	926550.CLDAP_19500	7.795e-48	196.0	COG0584@1|root,COG0823@1|root,COG3210@1|root,COG4886@1|root,COG0584@2|Bacteria,COG0823@2|Bacteria,COG3210@2|Bacteria,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	3.1.4.46	ko:K01126,ko:K21449	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000,ko02000	1.B.40.2	-	-	GDPD_2
CMS2_k127_1137653_0	314230.DSM3645_05315	1.086e-229	722.0	COG3119@1|root,COG3119@2|Bacteria,2IXMP@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_1137653_6	868595.Desca_1979	7.806e-91	305.0	COG0708@1|root,COG0708@2|Bacteria,1TPFB@1239|Firmicutes,24849@186801|Clostridia,264NP@186807|Peptococcaceae	186801|Clostridia	L	PFAM Endonuclease Exonuclease phosphatase	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
CMS2_k127_1137653_9	264732.Moth_1653	5.809e-40	152.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,42GCN@68295|Thermoanaerobacterales	186801|Clostridia	K	TIGRFAM transcriptional regulator, Rrf2 family	cymR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS2_k127_1137653_2	404589.Anae109_2487	4.605e-118	389.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,2YWJD@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_1137653_3	573413.Spirs_1684	4.646e-110	364.0	COG1045@1|root,COG1045@2|Bacteria,2J73S@203691|Spirochaetes	203691|Spirochaetes	E	Serine acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
CMS2_k127_1137653_4	1121468.AUBR01000008_gene2063	7.738e-105	349.0	COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,247IJ@186801|Clostridia,42F86@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12020	NadA
CMS2_k127_1137653_1	1232410.KI421413_gene795	7.543e-191	604.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2X70U@28221|Deltaproteobacteria,43S7X@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metY-1	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
CMS2_k127_1137653_5	335543.Sfum_2684	5.417e-98	324.0	COG0694@1|root,COG0822@1|root,COG1251@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,COG1251@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria,2MQ59@213462|Syntrophobacterales	28221|Deltaproteobacteria	CO	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	nifU	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
CMS2_k127_1153452_0	1288963.ADIS_0826	2.273e-99	342.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS2_k127_1153452_3	234267.Acid_4520	1.72e-14	83.0	COG1335@1|root,COG1335@2|Bacteria,3Y7ZP@57723|Acidobacteria	57723|Acidobacteria	Q	Isochorismatase family	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
CMS2_k127_1153452_2	1142394.PSMK_25540	5.941e-41	160.0	COG0220@1|root,COG0220@2|Bacteria,2IZJM@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
CMS2_k127_1153452_1	1267535.KB906767_gene2278	2.511e-58	222.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
CMS2_k127_1153452_4	1434325.AZQN01000002_gene1136	3.22e-14	78.0	COG1413@1|root,COG3119@1|root,COG1413@2|Bacteria,COG3119@2|Bacteria,4NEZJ@976|Bacteroidetes,47NF5@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,Sulfatase
CMS2_k127_1164482_0	338966.Ppro_0084	2.581e-46	187.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,43T8P@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4150,RHS,RHS_repeat,Transglut_core
CMS2_k127_1164482_1	1280390.CBQR020000048_gene957	8.899e-43	179.0	COG5184@1|root,COG5184@2|Bacteria,1UZD4@1239|Firmicutes,4HD48@91061|Bacilli,26VBQ@186822|Paenibacillaceae	91061|Bacilli	DZ	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like,RCC1_2,SLH
CMS2_k127_1164482_2	1177594.MIC448_830010	4.843e-29	135.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CarboxypepD_reg,HemolysinCabind
CMS2_k127_118053_2	1121459.AQXE01000005_gene1549	2.459e-124	411.0	COG0297@1|root,COG0297@2|Bacteria,1R6U0@1224|Proteobacteria,42Q1W@68525|delta/epsilon subdivisions,2WJXW@28221|Deltaproteobacteria,2M8ZZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Starch synthase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glyco_transf_5,Glycos_transf_1
CMS2_k127_118053_0	563192.HMPREF0179_03201	4.229e-166	531.0	COG1449@1|root,COG1449@2|Bacteria,1R8JX@1224|Proteobacteria,42QA5@68525|delta/epsilon subdivisions,2WMM5@28221|Deltaproteobacteria,2M9GJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	3.2.1.1	ko:K07405	ko00500,ko01100,map00500,map01100	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH57	-	Glyco_hydro_57
CMS2_k127_118053_1	1304284.L21TH_1162	3.312e-134	453.0	COG3408@1|root,COG3408@2|Bacteria,1TPX8@1239|Firmicutes,249BI@186801|Clostridia,36E5M@31979|Clostridiaceae	186801|Clostridia	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
CMS2_k127_118053_4	768671.ThimaDRAFT_0140	2.633e-18	92.0	COG4566@1|root,COG4566@2|Bacteria,1RGE8@1224|Proteobacteria,1S4T1@1236|Gammaproteobacteria,1X2B8@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS2_k127_1190609_2	452637.Oter_2946	5.533e-114	378.0	COG5512@1|root,COG5512@2|Bacteria	2|Bacteria	L	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	Collagen_bind_2,DUF4038,DUF5060,DUF721
CMS2_k127_1190609_4	1488328.JMCL01000010_gene112	8.816e-75	277.0	COG2273@1|root,COG2273@2|Bacteria,1R8TW@1224|Proteobacteria,1RRPY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
CMS2_k127_1190609_3	1403819.BATR01000125_gene4449	2.795e-93	332.0	2CEMG@1|root,346QA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
CMS2_k127_1190609_5	1408224.SAMCCGM7_c3749	2.94e-68	251.0	COG2730@1|root,COG2730@2|Bacteria,1R544@1224|Proteobacteria,2U1MT@28211|Alphaproteobacteria,4BD0S@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Putative collagen-binding domain of a collagenase	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038
CMS2_k127_1190609_0	452637.Oter_3064	5.292e-170	546.0	COG2730@1|root,COG2730@2|Bacteria,46WXN@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Protein of unknown function (DUF4038)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038
CMS2_k127_1190609_9	1121875.KB907547_gene3432	0.0002677	46.0	28WBK@1|root,2ZIC0@2|Bacteria,4P7B5@976|Bacteroidetes,1IBE5@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1190609_1	42256.RradSPS_2475	2.283e-141	477.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2GKFE@201174|Actinobacteria,4CRQ6@84995|Rubrobacteria	84995|Rubrobacteria	C	COG COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit Energy production and conversion	-	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K11381,ko:K21417	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS2_k127_1190609_8	1128421.JAGA01000003_gene2788	1.179e-16	81.0	COG0508@1|root,COG0508@2|Bacteria,2NNYD@2323|unclassified Bacteria	2|Bacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	pdhC	-	1.2.4.1,2.3.1.12	ko:K00162,ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R02569,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CMS2_k127_1192370_4	240015.ACP_2748	1.654e-06	57.0	COG1595@1|root,COG1595@2|Bacteria,3Y50V@57723|Acidobacteria,2JJJN@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_1192370_3	869213.JCM21142_31351	5.312e-10	73.0	COG3866@1|root,COG4447@1|root,COG3866@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1192370_1	46234.ANA_C13788	2.165e-32	146.0	COG1404@1|root,COG2911@1|root,COG2931@1|root,COG3291@1|root,COG3537@1|root,COG1404@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,COG3537@2|Bacteria,1G2N0@1117|Cyanobacteria,1HRSX@1161|Nostocales	1117|Cyanobacteria	GOQ	Calx-beta domain	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Calx-beta,DUF4114,DUF4347,HemolysinCabind,Laminin_G_3,SBP_bac_3,VCBS
CMS2_k127_1192370_2	1403819.BATR01000020_gene657	4.975e-12	75.0	COG1595@1|root,COG1595@2|Bacteria,46VNT@74201|Verrucomicrobia,2IVV9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4
CMS2_k127_1200103_8	886293.Sinac_0921	2.78e-31	128.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	3.2.1.18,3.2.1.4	ko:K01179,ko:K01186	ko00500,ko00511,ko00600,ko01100,ko04142,map00500,map00511,map00600,map01100,map04142	-	R04018,R06200,R11307,R11308	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33,GH5,GH9	-	BNR,BNR_2,CBM_2,RicinB_lectin_2
CMS2_k127_1200103_6	1472418.BBJC01000006_gene2431	8.703e-56	214.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_1200103_9	794903.OPIT5_08605	8.654e-11	72.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_1200103_10	278957.ABEA03000086_gene2490	1.18e-09	71.0	COG2165@1|root,COG2165@2|Bacteria,46Y25@74201|Verrucomicrobia,3K8TK@414999|Opitutae	414999|Opitutae	NU	Protein of unknown function (DUF1559)	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_1200103_4	459349.CLOAM0151	3.859e-74	258.0	2DCT2@1|root,32U08@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
CMS2_k127_1200103_5	546271.Selsp_0363	1.07e-67	242.0	COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,4H1XA@909932|Negativicutes	909932|Negativicutes	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
CMS2_k127_1200103_2	1379281.AVAG01000018_gene1052	7.275e-121	408.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1MUI0@1224|Proteobacteria,42MCB@68525|delta/epsilon subdivisions,2WIRJ@28221|Deltaproteobacteria,2M9KC@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	hemD	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
CMS2_k127_1200103_0	661478.OP10G_0540	7.188e-149	490.0	COG3525@1|root,COG3525@2|Bacteria	2|Bacteria	G	beta-N-acetylhexosaminidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4838,F5_F8_type_C,Glyco_hydro_67N
CMS2_k127_1200103_3	518766.Rmar_1623	1.286e-78	271.0	COG3291@1|root,COG3291@2|Bacteria,4PMYH@976|Bacteroidetes	976|Bacteroidetes	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_1200103_7	886293.Sinac_5785	1.254e-35	142.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_1200103_11	272134.KB731324_gene4224	1.469e-06	53.0	COG1502@1|root,COG1555@1|root,COG1502@2|Bacteria,COG1555@2|Bacteria,1G01I@1117|Cyanobacteria,1H79E@1150|Oscillatoriales	1117|Cyanobacteria	I	TIGRFAM Competence protein ComEA, helix-hairpin-helix	comA	-	-	-	-	-	-	-	-	-	-	-	HHH_3,PLDc_2
CMS2_k127_1200103_1	886293.Sinac_1501	1.878e-127	419.0	COG3591@1|root,COG3591@2|Bacteria,2IXPD@203682|Planctomycetes	203682|Planctomycetes	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
CMS2_k127_1208989_2	1195236.CTER_2213	1.119e-107	355.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,3WHHZ@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
CMS2_k127_1208989_4	639282.DEFDS_0963	1.588e-44	166.0	COG4747@1|root,COG4747@2|Bacteria,2GFKS@200930|Deferribacteres	200930|Deferribacteres	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
CMS2_k127_1208989_1	744872.Spica_1263	1.462e-177	565.0	COG1541@1|root,COG1541@2|Bacteria,2J5UX@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
CMS2_k127_1208989_5	224325.AF_1672	2.018e-26	115.0	COG4747@1|root,arCOG04444@2157|Archaea,2XXTI@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
CMS2_k127_1208989_3	1123248.KB893359_gene2154	7.103e-85	295.0	COG0726@1|root,COG0726@2|Bacteria,4NJK7@976|Bacteroidetes	976|Bacteroidetes	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
CMS2_k127_1208989_0	1123023.JIAI01000002_gene4757	7.67e-213	687.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4E0K4@85010|Pseudonocardiales	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349,ko:K17641	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
CMS2_k127_1214247_1	1121445.ATUZ01000019_gene2280	1.583e-74	259.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42PQM@68525|delta/epsilon subdivisions,2WJIF@28221|Deltaproteobacteria,2MGE4@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	HTH_20,Methyltransf_31
CMS2_k127_1214247_0	293826.Amet_3997	7.229e-230	728.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
CMS2_k127_1214247_2	1121405.dsmv_3545	1.443e-27	115.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,42M0Z@68525|delta/epsilon subdivisions,2WK36@28221|Deltaproteobacteria,2MJ5F@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Bile acid sodium symporter	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
CMS2_k127_121946_1	497964.CfE428DRAFT_4943	8.912e-175	572.0	COG0577@1|root,COG0577@2|Bacteria,46U6N@74201|Verrucomicrobia	74201|Verrucomicrobia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
CMS2_k127_121946_3	1168034.FH5T_01575	2.435e-120	402.0	COG1520@1|root,COG1520@2|Bacteria,4P15Y@976|Bacteroidetes,2FWBU@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2
CMS2_k127_121946_8	595460.RRSWK_06184	3.51e-54	203.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
CMS2_k127_121946_7	595460.RRSWK_06186	1.748e-65	230.0	2DVMZ@1|root,33WFQ@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_121946_4	595460.RRSWK_06187	3.217e-115	385.0	COG0348@1|root,COG0348@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	ko:K02574	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_5
CMS2_k127_121946_5	497964.CfE428DRAFT_5712	4.501e-114	394.0	COG1520@1|root,COG1520@2|Bacteria,46THI@74201|Verrucomicrobia	2|Bacteria	S	SMART Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_121946_0	555079.Toce_0242	2.327e-213	689.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42I0X@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	nuoF2	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
CMS2_k127_121946_2	595460.RRSWK_05849	4.085e-144	473.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,2J2W6@203682|Planctomycetes	203682|Planctomycetes	E	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4_20,Pyr_redox_2
CMS2_k127_121946_12	43989.cce_4844	4.523e-05	53.0	2A2DT@1|root,30QQT@2|Bacteria,1GM8B@1117|Cyanobacteria,3KJT1@43988|Cyanothece	1117|Cyanobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
CMS2_k127_121946_10	1168034.FH5T_01535	3.207e-22	104.0	COG0493@1|root,COG0493@2|Bacteria,4P2CU@976|Bacteroidetes,2FXPN@200643|Bacteroidia	976|Bacteroidetes	E	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4_20
CMS2_k127_121946_9	589865.DaAHT2_0150	2.648e-41	161.0	COG0655@1|root,COG0655@2|Bacteria,1RAK6@1224|Proteobacteria,42QS5@68525|delta/epsilon subdivisions,2WN2M@28221|Deltaproteobacteria,2MJW8@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS2_k127_121946_6	240016.ABIZ01000001_gene1539	3.01e-113	378.0	COG1520@1|root,COG1520@2|Bacteria,46TV4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_121946_11	1210884.HG799465_gene11381	3.69e-17	83.0	COG1520@1|root,COG1520@2|Bacteria,2IX03@203682|Planctomycetes	203682|Planctomycetes	S	protein kinase related protein	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_1232658_3	1227487.C474_16159	4.794e-111	380.0	arCOG02521@1|root,arCOG02521@2157|Archaea,2XVSU@28890|Euryarchaeota,23UVK@183963|Halobacteria	183963|Halobacteria	S	Glycosyl hydrolases family 28	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28
CMS2_k127_1232658_2	794903.OPIT5_04755	2.216e-117	387.0	COG2152@1|root,COG2152@2|Bacteria,46YKJ@74201|Verrucomicrobia,3K8SE@414999|Opitutae	2|Bacteria	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	2.4.1.339,2.4.1.340	ko:K20885	-	-	R11397,R11398	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
CMS2_k127_1232658_0	342610.Patl_0129	7.771e-178	578.0	COG0591@1|root,COG0591@2|Bacteria,1PNHU@1224|Proteobacteria,1S0S6@1236|Gammaproteobacteria,2Q4RI@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
CMS2_k127_1232658_1	497964.CfE428DRAFT_1603	2.279e-177	567.0	COG0673@1|root,COG0673@2|Bacteria,46TYR@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_1232658_5	1168034.FH5T_01595	1.195e-85	298.0	COG1520@1|root,COG1520@2|Bacteria,4P28I@976|Bacteroidetes,2FX0J@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_1232658_8	1173024.KI912148_gene3931	3.778e-20	96.0	2ETKY@1|root,33M4N@2|Bacteria,1GF86@1117|Cyanobacteria,1JM2E@1189|Stigonemataceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1232658_4	471854.Dfer_5253	2.828e-104	357.0	COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,47TMC@768503|Cytophagia	976|Bacteroidetes	S	Sodium:solute symporter family	sglT	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_1232658_6	118168.MC7420_6956	1.982e-55	219.0	COG4886@1|root,COG4886@2|Bacteria,1G4SR@1117|Cyanobacteria,1HAQW@1150|Oscillatoriales	1117|Cyanobacteria	G	Leucine-rich repeat	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	LRR_4,LRR_6,LRR_8
CMS2_k127_1232658_9	192952.MM_2804	5.955e-11	76.0	arCOG03499@1|root,arCOG03499@2157|Archaea	2157|Archaea	G	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Disaggr_assoc,Disaggr_repeat,PKD
CMS2_k127_1232658_7	118168.MC7420_6956	8.061e-28	129.0	COG4886@1|root,COG4886@2|Bacteria,1G4SR@1117|Cyanobacteria,1HAQW@1150|Oscillatoriales	1117|Cyanobacteria	G	Leucine-rich repeat	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	LRR_4,LRR_6,LRR_8
CMS2_k127_1232658_10	96561.Dole_2043	3.497e-09	69.0	COG1800@1|root,COG2885@1|root,COG3420@1|root,COG1800@2|Bacteria,COG2885@2|Bacteria,COG3420@2|Bacteria,1MZHI@1224|Proteobacteria,43BRC@68525|delta/epsilon subdivisions,2WUM4@28221|Deltaproteobacteria,2MN6K@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1232708_2	335543.Sfum_2158	1.023e-14	87.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
CMS2_k127_1232708_1	118168.MC7420_6956	6.939e-36	154.0	COG4886@1|root,COG4886@2|Bacteria,1G4SR@1117|Cyanobacteria,1HAQW@1150|Oscillatoriales	1117|Cyanobacteria	G	Leucine-rich repeat	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	LRR_4,LRR_6,LRR_8
CMS2_k127_1232708_5	1173028.ANKO01000089_gene3639	0.0002436	54.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CW_binding_1,VCBS
CMS2_k127_1232708_3	1123070.KB899251_gene797	2.57e-08	67.0	COG4625@1|root,COG4625@2|Bacteria	2|Bacteria	T	pathogenesis	-	-	4.2.2.23	ko:K06972,ko:K18195	-	-	-	-	ko00000,ko01000,ko01002	-	PL4	-	Autotransporter,CBM-like,DUF285,Flg_new,SLH,fn3_3
CMS2_k127_1232708_0	521674.Plim_1374	1.839e-158	528.0	COG1198@1|root,COG1198@2|Bacteria,2IY1F@203682|Planctomycetes	203682|Planctomycetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
CMS2_k127_1232708_4	1303518.CCALI_02041	1.013e-06	56.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	4.2.2.5	ko:K19049	-	-	-	-	ko00000,ko01000	-	PL8	-	Cellulase,DUF5060,Lyase_8,Lyase_8_C,Lyase_8_N,RicinB_lectin_2,SLH
CMS2_k127_124322_20	246194.CHY_1764	2.841e-06	50.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,42ER4@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM phosphoesterase, RecJ domain protein	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
CMS2_k127_124322_18	1142394.PSMK_07210	1.085e-08	65.0	COG2165@1|root,COG2165@2|Bacteria,2J0Q6@203682|Planctomycetes	2|Bacteria	U	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_124322_14	411902.CLOBOL_05146	2.216e-24	116.0	2F6FK@1|root,33YYQ@2|Bacteria,1VXUU@1239|Firmicutes,251W9@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_124322_4	398512.JQKC01000027_gene3921	3.326e-87	297.0	COG0641@1|root,COG0641@2|Bacteria,1V5ZZ@1239|Firmicutes,24IY0@186801|Clostridia,3WRPY@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM superfamily	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS2_k127_124322_0	868131.MSWAN_0303	4.661e-221	697.0	COG1232@1|root,arCOG01522@2157|Archaea,2XY37@28890|Euryarchaeota	28890|Euryarchaeota	H	PFAM amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
CMS2_k127_124322_16	644282.Deba_0209	1.594e-10	68.0	COG0454@1|root,COG0456@2|Bacteria,1MYK6@1224|Proteobacteria,42TT3@68525|delta/epsilon subdivisions,2WQGD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
CMS2_k127_124322_11	1121440.AUMA01000010_gene327	1.757e-50	185.0	COG1437@1|root,COG1437@2|Bacteria,1RJYE@1224|Proteobacteria,42ZWS@68525|delta/epsilon subdivisions,2WVBV@28221|Deltaproteobacteria,2MBNM@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	CYTH	-	-	-	-	-	-	-	-	-	-	-	-	CYTH
CMS2_k127_124322_10	215803.DB30_1540	1.074e-54	211.0	COG0642@1|root,COG2205@2|Bacteria,1N5YU@1224|Proteobacteria,42N55@68525|delta/epsilon subdivisions,2WVAY@28221|Deltaproteobacteria,2YWI6@29|Myxococcales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS2_k127_124322_17	672.VV93_v1c10620	6.021e-09	65.0	COG3391@1|root,COG3391@2|Bacteria,1R7T0@1224|Proteobacteria,1RZFR@1236|Gammaproteobacteria,1XWSW@135623|Vibrionales	135623|Vibrionales	M	Domain of unknown function (DUF4842)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4842
CMS2_k127_124322_12	862908.BMS_3108	2.908e-39	157.0	COG0535@1|root,COG0535@2|Bacteria,1Q4MW@1224|Proteobacteria,4347F@68525|delta/epsilon subdivisions,2MUKJ@213481|Bdellovibrionales,2X32C@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
CMS2_k127_124322_3	926569.ANT_25800	3.482e-89	308.0	28KCX@1|root,2Z9ZQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_124322_19	1151117.AJLF01000001_gene1301	1.308e-06	57.0	COG1310@1|root,arCOG01138@2157|Archaea,2Y1J4@28890|Euryarchaeota,244HG@183968|Thermococci	183968|Thermococci	S	JAB/MPN domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
CMS2_k127_124322_8	1265503.KB905162_gene3560	2.929e-68	242.0	COG0652@1|root,COG0652@2|Bacteria,1RBX1@1224|Proteobacteria,1SYJW@1236|Gammaproteobacteria,2Q6RR@267889|Colwelliaceae	1236|Gammaproteobacteria	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
CMS2_k127_124322_6	756272.Plabr_2714	2.251e-79	274.0	COG2755@1|root,COG2755@2|Bacteria,2J37I@203682|Planctomycetes	203682|Planctomycetes	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS2_k127_124322_2	1123242.JH636435_gene1524	4.01e-165	536.0	COG2936@1|root,COG2936@2|Bacteria,2J2G5@203682|Planctomycetes	203682|Planctomycetes	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS2_k127_124322_5	446470.Snas_3533	5.827e-81	278.0	COG0584@1|root,COG0584@2|Bacteria,2GIY5@201174|Actinobacteria	201174|Actinobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	GDPD_2
CMS2_k127_124322_9	517418.Ctha_1404	7.71e-65	231.0	COG1136@1|root,COG1136@2|Bacteria,1FENG@1090|Chlorobi	1090|Chlorobi	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS2_k127_124322_7	1519464.HY22_12335	5.887e-74	266.0	COG4591@1|root,COG4591@2|Bacteria,1FECJ@1090|Chlorobi	1090|Chlorobi	M	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_124322_13	604331.AUHY01000007_gene716	2.041e-38	164.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	algG	-	5.1.3.37	ko:K01795	ko00051,map00051	-	R08693	RC00509	ko00000,ko00001,ko01000	-	-	-	Beta_helix,DUF1565,NosD
CMS2_k127_124322_1	1449050.JNLE01000003_gene65	9.497e-172	557.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E4P@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS2_k127_1256361_2	1051646.VITU9109_14061	2.97e-17	88.0	COG0265@1|root,COG3291@1|root,COG0265@2|Bacteria,COG3291@2|Bacteria,1R6VW@1224|Proteobacteria,1SNEA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1256361_1	398512.JQKC01000029_gene4309	1.89e-39	168.0	2DMC5@1|root,32IWK@2|Bacteria,1VVW4@1239|Firmicutes,2511P@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1256361_3	247490.KSU1_C1333	2.111e-11	77.0	COG4968@1|root,COG4968@2|Bacteria,2J519@203682|Planctomycetes	203682|Planctomycetes	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_1256361_0	391625.PPSIR1_31953	2.916e-77	269.0	COG0810@1|root,COG2304@1|root,COG0810@2|Bacteria,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42NNC@68525|delta/epsilon subdivisions,2WKQW@28221|Deltaproteobacteria,2Z33Y@29|Myxococcales	28221|Deltaproteobacteria	M	Von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
CMS2_k127_125801_11	398512.JQKC01000029_gene4352	5.05e-36	149.0	2DMC5@1|root,32IWK@2|Bacteria,1VVW4@1239|Firmicutes,2511P@186801|Clostridia	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_125801_12	42256.RradSPS_3074	2.991e-35	147.0	COG0265@1|root,COG0265@2|Bacteria,2ICC4@201174|Actinobacteria	201174|Actinobacteria	O	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_125801_13	1237149.C900_00032	1.056e-25	124.0	COG2353@1|root,COG2911@1|root,COG2353@2|Bacteria,COG2911@2|Bacteria,4PMEU@976|Bacteroidetes,47RH2@768503|Cytophagia	976|Bacteroidetes	G	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	BNR_assoc_N,Laminin_G_3
CMS2_k127_125801_15	595536.ADVE02000001_gene1183	5.596e-06	59.0	COG1404@1|root,COG5549@1|root,COG1404@2|Bacteria,COG5549@2|Bacteria,1MU3S@1224|Proteobacteria,2U4GD@28211|Alphaproteobacteria,370TQ@31993|Methylocystaceae	28211|Alphaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Peptidase_S8
CMS2_k127_125801_7	237368.SCABRO_01915	5.362e-79	275.0	COG0673@1|root,COG0673@2|Bacteria,2IXAX@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_125801_10	1196095.GAPWK_2753	6.299e-53	197.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008780,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iPC815.YPO1056	Acetyltransf_11,Hexapep
CMS2_k127_125801_2	1142394.PSMK_05870	1.484e-141	461.0	COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,2IZ4S@203682|Planctomycetes	203682|Planctomycetes	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108,4.2.1.59	ko:K02535,ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	M00060,M00083	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	-	-	-	FabA,LpxC
CMS2_k127_125801_8	497964.CfE428DRAFT_4703	8.669e-65	234.0	COG1044@1|root,COG1044@2|Bacteria,46SAD@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
CMS2_k127_125801_14	1142394.PSMK_07160	2.049e-08	64.0	COG2825@1|root,COG2825@2|Bacteria	2|Bacteria	M	unfolded protein binding	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
CMS2_k127_125801_5	1142394.PSMK_07170	1.491e-92	331.0	COG4775@1|root,COG4775@2|Bacteria,2IWWA@203682|Planctomycetes	203682|Planctomycetes	M	Outer membrane protein assembly complex, YaeT protein	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
CMS2_k127_125801_3	1142394.PSMK_13120	2.826e-134	443.0	COG0305@1|root,COG0305@2|Bacteria,2IXJT@203682|Planctomycetes	203682|Planctomycetes	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
CMS2_k127_125801_0	1047013.AQSP01000130_gene1862	0.0	1052.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2NNS9@2323|unclassified Bacteria	2|Bacteria	EU	peptidase S9 prolyl oligopeptidase active site	ptpA_1	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008239,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042597,GO:0042802,GO:0042803,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044464,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS2_k127_125801_6	1142394.PSMK_10550	3.175e-88	312.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,2IXA1@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP,HATPase_c,HisKA
CMS2_k127_125801_1	439235.Dalk_2756	8.857e-214	686.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2MI7X@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
CMS2_k127_125801_4	1210884.HG799469_gene14163	4.256e-99	340.0	COG0666@1|root,COG1520@1|root,COG0666@2|Bacteria,COG1520@2|Bacteria,2J2A4@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS2_k127_125801_9	1192034.CAP_0376	1.811e-61	221.0	COG1673@1|root,COG1673@2|Bacteria,1R2U4@1224|Proteobacteria	1224|Proteobacteria	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1262131_4	1499967.BAYZ01000068_gene1977	4.271e-87	294.0	COG0217@1|root,COG0217@2|Bacteria,2NNSI@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
CMS2_k127_1262131_5	583355.Caka_0200	4.368e-66	234.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,Kelch_4,Kelch_6
CMS2_k127_1262131_0	886293.Sinac_2253	2.822e-157	512.0	COG1418@1|root,COG1418@2|Bacteria,2IX35@203682|Planctomycetes	203682|Planctomycetes	D	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
CMS2_k127_1262131_3	237368.SCABRO_01255	9.197e-88	300.0	COG1692@1|root,COG1692@2|Bacteria,2IXR1@203682|Planctomycetes	203682|Planctomycetes	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
CMS2_k127_1262131_2	858215.Thexy_1729	2.807e-89	311.0	COG3693@1|root,COG3693@2|Bacteria,1UZWX@1239|Firmicutes,24BPR@186801|Clostridia	186801|Clostridia	G	PFAM glycoside hydrolase, family 10	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_10
CMS2_k127_1262131_6	1125701.HMPREF1221_01616	2.608e-43	176.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1262131_1	1121468.AUBR01000017_gene2367	1.057e-123	415.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,42EUR@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM UvrD REP helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
CMS2_k127_1266779_10	448385.sce1143	2.554e-16	85.0	COG3210@1|root,COG3210@2|Bacteria,1QW1H@1224|Proteobacteria	1224|Proteobacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1266779_2	509191.AEDB02000022_gene2935	4.01e-154	531.0	COG2006@1|root,COG2006@2|Bacteria,1VRZ8@1239|Firmicutes,24Z9V@186801|Clostridia,3WN5G@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Dockerin_1
CMS2_k127_1266779_11	96561.Dole_1875	1.726e-11	79.0	COG3210@1|root,COG3210@2|Bacteria,1QW1H@1224|Proteobacteria	1224|Proteobacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1266779_5	573413.Spirs_1037	4.837e-48	199.0	COG2220@1|root,COG2220@2|Bacteria,2JB81@203691|Spirochaetes	203691|Spirochaetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CMS2_k127_1266779_12	1120949.KB903296_gene9380	1.185e-10	76.0	COG2755@1|root,COG3209@1|root,COG3291@1|root,COG2755@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,2GMBB@201174|Actinobacteria,4DBAV@85008|Micromonosporales	201174|Actinobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PT-HINT,RHS_repeat,Ricin_B_lectin,VCBS
CMS2_k127_1266779_7	439235.Dalk_2500	6.957e-24	120.0	COG2931@1|root,COG2931@2|Bacteria,1QVQT@1224|Proteobacteria	1224|Proteobacteria	Q	Clostripain family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C11
CMS2_k127_1266779_9	439235.Dalk_2502	5.996e-17	97.0	COG1716@1|root,COG1716@2|Bacteria,1RBAY@1224|Proteobacteria,42UEV@68525|delta/epsilon subdivisions,2X7ZJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	peptidase C11	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C11
CMS2_k127_1266779_4	497965.Cyan7822_0583	9.812e-54	218.0	COG2931@1|root,COG3210@1|root,COG5492@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG5492@2|Bacteria,1GC1J@1117|Cyanobacteria,3KJVM@43988|Cyanothece	1117|Cyanobacteria	QU	Polymorphic membrane protein Chlamydia	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin
CMS2_k127_1266779_0	56780.SYN_02854	1.815e-272	867.0	COG0297@1|root,COG1449@1|root,COG0297@2|Bacteria,COG1449@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	-	-	2.4.1.21,3.2.1.1	ko:K00703,ko:K01176	ko00500,ko01100,ko01110,ko02026,ko04973,map00500,map01100,map01110,map02026,map04973	M00565	R02108,R02112,R02421,R11262	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GH13,GT5	-	Glyco_trans_1_4,Glyco_transf_5,Glycos_transf_1
CMS2_k127_1266779_6	886293.Sinac_7067	1.927e-32	133.0	COG0824@1|root,COG0824@2|Bacteria,2J0BH@203682|Planctomycetes	203682|Planctomycetes	S	thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
CMS2_k127_1266779_1	1124780.ANNU01000077_gene789	3.473e-160	518.0	COG0477@1|root,COG0477@2|Bacteria,4PKTJ@976|Bacteroidetes,47YD9@768503|Cytophagia	976|Bacteroidetes	EGP	Sugar (and other) transporter	-	-	-	ko:K08138	-	-	-	-	ko00000,ko02000	2.A.1.1.3	-	-	Sugar_tr
CMS2_k127_1266779_3	388413.ALPR1_09705	3.589e-153	507.0	COG3119@1|root,COG3119@2|Bacteria,4NEZJ@976|Bacteroidetes	976|Bacteroidetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,Sulfatase
CMS2_k127_1266779_8	1267533.KB906739_gene2717	1.316e-22	104.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid_C,Bgal_small_N,Glyco_hydro_2,Glyco_hydro_28,Glyco_hydro_2_C,Glyco_hydro_2_N,fn3
CMS2_k127_1267962_2	1123508.JH636456_gene145	4.576e-178	563.0	COG0282@1|root,COG0282@2|Bacteria,2IXZC@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	-	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
CMS2_k127_1267962_6	105559.Nwat_0421	8.159e-78	267.0	COG0637@1|root,COG0637@2|Bacteria	2|Bacteria	S	phosphonoacetaldehyde hydrolase activity	-	-	2.6.1.9,3.1.3.10	ko:K00817,ko:K07025,ko:K20866	ko00010,ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01120,ko01130,ko01230,map00010,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01120,map01130,map01230	M00026	R00694,R00734,R00947,R03243	RC00006,RC00078,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	HAD_2,Hydrolase
CMS2_k127_1267962_3	1159870.KB907784_gene2897	1.887e-150	486.0	COG1994@1|root,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria	1224|Proteobacteria	K	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
CMS2_k127_1267962_0	1163617.SCD_n00706	0.0	1471.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria	28216|Betaproteobacteria	G	alpha-glucan phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
CMS2_k127_1267962_1	1123508.JH636456_gene143	1.656e-276	861.0	COG0033@1|root,COG0033@2|Bacteria,2IYG0@203682|Planctomycetes	203682|Planctomycetes	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS2_k127_1267962_4	706587.Desti_2109	4.784e-147	476.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2WIXQ@28221|Deltaproteobacteria,2MRG0@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the GPI family	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
CMS2_k127_1267962_5	1408473.JHXO01000008_gene2655	6.349e-126	408.0	COG0330@1|root,COG0330@2|Bacteria,4NH8V@976|Bacteroidetes,2FQPC@200643|Bacteroidia	976|Bacteroidetes	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS2_k127_1267962_7	646529.Desaci_0664	5.43e-77	261.0	COG4803@1|root,COG4803@2|Bacteria,1UJ40@1239|Firmicutes,24JIS@186801|Clostridia	186801|Clostridia	S	membrane protein of uknown function UCP014873	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269,YflT
CMS2_k127_1267962_8	667014.Thein_0120	2.753e-27	117.0	COG0071@1|root,COG0071@2|Bacteria,2GHTW@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS2_k127_1267962_11	1382359.JIAL01000001_gene2996	2.591e-05	50.0	2EFSR@1|root,339IR@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
CMS2_k127_1267962_10	756272.Plabr_3512	4.795e-06	54.0	COG1366@1|root,COG1366@2|Bacteria,2J02R@203682|Planctomycetes	203682|Planctomycetes	T	Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS2_k127_1287252_0	1303518.CCALI_00184	1.114e-182	597.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	galA	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_4_9,CBM_6,DUF1565
CMS2_k127_1287252_1	1123322.KB904702_gene181	1.455e-18	94.0	COG1874@1|root,COG1874@2|Bacteria,2IAS8@201174|Actinobacteria	201174|Actinobacteria	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1289774_0	472759.Nhal_2490	9.411e-112	369.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1WX35@135613|Chromatiales	135613|Chromatiales	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
CMS2_k127_1289774_5	530564.Psta_1965	7.645e-13	75.0	COG2165@1|root,COG2165@2|Bacteria,2J10X@203682|Planctomycetes	203682|Planctomycetes	U	Pfam:N_methyl_2	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_1289774_2	886293.Sinac_6422	5.785e-80	293.0	COG0421@1|root,COG4262@1|root,COG0421@2|Bacteria,COG4262@2|Bacteria,2IYZX@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
CMS2_k127_1289774_4	278957.ABEA03000069_gene3974	4.5e-15	87.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_1289774_3	247490.KSU1_C0166	8.373e-64	236.0	COG0772@1|root,COG0772@2|Bacteria,2IZRI@203682|Planctomycetes	203682|Planctomycetes	D	Belongs to the SEDS family	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
CMS2_k127_1289774_1	237368.SCABRO_01931	1.724e-83	299.0	COG0728@1|root,COG0728@2|Bacteria,2IYP2@203682|Planctomycetes	203682|Planctomycetes	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
CMS2_k127_1294368_0	316067.Geob_2677	3.745e-156	503.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,43U14@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
CMS2_k127_1294368_11	237368.SCABRO_03511	3.679e-19	96.0	COG0558@1|root,COG0558@2|Bacteria,2J36U@203682|Planctomycetes	203682|Planctomycetes	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
CMS2_k127_1294368_9	232348.ADXL01000093_gene355	1.602e-23	115.0	COG1459@1|root,COG1459@2|Bacteria,1G164@1117|Cyanobacteria,1GYBJ@1129|Synechococcus	1117|Cyanobacteria	U	Type II secretory pathway, component PulF	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
CMS2_k127_1294368_4	760568.Desku_1007	4.04e-38	147.0	COG2164@1|root,COG2164@2|Bacteria,1VHU9@1239|Firmicutes,24TQA@186801|Clostridia	186801|Clostridia	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
CMS2_k127_1294368_3	1123242.JH636435_gene3009	4.405e-76	262.0	COG0854@1|root,COG0854@2|Bacteria,2IYJ4@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
CMS2_k127_1294368_2	344747.PM8797T_29198	4.866e-109	360.0	COG0329@1|root,COG0329@2|Bacteria,2IXII@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CMS2_k127_1294368_12	3847.GLYMA08G22900.3	3.92e-18	99.0	KOG1947@1|root,KOG1947@2759|Eukaryota,37ICC@33090|Viridiplantae,3G9ZF@35493|Streptophyta,4JFG9@91835|fabids	35493|Streptophyta	S	F-box LRR-repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LRR_5,LRR_6,LRR_8
CMS2_k127_1294368_5	264201.pc1565	1.726e-34	152.0	COG4886@1|root,COG4886@2|Bacteria,2JGIV@204428|Chlamydiae	204428|Chlamydiae	S	Leucine Rich repeat	-	-	-	-	-	-	-	-	-	-	-	-	BTB,LRR_1,LRR_6
CMS2_k127_1294368_7	1396141.BATP01000060_gene4596	1.022e-24	117.0	COG1595@1|root,COG1595@2|Bacteria,46TQ4@74201|Verrucomicrobia,2IVUY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_1294368_8	521674.Plim_4196	6.296e-24	115.0	COG0438@1|root,COG0438@2|Bacteria,2J24T@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_1294368_10	1121479.AUBS01000004_gene2364	1.907e-22	101.0	COG0071@1|root,COG0071@2|Bacteria,1NA27@1224|Proteobacteria,2UGVG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
CMS2_k127_1294368_6	1123371.ATXH01000012_gene1452	2.878e-26	113.0	COG0071@1|root,COG0071@2|Bacteria,2GI9N@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS2_k127_1294368_1	1297742.A176_02604	2.332e-136	467.0	COG1404@1|root,COG3227@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3227@2|Bacteria,COG3291@2|Bacteria,1RFYD@1224|Proteobacteria,439R3@68525|delta/epsilon subdivisions,2X53R@28221|Deltaproteobacteria,2Z02M@29|Myxococcales	28221|Deltaproteobacteria	O	Bacterial pre-peptidase C-terminal domain	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PPC
CMS2_k127_1299634_6	237368.SCABRO_00764	3.224e-53	197.0	COG1971@1|root,COG1971@2|Bacteria	2|Bacteria	P	manganese ion transmembrane transporter activity	mntP	-	-	-	-	-	-	-	-	-	-	-	Mntp
CMS2_k127_1299634_9	1243664.CAVL020000025_gene1638	1.615e-39	160.0	COG1408@1|root,COG1408@2|Bacteria,1UU17@1239|Firmicutes,4HC8Q@91061|Bacilli,1ZB99@1386|Bacillus	91061|Bacilli	S	Metallophosphoesterase	ykuE	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
CMS2_k127_1299634_5	1195236.CTER_0563	4.69e-66	233.0	COG0145@1|root,COG0145@2|Bacteria,1V3GN@1239|Firmicutes,25DNJ@186801|Clostridia,3WPEF@541000|Ruminococcaceae	186801|Clostridia	EQ	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
CMS2_k127_1299634_3	697281.Mahau_2253	3.316e-89	304.0	COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24FCZ@186801|Clostridia,42HY1@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
CMS2_k127_1299634_11	760568.Desku_0882	4.902e-10	69.0	COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,2617G@186807|Peptococcaceae	186801|Clostridia	S	PFAM Metallo-beta-lactamase superfamily	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Ada_Zn_binding,LTD,Lactamase_B
CMS2_k127_1299634_1	344747.PM8797T_11259	6.495e-115	381.0	COG1082@1|root,COG1082@2|Bacteria,2IY3R@203682|Planctomycetes	203682|Planctomycetes	G	ioli protein	-	-	5.3.99.11	ko:K06606	ko00562,ko01120,map00562,map01120	-	R09952	RC01513	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
CMS2_k127_1299634_14	983545.Glaag_2611	1.962e-05	51.0	COG3377@1|root,COG3377@2|Bacteria,1NDRD@1224|Proteobacteria,1SP82@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1805)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1805
CMS2_k127_1299634_0	247490.KSU1_B0387	4.534e-133	441.0	COG1109@1|root,COG1109@2|Bacteria,2IXRS@203682|Planctomycetes	203682|Planctomycetes	G	PFAM Phosphoglucomutase phosphomannomutase, alpha beta alpha domain	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS2_k127_1299634_8	1382306.JNIM01000001_gene1745	2.255e-45	186.0	COG0249@1|root,COG0249@2|Bacteria,2G8CJ@200795|Chloroflexi	200795|Chloroflexi	L	PFAM DNA mismatch repair protein MutS domain protein	-	-	-	-	-	-	-	-	-	-	-	-	MutS_V
CMS2_k127_1299634_15	745014.OMB55_00014540	0.0001991	54.0	COG2706@1|root,COG2706@2|Bacteria,1QV84@1224|Proteobacteria	1224|Proteobacteria	G	PFAM Ig family protein	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Lactonase,VCBS
CMS2_k127_1299634_13	1144319.PMI16_01881	1.583e-07	64.0	COG3209@1|root,COG3209@2|Bacteria,1R1SB@1224|Proteobacteria,2W3D6@28216|Betaproteobacteria	1224|Proteobacteria	M	Salmonella virulence plasmid 65kDa B protein	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS2_k127_1299634_4	1122921.KB898193_gene2576	9.104e-69	247.0	COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,4HBGH@91061|Bacilli,26QWM@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter, ATP-binding protein	bcrA3	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_1299634_12	621372.ACIH01000200_gene1627	1.154e-08	66.0	COG1277@1|root,COG1277@2|Bacteria,1TT9E@1239|Firmicutes,4HJPV@91061|Bacilli,26T22@186822|Paenibacillaceae	91061|Bacilli	S	ABC-type transport system involved in multi-copper enzyme maturation, permease component	bcrB3	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
CMS2_k127_1299634_10	96561.Dole_1189	2.178e-29	127.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WNPT@28221|Deltaproteobacteria,2MIZH@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CMS2_k127_1299634_2	331678.Cphamn1_0112	9.258e-95	317.0	COG4106@1|root,COG4106@2|Bacteria	2|Bacteria	FG	trans-aconitate 2-methyltransferase activity	-	-	2.1.1.144,2.1.1.197	ko:K00598,ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
CMS2_k127_1299634_7	644282.Deba_1697	4.728e-47	178.0	COG0500@1|root,COG2226@2|Bacteria,1N3WC@1224|Proteobacteria,42URQ@68525|delta/epsilon subdivisions,2WQGW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
CMS2_k127_1323797_2	661478.OP10G_4315	1.811e-55	204.0	COG4124@1|root,COG4124@2|Bacteria	661478.OP10G_4315|-	G	Belongs to the glycosyl hydrolase 26 family	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	-
CMS2_k127_1323797_0	1047013.AQSP01000075_gene1424	0.0	1451.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2NQEH@2323|unclassified Bacteria	2|Bacteria	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
CMS2_k127_1323797_1	457421.CBFG_01460	1.111e-103	355.0	COG3119@1|root,COG3119@2|Bacteria,1TQEP@1239|Firmicutes,2482B@186801|Clostridia	186801|Clostridia	P	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_1323797_3	546266.NEIMUCOT_06188	7.023e-19	86.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2VIZ7@28216|Betaproteobacteria,2KQ45@206351|Neisseriales	206351|Neisseriales	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS2_k127_132604_4	869213.JCM21142_72658	2.103e-109	363.0	COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,47NH0@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_132604_3	869213.JCM21142_72658	3.53e-135	443.0	COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,47NH0@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_132604_2	1185876.BN8_04770	3.158e-139	454.0	COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,47K7H@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_132604_1	240016.ABIZ01000001_gene3841	3.558e-159	514.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_132604_0	382464.ABSI01000013_gene1815	3.256e-165	526.0	COG1082@1|root,COG1082@2|Bacteria,46UEJ@74201|Verrucomicrobia,2IU34@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
CMS2_k127_132604_8	452637.Oter_2972	5.835e-09	61.0	COG3669@1|root,COG3669@2|Bacteria,46Y1K@74201|Verrucomicrobia,3K8SP@414999|Opitutae	414999|Opitutae	G	PFAM glycoside hydrolase family 29	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
CMS2_k127_132604_7	211165.AJLN01000097_gene5095	2.722e-41	166.0	2EZK8@1|root,33SRA@2|Bacteria,1GD3X@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_132604_6	457429.ABJI02000018_gene1102	7.147e-57	216.0	COG2133@1|root,COG2133@2|Bacteria,2GRVP@201174|Actinobacteria	201174|Actinobacteria	G	PA14	-	-	-	-	-	-	-	-	-	-	-	-	CBM_35,DUF1080,PA14
CMS2_k127_132604_5	1158294.JOMI01000002_gene2994	1.162e-76	275.0	COG3828@1|root,COG3828@2|Bacteria,4NEWH@976|Bacteroidetes,2FQY6@200643|Bacteroidia	976|Bacteroidetes	S	Methane oxygenase PmoA	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
CMS2_k127_133123_0	344747.PM8797T_03419	2.597e-147	480.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS2_k127_133123_5	1305737.JAFX01000001_gene2288	1.475e-06	55.0	COG3682@1|root,COG3682@2|Bacteria,4NSQR@976|Bacteroidetes,47R7N@768503|Cytophagia	976|Bacteroidetes	K	PFAM Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS2_k127_133123_3	1123508.JH636448_gene7569	4.566e-16	94.0	COG4219@1|root,COG4219@2|Bacteria,2J24Z@203682|Planctomycetes	203682|Planctomycetes	KT	Antirepressor regulating drug resistance	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
CMS2_k127_133123_2	163164.WD_0291	6.673e-17	97.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria	1224|Proteobacteria	KT	ankyrin repeat	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_4
CMS2_k127_133123_1	7668.SPU_000234-tr	2.83e-77	297.0	COG0666@1|root,KOG4177@2759|Eukaryota,39NDZ@33154|Opisthokonta	33154|Opisthokonta	M	Ankyrin repeat	-	-	-	ko:K10380,ko:K15502,ko:K19626	ko04310,ko04624,ko05205,map04310,map04624,map05205	-	-	-	ko00000,ko00001,ko01009,ko03400,ko04812	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5
CMS2_k127_133123_4	886293.Sinac_4705	2.203e-07	61.0	COG2834@1|root,COG2834@2|Bacteria,2J4MG@203682|Planctomycetes	203682|Planctomycetes	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1366041_2	203275.BFO_2640	2.186e-11	78.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
CMS2_k127_1366041_1	1047013.AQSP01000125_gene2637	1.421e-99	359.0	COG0823@1|root,COG4946@1|root,COG0823@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Amidohydro_1,PD40,PG_binding_1,Pkinase,TolB_N
CMS2_k127_1366041_0	1499967.BAYZ01000076_gene753	3.447e-123	400.0	COG0412@1|root,COG0412@2|Bacteria,2NPZG@2323|unclassified Bacteria	2|Bacteria	Q	Dienelactone hydrolase family	dlhH	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
CMS2_k127_1381297_2	926550.CLDAP_19500	7.875e-149	533.0	COG0584@1|root,COG0823@1|root,COG3210@1|root,COG4886@1|root,COG0584@2|Bacteria,COG0823@2|Bacteria,COG3210@2|Bacteria,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	3.1.4.46	ko:K01126,ko:K21449	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000,ko02000	1.B.40.2	-	-	GDPD_2
CMS2_k127_1381297_3	760192.Halhy_5387	1.306e-139	503.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	-
CMS2_k127_1381297_7	118173.KB235914_gene625	4.096e-88	320.0	COG4677@1|root,COG4677@2|Bacteria	2|Bacteria	G	pectinesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Lipase_GDSL_2,NosD,Pectate_lyase_3
CMS2_k127_1381297_4	1396418.BATQ01000001_gene1240	7.403e-121	406.0	COG0673@1|root,COG0673@2|Bacteria,46U0A@74201|Verrucomicrobia,2IWJK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_1381297_8	1123242.JH636434_gene5127	5.174e-88	301.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_NS,NHL
CMS2_k127_1381297_0	215803.DB30_4063	1.434e-233	734.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,42PGV@68525|delta/epsilon subdivisions,2WIS0@28221|Deltaproteobacteria,2YZVC@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
CMS2_k127_1381297_10	345341.KUTG_09261	8.838e-59	228.0	COG3250@1|root,COG3250@2|Bacteria,2I9Q2@201174|Actinobacteria,4EAA4@85010|Pseudonocardiales	201174|Actinobacteria	G	Ricin-type beta-trefoil lectin domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,RicinB_lectin_2
CMS2_k127_1381297_1	595460.RRSWK_00052	2.457e-164	531.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_6,F5_F8_type_C,Glyco_hydro_28
CMS2_k127_1381297_6	1082933.MEA186_11056	4.588e-92	316.0	COG1957@1|root,COG1957@2|Bacteria	2|Bacteria	F	ribosylpyrimidine nucleosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
CMS2_k127_1381297_9	1340493.JNIF01000004_gene359	2.831e-74	269.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	Z012_03425	-	3.1.6.14	ko:K01137,ko:K01138	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078,M00079	R07808,R07819	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4976,Sulfatase
CMS2_k127_1381297_11	1095769.CAHF01000006_gene1854	7.189e-14	87.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,2VHHM@28216|Betaproteobacteria,478DK@75682|Oxalobacteraceae	28216|Betaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS2_k127_1381297_5	497964.CfE428DRAFT_2851	1.502e-106	363.0	2F7XU@1|root,340BQ@2|Bacteria,46VS8@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1433200_7	65393.PCC7424_2215	2.867e-13	83.0	COG3591@1|root,COG5276@1|root,COG3591@2|Bacteria,COG5276@2|Bacteria,1G8I7@1117|Cyanobacteria	1117|Cyanobacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin,Trypsin_2
CMS2_k127_1433200_10	1232410.KI421421_gene3471	4.044e-06	55.0	COG3047@1|root,COG3047@2|Bacteria,1RKZG@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OprF
CMS2_k127_1433200_11	926560.KE387023_gene3676	4.706e-06	51.0	COG2010@1|root,COG2010@2|Bacteria,1WN3Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
CMS2_k127_1433200_0	945713.IALB_2579	4.584e-257	813.0	COG1472@1|root,COG1472@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 3 family	bglX	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0008422,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
CMS2_k127_1433200_3	316067.Geob_3252	5.22e-73	251.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,42PP3@68525|delta/epsilon subdivisions,2WK0G@28221|Deltaproteobacteria,43SJH@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
CMS2_k127_1433200_6	1499967.BAYZ01000155_gene632	1.724e-22	103.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	-	-	-	-	-	-	-	-	-	-	-	-	DUF2169,DnaJ,Pentapeptide
CMS2_k127_1433200_9	1121451.DESAM_20371	3.662e-09	60.0	COG2331@1|root,COG2331@2|Bacteria,1P9S7@1224|Proteobacteria,433GA@68525|delta/epsilon subdivisions,2WXCG@28221|Deltaproteobacteria,2MDZ0@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
CMS2_k127_1433200_5	1232437.KL662036_gene2708	4.422e-32	128.0	COG0748@1|root,COG0748@2|Bacteria,1N2JV@1224|Proteobacteria,42TYW@68525|delta/epsilon subdivisions,2WQEM@28221|Deltaproteobacteria,2MK6D@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS2_k127_1433200_2	644966.Tmar_1443	2.388e-84	293.0	COG1090@1|root,COG1090@2|Bacteria,1TRCE@1239|Firmicutes,24GWH@186801|Clostridia	186801|Clostridia	S	PFAM NAD dependent epimerase dehydratase family	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
CMS2_k127_1433200_1	56780.SYN_00402	3.936e-174	558.0	COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria,42NWP@68525|delta/epsilon subdivisions,2WJUA@28221|Deltaproteobacteria,2MQYG@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
CMS2_k127_1433200_4	96561.Dole_1791	1.862e-37	163.0	COG1044@1|root,COG1361@1|root,COG1653@1|root,COG1044@2|Bacteria,COG1361@2|Bacteria,COG1653@2|Bacteria,1N4S6@1224|Proteobacteria,43BRE@68525|delta/epsilon subdivisions,2X729@28221|Deltaproteobacteria,2MNRP@213118|Desulfobacterales	1224|Proteobacteria	G	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1433200_8	111780.Sta7437_1943	1.77e-10	75.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1735,HemolysinCabind,Laminin_G_3
CMS2_k127_1443258_4	1347086.CCBA010000009_gene1371	9.081e-06	50.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4H9VR@91061|Bacilli,1ZB1D@1386|Bacillus	91061|Bacilli	E	Acetolactate synthase	ilvB	-	2.2.1.6	ko:K01652,ko:K16787	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	M00019,M00570,M00582	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS2_k127_1443258_0	237368.SCABRO_03824	2.213e-218	691.0	COG0028@1|root,COG0028@2|Bacteria,2IXMU@203682|Planctomycetes	203682|Planctomycetes	H	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS2_k127_1443258_2	886293.Sinac_4979	1.285e-56	203.0	COG0440@1|root,COG0440@2|Bacteria,2IZ6Q@203682|Planctomycetes	203682|Planctomycetes	E	Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
CMS2_k127_1443258_7	794903.OPIT5_13470	0.0007427	42.0	2AII5@1|root,31903@2|Bacteria,46YKX@74201|Verrucomicrobia,3K9T5@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1443258_3	1123053.AUDG01000057_gene3267	3.47e-08	58.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1WWU7@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
CMS2_k127_1443258_1	794903.OPIT5_30520	4.68e-57	209.0	COG0012@1|root,COG0012@2|Bacteria,46UY8@74201|Verrucomicrobia	74201|Verrucomicrobia	J	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1443303_0	794903.OPIT5_30520	9.195e-52	194.0	COG0012@1|root,COG0012@2|Bacteria,46UY8@74201|Verrucomicrobia	74201|Verrucomicrobia	J	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1443303_2	192952.MM_2804	5.404e-12	79.0	arCOG03499@1|root,arCOG03499@2157|Archaea	2157|Archaea	G	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Disaggr_assoc,Disaggr_repeat,PKD
CMS2_k127_1443303_5	457570.Nther_2618	3.875e-08	66.0	COG0705@1|root,COG3420@1|root,COG0705@2|Bacteria,COG3420@2|Bacteria,1VXV8@1239|Firmicutes,25EQ2@186801|Clostridia	186801|Clostridia	P	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1443303_1	118168.MC7420_6956	1.033e-24	121.0	COG4886@1|root,COG4886@2|Bacteria,1G4SR@1117|Cyanobacteria,1HAQW@1150|Oscillatoriales	1117|Cyanobacteria	G	Leucine-rich repeat	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	LRR_4,LRR_6,LRR_8
CMS2_k127_1443303_3	661478.OP10G_2054	3.713e-10	72.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02650,ko:K02679	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	N_methyl,SBP_bac_10
CMS2_k127_1443303_4	290315.Clim_1363	1.513e-09	59.0	COG4826@1|root,COG4826@2|Bacteria	2|Bacteria	O	serine-type endopeptidase inhibitor activity	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
CMS2_k127_1491371_3	1044.EH31_13780	9.555e-11	73.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1MX3A@1224|Proteobacteria,2TUU6@28211|Alphaproteobacteria,2K0I3@204457|Sphingomonadales	204457|Sphingomonadales	QU	Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
CMS2_k127_1491371_4	1341181.FLJC2902T_25080	3.783e-08	65.0	COG0823@1|root,COG0823@2|Bacteria,4NG4S@976|Bacteroidetes,1I1I2@117743|Flavobacteriia	976|Bacteroidetes	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
CMS2_k127_1491371_0	1047013.AQSP01000144_gene927	5.421e-285	897.0	COG3533@1|root,COG3533@2|Bacteria,2NNW0@2323|unclassified Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	F5_F8_type_C,Glyco_hydro_127
CMS2_k127_1491371_1	502025.Hoch_2275	1.095e-36	145.0	arCOG10116@1|root,315E2@2|Bacteria,1MYJ7@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1491371_2	502025.Hoch_2274	8.448e-12	66.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2WWD4@28221|Deltaproteobacteria,2YTYG@29|Myxococcales	28221|Deltaproteobacteria	S	oligopeptide transporter, OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
CMS2_k127_149516_5	1284775.HMPREF1640_12400	3.82e-07	52.0	COG0336@1|root,COG0336@2|Bacteria,4NF2Q@976|Bacteroidetes,2FPQ5@200643|Bacteroidia	976|Bacteroidetes	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
CMS2_k127_149516_2	926569.ANT_00870	5.589e-93	320.0	COG0457@1|root,COG0457@2|Bacteria,2G94P@200795|Chloroflexi	200795|Chloroflexi	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2
CMS2_k127_149516_1	926569.ANT_00860	2.394e-108	369.0	COG0457@1|root,COG0457@2|Bacteria,2G94P@200795|Chloroflexi	200795|Chloroflexi	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2
CMS2_k127_149516_3	926569.ANT_26660	3.421e-40	150.0	COG0234@1|root,COG0234@2|Bacteria,2G6WW@200795|Chloroflexi	200795|Chloroflexi	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
CMS2_k127_149516_0	926569.ANT_26670	8.957e-257	800.0	COG0459@1|root,COG0459@2|Bacteria,2G65N@200795|Chloroflexi	200795|Chloroflexi	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS2_k127_149516_4	1128421.JAGA01000003_gene2785	1.067e-22	103.0	COG0472@1|root,COG0472@2|Bacteria,2NR03@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	CoA_binding_3,Glycos_transf_4
CMS2_k127_1495497_8	595536.ADVE02000001_gene1399	1.263e-08	64.0	COG1596@1|root,COG1596@2|Bacteria,1RE48@1224|Proteobacteria,2U75D@28211|Alphaproteobacteria,3705A@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Polysaccharide biosynthesis/export protein	gumB	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
CMS2_k127_1495497_7	1122915.AUGY01000075_gene3132	1.07e-08	62.0	COG3401@1|root,COG3664@1|root,COG3401@2|Bacteria,COG3664@2|Bacteria,1VTGP@1239|Firmicutes,4HV8E@91061|Bacilli,26VFN@186822|Paenibacillaceae	91061|Bacilli	G	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1,Glyco_hydro_cc
CMS2_k127_1495497_2	1123508.JH636439_gene1628	1.787e-130	428.0	COG0673@1|root,COG0673@2|Bacteria,2IX0C@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_1495497_4	1396418.BATQ01000047_gene6218	5.994e-125	411.0	COG2382@1|root,COG2382@2|Bacteria,46UH3@74201|Verrucomicrobia,2IUBH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_48,Esterase
CMS2_k127_1495497_3	886293.Sinac_4418	1.464e-125	422.0	COG5434@1|root,COG5434@2|Bacteria,2J4KC@203682|Planctomycetes	203682|Planctomycetes	M	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1495497_0	697281.Mahau_2064	2.688e-195	631.0	COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia,42FYE@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Glycoside hydrolase family 42 domain protein	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
CMS2_k127_1495497_1	497964.CfE428DRAFT_4082	5.369e-158	509.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF3472,DUF5077,Gram_pos_anchor,Reprolysin_4
CMS2_k127_1495497_10	7739.XP_002595429.1	7.178e-05	55.0	2BX6I@1|root,2SDQT@2759|Eukaryota	7739.XP_002595429.1|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1495497_9	344747.PM8797T_00397	2.923e-07	64.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,DUF4129,Transglut_core
CMS2_k127_1495497_5	243090.RB2092	6.21e-86	291.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
CMS2_k127_1495497_6	1210884.HG799462_gene8420	5.902e-30	124.0	COG1073@1|root,COG1073@2|Bacteria,2IWSQ@203682|Planctomycetes	203682|Planctomycetes	S	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
CMS2_k127_1530365_0	1121335.Clst_1060	1.174e-100	347.0	COG1283@1|root,COG1283@2|Bacteria,1TP4K@1239|Firmicutes,247KT@186801|Clostridia,3WNBR@541000|Ruminococcaceae	186801|Clostridia	P	Na+/Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
CMS2_k127_1530365_1	1232410.KI421421_gene3405	1.028e-87	295.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,43S7H@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_1530365_3	1289135.A966_01140	5.704e-58	208.0	COG2344@1|root,COG2344@2|Bacteria,2J89C@203691|Spirochaetes	203691|Spirochaetes	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
CMS2_k127_1530365_2	1125863.JAFN01000001_gene457	1.615e-78	275.0	COG1624@1|root,COG1624@2|Bacteria,1N12B@1224|Proteobacteria,42UVR@68525|delta/epsilon subdivisions,2WQ2R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Diadenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DisA_N
CMS2_k127_1530365_4	1197130.BAFM01000006_gene1264	1.881e-48	180.0	COG3476@1|root,arCOG04434@2157|Archaea,2XYQD@28890|Euryarchaeota,23X42@183963|Halobacteria	183963|Halobacteria	T	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
CMS2_k127_1530365_5	177439.DP1864	4.977e-30	126.0	COG1633@1|root,COG1633@2|Bacteria,1RM4Q@1224|Proteobacteria,42SRM@68525|delta/epsilon subdivisions,2WP47@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_1530365_6	1122609.AUGT01000008_gene2868	4.317e-15	85.0	COG0366@1|root,COG0515@1|root,COG2133@1|root,COG3227@1|root,COG4733@1|root,COG0366@2|Bacteria,COG0515@2|Bacteria,COG2133@2|Bacteria,COG3227@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.3	ko:K01178,ko:K14645,ko:K18546	ko00500,ko01100,ko02024,map00500,map01100,map02024	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH15	-	Alpha-amylase,GSDH,He_PIG,PKD,Pro_Al_protease,SLH,Trypsin,fn3
CMS2_k127_1575497_4	269799.Gmet_0216	1.183e-08	61.0	COG1708@1|root,COG1708@2|Bacteria,1NJVS@1224|Proteobacteria,42XFN@68525|delta/epsilon subdivisions,2WT5N@28221|Deltaproteobacteria,43VVY@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM DNA polymerase, beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CMS2_k127_1575497_2	289376.THEYE_A1691	2.977e-43	160.0	COG2250@1|root,COG2250@2|Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_1575497_0	583355.Caka_0956	5.819e-100	343.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C,TAT_signal
CMS2_k127_1575497_3	929562.Emtol_1177	5.642e-38	147.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,47JNX@768503|Cytophagia	976|Bacteroidetes	S	PFAM Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_158351_3	1122973.KB904281_gene1068	1.252e-26	115.0	COG2304@1|root,COG2304@2|Bacteria,4NDUC@976|Bacteroidetes,2FNXM@200643|Bacteroidia,22XC0@171551|Porphyromonadaceae	976|Bacteroidetes	S	Von Willebrand factor type A domain	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
CMS2_k127_158351_0	1123242.JH636434_gene5411	1.082e-59	219.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,2IYZ1@203682|Planctomycetes	203682|Planctomycetes	A	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
CMS2_k127_158351_4	344747.PM8797T_13987	3.704e-15	87.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,2IYZ1@203682|Planctomycetes	203682|Planctomycetes	A	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
CMS2_k127_158351_1	1499967.BAYZ01000152_gene1397	4.892e-44	185.0	COG0457@1|root,COG0457@2|Bacteria,2NP5J@2323|unclassified Bacteria	2|Bacteria	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
CMS2_k127_158351_2	886293.Sinac_5446	1.231e-36	143.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_1591100_12	485917.Phep_2792	1.107e-07	65.0	COG3866@1|root,COG3866@2|Bacteria,4NJUK@976|Bacteroidetes	976|Bacteroidetes	G	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1591100_8	1168034.FH5T_08475	1.142e-32	147.0	COG2133@1|root,COG2911@1|root,COG3227@1|root,COG2133@2|Bacteria,COG2911@2|Bacteria,COG3227@2|Bacteria	2|Bacteria	E	Zinc metalloprotease (Elastase)	-	-	-	-	-	-	-	-	-	-	-	-	MAM,PATR,Peptidase_M43,fn3
CMS2_k127_1591100_11	1453505.JASY01000003_gene2149	2.108e-08	68.0	COG3866@1|root,COG3866@2|Bacteria,4NJUK@976|Bacteroidetes,1IIIB@117743|Flavobacteriia,2NUS2@237|Flavobacterium	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1591100_3	56780.SYN_02872	1.13e-60	237.0	COG0685@1|root,COG0685@2|Bacteria,1NB3G@1224|Proteobacteria,42P1W@68525|delta/epsilon subdivisions,2WKDD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Methylene-tetrahydrofolate reductase C terminal	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,MTHFR_C
CMS2_k127_1591100_10	768710.DesyoDRAFT_3380	6.369e-10	73.0	COG1410@1|root,COG1410@2|Bacteria,1V0F4@1239|Firmicutes,25CEI@186801|Clostridia,260JU@186807|Peptococcaceae	186801|Clostridia	E	PFAM Pterin binding enzyme	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CMS2_k127_1591100_0	926561.KB900617_gene1806	3.065e-146	479.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,3WB17@53433|Halanaerobiales	186801|Clostridia	P	PFAM Cation	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS2_k127_1591100_4	926692.AZYG01000007_gene1238	7.242e-60	214.0	COG0569@1|root,COG0569@2|Bacteria,1UD9U@1239|Firmicutes,25HY7@186801|Clostridia,3WBIC@53433|Halanaerobiales	186801|Clostridia	P	PFAM TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS2_k127_1591100_9	880073.Calab_0082	1.427e-31	132.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_1591100_5	1036674.A28LD_1047	1.842e-38	145.0	COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1S62I@1236|Gammaproteobacteria,2QGXP@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
CMS2_k127_1591100_6	439235.Dalk_3751	1.429e-34	137.0	COG1585@1|root,COG1585@2|Bacteria,1PJH9@1224|Proteobacteria,42WNG@68525|delta/epsilon subdivisions,2WRM8@28221|Deltaproteobacteria,2MKU2@213118|Desulfobacterales	28221|Deltaproteobacteria	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
CMS2_k127_1591100_1	439235.Dalk_3750	3.5e-137	443.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WKYT@28221|Deltaproteobacteria,2MHN9@213118|Desulfobacterales	28221|Deltaproteobacteria	O	C-terminal region of band_7	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
CMS2_k127_1591100_2	237368.SCABRO_03733	2.069e-65	227.0	COG0428@1|root,COG0428@2|Bacteria,2J10N@203682|Planctomycetes	203682|Planctomycetes	P	transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
CMS2_k127_1597026_6	521045.Kole_0571	1.938e-34	139.0	COG1005@1|root,COG1005@2|Bacteria	2|Bacteria	C	quinone binding	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
CMS2_k127_1597026_5	410358.Mlab_0957	3.15e-41	167.0	COG3260@1|root,arCOG01553@2157|Archaea,2Y8IV@28890|Euryarchaeota,2NAU2@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.12.7.2	ko:K18023	-	-	R00019	-	ko00000,ko01000	-	-	-	Oxidored_q6
CMS2_k127_1597026_11	521045.Kole_0569	4.138e-19	96.0	COG0852@1|root,COG0852@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
CMS2_k127_1597026_0	521045.Kole_0568	3.543e-151	488.0	COG3261@1|root,COG3261@2|Bacteria	2|Bacteria	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_49kDa,NiFeSe_Hases
CMS2_k127_1597026_2	338966.Ppro_0588	5.182e-97	340.0	COG1009@1|root,COG1009@2|Bacteria,1QV11@1224|Proteobacteria,43CGR@68525|delta/epsilon subdivisions,2X7RW@28221|Deltaproteobacteria	1224|Proteobacteria	C	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
CMS2_k127_1597026_14	797302.Halru_1594	3.071e-14	81.0	COG1563@1|root,COG2111@1|root,arCOG03077@2157|Archaea,arCOG03078@2157|Archaea,2XX82@28890|Euryarchaeota,23V8W@183963|Halobacteria	183963|Halobacteria	P	Multisubunit Na H antiporter, MnhB subunit	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040
CMS2_k127_1597026_12	889378.Spiaf_2325	7.145e-19	98.0	COG2111@1|root,COG2111@2|Bacteria	2|Bacteria	P	Na H antiporter	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MnhB
CMS2_k127_1597026_10	521045.Kole_0566	2.053e-25	117.0	COG1006@1|root,COG1006@2|Bacteria,2GDBG@200918|Thermotogae	200918|Thermotogae	P	oxidoreductase, chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
CMS2_k127_1597026_1	521045.Kole_0565	4.232e-100	350.0	COG0651@1|root,COG0651@2|Bacteria,2GE49@200918|Thermotogae	200918|Thermotogae	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
CMS2_k127_1597026_7	673860.AciM339_0655	2.28e-34	138.0	COG1863@1|root,arCOG03099@2157|Archaea,2XTHH@28890|Euryarchaeota,3F327@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	Na H ion antiporter subunit	phaE	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
CMS2_k127_1597026_13	521045.Kole_0563	7.957e-18	85.0	COG2212@1|root,COG2212@2|Bacteria	2|Bacteria	P	antiporter activity	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
CMS2_k127_1597026_8	521045.Kole_0562	4.168e-29	120.0	COG1320@1|root,COG1320@2|Bacteria	2|Bacteria	P	monovalent cation:proton antiporter activity	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
CMS2_k127_1597026_4	521045.Kole_0561	2.892e-43	165.0	COG1143@1|root,COG1143@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	-	ko:K12143	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4,Flavodoxin_5
CMS2_k127_1597026_9	269796.Rru_A0322	1.348e-25	111.0	COG0680@1|root,COG0680@2|Bacteria,1R3V7@1224|Proteobacteria,2UMM4@28211|Alphaproteobacteria,2JY79@204441|Rhodospirillales	204441|Rhodospirillales	C	Hydrogenase maturation protease	-	-	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
CMS2_k127_1597026_3	518766.Rmar_1623	1.361e-70	248.0	COG3291@1|root,COG3291@2|Bacteria,4PMYH@976|Bacteroidetes	976|Bacteroidetes	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_1618444_2	742740.HMPREF9474_03596	1.065e-31	144.0	COG4692@1|root,COG4692@2|Bacteria	2|Bacteria	G	BNR repeat-like domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,DUF3604,F5_F8_type_C,FIVAR
CMS2_k127_1618444_5	2423.NA23_0204550	1.349e-09	72.0	COG1520@1|root,COG1520@2|Bacteria,2GD9T@200918|Thermotogae	200918|Thermotogae	S	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1618444_1	1403819.BATR01000069_gene2031	3.05e-37	163.0	COG1470@1|root,COG1749@1|root,COG3291@1|root,COG3506@1|root,COG3533@1|root,COG1470@2|Bacteria,COG1749@2|Bacteria,COG3291@2|Bacteria,COG3506@2|Bacteria,COG3533@2|Bacteria,46SQ1@74201|Verrucomicrobia,2IV3A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	N	Erythromycin esterase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1618444_4	1142394.PSMK_04880	2.842e-14	84.0	COG2165@1|root,COG2165@2|Bacteria,2IY1V@203682|Planctomycetes	203682|Planctomycetes	NU	TIGRFAM prepilin-type N-terminal cleavage methylation domain	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_1618444_3	313628.LNTAR_00440	7.213e-27	114.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_1635526_2	243232.MJ_0234	2.939e-61	218.0	COG0547@1|root,arCOG02012@2157|Archaea,2XT3C@28890|Euryarchaeota,23QA4@183939|Methanococci	183939|Methanococci	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
CMS2_k127_1635526_3	398767.Glov_1212	2.533e-50	186.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,42QQ3@68525|delta/epsilon subdivisions,2WNPH@28221|Deltaproteobacteria,43U0C@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
CMS2_k127_1635526_0	857087.Metme_0605	4.064e-154	496.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1XDTI@135618|Methylococcales	135618|Methylococcales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_1635526_1	339860.Msp_1075	4.695e-75	261.0	COG0159@1|root,arCOG01086@2157|Archaea,2XTAW@28890|Euryarchaeota,23NJK@183925|Methanobacteria	183925|Methanobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
CMS2_k127_1635526_4	1278073.MYSTI_00286	8.5e-47	180.0	COG1225@1|root,COG1225@2|Bacteria,1RD2X@1224|Proteobacteria,430VE@68525|delta/epsilon subdivisions,2WVX8@28221|Deltaproteobacteria,2YVEC@29|Myxococcales	28221|Deltaproteobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
CMS2_k127_1638093_8	521674.Plim_1710	2.349e-17	95.0	COG0706@1|root,COG0706@2|Bacteria,2IYA0@203682|Planctomycetes	203682|Planctomycetes	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,PDZ_2,YidC_periplas
CMS2_k127_1638093_2	344747.PM8797T_30332	3.123e-76	283.0	COG0639@1|root,COG0639@2|Bacteria,2IYH6@203682|Planctomycetes	203682|Planctomycetes	T	COG0639 Diadenosine tetraphosphatase and related	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
CMS2_k127_1638093_1	1262914.BN533_01315	2.237e-79	272.0	COG1137@1|root,COG1137@2|Bacteria,1UJSV@1239|Firmicutes,4H1UQ@909932|Negativicutes	909932|Negativicutes	S	ABC transporter, ATP-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
CMS2_k127_1638093_7	158189.SpiBuddy_2286	7.635e-35	139.0	COG0242@1|root,COG0242@2|Bacteria,2J7X0@203691|Spirochaetes	203691|Spirochaetes	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
CMS2_k127_1638093_3	1267535.KB906767_gene3958	8.015e-66	238.0	COG0223@1|root,COG0223@2|Bacteria,3Y32C@57723|Acidobacteria,2JHUK@204432|Acidobacteriia	204432|Acidobacteriia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
CMS2_k127_1638093_4	1123242.JH636434_gene4168	2.269e-60	229.0	COG0144@1|root,COG0144@2|Bacteria,2J09U@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
CMS2_k127_1638093_0	886293.Sinac_0002	2.105e-85	302.0	COG0593@1|root,COG0593@2|Bacteria,2IWXU@203682|Planctomycetes	203682|Planctomycetes	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
CMS2_k127_1638093_5	1121430.JMLG01000002_gene1035	6.967e-55	200.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,261IR@186807|Peptococcaceae	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
CMS2_k127_1643432_10	1168034.FH5T_03280	6.293e-23	106.0	COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	dppX	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
CMS2_k127_1643432_8	756272.Plabr_2327	4.695e-27	117.0	2E296@1|root,32XEW@2|Bacteria,2J070@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1643432_3	1313304.CALK_0657	2.109e-103	352.0	COG0124@1|root,COG0124@2|Bacteria	2|Bacteria	J	histidine-tRNA ligase activity	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
CMS2_k127_1643432_9	595460.RRSWK_00887	1.222e-26	113.0	COG0727@1|root,COG0727@2|Bacteria,2IZU5@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
CMS2_k127_1643432_4	1125863.JAFN01000001_gene2317	3.135e-97	322.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2WING@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_3075	QueC
CMS2_k127_1643432_2	143224.JQMD01000002_gene121	1.323e-107	365.0	COG3119@1|root,COG3119@2|Bacteria,4NE6V@976|Bacteroidetes,1HZ00@117743|Flavobacteriia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_1643432_7	314230.DSM3645_18836	7.967e-43	162.0	COG0780@1|root,COG0780@2|Bacteria,2J07W@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
CMS2_k127_1643432_1	1123373.ATXI01000023_gene1785	3.078e-116	396.0	COG0438@1|root,COG0438@2|Bacteria,2GHK9@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1643432_5	575540.Isop_0876	1.242e-58	218.0	COG2931@1|root,COG2931@2|Bacteria,2J1K0@203682|Planctomycetes	203682|Planctomycetes	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1643432_0	1267535.KB906767_gene4768	1.194e-152	508.0	2DBP2@1|root,2ZA71@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1643432_6	251229.Chro_0715	1.366e-52	210.0	COG5492@1|root,COG5492@2|Bacteria,1G6CW@1117|Cyanobacteria,3VK1Y@52604|Pleurocapsales	1117|Cyanobacteria	NQ	Polysaccharide lyase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_lyase
CMS2_k127_1654550_2	1123508.JH636442_gene4191	6.2e-112	372.0	COG3591@1|root,COG3591@2|Bacteria,2IXPD@203682|Planctomycetes	203682|Planctomycetes	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
CMS2_k127_1654550_8	710687.KI912270_gene3038	2.089e-11	68.0	COG2152@1|root,COG2152@2|Bacteria,2HNS8@201174|Actinobacteria,233RX@1762|Mycobacteriaceae	201174|Actinobacteria	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
CMS2_k127_1654550_5	314292.VAS14_15769	2.157e-20	106.0	2DBFB@1|root,2Z8XA@2|Bacteria,1MVTN@1224|Proteobacteria,1RM97@1236|Gammaproteobacteria,1XUIN@135623|Vibrionales	135623|Vibrionales	S	Protein of unknown function (DUF4056)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4056
CMS2_k127_1654550_9	595460.RRSWK_06051	5.736e-05	46.0	COG0526@1|root,COG0526@2|Bacteria,2J2C6@203682|Planctomycetes	203682|Planctomycetes	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS2_k127_1654550_4	1123242.JH636435_gene1290	8.092e-27	119.0	COG0526@1|root,COG0526@2|Bacteria,2J2C6@203682|Planctomycetes	203682|Planctomycetes	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS2_k127_1654550_7	1047013.AQSP01000139_gene2325	1.08e-17	95.0	COG3595@1|root,COG3595@2|Bacteria,2NQ1F@2323|unclassified Bacteria	2|Bacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS2_k127_1654550_1	1297742.A176_02604	5.453e-136	470.0	COG1404@1|root,COG3227@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3227@2|Bacteria,COG3291@2|Bacteria,1RFYD@1224|Proteobacteria,439R3@68525|delta/epsilon subdivisions,2X53R@28221|Deltaproteobacteria,2Z02M@29|Myxococcales	28221|Deltaproteobacteria	O	Bacterial pre-peptidase C-terminal domain	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PPC
CMS2_k127_1654550_0	1449126.JQKL01000047_gene2724	9.712e-312	969.0	COG3968@1|root,COG3968@2|Bacteria,1UHUF@1239|Firmicutes,2481B@186801|Clostridia,26A0R@186813|unclassified Clostridiales	186801|Clostridia	S	Glutamine synthetase type III N terminal	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
CMS2_k127_1654550_6	153948.NAL212_2029	3.285e-20	97.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNBG@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Pfam Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_1660212_8	886293.Sinac_5446	6.164e-24	104.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_1660212_2	1142394.PSMK_24980	5.461e-101	341.0	COG0472@1|root,COG0472@2|Bacteria,2IXU1@203682|Planctomycetes	203682|Planctomycetes	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4
CMS2_k127_1660212_3	324057.Pjdr2_3893	3.155e-75	270.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,4HACR@91061|Bacilli,26S7E@186822|Paenibacillaceae	91061|Bacilli	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS2_k127_1660212_11	762903.Pedsa_1064	3.126e-18	96.0	COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1IPCG@117747|Sphingobacteriia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
CMS2_k127_1660212_9	1396141.BATP01000055_gene2876	1.348e-23	112.0	COG1595@1|root,COG1595@2|Bacteria,46V3P@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
CMS2_k127_1660212_0	886293.Sinac_5445	2.222e-112	377.0	COG0515@1|root,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,TPR_8,WD40
CMS2_k127_1660212_13	710243.XP_007595649.1	2.394e-09	71.0	COG0604@1|root,KOG1198@2759|Eukaryota	2759|Eukaryota	C	oxidoreductase activity	IFR1	GO:0003674,GO:0003824,GO:0004029,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0008150,GO:0008152,GO:0010033,GO:0010035,GO:0010038,GO:0014070,GO:0016491,GO:0016620,GO:0016903,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0046688,GO:0050896,GO:0055114,GO:1901426,GO:1901700	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS2_k127_1660212_1	596151.DesfrDRAFT_1057	1.138e-109	372.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,42NKY@68525|delta/epsilon subdivisions,2WJJG@28221|Deltaproteobacteria,2M8PB@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS2_k127_1660212_10	344747.PM8797T_12373	3.717e-20	105.0	COG1305@1|root,COG1305@2|Bacteria,2IYTT@203682|Planctomycetes	203682|Planctomycetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
CMS2_k127_1660212_6	1234364.AMSF01000017_gene1450	2.31e-53	207.0	COG1305@1|root,COG1305@2|Bacteria,1RARF@1224|Proteobacteria,1RZBM@1236|Gammaproteobacteria,1X4YD@135614|Xanthomonadales	135614|Xanthomonadales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
CMS2_k127_1660212_4	1123514.KB905899_gene479	2.314e-70	243.0	COG0586@1|root,COG0586@2|Bacteria,1R5SJ@1224|Proteobacteria,1S99C@1236|Gammaproteobacteria,463J4@72273|Thiotrichales	72273|Thiotrichales	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS2_k127_1660212_5	1336243.JAEA01000003_gene2322	3.899e-69	242.0	2CCYR@1|root,32RG3@2|Bacteria,1N4Z3@1224|Proteobacteria,2URBW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1660212_7	511437.Lbuc_0484	2.326e-41	161.0	COG2826@1|root,COG2826@2|Bacteria,1TWVR@1239|Firmicutes,4HCM1@91061|Bacilli,3F5JW@33958|Lactobacillaceae	91061|Bacilli	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve
CMS2_k127_1660212_12	204669.Acid345_4484	6.994e-17	83.0	COG3250@1|root,COG3250@2|Bacteria,3Y47P@57723|Acidobacteria,2JKBC@204432|Acidobacteriia	204432|Acidobacteriia	G	Beta galactosidase small chain	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
CMS2_k127_1687850_0	13689.BV96_04745	6.213e-89	310.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K2UN@204457|Sphingomonadales	204457|Sphingomonadales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
CMS2_k127_1687850_1	1131813.AQVT01000001_gene1167	7.961e-70	246.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,1JZ15@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
CMS2_k127_1687850_2	5762.XP_002669540.1	2.565e-10	67.0	2CJGI@1|root,2S3TN@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
CMS2_k127_1696623_2	344747.PM8797T_06060	1.353e-126	419.0	COG0673@1|root,COG0673@2|Bacteria,2IXJ0@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_1696623_3	452637.Oter_1254	1.537e-116	382.0	COG0519@1|root,COG0519@2|Bacteria,46SIW@74201|Verrucomicrobia,3K77S@414999|Opitutae	2|Bacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
CMS2_k127_1696623_0	886293.Sinac_0920	2.057e-162	524.0	COG0673@1|root,COG0673@2|Bacteria,2IWZW@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_1696623_1	1121406.JAEX01000001_gene171	3.95e-159	513.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MXG@68525|delta/epsilon subdivisions,2WJ6G@28221|Deltaproteobacteria,2M81S@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_1696623_4	886293.Sinac_2391	1.22e-69	246.0	COG0454@1|root,COG0454@2|Bacteria,2J1E7@203682|Planctomycetes	203682|Planctomycetes	K	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_170395_1	1123242.JH636434_gene4078	9.43e-96	321.0	COG0500@1|root,COG2226@2|Bacteria,2IXEP@203682|Planctomycetes	203682|Planctomycetes	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
CMS2_k127_170395_2	1279009.ADICEAN_02287	1.057e-61	224.0	COG2021@1|root,COG2021@2|Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS2_k127_170395_0	1185876.BN8_05302	1.455e-126	421.0	COG3934@1|root,COG3934@2|Bacteria,4NG6S@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
CMS2_k127_170395_3	313606.M23134_05330	1.416e-55	207.0	COG0823@1|root,COG0823@2|Bacteria,4PME8@976|Bacteroidetes,47Y2Q@768503|Cytophagia	976|Bacteroidetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_170395_4	794903.OPIT5_02220	1.555e-05	56.0	COG2165@1|root,COG2165@2|Bacteria,46YGW@74201|Verrucomicrobia,3K9JK@414999|Opitutae	414999|Opitutae	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS2_k127_1708635_3	153721.MYP_1907	1.934e-46	169.0	COG0823@1|root,COG0823@2|Bacteria,4NG4S@976|Bacteroidetes,47KMG@768503|Cytophagia	976|Bacteroidetes	U	WD40-like Beta Propeller Repeat	tolB3	-	-	-	-	-	-	-	-	-	-	-	PD40
CMS2_k127_1708635_2	1142394.PSMK_28120	1.93e-56	222.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	senX3	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K07636,ko:K07768,ko:K11383	ko02020,map02020	M00434,M00443,M00505	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
CMS2_k127_1708635_7	1219084.AP014508_gene483	7.723e-05	49.0	COG1366@1|root,COG1366@2|Bacteria,2GDAN@200918|Thermotogae	200918|Thermotogae	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS2_k127_1708635_0	1500894.JQNN01000001_gene1814	1.042e-150	496.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,47316@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	xcpR	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
CMS2_k127_1708635_1	1142394.PSMK_28090	9.167e-75	268.0	COG1459@1|root,COG1459@2|Bacteria	2|Bacteria	U	protein transport across the cell outer membrane	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
CMS2_k127_1708635_8	926692.AZYG01000036_gene2580	0.0004037	52.0	COG4972@1|root,COG4972@2|Bacteria,1V19I@1239|Firmicutes,25DJ0@186801|Clostridia,3WAT5@53433|Halanaerobiales	186801|Clostridia	NU	TIGRFAM type IV pilus assembly protein PilM	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
CMS2_k127_1708635_4	1142394.PSMK_28050	1.317e-28	122.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02650	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	N_methyl,SBP_bac_10
CMS2_k127_1708635_6	477974.Daud_0994	4.928e-09	67.0	COG4970@1|root,COG4970@2|Bacteria,1VKZW@1239|Firmicutes,24SDP@186801|Clostridia,263A4@186807|Peptococcaceae	186801|Clostridia	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS2_k127_1721374_10	426368.MmarC7_1742	1.129e-54	198.0	COG1541@1|root,arCOG02620@2157|Archaea,2XU3A@28890|Euryarchaeota,23QM7@183939|Methanococci	183939|Methanococci	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
CMS2_k127_1721374_14	404380.Gbem_2193	8.787e-30	126.0	COG1014@1|root,COG1014@2|Bacteria,1RH9B@1224|Proteobacteria,42SK4@68525|delta/epsilon subdivisions,2WPI8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	iorB-1	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
CMS2_k127_1721374_1	720554.Clocl_1733	4.614e-162	525.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,3WGY5@541000|Ruminococcaceae	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
CMS2_k127_1721374_7	572477.Alvin_0581	2.453e-91	318.0	28KQH@1|root,2ZA8A@2|Bacteria,1R5EQ@1224|Proteobacteria,1RRD9@1236|Gammaproteobacteria,1WXTM@135613|Chromatiales	135613|Chromatiales	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
CMS2_k127_1721374_8	1121403.AUCV01000028_gene2452	3.924e-87	295.0	COG2159@1|root,COG2159@2|Bacteria,1RDRH@1224|Proteobacteria,42T80@68525|delta/epsilon subdivisions,2WPGY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
CMS2_k127_1721374_11	386456.JQKN01000004_gene225	2.407e-46	170.0	COG2050@1|root,arCOG00777@2157|Archaea,2XXGC@28890|Euryarchaeota,23PW5@183925|Methanobacteria	183925|Methanobacteria	Q	PFAM Thioesterase superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
CMS2_k127_1721374_4	518766.Rmar_1923	8.8e-117	386.0	COG0494@1|root,COG1194@1|root,COG0494@2|Bacteria,COG1194@2|Bacteria,4NDZY@976|Bacteroidetes,1FISB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	NUDIX domain	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
CMS2_k127_1721374_3	861299.J421_0086	4.496e-120	395.0	COG0329@1|root,COG0329@2|Bacteria,1ZTEC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EM	Dihydrodipicolinate synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1721374_6	1411123.JQNH01000001_gene3167	3.687e-102	343.0	COG0451@1|root,COG0451@2|Bacteria,1MWQ2@1224|Proteobacteria,2TTJ2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	NAD dependent epimerase/dehydratase family	MA20_28780	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS2_k127_1721374_0	886293.Sinac_7535	2.934e-176	564.0	COG5434@1|root,COG5434@2|Bacteria,2IX4K@203682|Planctomycetes	2|Bacteria	M	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Pectate_lyase_3
CMS2_k127_1721374_9	344747.PM8797T_18384	8.634e-85	301.0	COG0673@1|root,COG0673@2|Bacteria,2IWRC@203682|Planctomycetes	203682|Planctomycetes	S	COGs COG0673 dehydrogenase and related protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_1721374_5	886293.Sinac_2421	2.857e-115	385.0	COG0673@1|root,COG0673@2|Bacteria,2IWZY@203682|Planctomycetes	203682|Planctomycetes	G	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_1721374_13	1434325.AZQN01000003_gene2339	1.03e-32	131.0	28HIE@1|root,2Z7TW@2|Bacteria,4NJBE@976|Bacteroidetes,47M5B@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1721374_15	338963.Pcar_2559	7.562e-23	106.0	2AK5F@1|root,31AVB@2|Bacteria,1Q690@1224|Proteobacteria,432N9@68525|delta/epsilon subdivisions,2WY61@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1721374_2	756272.Plabr_3373	1.439e-124	413.0	28HIE@1|root,2Z7TW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1721374_12	1123008.KB905692_gene185	1.618e-42	170.0	COG3534@1|root,COG3534@2|Bacteria,4NECK@976|Bacteroidetes,2FNNB@200643|Bacteroidia,22WR1@171551|Porphyromonadaceae	976|Bacteroidetes	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
CMS2_k127_1727138_1	653733.Selin_2111	1.015e-26	127.0	291BV@1|root,2ZNYU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1727138_0	370438.PTH_1466	1.346e-81	279.0	COG0463@1|root,COG0463@2|Bacteria,1UI8D@1239|Firmicutes,247P4@186801|Clostridia,267CB@186807|Peptococcaceae	186801|Clostridia	H	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_1727138_3	443143.GM18_2426	0.0005402	53.0	COG1287@1|root,COG1287@2|Bacteria,1N1IK@1224|Proteobacteria,42RRN@68525|delta/epsilon subdivisions,2WNAY@28221|Deltaproteobacteria,43SI2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1727138_2	1303518.CCALI_02009	6.345e-20	96.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_175577_0	706587.Desti_5383	3.339e-130	421.0	COG0437@1|root,COG0437@2|Bacteria,1RFQZ@1224|Proteobacteria,42S7Q@68525|delta/epsilon subdivisions,2WNQJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11
CMS2_k127_175577_5	1305735.JAFT01000004_gene260	4.222e-15	87.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria,2PCUS@252301|Oceanicola	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
CMS2_k127_175577_4	65093.PCC7418_1759	6.26e-30	126.0	COG1309@1|root,COG1309@2|Bacteria,1GAB1@1117|Cyanobacteria	1117|Cyanobacteria	K	AefR-like transcriptional repressor, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_7,TetR_N
CMS2_k127_175577_2	1265505.ATUG01000001_gene4210	7.698e-51	182.0	COG0662@1|root,COG0662@2|Bacteria,1N1T5@1224|Proteobacteria,42V1T@68525|delta/epsilon subdivisions,2WRU3@28221|Deltaproteobacteria,2MP7U@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS2_k127_175577_1	1123242.JH636435_gene2613	3.834e-63	225.0	COG1595@1|root,COG1595@2|Bacteria,2IZZP@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
CMS2_k127_175577_3	497964.CfE428DRAFT_2981	6.693e-50	184.0	COG0515@1|root,COG0515@2|Bacteria,46U28@74201|Verrucomicrobia	74201|Verrucomicrobia	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF1648,DUF4019,Pkinase
CMS2_k127_1774545_0	247633.GP2143_17936	7.206e-111	371.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1RRTD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_1774545_4	794903.OPIT5_25630	1.068e-22	107.0	COG4968@1|root,COG4968@2|Bacteria,46VVB@74201|Verrucomicrobia,3K9MA@414999|Opitutae	414999|Opitutae	NU	Prepilin-type N-terminal cleavage methylation domain	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_1774545_2	497964.CfE428DRAFT_4845	4.771e-32	142.0	COG3712@1|root,COG3712@2|Bacteria,46WUN@74201|Verrucomicrobia	74201|Verrucomicrobia	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
CMS2_k127_1774545_5	243090.RB10049	3.44e-09	65.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	rfaY	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_1774545_3	1278307.KB906968_gene2032	2.083e-30	121.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SWYU@1236|Gammaproteobacteria,2QJ81@267894|Psychromonadaceae	1236|Gammaproteobacteria	K	Ribonuclease B OB domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CMS2_k127_1774545_1	373903.Hore_13580	9.542e-36	146.0	COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,3WC51@53433|Halanaerobiales	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
CMS2_k127_177680_10	656024.FsymDg_3117	1.175e-27	123.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4ERN7@85013|Frankiales	201174|Actinobacteria	M	Penicillin-binding protein, dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
CMS2_k127_177680_12	512565.AMIS_48540	9.179e-08	63.0	COG1652@1|root,COG1652@2|Bacteria	2|Bacteria	S	positive regulation of growth rate	-	-	-	-	-	-	-	-	-	-	-	-	B_lectin,LysM
CMS2_k127_177680_5	1089553.Tph_c12560	1.195e-71	253.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,42EWY@68295|Thermoanaerobacterales	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
CMS2_k127_177680_11	1449126.JQKL01000021_gene69	2.199e-19	95.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,268ZM@186813|unclassified Clostridiales	186801|Clostridia	K	MraZ protein, putative antitoxin-like	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
CMS2_k127_177680_9	709991.Odosp_3098	2.857e-30	130.0	COG1496@1|root,COG1496@2|Bacteria,4NM9H@976|Bacteroidetes,2FN7X@200643|Bacteroidia,22XMH@171551|Porphyromonadaceae	976|Bacteroidetes	S	Belongs to the multicopper oxidase YfiH RL5 family	-	GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0046983,GO:0055114	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
CMS2_k127_177680_13	1210884.HG799465_gene11644	0.0006801	49.0	2EQDK@1|root,33HZN@2|Bacteria,2J1FY@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_177680_4	1142394.PSMK_28460	1.147e-78	271.0	COG0740@1|root,COG0740@2|Bacteria,2IXQN@203682|Planctomycetes	203682|Planctomycetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
CMS2_k127_177680_6	1142394.PSMK_18100	1.869e-65	234.0	COG0740@1|root,COG0740@2|Bacteria,2IYFK@203682|Planctomycetes	203682|Planctomycetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
CMS2_k127_177680_7	1142394.PSMK_15390	2.498e-55	213.0	COG0544@1|root,COG0544@2|Bacteria,2IXGD@203682|Planctomycetes	203682|Planctomycetes	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	Trigger_C,Trigger_N
CMS2_k127_177680_8	1121403.AUCV01000110_gene2531	2.37e-32	137.0	28I1S@1|root,2Z86A@2|Bacteria	2|Bacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_177680_0	1267535.KB906767_gene5488	0.0	1748.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,3Y2JQ@57723|Acidobacteria,2JHR5@204432|Acidobacteriia	204432|Acidobacteriia	E	GXGXG motif	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
CMS2_k127_177680_2	1191523.MROS_0711	1.798e-175	565.0	COG0493@1|root,COG0493@2|Bacteria	2|Bacteria	C	'glutamate synthase	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450	Fer4_20,Pyr_redox_2
CMS2_k127_177680_1	671143.DAMO_2142	0.0	1442.0	COG0458@1|root,COG0458@2|Bacteria,2NNPB@2323|unclassified Bacteria	2|Bacteria	EF	Carbamoyl-phosphate synthetase ammonia chain	carB	GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041	CPSase_L_D2,CPSase_L_D3,MGS
CMS2_k127_177680_3	338963.Pcar_1613	5.962e-131	429.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2WIQ5@28221|Deltaproteobacteria,43SCX@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
CMS2_k127_1794399_12	1396141.BATP01000003_gene4934	1.409e-24	121.0	COG2312@1|root,COG2312@2|Bacteria	2|Bacteria	S	response to antibiotic	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Erythro_esteras,LTD
CMS2_k127_1794399_5	1396141.BATP01000033_gene4252	1.21e-105	377.0	COG2312@1|root,COG2312@2|Bacteria,46XSC@74201|Verrucomicrobia,2IWGQ@203494|Verrucomicrobiae	2|Bacteria	M	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Erythro_esteras,LTD
CMS2_k127_1794399_0	761193.Runsl_0644	3.096e-215	672.0	COG1482@1|root,COG1482@2|Bacteria,4NGGP@976|Bacteroidetes,47NZ6@768503|Cytophagia	976|Bacteroidetes	G	cell wall glycoprotein biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1794399_1	886293.Sinac_5697	1.522e-196	617.0	COG0673@1|root,COG0673@2|Bacteria,2IWTD@203682|Planctomycetes	203682|Planctomycetes	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_1794399_2	497964.CfE428DRAFT_0715	2.552e-189	595.0	COG1082@1|root,COG1082@2|Bacteria,46TGS@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_1794399_6	375451.RD1_3873	2.265e-102	340.0	COG1082@1|root,COG1082@2|Bacteria,1PJSY@1224|Proteobacteria,2V9JN@28211|Alphaproteobacteria,2P44I@2433|Roseobacter	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.1.3.30,5.1.3.31	ko:K18910	-	-	R10817,R10818	RC03111,RC03283	ko00000,ko01000	-	-	-	AP_endonuc_2
CMS2_k127_1794399_4	1502852.FG94_02591	8.645e-122	399.0	COG1621@1|root,COG1621@2|Bacteria,1NR4M@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
CMS2_k127_1794399_10	292415.Tbd_1057	7.215e-36	144.0	COG3663@1|root,COG3663@2|Bacteria,1REPV@1224|Proteobacteria,2VRAT@28216|Betaproteobacteria,1KSZ9@119069|Hydrogenophilales	119069|Hydrogenophilales	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
CMS2_k127_1794399_3	1125863.JAFN01000001_gene2904	6.752e-152	500.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	PFAM Type II secretion system protein E	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N,cNMP_binding
CMS2_k127_1794399_7	639282.DEFDS_1110	5.645e-100	337.0	COG2805@1|root,COG2805@2|Bacteria,2GEWK@200930|Deferribacteres	200930|Deferribacteres	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS2_k127_1794399_8	373903.Hore_05990	2.333e-67	244.0	COG1459@1|root,COG1459@2|Bacteria,1TQRZ@1239|Firmicutes,249FV@186801|Clostridia,3WAFC@53433|Halanaerobiales	186801|Clostridia	U	PFAM Bacterial type II secretion system protein F domain	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
CMS2_k127_1794399_15	1121374.KB891585_gene2108	1.808e-05	52.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	General Secretion Pathway protein	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
CMS2_k127_1794399_17	864702.OsccyDRAFT_1068	0.0009536	48.0	COG2165@1|root,COG2165@2|Bacteria,1G6VB@1117|Cyanobacteria,1HBR3@1150|Oscillatoriales	1117|Cyanobacteria	NU	Prepilin-type N-terminal cleavage methylation domain	gsp	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin_GH
CMS2_k127_1794399_16	38727.Pavir.Aa02721.1.p	0.0004424	45.0	2C5YW@1|root,2QTCM@2759|Eukaryota,37N6Q@33090|Viridiplantae,3GBCH@35493|Streptophyta,3KXRM@4447|Liliopsida,3IFE7@38820|Poales	35493|Streptophyta	S	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_12
CMS2_k127_1794399_14	745411.B3C1_02740	7.932e-11	74.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1J4VC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	COG4972 Tfp pilus assembly protein, ATPase PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
CMS2_k127_1794399_9	1492922.GY26_16365	1.079e-48	193.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1J4IY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Type II secretory pathway, component	pilQ	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	-	ko:K02507,ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
CMS2_k127_1794399_13	794903.OPIT5_01015	2.03e-22	106.0	COG0705@1|root,COG0705@2|Bacteria,46V9T@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS2_k127_1794399_11	497964.CfE428DRAFT_5266	3.657e-31	128.0	COG1520@1|root,COG1520@2|Bacteria,46THI@74201|Verrucomicrobia	74201|Verrucomicrobia	S	SMART Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_1806104_1	517418.Ctha_1693	1.945e-119	389.0	COG0686@1|root,COG0686@2|Bacteria,1FEIP@1090|Chlorobi	1090|Chlorobi	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
CMS2_k127_1806104_4	489825.LYNGBM3L_44400	1.312e-05	58.0	COG1361@1|root,COG2304@1|root,COG3170@1|root,COG3391@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG3170@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,1G2M0@1117|Cyanobacteria,1HD4B@1150|Oscillatoriales	1117|Cyanobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
CMS2_k127_1806104_0	886293.Sinac_4629	3.854e-147	480.0	COG0673@1|root,COG0673@2|Bacteria,2IWX9@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_1806104_2	886293.Sinac_4026	2.68e-61	217.0	COG1595@1|root,COG1595@2|Bacteria,2IZ8A@203682|Planctomycetes	203682|Planctomycetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_1806104_3	452637.Oter_4175	8.078e-26	112.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,46VB0@74201|Verrucomicrobia,3K8AK@414999|Opitutae	414999|Opitutae	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_1829570_6	1121904.ARBP01000040_gene522	4.989e-23	99.0	COG0823@1|root,COG0823@2|Bacteria,4NQ0C@976|Bacteroidetes,47PP7@768503|Cytophagia	976|Bacteroidetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1829570_2	203119.Cthe_0186	8.944e-116	381.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,3WGFI@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
CMS2_k127_1829570_0	1209989.TepiRe1_1688	6.306e-132	434.0	COG5026@1|root,COG5026@2|Bacteria,1TRWA@1239|Firmicutes,24BV4@186801|Clostridia	186801|Clostridia	G	PFAM hexokinase	-	-	2.7.1.1	ko:K00844	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04910,ko04930,ko04973,ko05230,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200,map04066,map04910,map04930,map04973,map05230	M00001,M00549	R00299,R00760,R00867,R01326,R01600,R01786,R01961,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	Hexokinase_1,Hexokinase_2
CMS2_k127_1829570_4	517418.Ctha_1865	4.013e-85	310.0	COG5184@1|root,COG5492@1|root,COG5184@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,CHU_C,Calx-beta,ChW,Flg_new,Glug,Phage_TTP_12,RCC1
CMS2_k127_1829570_1	573061.Clocel_1892	1.186e-127	421.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,36EE0@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
CMS2_k127_1829570_3	1411123.JQNH01000001_gene3813	1.774e-110	367.0	COG0280@1|root,COG0280@2|Bacteria,1QTS5@1224|Proteobacteria,2TVFP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	phosphate acetyltransferase	-	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
CMS2_k127_1829570_5	909663.KI867150_gene2237	1.905e-70	246.0	COG0034@1|root,COG0034@2|Bacteria,1R7JX@1224|Proteobacteria,42MAC@68525|delta/epsilon subdivisions,2WKFD@28221|Deltaproteobacteria,2MQ6P@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Glutamine amidotransferase domain	-	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7
CMS2_k127_1832394_11	290317.Cpha266_0823	1.398e-13	74.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
CMS2_k127_1832394_16	937777.Deipe_2067	8.558e-05	47.0	COG1783@1|root,COG1783@2|Bacteria	2|Bacteria	S	DNA packaging	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_3,Terminase_3C
CMS2_k127_1832394_2	742817.HMPREF9449_02410	2.31e-74	262.0	COG1605@1|root,COG2876@1|root,COG1605@2|Bacteria,COG2876@2|Bacteria,4NDU4@976|Bacteroidetes,2FPF1@200643|Bacteroidia,22WB4@171551|Porphyromonadaceae	976|Bacteroidetes	E	Cytochrome C4	pheB	-	5.4.99.5	ko:K04516	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,DAHP_synth_1
CMS2_k127_1832394_0	926550.CLDAP_19500	3.739e-97	362.0	COG0584@1|root,COG0823@1|root,COG3210@1|root,COG4886@1|root,COG0584@2|Bacteria,COG0823@2|Bacteria,COG3210@2|Bacteria,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	3.1.4.46	ko:K01126,ko:K21449	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000,ko02000	1.B.40.2	-	-	GDPD_2
CMS2_k127_1832394_6	1262449.CP6013_0770	1.636e-24	123.0	COG0457@1|root,COG3266@1|root,COG4676@1|root,COG4870@1|root,COG0457@2|Bacteria,COG3266@2|Bacteria,COG4676@2|Bacteria,COG4870@2|Bacteria,1VDA3@1239|Firmicutes	1239|Firmicutes	O	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Flg_new,TPR_19
CMS2_k127_1832394_15	717605.Theco_0148	4.531e-05	58.0	COG1572@1|root,COG3291@1|root,COG1572@2|Bacteria,COG3291@2|Bacteria,1TQH4@1239|Firmicutes,4HEBG@91061|Bacilli,26UYZ@186822|Paenibacillaceae	91061|Bacilli	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
CMS2_k127_1832394_12	192952.MM_2804	7.449e-12	79.0	arCOG03499@1|root,arCOG03499@2157|Archaea	2157|Archaea	G	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Disaggr_assoc,Disaggr_repeat,PKD
CMS2_k127_1832394_13	1304874.JAFY01000002_gene803	7.978e-07	63.0	COG3210@1|root,COG3210@2|Bacteria,3TB3U@508458|Synergistetes	508458|Synergistetes	U	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_1832394_5	357808.RoseRS_1743	8.616e-51	207.0	COG4932@1|root,COG4932@2|Bacteria,2G7MG@200795|Chloroflexi,376NW@32061|Chloroflexia	32061|Chloroflexia	M	PFAM Cna B domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1832394_10	1219065.VPR01S_06_01980	1.722e-14	88.0	COG4932@1|root,COG4932@2|Bacteria,1QKVS@1224|Proteobacteria,1TJ1A@1236|Gammaproteobacteria,1Y09E@135623|Vibrionales	135623|Vibrionales	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1832394_7	883096.HMPREF9699_00068	5.9e-18	100.0	COG1262@1|root,COG1262@2|Bacteria,4NEUZ@976|Bacteroidetes,1HYG0@117743|Flavobacteriia	976|Bacteroidetes	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
CMS2_k127_1832394_3	1185876.BN8_04554	6.649e-67	259.0	COG2730@1|root,COG4124@1|root,COG2730@2|Bacteria,COG4124@2|Bacteria,4NNCY@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Cellulase
CMS2_k127_1832394_17	1250005.PHEL85_2540	8.829e-05	56.0	COG3210@1|root,COG3420@1|root,COG3210@2|Bacteria,COG3420@2|Bacteria,4NPFX@976|Bacteroidetes,1IIJZ@117743|Flavobacteriia	976|Bacteroidetes	GPU	Putative binding domain, N-terminal	-	-	4.2.2.3	ko:K01729	ko00051,map00051	-	R03706	-	ko00000,ko00001,ko01000	-	-	-	BACON,Chondroitinas_B,F5_F8_type_C
CMS2_k127_1832394_18	1123278.KB893422_gene1562	0.0001958	47.0	COG2374@1|root,COG2931@1|root,COG3391@1|root,COG4932@1|root,COG5434@1|root,COG5492@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,COG5434@2|Bacteria,COG5492@2|Bacteria,4NR3S@976|Bacteroidetes,47RKF@768503|Cytophagia	976|Bacteroidetes	Q	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS2_k127_1832394_14	177437.HRM2_39540	8.183e-06	49.0	COG2963@1|root,COG2963@2|Bacteria,1NGD6@1224|Proteobacteria,42X6G@68525|delta/epsilon subdivisions,2WT2N@28221|Deltaproteobacteria,2MMEI@213118|Desulfobacterales	28221|Deltaproteobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
CMS2_k127_1832394_9	107636.JQNK01000001_gene45	6.477e-15	77.0	COG3344@1|root,COG3344@2|Bacteria	2|Bacteria	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
CMS2_k127_1832394_8	172088.AUGA01000114_gene4277	7.379e-18	89.0	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2U9U2@28211|Alphaproteobacteria,3K6N1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	IS66 C-terminal element	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
CMS2_k127_1832394_4	344747.PM8797T_27367	2.304e-62	219.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_1832394_1	886293.Sinac_4025	3.096e-89	299.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,TPR_8,WD40
CMS2_k127_1833344_2	1303518.CCALI_00933	7.097e-13	79.0	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_1833344_1	644282.Deba_1899	8.847e-69	253.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
CMS2_k127_1833344_0	382464.ABSI01000013_gene1549	2.794e-94	341.0	COG2312@1|root,COG3211@1|root,COG2312@2|Bacteria,COG3211@2|Bacteria,46XD5@74201|Verrucomicrobia,2IVHX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Fn3_assoc,LTD
CMS2_k127_184168_3	886293.Sinac_4622	2.19e-46	171.0	COG3119@1|root,COG3119@2|Bacteria,2IYNZ@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_184168_1	641524.ADICYQ_0727	1.351e-98	343.0	28HHT@1|root,2Z7TE@2|Bacteria,4NIHS@976|Bacteroidetes,47MAA@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_184168_2	383372.Rcas_4353	1.888e-46	172.0	COG0614@1|root,COG0614@2|Bacteria,2G9KR@200795|Chloroflexi,377DT@32061|Chloroflexia	32061|Chloroflexia	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
CMS2_k127_184168_0	411477.PARMER_00704	2.886e-111	364.0	COG1233@1|root,COG1233@2|Bacteria,4PKWE@976|Bacteroidetes,2FNQX@200643|Bacteroidia,231HP@171551|Porphyromonadaceae	976|Bacteroidetes	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
CMS2_k127_1856726_16	1499967.BAYZ01000009_gene5298	7.983e-43	159.0	COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
CMS2_k127_1856726_8	595460.RRSWK_03120	2.842e-96	335.0	COG0515@1|root,COG0515@2|Bacteria,2IYAA@203682|Planctomycetes	203682|Planctomycetes	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_1856726_26	211165.AJLN01000106_gene5760	1.352e-09	61.0	2BTZ9@1|root,32P7U@2|Bacteria,1GA1G@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1856726_25	756272.Plabr_3500	4.817e-17	89.0	COG1763@1|root,COG1763@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	-	ko:K03753,ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	-
CMS2_k127_1856726_21	497964.CfE428DRAFT_3013	1.275e-27	119.0	2E6X2@1|root,331GI@2|Bacteria,46T38@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1856726_7	439235.Dalk_3089	2.719e-99	347.0	2A102@1|root,30P5F@2|Bacteria,1NQ9E@1224|Proteobacteria,433GU@68525|delta/epsilon subdivisions,2WXXA@28221|Deltaproteobacteria	1224|Proteobacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DUF3592
CMS2_k127_1856726_1	1227352.C173_11400	2.518e-163	539.0	COG3669@1|root,COG3669@2|Bacteria,1TSG7@1239|Firmicutes,4HEKS@91061|Bacilli,26UH5@186822|Paenibacillaceae	91061|Bacilli	G	alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,F5_F8_type_C
CMS2_k127_1856726_22	1142394.PSMK_20830	3.823e-27	119.0	COG0558@1|root,COG0558@2|Bacteria,2IZQ1@203682|Planctomycetes	203682|Planctomycetes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS2_k127_1856726_5	521674.Plim_0735	5.753e-111	374.0	COG0621@1|root,COG0621@2|Bacteria,2IWTE@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
CMS2_k127_1856726_24	443143.GM18_1385	1.493e-18	100.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,43UJ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	PFAM type II and III secretion system protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
CMS2_k127_1856726_10	756272.Plabr_4342	2.558e-74	259.0	COG0052@1|root,COG0052@2|Bacteria,2IY9P@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
CMS2_k127_1856726_12	387092.NIS_1536	2.866e-61	221.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2YMQW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
CMS2_k127_1856726_9	290397.Adeh_0280	1.637e-78	269.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,2YU4R@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
CMS2_k127_1856726_15	756272.Plabr_4345	1.058e-47	177.0	COG0233@1|root,COG0233@2|Bacteria,2IYYY@203682|Planctomycetes	203682|Planctomycetes	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
CMS2_k127_1856726_20	530564.Psta_2133	1.907e-30	141.0	COG3164@1|root,COG3164@2|Bacteria,2IXXM@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1856726_18	595460.RRSWK_01774	5.474e-34	147.0	COG1295@1|root,COG1295@2|Bacteria,2J0M6@203682|Planctomycetes	203682|Planctomycetes	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
CMS2_k127_1856726_19	1122176.KB903532_gene2707	7.397e-33	146.0	COG1409@1|root,COG1409@2|Bacteria,4NGK2@976|Bacteroidetes,1IYA9@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Fn3_assoc,Metallophos,PA14,Pur_ac_phosph_N
CMS2_k127_1856726_17	644282.Deba_1923	7.057e-37	147.0	COG1280@1|root,COG1280@2|Bacteria,1RJBR@1224|Proteobacteria,42T9G@68525|delta/epsilon subdivisions,2WP76@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
CMS2_k127_1856726_11	2325.TKV_c14790	3.181e-74	252.0	COG0432@1|root,COG0432@2|Bacteria,1V201@1239|Firmicutes,24FTY@186801|Clostridia,42G53@68295|Thermoanaerobacterales	186801|Clostridia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CMS2_k127_1856726_0	706587.Desti_4338	4.567e-209	653.0	COG2502@1|root,COG2502@2|Bacteria,1MVWF@1224|Proteobacteria	1224|Proteobacteria	E	aspartate--ammonia ligase	asnA	GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	-	R00483	RC00010	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299	AsnA,tRNA-synt_2
CMS2_k127_1856726_6	575540.Isop_0532	1.757e-100	341.0	COG0438@1|root,COG0438@2|Bacteria,2IXN1@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_1856726_14	247490.KSU1_D0726	1.564e-56	205.0	COG0101@1|root,COG0101@2|Bacteria,2IYSC@203682|Planctomycetes	203682|Planctomycetes	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
CMS2_k127_1856726_2	1038859.AXAU01000001_gene3142	4.407e-130	424.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria,3JV4V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
CMS2_k127_1856726_13	1499685.CCFJ01000045_gene2821	4.75e-61	226.0	COG0385@1|root,COG0385@2|Bacteria,1TP85@1239|Firmicutes,4HBG6@91061|Bacilli,1ZB6V@1386|Bacillus	91061|Bacilli	S	-transporter	yocS	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	iYO844.BSU19350	SBF
CMS2_k127_1856726_23	644282.Deba_0046	1.197e-22	102.0	COG0745@1|root,COG2202@1|root,COG3829@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,1NWNJ@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HWE_HK,PAS,PAS_3,PAS_4,PAS_9
CMS2_k127_1856726_3	1232410.KI421428_gene1119	1.965e-129	430.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,43UDA@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM peptidase S1 and S6, chymotrypsin Hap	degP	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS2_k127_1856726_27	42256.RradSPS_0759	8.862e-08	59.0	COG1595@1|root,COG1595@2|Bacteria,2HXZ9@201174|Actinobacteria,4CQ7U@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_1856726_4	595460.RRSWK_05050	5.179e-113	377.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
CMS2_k127_1858098_4	251221.35212995	3.195e-119	404.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_1858098_3	251221.35211765	9.595e-130	445.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS2_k127_1858098_1	452637.Oter_1855	1.514e-185	608.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS2_k127_1858098_5	234267.Acid_6478	3.312e-105	345.0	COG1136@1|root,COG1136@2|Bacteria,3Y2X0@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS2_k127_1858098_2	452637.Oter_1855	1.638e-155	520.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS2_k127_1858098_0	452637.Oter_1827	2.021e-197	642.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS2_k127_1858098_6	240015.ACP_1397	1.03e-15	80.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria,2JI3C@204432|Acidobacteriia	204432|Acidobacteriia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS2_k127_187301_29	391613.RTM1035_15512	3.866e-29	125.0	COG2244@1|root,COG2244@2|Bacteria,1MUMD@1224|Proteobacteria,2TTZ8@28211|Alphaproteobacteria,46NWY@74030|Roseovarius	28211|Alphaproteobacteria	S	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3
CMS2_k127_187301_28	246196.MSMEI_5805	1.092e-30	143.0	2DQMZ@1|root,337PX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_187301_27	880073.Calab_0526	1.912e-41	178.0	COG1404@1|root,COG3291@1|root,COG3386@1|root,COG5276@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17,3.2.1.4	ko:K01053,ko:K01179,ko:K07214,ko:K12287	ko00030,ko00053,ko00500,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00500,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751,R06200,R11307,R11308	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko02044,ko04147	-	GH5,GH9	-	Big_5,DUF285,Esterase,He_PIG,SGL
CMS2_k127_187301_35	192952.MM_1936	4.804e-15	91.0	arCOG02527@1|root,arCOG02527@2157|Archaea,2XZJV@28890|Euryarchaeota,2NA0Y@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_187301_14	1116472.MGMO_57c00290	1.135e-92	321.0	COG2327@1|root,COG2327@2|Bacteria,1MXWP@1224|Proteobacteria,1RRDB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	biosynthesis protein	wcaK	-	-	ko:K16710	-	-	-	-	ko00000	-	-	iECSF_1327.ECSF_1934,iSBO_1134.SBO_0872	PS_pyruv_trans
CMS2_k127_187301_7	686340.Metal_0332	2.24e-118	397.0	COG4106@1|root,COG4106@2|Bacteria,1R7QP@1224|Proteobacteria	1224|Proteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
CMS2_k127_187301_20	91464.S7335_1742	7.259e-66	243.0	COG0438@1|root,COG0438@2|Bacteria,1GCS0@1117|Cyanobacteria	1117|Cyanobacteria	H	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
CMS2_k127_187301_24	1128427.KB904821_gene4265	9.819e-49	187.0	COG1216@1|root,COG1216@2|Bacteria,1G346@1117|Cyanobacteria,1H7S2@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_187301_21	1173022.Cri9333_2782	4.01e-59	216.0	COG0463@1|root,COG0463@2|Bacteria,1GDMZ@1117|Cyanobacteria,1HGCF@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_187301_2	269799.Gmet_2332	1.304e-169	543.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42N6P@68525|delta/epsilon subdivisions,2WJVY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.33	ko:K20429	-	-	R02773	RC00006,RC00781	ko00000,ko01000	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_187301_6	313596.RB2501_11342	2.718e-120	399.0	COG3246@1|root,COG3246@2|Bacteria,4NGNQ@976|Bacteroidetes,1I7AI@117743|Flavobacteriia	976|Bacteroidetes	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
CMS2_k127_187301_22	1283299.AUKG01000002_gene4028	3.199e-51	189.0	COG0110@1|root,COG0110@2|Bacteria,2IDUP@201174|Actinobacteria,4CTGD@84995|Rubrobacteria	84995|Rubrobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
CMS2_k127_187301_15	1317118.ATO8_08326	5.604e-84	301.0	COG2244@1|root,COG2244@2|Bacteria,1PHY1@1224|Proteobacteria,2UQ94@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_187301_39	1316936.K678_09863	9.148e-07	59.0	COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2TUKE@28211|Alphaproteobacteria,2JS30@204441|Rhodospirillales	204441|Rhodospirillales	C	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3485,Exosortase_EpsH
CMS2_k127_187301_38	1123392.AQWL01000009_gene1064	3.327e-08	64.0	COG1266@1|root,COG1266@2|Bacteria,1RJZQ@1224|Proteobacteria,2VSUQ@28216|Betaproteobacteria,1KSZ8@119069|Hydrogenophilales	119069|Hydrogenophilales	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
CMS2_k127_187301_33	1265505.ATUG01000001_gene3006	2.687e-17	93.0	COG3031@1|root,COG3031@2|Bacteria,1PUWN@1224|Proteobacteria,42T73@68525|delta/epsilon subdivisions,2WPQU@28221|Deltaproteobacteria,2MK5Q@213118|Desulfobacterales	28221|Deltaproteobacteria	U	General secretion pathway protein C	gspC	-	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	PDZ_2,T2SSC
CMS2_k127_187301_12	1125863.JAFN01000001_gene2970	5.151e-102	360.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Type II and III secretion system protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
CMS2_k127_187301_3	1125863.JAFN01000001_gene2969	1.33e-162	527.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	PFAM Type II secretion system protein E	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
CMS2_k127_187301_19	404589.Anae109_0728	7.459e-79	277.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2YTZT@29|Myxococcales	28221|Deltaproteobacteria	U	General secretion pathway protein F	gspF	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
CMS2_k127_187301_26	1232410.KI421418_gene2155	1.884e-42	160.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2WP3B@28221|Deltaproteobacteria,43UZB@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Type II secretion system (T2SS), protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
CMS2_k127_187301_41	1234364.AMSF01000088_gene2717	8.729e-05	50.0	COG2165@1|root,COG2165@2|Bacteria,1NIHW@1224|Proteobacteria,1SE3Y@1236|Gammaproteobacteria,1X7PX@135614|Xanthomonadales	135614|Xanthomonadales	NU	General secretion pathway protein	xpsI	-	-	ko:K02458	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_187301_42	575788.VS_0141	0.0001316	52.0	COG4795@1|root,COG4795@2|Bacteria,1RJAE@1224|Proteobacteria,1S5ZZ@1236|Gammaproteobacteria,1XU01@135623|Vibrionales	135623|Vibrionales	U	general secretion pathway protein	epsJ	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
CMS2_k127_187301_32	868864.Dester_1332	9.272e-21	104.0	COG3156@1|root,COG3156@2|Bacteria,2G4RD@200783|Aquificae	200783|Aquificae	U	Type II secretion system (T2SS), protein K	-	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
CMS2_k127_187301_40	1232437.KL662039_gene2102	1.249e-06	61.0	COG4972@1|root,COG4972@2|Bacteria,1MYIB@1224|Proteobacteria,42SIX@68525|delta/epsilon subdivisions,2WP1G@28221|Deltaproteobacteria,2MKAU@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Fimbrial assembly family protein	gspL	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspL_C,PilM_2,PilN,T2SSL
CMS2_k127_187301_37	1232410.KI421418_gene2149	3.23e-10	68.0	COG3149@1|root,COG3149@2|Bacteria,1Q1NE@1224|Proteobacteria,43EXY@68525|delta/epsilon subdivisions,2X2IW@28221|Deltaproteobacteria,43VM5@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_187301_31	1121940.AUDZ01000016_gene88	3.624e-25	106.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1XM5A@135619|Oceanospirillales	135619|Oceanospirillales	K	cold-shock protein	cspG	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CMS2_k127_187301_5	497964.CfE428DRAFT_3317	1.276e-133	459.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,Cellulase,Glyco_hydro_2_C,Glyco_hydro_42,Glycos_transf_2
CMS2_k127_187301_1	595460.RRSWK_00437	9.345e-209	669.0	COG1874@1|root,COG1874@2|Bacteria,2J2PX@203682|Planctomycetes	203682|Planctomycetes	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_187301_16	177437.HRM2_23720	7.89e-84	290.0	COG4866@1|root,COG4866@2|Bacteria,1RIUZ@1224|Proteobacteria,42P4H@68525|delta/epsilon subdivisions,2WPMI@28221|Deltaproteobacteria,2MM47@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
CMS2_k127_187301_23	247490.KSU1_C0729	6.547e-49	190.0	COG0616@1|root,COG0616@2|Bacteria,2IYKF@203682|Planctomycetes	203682|Planctomycetes	OU	TIGRFAM signal peptide peptidase SppA, 36K type	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
CMS2_k127_187301_34	1185876.BN8_04387	1.529e-16	93.0	COG3934@1|root,COG3934@2|Bacteria,4NHVX@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Glyco_hydro_2_C
CMS2_k127_187301_8	886293.Sinac_5953	1.182e-109	373.0	COG0621@1|root,COG0621@2|Bacteria,2IX1E@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
CMS2_k127_187301_13	697281.Mahau_0525	2.109e-98	337.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,247Z9@186801|Clostridia,42GQ8@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Radical SAM domain protein	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS2_k127_187301_18	1123508.JH636443_gene4950	3.71e-82	287.0	COG0617@1|root,COG0617@2|Bacteria,2IXYM@203682|Planctomycetes	203682|Planctomycetes	H	tRNA nucleotidyltransferase poly(A) polymerase	papS	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
CMS2_k127_187301_30	398767.Glov_1770	8.385e-29	129.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,42U1F@68525|delta/epsilon subdivisions,2WWMK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
CMS2_k127_187301_0	368407.Memar_2216	5.77e-265	834.0	COG0380@1|root,arCOG02831@2157|Archaea,2XSTE@28890|Euryarchaeota	28890|Euryarchaeota	G	COG0380 Trehalose-6-phosphate synthase	otsA	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
CMS2_k127_187301_4	1047013.AQSP01000140_gene2507	1.615e-150	485.0	COG0438@1|root,COG0438@2|Bacteria,2NQMN@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	treT	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
CMS2_k127_187301_25	886293.Sinac_5145	7.654e-46	171.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_187301_9	1142394.PSMK_00010	3.827e-104	353.0	COG0593@1|root,COG0593@2|Bacteria,2IWXU@203682|Planctomycetes	203682|Planctomycetes	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
CMS2_k127_187301_11	247490.KSU1_C0960	3.511e-102	341.0	COG0552@1|root,COG0552@2|Bacteria,2IXAG@203682|Planctomycetes	203682|Planctomycetes	D	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
CMS2_k127_187301_10	1492737.FEM08_16470	1.159e-102	343.0	COG1680@1|root,COG1680@2|Bacteria,4P506@976|Bacteroidetes	976|Bacteroidetes	V	COG1680 Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1884418_6	289376.THEYE_A0616	8.435e-18	87.0	COG1146@1|root,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	vorD	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_21,Fer4_4,Fer4_7
CMS2_k127_1884418_5	518766.Rmar_2866	7.786e-33	136.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
CMS2_k127_1884418_7	1042877.GQS_04255	1.378e-14	80.0	COG1895@1|root,arCOG02123@2157|Archaea,2Y0VD@28890|Euryarchaeota,2446Z@183968|Thermococci	183968|Thermococci	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_1884418_2	555079.Toce_0834	4.011e-130	425.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,42F8P@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase	vorB	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
CMS2_k127_1884418_3	555079.Toce_0835	9.79e-100	331.0	COG1013@1|root,COG1013@2|Bacteria,1UZ67@1239|Firmicutes,247Q7@186801|Clostridia,42FFP@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
CMS2_k127_1884418_4	373903.Hore_06800	2.606e-50	185.0	COG1014@1|root,COG1014@2|Bacteria,1UYYG@1239|Firmicutes,24I53@186801|Clostridia,3WB03@53433|Halanaerobiales	186801|Clostridia	C	PFAM Pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
CMS2_k127_1884418_1	1121904.ARBP01000013_gene454	3.128e-138	461.0	COG3540@1|root,COG3540@2|Bacteria,4NDUS@976|Bacteroidetes,47NKM@768503|Cytophagia	976|Bacteroidetes	P	PhoD-like phosphatase	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD
CMS2_k127_1884418_0	926550.CLDAP_19940	0.0	1063.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
CMS2_k127_1886798_5	1304874.JAFY01000001_gene2612	5.692e-23	109.0	COG3210@1|root,COG4447@1|root,COG3210@2|Bacteria,COG4447@2|Bacteria,3TB3U@508458|Synergistetes	508458|Synergistetes	U	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_1886798_6	1123242.JH636435_gene2480	1.199e-18	93.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_1886798_1	1121904.ARBP01000016_gene5270	4.506e-68	237.0	COG0300@1|root,COG0300@2|Bacteria,4NIAI@976|Bacteroidetes,47MJU@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
CMS2_k127_1886798_8	644282.Deba_1076	7.26e-06	56.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,42M8S@68525|delta/epsilon subdivisions,2WNG8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
CMS2_k127_1886798_7	370438.PTH_2198	9.507e-16	88.0	COG2401@1|root,COG2401@2|Bacteria,1VR03@1239|Firmicutes,24ZUD@186801|Clostridia,264JV@186807|Peptococcaceae	186801|Clostridia	S	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS2_k127_1886798_4	1150626.PHAMO_80065	2.077e-37	151.0	COG2401@1|root,COG2401@2|Bacteria,1R423@1224|Proteobacteria,2UWW8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1886798_0	349521.HCH_01563	1.082e-98	335.0	COG0657@1|root,COG0657@2|Bacteria,1R4AU@1224|Proteobacteria,1RQMN@1236|Gammaproteobacteria,1XR8Q@135619|Oceanospirillales	135619|Oceanospirillales	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
CMS2_k127_1886798_2	439235.Dalk_3108	2.851e-63	229.0	COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,43BDR@68525|delta/epsilon subdivisions,2X6SB@28221|Deltaproteobacteria,2MPIC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM SagB-type dehydrogenase domain	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS2_k127_1886798_3	768710.DesyoDRAFT_2386	3.134e-45	186.0	COG5373@1|root,COG5373@2|Bacteria,1UUGX@1239|Firmicutes,24EBQ@186801|Clostridia,26413@186807|Peptococcaceae	186801|Clostridia	S	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
CMS2_k127_1908074_1	1123242.JH636434_gene5339	2.979e-180	576.0	COG0673@1|root,COG0673@2|Bacteria,2IXA3@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_1908074_2	1123242.JH636434_gene5340	2.75e-35	141.0	COG1413@1|root,COG1413@2|Bacteria,2IZE1@203682|Planctomycetes	203682|Planctomycetes	C	E-Z type HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
CMS2_k127_1940573_0	411477.PARMER_03655	4e-269	860.0	COG3250@1|root,COG3250@2|Bacteria,4NIBS@976|Bacteroidetes,2FPZ2@200643|Bacteroidia,22ZBT@171551|Porphyromonadaceae	976|Bacteroidetes	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
CMS2_k127_1940573_2	1382359.JIAL01000001_gene3040	1.753e-138	448.0	COG0697@1|root,2Z7ID@2|Bacteria,3Y46C@57723|Acidobacteria,2JJ04@204432|Acidobacteriia	204432|Acidobacteriia	EG	PFAM RhaT l-rhamnose-proton symport 2	-	-	-	ko:K02856	-	-	-	-	ko00000,ko02000	2.A.7.6	-	-	RhaT
CMS2_k127_1940573_1	1499967.BAYZ01000095_gene4068	1.655e-195	615.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
CMS2_k127_1944634_1	1242864.D187_004218	5.269e-19	93.0	COG1595@1|root,COG1595@2|Bacteria,1N413@1224|Proteobacteria,42SGS@68525|delta/epsilon subdivisions,2WPQ9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_1944634_0	1396141.BATP01000034_gene4199	2.943e-163	546.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,Collagen,F5_F8_type_C,FIVAR,Glyco_hydro_43,Laminin_G_3,Metallophos
CMS2_k127_1944634_2	644966.Tmar_0683	1.925e-06	58.0	COG2021@1|root,COG2021@2|Bacteria,1UMHR@1239|Firmicutes,25GIJ@186801|Clostridia,3WDQ0@538999|Clostridiales incertae sedis	186801|Clostridia	E	TIGRFAM proline-specific peptidases, Bacillus coagulans-type subfamily	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
CMS2_k127_1948499_1	1306406.ASHX01000001_gene4469	7.674e-49	186.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,DUF11,PKD,PPC
CMS2_k127_1948499_0	240016.ABIZ01000001_gene1588	2.791e-74	265.0	COG0673@1|root,COG0673@2|Bacteria,46TM9@74201|Verrucomicrobia,2ITZ3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_1948499_3	323850.Shew_0509	1.129e-10	65.0	2EGDM@1|root,33A5H@2|Bacteria,1NJMK@1224|Proteobacteria,1SIKC@1236|Gammaproteobacteria,2QDZ1@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1955634_21	70601.3257629	8.269e-10	66.0	COG1525@1|root,arCOG03192@2157|Archaea,2XTIT@28890|Euryarchaeota,2447M@183968|Thermococci	183968|Thermococci	L	Staphylococcal nuclease homologues	-	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	LTD,SNase
CMS2_k127_1955634_4	247490.KSU1_C1278	4.673e-128	421.0	COG0527@1|root,COG0527@2|Bacteria,2IY8N@203682|Planctomycetes	203682|Planctomycetes	E	aspartate kinase, monofunctional class	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
CMS2_k127_1955634_3	237368.SCABRO_01725	3.186e-130	426.0	COG3635@1|root,COG3635@2|Bacteria,2IXCZ@203682|Planctomycetes	203682|Planctomycetes	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
CMS2_k127_1955634_5	665571.STHERM_c01940	2.446e-125	415.0	COG0460@1|root,COG0460@2|Bacteria,2J89J@203691|Spirochaetes	203691|Spirochaetes	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
CMS2_k127_1955634_1	1150600.ADIARSV_4037	1.076e-136	449.0	28HII@1|root,2Z7TZ@2|Bacteria,4NHR6@976|Bacteroidetes,1INR1@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1955634_13	639282.DEFDS_0733	2.629e-36	157.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.2.1.51,4.2.2.23	ko:K01206,ko:K18197	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29,PL11	-	AbfB,Bgal_small_N,CBM_6,F5_F8_type_C,Glyco_hydro_2_N,NPCBM
CMS2_k127_1955634_19	926556.Echvi_3939	3.704e-12	79.0	COG3119@1|root,COG3866@1|root,COG3119@2|Bacteria,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,47MVU@768503|Cytophagia	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1955634_22	555779.Dthio_PD2898	1.687e-07	59.0	COG0642@1|root,COG2203@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MH92@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,DUF3365,HAMP,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg
CMS2_k127_1955634_16	1304883.KI912532_gene2867	1.925e-22	102.0	COG4585@1|root,COG4585@2|Bacteria,1RGET@1224|Proteobacteria,2VPRS@28216|Betaproteobacteria,2KZ4H@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
CMS2_k127_1955634_10	237368.SCABRO_00310	7.908e-60	226.0	COG2027@1|root,COG2027@2|Bacteria,2IYAC@203682|Planctomycetes	203682|Planctomycetes	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
CMS2_k127_1955634_18	1122132.AQYH01000020_gene21	1.365e-14	87.0	COG1807@1|root,COG1807@2|Bacteria,1R7IS@1224|Proteobacteria,2U51N@28211|Alphaproteobacteria,4BJ8A@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS2_k127_1955634_14	237368.SCABRO_00714	2.661e-31	138.0	COG1253@1|root,COG1253@2|Bacteria,2J0AW@203682|Planctomycetes	203682|Planctomycetes	S	COG1253 Hemolysins and related	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
CMS2_k127_1955634_8	237368.SCABRO_00715	1.146e-67	248.0	COG1253@1|root,COG1253@2|Bacteria,2IYEG@203682|Planctomycetes	203682|Planctomycetes	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
CMS2_k127_1955634_12	530564.Psta_2875	2.404e-45	176.0	COG4191@1|root,COG4191@2|Bacteria,2IYZD@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS2_k127_1955634_11	575540.Isop_2462	5.634e-48	176.0	COG3437@1|root,COG3437@2|Bacteria,2J516@203682|Planctomycetes	203682|Planctomycetes	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_1955634_17	7918.ENSLOCP00000018276	6.934e-20	104.0	COG0457@1|root,COG3914@1|root,KOG1124@2759|Eukaryota,KOG4626@2759|Eukaryota,38EM5@33154|Opisthokonta,3BC3N@33208|Metazoa,3CWN6@33213|Bilateria,4870C@7711|Chordata,48X60@7742|Vertebrata,49R5B@7898|Actinopterygii	33208|Metazoa	GOT	O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1	OGT	GO:0000003,GO:0000123,GO:0000785,GO:0000791,GO:0001678,GO:0001932,GO:0001933,GO:0001934,GO:0002119,GO:0002164,GO:0002237,GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0005488,GO:0005515,GO:0005543,GO:0005547,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0006040,GO:0006041,GO:0006047,GO:0006048,GO:0006073,GO:0006091,GO:0006109,GO:0006110,GO:0006111,GO:0006112,GO:0006139,GO:0006140,GO:0006325,GO:0006355,GO:0006357,GO:0006464,GO:0006470,GO:0006473,GO:0006475,GO:0006479,GO:0006486,GO:0006493,GO:0006508,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006996,GO:0007005,GO:0007154,GO:0007165,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007444,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0007626,GO:0008080,GO:0008134,GO:0008150,GO:0008152,GO:0008194,GO:0008213,GO:0008219,GO:0008289,GO:0008361,GO:0008375,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009605,GO:0009607,GO:0009617,GO:0009636,GO:0009719,GO:0009725,GO:0009743,GO:0009746,GO:0009749,GO:0009791,GO:0009888,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009966,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010562,GO:0010563,GO:0010604,GO:0010605,GO:0010628,GO:0010638,GO:0010646,GO:0010675,GO:0010799,GO:0010801,GO:0010876,GO:0010906,GO:0010941,GO:0012501,GO:0012505,GO:0015980,GO:0016020,GO:0016043,GO:0016262,GO:0016311,GO:0016407,GO:0016410,GO:0016485,GO:0016569,GO:0016570,GO:0016571,GO:0016573,GO:0016579,GO:0016740,GO:0016746,GO:0016747,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0018022,GO:0018023,GO:0018130,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019725,GO:0019904,GO:0019915,GO:0022607,GO:0023051,GO:0023052,GO:0030141,GO:0030162,GO:0030246,GO:0030808,GO:0030811,GO:0030900,GO:0031056,GO:0031058,GO:0031060,GO:0031062,GO:0031248,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0031396,GO:0031397,GO:0031399,GO:0031400,GO:0031401,GO:0031410,GO:0031667,GO:0031974,GO:0031981,GO:0031982,GO:0032259,GO:0032268,GO:0032269,GO:0032270,GO:0032386,GO:0032387,GO:0032434,GO:0032435,GO:0032496,GO:0032501,GO:0032502,GO:0032535,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032880,GO:0032922,GO:0032991,GO:0033036,GO:0033043,GO:0033044,GO:0033135,GO:0033137,GO:0033157,GO:0033218,GO:0033500,GO:0033993,GO:0034284,GO:0034641,GO:0034645,GO:0034654,GO:0034968,GO:0035020,GO:0035091,GO:0035220,GO:0035295,GO:0035556,GO:0036094,GO:0036211,GO:0036477,GO:0040024,GO:0042176,GO:0042177,GO:0042221,GO:0042277,GO:0042325,GO:0042326,GO:0042327,GO:0042578,GO:0042588,GO:0042592,GO:0042593,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043255,GO:0043412,GO:0043413,GO:0043414,GO:0043434,GO:0043467,GO:0043470,GO:0043543,GO:0043933,GO:0043967,GO:0043981,GO:0043982,GO:0043984,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044271,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045475,GO:0045793,GO:0045861,GO:0045862,GO:0045893,GO:0045935,GO:0045936,GO:0045937,GO:0045944,GO:0046349,GO:0046483,GO:0046578,GO:0046626,GO:0048015,GO:0048017,GO:0048029,GO:0048311,GO:0048312,GO:0048471,GO:0048511,GO:0048512,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051051,GO:0051056,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051193,GO:0051196,GO:0051223,GO:0051224,GO:0051235,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051276,GO:0051291,GO:0051568,GO:0051604,GO:0051640,GO:0051641,GO:0051646,GO:0051704,GO:0051707,GO:0051716,GO:0055082,GO:0055086,GO:0055114,GO:0060255,GO:0060322,GO:0060341,GO:0060429,GO:0060548,GO:0061085,GO:0061087,GO:0061136,GO:0062012,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0070085,GO:0070201,GO:0070206,GO:0070207,GO:0070208,GO:0070646,GO:0070647,GO:0070887,GO:0071216,GO:0071219,GO:0071222,GO:0071310,GO:0071322,GO:0071326,GO:0071331,GO:0071333,GO:0071375,GO:0071396,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0080182,GO:0090066,GO:0090087,GO:0090313,GO:0090315,GO:0090317,GO:0097237,GO:0097363,GO:0097458,GO:0097708,GO:0099503,GO:0120025,GO:0140096,GO:1900037,GO:1900038,GO:1900076,GO:1900180,GO:1900182,GO:1900371,GO:1900542,GO:1901071,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901799,GO:1901981,GO:1902275,GO:1902493,GO:1902494,GO:1902531,GO:1902680,GO:1903050,GO:1903051,GO:1903320,GO:1903321,GO:1903362,GO:1903363,GO:1903426,GO:1903428,GO:1903506,GO:1903508,GO:1903533,GO:1903578,GO:1903827,GO:1903828,GO:1903829,GO:1904950,GO:1905269,GO:1905475,GO:1905476,GO:1990234,GO:2000058,GO:2000059,GO:2000112,GO:2000377,GO:2000379,GO:2001141,GO:2001169,GO:2001252	2.4.1.255	ko:K09667	ko00514,ko04931,map00514,map04931	-	R09304,R09676	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003,ko03036	-	GT41	-	Glyco_transf_41,TPR_1,TPR_11,TPR_2,TPR_8
CMS2_k127_1955634_6	575540.Isop_2875	1.132e-120	395.0	COG4864@1|root,COG4864@2|Bacteria,2IXDK@203682|Planctomycetes	203682|Planctomycetes	S	UPF0365 protein	-	-	-	-	-	-	-	-	-	-	-	-	YdfA_immunity
CMS2_k127_1955634_15	886293.Sinac_1415	1.214e-23	106.0	COG1030@1|root,COG1030@2|Bacteria,2J0K3@203682|Planctomycetes	203682|Planctomycetes	O	Membrane-bound serine protease (ClpP class)	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
CMS2_k127_1955634_9	96561.Dole_0020	1.531e-66	248.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,2MI54@213118|Desulfobacterales	28221|Deltaproteobacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
CMS2_k127_1955634_20	247490.KSU1_D0085	1.693e-11	70.0	COG1826@1|root,COG1826@2|Bacteria,2J1B7@203682|Planctomycetes	203682|Planctomycetes	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
CMS2_k127_1955634_2	368408.Tpen_1559	5.399e-136	450.0	COG2407@1|root,arCOG01772@2157|Archaea	2157|Archaea	G	L-fucose isomerase and related	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1955634_7	1123278.KB893433_gene684	7.773e-114	374.0	COG2273@1|root,COG2273@2|Bacteria,4NF91@976|Bacteroidetes,47MDE@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolases family 16	-	-	-	-	-	-	-	-	-	-	-	-	DUF1735,Glyco_hydro_16,Glyco_hydro_43
CMS2_k127_1955634_0	497964.CfE428DRAFT_5426	9.979e-268	842.0	COG1680@1|root,COG1680@2|Bacteria,46WGY@74201|Verrucomicrobia	74201|Verrucomicrobia	V	COG1680 Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_1955980_1	234267.Acid_2655	3.734e-133	430.0	COG3669@1|root,COG3669@2|Bacteria,3Y3XG@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glycoside hydrolase, family 29	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
CMS2_k127_1955980_0	1449063.JMLS01000017_gene685	1.1e-322	1007.0	COG1082@1|root,COG1082@2|Bacteria,1UFEU@1239|Firmicutes	1239|Firmicutes	G	Glycosyl-hydrolase 97 C-terminal, oligomerisation	-	-	-	-	-	-	-	-	-	-	-	-	GH97_C,GH97_N,Glyco_hydro_97
CMS2_k127_1955980_2	1122605.KB893648_gene3691	9.178e-54	194.0	COG1554@1|root,COG1554@2|Bacteria,4NKKJ@976|Bacteroidetes,1IV2Y@117747|Sphingobacteriia	976|Bacteroidetes	G	Glycosyl hydrolase family 65, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hyd_65N_2
CMS2_k127_1967954_5	1214101.BN159_0623	8.583e-17	81.0	COG3293@1|root,COG3293@2|Bacteria,2IGHY@201174|Actinobacteria	201174|Actinobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
CMS2_k127_1967954_0	105559.Nwat_1142	8.65e-113	371.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales	135613|Chromatiales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
CMS2_k127_1967954_4	880073.Calab_1319	1.114e-48	188.0	COG1249@1|root,COG1249@2|Bacteria,2NQMY@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3)	lpdA	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006103,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006520,GO:0006544,GO:0006546,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009071,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015036,GO:0016054,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017144,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019464,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0036211,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045250,GO:0045252,GO:0045254,GO:0046390,GO:0046395,GO:0046483,GO:0046496,GO:0046872,GO:0046914,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0065007,GO:0065008,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0097159,GO:0106077,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAPECO1_1312.APECO1_1869,iEcolC_1368.EcolC_3543,iPC815.YPO3417,iSFV_1184.SFV_0107,iUMN146_1321.UM146_23385	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
CMS2_k127_1967954_3	398512.JQKC01000050_gene2642	4.759e-58	228.0	COG5184@1|root,COG5184@2|Bacteria,1UZD4@1239|Firmicutes,2486M@186801|Clostridia,3WM05@541000|Ruminococcaceae	186801|Clostridia	DZ	Regulator of chromosome condensation (RCC1) repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like,RCC1_2
CMS2_k127_1967954_2	886293.Sinac_4026	3.198e-58	207.0	COG1595@1|root,COG1595@2|Bacteria,2IZ8A@203682|Planctomycetes	203682|Planctomycetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_1967954_1	886293.Sinac_4025	5.332e-64	226.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,TPR_8,WD40
CMS2_k127_1982613_2	1302858.I871_01760	2.396e-22	112.0	COG0148@1|root,COG0148@2|Bacteria,2J59Y@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
CMS2_k127_1982613_0	1123508.JH636439_gene1032	4.331e-55	200.0	COG0688@1|root,COG0688@2|Bacteria,2IXE7@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
CMS2_k127_1982613_1	344747.PM8797T_11294	1.412e-40	162.0	COG1183@1|root,COG1183@2|Bacteria,2IZHR@203682|Planctomycetes	203682|Planctomycetes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
CMS2_k127_1982613_4	661478.OP10G_2992	6.786e-14	81.0	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_1982613_5	639283.Snov_0110	3.06e-08	66.0	COG4625@1|root,COG4625@2|Bacteria,1MU92@1224|Proteobacteria,2TSB7@28211|Alphaproteobacteria,3EYIX@335928|Xanthobacteraceae	28211|Alphaproteobacteria	U	Autotransporter beta-domain	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,PATR
CMS2_k127_1982613_6	1034769.KB910518_gene1041	4.346e-05	56.0	COG1621@1|root,COG3204@1|root,COG3533@1|root,COG3940@1|root,COG1621@2|Bacteria,COG3204@2|Bacteria,COG3533@2|Bacteria,COG3940@2|Bacteria,1U157@1239|Firmicutes,4HT9T@91061|Bacilli,26UV2@186822|Paenibacillaceae	91061|Bacilli	G	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,Laminin_G_3
CMS2_k127_1982613_3	1303518.CCALI_00340	9.577e-16	84.0	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_1986093_3	373903.Hore_13580	3.339e-40	155.0	COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,3WC51@53433|Halanaerobiales	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
CMS2_k127_1986093_1	794903.OPIT5_29535	2.82e-83	289.0	COG2197@1|root,COG2197@2|Bacteria,46UGC@74201|Verrucomicrobia,3K7ZK@414999|Opitutae	414999|Opitutae	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS2_k127_1986093_0	794903.OPIT5_22365	3.221e-138	456.0	COG4191@1|root,COG4585@1|root,COG4191@2|Bacteria,COG4585@2|Bacteria,46XZQ@74201|Verrucomicrobia,3K8PF@414999|Opitutae	414999|Opitutae	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
CMS2_k127_1986093_2	278957.ABEA03000005_gene4421	6.72e-47	173.0	COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,46UFT@74201|Verrucomicrobia,3K92E@414999|Opitutae	414999|Opitutae	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80,3.1.1.61	ko:K00575,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,PAS_10
CMS2_k127_2025578_1	1121456.ATVA01000012_gene2571	1.267e-32	135.0	COG1757@1|root,COG1757@2|Bacteria,1MY5C@1224|Proteobacteria,42P0P@68525|delta/epsilon subdivisions,2WN1R@28221|Deltaproteobacteria,2M9Y8@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
CMS2_k127_2025578_0	391615.ABSJ01000045_gene2052	2.192e-153	510.0	COG3356@1|root,COG3356@2|Bacteria,1QW1Q@1224|Proteobacteria	1224|Proteobacteria	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk,Ceramidse_alk_C
CMS2_k127_2036948_7	1123508.JH636449_gene7305	2.282e-98	327.0	COG0154@1|root,COG0154@2|Bacteria,2IXW5@203682|Planctomycetes	203682|Planctomycetes	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS2_k127_2036948_3	1089548.KI783301_gene238	1.737e-137	453.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,4HAFB@91061|Bacilli,3WDZI@539002|Bacillales incertae sedis	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
CMS2_k127_2036948_15	1125863.JAFN01000001_gene752	5.805e-30	122.0	COG1917@1|root,COG1917@2|Bacteria,1N2JS@1224|Proteobacteria,42TR3@68525|delta/epsilon subdivisions,2WQ4M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS2_k127_2036948_16	339670.Bamb_6432	8.142e-23	102.0	COG5470@1|root,COG5470@2|Bacteria,1N7JA@1224|Proteobacteria,2VU5B@28216|Betaproteobacteria,1K8GH@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
CMS2_k127_2036948_19	886293.Sinac_2505	2.399e-07	63.0	2ESSA@1|root,33KAQ@2|Bacteria,2J1KK@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2036948_21	1239962.C943_00122	0.0001839	53.0	COG1413@1|root,COG1413@2|Bacteria,4PNCU@976|Bacteroidetes,47YQP@768503|Cytophagia	976|Bacteroidetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_2036948_13	1142394.PSMK_15030	3.771e-43	167.0	COG0344@1|root,COG0344@2|Bacteria,2J0DJ@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	DUF4149,G3P_acyltransf
CMS2_k127_2036948_14	886293.Sinac_3097	2.538e-37	156.0	COG0438@1|root,COG0438@2|Bacteria,2IZ1G@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferase, group 1	-	-	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_2036948_17	313628.LNTAR_01807	2.439e-10	72.0	COG0515@1|root,COG0515@2|Bacteria	313628.LNTAR_01807|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2036948_0	933262.AXAM01000042_gene1835	6.687e-199	634.0	COG1032@1|root,COG1032@2|Bacteria,1NRWP@1224|Proteobacteria,42S72@68525|delta/epsilon subdivisions,2WNA6@28221|Deltaproteobacteria,2MKAP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_2036948_4	933262.AXAM01000049_gene3264	1.169e-134	447.0	COG0859@1|root,COG0859@2|Bacteria,1P0ST@1224|Proteobacteria	1224|Proteobacteria	M	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2036948_6	933262.AXAM01000049_gene3265	8.305e-124	405.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42NEW@68525|delta/epsilon subdivisions,2WJNJ@28221|Deltaproteobacteria,2MIGM@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM lipopolysaccharide heptosyltransferase II	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS2_k127_2036948_12	479434.Sthe_0041	4.316e-46	179.0	COG0241@1|root,COG0241@2|Bacteria,2G6V8@200795|Chloroflexi,27Z4Y@189775|Thermomicrobia	189775|Thermomicrobia	E	Polynucleotide kinase 3 phosphatase	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
CMS2_k127_2036948_11	1069080.KB913028_gene332	6.926e-49	182.0	COG0279@1|root,COG0279@2|Bacteria,1V5W5@1239|Firmicutes,4H443@909932|Negativicutes	909932|Negativicutes	G	SIS domain	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
CMS2_k127_2036948_5	1210884.HG799465_gene11565	4.616e-130	432.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,2IY6V@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
CMS2_k127_2036948_10	344747.PM8797T_06767	2.117e-64	235.0	COG1663@1|root,COG1663@2|Bacteria,2IXYX@203682|Planctomycetes	203682|Planctomycetes	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
CMS2_k127_2036948_9	1499967.BAYZ01000176_gene5632	1.063e-67	236.0	COG0693@1|root,COG0693@2|Bacteria,2NRMH@2323|unclassified Bacteria	2|Bacteria	S	DJ-1/PfpI family	thiJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006517,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009100,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019538,GO:0022613,GO:0030091,GO:0033554,GO:0034599,GO:0036211,GO:0036524,GO:0036525,GO:0042026,GO:0042221,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0071840,GO:0140096,GO:1901135,GO:1901564	2.7.11.1,3.5.1.124	ko:K03152,ko:K05520,ko:K05687,ko:K12132	ko05012,map05012	-	-	-	ko00000,ko00001,ko01000,ko01001,ko01002,ko04147	-	-	-	DJ-1_PfpI
CMS2_k127_2036948_1	575540.Isop_1279	9.342e-168	534.0	COG0473@1|root,COG0473@2|Bacteria,2IXBE@203682|Planctomycetes	203682|Planctomycetes	C	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CMS2_k127_2036948_8	1047013.AQSP01000130_gene1865	5.318e-95	328.0	COG1680@1|root,COG1680@2|Bacteria,2NPA1@2323|unclassified Bacteria	2|Bacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343,Lipase_GDSL,Lipase_GDSL_2
CMS2_k127_2036948_20	1463920.JOGB01000003_gene2649	1.62e-06	59.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2GMKG@201174|Actinobacteria	201174|Actinobacteria	P	Copper resistance protein CopC	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
CMS2_k127_2036948_2	485915.Dret_1751	4.611e-153	493.0	COG1916@1|root,COG1916@2|Bacteria,1MWJ0@1224|Proteobacteria,42P2H@68525|delta/epsilon subdivisions,2WJQM@28221|Deltaproteobacteria,2MEJK@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM TraB determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	TraB
CMS2_k127_2036948_18	398767.Glov_3157	1.885e-08	66.0	COG0457@1|root,COG1462@1|root,COG0457@2|Bacteria,COG1462@2|Bacteria,1N4V4@1224|Proteobacteria,42WHI@68525|delta/epsilon subdivisions,2WRYH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
CMS2_k127_2046669_2	240016.ABIZ01000001_gene1588	2.047e-48	178.0	COG0673@1|root,COG0673@2|Bacteria,46TM9@74201|Verrucomicrobia,2ITZ3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_2046669_1	1121904.ARBP01000026_gene697	1.468e-79	275.0	COG1082@1|root,COG1082@2|Bacteria,4NGKX@976|Bacteroidetes,47JP9@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_2046669_0	234267.Acid_2416	6.703e-128	424.0	COG4287@1|root,COG4287@2|Bacteria	2|Bacteria	S	PhoPQ-activated pathogenicity-related protein	pqaA	-	-	-	-	-	-	-	-	-	-	-	PhoPQ_related
CMS2_k127_2052424_1	518766.Rmar_1917	1.613e-111	393.0	COG0587@1|root,COG1372@1|root,COG0587@2|Bacteria,COG1372@2|Bacteria,4NFA0@976|Bacteroidetes,1FIKI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	Bacterial DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
CMS2_k127_2052424_5	411489.CLOL250_00947	5.962e-45	171.0	COG0125@1|root,COG0125@2|Bacteria,1V1HE@1239|Firmicutes,24HHC@186801|Clostridia,36GNE@31979|Clostridiaceae	186801|Clostridia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
CMS2_k127_2052424_6	642492.Clole_0013	2.3e-36	152.0	COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia	186801|Clostridia	L	'dna polymerase iii	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
CMS2_k127_2052424_2	247490.KSU1_B0639	1.929e-68	244.0	COG1774@1|root,COG1774@2|Bacteria,2IWZD@203682|Planctomycetes	203682|Planctomycetes	S	signal peptidase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
CMS2_k127_2052424_0	396588.Tgr7_2622	1.78e-242	769.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales	135613|Chromatiales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
CMS2_k127_2052424_8	794903.OPIT5_04965	1.118e-21	98.0	2E5IJ@1|root,3309Y@2|Bacteria,46SYV@74201|Verrucomicrobia,3K87A@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2052424_4	335541.Swol_1076	6.111e-58	230.0	COG5492@1|root,COG5492@2|Bacteria,1V7TS@1239|Firmicutes,25F4B@186801|Clostridia,42KX4@68298|Syntrophomonadaceae	2|Bacteria	N	Surface proteins containing Ig-like domains-like	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CBM_X2,CHB_HEX_C_1,Flg_new,Glug,SLH
CMS2_k127_2052424_7	240016.ABIZ01000001_gene1272	4.141e-31	128.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	ko:K03828	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
CMS2_k127_2052424_3	768706.Desor_2149	1.614e-60	213.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24B81@186801|Clostridia,266XB@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF_2	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
CMS2_k127_2054453_24	665571.STHERM_c06180	1.15e-27	115.0	COG0673@1|root,COG0673@2|Bacteria,2J71R@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_2054453_13	1121904.ARBP01000005_gene4578	8.92e-97	325.0	COG1082@1|root,COG1082@2|Bacteria,4NIWS@976|Bacteroidetes,47K4W@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
CMS2_k127_2054453_4	1288963.ADIS_2076	1.676e-151	491.0	COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,47NH0@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_2054453_17	314230.DSM3645_14090	1.167e-66	239.0	COG1413@1|root,COG3828@1|root,COG1413@2|Bacteria,COG3828@2|Bacteria,2IX8S@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_2054453_1	1499967.BAYZ01000184_gene4559	1.86e-188	594.0	COG0673@1|root,COG0673@2|Bacteria,2NQ5E@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	MA20_02630	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_2054453_6	1499967.BAYZ01000156_gene565	5.067e-136	442.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
CMS2_k127_2054453_2	1499967.BAYZ01000095_gene4213	3.825e-179	577.0	COG0364@1|root,COG0364@2|Bacteria,2NNUR@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iIT341.HP1101	G6PD_C,G6PD_N
CMS2_k127_2054453_25	1304880.JAGB01000002_gene2292	4.633e-25	105.0	COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia	186801|Clostridia	C	rubredoxin	rd	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0017144,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114,GO:0072592	1.18.1.1	ko:K05297	ko00071,map00071	-	R02000	-	ko00000,ko00001,ko01000	-	-	-	Rubredoxin
CMS2_k127_2054453_22	903818.KI912268_gene2028	6.938e-36	142.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_2054453_18	456442.Mboo_0794	1.908e-57	203.0	COG1528@1|root,arCOG01095@2157|Archaea,2XXEN@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM Ferritin Dps family protein	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
CMS2_k127_2054453_19	573370.DMR_17610	2.14e-53	192.0	COG2033@1|root,COG2033@2|Bacteria,1RHE0@1224|Proteobacteria,42SB9@68525|delta/epsilon subdivisions,2WP2D@28221|Deltaproteobacteria,2MBEZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Desulfoferrodoxin ferrous iron-binding region	dfx	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
CMS2_k127_2054453_3	1047013.AQSP01000144_gene920	3.84e-175	556.0	COG0426@1|root,COG0426@2|Bacteria,2NPHV@2323|unclassified Bacteria	2|Bacteria	C	Metallo-beta-lactamase superfamily	dfa1	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Flavodoxin_1,Lactamase_B
CMS2_k127_2054453_15	933262.AXAM01000207_gene938	2.442e-74	255.0	COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,42RE8@68525|delta/epsilon subdivisions,2WNA5@28221|Deltaproteobacteria,2MK12@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA,Redoxin
CMS2_k127_2054453_14	1313304.CALK_1953	1.167e-76	260.0	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	rbr	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_2054453_20	1123371.ATXH01000001_gene1186	1.232e-49	181.0	COG0735@1|root,COG0735@2|Bacteria	2|Bacteria	P	belongs to the Fur family	perR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2000374,GO:2001141	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS2_k127_2054453_10	886293.Sinac_2714	6.709e-126	416.0	COG0673@1|root,COG0673@2|Bacteria,2IXFW@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_2054453_35	1211115.ALIQ01000040_gene3122	0.0001533	51.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,2TVI2@28211|Alphaproteobacteria,3NA3Z@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8
CMS2_k127_2054453_27	439235.Dalk_0886	1.886e-20	103.0	COG1453@1|root,COG1453@2|Bacteria,1QZ5K@1224|Proteobacteria,43CG9@68525|delta/epsilon subdivisions,2X7RA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
CMS2_k127_2054453_30	321327.CYA_0280	2.228e-16	89.0	COG5306@1|root,COG5306@2|Bacteria	2|Bacteria	-	-	exbB2	-	-	ko:K03561,ko:K12287	-	-	-	-	ko00000,ko02000,ko02044	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
CMS2_k127_2054453_8	344747.PM8797T_31193	6.462e-133	438.0	COG0673@1|root,COG0673@2|Bacteria,2IXRR@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_2054453_9	243090.RB7879	6.446e-128	424.0	COG3119@1|root,COG3119@2|Bacteria,2IYH5@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.4	ko:K01132	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00077,M00079	R07806	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
CMS2_k127_2054453_26	1206741.BAFX01000183_gene7621	1.093e-23	113.0	COG0438@1|root,COG0438@2|Bacteria,2HFN4@201174|Actinobacteria,4G7AY@85025|Nocardiaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_2054453_29	96561.Dole_2136	3.081e-17	82.0	COG0454@1|root,COG0456@2|Bacteria,1NW87@1224|Proteobacteria,4305U@68525|delta/epsilon subdivisions,2WVHS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
CMS2_k127_2054453_28	1303518.CCALI_01450	1.564e-17	93.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02679	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_2054453_33	1499967.BAYZ01000141_gene6153	1.266e-08	61.0	COG1262@1|root,COG1262@2|Bacteria,2NR84@2323|unclassified Bacteria	2|Bacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,Peptidase_C14,Pkinase
CMS2_k127_2054453_34	717785.HYPMC_0530	6.727e-06	48.0	2DT3B@1|root,33IHT@2|Bacteria,1NK4F@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2054453_0	1232410.KI421424_gene1631	5.474e-214	689.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,43S2B@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	iAF987.Gmet_0119	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
CMS2_k127_2054453_23	468059.AUHA01000003_gene1458	3.321e-30	126.0	COG1595@1|root,COG1595@2|Bacteria,4NNWH@976|Bacteroidetes,1IRXJ@117747|Sphingobacteriia	976|Bacteroidetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_2054453_31	1120985.AUMI01000014_gene886	3.509e-16	81.0	COG0298@1|root,COG0298@2|Bacteria,1VFE0@1239|Firmicutes,4H5P1@909932|Negativicutes	909932|Negativicutes	O	Hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
CMS2_k127_2054453_11	335543.Sfum_4014	2.512e-113	376.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2WJDQ@28221|Deltaproteobacteria,2MR11@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	iAF987.Gmet_0117	HypD
CMS2_k127_2054453_12	635013.TherJR_1303	5.249e-101	342.0	COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia,260QH@186807|Peptococcaceae	186801|Clostridia	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
CMS2_k127_2054453_32	1123388.AQWU01000040_gene485	4.383e-14	79.0	COG0375@1|root,COG0375@2|Bacteria,1WKU7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Hydrogenase/urease nickel incorporation, metallochaperone, hypA	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
CMS2_k127_2054453_16	644968.DFW101_0524	3.376e-68	238.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,42MMJ@68525|delta/epsilon subdivisions,2WK7X@28221|Deltaproteobacteria,2M883@213115|Desulfovibrionales	28221|Deltaproteobacteria	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
CMS2_k127_2054453_21	1410665.JNKR01000005_gene1593	4.458e-40	156.0	COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,4H2AC@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
CMS2_k127_2054453_5	1123274.KB899416_gene2670	5.499e-145	475.0	COG0019@1|root,COG0019@2|Bacteria,2J5HV@203691|Spirochaetes	203691|Spirochaetes	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
CMS2_k127_2054453_7	756272.Plabr_0466	4.545e-134	435.0	COG0439@1|root,COG0439@2|Bacteria,2IWZV@203682|Planctomycetes	203682|Planctomycetes	I	Biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
CMS2_k127_2071753_2	1167006.UWK_03278	7.949e-97	324.0	COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,42QPE@68525|delta/epsilon subdivisions,2WN39@28221|Deltaproteobacteria,2MKUD@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS2_k127_2071753_0	1049564.TevJSym_ca00050	3.072e-222	713.0	COG1033@1|root,COG2834@1|root,COG1033@2|Bacteria,COG2834@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J96Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	MMPL family	VP1286	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS2_k127_2071753_3	886293.Sinac_5260	1.482e-11	66.0	COG0828@1|root,COG0828@2|Bacteria,2J1A6@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
CMS2_k127_2071753_1	247490.KSU1_B0490	9.695e-119	395.0	COG2262@1|root,COG2262@2|Bacteria,2IXH5@203682|Planctomycetes	203682|Planctomycetes	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
CMS2_k127_2076508_2	706587.Desti_3888	2e-38	151.0	COG0348@1|root,COG0348@2|Bacteria,1Q4BA@1224|Proteobacteria,42Q02@68525|delta/epsilon subdivisions,2WJMU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_10,Fer4_5
CMS2_k127_2076508_4	1107311.Q767_07365	2.091e-08	64.0	28I7P@1|root,2Z8AJ@2|Bacteria,4NT89@976|Bacteroidetes,1IN1Q@117743|Flavobacteriia,2NX7V@237|Flavobacterium	976|Bacteroidetes	S	Protein of unknown function (DUF3800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3800
CMS2_k127_2076508_0	429009.Adeg_0304	8.512e-94	329.0	COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,42ENJ@68295|Thermoanaerobacterales	186801|Clostridia	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
CMS2_k127_2076508_1	756499.Desde_2888	7.422e-67	236.0	COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,261IU@186807|Peptococcaceae	186801|Clostridia	I	PFAM BadF BadG BcrA BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
CMS2_k127_2076508_3	647113.Metok_1545	1.775e-09	70.0	COG1775@1|root,arCOG04464@2157|Archaea,2XVHY@28890|Euryarchaeota,23QC0@183939|Methanococci	183939|Methanococci	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
CMS2_k127_2076508_5	398767.Glov_0091	5.465e-05	50.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42PEQ@68525|delta/epsilon subdivisions,2WKWX@28221|Deltaproteobacteria,43V9T@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
CMS2_k127_2078391_1	497964.CfE428DRAFT_4230	2.844e-40	154.0	COG3356@1|root,COG3356@2|Bacteria,46UC2@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
CMS2_k127_2078391_0	761193.Runsl_1895	3.111e-174	556.0	COG1520@1|root,COG1520@2|Bacteria,4NK4X@976|Bacteroidetes,47KWI@768503|Cytophagia	976|Bacteroidetes	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2078391_3	243164.DET1186	3.647e-18	94.0	COG0826@1|root,COG0826@2|Bacteria,2GAVB@200795|Chloroflexi,34DF3@301297|Dehalococcoidia	301297|Dehalococcoidia	O	peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2078391_2	1340493.JNIF01000003_gene3493	1.013e-19	100.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,DUF3857,TPR_16,TPR_8,Transglut_core
CMS2_k127_2078903_2	565033.GACE_0504	7.376e-07	54.0	COG0500@1|root,arCOG04347@2157|Archaea,2Y7Z9@28890|Euryarchaeota	28890|Euryarchaeota	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
CMS2_k127_2078903_3	426716.JOAJ01000003_gene3487	0.0008447	52.0	COG1807@1|root,COG1807@2|Bacteria,2GJPU@201174|Actinobacteria,4FTWD@85025|Nocardiaceae	201174|Actinobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS2_k127_2078903_0	269799.Gmet_2892	4.471e-109	362.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42MCE@68525|delta/epsilon subdivisions,2WIYP@28221|Deltaproteobacteria,43U7K@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
CMS2_k127_2078903_1	794903.OPIT5_06455	1.751e-52	190.0	COG1874@1|root,COG1874@2|Bacteria,46Y99@74201|Verrucomicrobia,3K95M@414999|Opitutae	414999|Opitutae	G	Domain of unknown function (DUF4832)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4832,Glyco_hydro_42
CMS2_k127_2084934_6	575540.Isop_0606	1.074e-44	167.0	COG1413@1|root,COG1413@2|Bacteria,2J0ZX@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_2084934_2	886379.AEWI01000007_gene828	9.777e-97	329.0	COG0025@1|root,COG0025@2|Bacteria,4PFE9@976|Bacteroidetes,2FX2R@200643|Bacteroidia,3XJI1@558415|Marinilabiliaceae	2|Bacteria	P	Sodium/hydrogen exchanger family	-	-	3.1.3.16	ko:K06382	-	-	-	-	ko00000,ko01000	-	-	-	Na_H_Exchanger
CMS2_k127_2084934_8	338963.Pcar_0560	6.18e-07	51.0	COG0025@1|root,COG0025@2|Bacteria,1QTW8@1224|Proteobacteria,42T9Y@68525|delta/epsilon subdivisions,2X7R0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
CMS2_k127_2084934_4	1123508.JH636444_gene5664	9.876e-67	234.0	COG0500@1|root,COG2226@2|Bacteria,2IZR2@203682|Planctomycetes	203682|Planctomycetes	Q	COG2226 Methylase involved in ubiquinone menaquinone biosynthesis	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
CMS2_k127_2084934_7	1123252.ATZF01000021_gene2980	4.429e-16	87.0	COG0454@1|root,COG0456@2|Bacteria,1W059@1239|Firmicutes,4I0J4@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2084934_5	697303.Thewi_1122	7.699e-48	192.0	COG2120@1|root,COG2120@2|Bacteria,1TQM2@1239|Firmicutes,24EYU@186801|Clostridia,42GI0@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PIG-L
CMS2_k127_2084934_1	1121403.AUCV01000017_gene4541	1.038e-138	457.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MHQQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS2_k127_2084934_3	1293054.HSACCH_01367	1.961e-69	245.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,3WA6D@53433|Halanaerobiales	186801|Clostridia	J	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
CMS2_k127_2084934_0	1142394.PSMK_26660	4.225e-218	693.0	COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,2IXPK@203682|Planctomycetes	203682|Planctomycetes	J	Ribosomal protein S1	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
CMS2_k127_2091353_0	517418.Ctha_1865	1.071e-42	173.0	COG5184@1|root,COG5492@1|root,COG5184@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,CHU_C,Calx-beta,ChW,Flg_new,Glug,Phage_TTP_12,RCC1
CMS2_k127_2100442_0	595460.RRSWK_04778	1.105e-48	201.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12,TPR_8
CMS2_k127_210075_7	693979.Bache_0230	3.816e-19	102.0	28KYZ@1|root,2ZAEB@2|Bacteria,4NHBZ@976|Bacteroidetes,2FP4X@200643|Bacteroidia,4AMVW@815|Bacteroidaceae	976|Bacteroidetes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_210075_3	1056820.KB900629_gene1727	1.163e-111	369.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,1RPNJ@1236|Gammaproteobacteria,2PMQB@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
CMS2_k127_210075_4	518766.Rmar_2279	2.158e-35	142.0	COG3090@1|root,COG3090@2|Bacteria,4NNRW@976|Bacteroidetes	976|Bacteroidetes	G	TRAP-type C4-dicarboxylate transport system small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
CMS2_k127_210075_2	1254432.SCE1572_20560	2.246e-155	501.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria	1224|Proteobacteria	G	TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
CMS2_k127_210075_0	595460.RRSWK_03283	4.063e-178	587.0	COG0531@1|root,COG0589@1|root,COG0531@2|Bacteria,COG0589@2|Bacteria,2J0UK@203682|Planctomycetes	203682|Planctomycetes	E	Amino acid permease	-	-	-	ko:K16238	-	-	-	-	ko00000,ko02000	2.A.3.5	-	-	AA_permease_2
CMS2_k127_210075_9	1444310.JANV01000096_gene3265	6.21e-05	48.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	DUF4369,Omp28
CMS2_k127_210075_5	1123371.ATXH01000001_gene1278	3.161e-28	119.0	COG0071@1|root,COG0071@2|Bacteria,2GHTW@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS2_k127_210075_8	357808.RoseRS_3392	4.27e-11	74.0	COG1413@1|root,COG1413@2|Bacteria,2G6UU@200795|Chloroflexi	200795|Chloroflexi	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS2_k127_210075_1	1408473.JHXO01000002_gene3787	2.183e-171	549.0	COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,2FNQB@200643|Bacteroidia	976|Bacteroidetes	G	pectate lyase K01728	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_210075_6	1123242.JH636434_gene3868	3.031e-27	117.0	COG1520@1|root,COG1520@2|Bacteria,2IYRB@203682|Planctomycetes	1123242.JH636434_gene3868|-	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2104220_2	1122239.AULS01000008_gene2431	3.138e-11	72.0	COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria	2|Bacteria	L	Transposase	tnp3514a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve
CMS2_k127_2104220_1	595460.RRSWK_03616	6.106e-87	303.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	DUF4976,Sulfatase
CMS2_k127_2104220_0	926549.KI421517_gene2473	1.555e-99	334.0	COG3669@1|root,COG3669@2|Bacteria,4NEAP@976|Bacteroidetes,47PH6@768503|Cytophagia	976|Bacteroidetes	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Fucosidase_C
CMS2_k127_2130095_7	247490.KSU1_C1324	9.465e-17	89.0	COG1957@1|root,COG3055@1|root,COG3204@1|root,COG4932@1|root,COG1957@2|Bacteria,COG3055@2|Bacteria,COG3204@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K02674,ko:K07004	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	DUF547,Laminin_G_3,Malectin
CMS2_k127_2130095_6	497964.CfE428DRAFT_4835	3.385e-19	94.0	COG4747@1|root,COG4747@2|Bacteria,46WIS@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
CMS2_k127_2130095_8	1266998.ATUJ01000009_gene528	7.556e-06	53.0	COG1366@1|root,COG1366@2|Bacteria,1PTSS@1224|Proteobacteria,2VAK7@28211|Alphaproteobacteria,2PYZG@265|Paracoccus	28211|Alphaproteobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS
CMS2_k127_2130095_2	1396141.BATP01000030_gene3715	2.569e-147	509.0	COG2010@1|root,COG2312@1|root,COG5337@1|root,COG5563@1|root,COG2010@2|Bacteria,COG2312@2|Bacteria,COG5337@2|Bacteria,COG5563@2|Bacteria,46XD5@74201|Verrucomicrobia,2IVHX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Fn3_assoc,LTD
CMS2_k127_2130095_3	595460.RRSWK_03118	1.598e-52	197.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_2130095_0	204669.Acid345_2578	2.482e-192	640.0	COG0412@1|root,COG0515@1|root,COG1262@1|root,COG0412@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	57723|Acidobacteria	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_2130095_4	489825.LYNGBM3L_01100	4.741e-45	179.0	COG0398@1|root,COG0398@2|Bacteria,1G3R9@1117|Cyanobacteria,1H8VH@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
CMS2_k127_2130095_1	269799.Gmet_1290	1.039e-162	520.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,43TWM@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
CMS2_k127_2130095_5	349161.Dred_2286	1.38e-23	107.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,262RV@186807|Peptococcaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_2133581_2	192952.MM_2938	2.959e-16	93.0	COG3291@1|root,COG5563@1|root,arCOG03501@2157|Archaea,arCOG03504@2157|Archaea	2157|Archaea	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Disaggr_assoc
CMS2_k127_2133581_1	1122925.KB895401_gene95	3.563e-47	190.0	COG2866@1|root,COG3210@1|root,COG3507@1|root,COG2866@2|Bacteria,COG3210@2|Bacteria,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_4,DUF1349,Flg_new,Glyco_hydro_43,LRR_5,Laminin_G_3,SLH
CMS2_k127_2133581_0	1379698.RBG1_1C00001G0607	1.319e-146	494.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
CMS2_k127_2133581_3	266834.SM_b20592	0.0009594	44.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U182@28211|Alphaproteobacteria,4BC79@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_2137777_0	1121405.dsmv_3003	0.0	1480.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	glycosyltransferase 36 associated	-	-	2.4.1.20	ko:K00702,ko:K13688	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
CMS2_k127_2147281_1	1232410.KI421421_gene3328	4.925e-139	447.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,43S64@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4070)	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_2147281_0	335543.Sfum_1119	2.803e-223	707.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MQVC@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Cation transporter/ATPase, N-terminus	ctpF	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
CMS2_k127_2166556_4	1250005.PHEL85_0454	2.621e-18	101.0	COG1404@1|root,COG2312@1|root,COG4935@1|root,COG1404@2|Bacteria,COG2312@2|Bacteria,COG4935@2|Bacteria,4NH8G@976|Bacteroidetes,1HYKE@117743|Flavobacteriia,3VX3A@52959|Polaribacter	976|Bacteroidetes	O	CotH kinase protein	cotH	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,LTD,P_proprotein
CMS2_k127_2166556_0	1396141.BATP01000006_gene5432	7.065e-273	871.0	COG2312@1|root,COG2885@1|root,COG3209@1|root,COG3210@1|root,COG2312@2|Bacteria,COG2885@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,46XSC@74201|Verrucomicrobia,2IWGQ@203494|Verrucomicrobiae	2|Bacteria	M	CotH kinase protein	-	-	-	ko:K02487,ko:K12543	ko02020,map02020	M00330,M00507	-	-	ko00000,ko00001,ko00002,ko02000,ko02022,ko02035,ko02044	1.B.17,3.A.1.109.4	-	-	CotH,Erythro_esteras,LTD,OmpA
CMS2_k127_2166556_6	1396141.BATP01000056_gene3278	1.512e-10	75.0	COG0028@1|root,COG3055@1|root,COG3209@1|root,COG4625@1|root,COG4932@1|root,COG0028@2|Bacteria,COG3055@2|Bacteria,COG3209@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	4.1.3.1	ko:K01637,ko:K20276	ko00630,ko01100,ko01110,ko01120,ko01200,ko02024,map00630,map01100,map01110,map01120,map01200,map02024	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	He_PIG,Laminin_G_3,Malectin
CMS2_k127_2166556_5	1121101.HMPREF1532_00978	1.062e-15	92.0	COG3119@1|root,COG3866@1|root,COG3119@2|Bacteria,COG3866@2|Bacteria,4NJUK@976|Bacteroidetes,2FR5P@200643|Bacteroidia,4ATC8@815|Bacteroidaceae	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2166556_8	661478.OP10G_3810	1.057e-06	59.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02650,ko:K02679	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	N_methyl,SBP_bac_10
CMS2_k127_2166556_3	761193.Runsl_2560	5.91e-100	336.0	COG3828@1|root,COG3828@2|Bacteria,4PNCT@976|Bacteroidetes,47NTF@768503|Cytophagia	976|Bacteroidetes	S	Methane oxygenase PmoA	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
CMS2_k127_2166556_1	452637.Oter_1159	9.221e-149	501.0	COG3867@1|root,COG3867@2|Bacteria,46VSS@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM glycosyl hydrolase 53 domain protein	-	-	3.2.1.89	ko:K01224	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_53
CMS2_k127_2166556_2	700598.Niako_3112	7.728e-113	395.0	COG4733@1|root,COG4733@2|Bacteria,4PNJC@976|Bacteroidetes,1IUZT@117747|Sphingobacteriia	976|Bacteroidetes	S	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase,Laminin_G_3,fn3
CMS2_k127_2166556_7	59374.Fisuc_2002	5.664e-10	73.0	COG3866@1|root,COG4733@1|root,COG3866@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Laminin_G_3,fn3
CMS2_k127_2166556_9	459349.CLOAM0895	6.864e-06	59.0	COG1361@1|root,COG1404@1|root,COG4412@1|root,COG1361@2|Bacteria,COG1404@2|Bacteria,COG4412@2|Bacteria,2NREM@2323|unclassified Bacteria	2|Bacteria	O	Evidence 5 No homology to any previously reported sequences	-	-	3.4.17.22	ko:K07752	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Calx-beta,DUF4859,FlgD_ig,VCBS
CMS2_k127_2179244_9	756272.Plabr_0707	1.373e-07	56.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,TPR_8
CMS2_k127_2179244_1	502025.Hoch_0991	2.4e-99	335.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,4313Z@68525|delta/epsilon subdivisions,2WX2K@28221|Deltaproteobacteria,2Z2QP@29|Myxococcales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
CMS2_k127_2179244_5	1380390.JIAT01000011_gene2883	8.469e-12	78.0	COG0028@1|root,COG0515@1|root,COG1409@1|root,COG1749@1|root,COG2374@1|root,COG3291@1|root,COG3509@1|root,COG4733@1|root,COG0028@2|Bacteria,COG0515@2|Bacteria,COG1409@2|Bacteria,COG1749@2|Bacteria,COG2374@2|Bacteria,COG3291@2|Bacteria,COG3509@2|Bacteria,COG4733@2|Bacteria,2I2X3@201174|Actinobacteria,4CSIX@84995|Rubrobacteria	84995|Rubrobacteria	N	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,fn3
CMS2_k127_2179244_4	1303518.CCALI_01222	1.676e-13	81.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_2179244_0	1396141.BATP01000057_gene3053	1.185e-104	381.0	COG2312@1|root,COG3209@1|root,COG2312@2|Bacteria,COG3209@2|Bacteria,46XD5@74201|Verrucomicrobia,2IVHX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Fn3_assoc,LTD
CMS2_k127_2179244_7	398512.JQKC01000022_gene3644	2.892e-10	75.0	COG5337@1|root,COG5337@2|Bacteria	2|Bacteria	M	Spore coat protein CotH	-	-	-	-	-	-	-	-	-	-	-	-	CotH,Fn3_assoc,LTD
CMS2_k127_2179244_6	446462.Amir_2750	5.549e-11	77.0	COG3209@1|root,COG3209@2|Bacteria,2GP7Z@201174|Actinobacteria,4DXWA@85010|Pseudonocardiales	201174|Actinobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PA14,RHS_repeat
CMS2_k127_2179244_8	243090.RB11055	6.044e-08	61.0	COG1957@1|root,COG4409@1|root,COG1957@2|Bacteria,COG4409@2|Bacteria,2IXPZ@203682|Planctomycetes	203682|Planctomycetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
CMS2_k127_2179244_2	1449350.OCH239_13000	5.811e-43	178.0	COG2755@1|root,COG3087@1|root,COG3291@1|root,COG2755@2|Bacteria,COG3087@2|Bacteria,COG3291@2|Bacteria,1R8SK@1224|Proteobacteria,2UNN5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	G8	-	-	-	-	-	-	-	-	-	-	-	-	G8
CMS2_k127_2179244_10	401053.AciPR4_1212	3.245e-05	54.0	COG3303@1|root,COG3303@2|Bacteria,3Y999@57723|Acidobacteria,2JP5G@204432|Acidobacteriia	204432|Acidobacteriia	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS2_k127_2179244_3	1450694.BTS2_0048	2.44e-17	94.0	COG0667@1|root,COG0667@2|Bacteria,1TPIY@1239|Firmicutes,4HA4Q@91061|Bacilli,1ZCES@1386|Bacillus	91061|Bacilli	C	Aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS2_k127_2182779_1	344747.PM8797T_30434	8e-50	186.0	COG1914@1|root,COG1914@2|Bacteria,2IYDP@203682|Planctomycetes	203682|Planctomycetes	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
CMS2_k127_2182779_0	632335.Calkr_0337	1.272e-234	741.0	COG1274@1|root,COG1274@2|Bacteria,1TQED@1239|Firmicutes,249NP@186801|Clostridia,42FYF@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
CMS2_k127_2182779_3	329726.AM1_2826	1.133e-32	138.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	yprA	-	3.4.11.19	ko:K01266,ko:K07052	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Abi
CMS2_k127_2182779_2	439235.Dalk_3988	2.418e-49	181.0	COG3809@1|root,COG3809@2|Bacteria,1QSA6@1224|Proteobacteria	1224|Proteobacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
CMS2_k127_2182779_5	517418.Ctha_1539	2.354e-05	48.0	COG5184@1|root,COG5492@1|root,COG5184@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Cadherin-like,Glug
CMS2_k127_2186326_11	237368.SCABRO_02952	3.413e-10	61.0	COG3808@1|root,COG3808@2|Bacteria,2IXUH@203682|Planctomycetes	203682|Planctomycetes	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K01507,ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
CMS2_k127_2186326_8	1142394.PSMK_02820	1.638e-35	139.0	COG0799@1|root,COG0799@2|Bacteria,2J0AM@203682|Planctomycetes	203682|Planctomycetes	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
CMS2_k127_2186326_1	1173025.GEI7407_0211	4.598e-158	521.0	COG0018@1|root,COG0018@2|Bacteria,1G15V@1117|Cyanobacteria,1H7AH@1150|Oscillatoriales	1117|Cyanobacteria	J	Arginyl tRNA synthetase N terminal domain	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
CMS2_k127_2186326_10	324602.Caur_2099	1.813e-26	111.0	COG1669@1|root,COG1669@2|Bacteria,2G76P@200795|Chloroflexi	200795|Chloroflexi	L	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
CMS2_k127_2186326_6	1395587.P364_0106345	3.031e-46	172.0	COG0432@1|root,COG0432@2|Bacteria,1V6J7@1239|Firmicutes,4HHV7@91061|Bacilli,26WXC@186822|Paenibacillaceae	91061|Bacilli	S	Uncharacterised protein family UPF0047	yugU	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CMS2_k127_2186326_3	1142394.PSMK_29570	3.448e-59	213.0	COG0325@1|root,COG0325@2|Bacteria,2IZ9R@203682|Planctomycetes	203682|Planctomycetes	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
CMS2_k127_2186326_7	1142394.PSMK_18360	5.459e-42	173.0	COG2208@1|root,COG2208@2|Bacteria,2J0ZD@203682|Planctomycetes	203682|Planctomycetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
CMS2_k127_2186326_5	697281.Mahau_2175	3.089e-47	177.0	COG1351@1|root,COG1351@2|Bacteria,1TRAA@1239|Firmicutes,249DJ@186801|Clostridia,42G34@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
CMS2_k127_2186326_0	56780.SYN_00176	7.223e-196	629.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1NPFY@1224|Proteobacteria,42PRW@68525|delta/epsilon subdivisions,2WIMG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	homocysteine S-methyltransferase	metF-2	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0504	MTHFR,S-methyl_trans
CMS2_k127_2186326_2	247490.KSU1_C0507	1.55e-108	373.0	COG1361@1|root,COG1361@2|Bacteria,2IY9X@203682|Planctomycetes	203682|Planctomycetes	M	60 kDa outer membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
CMS2_k127_2186326_9	1356854.N007_03705	1.244e-32	132.0	COG0511@1|root,COG0511@2|Bacteria,1VAB7@1239|Firmicutes,4HKCS@91061|Bacilli,279UX@186823|Alicyclobacillaceae	91061|Bacilli	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
CMS2_k127_2186326_4	1267535.KB906767_gene4313	1.462e-51	184.0	COG0439@1|root,COG0439@2|Bacteria,3Y2QZ@57723|Acidobacteria,2JIFS@204432|Acidobacteriia	204432|Acidobacteriia	I	acetyl-CoA carboxylase, biotin carboxylase	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
CMS2_k127_2194806_5	1182590.BN5_02144	1.759e-20	98.0	COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1SASQ@1236|Gammaproteobacteria,1YCT8@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_2194806_6	192952.MM_1144	4.472e-15	89.0	COG5563@1|root,arCOG03499@1|root,arCOG03499@2157|Archaea,arCOG03501@2157|Archaea	2157|Archaea	S	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Disaggr_assoc,Disaggr_repeat,PKD
CMS2_k127_2194806_10	457570.Nther_0354	9.024e-07	62.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Beta_helix
CMS2_k127_2194806_7	1121373.KB903664_gene2604	1.28e-10	75.0	COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NHCE@976|Bacteroidetes,47NZ4@768503|Cytophagia	976|Bacteroidetes	MU	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40
CMS2_k127_2194806_2	395961.Cyan7425_1325	1.059e-51	192.0	COG2242@1|root,COG2242@2|Bacteria	2|Bacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
CMS2_k127_2194806_9	478741.JAFS01000001_gene1111	4.025e-07	62.0	COG0392@1|root,COG0392@2|Bacteria,46YYT@74201|Verrucomicrobia,37GP8@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS2_k127_2194806_4	383372.Rcas_0756	3.986e-22	106.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.294,2.1.1.64,2.7.1.181	ko:K00568,ko:K18827	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781,R10657,R10658	RC00002,RC00003,RC00078,RC00392,RC01895,RC03220	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS2_k127_2194806_8	550540.Fbal_2276	1.52e-08	66.0	COG0500@1|root,COG0500@2|Bacteria,1QUI2@1224|Proteobacteria,1RQ53@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	SAM-dependent methyltransferase	bioC_2	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS2_k127_2194806_0	596152.DesU5LDRAFT_2110	1.236e-83	290.0	COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,42PK2@68525|delta/epsilon subdivisions,2WP9Y@28221|Deltaproteobacteria,2M89Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_2194806_1	1089551.KE386572_gene399	7.71e-67	247.0	COG0438@1|root,COG0438@2|Bacteria,1RH5W@1224|Proteobacteria,2V854@28211|Alphaproteobacteria,4BSTB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
CMS2_k127_2194806_3	479434.Sthe_0853	7.722e-25	111.0	COG0500@1|root,COG2226@2|Bacteria,2G780@200795|Chloroflexi,27XGX@189775|Thermomicrobia	189775|Thermomicrobia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_2223037_9	1123277.KB893172_gene1010	2.363e-07	64.0	COG3210@1|root,COG3210@2|Bacteria,4NYAH@976|Bacteroidetes,47VEP@768503|Cytophagia	976|Bacteroidetes	U	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2223037_10	1296416.JACB01000057_gene1504	0.0002336	55.0	COG1470@1|root,COG3342@1|root,COG1470@2|Bacteria,COG3342@2|Bacteria,4PM83@976|Bacteroidetes,1IJM6@117743|Flavobacteriia,2YM75@290174|Aquimarina	976|Bacteroidetes	S	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	MAM,Reprolysin_4,Reprolysin_5,fn3
CMS2_k127_2223037_2	203119.Cthe_0732	9.293e-73	261.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,3WG94@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
CMS2_k127_2223037_4	179408.Osc7112_4977	5.939e-34	135.0	2CCSR@1|root,32RWC@2|Bacteria,1GA04@1117|Cyanobacteria,1HDA0@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
CMS2_k127_2223037_1	398512.JQKC01000002_gene1952	1.153e-113	384.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,3WG99@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
CMS2_k127_2223037_5	56110.Oscil6304_1666	2.052e-31	125.0	COG3668@1|root,COG3668@2|Bacteria,1G8WD@1117|Cyanobacteria,1HDM2@1150|Oscillatoriales	1117|Cyanobacteria	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
CMS2_k127_2223037_6	82654.Pse7367_3904	5.415e-14	74.0	2E9VI@1|root,3341D@2|Bacteria,1GRB3@1117|Cyanobacteria	1117|Cyanobacteria	S	Addiction module component, TIGR02574 family	-	-	-	-	-	-	-	-	-	-	-	-	Unstab_antitox
CMS2_k127_2223037_8	509635.N824_16365	4.468e-10	68.0	28NR7@1|root,2ZBQI@2|Bacteria,4NMCH@976|Bacteroidetes,1ISEX@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2223037_0	886293.Sinac_3037	3.303e-116	383.0	COG0540@1|root,COG0540@2|Bacteria,2IXJB@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS2_k127_2223037_3	243164.DET1198	5.247e-49	180.0	COG2065@1|root,COG2065@2|Bacteria,2G6WS@200795|Chloroflexi,34D9M@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	GO:0003674,GO:0003700,GO:0003824,GO:0004845,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
CMS2_k127_2223037_7	583355.Caka_2221	1.773e-10	73.0	COG1404@1|root,COG1404@2|Bacteria,46WMI@74201|Verrucomicrobia,3K9SW@414999|Opitutae	414999|Opitutae	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2225538_1	518766.Rmar_1740	3.327e-80	278.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,1FK20@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_2225538_0	518766.Rmar_1740	3.089e-121	404.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,1FK20@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_2225538_2	459349.CLOAM0193	9.842e-33	146.0	COG4886@1|root,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	COR,LRR_4,LRR_6,LRR_8,Roc
CMS2_k127_2225538_3	1034769.KB910518_gene1041	1.673e-17	97.0	COG1621@1|root,COG3204@1|root,COG3533@1|root,COG3940@1|root,COG1621@2|Bacteria,COG3204@2|Bacteria,COG3533@2|Bacteria,COG3940@2|Bacteria,1U157@1239|Firmicutes,4HT9T@91061|Bacilli,26UV2@186822|Paenibacillaceae	91061|Bacilli	G	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,Laminin_G_3
CMS2_k127_2238285_6	880070.Cycma_0727	4.108e-07	57.0	COG3055@1|root,COG3055@2|Bacteria,4NHHD@976|Bacteroidetes,47K9E@768503|Cytophagia	976|Bacteroidetes	S	Kelch repeat	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Kelch_1,Kelch_4,Kelch_6,Malectin,PKD
CMS2_k127_2238285_7	357808.RoseRS_1736	2.598e-06	60.0	COG1413@1|root,COG1674@1|root,COG5635@1|root,COG1413@2|Bacteria,COG1674@2|Bacteria,COG5635@2|Bacteria,2G8R0@200795|Chloroflexi,3766B@32061|Chloroflexia	32061|Chloroflexia	CDT	Armadillo/beta-catenin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS2_k127_2238285_0	886293.Sinac_5251	2.313e-176	574.0	COG1199@1|root,COG1199@2|Bacteria,2IX82@203682|Planctomycetes	203682|Planctomycetes	KL	helicase	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
CMS2_k127_2238285_4	1433126.BN938_0782	3.024e-66	245.0	COG1520@1|root,COG1520@2|Bacteria,4P28I@976|Bacteroidetes,2FX0J@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_2238285_5	177439.DP1039	2.957e-13	74.0	COG0401@1|root,COG0401@2|Bacteria,1N7K3@1224|Proteobacteria,42V3U@68525|delta/epsilon subdivisions,2WRBV@28221|Deltaproteobacteria,2MKUH@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Proteolipid membrane potential modulator	-	-	-	-	-	-	-	-	-	-	-	-	Pmp3
CMS2_k127_2238285_2	1319815.HMPREF0202_01111	9.276e-114	387.0	COG0475@1|root,COG1762@1|root,COG0475@2|Bacteria,COG1762@2|Bacteria,37CPG@32066|Fusobacteria	32066|Fusobacteria	GPT	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2
CMS2_k127_2238285_3	56780.SYN_02176	1.055e-82	290.0	COG1032@1|root,COG1032@2|Bacteria,1R4XI@1224|Proteobacteria,42NPM@68525|delta/epsilon subdivisions,2WJK2@28221|Deltaproteobacteria,2MQ6Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_2238285_1	583355.Caka_3109	2.086e-123	414.0	COG2312@1|root,COG3507@1|root,COG2312@2|Bacteria,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	1.16.3.3	ko:K22350	-	-	-	-	ko00000,ko01000	-	-	-	Big_2,Big_4,CBM_6,DUF1080,DUF1349,Erythro_esteras,GSDH,Glyco_hydro_43,LTD,Laminin_G_3,PKD,SLH
CMS2_k127_224299_0	530564.Psta_2900	3.211e-199	642.0	COG3119@1|root,COG3119@2|Bacteria,2IYFZ@203682|Planctomycetes	203682|Planctomycetes	CP	COG3119 Arylsulfatase A	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	HEAT_2,Sulfatase
CMS2_k127_224299_2	1123508.JH636439_gene1349	5.498e-13	83.0	COG2982@1|root,COG2982@2|Bacteria,2IYVI@203682|Planctomycetes	203682|Planctomycetes	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
CMS2_k127_224299_1	1125863.JAFN01000001_gene568	8.998e-141	462.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC,GARS_A,GARS_C,GARS_N
CMS2_k127_2249299_1	1195236.CTER_4883	5.426e-69	248.0	COG2006@1|root,COG2006@2|Bacteria,1VRZ8@1239|Firmicutes,24Z9V@186801|Clostridia,3WN5G@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Dockerin_1
CMS2_k127_2249299_0	1210884.HG799472_gene14865	1.794e-79	276.0	COG1131@1|root,COG1131@2|Bacteria,2J2ET@203682|Planctomycetes	203682|Planctomycetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS2_k127_2249299_2	1210884.HG799472_gene14864	5.271e-07	61.0	2EWXF@1|root,33Q8U@2|Bacteria,2J2GJ@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2292143_1	886293.Sinac_0501	0.0	1013.0	COG0085@1|root,COG0085@2|Bacteria,2IXVZ@203682|Planctomycetes	203682|Planctomycetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
CMS2_k127_2292143_0	886293.Sinac_0499	0.0	1833.0	COG0086@1|root,COG0086@2|Bacteria,2IXGN@203682|Planctomycetes	203682|Planctomycetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
CMS2_k127_2292143_16	373903.Hore_01120	1.586e-51	184.0	COG0048@1|root,COG0048@2|Bacteria,1V1FJ@1239|Firmicutes,24FQT@186801|Clostridia,3WANZ@53433|Halanaerobiales	186801|Clostridia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
CMS2_k127_2292143_11	344747.PM8797T_12183	2.433e-62	217.0	COG0049@1|root,COG0049@2|Bacteria,2IZ7I@203682|Planctomycetes	203682|Planctomycetes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
CMS2_k127_2292143_2	289376.THEYE_A1449	1.515e-231	736.0	COG0480@1|root,COG0480@2|Bacteria,3J0EK@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS2_k127_2292143_19	1142394.PSMK_29190	3.943e-45	167.0	COG0051@1|root,COG0051@2|Bacteria,2IZQR@203682|Planctomycetes	203682|Planctomycetes	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
CMS2_k127_2292143_12	561175.KB894099_gene5133	4.277e-61	218.0	COG0087@1|root,COG0087@2|Bacteria,2GJXT@201174|Actinobacteria,4EIEQ@85012|Streptosporangiales	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
CMS2_k127_2292143_18	344747.PM8797T_12203	4.736e-48	180.0	COG0088@1|root,COG0088@2|Bacteria,2IYU2@203682|Planctomycetes	203682|Planctomycetes	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
CMS2_k127_2292143_32	530564.Psta_2602	1.065e-18	90.0	COG0089@1|root,COG0089@2|Bacteria,2J0VE@203682|Planctomycetes	203682|Planctomycetes	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
CMS2_k127_2292143_5	756272.Plabr_2060	1.172e-113	373.0	COG0090@1|root,COG0090@2|Bacteria,2IXD9@203682|Planctomycetes	203682|Planctomycetes	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
CMS2_k127_2292143_25	295358.mhp191	2.419e-32	133.0	COG0185@1|root,COG0185@2|Bacteria,3WTPD@544448|Tenericutes	544448|Tenericutes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
CMS2_k127_2292143_34	1121441.AUCX01000018_gene1511	1.392e-13	78.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2WQBH@28221|Deltaproteobacteria,2MBW5@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
CMS2_k127_2292143_7	1142394.PSMK_29120	2.613e-73	255.0	COG0092@1|root,COG0092@2|Bacteria,2IWWU@203682|Planctomycetes	203682|Planctomycetes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
CMS2_k127_2292143_13	697303.Thewi_2248	1.567e-55	197.0	COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,42G0F@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
CMS2_k127_2292143_35	521674.Plim_0485	6.808e-07	53.0	COG0255@1|root,COG0255@2|Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
CMS2_k127_2292143_30	1453496.AT03_20250	9.584e-25	108.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
CMS2_k127_2292143_21	1142394.PSMK_29080	1.072e-41	160.0	COG0093@1|root,COG0093@2|Bacteria,2IZMA@203682|Planctomycetes	203682|Planctomycetes	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
CMS2_k127_2292143_28	941639.BCO26_0130	2.264e-28	117.0	COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,4HKH9@91061|Bacilli,1ZGZQ@1386|Bacillus	91061|Bacilli	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
CMS2_k127_2292143_9	515622.bpr_I0606	1.647e-68	238.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,247X0@186801|Clostridia,4BYIQ@830|Butyrivibrio	186801|Clostridia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
CMS2_k127_2292143_31	1229783.C273_03900	4.979e-21	95.0	COG0199@1|root,COG0199@2|Bacteria,1VEF6@1239|Firmicutes,4HNKX@91061|Bacilli,4GZMV@90964|Staphylococcaceae	91061|Bacilli	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
CMS2_k127_2292143_22	1035196.HMPREF9998_00678	4.198e-40	158.0	COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,24HCP@186801|Clostridia,25RBC@186804|Peptostreptococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
CMS2_k127_2292143_14	247490.KSU1_C1223	4.562e-52	190.0	COG0097@1|root,COG0097@2|Bacteria,2IZ8X@203682|Planctomycetes	203682|Planctomycetes	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
CMS2_k127_2292143_24	760568.Desku_3041	6.378e-36	141.0	COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,24JCS@186801|Clostridia,2627U@186807|Peptococcaceae	186801|Clostridia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
CMS2_k127_2292143_17	575540.Isop_2097	1.065e-50	184.0	COG0098@1|root,COG0098@2|Bacteria,2IZ7J@203682|Planctomycetes	203682|Planctomycetes	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
CMS2_k127_2292143_23	1131462.DCF50_p1880	4.855e-36	141.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia,261YE@186807|Peptococcaceae	186801|Clostridia	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
CMS2_k127_2292143_3	756272.Plabr_2075	5.002e-134	441.0	COG0201@1|root,COG0201@2|Bacteria,2IXN6@203682|Planctomycetes	203682|Planctomycetes	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
CMS2_k127_2292143_10	1118057.CAGX01000039_gene1949	1.799e-63	224.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,22HA7@1570339|Peptoniphilaceae	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
CMS2_k127_2292143_6	575540.Isop_2067	2.717e-75	262.0	COG0024@1|root,COG0024@2|Bacteria,2IXPX@203682|Planctomycetes	203682|Planctomycetes	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
CMS2_k127_2292143_26	941824.TCEL_01083	1.423e-31	124.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,24MQE@186801|Clostridia,36KM7@31979|Clostridiaceae	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
CMS2_k127_2292143_33	247490.KSU1_C1231	1.187e-13	70.0	COG0257@1|root,COG0257@2|Bacteria,2J1IK@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
CMS2_k127_2292143_20	756272.Plabr_2079	5.867e-42	158.0	COG0099@1|root,COG0099@2|Bacteria,2IZK8@203682|Planctomycetes	203682|Planctomycetes	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
CMS2_k127_2292143_15	1210884.HG799465_gene12004	5.666e-52	186.0	COG0100@1|root,COG0100@2|Bacteria,2IZCP@203682|Planctomycetes	203682|Planctomycetes	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
CMS2_k127_2292143_8	646529.Desaci_0517	1.722e-71	247.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,260U9@186807|Peptococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
CMS2_k127_2292143_4	1142394.PSMK_23760	7.242e-119	391.0	COG0202@1|root,COG0202@2|Bacteria,2IXPQ@203682|Planctomycetes	203682|Planctomycetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
CMS2_k127_2292143_29	880072.Desac_1427	9.563e-28	120.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,42SBD@68525|delta/epsilon subdivisions,2WP9P@28221|Deltaproteobacteria,2MQIR@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	PFAM ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
CMS2_k127_2292143_27	335543.Sfum_2848	7.998e-31	128.0	COG0537@1|root,COG0537@2|Bacteria,1PDTP@1224|Proteobacteria,42UAD@68525|delta/epsilon subdivisions,2WQRN@28221|Deltaproteobacteria,2MS5I@213462|Syntrophobacterales	28221|Deltaproteobacteria	FG	PFAM Histidine triad (HIT) protein	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
CMS2_k127_2292143_36	1229780.BN381_130143	0.0001407	48.0	2DREZ@1|root,33BFB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2308576_11	1287488.HMPREF0671_09555	3.265e-06	58.0	COG3118@1|root,COG3118@2|Bacteria,4NQNX@976|Bacteroidetes	976|Bacteroidetes	O	Thioredoxin	trxA2	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
CMS2_k127_2308576_7	404589.Anae109_3645	1.128e-27	128.0	COG0526@1|root,COG0526@2|Bacteria,1N0R9@1224|Proteobacteria,42UD9@68525|delta/epsilon subdivisions,2WQ0H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CO	PFAM Thioredoxin	trx-2	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS2_k127_2308576_4	1304885.AUEY01000001_gene3205	1.104e-41	156.0	COG4273@1|root,COG4273@2|Bacteria,1MZED@1224|Proteobacteria,42UH2@68525|delta/epsilon subdivisions,2WQNQ@28221|Deltaproteobacteria,2MM8A@213118|Desulfobacterales	28221|Deltaproteobacteria	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
CMS2_k127_2308576_5	1499967.BAYZ01000050_gene2842	4.49e-29	117.0	COG0526@1|root,COG0526@2|Bacteria,2NQ71@2323|unclassified Bacteria	2|Bacteria	CO	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4369,Thioredoxin_3
CMS2_k127_2308576_0	1047013.AQSP01000092_gene327	1.7e-162	522.0	COG0701@1|root,COG0701@2|Bacteria,2NP6A@2323|unclassified Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
CMS2_k127_2308576_9	1089553.Tph_c19160	4.016e-24	108.0	COG0640@1|root,COG0640@2|Bacteria,1V6CU@1239|Firmicutes,24R9E@186801|Clostridia,42H4C@68295|Thermoanaerobacterales	186801|Clostridia	K	PFAM regulatory protein, ArsR	-	-	-	ko:K03892,ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
CMS2_k127_2308576_8	306281.AJLK01000058_gene1146	7.431e-26	108.0	COG1724@1|root,COG1724@2|Bacteria,1G9XW@1117|Cyanobacteria	1117|Cyanobacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
CMS2_k127_2308576_6	402777.KB235904_gene4656	6.532e-28	114.0	COG1598@1|root,COG1598@2|Bacteria,1G8YA@1117|Cyanobacteria,1HD7Z@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2308576_3	1121405.dsmv_3144	5.272e-53	201.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria,2MIFD@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
CMS2_k127_2308576_10	485913.Krac_5515	2.689e-08	65.0	COG0697@1|root,COG0697@2|Bacteria,2G7RS@200795|Chloroflexi	200795|Chloroflexi	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS2_k127_2308576_1	1454004.AW11_02435	1.339e-92	328.0	COG2311@1|root,COG2311@2|Bacteria,1R8CP@1224|Proteobacteria	1224|Proteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2308576_2	1167006.UWK_02409	1.788e-72	248.0	COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,42MSD@68525|delta/epsilon subdivisions,2WM9P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_2308791_10	1278307.KB906968_gene2032	6.835e-32	124.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SWYU@1236|Gammaproteobacteria,2QJ81@267894|Psychromonadaceae	1236|Gammaproteobacteria	K	Ribonuclease B OB domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CMS2_k127_2308791_1	1521187.JPIM01000031_gene1991	5.255e-224	718.0	COG0481@1|root,COG0481@2|Bacteria,2G5K2@200795|Chloroflexi,3757E@32061|Chloroflexia	32061|Chloroflexia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
CMS2_k127_2308791_6	370438.PTH_0874	5.068e-86	301.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,260TE@186807|Peptococcaceae	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS2_k127_2308791_3	472759.Nhal_0193	3.863e-110	383.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria,1WXFQ@135613|Chromatiales	135613|Chromatiales	G	PFAM Glucose Sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	GSDH
CMS2_k127_2308791_14	1173028.ANKO01000144_gene1478	1.216e-11	75.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10,Dala_Dala_lig_C,RLAN,RimK
CMS2_k127_2308791_8	1031711.RSPO_c03332	5.92e-61	224.0	2EE8E@1|root,3382W@2|Bacteria,1NKE3@1224|Proteobacteria,2VZZC@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2308791_0	290397.Adeh_1020	6.4e-323	1019.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42M0A@68525|delta/epsilon subdivisions,2WIQY@28221|Deltaproteobacteria,2YTUC@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787,ko:K15726	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.2,2.A.6.1.4	-	-	ACR_tran
CMS2_k127_2308791_7	290397.Adeh_1019	3.545e-74	267.0	COG0845@1|root,COG0845@2|Bacteria,1MX8W@1224|Proteobacteria,42SYF@68525|delta/epsilon subdivisions,2WPNQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
CMS2_k127_2308791_5	472759.Nhal_1652	3.8e-92	321.0	COG1538@1|root,COG1538@2|Bacteria,1NEZC@1224|Proteobacteria,1S1F9@1236|Gammaproteobacteria,1X1BJ@135613|Chromatiales	135613|Chromatiales	MU	PFAM Outer membrane efflux protein	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
CMS2_k127_2308791_11	1123242.JH636434_gene3194	2.89e-18	94.0	COG4886@1|root,COG4886@2|Bacteria,2IZ9D@203682|Planctomycetes	203682|Planctomycetes	S	Leucine Rich repeat	-	-	-	-	-	-	-	-	-	-	-	-	LRR_6
CMS2_k127_2308791_2	880072.Desac_2119	4.825e-126	409.0	COG1148@1|root,COG1148@2|Bacteria,1RB0H@1224|Proteobacteria,42QQV@68525|delta/epsilon subdivisions,2WN7E@28221|Deltaproteobacteria,2MRI3@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
CMS2_k127_2308791_15	886379.AEWI01000081_gene1970	7.173e-11	74.0	COG1082@1|root,COG2133@1|root,COG1082@2|Bacteria,COG2133@2|Bacteria,4NFKF@976|Bacteroidetes,2FRR2@200643|Bacteroidia,3XKQ3@558415|Marinilabiliaceae	976|Bacteroidetes	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_2308791_12	1235792.C808_03989	4.96e-16	90.0	COG1453@1|root,COG1453@2|Bacteria,1TPBG@1239|Firmicutes,2497N@186801|Clostridia,27JCG@186928|unclassified Lachnospiraceae	186801|Clostridia	S	4Fe-4S dicluster domain	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
CMS2_k127_2308791_9	886293.Sinac_4026	6.914e-59	209.0	COG1595@1|root,COG1595@2|Bacteria,2IZ8A@203682|Planctomycetes	203682|Planctomycetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_2308791_4	452637.Oter_4175	6.594e-99	329.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,46VB0@74201|Verrucomicrobia,3K8AK@414999|Opitutae	414999|Opitutae	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_2317451_1	1499967.BAYZ01000095_gene4060	5.051e-97	319.0	COG4806@1|root,COG4806@2|Bacteria	2|Bacteria	G	L-rhamnose isomerase activity	rhaA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008270,GO:0008740,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019324,GO:0022607,GO:0030145,GO:0030246,GO:0032991,GO:0033296,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046872,GO:0046914,GO:0048029,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901575	2.7.1.5,5.3.1.14	ko:K00848,ko:K01813	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R02437,R03014	RC00002,RC00017,RC00434	ko00000,ko00001,ko01000	-	-	iECIAI39_1322.ECIAI39_3092,iUMNK88_1353.UMNK88_4739	RhaA
CMS2_k127_2317451_0	382464.ABSI01000007_gene4164	2.6e-209	664.0	COG1457@1|root,COG1457@2|Bacteria,46TUH@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Belongs to the purine-cytosine permease (2.A.39) family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2317451_3	1382306.JNIM01000001_gene28	2.784e-78	287.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,2G8BR@200795|Chloroflexi	200795|Chloroflexi	IQ	TIGRFAM rhamnulose-1-phosphate aldolase alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II,adh_short_C2
CMS2_k127_2317451_4	243090.RB6432	8.571e-21	107.0	COG2010@1|root,COG2755@1|root,COG5297@1|root,COG2010@2|Bacteria,COG2755@2|Bacteria,COG5297@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase family 6	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Alginate_lyase2,Lipase_GDSL_2
CMS2_k127_2317451_2	452637.Oter_2946	6.526e-87	306.0	COG5512@1|root,COG5512@2|Bacteria	2|Bacteria	L	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	Collagen_bind_2,DUF4038,DUF5060,DUF721
CMS2_k127_2336049_8	351627.Csac_1956	3.85e-36	138.0	COG0423@1|root,COG0423@2|Bacteria,1TP94@1239|Firmicutes,248FB@186801|Clostridia,42F4M@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
CMS2_k127_2336049_7	304371.MCP_0732	8.299e-41	155.0	COG0432@1|root,arCOG04214@2157|Archaea,2XYW0@28890|Euryarchaeota,2N9WB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CMS2_k127_2336049_9	530564.Psta_1307	6.425e-21	108.0	COG1413@1|root,COG1706@1|root,COG1413@2|Bacteria,COG1706@2|Bacteria,2IY0C@203682|Planctomycetes	203682|Planctomycetes	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	-	-	-	-	-	-	-	-	-	-	-	-	FlgI,HEAT_2
CMS2_k127_2336049_0	1128398.Curi_c16270	1.407e-161	552.0	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia,267UY@186813|unclassified Clostridiales	186801|Clostridia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
CMS2_k127_2336049_4	1499967.BAYZ01000103_gene3758	2.346e-93	329.0	COG0457@1|root,COG0457@2|Bacteria	1499967.BAYZ01000103_gene3758|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2336049_5	1499967.BAYZ01000089_gene5011	4.008e-51	185.0	COG3708@1|root,COG3708@2|Bacteria	2|Bacteria	K	glyoxalase III activity	-	-	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	Cass2,GyrI-like,HTH_18
CMS2_k127_2336049_3	1123508.JH636442_gene3851	6.265e-97	331.0	COG0612@1|root,COG0612@2|Bacteria,2IY7Q@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_2336049_2	756272.Plabr_1963	4.728e-110	370.0	COG0612@1|root,COG0612@2|Bacteria,2IWSI@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_2336049_1	1235803.C825_02469	1.507e-138	454.0	COG3119@1|root,COG3119@2|Bacteria,4NE7S@976|Bacteroidetes,2FMTS@200643|Bacteroidia	976|Bacteroidetes	P	COG COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase
CMS2_k127_2336049_6	509191.AEDB02000022_gene2935	2.818e-50	188.0	COG2006@1|root,COG2006@2|Bacteria,1VRZ8@1239|Firmicutes,24Z9V@186801|Clostridia,3WN5G@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Dockerin_1
CMS2_k127_2349873_1	927658.AJUM01000007_gene2722	5.166e-56	219.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9
CMS2_k127_2349873_7	1454004.AW11_02435	1.819e-08	61.0	COG2311@1|root,COG2311@2|Bacteria,1R8CP@1224|Proteobacteria	1224|Proteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2349873_4	1137799.GZ78_12955	3.314e-27	130.0	COG2911@1|root,COG2931@1|root,COG3533@1|root,COG5276@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3533@2|Bacteria,COG5276@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,He_PIG,OmpA_membrane,fn3
CMS2_k127_2349873_8	59374.Fisuc_2002	2.217e-06	62.0	COG3866@1|root,COG4733@1|root,COG3866@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Laminin_G_3,fn3
CMS2_k127_2349873_6	1122927.KB895431_gene78	6.837e-09	70.0	COG0383@1|root,COG2120@1|root,COG3210@1|root,COG4099@1|root,COG4733@1|root,COG5184@1|root,COG5276@1|root,COG0383@2|Bacteria,COG2120@2|Bacteria,COG3210@2|Bacteria,COG4099@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	3.2.1.24,3.4.24.40	ko:K01191,ko:K01406,ko:K20276	ko00511,ko01503,ko02024,map00511,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04131	-	GH38	-	Big_2,Cohesin,F5_F8_type_C,PIG-L,RCC1_2
CMS2_k127_2349873_9	1453505.JASY01000006_gene1259	6.03e-05	57.0	COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,1I0G9@117743|Flavobacteriia,2NTFA@237|Flavobacterium	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2349873_2	497964.CfE428DRAFT_5014	1.214e-34	155.0	COG2304@1|root,COG3055@1|root,COG3119@1|root,COG3291@1|root,COG2304@2|Bacteria,COG3055@2|Bacteria,COG3119@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	rapB1	-	3.2.1.4	ko:K01179,ko:K07004,ko:K12548	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Laminin_G_3
CMS2_k127_2349873_5	459349.CLOAM0567	1.071e-09	72.0	COG4412@1|root,COG4412@2|Bacteria,2NRKS@2323|unclassified Bacteria	2|Bacteria	M	Evidence 5 No homology to any previously reported sequences	-	-	3.4.21.50	ko:K01337,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	ASH,CarboxypepD_reg,Cleaved_Adhesin,DUF4968,DUF5110,F5_F8_type_C,FlgD_ig,Glyco_hydro_31,PA,Peptidase_M6,Peptidase_S8,W_rich_C
CMS2_k127_2349873_3	1121904.ARBP01000025_gene6084	8.131e-31	142.0	COG1404@1|root,COG2273@1|root,COG2730@1|root,COG2911@1|root,COG4733@1|root,COG1404@2|Bacteria,COG2273@2|Bacteria,COG2730@2|Bacteria,COG2911@2|Bacteria,COG4733@2|Bacteria,4NHHA@976|Bacteroidetes,47XBX@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,CHU_C,Calx-beta,He_PIG,NHL,TIG,fn3
CMS2_k127_2349873_0	452637.Oter_4336	2.178e-175	561.0	COG3534@1|root,COG3534@2|Bacteria,46UU3@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
CMS2_k127_238470_3	497964.CfE428DRAFT_4485	2.749e-35	136.0	COG0673@1|root,COG0673@2|Bacteria,46TM9@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_238470_0	545695.TREAZ_2513	4.247e-118	400.0	COG2730@1|root,COG2730@2|Bacteria,2J89M@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase
CMS2_k127_238470_1	509191.AEDB02000003_gene999	5.712e-98	328.0	COG0730@1|root,COG0730@2|Bacteria,1TPMA@1239|Firmicutes,25CI8@186801|Clostridia,3WJ6E@541000|Ruminococcaceae	186801|Clostridia	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS2_k127_238470_2	448385.sce4876	2.489e-37	151.0	COG1848@1|root,COG1848@2|Bacteria,1RFYN@1224|Proteobacteria,43015@68525|delta/epsilon subdivisions,2WV6Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_238470_4	398512.JQKC01000005_gene5590	6.819e-24	101.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,24819@186801|Clostridia,3WGNT@541000|Ruminococcaceae	186801|Clostridia	EF	Belongs to the CarB family	carB2	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
CMS2_k127_2390723_7	1121904.ARBP01000038_gene2561	1.898e-150	479.0	COG2382@1|root,COG2382@2|Bacteria,4NF50@976|Bacteroidetes,47JIQ@768503|Cytophagia	976|Bacteroidetes	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,Glyco_hydro_10
CMS2_k127_2390723_14	1168034.FH5T_02285	1.575e-12	72.0	COG2382@1|root,COG2382@2|Bacteria,4NF50@976|Bacteroidetes,2FNWF@200643|Bacteroidia	976|Bacteroidetes	P	Enterochelin esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase
CMS2_k127_2390723_2	452637.Oter_4283	7.081e-315	982.0	COG0657@1|root,COG0657@2|Bacteria,46TU9@74201|Verrucomicrobia,3KA3K@414999|Opitutae	414999|Opitutae	I	Glycosyl hydrolase family 65, N-terminal domain	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	Glyco_hyd_65N_2
CMS2_k127_2390723_15	1226325.HMPREF1548_01355	1.639e-05	54.0	2F8I8@1|root,340X1@2|Bacteria,1VYD1@1239|Firmicutes,24SXY@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2390723_5	234267.Acid_2993	1.409e-213	685.0	COG3507@1|root,COG3507@2|Bacteria,3Y6BR@57723|Acidobacteria	57723|Acidobacteria	G	family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
CMS2_k127_2390723_3	694427.Palpr_1656	3.23e-265	827.0	COG3507@1|root,COG3507@2|Bacteria,4NEMG@976|Bacteroidetes,2FPP1@200643|Bacteroidia,22WTR@171551|Porphyromonadaceae	2|Bacteria	G	F5 8 type C domain	-	-	-	-	-	-	-	-	-	-	-	-	CBM_35,F5_F8_type_C,Glyco_hydro_43
CMS2_k127_2390723_4	234267.Acid_2989	1.273e-245	769.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	Glyco_hydro_43,RicinB_lectin_2
CMS2_k127_2390723_11	234267.Acid_2990	5.403e-93	311.0	COG3458@1|root,COG3458@2|Bacteria,3Y7GC@57723|Acidobacteria	57723|Acidobacteria	Q	cephalosporin-C deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2390723_8	452637.Oter_3237	3.964e-121	399.0	COG3507@1|root,COG3507@2|Bacteria,46TKI@74201|Verrucomicrobia,3KA3C@414999|Opitutae	2|Bacteria	G	PFAM glycoside hydrolase family 62	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Dockerin_1,Glyco_hydro_43
CMS2_k127_2390723_9	1396141.BATP01000001_gene5355	1.461e-103	348.0	COG3693@1|root,COG3693@2|Bacteria,46URW@74201|Verrucomicrobia,2IVBA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Glycosyl hydrolase family 10	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_10
CMS2_k127_2390723_13	502025.Hoch_2959	1.56e-13	75.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,4313Z@68525|delta/epsilon subdivisions,2WX2K@28221|Deltaproteobacteria,2Z2QP@29|Myxococcales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
CMS2_k127_2390723_12	1123248.KB893359_gene2189	8.781e-89	303.0	COG0657@1|root,COG2755@1|root,COG0657@2|Bacteria,COG2755@2|Bacteria,4NHBT@976|Bacteroidetes,1ISWB@117747|Sphingobacteriia	976|Bacteroidetes	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS2_k127_2390723_10	1173023.KE650772_gene5633	7.104e-97	338.0	COG1680@1|root,COG1680@2|Bacteria,1G5Z2@1117|Cyanobacteria,1JK0D@1189|Stigonemataceae	1117|Cyanobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_2390723_6	1267535.KB906767_gene5299	3.144e-185	587.0	COG1073@1|root,COG3250@1|root,COG1073@2|Bacteria,COG3250@2|Bacteria,3Y652@57723|Acidobacteria	57723|Acidobacteria	G	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2390723_0	452637.Oter_2278	0.0	1489.0	COG1073@1|root,COG3250@1|root,COG1073@2|Bacteria,COG3250@2|Bacteria,46Z55@74201|Verrucomicrobia,3K7F1@414999|Opitutae	414999|Opitutae	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
CMS2_k127_2390723_1	497964.CfE428DRAFT_3188	0.0	1026.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,DUF3857,TPR_16,TPR_8,Transglut_core
CMS2_k127_2427751_3	1191523.MROS_2633	5.946e-121	400.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	tolB3	-	-	-	-	-	-	-	-	-	-	-	PD40
CMS2_k127_2427751_7	1123508.JH636440_gene2783	4.507e-70	259.0	COG2010@1|root,COG2010@2|Bacteria,2J4WG@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_2427751_4	314230.DSM3645_29751	1.036e-118	403.0	COG2133@1|root,COG2133@2|Bacteria,2IXUJ@203682|Planctomycetes	203682|Planctomycetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS2_k127_2427751_2	1499967.BAYZ01000022_gene238	6.847e-144	465.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02058,ko:K10559	ko02010,map02010	M00220,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.9	-	-	Peripla_BP_4
CMS2_k127_2427751_1	1499967.BAYZ01000022_gene239	1.047e-161	523.0	COG1129@1|root,COG1129@2|Bacteria,2NPR8@2323|unclassified Bacteria	2|Bacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS2_k127_2427751_5	1499967.BAYZ01000022_gene240	1.547e-112	376.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS2_k127_2427751_6	1499967.BAYZ01000022_gene241	1.206e-92	329.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS2_k127_2427751_0	886379.AEWI01000003_gene581	9.474e-180	570.0	COG4030@1|root,COG4030@2|Bacteria,4NIPI@976|Bacteroidetes,2FRFX@200643|Bacteroidia	976|Bacteroidetes	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
CMS2_k127_2427751_8	314230.DSM3645_20922	3.992e-15	76.0	COG0514@1|root,COG0514@2|Bacteria,2IX4R@203682|Planctomycetes	203682|Planctomycetes	L	DEAD DEAH box helicase	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
CMS2_k127_2456077_6	309799.DICTH_0525	1.319e-61	223.0	COG0482@1|root,COG0482@2|Bacteria	2|Bacteria	J	sulfurtransferase activity	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
CMS2_k127_2456077_2	688269.Theth_0252	5.154e-129	418.0	COG0031@1|root,COG0031@2|Bacteria,2GC4Y@200918|Thermotogae	200918|Thermotogae	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_2456077_0	926692.AZYG01000040_gene1473	1.059e-185	605.0	COG0155@1|root,COG0425@1|root,COG0155@2|Bacteria,COG0425@2|Bacteria,1TS58@1239|Firmicutes,248DQ@186801|Clostridia	186801|Clostridia	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirA	-	1.7.7.1,1.8.7.1	ko:K00366,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr,TusA
CMS2_k127_2456077_13	1349785.BAUG01000003_gene258	1.929e-05	51.0	COG0243@1|root,COG0243@2|Bacteria,4NITD@976|Bacteroidetes,1I01Y@117743|Flavobacteriia	976|Bacteroidetes	C	Molybdopterin oxidoreductase	-	-	1.7.2.3,1.8.5.5	ko:K07812,ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.4,5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS2_k127_2456077_9	316067.Geob_0799	3.866e-38	147.0	COG1310@1|root,COG1310@2|Bacteria,1N3TI@1224|Proteobacteria,42TY4@68525|delta/epsilon subdivisions,2WW9Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	SMART Mov34 MPN PAD-1 family protein	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
CMS2_k127_2456077_4	589865.DaAHT2_0870	4.671e-111	365.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,42NEC@68525|delta/epsilon subdivisions,2WK08@28221|Deltaproteobacteria,2MK1G@213118|Desulfobacterales	28221|Deltaproteobacteria	H	ThiF family	moeB1	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
CMS2_k127_2456077_12	926561.KB900620_gene3115	4.231e-16	81.0	COG2104@1|root,COG2104@2|Bacteria,1VFJR@1239|Firmicutes,24SEU@186801|Clostridia	186801|Clostridia	H	thiamine biosynthesis protein ThiS	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
CMS2_k127_2456077_1	269799.Gmet_1566	5.615e-135	444.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2X70U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Cys Met metabolism	metY-3	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
CMS2_k127_2456077_8	575540.Isop_0838	4.928e-40	157.0	COG0175@1|root,COG0175@2|Bacteria,2IWXW@203682|Planctomycetes	203682|Planctomycetes	C	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
CMS2_k127_2456077_11	1123326.JFBL01000018_gene2378	1.436e-16	82.0	COG3205@1|root,COG3205@2|Bacteria,1NA8W@1224|Proteobacteria,42W08@68525|delta/epsilon subdivisions,2YQND@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Predicted membrane protein (DUF2061)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2061
CMS2_k127_2456077_10	1380390.JIAT01000009_gene1158	3.46e-25	110.0	COG1959@1|root,COG1959@2|Bacteria,2INF3@201174|Actinobacteria,4CQ7H@84995|Rubrobacteria	84995|Rubrobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS2_k127_2456077_5	335543.Sfum_1822	6.185e-105	353.0	COG0502@1|root,COG0502@2|Bacteria,1MXK0@1224|Proteobacteria,42M3U@68525|delta/epsilon subdivisions,2WJQ6@28221|Deltaproteobacteria,2MRHC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Biotin and Thiamin Synthesis associated domain	thiH	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
CMS2_k127_2456077_3	338963.Pcar_0609	1.462e-116	379.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,42MNC@68525|delta/epsilon subdivisions,2WIUI@28221|Deltaproteobacteria,43S5G@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
CMS2_k127_2471708_0	867903.ThesuDRAFT_02400	6.302e-153	487.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia,3WCCD@538999|Clostridiales incertae sedis	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
CMS2_k127_2471708_3	926569.ANT_13800	1.217e-48	178.0	COG0355@1|root,COG0355@2|Bacteria,2G70H@200795|Chloroflexi	200795|Chloroflexi	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
CMS2_k127_2471708_1	926550.CLDAP_05030	3.3e-106	355.0	COG1077@1|root,COG1077@2|Bacteria,2G5KV@200795|Chloroflexi	200795|Chloroflexi	D	TIGRFAM cell shape determining protein, MreB Mrl family	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
CMS2_k127_2471708_2	926569.ANT_13820	1.985e-76	261.0	COG2344@1|root,COG2344@2|Bacteria,2G6EJ@200795|Chloroflexi	200795|Chloroflexi	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
CMS2_k127_2471708_4	926550.CLDAP_00160	2.039e-05	56.0	COG3103@1|root,COG4991@2|Bacteria	2|Bacteria	T	sh3 domain protein	-	-	3.4.21.107,3.5.1.28	ko:K01448,ko:K04771	ko01503,ko02020,map01503,map02020	M00727,M00728	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko03036,ko03110	-	-	-	SH3_3
CMS2_k127_2527369_2	595460.RRSWK_01711	6.865e-24	105.0	COG3119@1|root,COG3119@2|Bacteria,2IXHT@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_2527369_0	313628.LNTAR_06159	6.426e-123	425.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Beta_helix,CBM_6,DUF1565,F5_F8_type_C,PEGA,Trypsin_2
CMS2_k127_2527369_1	926549.KI421517_gene2473	1.609e-69	245.0	COG3669@1|root,COG3669@2|Bacteria,4NEAP@976|Bacteroidetes,47PH6@768503|Cytophagia	976|Bacteroidetes	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Fucosidase_C
CMS2_k127_2529149_6	1068978.AMETH_1580	1.607e-10	66.0	COG4733@1|root,COG4733@2|Bacteria,2I3TX@201174|Actinobacteria,4E0NG@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
CMS2_k127_2529149_0	886293.Sinac_7047	1.722e-123	404.0	COG3828@1|root,COG3828@2|Bacteria,2IY8Q@203682|Planctomycetes	203682|Planctomycetes	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
CMS2_k127_2529149_4	1123242.JH636434_gene5601	1.526e-55	209.0	COG0707@1|root,COG0707@2|Bacteria,2J057@203682|Planctomycetes	203682|Planctomycetes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
CMS2_k127_2529149_2	443143.GM18_4316	1.764e-82	300.0	COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,1MU3S@1224|Proteobacteria,42Q3Z@68525|delta/epsilon subdivisions,2WJPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the peptidase S8 family	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Big_2,CUB,He_PIG,Peptidase_S8
CMS2_k127_2529149_3	370438.PTH_1862	1.109e-64	235.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,2619Y@186807|Peptococcaceae	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
CMS2_k127_2529149_5	760192.Halhy_0561	5.46e-27	123.0	2CM52@1|root,30ZNE@2|Bacteria,4NP1A@976|Bacteroidetes	976|Bacteroidetes	S	Psort location CytoplasmicMembrane, score 9.46	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2529149_7	1121456.ATVA01000012_gene2772	5.868e-08	58.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42RFX@68525|delta/epsilon subdivisions,2WN92@28221|Deltaproteobacteria,2M9VS@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_2529149_1	1305737.JAFX01000001_gene3410	1.367e-102	342.0	COG1082@1|root,COG1082@2|Bacteria,4NI4H@976|Bacteroidetes,47MMY@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_2533214_1	1121957.ATVL01000007_gene2414	5.028e-66	233.0	COG5434@1|root,COG5434@2|Bacteria,4NE4H@976|Bacteroidetes,47NFA@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2533214_0	1048983.EL17_09225	1.435e-217	697.0	COG3525@1|root,COG3525@2|Bacteria,4NH5U@976|Bacteroidetes,47R5K@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase, family 20, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_20b
CMS2_k127_2533214_3	794903.OPIT5_15655	1.565e-09	68.0	COG4968@1|root,COG4968@2|Bacteria,46Y4W@74201|Verrucomicrobia,3K8XU@414999|Opitutae	414999|Opitutae	NU	Protein of unknown function (DUF1559)	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_2533214_2	1121946.AUAX01000015_gene6048	9.358e-21	99.0	COG2755@1|root,COG5434@1|root,COG2755@2|Bacteria,COG5434@2|Bacteria,2II7D@201174|Actinobacteria,4D8ZD@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyl hydrolases family 28	-	-	-	-	-	-	-	-	-	-	-	-	Alpha_L_fucos,CBM_35,F5_F8_type_C,Glyco_hydro_28,Pectate_lyase_3
CMS2_k127_253674_9	56780.SYN_00446	1.851e-06	52.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,2MQT2@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	cysteine synthase A	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_253674_0	247490.KSU1_C0978	1.171e-240	767.0	COG0550@1|root,COG0550@2|Bacteria,2IY53@203682|Planctomycetes	203682|Planctomycetes	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
CMS2_k127_253674_7	1142394.PSMK_16420	1.026e-38	146.0	COG0234@1|root,COG0234@2|Bacteria,2IZTF@203682|Planctomycetes	203682|Planctomycetes	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	-	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
CMS2_k127_253674_4	1077285.AGDG01000045_gene2975	3.28e-92	338.0	COG0383@1|root,COG0383@2|Bacteria,4NI6N@976|Bacteroidetes,2FQGF@200643|Bacteroidia,4ANYA@815|Bacteroidaceae	976|Bacteroidetes	G	COG COG0383 Alpha-mannosidase	-	-	-	-	-	-	-	-	-	-	-	-	CBM-like,Glyco_hydro_38,Glyco_hydro_38C
CMS2_k127_253674_1	880073.Calab_1886	2.728e-138	451.0	COG3876@1|root,COG3876@2|Bacteria,2NNRQ@2323|unclassified Bacteria	2|Bacteria	S	PFAM Uncharacterised conserved protein UCP016719	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
CMS2_k127_253674_2	573413.Spirs_3218	1.474e-133	447.0	COG2103@1|root,COG2103@2|Bacteria	2|Bacteria	G	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	-	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	-
CMS2_k127_253674_8	743719.PaelaDRAFT_4449	1.148e-34	147.0	COG1409@1|root,COG1621@1|root,COG4632@1|root,COG5492@1|root,COG1409@2|Bacteria,COG1621@2|Bacteria,COG4632@2|Bacteria,COG5492@2|Bacteria,1UI3P@1239|Firmicutes,4HJMZ@91061|Bacilli,27713@186822|Paenibacillaceae	91061|Bacilli	GN	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Metallophos,NAGPA,Pur_ac_phosph_N,SLH
CMS2_k127_253674_3	247490.KSU1_C0348	2.01e-115	386.0	COG2377@1|root,COG2377@2|Bacteria,2IZ2P@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
CMS2_k127_253674_5	237368.SCABRO_03990	6.066e-88	302.0	COG2103@1|root,COG2103@2|Bacteria,2IWTZ@203682|Planctomycetes	203682|Planctomycetes	G	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	murQ	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS,SIS_2
CMS2_k127_253674_6	1123070.KB899248_gene116	9.615e-62	233.0	COG0591@1|root,COG0591@2|Bacteria,46SPP@74201|Verrucomicrobia,2ITZE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
CMS2_k127_2550392_18	756272.Plabr_3110	2.986e-06	50.0	COG2165@1|root,COG2165@2|Bacteria,2J22T@203682|Planctomycetes	203682|Planctomycetes	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_2550392_13	1220534.B655_2396	1.685e-51	192.0	COG2020@1|root,arCOG03580@2157|Archaea,2Y4MT@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT
CMS2_k127_2550392_16	1303518.CCALI_01224	4.842e-15	85.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02679	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_2550392_10	37727.XP_002144713.1	4.485e-74	280.0	COG0666@1|root,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3P633@4751|Fungi,3QY4D@4890|Ascomycota	4751|Fungi	M	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
CMS2_k127_2550392_15	448385.sce0976	1.227e-17	93.0	COG3428@1|root,COG3428@2|Bacteria,1Q645@1224|Proteobacteria,435EH@68525|delta/epsilon subdivisions,2WZS7@28221|Deltaproteobacteria,2Z2MQ@29|Myxococcales	28221|Deltaproteobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
CMS2_k127_2550392_6	370438.PTH_2596	1.073e-139	453.0	COG0031@1|root,COG0031@2|Bacteria,1TRM4@1239|Firmicutes,25BF7@186801|Clostridia,260E0@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM cysteine	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_2550392_1	313628.LNTAR_12216	4.511e-247	801.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_2550392_4	344747.PM8797T_06060	1.092e-145	475.0	COG0673@1|root,COG0673@2|Bacteria,2IXJ0@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_2550392_7	1210884.HG799466_gene12649	5.419e-103	343.0	COG1131@1|root,COG1131@2|Bacteria,2IY1H@203682|Planctomycetes	203682|Planctomycetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_2550392_8	1210884.HG799466_gene12650	1.108e-94	331.0	28IKQ@1|root,2Z8MC@2|Bacteria,2IXYY@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
CMS2_k127_2550392_12	1255043.TVNIR_2866	3.212e-52	202.0	28JZ9@1|root,2Z9PC@2|Bacteria,1R7GE@1224|Proteobacteria,1S7TF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2550392_17	1283284.AZUK01000001_gene2397	6.801e-13	83.0	COG1305@1|root,COG1305@2|Bacteria,1R5Q7@1224|Proteobacteria,1RPH2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	COG1305 Transglutaminase-like enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
CMS2_k127_2550392_14	272559.BF9343_4049	1.821e-36	161.0	COG1305@1|root,COG1305@2|Bacteria,4NI6P@976|Bacteroidetes,2FPYJ@200643|Bacteroidia,4APBK@815|Bacteroidaceae	976|Bacteroidetes	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,DUF3858,Transglut_core
CMS2_k127_2550392_9	880526.KE386488_gene1576	1.325e-85	314.0	COG0823@1|root,COG0823@2|Bacteria,4NIGD@976|Bacteroidetes,2G2P7@200643|Bacteroidia	976|Bacteroidetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2550392_11	1122604.JONR01000011_gene3616	7.885e-62	223.0	COG0778@1|root,COG0778@2|Bacteria,1RDJ6@1224|Proteobacteria,1SXRF@1236|Gammaproteobacteria,1XAGK@135614|Xanthomonadales	1224|Proteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS2_k127_2550392_2	1123248.KB893318_gene4216	1.731e-222	710.0	COG3534@1|root,COG3534@2|Bacteria,4NGKW@976|Bacteroidetes,1IR5F@117747|Sphingobacteriia	976|Bacteroidetes	G	Alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C,CBM_4_9
CMS2_k127_2550392_0	471854.Dfer_2269	1.46e-302	958.0	COG3250@1|root,COG3250@2|Bacteria,4NFE8@976|Bacteroidetes,47MPU@768503|Cytophagia	976|Bacteroidetes	G	glycoside hydrolase family 2 sugar binding	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
CMS2_k127_2550392_5	497964.CfE428DRAFT_5266	4.503e-143	466.0	COG1520@1|root,COG1520@2|Bacteria,46THI@74201|Verrucomicrobia	74201|Verrucomicrobia	S	SMART Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_2550392_3	452637.Oter_4336	7.491e-198	627.0	COG3534@1|root,COG3534@2|Bacteria,46UU3@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
CMS2_k127_2552968_2	1144275.COCOR_01281	1.083e-24	110.0	COG5434@1|root,COG5434@2|Bacteria,1R4PA@1224|Proteobacteria,42NNP@68525|delta/epsilon subdivisions,2WMC2@28221|Deltaproteobacteria,2YW6Z@29|Myxococcales	28221|Deltaproteobacteria	M	Pectate lyase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectate_lyase_3
CMS2_k127_2552968_1	1274524.BSONL12_04374	1.304e-27	126.0	2E2AR@1|root,32XG5@2|Bacteria,1VHHN@1239|Firmicutes	1239|Firmicutes	S	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	AP2,HNH_3
CMS2_k127_2552968_0	1121011.AUCB01000042_gene786	4.194e-147	490.0	COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,1IG0A@117743|Flavobacteriia,23IC9@178469|Arenibacter	976|Bacteroidetes	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,F5_F8_type_C
CMS2_k127_2571918_20	886293.Sinac_2100	1.552e-31	125.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS2_k127_2571918_2	204669.Acid345_2578	5.834e-215	705.0	COG0412@1|root,COG0515@1|root,COG1262@1|root,COG0412@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	57723|Acidobacteria	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_2571918_12	234267.Acid_0388	9.006e-58	216.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS2_k127_2571918_21	1177594.MIC448_830010	5.779e-31	139.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CarboxypepD_reg,HemolysinCabind
CMS2_k127_2571918_16	404589.Anae109_3838	9.585e-45	182.0	COG1409@1|root,COG1409@2|Bacteria,1NS3S@1224|Proteobacteria,43AFC@68525|delta/epsilon subdivisions,2X64J@28221|Deltaproteobacteria,2Z0UN@29|Myxococcales	28221|Deltaproteobacteria	G	Purple acid Phosphatase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
CMS2_k127_2571918_24	1177594.MIC448_830010	5.282e-18	99.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CarboxypepD_reg,HemolysinCabind
CMS2_k127_2571918_22	35754.JNYJ01000033_gene2622	1.131e-30	135.0	COG0535@1|root,COG0535@2|Bacteria,2GTTW@201174|Actinobacteria,4DIAW@85008|Micromonosporales	201174|Actinobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
CMS2_k127_2571918_9	1430440.MGMSRv2_0593	1.59e-84	302.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,2TRFJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_2571918_8	1262449.CP6013_3777	7.512e-88	299.0	COG1216@1|root,COG1216@2|Bacteria,1UYRR@1239|Firmicutes,249T1@186801|Clostridia,36HGQ@31979|Clostridiaceae	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K07011,ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,Methyltransf_23
CMS2_k127_2571918_14	406552.NJ7G_0140	2.112e-54	206.0	COG0438@1|root,COG0707@1|root,arCOG01394@2157|Archaea,arCOG01403@2157|Archaea,2XZZY@28890|Euryarchaeota,23Y2Z@183963|Halobacteria	183963|Halobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_2571918_11	1254432.SCE1572_49735	6.302e-77	263.0	COG2227@1|root,COG2227@2|Bacteria,1R7WN@1224|Proteobacteria	1224|Proteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
CMS2_k127_2571918_27	945713.IALB_0739	3.927e-09	68.0	2DDHQ@1|root,2ZI59@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2571918_26	667015.Bacsa_0065	4.715e-12	79.0	COG0560@1|root,COG0560@2|Bacteria,4NYNM@976|Bacteroidetes,2FV3B@200643|Bacteroidia,4AU8A@815|Bacteroidaceae	976|Bacteroidetes	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
CMS2_k127_2571918_4	868864.Dester_1359	1.658e-108	366.0	COG2244@1|root,COG2244@2|Bacteria,2G4JI@200783|Aquificae	200783|Aquificae	S	Polysaccharide biosynthesis protein	-	-	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt,Polysacc_synt_C
CMS2_k127_2571918_25	420247.Msm_0173	1.506e-15	91.0	arCOG02499@1|root,arCOG07611@1|root,arCOG02499@2157|Archaea,arCOG07611@2157|Archaea,2Y8GQ@28890|Euryarchaeota	28890|Euryarchaeota	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
CMS2_k127_2571918_19	497964.CfE428DRAFT_2859	1.074e-32	141.0	28SQ5@1|root,2ZF09@2|Bacteria,46WN6@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2571918_5	1396141.BATP01000024_gene782	5.9e-105	385.0	COG3523@1|root,COG3523@2|Bacteria,46VI0@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ImcF-related N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ImcF-related_N
CMS2_k127_2571918_13	497964.CfE428DRAFT_2854	1.326e-56	205.0	2DXSN@1|root,346BX@2|Bacteria,46W22@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Type VI secretion system protein DotU	-	-	-	-	-	-	-	-	-	-	-	-	DotU
CMS2_k127_2571918_3	497964.CfE428DRAFT_2853	3.703e-156	505.0	COG3522@1|root,COG3522@2|Bacteria,46UPG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE	-	-	-	-	-	-	-	-	-	-	-	-	T6SS_VasE
CMS2_k127_2571918_18	497964.CfE428DRAFT_2852	2.021e-35	147.0	2BZ98@1|root,2ZRHF@2|Bacteria,46WMB@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2571918_7	1218084.BBJK01000017_gene1827	8.429e-94	328.0	COG3520@1|root,COG3520@2|Bacteria,1MWVS@1224|Proteobacteria,2VIIT@28216|Betaproteobacteria,1K2GZ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	type VI secretion protein	-	-	-	ko:K11895	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssG
CMS2_k127_2571918_1	530564.Psta_1836	1.052e-227	721.0	COG3519@1|root,COG3519@2|Bacteria,2IYES@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM type VI secretion protein, VC_A0110 family	-	-	-	ko:K11896	-	M00334	-	-	ko00000,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssF
CMS2_k127_2571918_17	857087.Metme_0855	5.684e-38	151.0	COG3518@1|root,COG3518@2|Bacteria,1RF51@1224|Proteobacteria,1S7ZZ@1236|Gammaproteobacteria,1XFGG@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM Type VI secretion system, lysozyme-related	-	-	-	ko:K11897	-	M00334	-	-	ko00000,ko00002,ko02044	-	-	-	GPW_gp25
CMS2_k127_2571918_6	765913.ThidrDRAFT_2284	2.77e-95	320.0	COG4455@1|root,COG4455@2|Bacteria,1MWHI@1224|Proteobacteria,1RXYE@1236|Gammaproteobacteria,1X0IJ@135613|Chromatiales	135613|Chromatiales	S	ImpE protein	-	-	-	ko:K11898	-	-	-	-	ko00000,ko02044	-	-	-	ImpE
CMS2_k127_2571918_15	1265505.ATUG01000001_gene4610	3.73e-48	177.0	COG3157@1|root,COG3157@2|Bacteria,1RBTU@1224|Proteobacteria,42XEQ@68525|delta/epsilon subdivisions,2WTD9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Type VI secretion system effector, Hcp	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
CMS2_k127_2571918_0	765913.ThidrDRAFT_2282	4.553e-251	782.0	COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,1RNP7@1236|Gammaproteobacteria,1WXN1@135613|Chromatiales	135613|Chromatiales	S	Type VI secretion protein, EvpB/VC_A0108, tail sheath	-	-	-	ko:K11900	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	VipB
CMS2_k127_2571918_10	530564.Psta_1831	5.608e-84	281.0	COG3516@1|root,COG3516@2|Bacteria,2IZPA@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM type VI secretion protein, VC_A0107 family	-	-	-	ko:K11901	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VipA
CMS2_k127_2571918_23	530564.Psta_1830	2.146e-23	106.0	COG3515@1|root,COG3515@2|Bacteria,2J0E6@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM type VI secretion-associated protein, ImpA family	-	-	-	ko:K11902	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	ImpA_N
CMS2_k127_258459_14	1280681.AUJZ01000015_gene2091	1.035e-06	58.0	COG2327@1|root,COG2327@2|Bacteria,1UZDY@1239|Firmicutes,24BCV@186801|Clostridia,4BX2V@830|Butyrivibrio	186801|Clostridia	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
CMS2_k127_258459_8	877455.Metbo_0863	2.393e-90	312.0	COG1035@1|root,COG1941@1|root,arCOG02473@2157|Archaea,arCOG02652@2157|Archaea,2XZ31@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_7,FrhB_FdhB_C,FrhB_FdhB_N
CMS2_k127_258459_12	1234364.AMSF01000010_gene549	8.205e-34	145.0	COG0438@1|root,COG0438@2|Bacteria,1R564@1224|Proteobacteria,1RZBT@1236|Gammaproteobacteria,1X3JT@135614|Xanthomonadales	135614|Xanthomonadales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_258459_7	935837.JAEK01000007_gene3323	2.26e-91	319.0	COG0438@1|root,COG0438@2|Bacteria,1UYBT@1239|Firmicutes,4HCSK@91061|Bacilli,1ZE7T@1386|Bacillus	91061|Bacilli	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2,Glyco_trans_1_4,Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1
CMS2_k127_258459_3	1519464.HY22_12365	1.608e-122	403.0	COG0381@1|root,COG0381@2|Bacteria,1FDZG@1090|Chlorobi	1090|Chlorobi	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
CMS2_k127_258459_2	1499967.BAYZ01000066_gene6063	2.842e-129	426.0	COG1004@1|root,COG1004@2|Bacteria,2NQP4@2323|unclassified Bacteria	2|Bacteria	M	UDP binding domain	algD	-	1.1.1.132,1.1.1.22	ko:K00012,ko:K00066	ko00040,ko00051,ko00053,ko00520,ko01100,ko02020,map00040,map00051,map00053,map00520,map01100,map02020	M00014,M00129,M00361,M00362	R00286,R00880	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS2_k127_258459_5	1499967.BAYZ01000066_gene6062	3.026e-118	394.0	COG0438@1|root,COG0438@2|Bacteria,2NQ20@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_258459_0	1267535.KB906767_gene4370	2.63e-153	492.0	COG0399@1|root,COG0399@2|Bacteria,3Y3PT@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.98	ko:K13017	ko00520,map00520	-	R10141	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_258459_6	706587.Desti_4307	4.611e-97	333.0	COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,42NYR@68525|delta/epsilon subdivisions,2WJB1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1
CMS2_k127_258459_10	562970.Btus_0882	1.093e-51	190.0	COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,4HCBG@91061|Bacilli,279A0@186823|Alicyclobacillaceae	91061|Bacilli	M	Bacterial sugar transferase	epsL	-	-	ko:K13012,ko:K19428	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Bac_transf,CoA_binding_3
CMS2_k127_258459_1	521045.Kole_1669	2.453e-145	472.0	COG1509@1|root,COG1509@2|Bacteria,2GC9P@200918|Thermotogae	200918|Thermotogae	C	Lysine 2,3-aminomutase YodO family protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
CMS2_k127_258459_9	1121918.ARWE01000001_gene1795	6.302e-78	276.0	COG0457@1|root,COG0457@2|Bacteria,1MW49@1224|Proteobacteria,42N7T@68525|delta/epsilon subdivisions,2WK4Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_258459_13	1408445.JHXP01000032_gene1178	8.466e-16	91.0	COG0778@1|root,COG0778@2|Bacteria,1RJMP@1224|Proteobacteria,1T0ZH@1236|Gammaproteobacteria,1JEBJ@118969|Legionellales	118969|Legionellales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS2_k127_258459_11	665571.STHERM_c06320	2.251e-37	158.0	COG0693@1|root,COG0693@2|Bacteria,2JB8Z@203691|Spirochaetes	203691|Spirochaetes	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
CMS2_k127_258459_4	644282.Deba_1154	1.039e-119	398.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2WIV4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
CMS2_k127_2615178_11	1291050.JAGE01000001_gene868	9.234e-44	163.0	COG1858@1|root,COG2730@1|root,COG3391@1|root,COG1858@2|Bacteria,COG2730@2|Bacteria,COG3391@2|Bacteria,1TSS4@1239|Firmicutes,24F1E@186801|Clostridia,3WHGQ@541000|Ruminococcaceae	186801|Clostridia	GP	Ricin-type beta-trefoil	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Dockerin_1,RicinB_lectin_2
CMS2_k127_2615178_2	927658.AJUM01000007_gene2722	2.816e-136	460.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9
CMS2_k127_2615178_8	118163.Ple7327_4074	1.39e-59	212.0	28IJG@1|root,2Z8KD@2|Bacteria,1G1K7@1117|Cyanobacteria	1117|Cyanobacteria	L	XamI restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RE_XamI
CMS2_k127_2615178_9	1183438.GKIL_0151	9.751e-47	171.0	28IJG@1|root,2Z8KD@2|Bacteria,1G1K7@1117|Cyanobacteria	1117|Cyanobacteria	L	XamI restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RE_XamI
CMS2_k127_2615178_1	1173022.Cri9333_4086	3.181e-175	563.0	COG0827@1|root,COG0827@2|Bacteria,1G1QA@1117|Cyanobacteria,1H9HH@1150|Oscillatoriales	1117|Cyanobacteria	L	Pfam:Methyltransf_26	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Eco57I,N6_Mtase
CMS2_k127_2615178_6	237368.SCABRO_00250	1.858e-77	273.0	COG0501@1|root,COG0501@2|Bacteria,2J0GY@203682|Planctomycetes	203682|Planctomycetes	O	CAAX prenyl protease N-terminal, five membrane helices	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,Peptidase_M48_N
CMS2_k127_2615178_12	414996.IL38_00725	4.866e-28	115.0	2E7BZ@1|root,331V9@2|Bacteria,2GQHG@201174|Actinobacteria	201174|Actinobacteria	S	Domain of Unknown Function (DUF1540)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1540
CMS2_k127_2615178_7	945713.IALB_3118	2.255e-60	240.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PKD,Peptidase_S8
CMS2_k127_2615178_3	204669.Acid345_0637	7.428e-123	407.0	COG1680@1|root,COG1680@2|Bacteria,3Y7EG@57723|Acidobacteria,2JNJ4@204432|Acidobacteriia	204432|Acidobacteriia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_2615178_4	324602.Caur_0716	1.464e-110	385.0	COG1404@1|root,COG1404@2|Bacteria,2G87D@200795|Chloroflexi,377KU@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS2_k127_2615178_5	234267.Acid_4870	1.059e-105	351.0	COG0580@1|root,COG0580@2|Bacteria,3Y3SK@57723|Acidobacteria	57723|Acidobacteria	G	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
CMS2_k127_2615178_15	1227453.C444_11787	1.118e-06	62.0	COG4677@1|root,arCOG02495@2157|Archaea	2157|Archaea	G	COG4677 Pectin methylesterase	pecE	-	3.1.1.11	ko:K01051	ko00040,ko01100,map00040,map01100	M00081	R02362	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Beta_helix,NosD,PKD,Pectinesterase
CMS2_k127_2615178_13	192952.MM_1136	3.355e-15	90.0	COG5563@1|root,arCOG03499@1|root,arCOG03499@2157|Archaea,arCOG03501@2157|Archaea	2157|Archaea	S	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Disaggr_assoc,Disaggr_repeat,PKD
CMS2_k127_2615178_14	1123399.AQVE01000001_gene684	6.446e-10	73.0	COG3291@1|root,COG5295@1|root,COG3291@2|Bacteria,COG5295@2|Bacteria,1RGWM@1224|Proteobacteria,1SKIX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	UW	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_3
CMS2_k127_2615178_10	478741.JAFS01000002_gene788	1.429e-44	166.0	COG1371@1|root,COG1371@2|Bacteria,46YT2@74201|Verrucomicrobia,37GUG@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
CMS2_k127_2615178_0	545264.KB898755_gene2830	5.506e-200	634.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0027	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
CMS2_k127_2617417_14	1121085.AUCI01000015_gene525	7.154e-10	62.0	COG0745@1|root,COG0745@2|Bacteria,1TRNP@1239|Firmicutes,4HBUV@91061|Bacilli,1ZDSU@1386|Bacillus	91061|Bacilli	T	Transcriptional regulatory protein, C terminal	rcaC	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_2617417_2	234267.Acid_3246	8.081e-155	503.0	COG0673@1|root,COG0673@2|Bacteria,3Y76D@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_2617417_13	1122931.AUAE01000018_gene3923	3.978e-20	98.0	COG1082@1|root,COG2133@1|root,COG1082@2|Bacteria,COG2133@2|Bacteria,4NFKF@976|Bacteroidetes,2FRR2@200643|Bacteroidia,22XIX@171551|Porphyromonadaceae	976|Bacteroidetes	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_2617417_7	1068978.AMETH_5365	3.682e-76	269.0	COG4030@1|root,COG4030@2|Bacteria,2GJFD@201174|Actinobacteria,4EE98@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
CMS2_k127_2617417_6	484018.BACPLE_01017	2.475e-78	277.0	2FB4Y@1|root,343B9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2617417_5	1121430.JMLG01000005_gene806	2.559e-81	285.0	COG1533@1|root,COG1533@2|Bacteria,1TQA6@1239|Firmicutes,24A2T@186801|Clostridia,261PN@186807|Peptococcaceae	186801|Clostridia	L	Domain of unknown function (DUF1848)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1848
CMS2_k127_2617417_11	247490.KSU1_C1251	6.678e-36	149.0	COG1466@1|root,COG1466@2|Bacteria,2IZVJ@203682|Planctomycetes	203682|Planctomycetes	L	DNA polymerase III, delta' subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
CMS2_k127_2617417_0	1336243.JAEA01000005_gene1578	6.405e-221	713.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria,1JS1M@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CMS2_k127_2617417_1	1283300.ATXB01000001_gene321	2.928e-201	649.0	COG0531@1|root,COG1762@1|root,COG0531@2|Bacteria,COG1762@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria,1XE0I@135618|Methylococcales	135618|Methylococcales	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
CMS2_k127_2617417_8	1305737.JAFX01000001_gene3410	1.432e-59	217.0	COG1082@1|root,COG1082@2|Bacteria,4NI4H@976|Bacteroidetes,47MMY@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_2617417_3	861299.J421_5653	1.032e-142	471.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_2617417_9	1449063.JMLS01000011_gene313	3.797e-55	222.0	COG3669@1|root,COG3669@2|Bacteria	2|Bacteria	G	Alpha-L-fucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Alpha_L_fucos,Big_2,CBM_X2,CHB_HEX_C_1,F5_F8_type_C,FIVAR,Glyco_hyd_65N_2,Melibiase_2
CMS2_k127_2617417_4	1303518.CCALI_00184	1.94e-138	481.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	galA	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_4_9,CBM_6,DUF1565
CMS2_k127_2617417_15	1144313.PMI10_03156	6.558e-07	63.0	COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,1I0G9@117743|Flavobacteriia,2NTFA@237|Flavobacterium	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2617417_12	1033737.CAEV01000017_gene3089	1.799e-24	108.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,36W9X@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
CMS2_k127_2619992_31	1304880.JAGB01000002_gene1782	1.036e-05	48.0	COG0845@1|root,COG0845@2|Bacteria,1V2JZ@1239|Firmicutes,24A5A@186801|Clostridia	186801|Clostridia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888,ko:K15727	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1,8.A.1.2.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP
CMS2_k127_2619992_0	1121430.JMLG01000022_gene2434	1.167e-244	791.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,260X3@186807|Peptococcaceae	186801|Clostridia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS2_k127_2619992_22	945713.IALB_2856	1.158e-14	77.0	COG0347@1|root,COG0347@2|Bacteria	2|Bacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	DUF3240,P-II
CMS2_k127_2619992_12	485913.Krac_11264	1.228e-53	197.0	COG0363@1|root,COG0363@2|Bacteria,2G6S0@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glucosamine galactosamine-6-phosphate isomerase	-	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
CMS2_k127_2619992_29	1121352.JHZP01000004_gene1501	1.014e-09	66.0	COG1652@1|root,COG1652@2|Bacteria,1RD8K@1224|Proteobacteria,2VR7C@28216|Betaproteobacteria,2KR8C@206351|Neisseriales	206351|Neisseriales	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,LysM
CMS2_k127_2619992_3	1142394.PSMK_23630	4.034e-163	557.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,2IYCQ@203682|Planctomycetes	203682|Planctomycetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4	-	-	SecD_SecF,Sec_GG
CMS2_k127_2619992_25	382464.ABSI01000006_gene900	3.263e-12	75.0	COG1862@1|root,COG1862@2|Bacteria,46T88@74201|Verrucomicrobia,2IUY8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	U	Preprotein translocase subunit	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
CMS2_k127_2619992_5	521674.Plim_1347	6.413e-121	404.0	COG0343@1|root,COG0343@2|Bacteria,2IWXI@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
CMS2_k127_2619992_16	314278.NB231_17555	2.567e-35	151.0	COG2385@1|root,COG2385@2|Bacteria,1RGJS@1224|Proteobacteria	1224|Proteobacteria	D	Stage II sporulation D domain protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID,TPR_6,TPR_8
CMS2_k127_2619992_9	886293.Sinac_5630	3.88e-88	308.0	COG0202@1|root,COG0457@1|root,COG0202@2|Bacteria,COG0457@2|Bacteria,2IXMK@203682|Planctomycetes	203682|Planctomycetes	K	rna polymerase alpha	-	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,TPR_1,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
CMS2_k127_2619992_15	96561.Dole_1791	1.911e-42	182.0	COG1044@1|root,COG1361@1|root,COG1653@1|root,COG1044@2|Bacteria,COG1361@2|Bacteria,COG1653@2|Bacteria,1N4S6@1224|Proteobacteria,43BRE@68525|delta/epsilon subdivisions,2X729@28221|Deltaproteobacteria,2MNRP@213118|Desulfobacterales	1224|Proteobacteria	G	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2619992_20	856793.MICA_1642	3.072e-20	108.0	COG1520@1|root,COG3534@1|root,COG1520@2|Bacteria,COG3534@2|Bacteria	2|Bacteria	G	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43,Laminin_G_3,PQQ_2
CMS2_k127_2619992_17	1232410.KI421412_gene29	7.594e-30	121.0	COG0431@1|root,COG0431@2|Bacteria,1RAFI@1224|Proteobacteria,42U4J@68525|delta/epsilon subdivisions,2WQ0R@28221|Deltaproteobacteria,43V9N@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
CMS2_k127_2619992_21	941449.dsx2_0178	8.811e-16	79.0	COG0431@1|root,COG0431@2|Bacteria,1RAFI@1224|Proteobacteria,42U4J@68525|delta/epsilon subdivisions,2WQ0R@28221|Deltaproteobacteria,2MGI5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM NADPH-dependent FMN reductase	-	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
CMS2_k127_2619992_30	351160.RRC291	1.968e-07	55.0	COG0431@1|root,arCOG04624@2157|Archaea,2XWKS@28890|Euryarchaeota	28890|Euryarchaeota	S	NAD(P)H-dependent FMN reductase	ssuE1	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
CMS2_k127_2619992_7	404589.Anae109_4065	2.021e-104	346.0	COG0702@1|root,COG0702@2|Bacteria,1N3GN@1224|Proteobacteria,43F3M@68525|delta/epsilon subdivisions,2X39K@28221|Deltaproteobacteria,2YUZE@29|Myxococcales	28221|Deltaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
CMS2_k127_2619992_10	1499967.BAYZ01000024_gene278	4.254e-68	244.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS2_k127_2619992_32	404380.Gbem_2505	0.0001954	50.0	COG3322@1|root,COG3322@2|Bacteria,1REX0@1224|Proteobacteria	1224|Proteobacteria	T	CHASE4 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2619992_14	96561.Dole_1791	2.705e-44	183.0	COG1044@1|root,COG1361@1|root,COG1653@1|root,COG1044@2|Bacteria,COG1361@2|Bacteria,COG1653@2|Bacteria,1N4S6@1224|Proteobacteria,43BRE@68525|delta/epsilon subdivisions,2X729@28221|Deltaproteobacteria,2MNRP@213118|Desulfobacterales	1224|Proteobacteria	G	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2619992_8	1121430.JMLG01000002_gene1059	2.276e-101	346.0	COG1032@1|root,COG1032@2|Bacteria,1TRZA@1239|Firmicutes,24B00@186801|Clostridia,263EX@186807|Peptococcaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_2619992_1	1121904.ARBP01000008_gene3234	1.511e-219	702.0	COG5492@1|root,COG5492@2|Bacteria,4NEAB@976|Bacteroidetes,47TBW@768503|Cytophagia	976|Bacteroidetes	N	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060
CMS2_k127_2619992_11	497964.CfE428DRAFT_4864	6.363e-63	224.0	COG1595@1|root,COG1595@2|Bacteria,46VE8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2619992_2	886293.Sinac_6489	5.561e-193	640.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
CMS2_k127_2619992_19	335543.Sfum_3155	1.897e-24	119.0	COG2234@1|root,COG2234@2|Bacteria,1MXJC@1224|Proteobacteria,42RKA@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS2_k127_2619992_24	321327.CYA_0280	3.317e-13	83.0	COG5306@1|root,COG5306@2|Bacteria	2|Bacteria	-	-	exbB2	-	-	ko:K03561,ko:K12287	-	-	-	-	ko00000,ko02000,ko02044	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
CMS2_k127_2619992_4	1396418.BATQ01000010_gene3751	3.848e-128	449.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,46UAE@74201|Verrucomicrobia,2IV44@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_12,WD40
CMS2_k127_2619992_18	313628.LNTAR_24214	4.194e-25	115.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_2619992_6	509191.AEDB02000022_gene2935	2.226e-114	400.0	COG2006@1|root,COG2006@2|Bacteria,1VRZ8@1239|Firmicutes,24Z9V@186801|Clostridia,3WN5G@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Dockerin_1
CMS2_k127_2619992_26	690850.Desaf_0775	2.372e-11	78.0	COG5434@1|root,COG5434@2|Bacteria,1R1I5@1224|Proteobacteria,4320W@68525|delta/epsilon subdivisions,2WWIY@28221|Deltaproteobacteria	2|Bacteria	M	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2619992_13	234267.Acid_5504	8.856e-48	192.0	2C750@1|root,33NYP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2619992_23	935567.JAES01000010_gene1812	3.305e-13	77.0	COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1S8HN@1236|Gammaproteobacteria,1X62E@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_2619992_27	886293.Sinac_0045	7.262e-11	74.0	2DNXT@1|root,32ZQ4@2|Bacteria,2J16C@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2619992_28	663278.Ethha_2606	8.06e-11	70.0	COG1595@1|root,COG1595@2|Bacteria,1V4B8@1239|Firmicutes,24KEK@186801|Clostridia,3WM37@541000|Ruminococcaceae	186801|Clostridia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_263136_6	1123320.KB889698_gene9323	2.421e-12	80.0	COG2133@1|root,COG3055@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3055@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Calx-beta,GSDH,Laminin_G_3,Malectin,PKD
CMS2_k127_263136_4	1408813.AYMG01000034_gene4493	3.873e-34	150.0	COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1IPCG@117747|Sphingobacteriia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
CMS2_k127_263136_5	1392490.JHZX01000001_gene2739	3.424e-25	123.0	COG4099@1|root,COG4099@2|Bacteria,4NXXH@976|Bacteroidetes,1I8XK@117743|Flavobacteriia	976|Bacteroidetes	S	phospholipase Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_263136_2	278957.ABEA03000117_gene1091	1.366e-65	252.0	COG2755@1|root,COG4099@1|root,COG2755@2|Bacteria,COG4099@2|Bacteria,46XFG@74201|Verrucomicrobia,3K9WS@414999|Opitutae	414999|Opitutae	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_263136_3	1499967.BAYZ01000018_gene6346	1.226e-54	198.0	COG0698@1|root,COG0698@2|Bacteria,2NPF4@2323|unclassified Bacteria	2|Bacteria	G	ribose 5-phosphate isomerase B	rpiB	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005576,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2465c	LacAB_rpiB
CMS2_k127_263136_1	1033743.CAES01000002_gene1777	2.106e-113	387.0	COG1283@1|root,COG1283@2|Bacteria,1TP4K@1239|Firmicutes,4HAZ0@91061|Bacilli,26VCR@186822|Paenibacillaceae	91061|Bacilli	P	Na+/Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
CMS2_k127_263136_0	1089547.KB913013_gene1258	9.149e-118	389.0	COG1053@1|root,COG1053@2|Bacteria,4NG03@976|Bacteroidetes,47JE3@768503|Cytophagia	976|Bacteroidetes	C	Glucose inhibited division protein A	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
CMS2_k127_2650644_8	382464.ABSI01000011_gene2465	4.847e-41	164.0	COG2273@1|root,COG3291@1|root,COG5297@1|root,COG2273@2|Bacteria,COG3291@2|Bacteria,COG5297@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase family 6	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CBM_4_9,CBM_6,Glyco_hydro_16,Laminin_G_3,PKD
CMS2_k127_2650644_7	1293054.HSACCH_00893	1.211e-45	178.0	COG4952@1|root,COG4952@2|Bacteria,1UD8H@1239|Firmicutes,24HDU@186801|Clostridia,3WBZR@53433|Halanaerobiales	186801|Clostridia	M	Xylose isomerase-like TIM barrel	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
CMS2_k127_2650644_0	1122176.KB903540_gene9	1.456e-146	471.0	COG1082@1|root,COG1082@2|Bacteria,4NGBE@976|Bacteroidetes,1IW8K@117747|Sphingobacteriia	976|Bacteroidetes	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
CMS2_k127_2650644_5	526227.Mesil_0837	3.962e-73	262.0	COG3828@1|root,COG3828@2|Bacteria,1WN34@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,ThuA,VCBS
CMS2_k127_2650644_6	706587.Desti_1456	1.28e-59	209.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	prx-4	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
CMS2_k127_2650644_3	926550.CLDAP_32280	9.171e-96	323.0	COG2390@1|root,COG2390@2|Bacteria,2G8CS@200795|Chloroflexi	200795|Chloroflexi	K	Putative sugar-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r4,Sugar-bind
CMS2_k127_2650644_1	553973.CLOHYLEM_06017	2.728e-113	376.0	COG1879@1|root,COG1879@2|Bacteria,1VZQZ@1239|Firmicutes,253Z7@186801|Clostridia	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
CMS2_k127_2650644_4	553973.CLOHYLEM_06016	1.457e-91	315.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
CMS2_k127_2650644_2	553973.CLOHYLEM_06015	2.127e-111	368.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,21XVN@1506553|Lachnoclostridium	186801|Clostridia	P	Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
CMS2_k127_2653039_9	1396141.BATP01000060_gene4765	5.89e-20	104.0	COG0028@1|root,COG2730@1|root,COG2755@1|root,COG2931@1|root,COG3506@1|root,COG3637@1|root,COG4733@1|root,COG5184@1|root,COG0028@2|Bacteria,COG2730@2|Bacteria,COG2755@2|Bacteria,COG2931@2|Bacteria,COG3506@2|Bacteria,COG3637@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,46Z9Q@74201|Verrucomicrobia,2IVEQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	DEGMUZ	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
CMS2_k127_2653039_4	439235.Dalk_3395	1.458e-124	411.0	COG1533@1|root,COG1533@2|Bacteria,1NWJ9@1224|Proteobacteria,42P30@68525|delta/epsilon subdivisions,2WIPV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	radical SAM domain protein	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	-
CMS2_k127_2653039_0	926550.CLDAP_32450	5.122e-225	707.0	COG1070@1|root,COG1070@2|Bacteria,2G5QX@200795|Chloroflexi	2|Bacteria	G	PFAM carbohydrate kinase	-	-	2.7.1.12,2.7.1.17,2.7.1.215,2.7.1.5	ko:K00848,ko:K00851,ko:K00854,ko:K00862	ko00030,ko00040,ko00051,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00040,map00051,map01100,map01110,map01120,map01130,map01200	M00014	R01639,R01737,R01902,R03014,R11536	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
CMS2_k127_2653039_2	700598.Niako_0063	3.309e-199	631.0	COG2407@1|root,COG2407@2|Bacteria,4NFGS@976|Bacteroidetes,1IQRA@117747|Sphingobacteriia	976|Bacteroidetes	G	PFAM L-fucose isomerase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Fucose_iso_C
CMS2_k127_2653039_3	553973.CLOHYLEM_06006	1.765e-133	439.0	COG4091@1|root,COG4091@2|Bacteria,1TR51@1239|Firmicutes,24AUF@186801|Clostridia,223VP@1506553|Lachnoclostridium	186801|Clostridia	E	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DapB_N,F420_oxidored,NAD_binding_3,SAF
CMS2_k127_2653039_5	926550.CLDAP_32440	8.161e-122	399.0	COG1063@1|root,COG1063@2|Bacteria,2G6PM@200795|Chloroflexi	200795|Chloroflexi	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS2_k127_2653039_8	1304865.JAGF01000001_gene888	3.432e-39	153.0	COG0794@1|root,COG0794@2|Bacteria,2IE8A@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Sugar isomerase (SIS)	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS
CMS2_k127_2653039_1	1121904.ARBP01000013_gene373	2.595e-221	698.0	COG2730@1|root,COG2730@2|Bacteria,4P1NI@976|Bacteroidetes,47TT8@768503|Cytophagia	976|Bacteroidetes	G	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038,DUF5060
CMS2_k127_2653039_6	290400.Jann_3057	5.513e-98	338.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2TV15@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440,ko:K17203	ko02010,map02010	M00212,M00590	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.11,3.A.1.2.13,3.A.1.2.16,3.A.1.2.19	-	-	BPD_transp_2
CMS2_k127_2653039_7	1089551.KE386572_gene1627	6.589e-62	220.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,4BR8I@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS2_k127_2668246_1	1304880.JAGB01000002_gene1967	6.795e-85	284.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,24969@186801|Clostridia	186801|Clostridia	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_2668246_4	1123388.AQWU01000033_gene1751	6.148e-35	148.0	COG0801@1|root,COG0801@2|Bacteria,1WJU9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	TIGRFAM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
CMS2_k127_2668246_0	370438.PTH_0221	3.66e-92	311.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,26011@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
CMS2_k127_2668246_5	349161.Dred_0162	4.247e-34	134.0	COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia,26265@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
CMS2_k127_2668246_3	575540.Isop_0883	1.268e-42	169.0	COG0682@1|root,COG0682@2|Bacteria,2IZQ2@203682|Planctomycetes	203682|Planctomycetes	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT,PDZ
CMS2_k127_2668246_7	56780.SYN_02429	1.316e-05	53.0	COG3462@1|root,COG3462@2|Bacteria,1Q55M@1224|Proteobacteria,42WZ8@68525|delta/epsilon subdivisions,2WSP8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
CMS2_k127_2668246_2	1499968.TCA2_2001	5.889e-57	211.0	COG1011@1|root,COG1011@2|Bacteria,1TS3W@1239|Firmicutes,4HADE@91061|Bacilli,26QMB@186822|Paenibacillaceae	91061|Bacilli	S	haloacid dehalogenase	ysaA	-	3.1.3.5,3.8.1.2	ko:K01560,ko:K07025,ko:K08723	ko00230,ko00240,ko00361,ko00625,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00760,map01100,map01110,map01120	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R05287	RC00017,RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS2_k127_2668246_6	644282.Deba_1697	1.447e-24	107.0	COG0500@1|root,COG2226@2|Bacteria,1N3WC@1224|Proteobacteria,42URQ@68525|delta/epsilon subdivisions,2WQGW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
CMS2_k127_2693544_7	886293.Sinac_4705	2.832e-12	79.0	COG2834@1|root,COG2834@2|Bacteria,2J4MG@203682|Planctomycetes	203682|Planctomycetes	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2693544_5	335543.Sfum_3308	4.199e-25	105.0	2E32K@1|root,32Y2U@2|Bacteria,1N8SE@1224|Proteobacteria,42WC1@68525|delta/epsilon subdivisions,2WS7P@28221|Deltaproteobacteria,2MQPE@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2693544_1	1408473.JHXO01000003_gene2545	5.438e-59	214.0	COG0491@1|root,COG0491@2|Bacteria,4NPPW@976|Bacteroidetes,2FS1P@200643|Bacteroidia	976|Bacteroidetes	S	Metallo-beta-lactamase superfamily	ccrA	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
CMS2_k127_2693544_2	215803.DB30_3950	2.472e-56	206.0	COG0546@1|root,COG0546@2|Bacteria,1REXF@1224|Proteobacteria,43B2S@68525|delta/epsilon subdivisions,2X09C@28221|Deltaproteobacteria,2Z0P3@29|Myxococcales	28221|Deltaproteobacteria	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS2_k127_2693544_0	1449063.JMLS01000002_gene1074	5.409e-73	271.0	COG5434@1|root,COG5434@2|Bacteria,1TQQW@1239|Firmicutes,4HDV0@91061|Bacilli	91061|Bacilli	M	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28
CMS2_k127_2693544_3	760568.Desku_3099	7.736e-49	177.0	COG5550@1|root,COG5550@2|Bacteria,1W58U@1239|Firmicutes,255IM@186801|Clostridia	186801|Clostridia	O	TIGRFAM clan AA aspartic protease, AF_0612 family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2693544_6	234267.Acid_6615	2.429e-15	87.0	28KX8@1|root,2ZAD8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2693544_4	700598.Niako_1749	1.506e-42	163.0	COG3828@1|root,COG3828@2|Bacteria,4NRZF@976|Bacteroidetes,1IVGZ@117747|Sphingobacteriia	976|Bacteroidetes	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
CMS2_k127_2694973_29	1123248.KB893381_gene955	1.392e-49	189.0	COG3408@1|root,COG3408@2|Bacteria,4P4HZ@976|Bacteroidetes	976|Bacteroidetes	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2694973_37	234267.Acid_3493	3.082e-16	83.0	COG0457@1|root,COG0457@2|Bacteria,3Y75T@57723|Acidobacteria	57723|Acidobacteria	S	Iodothyronine deiodinase	-	-	-	-	-	-	-	-	-	-	-	-	T4_deiodinase,TPR_16
CMS2_k127_2694973_8	1403819.BATR01000053_gene1609	7.091e-147	484.0	COG3119@1|root,COG3119@2|Bacteria,46TNU@74201|Verrucomicrobia,2IUAA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_2694973_25	314230.DSM3645_20802	6.925e-65	229.0	COG1082@1|root,COG1082@2|Bacteria,2J52H@203682|Planctomycetes	203682|Planctomycetes	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_2694973_13	1499967.BAYZ01000027_gene1815	1.403e-110	370.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
CMS2_k127_2694973_2	1150600.ADIARSV_0055	9.732e-248	786.0	28MHM@1|root,2ZAUH@2|Bacteria,4NKMG@976|Bacteroidetes,1IWWX@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2694973_31	316067.Geob_0102	1.91e-38	151.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,42SCH@68525|delta/epsilon subdivisions,2WPMA@28221|Deltaproteobacteria,43SR2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS2_k127_2694973_24	1499967.BAYZ01000105_gene3531	5.469e-66	238.0	COG1975@1|root,COG1975@2|Bacteria,2NPTS@2323|unclassified Bacteria	2|Bacteria	O	XdhC and CoxI family	pucA	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
CMS2_k127_2694973_22	452637.Oter_3128	1.916e-69	238.0	COG2080@1|root,COG2080@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CMS2_k127_2694973_1	1047013.AQSP01000139_gene2342	3.528e-305	953.0	COG1529@1|root,COG1529@2|Bacteria,2NPHP@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS2_k127_2694973_18	1408473.JHXO01000001_gene2057	4.434e-88	302.0	COG1409@1|root,COG1409@2|Bacteria,4NPFR@976|Bacteroidetes,2G2Q5@200643|Bacteroidia	976|Bacteroidetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_2694973_3	1267533.KB906738_gene2186	2.097e-239	760.0	COG1529@1|root,COG1529@2|Bacteria,3Y3J7@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C2
CMS2_k127_2694973_28	1340493.JNIF01000003_gene2233	1.081e-51	187.0	COG2080@1|root,COG2080@2|Bacteria,3Y5EJ@57723|Acidobacteria	57723|Acidobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CMS2_k127_2694973_16	1499967.BAYZ01000095_gene4075	1.64e-98	328.0	COG2220@1|root,COG2220@2|Bacteria,2NQD1@2323|unclassified Bacteria	2|Bacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CMS2_k127_2694973_0	926549.KI421517_gene3299	0.0	1020.0	COG1874@1|root,COG1874@2|Bacteria,4NQBQ@976|Bacteroidetes,47QIS@768503|Cytophagia	976|Bacteroidetes	G	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
CMS2_k127_2694973_20	398720.MED217_13359	1.565e-73	266.0	COG1082@1|root,COG2152@1|root,COG1082@2|Bacteria,COG2152@2|Bacteria,4NGDZ@976|Bacteroidetes,1HYH2@117743|Flavobacteriia,2XJU1@283735|Leeuwenhoekiella	976|Bacteroidetes	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_2694973_14	1123508.JH636450_gene7084	3.219e-108	367.0	COG3828@1|root,COG3828@2|Bacteria,2IX0E@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,ThuA
CMS2_k127_2694973_26	1082931.KKY_2671	4.44e-55	209.0	COG1397@1|root,COG1397@2|Bacteria	2|Bacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
CMS2_k127_2694973_34	1382306.JNIM01000001_gene1943	1.062e-28	126.0	COG2047@1|root,COG2047@2|Bacteria,2G9KI@200795|Chloroflexi	200795|Chloroflexi	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
CMS2_k127_2694973_27	1396141.BATP01000003_gene4865	3.622e-54	219.0	COG1749@1|root,COG2755@1|root,COG3291@1|root,COG1749@2|Bacteria,COG2755@2|Bacteria,COG3291@2|Bacteria,46VBR@74201|Verrucomicrobia,2IUWJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	PA14	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF1800,DUF5011,PA14
CMS2_k127_2694973_10	595460.RRSWK_03954	4.796e-140	455.0	COG2730@1|root,COG2730@2|Bacteria,2IWW8@203682|Planctomycetes	203682|Planctomycetes	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
CMS2_k127_2694973_11	497964.CfE428DRAFT_1056	2.135e-122	408.0	COG3119@1|root,COG3119@2|Bacteria,46VGR@74201|Verrucomicrobia	74201|Verrucomicrobia	NP	Ig domain protein group 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Sulfatase
CMS2_k127_2694973_5	583355.Caka_1736	3.097e-218	722.0	COG2312@1|root,COG2312@2|Bacteria,46TMX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH,LTD
CMS2_k127_2694973_4	1235803.C825_03594	3.102e-236	771.0	COG1262@1|root,COG1262@2|Bacteria,4NKT6@976|Bacteroidetes,2FR3S@200643|Bacteroidia	976|Bacteroidetes	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS2_k127_2694973_41	589865.DaAHT2_0192	3.064e-05	52.0	2DR7G@1|root,33AJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2694973_6	1121396.KB893094_gene4441	3.665e-217	700.0	COG0531@1|root,COG0531@2|Bacteria,1R4IZ@1224|Proteobacteria,42MTQ@68525|delta/epsilon subdivisions,2WK39@28221|Deltaproteobacteria,2MIIG@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,SLC12
CMS2_k127_2694973_21	1394178.AWOO02000002_gene1762	1.683e-70	252.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria	201174|Actinobacteria	Q	2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
CMS2_k127_2694973_30	575540.Isop_0883	9.632e-42	167.0	COG0682@1|root,COG0682@2|Bacteria,2IZQ2@203682|Planctomycetes	203682|Planctomycetes	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT,PDZ
CMS2_k127_2694973_9	1168034.FH5T_03280	3.672e-146	490.0	COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	dppX	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
CMS2_k127_2694973_32	1142394.PSMK_23290	1.223e-33	140.0	COG0705@1|root,COG0705@2|Bacteria,2J0D1@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS2_k127_2694973_40	314256.OG2516_17845	1.413e-07	63.0	2DBK2@1|root,2Z9Q1@2|Bacteria,1NTTR@1224|Proteobacteria,2UPZJ@28211|Alphaproteobacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2694973_33	497964.CfE428DRAFT_5014	2.294e-32	147.0	COG2304@1|root,COG3055@1|root,COG3119@1|root,COG3291@1|root,COG2304@2|Bacteria,COG3055@2|Bacteria,COG3119@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	rapB1	-	3.2.1.4	ko:K01179,ko:K07004,ko:K12548	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Laminin_G_3
CMS2_k127_2694973_39	1122927.KB895431_gene78	7.512e-10	73.0	COG0383@1|root,COG2120@1|root,COG3210@1|root,COG4099@1|root,COG4733@1|root,COG5184@1|root,COG5276@1|root,COG0383@2|Bacteria,COG2120@2|Bacteria,COG3210@2|Bacteria,COG4099@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	3.2.1.24,3.4.24.40	ko:K01191,ko:K01406,ko:K20276	ko00511,ko01503,ko02024,map00511,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04131	-	GH38	-	Big_2,Cohesin,F5_F8_type_C,PIG-L,RCC1_2
CMS2_k127_2694973_36	326427.Cagg_2227	8.38e-20	96.0	COG1595@1|root,COG1595@2|Bacteria,2G6MG@200795|Chloroflexi,375K5@32061|Chloroflexia	32061|Chloroflexia	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_2694973_12	138119.DSY2130	1.064e-111	379.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260RG@186807|Peptococcaceae	186801|Clostridia	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
CMS2_k127_2694973_7	595460.RRSWK_01782	1.715e-152	493.0	COG0304@1|root,COG0304@2|Bacteria,2IWRA@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS2_k127_2694973_35	886293.Sinac_1364	5.606e-26	109.0	COG0236@1|root,COG0236@2|Bacteria,2J0V5@203682|Planctomycetes	203682|Planctomycetes	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CMS2_k127_2694973_23	556261.HMPREF0240_00427	1.167e-68	241.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,36EGR@31979|Clostridiaceae	186801|Clostridia	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS2_k127_2694973_19	344747.PM8797T_17794	4.815e-82	283.0	COG0331@1|root,COG0331@2|Bacteria,2IXX2@203682|Planctomycetes	203682|Planctomycetes	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
CMS2_k127_2694973_15	1408422.JHYF01000001_gene2940	5.321e-102	342.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,36DR2@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS2_k127_2694973_17	1142394.PSMK_17290	7.853e-94	321.0	COG0416@1|root,COG0416@2|Bacteria,2IWUY@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
CMS2_k127_2694973_38	1142394.PSMK_17300	2.195e-10	64.0	COG0333@1|root,COG0333@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
CMS2_k127_2767996_3	714943.Mucpa_2422	7.358e-29	128.0	COG3507@1|root,COG3507@2|Bacteria,4NI92@976|Bacteroidetes,1ISQE@117747|Sphingobacteriia	976|Bacteroidetes	G	Coagulation factor 5 8 type, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Glyco_hydro_43,Laminin_G_3
CMS2_k127_2767996_4	649349.Lbys_0109	2.461e-21	110.0	COG3507@1|root,COG3507@2|Bacteria,4NEIZ@976|Bacteroidetes,47NFQ@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
CMS2_k127_2767996_2	714943.Mucpa_2422	1.163e-29	138.0	COG3507@1|root,COG3507@2|Bacteria,4NI92@976|Bacteroidetes,1ISQE@117747|Sphingobacteriia	976|Bacteroidetes	G	Coagulation factor 5 8 type, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Glyco_hydro_43,Laminin_G_3
CMS2_k127_2767996_6	660470.Theba_1661	5.506e-08	67.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2767996_5	697281.Mahau_0770	4.18e-08	67.0	28HEJ@1|root,2Z7QZ@2|Bacteria,1VVD9@1239|Firmicutes,250PS@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4185)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185
CMS2_k127_2767996_0	1396141.BATP01000051_gene3312	1.994e-46	193.0	COG3209@1|root,COG3266@1|root,COG3209@2|Bacteria,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Gram_pos_anchor,MucBP,Phospholip_A2_3,YSIRK_signal
CMS2_k127_2767996_1	1122925.KB895385_gene3064	1.244e-43	173.0	COG3507@1|root,COG3533@1|root,COG3507@2|Bacteria,COG3533@2|Bacteria,1U157@1239|Firmicutes,4HT9T@91061|Bacilli,26UV2@186822|Paenibacillaceae	91061|Bacilli	G	Concanavalin A-like lectin/glucanases superfamily	M1-853	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS2_k127_2769481_4	517418.Ctha_1865	1.306e-47	186.0	COG5184@1|root,COG5492@1|root,COG5184@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,CHU_C,Calx-beta,ChW,Flg_new,Glug,Phage_TTP_12,RCC1
CMS2_k127_2769481_2	583355.Caka_1113	4.271e-48	182.0	2ERTX@1|root,33JD4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2769481_6	1123517.JOMR01000001_gene1703	8.853e-23	108.0	COG2866@1|root,COG2866@2|Bacteria,1N9AY@1224|Proteobacteria,1RRGU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Murein peptide amidase A	mpaA	GO:0000270,GO:0003674,GO:0003824,GO:0004040,GO:0004180,GO:0004181,GO:0005488,GO:0006022,GO:0006026,GO:0006027,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009050,GO:0009056,GO:0009057,GO:0009253,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0030203,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0046872,GO:0046914,GO:0061473,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	-	ko:K14054	-	-	-	-	ko00000	-	-	iEC55989_1330.EC55989_1490,iECO103_1326.ECO103_1491	Peptidase_M14
CMS2_k127_2769481_0	530564.Psta_4250	9.383e-273	854.0	COG0556@1|root,COG0556@2|Bacteria,2IWS1@203682|Planctomycetes	203682|Planctomycetes	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
CMS2_k127_2769481_1	1303518.CCALI_00718	1.603e-71	253.0	COG0157@1|root,COG0157@2|Bacteria	2|Bacteria	H	quinolinate catabolic process	nadC	GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1988,iHN637.CLJU_RS12010,iLJ478.TM1645	QRPTase_C,QRPTase_N
CMS2_k127_2769481_5	886293.Sinac_6786	3.468e-41	163.0	COG0340@1|root,COG0340@2|Bacteria,2J01C@203682|Planctomycetes	203682|Planctomycetes	H	PFAM Biotin lipoate A B protein ligase	-	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
CMS2_k127_2769481_3	794903.OPIT5_10385	8.722e-48	180.0	COG5434@1|root,COG5434@2|Bacteria,46YBC@74201|Verrucomicrobia,3K995@414999|Opitutae	414999|Opitutae	M	Pectate lyase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectate_lyase_3
CMS2_k127_2777516_7	1121895.Q765_18740	3.728e-06	60.0	COG0457@1|root,COG0457@2|Bacteria,4NG1I@976|Bacteroidetes,1HXHP@117743|Flavobacteriia,2NTTP@237|Flavobacterium	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
CMS2_k127_2777516_4	1384054.N790_01640	3.825e-16	88.0	COG1595@1|root,COG1595@2|Bacteria,1RCMS@1224|Proteobacteria,1S55Z@1236|Gammaproteobacteria,1X59U@135614|Xanthomonadales	135614|Xanthomonadales	K	RNA polymerase sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_2777516_6	1254432.SCE1572_27480	7.158e-07	61.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ECF,Sigma70_r2,Sigma70_r4_2
CMS2_k127_2777516_2	593750.Metfor_2855	4.646e-55	200.0	COG2518@1|root,arCOG00976@2157|Archaea,2XTRM@28890|Euryarchaeota,2N9U4@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CMS2_k127_2777516_1	1238184.CM001792_gene1062	4.648e-63	224.0	COG0730@1|root,COG0730@2|Bacteria,1UCVY@1239|Firmicutes,4HG2T@91061|Bacilli,23K3Z@182709|Oceanobacillus	91061|Bacilli	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS2_k127_2777516_3	1408473.JHXO01000009_gene3379	1.423e-17	91.0	2BXUX@1|root,32R23@2|Bacteria,4NR4Y@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2777516_0	247490.KSU1_B0390	7.66e-168	544.0	COG0029@1|root,COG0029@2|Bacteria,2IY30@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CMS2_k127_2777516_5	272624.lpg1742	1.022e-07	59.0	2E9J1@1|root,333RY@2|Bacteria,1NIX0@1224|Proteobacteria,1SGM0@1236|Gammaproteobacteria,1JFBK@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_277891_0	1047013.AQSP01000084_gene768	4.26e-52	194.0	COG1801@1|root,COG1801@2|Bacteria,2NPDU@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
CMS2_k127_277891_1	351627.Csac_2042	6.543e-32	134.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,42G7Y@68295|Thermoanaerobacterales	186801|Clostridia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
CMS2_k127_277891_2	1387312.BAUS01000002_gene652	2.702e-19	96.0	2DNTV@1|root,32Z41@2|Bacteria,1NAXI@1224|Proteobacteria	1224|Proteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
CMS2_k127_2778943_4	693979.Bache_0230	5.904e-11	68.0	28KYZ@1|root,2ZAEB@2|Bacteria,4NHBZ@976|Bacteroidetes,2FP4X@200643|Bacteroidia,4AMVW@815|Bacteroidaceae	976|Bacteroidetes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2778943_1	411477.PARMER_04098	1.398e-98	345.0	COG0823@1|root,COG0823@2|Bacteria,4NGH4@976|Bacteroidetes,2FN8G@200643|Bacteroidia	976|Bacteroidetes	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
CMS2_k127_2778943_0	693986.MOC_1461	3.065e-107	359.0	COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria,2V7PY@28211|Alphaproteobacteria,1JYNR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_2778943_2	1487923.DP73_21660	4.545e-72	261.0	COG5598@1|root,COG5598@2|Bacteria,1UY21@1239|Firmicutes,248BQ@186801|Clostridia,260DN@186807|Peptococcaceae	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
CMS2_k127_2778943_3	861299.J421_5955	1.599e-34	133.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	MA20_02630	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_2798753_0	641524.ADICYQ_0050	1.326e-148	486.0	COG3119@1|root,COG3119@2|Bacteria,4NHSS@976|Bacteroidetes,47XAI@768503|Cytophagia	976|Bacteroidetes	P	Protein of unknown function (DUF229)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_2798753_5	861208.AGROH133_10142	1.902e-77	288.0	COG5652@1|root,COG5652@2|Bacteria,1MX6C@1224|Proteobacteria,2U18Q@28211|Alphaproteobacteria,4BBZB@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4962)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4962,Hepar_II_III
CMS2_k127_2798753_2	1089553.Tph_c09100	7.553e-95	328.0	COG0407@1|root,COG0407@2|Bacteria,1TRJG@1239|Firmicutes,24B34@186801|Clostridia,42G9W@68295|Thermoanaerobacterales	186801|Clostridia	H	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
CMS2_k127_2798753_10	768710.DesyoDRAFT_1951	2.48e-05	57.0	2CJTW@1|root,33NBH@2|Bacteria,1VM99@1239|Firmicutes,24UVS@186801|Clostridia,26684@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2798753_3	1123248.KB893329_gene4463	7.284e-92	311.0	COG1082@1|root,COG1082@2|Bacteria,4PJ9G@976|Bacteroidetes,1IZP5@117747|Sphingobacteriia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
CMS2_k127_2798753_1	530564.Psta_2420	1.332e-106	360.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_2798753_6	583355.Caka_0473	2.473e-62	238.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Calx-beta,DUF1080,F5_F8_type_C,PA14
CMS2_k127_2798753_7	234267.Acid_5864	2.234e-60	232.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_2798753_9	1120999.JONM01000023_gene3164	9.769e-11	66.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,2VWDY@28216|Betaproteobacteria,2KRZB@206351|Neisseriales	206351|Neisseriales	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
CMS2_k127_2798753_8	644968.DFW101_1423	2.368e-30	134.0	COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,42MX0@68525|delta/epsilon subdivisions,2WM16@28221|Deltaproteobacteria,2M98N@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	PFAM Multi antimicrobial extrusion protein MatE	norM-2	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
CMS2_k127_2802840_4	28042.GU90_17785	2.132e-17	91.0	COG0591@1|root,COG0591@2|Bacteria,2HEKH@201174|Actinobacteria,4DZCV@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
CMS2_k127_2802840_3	1499967.BAYZ01000195_gene3083	9.069e-46	182.0	COG3372@1|root,COG3372@2|Bacteria	2|Bacteria	S	COGs COG3372 conserved	-	-	-	ko:K09744	-	-	-	-	ko00000	-	-	-	DUF790
CMS2_k127_2802840_0	368408.Tpen_1762	2.127e-94	327.0	COG1061@1|root,arCOG00874@2157|Archaea,2XQ1C@28889|Crenarchaeota	28889|Crenarchaeota	K	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,Helicase_C,ResIII
CMS2_k127_2802840_2	266117.Rxyl_0854	2.965e-49	198.0	COG1368@1|root,COG1368@2|Bacteria,2H0EW@201174|Actinobacteria	201174|Actinobacteria	M	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_2802840_1	944565.HMPREF9127_1632	5.25e-87	292.0	COG1301@1|root,COG1301@2|Bacteria,1TP4N@1239|Firmicutes,2494N@186801|Clostridia,22GFE@1570339|Peptoniphilaceae	186801|Clostridia	P	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	dctP	-	-	-	-	-	-	-	-	-	-	-	SDF
CMS2_k127_2828635_7	886293.Sinac_5785	1.364e-37	149.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_2828635_4	247490.KSU1_C1120	1.366e-70	249.0	COG0289@1|root,COG0289@2|Bacteria,2IX9G@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
CMS2_k127_2828635_1	1142394.PSMK_13860	8.26e-148	479.0	COG0195@1|root,COG0195@2|Bacteria,2IWY3@203682|Planctomycetes	203682|Planctomycetes	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
CMS2_k127_2828635_0	237368.SCABRO_03706	2.306e-177	589.0	COG0532@1|root,COG0532@2|Bacteria,2IXYU@203682|Planctomycetes	203682|Planctomycetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
CMS2_k127_2828635_14	1382356.JQMP01000003_gene2500	2.753e-09	65.0	COG0858@1|root,COG0858@2|Bacteria,2G73E@200795|Chloroflexi,27YJU@189775|Thermomicrobia	189775|Thermomicrobia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
CMS2_k127_2828635_11	886293.Sinac_5501	9.74e-15	83.0	COG0177@1|root,COG0177@2|Bacteria,2IZDJ@203682|Planctomycetes	203682|Planctomycetes	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	-	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
CMS2_k127_2828635_3	756272.Plabr_1918	3.355e-104	348.0	COG0040@1|root,COG0040@2|Bacteria,2IXEV@203682|Planctomycetes	203682|Planctomycetes	F	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
CMS2_k127_2828635_12	880073.Calab_0691	8.904e-10	71.0	COG0760@1|root,COG0760@2|Bacteria,2NR9Y@2323|unclassified Bacteria	2|Bacteria	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769,ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	OmpA,Rotamase,Rotamase_2,Rotamase_3
CMS2_k127_2828635_16	592015.HMPREF1705_01456	0.0002651	53.0	COG0795@1|root,COG0795@2|Bacteria,3TAEU@508458|Synergistetes	508458|Synergistetes	S	Permease, YjgP YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
CMS2_k127_2828635_15	671143.DAMO_0314	4.195e-09	68.0	COG0795@1|root,COG0795@2|Bacteria,2NPHN@2323|unclassified Bacteria	2|Bacteria	S	Permease YjgP YjgQ	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
CMS2_k127_2828635_9	1297742.A176_02488	8.74e-25	118.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40
CMS2_k127_2828635_2	452637.Oter_1389	1.913e-143	505.0	COG0515@1|root,COG0515@2|Bacteria,46VB0@74201|Verrucomicrobia,3K8AK@414999|Opitutae	414999|Opitutae	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_2828635_5	344747.PM8797T_27367	1.004e-58	214.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_2828635_10	1122609.AUGT01000008_gene2868	6.839e-15	89.0	COG0366@1|root,COG0515@1|root,COG2133@1|root,COG3227@1|root,COG4733@1|root,COG0366@2|Bacteria,COG0515@2|Bacteria,COG2133@2|Bacteria,COG3227@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.3	ko:K01178,ko:K14645,ko:K18546	ko00500,ko01100,ko02024,map00500,map01100,map02024	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH15	-	Alpha-amylase,GSDH,He_PIG,PKD,Pro_Al_protease,SLH,Trypsin,fn3
CMS2_k127_2828635_6	1189612.A33Q_2374	3.276e-45	186.0	COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,47N98@768503|Cytophagia	976|Bacteroidetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,Y_Y_Y
CMS2_k127_2828635_8	1396141.BATP01000019_gene1732	1.182e-25	116.0	COG1595@1|root,COG1595@2|Bacteria,46V3P@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
CMS2_k127_2833327_4	1499967.BAYZ01000075_gene2071	1.72e-66	245.0	COG1925@1|root,COG1925@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	-	-	2.7.1.121	ko:K05881	ko00561,map00561	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS-HPr
CMS2_k127_2833327_8	530564.Psta_0119	1.014e-29	126.0	COG0546@1|root,COG0546@2|Bacteria,2J0RU@203682|Planctomycetes	203682|Planctomycetes	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
CMS2_k127_2833327_3	583355.Caka_0413	4.334e-76	265.0	COG0583@1|root,COG0583@2|Bacteria,46SCJ@74201|Verrucomicrobia,3K7FY@414999|Opitutae	414999|Opitutae	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
CMS2_k127_2833327_0	644282.Deba_0692	1.996e-259	807.0	COG2070@1|root,COG2070@2|Bacteria,1QZ4T@1224|Proteobacteria,43CFR@68525|delta/epsilon subdivisions,2X7QT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Conserved region in glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
CMS2_k127_2833327_2	56780.SYN_01476	6.91e-92	312.0	COG2197@1|root,COG2197@2|Bacteria,1Q9SD@1224|Proteobacteria,42NUX@68525|delta/epsilon subdivisions,2WM09@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
CMS2_k127_2833327_7	1047013.AQSP01000091_gene641	8.154e-42	162.0	COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS2_k127_2833327_1	706587.Desti_1918	2.773e-246	774.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	bamH	-	1.12.1.3,1.6.5.3	ko:K00124,ko:K00335,ko:K05587,ko:K18331	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
CMS2_k127_2833327_6	1047013.AQSP01000091_gene643	1.935e-47	179.0	COG3383@1|root,COG3383@2|Bacteria,2NNXH@2323|unclassified Bacteria	2|Bacteria	C	Iron hydrogenase small subunit	-	-	1.12.1.3,1.17.1.9,1.6.5.3	ko:K00123,ko:K00336,ko:K18332	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iHN637.CLJU_RS03470	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_21,Fer4_7,NADH-G_4Fe-4S_3
CMS2_k127_2833327_9	1396141.BATP01000042_gene1918	1.845e-25	116.0	COG4585@1|root,COG4585@2|Bacteria,46UGH@74201|Verrucomicrobia,2IVFF@203494|Verrucomicrobiae	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,HisKA_3
CMS2_k127_2833327_10	661367.LLO_1892	3.683e-20	105.0	COG3250@1|root,COG4733@1|root,COG5492@1|root,COG3250@2|Bacteria,COG4733@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Malectin,fn3
CMS2_k127_2833327_11	1123237.Salmuc_05019	1.567e-05	57.0	COG3420@1|root,COG3420@2|Bacteria,1RGCE@1224|Proteobacteria,2U8N7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF4082
CMS2_k127_2833327_5	314230.DSM3645_10402	3.675e-60	218.0	COG1573@1|root,COG1573@2|Bacteria,2IZ0V@203682|Planctomycetes	203682|Planctomycetes	L	Uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS2_k127_2836311_1	589865.DaAHT2_0880	2.528e-85	291.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MN5K@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
CMS2_k127_2836311_5	1278307.KB906968_gene2032	2.382e-27	111.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SWYU@1236|Gammaproteobacteria,2QJ81@267894|Psychromonadaceae	1236|Gammaproteobacteria	K	Ribonuclease B OB domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CMS2_k127_2836311_3	926560.KE387023_gene3366	9.728e-30	138.0	COG2133@1|root,COG4733@1|root,COG5563@1|root,COG2133@2|Bacteria,COG4733@2|Bacteria,COG5563@2|Bacteria,1WKZH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Domain of unknown function (DUF1929)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1929,Glyoxal_oxid_N
CMS2_k127_2836311_7	531844.FIC_01763	2.713e-09	71.0	COG1974@1|root,COG3227@1|root,COG5276@1|root,COG1974@2|Bacteria,COG3227@2|Bacteria,COG5276@2|Bacteria,4PHXS@976|Bacteroidetes,1IG6Y@117743|Flavobacteriia,407C0@61432|unclassified Flavobacteriaceae	2|Bacteria	E	repeat protein	umuD	-	3.4.21.88	ko:K01356,ko:K03503	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	HTH_3,Peptidase_S24
CMS2_k127_2836311_4	497964.CfE428DRAFT_5014	1.096e-27	131.0	COG2304@1|root,COG3055@1|root,COG3119@1|root,COG3291@1|root,COG2304@2|Bacteria,COG3055@2|Bacteria,COG3119@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	rapB1	-	3.2.1.4	ko:K01179,ko:K07004,ko:K12548	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Laminin_G_3
CMS2_k127_2836311_2	344747.PM8797T_27367	1.602e-60	215.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_2836311_0	234267.Acid_5676	1.746e-201	669.0	COG0515@1|root,COG1262@1|root,COG1506@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	1.14.99.50,2.7.11.1	ko:K01990,ko:K08884,ko:K12132,ko:K18912	ko00340,map00340	M00254	R11013	RC03323,RC03324	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000	3.A.1	-	-	FGE-sulfatase,Peptidase_S15,Pkinase
CMS2_k127_2836311_8	869210.Marky_1140	0.0002907	53.0	2EQNF@1|root,33I8D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2836311_6	525373.HMPREF0766_12975	7.311e-10	63.0	COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1IPCG@117747|Sphingobacteriia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
CMS2_k127_285555_2	1303518.CCALI_00913	1.394e-13	79.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02679	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_285555_1	333138.LQ50_24845	2.932e-19	96.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HC17@91061|Bacilli,1ZCZ4@1386|Bacillus	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_285555_0	706587.Desti_0179	3.046e-97	325.0	COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria,42NYF@68525|delta/epsilon subdivisions,2WIT2@28221|Deltaproteobacteria,2MQSH@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
CMS2_k127_287833_2	497964.CfE428DRAFT_0890	3.514e-45	172.0	COG0287@1|root,COG0287@2|Bacteria,46SSN@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
CMS2_k127_287833_0	247490.KSU1_D0830	0.0	1064.0	COG0046@1|root,COG0046@2|Bacteria,2IXRT@203682|Planctomycetes	203682|Planctomycetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
CMS2_k127_287833_1	237368.SCABRO_03866	2.874e-61	218.0	COG0047@1|root,COG0047@2|Bacteria,2IYT2@203682|Planctomycetes	203682|Planctomycetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
CMS2_k127_2881504_0	1379698.RBG1_1C00001G0326	7.379e-139	467.0	COG1966@1|root,COG1966@2|Bacteria,2NNP2@2323|unclassified Bacteria	2|Bacteria	T	5TM C-terminal transporter carbon starvation CstA	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
CMS2_k127_2881504_2	1210884.HG799462_gene8990	7.612e-133	436.0	COG1160@1|root,COG1160@2|Bacteria,2IWXY@203682|Planctomycetes	203682|Planctomycetes	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
CMS2_k127_2881504_1	1168034.FH5T_03280	2.12e-133	443.0	COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	dppX	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
CMS2_k127_2881504_4	460265.Mnod_3179	1.694e-52	207.0	COG3534@1|root,COG3534@2|Bacteria,1PPWJ@1224|Proteobacteria,2VFZM@28211|Alphaproteobacteria,1JYY1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
CMS2_k127_2881504_3	1236514.BAKL01000036_gene3027	5.235e-73	256.0	COG5434@1|root,COG5434@2|Bacteria,4NID5@976|Bacteroidetes,2FMZR@200643|Bacteroidia,4AP7B@815|Bacteroidaceae	976|Bacteroidetes	G	Glycosyl hydrolases family 28	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28
CMS2_k127_2900961_6	512565.AMIS_37840	1.068e-12	74.0	COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria,4D8VN@85008|Micromonosporales	201174|Actinobacteria	S	Sulfatase-modifying factor enzyme 1	-	GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005509,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016667,GO:0016670,GO:0018158,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0120147,GO:1901564,GO:1903135	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS2_k127_2900961_2	452637.Oter_3514	1.556e-70	258.0	2F286@1|root,33V6C@2|Bacteria,46V8R@74201|Verrucomicrobia,3K9H5@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2900961_5	552811.Dehly_1102	8.173e-14	79.0	COG1595@1|root,COG1595@2|Bacteria,2G6X7@200795|Chloroflexi,34D3G@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
CMS2_k127_2900961_0	237368.SCABRO_00402	5.692e-302	934.0	COG0488@1|root,COG0488@2|Bacteria,2IWXR@203682|Planctomycetes	203682|Planctomycetes	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
CMS2_k127_2900961_3	177437.HRM2_45140	1.293e-61	226.0	COG1073@1|root,COG1073@2|Bacteria,1NEVB@1224|Proteobacteria,42W4K@68525|delta/epsilon subdivisions,2WRSK@28221|Deltaproteobacteria,2MN89@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2900961_4	596153.Alide_2198	4.328e-17	94.0	COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,2VQPE@28216|Betaproteobacteria,4ADGF@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_2900961_1	118168.MC7420_6675	3.731e-128	435.0	COG2304@1|root,COG2304@2|Bacteria,1GQAG@1117|Cyanobacteria,1H979@1150|Oscillatoriales	1117|Cyanobacteria	T	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
CMS2_k127_2939127_4	573061.Clocel_1808	4.909e-33	138.0	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,36E2W@31979|Clostridiaceae	186801|Clostridia	L	ATP-dependent helicase nuclease subunit A	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
CMS2_k127_2939127_1	477974.Daud_1277	4.55e-167	569.0	COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia,260SC@186807|Peptococcaceae	186801|Clostridia	L	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
CMS2_k127_2939127_5	344747.PM8797T_13248	1.655e-32	142.0	COG4219@1|root,COG4932@1|root,COG4219@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	DUF3738,Peptidase_M56
CMS2_k127_2939127_7	945021.TEH_02270	1.449e-07	55.0	COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,4HNIQ@91061|Bacilli,4B3JK@81852|Enterococcaceae	91061|Bacilli	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
CMS2_k127_2939127_6	391625.PPSIR1_10625	1.094e-27	115.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,42REF@68525|delta/epsilon subdivisions,2WQ4F@28221|Deltaproteobacteria,2YVYH@29|Myxococcales	28221|Deltaproteobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
CMS2_k127_2939127_3	247490.KSU1_C1340	6.676e-107	355.0	COG0016@1|root,COG0016@2|Bacteria,2IXSW@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
CMS2_k127_2939127_0	756272.Plabr_1070	3.752e-206	653.0	COG0657@1|root,COG3119@1|root,COG0657@2|Bacteria,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.1.1.11	ko:K01051	ko00040,ko01100,map00040,map01100	M00081	R02362	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_3,Pectinesterase
CMS2_k127_2939127_2	1122605.KB893625_gene1676	1.999e-149	488.0	COG1621@1|root,COG1621@2|Bacteria,4P0AM@976|Bacteroidetes	976|Bacteroidetes	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2948611_27	290317.Cpha266_1175	6.351e-09	66.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS2_k127_2948611_3	886293.Sinac_1805	1.979e-210	672.0	COG0445@1|root,COG0445@2|Bacteria,2IXGA@203682|Planctomycetes	203682|Planctomycetes	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
CMS2_k127_2948611_17	886293.Sinac_5591	1.453e-30	126.0	COG0736@1|root,COG0736@2|Bacteria,2IZSD@203682|Planctomycetes	203682|Planctomycetes	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
CMS2_k127_2948611_24	481448.Minf_0292	1.961e-15	88.0	COG0760@1|root,COG0760@2|Bacteria,46SU4@74201|Verrucomicrobia,37G1D@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
CMS2_k127_2948611_10	1167006.UWK_01188	4.849e-88	295.0	COG2316@1|root,COG2316@2|Bacteria,1RA50@1224|Proteobacteria,42QZZ@68525|delta/epsilon subdivisions,2WMUN@28221|Deltaproteobacteria,2MJHQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS2_k127_2948611_5	452637.Oter_3704	1.622e-171	549.0	COG3693@1|root,COG3693@2|Bacteria,46UVW@74201|Verrucomicrobia,3K7XQ@414999|Opitutae	2|Bacteria	G	Beta-xylanase	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	CBM_4_9,Glyco_hydro_10
CMS2_k127_2948611_7	143224.JQMD01000002_gene181	1.311e-116	384.0	COG0823@1|root,COG0823@2|Bacteria,4NM2C@976|Bacteroidetes,1I7Q6@117743|Flavobacteriia	976|Bacteroidetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2948611_6	700598.Niako_0747	9.217e-136	443.0	COG0526@1|root,COG1225@1|root,COG0526@2|Bacteria,COG1225@2|Bacteria,4NMEK@976|Bacteroidetes,1IPR4@117747|Sphingobacteriia	976|Bacteroidetes	CO	PFAM Alkyl hydroperoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
CMS2_k127_2948611_15	237368.SCABRO_00944	2.28e-42	158.0	COG3549@1|root,COG3549@2|Bacteria	2|Bacteria	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
CMS2_k127_2948611_14	102125.Xen7305DRAFT_00034050	8.848e-48	172.0	COG3093@1|root,COG3093@2|Bacteria,1G82A@1117|Cyanobacteria,3VN4Y@52604|Pleurocapsales	1117|Cyanobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
CMS2_k127_2948611_9	1210884.HG799468_gene13605	4.192e-90	314.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Polysacc_deac_1,Polysacc_deac_3
CMS2_k127_2948611_1	247490.KSU1_C1126	5.809e-260	842.0	COG1197@1|root,COG1197@2|Bacteria,2IWV4@203682|Planctomycetes	203682|Planctomycetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
CMS2_k127_2948611_0	518766.Rmar_0472	6.865e-262	822.0	COG0021@1|root,COG0021@2|Bacteria,4P14U@976|Bacteroidetes,1FIXF@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Transketolase, thiamine diphosphate binding domain	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
CMS2_k127_2948611_2	583355.Caka_3117	3.276e-229	736.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Beta_helix,DUF1565
CMS2_k127_2948611_8	1449076.JOOE01000004_gene579	8.157e-113	384.0	COG0823@1|root,COG0823@2|Bacteria,1MUK9@1224|Proteobacteria,2UQ6N@28211|Alphaproteobacteria,2K0RY@204457|Sphingomonadales	204457|Sphingomonadales	U	Oligogalacturonate lyase	-	-	4.2.2.6	ko:K01730	ko00040,map00040	-	R04382	RC02124,RC02427	ko00000,ko00001,ko01000	-	-	-	PD40,Pectate_lyase22
CMS2_k127_2948611_16	645991.Sgly_3171	3.818e-34	138.0	COG2941@1|root,COG2941@2|Bacteria,1W24D@1239|Firmicutes,25602@186801|Clostridia,2668T@186807|Peptococcaceae	186801|Clostridia	H	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol	-	-	-	ko:K06134	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R04984,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	-
CMS2_k127_2948611_4	335543.Sfum_2156	9.12e-177	567.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,42U6J@68525|delta/epsilon subdivisions	1224|Proteobacteria	P	PFAM sulfatase	-	-	3.1.6.1,3.1.6.6	ko:K01130,ko:K01133	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Choline_sulf_C,DUF4976,HemolysinCabind,Sulfatase
CMS2_k127_2948611_11	2074.JNYD01000001_gene5835	2.386e-62	226.0	COG1192@1|root,COG1192@2|Bacteria,2GJX3@201174|Actinobacteria,4DXSW@85010|Pseudonocardiales	201174|Actinobacteria	D	involved in chromosome partitioning	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS2_k127_2948611_29	1370121.AUWS01000006_gene5271	5.198e-08	64.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,234JY@1762|Mycobacteriaceae	201174|Actinobacteria	O	serine protease	htrA	GO:0000785,GO:0001101,GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005783,GO:0005789,GO:0005829,GO:0005856,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006915,GO:0006950,GO:0006974,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008219,GO:0008233,GO:0008236,GO:0008630,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009893,GO:0009894,GO:0009898,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010033,GO:0010467,GO:0010506,GO:0010604,GO:0010638,GO:0010646,GO:0010647,GO:0010648,GO:0010821,GO:0010822,GO:0010941,GO:0010942,GO:0010950,GO:0010952,GO:0012501,GO:0012505,GO:0016020,GO:0016021,GO:0016043,GO:0016485,GO:0016540,GO:0016787,GO:0017171,GO:0019222,GO:0019538,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030162,GO:0030163,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031329,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0031984,GO:0032268,GO:0032270,GO:0032526,GO:0032991,GO:0033043,GO:0033554,GO:0033993,GO:0034097,GO:0034599,GO:0034605,GO:0035456,GO:0035458,GO:0035556,GO:0035631,GO:0042175,GO:0042221,GO:0042802,GO:0042981,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043085,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043235,GO:0043280,GO:0043281,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044427,GO:0044429,GO:0044432,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045786,GO:0045862,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051082,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051336,GO:0051345,GO:0051604,GO:0051716,GO:0051726,GO:0052547,GO:0052548,GO:0060255,GO:0060548,GO:0065003,GO:0065007,GO:0065009,GO:0070011,GO:0070013,GO:0070206,GO:0070207,GO:0070848,GO:0070887,GO:0071229,GO:0071300,GO:0071310,GO:0071345,GO:0071363,GO:0071396,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0097190,GO:0097193,GO:0097194,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098802,GO:0098827,GO:0140096,GO:1900407,GO:1900408,GO:1901214,GO:1901215,GO:1901564,GO:1901565,GO:1901575,GO:1901700,GO:1901701,GO:1902175,GO:1902176,GO:1902494,GO:1902531,GO:1902532,GO:1902882,GO:1902883,GO:1903146,GO:1903201,GO:1903202,GO:1905286,GO:1905368,GO:1905369,GO:1905370,GO:2000116,GO:2001056,GO:2001233,GO:2001234,GO:2001235,GO:2001236,GO:2001238,GO:2001239,GO:2001241,GO:2001242,GO:2001243,GO:2001267,GO:2001269	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
CMS2_k127_2948611_23	644283.Micau_3625	2.534e-16	87.0	COG1595@1|root,COG1595@2|Bacteria,2GNZA@201174|Actinobacteria,4DHPG@85008|Micromonosporales	201174|Actinobacteria	K	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF1565,Sigma70_r2
CMS2_k127_2948611_13	575540.Isop_0606	4.815e-50	186.0	COG1413@1|root,COG1413@2|Bacteria,2J0ZX@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_2948611_22	344747.PM8797T_11104	2.207e-21	96.0	COG1551@1|root,COG1551@2|Bacteria,2J0YE@203682|Planctomycetes	203682|Planctomycetes	T	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
CMS2_k127_2948611_26	56110.Oscil6304_2593	1.202e-10	65.0	COG1047@1|root,COG1047@2|Bacteria,1G5R4@1117|Cyanobacteria,1HBDB@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
CMS2_k127_2948611_12	338963.Pcar_1072	5.157e-58	205.0	COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,42RNH@68525|delta/epsilon subdivisions,2X5NY@28221|Deltaproteobacteria,43UM6@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
CMS2_k127_2948611_18	344747.PM8797T_12443	8.184e-27	113.0	COG3682@1|root,COG3682@2|Bacteria,2J12Z@203682|Planctomycetes	203682|Planctomycetes	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS2_k127_2948611_19	344747.PM8797T_12448	2.542e-26	128.0	COG4219@1|root,COG4219@2|Bacteria,2J2SQ@203682|Planctomycetes	203682|Planctomycetes	KT	Antirepressor regulating drug resistance	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
CMS2_k127_2948611_28	215803.DB30_5304	2.226e-08	68.0	COG0457@1|root,COG0457@2|Bacteria,1QX7S@1224|Proteobacteria,43C0S@68525|delta/epsilon subdivisions,2X7BD@28221|Deltaproteobacteria,2YV1Y@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2948611_21	344747.PM8797T_12443	1.682e-22	101.0	COG3682@1|root,COG3682@2|Bacteria,2J12Z@203682|Planctomycetes	203682|Planctomycetes	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS2_k127_2948611_25	861299.J421_1461	4.36e-11	72.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,HEAT_2,Peptidase_M56,Secretin,TonB_C
CMS2_k127_2955808_1	1142394.PSMK_17470	1.486e-113	379.0	COG2204@1|root,COG2204@2|Bacteria,2IWYY@203682|Planctomycetes	203682|Planctomycetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_2955808_8	1121939.L861_08745	1.724e-05	57.0	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	Tad,Tad_C
CMS2_k127_2955808_6	936136.ARRT01000007_gene1088	1.797e-10	69.0	COG1989@1|root,COG1989@2|Bacteria,1PCGH@1224|Proteobacteria,2VA06@28211|Alphaproteobacteria,4BI44@82115|Rhizobiaceae	28211|Alphaproteobacteria	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02278	-	-	-	-	ko00000,ko01000,ko02035,ko02044	-	-	-	Peptidase_A24
CMS2_k127_2955808_5	314230.DSM3645_06434	1.995e-11	74.0	COG4961@1|root,COG4961@2|Bacteria,2J0PV@203682|Planctomycetes	203682|Planctomycetes	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
CMS2_k127_2955808_7	1121422.AUMW01000024_gene249	2.156e-08	66.0	COG3745@1|root,COG3745@2|Bacteria,1V5FZ@1239|Firmicutes,24I7V@186801|Clostridia,262WB@186807|Peptococcaceae	186801|Clostridia	U	Flp pilus assembly protein RcpC/CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
CMS2_k127_2955808_2	247490.KSU1_D0131	1.181e-77	278.0	COG4964@1|root,COG4964@2|Bacteria,2IYI6@203682|Planctomycetes	203682|Planctomycetes	U	Belongs to the GSP D family	-	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Secretin,T2SS-T3SS_pil_N
CMS2_k127_2955808_4	1337093.MBE-LCI_0644	5.043e-19	100.0	COG4963@1|root,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2TUDS@28211|Alphaproteobacteria,2P8H8@245186|Loktanella	28211|Alphaproteobacteria	U	AAA domain	minD	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31
CMS2_k127_2955808_0	338969.Rfer_0799	1.184e-134	440.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2VJWJ@28216|Betaproteobacteria,4ABAY@80864|Comamonadaceae	28216|Betaproteobacteria	U	type II secretion system protein E	cpaF1	-	-	ko:K02283,ko:K20527	ko02024,map02024	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.7.4	-	-	T2SSE
CMS2_k127_296397_2	243090.RB4846	9.008e-13	77.0	COG2864@1|root,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
CMS2_k127_296397_0	1267535.KB906767_gene4433	2.698e-148	482.0	COG1457@1|root,COG1457@2|Bacteria,3Y6MB@57723|Acidobacteria,2JKYN@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the purine-cytosine permease (2.A.39) family	-	-	-	ko:K10974	-	-	-	-	ko00000,ko02000	2.A.39.1	-	-	Transp_cyt_pur
CMS2_k127_296397_1	452637.Oter_3514	1.338e-64	232.0	2F286@1|root,33V6C@2|Bacteria,46V8R@74201|Verrucomicrobia,3K9H5@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_2982415_0	401526.TcarDRAFT_0626	3.26e-96	326.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,4H2S4@909932|Negativicutes	2|Bacteria	C	binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4
CMS2_k127_2982415_2	1408439.JHXW01000012_gene889	2.378e-17	91.0	COG1396@1|root,COG1974@1|root,COG1396@2|Bacteria,COG1974@2|Bacteria,3799F@32066|Fusobacteria	32066|Fusobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Peptidase_S24
CMS2_k127_2982415_1	385682.AFSL01000073_gene1405	4.023e-25	123.0	COG3250@1|root,COG3250@2|Bacteria,4NN59@976|Bacteroidetes,2FQES@200643|Bacteroidia	976|Bacteroidetes	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BetaGal_dom4_5
CMS2_k127_2982415_3	861299.J421_2533	5.286e-15	79.0	COG2096@1|root,COG2096@2|Bacteria,1ZT4I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
CMS2_k127_3000543_1	1122179.KB890438_gene1533	2.371e-91	318.0	COG0574@1|root,COG0574@2|Bacteria,4NH4R@976|Bacteroidetes	976|Bacteroidetes	G	Pyruvate phosphate dikinase	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
CMS2_k127_3000543_0	589865.DaAHT2_0196	1.127e-157	509.0	COG2025@1|root,COG2086@1|root,COG2025@2|Bacteria,COG2086@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria,2MIMG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
CMS2_k127_3012484_2	1142394.PSMK_21370	2.612e-107	354.0	COG0115@1|root,COG0115@2|Bacteria,2IY3N@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CMS2_k127_3012484_3	1210884.HG799465_gene11642	1.147e-53	207.0	COG0142@1|root,COG0142@2|Bacteria,2IXUE@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
CMS2_k127_3012484_7	1280001.BAOA01000105_gene4732	0.0003717	49.0	2AZXR@1|root,31S7H@2|Bacteria,1QJA3@1224|Proteobacteria,1TH8S@1236|Gammaproteobacteria,1XSIN@135623|Vibrionales	135623|Vibrionales	S	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
CMS2_k127_3012484_1	1298920.KI911353_gene69	1.631e-147	481.0	COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,247X2@186801|Clostridia,21Y39@1506553|Lachnoclostridium	186801|Clostridia	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
CMS2_k127_3012484_5	1120973.AQXL01000105_gene2561	3.639e-32	133.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,4HM35@91061|Bacilli,27A2H@186823|Alicyclobacillaceae	91061|Bacilli	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0030272,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
CMS2_k127_3012484_4	1142394.PSMK_18550	8.48e-46	179.0	COG1376@1|root,COG1388@1|root,COG1376@2|Bacteria,COG1388@2|Bacteria,2J0C4@203682|Planctomycetes	203682|Planctomycetes	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,YkuD
CMS2_k127_3012484_0	886293.Sinac_3296	1.291e-165	530.0	COG1219@1|root,COG1219@2|Bacteria,2IXDS@203682|Planctomycetes	203682|Planctomycetes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
CMS2_k127_3012484_6	1122613.ATUP01000002_gene2497	4.49e-19	94.0	COG1595@1|root,COG1595@2|Bacteria,1RD9G@1224|Proteobacteria,2U92K@28211|Alphaproteobacteria,43Y7E@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_3013043_2	644966.Tmar_0354	2.948e-41	157.0	COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,3WCSY@538999|Clostridiales incertae sedis	186801|Clostridia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iHN637.CLJU_RS20420	Mur_ligase_C,Mur_ligase_M
CMS2_k127_3013043_0	861299.J421_5620	4.029e-66	234.0	28J3W@1|root,2Z900@2|Bacteria	2|Bacteria	S	NIPSNAP family containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
CMS2_k127_3013043_3	1260251.SPISAL_00785	1.304e-34	141.0	COG4380@1|root,COG4380@2|Bacteria	2|Bacteria	D	Lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	CsgG,DUF799,Gly-zipper_Omp,NosD,SPOR,TPR_16,TPR_2
CMS2_k127_3013043_4	1121423.JONT01000001_gene2135	4.136e-22	98.0	COG0694@1|root,COG0694@2|Bacteria,1VAAU@1239|Firmicutes,24R29@186801|Clostridia,26375@186807|Peptococcaceae	186801|Clostridia	O	PFAM nitrogen-fixing NifU domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NifU
CMS2_k127_3013043_1	247490.KSU1_C0061	1.422e-62	218.0	COG0182@1|root,COG0182@2|Bacteria,2IWRJ@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
CMS2_k127_303122_4	1499967.BAYZ01000074_gene2175	1.1e-137	447.0	COG4277@1|root,COG4277@2|Bacteria	2|Bacteria	-	-	MA20_15955	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	HHH_3,Radical_SAM
CMS2_k127_303122_11	388467.A19Y_1878	1.942e-16	83.0	COG0398@1|root,COG0398@2|Bacteria,1G3PG@1117|Cyanobacteria,1H98G@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS2_k127_303122_13	411490.ANACAC_02212	1.574e-05	49.0	COG2188@1|root,COG2188@2|Bacteria,1V3D3@1239|Firmicutes,24FYV@186801|Clostridia	186801|Clostridia	K	UTRA	-	-	-	-	-	-	-	-	-	-	-	-	GntR,UTRA
CMS2_k127_303122_5	1267535.KB906767_gene808	3.876e-128	424.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_303122_6	869210.Marky_0745	3.9e-108	365.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,BNR_4
CMS2_k127_303122_2	1178825.ALIH01000004_gene2795	1.962e-150	483.0	COG0673@1|root,COG0673@2|Bacteria,4NJEP@976|Bacteroidetes,1I3KI@117743|Flavobacteriia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_303122_3	595460.RRSWK_04510	1.694e-139	462.0	COG2271@1|root,COG2271@2|Bacteria,2IZ4G@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	ko:K03535	-	-	-	-	ko00000,ko02000	2.A.1.14.1	-	-	MFS_1
CMS2_k127_303122_8	143224.JQMD01000002_gene3084	2.486e-67	237.0	COG1878@1|root,COG1878@2|Bacteria,4NFYB@976|Bacteroidetes,1IIVK@117743|Flavobacteriia	976|Bacteroidetes	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
CMS2_k127_303122_1	1121904.ARBP01000004_gene784	3.438e-161	514.0	COG0473@1|root,COG0473@2|Bacteria,4NEBE@976|Bacteroidetes,47MDN@768503|Cytophagia	976|Bacteroidetes	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CMS2_k127_303122_0	595460.RRSWK_04812	1.375e-279	870.0	COG5492@1|root,COG5492@2|Bacteria,2IYV9@203682|Planctomycetes	203682|Planctomycetes	N	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060
CMS2_k127_303122_7	595460.RRSWK_02091	1.317e-82	293.0	COG1609@1|root,COG4977@1|root,COG1609@2|Bacteria,COG4977@2|Bacteria,2IXTX@203682|Planctomycetes	203682|Planctomycetes	K	Xylose operon regulatory protein	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18,Peripla_BP_3
CMS2_k127_303122_10	1303518.CCALI_02394	3.588e-18	93.0	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_303122_14	530564.Psta_1340	0.0001665	53.0	COG2165@1|root,COG2165@2|Bacteria,2IZ1M@203682|Planctomycetes	203682|Planctomycetes	NU	Protein of unknown function (DUF1559)	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_303122_12	382464.ABSI01000011_gene2466	9.259e-06	59.0	COG2982@1|root,COG3055@1|root,COG3507@1|root,COG4733@1|root,COG2982@2|Bacteria,COG3055@2|Bacteria,COG3507@2|Bacteria,COG4733@2|Bacteria,46W6Z@74201|Verrucomicrobia	2|Bacteria	GMOU	Fibronectin type 3 domain	-	-	1.16.3.3	ko:K22350	-	-	-	-	ko00000,ko01000	-	-	-	AsmA_2,Beta_helix,Big_2,CBM_6,DUF1349,DUF748,GSDH,Glyco_hydro_43,Laminin_G_3,PKD,Phage-tail_3,SLH
CMS2_k127_303122_9	1120998.AUFC01000048_gene3024	1.514e-55	217.0	COG3055@1|root,COG3055@2|Bacteria,1V8SQ@1239|Firmicutes,25BH8@186801|Clostridia	186801|Clostridia	E	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1
CMS2_k127_3043489_5	381764.Fnod_0185	1.758e-14	76.0	COG0622@1|root,COG0622@2|Bacteria,2GD1H@200918|Thermotogae	200918|Thermotogae	S	TIGRFAM phosphodiesterase, MJ0936 family	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
CMS2_k127_3043489_2	1303518.CCALI_02490	6.487e-89	301.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_3043489_3	1499967.BAYZ01000097_gene4355	1.154e-55	203.0	COG2426@1|root,COG2426@2|Bacteria	2|Bacteria	S	small multidrug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
CMS2_k127_3043489_1	742725.HMPREF9450_01363	2.769e-111	379.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,4NMAJ@976|Bacteroidetes,2FNTE@200643|Bacteroidia	976|Bacteroidetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
CMS2_k127_3043489_4	221288.JH992901_gene2266	2.788e-29	125.0	2DP2X@1|root,330AM@2|Bacteria,1GR0E@1117|Cyanobacteria	1117|Cyanobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3043489_0	661478.OP10G_3052	5.936e-116	383.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_304549_0	1123274.KB899432_gene2922	1.969e-262	819.0	COG2759@1|root,COG2759@2|Bacteria,2J5JZ@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
CMS2_k127_304549_2	573413.Spirs_2429	2.302e-134	433.0	COG0190@1|root,COG0190@2|Bacteria,2J5PR@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
CMS2_k127_304549_5	589865.DaAHT2_2043	7.653e-07	56.0	2DCKW@1|root,2ZEJ7@2|Bacteria,1QT5C@1224|Proteobacteria,432QW@68525|delta/epsilon subdivisions,2WY6C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_304549_1	886293.Sinac_3649	1.526e-143	480.0	COG0673@1|root,COG0673@2|Bacteria,2IYHK@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_304549_3	1343739.PAP_00225	1.374e-77	269.0	COG0697@1|root,arCOG00271@2157|Archaea,2XXKE@28890|Euryarchaeota,2434U@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS2_k127_304549_4	1142394.PSMK_04880	2.445e-13	80.0	COG2165@1|root,COG2165@2|Bacteria,2IY1V@203682|Planctomycetes	203682|Planctomycetes	NU	TIGRFAM prepilin-type N-terminal cleavage methylation domain	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_3050702_3	1121468.AUBR01000001_gene516	7.311e-10	63.0	COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,248DZ@186801|Clostridia,42EYM@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Carbon starvation protein CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
CMS2_k127_3050702_1	1142394.PSMK_18500	1.095e-59	216.0	COG1624@1|root,COG1624@2|Bacteria,2IZSP@203682|Planctomycetes	203682|Planctomycetes	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
CMS2_k127_3050702_0	545694.TREPR_1522	1.321e-145	474.0	COG0407@1|root,COG0407@2|Bacteria,2J9RK@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
CMS2_k127_3050702_2	1267533.KB906744_gene89	6.251e-17	89.0	COG3547@1|root,COG3547@2|Bacteria,3Y5SI@57723|Acidobacteria	57723|Acidobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS2_k127_3053436_5	234267.Acid_0302	4.246e-62	223.0	COG0602@1|root,COG0602@2|Bacteria,3Y2UA@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
CMS2_k127_3053436_1	595460.RRSWK_00546	1.182e-140	469.0	COG1082@1|root,COG1082@2|Bacteria,2J24A@203682|Planctomycetes	203682|Planctomycetes	G	Glycosyl-hydrolase 97 N-terminal	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	GH97_C,GH97_N,Glyco_hydro_97
CMS2_k127_3053436_2	1142394.PSMK_22790	1.025e-91	308.0	COG1191@1|root,COG1191@2|Bacteria,2IX9S@203682|Planctomycetes	203682|Planctomycetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS2_k127_3053436_6	1303518.CCALI_00993	2.834e-56	207.0	COG0455@1|root,COG0455@2|Bacteria	2|Bacteria	D	bacterial-type flagellum organization	flhG	-	-	ko:K02282,ko:K04562	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CbiA,ParA
CMS2_k127_3053436_8	1274374.CBLK010000013_gene4243	1.5e-07	58.0	COG0789@1|root,COG0789@2|Bacteria,1VHZ2@1239|Firmicutes,4HMJ6@91061|Bacilli,26Y96@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	cueR	-	-	ko:K11923	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
CMS2_k127_3053436_7	203119.Cthe_1282	7.099e-46	179.0	COG2199@1|root,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,24H33@186801|Clostridia,3WI55@541000|Ruminococcaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS2_k127_3053436_4	886293.Sinac_1531	8.912e-73	254.0	COG0767@1|root,COG0767@2|Bacteria,2IX01@203682|Planctomycetes	203682|Planctomycetes	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
CMS2_k127_3053436_3	436114.SYO3AOP1_0379	1.817e-73	257.0	COG1127@1|root,COG1127@2|Bacteria,2G3WQ@200783|Aquificae	200783|Aquificae	Q	PFAM ABC transporter related	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
CMS2_k127_3053436_0	530564.Psta_2342	9.326e-192	633.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2IWX4@203682|Planctomycetes	203682|Planctomycetes	C	PFAM FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
CMS2_k127_3054914_3	404380.Gbem_3245	2.133e-16	84.0	2CGIS@1|root,2ZFNB@2|Bacteria,1PA8M@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3054914_2	1392486.JIAF01000003_gene722	8.548e-20	106.0	2DKMJ@1|root,309XW@2|Bacteria,4NNRT@976|Bacteroidetes,2FQNM@200643|Bacteroidia	976|Bacteroidetes	S	Peptidase C10 family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I69,Peptidase_C10
CMS2_k127_3054914_1	96561.Dole_1704	5.849e-30	140.0	COG3420@1|root,COG3420@2|Bacteria,1MZHI@1224|Proteobacteria,43BRC@68525|delta/epsilon subdivisions,2WUM4@28221|Deltaproteobacteria,2MN6K@213118|Desulfobacterales	1224|Proteobacteria	P	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3054914_0	509635.N824_22550	2.528e-32	140.0	COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1IPCG@117747|Sphingobacteriia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
CMS2_k127_3056970_16	1089548.KI783301_gene4	1.861e-16	87.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HC17@91061|Bacilli,3WFJ8@539002|Bacillales incertae sedis	91061|Bacilli	K	Sigma-70 region 2	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_3056970_6	420324.KI912037_gene2446	4.56e-35	138.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TS0W@28211|Alphaproteobacteria,1JZHC@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Alanine dehydrogenase/PNT, C-terminal domain	adh	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS2_k127_3056970_24	1303518.CCALI_02493	4.39e-12	76.0	COG4969@1|root,COG4969@2|Bacteria	2|Bacteria	NU	cell adhesion	-	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,SBP_bac_10
CMS2_k127_3056970_22	880073.Calab_0830	1.767e-14	86.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456,ko:K02457,ko:K02458,ko:K02459,ko:K02655,ko:K10926	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	ComP_DUS,N_methyl,T2SSJ
CMS2_k127_3056970_10	1089548.KI783301_gene2047	1.192e-21	111.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.1.1.11	ko:K01051	ko00040,ko01100,map00040,map01100	M00081	R02362	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	CBM_6,Cadherin,DUF1929,HemolysinCabind,Malectin,Metallophos,PA14,Pur_ac_phosph_N
CMS2_k127_3056970_18	595460.RRSWK_06590	8.321e-16	91.0	COG3712@1|root,COG3712@2|Bacteria,2J2V7@203682|Planctomycetes	203682|Planctomycetes	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
CMS2_k127_3056970_8	1210884.HG799464_gene10841	4.621e-29	122.0	COG1595@1|root,COG1595@2|Bacteria,2J0HK@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_3056970_3	886293.Sinac_5728	8.818e-55	212.0	COG2264@1|root,COG2264@2|Bacteria,2J3H0@203682|Planctomycetes	203682|Planctomycetes	J	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
CMS2_k127_3056970_1	118173.KB235914_gene4272	1.175e-94	330.0	COG1524@1|root,COG2931@1|root,COG1524@2|Bacteria,COG2931@2|Bacteria,1G6I0@1117|Cyanobacteria,1HB7N@1150|Oscillatoriales	1117|Cyanobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
CMS2_k127_3056970_12	28444.JODQ01000007_gene5198	7.336e-21	108.0	COG1621@1|root,COG1621@2|Bacteria,2GKT1@201174|Actinobacteria,4EI57@85012|Streptosporangiales	201174|Actinobacteria	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3056970_0	1304885.AUEY01000042_gene3609	5.244e-217	696.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,42PST@68525|delta/epsilon subdivisions,2WJ3A@28221|Deltaproteobacteria,2MIS5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Belongs to the PEP-utilizing enzyme family	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
CMS2_k127_3056970_5	1304275.C41B8_16929	2.03e-44	172.0	COG0671@1|root,COG0671@2|Bacteria,1RGM4@1224|Proteobacteria	1224|Proteobacteria	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
CMS2_k127_3056970_19	375451.RD1_3244	1.168e-15	80.0	2BV7I@1|root,32QM0@2|Bacteria,1Q4QK@1224|Proteobacteria,2VB5R@28211|Alphaproteobacteria,2P44J@2433|Roseobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3056970_28	767817.Desgi_1282	3.181e-09	69.0	COG0663@1|root,COG0663@2|Bacteria,1V6CZ@1239|Firmicutes,24JAK@186801|Clostridia,261VQ@186807|Peptococcaceae	186801|Clostridia	S	Isoleucine patch superfamily enzyme, carbonic anhydrase acetyltransferase	PaaY	-	-	ko:K02617	-	-	-	-	ko00000	-	-	-	Hexapep,Hexapep_2
CMS2_k127_3056970_2	927658.AJUM01000007_gene2722	1.89e-92	336.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9
CMS2_k127_3056970_27	118166.JH976538_gene5060	2.118e-09	61.0	COG2203@1|root,COG4191@1|root,COG5002@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1G07W@1117|Cyanobacteria,1HA9K@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
CMS2_k127_3056970_7	572547.Amico_1870	4.305e-31	128.0	COG2197@1|root,COG2197@2|Bacteria,3TB23@508458|Synergistetes	508458|Synergistetes	K	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS2_k127_3056970_23	570268.ANBB01000050_gene4106	8.347e-14	78.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4EK02@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_3056970_11	243164.DET0169	3.079e-21	102.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_3056970_4	338969.Rfer_1105	2.924e-48	194.0	COG4099@1|root,COG4099@2|Bacteria,1Q9H4@1224|Proteobacteria,2W2SQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2
CMS2_k127_3056970_29	278957.ABEA03000091_gene680	4.582e-05	56.0	COG0457@1|root,COG0457@2|Bacteria	278957.ABEA03000091_gene680|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3056970_25	1419583.V466_17900	6.317e-11	70.0	COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1SASQ@1236|Gammaproteobacteria,1YN9R@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_3056970_15	99598.Cal7507_0109	1.406e-16	87.0	COG1595@1|root,COG1595@2|Bacteria,1G34M@1117|Cyanobacteria,1HP11@1161|Nostocales	1117|Cyanobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_3056970_21	1396141.BATP01000056_gene3251	8.372e-15	81.0	COG1595@1|root,COG1595@2|Bacteria,46VNT@74201|Verrucomicrobia,2IVV9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4
CMS2_k127_3056970_9	886293.Sinac_4705	1.492e-23	116.0	COG2834@1|root,COG2834@2|Bacteria,2J4MG@203682|Planctomycetes	203682|Planctomycetes	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3056970_17	1396141.BATP01000056_gene3251	5.319e-16	85.0	COG1595@1|root,COG1595@2|Bacteria,46VNT@74201|Verrucomicrobia,2IVV9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4
CMS2_k127_3056970_14	1215092.PA6_006_02320	2.528e-17	89.0	COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1SASQ@1236|Gammaproteobacteria,1YCT8@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_3056970_13	1215092.PA6_006_02320	4.024e-20	97.0	COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1SASQ@1236|Gammaproteobacteria,1YCT8@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_3056970_20	1047013.AQSP01000142_gene215	7.969e-15	82.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_3059860_1	452637.Oter_1389	1.04e-111	372.0	COG0515@1|root,COG0515@2|Bacteria,46VB0@74201|Verrucomicrobia,3K8AK@414999|Opitutae	414999|Opitutae	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_3059860_3	344747.PM8797T_27367	3.337e-66	231.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_3059860_2	411902.CLOBOL_07057	3.871e-78	299.0	COG3250@1|root,COG3250@2|Bacteria,1W77V@1239|Firmicutes,25J0P@186801|Clostridia,222YU@1506553|Lachnoclostridium	186801|Clostridia	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
CMS2_k127_3059860_11	1122609.AUGT01000008_gene2868	8.085e-25	122.0	COG0366@1|root,COG0515@1|root,COG2133@1|root,COG3227@1|root,COG4733@1|root,COG0366@2|Bacteria,COG0515@2|Bacteria,COG2133@2|Bacteria,COG3227@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.3	ko:K01178,ko:K14645,ko:K18546	ko00500,ko01100,ko02024,map00500,map01100,map02024	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH15	-	Alpha-amylase,GSDH,He_PIG,PKD,Pro_Al_protease,SLH,Trypsin,fn3
CMS2_k127_3059860_15	1144313.PMI10_04401	3.159e-09	71.0	COG3866@1|root,COG3866@2|Bacteria,4NJUK@976|Bacteroidetes,1IIIB@117743|Flavobacteriia,2NUS2@237|Flavobacterium	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3059860_16	376686.Fjoh_4098	7.225e-09	70.0	COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,1I0G9@117743|Flavobacteriia,2NTFA@237|Flavobacterium	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3059860_10	1396141.BATP01000027_gene1160	8.085e-25	122.0	COG2273@1|root,COG2755@1|root,COG3064@1|root,COG3291@1|root,COG5306@1|root,COG2273@2|Bacteria,COG2755@2|Bacteria,COG3064@2|Bacteria,COG3291@2|Bacteria,COG5306@2|Bacteria,46X9M@74201|Verrucomicrobia,2IV4C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EGM	Peptidase M60-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,M60-like_N,PA14,Peptidase_M60
CMS2_k127_3059860_4	1121438.JNJA01000013_gene89	4.165e-62	220.0	COG0662@1|root,COG0662@2|Bacteria,1RHRM@1224|Proteobacteria,42UA5@68525|delta/epsilon subdivisions,2WQWH@28221|Deltaproteobacteria,2M923@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3059860_5	1095767.CAHD01000030_gene1063	2.782e-58	209.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria,4F201@85016|Cellulomonadaceae	201174|Actinobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
CMS2_k127_3059860_12	203122.Sde_0642	1.292e-16	88.0	COG0659@1|root,COG0659@2|Bacteria	2|Bacteria	P	secondary active sulfate transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	NACHT
CMS2_k127_3059860_0	886293.Sinac_2714	3.066e-146	476.0	COG0673@1|root,COG0673@2|Bacteria,2IXFW@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_3059860_8	563040.Saut_2009	5.831e-30	122.0	COG1708@1|root,COG1708@2|Bacteria,1P703@1224|Proteobacteria,43EBC@68525|delta/epsilon subdivisions,2YSP6@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CMS2_k127_3059860_7	1249480.B649_02665	5.312e-32	130.0	COG2250@1|root,COG2250@2|Bacteria,1NHNT@1224|Proteobacteria,42XN2@68525|delta/epsilon subdivisions,2YS72@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	protein related to C-terminal domain of eukaryotic chaperone, SACSIN	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_3059860_6	311424.DhcVS_1147	5.874e-34	137.0	28MX3@1|root,2ZB49@2|Bacteria,2G9VW@200795|Chloroflexi,34DGX@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3059860_17	1121405.dsmv_1525	9.448e-07	51.0	COG0655@1|root,COG0655@2|Bacteria,1RAK6@1224|Proteobacteria,42QS5@68525|delta/epsilon subdivisions,2WN2M@28221|Deltaproteobacteria,2MJW8@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS2_k127_3059860_19	1242864.D187_005296	0.000695	46.0	2A4D7@1|root,30SZ0@2|Bacteria,1PCIS@1224|Proteobacteria,435DR@68525|delta/epsilon subdivisions,2WZR9@28221|Deltaproteobacteria,2Z2K1@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3059860_18	67315.JOBD01000004_gene5570	0.0002978	51.0	COG0454@1|root,COG0456@2|Bacteria,2INEC@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_3059860_9	449447.MAE_19500	3.239e-25	107.0	COG2929@1|root,COG2929@2|Bacteria	2|Bacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
CMS2_k127_3059860_13	555779.Dthio_PD0702	7.969e-16	80.0	2AM2K@1|root,31BWM@2|Bacteria,1P01P@1224|Proteobacteria,431WI@68525|delta/epsilon subdivisions,2WWXN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	CopG antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	CopG_antitoxin
CMS2_k127_3059860_14	269797.Mbar_A1385	2.679e-14	72.0	COG0655@1|root,arCOG02573@2157|Archaea,2XWPJ@28890|Euryarchaeota,2NAHI@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS2_k127_3062414_2	314230.DSM3645_17685	1.826e-104	347.0	COG0039@1|root,COG0039@2|Bacteria,2IY7S@203682|Planctomycetes	203682|Planctomycetes	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
CMS2_k127_3062414_3	555079.Toce_2047	3.409e-89	322.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,42EMM@68295|Thermoanaerobacterales	186801|Clostridia	C	116 kDa subunit	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
CMS2_k127_3062414_7	929506.CbC4_0827	5.251e-33	133.0	COG0636@1|root,COG0636@2|Bacteria,1V786@1239|Firmicutes,24HBF@186801|Clostridia,36I1J@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the V-ATPase proteolipid subunit family	ntpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
CMS2_k127_3062414_9	885272.JonanDRAFT_0147	1.026e-17	91.0	COG1390@1|root,COG1390@2|Bacteria,3TB57@508458|Synergistetes	508458|Synergistetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
CMS2_k127_3062414_8	580331.Thit_2335	1.507e-21	106.0	COG1527@1|root,COG1527@2|Bacteria,1U6WZ@1239|Firmicutes,249XD@186801|Clostridia,42EZR@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM H -transporting two-sector ATPase, C (AC39) subunit	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
CMS2_k127_3062414_10	1345695.CLSA_c30790	1.26e-05	52.0	COG1436@1|root,COG1436@2|Bacteria,1VAX7@1239|Firmicutes,24MXC@186801|Clostridia,36JRX@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
CMS2_k127_3062414_0	857293.CAAU_0425	6.813e-244	768.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,36DW7@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
CMS2_k127_3062414_1	994573.T472_0215070	4.408e-215	676.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,36DRP@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
CMS2_k127_3062414_6	203119.Cthe_2269	2.181e-47	177.0	COG1394@1|root,COG1394@2|Bacteria,1TQ1Y@1239|Firmicutes,247TC@186801|Clostridia,3WHIG@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
CMS2_k127_3062414_4	1121468.AUBR01000058_gene880	7.469e-55	204.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,42G5U@68295|Thermoanaerobacterales	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
CMS2_k127_3062414_5	234267.Acid_3925	3.682e-48	177.0	COG2309@1|root,COG2309@2|Bacteria,3Y46T@57723|Acidobacteria	57723|Acidobacteria	E	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
CMS2_k127_306509_0	880073.Calab_2105	5.745e-152	500.0	COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria	2|Bacteria	I	Dehydrogenase	acd	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0052890,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.3.8.1,1.3.8.7	ko:K00248,ko:K00249,ko:K20035	ko00071,ko00280,ko00410,ko00640,ko00650,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map00920,map01100,map01110,map01120,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R11130	RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246,RC03363	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
CMS2_k127_306509_1	908612.HMPREF9720_2719	4.707e-102	343.0	COG2025@1|root,COG2025@2|Bacteria,4NFSE@976|Bacteroidetes,2FMEK@200643|Bacteroidia	976|Bacteroidetes	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
CMS2_k127_306509_2	880073.Calab_2103	3.676e-89	302.0	COG2086@1|root,COG2086@2|Bacteria,2NP4J@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
CMS2_k127_3087874_1	1304880.JAGB01000001_gene427	2.235e-129	424.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,24C9J@186801|Clostridia	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
CMS2_k127_3087874_0	1408422.JHYF01000003_gene872	0.0	1157.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,36E0I@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS2_k127_3094518_4	192952.MM_1144	0.0001373	54.0	COG5563@1|root,arCOG03499@1|root,arCOG03499@2157|Archaea,arCOG03501@2157|Archaea	2157|Archaea	S	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Disaggr_assoc,Disaggr_repeat,PKD
CMS2_k127_3094518_3	1121918.ARWE01000001_gene50	2.162e-07	63.0	COG3291@1|root,COG3420@1|root,COG3291@2|Bacteria,COG3420@2|Bacteria,1Q5XI@1224|Proteobacteria,437EC@68525|delta/epsilon subdivisions,2X2KQ@28221|Deltaproteobacteria,43VY4@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3094518_2	1379698.RBG1_1C00001G1862	1.416e-10	76.0	COG1595@1|root,COG1595@2|Bacteria,2NPR9@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70 region 2	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_3094518_0	237368.SCABRO_01252	3.97e-172	561.0	COG1154@1|root,COG1154@2|Bacteria,2IYHC@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
CMS2_k127_3094518_1	1142394.PSMK_14460	2.667e-48	183.0	COG0061@1|root,COG0061@2|Bacteria,2IXD3@203682|Planctomycetes	203682|Planctomycetes	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
CMS2_k127_3119558_3	1396141.BATP01000027_gene1160	1.17e-25	125.0	COG2273@1|root,COG2755@1|root,COG3064@1|root,COG3291@1|root,COG5306@1|root,COG2273@2|Bacteria,COG2755@2|Bacteria,COG3064@2|Bacteria,COG3291@2|Bacteria,COG5306@2|Bacteria,46X9M@74201|Verrucomicrobia,2IV4C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EGM	Peptidase M60-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,M60-like_N,PA14,Peptidase_M60
CMS2_k127_3119558_6	59374.Fisuc_2002	2.611e-07	64.0	COG3866@1|root,COG4733@1|root,COG3866@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Laminin_G_3,fn3
CMS2_k127_3119558_2	1168034.FH5T_08475	2.389e-30	140.0	COG2133@1|root,COG2911@1|root,COG3227@1|root,COG2133@2|Bacteria,COG2911@2|Bacteria,COG3227@2|Bacteria	2|Bacteria	E	Zinc metalloprotease (Elastase)	-	-	-	-	-	-	-	-	-	-	-	-	MAM,PATR,Peptidase_M43,fn3
CMS2_k127_3119558_7	1280380.KR100_07485	0.000148	55.0	COG0265@1|root,COG1262@1|root,COG4412@1|root,COG0265@2|Bacteria,COG1262@2|Bacteria,COG4412@2|Bacteria,1GHF4@1117|Cyanobacteria,1GZ5H@1129|Synechococcus	1117|Cyanobacteria	Q	Tryptophan-rich Synechocystis species C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,W_rich_C
CMS2_k127_3119558_4	886882.PPSC2_c1041	1.157e-10	76.0	COG3250@1|root,COG3408@1|root,COG3533@1|root,COG3250@2|Bacteria,COG3408@2|Bacteria,COG3533@2|Bacteria,1U157@1239|Firmicutes,4HT9T@91061|Bacilli,26UV2@186822|Paenibacillaceae	91061|Bacilli	G	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,Laminin_G_3
CMS2_k127_3119558_5	376686.Fjoh_2456	2.974e-10	74.0	COG3866@1|root,COG3866@2|Bacteria,4NJUK@976|Bacteroidetes,1IIIB@117743|Flavobacteriia,2NUS2@237|Flavobacterium	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3119558_1	203122.Sde_1146	1.131e-31	144.0	COG1664@1|root,COG2133@1|root,COG3343@1|root,COG5276@1|root,COG1664@2|Bacteria,COG2133@2|Bacteria,COG3343@2|Bacteria,COG5276@2|Bacteria,1QUZJ@1224|Proteobacteria,1T318@1236|Gammaproteobacteria,46D2K@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Concanavalin A-like lectin/glucanases superfamily	mshQ	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Bactofilin,H_lectin,Laminin_G_3,PA14
CMS2_k127_3119558_0	1123508.JH636440_gene2887	6.423e-55	199.0	COG0584@1|root,COG0584@2|Bacteria,2IZ1A@203682|Planctomycetes	203682|Planctomycetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS2_k127_3124501_5	269797.Mbar_A2019	1.557e-14	87.0	COG5563@1|root,arCOG03501@2157|Archaea	269797.Mbar_A2019|-	S	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3124501_3	382464.ABSI01000011_gene2441	2.75e-22	113.0	COG1572@1|root,COG3210@1|root,COG1572@2|Bacteria,COG3210@2|Bacteria,46XF9@74201|Verrucomicrobia,2IVRE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	QU	chitinase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3124501_2	96561.Dole_1790	8.423e-36	154.0	COG1319@1|root,COG1653@1|root,COG5492@1|root,COG1319@2|Bacteria,COG1653@2|Bacteria,COG5492@2|Bacteria,1N4S6@1224|Proteobacteria,43BRE@68525|delta/epsilon subdivisions,2X729@28221|Deltaproteobacteria,2MNRP@213118|Desulfobacterales	1224|Proteobacteria	G	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3124501_0	309799.DICTH_0508	2.169e-135	441.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	iLJ478.TM1752	CBM_6,Cellulase
CMS2_k127_3124501_1	909663.KI867150_gene2870	5.24e-63	223.0	arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria,2MRR6@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3124501_6	398767.Glov_2786	1.438e-09	69.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43U5W@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	gnfM	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_3124501_4	1210884.HG799464_gene10830	1.107e-19	95.0	COG0352@1|root,COG0352@2|Bacteria,2IY16@203682|Planctomycetes	203682|Planctomycetes	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Clp_N,TMP-TENI
CMS2_k127_3138199_1	530564.Psta_2678	2.615e-135	440.0	COG4992@1|root,COG4992@2|Bacteria,2IWTF@203682|Planctomycetes	203682|Planctomycetes	E	COG4992 Ornithine acetylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS2_k127_3138199_3	1142394.PSMK_14720	1.751e-94	318.0	COG0548@1|root,COG0548@2|Bacteria,2IWVV@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
CMS2_k127_3138199_5	195253.Syn6312_2673	1.482e-43	166.0	COG0717@1|root,COG0717@2|Bacteria	2|Bacteria	F	dUTP biosynthetic process	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
CMS2_k127_3138199_0	583355.Caka_3039	2.515e-158	520.0	COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,46UC1@74201|Verrucomicrobia,3K9FB@414999|Opitutae	414999|Opitutae	C	TIGRFAM 40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3138199_7	1292035.H476_3569	2.201e-26	126.0	COG3227@1|root,COG4886@1|root,COG3227@2|Bacteria,COG4886@2|Bacteria,1V3UH@1239|Firmicutes,24K2H@186801|Clostridia,25TYN@186804|Peptostreptococcaceae	186801|Clostridia	E	Leucine Rich repeats (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3888,FIVAR,LRR_4
CMS2_k127_3138199_13	247490.KSU1_C1544	0.0003346	53.0	COG2755@1|root,COG5306@1|root,COG2755@2|Bacteria,COG5306@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	exbB2	-	3.4.14.5	ko:K01278,ko:K03561,ko:K12287	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko02044,ko04090,ko04147	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
CMS2_k127_3138199_10	192952.MM_2804	4.892e-12	79.0	arCOG03499@1|root,arCOG03499@2157|Archaea	2157|Archaea	G	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Disaggr_assoc,Disaggr_repeat,PKD
CMS2_k127_3138199_11	192952.MM_1144	4.391e-10	74.0	COG5563@1|root,arCOG03499@1|root,arCOG03499@2157|Archaea,arCOG03501@2157|Archaea	2157|Archaea	S	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Disaggr_assoc,Disaggr_repeat,PKD
CMS2_k127_3138199_8	1121904.ARBP01000011_gene1396	1.223e-20	108.0	COG1404@1|root,COG1572@1|root,COG3291@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,COG3291@2|Bacteria,4NF1M@976|Bacteroidetes,47NC9@768503|Cytophagia	976|Bacteroidetes	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS2_k127_3138199_9	324057.Pjdr2_0818	3.078e-18	100.0	COG3210@1|root,COG4447@1|root,COG3210@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3138199_4	118168.MC7420_6956	1.84e-47	196.0	COG4886@1|root,COG4886@2|Bacteria,1G4SR@1117|Cyanobacteria,1HAQW@1150|Oscillatoriales	1117|Cyanobacteria	G	Leucine-rich repeat	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	LRR_4,LRR_6,LRR_8
CMS2_k127_3138199_6	377629.TERTU_4611	3.394e-43	165.0	COG0454@1|root,COG0456@2|Bacteria,1QU0C@1224|Proteobacteria,1S503@1236|Gammaproteobacteria,2PPW4@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_3138199_2	1499967.BAYZ01000097_gene4350	4.371e-116	387.0	COG4826@1|root,COG4826@2|Bacteria,2NQVB@2323|unclassified Bacteria	2|Bacteria	O	SERine  Proteinase INhibitors	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
CMS2_k127_3138199_12	234267.Acid_2629	1.317e-06	61.0	COG3485@1|root,COG3485@2|Bacteria,3Y9A8@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS2_k127_314042_8	1142394.PSMK_29780	3.255e-65	232.0	COG0515@1|root,COG0515@2|Bacteria,2IZHV@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_314042_10	1142394.PSMK_24810	8.394e-48	182.0	COG0639@1|root,COG0639@2|Bacteria,2IZ5T@203682|Planctomycetes	203682|Planctomycetes	T	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_314042_18	756272.Plabr_1962	7.446e-08	64.0	COG2165@1|root,COG2165@2|Bacteria,2IXWM@203682|Planctomycetes	203682|Planctomycetes	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_314042_12	743836.AYNA01000104_gene2059	1.861e-45	182.0	COG1215@1|root,COG1215@2|Bacteria,1R8UT@1224|Proteobacteria,2TVQT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_transf_21
CMS2_k127_314042_16	682795.AciX8_0482	6.346e-16	86.0	COG1595@1|root,COG1595@2|Bacteria,3Y4CH@57723|Acidobacteria,2JJ6R@204432|Acidobacteriia	204432|Acidobacteriia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_314042_11	1129374.AJE_12598	1.715e-47	176.0	COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,1RQUD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	MgtC SapB transporter	mgtC	GO:0008150,GO:0009405,GO:0044419,GO:0051704	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
CMS2_k127_314042_7	251229.Chro_4749	2.145e-75	270.0	COG0793@1|root,COG0793@2|Bacteria,1G30Q@1117|Cyanobacteria,3VMBN@52604|Pleurocapsales	1117|Cyanobacteria	M	Tricorn protease C1 domain	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41,Tricorn_C1
CMS2_k127_314042_4	1410620.SHLA_36c000140	1.478e-85	291.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_314042_1	234267.Acid_3938	2.691e-169	566.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
CMS2_k127_314042_21	1515613.HQ37_01365	5.266e-05	54.0	COG1595@1|root,COG1595@2|Bacteria,4NF93@976|Bacteroidetes,2FNJV@200643|Bacteroidia,22W2N@171551|Porphyromonadaceae	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_314042_15	153721.MYP_244	3.417e-25	121.0	COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NHCE@976|Bacteroidetes,47NZ4@768503|Cytophagia	976|Bacteroidetes	MU	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40
CMS2_k127_314042_17	1122609.AUGT01000008_gene2868	4.37e-13	82.0	COG0366@1|root,COG0515@1|root,COG2133@1|root,COG3227@1|root,COG4733@1|root,COG0366@2|Bacteria,COG0515@2|Bacteria,COG2133@2|Bacteria,COG3227@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.3	ko:K01178,ko:K14645,ko:K18546	ko00500,ko01100,ko02024,map00500,map01100,map02024	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH15	-	Alpha-amylase,GSDH,He_PIG,PKD,Pro_Al_protease,SLH,Trypsin,fn3
CMS2_k127_314042_13	1142394.PSMK_08290	5.789e-45	179.0	COG2199@1|root,COG2199@2|Bacteria	2|Bacteria	T	diguanylate cyclase activity	yeaP	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621	2.7.7.65	ko:K13069	-	-	R08057	-	ko00000,ko01000	-	-	-	GAF,GAF_2,GAF_3,GGDEF
CMS2_k127_314042_0	247490.KSU1_D0387	1.919e-179	570.0	COG0499@1|root,COG0499@2|Bacteria,2IXKQ@203682|Planctomycetes	203682|Planctomycetes	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
CMS2_k127_314042_2	1303518.CCALI_02044	1.499e-142	462.0	2EE91@1|root,3383F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_314042_5	1142394.PSMK_19560	4.198e-85	309.0	COG4972@1|root,COG4972@2|Bacteria,2IWXB@203682|Planctomycetes	203682|Planctomycetes	NU	TIGRFAM type IV pilus assembly protein PilM	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
CMS2_k127_314042_6	574087.Acear_0608	1.788e-84	297.0	COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,3WA9S@53433|Halanaerobiales	186801|Clostridia	J	MiaB-like tRNA modifying enzyme	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
CMS2_k127_314042_9	344747.PM8797T_27367	2.164e-63	225.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_314042_3	452637.Oter_1389	3.429e-140	476.0	COG0515@1|root,COG0515@2|Bacteria,46VB0@74201|Verrucomicrobia,3K8AK@414999|Opitutae	414999|Opitutae	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_314042_14	485917.Phep_2066	2.109e-37	163.0	COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1IPCG@117747|Sphingobacteriia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
CMS2_k127_314042_19	452471.Aasi_1325	7.665e-08	58.0	COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,47MTM@768503|Cytophagia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
CMS2_k127_3140663_6	526222.Desal_0462	2.22e-19	92.0	COG2006@1|root,COG2006@2|Bacteria,1R9FE@1224|Proteobacteria,42QMT@68525|delta/epsilon subdivisions,2WKDC@28221|Deltaproteobacteria,2MB21@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS2_k127_3140663_1	237368.SCABRO_00125	7.447e-111	362.0	COG1131@1|root,COG1131@2|Bacteria,2IXQV@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_3140663_2	237368.SCABRO_00124	1.577e-108	355.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_5,ABC_transp_aux
CMS2_k127_3140663_0	237368.SCABRO_00123	3.504e-273	855.0	COG3225@1|root,COG3225@2|Bacteria,2IXSG@203682|Planctomycetes	203682|Planctomycetes	N	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_5,ABC_transp_aux
CMS2_k127_3140663_4	97139.C824_02490	7.235e-56	202.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia,36I3Z@31979|Clostridiaceae	186801|Clostridia	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_3140663_5	247490.KSU1_D0829	2.63e-27	112.0	COG0047@1|root,COG0047@2|Bacteria,2IYT2@203682|Planctomycetes	203682|Planctomycetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
CMS2_k127_3148365_21	688269.Theth_0168	0.0003572	53.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS2_k127_3148365_3	314230.DSM3645_10902	3.195e-262	828.0	COG0823@1|root,COG1506@1|root,COG4805@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,COG4805@2|Bacteria,2IY8M@203682|Planctomycetes	203682|Planctomycetes	E	Dipeptidyl peptidase IV (DPP IV)	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,DUF885,Peptidase_S9,VHL
CMS2_k127_3148365_7	160799.PBOR_29415	1.764e-194	638.0	COG3534@1|root,COG3534@2|Bacteria,1TPG2@1239|Firmicutes,4HER2@91061|Bacilli,26UAZ@186822|Paenibacillaceae	91061|Bacilli	G	Alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-L-AF_C,CBM_4_9
CMS2_k127_3148365_2	682795.AciX8_4155	1.748e-292	924.0	COG3533@1|root,COG3533@2|Bacteria,3Y3WA@57723|Acidobacteria,2JKD6@204432|Acidobacteriia	204432|Acidobacteriia	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
CMS2_k127_3148365_1	682795.AciX8_4783	0.0	1231.0	COG3533@1|root,COG3533@2|Bacteria,3Y7GP@57723|Acidobacteria,2JMSH@204432|Acidobacteriia	204432|Acidobacteriia	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
CMS2_k127_3148365_6	234267.Acid_3246	1.544e-196	626.0	COG0673@1|root,COG0673@2|Bacteria,3Y76D@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_3148365_13	56780.SYN_00850	6.226e-47	177.0	COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,42MYP@68525|delta/epsilon subdivisions,2WKKZ@28221|Deltaproteobacteria,2MRNP@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Domain of unknown function (DUF1956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1956,TetR_N
CMS2_k127_3148365_10	1499967.BAYZ01000151_gene1667	1.271e-107	363.0	COG0845@1|root,COG0845@2|Bacteria,2NP97@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
CMS2_k127_3148365_0	690850.Desaf_3621	0.0	1277.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M7S1@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS2_k127_3148365_9	713586.KB900536_gene701	1.231e-117	397.0	COG1538@1|root,COG1538@2|Bacteria,1R705@1224|Proteobacteria,1S0X1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_3148365_4	237368.SCABRO_03724	1.826e-225	717.0	COG1389@1|root,COG1389@2|Bacteria,2J2A8@203682|Planctomycetes	203682|Planctomycetes	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
CMS2_k127_3148365_8	237368.SCABRO_03725	1.356e-178	565.0	COG1697@1|root,COG1697@2|Bacteria,2J34C@203682|Planctomycetes	203682|Planctomycetes	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
CMS2_k127_3148365_19	1380391.JIAS01000013_gene3498	2.329e-05	52.0	COG3468@1|root,COG4447@1|root,COG3468@2|Bacteria,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,2V8XE@28211|Alphaproteobacteria,2JXR9@204441|Rhodospirillales	204441|Rhodospirillales	MU	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3148365_17	234267.Acid_6615	1.222e-13	81.0	28KX8@1|root,2ZAD8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3148365_15	1303518.CCALI_02737	9.156e-23	115.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.78	ko:K19355	ko00051,map00051	-	R01332	RC00467	ko00000,ko00001,ko01000	-	-	-	Cellulase,DUF5060
CMS2_k127_3148365_16	498211.CJA_2517	6.713e-19	102.0	COG3343@1|root,COG3343@2|Bacteria,1QX02@1224|Proteobacteria	1224|Proteobacteria	K	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3148365_11	1347342.BN863_6710	4.141e-62	221.0	COG0791@1|root,COG0791@2|Bacteria,4PM8G@976|Bacteroidetes,1IKC6@117743|Flavobacteriia	976|Bacteroidetes	M	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
CMS2_k127_3148365_12	886293.Sinac_5240	1.078e-58	209.0	COG1506@1|root,COG1506@2|Bacteria,2IWTJ@203682|Planctomycetes	203682|Planctomycetes	E	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
CMS2_k127_3148365_20	344747.PM8797T_13093	0.0001485	45.0	COG1506@1|root,COG1506@2|Bacteria,2IWTJ@203682|Planctomycetes	203682|Planctomycetes	E	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
CMS2_k127_3148365_5	926556.Echvi_2701	5.239e-217	686.0	COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3148365_14	714943.Mucpa_6599	1.421e-26	127.0	COG3507@1|root,COG3507@2|Bacteria,4NI92@976|Bacteroidetes,1ISQE@117747|Sphingobacteriia	976|Bacteroidetes	G	Coagulation factor 5 8 type, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Glyco_hydro_43,Laminin_G_3
CMS2_k127_3148365_18	595460.RRSWK_06590	4.184e-06	54.0	COG3712@1|root,COG3712@2|Bacteria,2J2V7@203682|Planctomycetes	203682|Planctomycetes	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
CMS2_k127_315974_1	1211813.CAPH01000017_gene773	4.78e-249	793.0	COG3408@1|root,COG3408@2|Bacteria,4P4HZ@976|Bacteroidetes	976|Bacteroidetes	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_315974_9	870187.Thini_0548	3.675e-70	260.0	COG1572@1|root,COG1572@2|Bacteria,1N4MI@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4091)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4091
CMS2_k127_315974_14	545695.TREAZ_2549	8.808e-08	65.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_315974_7	357276.EL88_00435	4.72e-79	289.0	COG1397@1|root,COG1397@2|Bacteria,4NG36@976|Bacteroidetes,2FNB7@200643|Bacteroidia,4AM78@815|Bacteroidaceae	976|Bacteroidetes	O	COG NOG08360 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
CMS2_k127_315974_12	1235803.C825_04029	9.407e-61	221.0	COG0667@1|root,COG0667@2|Bacteria,4NP8D@976|Bacteroidetes,2FTGW@200643|Bacteroidia	976|Bacteroidetes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS2_k127_315974_13	1449063.JMLS01000037_gene1759	4.396e-43	181.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,DUF4241
CMS2_k127_315974_5	344747.PM8797T_17127	2.367e-84	310.0	COG1413@1|root,COG1413@2|Bacteria,2IYWU@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_315974_11	1123248.KB893359_gene2089	2.464e-63	246.0	COG2133@1|root,COG2133@2|Bacteria,4PIUD@976|Bacteroidetes,1IXS9@117747|Sphingobacteriia	976|Bacteroidetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS2_k127_315974_4	1168034.FH5T_17250	7.08e-119	397.0	COG0477@1|root,COG2814@2|Bacteria,4PKJD@976|Bacteroidetes,2G0H0@200643|Bacteroidia	976|Bacteroidetes	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	Nuc_H_symport
CMS2_k127_315974_2	720554.Clocl_2886	2.308e-169	542.0	COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,3WHC9@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the aspartokinase family	thrA	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
CMS2_k127_315974_6	1210884.HG799464_gene10481	1.742e-81	283.0	COG3618@1|root,COG3618@2|Bacteria,2IXC5@203682|Planctomycetes	203682|Planctomycetes	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
CMS2_k127_315974_3	509191.AEDB02000022_gene2935	2.565e-119	401.0	COG2006@1|root,COG2006@2|Bacteria,1VRZ8@1239|Firmicutes,24Z9V@186801|Clostridia,3WN5G@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Dockerin_1
CMS2_k127_315974_10	391625.PPSIR1_33651	2.497e-65	230.0	COG3417@1|root,COG3417@2|Bacteria,1RA6V@1224|Proteobacteria,42UKY@68525|delta/epsilon subdivisions,2WR6E@28221|Deltaproteobacteria,2YW6R@29|Myxococcales	28221|Deltaproteobacteria	M	Collagen-binding surface adhesin SpaP (antigen I II family)	-	-	-	ko:K07337	-	-	-	-	ko00000	-	-	-	LpoB
CMS2_k127_315974_8	1192034.CAP_9042	2.607e-74	267.0	COG3014@1|root,COG3014@2|Bacteria,1PD4S@1224|Proteobacteria,42V8Q@68525|delta/epsilon subdivisions,2WRSG@28221|Deltaproteobacteria,2YW0X@29|Myxococcales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K09859	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_315974_0	382464.ABSI01000005_gene985	3.341e-315	992.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
CMS2_k127_3160358_4	747365.Thena_1776	7.721e-12	69.0	COG3937@1|root,COG3937@2|Bacteria,1VK6K@1239|Firmicutes,25JK4@186801|Clostridia,42HH4@68295|Thermoanaerobacterales	186801|Clostridia	S	granule-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3160358_1	1121918.ARWE01000001_gene2051	3.38e-126	423.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,43S4A@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
CMS2_k127_3160358_2	903818.KI912268_gene2726	3.436e-23	104.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	HEPN,NTP_transf_2
CMS2_k127_3160358_0	247490.KSU1_C1712	8.074e-132	439.0	2DBP2@1|root,2ZA71@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3160358_3	1403819.BATR01000018_gene593	3.565e-15	89.0	COG1680@1|root,COG5297@1|root,COG1680@2|Bacteria,COG5297@2|Bacteria,46TK0@74201|Verrucomicrobia,2IVMJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Protein of unknown function (DUF1593)	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1593
CMS2_k127_3180299_4	269797.Mbar_A0724	4.226e-08	66.0	arCOG02527@1|root,arCOG03991@1|root,arCOG02527@2157|Archaea,arCOG03991@2157|Archaea,2XYVG@28890|Euryarchaeota	28890|Euryarchaeota	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
CMS2_k127_3180299_3	457570.Nther_0354	8.279e-16	92.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Beta_helix
CMS2_k127_3180299_2	96561.Dole_1704	1.586e-35	158.0	COG3420@1|root,COG3420@2|Bacteria,1MZHI@1224|Proteobacteria,43BRC@68525|delta/epsilon subdivisions,2WUM4@28221|Deltaproteobacteria,2MN6K@213118|Desulfobacterales	1224|Proteobacteria	P	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3180299_0	344747.PM8797T_29862	2.04e-76	268.0	COG1082@1|root,COG1082@2|Bacteria,2J0ZG@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_3180299_1	1142394.PSMK_14770	2.239e-68	246.0	COG1560@1|root,COG1560@2|Bacteria,2IY7N@203682|Planctomycetes	203682|Planctomycetes	M	Lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
CMS2_k127_3180299_5	1035197.HMPREF9999_00700	1.239e-06	52.0	COG2755@1|root,COG2755@2|Bacteria,4NK31@976|Bacteroidetes,2G3HM@200643|Bacteroidia,1WDUG@1283313|Alloprevotella	976|Bacteroidetes	E	Pfam:DUF303	estS	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	Lipase_GDSL_2,SASA
CMS2_k127_3190924_2	1121101.HMPREF1532_00978	5.477e-07	63.0	COG3119@1|root,COG3866@1|root,COG3119@2|Bacteria,COG3866@2|Bacteria,4NJUK@976|Bacteroidetes,2FR5P@200643|Bacteroidia,4ATC8@815|Bacteroidaceae	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3190924_1	13035.Dacsa_2125	4.794e-36	158.0	COG1028@1|root,COG2931@1|root,COG5306@1|root,COG1028@2|Bacteria,COG2931@2|Bacteria,COG5306@2|Bacteria,1G2IN@1117|Cyanobacteria	1117|Cyanobacteria	IQ	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3190924_0	661478.OP10G_1273	8.558e-158	509.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,Lyase_8,Lyase_8_C,Lyase_8_N,NPCBM_assoc
CMS2_k127_319932_2	435591.BDI_2467	3.333e-59	216.0	COG5434@1|root,COG5434@2|Bacteria,4NFSC@976|Bacteroidetes,2FNQN@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28,Pectate_lyase_3
CMS2_k127_319932_3	314230.DSM3645_17700	3.496e-56	201.0	COG1943@1|root,COG1943@2|Bacteria,2J083@203682|Planctomycetes	203682|Planctomycetes	L	COG1943 Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
CMS2_k127_319932_0	314282.PCNPT3_07895	5.68e-140	469.0	COG4146@1|root,COG4146@2|Bacteria,1MXWV@1224|Proteobacteria,1RR4S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	sglT	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_319932_1	344747.PM8797T_27367	2.806e-68	237.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_319932_4	452637.Oter_4175	3.046e-20	94.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,46VB0@74201|Verrucomicrobia,3K8AK@414999|Opitutae	414999|Opitutae	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_3204722_4	1142394.PSMK_30050	2.673e-131	427.0	COG1217@1|root,COG1217@2|Bacteria,2IY3Q@203682|Planctomycetes	203682|Planctomycetes	T	membrane GTPase involved in stress response	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
CMS2_k127_3204722_2	665571.STHERM_c13210	3.851e-183	590.0	COG3604@1|root,COG3604@2|Bacteria,2J5TK@203691|Spirochaetes	203691|Spirochaetes	KT	Fis Family	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
CMS2_k127_3204722_13	644282.Deba_1149	3.297e-32	139.0	2BCS0@1|root,303C3@2|Bacteria,1N7SU@1224|Proteobacteria,42WF2@68525|delta/epsilon subdivisions,2WR6I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
CMS2_k127_3204722_3	760568.Desku_3348	2.011e-167	537.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,2603A@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM Ammonium transporter	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
CMS2_k127_3204722_10	56780.SYN_02212	6.111e-38	145.0	COG0347@1|root,COG0347@2|Bacteria,1RKRK@1224|Proteobacteria,42T3E@68525|delta/epsilon subdivisions,2WPAT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
CMS2_k127_3204722_0	344747.PM8797T_23786	3.289e-220	694.0	COG0174@1|root,COG0174@2|Bacteria,2IXHM@203682|Planctomycetes	203682|Planctomycetes	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
CMS2_k127_3204722_8	1049564.TevJSym_aa00830	6.357e-43	164.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,1S5B7@1236|Gammaproteobacteria,1J71P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
CMS2_k127_3204722_17	204669.Acid345_0126	5.62e-10	63.0	COG0580@1|root,COG0580@2|Bacteria,3Y3SK@57723|Acidobacteria,2JHX3@204432|Acidobacteriia	204432|Acidobacteriia	G	Major intrinsic protein	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
CMS2_k127_3204722_12	1232410.KI421428_gene1029	9.271e-33	140.0	COG3137@1|root,COG3137@2|Bacteria,1RHDT@1224|Proteobacteria,42XQR@68525|delta/epsilon subdivisions,2X2FN@28221|Deltaproteobacteria,43V6S@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
CMS2_k127_3204722_9	1045855.DSC_03610	3.245e-38	146.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,1X701@135614|Xanthomonadales	135614|Xanthomonadales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
CMS2_k127_3204722_6	1303518.CCALI_02578	9.817e-101	342.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_3204722_7	457421.CBFG_02778	3.782e-43	176.0	COG4733@1|root,COG4733@2|Bacteria,1UI04@1239|Firmicutes,25E8W@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
CMS2_k127_3204722_15	1248232.BANQ01000136_gene1014	1.499e-23	113.0	2DBFB@1|root,2Z8XA@2|Bacteria,1MVTN@1224|Proteobacteria,1RM97@1236|Gammaproteobacteria,1XUIN@135623|Vibrionales	135623|Vibrionales	S	Protein of unknown function (DUF4056)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4056
CMS2_k127_3204722_14	272559.BF9343_0824	4.144e-24	119.0	2DBP6@1|root,2ZA7R@2|Bacteria,4NKM4@976|Bacteroidetes,2FQA8@200643|Bacteroidia,4APXS@815|Bacteroidaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3204722_5	203275.BFO_2603	1.221e-105	362.0	COG0823@1|root,COG0823@2|Bacteria,4NGH4@976|Bacteroidetes,2FN8G@200643|Bacteroidia,22Z72@171551|Porphyromonadaceae	976|Bacteroidetes	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
CMS2_k127_3204722_1	926549.KI421517_gene2473	9.913e-185	590.0	COG3669@1|root,COG3669@2|Bacteria,4NEAP@976|Bacteroidetes,47PH6@768503|Cytophagia	976|Bacteroidetes	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Fucosidase_C
CMS2_k127_3204722_16	1279009.ADICEAN_01159	1.117e-18	102.0	COG2234@1|root,COG2234@2|Bacteria,4NGPJ@976|Bacteroidetes,47NIK@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS2_k127_3204722_11	945713.IALB_2783	6.803e-37	145.0	COG4805@1|root,COG4805@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3257083_6	1499967.BAYZ01000076_gene842	1.79e-15	87.0	COG0457@1|root,COG0457@2|Bacteria,2NQJ6@2323|unclassified Bacteria	2|Bacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
CMS2_k127_3257083_2	56780.SYN_00775	4.813e-38	147.0	COG2197@1|root,COG2197@2|Bacteria,1RARA@1224|Proteobacteria,43B1G@68525|delta/epsilon subdivisions,2X5U5@28221|Deltaproteobacteria,2MRK4@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS2_k127_3257083_0	909663.KI867151_gene3159	1.225e-90	329.0	COG2202@1|root,COG4191@1|root,COG4585@1|root,COG5001@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4585@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	2.7.7.65	ko:K21084	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000	-	-	-	CHASE,GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,SBP_bac_3,dCache_1
CMS2_k127_3257083_4	756067.MicvaDRAFT_2495	2.582e-32	146.0	COG2114@1|root,COG2202@1|root,COG3447@1|root,COG2114@2|Bacteria,COG2202@2|Bacteria,COG3447@2|Bacteria,1FZXP@1117|Cyanobacteria,1HA7X@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,HAMP,MASE1,PAS,dCache_1
CMS2_k127_3257083_5	879212.DespoDRAFT_03175	7.4e-26	117.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,42P4F@68525|delta/epsilon subdivisions,2WJVT@28221|Deltaproteobacteria,2MNQI@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
CMS2_k127_3257083_1	1519464.HY22_03120	4.262e-57	205.0	COG1335@1|root,COG1335@2|Bacteria,1FE0F@1090|Chlorobi	1090|Chlorobi	Q	PFAM isochorismatase hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS2_k127_3257083_3	457570.Nther_1894	7.494e-35	142.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_3257085_0	395495.Lcho_2324	5.543e-31	130.0	2DRHC@1|root,33BRH@2|Bacteria,1NIPF@1224|Proteobacteria,2VXM1@28216|Betaproteobacteria,1KMUW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
CMS2_k127_3257085_3	1297569.MESS2_1300050	5.747e-10	64.0	COG2197@1|root,COG2197@2|Bacteria,1RDI0@1224|Proteobacteria,2U8KR@28211|Alphaproteobacteria,43KXV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
CMS2_k127_3257085_1	288000.BBta_1011	1.09e-21	113.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,2U0F2@28211|Alphaproteobacteria,3JVSC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19
CMS2_k127_3257085_2	1142394.PSMK_03350	2.356e-17	83.0	COG2148@1|root,COG2148@2|Bacteria,2IYWX@203682|Planctomycetes	2|Bacteria	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
CMS2_k127_325828_5	1499967.BAYZ01000161_gene384	2.002e-14	74.0	COG1814@1|root,COG1814@2|Bacteria,2NP4E@2323|unclassified Bacteria	2|Bacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
CMS2_k127_325828_0	1123508.JH636440_gene2620	1.353e-156	513.0	COG0296@1|root,COG0296@2|Bacteria,2IWSC@203682|Planctomycetes	203682|Planctomycetes	G	1,4-alpha-glucan branching enzyme	-	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
CMS2_k127_325828_1	1358423.N180_17220	1.184e-73	266.0	COG2152@1|root,COG2152@2|Bacteria,4NG76@976|Bacteroidetes,1IPYN@117747|Sphingobacteriia	976|Bacteroidetes	G	Glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
CMS2_k127_325828_4	211114.JOEF01000025_gene185	1.277e-44	184.0	COG0491@1|root,COG0491@2|Bacteria,2IBAX@201174|Actinobacteria	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_325828_2	583355.Caka_1736	2.307e-51	197.0	COG2312@1|root,COG2312@2|Bacteria,46TMX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH,LTD
CMS2_k127_325828_6	926550.CLDAP_17510	5.841e-07	57.0	COG5337@1|root,COG5337@2|Bacteria	2|Bacteria	M	Spore coat protein CotH	-	-	-	-	-	-	-	-	-	-	-	-	CotH,LTD
CMS2_k127_3296931_0	382464.ABSI01000013_gene1719	6.452e-138	453.0	COG0673@1|root,COG0673@2|Bacteria,46TK3@74201|Verrucomicrobia,2IVGR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_3296931_1	1047013.AQSP01000115_gene339	1.741e-44	168.0	295NE@1|root,2ZSZT@2|Bacteria	2|Bacteria	S	DoxX	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
CMS2_k127_3296931_2	1267533.KB906735_gene4685	8.545e-38	155.0	COG1063@1|root,COG1063@2|Bacteria,3Y6II@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS2_k127_3296931_4	671143.DAMO_0399	3.866e-10	68.0	COG1708@1|root,COG1708@2|Bacteria,2NS1D@2323|unclassified Bacteria	2|Bacteria	S	Nucleotidyltransferase domain	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
CMS2_k127_3296931_3	1274524.BSONL12_04374	3.986e-20	100.0	2E2AR@1|root,32XG5@2|Bacteria,1VHHN@1239|Firmicutes	1239|Firmicutes	S	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	AP2,HNH_3
CMS2_k127_3296931_5	1396141.BATP01000003_gene4934	6.036e-06	55.0	COG2312@1|root,COG2312@2|Bacteria	2|Bacteria	S	response to antibiotic	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Erythro_esteras,LTD
CMS2_k127_33094_2	886293.Sinac_1624	8.611e-70	246.0	COG0546@1|root,COG0546@2|Bacteria,2IYT6@203682|Planctomycetes	203682|Planctomycetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
CMS2_k127_33094_0	756272.Plabr_0818	8.563e-193	614.0	COG3119@1|root,COG3119@2|Bacteria,2IXMP@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.14	ko:K01137	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078,M00079	R07808,R07819	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4976,Sulfatase
CMS2_k127_33094_1	403833.Pmob_0444	6.276e-102	342.0	COG1028@1|root,COG1028@2|Bacteria,2GDVT@200918|Thermotogae	200918|Thermotogae	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS2_k127_3309510_1	288000.BBta_1040	7.079e-108	372.0	COG3693@1|root,COG3693@2|Bacteria,1QXZM@1224|Proteobacteria,2TXEV@28211|Alphaproteobacteria,3K6U7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	PFAM glycoside hydrolase, family 10	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_cc
CMS2_k127_3309510_3	743299.Acife_1493	1.613e-32	131.0	COG3791@1|root,COG3791@2|Bacteria,1REMP@1224|Proteobacteria,1S3AW@1236|Gammaproteobacteria,2NDXA@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
CMS2_k127_3309510_2	1121904.ARBP01000018_gene2622	6.196e-76	265.0	COG3394@1|root,COG3394@2|Bacteria,4PNAT@976|Bacteroidetes,47TGM@768503|Cytophagia	976|Bacteroidetes	G	YdjC-like protein	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
CMS2_k127_3309510_0	234267.Acid_6145	1.198e-151	493.0	COG0673@1|root,COG0673@2|Bacteria,3Y65Y@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_3309510_4	1303518.CCALI_00862	4.306e-15	85.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02679	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_3309510_5	1303518.CCALI_01222	2.99e-12	77.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_3315821_0	224324.aq_1554	1.144e-107	357.0	COG1830@1|root,COG1830@2|Bacteria,2G3TY@200783|Aquificae	200783|Aquificae	G	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroA'	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
CMS2_k127_3315821_5	1429046.RR21198_4556	3.842e-10	66.0	COG0716@1|root,COG0716@2|Bacteria,2IQZD@201174|Actinobacteria,4G1CN@85025|Nocardiaceae	201174|Actinobacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Flavodoxin_5
CMS2_k127_3315821_2	1185876.BN8_01445	2.618e-49	188.0	COG1680@1|root,COG1680@2|Bacteria,4NGKK@976|Bacteroidetes,47N9R@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471,TPR_2
CMS2_k127_3315821_3	1266925.JHVX01000008_gene327	4.335e-44	174.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2VM3A@28216|Betaproteobacteria,3727A@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
CMS2_k127_3315821_1	555779.Dthio_PD0726	3.084e-53	191.0	2DMID@1|root,32RSF@2|Bacteria,1R0WM@1224|Proteobacteria,43D2G@68525|delta/epsilon subdivisions	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3315821_4	443143.GM18_0490	2.856e-32	127.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,42MR9@68525|delta/epsilon subdivisions,2WIP3@28221|Deltaproteobacteria,43TFR@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	PFAM glycine cleavage system P-protein	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,GDC-P
CMS2_k127_3327666_4	1142394.PSMK_05840	5.336e-73	262.0	COG2812@1|root,COG2812@2|Bacteria,2IX1M@203682|Planctomycetes	203682|Planctomycetes	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
CMS2_k127_3327666_5	595460.RRSWK_04527	3.302e-71	246.0	COG0353@1|root,COG0353@2|Bacteria,2IXK5@203682|Planctomycetes	203682|Planctomycetes	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
CMS2_k127_3327666_2	756272.Plabr_4717	3.082e-104	356.0	COG1508@1|root,COG1508@2|Bacteria,2IXGU@203682|Planctomycetes	203682|Planctomycetes	K	rna polymerase sigma-54 factor	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
CMS2_k127_3327666_0	886293.Sinac_2921	3.382e-109	380.0	COG1132@1|root,COG1132@2|Bacteria,2IXKY@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS2_k127_3327666_3	760568.Desku_0794	3.902e-80	282.0	COG3547@1|root,COG3547@2|Bacteria,1V0B6@1239|Firmicutes,248VY@186801|Clostridia,264BH@186807|Peptococcaceae	186801|Clostridia	L	PFAM Transposase, IS111A IS1328 IS1533	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS2_k127_3327666_8	1094980.Mpsy_3021	1.234e-14	84.0	COG2152@1|root,arCOG04084@2157|Archaea,2XZSX@28890|Euryarchaeota,2NAG0@224756|Methanomicrobia	224756|Methanomicrobia	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
CMS2_k127_3327666_1	265729.GS18_0217625	5.509e-107	355.0	COG4989@1|root,COG4989@2|Bacteria,1TQ12@1239|Firmicutes,4HA57@91061|Bacilli,1ZD8D@1386|Bacillus	91061|Bacilli	S	Oxidoreductase	ycsN	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS2_k127_3327666_6	643648.Slip_0136	9.674e-66	234.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,42JSG@68298|Syntrophomonadaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
CMS2_k127_3327666_10	192952.MM_1119	1.235e-05	58.0	arCOG03500@1|root,arCOG03500@2157|Archaea	2157|Archaea	P	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	Disaggr_assoc
CMS2_k127_3327666_7	96561.Dole_1704	1.586e-19	104.0	COG3420@1|root,COG3420@2|Bacteria,1MZHI@1224|Proteobacteria,43BRC@68525|delta/epsilon subdivisions,2WUM4@28221|Deltaproteobacteria,2MN6K@213118|Desulfobacterales	1224|Proteobacteria	P	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3327666_9	368407.Memar_1213	2.342e-06	61.0	COG3291@1|root,arCOG02527@1|root,arCOG02508@2157|Archaea,arCOG02527@2157|Archaea,2XZJV@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3328739_1	56780.SYN_01451	3.26e-94	315.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,42M44@68525|delta/epsilon subdivisions,2WJFW@28221|Deltaproteobacteria,2MQ9U@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CMS2_k127_3328739_2	891968.Anamo_0082	6.129e-16	80.0	28XQZ@1|root,2ZJMK@2|Bacteria,3TCGY@508458|Synergistetes	508458|Synergistetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3328739_0	926569.ANT_22810	3.824e-113	374.0	COG0588@1|root,COG0588@2|Bacteria,2G822@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
CMS2_k127_3328739_3	886293.Sinac_7208	3.905e-10	70.0	COG2165@1|root,COG2165@2|Bacteria,2IXZK@203682|Planctomycetes	203682|Planctomycetes	NU	TIGRFAM prepilin-type N-terminal cleavage methylation domain	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_3328739_4	1123508.JH636439_gene817	2.587e-08	64.0	COG4968@1|root,COG4968@2|Bacteria,2IZDQ@203682|Planctomycetes	203682|Planctomycetes	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_3331680_11	794903.OPIT5_24060	1.205e-58	213.0	COG0012@1|root,COG0012@2|Bacteria,46UY8@74201|Verrucomicrobia	74201|Verrucomicrobia	J	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3331680_3	344747.PM8797T_26590	1.059e-103	347.0	COG2120@1|root,COG2120@2|Bacteria,2IY80@203682|Planctomycetes	203682|Planctomycetes	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS2_k127_3331680_12	1396141.BATP01000060_gene4765	2.55e-46	193.0	COG0028@1|root,COG2730@1|root,COG2755@1|root,COG2931@1|root,COG3506@1|root,COG3637@1|root,COG4733@1|root,COG5184@1|root,COG0028@2|Bacteria,COG2730@2|Bacteria,COG2755@2|Bacteria,COG2931@2|Bacteria,COG3506@2|Bacteria,COG3637@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,46Z9Q@74201|Verrucomicrobia,2IVEQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	DEGMUZ	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
CMS2_k127_3331680_15	497964.CfE428DRAFT_5014	3.565e-28	134.0	COG2304@1|root,COG3055@1|root,COG3119@1|root,COG3291@1|root,COG2304@2|Bacteria,COG3055@2|Bacteria,COG3119@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	rapB1	-	3.2.1.4	ko:K01179,ko:K07004,ko:K12548	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Laminin_G_3
CMS2_k127_3331680_4	886293.Sinac_3844	1.843e-92	331.0	COG0457@1|root,COG2755@1|root,COG0457@2|Bacteria,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N,Lipase_GDSL_2,SLH,TPR_16,TPR_19,fn3
CMS2_k127_3331680_14	573413.Spirs_0599	6.124e-31	128.0	2B4IF@1|root,31XAC@2|Bacteria,2JAGS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3331680_0	573413.Spirs_0598	7.156e-114	377.0	COG2871@1|root,COG2871@2|Bacteria,2JBKD@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase FAD-binding domain	-	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
CMS2_k127_3331680_8	1408422.JHYF01000002_gene2231	5.943e-68	243.0	COG2209@1|root,COG2209@2|Bacteria,1UYUQ@1239|Firmicutes,24CMI@186801|Clostridia,36RAD@31979|Clostridiaceae	186801|Clostridia	C	Rnf-Nqr subunit, membrane protein	-	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
CMS2_k127_3331680_9	293826.Amet_3188	5.18e-66	232.0	COG1347@1|root,COG1347@2|Bacteria,1UPN4@1239|Firmicutes,25HJG@186801|Clostridia,36QN3@31979|Clostridiaceae	186801|Clostridia	C	Rnf-Nqr subunit, membrane protein	-	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
CMS2_k127_3331680_16	1123274.KB899408_gene3926	2.241e-26	116.0	COG2869@1|root,COG2869@2|Bacteria,2JBGM@203691|Spirochaetes	203691|Spirochaetes	C	FMN_bind	-	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
CMS2_k127_3331680_7	865861.AZSU01000001_gene356	8.219e-73	258.0	COG4658@1|root,COG4658@2|Bacteria,1V08Y@1239|Firmicutes,24DPB@186801|Clostridia,36R19@31979|Clostridiaceae	186801|Clostridia	C	NQR2, RnfD, RnfE family	-	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
CMS2_k127_3331680_19	192952.MM_1144	1.883e-11	77.0	COG5563@1|root,arCOG03499@1|root,arCOG03499@2157|Archaea,arCOG03501@2157|Archaea	2157|Archaea	S	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Disaggr_assoc,Disaggr_repeat,PKD
CMS2_k127_3331680_20	335543.Sfum_1308	1.742e-10	74.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,VWA_2
CMS2_k127_3331680_17	1499967.BAYZ01000161_gene384	2.288e-15	78.0	COG1814@1|root,COG1814@2|Bacteria,2NP4E@2323|unclassified Bacteria	2|Bacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
CMS2_k127_3331680_18	517417.Cpar_0854	1.082e-11	68.0	COG1633@1|root,COG1814@1|root,COG1633@2|Bacteria,COG1814@2|Bacteria,1FEQM@1090|Chlorobi	1090|Chlorobi	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
CMS2_k127_3331680_2	344747.PM8797T_27292	1.308e-104	346.0	COG2133@1|root,COG2133@2|Bacteria,2J53U@203682|Planctomycetes	203682|Planctomycetes	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_3331680_6	264732.Moth_1554	4.366e-74	267.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,42FCP@68295|Thermoanaerobacterales	186801|Clostridia	NU	PFAM Type II secretion system protein E	pilB	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
CMS2_k127_3331680_10	765912.Thimo_2324	2.134e-61	219.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1WXDV@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	ko:K13041	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
CMS2_k127_3331680_5	1380391.JIAS01000020_gene1562	5.141e-77	295.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2JRUC@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
CMS2_k127_3331680_13	402777.KB235903_gene2615	1.663e-35	158.0	COG2203@1|root,COG3829@1|root,COG3920@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG3920@2|Bacteria,1GPXH@1117|Cyanobacteria,1HHTQ@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	ETR1	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,GAF_3,HATPase_c,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9
CMS2_k127_3331680_1	886293.Sinac_5180	1.383e-113	389.0	COG0653@1|root,COG0653@2|Bacteria,2IXIT@203682|Planctomycetes	203682|Planctomycetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
CMS2_k127_3345621_4	234267.Acid_4321	1.698e-36	143.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS2_k127_3345621_3	234267.Acid_4320	2.748e-84	286.0	COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria	57723|Acidobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_3345621_0	1047013.AQSP01000125_gene2637	6.703e-109	395.0	COG0823@1|root,COG4946@1|root,COG0823@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Amidohydro_1,PD40,PG_binding_1,Pkinase,TolB_N
CMS2_k127_3345621_8	547559.Nmag_0561	0.0001204	56.0	COG1506@1|root,arCOG01646@2157|Archaea,2XVEA@28890|Euryarchaeota,23SDU@183963|Halobacteria	183963|Halobacteria	E	Peptidase S9 prolyl oligopeptidase active site	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
CMS2_k127_3345621_7	797304.Natgr_1416	9.145e-05	57.0	COG1506@1|root,arCOG03383@1|root,arCOG01646@2157|Archaea,arCOG03383@2157|Archaea,2XUCV@28890|Euryarchaeota,23RXB@183963|Halobacteria	183963|Halobacteria	E	Peptidase S9 prolyl oligopeptidase active site	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS2_k127_3345621_2	1123242.JH636434_gene5302	1.798e-91	319.0	COG1520@1|root,COG1520@2|Bacteria,2IYRB@203682|Planctomycetes	1123242.JH636434_gene5302|-	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3345621_1	1123242.JH636435_gene2024	1.892e-102	371.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12,TPR_8,WD40
CMS2_k127_3345621_6	1048834.TC41_1897	2.371e-18	96.0	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,4I3EA@91061|Bacilli,279WN@186823|Alicyclobacillaceae	91061|Bacilli	L	Arm DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
CMS2_k127_3358014_0	1089550.ATTH01000001_gene1099	1.739e-21	107.0	COG2911@1|root,COG3210@1|root,COG3250@1|root,COG3420@1|root,COG4412@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG3250@2|Bacteria,COG3420@2|Bacteria,COG4412@2|Bacteria,4PEZ5@976|Bacteroidetes,1FJW1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	U	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,Laminin_G_3
CMS2_k127_3358014_3	247490.KSU1_C1333	0.0005701	51.0	COG4968@1|root,COG4968@2|Bacteria,2J519@203682|Planctomycetes	203682|Planctomycetes	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_3358014_2	237368.SCABRO_03851	4.044e-07	62.0	COG2165@1|root,COG2165@2|Bacteria,2J0Q6@203682|Planctomycetes	203682|Planctomycetes	U	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_3358014_1	1235790.C805_00844	7.441e-19	96.0	2E2AR@1|root,32XG5@2|Bacteria,1VC42@1239|Firmicutes,25DRJ@186801|Clostridia	186801|Clostridia	S	AP2 domain	-	-	-	-	-	-	-	-	-	-	-	-	AP2,HNH_3
CMS2_k127_3381411_0	595460.RRSWK_02560	0.0	1203.0	COG0841@1|root,COG0841@2|Bacteria,2J564@203682|Planctomycetes	2|Bacteria	V	AcrB/AcrD/AcrF family	swrC	-	-	ko:K03296,ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,2.A.6.2	-	-	ACR_tran
CMS2_k127_3381411_2	882378.RBRH_00535	1.355e-127	423.0	COG0308@1|root,COG0308@2|Bacteria,1NQIW@1224|Proteobacteria,2WA6B@28216|Betaproteobacteria,1K252@119060|Burkholderiaceae	28216|Betaproteobacteria	E	beta subunit of N-acylethanolamine-hydrolyzing acid amidase	-	-	-	-	-	-	-	-	-	-	-	-	NAAA-beta,Phospholip_B
CMS2_k127_3381411_9	1499967.BAYZ01000026_gene1612	1.939e-34	138.0	COG1321@1|root,COG1321@2|Bacteria,2NRHI@2323|unclassified Bacteria	2|Bacteria	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
CMS2_k127_3381411_11	909663.KI867150_gene299	8.601e-11	71.0	COG1918@1|root,COG1918@2|Bacteria,1Q2C4@1224|Proteobacteria,437YI@68525|delta/epsilon subdivisions,2X38E@28221|Deltaproteobacteria,2MSDZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	FeoA	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
CMS2_k127_3381411_1	909663.KI867150_gene300	1.299e-272	854.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2MR4V@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
CMS2_k127_3381411_4	760568.Desku_1748	2.63e-107	367.0	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,251A8@186801|Clostridia,264EF@186807|Peptococcaceae	186801|Clostridia	M	PFAM NAD dependent epimerase dehydratase family	capI	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS2_k127_3381411_5	1408473.JHXO01000011_gene3188	2.219e-101	338.0	COG1210@1|root,COG1210@2|Bacteria,4NF1P@976|Bacteroidetes,2FYIC@200643|Bacteroidia	976|Bacteroidetes	GM	Nucleotidyl transferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_N,NTP_transferase
CMS2_k127_3381411_3	1403819.BATR01000092_gene2789	4.748e-125	409.0	COG1577@1|root,COG1577@2|Bacteria,46V85@74201|Verrucomicrobia	74201|Verrucomicrobia	I	mevalonate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GHMP_kinases_C,GHMP_kinases_N
CMS2_k127_3381411_10	886293.Sinac_5046	3.091e-29	124.0	COG0250@1|root,COG0250@2|Bacteria,2J0E8@203682|Planctomycetes	203682|Planctomycetes	K	PFAM Transcription termination factor nusG	-	-	-	ko:K05785	-	-	-	-	ko00000,ko03000	-	-	-	NusG
CMS2_k127_3381411_6	471223.GWCH70_3255	7.516e-72	256.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	ATP-grasp_3,Dala_Dala_lig_C,Dala_Dala_lig_N
CMS2_k127_3381411_7	1142394.PSMK_22380	3.097e-57	214.0	COG0472@1|root,COG0472@2|Bacteria,2IXZQ@203682|Planctomycetes	203682|Planctomycetes	M	UDP-N-acetylmuramyl pentapeptide	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
CMS2_k127_3381411_8	1396418.BATQ01000145_gene3530	4.577e-38	149.0	COG1482@1|root,COG1482@2|Bacteria,46SVM@74201|Verrucomicrobia,2IU31@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Phosphomannose isomerase type I	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
CMS2_k127_3403346_9	1303518.CCALI_00101	6.067e-10	67.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02679	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_3403346_10	235985.BBPN01000006_gene3634	0.0002068	51.0	COG5660@1|root,COG5660@2|Bacteria,2GQSP@201174|Actinobacteria	201174|Actinobacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
CMS2_k127_3403346_8	1206720.BAFQ01000292_gene6322	2.42e-12	76.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4FVYM@85025|Nocardiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_3403346_2	388413.ALPR1_16703	1.987e-109	385.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_3403346_5	886293.Sinac_2713	3.248e-54	216.0	COG3828@1|root,COG3828@2|Bacteria,2IYPM@203682|Planctomycetes	203682|Planctomycetes	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
CMS2_k127_3403346_6	641524.ADICYQ_2261	1.674e-39	169.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
CMS2_k127_3403346_0	497964.CfE428DRAFT_1053	3.806e-234	738.0	COG1574@1|root,COG1574@2|Bacteria,46V0N@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS2_k127_3403346_7	575788.VS_1817	6.828e-33	147.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1983,DUF285,F5_F8_type_C,Peptidase_M60,fn3
CMS2_k127_3403346_1	313628.LNTAR_11691	6.369e-163	553.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_3403346_3	344747.PM8797T_15161	2.04e-106	362.0	COG0673@1|root,COG0673@2|Bacteria,2IXE4@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_3403346_4	1123508.JH636440_gene2112	1.957e-73	260.0	COG1262@1|root,COG1262@2|Bacteria,2IYGB@203682|Planctomycetes	203682|Planctomycetes	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS2_k127_3405370_3	323259.Mhun_1761	3.275e-35	146.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota	28890|Euryarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC-2	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
CMS2_k127_3405370_5	593750.Metfor_0255	1.153e-11	73.0	COG1390@1|root,arCOG00869@2157|Archaea,2Y46J@28890|Euryarchaeota,2NB12@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE-2	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
CMS2_k127_3405370_4	443143.GM18_2448	2.927e-15	80.0	COG0636@1|root,COG0636@2|Bacteria,1N5D3@1224|Proteobacteria,438SF@68525|delta/epsilon subdivisions,2WY87@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM H transporting two-sector ATPase C subunit	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
CMS2_k127_3405370_0	304371.MCP_2293	4.489e-76	280.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,2NAKS@224756|Methanomicrobia	224756|Methanomicrobia	C	V-type ATPase 116kDa subunit family	atpI-2	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
CMS2_k127_3405370_2	909663.KI867150_gene1026	4.924e-55	213.0	COG2202@1|root,COG3829@1|root,COG4585@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4585@2|Bacteria,1N0Y7@1224|Proteobacteria	1224|Proteobacteria	T	PFAM ATP-binding region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,MASE1,PAS
CMS2_k127_3405370_1	452637.Oter_0043	2.718e-70	244.0	COG2197@1|root,COG2197@2|Bacteria,46V5Z@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS2_k127_3424331_2	1319815.HMPREF0202_02654	8.912e-66	232.0	COG2252@1|root,COG2252@2|Bacteria,379KJ@32066|Fusobacteria	32066|Fusobacteria	S	Permease family	-	-	-	-	-	-	-	-	-	-	-	-	Xan_ur_permease
CMS2_k127_3424331_1	1185876.BN8_04516	2.901e-69	245.0	COG0775@1|root,COG0775@2|Bacteria,4NMPF@976|Bacteroidetes,47K2M@768503|Cytophagia	976|Bacteroidetes	F	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
CMS2_k127_3424331_4	1411123.JQNH01000001_gene2315	1.865e-12	70.0	COG1722@1|root,COG1722@2|Bacteria,1PTYQ@1224|Proteobacteria,2UFD6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
CMS2_k127_3424331_0	1345697.M493_12430	2.85e-93	324.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,4HAN2@91061|Bacilli,1WF5P@129337|Geobacillus	91061|Bacilli	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
CMS2_k127_3424331_3	927658.AJUM01000042_gene1500	4.814e-43	173.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF1565,SLH
CMS2_k127_3435507_4	794903.OPIT5_03030	0.000299	52.0	COG1596@1|root,COG1596@2|Bacteria,46YX8@74201|Verrucomicrobia,3K89Y@414999|Opitutae	414999|Opitutae	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
CMS2_k127_3435507_0	373994.Riv7116_5676	8.474e-50	202.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1G4GB@1117|Cyanobacteria,1HKK9@1161|Nostocales	1117|Cyanobacteria	D	PFAM Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,GNVR,ParA,Wzz
CMS2_k127_3435507_1	768671.ThimaDRAFT_0394	2.141e-39	156.0	COG4464@1|root,COG4464@2|Bacteria,1R5E2@1224|Proteobacteria,1S34B@1236|Gammaproteobacteria,1WYWB@135613|Chromatiales	135613|Chromatiales	GM	capsular polysaccharide biosynthesis protein	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
CMS2_k127_3435507_2	1167006.UWK_01809	1.881e-30	140.0	COG0457@1|root,COG3307@1|root,COG0457@2|Bacteria,COG3307@2|Bacteria,1N225@1224|Proteobacteria,42QDQ@68525|delta/epsilon subdivisions,2WM6B@28221|Deltaproteobacteria,2MIM4@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lipid A core-O-antigen ligase-like enyme	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	TPR_14,TPR_16,TPR_8,Wzy_C
CMS2_k127_3435507_5	760192.Halhy_4207	0.000356	53.0	COG3693@1|root,COG3693@2|Bacteria,4NE1E@976|Bacteroidetes,1IV7C@117747|Sphingobacteriia	976|Bacteroidetes	G	SMART glycoside hydrolase family 10	xynA	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	CBM_4_9,Glyco_hydro_10
CMS2_k127_3435507_3	1243664.CAVL020000010_gene4496	2.322e-06	60.0	COG3525@1|root,COG3525@2|Bacteria,1TSQE@1239|Firmicutes	1239|Firmicutes	G	beta-N-acetylglucosaminidase	hyl	-	3.2.1.35	ko:K01197	ko00531,ko01100,map00531,map01100	M00076,M00077	R07824,R07825,R10905	-	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042	-	-	-	F5_F8_type_C,Glyco_hydro_20b,NAGidase
CMS2_k127_343641_14	886293.Sinac_0924	1.672e-43	166.0	COG3119@1|root,COG3119@2|Bacteria,2IWX1@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.8	ko:K01134	ko00600,ko04142,map00600,map04142	-	R04856	RC00231	ko00000,ko00001,ko01000	-	-	-	DUF4994,Sulfatase
CMS2_k127_343641_15	1123242.JH636435_gene1779	3.478e-38	150.0	COG3119@1|root,COG3119@2|Bacteria,2IYFP@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_343641_2	1121859.KB890750_gene214	4.264e-225	707.0	COG3119@1|root,COG3119@2|Bacteria,4NE9D@976|Bacteroidetes,47TZN@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_343641_5	1123508.JH636440_gene2790	1.513e-156	508.0	COG3119@1|root,COG3119@2|Bacteria,2IXUN@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_343641_13	1036674.A28LD_0671	2.326e-59	214.0	2DPEU@1|root,331SS@2|Bacteria,1NDKB@1224|Proteobacteria,1RTE7@1236|Gammaproteobacteria,2QG29@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Golgi phosphoprotein 3 (GPP34)	-	-	-	-	-	-	-	-	-	-	-	-	GPP34
CMS2_k127_343641_23	1403819.BATR01000124_gene4422	0.000842	46.0	COG1520@1|root,COG1520@2|Bacteria,46U6I@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_343641_21	1484460.JSWG01000011_gene1751	6.211e-06	52.0	2ABS3@1|root,3118G@2|Bacteria,4NPFZ@976|Bacteroidetes,1I2IP@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_343641_4	1303518.CCALI_02122	2.963e-159	537.0	2C33Y@1|root,33VR5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_343641_19	203122.Sde_2985	1.74e-09	72.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2
CMS2_k127_343641_18	1303518.CCALI_00484	2.331e-11	74.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02679	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_343641_22	1202532.FF52_17073	7.565e-06	59.0	COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,1I0G9@117743|Flavobacteriia,2NTFA@237|Flavobacterium	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_343641_20	1122921.KB898189_gene614	9.993e-09	69.0	COG3204@1|root,COG3533@1|root,COG3204@2|Bacteria,COG3533@2|Bacteria,1U157@1239|Firmicutes,4HT9T@91061|Bacilli,26UV2@186822|Paenibacillaceae	91061|Bacilli	G	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,Laminin_G_3
CMS2_k127_343641_6	313628.LNTAR_09801	1.268e-155	504.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.1.6.12	ko:K01135,ko:K01138	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00076,M00077	R07823	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
CMS2_k127_343641_9	313628.LNTAR_09771	1.915e-135	451.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_343641_10	471854.Dfer_2051	7.524e-133	442.0	COG3119@1|root,COG3119@2|Bacteria,4NFGI@976|Bacteroidetes,47ND1@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_343641_17	391626.OAN307_c35480	1.377e-21	96.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
CMS2_k127_343641_3	1211114.ALIP01000140_gene2343	1.18e-175	561.0	COG3405@1|root,COG3405@2|Bacteria,1R633@1224|Proteobacteria,1S1FG@1236|Gammaproteobacteria,1X9GN@135614|Xanthomonadales	135614|Xanthomonadales	G	Glycosyl hydrolases family 8	-	-	3.2.1.156	ko:K15531	-	-	-	-	ko00000,ko01000	-	GH8	-	Glyco_hydro_8
CMS2_k127_343641_7	743721.Psesu_1642	2.093e-146	513.0	COG3405@1|root,COG3405@2|Bacteria,1R633@1224|Proteobacteria,1S1FG@1236|Gammaproteobacteria,1X9GN@135614|Xanthomonadales	135614|Xanthomonadales	G	Glycosyl hydrolases family 8	-	-	3.2.1.156	ko:K15531	-	-	-	-	ko00000,ko01000	-	GH8	-	Glyco_hydro_8
CMS2_k127_343641_0	1185876.BN8_04115	0.0	1294.0	2DB7A@1|root,2Z7KK@2|Bacteria,4NGC2@976|Bacteroidetes,47KVX@768503|Cytophagia	976|Bacteroidetes	S	Glycosyl hydrolase family 115	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_115,Glyco_hydro_67N
CMS2_k127_343641_16	1527444.ucyna2_00392	5.598e-24	119.0	COG4354@1|root,COG4354@2|Bacteria,1G17U@1117|Cyanobacteria	1117|Cyanobacteria	G	Bile acid beta-glucosidase	-	-	3.2.1.45	ko:K17108	ko00511,ko00600,ko01100,map00511,map00600,map01100	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH116	-	DUF608,Glyco_hydr_116N
CMS2_k127_343641_12	313589.JNB_18888	2.942e-66	248.0	COG1472@1|root,COG1472@2|Bacteria,2GM43@201174|Actinobacteria,4FE6X@85021|Intrasporangiaceae	201174|Actinobacteria	G	beta-N-acetylhexosaminidase	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3,Glyco_hydro_3_C
CMS2_k127_343641_11	717605.Theco_2601	1.174e-85	297.0	COG0524@1|root,COG0524@2|Bacteria,1TT7Y@1239|Firmicutes,4HC0B@91061|Bacilli,26U8T@186822|Paenibacillaceae	91061|Bacilli	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CMS2_k127_343641_8	1191523.MROS_2495	8.657e-137	445.0	COG3693@1|root,COG3693@2|Bacteria	2|Bacteria	G	endo-1,4-beta-xylanase activity	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_10
CMS2_k127_343641_1	1124780.ANNU01000032_gene1226	5.676e-287	894.0	COG3250@1|root,COG3250@2|Bacteria,4NEDP@976|Bacteroidetes,47JV2@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_2_N,SASA
CMS2_k127_3454527_2	1089553.Tph_c13460	7.348e-66	231.0	COG2110@1|root,COG2110@2|Bacteria,1TPCU@1239|Firmicutes,24ARG@186801|Clostridia,42GU1@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Appr-1-p processing domain protein	ymdB	-	-	-	-	-	-	-	-	-	-	-	Macro
CMS2_k127_3454527_4	688269.Theth_0309	9.681e-15	82.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_3454527_1	344747.PM8797T_11199	4.672e-68	248.0	COG0628@1|root,COG0628@2|Bacteria,2J103@203682|Planctomycetes	203682|Planctomycetes	S	membrane protein-putative a permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CMS2_k127_3454527_3	1123508.JH636443_gene4562	7.746e-35	148.0	COG0164@1|root,COG0164@2|Bacteria,2J4X4@203682|Planctomycetes	203682|Planctomycetes	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3454527_0	886293.Sinac_5445	7.932e-75	258.0	COG0515@1|root,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,TPR_8,WD40
CMS2_k127_3477501_5	290317.Cpha266_0557	1.725e-88	304.0	COG3074@1|root,COG3074@2|Bacteria,1FFHR@1090|Chlorobi	1090|Chlorobi	D	FtsZ-dependent cytokinesis	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3477501_0	765952.PUV_14580	7.869e-309	960.0	COG0365@1|root,COG0365@2|Bacteria,2JFRM@204428|Chlamydiae	204428|Chlamydiae	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
CMS2_k127_3477501_2	1168034.FH5T_20550	1.371e-130	431.0	COG2223@1|root,COG2223@2|Bacteria,4NHX9@976|Bacteroidetes,2FZ04@200643|Bacteroidia	976|Bacteroidetes	P	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
CMS2_k127_3477501_3	909663.KI867150_gene2007	3.03e-89	307.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2MR82@213462|Syntrophobacterales	28221|Deltaproteobacteria	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
CMS2_k127_3477501_1	589865.DaAHT2_1112	1.016e-209	669.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MI87@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3
CMS2_k127_3477501_4	589865.DaAHT2_1111	8.756e-89	299.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
CMS2_k127_3491373_4	1415778.JQMM01000001_gene314	2.05e-64	244.0	COG0657@1|root,COG0657@2|Bacteria,1R4AU@1224|Proteobacteria,1RQMN@1236|Gammaproteobacteria,1J5AK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	COG0657 Esterase lipase	aes	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
CMS2_k127_3491373_5	41431.PCC8801_4097	1.386e-56	220.0	COG0627@1|root,COG0627@2|Bacteria,1GGBS@1117|Cyanobacteria	1117|Cyanobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS2_k127_3491373_3	243090.RB1732	4.534e-86	291.0	COG0388@1|root,COG0388@2|Bacteria,2J3H5@203682|Planctomycetes	203682|Planctomycetes	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
CMS2_k127_3491373_2	1280706.AUJE01000003_gene2156	2.884e-87	305.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,4H2G0@909932|Negativicutes	909932|Negativicutes	S	Flavoprotein family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
CMS2_k127_3491373_1	880073.Calab_0995	3.832e-99	330.0	COG0501@1|root,COG0501@2|Bacteria,2NS4G@2323|unclassified Bacteria	2|Bacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CMS2_k127_3491373_0	237368.SCABRO_00503	9.217e-266	850.0	COG0249@1|root,COG0249@2|Bacteria,2IXGV@203682|Planctomycetes	203682|Planctomycetes	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
CMS2_k127_3491373_10	667014.Thein_1747	7.266e-21	93.0	COG2827@1|root,COG2827@2|Bacteria	2|Bacteria	L	Endonuclease containing a URI domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
CMS2_k127_3491373_7	562970.Btus_3319	7.882e-41	166.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,4HA06@91061|Bacilli,27824@186823|Alicyclobacillaceae	91061|Bacilli	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
CMS2_k127_3491373_6	247490.KSU1_C0153	4.053e-42	164.0	COG1521@1|root,COG1521@2|Bacteria,2J0M0@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
CMS2_k127_3491373_8	1123242.JH636435_gene2480	9.382e-38	153.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_3491373_9	370438.PTH_0833	4.469e-25	108.0	COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,25ZZB@186807|Peptococcaceae	186801|Clostridia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
CMS2_k127_3491373_11	547042.BACCOPRO_00511	3.454e-15	87.0	COG2819@1|root,COG2819@2|Bacteria,4NGJB@976|Bacteroidetes,2FR8R@200643|Bacteroidia,4AQA2@815|Bacteroidaceae	976|Bacteroidetes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS2_k127_3503060_6	1121904.ARBP01000022_gene3520	2.927e-28	120.0	COG1621@1|root,COG1621@2|Bacteria,4PNCP@976|Bacteroidetes	976|Bacteroidetes	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3503060_4	1173026.Glo7428_3803	5.554e-53	200.0	COG1262@1|root,COG1262@2|Bacteria,1G0FF@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
CMS2_k127_3503060_0	452637.Oter_0134	2.215e-220	700.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase,DUF4038,DUF5060,Glyco_hydro_115
CMS2_k127_3503060_3	472759.Nhal_3806	3.171e-83	286.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S0GF@1236|Gammaproteobacteria,1X0AW@135613|Chromatiales	135613|Chromatiales	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
CMS2_k127_3503060_2	742742.HMPREF9452_00221	1.634e-85	295.0	COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4CUIV@84998|Coriobacteriia	84998|Coriobacteriia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
CMS2_k127_3503060_5	706587.Desti_0559	2.008e-43	167.0	COG1225@1|root,COG1225@2|Bacteria,1NZF4@1224|Proteobacteria,42ZRX@68525|delta/epsilon subdivisions	1224|Proteobacteria	O	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3503060_1	575540.Isop_2719	2.327e-95	324.0	COG4956@1|root,COG4956@2|Bacteria,2IXF3@203682|Planctomycetes	203682|Planctomycetes	S	Integral membrane protein (PIN domain superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	PIN_4,TRAM
CMS2_k127_3503060_8	1123278.KB893395_gene5042	3.515e-05	56.0	COG0823@1|root,COG0823@2|Bacteria,4NYAT@976|Bacteroidetes,47Y9Z@768503|Cytophagia	976|Bacteroidetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3503060_7	1121904.ARBP01000025_gene6085	9.383e-12	78.0	COG2273@1|root,COG2730@1|root,COG3291@1|root,COG4733@1|root,COG5184@1|root,COG5492@1|root,COG2273@2|Bacteria,COG2730@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	chiA	-	3.2.1.4,3.2.1.73,3.2.1.80	ko:K01179,ko:K01216,ko:K03332,ko:K20276	ko00051,ko00500,ko01100,ko02024,map00051,map00500,map01100,map02024	-	R00879,R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Big_2,CBM_6,CHU_C,F5_F8_type_C,Glyco_hydro_16,PKD
CMS2_k127_351634_3	1122927.KB895414_gene5100	3.27e-25	108.0	COG1476@1|root,COG1476@2|Bacteria,1VEGF@1239|Firmicutes,4HWXY@91061|Bacilli,2704G@186822|Paenibacillaceae	91061|Bacilli	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
CMS2_k127_351634_0	1396141.BATP01000027_gene1180	2.125e-99	347.0	COG0616@1|root,COG0616@2|Bacteria,46SQ5@74201|Verrucomicrobia,2IUT8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	OU	Serine dehydrogenase proteinase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S49
CMS2_k127_351634_1	344747.PM8797T_13248	1.672e-58	230.0	COG4219@1|root,COG4932@1|root,COG4219@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	DUF3738,Peptidase_M56
CMS2_k127_351634_2	344747.PM8797T_13243	2.302e-43	163.0	COG3682@1|root,COG3682@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS2_k127_3555959_0	886293.Sinac_6825	1.271e-128	421.0	COG3356@1|root,COG3356@2|Bacteria,2IXX5@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
CMS2_k127_3555959_3	1303518.CCALI_01330	1.603e-14	84.0	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_3555959_1	1185876.BN8_04770	2.2e-81	289.0	COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,47K7H@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_3555959_2	1123242.JH636434_gene5340	3.353e-34	148.0	COG1413@1|root,COG1413@2|Bacteria,2IZE1@203682|Planctomycetes	203682|Planctomycetes	C	E-Z type HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
CMS2_k127_3560013_0	344747.PM8797T_32040	1.526e-216	709.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Malectin,PQQ_2,PQQ_3
CMS2_k127_3560013_1	1123508.JH636441_gene3305	1.326e-169	574.0	COG1409@1|root,COG1520@1|root,COG1409@2|Bacteria,COG1520@2|Bacteria,2IXB6@203682|Planctomycetes	203682|Planctomycetes	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Metallophos,Methyltransf_25,PQQ_2
CMS2_k127_3563385_3	1131269.AQVV01000003_gene672	2.741e-109	361.0	COG0119@1|root,COG0119@2|Bacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
CMS2_k127_3563385_6	1336245.JAGO01000011_gene215	1.485e-73	261.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1XH38@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
CMS2_k127_3563385_5	237368.SCABRO_03813	1.048e-92	326.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,2IXKU@203682|Planctomycetes	203682|Planctomycetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroD	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
CMS2_k127_3563385_14	1499967.BAYZ01000049_gene2763	4.93e-09	62.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
CMS2_k127_3563385_10	383372.Rcas_1958	2.716e-35	139.0	COG2250@1|root,COG2250@2|Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_3563385_15	237368.SCABRO_03851	2.905e-06	61.0	COG2165@1|root,COG2165@2|Bacteria,2J0Q6@203682|Planctomycetes	203682|Planctomycetes	U	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_3563385_1	1313304.CALK_1633	2.828e-158	509.0	COG0137@1|root,COG0137@2|Bacteria	2|Bacteria	E	argininosuccinate synthase activity	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.argG,iSB619.SA_RS04675	Arginosuc_synth
CMS2_k127_3563385_8	1142394.PSMK_18480	2.811e-61	227.0	COG1989@1|root,COG1989@2|Bacteria,2IZQ8@203682|Planctomycetes	203682|Planctomycetes	NOU	Bacterial Peptidase A24 N-terminal domain	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
CMS2_k127_3563385_11	247490.KSU1_B0095	1.477e-24	112.0	COG1360@1|root,COG1360@2|Bacteria,2IZSF@203682|Planctomycetes	203682|Planctomycetes	N	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
CMS2_k127_3563385_4	1121104.AQXH01000001_gene1014	3.684e-94	324.0	COG1785@1|root,COG1785@2|Bacteria,4NG3D@976|Bacteroidetes,1IPXF@117747|Sphingobacteriia	976|Bacteroidetes	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
CMS2_k127_3563385_7	314230.DSM3645_19957	2.196e-65	252.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2IY17@203682|Planctomycetes	203682|Planctomycetes	S	competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
CMS2_k127_3563385_13	903818.KI912268_gene2028	3.508e-12	73.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_3563385_0	381764.Fnod_0055	2.998e-192	616.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GC9M@200918|Thermotogae	200918|Thermotogae	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	POR,POR_N
CMS2_k127_3563385_2	868131.MSWAN_0191	4.321e-123	400.0	COG1013@1|root,arCOG01599@2157|Archaea,2XTW2@28890|Euryarchaeota,23PWY@183925|Methanobacteria	183925|Methanobacteria	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
CMS2_k127_3563385_9	886293.Sinac_2536	2.074e-52	196.0	COG1119@1|root,COG1119@2|Bacteria,2J3EX@203682|Planctomycetes	203682|Planctomycetes	P	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS2_k127_3563385_12	933262.AXAM01000063_gene610	4.222e-22	96.0	COG1598@1|root,COG1598@2|Bacteria,1PKQ0@1224|Proteobacteria,438VX@68525|delta/epsilon subdivisions,2X9PU@28221|Deltaproteobacteria,2MPDH@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3574935_0	56780.SYN_02589	0.0	1704.0	COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MQ8X@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0661	CPSase_L_D2,CPSase_L_D3,MGS
CMS2_k127_3590630_1	243231.GSU1728	5.853e-116	385.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2WJ81@28221|Deltaproteobacteria,43T1P@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS2_k127_3590630_2	471874.PROSTU_03153	6.307e-98	332.0	COG0111@1|root,COG0111@2|Bacteria,1N5TD@1224|Proteobacteria,1RMFW@1236|Gammaproteobacteria,3Z77B@586|Providencia	1236|Gammaproteobacteria	H	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate	pdxB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0033711,GO:0034641,GO:0036001,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.1.1.290	ko:K03473	ko00750,ko01100,map00750,map01100	M00124	R04210	RC00084	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z3582	2-Hacid_dh,2-Hacid_dh_C,DUF3410
CMS2_k127_3590630_3	1118235.CAJH01000014_gene860	3.316e-77	267.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1X3ZA@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CMS2_k127_3590630_0	909663.KI867150_gene2628	7.296e-267	845.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MR70@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
CMS2_k127_3590630_4	235909.GK0150	7.231e-24	111.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HC17@91061|Bacilli,1WETT@129337|Geobacillus	91061|Bacilli	K	binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription this protein is involved in detoxification and protection against antimicrobial	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_3590630_5	264732.Moth_1842	0.000986	52.0	COG5662@1|root,COG5662@2|Bacteria,1VKS6@1239|Firmicutes,24VD1@186801|Clostridia	186801|Clostridia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
CMS2_k127_3600026_0	522772.Dacet_0784	1.241e-148	483.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS2_k127_3600026_2	926569.ANT_21930	2.497e-47	180.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	3.2.1.81,3.2.1.97	ko:K01219,ko:K17624	-	-	-	-	ko00000,ko01000	-	GH101	-	Big_2,CBM_6,Cytochrome_C7,F5_F8_type_C,Glyco_hyd_101C,Glyco_hydro_101,WxL
CMS2_k127_3600026_4	1122182.KB903834_gene5736	1.442e-30	127.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4D9I5@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigH	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_3600026_3	1249975.JQLP01000005_gene1651	1.502e-32	145.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP_2,Kelch_1,Laminin_G_3
CMS2_k127_3600026_1	278957.ABEA03000041_gene2050	3.504e-143	483.0	COG5434@1|root,COG5434@2|Bacteria,46U2F@74201|Verrucomicrobia,3K9E5@414999|Opitutae	414999|Opitutae	M	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3606874_5	1296415.JACC01000003_gene2953	3.629e-07	57.0	2ABS3@1|root,3118G@2|Bacteria,4NPFZ@976|Bacteroidetes,1I2IP@117743|Flavobacteriia,2YJI4@290174|Aquimarina	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3606874_4	1237149.C900_01120	8.777e-30	125.0	COG1595@1|root,COG1595@2|Bacteria,4NPMI@976|Bacteroidetes	976|Bacteroidetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_3606874_0	234267.Acid_1336	2.384e-196	621.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,TAT_signal
CMS2_k127_3606874_1	1173028.ANKO01000246_gene4028	1.086e-171	566.0	COG4122@1|root,COG4122@2|Bacteria,1GBCN@1117|Cyanobacteria,1HEQZ@1150|Oscillatoriales	1117|Cyanobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3606874_3	926569.ANT_02630	8.887e-74	259.0	COG0226@1|root,COG0226@2|Bacteria,2G7T2@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
CMS2_k127_3606874_2	1408422.JHYF01000006_gene1211	5.966e-89	301.0	COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia,36HRK@31979|Clostridiaceae	186801|Clostridia	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
CMS2_k127_362200_7	247490.KSU1_D0944	2.827e-33	131.0	COG4992@1|root,COG4992@2|Bacteria,2IWTF@203682|Planctomycetes	203682|Planctomycetes	E	COG4992 Ornithine acetylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS2_k127_362200_2	880073.Calab_0179	1.357e-95	322.0	COG0078@1|root,COG0078@2|Bacteria,2NNWN@2323|unclassified Bacteria	2|Bacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS2_k127_362200_4	936455.KI421499_gene5769	8.854e-70	248.0	COG1525@1|root,COG1525@2|Bacteria,1R7Y7@1224|Proteobacteria,2U2IA@28211|Alphaproteobacteria,3JSDZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Staphylococcal nuclease homologue	-	-	-	-	-	-	-	-	-	-	-	-	SNase
CMS2_k127_362200_9	1123228.AUIH01000060_gene3401	0.0004188	49.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,1RNRG@1236|Gammaproteobacteria,1XQYS@135619|Oceanospirillales	135619|Oceanospirillales	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
CMS2_k127_362200_1	706587.Desti_5055	5.893e-141	465.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria	1224|Proteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Dak2,DegV,Radical_SAM
CMS2_k127_362200_0	1121104.AQXH01000001_gene1902	1.542e-169	550.0	COG2866@1|root,COG2866@2|Bacteria,4NH4I@976|Bacteroidetes	976|Bacteroidetes	E	Peptidase M14	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS2_k127_362200_3	929703.KE386491_gene756	2.019e-82	297.0	COG2866@1|root,COG2866@2|Bacteria,4NHBS@976|Bacteroidetes,47MR4@768503|Cytophagia	976|Bacteroidetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS2_k127_362200_5	269797.Mbar_A0416	2.34e-57	213.0	arCOG03561@1|root,arCOG03561@2157|Archaea,2Y1Q9@28890|Euryarchaeota,2N9M9@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,NHL
CMS2_k127_362200_8	237368.SCABRO_03047	0.0003354	48.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM,SPASM
CMS2_k127_3651974_6	85982.XP_007323108.1	1.716e-08	58.0	COG0457@1|root,KOG1840@2759|Eukaryota,38C2F@33154|Opisthokonta,3NYVZ@4751|Fungi	4751|Fungi	Z	domain) protein	-	-	-	-	-	-	-	-	-	-	-	-	HET,NB-ARC,PNP_UDP_1,TPR_10,TPR_12,TPR_7,TPR_8
CMS2_k127_3651974_7	344747.PM8797T_11439	0.0001145	48.0	COG4974@1|root,COG4974@2|Bacteria,2IXH0@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
CMS2_k127_3651974_5	1174504.AJTN02000006_gene2214	8.49e-17	89.0	2BKUM@1|root,32FB0@2|Bacteria,1U7RG@1239|Firmicutes,4INKC@91061|Bacilli,1ZNMD@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3651974_2	1190603.AJYD01000008_gene2093	1.59e-39	162.0	COG3274@1|root,COG3274@2|Bacteria,1PX98@1224|Proteobacteria,1RMGG@1236|Gammaproteobacteria,1XY9X@135623|Vibrionales	135623|Vibrionales	S	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
CMS2_k127_3651974_4	429009.Adeg_1145	6.093e-29	123.0	COG1853@1|root,COG1853@2|Bacteria,1UVM8@1239|Firmicutes,24IYR@186801|Clostridia,42JA7@68295|Thermoanaerobacterales	186801|Clostridia	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
CMS2_k127_3651974_1	926569.ANT_04550	1.51e-45	175.0	COG2071@1|root,COG2071@2|Bacteria,2G6QN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM glutamine amidotransferase class-I	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
CMS2_k127_3651974_3	1210884.HG799462_gene8482	5.496e-39	151.0	COG1846@1|root,COG1846@2|Bacteria,2IZUA@203682|Planctomycetes	203682|Planctomycetes	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
CMS2_k127_3651974_0	575540.Isop_0300	1.343e-49	183.0	COG2382@1|root,COG2382@2|Bacteria,2IYMZ@203682|Planctomycetes	203682|Planctomycetes	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase
CMS2_k127_3657180_2	1210884.HG799463_gene9879	2.126e-14	83.0	2AE0U@1|root,313TG@2|Bacteria,2IZTR@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3657180_3	933262.AXAM01000204_gene1274	1.52e-09	60.0	COG1895@1|root,COG1895@2|Bacteria,1Q7Y6@1224|Proteobacteria,433AB@68525|delta/epsilon subdivisions,2WYB2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_3657180_0	886293.Sinac_3038	5.666e-131	431.0	COG0044@1|root,COG0044@2|Bacteria,2IWS9@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
CMS2_k127_3657180_1	909663.KI867149_gene3341	6.927e-50	196.0	COG1409@1|root,COG1409@2|Bacteria,1R5W3@1224|Proteobacteria,42N0A@68525|delta/epsilon subdivisions,2WKFZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_3666754_4	420246.GTNG_2453	0.0001952	50.0	COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,4HKJ1@91061|Bacilli,1WEPQ@129337|Geobacillus	91061|Bacilli	L	SLBB domain	comEA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
CMS2_k127_3666754_0	1142394.PSMK_21970	2.903e-82	292.0	COG3693@1|root,COG3693@2|Bacteria,2IXI6@203682|Planctomycetes	203682|Planctomycetes	G	PFAM glycoside hydrolase, family 10	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_10
CMS2_k127_3666754_1	756272.Plabr_0049	2.422e-38	153.0	COG3023@1|root,COG3023@2|Bacteria,2J0EH@203682|Planctomycetes	203682|Planctomycetes	V	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
CMS2_k127_3666754_2	344747.PM8797T_20184	6.781e-31	126.0	COG2172@1|root,COG2172@2|Bacteria,2J0BZ@203682|Planctomycetes	203682|Planctomycetes	T	COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
CMS2_k127_3666754_3	756272.Plabr_3512	2.307e-22	100.0	COG1366@1|root,COG1366@2|Bacteria,2J02R@203682|Planctomycetes	203682|Planctomycetes	T	Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS2_k127_3699483_4	585394.RHOM_07860	2.601e-56	205.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia	186801|Clostridia	S	Abc transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
CMS2_k127_3699483_2	886293.Sinac_2714	4.066e-128	422.0	COG0673@1|root,COG0673@2|Bacteria,2IXFW@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_3699483_3	1123508.JH636440_gene2111	4.198e-104	359.0	COG0673@1|root,COG0673@2|Bacteria,2IXFW@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_3699483_1	1123508.JH636446_gene6207	3.702e-129	428.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,BAAT_C,Peptidase_S9
CMS2_k127_3699483_0	945713.IALB_2034	7.326e-172	556.0	COG0733@1|root,COG0733@2|Bacteria	2|Bacteria	S	neurotransmitter:sodium symporter activity	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
CMS2_k127_3699483_5	1499967.BAYZ01000059_gene4763	1.41e-33	134.0	COG1633@1|root,COG1633@2|Bacteria,2NQ7M@2323|unclassified Bacteria	2|Bacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_3699483_8	1449350.OCH239_13000	8.329e-15	88.0	COG2755@1|root,COG3087@1|root,COG3291@1|root,COG2755@2|Bacteria,COG3087@2|Bacteria,COG3291@2|Bacteria,1R8SK@1224|Proteobacteria,2UNN5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	G8	-	-	-	-	-	-	-	-	-	-	-	-	G8
CMS2_k127_3724987_3	234267.Acid_6615	9.045e-18	95.0	28KX8@1|root,2ZAD8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3724987_0	762968.HMPREF9441_01175	6.686e-103	344.0	COG0053@1|root,COG0053@2|Bacteria,4NEID@976|Bacteroidetes,2FNNF@200643|Bacteroidia	976|Bacteroidetes	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
CMS2_k127_3724987_2	1304885.AUEY01000118_gene2867	4.994e-55	203.0	COG0739@1|root,COG0739@2|Bacteria,1N19D@1224|Proteobacteria,42SMK@68525|delta/epsilon subdivisions,2WSC2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CMS2_k127_3724987_1	234267.Acid_2605	4.252e-70	247.0	COG2133@1|root,COG2133@2|Bacteria,3Y3FI@57723|Acidobacteria	57723|Acidobacteria	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_3734681_4	395019.Bmul_1838	6.145e-18	95.0	2E2AR@1|root,32XG5@2|Bacteria,1NJQ6@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Pathogenesis-related transcriptional factor and ERF	-	-	-	-	-	-	-	-	-	-	-	-	AP2,HNH_3
CMS2_k127_3734681_0	861299.J421_4459	0.0	1107.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
CMS2_k127_3734681_2	497964.CfE428DRAFT_4864	1.046e-61	222.0	COG1595@1|root,COG1595@2|Bacteria,46VE8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3734681_1	1123242.JH636435_gene2024	4.189e-160	543.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12,TPR_8,WD40
CMS2_k127_3734681_3	1123277.KB893217_gene4642	1.197e-41	157.0	COG3250@1|root,COG3250@2|Bacteria,4NFE8@976|Bacteroidetes,47MPU@768503|Cytophagia	976|Bacteroidetes	G	glycoside hydrolase family 2 sugar binding	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
CMS2_k127_3751498_5	1178825.ALIH01000005_gene160	1.636e-11	78.0	2DICN@1|root,32UAX@2|Bacteria,4NU78@976|Bacteroidetes,1I4Y5@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C
CMS2_k127_3751498_7	485917.Phep_2792	5.101e-08	66.0	COG3866@1|root,COG3866@2|Bacteria,4NJUK@976|Bacteroidetes	976|Bacteroidetes	G	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3751498_6	593907.Celgi_2571	3.763e-11	76.0	COG3209@1|root,COG3408@1|root,COG5492@1|root,COG3209@2|Bacteria,COG3408@2|Bacteria,COG5492@2|Bacteria,2GK37@201174|Actinobacteria	201174|Actinobacteria	N	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Big_4,Glyco_hydro_43,Laminin_G_3
CMS2_k127_3751498_1	889378.Spiaf_2383	1.208e-91	309.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	nodJ	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
CMS2_k127_3751498_0	1307761.L21SP2_2583	1.3e-106	354.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	nodI	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
CMS2_k127_3751498_2	518766.Rmar_1391	2.535e-65	234.0	COG0684@1|root,COG0684@2|Bacteria	2|Bacteria	H	ribonuclease inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
CMS2_k127_3751498_3	290317.Cpha266_1598	2.03e-56	204.0	COG3153@1|root,COG3153@2|Bacteria,1FE06@1090|Chlorobi	1090|Chlorobi	S	PFAM GCN5-related N-acetyltransferase	-	-	-	ko:K03824	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_7
CMS2_k127_3751498_4	1235790.C805_00844	1.882e-23	113.0	2E2AR@1|root,32XG5@2|Bacteria,1VC42@1239|Firmicutes,25DRJ@186801|Clostridia	186801|Clostridia	S	AP2 domain	-	-	-	-	-	-	-	-	-	-	-	-	AP2,HNH_3
CMS2_k127_375918_9	573413.Spirs_4232	1.099e-26	112.0	COG1215@1|root,COG1215@2|Bacteria,2J96W@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
CMS2_k127_375918_8	2340.JV46_27430	1.363e-31	124.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SWYS@1236|Gammaproteobacteria,1JB34@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Ribonuclease B OB domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD
CMS2_k127_375918_7	604354.TSIB_1126	3.533e-44	176.0	COG1906@1|root,arCOG04354@2157|Archaea,2XX2X@28890|Euryarchaeota,243P4@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF401)	-	-	-	ko:K09133	-	-	-	-	ko00000	-	-	-	DUF401
CMS2_k127_375918_10	861299.J421_0340	7.371e-12	75.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097,PA14
CMS2_k127_375918_1	706587.Desti_4248	1.251e-169	539.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PCA@68525|delta/epsilon subdivisions,2WM39@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS2_k127_375918_0	756272.Plabr_1302	2.339e-172	554.0	COG0156@1|root,COG0156@2|Bacteria,2IX0H@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_375918_4	1121335.Clst_1584	1.321e-61	230.0	COG0371@1|root,COG0371@2|Bacteria,1TR6W@1239|Firmicutes,25CDJ@186801|Clostridia,3WI4U@541000|Ruminococcaceae	186801|Clostridia	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
CMS2_k127_375918_5	382464.ABSI01000009_gene3921	7.116e-59	210.0	COG1502@1|root,COG1502@2|Bacteria,46X9U@74201|Verrucomicrobia,2IUGR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Phospholipase D Active site motif	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
CMS2_k127_375918_6	255470.cbdbA1366	5.311e-50	191.0	COG3359@1|root,COG3359@2|Bacteria,2G6TK@200795|Chloroflexi,34CWC@301297|Dehalococcoidia	301297|Dehalococcoidia	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
CMS2_k127_375918_3	645991.Sgly_1634	5.796e-84	289.0	COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,25KQ6@186801|Clostridia,264CY@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
CMS2_k127_375918_2	264732.Moth_1711	1.39e-136	459.0	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia,42FH2@68295|Thermoanaerobacterales	186801|Clostridia	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
CMS2_k127_376629_2	768066.HELO_3184	3.425e-59	211.0	COG1515@1|root,COG1515@2|Bacteria,1MWRN@1224|Proteobacteria,1RRYH@1236|Gammaproteobacteria,1XQTF@135619|Oceanospirillales	135619|Oceanospirillales	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
CMS2_k127_376629_0	237368.SCABRO_02223	1.313e-148	476.0	COG0714@1|root,COG0714@2|Bacteria,2IX23@203682|Planctomycetes	203682|Planctomycetes	S	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS2_k127_376629_1	237368.SCABRO_01880	1.281e-101	344.0	COG1721@1|root,COG1721@2|Bacteria,2IXT7@203682|Planctomycetes	203682|Planctomycetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS2_k127_376629_5	635013.TherJR_0179	5.431e-21	107.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,266W1@186807|Peptococcaceae	186801|Clostridia	M	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	prsA	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
CMS2_k127_376629_4	247490.KSU1_C0859	3.059e-34	148.0	28MJ6@1|root,2ZAVS@2|Bacteria,2J0MI@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_376629_3	314230.DSM3645_26899	9.714e-39	153.0	COG2304@1|root,COG2304@2|Bacteria,2IYWC@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
CMS2_k127_3771276_6	1122176.KB903534_gene2080	9.06e-14	76.0	COG2312@1|root,COG2312@2|Bacteria,4PP0J@976|Bacteroidetes	976|Bacteroidetes	E	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH,Fn3_assoc,LTD
CMS2_k127_3771276_1	756272.Plabr_1541	1.588e-220	694.0	COG0673@1|root,COG0673@2|Bacteria,2IYHX@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_3771276_0	234267.Acid_4012	1.309e-313	977.0	COG3525@1|root,COG3525@2|Bacteria	2|Bacteria	G	beta-N-acetylhexosaminidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3771276_2	234267.Acid_2976	5.811e-41	166.0	COG0667@1|root,COG0667@2|Bacteria,3Y3TE@57723|Acidobacteria	57723|Acidobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS2_k127_3771276_3	1121289.JHVL01000064_gene287	2.013e-36	149.0	COG2207@1|root,COG2207@2|Bacteria,1V3PR@1239|Firmicutes,24B7M@186801|Clostridia,36HSD@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator, arac family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS2_k127_3771276_4	251221.35211275	4.355e-28	122.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS2_k127_3771276_5	1121324.CLIT_2c01420	1.803e-27	115.0	COG0389@1|root,COG0389@2|Bacteria,1VEU0@1239|Firmicutes,24RTW@186801|Clostridia	186801|Clostridia	L	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Cdd1
CMS2_k127_3797624_1	1116472.MGMO_120c00330	4.973e-189	603.0	COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,1RMZS@1236|Gammaproteobacteria,1XEX4@135618|Methylococcales	135618|Methylococcales	S	Phage late control gene D protein (GPD)	-	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	Phage_GPD
CMS2_k127_3797624_0	857087.Metme_0858	0.0	1264.0	COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,1RMZH@1236|Gammaproteobacteria,1XEXC@135618|Methylococcales	135618|Methylococcales	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K11907	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	AAA,AAA_2,ClpB_D2-small
CMS2_k127_3797624_2	1172186.KB911475_gene4068	2.638e-79	283.0	COG2890@1|root,COG2890@2|Bacteria,2IBM1@201174|Actinobacteria,2388H@1762|Mycobacteriaceae	201174|Actinobacteria	J	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	MTS
CMS2_k127_3797624_3	497964.CfE428DRAFT_2863	5.453e-46	173.0	COG3515@1|root,COG3515@2|Bacteria,46WW4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ImpA, N-terminal, type VI secretion system	-	-	-	-	-	-	-	-	-	-	-	-	ImpA_N
CMS2_k127_3800125_0	589865.DaAHT2_0126	2.35e-195	619.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MIKK@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS2_k127_3800125_6	335543.Sfum_3266	4.51e-19	92.0	2FCYF@1|root,34516@2|Bacteria,1P1JS@1224|Proteobacteria,431WM@68525|delta/epsilon subdivisions,2WW7I@28221|Deltaproteobacteria,2MS73@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3800125_2	552811.Dehly_1484	3.695e-63	239.0	COG2197@1|root,COG2197@2|Bacteria,2GASM@200795|Chloroflexi,34D97@301297|Dehalococcoidia	301297|Dehalococcoidia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
CMS2_k127_3800125_7	269797.Mbar_A0726	2.716e-14	84.0	arCOG02527@1|root,arCOG02527@2157|Archaea,2XYVG@28890|Euryarchaeota	28890|Euryarchaeota	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
CMS2_k127_3800125_10	247490.KSU1_D0541	1.428e-06	55.0	2EDD9@1|root,3379K@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3568)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3568
CMS2_k127_3800125_11	243090.RB8750	4.945e-06	53.0	COG3506@1|root,COG3506@2|Bacteria	2|Bacteria	M	Protein of unknown function (DUF1349)	yjl217W	-	-	ko:K09702	-	-	-	-	ko00000	-	-	-	DUF1349
CMS2_k127_3800125_9	1210884.HG799463_gene9412	2.255e-08	59.0	COG4692@1|root,COG4692@2|Bacteria,2IX4M@203682|Planctomycetes	203682|Planctomycetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,VCBS
CMS2_k127_3800125_5	344747.PM8797T_24886	1.045e-34	146.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	1.11.1.7	ko:K19511	-	-	-	-	ko00000,ko01000	-	-	-	CAP,HemolysinCabind,Peptidase_M10_C,VCBS
CMS2_k127_3800125_13	398511.BpOF4_12315	0.0008631	50.0	COG2834@1|root,COG2834@2|Bacteria,1TR96@1239|Firmicutes,4HEBB@91061|Bacilli,1ZDX6@1386|Bacillus	91061|Bacilli	M	COG2834 Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092,LolA_like,MucB_RseB
CMS2_k127_3800125_8	1396141.BATP01000056_gene3251	5.574e-11	72.0	COG1595@1|root,COG1595@2|Bacteria,46VNT@74201|Verrucomicrobia,2IVV9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4
CMS2_k127_3800125_1	335283.Neut_0907	6.07e-80	283.0	COG0193@1|root,COG0770@1|root,COG0193@2|Bacteria,COG0770@2|Bacteria,1RHXY@1224|Proteobacteria	1224|Proteobacteria	M	Mur ligase middle domain protein	-	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_M,Pept_tRNA_hydro
CMS2_k127_3800125_12	1122182.KB903835_gene4577	0.0001854	49.0	COG1366@1|root,COG1366@2|Bacteria,2IHQG@201174|Actinobacteria,4DE05@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
CMS2_k127_3800125_3	411902.CLOBOL_05925	5.478e-60	216.0	COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia,21YHD@1506553|Lachnoclostridium	186801|Clostridia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
CMS2_k127_3800125_4	1049564.TevJSym_aa00830	1.365e-42	164.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,1S5B7@1236|Gammaproteobacteria,1J71P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
CMS2_k127_3813659_1	247490.KSU1_C1305	4e-323	999.0	COG0296@1|root,COG0296@2|Bacteria,2IXS1@203682|Planctomycetes	203682|Planctomycetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
CMS2_k127_3813659_0	247490.KSU1_C1304	0.0	1330.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2IXJN@203682|Planctomycetes	203682|Planctomycetes	G	alpha amylase catalytic	-	-	3.2.1.1,3.2.1.10,5.4.99.16	ko:K01182,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R01557,R01718,R01791,R02108,R02112,R06199,R11262	RC00028,RC00059,RC00077,RC00451,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459,Malt_amylase_C
CMS2_k127_3813659_2	247490.KSU1_C1303	2.036e-183	579.0	COG0366@1|root,COG0366@2|Bacteria,2IYAN@203682|Planctomycetes	203682|Planctomycetes	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
CMS2_k127_3826413_0	344747.PM8797T_30434	1.135e-121	407.0	COG1914@1|root,COG1914@2|Bacteria,2IYDP@203682|Planctomycetes	203682|Planctomycetes	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
CMS2_k127_3826413_1	344747.PM8797T_06165	8.371e-61	222.0	COG0284@1|root,COG0284@2|Bacteria,2IXSF@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
CMS2_k127_3826413_3	309807.SRU_0824	3.44e-42	168.0	COG0500@1|root,COG2226@2|Bacteria,4NEDR@976|Bacteroidetes,1FJ8B@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
CMS2_k127_3826413_2	237368.SCABRO_00429	1.83e-56	206.0	COG0771@1|root,COG0771@2|Bacteria,2IX53@203682|Planctomycetes	203682|Planctomycetes	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
CMS2_k127_384382_16	1124780.ANNU01000008_gene2683	4.632e-14	86.0	COG1649@1|root,COG3866@1|root,COG4733@1|root,COG1649@2|Bacteria,COG3866@2|Bacteria,COG4733@2|Bacteria,4P09P@976|Bacteroidetes,47MVU@768503|Cytophagia	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_384382_17	376686.Fjoh_2456	3.893e-12	80.0	COG3866@1|root,COG3866@2|Bacteria,4NJUK@976|Bacteroidetes,1IIIB@117743|Flavobacteriia,2NUS2@237|Flavobacterium	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_384382_13	1089548.KI783301_gene2047	4.569e-28	132.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.1.1.11	ko:K01051	ko00040,ko01100,map00040,map01100	M00081	R02362	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	CBM_6,Cadherin,DUF1929,HemolysinCabind,Malectin,Metallophos,PA14,Pur_ac_phosph_N
CMS2_k127_384382_9	497964.CfE428DRAFT_1249	2.858e-68	251.0	COG3866@1|root,COG3866@2|Bacteria,46SQX@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_384382_7	118173.KB235914_gene3829	2.242e-122	409.0	2DBP2@1|root,2ZA71@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_384382_14	504472.Slin_5123	3.379e-23	117.0	COG1520@1|root,COG1520@2|Bacteria,4NFA9@976|Bacteroidetes,47N9T@768503|Cytophagia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,PQQ,PQQ_2,PQQ_3
CMS2_k127_384382_6	118173.KB235914_gene3829	3.742e-132	436.0	2DBP2@1|root,2ZA71@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_384382_18	479432.Sros_2377	1.794e-06	61.0	COG1520@1|root,COG3386@1|root,COG1520@2|Bacteria,COG3386@2|Bacteria,2IFG3@201174|Actinobacteria,4EMZX@85012|Streptosporangiales	201174|Actinobacteria	G	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_384382_10	1068978.AMETH_6127	4.01e-50	206.0	2CB3G@1|root,33R2G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_384382_5	1303518.CCALI_00133	1.112e-135	474.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	galA	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_4_9,CBM_6,DUF1565
CMS2_k127_384382_12	1267535.KB906767_gene5000	2.328e-29	134.0	COG5512@1|root,COG5512@2|Bacteria	2|Bacteria	L	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	Collagen_bind_2,DUF4038,DUF5060,DUF721
CMS2_k127_384382_2	861299.J421_0373	1.621e-182	582.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	3.2.1.15	ko:K01184	ko00040,ko01100,map00040,map01100	M00081	R01982,R02360	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_28,Glyco_hydro_88,Pectate_lyase_3
CMS2_k127_384382_4	1396141.BATP01000030_gene3715	3.62e-136	475.0	COG2010@1|root,COG2312@1|root,COG5337@1|root,COG5563@1|root,COG2010@2|Bacteria,COG2312@2|Bacteria,COG5337@2|Bacteria,COG5563@2|Bacteria,46XD5@74201|Verrucomicrobia,2IVHX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Fn3_assoc,LTD
CMS2_k127_384382_15	511995.CFPG_531	9.707e-15	89.0	COG3630@1|root,COG3630@2|Bacteria,4NIHN@976|Bacteroidetes,2FMSV@200643|Bacteroidia	976|Bacteroidetes	C	Oxaloacetate decarboxylase, gamma chain	-	-	-	-	-	-	-	-	-	-	-	-	LTD,OAD_gamma
CMS2_k127_384382_3	694427.Palpr_0584	2.148e-161	536.0	COG3534@1|root,COG3534@2|Bacteria,4NGKW@976|Bacteroidetes,2FM0F@200643|Bacteroidia,22WCS@171551|Porphyromonadaceae	976|Bacteroidetes	G	PFAM alpha-L-arabinofuranosidase domain protein	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
CMS2_k127_384382_0	742727.HMPREF9447_03272	1.1e-301	942.0	COG1472@1|root,COG1472@2|Bacteria,4NEBU@976|Bacteroidetes,2FN0J@200643|Bacteroidia,4AQ3B@815|Bacteroidaceae	976|Bacteroidetes	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
CMS2_k127_384382_8	595460.RRSWK_02091	3.088e-88	306.0	COG1609@1|root,COG4977@1|root,COG1609@2|Bacteria,COG4977@2|Bacteria,2IXTX@203682|Planctomycetes	203682|Planctomycetes	K	Xylose operon regulatory protein	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18,Peripla_BP_3
CMS2_k127_384382_1	1329516.JPST01000024_gene2143	2.409e-191	608.0	COG2407@1|root,COG2407@2|Bacteria,1TQDX@1239|Firmicutes,4HCRT@91061|Bacilli	91061|Bacilli	G	isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_Isome,Fucose_iso_C
CMS2_k127_384382_11	1382359.JIAL01000001_gene1003	2.687e-35	137.0	COG0235@1|root,COG0235@2|Bacteria,3Y3W2@57723|Acidobacteria,2JHR0@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM Class II aldolase	-	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
CMS2_k127_3858820_1	880072.Desac_1384	1.266e-28	125.0	COG0286@1|root,COG0286@2|Bacteria,1NQAT@1224|Proteobacteria,430SQ@68525|delta/epsilon subdivisions	2|Bacteria	L	PFAM DNA methylase, adenine-specific	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,N6_Mtase,SNF2_N
CMS2_k127_3858820_0	583355.Caka_1736	1.894e-61	225.0	COG2312@1|root,COG2312@2|Bacteria,46TMX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH,LTD
CMS2_k127_3897245_9	690850.Desaf_2000	1.546e-45	180.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,42QZT@68525|delta/epsilon subdivisions,2WK41@28221|Deltaproteobacteria,2M9V3@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
CMS2_k127_3897245_0	1304888.ATWF01000001_gene2370	5.126e-289	925.0	COG0841@1|root,COG0841@2|Bacteria,2GESU@200930|Deferribacteres	200930|Deferribacteres	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS2_k127_3897245_4	118168.MC7420_6076	1.611e-111	365.0	COG0647@1|root,COG0647@2|Bacteria,1GCWQ@1117|Cyanobacteria,1HEEW@1150|Oscillatoriales	1117|Cyanobacteria	G	Belongs to the HAD-like hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
CMS2_k127_3897245_3	177437.HRM2_11540	1.601e-162	523.0	COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,42PC9@68525|delta/epsilon subdivisions,2WKA4@28221|Deltaproteobacteria,2MJ22@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Na dependent nucleoside transporter	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
CMS2_k127_3897245_10	247490.KSU1_D0525	4.746e-38	150.0	COG0662@1|root,COG0662@2|Bacteria,2J4Q9@203682|Planctomycetes	203682|Planctomycetes	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS2_k127_3897245_2	526222.Desal_1778	1.034e-186	597.0	COG0591@1|root,COG0591@2|Bacteria,1QZ58@1224|Proteobacteria,43CY5@68525|delta/epsilon subdivisions,2X869@28221|Deltaproteobacteria,2MHC8@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21.2	-	-	SSF
CMS2_k127_3897245_11	368407.Memar_2196	3.279e-29	125.0	arCOG06881@1|root,arCOG06881@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3897245_7	314230.DSM3645_24020	5.038e-66	240.0	COG1459@1|root,COG1459@2|Bacteria,2IYHA@203682|Planctomycetes	203682|Planctomycetes	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
CMS2_k127_3897245_1	521674.Plim_0426	6.017e-200	641.0	COG2804@1|root,COG2804@2|Bacteria,2IX4I@203682|Planctomycetes	203682|Planctomycetes	NU	COG2804 Type II secretory pathway ATPase PulE Tfp pilus assembly pathway ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
CMS2_k127_3897245_13	1150474.JQJI01000002_gene1165	3.87e-08	59.0	COG1366@1|root,COG1366@2|Bacteria,2GDAN@200918|Thermotogae	200918|Thermotogae	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS2_k127_3897245_8	1142394.PSMK_14390	6.669e-58	223.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2J518@203682|Planctomycetes	203682|Planctomycetes	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,HD_5
CMS2_k127_3897245_12	521674.Plim_0428	2.465e-24	107.0	COG0745@1|root,COG0745@2|Bacteria,2J15S@203682|Planctomycetes	203682|Planctomycetes	T	PFAM response regulator receiver	-	-	-	ko:K11329	ko02020,map02020	M00467	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
CMS2_k127_3897245_6	314230.DSM3645_24040	6.172e-69	252.0	COG5002@1|root,COG5002@2|Bacteria,2IZ3S@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS2_k127_3897245_5	1142394.PSMK_14360	1.48e-83	297.0	COG4796@1|root,COG4796@2|Bacteria,2IY1C@203682|Planctomycetes	203682|Planctomycetes	U	Belongs to the GSP D family	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	STN,Secretin
CMS2_k127_3902272_3	1396141.BATP01000057_gene3053	6.627e-108	377.0	COG2312@1|root,COG3209@1|root,COG2312@2|Bacteria,COG3209@2|Bacteria,46XD5@74201|Verrucomicrobia,2IVHX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Fn3_assoc,LTD
CMS2_k127_3902272_13	1283300.ATXB01000001_gene378	6.867e-24	106.0	2DXHE@1|root,3451P@2|Bacteria,1P3C9@1224|Proteobacteria,1SRS6@1236|Gammaproteobacteria,1XGRM@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3902272_4	572544.Ilyop_1708	7.036e-100	347.0	COG1757@1|root,COG1757@2|Bacteria,379JM@32066|Fusobacteria	32066|Fusobacteria	C	Na+/H+ antiporter family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
CMS2_k127_3902272_14	1267533.KB906735_gene4811	4.97e-19	102.0	COG1267@1|root,COG1267@2|Bacteria,3Y4T1@57723|Acidobacteria,2JJH6@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM Phosphatidylglycerophosphatase A	-	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
CMS2_k127_3902272_10	886293.Sinac_3598	9.448e-55	201.0	2CB5F@1|root,2ZCDM@2|Bacteria,2IXTM@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3902272_17	1303518.CCALI_02046	1.875e-11	76.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02679	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_3902272_1	2325.TKV_c24210	5.227e-142	467.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,42FKX@68295|Thermoanaerobacterales	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
CMS2_k127_3902272_7	314230.DSM3645_07730	1.557e-80	278.0	COG0020@1|root,COG0020@2|Bacteria,2IX6Z@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
CMS2_k127_3902272_11	1210884.HG799469_gene14232	5.11e-34	142.0	COG4589@1|root,COG4589@2|Bacteria,2J032@203682|Planctomycetes	203682|Planctomycetes	S	Phosphatidate cytidylyltransferase	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
CMS2_k127_3902272_6	530564.Psta_2532	3.595e-88	304.0	COG1702@1|root,COG1702@2|Bacteria,2IXBB@203682|Planctomycetes	203682|Planctomycetes	T	Phosphate starvation-inducible protein PhoH	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
CMS2_k127_3902272_5	1142394.PSMK_17540	1.896e-94	329.0	COG1480@1|root,COG1480@2|Bacteria,2IYP7@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
CMS2_k127_3902272_16	1089550.ATTH01000001_gene1110	1.428e-13	77.0	COG0319@1|root,COG0319@2|Bacteria,4NS93@976|Bacteroidetes,1FJIK@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	-	-	-	-	-	-	-	-	-	UPF0054
CMS2_k127_3902272_8	756272.Plabr_1325	1.716e-65	241.0	COG1253@1|root,COG1253@2|Bacteria,2IZAU@203682|Planctomycetes	203682|Planctomycetes	S	COG1253 Hemolysins and related	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
CMS2_k127_3902272_12	344747.PM8797T_14219	2.139e-32	137.0	COG1381@1|root,COG1381@2|Bacteria,2IZU9@203682|Planctomycetes	203682|Planctomycetes	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
CMS2_k127_3902272_15	1268635.Loa_01868	1.544e-15	87.0	2D6MI@1|root,30AQT@2|Bacteria,1P8HC@1224|Proteobacteria,1T7XG@1236|Gammaproteobacteria,1JFZQ@118969|Legionellales	118969|Legionellales	S	PAP2 superfamily C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_C
CMS2_k127_3902272_9	1150474.JQJI01000002_gene1124	2.781e-63	230.0	COG4671@1|root,COG4671@2|Bacteria	2|Bacteria	I	Glycosyl Transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,Glyco_trans_1_3
CMS2_k127_3902272_2	1232410.KI421415_gene3116	3.239e-115	381.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2WJ2Q@28221|Deltaproteobacteria,43S6A@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Holliday junction DNA helicase ruvB C-terminus	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
CMS2_k127_3913426_0	459349.CLOAM1364	4.461e-223	728.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2NNKA@2323|unclassified Bacteria	2|Bacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
CMS2_k127_3934801_5	1121481.AUAS01000002_gene3442	3.296e-55	203.0	COG2866@1|root,COG2866@2|Bacteria,4NJB9@976|Bacteroidetes,47SV8@768503|Cytophagia	976|Bacteroidetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS2_k127_3934801_6	1382306.JNIM01000001_gene1984	2.135e-43	168.0	COG0637@1|root,COG0637@2|Bacteria,2G6ZZ@200795|Chloroflexi	200795|Chloroflexi	O	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2,Peptidase_M22
CMS2_k127_3934801_3	1121405.dsmv_1706	7.764e-100	335.0	COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,42MCJ@68525|delta/epsilon subdivisions,2WKQ4@28221|Deltaproteobacteria,2MIE6@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS2_k127_3934801_10	1307759.JOMJ01000003_gene677	4.791e-07	62.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2M88F@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS2_k127_3934801_7	118173.KB235914_gene1888	2.716e-38	154.0	COG1216@1|root,COG1216@2|Bacteria,1G4VQ@1117|Cyanobacteria,1HD9F@1150|Oscillatoriales	1117|Cyanobacteria	S	Glycosyltransferase like family 2	-	-	-	ko:K12992	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01005	-	GT2	-	Glycos_transf_2
CMS2_k127_3934801_0	1237149.C900_02409	8.414e-154	497.0	COG4091@1|root,COG4091@2|Bacteria,4NKWV@976|Bacteroidetes,47REG@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_3,Shikimate_DH
CMS2_k127_3934801_8	1122604.JONR01000013_gene3220	1.434e-23	111.0	2BP06@1|root,32HQG@2|Bacteria,1RK5Z@1224|Proteobacteria,1SJ51@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3934801_2	886293.Sinac_1335	8.136e-108	357.0	COG1413@1|root,COG1413@2|Bacteria,2IYWU@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_3934801_11	1331060.RLDS_12525	7.96e-05	53.0	COG1595@1|root,COG1595@2|Bacteria,1N6SV@1224|Proteobacteria,2UDT4@28211|Alphaproteobacteria,2KAYJ@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_3934801_1	886293.Sinac_4629	1.641e-137	451.0	COG0673@1|root,COG0673@2|Bacteria,2IWX9@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_3934801_4	1122605.KB893625_gene1710	1.207e-63	243.0	COG1572@1|root,COG1572@2|Bacteria,4NT56@976|Bacteroidetes,1IZ9N@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4091)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4091
CMS2_k127_3948051_0	1523503.JPMY01000023_gene1029	3.423e-18	91.0	COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1SASQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_3956518_1	1150474.JQJI01000008_gene1360	6.06e-77	269.0	COG1899@1|root,COG1899@2|Bacteria,2GDSY@200918|Thermotogae	200918|Thermotogae	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3956518_0	929562.Emtol_1243	1.484e-194	616.0	COG2942@1|root,COG2942@2|Bacteria,4NHTQ@976|Bacteroidetes,47KVQ@768503|Cytophagia	976|Bacteroidetes	G	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)	-	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
CMS2_k127_3956518_2	886293.Sinac_5728	5.929e-47	179.0	COG2264@1|root,COG2264@2|Bacteria,2J3H0@203682|Planctomycetes	203682|Planctomycetes	J	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
CMS2_k127_3956518_3	1116375.VEJY3_05310	8.451e-13	77.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RSP9@1236|Gammaproteobacteria,1XXZ7@135623|Vibrionales	135623|Vibrionales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS2_k127_3966597_2	1380390.JIAT01000011_gene2883	7.631e-17	94.0	COG0028@1|root,COG0515@1|root,COG1409@1|root,COG1749@1|root,COG2374@1|root,COG3291@1|root,COG3509@1|root,COG4733@1|root,COG0028@2|Bacteria,COG0515@2|Bacteria,COG1409@2|Bacteria,COG1749@2|Bacteria,COG2374@2|Bacteria,COG3291@2|Bacteria,COG3509@2|Bacteria,COG4733@2|Bacteria,2I2X3@201174|Actinobacteria,4CSIX@84995|Rubrobacteria	84995|Rubrobacteria	N	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,fn3
CMS2_k127_3966597_0	1123242.JH636436_gene459	1.253e-42	174.0	COG4886@1|root,COG4886@2|Bacteria,2J0H6@203682|Planctomycetes	203682|Planctomycetes	K	Leucine-rich repeats, outliers	-	-	-	-	-	-	-	-	-	-	-	-	LRR_6,LRR_8
CMS2_k127_3966597_1	483219.LILAB_07995	2.883e-17	96.0	COG4932@1|root,COG4932@2|Bacteria,1PEGG@1224|Proteobacteria,43854@68525|delta/epsilon subdivisions,2X3F3@28221|Deltaproteobacteria,2YVTB@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS2_k127_3976986_4	861299.J421_0867	2.252e-63	233.0	COG0515@1|root,COG0515@2|Bacteria	861299.J421_0867|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
CMS2_k127_3976986_10	469381.Dpep_1040	6.505e-25	111.0	COG3328@1|root,COG3328@2|Bacteria,3TCEK@508458|Synergistetes	508458|Synergistetes	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
CMS2_k127_3976986_8	1454004.AW11_00407	4.403e-27	116.0	COG0012@1|root,COG0012@2|Bacteria,1Q097@1224|Proteobacteria,2W504@28216|Betaproteobacteria	28216|Betaproteobacteria	J	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3976986_3	794903.OPIT5_11255	6.046e-91	317.0	COG0012@1|root,COG0012@2|Bacteria,46UY8@74201|Verrucomicrobia	74201|Verrucomicrobia	J	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3976986_9	1274524.BSONL12_04374	1.61e-25	117.0	2E2AR@1|root,32XG5@2|Bacteria,1VHHN@1239|Firmicutes	1239|Firmicutes	S	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	AP2,HNH_3
CMS2_k127_3976986_7	237368.SCABRO_03846	2.1e-31	137.0	COG3009@1|root,COG3009@2|Bacteria	2|Bacteria	Q	Protein conserved in bacteria	-	-	-	ko:K18480	-	M00669	-	-	ko00000,ko00002,ko02000	3.A.1.27.1	-	-	ABC_trans_aux
CMS2_k127_3976986_5	237368.SCABRO_03847	2.717e-44	176.0	COG1463@1|root,COG1463@2|Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component	iamC	-	-	ko:K02067,ko:K06192	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
CMS2_k127_3976986_2	1121456.ATVA01000011_gene1655	5.09e-97	323.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,2M8FK@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM ABC transporter related	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
CMS2_k127_3976986_1	237368.SCABRO_03849	9.442e-101	340.0	COG0767@1|root,COG0767@2|Bacteria,2IX01@203682|Planctomycetes	203682|Planctomycetes	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
CMS2_k127_3976986_0	471854.Dfer_5258	7.425e-144	466.0	COG0673@1|root,COG0673@2|Bacteria,4NN43@976|Bacteroidetes,47UBC@768503|Cytophagia	976|Bacteroidetes	Q	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_3976986_6	880071.Fleli_1852	2.046e-36	145.0	COG1595@1|root,COG1595@2|Bacteria,4NETF@976|Bacteroidetes,47QDK@768503|Cytophagia	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_3995577_13	595460.RRSWK_04952	3.966e-06	59.0	COG0823@1|root,COG2373@1|root,COG0823@2|Bacteria,COG2373@2|Bacteria,2J38T@203682|Planctomycetes	203682|Planctomycetes	U	Best DB hits BLAST	-	-	-	-	-	-	-	-	-	-	-	-	DUF1581,DUF1583,PD40
CMS2_k127_3995577_10	1182590.BN5_02144	1.502e-12	74.0	COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1SASQ@1236|Gammaproteobacteria,1YCT8@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_3995577_0	756272.Plabr_2780	0.0	1159.0	COG0542@1|root,COG0542@2|Bacteria,2IXHI@203682|Planctomycetes	203682|Planctomycetes	O	with chaperone activity ATP-binding	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
CMS2_k127_3995577_2	479434.Sthe_1363	1.429e-65	239.0	COG0299@1|root,COG0299@2|Bacteria,2G6ZJ@200795|Chloroflexi,27Y8N@189775|Thermomicrobia	189775|Thermomicrobia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
CMS2_k127_3995577_8	1382359.JIAL01000001_gene2755	4.496e-29	130.0	COG0328@1|root,COG0328@2|Bacteria,3Y7XW@57723|Acidobacteria,2JMYG@204432|Acidobacteriia	204432|Acidobacteriia	L	Reverse transcriptase-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_3
CMS2_k127_3995577_11	404380.Gbem_0479	1.125e-10	71.0	COG1579@1|root,COG1579@2|Bacteria,1R7GT@1224|Proteobacteria,42P3S@68525|delta/epsilon subdivisions,2WKVG@28221|Deltaproteobacteria,43UXQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
CMS2_k127_3995577_1	1121090.KB894697_gene2004	5.131e-67	244.0	COG0624@1|root,COG0624@2|Bacteria,1TPMJ@1239|Firmicutes,4HB39@91061|Bacilli,1ZEB6@1386|Bacillus	91061|Bacilli	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS2_k127_3995577_3	485916.Dtox_0855	2.98e-62	224.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	MA20_02340	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
CMS2_k127_3995577_6	368407.Memar_1122	2.31e-33	138.0	COG0454@1|root,arCOG00844@2157|Archaea,2Y70V@28890|Euryarchaeota,2NB0F@224756|Methanomicrobia	224756|Methanomicrobia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
CMS2_k127_3995577_7	138119.DSY3078	7.729e-33	134.0	2ERMK@1|root,33J72@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
CMS2_k127_3995577_9	243090.RB11418	2.649e-16	83.0	COG3837@1|root,COG3837@2|Bacteria	2|Bacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_19,HTH_3,HTH_31
CMS2_k127_3995577_5	562970.Btus_2079	6.298e-46	171.0	COG0454@1|root,COG0456@2|Bacteria,1V562@1239|Firmicutes,4HMAE@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
CMS2_k127_3995577_4	484770.UFO1_1728	1.366e-53	192.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,4H39N@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	-	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
CMS2_k127_3997427_5	589924.Ferp_0635	9.478e-09	66.0	arCOG10887@1|root,arCOG10887@2157|Archaea	589924.Ferp_0635|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_3997427_4	192952.MM_1119	9.261e-10	72.0	arCOG03500@1|root,arCOG03500@2157|Archaea	2157|Archaea	P	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	Disaggr_assoc
CMS2_k127_3997427_2	457570.Nther_0354	2.365e-14	87.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Beta_helix
CMS2_k127_3997427_1	1158604.I591_00617	5.503e-23	115.0	COG4886@1|root,COG4886@2|Bacteria,1V3UH@1239|Firmicutes,4I2HR@91061|Bacilli,4B3XD@81852|Enterococcaceae	91061|Bacilli	S	Leucine Rich repeats (2 copies)	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	LRR_4,LRR_adjacent
CMS2_k127_3997427_3	1123320.KB889698_gene9323	6.791e-13	81.0	COG2133@1|root,COG3055@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3055@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Calx-beta,GSDH,Laminin_G_3,Malectin,PKD
CMS2_k127_3997427_0	391596.PBAL39_01682	3.774e-30	136.0	COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1IPCG@117747|Sphingobacteriia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
CMS2_k127_4035445_24	290397.Adeh_0409	2.373e-14	82.0	COG3005@1|root,COG3005@2|Bacteria,1NT6I@1224|Proteobacteria,42YAG@68525|delta/epsilon subdivisions,2WTY3@28221|Deltaproteobacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS2_k127_4035445_13	563040.Saut_1067	8.113e-42	175.0	COG2199@1|root,COG5002@1|root,COG3706@2|Bacteria,COG5002@2|Bacteria,1R7HC@1224|Proteobacteria,42YDE@68525|delta/epsilon subdivisions,2YR8G@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	Diguanylate cyclase with PAS PAC sensor	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS
CMS2_k127_4035445_27	290397.Adeh_3728	1.493e-10	74.0	COG3829@1|root,COG3852@1|root,COG3829@2|Bacteria,COG3852@2|Bacteria,1QW3X@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE
CMS2_k127_4035445_15	1121441.AUCX01000004_gene3024	9.531e-36	142.0	COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,42R2R@68525|delta/epsilon subdivisions,2WMSJ@28221|Deltaproteobacteria,2MBJW@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	transcriptional regulator, AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_AsnC-type
CMS2_k127_4035445_28	886293.Sinac_0221	5.477e-09	67.0	COG0755@1|root,COG0755@2|Bacteria,2IZXD@203682|Planctomycetes	203682|Planctomycetes	O	PFAM Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
CMS2_k127_4035445_6	247490.KSU1_C1592	1.093e-82	290.0	COG0373@1|root,COG0373@2|Bacteria,2IXE9@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
CMS2_k127_4035445_5	247490.KSU1_C1279	3.312e-101	347.0	COG0535@1|root,COG0535@2|Bacteria,2IZE3@203682|Planctomycetes	203682|Planctomycetes	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS2_k127_4035445_1	237368.SCABRO_00988	1.653e-141	460.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	nirJ	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS2_k127_4035445_10	880073.Calab_3405	1.739e-48	196.0	COG4191@1|root,COG4191@2|Bacteria,2NPGF@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_9,Response_reg
CMS2_k127_4035445_2	880073.Calab_3404	2.698e-137	450.0	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02667,ko:K07714	ko02020,map02020	M00500,M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_4035445_22	857293.CAAU_2560	4.617e-16	83.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,36J5P@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	iscR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS2_k127_4035445_14	349161.Dred_2158	4.321e-37	144.0	COG1522@1|root,COG1522@2|Bacteria,1V6TK@1239|Firmicutes,24KE6@186801|Clostridia,2627S@186807|Peptococcaceae	186801|Clostridia	K	SMART Transcription regulator, AsnC-type	nirD	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
CMS2_k127_4035445_12	1121918.ARWE01000001_gene1777	3.738e-46	180.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,42M1B@68525|delta/epsilon subdivisions,2WK2M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K02523,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
CMS2_k127_4035445_19	909663.KI867150_gene2880	1.906e-25	111.0	COG0745@1|root,COG0745@2|Bacteria,1PGXZ@1224|Proteobacteria,437JJ@68525|delta/epsilon subdivisions,2X2TK@28221|Deltaproteobacteria,2MSE0@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_4035445_9	1125863.JAFN01000001_gene1695	6.587e-58	219.0	COG3005@1|root,COG3005@2|Bacteria,1RJ3G@1224|Proteobacteria,42ST3@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII,Cytochrom_NNT,Cytochrome_C7
CMS2_k127_4035445_3	1125863.JAFN01000001_gene977	1.632e-128	425.0	COG3005@1|root,COG3005@2|Bacteria,1R8V7@1224|Proteobacteria,42YES@68525|delta/epsilon subdivisions,2WU80@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM cytochrome C family protein	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS2_k127_4035445_23	1125863.JAFN01000001_gene976	5.292e-16	90.0	COG0457@1|root,COG0457@2|Bacteria	1125863.JAFN01000001_gene976|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4035445_17	880073.Calab_1267	1.12e-32	134.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552,Paired_CXXCH_1
CMS2_k127_4035445_8	1167006.UWK_00562	2.526e-59	223.0	COG3391@1|root,COG3391@2|Bacteria,1PE62@1224|Proteobacteria,43768@68525|delta/epsilon subdivisions,2X25C@28221|Deltaproteobacteria,2MP74@213118|Desulfobacterales	28221|Deltaproteobacteria	G	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4035445_20	243231.GSU3223	7.776e-23	112.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS2_k127_4035445_7	338969.Rfer_0258	2.562e-68	245.0	COG3391@1|root,COG3391@2|Bacteria,1MYI5@1224|Proteobacteria,2WEWP@28216|Betaproteobacteria	28216|Betaproteobacteria	G	6-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	NHL
CMS2_k127_4035445_0	880073.Calab_1263	2.505e-169	548.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS2_k127_4035445_21	1499967.BAYZ01000040_gene2246	4.006e-19	91.0	COG2332@1|root,COG2332@2|Bacteria,2NQ2A@2323|unclassified Bacteria	2|Bacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
CMS2_k127_4035445_4	562970.Btus_2649	2.496e-114	392.0	COG1138@1|root,COG1138@2|Bacteria,1UH6S@1239|Firmicutes,4HF5S@91061|Bacilli,27992@186823|Alicyclobacillaceae	91061|Bacilli	O	Cytochrome c-type biogenesis protein CcmF C-terminal	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
CMS2_k127_4035445_26	1382306.JNIM01000001_gene131	1.179e-12	79.0	COG2010@1|root,COG2010@2|Bacteria,2G741@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Cytochrome_CBB3
CMS2_k127_4035445_11	1125863.JAFN01000001_gene3012	3.61e-48	183.0	COG1131@1|root,COG1131@2|Bacteria,1RGM1@1224|Proteobacteria,43ADE@68525|delta/epsilon subdivisions,2X5TA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
CMS2_k127_4035445_18	926569.ANT_19400	8.94e-26	116.0	COG2386@1|root,COG2386@2|Bacteria,2G6TN@200795|Chloroflexi	200795|Chloroflexi	O	PFAM cytochrome c-type biogenesis protein CcmB	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
CMS2_k127_4035445_16	644968.DFW101_0560	1.668e-34	142.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,42RU4@68525|delta/epsilon subdivisions,2WNN7@28221|Deltaproteobacteria,2M9X3@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM Cytochrome c assembly protein	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
CMS2_k127_4035445_25	584708.Apau_0454	3.47e-14	75.0	COG0482@1|root,COG0482@2|Bacteria,3TAWU@508458|Synergistetes	508458|Synergistetes	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
CMS2_k127_4051579_1	886293.Sinac_5628	7.82e-121	407.0	COG4409@1|root,COG4692@1|root,COG4409@2|Bacteria,COG4692@2|Bacteria,2IX68@203682|Planctomycetes	203682|Planctomycetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
CMS2_k127_4051579_2	1304874.JAFY01000007_gene1685	2.843e-89	305.0	COG1180@1|root,COG1180@2|Bacteria,3T9PA@508458|Synergistetes	508458|Synergistetes	C	TIGRFAM glycyl-radical enzyme activating protein family	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
CMS2_k127_4051579_0	1121422.AUMW01000009_gene3340	0.0	1209.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,2618A@186807|Peptococcaceae	186801|Clostridia	C	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
CMS2_k127_4051579_3	771875.Ferpe_0712	5.232e-28	125.0	COG1520@1|root,COG1520@2|Bacteria,2GCVR@200918|Thermotogae	200918|Thermotogae	F	PFAM PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
CMS2_k127_406951_0	215803.DB30_6550	2.588e-165	540.0	COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,42N0P@68525|delta/epsilon subdivisions,2WJCQ@28221|Deltaproteobacteria,2YU1P@29|Myxococcales	28221|Deltaproteobacteria	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
CMS2_k127_406951_3	338963.Pcar_3027	1.679e-46	175.0	COG2095@1|root,COG2095@2|Bacteria	2|Bacteria	U	MarC family integral membrane protein	yhgN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
CMS2_k127_406951_7	483219.LILAB_20005	3.984e-07	57.0	COG1716@1|root,COG1716@2|Bacteria,1PCHK@1224|Proteobacteria,438FP@68525|delta/epsilon subdivisions,2X3QN@28221|Deltaproteobacteria,2YWV4@29|Myxococcales	28221|Deltaproteobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
CMS2_k127_406951_5	886293.Sinac_6587	3.163e-12	79.0	COG1595@1|root,COG1595@2|Bacteria,2IZMT@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_406951_1	1158294.JOMI01000004_gene3543	1.187e-95	328.0	COG3386@1|root,COG3386@2|Bacteria,4NF4A@976|Bacteroidetes,2FSDK@200643|Bacteroidia	976|Bacteroidetes	G	SMP-30 Gluconolaconase LRE-like	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pectate_lyase_3,SGL
CMS2_k127_406951_4	512565.AMIS_51980	2.247e-21	109.0	COG1649@1|root,COG1649@2|Bacteria,2GKNP@201174|Actinobacteria,4DATR@85008|Micromonosporales	201174|Actinobacteria	S	Glycosyl hydrolase-like 10	-	-	-	-	-	-	-	-	-	-	-	-	GHL10
CMS2_k127_406951_6	1123242.JH636436_gene177	4.954e-10	70.0	COG2165@1|root,COG2165@2|Bacteria,2IYB7@203682|Planctomycetes	203682|Planctomycetes	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_406951_2	880073.Calab_3098	1.773e-69	244.0	COG2755@1|root,COG2755@2|Bacteria,2NQ5Y@2323|unclassified Bacteria	2|Bacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	3.2.1.14,3.2.1.4	ko:K01179,ko:K01183	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R01206,R02334,R06200,R11307,R11308	RC00467	ko00000,ko00001,ko01000	-	GH18,GH5,GH9	-	Lipase_GDSL_2
CMS2_k127_406951_8	880073.Calab_0921	2.187e-06	55.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,FctA,Peptidase_M43
CMS2_k127_4096291_3	247490.KSU1_C0977	4.959e-10	73.0	COG0760@1|root,COG0760@2|Bacteria,2J38Q@203682|Planctomycetes	203682|Planctomycetes	O	SurA N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4096291_0	479434.Sthe_1801	3.496e-149	483.0	COG0001@1|root,COG0001@2|Bacteria,2G67D@200795|Chloroflexi,27Y34@189775|Thermomicrobia	189775|Thermomicrobia	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS2_k127_4096291_2	1313421.JHBV01000014_gene3924	9.105e-15	83.0	COG2374@1|root,COG2374@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Big_4,Big_5,DUF3494,Exo_endo_phos,LTD,SLH
CMS2_k127_4102771_0	706587.Desti_5381	0.0	1146.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42MI4@68525|delta/epsilon subdivisions,2WKB9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K08357	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10150	RC03109	ko00000,ko00001,ko02000	5.A.3.10	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS2_k127_4102771_4	1415778.JQMM01000001_gene1827	5.272e-56	212.0	COG2067@1|root,COG2067@2|Bacteria,1R12P@1224|Proteobacteria	1224|Proteobacteria	I	Putative porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_5
CMS2_k127_4102771_2	518766.Rmar_0034	1.075e-61	229.0	COG0303@1|root,COG0303@2|Bacteria,4NDYD@976|Bacteroidetes	976|Bacteroidetes	H	Molybdenum cofactor synthesis domain	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
CMS2_k127_4102771_3	443143.GM18_1211	1.833e-58	220.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,42NBV@68525|delta/epsilon subdivisions,2WK0F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
CMS2_k127_4102771_1	1408437.JNJN01000019_gene9	1.383e-90	308.0	COG0521@1|root,COG2258@1|root,COG0521@2|Bacteria,COG2258@2|Bacteria,1V3XM@1239|Firmicutes,24HG2@186801|Clostridia,25WK8@186806|Eubacteriaceae	186801|Clostridia	H	Probable molybdopterin binding domain	mog	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
CMS2_k127_4102771_6	653733.Selin_0095	5.016e-21	100.0	COG1763@1|root,COG1763@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	mobB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.10.1.1,2.7.7.77	ko:K02379,ko:K03750,ko:K03752,ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R09735,R11581	RC03462	ko00000,ko00001,ko01000	-	-	iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805	MoCF_biosynth,MobB,MoeA_C,MoeA_N,NTP_transf_3
CMS2_k127_4110210_8	530564.Psta_1682	5.924e-09	63.0	COG2314@1|root,COG2314@2|Bacteria,2J0G7@203682|Planctomycetes	203682|Planctomycetes	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4110210_2	575540.Isop_2850	4.69e-66	233.0	COG0571@1|root,COG0571@2|Bacteria,2IYW1@203682|Planctomycetes	203682|Planctomycetes	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
CMS2_k127_4110210_9	392499.Swit_1492	2.126e-06	54.0	COG1366@1|root,COG1366@2|Bacteria,1N7D9@1224|Proteobacteria,2UH20@28211|Alphaproteobacteria,2KB57@204457|Sphingomonadales	204457|Sphingomonadales	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
CMS2_k127_4110210_0	1123508.JH636440_gene2179	2.233e-174	561.0	COG0606@1|root,COG0606@2|Bacteria,2IWTT@203682|Planctomycetes	203682|Planctomycetes	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
CMS2_k127_4110210_3	1033732.CAHI01000030_gene891	8.821e-52	191.0	COG1957@1|root,COG2191@1|root,COG1957@2|Bacteria,COG2191@2|Bacteria,4PITJ@976|Bacteroidetes,2FXEM@200643|Bacteroidia	976|Bacteroidetes	CF	FmdE, Molybdenum formylmethanofuran dehydrogenase operon	-	-	-	ko:K01250	-	-	-	-	ko00000,ko01000	-	-	-	FmdE,IU_nuc_hydro
CMS2_k127_4110210_11	1142394.PSMK_14670	0.0001021	52.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_4110210_4	525897.Dbac_3231	1.463e-31	128.0	COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,42SID@68525|delta/epsilon subdivisions,2WQ86@28221|Deltaproteobacteria,2MBEU@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Transcriptional regulator	nikR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
CMS2_k127_4110210_1	909663.KI867150_gene2054	4.814e-89	299.0	COG2836@1|root,COG2836@2|Bacteria,1QVGG@1224|Proteobacteria,432GS@68525|delta/epsilon subdivisions,2WXZW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
CMS2_k127_4110210_10	1121438.JNJA01000003_gene3205	1.226e-05	51.0	COG1917@1|root,COG1917@2|Bacteria,1N2JS@1224|Proteobacteria,42TR3@68525|delta/epsilon subdivisions,2WQ4M@28221|Deltaproteobacteria,2MBZC@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS2_k127_4110210_7	314230.DSM3645_15950	1.282e-17	90.0	2B8BF@1|root,321K5@2|Bacteria,2IZTE@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function DUF2617	-	-	-	-	-	-	-	-	-	-	-	-	DUF2617
CMS2_k127_4110210_6	530564.Psta_2461	1.064e-23	111.0	COG1266@1|root,COG1266@2|Bacteria,2J06D@203682|Planctomycetes	203682|Planctomycetes	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
CMS2_k127_4112885_1	472759.Nhal_3091	6.206e-155	504.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1WXBI@135613|Chromatiales	135613|Chromatiales	S	oligopeptide transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
CMS2_k127_4112885_0	880073.Calab_2784	2.777e-219	698.0	COG1164@1|root,COG1164@2|Bacteria,2NQ8K@2323|unclassified Bacteria	2|Bacteria	E	Oligoendopeptidase f	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2,Peptidase_M3
CMS2_k127_4112885_2	452637.Oter_1524	5.241e-130	426.0	COG3104@1|root,COG3104@2|Bacteria	2|Bacteria	E	oligopeptide transport	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
CMS2_k127_4128912_5	278957.ABEA03000095_gene4625	2.122e-15	82.0	COG1595@1|root,COG1595@2|Bacteria,46TFV@74201|Verrucomicrobia,3K7DZ@414999|Opitutae	414999|Opitutae	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_4128912_6	1123242.JH636435_gene2923	1.231e-14	82.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	fecI	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_4128912_1	1167006.UWK_02172	8.184e-150	492.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42ZBZ@68525|delta/epsilon subdivisions,2X5D0@28221|Deltaproteobacteria,2MMNI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	MacB_PCD
CMS2_k127_4128912_0	1232437.KL662020_gene700	5.692e-153	505.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42PAC@68525|delta/epsilon subdivisions,2WKAD@28221|Deltaproteobacteria,2MMGU@213118|Desulfobacterales	28221|Deltaproteobacteria	M	HlyD membrane-fusion protein of T1SS	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS2_k127_4128912_8	886293.Sinac_4705	7.884e-05	55.0	COG2834@1|root,COG2834@2|Bacteria,2J4MG@203682|Planctomycetes	203682|Planctomycetes	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4128912_4	1294143.H681_15915	8.743e-16	84.0	COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1SASQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_4128912_9	264732.Moth_1842	0.0002962	53.0	COG5662@1|root,COG5662@2|Bacteria,1VKS6@1239|Firmicutes,24VD1@186801|Clostridia	186801|Clostridia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
CMS2_k127_4128912_3	756272.Plabr_4092	7.135e-18	93.0	COG1595@1|root,COG1595@2|Bacteria,2J08Y@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_4128912_2	886293.Sinac_4705	8.755e-26	121.0	COG2834@1|root,COG2834@2|Bacteria,2J4MG@203682|Planctomycetes	203682|Planctomycetes	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4128912_7	1122963.AUHB01000008_gene3478	1.609e-11	71.0	COG1595@1|root,COG1595@2|Bacteria,1RE5E@1224|Proteobacteria,2V99M@28211|Alphaproteobacteria,370NS@31993|Methylocystaceae	28211|Alphaproteobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_4129349_1	1121430.JMLG01000013_gene1880	3.284e-233	740.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia,260TY@186807|Peptococcaceae	186801|Clostridia	C	Aconitase family (aconitate hydratase)	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
CMS2_k127_4129349_10	945713.IALB_2664	1.447e-27	118.0	COG1611@1|root,COG1611@2|Bacteria	2|Bacteria	S	cytokinin biosynthetic process	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS2_k127_4129349_7	756272.Plabr_3531	8.927e-100	343.0	COG0141@1|root,COG0141@2|Bacteria,2IXQ3@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
CMS2_k127_4129349_0	880073.Calab_1185	4.328e-256	819.0	COG0013@1|root,COG0013@2|Bacteria,2NNYC@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
CMS2_k127_4129349_4	886293.Sinac_5973	5.589e-135	438.0	COG0468@1|root,COG0468@2|Bacteria,2IX4U@203682|Planctomycetes	203682|Planctomycetes	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
CMS2_k127_4129349_9	56780.SYN_02029	2.035e-31	130.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,42TMM@68525|delta/epsilon subdivisions,2WQ6S@28221|Deltaproteobacteria,2MS94@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	LigT like Phosphoesterase	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
CMS2_k127_4129349_8	886293.Sinac_5975	1.001e-83	288.0	COG0524@1|root,COG0524@2|Bacteria,2IXGC@203682|Planctomycetes	203682|Planctomycetes	H	PFAM PfkB	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CMS2_k127_4129349_6	867903.ThesuDRAFT_00439	1.674e-110	377.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,3WCIN@538999|Clostridiales incertae sedis	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
CMS2_k127_4129349_5	497964.CfE428DRAFT_3513	1.747e-116	379.0	COG0684@1|root,COG0684@2|Bacteria,46SB3@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
CMS2_k127_4129349_3	880070.Cycma_2445	3.923e-143	469.0	COG0591@1|root,COG3055@1|root,COG0591@2|Bacteria,COG3055@2|Bacteria,4NEN8@976|Bacteroidetes,47UXG@768503|Cytophagia	976|Bacteroidetes	E	Sodium:solute symporter family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	Kelch_1,Kelch_5,Kelch_6,SSF
CMS2_k127_4129349_2	1242864.D187_004497	3.918e-166	529.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2YUA8@29|Myxococcales	28221|Deltaproteobacteria	J	glutaminyl-tRNA	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C
CMS2_k127_4145354_3	497964.CfE428DRAFT_1056	2.998e-118	396.0	COG3119@1|root,COG3119@2|Bacteria,46VGR@74201|Verrucomicrobia	74201|Verrucomicrobia	NP	Ig domain protein group 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Sulfatase
CMS2_k127_4145354_1	1396418.BATQ01000020_gene5035	3.561e-205	651.0	COG3119@1|root,COG3119@2|Bacteria,46ZJS@74201|Verrucomicrobia,2IVBK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_4145354_13	59374.Fisuc_2002	1.191e-10	76.0	COG3866@1|root,COG4733@1|root,COG3866@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Laminin_G_3,fn3
CMS2_k127_4145354_12	1122927.KB895431_gene78	3e-11	78.0	COG0383@1|root,COG2120@1|root,COG3210@1|root,COG4099@1|root,COG4733@1|root,COG5184@1|root,COG5276@1|root,COG0383@2|Bacteria,COG2120@2|Bacteria,COG3210@2|Bacteria,COG4099@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	3.2.1.24,3.4.24.40	ko:K01191,ko:K01406,ko:K20276	ko00511,ko01503,ko02024,map00511,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04131	-	GH38	-	Big_2,Cohesin,F5_F8_type_C,PIG-L,RCC1_2
CMS2_k127_4145354_4	1121904.ARBP01000025_gene6085	1.293e-32	148.0	COG2273@1|root,COG2730@1|root,COG3291@1|root,COG4733@1|root,COG5184@1|root,COG5492@1|root,COG2273@2|Bacteria,COG2730@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	chiA	-	3.2.1.4,3.2.1.73,3.2.1.80	ko:K01179,ko:K01216,ko:K03332,ko:K20276	ko00051,ko00500,ko01100,ko02024,map00051,map00500,map01100,map02024	-	R00879,R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Big_2,CBM_6,CHU_C,F5_F8_type_C,Glyco_hydro_16,PKD
CMS2_k127_4145354_14	411473.RUMCAL_01789	0.0003464	51.0	COG1842@1|root,COG1842@2|Bacteria,1UYNB@1239|Firmicutes,24CS3@186801|Clostridia,3WITU@541000|Ruminococcaceae	186801|Clostridia	KT	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
CMS2_k127_4145354_0	344747.PM8797T_19697	0.0	1791.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5,DUF3686
CMS2_k127_4145354_2	1294142.CINTURNW_1917	3.619e-204	655.0	COG2268@1|root,COG2268@2|Bacteria	2|Bacteria	T	Band 7 protein	yqiK	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
CMS2_k127_4145354_8	1499684.CCNP01000018_gene1968	2.831e-26	116.0	2A865@1|root,30X71@2|Bacteria,1VJDV@1239|Firmicutes,24IUY@186801|Clostridia,36IWA@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1449)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1449
CMS2_k127_4145354_9	203124.Tery_4082	8.945e-21	102.0	COG1842@1|root,COG1842@2|Bacteria,1G1GX@1117|Cyanobacteria,1H7D5@1150|Oscillatoriales	1117|Cyanobacteria	KT	Phage shock protein A (IM30) suppresses sigma54-dependent transcription	pspA	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
CMS2_k127_4145354_10	32057.KB217478_gene3808	3.454e-15	87.0	COG1842@1|root,COG1842@2|Bacteria,1G1GX@1117|Cyanobacteria,1HIIA@1161|Nostocales	1117|Cyanobacteria	KT	Phage shock protein A (IM30), suppresses sigma54-dependent transcription	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
CMS2_k127_4145354_7	1267534.KB906755_gene3903	9.66e-29	130.0	COG5544@1|root,COG5544@2|Bacteria	2|Bacteria	S	Lipoprotein	yfiM	-	-	ko:K05811	-	-	-	-	ko00000	-	-	-	DUF2279
CMS2_k127_4145354_6	203119.Cthe_2687	7.585e-30	124.0	COG1607@1|root,COG1607@2|Bacteria,1V3S2@1239|Firmicutes,24JIT@186801|Clostridia,3WJ94@541000|Ruminococcaceae	186801|Clostridia	I	thioesterase	yciA	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS2_k127_4145354_11	487796.Flav2ADRAFT_1065	2.84e-13	78.0	COG4935@1|root,COG4935@2|Bacteria,4NEN7@976|Bacteroidetes,1HWMS@117743|Flavobacteriia	976|Bacteroidetes	O	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,P_proprotein,Reprolysin_4,TSP_3
CMS2_k127_4145354_5	548479.HMPREF0573_11262	6.293e-30	129.0	2E2AR@1|root,32XG5@2|Bacteria	2|Bacteria	S	PFAM Pathogenesis-related transcriptional factor and ERF	-	-	-	-	-	-	-	-	-	-	-	-	AP2,HNH_3
CMS2_k127_4149661_0	452637.Oter_2196	1.467e-117	383.0	COG0673@1|root,COG0673@2|Bacteria,46U95@74201|Verrucomicrobia,3K969@414999|Opitutae	414999|Opitutae	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_4149661_4	1142394.PSMK_09490	2.148e-08	65.0	COG2165@1|root,COG2165@2|Bacteria,2IXM1@203682|Planctomycetes	203682|Planctomycetes	NU	Protein of unknown function (DUF1559)	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_4149661_1	497964.CfE428DRAFT_4416	3.961e-77	277.0	COG3119@1|root,COG3119@2|Bacteria,46U45@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_4149661_2	452637.Oter_2155	5.558e-22	95.0	COG2373@1|root,COG2373@2|Bacteria,46U24@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Alpha-2-macroglobulin family	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl
CMS2_k127_4164845_6	1121101.HMPREF1532_00978	8.827e-08	63.0	COG3119@1|root,COG3866@1|root,COG3119@2|Bacteria,COG3866@2|Bacteria,4NJUK@976|Bacteroidetes,2FR5P@200643|Bacteroidia,4ATC8@815|Bacteroidaceae	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4164845_4	1142394.PSMK_11030	7.303e-144	471.0	COG0285@1|root,COG0285@2|Bacteria,2IX24@203682|Planctomycetes	203682|Planctomycetes	H	folylpolyglutamate synthase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
CMS2_k127_4164845_7	309807.SRU_0587	4.751e-07	54.0	COG2250@1|root,COG2250@2|Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_4164845_2	886293.Sinac_0260	1.906e-162	526.0	COG1070@1|root,COG1070@2|Bacteria,2IXYW@203682|Planctomycetes	203682|Planctomycetes	G	COG1070 Sugar (pentulose and hexulose)	-	-	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
CMS2_k127_4164845_5	926550.CLDAP_32170	7.984e-114	384.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604,DUF5011,SLH
CMS2_k127_4164845_3	1120942.AUBM01000010_gene1308	6.902e-147	483.0	COG1063@1|root,COG1063@2|Bacteria,2H3Y2@201174|Actinobacteria,4D42Y@85005|Actinomycetales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	ko:K19956	ko00051,map00051	-	R03234	RC00089	ko00000,ko00001,ko01000	-	-	-	ADH_N
CMS2_k127_4164845_1	1304880.JAGB01000001_gene487	5.849e-177	562.0	COG4030@1|root,COG4030@2|Bacteria,1TRZY@1239|Firmicutes,249GP@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
CMS2_k127_4164845_0	1499967.BAYZ01000095_gene4060	2.465e-196	622.0	COG4806@1|root,COG4806@2|Bacteria	2|Bacteria	G	L-rhamnose isomerase activity	rhaA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008270,GO:0008740,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019324,GO:0022607,GO:0030145,GO:0030246,GO:0032991,GO:0033296,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046872,GO:0046914,GO:0048029,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901575	2.7.1.5,5.3.1.14	ko:K00848,ko:K01813	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R02437,R03014	RC00002,RC00017,RC00434	ko00000,ko00001,ko01000	-	-	iECIAI39_1322.ECIAI39_3092,iUMNK88_1353.UMNK88_4739	RhaA
CMS2_k127_417293_8	530564.Psta_3630	2.934e-45	179.0	COG4972@1|root,COG4972@2|Bacteria,2IZC6@203682|Planctomycetes	203682|Planctomycetes	NU	pilus assembly protein	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
CMS2_k127_417293_15	314230.DSM3645_24265	1.468e-06	58.0	COG4970@1|root,COG4970@2|Bacteria,2J1P5@203682|Planctomycetes	203682|Planctomycetes	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
CMS2_k127_417293_13	1122609.AUGT01000008_gene2868	8.529e-17	94.0	COG0366@1|root,COG0515@1|root,COG2133@1|root,COG3227@1|root,COG4733@1|root,COG0366@2|Bacteria,COG0515@2|Bacteria,COG2133@2|Bacteria,COG3227@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.3	ko:K01178,ko:K14645,ko:K18546	ko00500,ko01100,ko02024,map00500,map01100,map02024	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH15	-	Alpha-amylase,GSDH,He_PIG,PKD,Pro_Al_protease,SLH,Trypsin,fn3
CMS2_k127_417293_11	521674.Plim_3351	4.531e-25	110.0	COG2165@1|root,COG2165@2|Bacteria,2J10X@203682|Planctomycetes	203682|Planctomycetes	U	Pfam:N_methyl_2	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_417293_12	344747.PM8797T_11234	1.779e-20	101.0	COG2165@1|root,COG2165@2|Bacteria,2J10X@203682|Planctomycetes	203682|Planctomycetes	U	Pfam:N_methyl_2	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_417293_10	1121405.dsmv_0207	4.468e-29	128.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,42VU4@68525|delta/epsilon subdivisions,2WQBA@28221|Deltaproteobacteria,2MKGC@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	yjeE	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
CMS2_k127_417293_3	385682.AFSL01000012_gene2848	4.322e-119	410.0	COG3401@1|root,COG3401@2|Bacteria,4NFM5@976|Bacteroidetes,2FPSM@200643|Bacteroidia	976|Bacteroidetes	S	candidate rhamnogalacturonan lyase, polysaccharide lyase family 11 protein K01238	-	-	4.2.2.23	ko:K18197	-	-	-	-	ko00000,ko01000	-	PL11	-	-
CMS2_k127_417293_6	247490.KSU1_D0414	3.707e-60	220.0	COG0611@1|root,COG0611@2|Bacteria,2IZG9@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
CMS2_k127_417293_2	247490.KSU1_D0616	6.648e-140	459.0	COG0165@1|root,COG0165@2|Bacteria,2IWV5@203682|Planctomycetes	203682|Planctomycetes	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
CMS2_k127_417293_4	1501230.ET33_36130	1.223e-80	282.0	COG1820@1|root,COG1820@2|Bacteria,1TPFK@1239|Firmicutes,4HC6C@91061|Bacilli,26RVP@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	-	-	3.5.1.25	ko:K01443,ko:K16786,ko:K16787	ko00520,ko01130,ko02010,map00520,map01130,map02010	M00582	R02059	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	Amidohydro_1
CMS2_k127_417293_0	344747.PM8797T_15341	2.074e-143	465.0	2DV29@1|root,33TNQ@2|Bacteria	2|Bacteria	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_417293_1	1121405.dsmv_0645	2.465e-140	453.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,42MZS@68525|delta/epsilon subdivisions,2WIQP@28221|Deltaproteobacteria,2MHR8@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Beta-eliminating lyase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
CMS2_k127_417293_9	552811.Dehly_1300	3.915e-38	154.0	COG0655@1|root,COG0655@2|Bacteria,2GAKP@200795|Chloroflexi,34CPA@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS2_k127_417293_5	314230.DSM3645_08617	6.986e-66	239.0	COG0009@1|root,COG0394@1|root,COG0009@2|Bacteria,COG0394@2|Bacteria,2IX5F@203682|Planctomycetes	203682|Planctomycetes	T	Belongs to the SUA5 family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc,Sua5_yciO_yrdC
CMS2_k127_417293_7	1123242.JH636436_gene464	2.421e-49	180.0	COG0698@1|root,COG0698@2|Bacteria,2IZKI@203682|Planctomycetes	203682|Planctomycetes	G	COG0698 Ribose 5-phosphate isomerase RpiB	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
CMS2_k127_417293_14	1304888.ATWF01000001_gene619	8.589e-09	59.0	COG0825@1|root,COG0825@2|Bacteria,2GEY1@200930|Deferribacteres	200930|Deferribacteres	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
CMS2_k127_4175022_4	1410620.SHLA_36c000140	2.392e-55	195.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_4175022_10	755178.Cyan10605_2018	8.19e-06	53.0	COG1669@1|root,COG1669@2|Bacteria,1G7T8@1117|Cyanobacteria	1117|Cyanobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CMS2_k127_4175022_9	237368.SCABRO_00865	1.232e-06	53.0	COG1895@1|root,COG1895@2|Bacteria,2J4E4@203682|Planctomycetes	203682|Planctomycetes	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_4175022_5	743722.Sph21_3064	7.814e-46	177.0	COG0500@1|root,COG0500@2|Bacteria,4NGY5@976|Bacteroidetes,1J0S7@117747|Sphingobacteriia	976|Bacteroidetes	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS2_k127_4175022_7	1238182.C882_3643	1.047e-24	107.0	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2U9U2@28211|Alphaproteobacteria,2JQ4Q@204441|Rhodospirillales	204441|Rhodospirillales	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
CMS2_k127_4175022_0	313628.LNTAR_21530	1.754e-227	731.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,CBM_35,F5_F8_type_C,GDE_C,NPCBM_assoc,RicinB_lectin_2,Trehalase
CMS2_k127_4175022_1	272559.BF9343_3219	8.121e-116	404.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	nanA	GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Gram_pos_anchor,Sialidase,YSIRK_signal
CMS2_k127_4175022_3	344747.PM8797T_25041	1.366e-74	261.0	COG1082@1|root,COG1082@2|Bacteria,2IXXX@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase-like TIM barrel	-	-	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	AP_endonuc_2
CMS2_k127_4175022_2	1321778.HMPREF1982_04695	1.056e-110	379.0	COG0249@1|root,COG0249@2|Bacteria,1TPJP@1239|Firmicutes,247IW@186801|Clostridia,26AD6@186813|unclassified Clostridiales	186801|Clostridia	L	ATPase domain of DNA mismatch repair MUTS family	mutS2	-	-	-	-	-	-	-	-	-	-	-	MutS_III,MutS_V
CMS2_k127_4175022_8	56110.Oscil6304_0361	4.805e-13	80.0	COG0457@1|root,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria	1117|Cyanobacteria	M	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
CMS2_k127_4175022_6	880072.Desac_1041	1.281e-30	121.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2WIQ5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
CMS2_k127_4179882_14	765912.Thimo_2466	5.515e-33	136.0	COG4566@1|root,COG4566@2|Bacteria,1RGE8@1224|Proteobacteria,1S4T1@1236|Gammaproteobacteria,1X2B8@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS2_k127_4179882_0	706587.Desti_2763	1.233e-260	817.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MR3P@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	PFAM Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
CMS2_k127_4179882_1	589865.DaAHT2_1111	6.716e-249	786.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
CMS2_k127_4179882_2	589865.DaAHT2_1112	5.616e-206	658.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MI87@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3
CMS2_k127_4179882_13	574087.Acear_0362	1.118e-38	162.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,3WAC6@53433|Halanaerobiales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,Fer4_7,Fer4_9,NQRA_SLBB,RnfC_N
CMS2_k127_4179882_9	574087.Acear_0363	3.184e-95	323.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,3WA9X@53433|Halanaerobiales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	-	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
CMS2_k127_4179882_15	391598.FBBAL38_07470	5.536e-29	123.0	COG2869@1|root,COG2869@2|Bacteria,4NF7A@976|Bacteroidetes,1HZG0@117743|Flavobacteriia	976|Bacteroidetes	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
CMS2_k127_4179882_11	675813.VIB_000637	9.647e-62	220.0	COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,1XSX6@135623|Vibrionales	135623|Vibrionales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrD	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0044464,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0098796,GO:1902494	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
CMS2_k127_4179882_10	293826.Amet_3189	8.462e-69	238.0	COG2209@1|root,COG2209@2|Bacteria,1UYUQ@1239|Firmicutes,24CMI@186801|Clostridia,36RAD@31979|Clostridiaceae	186801|Clostridia	C	Rnf-Nqr subunit, membrane protein	-	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
CMS2_k127_4179882_8	1123274.KB899408_gene3929	9.444e-100	336.0	COG2871@1|root,COG2871@2|Bacteria,2JBKD@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase FAD-binding domain	-	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
CMS2_k127_4179882_3	383372.Rcas_3915	1.218e-190	616.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	amy	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
CMS2_k127_4179882_4	880070.Cycma_4136	1.283e-190	606.0	COG4948@1|root,COG4948@2|Bacteria,4NE9A@976|Bacteroidetes,47NDY@768503|Cytophagia	976|Bacteroidetes	M	Mandelate racemase / muconate lactonizing enzyme, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
CMS2_k127_4179882_5	313603.FB2170_04525	8.137e-131	427.0	COG0684@1|root,COG0684@2|Bacteria,4NF3M@976|Bacteroidetes,1HZ8J@117743|Flavobacteriia,2PHRX@252356|Maribacter	976|Bacteroidetes	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
CMS2_k127_4179882_17	1123242.JH636435_gene3031	1.223e-10	71.0	COG2165@1|root,COG2165@2|Bacteria,2J1VA@203682|Planctomycetes	203682|Planctomycetes	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_4179882_16	1229204.AMYY01000008_gene1819	4.376e-21	109.0	COG0793@1|root,COG0793@2|Bacteria,1R7I0@1224|Proteobacteria,2U0JI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Peptidase family S41	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S41,Tricorn_C1
CMS2_k127_4179882_18	7918.ENSLOCP00000009491	1.673e-05	58.0	COG0666@1|root,KOG0504@2759|Eukaryota,39S8I@33154|Opisthokonta,3BKQB@33208|Metazoa,3D0U5@33213|Bilateria,485C5@7711|Chordata,49692@7742|Vertebrata,49QI5@7898|Actinopterygii	33208|Metazoa	S	and ankyrin repeat domains 1	FANK1	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005929,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010941,GO:0010942,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031974,GO:0031981,GO:0042981,GO:0042995,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044093,GO:0044422,GO:0044424,GO:0044428,GO:0044441,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051090,GO:0051091,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0060548,GO:0065007,GO:0065009,GO:0070013,GO:0080090,GO:0097546,GO:0120025,GO:0120038,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_4,Ank_5
CMS2_k127_4179882_12	583355.Caka_0705	3.165e-48	175.0	COG0673@1|root,COG0673@2|Bacteria,46U95@74201|Verrucomicrobia,3K969@414999|Opitutae	414999|Opitutae	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_4179882_7	583355.Caka_0705	2.5e-124	406.0	COG0673@1|root,COG0673@2|Bacteria,46U95@74201|Verrucomicrobia,3K969@414999|Opitutae	414999|Opitutae	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_4179882_6	1195236.CTER_4883	8.069e-128	431.0	COG2006@1|root,COG2006@2|Bacteria,1VRZ8@1239|Firmicutes,24Z9V@186801|Clostridia,3WN5G@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Dockerin_1
CMS2_k127_4184208_7	1121405.dsmv_3372	8.722e-45	178.0	COG1141@1|root,COG2878@1|root,COG1141@2|Bacteria,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,42PTG@68525|delta/epsilon subdivisions,2WKYG@28221|Deltaproteobacteria,2MIM0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_7
CMS2_k127_4184208_5	1499967.BAYZ01000102_gene3568	7.016e-58	216.0	COG4657@1|root,COG4657@2|Bacteria,2NPB0@2323|unclassified Bacteria	2|Bacteria	U	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
CMS2_k127_4184208_4	879212.DespoDRAFT_02017	9.318e-60	213.0	COG4660@1|root,COG4660@2|Bacteria,1R4EB@1224|Proteobacteria,42PW0@68525|delta/epsilon subdivisions,2WKTN@28221|Deltaproteobacteria,2MJEI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the NqrDE RnfAE family	-	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
CMS2_k127_4184208_10	1321784.HMPREF1987_02220	3.113e-10	69.0	COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,24JVM@186801|Clostridia	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
CMS2_k127_4184208_3	1121918.ARWE01000001_gene21	4.104e-74	261.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,42QE5@68525|delta/epsilon subdivisions,2WM8R@28221|Deltaproteobacteria,43S58@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NQR2, RnfD, RnfE family	-	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
CMS2_k127_4184208_2	177437.HRM2_23770	1.567e-112	383.0	COG4656@1|root,COG4656@2|Bacteria,1PJE1@1224|Proteobacteria,42P69@68525|delta/epsilon subdivisions,2WIM9@28221|Deltaproteobacteria,2MI2H@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB
CMS2_k127_4184208_6	338963.Pcar_1212	2.678e-45	179.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,42P1P@68525|delta/epsilon subdivisions,2WJ99@28221|Deltaproteobacteria,43VZN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TAT_signal,TPR_16,TPR_19
CMS2_k127_4184208_9	748449.Halha_0117	1.955e-14	85.0	COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,248XQ@186801|Clostridia,3WC2I@53433|Halanaerobiales	186801|Clostridia	S	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_4184208_0	522772.Dacet_2325	5.97e-157	508.0	COG0112@1|root,COG0112@2|Bacteria,2GERI@200930|Deferribacteres	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
CMS2_k127_4184208_8	521674.Plim_0675	2.136e-24	120.0	COG0457@1|root,COG0457@2|Bacteria,2J01V@203682|Planctomycetes	203682|Planctomycetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
CMS2_k127_4184208_11	1458462.JNLK01000001_gene217	1.381e-06	54.0	COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,24QNX@186801|Clostridia,27PVR@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
CMS2_k127_4184208_1	314230.DSM3645_20407	1.72e-133	449.0	COG0557@1|root,COG0557@2|Bacteria,2IX1J@203682|Planctomycetes	203682|Planctomycetes	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
CMS2_k127_4198333_15	756272.Plabr_3296	4.687e-42	157.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_4198333_2	1396418.BATQ01000109_gene4730	6.505e-175	560.0	COG0673@1|root,COG0673@2|Bacteria,46TMZ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_4198333_0	706587.Desti_2509	3.105e-263	832.0	COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria,1MX2U@1224|Proteobacteria,42QJC@68525|delta/epsilon subdivisions,2WPI2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_10,TPR_16,TPR_19,TPR_4,TPR_8
CMS2_k127_4198333_19	1168034.FH5T_16920	4.509e-09	68.0	2E19M@1|root,32WPW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4198333_18	1117379.BABA_10891	7.437e-28	126.0	COG0746@1|root,COG0746@2|Bacteria,1VA6T@1239|Firmicutes,4HPX3@91061|Bacilli,1ZIA7@1386|Bacillus	91061|Bacilli	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS2_k127_4198333_6	1408473.JHXO01000010_gene3618	1.541e-96	329.0	COG0303@1|root,COG0303@2|Bacteria,4NDYD@976|Bacteroidetes	976|Bacteroidetes	H	Molybdenum cofactor synthesis domain	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
CMS2_k127_4198333_7	1121468.AUBR01000023_gene2764	8.588e-79	273.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia,42ES4@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
CMS2_k127_4198333_16	911045.PSE_3387	4.535e-33	141.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
CMS2_k127_4198333_12	643648.Slip_0570	4.964e-48	177.0	COG2258@1|root,COG2258@2|Bacteria,1V6DS@1239|Firmicutes,24HBA@186801|Clostridia,42K1R@68298|Syntrophomonadaceae	186801|Clostridia	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
CMS2_k127_4198333_13	1111479.AXAR01000010_gene2612	8.077e-47	173.0	COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,4HHPP@91061|Bacilli,278GY@186823|Alicyclobacillaceae	91061|Bacilli	H	Probable molybdopterin binding domain	moaB	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
CMS2_k127_4198333_4	1128427.KB904821_gene1028	2.635e-126	449.0	COG3250@1|root,COG3250@2|Bacteria,1G4FY@1117|Cyanobacteria,1HA7W@1150|Oscillatoriales	1117|Cyanobacteria	G	Glycosyl hydrolases family 2	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
CMS2_k127_4198333_8	1396141.BATP01000043_gene1929	3.391e-77	297.0	COG5337@1|root,COG5337@2|Bacteria,46ZJW@74201|Verrucomicrobia,2IVD0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH,LTD
CMS2_k127_4198333_9	1385514.N782_15215	2.561e-65	235.0	COG1082@1|root,COG1082@2|Bacteria,1UITG@1239|Firmicutes,4HFIC@91061|Bacilli	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
CMS2_k127_4198333_11	1303518.CCALI_02088	9.938e-51	185.0	COG3822@1|root,COG3822@2|Bacteria	2|Bacteria	S	D-lyxose isomerase	Z012_00995	-	5.3.1.15	ko:K09988	ko00040,map00040	-	R01898	RC00516	ko00000,ko00001,ko01000	-	-	-	Lyx_isomer
CMS2_k127_4198333_3	595460.RRSWK_04510	6.255e-167	537.0	COG2271@1|root,COG2271@2|Bacteria,2IZ4G@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	ko:K03535	-	-	-	-	ko00000,ko02000	2.A.1.14.1	-	-	MFS_1
CMS2_k127_4198333_10	35703.DQ02_11580	1.618e-54	201.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,1RRUP@1236|Gammaproteobacteria,3WY10@544|Citrobacter	1236|Gammaproteobacteria	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
CMS2_k127_4198333_17	688270.Celal_3276	2.552e-31	143.0	29Y23@1|root,30JV2@2|Bacteria,4PHZ7@976|Bacteroidetes,1IG75@117743|Flavobacteriia,1FAJM@104264|Cellulophaga	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4198333_1	485917.Phep_2408	1.6e-226	724.0	COG5652@1|root,COG5652@2|Bacteria,4NIE7@976|Bacteroidetes	976|Bacteroidetes	S	Heparinase II/III-like protein	-	GO:0003674,GO:0003824,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006082,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008201,GO:0009056,GO:0009057,GO:0009987,GO:0016829,GO:0016835,GO:0016837,GO:0030202,GO:0030203,GO:0030211,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044464,GO:0047488,GO:0071704,GO:0097367,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1901681,GO:1903510	4.2.2.7,4.2.2.8	ko:K19051	-	-	-	-	ko00000,ko01000	-	PL21	-	DUF4962,Hepar_II_III
CMS2_k127_4198333_14	886293.Sinac_6718	4.093e-46	187.0	2EDSX@1|root,337NB@2|Bacteria,2J11B@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4198333_5	886293.Sinac_7507	5.405e-111	376.0	COG5267@1|root,COG5267@2|Bacteria,2IYR3@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
CMS2_k127_4256486_2	530564.Psta_2436	2.421e-49	180.0	COG1530@1|root,COG1530@2|Bacteria,2IWSS@203682|Planctomycetes	203682|Planctomycetes	J	TIGRFAM ribonuclease, Rne Rng family	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
CMS2_k127_4256486_8	485916.Dtox_3327	9.401e-16	87.0	COG5011@1|root,COG5011@2|Bacteria,1V4D0@1239|Firmicutes,249GU@186801|Clostridia,261TK@186807|Peptococcaceae	186801|Clostridia	S	protein conserved in bacteria (DUF2344)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
CMS2_k127_4256486_0	247490.KSU1_C0159	1.131e-173	562.0	COG1080@1|root,COG1080@2|Bacteria,2IX08@203682|Planctomycetes	203682|Planctomycetes	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr
CMS2_k127_4256486_7	575540.Isop_1108	4.921e-16	81.0	COG1925@1|root,COG1925@2|Bacteria,2J0PZ@203682|Planctomycetes	203682|Planctomycetes	G	Phosphotransferase System	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
CMS2_k127_4256486_4	344747.PM8797T_06922	1.469e-35	145.0	COG1762@1|root,COG1762@2|Bacteria,2IZ73@203682|Planctomycetes	203682|Planctomycetes	G	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	-	-	2.7.1.202	ko:K02768,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
CMS2_k127_4256486_10	1123519.PSJM300_03805	3.386e-08	61.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1Z379@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	COG1544 Ribosome-associated protein Y (PSrp-1)	yhbH	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
CMS2_k127_4256486_3	1142394.PSMK_02370	4.52e-43	167.0	COG2928@1|root,COG2928@2|Bacteria,2IZGR@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
CMS2_k127_4256486_5	637389.Acaty_c2094	7.474e-27	123.0	COG0392@1|root,COG0392@2|Bacteria,1MVZ8@1224|Proteobacteria,1SDDS@1236|Gammaproteobacteria,2NC9Y@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS2_k127_4256486_1	478741.JAFS01000002_gene516	6.559e-50	181.0	COG0139@1|root,COG0139@2|Bacteria,46SZA@74201|Verrucomicrobia,37GK9@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
CMS2_k127_4256486_6	331678.Cphamn1_0511	3.234e-24	112.0	28PPG@1|root,2ZCBV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
CMS2_k127_4256486_9	1304880.JAGB01000002_gene2414	2.59e-12	71.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,25B5Z@186801|Clostridia	186801|Clostridia	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD,Redoxin
CMS2_k127_4256486_11	1122983.BAJY01000043_gene2357	0.000243	52.0	COG0526@1|root,COG0526@2|Bacteria,4NS1W@976|Bacteroidetes,2G2XE@200643|Bacteroidia	976|Bacteroidetes	CO	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin,Thioredoxin_8
CMS2_k127_4260577_7	1122611.KB904018_gene7079	5.903e-22	106.0	COG2755@1|root,COG3055@1|root,COG3209@1|root,COG2755@2|Bacteria,COG3055@2|Bacteria,COG3209@2|Bacteria,2IH7Z@201174|Actinobacteria,4EKQ8@85012|Streptosporangiales	201174|Actinobacteria	M	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS2_k127_4260577_8	335541.Swol_1076	1.69e-13	74.0	COG5492@1|root,COG5492@2|Bacteria,1V7TS@1239|Firmicutes,25F4B@186801|Clostridia,42KX4@68298|Syntrophomonadaceae	2|Bacteria	N	Surface proteins containing Ig-like domains-like	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CBM_X2,CHB_HEX_C_1,Flg_new,Glug,SLH
CMS2_k127_4260577_3	861299.J421_3262	3.991e-77	268.0	COG4974@1|root,COG4974@2|Bacteria,1ZTAH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS2_k127_4260577_1	379066.GAU_0871	3.731e-196	618.0	COG0050@1|root,COG0050@2|Bacteria,1ZSZD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
CMS2_k127_4260577_9	886293.Sinac_0509	8.341e-12	68.0	COG0267@1|root,COG0267@2|Bacteria,2J1HX@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
CMS2_k127_4260577_10	1142394.PSMK_08330	3.51e-11	68.0	COG0690@1|root,COG0690@2|Bacteria,2J0E7@203682|Planctomycetes	203682|Planctomycetes	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
CMS2_k127_4260577_5	1142394.PSMK_08340	1.842e-55	199.0	COG0250@1|root,COG0250@2|Bacteria,2IZ9N@203682|Planctomycetes	203682|Planctomycetes	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
CMS2_k127_4260577_4	575540.Isop_0109	1.197e-55	197.0	COG0080@1|root,COG0080@2|Bacteria,2IZ97@203682|Planctomycetes	203682|Planctomycetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
CMS2_k127_4260577_2	247490.KSU1_C1198	1.972e-77	265.0	COG0081@1|root,COG0081@2|Bacteria,2IYQK@203682|Planctomycetes	203682|Planctomycetes	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
CMS2_k127_4260577_11	390333.Ldb1658	1.839e-10	69.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,4HH0N@91061|Bacilli,3F4S4@33958|Lactobacillaceae	91061|Bacilli	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
CMS2_k127_4260577_6	344747.PM8797T_12146	3.533e-43	162.0	COG0222@1|root,COG0222@2|Bacteria,2J0AK@203682|Planctomycetes	203682|Planctomycetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
CMS2_k127_4260577_0	1142394.PSMK_24450	4.191e-201	639.0	COG0085@1|root,COG0085@2|Bacteria,2IXVZ@203682|Planctomycetes	203682|Planctomycetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
CMS2_k127_4285805_1	485918.Cpin_2602	2.103e-172	576.0	COG3119@1|root,COG3119@2|Bacteria,4NEPB@976|Bacteroidetes,1IW05@117747|Sphingobacteriia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_4285805_2	880073.Calab_1812	2.447e-143	467.0	COG4948@1|root,COG4948@2|Bacteria,2NP34@2323|unclassified Bacteria	2|Bacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	ykfB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564	4.2.1.113,5.1.1.20	ko:K02549,ko:K19802	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031,R10938	RC01053,RC03309	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
CMS2_k127_4285805_5	56780.SYN_01766	2.427e-69	243.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2WK5J@28221|Deltaproteobacteria,2MQ5V@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS2_k127_4285805_4	880072.Desac_2551	1.492e-72	251.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,42N6I@68525|delta/epsilon subdivisions,2WK7S@28221|Deltaproteobacteria,2MQG1@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
CMS2_k127_4285805_6	426114.THI_3085	4.171e-40	170.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria	28216|Betaproteobacteria	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	-	-	1.8.1.8	ko:K04084,ko:K08344	-	-	-	-	ko00000,ko01000,ko02000,ko03110	5.A.1.1,5.A.1.5	-	-	DsbC,DsbD,Thioredoxin_7
CMS2_k127_4285805_0	1142394.PSMK_25340	3.472e-199	642.0	COG0465@1|root,COG0465@2|Bacteria,2IWU2@203682|Planctomycetes	203682|Planctomycetes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CMS2_k127_4285805_7	247490.KSU1_C1008	3.278e-20	100.0	COG2980@1|root,COG2980@2|Bacteria,2J0MT@203682|Planctomycetes	203682|Planctomycetes	M	Lipopolysaccharide-assembly	-	-	-	-	-	-	-	-	-	-	-	-	LptE
CMS2_k127_4285805_8	1142394.PSMK_25110	2.428e-13	81.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	TPR_16,TPR_6,YfiO
CMS2_k127_4285805_3	435591.BDI_1656	2.345e-73	260.0	COG1397@1|root,COG1397@2|Bacteria,4NG36@976|Bacteroidetes,2FNB7@200643|Bacteroidia,22X71@171551|Porphyromonadaceae	976|Bacteroidetes	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
CMS2_k127_4290873_1	552811.Dehly_0763	1.449e-37	151.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G8XD@200795|Chloroflexi,34CY9@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
CMS2_k127_4290873_3	1200792.AKYF01000020_gene4802	6.613e-18	84.0	2EH45@1|root,33AW4@2|Bacteria,1VF2V@1239|Firmicutes,4HP8P@91061|Bacilli,26ZU5@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4290873_2	1396141.BATP01000019_gene1625	3.071e-21	97.0	COG0515@1|root,COG0515@2|Bacteria,46X96@74201|Verrucomicrobia,2IV2P@203494|Verrucomicrobiae	1396141.BATP01000019_gene1625|-	KLT	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4290873_5	1210884.HG799465_gene11632	5.278e-11	66.0	COG0515@1|root,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS2_k127_4290873_0	1210884.HG799465_gene11632	4.988e-84	309.0	COG0515@1|root,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS2_k127_4290873_4	1123508.JH636443_gene4732	2.402e-14	86.0	COG0515@1|root,COG0515@2|Bacteria,2J2C5@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS2_k127_4293564_3	794903.OPIT5_23075	2.279e-10	72.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_4293564_5	1120936.KB907223_gene2458	4.244e-05	52.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4EMQS@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS2_k127_4293564_0	1123277.KB893195_gene5637	3.359e-104	347.0	COG3394@1|root,COG3394@2|Bacteria,4NFY5@976|Bacteroidetes,47MN2@768503|Cytophagia	976|Bacteroidetes	G	YdjC-like protein	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
CMS2_k127_4293564_1	338963.Pcar_1478	5.403e-53	198.0	COG1418@1|root,COG1418@2|Bacteria,1RK7K@1224|Proteobacteria,42SRK@68525|delta/epsilon subdivisions,2WP5I@28221|Deltaproteobacteria,43UQH@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Metal-dependent phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS2_k127_4293564_2	167539.Pro_1558	7.956e-27	111.0	COG3450@1|root,COG3450@2|Bacteria,1G7YR@1117|Cyanobacteria,1MMR6@1212|Prochloraceae	1117|Cyanobacteria	S	Alternative locus ID	-	-	-	ko:K06995	-	-	-	-	ko00000	-	-	-	Cupin_3
CMS2_k127_4293564_4	246197.MXAN_4123	1.46e-07	63.0	COG4677@1|root,COG4677@2|Bacteria,1PXT2@1224|Proteobacteria,434TW@68525|delta/epsilon subdivisions,2WZ4T@28221|Deltaproteobacteria,2Z1BV@29|Myxococcales	28221|Deltaproteobacteria	G	pectinesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	NosD
CMS2_k127_4315915_4	314285.KT71_13669	3.298e-78	270.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23,HlyD_D4,YtkA
CMS2_k127_4315915_2	314285.KT71_14209	9.601e-85	297.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,1RRRP@1236|Gammaproteobacteria,1JAPF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	MU	Outer membrane efflux protein	cebC	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_4315915_3	886293.Sinac_7025	9.798e-82	282.0	COG1225@1|root,COG1225@2|Bacteria,2IYHT@203682|Planctomycetes	203682|Planctomycetes	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS2_k127_4315915_1	290397.Adeh_2843	5.391e-99	333.0	COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,42UGV@68525|delta/epsilon subdivisions,2WR1G@28221|Deltaproteobacteria,2YUDE@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS2_k127_4315915_0	344747.PM8797T_19106	7.038e-130	424.0	COG1520@1|root,COG1520@2|Bacteria,2IWWY@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_4352634_2	1123508.JH636443_gene5100	1.101e-12	76.0	COG1366@1|root,COG1366@2|Bacteria,2J02R@203682|Planctomycetes	203682|Planctomycetes	T	Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS2_k127_4352634_1	1177594.MIC448_830010	1.78e-25	120.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CarboxypepD_reg,HemolysinCabind
CMS2_k127_4352634_0	572477.Alvin_0936	1.592e-163	537.0	COG0443@1|root,COG0443@2|Bacteria,1NKBW@1224|Proteobacteria,1SQMM@1236|Gammaproteobacteria,1X11D@135613|Chromatiales	135613|Chromatiales	O	Hsp70 protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
CMS2_k127_4354474_1	497964.CfE428DRAFT_4943	5.792e-118	396.0	COG0577@1|root,COG0577@2|Bacteria,46U6N@74201|Verrucomicrobia	74201|Verrucomicrobia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
CMS2_k127_4354474_4	497964.CfE428DRAFT_4944	1.077e-72	258.0	COG1136@1|root,COG1136@2|Bacteria,46V6W@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS2_k127_4354474_2	1168034.FH5T_01525	5.838e-112	378.0	COG0438@1|root,COG0438@2|Bacteria,4P10Z@976|Bacteroidetes	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
CMS2_k127_4354474_3	497964.CfE428DRAFT_5038	3.545e-108	370.0	COG1520@1|root,COG1520@2|Bacteria,46T0C@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
CMS2_k127_4354474_0	316067.Geob_0375	0.0	1669.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,43TSH@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	por	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
CMS2_k127_4372278_9	1123070.KB899251_gene797	0.0001339	55.0	COG4625@1|root,COG4625@2|Bacteria	2|Bacteria	T	pathogenesis	-	-	4.2.2.23	ko:K06972,ko:K18195	-	-	-	-	ko00000,ko01000,ko01002	-	PL4	-	Autotransporter,CBM-like,DUF285,Flg_new,SLH,fn3_3
CMS2_k127_4372278_6	697281.Mahau_0770	2.09e-09	71.0	28HEJ@1|root,2Z7QZ@2|Bacteria,1VVD9@1239|Firmicutes,250PS@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4185)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185
CMS2_k127_4372278_7	459349.CLOAM0895	2.521e-08	68.0	COG1361@1|root,COG1404@1|root,COG4412@1|root,COG1361@2|Bacteria,COG1404@2|Bacteria,COG4412@2|Bacteria,2NREM@2323|unclassified Bacteria	2|Bacteria	O	Evidence 5 No homology to any previously reported sequences	-	-	3.4.17.22	ko:K07752	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Calx-beta,DUF4859,FlgD_ig,VCBS
CMS2_k127_4372278_8	697281.Mahau_0770	4.34e-05	57.0	28HEJ@1|root,2Z7QZ@2|Bacteria,1VVD9@1239|Firmicutes,250PS@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4185)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185
CMS2_k127_4372278_4	543632.JOJL01000002_gene8009	6.149e-24	119.0	COG2755@1|root,COG5434@1|root,COG2755@2|Bacteria,COG5434@2|Bacteria,2II7D@201174|Actinobacteria,4D8ZD@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyl hydrolases family 28	-	-	-	-	-	-	-	-	-	-	-	-	Alpha_L_fucos,CBM_35,F5_F8_type_C,Glyco_hydro_28,Pectate_lyase_3
CMS2_k127_4372278_2	485918.Cpin_4822	4.888e-32	145.0	COG0383@1|root,COG0383@2|Bacteria,4NIM9@976|Bacteroidetes,1IR3M@117747|Sphingobacteriia	976|Bacteroidetes	G	glycoside hydrolase family 38	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
CMS2_k127_4372278_5	243090.RB7625	1.149e-13	75.0	COG2610@1|root,COG2610@2|Bacteria,2J1TI@203682|Planctomycetes	203682|Planctomycetes	EG	COG2610 H gluconate symporter and related permeases	-	-	-	-	-	-	-	-	-	-	-	-	GntP_permease
CMS2_k127_4372278_10	344747.PM8797T_30556	0.0009967	46.0	COG4221@1|root,COG4221@2|Bacteria,2IYVR@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS2_k127_4372278_1	1142394.PSMK_11840	8.955e-72	263.0	COG3534@1|root,COG3534@2|Bacteria	2|Bacteria	G	alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
CMS2_k127_4372278_3	1028307.EAE_11970	6.555e-26	125.0	COG1874@1|root,COG1874@2|Bacteria,1PBWS@1224|Proteobacteria,1RYV8@1236|Gammaproteobacteria,3X3DI@547|Enterobacter	1236|Gammaproteobacteria	G	Domain of unknown function (DUF4832)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4832,Glyco_hydro_42
CMS2_k127_4372278_0	649831.L083_3386	1.948e-100	345.0	COG1653@1|root,COG1653@2|Bacteria,2HT29@201174|Actinobacteria,4DI81@85008|Micromonosporales	201174|Actinobacteria	G	Protein of unknown function (DUF1565)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF1565
CMS2_k127_4392250_3	1303518.CCALI_02497	3.405e-14	80.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038,RicinB_lectin_2
CMS2_k127_4392250_1	1122933.JNIY01000008_gene1762	2.749e-68	260.0	2C0ZI@1|root,2ZAKK@2|Bacteria,2GMTZ@201174|Actinobacteria	201174|Actinobacteria	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4962,Hepar_II_III
CMS2_k127_4392250_0	641524.ADICYQ_0054	5.043e-180	575.0	COG1680@1|root,COG1680@2|Bacteria,4P124@976|Bacteroidetes	976|Bacteroidetes	V	COG1680 Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185
CMS2_k127_4392250_2	452637.Oter_2946	1.541e-24	108.0	COG5512@1|root,COG5512@2|Bacteria	2|Bacteria	L	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	Collagen_bind_2,DUF4038,DUF5060,DUF721
CMS2_k127_4394562_3	240016.ABIZ01000001_gene2777	8.131e-24	109.0	COG1309@1|root,COG1309@2|Bacteria,46X7B@74201|Verrucomicrobia,2IUUJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS2_k127_4394562_1	1125863.JAFN01000001_gene913	5.682e-37	153.0	COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,42NTH@68525|delta/epsilon subdivisions,2WJ8N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS2_k127_4394562_0	469381.Dpep_0659	1.342e-47	189.0	COG1538@1|root,COG1538@2|Bacteria,3TAXQ@508458|Synergistetes	508458|Synergistetes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_4394562_2	76114.ebA7103	1.09e-33	143.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2VKCK@28216|Betaproteobacteria,2KVQF@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
CMS2_k127_4420293_1	622637.KE124774_gene1757	2.946e-26	109.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2TSV8@28211|Alphaproteobacteria,36XSY@31993|Methylocystaceae	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	feuP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_4420293_2	118168.MC7420_5234	2.93e-13	82.0	COG5563@1|root,COG5563@2|Bacteria,1GIA8@1117|Cyanobacteria,1HFHC@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4420293_0	994573.T472_0215450	6.633e-188	634.0	29DE2@1|root,300BX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4420293_4	314287.GB2207_07208	8.286e-12	80.0	COG5276@1|root,COG5276@2|Bacteria,1R8AF@1224|Proteobacteria,1S8X1@1236|Gammaproteobacteria,1JC20@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4443223_7	497965.Cyan7822_5141	4.671e-83	294.0	COG0457@1|root,COG1672@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,1G1QI@1117|Cyanobacteria,3KHNA@43988|Cyanothece	1117|Cyanobacteria	K	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,TPR_10,TPR_12,TPR_7,TPR_8
CMS2_k127_4443223_3	575540.Isop_2659	3.24e-195	621.0	COG0516@1|root,COG0516@2|Bacteria,2IX43@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
CMS2_k127_4443223_2	247490.KSU1_C1316	3.036e-216	685.0	COG0519@1|root,COG0519@2|Bacteria,2IX19@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
CMS2_k127_4443223_10	526227.Mesil_0618	1.056e-27	119.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	HEPN,NTP_transf_2
CMS2_k127_4443223_1	485913.Krac_9382	9.32e-274	862.0	COG1505@1|root,COG1505@2|Bacteria,2GBNH@200795|Chloroflexi	200795|Chloroflexi	E	Peptidase S9, prolyl oligopeptidase active site domain protein	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
CMS2_k127_4443223_9	1382306.JNIM01000001_gene171	5.757e-34	142.0	COG2362@1|root,COG2362@2|Bacteria,2G8M4@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M55 D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
CMS2_k127_4443223_11	46234.ANA_C13788	4.26e-24	119.0	COG1404@1|root,COG2911@1|root,COG2931@1|root,COG3291@1|root,COG3537@1|root,COG1404@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,COG3537@2|Bacteria,1G2N0@1117|Cyanobacteria,1HRSX@1161|Nostocales	1117|Cyanobacteria	GOQ	Calx-beta domain	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Calx-beta,DUF4114,DUF4347,HemolysinCabind,Laminin_G_3,SBP_bac_3,VCBS
CMS2_k127_4443223_4	945713.IALB_1186	9.107e-177	579.0	COG5368@1|root,COG5368@2|Bacteria	2|Bacteria	S	Putative glucoamylase	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF3131,Glycoamylase
CMS2_k127_4443223_5	575540.Isop_3355	1.449e-160	524.0	COG1028@1|root,COG1028@2|Bacteria,2J42Z@203682|Planctomycetes	203682|Planctomycetes	IQ	Short-chain dehydrogenase reductase Sdr	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4443223_0	395961.Cyan7425_5008	1.586e-304	983.0	COG0553@1|root,COG0553@2|Bacteria,1G2YQ@1117|Cyanobacteria,3KJJS@43988|Cyanothece	1117|Cyanobacteria	KL	COG0553 Superfamily II DNA RNA helicases, SNF2 family	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
CMS2_k127_4443223_6	886293.Sinac_6469	8.746e-160	516.0	COG0436@1|root,COG0436@2|Bacteria,2IY66@203682|Planctomycetes	203682|Planctomycetes	E	aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_4443223_8	517418.Ctha_1865	3.625e-59	222.0	COG5184@1|root,COG5492@1|root,COG5184@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,CHU_C,Calx-beta,ChW,Flg_new,Glug,Phage_TTP_12,RCC1
CMS2_k127_4475861_3	1267535.KB906767_gene934	3.283e-57	226.0	COG3292@1|root,COG3292@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1906,VCBS
CMS2_k127_4475861_2	886293.Sinac_1631	1.921e-61	240.0	COG3064@1|root,COG3064@2|Bacteria,2IYZ5@203682|Planctomycetes	203682|Planctomycetes	M	SpoIVB peptidase S55	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S55
CMS2_k127_4475861_1	247490.KSU1_D0086	9.247e-84	288.0	COG0564@1|root,COG0564@2|Bacteria,2IXSI@203682|Planctomycetes	203682|Planctomycetes	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS2_k127_4475861_4	1191523.MROS_1195	1.922e-44	179.0	COG0569@1|root,COG0569@2|Bacteria	2|Bacteria	P	domain protein	ktrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS2_k127_4475861_0	880073.Calab_0113	1.817e-102	354.0	COG0168@1|root,COG0168@2|Bacteria,2NNW1@2323|unclassified Bacteria	2|Bacteria	P	Cation transport protein	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS2_k127_4520674_4	1289387.AUKW01000011_gene749	3.923e-55	211.0	COG0591@1|root,COG0591@2|Bacteria,2GKPW@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_4520674_11	765177.Desmu_1208	1.585e-10	72.0	COG0441@1|root,arCOG00401@2157|Archaea,2XQ02@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr)	thrS	GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
CMS2_k127_4520674_13	1121912.AUHD01000005_gene1574	7.398e-05	52.0	COG1595@1|root,COG1595@2|Bacteria,4NSDS@976|Bacteroidetes,1IIVX@117743|Flavobacteriia	976|Bacteroidetes	K	Bacterial regulatory proteins, luxR family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_4520674_12	1123242.JH636434_gene5447	3.416e-05	58.0	COG4783@1|root,COG4783@2|Bacteria,2J20S@203682|Planctomycetes	203682|Planctomycetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
CMS2_k127_4520674_6	1125863.JAFN01000001_gene2299	2.95e-48	181.0	COG2344@1|root,COG2344@2|Bacteria,1R55V@1224|Proteobacteria,42M2S@68525|delta/epsilon subdivisions,2WM6N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
CMS2_k127_4520674_3	519442.Huta_2602	1.516e-73	260.0	COG1145@1|root,arCOG05128@2157|Archaea,2XY2U@28890|Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S dicluster domain	-	-	1.12.98.4	ko:K17996	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	Fer4_22
CMS2_k127_4520674_1	237368.SCABRO_02489	2.907e-90	304.0	COG0543@1|root,COG0543@2|Bacteria,2IYBB@203682|Planctomycetes	203682|Planctomycetes	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
CMS2_k127_4520674_2	237368.SCABRO_02488	1.943e-77	271.0	COG1941@1|root,COG1941@2|Bacteria,2IXWB@203682|Planctomycetes	203682|Planctomycetes	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
CMS2_k127_4520674_0	880073.Calab_0420	6.423e-135	443.0	COG3259@1|root,COG3259@2|Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	hoxH	-	1.12.1.2,1.8.98.5	ko:K00436,ko:K14126	ko00680,map00680	-	R00019,R00700,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
CMS2_k127_4520674_10	795359.TOPB45_0466	1.651e-24	109.0	COG0680@1|root,COG0680@2|Bacteria,2GHZS@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
CMS2_k127_4520674_9	880073.Calab_0422	5.979e-29	123.0	COG0745@1|root,COG0745@2|Bacteria,2NRCE@2323|unclassified Bacteria	2|Bacteria	KT	cheY-homologous receiver domain	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
CMS2_k127_4520674_8	1449126.JQKL01000018_gene3279	5.017e-36	153.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,268VW@186813|unclassified Clostridiales	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_9,Response_reg,sCache_3_3
CMS2_k127_4520674_7	1869.MB27_39815	1.181e-46	175.0	COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria,4D9TJ@85008|Micromonosporales	201174|Actinobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
CMS2_k127_4520674_5	521045.Kole_0574	4.556e-55	206.0	COG0479@1|root,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
CMS2_k127_4528834_6	1226322.HMPREF1545_00428	8.237e-47	173.0	COG1670@1|root,COG1670@2|Bacteria,1V5V9@1239|Firmicutes,24FVA@186801|Clostridia,2N7NZ@216572|Oscillospiraceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
CMS2_k127_4528834_10	1192034.CAP_8035	6.417e-30	135.0	2EIT9@1|root,33CIJ@2|Bacteria,1Q2I7@1224|Proteobacteria,43851@68525|delta/epsilon subdivisions,2X3F1@28221|Deltaproteobacteria,2YVSV@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4528834_8	1540257.JQMW01000009_gene3132	5.539e-38	146.0	COG1051@1|root,COG1051@2|Bacteria,1V3MM@1239|Firmicutes,24I7G@186801|Clostridia,36K3A@31979|Clostridiaceae	186801|Clostridia	F	NUDIX domain	-	-	-	ko:K12944	-	-	-	-	ko00000,ko01000	-	-	-	NUDIX
CMS2_k127_4528834_4	1499967.BAYZ01000088_gene5065	3.756e-62	221.0	COG2365@1|root,COG2365@2|Bacteria	2|Bacteria	T	protein tyrosine phosphatase activity	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	DSPc,Y_phosphatase2,Y_phosphatase3
CMS2_k127_4528834_3	237368.SCABRO_04024	2.3e-62	226.0	COG2006@1|root,COG2006@2|Bacteria,2J1TZ@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS2_k127_4528834_0	1173021.ALWA01000012_gene1277	5.36e-131	429.0	COG0436@1|root,COG0436@2|Bacteria,1G0M8@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Aminotransferase class I and II	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_4528834_16	1123242.JH636434_gene5370	1.808e-06	58.0	COG2165@1|root,COG2165@2|Bacteria,2IXC8@203682|Planctomycetes	203682|Planctomycetes	NU	TIGRFAM prepilin-type N-terminal cleavage methylation domain	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_4528834_11	935839.JAGJ01000029_gene22	2.044e-24	121.0	COG0810@1|root,COG3055@1|root,COG0810@2|Bacteria,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	3.2.1.4	ko:K01179,ko:K03832	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko02000	2.C.1.1	GH5,GH9	-	Malectin,NPCBM,Sigma70_r2
CMS2_k127_4528834_15	459349.CLOAM0895	1.773e-08	68.0	COG1361@1|root,COG1404@1|root,COG4412@1|root,COG1361@2|Bacteria,COG1404@2|Bacteria,COG4412@2|Bacteria,2NREM@2323|unclassified Bacteria	2|Bacteria	O	Evidence 5 No homology to any previously reported sequences	-	-	3.4.17.22	ko:K07752	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Calx-beta,DUF4859,FlgD_ig,VCBS
CMS2_k127_4528834_13	1122927.KB895431_gene78	1.126e-09	72.0	COG0383@1|root,COG2120@1|root,COG3210@1|root,COG4099@1|root,COG4733@1|root,COG5184@1|root,COG5276@1|root,COG0383@2|Bacteria,COG2120@2|Bacteria,COG3210@2|Bacteria,COG4099@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	3.2.1.24,3.4.24.40	ko:K01191,ko:K01406,ko:K20276	ko00511,ko01503,ko02024,map00511,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04131	-	GH38	-	Big_2,Cohesin,F5_F8_type_C,PIG-L,RCC1_2
CMS2_k127_4528834_7	1122925.KB895385_gene3064	6.405e-44	185.0	COG3507@1|root,COG3533@1|root,COG3507@2|Bacteria,COG3533@2|Bacteria,1U157@1239|Firmicutes,4HT9T@91061|Bacilli,26UV2@186822|Paenibacillaceae	91061|Bacilli	G	Concanavalin A-like lectin/glucanases superfamily	M1-853	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS2_k127_4528834_5	1051646.VITU9109_14061	1.017e-59	222.0	COG0265@1|root,COG3291@1|root,COG0265@2|Bacteria,COG3291@2|Bacteria,1R6VW@1224|Proteobacteria,1SNEA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4528834_1	1051646.VITU9109_14061	2.641e-71	257.0	COG0265@1|root,COG3291@1|root,COG0265@2|Bacteria,COG3291@2|Bacteria,1R6VW@1224|Proteobacteria,1SNEA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4528834_2	1051646.VITU9109_14061	1.447e-63	235.0	COG0265@1|root,COG3291@1|root,COG0265@2|Bacteria,COG3291@2|Bacteria,1R6VW@1224|Proteobacteria,1SNEA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4528834_9	1317122.ATO12_12685	9.304e-35	149.0	COG2730@1|root,COG3250@1|root,COG4733@1|root,COG2730@2|Bacteria,COG3250@2|Bacteria,COG4733@2|Bacteria,4NIBG@976|Bacteroidetes,1HYT8@117743|Flavobacteriia,2YJTE@290174|Aquimarina	976|Bacteroidetes	G	Cellulase (glycosyl hydrolase family 5)	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_6,Cellulase,F5_F8_type_C,fn3
CMS2_k127_4529033_3	1305737.JAFX01000001_gene3155	3.874e-36	139.0	COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,47UAQ@768503|Cytophagia	976|Bacteroidetes	P	Sodium/calcium exchanger protein	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS2_k127_4529033_4	247490.KSU1_A0021	9.911e-35	154.0	COG2928@1|root,COG2928@2|Bacteria,2J0RM@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
CMS2_k127_4529033_5	446462.Amir_0185	8.986e-21	109.0	COG1262@1|root,COG2944@1|root,COG1262@2|Bacteria,COG2944@2|Bacteria,2GK9Q@201174|Actinobacteria,4E1IA@85010|Pseudonocardiales	201174|Actinobacteria	K	Sulfatase-modifying factor enzyme 1	-	-	-	ko:K20333	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	FGE-sulfatase,HTH_31
CMS2_k127_4529033_2	590998.Celf_0345	1.564e-52	212.0	COG3507@1|root,COG5297@1|root,COG3507@2|Bacteria,COG5297@2|Bacteria,2I363@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 28 family	yesW	-	-	-	-	-	-	-	-	-	-	-	CBM_2
CMS2_k127_4529033_1	452637.Oter_0021	4.05e-133	455.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS2_k127_4529033_0	1267535.KB906767_gene3131	2.948e-162	540.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria,2JI3C@204432|Acidobacteriia	204432|Acidobacteriia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS2_k127_4532054_9	1089550.ATTH01000001_gene1100	6.949e-05	48.0	COG1319@1|root,COG3210@1|root,COG3386@1|root,COG4412@1|root,COG4733@1|root,COG1319@2|Bacteria,COG3210@2|Bacteria,COG3386@2|Bacteria,COG4412@2|Bacteria,COG4733@2|Bacteria,4PEZ5@976|Bacteroidetes,1FJW1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	U	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,Laminin_G_3
CMS2_k127_4532054_1	1120950.KB892759_gene6279	5.18e-90	311.0	COG0836@1|root,COG0836@2|Bacteria,2GIRM@201174|Actinobacteria,4DPTJ@85009|Propionibacteriales	201174|Actinobacteria	M	Nucleotidyl transferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
CMS2_k127_4532054_5	1121440.AUMA01000007_gene1170	1.389e-30	125.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,42UC6@68525|delta/epsilon subdivisions,2WPDD@28221|Deltaproteobacteria,2MBU6@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
CMS2_k127_4532054_4	936375.HMPREF1152_0388	1.626e-31	125.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,3WCM8@538999|Clostridiales incertae sedis	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
CMS2_k127_4532054_0	671143.DAMO_0581	7.593e-221	708.0	COG1185@1|root,COG1185@2|Bacteria,2NNX7@2323|unclassified Bacteria	2|Bacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
CMS2_k127_4532054_2	237368.SCABRO_02976	8.702e-48	184.0	COG5000@1|root,COG5000@2|Bacteria,2IZCJ@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS2_k127_4532054_8	27923.ML03352a-PA	3.994e-05	54.0	COG0457@1|root,KOG1124@2759|Eukaryota,38D6F@33154|Opisthokonta,3BACP@33208|Metazoa	33208|Metazoa	S	dynactin binding	BBS4	GO:0000003,GO:0000226,GO:0000242,GO:0000278,GO:0000281,GO:0000910,GO:0001085,GO:0001103,GO:0001654,GO:0001750,GO:0001754,GO:0001764,GO:0001838,GO:0001841,GO:0001843,GO:0001894,GO:0001895,GO:0001917,GO:0001947,GO:0002009,GO:0003006,GO:0003007,GO:0003008,GO:0003013,GO:0003073,GO:0003085,GO:0003143,GO:0003352,GO:0003356,GO:0003674,GO:0003774,GO:0003777,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005813,GO:0005814,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0006810,GO:0006928,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007098,GO:0007154,GO:0007165,GO:0007166,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007286,GO:0007368,GO:0007389,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0007507,GO:0007600,GO:0007606,GO:0007608,GO:0007610,GO:0008015,GO:0008064,GO:0008092,GO:0008104,GO:0008134,GO:0008150,GO:0008217,GO:0009605,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009799,GO:0009855,GO:0009887,GO:0009888,GO:0009892,GO:0009987,GO:0009991,GO:0010033,GO:0010468,GO:0010564,GO:0010605,GO:0010629,GO:0010638,GO:0010639,GO:0014020,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016331,GO:0016358,GO:0016462,GO:0016477,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019216,GO:0019221,GO:0019222,GO:0019953,GO:0021537,GO:0021543,GO:0021544,GO:0021591,GO:0021756,GO:0021761,GO:0021766,GO:0021915,GO:0021987,GO:0022008,GO:0022402,GO:0022412,GO:0022414,GO:0022607,GO:0023052,GO:0030030,GO:0030031,GO:0030154,GO:0030182,GO:0030534,GO:0030832,GO:0030833,GO:0030837,GO:0030900,GO:0031023,GO:0031090,GO:0031175,GO:0031253,GO:0031333,GO:0031344,GO:0031346,GO:0031514,GO:0031667,GO:0032095,GO:0032096,GO:0032098,GO:0032099,GO:0032101,GO:0032102,GO:0032104,GO:0032105,GO:0032107,GO:0032108,GO:0032231,GO:0032271,GO:0032272,GO:0032391,GO:0032400,GO:0032401,GO:0032402,GO:0032465,GO:0032501,GO:0032502,GO:0032504,GO:0032507,GO:0032535,GO:0032870,GO:0032879,GO:0032886,GO:0032956,GO:0032970,GO:0032991,GO:0033036,GO:0033043,GO:0033059,GO:0033210,GO:0033365,GO:0034097,GO:0034260,GO:0034451,GO:0034452,GO:0034453,GO:0034454,GO:0034464,GO:0034504,GO:0034613,GO:0035050,GO:0035148,GO:0035176,GO:0035239,GO:0035295,GO:0035845,GO:0035869,GO:0036064,GO:0038108,GO:0040008,GO:0040011,GO:0040012,GO:0040014,GO:0040018,GO:0042221,GO:0042461,GO:0042462,GO:0042592,GO:0042995,GO:0043005,GO:0043009,GO:0043014,GO:0043086,GO:0043087,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0043473,GO:0044085,GO:0044087,GO:0044089,GO:0044092,GO:0044320,GO:0044321,GO:0044380,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044450,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044782,GO:0045185,GO:0045444,GO:0045494,GO:0045724,GO:0045776,GO:0045927,GO:0046530,GO:0046548,GO:0046907,GO:0048232,GO:0048468,GO:0048487,GO:0048513,GO:0048515,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048562,GO:0048568,GO:0048583,GO:0048585,GO:0048592,GO:0048598,GO:0048609,GO:0048638,GO:0048639,GO:0048646,GO:0048666,GO:0048699,GO:0048729,GO:0048731,GO:0048854,GO:0048856,GO:0048869,GO:0048870,GO:0048871,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050877,GO:0050890,GO:0050893,GO:0050896,GO:0051094,GO:0051128,GO:0051129,GO:0051130,GO:0051179,GO:0051234,GO:0051235,GO:0051239,GO:0051240,GO:0051270,GO:0051301,GO:0051302,GO:0051336,GO:0051346,GO:0051457,GO:0051492,GO:0051493,GO:0051494,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051651,GO:0051656,GO:0051674,GO:0051703,GO:0051704,GO:0051705,GO:0051716,GO:0051726,GO:0051875,GO:0051904,GO:0051905,GO:0060170,GO:0060249,GO:0060255,GO:0060271,GO:0060295,GO:0060296,GO:0060322,GO:0060324,GO:0060429,GO:0060491,GO:0060562,GO:0060606,GO:0060612,GO:0060613,GO:0060632,GO:0061371,GO:0061448,GO:0061512,GO:0061640,GO:0065007,GO:0065008,GO:0065009,GO:0070491,GO:0070727,GO:0070887,GO:0070925,GO:0071310,GO:0071345,GO:0071495,GO:0071539,GO:0071840,GO:0071944,GO:0072175,GO:0072359,GO:0072393,GO:0072595,GO:0072698,GO:0080090,GO:0090066,GO:0090596,GO:0097458,GO:0097499,GO:0097730,GO:0097731,GO:0097733,GO:0098588,GO:0098590,GO:0110020,GO:0110053,GO:0120025,GO:0120031,GO:0120032,GO:0120034,GO:0120035,GO:0120036,GO:0120038,GO:1902017,GO:1902019,GO:1902115,GO:1902117,GO:1902855,GO:1902903,GO:1902904,GO:1903047,GO:1903546,GO:1905508,GO:1905515,GO:2000145	-	ko:K16531	-	-	-	-	ko00000,ko03036	-	-	-	TPR_16,TPR_2,TPR_8
CMS2_k127_4532054_3	688245.CtCNB1_2093	3.667e-40	161.0	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2VIA4@28216|Betaproteobacteria,4ADRI@80864|Comamonadaceae	28216|Betaproteobacteria	NU	type II secretion system protein	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
CMS2_k127_4532054_6	404380.Gbem_1054	9.302e-29	128.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,42QS0@68525|delta/epsilon subdivisions,2WMU6@28221|Deltaproteobacteria,43SJM@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
CMS2_k127_4532054_7	1210884.HG799462_gene8909	6.15e-16	80.0	COG4962@1|root,COG4962@2|Bacteria,2IXAQ@203682|Planctomycetes	203682|Planctomycetes	U	Secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
CMS2_k127_4537277_6	1536770.R50345_05345	2.465e-06	49.0	2DBT1@1|root,2ZAV2@2|Bacteria,1UNU0@1239|Firmicutes,4HV6J@91061|Bacilli,277PR@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4537277_3	522306.CAP2UW1_2667	3.191e-115	384.0	28HTA@1|root,2Z806@2|Bacteria,1R7QM@1224|Proteobacteria,2W2CU@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4537277_1	886293.Sinac_2331	7.398e-119	396.0	COG0743@1|root,COG0743@2|Bacteria,2IY3M@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
CMS2_k127_4537277_5	1142394.PSMK_24590	5.785e-64	244.0	COG0265@1|root,COG0750@1|root,COG0265@2|Bacteria,COG0750@2|Bacteria,2IXWE@203682|Planctomycetes	203682|Planctomycetes	M	PDZ domain (Also known as DHR	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
CMS2_k127_4537277_4	1128421.JAGA01000003_gene3189	3.425e-115	387.0	COG0112@1|root,COG0112@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	iG2583_1286.G2583_3081,iIT341.HP0183	SHMT
CMS2_k127_4537277_2	1303518.CCALI_00390	2.056e-117	386.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS2_k127_4537277_0	530564.Psta_4031	3.587e-132	440.0	COG0015@1|root,COG0015@2|Bacteria,2IXU4@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
CMS2_k127_454873_1	1304885.AUEY01000061_gene2832	7.317e-29	136.0	COG3420@1|root,COG3420@2|Bacteria,1MZHI@1224|Proteobacteria,43BRC@68525|delta/epsilon subdivisions,2WUM4@28221|Deltaproteobacteria,2MN6K@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_454873_0	443143.GM18_4316	6.632e-80	302.0	COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,1MU3S@1224|Proteobacteria,42Q3Z@68525|delta/epsilon subdivisions,2WJPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the peptidase S8 family	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Big_2,CUB,He_PIG,Peptidase_S8
CMS2_k127_4551288_3	1499967.BAYZ01000048_gene2698	4.805e-51	184.0	COG2907@1|root,COG2907@2|Bacteria,2NS11@2323|unclassified Bacteria	2|Bacteria	S	Flavin containing amine oxidoreductase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
CMS2_k127_4551288_1	1499967.BAYZ01000048_gene2699	7.967e-125	408.0	COG1398@1|root,COG1398@2|Bacteria	2|Bacteria	I	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	desC	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
CMS2_k127_4551288_0	472759.Nhal_3536	4.345e-196	636.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1WXGJ@135613|Chromatiales	1236|Gammaproteobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
CMS2_k127_4551288_5	237368.SCABRO_02097	1.383e-38	149.0	COG0748@1|root,COG0748@2|Bacteria	2|Bacteria	P	coenzyme F420 binding	-	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Putative_PNPOx
CMS2_k127_4551288_2	706587.Desti_1456	5.506e-62	221.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	prx-4	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
CMS2_k127_4551288_4	1123508.JH636441_gene3779	2.311e-46	185.0	COG0627@1|root,COG0627@2|Bacteria	2|Bacteria	J	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,Hepar_II_III
CMS2_k127_4554941_13	697329.Rumal_1266	1.755e-06	60.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,3WH50@541000|Ruminococcaceae	186801|Clostridia	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS2_k127_4554941_7	1114959.SZMC14600_17839	1.45e-27	120.0	COG0350@1|root,COG0350@2|Bacteria,2GKA9@201174|Actinobacteria,4EEP5@85010|Pseudonocardiales	201174|Actinobacteria	L	PFAM 6-O-methylguanine DNA methyltransferase, DNA binding domain	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
CMS2_k127_4554941_0	1142394.PSMK_11990	1.752e-120	396.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,2IWZ7@203682|Planctomycetes	203682|Planctomycetes	E	chorismate mutase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
CMS2_k127_4554941_1	1191523.MROS_1843	5.041e-81	277.0	COG0149@1|root,COG0149@2|Bacteria	2|Bacteria	G	triose-phosphate isomerase activity	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
CMS2_k127_4554941_12	575540.Isop_1880	6.478e-09	62.0	COG1314@1|root,COG1314@2|Bacteria,2J0NU@203682|Planctomycetes	203682|Planctomycetes	U	PFAM Preprotein translocase SecG subunit	-	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
CMS2_k127_4554941_2	530564.Psta_3126	1.994e-57	211.0	COG1561@1|root,COG1561@2|Bacteria,2IYZH@203682|Planctomycetes	203682|Planctomycetes	S	stress-induced protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
CMS2_k127_4554941_3	118163.Ple7327_1201	8.171e-48	179.0	COG0194@1|root,COG0194@2|Bacteria,1G515@1117|Cyanobacteria,3VJPD@52604|Pleurocapsales	1117|Cyanobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
CMS2_k127_4554941_9	1123242.JH636434_gene5388	2.064e-15	80.0	COG1758@1|root,COG1758@2|Bacteria,2J0KS@203682|Planctomycetes	203682|Planctomycetes	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
CMS2_k127_4554941_4	84531.JMTZ01000018_gene3931	9.136e-48	177.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1X3EH@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
CMS2_k127_4554941_10	794903.OPIT5_20185	2.973e-14	83.0	COG2165@1|root,COG2165@2|Bacteria,46WQM@74201|Verrucomicrobia,3K9N5@414999|Opitutae	414999|Opitutae	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS2_k127_4554941_5	760568.Desku_1307	6.442e-45	171.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,25ZXR@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
CMS2_k127_4554941_11	1125863.JAFN01000001_gene878	7.852e-12	74.0	COG0620@1|root,COG0620@2|Bacteria,1R6KI@1224|Proteobacteria,42PCN@68525|delta/epsilon subdivisions,2WKT3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4554941_8	1123242.JH636435_gene2923	1.084e-22	112.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	fecI	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_4554941_6	1210884.HG799463_gene9711	1.906e-44	165.0	COG4249@1|root,COG4249@2|Bacteria,2IZ2A@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4559603_9	706587.Desti_1030	1.483e-29	121.0	COG1309@1|root,COG1309@2|Bacteria,1RGQQ@1224|Proteobacteria	1224|Proteobacteria	K	tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS2_k127_4559603_6	382464.ABSI01000010_gene3740	3.664e-33	132.0	COG1725@1|root,COG1725@2|Bacteria	2|Bacteria	K	Transcriptional regulator	ytrA	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS2_k127_4559603_0	382464.ABSI01000010_gene3739	2.73e-103	345.0	COG0330@1|root,COG0330@2|Bacteria,46VDU@74201|Verrucomicrobia	74201|Verrucomicrobia	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS2_k127_4559603_2	246196.MSMEI_6705	1.366e-65	245.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria	201174|Actinobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS2_k127_4559603_8	484770.UFO1_1221	1.386e-29	135.0	COG3324@1|root,COG3324@2|Bacteria,1VIFA@1239|Firmicutes,4H7FK@909932|Negativicutes	909932|Negativicutes	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
CMS2_k127_4559603_5	1111728.ATYS01000041_gene2538	8.597e-42	155.0	COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1S62I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the UPF0145 family	ybjQ	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
CMS2_k127_4559603_3	631362.Thi970DRAFT_01557	2.058e-61	243.0	COG2197@1|root,COG2199@1|root,COG2202@1|root,COG4585@1|root,COG2197@2|Bacteria,COG2202@2|Bacteria,COG3706@2|Bacteria,COG4585@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,HATPase_c,HWE_HK,HisKA,MASE1,PAS,PAS_3,PAS_4,PAS_9,Reg_prop,Response_reg,Y_Y_Y,dCache_1
CMS2_k127_4559603_7	595460.RRSWK_00480	6.276e-31	143.0	COG0642@1|root,COG0745@1|root,COG1352@1|root,COG2201@1|root,COG3829@1|root,COG5002@1|root,COG0745@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,2IWSR@203682|Planctomycetes	203682|Planctomycetes	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,Response_reg
CMS2_k127_4559603_1	247490.KSU1_D0867	9.273e-101	370.0	COG2203@1|root,COG3829@1|root,COG4251@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,2J2DQ@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,dCache_1
CMS2_k127_4559603_10	44060.JODL01000001_gene3071	3.662e-17	87.0	COG2197@1|root,COG2197@2|Bacteria,2GN3A@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	chiR	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS2_k127_4559603_4	756272.Plabr_1542	1.535e-59	210.0	COG0590@1|root,COG0590@2|Bacteria,2IZCA@203682|Planctomycetes	203682|Planctomycetes	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
CMS2_k127_4559603_11	580340.Tlie_1588	0.0006068	47.0	28XQZ@1|root,2ZJMK@2|Bacteria,3TCGY@508458|Synergistetes	508458|Synergistetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4566053_3	158190.SpiGrapes_0285	1.56e-21	109.0	COG1902@1|root,COG1902@2|Bacteria	2|Bacteria	C	pentaerythritol trinitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red,Oxidored_FMN
CMS2_k127_4566053_2	1458462.JNLK01000001_gene761	5.914e-77	277.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,27REU@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
CMS2_k127_4566053_1	794903.OPIT5_16130	3.738e-83	284.0	COG1028@1|root,COG1028@2|Bacteria,46TD2@74201|Verrucomicrobia,3K7W5@414999|Opitutae	414999|Opitutae	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS2_k127_4566053_4	1045855.DSC_07850	1.14e-16	90.0	COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,1RPDF@1236|Gammaproteobacteria,1X4EU@135614|Xanthomonadales	135614|Xanthomonadales	G	Aldolase	eda	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
CMS2_k127_4566053_0	243090.RB940	3.974e-133	432.0	COG3386@1|root,COG3386@2|Bacteria,2J2MK@203682|Planctomycetes	203682|Planctomycetes	G	BNR repeat-containing family member	-	-	-	-	-	-	-	-	-	-	-	-	BNR_4
CMS2_k127_4566736_8	247490.KSU1_D0541	4.816e-19	92.0	2EDD9@1|root,3379K@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3568)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3568
CMS2_k127_4566736_5	497964.CfE428DRAFT_5517	1.03e-28	126.0	COG1262@1|root,COG1262@2|Bacteria,46VAM@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,VPEP
CMS2_k127_4566736_11	497964.CfE428DRAFT_2146	1.47e-12	80.0	COG1262@1|root,COG1262@2|Bacteria,46VAM@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,VPEP
CMS2_k127_4566736_3	935845.JADQ01000029_gene1230	4.75e-67	246.0	COG2755@1|root,COG4257@1|root,COG5184@1|root,COG2755@2|Bacteria,COG4257@2|Bacteria,COG5184@2|Bacteria,1UZD4@1239|Firmicutes,4HD48@91061|Bacilli,26VBQ@186822|Paenibacillaceae	91061|Bacilli	DZ	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like,RCC1_2,SLH
CMS2_k127_4566736_9	469618.FVAG_00037	3.409e-18	90.0	29IC7@1|root,3059E@2|Bacteria,37AAR@32066|Fusobacteria	32066|Fusobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4566736_1	945713.IALB_2433	3.081e-119	396.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	DUF3318,Peptidase_M48
CMS2_k127_4566736_2	945713.IALB_2434	2.571e-67	234.0	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
CMS2_k127_4566736_0	700598.Niako_0563	1.048e-133	436.0	COG4409@1|root,COG4409@2|Bacteria,4NFNK@976|Bacteroidetes,1IRAJ@117747|Sphingobacteriia	976|Bacteroidetes	G	BNR repeat-like domain	-	-	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2
CMS2_k127_4566736_6	945713.IALB_2435	1.473e-26	116.0	COG3809@1|root,COG3809@2|Bacteria	2|Bacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-TFIIB
CMS2_k127_4566736_4	1142394.PSMK_31090	9.02e-45	174.0	COG2159@1|root,COG2159@2|Bacteria,2IXTD@203682|Planctomycetes	203682|Planctomycetes	S	TIM-barrel fold	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
CMS2_k127_4566736_7	186497.PF0510	4.948e-22	98.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ0S@28890|Euryarchaeota,244B1@183968|Thermococci	183968|Thermococci	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
CMS2_k127_4566736_10	338966.Ppro_2732	5.999e-16	83.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,42V63@68525|delta/epsilon subdivisions,2WQCH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	TIGRFAM transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS2_k127_4567896_3	768671.ThimaDRAFT_2989	1.641e-25	108.0	2ED63@1|root,3372T@2|Bacteria,1NEJK@1224|Proteobacteria,1SD1X@1236|Gammaproteobacteria,1WZG9@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4567896_0	237368.SCABRO_01933	1.118e-168	545.0	COG0034@1|root,COG0034@2|Bacteria,2IXKC@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
CMS2_k127_4567896_1	1142394.PSMK_01400	2.497e-123	405.0	COG0150@1|root,COG0150@2|Bacteria,2IYCG@203682|Planctomycetes	203682|Planctomycetes	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
CMS2_k127_4567896_2	765912.Thimo_2707	1.385e-91	306.0	COG0500@1|root,COG2226@2|Bacteria,1RF5Y@1224|Proteobacteria,1S57V@1236|Gammaproteobacteria,1X0H8@135613|Chromatiales	135613|Chromatiales	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_456937_4	221288.JH992901_gene2820	3.846e-52	187.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	-	-	-	ko:K03825	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
CMS2_k127_456937_3	1282362.AEAC466_10935	4.722e-74	264.0	COG3693@1|root,COG3693@2|Bacteria,1R8V3@1224|Proteobacteria	1224|Proteobacteria	G	Glycosyl hydrolase family 62	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_62
CMS2_k127_456937_5	768706.Desor_2741	2.032e-40	157.0	COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,24MUB@186801|Clostridia,2657X@186807|Peptococcaceae	186801|Clostridia	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
CMS2_k127_456937_0	237368.SCABRO_00554	1.357e-106	357.0	COG0533@1|root,COG0533@2|Bacteria,2IXJP@203682|Planctomycetes	203682|Planctomycetes	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CMS2_k127_456937_1	555088.DealDRAFT_1696	5.836e-89	301.0	COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,42KEE@68298|Syntrophomonadaceae	186801|Clostridia	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
CMS2_k127_456937_2	1123508.JH636441_gene3274	2.523e-74	259.0	COG0063@1|root,COG0063@2|Bacteria,2IYWH@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase
CMS2_k127_458627_17	1157490.EL26_03800	3.018e-11	65.0	COG1164@1|root,COG1164@2|Bacteria,1U8XY@1239|Firmicutes,4HEV8@91061|Bacilli	91061|Bacilli	E	Peptidase M3A and M3B thimet oligopeptidase F	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M2,Peptidase_M3
CMS2_k127_458627_5	1267535.KB906767_gene2245	5.414e-89	310.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	putP_2	-	-	ko:K03307,ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21,2.A.21.2	-	-	SSF
CMS2_k127_458627_2	1191523.MROS_0680	6.427e-153	501.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	pepQ	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
CMS2_k127_458627_14	641143.HMPREF9331_01691	4.387e-26	114.0	COG3118@1|root,COG3118@2|Bacteria,4NQ5B@976|Bacteroidetes,1I2SS@117743|Flavobacteriia,1ERZM@1016|Capnocytophaga	976|Bacteroidetes	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS2_k127_458627_18	945713.IALB_2366	2.5e-06	55.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
CMS2_k127_458627_1	448385.sce4660	3.173e-165	533.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,43BMH@68525|delta/epsilon subdivisions,2X6ZP@28221|Deltaproteobacteria,2Z3JZ@29|Myxococcales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS2_k127_458627_16	1303518.CCALI_00340	3.405e-14	83.0	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_458627_4	1210884.HG799465_gene12146	8.828e-137	447.0	COG1520@1|root,COG1520@2|Bacteria,2J2YU@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_458627_8	443143.GM18_0452	2.064e-55	197.0	COG5015@1|root,COG5015@2|Bacteria	2|Bacteria	K	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS2_k127_458627_6	443143.GM18_0452	8.236e-67	229.0	COG5015@1|root,COG5015@2|Bacteria	2|Bacteria	K	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS2_k127_458627_11	404380.Gbem_0440	2.346e-38	147.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	rmaB	-	-	ko:K06075	-	-	-	-	ko00000,ko03000	-	-	-	MarR,MarR_2
CMS2_k127_458627_10	1210884.HG799465_gene12146	2.151e-41	158.0	COG1520@1|root,COG1520@2|Bacteria,2J2YU@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_458627_12	1121015.N789_14060	7.769e-38	151.0	COG3600@1|root,COG3600@2|Bacteria,1N78U@1224|Proteobacteria,1SF6A@1236|Gammaproteobacteria,1XAYX@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF4065)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4065
CMS2_k127_458627_13	357808.RoseRS_3823	3.992e-29	120.0	2E95X@1|root,333EM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_458627_15	755178.Cyan10605_2830	1.436e-16	82.0	COG5428@1|root,COG5428@2|Bacteria,1G9S2@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
CMS2_k127_458627_7	243277.VC_A0396	1.578e-59	212.0	28KAG@1|root,2Z87J@2|Bacteria,1R7H8@1224|Proteobacteria,1S4P4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Abortive infection C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Abi_C
CMS2_k127_458627_3	391625.PPSIR1_16130	4.789e-148	482.0	COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,42Y58@68525|delta/epsilon subdivisions,2WTVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
CMS2_k127_458627_0	583355.Caka_3109	2.728e-207	680.0	COG2312@1|root,COG3507@1|root,COG2312@2|Bacteria,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	1.16.3.3	ko:K22350	-	-	-	-	ko00000,ko01000	-	-	-	Big_2,Big_4,CBM_6,DUF1080,DUF1349,Erythro_esteras,GSDH,Glyco_hydro_43,LTD,Laminin_G_3,PKD,SLH
CMS2_k127_458627_9	1123242.JH636434_gene5302	8.912e-49	188.0	COG1520@1|root,COG1520@2|Bacteria,2IYRB@203682|Planctomycetes	1123242.JH636434_gene5302|-	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4600614_4	743719.PaelaDRAFT_6111	0.0004761	48.0	COG4632@1|root,COG4632@2|Bacteria,1TQBV@1239|Firmicutes,4H9WI@91061|Bacilli,26QFB@186822|Paenibacillaceae	91061|Bacilli	G	copper amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cu_amine_oxidN1,NAGPA,SLH
CMS2_k127_4600614_0	880073.Calab_0031	7.84e-155	499.0	COG2017@1|root,COG2017@2|Bacteria,2NQA5@2323|unclassified Bacteria	2|Bacteria	G	Converts alpha-aldose to the beta-anomer	mro	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
CMS2_k127_4600614_3	318161.Sden_1471	2.913e-14	82.0	293WK@1|root,2ZRBR@2|Bacteria,1PBHQ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4600614_1	1294142.CINTURNW_4358	1.044e-22	109.0	COG2461@1|root,COG2461@2|Bacteria,1TRD5@1239|Firmicutes,24CKX@186801|Clostridia,36GSW@31979|Clostridiaceae	186801|Clostridia	S	Hemerythrin HHE cation binding domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
CMS2_k127_4600614_2	1274524.BSONL12_04374	1.098e-22	108.0	2E2AR@1|root,32XG5@2|Bacteria,1VHHN@1239|Firmicutes	1239|Firmicutes	S	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	AP2,HNH_3
CMS2_k127_4604626_5	886293.Sinac_1624	1.033e-96	325.0	COG0546@1|root,COG0546@2|Bacteria,2IYT6@203682|Planctomycetes	203682|Planctomycetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
CMS2_k127_4604626_4	497964.CfE428DRAFT_0790	1.124e-148	483.0	COG3875@1|root,COG3875@2|Bacteria	2|Bacteria	S	lactate racemase activity	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
CMS2_k127_4604626_7	1502770.JQMG01000001_gene2381	2.687e-38	153.0	COG2931@1|root,COG2931@2|Bacteria,1MY8M@1224|Proteobacteria	1224|Proteobacteria	Q	Belongs to the glycosyl hydrolase family 6	-	-	-	-	-	-	-	-	-	-	-	-	CBM60
CMS2_k127_4604626_8	1123508.JH636442_gene3855	2.873e-12	79.0	2B9HV@1|root,322W0@2|Bacteria,2IZR4@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4604626_0	1191523.MROS_2333	9.941e-239	746.0	COG0362@1|root,COG0362@2|Bacteria	2|Bacteria	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
CMS2_k127_4604626_2	1173027.Mic7113_4331	1.786e-170	542.0	COG0436@1|root,COG0436@2|Bacteria,1G24E@1117|Cyanobacteria,1H6X1@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS2_k127_4604626_6	1173029.JH980292_gene2370	3.702e-77	264.0	COG4948@1|root,COG4948@2|Bacteria,1G57H@1117|Cyanobacteria,1HATA@1150|Oscillatoriales	1117|Cyanobacteria	M	Domain of unknown function (DUF4433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4433
CMS2_k127_4604626_3	1173263.Syn7502_00165	2.436e-149	481.0	COG2110@1|root,COG2110@2|Bacteria,1GEIG@1117|Cyanobacteria,1GZWV@1129|Synechococcus	1117|Cyanobacteria	S	Macro domain	-	-	-	-	-	-	-	-	-	-	-	-	Macro
CMS2_k127_4604626_1	1191523.MROS_2327	1.526e-203	644.0	COG1904@1|root,COG1904@2|Bacteria	2|Bacteria	G	glucuronate isomerase activity	uxaC	GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0042839,GO:0042840,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0071704,GO:0072329,GO:1901575	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO0579,iSbBS512_1146.SbBS512_E3528	UxaC
CMS2_k127_4607826_4	530564.Psta_0402	1.75e-15	84.0	COG1899@1|root,COG1899@2|Bacteria,2IYQN@203682|Planctomycetes	203682|Planctomycetes	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
CMS2_k127_4607826_3	1192034.CAP_3529	5.565e-31	125.0	COG1899@1|root,COG1899@2|Bacteria,1MVC6@1224|Proteobacteria,42QED@68525|delta/epsilon subdivisions,2WJWR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
CMS2_k127_4607826_0	742817.HMPREF9449_02799	3.06e-95	323.0	COG0010@1|root,COG0010@2|Bacteria,4NE01@976|Bacteroidetes,2FSS3@200643|Bacteroidia,22XZG@171551|Porphyromonadaceae	976|Bacteroidetes	E	Arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
CMS2_k127_4607826_1	290512.Paes_0705	3.917e-60	215.0	COG1945@1|root,COG1945@2|Bacteria,1FDKS@1090|Chlorobi	1090|Chlorobi	E	Belongs to the PdaD family	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
CMS2_k127_4607826_2	1499967.BAYZ01000074_gene2175	4.262e-39	149.0	COG4277@1|root,COG4277@2|Bacteria	2|Bacteria	-	-	MA20_15955	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	HHH_3,Radical_SAM
CMS2_k127_4608793_1	1121374.KB891585_gene1992	1.492e-08	64.0	COG1595@1|root,COG1595@2|Bacteria,1N6SV@1224|Proteobacteria,1SEZH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	rNA polymerase sigma factor 70, region 4 type 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_4608793_0	715226.ABI_12910	2.478e-36	142.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2UBV3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,RHS_repeat
CMS2_k127_4620584_3	548479.HMPREF0573_11262	1.056e-24	116.0	2E2AR@1|root,32XG5@2|Bacteria	2|Bacteria	S	PFAM Pathogenesis-related transcriptional factor and ERF	-	-	-	-	-	-	-	-	-	-	-	-	AP2,HNH_3
CMS2_k127_4620584_1	491952.Mar181_2286	1.044e-54	211.0	297A5@1|root,2ZUHQ@2|Bacteria,1MYVB@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4145)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4145
CMS2_k127_4620584_2	1382304.JNIL01000001_gene3197	1.126e-27	130.0	COG0412@1|root,COG0412@2|Bacteria,1UMV9@1239|Firmicutes	1239|Firmicutes	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_7
CMS2_k127_4620584_0	1324957.K933_02151	1.08e-150	497.0	COG3534@1|root,arCOG10185@2157|Archaea,2XVXP@28890|Euryarchaeota,23USN@183963|Halobacteria	1324957.K933_02151|-	G	Alpha-L-arabinofuranosidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_462242_2	1123008.KB905692_gene286	4.386e-118	388.0	COG0477@1|root,COG2814@2|Bacteria,4NE09@976|Bacteroidetes,2FRW6@200643|Bacteroidia	976|Bacteroidetes	U	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	xylE	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
CMS2_k127_462242_9	452637.Oter_2692	2.12e-26	113.0	COG1734@1|root,COG1734@2|Bacteria,46SVY@74201|Verrucomicrobia,3K75N@414999|Opitutae	414999|Opitutae	K	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
CMS2_k127_462242_13	1479237.JMLY01000001_gene3006	8.236e-10	63.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,1SC7M@1236|Gammaproteobacteria,468WS@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	GO:0003674,GO:0004857,GO:0005488,GO:0008150,GO:0008270,GO:0008657,GO:0010911,GO:0030234,GO:0032780,GO:0042030,GO:0043086,GO:0043167,GO:0043169,GO:0043462,GO:0044092,GO:0046872,GO:0046914,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0098772,GO:2000371,GO:2000372	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
CMS2_k127_462242_8	247490.KSU1_B0240	7.301e-29	131.0	2CFWI@1|root,32S2N@2|Bacteria,2J08K@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_462242_1	1232410.KI421414_gene2877	7.922e-176	572.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42MMR@68525|delta/epsilon subdivisions,2WJEB@28221|Deltaproteobacteria,43TVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	GM	Polysaccharide biosynthesis protein CapD	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
CMS2_k127_462242_3	1142394.PSMK_28200	2.761e-97	329.0	COG4974@1|root,COG4974@2|Bacteria,2IX6A@203682|Planctomycetes	203682|Planctomycetes	D	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS2_k127_462242_5	1089553.Tph_c22610	4.801e-79	276.0	COG0731@1|root,COG0731@2|Bacteria,1TSYW@1239|Firmicutes,24CEP@186801|Clostridia,42ID6@68295|Thermoanaerobacterales	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
CMS2_k127_462242_4	338963.Pcar_1944	1.526e-88	299.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria,43T9N@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	DAHP synthetase I family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
CMS2_k127_462242_11	1142394.PSMK_05260	2.468e-17	90.0	COG1437@1|root,COG1437@2|Bacteria	2|Bacteria	F	CYTH domain	cyaB	-	4.6.1.1	ko:K01768,ko:K05873	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CYTH
CMS2_k127_462242_0	717605.Theco_2421	0.0	1121.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,4HAG1@91061|Bacilli,26QCH@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
CMS2_k127_462242_10	1142394.PSMK_06240	7.998e-25	117.0	2DD6P@1|root,2ZGSW@2|Bacteria	2|Bacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
CMS2_k127_462242_12	886293.Sinac_4801	1.583e-15	90.0	COG1538@1|root,COG1538@2|Bacteria,2IXIW@203682|Planctomycetes	203682|Planctomycetes	MU	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_462242_15	59374.Fisuc_0889	0.0007508	51.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS2_k127_462242_6	1049564.TevJSym_az00020	2.499e-40	158.0	COG1285@1|root,COG1285@2|Bacteria,1PD3I@1224|Proteobacteria,1RQXT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
CMS2_k127_462242_7	177437.HRM2_21170	1.56e-31	136.0	COG5036@1|root,COG5036@2|Bacteria,1RG06@1224|Proteobacteria,42RP7@68525|delta/epsilon subdivisions,2WNHW@28221|Deltaproteobacteria,2MN1P@213118|Desulfobacterales	28221|Deltaproteobacteria	P	VTC domain	-	-	-	-	-	-	-	-	-	-	-	-	VTC
CMS2_k127_462242_14	382464.ABSI01000013_gene1549	0.0004135	46.0	COG2312@1|root,COG3211@1|root,COG2312@2|Bacteria,COG3211@2|Bacteria,46XD5@74201|Verrucomicrobia,2IVHX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Fn3_assoc,LTD
CMS2_k127_463000_1	1403819.BATR01000005_gene177	6.73e-32	146.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,46TYP@74201|Verrucomicrobia,2IVFI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	CG	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,VCBS
CMS2_k127_463000_0	1173701.A0A066X787	2.736e-129	453.0	COG4030@1|root,2SKR2@2759|Eukaryota,39W5K@33154|Opisthokonta,3NXCY@4751|Fungi,3QPYP@4890|Ascomycota,21CB8@147550|Sordariomycetes,1EY29@1028384|Glomerellales	4751|Fungi	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
CMS2_k127_463000_2	1396141.BATP01000030_gene3719	1.036e-14	78.0	COG3119@1|root,COG3211@1|root,COG3656@1|root,COG5337@1|root,COG3119@2|Bacteria,COG3211@2|Bacteria,COG3656@2|Bacteria,COG5337@2|Bacteria	2|Bacteria	M	Spore coat protein CotH	phoX	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	CotH,DUF839
CMS2_k127_4654527_3	313628.LNTAR_22409	4.456e-55	196.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
CMS2_k127_4654527_2	1123508.JH636439_gene665	7.246e-56	211.0	COG3345@1|root,COG3345@2|Bacteria,2IZER@203682|Planctomycetes	203682|Planctomycetes	G	Carbohydrate esterase, sialic acid-specific acetylesterase	-	-	-	-	-	-	-	-	-	-	-	-	SASA
CMS2_k127_4654527_0	497964.CfE428DRAFT_0038	4.731e-274	851.0	28MCY@1|root,2ZAQW@2|Bacteria,46TDW@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4654527_1	1499967.BAYZ01000130_gene2591	2.689e-106	355.0	COG1760@1|root,COG1760@2|Bacteria,2NQRY@2323|unclassified Bacteria	2|Bacteria	E	Serine dehydratase alpha chain	-	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
CMS2_k127_465837_6	316274.Haur_0645	0.0008041	47.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS2_k127_465837_3	1396141.BATP01000027_gene1160	1.203e-13	83.0	COG2273@1|root,COG2755@1|root,COG3064@1|root,COG3291@1|root,COG5306@1|root,COG2273@2|Bacteria,COG2755@2|Bacteria,COG3064@2|Bacteria,COG3291@2|Bacteria,COG5306@2|Bacteria,46X9M@74201|Verrucomicrobia,2IV4C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EGM	Peptidase M60-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,M60-like_N,PA14,Peptidase_M60
CMS2_k127_465837_1	1396141.BATP01000019_gene1732	1.041e-25	120.0	COG1595@1|root,COG1595@2|Bacteria,46V3P@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
CMS2_k127_465837_0	595460.RRSWK_04778	3.003e-115	420.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12,TPR_8
CMS2_k127_465837_4	485913.Krac_12315	6.531e-09	65.0	COG0582@1|root,COG0582@2|Bacteria,2G7XX@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
CMS2_k127_465837_2	1142394.PSMK_24200	4.349e-21	95.0	COG0776@1|root,COG0776@2|Bacteria,2J01P@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the bacterial histone-like protein family	-	-	-	ko:K03530,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS2_k127_4670905_1	1340493.JNIF01000003_gene4569	2.816e-34	147.0	COG3356@1|root,COG3356@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
CMS2_k127_4670905_0	886293.Sinac_7479	1.09e-81	303.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
CMS2_k127_4679605_0	1267535.KB906767_gene1553	5.671e-206	665.0	COG4225@1|root,COG4225@2|Bacteria	2|Bacteria	S	unsaturated chondroitin disaccharide hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
CMS2_k127_4679605_1	756272.Plabr_2092	9.354e-164	529.0	COG3119@1|root,COG3119@2|Bacteria,2J24M@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_4679605_3	1179778.PMM47T1_01615	4.087e-70	256.0	COG3664@1|root,COG3664@2|Bacteria,1N6DF@1224|Proteobacteria,1SC0R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	PFAM glycoside hydrolase family 39	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4679605_2	448385.sce0958	7.383e-137	461.0	COG0574@1|root,COG0574@2|Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
CMS2_k127_4685597_5	411901.BACCAC_01380	1.154e-64	228.0	COG3119@1|root,COG3119@2|Bacteria,4NF1X@976|Bacteroidetes,2FP6T@200643|Bacteroidia,4AKST@815|Bacteroidaceae	976|Bacteroidetes	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_4685597_1	926562.Oweho_2900	1.882e-188	610.0	COG1874@1|root,COG3211@1|root,COG1874@2|Bacteria,COG3211@2|Bacteria,4NEFS@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_6,Glyco_hydro_42
CMS2_k127_4685597_2	1185876.BN8_01995	1.858e-178	572.0	COG3119@1|root,COG3119@2|Bacteria,4NEM3@976|Bacteroidetes,47M3C@768503|Cytophagia	976|Bacteroidetes	P	PFAM sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_4685597_4	234267.Acid_7523	6.02e-136	450.0	COG0612@1|root,COG0612@2|Bacteria,3Y322@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_4685597_3	234267.Acid_7524	5.199e-151	492.0	COG0612@1|root,COG0612@2|Bacteria,3Y3XF@57723|Acidobacteria	57723|Acidobacteria	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS2_k127_4685597_6	304371.MCP_1279	1.579e-12	78.0	COG1266@1|root,arCOG02767@2157|Archaea	2157|Archaea	S	metal-dependent membrane protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
CMS2_k127_4685597_0	760192.Halhy_3656	2.966e-194	616.0	COG4946@1|root,COG4946@2|Bacteria,4NJFC@976|Bacteroidetes,1IW2A@117747|Sphingobacteriia	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_468975_6	478741.JAFS01000002_gene886	4.294e-28	130.0	COG0681@1|root,COG0681@2|Bacteria,46SR0@74201|Verrucomicrobia,37FWK@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	U	Signal peptidase, peptidase S26	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
CMS2_k127_468975_10	287.DR97_2356	0.0004293	53.0	COG4641@1|root,COG4641@2|Bacteria,1QDHK@1224|Proteobacteria,1T9I5@1236|Gammaproteobacteria,1YCZR@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
CMS2_k127_468975_7	439235.Dalk_1042	1.452e-25	118.0	COG1216@1|root,COG4122@1|root,COG1216@2|Bacteria,COG4122@2|Bacteria,1N2AR@1224|Proteobacteria,42R09@68525|delta/epsilon subdivisions,2WMWB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
CMS2_k127_468975_1	926550.CLDAP_22570	5.205e-112	372.0	COG1158@1|root,COG1158@2|Bacteria,2G5UQ@200795|Chloroflexi	200795|Chloroflexi	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_RNA_bind
CMS2_k127_468975_9	1123320.KB889698_gene9323	3.489e-09	70.0	COG2133@1|root,COG3055@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3055@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Calx-beta,GSDH,Laminin_G_3,Malectin,PKD
CMS2_k127_468975_4	1089547.KB913013_gene3455	1.388e-33	148.0	COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,47MTM@768503|Cytophagia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
CMS2_k127_468975_0	756272.Plabr_0707	4.741e-143	492.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,TPR_8
CMS2_k127_468975_2	886293.Sinac_4026	7.001e-69	240.0	COG1595@1|root,COG1595@2|Bacteria,2IZ8A@203682|Planctomycetes	203682|Planctomycetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_468975_3	530564.Psta_2826	3.138e-44	170.0	COG1762@1|root,COG1762@2|Bacteria,2IZFY@203682|Planctomycetes	203682|Planctomycetes	G	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
CMS2_k127_468975_5	1123508.JH636441_gene3117	4.236e-30	131.0	COG1413@1|root,COG1413@2|Bacteria,2J2VX@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_468975_8	1392488.JHZY01000004_gene1984	7.262e-11	74.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cadherin-like,Calx-beta,LTD,PKD,SLH
CMS2_k127_4716428_6	1121382.JQKG01000023_gene1514	1.385e-41	156.0	COG0066@1|root,COG0066@2|Bacteria,1WIV4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
CMS2_k127_4716428_7	1234364.AMSF01000013_gene639	7.607e-05	53.0	295WS@1|root,2ZT7P@2|Bacteria,1P63I@1224|Proteobacteria,1SVPU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4716428_2	1434325.AZQN01000004_gene1658	4.621e-155	506.0	COG3119@1|root,COG3119@2|Bacteria,4NF1X@976|Bacteroidetes,47MQK@768503|Cytophagia	976|Bacteroidetes	P	Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_4716428_0	314230.DSM3645_02338	1.012e-202	642.0	COG3119@1|root,COG3119@2|Bacteria,2IX9T@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_4716428_1	289376.THEYE_A0114	6.158e-171	542.0	COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae	40117|Nitrospirae	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CMS2_k127_4716428_4	1519464.HY22_02245	1.256e-54	195.0	COG4914@1|root,COG4914@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204
CMS2_k127_4716428_3	398512.JQKC01000004_gene5249	1.364e-149	504.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia,3WI29@541000|Ruminococcaceae	186801|Clostridia	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS2_k127_4716428_5	398512.JQKC01000004_gene5249	1.165e-48	180.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia,3WI29@541000|Ruminococcaceae	186801|Clostridia	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS2_k127_4735813_3	861299.J421_1405	4.942e-16	85.0	2A4E9@1|root,2ZJRI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4735813_2	246200.SPO3316a	4.509e-22	102.0	COG3871@1|root,COG3871@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS2_k127_4735813_1	1340493.JNIF01000003_gene2252	8.546e-136	445.0	COG2942@1|root,COG2942@2|Bacteria	2|Bacteria	G	2-epimerase	-	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
CMS2_k127_4735813_0	344747.PM8797T_07534	1.146e-175	557.0	COG1073@1|root,COG1073@2|Bacteria,2IWT8@203682|Planctomycetes	203682|Planctomycetes	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_474136_1	583355.Caka_0957	3.867e-90	313.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C,TAT_signal
CMS2_k127_474136_2	1122970.AUHC01000025_gene25	8.937e-11	72.0	2BWMX@1|root,2ZIUW@2|Bacteria,1RKH7@1224|Proteobacteria,2U600@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_474136_0	1521187.JPIM01000022_gene637	8.035e-110	362.0	COG4422@1|root,COG4422@2|Bacteria,2G7TP@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF5131)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5131
CMS2_k127_4743077_1	1379698.RBG1_1C00001G1531	7.302e-101	350.0	COG0123@1|root,COG0123@2|Bacteria,2NPB6@2323|unclassified Bacteria	2|Bacteria	BQ	Histone deacetylase domain	acuC	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
CMS2_k127_4743077_0	1121405.dsmv_2071	1.404e-103	352.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,42MIR@68525|delta/epsilon subdivisions,2WMEK@28221|Deltaproteobacteria,2MJC8@213118|Desulfobacterales	28221|Deltaproteobacteria	M	MBOAT, membrane-bound O-acyltransferase family	algI	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
CMS2_k127_4743077_2	497964.CfE428DRAFT_4368	6.215e-10	63.0	COG1520@1|root,COG1520@2|Bacteria,46U89@74201|Verrucomicrobia	2|Bacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566,PQQ_2,PQQ_3
CMS2_k127_4758111_1	616991.JPOO01000003_gene2370	2.605e-234	735.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1I0X7@117743|Flavobacteriia,23FWQ@178469|Arenibacter	976|Bacteroidetes	E	Sodium:solute symporter family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_4758111_8	143224.JQMD01000002_gene243	2.261e-14	74.0	2E97G@1|root,333FY@2|Bacteria,4NWTY@976|Bacteroidetes,1I5KD@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4758111_3	616991.JPOO01000003_gene2365	7.255e-196	618.0	COG0399@1|root,COG0399@2|Bacteria,4NG9W@976|Bacteroidetes,1HZDU@117743|Flavobacteriia,23H42@178469|Arenibacter	976|Bacteroidetes	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_4758111_0	1121012.AUKX01000010_gene2024	8.357e-317	996.0	COG3250@1|root,COG3250@2|Bacteria,4NE7H@976|Bacteroidetes,1HX95@117743|Flavobacteriia,23FNZ@178469|Arenibacter	976|Bacteroidetes	G	Glycosyl hydrolases family 2, TIM barrel domain	-	-	3.2.1.165	ko:K15855	ko00520,ko01100,map00520,map01100	-	R01966	RC00049	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
CMS2_k127_4758111_2	1288963.ADIS_1090	1.374e-218	700.0	COG3292@1|root,COG3292@2|Bacteria,4NE4U@976|Bacteroidetes,47JHS@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4758111_7	237368.SCABRO_02484	2.996e-46	185.0	COG0642@1|root,COG2205@2|Bacteria	237368.SCABRO_02484|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4758111_6	344747.PM8797T_31628	5.09e-66	243.0	COG3842@1|root,COG3842@2|Bacteria,2IZ85@203682|Planctomycetes	203682|Planctomycetes	E	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS2_k127_4758111_4	1210884.HG799469_gene14024	2.249e-89	307.0	COG0555@1|root,COG0555@2|Bacteria,2IYJ3@203682|Planctomycetes	203682|Planctomycetes	O	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS2_k127_4758111_5	344747.PM8797T_31638	3.836e-72	250.0	COG0725@1|root,COG0725@2|Bacteria,2J08C@203682|Planctomycetes	203682|Planctomycetes	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11
CMS2_k127_4761204_2	1408254.T458_16605	1.808e-70	252.0	COG4584@1|root,COG4584@2|Bacteria,1UW0T@1239|Firmicutes,4HB6H@91061|Bacilli	91061|Bacilli	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
CMS2_k127_4761204_0	1123242.JH636435_gene1779	3.212e-211	668.0	COG3119@1|root,COG3119@2|Bacteria,2IYFP@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_4761204_1	1265503.KB905160_gene2810	5.185e-182	583.0	COG3669@1|root,COG3669@2|Bacteria,1N8B5@1224|Proteobacteria,1RWUY@1236|Gammaproteobacteria,2Q842@267889|Colwelliaceae	1236|Gammaproteobacteria	G	Alpha-L-fucosidase	fucA1	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Fucosidase_C
CMS2_k127_4761906_0	1167006.UWK_00092	1.374e-142	467.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2MHQS@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
CMS2_k127_4761906_6	589865.DaAHT2_0104	1.376e-103	344.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria,2MJJN@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS2_k127_4761906_4	1167006.UWK_00090	6.909e-131	428.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42TE0@68525|delta/epsilon subdivisions,2WPEP@28221|Deltaproteobacteria,2MKDG@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS2_k127_4761906_8	1167006.UWK_00089	9.642e-89	300.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NMG@68525|delta/epsilon subdivisions,2WJIS@28221|Deltaproteobacteria,2MIA1@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	livG	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
CMS2_k127_4761906_10	1121403.AUCV01000001_gene872	2.556e-85	289.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M5A@68525|delta/epsilon subdivisions,2WK03@28221|Deltaproteobacteria,2MJNZ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
CMS2_k127_4761906_3	338966.Ppro_1754	4.294e-138	451.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42MSQ@68525|delta/epsilon subdivisions,2WISJ@28221|Deltaproteobacteria,43UEN@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-1	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
CMS2_k127_4761906_17	1123508.JH636439_gene1078	2.046e-12	78.0	COG2165@1|root,COG2165@2|Bacteria,2IYXI@203682|Planctomycetes	203682|Planctomycetes	NU	Protein of unknown function (DUF1559)	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_4761906_1	504472.Slin_0603	2.798e-140	458.0	COG0399@1|root,COG0399@2|Bacteria,4NG9W@976|Bacteroidetes,47NYY@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_4761906_7	221027.JO40_10595	7.597e-93	316.0	COG3525@1|root,COG3525@2|Bacteria,2J6I8@203691|Spirochaetes	203691|Spirochaetes	G	hydrolase family 20, catalytic	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	Glyco_hydro_20,Glyco_hydro_20b
CMS2_k127_4761906_15	1294273.roselon_00827	2.465e-41	154.0	COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,2U595@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG1956 GAF domain-containing protein	msrC	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF_2
CMS2_k127_4761906_18	1569209.BBPH01000025_gene225	1.812e-07	54.0	COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,2U595@28211|Alphaproteobacteria,2PU3G@265|Paracoccus	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	msrC	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF_2
CMS2_k127_4761906_12	530564.Psta_2328	3.702e-71	249.0	COG3342@1|root,COG3342@2|Bacteria,2J3RN@203682|Planctomycetes	203682|Planctomycetes	M	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028
CMS2_k127_4761906_2	398767.Glov_2977	3.748e-138	450.0	COG1168@1|root,COG1168@2|Bacteria,1MY33@1224|Proteobacteria,42M6F@68525|delta/epsilon subdivisions,2WK37@28221|Deltaproteobacteria,43TKI@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	-	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS2_k127_4761906_14	314230.DSM3645_14090	7.568e-54	209.0	COG1413@1|root,COG3828@1|root,COG1413@2|Bacteria,COG3828@2|Bacteria,2IX8S@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_4761906_19	1396141.BATP01000016_gene2804	9.418e-06	58.0	COG1082@1|root,COG1082@2|Bacteria,46UG0@74201|Verrucomicrobia,2IUX7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_4761906_9	452637.Oter_3509	4.424e-88	308.0	COG0673@1|root,COG0673@2|Bacteria,46TMZ@74201|Verrucomicrobia,3K8Y2@414999|Opitutae	414999|Opitutae	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_4761906_13	1499967.BAYZ01000123_gene2538	3.174e-61	215.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS2_k127_4761906_5	452637.Oter_2975	9.825e-106	357.0	COG0673@1|root,COG0673@2|Bacteria,46UJ9@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_4761906_11	383372.Rcas_3813	1.454e-84	297.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	stsA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576	2.6.1.109	ko:K19715	-	-	R11395	RC00160	ko00000,ko01000,ko01005	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_4761906_16	439235.Dalk_2288	1.96e-15	85.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,2MPW6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4150,RHS,RHS_repeat,Transglut_core
CMS2_k127_4772903_7	1492737.FEM08_26230	5.601e-13	75.0	COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,1I0G9@117743|Flavobacteriia,2NTFA@237|Flavobacterium	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4772903_5	468059.AUHA01000004_gene2375	7.498e-25	115.0	2BXBG@1|root,33WQF@2|Bacteria,4P3CB@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4772903_4	234267.Acid_5757	2.785e-25	116.0	COG1595@1|root,COG1595@2|Bacteria,3Y8YQ@57723|Acidobacteria	57723|Acidobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4772903_0	1267535.KB906767_gene447	5.333e-147	492.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria,2JMN2@204432|Acidobacteriia	204432|Acidobacteriia	T	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
CMS2_k127_4772903_2	1267533.KB906734_gene4055	1.462e-62	234.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,TPR_8
CMS2_k127_4772903_8	794903.OPIT5_23905	1.045e-07	63.0	COG2165@1|root,COG2165@2|Bacteria,46Z9G@74201|Verrucomicrobia,3K9NR@414999|Opitutae	2|Bacteria	U	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_4772903_1	96561.Dole_1704	8.598e-80	304.0	COG3420@1|root,COG3420@2|Bacteria,1MZHI@1224|Proteobacteria,43BRC@68525|delta/epsilon subdivisions,2WUM4@28221|Deltaproteobacteria,2MN6K@213118|Desulfobacterales	1224|Proteobacteria	P	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4772903_6	290402.Cbei_2641	3.071e-16	92.0	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,247V6@186801|Clostridia,36F0S@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	ko:K14059	-	-	-	-	ko00000	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
CMS2_k127_4772903_3	886293.Sinac_4026	3.301e-57	210.0	COG1595@1|root,COG1595@2|Bacteria,2IZ8A@203682|Planctomycetes	203682|Planctomycetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_4773038_0	700598.Niako_3607	0.0	1244.0	COG5434@1|root,COG5434@2|Bacteria,4NE4H@976|Bacteroidetes,1IQG1@117747|Sphingobacteriia	976|Bacteroidetes	M	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4773038_8	1396141.BATP01000027_gene1160	5.144e-29	136.0	COG2273@1|root,COG2755@1|root,COG3064@1|root,COG3291@1|root,COG5306@1|root,COG2273@2|Bacteria,COG2755@2|Bacteria,COG3064@2|Bacteria,COG3291@2|Bacteria,COG5306@2|Bacteria,46X9M@74201|Verrucomicrobia,2IV4C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EGM	Peptidase M60-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,M60-like_N,PA14,Peptidase_M60
CMS2_k127_4773038_10	59374.Fisuc_2002	1.422e-10	76.0	COG3866@1|root,COG4733@1|root,COG3866@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Laminin_G_3,fn3
CMS2_k127_4773038_7	13035.Dacsa_2125	6.799e-32	146.0	COG1028@1|root,COG2931@1|root,COG5306@1|root,COG1028@2|Bacteria,COG2931@2|Bacteria,COG5306@2|Bacteria,1G2IN@1117|Cyanobacteria	1117|Cyanobacteria	IQ	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4773038_9	1291050.JAGE01000001_gene149	7.98e-22	113.0	COG2373@1|root,COG3401@1|root,COG2373@2|Bacteria,COG3401@2|Bacteria,1VRAF@1239|Firmicutes,24BEM@186801|Clostridia	2|Bacteria	U	Calx-beta domain	-	-	3.4.24.40	ko:K01406,ko:K20444	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Big_5,CBM_35,CBM_6,Calx-beta,He_PIG,Kelch_1,Malectin
CMS2_k127_4773038_2	452637.Oter_2156	9.477e-182	581.0	COG5297@1|root,COG5297@2|Bacteria,46TK0@74201|Verrucomicrobia,3K9EZ@414999|Opitutae	414999|Opitutae	G	Protein of unknown function (DUF1593)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1593
CMS2_k127_4773038_1	714943.Mucpa_6740	1.127e-247	806.0	COG3533@1|root,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes,1IPRQ@117747|Sphingobacteriia	976|Bacteroidetes	S	glycosyl hydrolase of	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
CMS2_k127_4773038_3	1121887.AUDK01000012_gene1594	3.585e-181	610.0	COG1626@1|root,COG1626@2|Bacteria,4PMI4@976|Bacteroidetes,1ICN4@117743|Flavobacteriia,2NTMG@237|Flavobacterium	976|Bacteroidetes	G	Trehalase	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
CMS2_k127_4773038_4	382464.ABSI01000010_gene3488	9.052e-77	278.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_4773038_5	887062.HGR_08184	5.989e-76	267.0	COG2084@1|root,COG2084@2|Bacteria,1MUD0@1224|Proteobacteria,2VKIK@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Dehydrogenase	garR	-	1.1.1.31,1.1.1.411	ko:K00020,ko:K08319	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
CMS2_k127_4773038_6	1123242.JH636435_gene769	1.057e-36	145.0	2DBNR@1|root,2ZA54@2|Bacteria,2IYX9@203682|Planctomycetes	203682|Planctomycetes	S	Methane oxygenase PmoA	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
CMS2_k127_4801271_3	1278307.KB906968_gene2032	3.193e-30	121.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SWYU@1236|Gammaproteobacteria,2QJ81@267894|Psychromonadaceae	1236|Gammaproteobacteria	K	Ribonuclease B OB domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CMS2_k127_4801271_0	1499967.BAYZ01000035_gene1060	6.663e-203	642.0	COG1032@1|root,COG1032@2|Bacteria,2NQAV@2323|unclassified Bacteria	2|Bacteria	C	Domain of unknown function (DUF4070)	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_4801271_1	452637.Oter_3509	2.287e-139	455.0	COG0673@1|root,COG0673@2|Bacteria,46TMZ@74201|Verrucomicrobia,3K8Y2@414999|Opitutae	414999|Opitutae	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_4801271_2	382464.ABSI01000011_gene2466	2.206e-36	154.0	COG2982@1|root,COG3055@1|root,COG3507@1|root,COG4733@1|root,COG2982@2|Bacteria,COG3055@2|Bacteria,COG3507@2|Bacteria,COG4733@2|Bacteria,46W6Z@74201|Verrucomicrobia	2|Bacteria	GMOU	Fibronectin type 3 domain	-	-	1.16.3.3	ko:K22350	-	-	-	-	ko00000,ko01000	-	-	-	AsmA_2,Beta_helix,Big_2,CBM_6,DUF1349,DUF748,GSDH,Glyco_hydro_43,Laminin_G_3,PKD,Phage-tail_3,SLH
CMS2_k127_4804419_1	344747.PM8797T_27367	1.466e-57	207.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_4804419_0	234267.Acid_5676	7.914e-201	666.0	COG0515@1|root,COG1262@1|root,COG1506@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	1.14.99.50,2.7.11.1	ko:K01990,ko:K08884,ko:K12132,ko:K18912	ko00340,map00340	M00254	R11013	RC03323,RC03324	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000	3.A.1	-	-	FGE-sulfatase,Peptidase_S15,Pkinase
CMS2_k127_4804419_3	742766.HMPREF9455_01937	5.693e-40	169.0	COG3292@1|root,COG3292@2|Bacteria,4NI2T@976|Bacteroidetes,2FV1K@200643|Bacteroidia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	Reg_prop,YceI
CMS2_k127_4804419_4	1122609.AUGT01000008_gene2868	2.647e-14	87.0	COG0366@1|root,COG0515@1|root,COG2133@1|root,COG3227@1|root,COG4733@1|root,COG0366@2|Bacteria,COG0515@2|Bacteria,COG2133@2|Bacteria,COG3227@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.3	ko:K01178,ko:K14645,ko:K18546	ko00500,ko01100,ko02024,map00500,map01100,map02024	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH15	-	Alpha-amylase,GSDH,He_PIG,PKD,Pro_Al_protease,SLH,Trypsin,fn3
CMS2_k127_4804419_5	1121904.ARBP01000001_gene5706	1.064e-12	78.0	COG2885@1|root,COG2885@2|Bacteria,4NJB2@976|Bacteroidetes,47K81@768503|Cytophagia	976|Bacteroidetes	MU	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	PD40
CMS2_k127_4804419_6	86106.I862_02105	0.0001077	50.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
CMS2_k127_4804419_2	502025.Hoch_0991	6.476e-49	179.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,4313Z@68525|delta/epsilon subdivisions,2WX2K@28221|Deltaproteobacteria,2Z2QP@29|Myxococcales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
CMS2_k127_4834143_5	397291.C804_04450	0.0002601	52.0	COG0615@1|root,COG0615@2|Bacteria,1V3KY@1239|Firmicutes,24HAQ@186801|Clostridia,27KZV@186928|unclassified Lachnospiraceae	186801|Clostridia	IM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
CMS2_k127_4834143_2	1120950.KB892759_gene6268	4.929e-12	76.0	COG0558@1|root,COG0558@2|Bacteria,2GN3C@201174|Actinobacteria,4DV9H@85009|Propionibacteriales	201174|Actinobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
CMS2_k127_4834143_1	1121890.AUDO01000007_gene2560	1.924e-26	127.0	COG4124@1|root,COG4124@2|Bacteria,4NIF5@976|Bacteroidetes,1I0PQ@117743|Flavobacteriia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 26 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_26
CMS2_k127_4834143_3	237368.SCABRO_03229	1.244e-06	62.0	COG3291@1|root,COG4733@1|root,COG3291@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Laminin_G_3,PKD,PPC,Phage-tail_3,Reprolysin_3,fn3
CMS2_k127_4834143_0	497964.CfE428DRAFT_2733	2.115e-48	199.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4834143_4	543632.JOJL01000008_gene5599	1.047e-05	54.0	2DBP2@1|root,2ZA71@2|Bacteria,2H3R7@201174|Actinobacteria,4DHXU@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4841937_1	555088.DealDRAFT_2020	2.595e-67	252.0	COG4219@1|root,COG4219@2|Bacteria,1TP3Z@1239|Firmicutes,249NV@186801|Clostridia,42KY1@68298|Syntrophomonadaceae	186801|Clostridia	KT	PFAM peptidase M56 BlaR1	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	NAGPA,Peptidase_M56
CMS2_k127_4841937_3	1536770.R50345_13375	2.353e-34	135.0	COG3682@1|root,COG3682@2|Bacteria,1V7EY@1239|Firmicutes,4HIKG@91061|Bacilli,26YMQ@186822|Paenibacillaceae	91061|Bacilli	K	Penicillinase repressor	-	-	-	ko:K02171	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01504,ko03000	-	-	-	Penicillinase_R
CMS2_k127_4841937_5	533240.CRC_01252	1.315e-18	98.0	COG0834@1|root,COG1404@1|root,COG1409@1|root,COG1520@1|root,COG2133@1|root,COG2931@1|root,COG3386@1|root,COG3537@1|root,COG5164@1|root,COG0834@2|Bacteria,COG1404@2|Bacteria,COG1409@2|Bacteria,COG1520@2|Bacteria,COG2133@2|Bacteria,COG2931@2|Bacteria,COG3386@2|Bacteria,COG3537@2|Bacteria,COG5164@2|Bacteria,1G2N0@1117|Cyanobacteria,1HRSX@1161|Nostocales	1117|Cyanobacteria	GOQ	Calx-beta domain	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Calx-beta,DUF4114,DUF4347,HemolysinCabind,Laminin_G_3,SBP_bac_3,VCBS
CMS2_k127_4841937_7	59374.Fisuc_2002	7.592e-10	73.0	COG3866@1|root,COG4733@1|root,COG3866@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Laminin_G_3,fn3
CMS2_k127_4841937_8	504487.JCM19302_2169	2.979e-06	61.0	2DICN@1|root,32UAX@2|Bacteria,4NU78@976|Bacteroidetes,1I4Y5@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C
CMS2_k127_4841937_4	1117108.PAALTS15_09419	3.242e-28	133.0	COG2133@1|root,COG3291@1|root,COG4733@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,1TR38@1239|Firmicutes,4HBME@91061|Bacilli,26SSJ@186822|Paenibacillaceae	91061|Bacilli	G	Quinoprotein glucose dehydrogenase	gdhB	-	-	-	-	-	-	-	-	-	-	-	GSDH
CMS2_k127_4841937_6	3641.EOY23604	1.114e-11	70.0	COG4281@1|root,KOG0817@2759|Eukaryota,37HHD@33090|Viridiplantae,3G7IU@35493|Streptophyta	35493|Streptophyta	I	acyl-CoA-binding domain-containing protein	-	GO:0000003,GO:0000062,GO:0000166,GO:0001101,GO:0001666,GO:0003006,GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005778,GO:0005783,GO:0005789,GO:0005886,GO:0006629,GO:0006810,GO:0006869,GO:0006950,GO:0007275,GO:0008150,GO:0008152,GO:0008289,GO:0009266,GO:0009409,GO:0009505,GO:0009514,GO:0009628,GO:0009719,GO:0009725,GO:0009737,GO:0009791,GO:0010029,GO:0010033,GO:0010035,GO:0010038,GO:0010154,GO:0010162,GO:0010288,GO:0010431,GO:0010876,GO:0012505,GO:0016020,GO:0017076,GO:0021700,GO:0022414,GO:0022611,GO:0030312,GO:0030554,GO:0031090,GO:0031903,GO:0031984,GO:0032501,GO:0032502,GO:0032504,GO:0032553,GO:0032555,GO:0032559,GO:0032791,GO:0033036,GO:0033218,GO:0033993,GO:0036094,GO:0036293,GO:0042175,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0048037,GO:0048316,GO:0048580,GO:0048608,GO:0048609,GO:0048731,GO:0048856,GO:0050662,GO:0050789,GO:0050793,GO:0050896,GO:0051179,GO:0051234,GO:0051239,GO:0061458,GO:0065007,GO:0070300,GO:0070482,GO:0071695,GO:0071702,GO:0071704,GO:0071944,GO:0097159,GO:0097305,GO:0097367,GO:0098588,GO:0098805,GO:0098827,GO:1900140,GO:1901265,GO:1901363,GO:1901567,GO:1901681,GO:1901700,GO:2000026	-	-	-	-	-	-	-	-	-	-	ACBP,Ank_2,Ank_4,Ank_5
CMS2_k127_4841937_2	452637.Oter_0019	4.584e-46	173.0	COG3449@1|root,COG3449@2|Bacteria	2|Bacteria	K	DNA topoisomerase (ATP-hydrolyzing) inhibitor activity	-	-	-	ko:K13652,ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	Cass2,GyrI-like,HTH_18
CMS2_k127_4841937_0	1434325.AZQN01000001_gene187	1.416e-139	466.0	COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,47T8D@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_484459_1	457570.Nther_0354	4.451e-12	79.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Beta_helix
CMS2_k127_484459_0	1195236.CTER_4883	6.161e-120	411.0	COG2006@1|root,COG2006@2|Bacteria,1VRZ8@1239|Firmicutes,24Z9V@186801|Clostridia,3WN5G@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Dockerin_1
CMS2_k127_484459_2	1142394.PSMK_31570	2.964e-08	65.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_486049_10	234267.Acid_0198	2.551e-66	235.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,DUF3298,DUF4163,Glyco_hydro_9,Polysacc_deac_1
CMS2_k127_486049_0	530564.Psta_0688	8.191e-199	635.0	28MMN@1|root,2ZAXE@2|Bacteria,2IY1P@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_486049_16	595536.ADVE02000001_gene2312	4.089e-33	139.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TUND@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	response regulator	fixJ	-	-	ko:K14987	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
CMS2_k127_486049_15	1120949.KB903294_gene3896	4.483e-43	182.0	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,2GZ7K@201174|Actinobacteria,4DF55@85008|Micromonosporales	201174|Actinobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
CMS2_k127_486049_3	240016.ABIZ01000001_gene5157	3.066e-110	371.0	COG0577@1|root,COG0577@2|Bacteria,46TQS@74201|Verrucomicrobia,2IWMB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS2_k127_486049_7	1167006.UWK_02171	4.694e-76	265.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2WMVB@28221|Deltaproteobacteria,2MQ2W@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_486049_6	1396418.BATQ01000030_gene5616	2.614e-82	295.0	COG0845@1|root,COG0845@2|Bacteria,46WF0@74201|Verrucomicrobia	74201|Verrucomicrobia	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
CMS2_k127_486049_9	240016.ABIZ01000001_gene5154	2.246e-68	255.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_486049_12	211165.AJLN01000088_gene2607	1.042e-57	224.0	COG0745@1|root,COG5000@1|root,COG0745@2|Bacteria,COG5000@2|Bacteria,1GPZW@1117|Cyanobacteria,1JI0S@1189|Stigonemataceae	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
CMS2_k127_486049_17	1121939.L861_17695	9.371e-28	117.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S5UT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Response regulator receiver	pilH	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
CMS2_k127_486049_21	555079.Toce_1922	0.0001656	54.0	COG4972@1|root,COG4972@2|Bacteria,1V19I@1239|Firmicutes,259HF@186801|Clostridia,42HBP@68295|Thermoanaerobacterales	186801|Clostridia	NU	COGs COG4972 Tfp pilus assembly protein ATPase PilM	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
CMS2_k127_486049_20	1266908.AQPB01000043_gene1433	8.145e-05	53.0	COG4970@1|root,COG4970@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	-	-	-	ko:K02246,ko:K10926	ko05111,map05111	M00429	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	GspH,N_methyl
CMS2_k127_486049_18	401526.TcarDRAFT_1560	1.793e-08	59.0	COG4968@1|root,COG4968@2|Bacteria,1VD7G@1239|Firmicutes,4H9AT@909932|Negativicutes	909932|Negativicutes	U	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,T2SSG
CMS2_k127_486049_11	35754.JNYJ01000043_gene4429	1.478e-65	239.0	COG1459@1|root,COG1459@2|Bacteria,2GQW0@201174|Actinobacteria,4DB2E@85008|Micromonosporales	201174|Actinobacteria	NU	Type II secretion system (T2SS), protein F	tapC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
CMS2_k127_486049_2	401526.TcarDRAFT_1563	5.638e-144	475.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4H2AT@909932|Negativicutes	909932|Negativicutes	NU	Type II IV secretion system protein	epsE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
CMS2_k127_486049_19	397278.JOJN01000007_gene3119	3.863e-07	57.0	COG2197@1|root,COG2197@2|Bacteria,2GN80@201174|Actinobacteria,4DQ84@85009|Propionibacteriales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS2_k127_486049_1	1121904.ARBP01000018_gene2704	3.278e-147	482.0	COG4409@1|root,COG4409@2|Bacteria,4NIJX@976|Bacteroidetes,47MH2@768503|Cytophagia	976|Bacteroidetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
CMS2_k127_486049_4	1123242.JH636435_gene1369	2.792e-105	361.0	28KPG@1|root,2ZA7K@2|Bacteria,2J1E2@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_486049_8	927658.AJUM01000017_gene3077	4.983e-71	256.0	COG0667@1|root,COG0667@2|Bacteria,4PPAM@976|Bacteroidetes,2G14T@200643|Bacteroidia	976|Bacteroidetes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS2_k127_486049_5	575540.Isop_2794	7.757e-94	327.0	COG1249@1|root,COG1249@2|Bacteria,2IX5H@203682|Planctomycetes	203682|Planctomycetes	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3)	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
CMS2_k127_486049_14	913865.DOT_0088	2.174e-46	178.0	COG0320@1|root,COG0321@1|root,COG0320@2|Bacteria,COG0321@2|Bacteria,1TQM4@1239|Firmicutes,2495Q@186801|Clostridia,2619Z@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,LIAS_N,Radical_SAM
CMS2_k127_486049_13	1121013.P873_08240	1.487e-47	183.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1X4DA@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
CMS2_k127_4874845_3	517418.Ctha_1865	3.031e-60	234.0	COG5184@1|root,COG5492@1|root,COG5184@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,CHU_C,Calx-beta,ChW,Flg_new,Glug,Phage_TTP_12,RCC1
CMS2_k127_4874845_4	251229.Chro_2495	1.627e-37	149.0	COG4625@1|root,COG4625@2|Bacteria,1G7EK@1117|Cyanobacteria	1117|Cyanobacteria	S	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4874845_2	1131269.AQVV01000001_gene1363	3.17e-73	267.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS2_k127_4874845_0	401526.TcarDRAFT_1563	2.844e-151	498.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4H2AT@909932|Negativicutes	909932|Negativicutes	NU	Type II IV secretion system protein	epsE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
CMS2_k127_4874845_1	1142394.PSMK_16780	1.644e-80	284.0	COG1459@1|root,COG1459@2|Bacteria,2IXYZ@203682|Planctomycetes	203682|Planctomycetes	U	Type 4 fimbrial assembly protein pilC	-	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
CMS2_k127_4894377_5	314230.DSM3645_08822	1.733e-41	166.0	COG0204@1|root,COG0204@2|Bacteria,2IZVC@203682|Planctomycetes	203682|Planctomycetes	I	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS2_k127_4894377_4	575540.Isop_0630	4.308e-53	195.0	COG0283@1|root,COG0283@2|Bacteria,2IZ6S@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
CMS2_k127_4894377_2	1142394.PSMK_27340	2.747e-66	244.0	COG2208@1|root,COG4936@1|root,COG2208@2|Bacteria,COG4936@2|Bacteria,2IWVF@203682|Planctomycetes	203682|Planctomycetes	T	FHA domain	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	FHA,GAF_2,SpoIIE
CMS2_k127_4894377_1	1499967.BAYZ01000103_gene3758	2.491e-84	305.0	COG0457@1|root,COG0457@2|Bacteria	1499967.BAYZ01000103_gene3758|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4894377_6	1396141.BATP01000023_gene568	2.486e-16	81.0	COG1254@1|root,COG1254@2|Bacteria,46W9W@74201|Verrucomicrobia,2IUZQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Acylphosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Acylphosphatase
CMS2_k127_4894377_3	1121935.AQXX01000117_gene5104	1.212e-58	208.0	arCOG05193@1|root,2ZZSG@2|Bacteria,1REJB@1224|Proteobacteria,1SQYC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4894377_0	886293.Sinac_4679	5.345e-175	570.0	2DBKQ@1|root,2Z9U7@2|Bacteria,2IWVD@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4894377_8	1121468.AUBR01000094_gene767	0.0004809	47.0	COG0526@1|root,COG0526@2|Bacteria,1V7JP@1239|Firmicutes,25ET7@186801|Clostridia,42JE2@68295|Thermoanaerobacterales	186801|Clostridia	CO	Thioredoxin-like	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,Redoxin
CMS2_k127_4894377_7	1287475.HMPREF1650_12015	0.0001727	48.0	COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,22MX4@1653|Corynebacteriaceae	201174|Actinobacteria	O	bacterioferritin comigratory protein	bcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
CMS2_k127_4895355_4	1210884.HG799470_gene14433	4.691e-36	146.0	COG1595@1|root,COG1595@2|Bacteria,2IZ91@203682|Planctomycetes	203682|Planctomycetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_4895355_1	706587.Desti_3270	6.606e-69	263.0	COG2202@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
CMS2_k127_4895355_2	909663.KI867150_gene1087	3.961e-54	216.0	COG2202@1|root,COG2203@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675,ko:K09684	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko03000	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,MASE1,PAS,PAS_3,PAS_4,PAS_9,Peripla_BP_3,Response_reg,dCache_2
CMS2_k127_4895355_0	909663.KI867150_gene1086	2.198e-77	267.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42N8J@68525|delta/epsilon subdivisions,2WK63@28221|Deltaproteobacteria,2MRGY@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS2_k127_4895355_5	1485544.JQKP01000011_gene778	3.423e-27	119.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VQ9H@28216|Betaproteobacteria,44VRB@713636|Nitrosomonadales	28216|Betaproteobacteria	K	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS2_k127_4895355_3	234267.Acid_2608	3.944e-38	151.0	COG1661@1|root,COG1661@2|Bacteria	2|Bacteria	O	DNA-binding protein with PD1-like DNA-binding motif	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296,Glutaredoxin
CMS2_k127_4908926_9	344747.PM8797T_31638	4.642e-72	252.0	COG0725@1|root,COG0725@2|Bacteria,2J08C@203682|Planctomycetes	203682|Planctomycetes	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11
CMS2_k127_4908926_18	1009370.ALO_03031	5.49e-12	73.0	COG0730@1|root,COG0730@2|Bacteria,1VAMI@1239|Firmicutes,4H54C@909932|Negativicutes	909932|Negativicutes	S	membrane transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	TauE
CMS2_k127_4908926_15	1125863.JAFN01000001_gene2102	8.187e-26	116.0	COG0725@1|root,COG0725@2|Bacteria,1QD9D@1224|Proteobacteria,42QRE@68525|delta/epsilon subdivisions,2WMW0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
CMS2_k127_4908926_17	1166948.JPZL01000003_gene790	4.762e-18	87.0	COG0599@1|root,COG0599@2|Bacteria,1N2ZQ@1224|Proteobacteria,1SBZC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS2_k127_4908926_14	439235.Dalk_2340	2.1e-46	178.0	COG1418@1|root,COG1418@2|Bacteria,1R60M@1224|Proteobacteria,42NFJ@68525|delta/epsilon subdivisions,2WIJT@28221|Deltaproteobacteria,2MJ3J@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM metal-dependent phosphohydrolase HD sub	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS2_k127_4908926_11	1131462.DCF50_p297	4.061e-62	242.0	COG0685@1|root,COG0685@2|Bacteria,1W739@1239|Firmicutes,25NME@186801|Clostridia,260RW@186807|Peptococcaceae	186801|Clostridia	E	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,MTHFR_C
CMS2_k127_4908926_13	903818.KI912268_gene1121	7.788e-51	190.0	COG1526@1|root,COG1526@2|Bacteria	2|Bacteria	C	Mo-molybdopterin cofactor metabolic process	fdhD	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0043085,GO:0043546,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0050790,GO:0065007,GO:0065009,GO:0097159,GO:0097163,GO:0140104,GO:1901363	-	ko:K02379,ko:K18360	ko00360,map00360	-	R07222,R07294	RC00004,RC01844,RC01903	ko00000,ko00001	-	-	-	FdhD-NarQ
CMS2_k127_4908926_7	1232410.KI421413_gene477	1.508e-102	353.0	COG1139@1|root,COG1139@2|Bacteria,1NS3B@1224|Proteobacteria,42Y64@68525|delta/epsilon subdivisions,2WTW2@28221|Deltaproteobacteria,43TRA@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
CMS2_k127_4908926_1	1232410.KI421413_gene476	7.782e-303	941.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,43VZE@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
CMS2_k127_4908926_6	1232410.KI421413_gene475	9.076e-106	350.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WNRN@28221|Deltaproteobacteria,43U95@69541|Desulfuromonadales	28221|Deltaproteobacteria	CH	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
CMS2_k127_4908926_16	335543.Sfum_1719	1.008e-23	109.0	2C5Z2@1|root,32U5Z@2|Bacteria,1N4MT@1224|Proteobacteria,42TX0@68525|delta/epsilon subdivisions,2WQZM@28221|Deltaproteobacteria,2MS8T@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
CMS2_k127_4908926_10	237368.SCABRO_01683	2.134e-70	246.0	COG3640@1|root,COG3640@2|Bacteria,2J1Q9@203682|Planctomycetes	203682|Planctomycetes	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
CMS2_k127_4908926_2	237368.SCABRO_01191	1.277e-243	767.0	COG0369@1|root,COG1151@2|Bacteria,2J2HV@203682|Planctomycetes	2|Bacteria	C	Prismane/CO dehydrogenase family	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
CMS2_k127_4908926_0	247490.KSU1_D0226	5.197e-319	990.0	COG1614@1|root,COG1614@2|Bacteria,2J26P@203682|Planctomycetes	203682|Planctomycetes	C	CO dehydrogenase/acetyl-CoA synthase complex beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhC
CMS2_k127_4908926_4	237368.SCABRO_03345	2.253e-150	487.0	COG1456@1|root,COG1456@2|Bacteria,2J2CN@203682|Planctomycetes	203682|Planctomycetes	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD,FeS
CMS2_k127_4908926_3	247490.KSU1_D0223	3.18e-198	637.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,2J2QB@203682|Planctomycetes	203682|Planctomycetes	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
CMS2_k127_4908926_12	247490.KSU1_D0222	4.865e-60	216.0	COG3640@1|root,COG3640@2|Bacteria,2J1XH@203682|Planctomycetes	203682|Planctomycetes	D	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_4908926_5	247490.KSU1_D0221	1.995e-120	394.0	COG2069@1|root,COG2069@2|Bacteria,2J2KV@203682|Planctomycetes	203682|Planctomycetes	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD
CMS2_k127_4908926_8	237368.SCABRO_03350	3.372e-83	292.0	COG1410@1|root,COG1410@2|Bacteria,2IY5P@203682|Planctomycetes	203682|Planctomycetes	E	Methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
CMS2_k127_493498_0	452637.Oter_1389	1.83e-135	471.0	COG0515@1|root,COG0515@2|Bacteria,46VB0@74201|Verrucomicrobia,3K8AK@414999|Opitutae	414999|Opitutae	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_493498_4	344747.PM8797T_27367	8.864e-61	214.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_493498_16	554065.XP_005849298.1	6.241e-07	59.0	2E2JS@1|root,2S9T4@2759|Eukaryota,3842R@33090|Viridiplantae,34MWH@3041|Chlorophyta	3041|Chlorophyta	K	DNA-binding domain in plant proteins such as APETALA2 and EREBPs	-	-	-	-	-	-	-	-	-	-	-	-	AP2
CMS2_k127_493498_12	1444310.JANV01000096_gene3265	2.749e-09	66.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	DUF4369,Omp28
CMS2_k127_493498_13	400682.PAC_15716390	1.002e-08	68.0	2DZK8@1|root,2S73K@2759|Eukaryota,3AA3U@33154|Opisthokonta,3BU2C@33208|Metazoa	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_493498_17	595460.RRSWK_06756	0.0003866	53.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CW_binding_1,DUF1565,Glyco_hydro_10
CMS2_k127_493498_10	192952.MM_1144	4.049e-16	92.0	COG5563@1|root,arCOG03499@1|root,arCOG03499@2157|Archaea,arCOG03501@2157|Archaea	2157|Archaea	S	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Disaggr_assoc,Disaggr_repeat,PKD
CMS2_k127_493498_14	1121007.AUML01000014_gene2925	1.618e-07	64.0	COG3258@1|root,COG3979@1|root,COG5295@1|root,COG3258@2|Bacteria,COG3979@2|Bacteria,COG5295@2|Bacteria,4NM24@976|Bacteroidetes,1I2FB@117743|Flavobacteriia	976|Bacteroidetes	G	Chitinase class I	-	-	3.2.1.14	ko:K20547	ko00520,ko01100,ko04016,map00520,map01100,map04016	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	CBM18,GH19	-	Glyco_hydro_19
CMS2_k127_493498_7	319224.Sputcn32_0996	1.705e-26	116.0	COG3637@1|root,COG3637@2|Bacteria,1RICQ@1224|Proteobacteria,1SF8S@1236|Gammaproteobacteria,2QBM3@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
CMS2_k127_493498_9	1303518.CCALI_01450	9.103e-19	98.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02679	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_493498_5	1047013.AQSP01000105_gene1458	3.436e-32	132.0	2ERMK@1|root,33J72@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
CMS2_k127_493498_1	794903.OPIT5_24500	1.225e-104	348.0	COG0657@1|root,COG0657@2|Bacteria,46VDF@74201|Verrucomicrobia	74201|Verrucomicrobia	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
CMS2_k127_493498_3	1123371.ATXH01000010_gene706	4.688e-64	236.0	COG2206@1|root,COG2206@2|Bacteria,2GIQV@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,Response_reg
CMS2_k127_493498_2	243231.GSU2766	7.717e-66	231.0	COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,42SVS@68525|delta/epsilon subdivisions,2WNMI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS2_k127_493498_11	1280949.HAD_04000	2.223e-09	60.0	COG3631@1|root,COG3631@2|Bacteria,1N8KG@1224|Proteobacteria,2UH5Z@28211|Alphaproteobacteria,43YCP@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
CMS2_k127_493498_15	1202532.FF52_10433	3.315e-07	56.0	COG3631@1|root,COG3631@2|Bacteria,4NSBA@976|Bacteroidetes,1I5KV@117743|Flavobacteriia,2NZ3X@237|Flavobacterium	976|Bacteroidetes	S	Ketosteroid isomerase-related protein	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
CMS2_k127_493498_8	243365.CV_3977	2.261e-19	96.0	COG3157@1|root,COG3157@2|Bacteria,1RBTU@1224|Proteobacteria,2WEFR@28216|Betaproteobacteria,2KPCB@206351|Neisseriales	206351|Neisseriales	S	Type VI secretion system effector, Hcp	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
CMS2_k127_493498_6	96561.Dole_0858	2.173e-27	118.0	COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,42SES@68525|delta/epsilon subdivisions,2WQ9T@28221|Deltaproteobacteria,2MM24@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative member of DMT superfamily (DUF486)	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
CMS2_k127_4946687_1	189425.PGRAT_24340	8.028e-32	143.0	COG2133@1|root,COG4124@1|root,COG2133@2|Bacteria,COG4124@2|Bacteria,1V0UJ@1239|Firmicutes,4HGW4@91061|Bacilli,26U0Y@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 26 family	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Glyco_hydro_26,PA14
CMS2_k127_4946687_4	459349.CLOAM0895	3.196e-09	70.0	COG1361@1|root,COG1404@1|root,COG4412@1|root,COG1361@2|Bacteria,COG1404@2|Bacteria,COG4412@2|Bacteria,2NREM@2323|unclassified Bacteria	2|Bacteria	O	Evidence 5 No homology to any previously reported sequences	-	-	3.4.17.22	ko:K07752	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Calx-beta,DUF4859,FlgD_ig,VCBS
CMS2_k127_4946687_0	1396141.BATP01000027_gene1160	8.734e-36	156.0	COG2273@1|root,COG2755@1|root,COG3064@1|root,COG3291@1|root,COG5306@1|root,COG2273@2|Bacteria,COG2755@2|Bacteria,COG3064@2|Bacteria,COG3291@2|Bacteria,COG5306@2|Bacteria,46X9M@74201|Verrucomicrobia,2IV4C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EGM	Peptidase M60-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,M60-like_N,PA14,Peptidase_M60
CMS2_k127_4946687_3	1121374.KB891575_gene1561	1.558e-24	113.0	COG3642@1|root,COG3642@2|Bacteria,1NE52@1224|Proteobacteria,1SETQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Lipopolysaccharide kinase (Kdo/WaaP) family	-	-	-	-	-	-	-	-	-	-	-	-	Kdo
CMS2_k127_4946687_2	1177181.T9A_02158	8.49e-29	122.0	COG2365@1|root,COG2365@2|Bacteria,1REIM@1224|Proteobacteria,1S85H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Tyrosine phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Y_phosphatase2,Y_phosphatase3
CMS2_k127_4989381_2	391038.Bphy_7352	4.042e-77	273.0	COG3547@1|root,COG3547@2|Bacteria,1P65H@1224|Proteobacteria,2WEYY@28216|Betaproteobacteria,1KHXJ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS2_k127_4989381_5	502025.Hoch_2959	2.221e-27	116.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,4313Z@68525|delta/epsilon subdivisions,2WX2K@28221|Deltaproteobacteria,2Z2QP@29|Myxococcales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
CMS2_k127_4989381_3	886293.Sinac_4026	2.186e-54	199.0	COG1595@1|root,COG1595@2|Bacteria,2IZ8A@203682|Planctomycetes	203682|Planctomycetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_4989381_1	452637.Oter_1389	6.228e-147	486.0	COG0515@1|root,COG0515@2|Bacteria,46VB0@74201|Verrucomicrobia,3K8AK@414999|Opitutae	414999|Opitutae	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_4989381_6	1182553.XP_007742113.1	1.395e-21	101.0	KOG0295@1|root,KOG0295@2759|Eukaryota,39PAU@33154|Opisthokonta,3Q5NW@4751|Fungi,3RNQX@4890|Ascomycota,20URV@147545|Eurotiomycetes	4751|Fungi	D	Anaphase-promoting complex subunit 4 WD40 domain	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,WD40
CMS2_k127_4989381_4	32057.KB217483_gene10024	7.155e-38	156.0	COG2319@1|root,COG5635@1|root,COG2319@2|Bacteria,COG5635@2|Bacteria,1FZVW@1117|Cyanobacteria,1HMS2@1161|Nostocales	1117|Cyanobacteria	T	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,NACHT,Pentapeptide,WD40
CMS2_k127_4989381_0	1168034.FH5T_18125	7.45e-186	591.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_4989542_1	387631.Asulf_01706	9.714e-52	192.0	COG1814@1|root,arCOG01096@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
CMS2_k127_4989542_0	224324.aq_1922	1.854e-109	363.0	COG1465@1|root,COG1465@2|Bacteria,2G4EK@200783|Aquificae	200783|Aquificae	E	Belongs to the archaeal-type DHQ synthase family	-	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
CMS2_k127_4989542_3	311403.Arad_2396	2.57e-10	70.0	COG0500@1|root,COG2226@2|Bacteria,1MV7N@1224|Proteobacteria,2UEMA@28211|Alphaproteobacteria,4BC9K@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_4989542_2	1267535.KB906767_gene4986	2.089e-13	71.0	COG2382@1|root,COG2382@2|Bacteria,3Y98J@57723|Acidobacteria,2JP52@204432|Acidobacteriia	204432|Acidobacteriia	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	CBM_48,Esterase
CMS2_k127_5023336_4	1210884.HG799462_gene8852	7.763e-62	220.0	28MFE@1|root,2ZASW@2|Bacteria,2J1ME@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
CMS2_k127_5023336_0	595460.RRSWK_02510	6.995e-164	533.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_6,Cellulase
CMS2_k127_5023336_3	243231.GSU0520	8.512e-93	319.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42P4E@68525|delta/epsilon subdivisions,2WN09@28221|Deltaproteobacteria,43SVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
CMS2_k127_5023336_2	886293.Sinac_3436	3.105e-98	327.0	COG3228@1|root,COG3228@2|Bacteria,2IZES@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the MtfA family	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90,SEC-C
CMS2_k127_5023336_1	1168034.FH5T_01595	4.082e-99	338.0	COG1520@1|root,COG1520@2|Bacteria,4P28I@976|Bacteroidetes,2FX0J@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_5023336_5	1237149.C900_05645	1.127e-48	185.0	COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,47UAQ@768503|Cytophagia	976|Bacteroidetes	P	Sodium/calcium exchanger protein	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS2_k127_5036409_4	344747.PM8797T_11234	1.43e-20	99.0	COG2165@1|root,COG2165@2|Bacteria,2J10X@203682|Planctomycetes	203682|Planctomycetes	U	Pfam:N_methyl_2	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_5036409_2	1242864.D187_002582	1.796e-44	166.0	COG1051@1|root,COG1051@2|Bacteria,1QTT4@1224|Proteobacteria,42SX4@68525|delta/epsilon subdivisions,2WPWK@28221|Deltaproteobacteria,2YY1W@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
CMS2_k127_5036409_1	591001.Acfer_1651	3.752e-54	203.0	COG0859@1|root,COG0859@2|Bacteria,1TRN2@1239|Firmicutes,4H25K@909932|Negativicutes	909932|Negativicutes	M	lipopolysaccharide heptosyltransferase	rfaF	-	-	ko:K02841,ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS2_k127_5036409_0	247490.KSU1_C0408	5.74e-299	945.0	COG0060@1|root,COG0060@2|Bacteria,2IWX2@203682|Planctomycetes	203682|Planctomycetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
CMS2_k127_5036409_3	386456.JQKN01000012_gene1062	8.013e-21	98.0	COG0454@1|root,arCOG00844@2157|Archaea	2157|Archaea	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_5060943_1	517418.Ctha_1865	5.306e-50	196.0	COG5184@1|root,COG5492@1|root,COG5184@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,CHU_C,Calx-beta,ChW,Flg_new,Glug,Phage_TTP_12,RCC1
CMS2_k127_5060943_2	290317.Cpha266_0061	4.008e-09	63.0	2BYAC@1|root,32R5Y@2|Bacteria,1FF3I@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5060943_0	330214.NIDE2498	1.268e-237	744.0	COG2333@1|root,COG2333@2|Bacteria	2|Bacteria	N	competence protein COMEC	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	CW_binding_1,Lactamase_B
CMS2_k127_5060943_3	234267.Acid_1496	1.99e-08	61.0	COG1974@1|root,COG1974@2|Bacteria,3Y47Z@57723|Acidobacteria	57723|Acidobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
CMS2_k127_5082263_0	518766.Rmar_1459	6.683e-162	524.0	COG0017@1|root,COG0017@2|Bacteria,4NDY4@976|Bacteroidetes,1FIMN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	tRNA synthetases class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
CMS2_k127_5082263_9	1183438.GKIL_1583	1.212e-22	115.0	COG1413@1|root,COG4219@1|root,COG1413@2|Bacteria,COG4219@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,PT-HINT,Peptidase_M56,Sulfatase
CMS2_k127_5082263_10	1267535.KB906767_gene430	1.266e-21	98.0	COG3682@1|root,COG3682@2|Bacteria,3Y8B7@57723|Acidobacteria	57723|Acidobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS2_k127_5082263_15	1122146.AUHP01000011_gene291	8.39e-06	48.0	COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,4H9YH@91061|Bacilli,3F4EK@33958|Lactobacillaceae	91061|Bacilli	J	Asparaginyl-tRNA synthetase	asnS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
CMS2_k127_5082263_11	1303518.CCALI_02308	2.757e-16	89.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02679	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_5082263_6	497964.CfE428DRAFT_1649	2.26e-34	147.0	COG3506@1|root,COG4254@1|root,COG3506@2|Bacteria,COG4254@2|Bacteria,46SQ1@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Lyase_8,Lyase_N,Lyase_catalyt
CMS2_k127_5082263_14	1384049.CD29_05330	2.055e-08	60.0	COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,4H9YH@91061|Bacilli,3IWNK@400634|Lysinibacillus	91061|Bacilli	J	Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA	asnS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
CMS2_k127_5082263_5	1123508.JH636439_gene1115	4.295e-55	214.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_5082263_1	1380394.JADL01000001_gene3011	1.392e-71	253.0	COG2045@1|root,COG2045@2|Bacteria,1N3KG@1224|Proteobacteria,2UR25@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	2-phosphosulpholactate phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	2-ph_phosp
CMS2_k127_5082263_2	644282.Deba_0738	2.575e-69	245.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WNH0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
CMS2_k127_5082263_12	247490.KSU1_C0312	4.478e-14	81.0	COG0542@1|root,COG0542@2|Bacteria,2IXHI@203682|Planctomycetes	203682|Planctomycetes	O	with chaperone activity ATP-binding	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
CMS2_k127_5082263_4	595460.RRSWK_03066	2.07e-58	207.0	COG0503@1|root,COG0503@2|Bacteria,2IZ9H@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
CMS2_k127_5082263_3	344747.PM8797T_32290	5.019e-65	235.0	COG0568@1|root,COG0568@2|Bacteria,2IYCB@203682|Planctomycetes	203682|Planctomycetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS2_k127_5082263_8	1122609.AUGT01000008_gene2868	5.42e-31	143.0	COG0366@1|root,COG0515@1|root,COG2133@1|root,COG3227@1|root,COG4733@1|root,COG0366@2|Bacteria,COG0515@2|Bacteria,COG2133@2|Bacteria,COG3227@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.3	ko:K01178,ko:K14645,ko:K18546	ko00500,ko01100,ko02024,map00500,map01100,map02024	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH15	-	Alpha-amylase,GSDH,He_PIG,PKD,Pro_Al_protease,SLH,Trypsin,fn3
CMS2_k127_5082263_13	485917.Phep_2792	5.149e-10	74.0	COG3866@1|root,COG3866@2|Bacteria,4NJUK@976|Bacteroidetes	976|Bacteroidetes	G	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5082263_7	1396141.BATP01000027_gene1160	1.231e-33	151.0	COG2273@1|root,COG2755@1|root,COG3064@1|root,COG3291@1|root,COG5306@1|root,COG2273@2|Bacteria,COG2755@2|Bacteria,COG3064@2|Bacteria,COG3291@2|Bacteria,COG5306@2|Bacteria,46X9M@74201|Verrucomicrobia,2IV4C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EGM	Peptidase M60-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,M60-like_N,PA14,Peptidase_M60
CMS2_k127_5084580_13	604354.TSIB_0372	2.599e-16	91.0	COG2407@1|root,arCOG01772@2157|Archaea,2Y2JG@28890|Euryarchaeota,243J3@183968|Thermococci	183968|Thermococci	G	L-fucose isomerase and related	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5084580_9	1303518.CCALI_01913	8.817e-41	160.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02679	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_5084580_0	1519464.HY22_02080	4.939e-225	713.0	COG0449@1|root,COG0449@2|Bacteria,1FDCR@1090|Chlorobi	1090|Chlorobi	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
CMS2_k127_5084580_7	760568.Desku_1690	7.544e-52	190.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,260M0@186807|Peptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
CMS2_k127_5084580_2	1121468.AUBR01000017_gene2365	6.96e-99	329.0	COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,42FAR@68295|Thermoanaerobacterales	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05755	His_biosynth
CMS2_k127_5084580_5	160799.PBOR_11910	5.758e-65	244.0	COG0793@1|root,COG0793@2|Bacteria,1V2B2@1239|Firmicutes,4IBHM@91061|Bacilli,270GY@186822|Paenibacillaceae	91061|Bacilli	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
CMS2_k127_5084580_10	497964.CfE428DRAFT_5014	1.428e-28	134.0	COG2304@1|root,COG3055@1|root,COG3119@1|root,COG3291@1|root,COG2304@2|Bacteria,COG3055@2|Bacteria,COG3119@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	rapB1	-	3.2.1.4	ko:K01179,ko:K07004,ko:K12548	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Laminin_G_3
CMS2_k127_5084580_16	661478.OP10G_4722	4.404e-10	74.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
CMS2_k127_5084580_17	78398.KS43_05645	3.821e-06	57.0	COG3712@1|root,COG3712@2|Bacteria,1N28G@1224|Proteobacteria,1RR9M@1236|Gammaproteobacteria,1MSYY@122277|Pectobacterium	1236|Gammaproteobacteria	PT	FecR protein	fecR	-	-	ko:K07165	-	-	-	-	ko00000	-	-	-	DUF4880,DUF4974,FecR
CMS2_k127_5084580_19	479435.Kfla_3917	0.0004125	51.0	COG5662@1|root,COG5662@2|Bacteria,2GNCC@201174|Actinobacteria,4DSI4@85009|Propionibacteriales	201174|Actinobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
CMS2_k127_5084580_11	1499967.BAYZ01000081_gene1047	1.278e-20	101.0	COG1595@1|root,COG1595@2|Bacteria,2NPR9@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_5084580_6	595460.RRSWK_03118	6.92e-59	216.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_5084580_14	1227261.HMPREF0043_00275	6.308e-15	90.0	COG2314@1|root,COG2314@2|Bacteria	2|Bacteria	J	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
CMS2_k127_5084580_4	595460.RRSWK_03120	4.245e-94	344.0	COG0515@1|root,COG0515@2|Bacteria,2IYAA@203682|Planctomycetes	203682|Planctomycetes	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_5084580_12	886293.Sinac_3817	7.04e-19	101.0	COG1716@1|root,COG1716@2|Bacteria,2IZA4@203682|Planctomycetes	203682|Planctomycetes	T	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	FHA
CMS2_k127_5084580_1	1168034.FH5T_03280	2.103e-157	529.0	COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	dppX	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
CMS2_k127_5084580_15	1382359.JIAL01000001_gene1441	5.093e-12	80.0	COG0457@1|root,COG0457@2|Bacteria,3Y3EM@57723|Acidobacteria,2JIDA@204432|Acidobacteriia	204432|Acidobacteriia	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TPR_11,TPR_16,TPR_2,TPR_8
CMS2_k127_5084580_3	192952.MM_1582	1.226e-94	312.0	COG0655@1|root,arCOG02573@2157|Archaea,2XWPJ@28890|Euryarchaeota,2NAHI@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS2_k127_5110124_3	1288963.ADIS_1567	3.122e-83	287.0	COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,47K1Z@768503|Cytophagia	976|Bacteroidetes	P	Sodium/calcium exchanger protein	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS2_k127_5110124_2	1237149.C900_05645	1.409e-89	306.0	COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,47UAQ@768503|Cytophagia	976|Bacteroidetes	P	Sodium/calcium exchanger protein	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS2_k127_5110124_5	1117943.SFHH103_00207	5.937e-08	54.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2U99Y@28211|Alphaproteobacteria,4BETQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
CMS2_k127_5110124_4	1121439.dsat_1833	2.018e-22	102.0	2EEAU@1|root,33859@2|Bacteria,1NPX9@1224|Proteobacteria,4367D@68525|delta/epsilon subdivisions,2X0RQ@28221|Deltaproteobacteria,2MD7Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5110124_1	247490.KSU1_C0383	4.633e-90	312.0	COG4487@1|root,COG4487@2|Bacteria,2J16Y@203682|Planctomycetes	203682|Planctomycetes	I	mechanosensitive ion channel activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2130
CMS2_k127_5110124_0	661478.OP10G_0633	7.448e-265	824.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
CMS2_k127_5110124_6	1121930.AQXG01000010_gene3085	6.463e-05	54.0	COG1913@1|root,COG1913@2|Bacteria,4NJFJ@976|Bacteroidetes	976|Bacteroidetes	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_5
CMS2_k127_5112716_11	1168034.FH5T_09895	4.608e-18	87.0	COG0584@1|root,COG0584@2|Bacteria,4NMGN@976|Bacteroidetes,2FP5M@200643|Bacteroidia	976|Bacteroidetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS2_k127_5112716_13	339860.Msp_0544	0.0003323	54.0	COG1409@1|root,arCOG01153@2157|Archaea,2XWZF@28890|Euryarchaeota,23NZ7@183925|Methanobacteria	183925|Methanobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
CMS2_k127_5112716_1	1267535.KB906767_gene4234	4.573e-157	512.0	COG0673@1|root,COG0673@2|Bacteria,3Y6RB@57723|Acidobacteria,2JKWU@204432|Acidobacteriia	204432|Acidobacteriia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5112716_12	484018.BACPLE_01426	1.067e-17	97.0	COG2407@1|root,COG2407@2|Bacteria,4P1BT@976|Bacteroidetes,2FMIE@200643|Bacteroidia,4AKFB@815|Bacteroidaceae	976|Bacteroidetes	G	COG2407 L-fucose isomerase and related	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5112716_0	314230.DSM3645_18261	1.645e-159	518.0	COG1520@1|root,COG1520@2|Bacteria,2IXD2@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS2_k127_5112716_7	1278073.MYSTI_02610	1.234e-55	224.0	COG4886@1|root,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	-	-	-	-	-	-	-	-	-	-	LRR_6
CMS2_k127_5112716_8	649638.Trad_0281	6.695e-26	126.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56,TonB_C
CMS2_k127_5112716_10	1192034.CAP_3244	3.362e-18	89.0	COG3682@1|root,COG3682@2|Bacteria,1RKDI@1224|Proteobacteria,4383A@68525|delta/epsilon subdivisions,2X3DA@28221|Deltaproteobacteria,2YVI8@29|Myxococcales	28221|Deltaproteobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS2_k127_5112716_4	344747.PM8797T_26405	3.556e-102	349.0	COG0673@1|root,COG0673@2|Bacteria,2IWX9@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5112716_6	314230.DSM3645_14090	4.115e-85	295.0	COG1413@1|root,COG3828@1|root,COG1413@2|Bacteria,COG3828@2|Bacteria,2IX8S@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_5112716_3	452637.Oter_3509	1.959e-103	352.0	COG0673@1|root,COG0673@2|Bacteria,46TMZ@74201|Verrucomicrobia,3K8Y2@414999|Opitutae	414999|Opitutae	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5112716_5	1408473.JHXO01000001_gene1962	1.886e-96	327.0	COG0667@1|root,COG0667@2|Bacteria,4PPAM@976|Bacteroidetes,2G14T@200643|Bacteroidia	976|Bacteroidetes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS2_k127_5112716_2	682795.AciX8_3506	8.676e-154	504.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,Cellulase,Glyco_hydro_2_C,Glyco_hydro_42,Glycos_transf_2
CMS2_k127_5112842_0	583355.Caka_1736	6.308e-129	430.0	COG2312@1|root,COG2312@2|Bacteria,46TMX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH,LTD
CMS2_k127_5112842_1	517722.AEUE01000010_gene532	4.674e-07	63.0	COG3468@1|root,COG4412@1|root,COG3468@2|Bacteria,COG4412@2|Bacteria,1MVQ6@1224|Proteobacteria,2UAUP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	MU	Outer membrane autotransporter	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Calx-beta
CMS2_k127_5123833_4	869213.JCM21142_72957	2.621e-34	137.0	2A42S@1|root,30SMP@2|Bacteria,4P40W@976|Bacteroidetes	976|Bacteroidetes	S	Nickel-containing superoxide dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Sod_Ni
CMS2_k127_5123833_2	1267535.KB906767_gene511	5.171e-169	548.0	COG3669@1|root,COG3669@2|Bacteria,3Y3J6@57723|Acidobacteria,2JKNJ@204432|Acidobacteriia	204432|Acidobacteriia	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
CMS2_k127_5123833_0	891968.Anamo_0058	0.0	1420.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,3T9XS@508458|Synergistetes	508458|Synergistetes	I	enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
CMS2_k127_5123833_3	1142394.PSMK_03840	5.305e-87	301.0	COG0592@1|root,COG0592@2|Bacteria,2IY9S@203682|Planctomycetes	203682|Planctomycetes	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
CMS2_k127_5123833_1	338966.Ppro_0004	2.165e-226	727.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,43U22@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
CMS2_k127_5135654_0	1123508.JH636442_gene4219	2.261e-283	898.0	COG2373@1|root,COG2373@2|Bacteria,2IWRT@203682|Planctomycetes	203682|Planctomycetes	S	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl
CMS2_k127_5135654_4	335541.Swol_1076	8.836e-87	313.0	COG5492@1|root,COG5492@2|Bacteria,1V7TS@1239|Firmicutes,25F4B@186801|Clostridia,42KX4@68298|Syntrophomonadaceae	2|Bacteria	N	Surface proteins containing Ig-like domains-like	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CBM_X2,CHB_HEX_C_1,Flg_new,Glug,SLH
CMS2_k127_5135654_1	886293.Sinac_6463	8.745e-271	849.0	COG0480@1|root,COG0480@2|Bacteria,2IXUD@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS2_k127_5135654_3	1218074.BAXZ01000005_gene1436	2.972e-123	407.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K3N3@119060|Burkholderiaceae	28216|Betaproteobacteria	JKL	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlE	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
CMS2_k127_5135654_2	946483.Cenrod_1917	1.353e-214	679.0	COG0425@1|root,COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0425@2|Bacteria,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1NR3M@1224|Proteobacteria,2VJSV@28216|Betaproteobacteria,4AAZZ@80864|Comamonadaceae	28216|Betaproteobacteria	O	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Reductase_C,Rieske
CMS2_k127_5149231_5	1122915.AUGY01000004_gene5579	4.772e-56	215.0	COG3507@1|root,COG3507@2|Bacteria,1U0J7@1239|Firmicutes,4I9Y3@91061|Bacilli,2724D@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
CMS2_k127_5149231_1	756272.Plabr_3753	8.782e-206	660.0	COG3119@1|root,COG3119@2|Bacteria,2J2K4@203682|Planctomycetes	203682|Planctomycetes	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS2_k127_5149231_2	886293.Sinac_2390	1.195e-186	602.0	COG3119@1|root,COG3119@2|Bacteria,2IYRK@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_5149231_0	1396418.BATQ01000182_gene934	2.208e-210	662.0	COG3119@1|root,COG3119@2|Bacteria,46U02@74201|Verrucomicrobia,2ITYT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_5149231_3	313628.LNTAR_07274	7.223e-153	501.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_5149231_4	1123242.JH636434_gene3707	8.647e-90	311.0	COG1519@1|root,COG1519@2|Bacteria,2IYCJ@203682|Planctomycetes	203682|Planctomycetes	M	transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
CMS2_k127_5155971_7	1265503.KB905160_gene2810	1.064e-135	440.0	COG3669@1|root,COG3669@2|Bacteria,1N8B5@1224|Proteobacteria,1RWUY@1236|Gammaproteobacteria,2Q842@267889|Colwelliaceae	1236|Gammaproteobacteria	G	Alpha-L-fucosidase	fucA1	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Fucosidase_C
CMS2_k127_5155971_3	313628.LNTAR_17398	4.767e-180	576.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_5155971_6	313628.LNTAR_17388	5.581e-137	454.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_5155971_4	886293.Sinac_7118	1.738e-176	567.0	COG3119@1|root,COG3119@2|Bacteria,2IXIE@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
CMS2_k127_5155971_0	391598.FBBAL38_11614	6.968e-250	786.0	2EXY1@1|root,33R74@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_42
CMS2_k127_5155971_5	313628.LNTAR_16528	6.012e-157	512.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	atsA_1	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_5155971_8	886293.Sinac_0924	4.937e-119	407.0	COG3119@1|root,COG3119@2|Bacteria,2IWX1@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.8	ko:K01134	ko00600,ko04142,map00600,map04142	-	R04856	RC00231	ko00000,ko00001,ko01000	-	-	-	DUF4994,Sulfatase
CMS2_k127_5155971_1	1121859.KB890750_gene214	1.106e-229	721.0	COG3119@1|root,COG3119@2|Bacteria,4NE9D@976|Bacteroidetes,47TZN@768503|Cytophagia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_5155971_2	313628.LNTAR_00440	3.066e-188	601.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_5155971_9	595460.RRSWK_03845	2.46e-45	166.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
CMS2_k127_5171280_0	1122609.AUGT01000008_gene2868	6.204e-47	195.0	COG0366@1|root,COG0515@1|root,COG2133@1|root,COG3227@1|root,COG4733@1|root,COG0366@2|Bacteria,COG0515@2|Bacteria,COG2133@2|Bacteria,COG3227@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.3	ko:K01178,ko:K14645,ko:K18546	ko00500,ko01100,ko02024,map00500,map01100,map02024	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH15	-	Alpha-amylase,GSDH,He_PIG,PKD,Pro_Al_protease,SLH,Trypsin,fn3
CMS2_k127_5174002_11	1047013.AQSP01000076_gene1470	5.053e-55	197.0	COG3385@1|root,COG3385@2|Bacteria,2NRDU@2323|unclassified Bacteria	2|Bacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
CMS2_k127_5174002_14	1123053.AUDG01000057_gene3267	1.347e-34	143.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1WWU7@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
CMS2_k127_5174002_19	240016.ABIZ01000001_gene244	1.497e-15	77.0	COG4409@1|root,COG4409@2|Bacteria,46T16@74201|Verrucomicrobia	74201|Verrucomicrobia	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
CMS2_k127_5174002_6	886293.Sinac_6953	4.297e-100	342.0	COG5434@1|root,COG5434@2|Bacteria,2IX4K@203682|Planctomycetes	203682|Planctomycetes	M	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_5174002_13	215803.DB30_0449	9.467e-35	141.0	COG1994@1|root,COG1994@2|Bacteria,1N531@1224|Proteobacteria,43AZN@68525|delta/epsilon subdivisions,2X6DV@28221|Deltaproteobacteria,2YVCV@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
CMS2_k127_5174002_5	452637.Oter_2975	9.613e-130	428.0	COG0673@1|root,COG0673@2|Bacteria,46UJ9@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5174002_7	452637.Oter_2976	2.454e-87	299.0	COG3622@1|root,COG3622@2|Bacteria,46TIJ@74201|Verrucomicrobia,3K80T@414999|Opitutae	414999|Opitutae	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
CMS2_k127_5174002_0	886293.Sinac_5717	3.035e-269	839.0	COG3119@1|root,COG3119@2|Bacteria,2IXWN@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_5174002_3	344747.PM8797T_31558	6.303e-145	467.0	COG1073@1|root,COG1073@2|Bacteria,2J2QA@203682|Planctomycetes	203682|Planctomycetes	S	Abhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_7
CMS2_k127_5174002_10	1313304.CALK_2318	4.341e-61	221.0	COG1262@1|root,COG4870@1|root,COG1262@2|Bacteria,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,Peptidase_C1,Trypsin_2
CMS2_k127_5174002_12	32057.KB217478_gene508	1.899e-47	187.0	COG1451@1|root,COG1451@2|Bacteria,1G5F8@1117|Cyanobacteria,1HRV4@1161|Nostocales	1117|Cyanobacteria	S	nucleotide metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	SprT-like
CMS2_k127_5174002_8	639030.JHVA01000001_gene1796	6.566e-82	298.0	COG5360@1|root,COG5360@2|Bacteria	2|Bacteria	S	Heparinase II/III-like protein	-	-	4.2.2.26	ko:K20525	-	-	-	-	ko00000,ko01000	-	-	-	Alginate_lyase,Hepar_II_III,Hepar_II_III_N
CMS2_k127_5174002_4	1121403.AUCV01000007_gene1231	4.53e-136	443.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,42NHC@68525|delta/epsilon subdivisions,2WJQJ@28221|Deltaproteobacteria,2MJKV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Alanine dehydrogenase/PNT, C-terminal domain	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
CMS2_k127_5174002_15	382464.ABSI01000014_gene1434	2.327e-31	128.0	COG3288@1|root,COG3288@2|Bacteria,46T7S@74201|Verrucomicrobia	74201|Verrucomicrobia	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
CMS2_k127_5174002_2	382464.ABSI01000014_gene1435	6.593e-152	495.0	COG1282@1|root,COG1282@2|Bacteria,46SBC@74201|Verrucomicrobia	74201|Verrucomicrobia	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
CMS2_k127_5174002_18	518766.Rmar_1484	1.504e-18	101.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,Kelch_4
CMS2_k127_5174002_9	1396141.BATP01000062_gene4458	3.46e-63	245.0	COG1082@1|root,COG2730@1|root,COG3119@1|root,COG3250@1|root,COG3533@1|root,COG4733@1|root,COG5297@1|root,COG1082@2|Bacteria,COG2730@2|Bacteria,COG3119@2|Bacteria,COG3250@2|Bacteria,COG3533@2|Bacteria,COG4733@2|Bacteria,COG5297@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase family 6	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	AP_endonuc_2,Alginate_lyase,Laminin_G_3,NPCBM
CMS2_k127_5174002_21	1123322.KB904669_gene3662	8.007e-09	69.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS2_k127_5174002_17	1292035.H476_3569	5.873e-20	95.0	COG3227@1|root,COG4886@1|root,COG3227@2|Bacteria,COG4886@2|Bacteria,1V3UH@1239|Firmicutes,24K2H@186801|Clostridia,25TYN@186804|Peptostreptococcaceae	186801|Clostridia	E	Leucine Rich repeats (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3888,FIVAR,LRR_4
CMS2_k127_5174002_16	370438.PTH_2805	1.38e-23	107.0	COG4886@1|root,COG4886@2|Bacteria,1V3UH@1239|Firmicutes,24K2H@186801|Clostridia	186801|Clostridia	E	leucine-rich repeat-containing protein typical subtype	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_4,DUF5050,LRR_4
CMS2_k127_5174002_1	886293.Sinac_6937	4.368e-199	631.0	COG0673@1|root,COG0673@2|Bacteria,2IXJ0@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5174002_22	1123242.JH636434_gene5202	1.123e-05	50.0	COG1943@1|root,COG1943@2|Bacteria,2IYXS@203682|Planctomycetes	203682|Planctomycetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
CMS2_k127_5180607_3	497964.CfE428DRAFT_3662	3.787e-107	356.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
CMS2_k127_5180607_10	269482.Bcep1808_6108	1.337e-05	54.0	2A88X@1|root,30XA3@2|Bacteria,1PJ4P@1224|Proteobacteria,2W7PX@28216|Betaproteobacteria,1KEXW@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5180607_6	365044.Pnap_2179	2.119e-57	213.0	COG3212@1|root,COG3212@2|Bacteria,1N0D3@1224|Proteobacteria	1224|Proteobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
CMS2_k127_5180607_5	1121324.CLIT_2c03230	6.532e-62	222.0	COG2998@1|root,COG2998@2|Bacteria,1V9V8@1239|Firmicutes,25H3U@186801|Clostridia	186801|Clostridia	H	Copper amine oxidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1
CMS2_k127_5180607_4	1396141.BATP01000039_gene1286	2.57e-69	244.0	COG0745@1|root,COG0745@2|Bacteria,46YWV@74201|Verrucomicrobia,2IVQX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_5180607_7	497964.CfE428DRAFT_4890	1.596e-53	207.0	COG0642@1|root,COG2205@2|Bacteria	497964.CfE428DRAFT_4890|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5180607_1	1511.CLOST_0922	3.812e-136	445.0	COG0205@1|root,COG0205@2|Bacteria,1TRJQ@1239|Firmicutes,247IV@186801|Clostridia	186801|Clostridia	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
CMS2_k127_5180607_8	1123393.KB891316_gene1263	5.315e-51	188.0	293J8@1|root,2ZR19@2|Bacteria,1R6Y4@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5180607_9	1121100.JCM6294_1674	3.044e-08	65.0	COG1409@1|root,COG1520@1|root,COG1409@2|Bacteria,COG1520@2|Bacteria,4NFA9@976|Bacteroidetes,2FPAX@200643|Bacteroidia,4AKXI@815|Bacteroidaceae	976|Bacteroidetes	M	PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,PQQ_2,PQQ_3
CMS2_k127_5180607_0	1137799.GZ78_16455	8.39e-165	530.0	COG3977@1|root,COG3977@2|Bacteria,1MVRW@1224|Proteobacteria,1RNK1@1236|Gammaproteobacteria,1XHID@135619|Oceanospirillales	135619|Oceanospirillales	E	catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids	avtA	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS2_k127_5180607_2	635013.TherJR_1006	3.934e-135	468.0	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,2606F@186807|Peptococcaceae	186801|Clostridia	L	ATP-dependent helicase nuclease subunit A	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
CMS2_k127_5206972_3	909663.KI867150_gene970	4.027e-109	365.0	COG4191@1|root,COG4191@2|Bacteria,1R89N@1224|Proteobacteria,42QDX@68525|delta/epsilon subdivisions,2WKNA@28221|Deltaproteobacteria,2MR83@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS
CMS2_k127_5206972_2	909663.KI867150_gene971	7.799e-176	561.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2X1VS@28221|Deltaproteobacteria,2MRES@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_5206972_7	335543.Sfum_2441	6.245e-14	77.0	299YV@1|root,2ZX0J@2|Bacteria,1P75H@1224|Proteobacteria,432SS@68525|delta/epsilon subdivisions,2WY0Q@28221|Deltaproteobacteria,2MSEU@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5206972_6	1047013.AQSP01000091_gene641	7.545e-45	174.0	COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS2_k127_5206972_0	1047013.AQSP01000091_gene642	0.0	1080.0	COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	sfrB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0055114,GO:0071944	1.12.1.3,1.17.1.10,1.6.5.3	ko:K00335,ko:K15022,ko:K18331	ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00134,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
CMS2_k127_5206972_4	1047013.AQSP01000091_gene643	5.904e-77	265.0	COG3383@1|root,COG3383@2|Bacteria,2NNXH@2323|unclassified Bacteria	2|Bacteria	C	Iron hydrogenase small subunit	-	-	1.12.1.3,1.17.1.9,1.6.5.3	ko:K00123,ko:K00336,ko:K18332	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iHN637.CLJU_RS03470	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_21,Fer4_7,NADH-G_4Fe-4S_3
CMS2_k127_5206972_1	1047013.AQSP01000091_gene644	1.058e-242	759.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	yahG	-	-	-	-	-	-	-	-	-	-	-	DUF1116,FMN_dh,Glu_synthase
CMS2_k127_5206972_5	1123242.JH636434_gene3841	2.829e-45	168.0	COG1484@1|root,COG1484@2|Bacteria,2J3U3@203682|Planctomycetes	203682|Planctomycetes	L	PFAM IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
CMS2_k127_523658_1	1144275.COCOR_07912	3.477e-05	54.0	COG4932@1|root,COG4932@2|Bacteria,1R5S8@1224|Proteobacteria	1224|Proteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS2_k127_523658_0	1278073.MYSTI_04884	2.451e-14	87.0	COG3485@1|root,COG3485@2|Bacteria,1QXUR@1224|Proteobacteria,43C7D@68525|delta/epsilon subdivisions,2X7HP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS2_k127_5241231_15	869213.JCM21142_72658	3.552e-40	153.0	COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,47NH0@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5241231_13	1396141.BATP01000002_gene4837	7.694e-61	231.0	COG3828@1|root,COG3828@2|Bacteria,46V1D@74201|Verrucomicrobia,2IUS0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
CMS2_k127_5241231_18	1403819.BATR01000007_gene210	1.813e-14	87.0	COG0515@1|root,COG0515@2|Bacteria,46TX9@74201|Verrucomicrobia,2ITZK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,Pkinase
CMS2_k127_5241231_19	661478.OP10G_2205	2.063e-12	80.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179,ko:K13276	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH5,GH9	-	Cellulase,F5_F8_type_C,FIVAR
CMS2_k127_5241231_17	661478.OP10G_2205	6.449e-18	98.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179,ko:K13276	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH5,GH9	-	Cellulase,F5_F8_type_C,FIVAR
CMS2_k127_5241231_14	1396141.BATP01000023_gene671	3.877e-56	216.0	COG2010@1|root,COG2010@2|Bacteria,46TRF@74201|Verrucomicrobia,2IVAI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_5241231_8	756272.Plabr_3539	1.421e-88	310.0	COG0673@1|root,COG0673@2|Bacteria,2IX6I@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5241231_1	1396418.BATQ01000017_gene4177	2.02e-172	554.0	COG0673@1|root,COG0673@2|Bacteria,46U95@74201|Verrucomicrobia,2IVCR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_5241231_0	1396418.BATQ01000017_gene4177	7.388e-173	556.0	COG0673@1|root,COG0673@2|Bacteria,46U95@74201|Verrucomicrobia,2IVCR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_5241231_2	518766.Rmar_1740	5.292e-162	522.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,1FK20@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5241231_4	452637.Oter_2196	4.167e-144	470.0	COG0673@1|root,COG0673@2|Bacteria,46U95@74201|Verrucomicrobia,3K969@414999|Opitutae	414999|Opitutae	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5241231_5	452637.Oter_2196	6.055e-142	464.0	COG0673@1|root,COG0673@2|Bacteria,46U95@74201|Verrucomicrobia,3K969@414999|Opitutae	414999|Opitutae	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5241231_3	518766.Rmar_1740	8.149e-147	479.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,1FK20@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5241231_6	518766.Rmar_1740	9.892e-142	462.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,1FK20@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5241231_11	641524.ADICYQ_5412	5.451e-74	267.0	COG1082@1|root,COG1082@2|Bacteria,4NJJZ@976|Bacteroidetes,47PI6@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_5241231_16	497964.CfE428DRAFT_4716	1.803e-36	155.0	2DDUH@1|root,2ZJBH@2|Bacteria	2|Bacteria	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_5241231_12	497964.CfE428DRAFT_6475	3.057e-64	238.0	COG2133@1|root,COG2133@2|Bacteria,46UM9@74201|Verrucomicrobia	2|Bacteria	G	Domain of Unknown Function (DUF1080)	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Calx-beta,DUF1080,F5_F8_type_C
CMS2_k127_5241231_9	1403819.BATR01000090_gene2633	5.207e-79	281.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Calx-beta,DUF1080,F5_F8_type_C,PA14
CMS2_k127_5241231_7	452637.Oter_3513	2.107e-135	445.0	COG0673@1|root,COG0673@2|Bacteria,46ZKA@74201|Verrucomicrobia,3K93V@414999|Opitutae	414999|Opitutae	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5241231_10	243090.RB4846	1.065e-77	277.0	COG2864@1|root,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
CMS2_k127_5251038_7	1210884.HG799465_gene12083	1.4e-29	122.0	COG2706@1|root,COG2706@2|Bacteria,2IY02@203682|Planctomycetes	203682|Planctomycetes	G	COG2706 3-carboxymuconate cyclase	-	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
CMS2_k127_5251038_0	621372.ACIH01000162_gene3468	1.708e-199	644.0	COG3533@1|root,COG3533@2|Bacteria,1TRI1@1239|Firmicutes,4HETR@91061|Bacilli,26TRB@186822|Paenibacillaceae	91061|Bacilli	S	Beta-L-arabinofuranosidase, GH127	M1-419	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Big_4,Cadherin-like,DUF4986,Glyco_hydro_127
CMS2_k127_5251038_6	234267.Acid_6615	1.075e-61	229.0	28KX8@1|root,2ZAD8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5251038_3	56780.SYN_01159	7.981e-127	415.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WMDC@28221|Deltaproteobacteria,2MREJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Alcohol dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS2_k127_5251038_1	143224.JQMD01000002_gene281	9.087e-187	598.0	COG0591@1|root,COG0591@2|Bacteria,4NEN8@976|Bacteroidetes,1HYVB@117743|Flavobacteriia	976|Bacteroidetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_5251038_2	497964.CfE428DRAFT_4153	2.178e-129	422.0	COG0329@1|root,COG0329@2|Bacteria,46UU4@74201|Verrucomicrobia	74201|Verrucomicrobia	EM	Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CMS2_k127_5251038_4	1267535.KB906767_gene1681	1.289e-90	315.0	COG0399@1|root,COG0399@2|Bacteria,3Y7K8@57723|Acidobacteria,2JK8Z@204432|Acidobacteriia	57723|Acidobacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_5251038_5	886293.Sinac_5445	9.271e-71	244.0	COG0515@1|root,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,TPR_8,WD40
CMS2_k127_5261151_11	237368.SCABRO_00237	1.072e-05	57.0	2DS24@1|root,33E6B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5261151_6	575540.Isop_2745	4.926e-73	270.0	COG2304@1|root,COG2304@2|Bacteria,2IXP0@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
CMS2_k127_5261151_4	886293.Sinac_2614	5.823e-83	287.0	COG1721@1|root,COG1721@2|Bacteria,2IY59@203682|Planctomycetes	203682|Planctomycetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS2_k127_5261151_2	1499967.BAYZ01000095_gene4253	2.797e-115	381.0	COG0714@1|root,COG0714@2|Bacteria,2NNV8@2323|unclassified Bacteria	2|Bacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS2_k127_5261151_1	886293.Sinac_2617	9.351e-149	510.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,2IXKI@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like,VWA,VWA_3
CMS2_k127_5261151_8	886293.Sinac_2618	3.069e-63	245.0	COG3391@1|root,COG3391@2|Bacteria,2IYRP@203682|Planctomycetes	203682|Planctomycetes	P	RING finger protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,NHL
CMS2_k127_5261151_12	485913.Krac_1284	0.0001284	55.0	COG1175@1|root,COG1175@2|Bacteria,2G8DB@200795|Chloroflexi	2|Bacteria	G	COGs COG1175 ABC-type sugar transport systems permease components	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
CMS2_k127_5261151_7	765912.Thimo_1760	1.131e-72	261.0	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,1RQ6Z@1236|Gammaproteobacteria,1WWM0@135613|Chromatiales	135613|Chromatiales	P	extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
CMS2_k127_5261151_9	530564.Psta_2032	2.314e-17	96.0	COG1196@1|root,COG1196@2|Bacteria,2IYM0@203682|Planctomycetes	203682|Planctomycetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5261151_3	530564.Psta_2420	2.656e-103	354.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_5261151_5	1123242.JH636434_gene5127	2.322e-81	282.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_NS,NHL
CMS2_k127_5261151_10	941449.dsx2_0928	3.373e-06	51.0	COG1225@1|root,COG1225@2|Bacteria,1N9JS@1224|Proteobacteria,42R82@68525|delta/epsilon subdivisions,2WMVA@28221|Deltaproteobacteria,2MBM6@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
CMS2_k127_5261151_0	1168034.FH5T_18780	4.184e-199	631.0	COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes,2FQ3G@200643|Bacteroidia	976|Bacteroidetes	P	Arylsulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
CMS2_k127_527271_1	1195236.CTER_1105	5.755e-82	288.0	COG3250@1|root,COG3250@2|Bacteria,1VSYK@1239|Firmicutes,24D78@186801|Clostridia,3WSA4@541000|Ruminococcaceae	2|Bacteria	G	Glycosyl hydrolases family 2, TIM barrel domain	-	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C
CMS2_k127_527271_3	794903.OPIT5_13005	3.124e-19	96.0	COG2165@1|root,COG2165@2|Bacteria,46Z5T@74201|Verrucomicrobia,3K9RI@414999|Opitutae	414999|Opitutae	U	Protein of unknown function (DUF1559)	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_527271_2	285535.JOEY01000008_gene8762	1.376e-51	201.0	COG1053@1|root,COG1053@2|Bacteria,2HD4N@201174|Actinobacteria	201174|Actinobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
CMS2_k127_527271_0	1123277.KB893176_gene3707	3.308e-253	808.0	COG2173@1|root,COG2173@2|Bacteria	2|Bacteria	M	zinc D-Ala-D-Ala carboxypeptidase activity	-	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15,SH3_3,SH3_4,VanY
CMS2_k127_5276270_8	401526.TcarDRAFT_1288	5.471e-19	102.0	28S81@1|root,2ZEJD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5276270_13	1254432.SCE1572_08085	2.024e-07	64.0	COG3250@1|root,COG3509@1|root,COG3250@2|Bacteria,COG3509@2|Bacteria,1R16M@1224|Proteobacteria	1224|Proteobacteria	Q	Ricin-type beta-trefoil	-	-	-	-	-	-	-	-	-	-	-	-	RicinB_lectin_2
CMS2_k127_5276270_12	345341.KUTG_08562	1.708e-08	69.0	COG5434@1|root,COG5434@2|Bacteria,2GKCR@201174|Actinobacteria,4E9Y2@85010|Pseudonocardiales	201174|Actinobacteria	M	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,NosD,Pectate_lyase_3
CMS2_k127_5276270_16	913865.DOT_3747	1.26e-05	59.0	COG3386@1|root,COG3386@2|Bacteria,1VQ21@1239|Firmicutes,24V9N@186801|Clostridia	186801|Clostridia	G	Pectate lyase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectate_lyase_3
CMS2_k127_5276270_10	316274.Haur_1031	9.135e-18	98.0	COG4627@1|root,COG4627@2|Bacteria	2|Bacteria	-	-	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	Glycos_transf_2,Methyltransf_11,Methyltransf_23
CMS2_k127_5276270_2	795359.TOPB45_0300	5.385e-42	166.0	COG0388@1|root,COG0615@1|root,COG0388@2|Bacteria,COG0615@2|Bacteria,2GHDJ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	IM	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase,CTP_transf_like
CMS2_k127_5276270_17	1122139.KB907863_gene1779	0.0005545	53.0	28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5276270_7	521097.Coch_0896	1.54e-21	109.0	2DBFR@1|root,2Z8ZR@2|Bacteria,4NG43@976|Bacteroidetes,1HZHP@117743|Flavobacteriia	976|Bacteroidetes	S	Terminase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_3,Terminase_6
CMS2_k127_5276270_5	536233.CLO_0530	1.387e-24	111.0	COG3728@1|root,COG3728@2|Bacteria,1VAD9@1239|Firmicutes,24JSU@186801|Clostridia,36X1Z@31979|Clostridiaceae	186801|Clostridia	L	Terminase small subunit	-	-	-	ko:K07474	-	-	-	-	ko00000	-	-	-	Terminase_2
CMS2_k127_5276270_9	760568.Desku_3205	1.527e-18	90.0	COG1743@1|root,COG1743@2|Bacteria,1TRIT@1239|Firmicutes,24AVX@186801|Clostridia,262DB@186807|Peptococcaceae	186801|Clostridia	L	DNA methylase	-	-	-	ko:K07445	-	-	-	-	ko00000	-	-	-	DUF1156
CMS2_k127_5276270_1	927677.ALVU02000002_gene214	1.131e-43	165.0	COG1310@1|root,COG1310@2|Bacteria	2|Bacteria	S	proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
CMS2_k127_5276270_14	1469607.KK073768_gene1027	1.902e-06	60.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	plyA1	-	-	ko:K12547	-	-	-	-	ko00000	-	-	-	Beta_helix,F5_F8_type_C,FIVAR,fn3
CMS2_k127_5276270_0	1408418.JNJH01000043_gene3127	2.205e-51	193.0	2FITE@1|root,34AIX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5294998_8	670487.Ocepr_0065	5.552e-29	127.0	COG4122@1|root,COG4122@2|Bacteria,1WKHV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
CMS2_k127_5294998_0	1403819.BATR01000092_gene2658	1.946e-196	624.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_5294998_2	1167006.UWK_02172	5.059e-165	530.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42ZBZ@68525|delta/epsilon subdivisions,2X5D0@28221|Deltaproteobacteria,2MMNI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	MacB_PCD
CMS2_k127_5294998_1	1167006.UWK_02172	7.206e-167	534.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42ZBZ@68525|delta/epsilon subdivisions,2X5D0@28221|Deltaproteobacteria,2MMNI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	MacB_PCD
CMS2_k127_5294998_5	1232437.KL662020_gene701	8.169e-94	313.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42NBA@68525|delta/epsilon subdivisions,2X5CP@28221|Deltaproteobacteria,2MJJB@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_5294998_3	1232437.KL662020_gene700	7.475e-157	517.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42PAC@68525|delta/epsilon subdivisions,2WKAD@28221|Deltaproteobacteria,2MMGU@213118|Desulfobacterales	28221|Deltaproteobacteria	M	HlyD membrane-fusion protein of T1SS	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS2_k127_5294998_4	1232437.KL662020_gene699	2.011e-145	484.0	COG1538@1|root,COG1538@2|Bacteria,1NQXF@1224|Proteobacteria,42ZDW@68525|delta/epsilon subdivisions,2WTVP@28221|Deltaproteobacteria,2MMSE@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_5294998_6	349741.Amuc_0502	1.664e-84	296.0	COG4299@1|root,COG4299@2|Bacteria,46S60@74201|Verrucomicrobia,2IUUP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5294998_9	1205680.CAKO01000040_gene590	1.441e-17	94.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
CMS2_k127_5294998_7	583355.Caka_1736	1.296e-81	297.0	COG2312@1|root,COG2312@2|Bacteria,46TMX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH,LTD
CMS2_k127_5294998_10	1122176.KB903531_gene3073	4.896e-13	83.0	COG2312@1|root,COG2312@2|Bacteria,4PP0J@976|Bacteroidetes	976|Bacteroidetes	E	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,LTD
CMS2_k127_5304131_0	1306990.BARG01000052_gene6152	1.605e-32	141.0	COG2730@1|root,COG2730@2|Bacteria,2IDXH@201174|Actinobacteria	201174|Actinobacteria	G	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
CMS2_k127_5304131_3	383372.Rcas_3962	2.009e-06	62.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Laminin_G_3,Pkinase
CMS2_k127_5304131_1	1242864.D187_001253	2.815e-12	81.0	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,438BA@68525|delta/epsilon subdivisions,2X3KK@28221|Deltaproteobacteria,2YWFN@29|Myxococcales	28221|Deltaproteobacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS2_k127_5304131_5	1270196.JCKI01000005_gene2800	0.0008996	43.0	COG2730@1|root,COG2730@2|Bacteria,4NF3J@976|Bacteroidetes,1IRPS@117747|Sphingobacteriia	976|Bacteroidetes	G	Putative collagen-binding domain of a collagenase	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038
CMS2_k127_5304131_4	886293.Sinac_2126	9.475e-06	49.0	COG3464@1|root,COG3464@2|Bacteria,2J105@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
CMS2_k127_5304131_2	234267.Acid_1992	1.631e-10	65.0	COG1680@1|root,COG1680@2|Bacteria,3Y8A8@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_5306637_2	484018.BACPLE_01371	8.162e-253	806.0	COG1554@1|root,COG1554@2|Bacteria,4NEWW@976|Bacteroidetes,2FMF9@200643|Bacteroidia,4AMRU@815|Bacteroidaceae	976|Bacteroidetes	G	COG NOG04001 non supervised orthologous group	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	Glyco_hyd_65N_2
CMS2_k127_5306637_0	1396141.BATP01000034_gene4198	2.402e-307	1023.0	COG1409@1|root,COG2273@1|root,COG5337@1|root,COG1409@2|Bacteria,COG2273@2|Bacteria,COG5337@2|Bacteria	2|Bacteria	M	Spore coat protein CotH	-	-	3.2.1.73	ko:K01216,ko:K07004	-	-	-	-	ko00000,ko01000	-	-	-	Big_4,CotH,DUF4971,F5_F8_type_C,Glyco_hydro_16,Glyco_hydro_43,HemolysinCabind,LTD,Laminin_G_3,Metallophos
CMS2_k127_5306637_3	880073.Calab_1872	5.095e-32	148.0	COG3630@1|root,COG5337@1|root,COG3630@2|Bacteria,COG5337@2|Bacteria	2|Bacteria	M	Spore coat protein CotH	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Fn3_assoc,LTD,OAD_gamma
CMS2_k127_5306637_4	1123070.KB899247_gene1611	1.694e-18	101.0	COG4675@1|root,COG4675@2|Bacteria	2|Bacteria	M	tail collar domain protein	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Collar,Laminin_G_3,Phage_fiber_2
CMS2_k127_5306637_1	1499967.BAYZ01000177_gene5733	6.179e-301	928.0	COG0677@1|root,COG0677@2|Bacteria,2NNV9@2323|unclassified Bacteria	2|Bacteria	M	UDP binding domain	-	-	1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520	-	R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS2_k127_5306637_5	1121920.AUAU01000011_gene191	1.435e-06	54.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,SBBP,Sortilin-Vps10
CMS2_k127_5354057_7	1121904.ARBP01000003_gene6344	6.131e-17	96.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5354057_0	1121904.ARBP01000008_gene3234	1.033e-130	445.0	COG5492@1|root,COG5492@2|Bacteria,4NEAB@976|Bacteroidetes,47TBW@768503|Cytophagia	976|Bacteroidetes	N	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060
CMS2_k127_5354057_6	1123242.JH636436_gene287	4.343e-28	119.0	COG0724@1|root,COG0724@2|Bacteria,2J0SR@203682|Planctomycetes	203682|Planctomycetes	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS2_k127_5354057_4	161156.JQKW01000008_gene504	2.256e-38	162.0	COG1032@1|root,COG1032@2|Bacteria,2GI0E@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_5354057_1	640511.BC1002_6699	8.838e-117	392.0	COG1032@1|root,COG1032@2|Bacteria,1R92G@1224|Proteobacteria,2WB71@28216|Betaproteobacteria,1K09Q@119060|Burkholderiaceae	28216|Betaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS2_k127_5354057_10	1396141.BATP01000033_gene4242	1.25e-07	64.0	COG3533@1|root,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Laminin_G_3
CMS2_k127_5354057_2	935948.KE386495_gene1170	3.226e-44	181.0	COG3055@1|root,COG3055@2|Bacteria,1V8SQ@1239|Firmicutes,25BH8@186801|Clostridia	186801|Clostridia	E	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1
CMS2_k127_5354057_9	1121878.AUGL01000024_gene3725	1.235e-10	76.0	COG0824@1|root,COG1520@1|root,COG2133@1|root,COG2273@1|root,COG3291@1|root,COG3507@1|root,COG3866@1|root,COG4733@1|root,COG0824@2|Bacteria,COG1520@2|Bacteria,COG2133@2|Bacteria,COG2273@2|Bacteria,COG3291@2|Bacteria,COG3507@2|Bacteria,COG3866@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.31,3.2.1.45	ko:K01195,ko:K01201,ko:K07107,ko:K20276	ko00040,ko00511,ko00531,ko00600,ko00860,ko00944,ko00983,ko01100,ko01110,ko02024,ko04142,map00040,map00511,map00531,map00600,map00860,map00944,map00983,map01100,map01110,map02024,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R01498,R04979,R07818,R08127,R08260,R10830	RC00055,RC00059,RC00171,RC00451,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	GH30	-	CBM_6,DUF1349,GSDH,PKD,RicinB_lectin_2,ThuA
CMS2_k127_5354057_5	84531.JMTZ01000001_gene2271	1.734e-33	151.0	COG3291@1|root,COG3420@1|root,COG4935@1|root,COG3291@2|Bacteria,COG3420@2|Bacteria,COG4935@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	3.4.11.10,3.4.21.50,3.4.24.25,3.4.24.3	ko:K01337,ko:K01387,ko:K05994,ko:K08604,ko:K14645,ko:K20276	ko02024,ko05110,ko05111,map02024,map05110,map05111	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02042,ko03110	-	-	-	Inhibitor_I9,LVIVD,PKD,P_proprotein,Peptidase_M14,Peptidase_S8
CMS2_k127_5354057_3	794903.OPIT5_13605	1.07e-42	172.0	COG3210@1|root,COG3420@1|root,COG3210@2|Bacteria,COG3420@2|Bacteria,46UU9@74201|Verrucomicrobia,3K9Q3@414999|Opitutae	414999|Opitutae	U	haemagglutination activity domain	-	-	-	-	-	-	-	-	-	-	-	-	Haemagg_act
CMS2_k127_5386155_6	497964.CfE428DRAFT_4230	3.092e-89	306.0	COG3356@1|root,COG3356@2|Bacteria,46UC2@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
CMS2_k127_5386155_2	344747.PM8797T_14434	3.336e-159	553.0	COG1506@1|root,COG1506@2|Bacteria,2IYE5@203682|Planctomycetes	203682|Planctomycetes	E	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
CMS2_k127_5386155_0	595460.RRSWK_06162	1.434e-219	696.0	COG5492@1|root,COG5492@2|Bacteria,2IYV9@203682|Planctomycetes	203682|Planctomycetes	N	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060
CMS2_k127_5386155_1	661478.OP10G_1321	6.014e-167	541.0	COG3525@1|root,COG3525@2|Bacteria	2|Bacteria	G	beta-N-acetylhexosaminidase activity	nahA	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	CHB_HEX_C_1,Glyco_hydro_20,Glyco_hydro_20b
CMS2_k127_5386155_5	1168034.FH5T_21900	1.379e-98	330.0	COG1208@1|root,COG1208@2|Bacteria,4PKJR@976|Bacteroidetes,2G07F@200643|Bacteroidia	976|Bacteroidetes	JM	COG NOG09722 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
CMS2_k127_5386155_4	1267534.KB906755_gene4819	3.727e-117	387.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	mdsC	-	2.7.1.162,2.7.1.39	ko:K02204,ko:K13059	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771,R08962	RC00002,RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
CMS2_k127_5386155_3	639030.JHVA01000001_gene3516	4.497e-126	420.0	COG3345@1|root,COG3345@2|Bacteria,3Y44J@57723|Acidobacteria,2JIVW@204432|Acidobacteriia	204432|Acidobacteriia	G	alpha-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5387054_0	7668.SPU_002506-tr	5.058e-11	77.0	COG5368@1|root,2S0SI@2759|Eukaryota,3A2ZU@33154|Opisthokonta,3BQVS@33208|Metazoa,3D7JZ@33213|Bilateria	33208|Metazoa	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS2_k127_5387054_1	376686.Fjoh_2456	5.499e-09	70.0	COG3866@1|root,COG3866@2|Bacteria,4NJUK@976|Bacteroidetes,1IIIB@117743|Flavobacteriia,2NUS2@237|Flavobacterium	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5412545_1	186497.PF1397	4.882e-106	353.0	COG1180@1|root,arCOG00946@2157|Archaea,2XUB7@28890|Euryarchaeota,242R9@183968|Thermococci	183968|Thermococci	O	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS2_k127_5412545_0	648996.Theam_1063	7.917e-164	538.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2G3K2@200783|Aquificae	200783|Aquificae	L	DNA polymerase	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
CMS2_k127_5412545_2	1142394.PSMK_27400	1.029e-52	192.0	COG0745@1|root,COG0745@2|Bacteria,2IY82@203682|Planctomycetes	203682|Planctomycetes	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Response_reg
CMS2_k127_5422188_4	1396141.BATP01000027_gene1160	5.041e-19	103.0	COG2273@1|root,COG2755@1|root,COG3064@1|root,COG3291@1|root,COG5306@1|root,COG2273@2|Bacteria,COG2755@2|Bacteria,COG3064@2|Bacteria,COG3291@2|Bacteria,COG5306@2|Bacteria,46X9M@74201|Verrucomicrobia,2IV4C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EGM	Peptidase M60-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,M60-like_N,PA14,Peptidase_M60
CMS2_k127_5422188_0	926554.KI912660_gene2390	1.046e-29	138.0	COG2133@1|root,COG3858@1|root,COG2133@2|Bacteria,COG3858@2|Bacteria	2|Bacteria	S	chitin binding	ydhD1	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	Cu_amine_oxidN1,Glyco_hydro_18
CMS2_k127_5422188_1	382464.ABSI01000006_gene874	8.909e-29	126.0	COG1595@1|root,COG1595@2|Bacteria,46XM2@74201|Verrucomicrobia,2IW65@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_5422188_2	1128421.JAGA01000001_gene2407	7.16e-23	112.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
CMS2_k127_5430889_3	880073.Calab_3333	3.397e-30	130.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5430889_1	1120968.AUBX01000001_gene2225	1.827e-154	505.0	COG3119@1|root,COG3119@2|Bacteria,4NEPB@976|Bacteroidetes,47U3H@768503|Cytophagia	976|Bacteroidetes	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_5430889_0	452637.Oter_2229	1.966e-246	796.0	COG2273@1|root,COG2273@2|Bacteria	2|Bacteria	G	xyloglucan:xyloglucosyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Glyco_hydro_16,Glyco_transf_25,Malectin,Ricin_B_lectin,Trans_reg_C,Trypsin,VCBS
CMS2_k127_5430889_2	186497.PF0041	3.306e-120	402.0	COG1031@1|root,arCOG01359@2157|Archaea,2XSVQ@28890|Euryarchaeota,242MX@183968|Thermococci	183968|Thermococci	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Radical_SAM
CMS2_k127_5481978_1	452637.Oter_4175	1.048e-113	376.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,46VB0@74201|Verrucomicrobia,3K8AK@414999|Opitutae	414999|Opitutae	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_5481978_2	344747.PM8797T_27367	4.129e-59	211.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_5481978_0	509191.AEDB02000002_gene1137	5.052e-132	452.0	COG0823@1|root,COG0823@2|Bacteria,1VP24@1239|Firmicutes,24WTQ@186801|Clostridia,3WN5Z@541000|Ruminococcaceae	186801|Clostridia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
CMS2_k127_5481978_3	344747.PM8797T_14549	5.727e-19	94.0	COG3356@1|root,COG3356@2|Bacteria,2IX5S@203682|Planctomycetes	2|Bacteria	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
CMS2_k127_5494819_5	59374.Fisuc_2002	3.012e-07	62.0	COG3866@1|root,COG4733@1|root,COG3866@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Laminin_G_3,fn3
CMS2_k127_5494819_3	1116232.AHBF01000079_gene8431	1.861e-44	176.0	COG3533@1|root,COG3533@2|Bacteria,2GM60@201174|Actinobacteria	201174|Actinobacteria	G	protein conserved in bacteria	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	CBM_6,Glyco_hydro_127,Laminin_G_3
CMS2_k127_5494819_4	1303518.CCALI_01797	1.269e-14	85.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456,ko:K02650	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	N_methyl,SBP_bac_10,T2SSG
CMS2_k127_5494819_0	1191523.MROS_0031	1.28e-285	887.0	COG4146@1|root,COG4146@2|Bacteria	2|Bacteria	S	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_5494819_1	518766.Rmar_0469	6.534e-235	738.0	COG1069@1|root,COG1069@2|Bacteria,4NEFQ@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the ribulokinase family	araB	-	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
CMS2_k127_5494819_2	1336241.JAEB01000002_gene298	2.16e-63	227.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia,25UZF@186806|Eubacteriaceae	186801|Clostridia	G	Class II Aldolase and Adducin N-terminal domain	ulaF	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
CMS2_k127_5510009_3	335543.Sfum_0987	3.584e-22	100.0	COG0640@1|root,COG0640@2|Bacteria,1RGYC@1224|Proteobacteria,42X86@68525|delta/epsilon subdivisions,2WSJA@28221|Deltaproteobacteria,2MSBA@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
CMS2_k127_5510009_0	1121396.KB893068_gene1423	8.782e-298	940.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MMR2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Sterol-sensing domain of SREBP cleavage-activation	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	GGDEF,LolA_like,MMPL,cNMP_binding
CMS2_k127_5510009_2	1232410.KI421422_gene2100	2.154e-22	98.0	COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,42VWR@68525|delta/epsilon subdivisions,2WS4U@28221|Deltaproteobacteria,43VU0@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
CMS2_k127_5510009_1	1125863.JAFN01000001_gene70	1.866e-91	311.0	COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,42MX6@68525|delta/epsilon subdivisions,2WMMJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS2_k127_5510009_4	526222.Desal_0455	1.578e-14	83.0	COG4773@1|root,COG4773@2|Bacteria,1QCTH@1224|Proteobacteria,42PPC@68525|delta/epsilon subdivisions,2WIS8@28221|Deltaproteobacteria,2MAAG@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5512674_2	877424.ATWC01000022_gene2515	5.241e-13	78.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,248RH@186801|Clostridia,27JNU@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
CMS2_k127_5512674_1	926569.ANT_03810	1.479e-53	204.0	COG3583@1|root,COG3584@1|root,COG3583@2|Bacteria,COG3584@2|Bacteria,2G8CU@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF348)	-	-	-	-	-	-	-	-	-	-	-	-	DUF348,G5
CMS2_k127_5512674_0	497965.Cyan7822_4974	3.485e-112	374.0	COG0075@1|root,COG0075@2|Bacteria,1G2P6@1117|Cyanobacteria,3KGD2@43988|Cyanothece	1117|Cyanobacteria	H	PFAM aminotransferase class V	spt	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
CMS2_k127_5525832_4	1121346.KB899864_gene304	3.994e-21	100.0	COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,4H9WD@91061|Bacilli,26R0X@186822|Paenibacillaceae	91061|Bacilli	I	to YegS from E. coli	dagK	GO:0003674,GO:0003824,GO:0004143,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
CMS2_k127_5525832_3	1125701.HMPREF1221_01616	1.166e-38	162.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5525832_2	211165.AJLN01000094_gene1166	6.015e-74	263.0	2ABPF@1|root,3115E@2|Bacteria,1GC9B@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5525832_5	1395571.TMS3_0107060	1.28e-16	94.0	COG4885@1|root,COG4885@2|Bacteria,1R65B@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_CBB3
CMS2_k127_5525832_1	926550.CLDAP_07830	2.588e-84	312.0	COG4447@1|root,COG4447@2|Bacteria,2G66V@200795|Chloroflexi	200795|Chloroflexi	G	glycosyl hydrolase, BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
CMS2_k127_5525832_0	485917.Phep_0352	5.771e-187	594.0	COG0399@1|root,COG0399@2|Bacteria,4NJKH@976|Bacteroidetes,1IURF@117747|Sphingobacteriia	976|Bacteroidetes	M	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_5529163_4	1195236.CTER_4883	3.713e-112	393.0	COG2006@1|root,COG2006@2|Bacteria,1VRZ8@1239|Firmicutes,24Z9V@186801|Clostridia,3WN5G@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Dockerin_1
CMS2_k127_5529163_3	1158294.JOMI01000004_gene3543	4.591e-125	431.0	COG3386@1|root,COG3386@2|Bacteria,4NF4A@976|Bacteroidetes,2FSDK@200643|Bacteroidia	976|Bacteroidetes	G	SMP-30 Gluconolaconase LRE-like	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pectate_lyase_3,SGL
CMS2_k127_5529163_1	1379698.RBG1_1C00001G0607	1.629e-173	572.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
CMS2_k127_5529163_6	344747.PM8797T_17202	8.947e-88	301.0	COG1621@1|root,COG1621@2|Bacteria,2IZ2Q@203682|Planctomycetes	203682|Planctomycetes	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5529163_7	1158602.I590_01526	6.446e-05	47.0	2E3YR@1|root,32YVP@2|Bacteria,1TZJC@1239|Firmicutes,4I8U6@91061|Bacilli,4B388@81852|Enterococcaceae	91061|Bacilli	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
CMS2_k127_5529163_5	497964.CfE428DRAFT_0641	1.359e-98	335.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
CMS2_k127_5529163_2	497964.CfE428DRAFT_0642	3.806e-126	441.0	COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
CMS2_k127_5529163_0	926550.CLDAP_17510	5.31e-201	655.0	COG5337@1|root,COG5337@2|Bacteria	2|Bacteria	M	Spore coat protein CotH	-	-	-	-	-	-	-	-	-	-	-	-	CotH,LTD
CMS2_k127_5541383_0	237368.SCABRO_02564	5.571e-90	316.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,2IZEZ@203682|Planctomycetes	203682|Planctomycetes	S	Memo-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1,Memo
CMS2_k127_5541383_4	713587.THITH_12510	1.446e-42	181.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria	1224|Proteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
CMS2_k127_5541383_7	311424.DhcVS_1480	6.957e-24	120.0	COG0348@1|root,COG4659@1|root,COG0348@2|Bacteria,COG4659@2|Bacteria,2GANM@200795|Chloroflexi,34CW0@301297|Dehalococcoidia	301297|Dehalococcoidia	C	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind,Fer4_5
CMS2_k127_5541383_10	266779.Meso_3504	2.022e-13	72.0	COG3071@1|root,COG3071@2|Bacteria,1N6Y8@1224|Proteobacteria,2UFTD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
CMS2_k127_5541383_1	13689.BV96_03120	5.535e-83	282.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,2TT1D@28211|Alphaproteobacteria,2K8RV@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
CMS2_k127_5541383_9	1122216.AUHW01000035_gene1205	2.693e-15	88.0	COG0477@1|root,COG2814@2|Bacteria,1UJ0G@1239|Firmicutes,4H2N5@909932|Negativicutes	909932|Negativicutes	EGP	Transporter major facilitator family protein	fsr	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS2_k127_5541383_3	1128421.JAGA01000003_gene3155	3.406e-46	177.0	COG0130@1|root,COG0130@2|Bacteria,2NP9J@2323|unclassified Bacteria	2|Bacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C,TruB_C_2,TruB_N
CMS2_k127_5541383_5	335541.Swol_1076	2.427e-40	166.0	COG5492@1|root,COG5492@2|Bacteria,1V7TS@1239|Firmicutes,25F4B@186801|Clostridia,42KX4@68298|Syntrophomonadaceae	2|Bacteria	N	Surface proteins containing Ig-like domains-like	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CBM_X2,CHB_HEX_C_1,Flg_new,Glug,SLH
CMS2_k127_5541383_2	1499967.BAYZ01000145_gene6207	3.692e-72	251.0	COG1028@1|root,COG1028@2|Bacteria,2NQVU@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
CMS2_k127_5541383_6	156889.Mmc1_0329	9.566e-36	139.0	COG1539@1|root,COG1539@2|Bacteria	2|Bacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008719,GO:0009987,GO:0016853,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0071704,GO:1901360,GO:1901564	1.13.11.81,4.1.2.25,5.1.99.7,5.1.99.8	ko:K01633,ko:K07589	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073,R11082	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
CMS2_k127_5541383_8	192952.MM_1144	1.414e-15	90.0	COG5563@1|root,arCOG03499@1|root,arCOG03499@2157|Archaea,arCOG03501@2157|Archaea	2157|Archaea	S	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Disaggr_assoc,Disaggr_repeat,PKD
CMS2_k127_5555408_3	1177594.MIC448_830010	9.853e-33	132.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CarboxypepD_reg,HemolysinCabind
CMS2_k127_5555408_0	1168034.FH5T_20035	8.22e-135	438.0	COG2502@1|root,COG2502@2|Bacteria,4NFZA@976|Bacteroidetes,2FMP0@200643|Bacteroidia	976|Bacteroidetes	E	aspartate--ammonia ligase	asnA	-	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	-	R00483	RC00010	ko00000,ko00001,ko01000	-	-	-	AsnA
CMS2_k127_5555408_2	1192034.CAP_8404	9.366e-80	283.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	4.2.2.3	ko:K01729	ko00051,map00051	-	R03706	-	ko00000,ko00001,ko01000	-	-	-	Beta_helix,Chondroitinas_B
CMS2_k127_5555408_1	861299.J421_1078	2.833e-125	408.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	ramA	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
CMS2_k127_5555408_4	1128421.JAGA01000001_gene2407	5.265e-22	106.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
CMS2_k127_5564660_8	1142394.PSMK_03050	4.208e-40	158.0	COG5012@1|root,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_fact
CMS2_k127_5564660_1	344747.PM8797T_01654	5.198e-196	625.0	COG0119@1|root,COG0119@2|Bacteria,2IXBC@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
CMS2_k127_5564660_9	1142394.PSMK_13590	8.752e-39	151.0	COG1762@1|root,COG1762@2|Bacteria,2IZ73@203682|Planctomycetes	203682|Planctomycetes	G	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	-	-	2.7.1.202	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
CMS2_k127_5564660_0	1125863.JAFN01000001_gene3117	8.781e-303	951.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM glycosyl transferase, family 35	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
CMS2_k127_5564660_3	237368.SCABRO_03203	5.743e-146	486.0	COG0072@1|root,COG0072@2|Bacteria,2IX0Q@203682|Planctomycetes	203682|Planctomycetes	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
CMS2_k127_5564660_2	1380391.JIAS01000012_gene4526	1.99e-146	475.0	COG4948@1|root,COG4948@2|Bacteria,1R63G@1224|Proteobacteria,2TT3A@28211|Alphaproteobacteria,2JW8D@204441|Rhodospirillales	204441|Rhodospirillales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
CMS2_k127_5564660_10	344747.PM8797T_12478	2.315e-36	144.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
CMS2_k127_5564660_4	344747.PM8797T_21358	2.687e-129	429.0	COG0464@1|root,COG0464@2|Bacteria	2|Bacteria	O	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS2_k127_5564660_16	886293.Sinac_4935	7.822e-21	96.0	2DVHI@1|root,32UZG@2|Bacteria,2J0QY@203682|Planctomycetes	203682|Planctomycetes	S	PFAM PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
CMS2_k127_5564660_5	880073.Calab_2000	3.719e-111	367.0	COG0451@1|root,COG0451@2|Bacteria,2NNNX@2323|unclassified Bacteria	2|Bacteria	GM	NAD(P)H-binding	wbpP	-	5.1.3.2,5.1.3.7	ko:K01784,ko:K02473	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R00418,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS2_k127_5564660_7	1121456.ATVA01000012_gene2942	8.733e-45	186.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,42NB4@68525|delta/epsilon subdivisions,2WK9E@28221|Deltaproteobacteria,2M8NV@213115|Desulfovibrionales	28221|Deltaproteobacteria	DM	PFAM lipopolysaccharide biosynthesis protein	wzc2	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
CMS2_k127_5564660_17	1279019.ARQK01000059_gene905	9.063e-18	100.0	COG0457@1|root,COG3118@1|root,COG5010@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,COG5010@2|Bacteria,1MXMD@1224|Proteobacteria,1RSI5@1236|Gammaproteobacteria,1WX1E@135613|Chromatiales	135613|Chromatiales	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_4,TPR_6,TPR_8
CMS2_k127_5564660_18	1142394.PSMK_22340	2.09e-07	61.0	COG1269@1|root,COG1269@2|Bacteria,2IZU8@203682|Planctomycetes	203682|Planctomycetes	C	PFAM Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
CMS2_k127_5564660_11	886293.Sinac_5880	1.602e-34	147.0	COG1269@1|root,COG1269@2|Bacteria,2IZU8@203682|Planctomycetes	203682|Planctomycetes	C	PFAM Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
CMS2_k127_5564660_6	1142394.PSMK_22330	8e-47	191.0	COG1596@1|root,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
CMS2_k127_5564660_15	714943.Mucpa_4406	5.746e-25	110.0	COG1848@1|root,COG1848@2|Bacteria,4PC3N@976|Bacteroidetes,1IYZV@117747|Sphingobacteriia	976|Bacteroidetes	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5564660_12	29875.EHK23726	3.656e-31	136.0	COG0666@1|root,KOG0504@2759|Eukaryota,39YNX@33154|Opisthokonta,3PHTC@4751|Fungi,3R54F@4890|Ascomycota,21R6B@147550|Sordariomycetes,3TUVS@5125|Hypocreales,3U4UP@5129|Hypocreaceae	4751|Fungi	S	Phosphorylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5,NACHT,PNP_UDP_1
CMS2_k127_5564660_13	247490.KSU1_C0558	1.437e-28	117.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
CMS2_k127_5564660_14	211165.AJLN01000051_gene4966	4.335e-28	114.0	COG1598@1|root,COG1598@2|Bacteria,1G998@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5580496_2	1396141.BATP01000027_gene1160	6.572e-12	77.0	COG2273@1|root,COG2755@1|root,COG3064@1|root,COG3291@1|root,COG5306@1|root,COG2273@2|Bacteria,COG2755@2|Bacteria,COG3064@2|Bacteria,COG3291@2|Bacteria,COG5306@2|Bacteria,46X9M@74201|Verrucomicrobia,2IV4C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EGM	Peptidase M60-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,M60-like_N,PA14,Peptidase_M60
CMS2_k127_5580496_0	1396141.BATP01000027_gene1160	3.931e-51	209.0	COG2273@1|root,COG2755@1|root,COG3064@1|root,COG3291@1|root,COG5306@1|root,COG2273@2|Bacteria,COG2755@2|Bacteria,COG3064@2|Bacteria,COG3291@2|Bacteria,COG5306@2|Bacteria,46X9M@74201|Verrucomicrobia,2IV4C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EGM	Peptidase M60-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,M60-like_N,PA14,Peptidase_M60
CMS2_k127_5580496_3	1396141.BATP01000032_gene4352	1.558e-09	72.0	COG0741@1|root,COG0741@2|Bacteria	2|Bacteria	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	LysM,PG_binding_1,SLT
CMS2_k127_5580496_1	1353528.DT23_18460	7.9e-49	191.0	COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2TTVB@28211|Alphaproteobacteria,2XP2F@285107|Thioclava	28211|Alphaproteobacteria	U	haemagglutination activity domain	-	-	-	-	-	-	-	-	-	-	-	-	ESPR,FG-GAP_2,Glug,Haemagg_act
CMS2_k127_5597307_2	107636.JQNK01000010_gene650	1.846e-19	91.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,36XY4@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
CMS2_k127_5597307_3	344747.PM8797T_03234	6.541e-09	62.0	COG2230@1|root,COG2230@2|Bacteria,2J0X9@203682|Planctomycetes	203682|Planctomycetes	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.103	ko:K05929	ko00564,map00564	-	R02037,R06868,R06869	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko01000	-	-	-	-
CMS2_k127_5597307_6	443143.GM18_4455	0.0001727	55.0	COG1413@1|root,COG1413@2|Bacteria,1P4H5@1224|Proteobacteria,42WD8@68525|delta/epsilon subdivisions,2WRJT@28221|Deltaproteobacteria,43UWV@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
CMS2_k127_5597307_1	234267.Acid_0845	1.014e-30	140.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	cpeZ	-	-	ko:K05384,ko:K05386	ko00196,ko01100,map00196,map01100	-	-	-	ko00000,ko00001,ko00194	-	-	-	HEAT_2
CMS2_k127_5597307_0	344747.PM8797T_11556	5.451e-112	376.0	COG0673@1|root,COG0673@2|Bacteria,2IXA3@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5597307_4	161156.JQKW01000008_gene429	1.175e-08	55.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
CMS2_k127_5602780_3	1211813.CAPH01000017_gene773	5.324e-31	124.0	COG3408@1|root,COG3408@2|Bacteria,4P4HZ@976|Bacteroidetes	976|Bacteroidetes	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5602780_0	497964.CfE428DRAFT_5737	3.058e-189	598.0	COG0673@1|root,COG0673@2|Bacteria,46UQI@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5602780_5	234267.Acid_6615	8.083e-09	66.0	28KX8@1|root,2ZAD8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5602780_1	1121012.AUKX01000016_gene3001	1.167e-157	515.0	COG0673@1|root,COG0673@2|Bacteria,4NGTW@976|Bacteroidetes,1I164@117743|Flavobacteriia,23IAD@178469|Arenibacter	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5602780_2	573413.Spirs_1747	3.195e-63	230.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
CMS2_k127_5602780_4	742738.HMPREF9460_00523	7.831e-10	61.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,24NIH@186801|Clostridia,269X0@186813|unclassified Clostridiales	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5603133_6	1122603.ATVI01000006_gene75	5.273e-36	143.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1X4Q2@135614|Xanthomonadales	135614|Xanthomonadales	S	transporter	oliA	-	-	-	-	-	-	-	-	-	-	-	OPT
CMS2_k127_5603133_1	886293.Sinac_3283	2.39e-137	450.0	COG0624@1|root,COG0624@2|Bacteria,2IXPJ@203682|Planctomycetes	203682|Planctomycetes	E	ArgE DapE Acy1 family protein	-	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
CMS2_k127_5603133_2	1382306.JNIM01000001_gene398	1.053e-93	314.0	COG0313@1|root,COG0313@2|Bacteria,2G5VQ@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
CMS2_k127_5603133_4	357808.RoseRS_3038	1.213e-50	188.0	COG1385@1|root,COG1385@2|Bacteria,2G70G@200795|Chloroflexi,3779B@32061|Chloroflexia	32061|Chloroflexia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
CMS2_k127_5603133_3	518766.Rmar_0069	4.726e-62	224.0	COG0564@1|root,COG0564@2|Bacteria,4NHKH@976|Bacteroidetes	976|Bacteroidetes	J	Pseudouridine synthase	-	-	5.4.99.23,5.4.99.24	ko:K06179,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
CMS2_k127_5603133_7	443143.GM18_1629	4.869e-35	144.0	2EMTG@1|root,33FFU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
CMS2_k127_5603133_5	886293.Sinac_6200	6.669e-48	177.0	COG0231@1|root,COG0231@2|Bacteria,2IZ4X@203682|Planctomycetes	203682|Planctomycetes	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
CMS2_k127_5603133_0	697282.Mettu_0616	1.737e-177	563.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,1XEW5@135618|Methylococcales	135618|Methylococcales	C	Apoptosis-inducing factor, mitochondrion-associated, C-term	-	-	-	-	-	-	-	-	-	-	-	-	AIF_C,Pyr_redox_2
CMS2_k127_5603133_8	1396141.BATP01000027_gene1160	3.797e-17	88.0	COG2273@1|root,COG2755@1|root,COG3064@1|root,COG3291@1|root,COG5306@1|root,COG2273@2|Bacteria,COG2755@2|Bacteria,COG3064@2|Bacteria,COG3291@2|Bacteria,COG5306@2|Bacteria,46X9M@74201|Verrucomicrobia,2IV4C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EGM	Peptidase M60-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,M60-like_N,PA14,Peptidase_M60
CMS2_k127_5626424_8	1123508.JH636439_gene506	1.446e-11	66.0	COG4968@1|root,COG4968@2|Bacteria,2J51Q@203682|Planctomycetes	203682|Planctomycetes	NU	Protein of unknown function (DUF1559)	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_5626424_1	649638.Trad_0907	4.511e-130	433.0	COG4284@1|root,COG4284@2|Bacteria	2|Bacteria	G	Utp--glucose-1-phosphate uridylyltransferase	CP_1013	-	2.7.7.23,2.7.7.83	ko:K00972,ko:K11442	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00361,M00362	R00416	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
CMS2_k127_5626424_15	1173028.ANKO01000227_gene1237	0.000885	46.0	2CCSR@1|root,32RWC@2|Bacteria,1GA04@1117|Cyanobacteria,1HDA0@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
CMS2_k127_5626424_2	1353531.AZNX01000005_gene3441	1.318e-127	417.0	COG2017@1|root,COG2017@2|Bacteria,1MVMN@1224|Proteobacteria,2TTJ7@28211|Alphaproteobacteria,4BC0Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Aldose 1-epimerase	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
CMS2_k127_5626424_10	59374.Fisuc_2002	1.46e-07	64.0	COG3866@1|root,COG4733@1|root,COG3866@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Laminin_G_3,fn3
CMS2_k127_5626424_4	1168034.FH5T_18580	8.877e-32	143.0	COG1572@1|root,COG3210@1|root,COG4625@1|root,COG4932@1|root,COG1572@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria,4PN5X@976|Bacteroidetes	976|Bacteroidetes	M	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_5626424_0	59374.Fisuc_3113	7.281e-155	510.0	COG0500@1|root,COG2021@1|root,COG2021@2|Bacteria,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,MetW
CMS2_k127_5626424_11	216594.MMAR_0026	8.146e-07	58.0	2ED9D@1|root,3375U@2|Bacteria,2H989@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5626424_3	344747.PM8797T_17102	1.456e-111	374.0	COG0582@1|root,COG0582@2|Bacteria,2IZWA@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_5,Phage_integrase
CMS2_k127_5626424_13	1122239.AULS01000008_gene2431	4.835e-05	51.0	COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria	2|Bacteria	L	Transposase	tnp3514a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve
CMS2_k127_5626424_7	637389.Acaty_c1034	1.675e-12	79.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria,2NDI8@225057|Acidithiobacillales	225057|Acidithiobacillales	L	PFAM Integrase, catalytic core	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve
CMS2_k127_5626424_9	5127.CCT65277	7.311e-10	63.0	COG0666@1|root,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3P0CS@4751|Fungi,3QQN4@4890|Ascomycota,218IW@147550|Sordariomycetes,3TME0@5125|Hypocreales,1FVHZ@110618|Nectriaceae	4751|Fungi	M	Prion-inhibition and propagation	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,HeLo,NACHT
CMS2_k127_5626424_6	856793.MICA_1642	1.321e-12	81.0	COG1520@1|root,COG3534@1|root,COG1520@2|Bacteria,COG3534@2|Bacteria	2|Bacteria	G	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43,Laminin_G_3,PQQ_2
CMS2_k127_5626424_12	755732.Fluta_3108	1.363e-05	58.0	COG1729@1|root,COG2885@1|root,COG1729@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1HXNY@117743|Flavobacteriia,2PBBP@246874|Cryomorphaceae	976|Bacteroidetes	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,OmpA,PD40
CMS2_k127_5626424_5	1408813.AYMG01000034_gene4493	2.115e-20	106.0	COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1IPCG@117747|Sphingobacteriia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
CMS2_k127_5649745_5	794903.OPIT5_19160	7.11e-63	231.0	COG2911@1|root,COG3210@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	ko:K15125	ko05133,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	Beta_helix,CUB,Calx-beta,DUF3739,Haemagg_act,SdrD_B
CMS2_k127_5649745_11	1380387.JADM01000020_gene3708	2.362e-25	123.0	COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,1RYVX@1236|Gammaproteobacteria,1XKSD@135619|Oceanospirillales	135619|Oceanospirillales	U	Haemolysin secretion/activation protein ShlB/FhaC/HecB	-	-	-	-	-	-	-	-	-	-	-	-	POTRA_2,ShlB
CMS2_k127_5649745_2	595460.RRSWK_00701	1.485e-131	435.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF1566,FGE-sulfatase,Lactamase_B_2,PD40,Peptidase_S9
CMS2_k127_5649745_6	344747.PM8797T_27367	4.627e-59	217.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_5649745_1	1267533.KB906735_gene5020	7.545e-183	606.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,TPR_8
CMS2_k127_5649745_12	1280946.HY29_04050	1.281e-16	85.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,2UA4W@28211|Alphaproteobacteria,4405V@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	-	-	2.7.13.3	ko:K03407,ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	Hpt,Response_reg
CMS2_k127_5649745_9	1122609.AUGT01000023_gene472	5.409e-34	149.0	COG5002@1|root,COG5002@2|Bacteria,2I2TP@201174|Actinobacteria,4DU7T@85009|Propionibacteriales	201174|Actinobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
CMS2_k127_5649745_7	1379270.AUXF01000001_gene1941	1.409e-54	214.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZUHA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
CMS2_k127_5649745_14	1142394.PSMK_09260	1.579e-15	87.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_5649745_10	1122165.AUHS01000004_gene3173	1.38e-28	134.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	3.2.1.136	ko:K15924	-	-	-	-	ko00000,ko01000	-	GH5	-	CBM_3,Dockerin_1,Flg_new,Glyco_hydro_9
CMS2_k127_5649745_13	717774.Marme_2389	1.681e-16	83.0	2E8FY@1|root,332U8@2|Bacteria,1N8EY@1224|Proteobacteria,1SD25@1236|Gammaproteobacteria,1XQEV@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5649745_8	296591.Bpro_3359	6.082e-39	149.0	COG0527@1|root,COG0527@2|Bacteria,1REUY@1224|Proteobacteria,2VS69@28216|Betaproteobacteria	28216|Betaproteobacteria	E	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT,ACT_6
CMS2_k127_5649745_3	880073.Calab_0491	1.996e-67	235.0	COG1881@1|root,COG1881@2|Bacteria,2NPDK@2323|unclassified Bacteria	2|Bacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
CMS2_k127_5649745_4	344747.PM8797T_27367	8.633e-64	226.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_5649745_0	234267.Acid_5676	5.371e-207	683.0	COG0515@1|root,COG1262@1|root,COG1506@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	1.14.99.50,2.7.11.1	ko:K01990,ko:K08884,ko:K12132,ko:K18912	ko00340,map00340	M00254	R11013	RC03323,RC03324	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000	3.A.1	-	-	FGE-sulfatase,Peptidase_S15,Pkinase
CMS2_k127_5649745_15	1116375.VEJY3_08135	1.348e-09	65.0	COG3291@1|root,COG3291@2|Bacteria,1QXQ7@1224|Proteobacteria,1T3G4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_56498_9	679937.Bcop_1252	0.0008517	51.0	COG2407@1|root,COG2407@2|Bacteria,4P1BT@976|Bacteroidetes,2FMIE@200643|Bacteroidia,4AKFB@815|Bacteroidaceae	976|Bacteroidetes	G	COG2407 L-fucose isomerase and related	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_56498_6	1449063.JMLS01000018_gene5960	3.33e-41	169.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,4HATN@91061|Bacilli,26QJK@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
CMS2_k127_56498_5	1385935.N836_21710	2.455e-45	169.0	COG0454@1|root,COG0456@2|Bacteria,1G8NU@1117|Cyanobacteria	1117|Cyanobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS2_k127_56498_0	278957.ABEA03000041_gene2046	4.257e-190	615.0	COG3250@1|root,COG3250@2|Bacteria,46YAN@74201|Verrucomicrobia,3K989@414999|Opitutae	414999|Opitutae	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_56498_4	595460.RRSWK_03713	3.899e-47	193.0	COG1305@1|root,COG1305@2|Bacteria,2IZUN@203682|Planctomycetes	203682|Planctomycetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
CMS2_k127_56498_3	595460.RRSWK_03714	1.944e-59	223.0	COG1721@1|root,COG1721@2|Bacteria,2J13Q@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS2_k127_56498_1	344747.PM8797T_07674	1.839e-119	392.0	COG0714@1|root,COG0714@2|Bacteria,2IX1F@203682|Planctomycetes	203682|Planctomycetes	S	ATPase associated with	-	-	-	-	-	-	-	-	-	-	-	-	AAA_3
CMS2_k127_56498_8	1499967.BAYZ01000069_gene1916	1.106e-26	126.0	COG1262@1|root,COG1262@2|Bacteria,2NR8C@2323|unclassified Bacteria	2|Bacteria	S	Sulfatase-modifying factor enzyme 1	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase,Pkinase
CMS2_k127_56498_2	1499967.BAYZ01000039_gene2222	4.521e-81	276.0	COG0558@1|root,COG0558@2|Bacteria,2NPXW@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.34	ko:K07291	ko00562,map00562	-	R09670	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS2_k127_56498_7	645991.Sgly_0878	1.63e-34	149.0	COG5263@1|root,COG5263@2|Bacteria,1UYJ9@1239|Firmicutes,25KQ1@186801|Clostridia,26562@186807|Peptococcaceae	186801|Clostridia	N	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SLH
CMS2_k127_5654344_2	1379270.AUXF01000001_gene2303	1.344e-12	81.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1ZUB1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
CMS2_k127_5654344_4	1210884.HG799463_gene9711	1.875e-08	64.0	COG4249@1|root,COG4249@2|Bacteria,2IZ2A@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5654344_3	595460.RRSWK_02331	6.626e-11	75.0	2DBN7@1|root,2ZA2Y@2|Bacteria,2IYBW@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
CMS2_k127_5654344_0	1120950.KB892769_gene5438	7.355e-88	304.0	COG1835@1|root,COG1835@2|Bacteria,2HUMC@201174|Actinobacteria,4DW4W@85009|Propionibacteriales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
CMS2_k127_5654344_1	1249975.JQLP01000005_gene1651	8.487e-24	116.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP_2,Kelch_1,Laminin_G_3
CMS2_k127_5654344_5	525904.Tter_1092	2.154e-06	60.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_6,DUF1080,DUF1565,HemolysinCabind,PA14,SGL,ThuA,fn3
CMS2_k127_5677943_13	1396141.BATP01000057_gene3053	3.738e-40	157.0	COG2312@1|root,COG3209@1|root,COG2312@2|Bacteria,COG3209@2|Bacteria,46XD5@74201|Verrucomicrobia,2IVHX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Fn3_assoc,LTD
CMS2_k127_5677943_6	1396141.BATP01000003_gene4934	2.355e-131	460.0	COG2312@1|root,COG2312@2|Bacteria	2|Bacteria	S	response to antibiotic	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Erythro_esteras,LTD
CMS2_k127_5677943_16	756499.Desde_2564	1.421e-10	70.0	COG1309@1|root,COG1309@2|Bacteria,1VKYR@1239|Firmicutes,25B66@186801|Clostridia,26734@186807|Peptococcaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS2_k127_5677943_7	393921.HQ45_08520	6.775e-126	414.0	COG1509@1|root,COG1509@2|Bacteria,4NJ79@976|Bacteroidetes,2G2FM@200643|Bacteroidia,22WSW@171551|Porphyromonadaceae	976|Bacteroidetes	C	Lysine 2,3-aminomutase	ablA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
CMS2_k127_5677943_3	1121405.dsmv_1838	4.795e-180	581.0	COG0123@1|root,COG0454@1|root,COG0123@2|Bacteria,COG0456@2|Bacteria,1MU7P@1224|Proteobacteria,42NAQ@68525|delta/epsilon subdivisions,2WJPX@28221|Deltaproteobacteria,2MK5E@213118|Desulfobacterales	28221|Deltaproteobacteria	BKQ	Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Hist_deacetyl
CMS2_k127_5677943_9	1499967.BAYZ01000028_gene1264	2.656e-103	349.0	COG1181@1|root,COG1181@2|Bacteria,2NRF0@2323|unclassified Bacteria	2|Bacteria	M	ATP-grasp domain	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
CMS2_k127_5677943_10	530564.Psta_3376	1.38e-70	262.0	COG0454@1|root,COG1181@1|root,COG0456@2|Bacteria,COG1181@2|Bacteria,2IZEV@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
CMS2_k127_5677943_0	234267.Acid_2264	1.492e-231	729.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_2,PSCyt2,PSD1
CMS2_k127_5677943_4	497964.CfE428DRAFT_1966	7.936e-170	548.0	COG3119@1|root,COG3119@2|Bacteria,46V0M@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
CMS2_k127_5677943_2	234267.Acid_2265	5.599e-214	674.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS2_k127_5677943_1	234267.Acid_2266	2.741e-228	730.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,WD40
CMS2_k127_5677943_8	1185876.BN8_06489	1.014e-117	394.0	COG3250@1|root,COG3250@2|Bacteria,4NHRV@976|Bacteroidetes,47JP4@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolases family 2, TIM barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C
CMS2_k127_5677943_5	530564.Psta_3673	7.66e-168	544.0	COG2804@1|root,COG2804@2|Bacteria,2IYEE@203682|Planctomycetes	203682|Planctomycetes	NU	COG2804 Type II secretory pathway ATPase PulE Tfp pilus assembly pathway ATPase PilB	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
CMS2_k127_5677943_11	1210884.HG799465_gene12114	3.472e-70	253.0	COG1459@1|root,COG1459@2|Bacteria,2IXYZ@203682|Planctomycetes	203682|Planctomycetes	U	Type 4 fimbrial assembly protein pilC	-	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
CMS2_k127_5677943_15	373903.Hore_18680	1.163e-29	132.0	COG2165@1|root,COG2165@2|Bacteria,1UGS9@1239|Firmicutes,25PAU@186801|Clostridia,3WBR5@53433|Halanaerobiales	186801|Clostridia	NU	Type II secretion system (T2SS), protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
CMS2_k127_5677943_18	526222.Desal_0390	0.0001392	51.0	COG4970@1|root,COG4970@2|Bacteria,1NGHF@1224|Proteobacteria,4370U@68525|delta/epsilon subdivisions,2X1RK@28221|Deltaproteobacteria,2MFIK@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Pfam:N_methyl_2	-	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_5677943_17	1121434.AULY01000014_gene2713	7.521e-05	51.0	COG2165@1|root,COG2165@2|Bacteria,1NH8A@1224|Proteobacteria,43CDD@68525|delta/epsilon subdivisions,2X7P8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Prokaryotic N-terminal methylation motif	gspI	-	-	ko:K02458	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_5677943_19	269799.Gmet_3370	0.0003323	51.0	COG4795@1|root,COG4795@2|Bacteria	2|Bacteria	U	General secretion pathway protein	gspJ	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
CMS2_k127_5677943_14	530564.Psta_3667	7.477e-36	153.0	COG3156@1|root,COG3156@2|Bacteria,2IXHV@203682|Planctomycetes	203682|Planctomycetes	U	Type II secretion system (T2SS), protein K	-	-	-	-	-	-	-	-	-	-	-	-	T2SSK
CMS2_k127_5677943_12	661478.OP10G_4206	7.313e-50	204.0	COG1450@1|root,COG1450@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	gspD	-	-	ko:K02453,ko:K03219	ko03070,ko05111,map03070,map05111	M00331,M00332,M00542	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15,3.A.6.1,3.A.6.3	-	-	Secretin,Secretin_N
CMS2_k127_5725513_17	288000.BBta_3710	8.426e-36	145.0	COG2977@1|root,COG2977@2|Bacteria,1MZK2@1224|Proteobacteria,2U22J@28211|Alphaproteobacteria,3K0WT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	4'-phosphopantetheinyl transferase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ACPS
CMS2_k127_5725513_2	1173028.ANKO01000233_gene2454	1.364e-167	547.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H837@1150|Oscillatoriales	1117|Cyanobacteria	Q	Non-ribosomal peptide synthetase modules and related	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS2_k127_5725513_5	211165.AJLN01000149_gene6654	3.344e-121	419.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1JI65@1189|Stigonemataceae	1117|Cyanobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,TPR_1,TPR_8,Thioesterase
CMS2_k127_5725513_20	234267.Acid_4716	1.26e-22	105.0	COG1020@1|root,COG3882@1|root,COG1020@2|Bacteria,COG3882@2|Bacteria	2|Bacteria	Q	phosphopantetheine binding	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Condensation,Methyltransf_21,NAD_binding_4,PP-binding
CMS2_k127_5725513_27	321846.PS417_14945	5.111e-09	62.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1S4UG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_5725513_23	452637.Oter_4296	2.905e-20	93.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
CMS2_k127_5725513_12	160799.PBOR_11910	1.039e-64	244.0	COG0793@1|root,COG0793@2|Bacteria,1V2B2@1239|Firmicutes,4IBHM@91061|Bacilli,270GY@186822|Paenibacillaceae	91061|Bacilli	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
CMS2_k127_5725513_32	476272.RUMHYD_01285	0.0005006	48.0	2BW9N@1|root,32QZ7@2|Bacteria,1V8SR@1239|Firmicutes,24KPI@186801|Clostridia,3Y07T@572511|Blautia	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5725513_15	489825.LYNGBM3L_51560	2.144e-41	154.0	COG1073@1|root,COG1073@2|Bacteria,1GAUD@1117|Cyanobacteria,1HH12@1150|Oscillatoriales	1117|Cyanobacteria	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S9
CMS2_k127_5725513_28	304371.MCP_2060	5.152e-09	68.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5725513_24	292459.STH1451	3.223e-17	91.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia	186801|Clostridia	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS2_k127_5725513_30	414996.IL38_07640	5.964e-07	60.0	COG0438@1|root,COG0438@2|Bacteria,2GNR8@201174|Actinobacteria,408AD@622450|Actinopolysporales	201174|Actinobacteria	M	Glycosyl transferase 4-like	-	-	-	ko:K19424	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_5725513_26	1121422.AUMW01000010_gene1138	3.447e-13	79.0	COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,261PX@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS2_k127_5725513_18	1254432.SCE1572_06160	3.486e-32	144.0	COG1716@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbU	-	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315,ko:K16922	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01002,ko03021	-	-	-	CHASE2,FHA,GAF,GAF_2,HATPase_c_2,SpoIIE,Yop-YscD_cpl
CMS2_k127_5725513_6	635013.TherJR_0752	6.911e-120	405.0	COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,2498U@186801|Clostridia,2608U@186807|Peptococcaceae	186801|Clostridia	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
CMS2_k127_5725513_4	667014.Thein_2111	1.929e-136	456.0	COG3276@1|root,COG3276@2|Bacteria,2GH20@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
CMS2_k127_5725513_13	886293.Sinac_4157	2.977e-54	201.0	COG4233@1|root,COG4233@2|Bacteria,2J49W@203682|Planctomycetes	203682|Planctomycetes	CO	Disulphide bond corrector protein DsbC	-	-	-	-	-	-	-	-	-	-	-	-	DsbC
CMS2_k127_5725513_29	886293.Sinac_4157	1.184e-07	60.0	COG4233@1|root,COG4233@2|Bacteria,2J49W@203682|Planctomycetes	203682|Planctomycetes	CO	Disulphide bond corrector protein DsbC	-	-	-	-	-	-	-	-	-	-	-	-	DsbC
CMS2_k127_5725513_3	314230.DSM3645_23496	3.558e-163	526.0	COG3119@1|root,COG3119@2|Bacteria,2IXP1@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
CMS2_k127_5725513_25	1382306.JNIM01000001_gene3330	1.027e-16	87.0	2ACY3@1|root,312JQ@2|Bacteria,2G8H3@200795|Chloroflexi	200795|Chloroflexi	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
CMS2_k127_5725513_31	660470.Theba_1099	1.745e-05	55.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	3.4.24.3	ko:K01387	-	-	-	-	ko00000,ko01000,ko01002,ko02042	-	-	-	Peptidase_M9,Peptidase_M9_N
CMS2_k127_5725513_21	234267.Acid_7247	3.419e-21	99.0	COG1595@1|root,COG1595@2|Bacteria,3Y815@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_5725513_14	760568.Desku_2056	4.662e-46	175.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia,2626H@186807|Peptococcaceae	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
CMS2_k127_5725513_0	1079986.JH164837_gene5557	1.23e-298	942.0	COG3250@1|root,COG3250@2|Bacteria,2IF23@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolases family 2	-	-	-	-	-	-	-	-	-	-	-	-	Bgal_small_N,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
CMS2_k127_5725513_9	1499967.BAYZ01000040_gene2240	1.576e-70	246.0	COG4221@1|root,COG4221@2|Bacteria,2NPJV@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short
CMS2_k127_5725513_19	1120965.AUBV01000005_gene1736	3.097e-27	119.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CMS2_k127_5725513_22	1237149.C900_02571	3.931e-21	108.0	COG0666@1|root,COG0666@2|Bacteria,4NPMU@976|Bacteroidetes,47XI7@768503|Cytophagia	976|Bacteroidetes	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4,Ank_5
CMS2_k127_5725513_11	204669.Acid345_0040	3.555e-65	234.0	COG1475@1|root,COG1475@2|Bacteria,3Y40Y@57723|Acidobacteria,2JHJB@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
CMS2_k127_5725513_8	562970.Btus_2812	1.233e-116	385.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,4H9N2@91061|Bacilli,2797I@186823|Alicyclobacillaceae	91061|Bacilli	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CMS2_k127_5725513_7	1232410.KI421427_gene1286	1.55e-118	399.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2WJ80@28221|Deltaproteobacteria,43RYN@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
CMS2_k127_5725513_10	429009.Adeg_0594	2.178e-65	236.0	COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,42EVI@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM GTP cyclohydrolase I Nitrile oxidoreductase	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
CMS2_k127_5725513_16	1356854.N007_10880	1.519e-36	149.0	COG0720@1|root,COG0720@2|Bacteria,1UZVB@1239|Firmicutes,4H9SV@91061|Bacilli	91061|Bacilli	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
CMS2_k127_5725513_1	497964.CfE428DRAFT_1820	1.842e-190	603.0	COG1506@1|root,COG1506@2|Bacteria,46UJ0@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
CMS2_k127_573131_5	338963.Pcar_1472	2.597e-19	93.0	2DN2Z@1|root,32V89@2|Bacteria,1N3VG@1224|Proteobacteria,42TI7@68525|delta/epsilon subdivisions,2WQNX@28221|Deltaproteobacteria,43SPU@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-ribbon_3
CMS2_k127_573131_0	215803.DB30_3367	4.485e-68	264.0	COG4219@1|root,COG4219@2|Bacteria,1PJ0I@1224|Proteobacteria,4380Y@68525|delta/epsilon subdivisions,2X3AY@28221|Deltaproteobacteria,2YV6Q@29|Myxococcales	28221|Deltaproteobacteria	KT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
CMS2_k127_573131_1	1242864.D187_006336	4.697e-32	130.0	COG3682@1|root,COG3682@2|Bacteria,1RKDI@1224|Proteobacteria,4383A@68525|delta/epsilon subdivisions,2X3DA@28221|Deltaproteobacteria,2YVI8@29|Myxococcales	28221|Deltaproteobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS2_k127_573131_9	1123242.JH636435_gene1382	8.473e-15	89.0	COG1595@1|root,COG4219@1|root,COG1595@2|Bacteria,COG4219@2|Bacteria,2J1Q3@203682|Planctomycetes	203682|Planctomycetes	KT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
CMS2_k127_573131_6	318161.Sden_0578	5.171e-18	89.0	COG3682@1|root,COG3682@2|Bacteria,1RHX7@1224|Proteobacteria,1S5UV@1236|Gammaproteobacteria,2QC5H@267890|Shewanellaceae	1236|Gammaproteobacteria	K	Transcriptional repressor, CopY family	blaI	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS2_k127_573131_2	3847.GLYMA13G23240.1	4.61e-30	140.0	KOG1947@1|root,KOG1947@2759|Eukaryota,37ICC@33090|Viridiplantae,3G9ZF@35493|Streptophyta,4JMQP@91835|fabids	35493|Streptophyta	S	F-box LRR-repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LRR_5,LRR_6,LRR_8
CMS2_k127_573131_4	1210884.HG799471_gene14618	3.017e-23	118.0	COG0526@1|root,COG0526@2|Bacteria,2J147@203682|Planctomycetes	203682|Planctomycetes	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS2_k127_573131_8	1123242.JH636435_gene1382	7.746e-16	93.0	COG1595@1|root,COG4219@1|root,COG1595@2|Bacteria,COG4219@2|Bacteria,2J1Q3@203682|Planctomycetes	203682|Planctomycetes	KT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
CMS2_k127_573131_7	1192034.CAP_3244	4.095e-17	85.0	COG3682@1|root,COG3682@2|Bacteria,1RKDI@1224|Proteobacteria,4383A@68525|delta/epsilon subdivisions,2X3DA@28221|Deltaproteobacteria,2YVI8@29|Myxococcales	28221|Deltaproteobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS2_k127_5746968_7	192952.MM_2804	3.142e-16	79.0	arCOG03499@1|root,arCOG03499@2157|Archaea	2157|Archaea	G	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Disaggr_assoc,Disaggr_repeat,PKD
CMS2_k127_5746968_1	1499967.BAYZ01000076_gene808	4.477e-77	277.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
CMS2_k127_5746968_2	697281.Mahau_1310	1.142e-70	250.0	COG0329@1|root,COG0329@2|Bacteria,1TPSG@1239|Firmicutes,24H6N@186801|Clostridia,42I5K@68295|Thermoanaerobacterales	186801|Clostridia	EM	Belongs to the DapA family	-	-	4.1.3.16	ko:K18123	ko00330,ko00630,ko01100,map00330,map00630,map01100	-	R00470,R00471	RC00307,RC00308	ko00000,ko00001,ko01000	-	-	-	DHDPS
CMS2_k127_5746968_0	1123242.JH636435_gene1187	4.205e-272	852.0	COG0129@1|root,COG0129@2|Bacteria,2IYGE@203682|Planctomycetes	203682|Planctomycetes	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82	ko:K22396	ko00040,map00040	-	R02429	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
CMS2_k127_5746968_3	7739.XP_002599256.1	1.305e-20	108.0	KOG1215@1|root,KOG1215@2759|Eukaryota,38B6M@33154|Opisthokonta,3B9HR@33208|Metazoa	33208|Metazoa	T	lipoprotein receptor-related protein	-	-	-	ko:K03068,ko:K20051	ko04150,ko04310,ko05200,ko05224,ko05225,ko05226,map04150,map04310,map05200,map05224,map05225,map05226	-	-	-	ko00000,ko00001,ko04131	-	-	-	Ephrin_rec_like,FXa_inhibition,Ldl_recept_a,Ldl_recept_b
CMS2_k127_5746968_6	1216362.B437_08113	2.648e-16	89.0	28JJC@1|root,2Z9CF@2|Bacteria,379WK@32066|Fusobacteria	32066|Fusobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5746968_5	913865.DOT_5174	4.18e-17	85.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	DUF3795,OsmC
CMS2_k127_5746968_4	742159.HMPREF0004_0998	4.816e-18	87.0	2E3SC@1|root,32YPX@2|Bacteria,1N7IU@1224|Proteobacteria,2VWD1@28216|Betaproteobacteria,3T81Y@506|Alcaligenaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
CMS2_k127_5746968_8	518766.Rmar_1484	7.059e-16	88.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,Kelch_4
CMS2_k127_5759702_28	1293054.HSACCH_02341	1.275e-08	62.0	COG1345@1|root,COG1345@2|Bacteria,1TQ66@1239|Firmicutes,258DM@186801|Clostridia,3WB6Z@53433|Halanaerobiales	186801|Clostridia	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	-	-	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliD_C,FliD_N
CMS2_k127_5759702_15	42256.RradSPS_1174	6.717e-48	199.0	COG1216@1|root,COG4122@1|root,COG4641@1|root,COG1216@2|Bacteria,COG4122@2|Bacteria,COG4641@2|Bacteria,2IT06@201174|Actinobacteria	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
CMS2_k127_5759702_0	338966.Ppro_3338	0.0	1063.0	COG1032@1|root,COG1216@1|root,COG1032@2|Bacteria,COG1216@2|Bacteria,1RDAK@1224|Proteobacteria,42U4I@68525|delta/epsilon subdivisions,2WPIS@28221|Deltaproteobacteria,43V77@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	PFAM glycosyl transferase family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
CMS2_k127_5759702_26	526222.Desal_0572	3.252e-11	76.0	COG1861@1|root,COG2227@1|root,COG1861@2|Bacteria,COG2227@2|Bacteria,1N6SE@1224|Proteobacteria,4323F@68525|delta/epsilon subdivisions,2X84V@28221|Deltaproteobacteria,2M9SB@213115|Desulfovibrionales	28221|Deltaproteobacteria	HM	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_5759702_22	373994.Riv7116_5782	2.923e-20	105.0	COG0110@1|root,COG0110@2|Bacteria,1G2PV@1117|Cyanobacteria,1HIR6@1161|Nostocales	1117|Cyanobacteria	T	PFAM Bacterial transferase hexapeptide (three repeats)	-	-	2.3.1.18	ko:K00633	-	-	-	-	ko00000,ko01000	-	-	-	GAF_2,Hexapep,Hexapep_2
CMS2_k127_5759702_19	525897.Dbac_3025	7.799e-30	131.0	COG0457@1|root,COG0457@2|Bacteria,1REFJ@1224|Proteobacteria,42REI@68525|delta/epsilon subdivisions,2WN9F@28221|Deltaproteobacteria,2MB58@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_8
CMS2_k127_5759702_18	338966.Ppro_3338	5.68e-37	159.0	COG1032@1|root,COG1216@1|root,COG1032@2|Bacteria,COG1216@2|Bacteria,1RDAK@1224|Proteobacteria,42U4I@68525|delta/epsilon subdivisions,2WPIS@28221|Deltaproteobacteria,43V77@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	PFAM glycosyl transferase family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
CMS2_k127_5759702_16	518766.Rmar_2230	5.583e-43	176.0	COG0438@1|root,COG0457@1|root,COG2227@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG2227@2|Bacteria,4P78Y@976|Bacteroidetes	976|Bacteroidetes	H	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
CMS2_k127_5759702_25	1134413.ANNK01000032_gene1455	3.905e-13	81.0	COG1344@1|root,COG1344@2|Bacteria,1TPDT@1239|Firmicutes,4HCCZ@91061|Bacilli,1ZC4T@1386|Bacillus	91061|Bacilli	N	Belongs to the bacterial flagellin family	flgL	GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
CMS2_k127_5759702_7	1123242.JH636434_gene5074	8.12e-85	306.0	COG1256@1|root,COG1256@2|Bacteria,2IXRV@203682|Planctomycetes	203682|Planctomycetes	N	flagellar hook-associated protein	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
CMS2_k127_5759702_8	1123371.ATXH01000024_gene1011	2.524e-83	291.0	COG1706@1|root,COG1706@2|Bacteria,2GGRG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
CMS2_k127_5759702_21	1121439.dsat_2329	1.585e-22	105.0	COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,42MJW@68525|delta/epsilon subdivisions,2WMYI@28221|Deltaproteobacteria,2MB2X@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
CMS2_k127_5759702_31	1005995.GTPT_0929	1.04e-07	63.0	COG1261@1|root,COG1261@2|Bacteria	2|Bacteria	N	bacterial-type flagellum organization	flgA	-	-	ko:K02279,ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	ChapFlgA,SAF
CMS2_k127_5759702_6	237368.SCABRO_02734	3.261e-85	289.0	COG4786@1|root,COG4786@2|Bacteria,2IXW0@203682|Planctomycetes	203682|Planctomycetes	N	Flagellar basal body rod protein	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
CMS2_k127_5759702_20	909663.KI867150_gene1957	1.026e-29	127.0	COG4786@1|root,COG4786@2|Bacteria,1PZ24@1224|Proteobacteria,42NGI@68525|delta/epsilon subdivisions,2WMR8@28221|Deltaproteobacteria,2MS39@213462|Syntrophobacterales	28221|Deltaproteobacteria	N	Flagella basal body rod protein	flgF	-	-	ko:K02391,ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
CMS2_k127_5759702_9	1123242.JH636436_gene706	1.77e-77	281.0	COG1749@1|root,COG1749@2|Bacteria,2IYJT@203682|Planctomycetes	203682|Planctomycetes	N	Flagellar hook protein FlgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
CMS2_k127_5759702_23	666686.B1NLA3E_18280	2.768e-16	83.0	COG1843@1|root,COG1843@2|Bacteria,1VF85@1239|Firmicutes,4HNQK@91061|Bacilli,1ZI5S@1386|Bacillus	91061|Bacilli	N	Flagellar basal body rod modification protein	flgD	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgD
CMS2_k127_5759702_11	667014.Thein_1806	8.69e-74	266.0	COG2204@1|root,COG2204@2|Bacteria,2GHIR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_5759702_33	404589.Anae109_3402	0.0002297	55.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
CMS2_k127_5759702_4	589865.DaAHT2_1192	3.263e-90	317.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKG2@28221|Deltaproteobacteria,2MJ32@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	flbD	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_5759702_24	1123242.JH636434_gene3726	3.35e-14	82.0	COG1580@1|root,COG1580@2|Bacteria,2J0NS@203682|Planctomycetes	203682|Planctomycetes	N	Flagellar basal body-associated protein FliL	-	-	-	-	-	-	-	-	-	-	-	-	FliL
CMS2_k127_5759702_29	243274.THEMA_01270	6.659e-08	65.0	COG1868@1|root,COG1868@2|Bacteria,2GC39@200918|Thermotogae	200918|Thermotogae	N	flagellar motor switch protein FliM	fliM	GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0050896,GO:0050918	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
CMS2_k127_5759702_27	626887.J057_01319	6.457e-09	64.0	COG1886@1|root,COG1886@2|Bacteria,1RGWT@1224|Proteobacteria,1S5YE@1236|Gammaproteobacteria,467MM@72275|Alteromonadaceae	1236|Gammaproteobacteria	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliN	GO:0005575,GO:0005623,GO:0005886,GO:0009288,GO:0009425,GO:0016020,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0071944	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C,FliN_N
CMS2_k127_5759702_1	1210884.HG799466_gene12602	8.62e-171	560.0	COG1298@1|root,COG1298@2|Bacteria,2IXQ9@203682|Planctomycetes	203682|Planctomycetes	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	-	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
CMS2_k127_5759702_17	795359.TOPB45_1326	3.623e-37	151.0	COG1191@1|root,COG1191@2|Bacteria,2GHGC@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Sigma-70, region 4	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS2_k127_5759702_32	1210884.HG799473_gene15038	1.746e-07	62.0	2C991@1|root,32RNU@2|Bacteria,2J048@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5759702_10	317619.ANKN01000093_gene1936	2.066e-76	264.0	COG0670@1|root,COG0670@2|Bacteria,1G2GT@1117|Cyanobacteria	1117|Cyanobacteria	S	Belongs to the BI1 family	-	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
CMS2_k127_5759702_13	266117.Rxyl_2842	7.358e-62	219.0	COG0590@1|root,COG0590@2|Bacteria,2I9KR@201174|Actinobacteria	201174|Actinobacteria	FJ	CMP dCMP deaminase, zinc-binding	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
CMS2_k127_5759702_3	1112274.KI911560_gene1231	1.067e-93	329.0	COG1538@1|root,COG1538@2|Bacteria,1NEHN@1224|Proteobacteria,2VYWE@28216|Betaproteobacteria,2KKVJ@206350|Nitrosomonadales	206350|Nitrosomonadales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_5759702_12	575540.Isop_3019	4.821e-66	242.0	COG0577@1|root,COG0577@2|Bacteria,2IY2P@203682|Planctomycetes	203682|Planctomycetes	V	membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,FtsX,MacB_PCD
CMS2_k127_5759702_5	292459.STH976	8.14e-86	293.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia	186801|Clostridia	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_5759702_14	1379698.RBG1_1C00001G1364	1.422e-58	221.0	COG0845@1|root,COG0845@2|Bacteria,2NP97@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	macA	-	-	ko:K02005,ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP
CMS2_k127_5759702_2	1121904.ARBP01000013_gene349	1.489e-161	526.0	COG4948@1|root,COG4948@2|Bacteria,4NKNN@976|Bacteroidetes,47JKW@768503|Cytophagia	976|Bacteroidetes	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
CMS2_k127_5759702_30	342610.Patl_3855	9.988e-08	65.0	COG2982@1|root,COG2982@2|Bacteria,1P6EN@1224|Proteobacteria,1S1EC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
CMS2_k127_5790605_11	234267.Acid_4454	8.217e-09	56.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_5790605_2	1403819.BATR01000096_gene3164	2.467e-119	398.0	COG3356@1|root,COG3356@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5790605_0	344747.PM8797T_26205	0.0	1238.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	DUF1863,PQQ,PQQ_2,PQQ_3
CMS2_k127_5790605_6	502025.Hoch_2634	1.366e-82	283.0	COG0778@1|root,COG0778@2|Bacteria,1PG5G@1224|Proteobacteria,431RK@68525|delta/epsilon subdivisions,2WWKP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5790605_1	1396141.BATP01000057_gene3053	9.942e-205	678.0	COG2312@1|root,COG3209@1|root,COG2312@2|Bacteria,COG3209@2|Bacteria,46XD5@74201|Verrucomicrobia,2IVHX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Fn3_assoc,LTD
CMS2_k127_5790605_3	344747.PM8797T_30449	2.903e-92	315.0	294P7@1|root,2ZS2I@2|Bacteria,2J4KK@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5790605_10	1167006.UWK_00555	4.429e-34	143.0	COG3043@1|root,COG3043@2|Bacteria,1P0M5@1224|Proteobacteria,431MK@68525|delta/epsilon subdivisions,2WWRX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	anaerobic respiration	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5790605_4	717231.Flexsi_2010	6.329e-91	323.0	COG2864@1|root,COG2864@2|Bacteria,2GEJD@200930|Deferribacteres	200930|Deferribacteres	C	formate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5790605_8	589865.DaAHT2_2115	4.175e-43	179.0	COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,42NQM@68525|delta/epsilon subdivisions,2WK76@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
CMS2_k127_5790605_9	1167006.UWK_00558	3.654e-37	153.0	COG2864@1|root,COG2864@2|Bacteria,1PAKU@1224|Proteobacteria	1224|Proteobacteria	C	formate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5790605_7	1167006.UWK_00559	3.288e-61	224.0	COG3391@1|root,COG3391@2|Bacteria,1QWRQ@1224|Proteobacteria,42XKG@68525|delta/epsilon subdivisions,2WSNQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
CMS2_k127_5790605_5	667014.Thein_0391	7.569e-85	311.0	COG3005@1|root,COG3005@2|Bacteria,2GIDU@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Cytochrome c3	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS2_k127_5791847_4	1123508.JH636443_gene4909	6.401e-22	101.0	2BWMY@1|root,331GB@2|Bacteria,2J0M4@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5791847_0	903818.KI912269_gene107	1.168e-70	249.0	COG0646@1|root,COG0646@2|Bacteria,3Y7SY@57723|Acidobacteria	57723|Acidobacteria	E	Homocysteine S-methyltransferase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
CMS2_k127_5791847_2	335541.Swol_1076	7.545e-53	210.0	COG5492@1|root,COG5492@2|Bacteria,1V7TS@1239|Firmicutes,25F4B@186801|Clostridia,42KX4@68298|Syntrophomonadaceae	2|Bacteria	N	Surface proteins containing Ig-like domains-like	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CBM_X2,CHB_HEX_C_1,Flg_new,Glug,SLH
CMS2_k127_5791847_1	1236973.JCM9157_2869	5.739e-64	235.0	COG1835@1|root,COG1835@2|Bacteria,1UNRM@1239|Firmicutes,4IUMP@91061|Bacilli,1ZBMH@1386|Bacillus	91061|Bacilli	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
CMS2_k127_5791847_3	237368.SCABRO_03516	1.147e-26	113.0	COG1519@1|root,COG1519@2|Bacteria,2IYCJ@203682|Planctomycetes	203682|Planctomycetes	M	transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
CMS2_k127_5808638_3	1122239.AULS01000008_gene2431	5.363e-07	57.0	COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria	2|Bacteria	L	Transposase	tnp3514a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve
CMS2_k127_5808638_1	344747.PM8797T_17127	3.651e-70	256.0	COG1413@1|root,COG1413@2|Bacteria,2IYWU@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_5808638_2	1123322.KB904636_gene2696	6.49e-16	93.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	DUF4968,DUF5110,F5_F8_type_C,GH97_C,GH97_N,Glyco_hydro_31,Glyco_hydro_97,Melibiase_2,NPCBM,NPCBM_assoc
CMS2_k127_5808638_0	1211813.CAPH01000009_gene257	1.272e-130	448.0	COG3345@1|root,COG3345@2|Bacteria,4NZUR@976|Bacteroidetes,2FNUD@200643|Bacteroidia	976|Bacteroidetes	G	Melibiase	-	-	-	-	-	-	-	-	-	-	-	-	Melibiase
CMS2_k127_5824304_3	1255043.TVNIR_1924	2.993e-16	83.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WX5F@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
CMS2_k127_5824304_6	575540.Isop_1310	1.546e-06	59.0	COG2165@1|root,COG2165@2|Bacteria,2J3E1@203682|Planctomycetes	203682|Planctomycetes	NU	TIGRFAM prepilin-type N-terminal cleavage methylation domain	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_5824304_0	518766.Rmar_0827	3.081e-126	416.0	COG2355@1|root,COG2355@2|Bacteria,4NEBG@976|Bacteroidetes,1FJPW@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
CMS2_k127_5824304_2	592015.HMPREF1705_00686	3.372e-83	294.0	COG4690@1|root,COG4690@2|Bacteria,3TAN8@508458|Synergistetes	508458|Synergistetes	E	Dipeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
CMS2_k127_5824304_1	1209989.TepiRe1_2072	1.956e-114	385.0	COG1301@1|root,COG1301@2|Bacteria,1TPME@1239|Firmicutes,247UX@186801|Clostridia,42FVS@68295|Thermoanaerobacterales	186801|Clostridia	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	GltP	-	-	ko:K03309	-	-	-	-	ko00000	2.A.23	-	-	SDF
CMS2_k127_5824304_4	234267.Acid_6615	3.223e-10	72.0	28KX8@1|root,2ZAD8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5824304_5	1034769.KB910518_gene1041	6.262e-09	69.0	COG1621@1|root,COG3204@1|root,COG3533@1|root,COG3940@1|root,COG1621@2|Bacteria,COG3204@2|Bacteria,COG3533@2|Bacteria,COG3940@2|Bacteria,1U157@1239|Firmicutes,4HT9T@91061|Bacilli,26UV2@186822|Paenibacillaceae	91061|Bacilli	G	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,Laminin_G_3
CMS2_k127_5838016_2	243231.GSU2429	6.527e-43	173.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,42RVN@68525|delta/epsilon subdivisions,2WNJW@28221|Deltaproteobacteria,43SP4@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	SurA N-terminal domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
CMS2_k127_5838016_1	1121097.JCM15093_1551	2.605e-127	412.0	COG0363@1|root,COG0363@2|Bacteria,4NHF8@976|Bacteroidetes,2FN1D@200643|Bacteroidia,4AKMP@815|Bacteroidaceae	976|Bacteroidetes	G	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion	nagB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso
CMS2_k127_5838016_0	886379.AEWI01000026_gene438	1.289e-255	804.0	COG1208@1|root,COG1208@2|Bacteria,4NGYR@976|Bacteroidetes,2FMJ4@200643|Bacteroidia,3XJ22@558415|Marinilabiliaceae	976|Bacteroidetes	JM	Domain of unknown function (DUF4954)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4954
CMS2_k127_5838016_5	247490.KSU1_D0067	2.152e-07	61.0	COG1388@1|root,COG1388@2|Bacteria,2J2RB@203682|Planctomycetes	203682|Planctomycetes	M	Ami_2	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
CMS2_k127_5838016_3	870187.Thini_3673	5.69e-24	114.0	COG3012@1|root,COG3012@2|Bacteria,1P0F6@1224|Proteobacteria	1224|Proteobacteria	S	SEC-C Motif Domain Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5838016_4	377629.TERTU_2308	1.253e-18	90.0	COG4146@1|root,COG4146@2|Bacteria,1MXWV@1224|Proteobacteria,1RR4S@1236|Gammaproteobacteria,2PN6F@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	Sodium:solute symporter family	sglT	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_5883292_3	575540.Isop_0606	2.028e-50	189.0	COG1413@1|root,COG1413@2|Bacteria,2J0ZX@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_5883292_1	886293.Sinac_2714	7.087e-123	407.0	COG0673@1|root,COG0673@2|Bacteria,2IXFW@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5883292_0	575540.Isop_2477	4.909e-124	410.0	COG0673@1|root,COG0673@2|Bacteria,2IXFW@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_5883292_2	102125.Xen7305DRAFT_00020850	5.886e-73	256.0	COG3823@1|root,COG3823@2|Bacteria,1GPV5@1117|Cyanobacteria,3VMFK@52604|Pleurocapsales	1117|Cyanobacteria	O	Glutamine cyclotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_cyclase_2
CMS2_k127_5909091_0	1396418.BATQ01000041_gene6309	1.228e-121	409.0	COG0443@1|root,COG0443@2|Bacteria,46SDM@74201|Verrucomicrobia,2ITH0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	MreB/Mbl protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
CMS2_k127_5909091_1	488538.SAR116_1356	2.161e-23	114.0	COG3793@1|root,COG3793@2|Bacteria,1NS76@1224|Proteobacteria	1224|Proteobacteria	P	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
CMS2_k127_5912465_25	575540.Isop_2837	6.714e-23	99.0	COG0459@1|root,COG0459@2|Bacteria,2IXA7@203682|Planctomycetes	203682|Planctomycetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS2_k127_5912465_21	247490.KSU1_C0398	6.515e-36	138.0	COG0234@1|root,COG0234@2|Bacteria,2J027@203682|Planctomycetes	203682|Planctomycetes	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	-	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
CMS2_k127_5912465_31	886293.Sinac_6217	5.335e-09	63.0	COG2204@1|root,COG2204@2|Bacteria,2J0PB@203682|Planctomycetes	203682|Planctomycetes	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS2_k127_5912465_26	1116472.MGMO_60c00210	9.955e-22	103.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1XEK8@135618|Methylococcales	135618|Methylococcales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_5912465_4	768704.Desmer_1347	2.905e-129	451.0	COG2247@1|root,COG3391@1|root,COG2247@2|Bacteria,COG3391@2|Bacteria,1V2E4@1239|Firmicutes,24TKC@186801|Clostridia	186801|Clostridia	M	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
CMS2_k127_5912465_23	671143.DAMO_2920	7.878e-30	130.0	2DRSH@1|root,33CVS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5912465_1	886293.Sinac_4828	1.071e-176	564.0	COG0498@1|root,COG0498@2|Bacteria,2IXKE@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_5912465_28	269799.Gmet_3093	1.438e-16	86.0	2DPZI@1|root,3343T@2|Bacteria,1NPMI@1224|Proteobacteria,42XJN@68525|delta/epsilon subdivisions,2WTE9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5912465_14	1047013.AQSP01000140_gene2513	9.072e-58	214.0	COG1322@1|root,COG1322@2|Bacteria,2NPXU@2323|unclassified Bacteria	2|Bacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
CMS2_k127_5912465_30	7668.SPU_027444-tr	3.252e-14	81.0	COG1011@1|root,KOG3085@2759|Eukaryota,3AVXM@33154|Opisthokonta,3CNVC@33208|Metazoa,3E54N@33213|Bilateria	33208|Metazoa	S	Haloacid dehalogenase-like hydrolase	ACAD10	-	-	ko:K11729	-	-	-	-	ko00000	-	-	-	APH,HAD_2,Hydrolase
CMS2_k127_5912465_12	1009370.ALO_09369	1.916e-58	215.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,4H2GR@909932|Negativicutes	909932|Negativicutes	H	5-methyltetrahydrofolate--homocysteine methyltransferase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
CMS2_k127_5912465_7	317936.Nos7107_2910	2.232e-109	369.0	COG0531@1|root,COG0531@2|Bacteria,1G2GM@1117|Cyanobacteria,1HJCQ@1161|Nostocales	1117|Cyanobacteria	E	PFAM Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
CMS2_k127_5912465_10	1157490.EL26_21220	4.049e-80	278.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,4HA4N@91061|Bacilli,278Z3@186823|Alicyclobacillaceae	91061|Bacilli	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
CMS2_k127_5912465_20	243164.DET0661	4.828e-37	143.0	COG3118@1|root,COG3118@2|Bacteria,2G6U1@200795|Chloroflexi,34DD1@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Thioredoxin	trx	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS2_k127_5912465_27	1122138.AQUZ01000016_gene162	3.969e-18	93.0	COG1011@1|root,COG1011@2|Bacteria,2HZ7F@201174|Actinobacteria,4DQFA@85009|Propionibacteriales	201174|Actinobacteria	S	HAD-superfamily hydrolase, subfamily IA, variant 1	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase_like
CMS2_k127_5912465_2	203119.Cthe_3157	1.927e-171	548.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2495J@186801|Clostridia,3WGUB@541000|Ruminococcaceae	186801|Clostridia	E	Pyruvate carboxyltransferase	-	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0036440,GO:0046912,GO:0050450	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS03250	HMGL-like
CMS2_k127_5912465_32	1123058.KB894226_gene41	8.702e-05	45.0	COG0861@1|root,COG0861@2|Bacteria,4NFFD@976|Bacteroidetes,1HXRT@117743|Flavobacteriia	976|Bacteroidetes	P	membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
CMS2_k127_5912465_9	880072.Desac_2387	5.752e-82	291.0	COG4191@1|root,COG4191@2|Bacteria,1MY5P@1224|Proteobacteria,42MTA@68525|delta/epsilon subdivisions,2WJ9Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,CHASE3,HAMP,HATPase_c,HisKA
CMS2_k127_5912465_3	880072.Desac_2388	5.039e-154	501.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MRH1@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_5912465_17	272134.KB731324_gene2092	3.008e-48	182.0	2EMTG@1|root,33FFU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
CMS2_k127_5912465_29	96561.Dole_1087	2.247e-16	92.0	COG0457@1|root,COG1729@1|root,COG3914@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,42PJA@68525|delta/epsilon subdivisions,2WMG0@28221|Deltaproteobacteria,2MPUG@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Glycosyl transferase family 41	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_10,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8
CMS2_k127_5912465_15	637390.AFOH01000117_gene2810	3.812e-56	201.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,2NBQ5@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
CMS2_k127_5912465_24	237368.SCABRO_00432	3.996e-28	119.0	COG0613@1|root,COG0781@1|root,COG0613@2|Bacteria,COG0781@2|Bacteria,2J058@203682|Planctomycetes	203682|Planctomycetes	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB,PHP
CMS2_k127_5912465_8	314230.DSM3645_12121	2.206e-86	296.0	COG1192@1|root,COG1192@2|Bacteria,2IX5Z@203682|Planctomycetes	203682|Planctomycetes	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS2_k127_5912465_5	314230.DSM3645_25427	1.623e-116	382.0	COG0657@1|root,COG0657@2|Bacteria,2IY98@203682|Planctomycetes	203682|Planctomycetes	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
CMS2_k127_5912465_13	525904.Tter_1988	4.586e-58	227.0	COG3387@1|root,COG3387@2|Bacteria	2|Bacteria	G	glucan 1,4-alpha-glucosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_C
CMS2_k127_5912465_19	867902.Ornrh_1931	1.463e-39	156.0	COG0508@1|root,COG0508@2|Bacteria,4NFB9@976|Bacteroidetes,1HZ6M@117743|Flavobacteriia	976|Bacteroidetes	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CMS2_k127_5912465_0	927658.AJUM01000022_gene1031	5.253e-194	609.0	COG0524@1|root,COG0524@2|Bacteria,4NH8K@976|Bacteroidetes,2FM8P@200643|Bacteroidia,3XIZT@558415|Marinilabiliaceae	976|Bacteroidetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
CMS2_k127_5912465_22	338963.Pcar_2289	3.267e-33	133.0	2EHW5@1|root,33BMQ@2|Bacteria,1P29Q@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5912465_16	1142394.PSMK_22590	1.09e-53	213.0	COG1639@1|root,COG4191@1|root,COG1639@2|Bacteria,COG4191@2|Bacteria,2J037@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HDOD,HisKA
CMS2_k127_5912465_11	521674.Plim_2544	9.754e-69	237.0	COG0745@1|root,COG0745@2|Bacteria,2IY82@203682|Planctomycetes	203682|Planctomycetes	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Response_reg
CMS2_k127_5912465_6	251221.35211608	3.469e-113	383.0	COG1899@1|root,COG1899@2|Bacteria,1G448@1117|Cyanobacteria	1117|Cyanobacteria	O	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
CMS2_k127_5912465_18	521011.Mpal_2447	9.984e-45	167.0	COG0019@1|root,arCOG02268@2157|Archaea,2XYK2@28890|Euryarchaeota,2N9RB@224756|Methanomicrobia	224756|Methanomicrobia	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2177	Orn_Arg_deC_N,Orn_DAP_Arg_deC
CMS2_k127_5917988_0	589865.DaAHT2_1111	2.623e-139	458.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
CMS2_k127_5917988_1	1396141.BATP01000006_gene5432	2.89e-119	420.0	COG2312@1|root,COG2885@1|root,COG3209@1|root,COG3210@1|root,COG2312@2|Bacteria,COG2885@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,46XSC@74201|Verrucomicrobia,2IWGQ@203494|Verrucomicrobiae	2|Bacteria	M	CotH kinase protein	-	-	-	ko:K02487,ko:K12543	ko02020,map02020	M00330,M00507	-	-	ko00000,ko00001,ko00002,ko02000,ko02022,ko02035,ko02044	1.B.17,3.A.1.109.4	-	-	CotH,Erythro_esteras,LTD,OmpA
CMS2_k127_5917988_2	1396141.BATP01000019_gene1736	7.975e-21	109.0	COG2312@1|root,COG2312@2|Bacteria,46TMX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH,LTD
CMS2_k127_5956878_2	344747.PM8797T_03650	2.758e-176	566.0	COG2755@1|root,COG2755@2|Bacteria,2IWTR@203682|Planctomycetes	203682|Planctomycetes	E	sialic acid-specific 9-O-acetylesterase	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	SASA
CMS2_k127_5956878_6	1191523.MROS_0276	1.127e-46	179.0	COG0356@1|root,COG0356@2|Bacteria	2|Bacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
CMS2_k127_5956878_10	344747.PM8797T_28859	5.994e-12	69.0	COG0636@1|root,COG0636@2|Bacteria,2J0QD@203682|Planctomycetes	203682|Planctomycetes	P	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
CMS2_k127_5956878_8	886293.Sinac_6875	2.051e-18	92.0	COG0711@1|root,COG0711@2|Bacteria,2J0VZ@203682|Planctomycetes	203682|Planctomycetes	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
CMS2_k127_5956878_7	1051632.TPY_0809	1.242e-23	108.0	COG0712@1|root,COG0712@2|Bacteria,1VAG3@1239|Firmicutes,258WU@186801|Clostridia,3WDNF@538999|Clostridiales incertae sedis	186801|Clostridia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
CMS2_k127_5956878_1	344747.PM8797T_28844	1.707e-200	636.0	COG0056@1|root,COG0056@2|Bacteria,2IXN5@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
CMS2_k127_5956878_5	595460.RRSWK_04835	2.957e-49	188.0	COG0224@1|root,COG0224@2|Bacteria,2IXDI@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
CMS2_k127_5956878_0	530564.Psta_4413	2.019e-204	652.0	COG0055@1|root,COG0055@2|Bacteria,2IY7P@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
CMS2_k127_5956878_12	1142394.PSMK_08110	1.669e-09	66.0	COG0355@1|root,COG0355@2|Bacteria,2J00X@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
CMS2_k127_5956878_14	665571.STHERM_c03750	0.000314	48.0	COG0475@1|root,COG0517@1|root,COG0475@2|Bacteria,COG0517@2|Bacteria,2J5WC@203691|Spirochaetes	203691|Spirochaetes	P	Sodium hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Na_H_Exchanger
CMS2_k127_5956878_4	906968.Trebr_2386	7.018e-130	434.0	COG0475@1|root,COG0475@2|Bacteria,2J5WC@203691|Spirochaetes	203691|Spirochaetes	P	Sodium hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Na_H_Exchanger
CMS2_k127_5956878_11	314230.DSM3645_30041	1.491e-11	72.0	COG0594@1|root,COG0594@2|Bacteria,2J0QW@203682|Planctomycetes	203682|Planctomycetes	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
CMS2_k127_5956878_13	1688.BCUN_0459	3.504e-08	59.0	COG0789@1|root,COG0789@2|Bacteria,2HZI3@201174|Actinobacteria,4D0I1@85004|Bifidobacteriales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
CMS2_k127_5956878_9	530564.Psta_2134	6.48e-15	86.0	COG1463@1|root,COG1463@2|Bacteria,2IZS7@203682|Planctomycetes	203682|Planctomycetes	Q	ABC-type transport system involved in resistance to organic solvents periplasmic component	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
CMS2_k127_5956878_3	314230.DSM3645_01936	4.954e-168	535.0	COG3119@1|root,COG3119@2|Bacteria,2IXH3@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_5991855_13	1121918.ARWE01000001_gene2516	2e-54	198.0	COG1132@1|root,COG1132@2|Bacteria,1QXPT@1224|Proteobacteria	1224|Proteobacteria	V	Pfam ABC	-	-	-	ko:K02068	-	M00211	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
CMS2_k127_5991855_6	1121918.ARWE01000001_gene2515	1.227e-87	301.0	COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,42RYA@68525|delta/epsilon subdivisions,2WNM0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Uncharacterised protein family (UPF0014)	-	-	-	ko:K02069	-	M00211	-	-	ko00000,ko00002,ko02000	9.B.25.1	-	-	UPF0014
CMS2_k127_5991855_8	1307759.JOMJ01000003_gene1654	8.249e-81	291.0	COG3121@1|root,COG3121@2|Bacteria,1NSS2@1224|Proteobacteria	1224|Proteobacteria	NU	Chaperone	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5991855_17	459349.CLOAM0561	5.307e-08	67.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,FlgD_ig,PPC,VCBS,fn3
CMS2_k127_5991855_12	903818.KI912268_gene2810	5.237e-61	242.0	COG3210@1|root,COG4412@1|root,COG3210@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	-	ko:K20276,ko:K21449	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	1.B.40.2	-	-	Big_2,CARDB,Cadherin-like,Peptidase_M30,SLH,fn3
CMS2_k127_5991855_9	1307759.JOMJ01000003_gene1655	1.635e-73	282.0	COG4796@1|root,COG4796@2|Bacteria,1QUY7@1224|Proteobacteria,43D2U@68525|delta/epsilon subdivisions,2X8A0@28221|Deltaproteobacteria,2MHEC@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Secretin and TonB N terminus short domain	-	-	-	-	-	-	-	-	-	-	-	-	Secretin
CMS2_k127_5991855_1	562970.Btus_2805	3.11e-197	637.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,4HA1D@91061|Bacilli,2783I@186823|Alicyclobacillaceae	91061|Bacilli	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
CMS2_k127_5991855_5	1121468.AUBR01000026_gene2918	5.541e-90	310.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,42F0T@68295|Thermoanaerobacterales	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
CMS2_k127_5991855_3	1168034.FH5T_19355	3.626e-137	451.0	COG1387@1|root,COG1387@2|Bacteria,4NMBC@976|Bacteroidetes,2FNU7@200643|Bacteroidia	976|Bacteroidetes	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_5991855_10	246194.CHY_1873	2.858e-69	248.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,42F13@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM peptidase M24	pepP	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
CMS2_k127_5991855_14	351016.RAZWK3B_20066	6.968e-31	136.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,2P1PW@2433|Roseobacter	28211|Alphaproteobacteria	S	membrane protein (homolog of Drosophila rhomboid)	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS2_k127_5991855_16	756272.Plabr_4525	1.099e-12	80.0	2E5SS@1|root,330H5@2|Bacteria,2J0J5@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_5991855_4	1168034.FH5T_07485	3.065e-109	363.0	COG3622@1|root,COG3622@2|Bacteria,4NG74@976|Bacteroidetes	976|Bacteroidetes	G	PFAM Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
CMS2_k127_5991855_2	518766.Rmar_1734	5.403e-157	506.0	COG0673@1|root,COG0673@2|Bacteria,4NFMS@976|Bacteroidetes,1FJ32@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_5991855_0	886293.Sinac_5129	2.487e-225	705.0	COG4948@1|root,COG4948@2|Bacteria,2IXK2@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C
CMS2_k127_5991855_11	1123508.JH636439_gene811	5.049e-68	240.0	COG1082@1|root,COG1082@2|Bacteria,2IXX4@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_5991855_7	314230.DSM3645_25644	6.152e-84	287.0	COG0673@1|root,COG0673@2|Bacteria,2IYB5@203682|Planctomycetes	203682|Planctomycetes	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_6030067_6	237368.SCABRO_02468	1.176e-17	87.0	COG2010@1|root,COG2010@2|Bacteria,2J4DD@203682|Planctomycetes	203682|Planctomycetes	C	Domain of unknown function (DUF4405)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4405
CMS2_k127_6030067_2	452637.Oter_1849	1.948e-51	204.0	COG1595@1|root,COG1595@2|Bacteria,46SEW@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_6030067_1	1210884.HG799464_gene10601	1.534e-84	284.0	COG1403@1|root,COG1403@2|Bacteria,2IXXW@203682|Planctomycetes	203682|Planctomycetes	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
CMS2_k127_6030067_5	428127.EUBDOL_00197	2.253e-22	100.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,3VRNH@526524|Erysipelotrichia	526524|Erysipelotrichia	K	Cold-shock DNA-binding domain protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CMS2_k127_6030067_4	1142394.PSMK_24200	2.161e-28	117.0	COG0776@1|root,COG0776@2|Bacteria,2J01P@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the bacterial histone-like protein family	-	-	-	ko:K03530,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS2_k127_6030067_3	344747.PM8797T_11911	1.047e-49	197.0	COG0681@1|root,COG0681@2|Bacteria,2IY6X@203682|Planctomycetes	203682|Planctomycetes	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
CMS2_k127_6030067_0	653045.Strvi_3198	2.371e-164	544.0	COG3250@1|root,COG3250@2|Bacteria,2I3FI@201174|Actinobacteria	201174|Actinobacteria	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,NPCBM_assoc
CMS2_k127_60583_4	1267533.KB906737_gene1677	3.338e-77	275.0	COG0457@1|root,COG0457@2|Bacteria,3Y4J2@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF5107)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5107
CMS2_k127_60583_3	573413.Spirs_0830	1.437e-85	296.0	COG0059@1|root,COG0059@2|Bacteria,2J60P@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
CMS2_k127_60583_0	1303518.CCALI_00676	1.019e-215	697.0	COG3533@1|root,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
CMS2_k127_60583_6	234267.Acid_6615	1.424e-10	72.0	28KX8@1|root,2ZAD8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_60583_1	1210884.HG799471_gene14621	1.093e-132	443.0	COG2041@1|root,COG2041@2|Bacteria	2|Bacteria	V	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
CMS2_k127_60583_5	555779.Dthio_PD1267	1.485e-51	195.0	COG0667@1|root,COG0667@2|Bacteria,1R77F@1224|Proteobacteria,42Y4Z@68525|delta/epsilon subdivisions,2WTTZ@28221|Deltaproteobacteria,2MCP4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS2_k127_60583_2	1396418.BATQ01000109_gene4730	1.359e-94	328.0	COG0673@1|root,COG0673@2|Bacteria,46TMZ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_6067399_8	547042.BACCOPRO_01279	2.098e-20	104.0	COG2407@1|root,COG2407@2|Bacteria,4P1BT@976|Bacteroidetes,2FMIE@200643|Bacteroidia,4AKFB@815|Bacteroidaceae	976|Bacteroidetes	G	COG2407 L-fucose isomerase and related	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6067399_7	1235835.C814_02225	8.6e-29	122.0	COG5485@1|root,COG5485@2|Bacteria,1V4VN@1239|Firmicutes,24IWY@186801|Clostridia	186801|Clostridia	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
CMS2_k127_6067399_2	697281.Mahau_2746	3.58e-185	594.0	COG5520@1|root,COG5520@2|Bacteria	2|Bacteria	M	Belongs to the glycosyl hydrolase 30 family	-	-	3.2.1.136,3.2.1.55,3.2.1.8	ko:K01181,ko:K15921,ko:K15924	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	CBM6,GH43,GH5	-	Beta_helix,Binary_toxB_2,Binary_toxB_3,CBM_6,CW_binding_1,Dockerin_1,Glyco_hydro_10,Glyco_hydro_30,Glyco_hydro_30C,Glyco_hydro_43,Lipase_GDSL_2,RicinB_lectin_2,Ricin_B_lectin
CMS2_k127_6067399_5	1396141.BATP01000047_gene3974	1.167e-64	238.0	COG4299@1|root,COG4299@2|Bacteria,46XJK@74201|Verrucomicrobia,2IW2Y@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF5009)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5009
CMS2_k127_6067399_0	1122194.AUHU01000003_gene2343	1.371e-259	819.0	COG1554@1|root,COG1554@2|Bacteria,1QBJK@1224|Proteobacteria	1224|Proteobacteria	G	hydrolase, family 65, central catalytic	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6067399_1	926556.Echvi_1657	1.881e-251	792.0	COG5297@1|root,COG5297@2|Bacteria,4PKPX@976|Bacteroidetes,47NGZ@768503|Cytophagia	976|Bacteroidetes	G	Fg-gap repeat	-	-	4.2.2.23	ko:K18197	-	-	-	-	ko00000,ko01000	-	PL11	-	-
CMS2_k127_6067399_3	1121904.ARBP01000055_gene491	2.306e-81	276.0	COG2984@1|root,COG2984@2|Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
CMS2_k127_6067399_10	913865.DOT_2772	3.76e-06	54.0	COG3668@1|root,COG3668@2|Bacteria,1VHZU@1239|Firmicutes,2549A@186801|Clostridia	186801|Clostridia	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
CMS2_k127_6067399_4	314230.DSM3645_17981	2.368e-69	262.0	COG2304@1|root,COG2304@2|Bacteria,2IY1T@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA,VWA_3
CMS2_k127_6067399_6	459349.CLOAM0984	1.912e-34	136.0	COG1361@1|root,COG1361@2|Bacteria,2NS3P@2323|unclassified Bacteria	2|Bacteria	M	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FlgD_ig,Peptidase_C25,Peptidase_C25_C,Propeptide_C25
CMS2_k127_6123573_3	59374.Fisuc_2717	2.143e-79	273.0	COG1696@1|root,COG1696@2|Bacteria	2|Bacteria	M	negative regulation of protein lipidation	algI	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
CMS2_k127_6123573_5	59374.Fisuc_2588	3.512e-48	188.0	2C7PP@1|root,33K9Q@2|Bacteria	2|Bacteria	S	SGNH hydrolase-like domain, acetyltransferase AlgX	-	-	-	ko:K19295	-	-	-	-	ko00000	-	-	-	ALGX
CMS2_k127_6123573_1	1499967.BAYZ01000077_gene869	2.647e-131	431.0	COG0246@1|root,COG0246@2|Bacteria,2NQX9@2323|unclassified Bacteria	2|Bacteria	G	Mannitol dehydrogenase Rossmann domain	mtlD	-	1.1.1.17	ko:K00009	ko00051,map00051	-	R02703	RC00085	ko00000,ko00001,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
CMS2_k127_6123573_2	1340493.JNIF01000004_gene476	3.532e-129	424.0	COG4948@1|root,COG4948@2|Bacteria,3Y2UE@57723|Acidobacteria	57723|Acidobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
CMS2_k127_6123573_0	448385.sce0958	9.029e-210	696.0	COG0574@1|root,COG0574@2|Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
CMS2_k127_6123573_10	192952.MM_1119	6.977e-10	72.0	arCOG03500@1|root,arCOG03500@2157|Archaea	2157|Archaea	P	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	Disaggr_assoc
CMS2_k127_6123573_7	335543.Sfum_2158	1.069e-14	88.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
CMS2_k127_6123573_4	118168.MC7420_6956	4.551e-51	205.0	COG4886@1|root,COG4886@2|Bacteria,1G4SR@1117|Cyanobacteria,1HAQW@1150|Oscillatoriales	1117|Cyanobacteria	G	Leucine-rich repeat	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	LRR_4,LRR_6,LRR_8
CMS2_k127_6123573_9	192952.MM_1119	1.422e-11	78.0	arCOG03500@1|root,arCOG03500@2157|Archaea	2157|Archaea	P	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	Disaggr_assoc
CMS2_k127_6123573_11	634498.mru_0084	0.0001406	55.0	arCOG02488@1|root,arCOG02554@1|root,arCOG02555@1|root,arCOG02488@2157|Archaea,arCOG02554@2157|Archaea,arCOG02555@2157|Archaea,2Y1R0@28890|Euryarchaeota	634498.mru_0084|-	E	Glycoside hydrolase family 28	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6123573_6	370438.PTH_2805	1.393e-24	120.0	COG4886@1|root,COG4886@2|Bacteria,1V3UH@1239|Firmicutes,24K2H@186801|Clostridia	186801|Clostridia	E	leucine-rich repeat-containing protein typical subtype	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_4,DUF5050,LRR_4
CMS2_k127_6123573_8	192952.MM_1144	2.566e-14	80.0	COG5563@1|root,arCOG03499@1|root,arCOG03499@2157|Archaea,arCOG03501@2157|Archaea	2157|Archaea	S	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Disaggr_assoc,Disaggr_repeat,PKD
CMS2_k127_6132851_9	1121423.JONT01000002_gene2329	3.436e-08	66.0	COG1409@1|root,COG1409@2|Bacteria,1VTEB@1239|Firmicutes,24E3Z@186801|Clostridia	186801|Clostridia	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS2_k127_6132851_8	237368.SCABRO_03912	3.958e-24	107.0	COG2331@1|root,COG2331@2|Bacteria,2J0TW@203682|Planctomycetes	203682|Planctomycetes	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
CMS2_k127_6132851_7	1033734.CAET01000069_gene2349	1.964e-29	126.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli,1ZGCW@1386|Bacillus	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
CMS2_k127_6132851_4	530564.Psta_3026	1.153e-117	389.0	COG0484@1|root,COG0484@2|Bacteria,2IXQJ@203682|Planctomycetes	203682|Planctomycetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
CMS2_k127_6132851_0	237368.SCABRO_03915	5.413e-215	681.0	COG0459@1|root,COG0459@2|Bacteria,2IXJW@203682|Planctomycetes	203682|Planctomycetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS2_k127_6132851_6	429009.Adeg_0160	1.849e-31	125.0	COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,24MMM@186801|Clostridia,42GV4@68295|Thermoanaerobacterales	186801|Clostridia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
CMS2_k127_6132851_2	1121904.ARBP01000023_gene4987	2.111e-184	587.0	COG2755@1|root,COG3669@1|root,COG2755@2|Bacteria,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,47KQM@768503|Cytophagia	976|Bacteroidetes	G	Alpha-L-fucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Alpha_L_fucos,Fucosidase_C
CMS2_k127_6132851_3	1303518.CCALI_00327	3.211e-171	556.0	COG3669@1|root,COG3669@2|Bacteria	2|Bacteria	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Fucosidase_C
CMS2_k127_6132851_1	1379698.RBG1_1C00001G0289	2.557e-203	647.0	COG0459@1|root,COG0459@2|Bacteria,2NNM6@2323|unclassified Bacteria	2|Bacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016465,GO:0018995,GO:0020003,GO:0023051,GO:0023056,GO:0030430,GO:0032991,GO:0033643,GO:0033646,GO:0033655,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0051082,GO:0061077,GO:0065007,GO:0065010,GO:0101031,GO:1901222,GO:1901224,GO:1902531,GO:1902533,GO:1990220,GO:2000535	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS2_k127_6132851_5	177437.HRM2_10340	1.191e-97	328.0	COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,42R3P@68525|delta/epsilon subdivisions,2WMVW@28221|Deltaproteobacteria,2MJGY@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Phospholipase A1	-	-	3.1.1.32,3.1.1.4	ko:K01058	ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110	-	R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko01000	-	-	-	PLA1
CMS2_k127_6133729_6	530564.Psta_0986	2.843e-17	94.0	2CIQF@1|root,32S8C@2|Bacteria,2J094@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6133729_3	742738.HMPREF9460_00523	2.449e-84	291.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,24NIH@186801|Clostridia,269X0@186813|unclassified Clostridiales	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_6133729_1	180332.JTGN01000003_gene2001	9.154e-116	386.0	COG0407@1|root,COG0407@2|Bacteria,1V5JE@1239|Firmicutes,24E5A@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
CMS2_k127_6133729_4	180332.JTGN01000022_gene1511	2.231e-66	243.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,24G9W@186801|Clostridia	186801|Clostridia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_6133729_0	1195236.CTER_2031	5.071e-136	446.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24G9G@186801|Clostridia	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_6133729_5	269799.Gmet_1908	3.413e-66	229.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,42SK2@68525|delta/epsilon subdivisions,2WPB3@28221|Deltaproteobacteria,43URW@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
CMS2_k127_6133729_2	886293.Sinac_7534	8.81e-107	361.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6133729_7	886293.Sinac_6601	1.339e-07	60.0	COG1595@1|root,COG3170@1|root,COG1595@2|Bacteria,COG3170@2|Bacteria,2J20Z@203682|Planctomycetes	203682|Planctomycetes	KNU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_613451_4	1296990.H845_3433	8.514e-07	52.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2U0ZH@28211|Alphaproteobacteria,2JU7J@204441|Rhodospirillales	204441|Rhodospirillales	L	DDE (Asp,Asp,Glu) domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
CMS2_k127_613451_0	886293.Sinac_4372	6.734e-59	213.0	COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
CMS2_k127_613451_1	1499967.BAYZ01000049_gene2749	1.056e-33	151.0	COG3405@1|root,COG4625@1|root,COG3405@2|Bacteria,COG4625@2|Bacteria	2|Bacteria	T	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CHU_C,Laminin_G_3,Malectin,PA14
CMS2_k127_613451_3	1210884.HG799465_gene12178	9.447e-20	96.0	COG1595@1|root,COG1595@2|Bacteria,2J0XE@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_613451_2	1274524.BSONL12_04374	3.838e-20	101.0	2E2AR@1|root,32XG5@2|Bacteria,1VHHN@1239|Firmicutes	1239|Firmicutes	S	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	AP2,HNH_3
CMS2_k127_6152849_2	908612.HMPREF9720_2719	1.934e-99	337.0	COG2025@1|root,COG2025@2|Bacteria,4NFSE@976|Bacteroidetes,2FMEK@200643|Bacteroidia	976|Bacteroidetes	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
CMS2_k127_6152849_0	247490.KSU1_D0522	1.22e-180	578.0	COG0215@1|root,COG0215@2|Bacteria,2IX9C@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
CMS2_k127_6152849_6	237368.SCABRO_00865	1.469e-24	108.0	COG1895@1|root,COG1895@2|Bacteria,2J4E4@203682|Planctomycetes	203682|Planctomycetes	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_6152849_5	1173264.KI913949_gene3161	3.239e-26	111.0	COG1669@1|root,COG1669@2|Bacteria,1G7T8@1117|Cyanobacteria	1117|Cyanobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CMS2_k127_6152849_4	1437824.BN940_05186	1.809e-45	173.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,2VR7F@28216|Betaproteobacteria,3T3SA@506|Alcaligenaceae	28216|Betaproteobacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
CMS2_k127_6152849_3	247490.KSU1_C0301	7.528e-65	227.0	COG0131@1|root,COG0131@2|Bacteria,2IYU4@203682|Planctomycetes	203682|Planctomycetes	E	imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
CMS2_k127_6152849_1	1173027.Mic7113_4125	1.161e-108	362.0	COG0079@1|root,COG0079@2|Bacteria,1FZV3@1117|Cyanobacteria,1H9BZ@1150|Oscillatoriales	1117|Cyanobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iJN678.hisC	Aminotran_1_2
CMS2_k127_6181521_2	706587.Desti_3416	1.022e-31	128.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WQ7I@28221|Deltaproteobacteria,2MS9G@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS2_k127_6181521_1	269799.Gmet_1908	8.211e-62	216.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,42SK2@68525|delta/epsilon subdivisions,2WPB3@28221|Deltaproteobacteria,43URW@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
CMS2_k127_6181521_3	1123368.AUIS01000030_gene1245	3.915e-12	73.0	COG1846@1|root,COG1846@2|Bacteria,1RF8X@1224|Proteobacteria,1S4RW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
CMS2_k127_6181521_0	545264.KB898757_gene2483	0.0	1612.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,1WXFY@135613|Chromatiales	135613|Chromatiales	G	Glycosyltransferase 36 associated	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
CMS2_k127_6192296_4	452637.Oter_1853	6.956e-31	132.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_6192296_5	1123288.SOV_6c00620	4.162e-25	115.0	2E2AR@1|root,32XG5@2|Bacteria,1VHHN@1239|Firmicutes,4H9J4@909932|Negativicutes	909932|Negativicutes	S	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_3
CMS2_k127_6192296_3	1340493.JNIF01000004_gene1065	3.471e-50	193.0	COG3940@1|root,COG3940@2|Bacteria	2|Bacteria	G	arabinan catabolic process	-	-	3.2.1.97	ko:K17624	-	-	-	-	ko00000,ko01000	-	GH101	-	Big_4,Glyco_hydro_43,Laminin_G_3
CMS2_k127_6192296_1	886293.Sinac_4612	7.53e-105	347.0	2BZ6M@1|root,2Z7HW@2|Bacteria,2IXV4@203682|Planctomycetes	203682|Planctomycetes	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_6192296_2	452637.Oter_3509	3.476e-70	244.0	COG0673@1|root,COG0673@2|Bacteria,46TMZ@74201|Verrucomicrobia,3K8Y2@414999|Opitutae	414999|Opitutae	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_6192296_0	1121468.AUBR01000020_gene2853	2.839e-132	431.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,42EWI@68295|Thermoanaerobacterales	186801|Clostridia	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS15750	ALAD
CMS2_k127_6192296_6	886293.Sinac_0921	0.0001422	45.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	3.2.1.18,3.2.1.4	ko:K01179,ko:K01186	ko00500,ko00511,ko00600,ko01100,ko04142,map00500,map00511,map00600,map01100,map04142	-	R04018,R06200,R11307,R11308	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33,GH5,GH9	-	BNR,BNR_2,CBM_2,RicinB_lectin_2
CMS2_k127_6196485_0	452637.Oter_3025	1.163e-100	334.0	COG0684@1|root,COG0684@2|Bacteria,46VAD@74201|Verrucomicrobia,3K8HM@414999|Opitutae	414999|Opitutae	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
CMS2_k127_6196485_4	404589.Anae109_1680	3.258e-13	82.0	COG0823@1|root,COG3266@1|root,COG4447@1|root,COG5640@1|root,COG0823@2|Bacteria,COG3266@2|Bacteria,COG4447@2|Bacteria,COG5640@2|Bacteria,1QZXX@1224|Proteobacteria	1224|Proteobacteria	U	endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6196485_2	96561.Dole_1791	1.043e-41	180.0	COG1044@1|root,COG1361@1|root,COG1653@1|root,COG1044@2|Bacteria,COG1361@2|Bacteria,COG1653@2|Bacteria,1N4S6@1224|Proteobacteria,43BRE@68525|delta/epsilon subdivisions,2X729@28221|Deltaproteobacteria,2MNRP@213118|Desulfobacterales	1224|Proteobacteria	G	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6196485_1	388467.A19Y_3529	1.043e-41	180.0	COG4932@1|root,COG4932@2|Bacteria,1G0MJ@1117|Cyanobacteria,1H9HP@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Collagen-binding surface protein Cna-like, B-type domain	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B,Trypsin
CMS2_k127_6196485_5	1043493.BBLU01000008_gene479	5.09e-12	81.0	COG1361@1|root,COG2304@1|root,COG2911@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,Tape_meas_lam_C,VWA,VWA_2
CMS2_k127_6196485_3	411154.GFO_1836	1.575e-19	106.0	COG1520@1|root,COG2304@1|root,COG2911@1|root,COG3209@1|root,COG1520@2|Bacteria,COG2304@2|Bacteria,COG2911@2|Bacteria,COG3209@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ7S@117743|Flavobacteriia	976|Bacteroidetes	M	SPTR CHU large protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,HYR,SprB
CMS2_k127_6197364_9	997346.HMPREF9374_0646	3.599e-13	79.0	2AH2Y@1|root,33C1P@2|Bacteria,1W1Q1@1239|Firmicutes	997346.HMPREF9374_0646|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6197364_2	1489678.RDMS_12985	2.547e-73	258.0	COG1230@1|root,COG1230@2|Bacteria	2|Bacteria	P	cation diffusion facilitator family transporter	zitB	GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	iNRG857_1313.NRG857_03325,iPC815.YPO1129	Cation_efflux,ZT_dimer
CMS2_k127_6197364_4	1304880.JAGB01000002_gene1910	4.987e-72	248.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia	186801|Clostridia	S	TIGRFAM methyltransferase cognate corrinoid proteins, Methanosarcina family	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
CMS2_k127_6197364_1	886293.Sinac_0515	3.698e-88	317.0	COG0568@1|root,COG0568@2|Bacteria,2IY72@203682|Planctomycetes	203682|Planctomycetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03086,ko:K03093	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
CMS2_k127_6197364_3	269797.Mbar_A1879	9.482e-73	252.0	COG0730@1|root,arCOG06728@2157|Archaea,2XZCP@28890|Euryarchaeota,2NB0J@224756|Methanomicrobia	224756|Methanomicrobia	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS2_k127_6197364_7	429009.Adeg_0382	5.855e-16	86.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,42J0Y@68295|Thermoanaerobacterales	186801|Clostridia	S	flavin reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
CMS2_k127_6197364_5	223283.PSPTO_5047	9.52e-55	202.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1Z5SR@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	iSBO_1134.SBO_0282,ic_1306.c0493	F420_oxidored,P5CR_dimer
CMS2_k127_6197364_0	1379281.AVAG01000031_gene106	1.522e-219	693.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,2M8WP@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	iAF987.Gmet_3512	Aldedh,Pro_dh
CMS2_k127_6197364_8	1125712.HMPREF1316_0200	8.44e-14	74.0	COG1141@1|root,COG1141@2|Bacteria,2GWHY@201174|Actinobacteria,4CYD7@84998|Coriobacteriia	84998|Coriobacteriia	C	4Fe-4S single cluster domain of Ferredoxin I	fdx	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
CMS2_k127_6224934_5	756272.Plabr_3194	1.446e-09	69.0	COG1680@1|root,COG1680@2|Bacteria,2IX14@203682|Planctomycetes	203682|Planctomycetes	V	COG1680 Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_6224934_4	1123008.KB905708_gene1016	1.346e-20	104.0	COG2006@1|root,COG2006@2|Bacteria,4NH1F@976|Bacteroidetes,2FP1X@200643|Bacteroidia,22X7D@171551|Porphyromonadaceae	976|Bacteroidetes	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,TAT_signal
CMS2_k127_6224934_0	243090.RB4667	2.009e-131	433.0	COG1520@1|root,COG1520@2|Bacteria	243090.RB4667|-	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6224934_8	999411.HMPREF1092_01232	0.0008199	48.0	COG4974@1|root,COG4974@2|Bacteria,1UTX8@1239|Firmicutes,24DFG@186801|Clostridia,36E3B@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_int_SAM_5,Phage_integrase
CMS2_k127_6224934_7	1158318.ATXC01000001_gene673	3.012e-05	50.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_5,Phage_integrase
CMS2_k127_6224934_3	97096.XP_007792908.1	1.296e-27	133.0	COG0666@1|root,KOG0504@2759|Eukaryota,39YNX@33154|Opisthokonta,3Q68T@4751|Fungi,3RP7R@4890|Ascomycota	4751|Fungi	S	Ankyrin repeat	-	-	-	ko:K21440	-	-	-	-	ko00000,ko04131	-	-	-	Ank_2,Ank_4
CMS2_k127_6224934_1	1122179.KB890454_gene2961	8.868e-76	292.0	COG0666@1|root,COG4219@1|root,COG0666@2|Bacteria,COG4219@2|Bacteria,4NKKC@976|Bacteroidetes,1INTG@117747|Sphingobacteriia	976|Bacteroidetes	KT	PFAM Peptidase M56, BlaR1	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
CMS2_k127_6224934_2	530564.Psta_1920	9.69e-44	163.0	COG3682@1|root,COG3682@2|Bacteria,2J0D9@203682|Planctomycetes	203682|Planctomycetes	K	penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS2_k127_6224934_6	1095769.CAHF01000010_gene1156	1.519e-08	64.0	COG1506@1|root,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2VN0X@28216|Betaproteobacteria,474WV@75682|Oxalobacteraceae	28216|Betaproteobacteria	EU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS2_k127_622923_5	756272.Plabr_3887	1.603e-40	151.0	COG1520@1|root,COG1520@2|Bacteria,2IX03@203682|Planctomycetes	203682|Planctomycetes	S	protein kinase related protein	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_622923_8	96561.Dole_0165	8.316e-32	128.0	COG3070@1|root,COG3070@2|Bacteria,1N8X8@1224|Proteobacteria,433D2@68525|delta/epsilon subdivisions,2WY7H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	TfoX N-terminal domain	-	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
CMS2_k127_622923_7	179408.Osc7112_1843	3.221e-32	128.0	2DNRM@1|root,32YT2@2|Bacteria,1G8FD@1117|Cyanobacteria,1HD5I@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
CMS2_k127_622923_11	1278073.MYSTI_07406	1.281e-19	93.0	COG1682@1|root,COG1682@2|Bacteria,1QXTH@1224|Proteobacteria,42XN1@68525|delta/epsilon subdivisions,2WSPR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CMS2_k127_622923_2	926561.KB900617_gene1296	7.432e-93	319.0	COG0820@1|root,COG0820@2|Bacteria,1TPVF@1239|Firmicutes,248BC@186801|Clostridia,3WA63@53433|Halanaerobiales	186801|Clostridia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
CMS2_k127_622923_10	28444.JODQ01000007_gene5741	1.397e-24	115.0	COG1105@1|root,COG1105@2|Bacteria,2GK7E@201174|Actinobacteria,4EHTI@85012|Streptosporangiales	201174|Actinobacteria	G	pfkB family carbohydrate kinase	fruK	-	2.7.1.56	ko:K00882	ko00051,map00051	-	R02071	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CMS2_k127_622923_13	1408473.JHXO01000003_gene2584	5.48e-19	99.0	2E676@1|root,330VQ@2|Bacteria,4PA7N@976|Bacteroidetes,2FZJU@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_622923_1	575540.Isop_3095	1.666e-113	379.0	COG1207@1|root,COG1207@2|Bacteria,2IXXB@203682|Planctomycetes	203682|Planctomycetes	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
CMS2_k127_622923_0	237368.SCABRO_01903	4.206e-116	388.0	COG0462@1|root,COG0462@2|Bacteria,2IXI0@203682|Planctomycetes	203682|Planctomycetes	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
CMS2_k127_622923_6	886293.Sinac_0831	2.675e-37	149.0	COG1825@1|root,COG1825@2|Bacteria,2J050@203682|Planctomycetes	203682|Planctomycetes	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
CMS2_k127_622923_3	1347086.CCBA010000016_gene497	2.08e-50	185.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,4HH2Z@91061|Bacilli,1ZC7I@1386|Bacillus	91061|Bacilli	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
CMS2_k127_622923_12	575540.Isop_2891	2.46e-19	94.0	COG0360@1|root,COG0360@2|Bacteria,2J0U0@203682|Planctomycetes	203682|Planctomycetes	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
CMS2_k127_622923_4	237368.SCABRO_01907	1.015e-40	155.0	COG0629@1|root,COG0629@2|Bacteria,2IZJ8@203682|Planctomycetes	203682|Planctomycetes	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
CMS2_k127_622923_14	575540.Isop_1027	8.05e-16	80.0	COG0238@1|root,COG0238@2|Bacteria,2J0IC@203682|Planctomycetes	203682|Planctomycetes	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
CMS2_k127_622923_9	589865.DaAHT2_1150	3.245e-25	112.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2WPZQ@28221|Deltaproteobacteria,2MJFS@213118|Desulfobacterales	28221|Deltaproteobacteria	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
CMS2_k127_622923_15	1535287.JP74_20770	4.919e-13	78.0	2DMII@1|root,32RTH@2|Bacteria,1QW8Y@1224|Proteobacteria,2TWTF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
CMS2_k127_622923_17	760192.Halhy_1586	0.0009656	49.0	COG2931@1|root,COG2931@2|Bacteria,4NKF1@976|Bacteroidetes,1IVE6@117747|Sphingobacteriia	976|Bacteroidetes	Q	A domain in the BMP inhibitor chordin and in microbial proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,SusE
CMS2_k127_625236_5	1291050.JAGE01000001_gene2546	1.446e-44	177.0	COG5492@1|root,COG5492@2|Bacteria,1VZGP@1239|Firmicutes,24GSA@186801|Clostridia	186801|Clostridia	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_625236_0	1120966.AUBU01000005_gene3785	7.866e-187	600.0	COG0405@1|root,COG0405@2|Bacteria,4NF2H@976|Bacteroidetes,47K06@768503|Cytophagia	976|Bacteroidetes	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CMS2_k127_625236_4	1336243.JAEA01000001_gene1830	1.171e-74	284.0	COG4625@1|root,COG4625@2|Bacteria,1MU92@1224|Proteobacteria,2TSB7@28211|Alphaproteobacteria,1JTT8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	U	TIGRFAM outer membrane autotransporter barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,PATR
CMS2_k127_625236_2	1499967.BAYZ01000076_gene806	2.618e-111	365.0	COG1028@1|root,COG1028@2|Bacteria,2NQY3@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
CMS2_k127_625236_3	1267535.KB906767_gene3349	9.326e-102	341.0	COG1063@1|root,COG1063@2|Bacteria,3Y6II@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS2_k127_625236_1	344747.PM8797T_20758	3.618e-131	435.0	COG2610@1|root,COG2610@2|Bacteria,2J1TI@203682|Planctomycetes	203682|Planctomycetes	EG	COG2610 H gluconate symporter and related permeases	-	-	-	-	-	-	-	-	-	-	-	-	GntP_permease
CMS2_k127_625236_6	575540.Isop_2667	3.155e-17	83.0	COG4287@1|root,COG4287@2|Bacteria,2IYKE@203682|Planctomycetes	203682|Planctomycetes	S	PhoPQ-activated pathogenicity-related protein	-	-	-	-	-	-	-	-	-	-	-	-	PhoPQ_related
CMS2_k127_6253329_2	1453505.JASY01000006_gene1259	1.145e-08	68.0	COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,1I0G9@117743|Flavobacteriia,2NTFA@237|Flavobacterium	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6253329_0	1168034.FH5T_08475	1.18e-30	140.0	COG2133@1|root,COG2911@1|root,COG3227@1|root,COG2133@2|Bacteria,COG2911@2|Bacteria,COG3227@2|Bacteria	2|Bacteria	E	Zinc metalloprotease (Elastase)	-	-	-	-	-	-	-	-	-	-	-	-	MAM,PATR,Peptidase_M43,fn3
CMS2_k127_6253329_1	1089548.KI783301_gene2047	3.624e-30	139.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.1.1.11	ko:K01051	ko00040,ko01100,map00040,map01100	M00081	R02362	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	CBM_6,Cadherin,DUF1929,HemolysinCabind,Malectin,Metallophos,PA14,Pur_ac_phosph_N
CMS2_k127_6273350_1	1123242.JH636436_gene303	3.413e-77	271.0	COG0768@1|root,COG0768@2|Bacteria,2IXEK@203682|Planctomycetes	203682|Planctomycetes	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
CMS2_k127_6273350_3	338963.Pcar_2842	1.122e-46	183.0	COG0707@1|root,COG0707@2|Bacteria,1MWQP@1224|Proteobacteria,42R9T@68525|delta/epsilon subdivisions,2WMWQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_3
CMS2_k127_6273350_4	632518.Calow_1095	8.177e-41	173.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia,42FN0@68295|Thermoanaerobacterales	186801|Clostridia	M	Penicillin-binding protein, dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
CMS2_k127_6273350_5	1123514.KB905899_gene1535	2.379e-11	74.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,460NI@72273|Thiotrichales	72273|Thiotrichales	M	Involved in formation and maintenance of cell shape	-	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
CMS2_k127_6273350_0	1142394.PSMK_14530	9.656e-157	501.0	COG1077@1|root,COG1077@2|Bacteria,2IXSJ@203682|Planctomycetes	203682|Planctomycetes	D	COG1077 Actin-like ATPase involved in cell morphogenesis	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
CMS2_k127_6273350_6	756272.Plabr_1950	4.575e-11	74.0	COG1413@1|root,COG3391@1|root,COG1413@2|Bacteria,COG3391@2|Bacteria,2IXTT@203682|Planctomycetes	203682|Planctomycetes	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS2_k127_6273350_2	247490.KSU1_C0172	1.133e-60	232.0	COG0815@1|root,COG0815@2|Bacteria,2IWUW@203682|Planctomycetes	203682|Planctomycetes	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
CMS2_k127_6278951_1	644282.Deba_1938	8.498e-177	565.0	COG2848@1|root,COG2848@2|Bacteria,1NAFG@1224|Proteobacteria,42NH7@68525|delta/epsilon subdivisions,2WJJM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
CMS2_k127_6278951_14	1226322.HMPREF1545_02447	1.374e-16	82.0	COG3830@1|root,COG3830@2|Bacteria,1VENW@1239|Firmicutes,24QNV@186801|Clostridia,2N7MG@216572|Oscillospiraceae	186801|Clostridia	T	ACT domain	-	-	-	ko:K07166	-	-	-	-	ko00000	-	-	-	ACT_6
CMS2_k127_6278951_8	886293.Sinac_0010	1.648e-50	199.0	COG0496@1|root,COG0496@2|Bacteria,2IXPI@203682|Planctomycetes	203682|Planctomycetes	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
CMS2_k127_6278951_7	1123242.JH636435_gene2389	9.154e-52	192.0	COG0062@1|root,COG0062@2|Bacteria,2IZU6@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX	nnrE	-	5.1.99.6	ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	YjeF_N
CMS2_k127_6278951_12	530564.Psta_3786	2.485e-18	99.0	COG3064@1|root,COG3064@2|Bacteria,2IZM5@203682|Planctomycetes	203682|Planctomycetes	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6278951_9	1267580.AF6_2545	8.964e-40	159.0	COG0546@1|root,COG0546@2|Bacteria,1UKM3@1239|Firmicutes,4ITJK@91061|Bacilli	91061|Bacilli	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CMS2_k127_6278951_6	1089553.Tph_c02040	3.582e-53	201.0	COG0382@1|root,COG0382@2|Bacteria,1TRTB@1239|Firmicutes,24AQ0@186801|Clostridia,42G1D@68295|Thermoanaerobacterales	186801|Clostridia	H	UbiA prenyltransferase family	ubiA	-	-	-	-	-	-	-	-	-	-	-	UbiA
CMS2_k127_6278951_5	555079.Toce_1148	6.122e-65	229.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,42G4B@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS2_k127_6278951_4	349741.Amuc_1932	2.524e-67	243.0	COG0251@1|root,COG0251@2|Bacteria,46V5Y@74201|Verrucomicrobia,2IW47@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
CMS2_k127_6278951_15	344747.PM8797T_18951	4.144e-13	71.0	2EGPU@1|root,32K36@2|Bacteria,2J1G1@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6278951_13	886293.Sinac_7434	2.43e-17	91.0	2BR4A@1|root,32K29@2|Bacteria,2J1BQ@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6278951_0	344747.PM8797T_18941	1.418e-265	830.0	COG2192@1|root,COG2192@2|Bacteria,2IYCS@203682|Planctomycetes	203682|Planctomycetes	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS2_k127_6278951_11	1210884.HG799463_gene10266	1.171e-21	97.0	COG0227@1|root,COG0227@2|Bacteria,2J0SS@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
CMS2_k127_6278951_10	316067.Geob_0380	1.641e-28	119.0	COG0721@1|root,COG0721@2|Bacteria,1QE6H@1224|Proteobacteria,42VPR@68525|delta/epsilon subdivisions,2WRP0@28221|Deltaproteobacteria,43V4D@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	iAF987.Gmet_0076	Glu-tRNAGln
CMS2_k127_6278951_3	756272.Plabr_2090	1.092e-82	285.0	COG4099@1|root,COG4099@2|Bacteria,2IZGT@203682|Planctomycetes	203682|Planctomycetes	P	Phospholipase/Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	DLH,Peptidase_S9
CMS2_k127_6278951_2	575540.Isop_2925	7.385e-97	325.0	COG0154@1|root,COG0154@2|Bacteria,2IXW5@203682|Planctomycetes	203682|Planctomycetes	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS2_k127_63028_3	1396141.BATP01000023_gene685	5.848e-78	272.0	COG1913@1|root,COG1913@2|Bacteria,46WX0@74201|Verrucomicrobia,2IVPQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Peptidase family M54	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M54
CMS2_k127_63028_5	631454.N177_2495	6.314e-62	224.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,1JNV9@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
CMS2_k127_63028_4	1267535.KB906767_gene3433	1.129e-64	229.0	COG1595@1|root,COG1595@2|Bacteria,3Y8YQ@57723|Acidobacteria	57723|Acidobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_63028_0	1123242.JH636434_gene3495	6.916e-179	607.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
CMS2_k127_63028_6	397948.Cmaq_1106	4.234e-11	68.0	COG2407@1|root,arCOG01772@2157|Archaea	2157|Archaea	G	L-fucose isomerase and related	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_63028_1	1079460.ATTQ01000012_gene2520	7.319e-102	340.0	COG0454@1|root,COG0456@2|Bacteria,1PKGA@1224|Proteobacteria,2UQ1Q@28211|Alphaproteobacteria,4BJ59@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_63028_2	1123242.JH636434_gene4078	6.503e-88	298.0	COG0500@1|root,COG2226@2|Bacteria,2IXEP@203682|Planctomycetes	203682|Planctomycetes	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
CMS2_k127_6304373_3	59374.Fisuc_2002	2.49e-08	67.0	COG3866@1|root,COG4733@1|root,COG3866@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Laminin_G_3,fn3
CMS2_k127_6304373_4	742766.HMPREF9455_00332	0.0003997	53.0	COG0383@1|root,COG0383@2|Bacteria,4NGF5@976|Bacteroidetes,2FRK9@200643|Bacteroidia,22Z81@171551|Porphyromonadaceae	976|Bacteroidetes	G	Glycosyl hydrolases family 38 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_38,Glyco_hydro_38C
CMS2_k127_6304373_2	1122925.KB895385_gene3064	4.419e-39	167.0	COG3507@1|root,COG3533@1|root,COG3507@2|Bacteria,COG3533@2|Bacteria,1U157@1239|Firmicutes,4HT9T@91061|Bacilli,26UV2@186822|Paenibacillaceae	91061|Bacilli	G	Concanavalin A-like lectin/glucanases superfamily	M1-853	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS2_k127_6304373_1	886293.Sinac_3844	1.369e-107	377.0	COG0457@1|root,COG2755@1|root,COG0457@2|Bacteria,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N,Lipase_GDSL_2,SLH,TPR_16,TPR_19,fn3
CMS2_k127_6304373_0	1210884.HG799462_gene7993	4.117e-165	534.0	COG0457@1|root,COG0457@2|Bacteria,2IZEP@203682|Planctomycetes	1210884.HG799462_gene7993|-	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6327325_0	404589.Anae109_2903	8.622e-254	803.0	COG0574@1|root,COG0574@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2Z1W9@29|Myxococcales	28221|Deltaproteobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
CMS2_k127_6327325_1	1499967.BAYZ01000102_gene3556	1.207e-213	679.0	COG0826@1|root,COG0826@2|Bacteria,2NPQH@2323|unclassified Bacteria	2|Bacteria	O	Evidence 5 No homology to any previously reported sequences	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
CMS2_k127_6327325_4	1123371.ATXH01000004_gene1774	6.971e-35	143.0	COG1648@1|root,COG1648@2|Bacteria,2GH09@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Sirohaem biosynthesis protein central	-	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
CMS2_k127_6327325_2	1125863.JAFN01000001_gene1785	3.734e-66	229.0	COG1838@1|root,COG1838@2|Bacteria,1RCSV@1224|Proteobacteria,42NRW@68525|delta/epsilon subdivisions,2X5RX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Hydro-lyase, Fe-S type, tartrate fumarate subfamily, beta subunit	-	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
CMS2_k127_6327325_3	880073.Calab_1856	8.006e-57	210.0	COG0012@1|root,COG0012@2|Bacteria,2NNNF@2323|unclassified Bacteria	2|Bacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
CMS2_k127_6331778_14	1448860.BBJO01000002_gene2054	4.283e-12	75.0	COG3291@1|root,arCOG02483@1|root,arCOG02483@2157|Archaea,arCOG02546@2157|Archaea,2Y7ZF@28890|Euryarchaeota,24143@183963|Halobacteria	183963|Halobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
CMS2_k127_6331778_16	105422.BBPM01000102_gene5263	7.821e-05	53.0	COG4409@1|root,COG4934@1|root,COG4409@2|Bacteria,COG4934@2|Bacteria,2GN94@201174|Actinobacteria,2NEQG@228398|Streptacidiphilus	201174|Actinobacteria	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
CMS2_k127_6331778_7	1166948.JPZL01000002_gene1178	4.861e-64	229.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,1RMZB@1236|Gammaproteobacteria,1XIKH@135619|Oceanospirillales	135619|Oceanospirillales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
CMS2_k127_6331778_0	886293.Sinac_0952	3.68e-145	481.0	COG1335@1|root,COG3828@1|root,COG1335@2|Bacteria,COG3828@2|Bacteria,2IX7K@203682|Planctomycetes	203682|Planctomycetes	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase,ThuA
CMS2_k127_6331778_11	1123508.JH636449_gene7300	5.227e-27	119.0	COG1595@1|root,COG1595@2|Bacteria,2IZ91@203682|Planctomycetes	203682|Planctomycetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_6331778_4	395493.BegalDRAFT_1262	9.96e-125	424.0	COG5316@1|root,COG5316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
CMS2_k127_6331778_9	886293.Sinac_0056	1.209e-50	198.0	COG1595@1|root,COG1595@2|Bacteria,2J3QA@203682|Planctomycetes	2|Bacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_6331778_5	395493.BegalDRAFT_1263	1.281e-116	388.0	COG5316@1|root,COG5316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
CMS2_k127_6331778_1	395493.BegalDRAFT_1262	9.083e-139	455.0	COG5316@1|root,COG5316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
CMS2_k127_6331778_3	395493.BegalDRAFT_1262	2.171e-131	436.0	COG5316@1|root,COG5316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
CMS2_k127_6331778_10	1168034.FH5T_12675	1.967e-44	177.0	2CI12@1|root,338T1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6331778_15	706587.Desti_1487	2.241e-08	66.0	2EGD2@1|root,33A4V@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
CMS2_k127_6331778_2	547042.BACCOPRO_00992	6.861e-133	451.0	COG1572@1|root,COG1572@2|Bacteria,4PJMZ@976|Bacteroidetes,2FZ9J@200643|Bacteroidia	976|Bacteroidetes	S	Domain of unknown function (DUF4091)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4091
CMS2_k127_6331778_12	1045855.DSC_01600	1.827e-23	104.0	COG1725@1|root,COG1725@2|Bacteria,1N23D@1224|Proteobacteria,1S9NK@1236|Gammaproteobacteria,1X74P@135614|Xanthomonadales	135614|Xanthomonadales	K	transcriptional	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS2_k127_6331778_8	1123508.JH636440_gene2061	4.859e-56	208.0	COG1131@1|root,COG1131@2|Bacteria,2IZVY@203682|Planctomycetes	203682|Planctomycetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_6331778_13	1173028.ANKO01000117_gene5934	1.994e-13	72.0	COG2442@1|root,COG2442@2|Bacteria	2|Bacteria	K	InterPro IPR007367	-	-	-	-	-	-	-	-	-	-	-	-	DUF433,MerR_1
CMS2_k127_6331778_6	247490.KSU1_C0054	2.52e-74	257.0	COG2231@1|root,COG2231@2|Bacteria,2IZ9A@203682|Planctomycetes	203682|Planctomycetes	L	endonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
CMS2_k127_6354730_2	247490.KSU1_C1031	1.131e-139	454.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2IZRY@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
CMS2_k127_6354730_0	247490.KSU1_B0142	1.388e-181	572.0	COG1830@1|root,COG1830@2|Bacteria,2IWUP@203682|Planctomycetes	203682|Planctomycetes	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
CMS2_k127_6354730_3	908612.HMPREF9720_0153	5.248e-115	386.0	COG0297@1|root,COG0297@2|Bacteria,4PKP8@976|Bacteroidetes,2G0CZ@200643|Bacteroidia,22UN6@171550|Rikenellaceae	976|Bacteroidetes	G	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glyco_transf_5,Glycos_transf_1
CMS2_k127_6354730_1	563192.HMPREF0179_03201	1.713e-168	538.0	COG1449@1|root,COG1449@2|Bacteria,1R8JX@1224|Proteobacteria,42QA5@68525|delta/epsilon subdivisions,2WMM5@28221|Deltaproteobacteria,2M9GJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	3.2.1.1	ko:K07405	ko00500,ko01100,map00500,map01100	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH57	-	Glyco_hydro_57
CMS2_k127_6354730_5	497964.CfE428DRAFT_4925	5.678e-05	57.0	COG5426@1|root,COG5426@2|Bacteria	2|Bacteria	D	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6354730_6	391009.Tmel_1008	0.0001299	55.0	COG2374@1|root,COG4085@1|root,COG2374@2|Bacteria,COG4085@2|Bacteria,2GCXZ@200918|Thermotogae	200918|Thermotogae	S	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
CMS2_k127_6354730_4	497964.CfE428DRAFT_4925	6.763e-09	70.0	COG5426@1|root,COG5426@2|Bacteria	2|Bacteria	D	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6372330_12	1262914.BN533_01621	1.914e-07	53.0	COG5561@1|root,COG5561@2|Bacteria,1VE2W@1239|Firmicutes,4H7NX@909932|Negativicutes	909932|Negativicutes	S	CGGC domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CGGC
CMS2_k127_6372330_10	697281.Mahau_2035	5.135e-13	79.0	COG0796@1|root,COG0796@2|Bacteria	2|Bacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Glu_race
CMS2_k127_6372330_11	525904.Tter_1998	5.782e-10	72.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	BACON,CW_binding_1,Cellulase,Collagen_bind_2,DUF4038,DUF5060
CMS2_k127_6372330_4	742733.HMPREF9469_00981	8.731e-58	216.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,222G9@1506553|Lachnoclostridium	186801|Clostridia	G	Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS2_k127_6372330_6	65393.PCC7424_2206	4.219e-24	105.0	COG4634@1|root,COG4634@2|Bacteria,1G86P@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C
CMS2_k127_6372330_5	221288.JH992901_gene5377	2.427e-24	104.0	COG2442@1|root,COG2442@2|Bacteria,1G9UJ@1117|Cyanobacteria,1JM6U@1189|Stigonemataceae	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
CMS2_k127_6372330_3	1121428.DESHY_110537___1	5.546e-63	229.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
CMS2_k127_6372330_7	397948.Cmaq_0229	8.62e-23	113.0	COG2407@1|root,arCOG01772@2157|Archaea	2157|Archaea	G	L-fucose isomerase and related	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6372330_0	344747.PM8797T_20758	1.183e-135	449.0	COG2610@1|root,COG2610@2|Bacteria,2J1TI@203682|Planctomycetes	203682|Planctomycetes	EG	COG2610 H gluconate symporter and related permeases	-	-	-	-	-	-	-	-	-	-	-	-	GntP_permease
CMS2_k127_6372330_2	1232449.BAHV02000008_gene670	3.747e-97	328.0	COG0176@1|root,COG0176@2|Bacteria,1U9RA@1239|Firmicutes,24DCI@186801|Clostridia	186801|Clostridia	H	PFAM Transaldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
CMS2_k127_6372330_9	257310.BB1546	1.396e-14	87.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2VIWM@28216|Betaproteobacteria,3T7N5@506|Alcaligenaceae	28216|Betaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
CMS2_k127_6372330_8	1408473.JHXO01000002_gene3784	2.002e-20	106.0	COG5512@1|root,COG5512@2|Bacteria,4NHWD@976|Bacteroidetes,2FP0N@200643|Bacteroidia	976|Bacteroidetes	S	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
CMS2_k127_6372330_1	192952.MM_2787	3.989e-123	408.0	arCOG03315@1|root,arCOG03315@2157|Archaea,2Y2NW@28890|Euryarchaeota,2NACC@224756|Methanomicrobia	224756|Methanomicrobia	S	DUF3160	-	-	-	-	-	-	-	-	-	-	-	-	DUF3160
CMS2_k127_6390729_5	926549.KI421517_gene3731	8.258e-30	126.0	COG0823@1|root,COG2885@1|root,COG3063@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,COG3063@2|Bacteria,4NE6G@976|Bacteroidetes,47MTM@768503|Cytophagia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
CMS2_k127_6390729_2	398525.KB900701_gene2983	3.573e-69	253.0	COG2159@1|root,COG2159@2|Bacteria,1ND2I@1224|Proteobacteria,2UIP1@28211|Alphaproteobacteria,3K498@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
CMS2_k127_6390729_1	314230.DSM3645_20627	9.629e-133	442.0	COG1520@1|root,COG1520@2|Bacteria,2IWR8@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_6390729_4	1246626.BleG1_0544	9.356e-42	167.0	COG1621@1|root,COG1621@2|Bacteria,1UBHH@1239|Firmicutes,4IMWU@91061|Bacilli,1ZM1R@1386|Bacillus	91061|Bacilli	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6390729_3	1380600.AUYN01000009_gene1077	2.39e-58	219.0	COG2133@1|root,COG2133@2|Bacteria,4NF61@976|Bacteroidetes	976|Bacteroidetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS2_k127_6390729_0	56780.SYN_02504	6.233e-155	499.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,42P7C@68525|delta/epsilon subdivisions,2WKKF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM MltA domain protein	-	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
CMS2_k127_6419819_0	344747.PM8797T_06060	2.134e-129	428.0	COG0673@1|root,COG0673@2|Bacteria,2IXJ0@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_6419819_3	1142394.PSMK_24200	3.133e-23	102.0	COG0776@1|root,COG0776@2|Bacteria,2J01P@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the bacterial histone-like protein family	-	-	-	ko:K03530,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS2_k127_6419819_2	118173.KB235914_gene3829	2.131e-33	146.0	2DBP2@1|root,2ZA71@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6419819_1	1246459.KB898355_gene4106	1.601e-50	187.0	COG1082@1|root,COG1082@2|Bacteria,1N1AK@1224|Proteobacteria,2U3TU@28211|Alphaproteobacteria,4BB6Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_6419819_4	1122239.AULS01000008_gene2431	2.38e-09	63.0	COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria	2|Bacteria	L	Transposase	tnp3514a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve
CMS2_k127_642458_4	1123276.KB893259_gene2518	2.458e-38	159.0	COG1082@1|root,COG1082@2|Bacteria,4NI4H@976|Bacteroidetes,47MMY@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_642458_1	497964.CfE428DRAFT_0981	1.764e-106	359.0	COG2133@1|root,COG2133@2|Bacteria,46V3J@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Methane oxygenase PmoA	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
CMS2_k127_642458_0	861299.J421_5653	6.236e-148	483.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_642458_2	314230.DSM3645_14120	6.214e-77	266.0	COG1082@1|root,COG1082@2|Bacteria,2IXNX@203682|Planctomycetes	203682|Planctomycetes	G	COG1082 Sugar phosphate	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
CMS2_k127_642458_6	1286632.P278_08320	8.418e-10	67.0	COG1595@1|root,COG1595@2|Bacteria,4NF93@976|Bacteroidetes,1HX2Z@117743|Flavobacteriia	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_642458_3	1123242.JH636434_gene4731	4.368e-73	258.0	COG1131@1|root,COG1131@2|Bacteria,2IZVY@203682|Planctomycetes	203682|Planctomycetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_642458_5	344747.PM8797T_11661	3.211e-26	112.0	COG1725@1|root,COG1725@2|Bacteria,2J03Y@203682|Planctomycetes	203682|Planctomycetes	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS2_k127_6437937_3	1235796.C815_00378	4.022e-38	164.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes	1239|Firmicutes	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
CMS2_k127_6437937_0	517418.Ctha_1865	6.941e-70	260.0	COG5184@1|root,COG5492@1|root,COG5184@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,CHU_C,Calx-beta,ChW,Flg_new,Glug,Phage_TTP_12,RCC1
CMS2_k127_6437937_2	1121448.DGI_3172	1.991e-46	190.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43CFM@68525|delta/epsilon subdivisions,2X7QN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS2_k127_6437937_1	631362.Thi970DRAFT_03742	3.555e-60	216.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,1RRT6@1236|Gammaproteobacteria,1WXWX@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS2_k127_644257_3	1192034.CAP_3564	1.165e-47	173.0	COG2006@1|root,COG2006@2|Bacteria,1NSD4@1224|Proteobacteria,42YV4@68525|delta/epsilon subdivisions,2WTK6@28221|Deltaproteobacteria,2YWVS@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS2_k127_644257_1	1232410.KI421413_gene852	6.416e-60	209.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	pcaC	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
CMS2_k127_644257_2	530564.Psta_1884	4.111e-48	177.0	COG0542@1|root,COG0542@2|Bacteria,2IXHI@203682|Planctomycetes	203682|Planctomycetes	O	with chaperone activity ATP-binding	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
CMS2_k127_644257_7	1121948.AUAC01000006_gene548	1.948e-12	70.0	COG0457@1|root,COG0457@2|Bacteria,1R6ZR@1224|Proteobacteria,2TZEQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_644257_4	314230.DSM3645_26609	7.303e-40	157.0	COG2010@1|root,COG2133@1|root,COG3828@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,COG3828@2|Bacteria,2IYH1@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,Cytochrom_C,Cytochrome_CBB3,Laminin_G_3,ThuA
CMS2_k127_644257_5	373903.Hore_13810	7.932e-24	107.0	COG2250@1|root,COG2250@2|Bacteria,1VH7U@1239|Firmicutes,24TC7@186801|Clostridia	186801|Clostridia	S	PFAM HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_644257_0	886293.Sinac_6401	1.007e-84	295.0	COG0758@1|root,COG1948@1|root,COG0758@2|Bacteria,COG1948@2|Bacteria,2IX3D@203682|Planctomycetes	203682|Planctomycetes	L	TIGRFAM DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A,HHH_5
CMS2_k127_644257_9	1303518.CCALI_02493	2.493e-11	75.0	COG4969@1|root,COG4969@2|Bacteria	2|Bacteria	NU	cell adhesion	-	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,SBP_bac_10
CMS2_k127_644257_8	1124780.ANNU01000008_gene2683	2.045e-12	80.0	COG1649@1|root,COG3866@1|root,COG4733@1|root,COG1649@2|Bacteria,COG3866@2|Bacteria,COG4733@2|Bacteria,4P09P@976|Bacteroidetes,47MVU@768503|Cytophagia	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_644257_10	1492737.FEM08_26230	9.609e-07	62.0	COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,1I0G9@117743|Flavobacteriia,2NTFA@237|Flavobacterium	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6447485_4	661478.OP10G_0448	2.156e-08	67.0	COG2411@1|root,COG2411@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ASCH,PSCyt1,PSCyt2,PSD1
CMS2_k127_6447485_3	886293.Sinac_5667	1.07e-112	383.0	COG2133@1|root,COG2133@2|Bacteria,2IZH6@203682|Planctomycetes	203682|Planctomycetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS2_k127_6447485_1	1195236.CTER_0372	1.011e-193	614.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia	186801|Clostridia	G	family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
CMS2_k127_6447485_0	1123376.AUIU01000014_gene553	3.089e-272	861.0	COG1449@1|root,COG1449@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	DUF3536,Glyco_hydro_57
CMS2_k127_6447485_2	368407.Memar_1054	1.274e-171	554.0	COG1640@1|root,arCOG04681@2157|Archaea,2XTEN@28890|Euryarchaeota	28890|Euryarchaeota	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
CMS2_k127_6455748_12	1236542.BALM01000009_gene3026	0.0002281	47.0	COG0790@1|root,COG0790@2|Bacteria,1NFE8@1224|Proteobacteria,1SIM6@1236|Gammaproteobacteria,2Q8WB@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Sel1-like repeats.	-	-	-	-	-	-	-	-	-	-	-	-	Sel1
CMS2_k127_6455748_2	926556.Echvi_2317	3.229e-93	317.0	COG0469@1|root,COG0469@2|Bacteria,4NEEU@976|Bacteroidetes,47JS3@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
CMS2_k127_6455748_0	498761.HM1_0103	8.281e-124	408.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia	186801|Clostridia	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA2	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
CMS2_k127_6455748_11	1121271.AUCM01000011_gene1943	1.386e-05	53.0	2DMIM@1|root,32RUN@2|Bacteria,1MZ56@1224|Proteobacteria,2UHUH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6455748_5	429009.Adeg_2146	5.536e-57	213.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,42F5R@68295|Thermoanaerobacterales	186801|Clostridia	D	PFAM Cobyrinic acid a,c-diamide synthase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS2_k127_6455748_8	118168.MC7420_3203	3.039e-14	87.0	COG1511@1|root,COG1511@2|Bacteria,1G29D@1117|Cyanobacteria,1H90E@1150|Oscillatoriales	1117|Cyanobacteria	S	Tubulin like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,Tubulin_2,zinc_ribbon_2
CMS2_k127_6455748_4	426716.JOAJ01000002_gene2074	2.839e-65	234.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4FXF4@85025|Nocardiaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_6455748_10	1210884.HG799465_gene12130	5.591e-08	64.0	COG1277@1|root,COG1277@2|Bacteria,2J0S8@203682|Planctomycetes	203682|Planctomycetes	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
CMS2_k127_6455748_3	1122927.KB895420_gene4226	3.28e-85	290.0	COG3541@1|root,COG3541@2|Bacteria,1TT57@1239|Firmicutes,4HD38@91061|Bacilli,26RAT@186822|Paenibacillaceae	91061|Bacilli	S	Predicted nucleotidyltransferase	ycgL	-	-	ko:K07074	-	-	-	-	ko00000	-	-	-	Nuc-transf
CMS2_k127_6455748_9	671143.DAMO_0399	4.052e-13	74.0	COG1708@1|root,COG1708@2|Bacteria,2NS1D@2323|unclassified Bacteria	2|Bacteria	S	Nucleotidyltransferase domain	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
CMS2_k127_6455748_7	1499967.BAYZ01000076_gene790	5.8e-18	89.0	COG1895@1|root,COG1895@2|Bacteria	2|Bacteria	O	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_6455748_6	1396418.BATQ01000049_gene472	2.699e-42	159.0	COG0705@1|root,COG0705@2|Bacteria,46V9T@74201|Verrucomicrobia,2IWI7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS2_k127_6455748_1	658086.HMPREF0994_04365	5.051e-98	331.0	COG0644@1|root,COG0644@2|Bacteria,1TR0D@1239|Firmicutes,24BE3@186801|Clostridia,27S1C@186928|unclassified Lachnospiraceae	186801|Clostridia	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
CMS2_k127_6470067_4	1396141.BATP01000003_gene5009	1.754e-63	238.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Calx-beta,He_PIG,Laminin_G_3,PKD,PPC,RHS_repeat
CMS2_k127_6470067_3	1403819.BATR01000124_gene4422	3.594e-93	321.0	COG1520@1|root,COG1520@2|Bacteria,46U6I@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS2_k127_6470067_2	366602.Caul_1283	1.056e-104	350.0	COG2730@1|root,COG2730@2|Bacteria,1N2XP@1224|Proteobacteria,2TSHY@28211|Alphaproteobacteria,2KIB4@204458|Caulobacterales	204458|Caulobacterales	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase
CMS2_k127_6470067_0	521674.Plim_0111	9.886e-138	452.0	COG0673@1|root,COG0673@2|Bacteria,2IXJ0@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_6470067_1	177437.HRM2_20090	1.129e-112	374.0	COG3420@1|root,COG5434@1|root,COG3420@2|Bacteria,COG5434@2|Bacteria,1RJPM@1224|Proteobacteria,42T21@68525|delta/epsilon subdivisions,2WPCS@28221|Deltaproteobacteria,2MN82@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_6470067_5	391625.PPSIR1_33224	5.83e-06	57.0	28K2M@1|root,2Z9RY@2|Bacteria,1R6RC@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_647324_2	497964.CfE428DRAFT_2982	5.184e-54	198.0	COG1595@1|root,COG1595@2|Bacteria,46V3P@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
CMS2_k127_647324_1	251221.35213287	1.238e-62	230.0	COG3594@1|root,COG3594@2|Bacteria	2|Bacteria	G	nodulation	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
CMS2_k127_647324_0	1396141.BATP01000019_gene1735	3.641e-144	486.0	COG0515@1|root,COG1714@1|root,COG0515@2|Bacteria,COG1714@2|Bacteria,46XFS@74201|Verrucomicrobia,2IVSV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS2_k127_6483550_1	402880.MmarC5_1266	7.619e-45	190.0	arCOG02636@1|root,arCOG02636@2157|Archaea	2157|Archaea	-	-	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Eco57I,MTS,N6_Mtase,TaqI_C
CMS2_k127_6483550_2	756883.Halar_3419	3.732e-36	153.0	COG0151@1|root,arCOG04415@2157|Archaea	2157|Archaea	F	Belongs to the GARS family	-	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C
CMS2_k127_6483550_3	1235797.C816_00616	4.797e-07	61.0	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,247V6@186801|Clostridia,2N69M@216572|Oscillospiraceae	186801|Clostridia	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
CMS2_k127_6483550_0	411461.DORFOR_00020	9.31e-61	227.0	28KIJ@1|root,2ZA3S@2|Bacteria,1TSCG@1239|Firmicutes,24DNK@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6490942_1	69395.JQLZ01000001_gene3066	4.328e-48	176.0	COG3534@1|root,COG3534@2|Bacteria,1PPWJ@1224|Proteobacteria,2TWSD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
CMS2_k127_650098_6	344747.PM8797T_11661	2.686e-25	109.0	COG1725@1|root,COG1725@2|Bacteria,2J03Y@203682|Planctomycetes	203682|Planctomycetes	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS2_k127_650098_10	714943.Mucpa_7131	4.131e-10	65.0	COG3695@1|root,COG3695@2|Bacteria,4NZHS@976|Bacteroidetes,1IZ68@117747|Sphingobacteriia	976|Bacteroidetes	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
CMS2_k127_650098_8	714943.Mucpa_7131	1.074e-19	91.0	COG3695@1|root,COG3695@2|Bacteria,4NZHS@976|Bacteroidetes,1IZ68@117747|Sphingobacteriia	976|Bacteroidetes	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
CMS2_k127_650098_2	383372.Rcas_0427	9.62e-82	279.0	COG0454@1|root,COG0456@2|Bacteria,2GBQI@200795|Chloroflexi,3762F@32061|Chloroflexia	32061|Chloroflexia	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	FR47
CMS2_k127_650098_1	1122605.KB893645_gene1148	4.537e-167	541.0	COG3119@1|root,COG3119@2|Bacteria,4NF1X@976|Bacteroidetes,1IS5G@117747|Sphingobacteriia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_650098_4	697281.Mahau_0616	1.339e-68	252.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,42F58@68295|Thermoanaerobacterales	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
CMS2_k127_650098_7	1210884.HG799465_gene12149	1.229e-20	106.0	2EPQ7@1|root,33HAS@2|Bacteria,2J1P9@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_650098_3	909663.KI867150_gene1321	6.748e-71	252.0	COG0500@1|root,COG1846@1|root,COG1846@2|Bacteria,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,43BRY@68525|delta/epsilon subdivisions,2X72R@28221|Deltaproteobacteria,2MQCD@213462|Syntrophobacterales	28221|Deltaproteobacteria	KQ	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
CMS2_k127_650098_0	1041930.Mtc_0756	1.184e-233	744.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,2NAJJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
CMS2_k127_650098_5	526225.Gobs_2651	4.128e-28	120.0	COG3963@1|root,COG3963@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,RrnaAD
CMS2_k127_650098_9	105559.Nwat_2850	1.925e-13	79.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,1RQSM@1236|Gammaproteobacteria,1WYMP@135613|Chromatiales	135613|Chromatiales	M	polysaccharide export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
CMS2_k127_6508045_0	926561.KB900617_gene1821	1.716e-153	506.0	COG1032@1|root,COG1032@2|Bacteria,1TR2C@1239|Firmicutes,248HM@186801|Clostridia,3WA9H@53433|Halanaerobiales	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS2_k127_6508045_2	398767.Glov_3572	6.733e-45	167.0	COG1487@1|root,COG1487@2|Bacteria,1N44Q@1224|Proteobacteria,42UNG@68525|delta/epsilon subdivisions,2WRVS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS2_k127_6508045_1	247490.KSU1_D0876	2.402e-59	218.0	COG1477@1|root,COG3901@1|root,COG1477@2|Bacteria,COG3901@2|Bacteria,2IYYX@203682|Planctomycetes	203682|Planctomycetes	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE,FMN_bind
CMS2_k127_6508045_4	237368.SCABRO_02026	4.497e-18	89.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	ko:K07339	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HicA_toxin
CMS2_k127_6508045_3	472759.Nhal_1261	2.656e-20	93.0	COG1598@1|root,COG1598@2|Bacteria,1NNW6@1224|Proteobacteria,1STP0@1236|Gammaproteobacteria,1X1YA@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6508045_5	177439.DP0744	5.648e-16	79.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3394)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
CMS2_k127_6513806_0	1121904.ARBP01000004_gene988	1.051e-212	671.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,47MV2@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
CMS2_k127_6513806_2	869213.JCM21142_72806	3.418e-166	542.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_35,Cellulase
CMS2_k127_6513806_3	1122925.KB895384_gene3265	2.857e-135	442.0	COG2942@1|root,COG2942@2|Bacteria,1TQMG@1239|Firmicutes,4HE7U@91061|Bacilli,26T2B@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man)	rnbP	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
CMS2_k127_6513806_1	935845.JADQ01000050_gene3903	8.067e-197	623.0	COG2152@1|root,COG2152@2|Bacteria,1TNYI@1239|Firmicutes,4HA02@91061|Bacilli,26QPI@186822|Paenibacillaceae	91061|Bacilli	G	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose	unk1	-	2.4.1.281	ko:K16212	-	-	R09943	RC00049	ko00000,ko01000	-	-	-	Glyco_hydro_130
CMS2_k127_6513806_4	1380394.JADL01000011_gene3996	1.23e-28	120.0	COG1051@1|root,COG1051@2|Bacteria,1PHFR@1224|Proteobacteria,2VCE5@28211|Alphaproteobacteria,2JXK9@204441|Rhodospirillales	204441|Rhodospirillales	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS2_k127_653565_3	690850.Desaf_2584	2.692e-42	160.0	COG0385@1|root,COG0385@2|Bacteria,1Q36S@1224|Proteobacteria,42WV7@68525|delta/epsilon subdivisions,2WSXX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Bile acid sodium symporter	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
CMS2_k127_653565_1	118173.KB235914_gene2645	2.053e-233	728.0	COG5361@1|root,COG5361@2|Bacteria,1G49Q@1117|Cyanobacteria,1H9SH@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
CMS2_k127_653565_0	512565.AMIS_44900	0.0	1224.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4D8NI@85008|Micromonosporales	201174|Actinobacteria	P	Sulfatase	atsB	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF1269,Sulfatase
CMS2_k127_653565_2	1249627.D779_4053	4.864e-59	205.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1X0RX@135613|Chromatiales	135613|Chromatiales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6539599_3	1123226.KB899294_gene539	1.176e-46	175.0	COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,4H9NN@91061|Bacilli,26RR1@186822|Paenibacillaceae	91061|Bacilli	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
CMS2_k127_6539599_4	1499967.BAYZ01000066_gene6052	2.097e-18	88.0	COG2250@1|root,COG2250@2|Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_6539599_1	756272.Plabr_2883	2.687e-52	202.0	COG0515@1|root,COG0515@2|Bacteria,2J2D5@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_6539599_2	485913.Krac_9547	2.951e-47	179.0	COG0631@1|root,COG0631@2|Bacteria,2G8RD@200795|Chloroflexi	200795|Chloroflexi	T	SMART protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
CMS2_k127_6539599_0	237368.SCABRO_00373	5.553e-74	258.0	COG3481@1|root,COG3481@2|Bacteria,2IX5B@203682|Planctomycetes	203682|Planctomycetes	S	Nucleic acid binding	-	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
CMS2_k127_6539661_15	521045.Kole_1769	4.585e-13	70.0	COG2610@1|root,COG2610@2|Bacteria,2GCMX@200918|Thermotogae	200918|Thermotogae	EG	PFAM Gluconate transporter	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
CMS2_k127_6539661_14	1219084.AP014508_gene1579	5.457e-40	163.0	COG2872@1|root,COG2872@2|Bacteria,2GCF0@200918|Thermotogae	200918|Thermotogae	S	Threonyl alanyl tRNA synthetase SAD	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA_SAD
CMS2_k127_6539661_13	160799.PBOR_16510	1.672e-44	167.0	292S5@1|root,2ZQ9V@2|Bacteria,1V53B@1239|Firmicutes	1239|Firmicutes	S	Putative zincin peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3267
CMS2_k127_6539661_5	240016.ABIZ01000001_gene764	1.364e-138	456.0	COG3119@1|root,COG3119@2|Bacteria,46ZJS@74201|Verrucomicrobia,2IVBK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_6539661_12	497964.CfE428DRAFT_2312	2.388e-52	203.0	COG1082@1|root,COG1082@2|Bacteria,46UG0@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_6539661_6	1499967.BAYZ01000147_gene684	2.522e-133	432.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
CMS2_k127_6539661_4	1499967.BAYZ01000171_gene5541	1.086e-147	471.0	COG2084@1|root,COG2084@2|Bacteria,2NQRW@2323|unclassified Bacteria	2|Bacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	garR	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	iNRG857_1313.NRG857_15520	NAD_binding_11,NAD_binding_2
CMS2_k127_6539661_7	518766.Rmar_0474	1.381e-120	399.0	COG2017@1|root,COG2017@2|Bacteria,4NF5G@976|Bacteroidetes	976|Bacteroidetes	G	Converts alpha-aldose to the beta-anomer	galM	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
CMS2_k127_6539661_3	243090.RB9828	9.618e-148	486.0	COG1914@1|root,COG1914@2|Bacteria,2IWTS@203682|Planctomycetes	203682|Planctomycetes	P	COG1914 Mn2 and Fe2 transporters of the NRAMP family	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
CMS2_k127_6539661_1	1499967.BAYZ01000147_gene687	5.373e-171	553.0	2EDIX@1|root,337ET@2|Bacteria	2|Bacteria	S	tagaturonate epimerase	-	-	-	-	-	-	-	-	-	-	-	-	UxaE
CMS2_k127_6539661_10	1499967.BAYZ01000147_gene691	9.332e-102	339.0	COG1028@1|root,COG1028@2|Bacteria,2NP35@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS2_k127_6539661_0	1499967.BAYZ01000151_gene1677	1.827e-176	562.0	COG1454@1|root,COG1454@2|Bacteria,2NQ5W@2323|unclassified Bacteria	2|Bacteria	C	Iron-containing alcohol dehydrogenase	kdnB	GO:0003674,GO:0003824,GO:0004022,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.1.1,1.1.3.48	ko:K13954,ko:K19714	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R04880,R05233,R05234,R06917,R06927,R11394	RC00050,RC00088,RC00099,RC00116,RC00649,RC03427	ko00000,ko00001,ko01000,ko01005	-	-	-	CTP_transf_3,Fe-ADH
CMS2_k127_6539661_8	401526.TcarDRAFT_0648	4.328e-112	378.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,4H28D@909932|Negativicutes	909932|Negativicutes	S	Domain of unknown function (DUF2088)	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
CMS2_k127_6539661_9	338963.Pcar_1226	9.659e-109	366.0	COG1929@1|root,COG1929@2|Bacteria,1MVG9@1224|Proteobacteria,42MRF@68525|delta/epsilon subdivisions,2WNGJ@28221|Deltaproteobacteria,43UUK@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
CMS2_k127_6539661_2	234267.Acid_7008	1.747e-159	515.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_6539661_11	1123278.KB893596_gene2660	2.213e-81	284.0	COG1082@1|root,COG1082@2|Bacteria,4NIDT@976|Bacteroidetes,47JR4@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_6539661_16	927658.AJUM01000007_gene2722	5.064e-10	64.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9
CMS2_k127_6551004_13	1380390.JIAT01000011_gene2883	3.419e-12	75.0	COG0028@1|root,COG0515@1|root,COG1409@1|root,COG1749@1|root,COG2374@1|root,COG3291@1|root,COG3509@1|root,COG4733@1|root,COG0028@2|Bacteria,COG0515@2|Bacteria,COG1409@2|Bacteria,COG1749@2|Bacteria,COG2374@2|Bacteria,COG3291@2|Bacteria,COG3509@2|Bacteria,COG4733@2|Bacteria,2I2X3@201174|Actinobacteria,4CSIX@84995|Rubrobacteria	84995|Rubrobacteria	N	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,fn3
CMS2_k127_6551004_12	1303518.CCALI_02394	4.368e-17	91.0	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_6551004_1	861299.J421_5653	1.016e-135	448.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_6551004_5	1123278.KB893596_gene2660	5.381e-80	279.0	COG1082@1|root,COG1082@2|Bacteria,4NIDT@976|Bacteroidetes,47JR4@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_6551004_8	1123008.KB905699_gene1962	1.246e-38	166.0	COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,2FMQ9@200643|Bacteroidia,22W3K@171551|Porphyromonadaceae	976|Bacteroidetes	G	Glycosyl hydrolase family 92	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_92
CMS2_k127_6551004_7	278963.ATWD01000001_gene2879	6.198e-61	238.0	COG0383@1|root,COG0383@2|Bacteria,3Y3ID@57723|Acidobacteria,2JINT@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolase 38 domain protein	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
CMS2_k127_6551004_2	1195236.CTER_4883	5.152e-122	411.0	COG2006@1|root,COG2006@2|Bacteria,1VRZ8@1239|Firmicutes,24Z9V@186801|Clostridia,3WN5G@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Dockerin_1
CMS2_k127_6551004_3	1122925.KB895391_gene1548	5.3e-105	353.0	COG1312@1|root,COG1312@2|Bacteria,1TP5F@1239|Firmicutes,4H9UR@91061|Bacilli,26TTG@186822|Paenibacillaceae	91061|Bacilli	G	D-mannonate dehydratase (UxuA)	-	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
CMS2_k127_6551004_11	794903.OPIT5_07225	1.83e-21	97.0	COG2730@1|root,COG2730@2|Bacteria,46XJ7@74201|Verrucomicrobia,3K99G@414999|Opitutae	414999|Opitutae	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase
CMS2_k127_6551004_14	426117.M446_1511	7.635e-12	68.0	COG2730@1|root,COG2730@2|Bacteria,1R4XH@1224|Proteobacteria,2U3A9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
CMS2_k127_6551004_4	1121405.dsmv_0279	1.79e-88	299.0	2BM5T@1|root,32FPE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6551004_16	889378.Spiaf_1334	2.063e-08	64.0	2EFJZ@1|root,339C8@2|Bacteria,2J6Y9@203691|Spirochaetes	203691|Spirochaetes	S	Predicted periplasmic protein (DUF2271)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2271
CMS2_k127_6551004_6	326297.Sama_1194	9.313e-64	229.0	COG0673@1|root,COG0673@2|Bacteria,1PE56@1224|Proteobacteria,1RWPI@1236|Gammaproteobacteria,2QBFA@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Glycosyl hydrolase family 109 protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,TAT_signal
CMS2_k127_6551004_9	861299.J421_2200	5.111e-37	145.0	COG0673@1|root,COG0673@2|Bacteria,1ZSRB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_6551004_0	1051632.TPY_1184	0.0	1041.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,3WCC2@538999|Clostridiales incertae sedis	186801|Clostridia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
CMS2_k127_6551004_15	1499967.BAYZ01000176_gene5666	5.622e-11	67.0	COG1708@1|root,COG1708@2|Bacteria,2NRZ7@2323|unclassified Bacteria	2|Bacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CMS2_k127_6551004_10	1499967.BAYZ01000076_gene790	2.778e-24	106.0	COG1895@1|root,COG1895@2|Bacteria	2|Bacteria	O	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_6552822_5	1183438.GKIL_4354	1.884e-45	179.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS2_k127_6552822_3	1267535.KB906767_gene632	6.342e-108	355.0	COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria,2JIKD@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_6552822_7	575540.Isop_1921	8.776e-33	132.0	COG0399@1|root,COG0399@2|Bacteria,2J55P@203682|Planctomycetes	203682|Planctomycetes	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
CMS2_k127_6552822_4	401053.AciPR4_2545	2.633e-104	353.0	COG0845@1|root,COG0845@2|Bacteria,3Y2FV@57723|Acidobacteria,2JHN2@204432|Acidobacteriia	204432|Acidobacteriia	M	MFP subunit	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
CMS2_k127_6552822_1	861299.J421_0949	7.592e-160	533.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_0949|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6552822_6	1521187.JPIM01000076_gene1203	6.446e-43	160.0	COG2250@1|root,COG2250@2|Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS2_k127_6552822_8	933262.AXAM01000092_gene2932	2.962e-08	61.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CMS2_k127_6552822_2	234267.Acid_4169	9.471e-143	466.0	COG5000@1|root,COG5000@2|Bacteria,3Y2TD@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
CMS2_k127_6552822_0	234267.Acid_4168	4.878e-182	580.0	COG2204@1|root,COG2204@2|Bacteria,3Y33M@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS2_k127_656210_2	247490.KSU1_B0164	7.637e-137	448.0	COG0766@1|root,COG0766@2|Bacteria,2IWRI@203682|Planctomycetes	203682|Planctomycetes	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
CMS2_k127_656210_6	565045.NOR51B_2871	1.5e-09	68.0	COG2982@1|root,COG2982@2|Bacteria,1N0N6@1224|Proteobacteria,1S8WD@1236|Gammaproteobacteria,1JBSM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_656210_5	583355.Caka_0968	1.664e-12	72.0	COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,46UC1@74201|Verrucomicrobia,3K9FB@414999|Opitutae	414999|Opitutae	C	TIGRFAM 40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_656210_4	1303518.CCALI_02394	1.143e-20	101.0	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_656210_3	1227352.C173_16536	2.212e-51	200.0	COG0644@1|root,COG0644@2|Bacteria,1TR0D@1239|Firmicutes,4HBWH@91061|Bacilli,26SAR@186822|Paenibacillaceae	91061|Bacilli	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
CMS2_k127_656210_1	1123277.KB893206_gene3445	2.157e-236	752.0	COG3525@1|root,COG3525@2|Bacteria,4NH5U@976|Bacteroidetes	976|Bacteroidetes	G	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_20b
CMS2_k127_656210_0	1123277.KB893176_gene3707	1.149e-249	799.0	COG2173@1|root,COG2173@2|Bacteria	2|Bacteria	M	zinc D-Ala-D-Ala carboxypeptidase activity	-	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15,SH3_3,SH3_4,VanY
CMS2_k127_6562548_5	1123401.JHYQ01000009_gene2295	9.674e-25	106.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,1RRXR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ATPase, AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS2_k127_6562548_3	273068.TTE0370	2.202e-34	138.0	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia,42FTB@68295|Thermoanaerobacterales	186801|Clostridia	H	ATP corrinoid adenosyltransferase BtuR CobO CobP	cobO	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
CMS2_k127_6562548_2	1123508.JH636440_gene2177	1.092e-53	197.0	COG1211@1|root,COG1211@2|Bacteria,2IYXJ@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
CMS2_k127_6562548_0	1123054.KB907719_gene2738	5.054e-102	351.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1X0KT@135613|Chromatiales	135613|Chromatiales	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
CMS2_k127_6562548_1	1095749.HMPREF1052_0097	1.069e-56	205.0	COG0512@1|root,COG0512@2|Bacteria,1RAKJ@1224|Proteobacteria,1RREB@1236|Gammaproteobacteria,1Y7E2@135625|Pasteurellales	135625|Pasteurellales	EH	Anthranilate synthase	trpG	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
CMS2_k127_6562548_4	1121396.KB893079_gene794	8.72e-33	130.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,42NRG@68525|delta/epsilon subdivisions,2WJRU@28221|Deltaproteobacteria,2MIMY@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2495	GATase,Glycos_trans_3N,Glycos_transf_3
CMS2_k127_6562856_0	471854.Dfer_1582	4.332e-89	300.0	COG2866@1|root,COG2866@2|Bacteria,4NJB9@976|Bacteroidetes,47SV8@768503|Cytophagia	976|Bacteroidetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS2_k127_6562856_2	886293.Sinac_0273	3.437e-13	81.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_6562856_1	452637.Oter_1853	7.506e-41	167.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_6581463_4	240016.ABIZ01000001_gene1588	9.252e-62	222.0	COG0673@1|root,COG0673@2|Bacteria,46TM9@74201|Verrucomicrobia,2ITZ3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_6581463_3	608538.HTH_0202	4.632e-65	246.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,2G3NC@200783|Aquificae	200783|Aquificae	I	PFAM AMP-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
CMS2_k127_6581463_8	1303518.CCALI_01870	9.878e-24	112.0	COG1341@1|root,COG1341@2|Bacteria	2|Bacteria	S	polynucleotide 5'-hydroxyl-kinase activity	-	-	-	ko:K06947	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	CLP1_P
CMS2_k127_6581463_5	195250.CM001776_gene2432	3.738e-45	175.0	COG4923@1|root,COG4923@2|Bacteria	2|Bacteria	K	Protein of unknown function (DUF429)	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF429
CMS2_k127_6581463_7	1283300.ATXB01000001_gene819	2.171e-34	140.0	COG1618@1|root,COG1618@2|Bacteria,1N4XQ@1224|Proteobacteria	1224|Proteobacteria	F	NTPase	-	-	-	-	-	-	-	-	-	-	-	-	NTPase_1
CMS2_k127_6581463_10	192952.MM_2938	1.137e-16	94.0	COG3291@1|root,COG5563@1|root,arCOG03501@2157|Archaea,arCOG03504@2157|Archaea	2157|Archaea	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Disaggr_assoc
CMS2_k127_6581463_12	1284775.HMPREF1640_07925	1.197e-08	68.0	2DB82@1|root,2Z7PX@2|Bacteria,4NEW5@976|Bacteroidetes,2FMDV@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_6581463_2	1304885.AUEY01000005_gene892	1.72e-82	284.0	COG0598@1|root,COG0598@2|Bacteria,1RGGI@1224|Proteobacteria,42UX4@68525|delta/epsilon subdivisions,2WQYH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Mg2 transporter protein CorA family protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
CMS2_k127_6581463_1	1142394.PSMK_22190	4.698e-115	383.0	COG0399@1|root,COG0399@2|Bacteria,2IZ4J@203682|Planctomycetes	203682|Planctomycetes	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS2_k127_6581463_0	243090.RB1828	5.387e-234	739.0	COG3540@1|root,COG3540@2|Bacteria,2J1R1@203682|Planctomycetes	203682|Planctomycetes	P	Alkaline phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6581463_11	1396141.BATP01000056_gene3251	1.466e-14	81.0	COG1595@1|root,COG1595@2|Bacteria,46VNT@74201|Verrucomicrobia,2IVV9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4
CMS2_k127_6581463_6	1444711.CCJF01000005_gene918	4.884e-35	145.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
CMS2_k127_6581463_9	285535.JOEY01000024_gene320	3.565e-19	94.0	COG0637@1|root,COG0637@2|Bacteria,2GNX0@201174|Actinobacteria	201174|Actinobacteria	V	TIGRFAM HAD-superfamily hydrolase subfamily IA, variant 3	yfbT	-	3.1.3.23	ko:K19270	-	-	-	-	ko00000,ko01000	-	-	-	HAD_2
CMS2_k127_6599182_4	374847.Kcr_0385	0.0001943	54.0	COG1470@1|root,arCOG03511@1|root,arCOG07813@1|root,arCOG02087@2157|Archaea,arCOG03511@2157|Archaea,arCOG07813@2157|Archaea	2157|Archaea	C	LamG domain protein jellyroll fold domain protein	-	-	2.4.99.18,3.5.1.56	ko:K03418,ko:K07151	ko00510,ko00513,ko00630,ko01100,ko04141,map00510,map00513,map00630,map01100,map04141	M00072	R02509,R04216,R05976	RC00005,RC00111,RC00482,RC00731	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	CarboxypepD_reg,DUF2341,Laminin_G_3,PKD,Pilin_N,STT3
CMS2_k127_6599182_2	1280380.KR100_07485	7.992e-11	75.0	COG0265@1|root,COG1262@1|root,COG4412@1|root,COG0265@2|Bacteria,COG1262@2|Bacteria,COG4412@2|Bacteria,1GHF4@1117|Cyanobacteria,1GZ5H@1129|Synechococcus	1117|Cyanobacteria	Q	Tryptophan-rich Synechocystis species C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,W_rich_C
CMS2_k127_6599182_0	643867.Ftrac_2180	1.267e-15	84.0	COG1595@1|root,COG1595@2|Bacteria,4NF93@976|Bacteroidetes,47KW3@768503|Cytophagia	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_6599182_1	1262449.CP6013_0770	2.736e-13	83.0	COG0457@1|root,COG3266@1|root,COG4676@1|root,COG4870@1|root,COG0457@2|Bacteria,COG3266@2|Bacteria,COG4676@2|Bacteria,COG4870@2|Bacteria,1VDA3@1239|Firmicutes	1239|Firmicutes	O	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Flg_new,TPR_19
CMS2_k127_6599182_3	192952.MM_1144	1.956e-09	71.0	COG5563@1|root,arCOG03499@1|root,arCOG03499@2157|Archaea,arCOG03501@2157|Archaea	2157|Archaea	S	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Disaggr_assoc,Disaggr_repeat,PKD
CMS2_k127_6609003_4	886293.Sinac_3827	1.557e-12	83.0	COG1595@1|root,COG1595@2|Bacteria,2J3QA@203682|Planctomycetes	2|Bacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_6609003_2	344747.PM8797T_13248	3.576e-62	247.0	COG4219@1|root,COG4932@1|root,COG4219@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	DUF3738,Peptidase_M56
CMS2_k127_6609003_3	344747.PM8797T_13243	1.983e-32	131.0	COG3682@1|root,COG3682@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS2_k127_6609003_0	706587.Desti_3797	2.281e-176	559.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42N83@68525|delta/epsilon subdivisions,2WJFF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
CMS2_k127_6609003_1	1379698.RBG1_1C00001G0623	4.163e-74	251.0	COG1131@1|root,COG1131@2|Bacteria,2NP0I@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	ybhF	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_6629342_6	1035197.HMPREF9999_00185	7.914e-44	165.0	COG0701@1|root,COG2608@1|root,COG0701@2|Bacteria,COG2608@2|Bacteria,4NDUJ@976|Bacteroidetes,2FNF8@200643|Bacteroidia	976|Bacteroidetes	P	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1,HMA
CMS2_k127_6629342_3	1232410.KI421413_gene766	4.223e-79	279.0	COG1145@1|root,COG1145@2|Bacteria,1PW12@1224|Proteobacteria,42MZ9@68525|delta/epsilon subdivisions,2WN0W@28221|Deltaproteobacteria,43SWA@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
CMS2_k127_6629342_0	891968.Anamo_1760	2.125e-239	752.0	COG0369@1|root,COG1151@2|Bacteria,3TA79@508458|Synergistetes	508458|Synergistetes	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
CMS2_k127_6629342_4	644282.Deba_3000	2.889e-51	186.0	COG1418@1|root,COG1418@2|Bacteria,1R60M@1224|Proteobacteria,42NFJ@68525|delta/epsilon subdivisions,2WIJT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM metal-dependent phosphohydrolase HD sub	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS2_k127_6629342_10	1125863.JAFN01000001_gene1836	5.515e-33	134.0	COG1917@1|root,COG1917@2|Bacteria,1RJX2@1224|Proteobacteria,42TVK@68525|delta/epsilon subdivisions,2WQ2T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS2_k127_6629342_9	1047013.AQSP01000144_gene912	5.464e-36	141.0	COG1959@1|root,COG1959@2|Bacteria,2NQ8B@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulator, BadM Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS2_k127_6629342_7	879212.DespoDRAFT_01673	3.716e-40	151.0	COG0614@1|root,COG0614@2|Bacteria,1N7EM@1224|Proteobacteria,42VJU@68525|delta/epsilon subdivisions,2WRA4@28221|Deltaproteobacteria,2MP0R@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
CMS2_k127_6629342_2	945713.IALB_0861	7.691e-154	505.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	nrfA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0098809,GO:1901363	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z5669	Cytochrom_C552
CMS2_k127_6629342_5	1189612.A33Q_3612	2.187e-47	178.0	COG3005@1|root,COG3005@2|Bacteria,4NK7R@976|Bacteroidetes,47M7M@768503|Cytophagia	976|Bacteroidetes	C	PFAM NapC NirT cytochrome c family, N-terminal region	nrfH	-	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT
CMS2_k127_6629342_8	497964.CfE428DRAFT_2475	2.162e-38	160.0	COG3577@1|root,COG3577@2|Bacteria	2|Bacteria	S	aspartic-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
CMS2_k127_6629342_11	1242864.D187_001317	2.547e-21	106.0	COG1404@1|root,COG4124@1|root,COG1404@2|Bacteria,COG4124@2|Bacteria,1Q17Q@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the glycosyl hydrolase 26 family	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Glyco_hydro_26
CMS2_k127_6629342_1	1210884.HG799464_gene10777	3.291e-195	620.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH,Hydrolase_4,Peptidase_S15,Peptidase_S9
CMS2_k127_6636191_2	344747.PM8797T_13048	3.171e-70	242.0	COG3119@1|root,COG3119@2|Bacteria,2IX0S@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS2_k127_6636191_3	706587.Desti_2318	3.571e-55	201.0	COG1595@1|root,COG1595@2|Bacteria,1N413@1224|Proteobacteria,42SGS@68525|delta/epsilon subdivisions,2WPQ9@28221|Deltaproteobacteria,2MQN3@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_6636191_5	706587.Desti_2320	1.009e-05	55.0	2CGJ8@1|root,2ZF4E@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6636191_1	794903.OPIT5_04755	7.381e-110	364.0	COG2152@1|root,COG2152@2|Bacteria,46YKJ@74201|Verrucomicrobia,3K8SE@414999|Opitutae	2|Bacteria	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	2.4.1.339,2.4.1.340	ko:K20885	-	-	R11397,R11398	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
CMS2_k127_6636191_0	497964.CfE428DRAFT_6049	4.988e-148	482.0	COG0673@1|root,COG0673@2|Bacteria,46U0A@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_6636191_4	344747.PM8797T_09879	5.755e-41	163.0	COG1914@1|root,COG1914@2|Bacteria,2IZ88@203682|Planctomycetes	203682|Planctomycetes	P	Cytochrome ba3-putative manganese transport protein mntH	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
CMS2_k127_6659559_0	1267535.KB906767_gene2913	4.027e-123	402.0	COG4974@1|root,COG4974@2|Bacteria,3Y73V@57723|Acidobacteria	57723|Acidobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
CMS2_k127_6659559_1	1123242.JH636434_gene4078	1.281e-111	371.0	COG0500@1|root,COG2226@2|Bacteria,2IXEP@203682|Planctomycetes	203682|Planctomycetes	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
CMS2_k127_6667595_18	1206732.BAGD01000081_gene3364	3.383e-12	78.0	COG1397@1|root,COG1397@2|Bacteria,2HSBE@201174|Actinobacteria,4FZPT@85025|Nocardiaceae	201174|Actinobacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6667595_14	1142394.PSMK_15550	4.436e-25	111.0	COG2839@1|root,COG2839@2|Bacteria,2J1KN@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF456)	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
CMS2_k127_6667595_21	1379698.RBG1_1C00001G0507	0.0004016	49.0	2C4GJ@1|root,2ZD2G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6667595_8	472759.Nhal_1965	1.917e-65	231.0	COG0671@1|root,COG0671@2|Bacteria,1NAJ7@1224|Proteobacteria,1SDY6@1236|Gammaproteobacteria,1WW8C@135613|Chromatiales	135613|Chromatiales	I	PFAM phosphoesterase PA-phosphatase related	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
CMS2_k127_6667595_7	1185876.BN8_00852	1.949e-82	297.0	COG0793@1|root,COG0793@2|Bacteria,4NEFX@976|Bacteroidetes,47S2P@768503|Cytophagia	976|Bacteroidetes	M	Peptidase, S41 family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S41,Tricorn_C1
CMS2_k127_6667595_19	1007104.SUS17_1537	4.484e-12	74.0	COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2U6J3@28211|Alphaproteobacteria,2K57J@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_6667595_0	1131462.DCF50_p1172	6.767e-178	574.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia,2612Q@186807|Peptococcaceae	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS2_k127_6667595_10	593117.TGAM_0176	6.891e-53	194.0	COG0274@1|root,arCOG04320@2157|Archaea,2XT2D@28890|Euryarchaeota,242NJ@183968|Thermococci	183968|Thermococci	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
CMS2_k127_6667595_4	1089553.Tph_c20550	2.311e-99	341.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,42FM5@68295|Thermoanaerobacterales	186801|Clostridia	EH	Anthranilate synthase component I, N terminal region	pabB	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind,GATase
CMS2_k127_6667595_11	515635.Dtur_1364	1.13e-52	197.0	COG0115@1|root,COG0115@2|Bacteria	2|Bacteria	E	branched-chain-amino-acid transaminase activity	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CMS2_k127_6667595_5	448385.sce4374	4.041e-94	321.0	COG0327@1|root,COG0327@2|Bacteria,1R34P@1224|Proteobacteria,42P4V@68525|delta/epsilon subdivisions,2X6FS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	yqfO	-	-	-	-	-	-	-	-	-	-	-	NIF3
CMS2_k127_6667595_12	237368.SCABRO_00204	4.643e-46	177.0	COG1386@1|root,COG1386@2|Bacteria,2IZNB@203682|Planctomycetes	203682|Planctomycetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
CMS2_k127_6667595_2	1121904.ARBP01000008_gene3424	4.081e-131	430.0	COG1506@1|root,COG1506@2|Bacteria,4PNN5@976|Bacteroidetes,47YBM@768503|Cytophagia	976|Bacteroidetes	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
CMS2_k127_6667595_1	760192.Halhy_3573	9.608e-171	555.0	COG4225@1|root,COG4225@2|Bacteria,4NF1N@976|Bacteroidetes,1IP96@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Heparinase II III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4962,Hepar_II_III
CMS2_k127_6667595_6	756272.Plabr_3368	1.25e-92	310.0	COG0363@1|root,COG0363@2|Bacteria,2IYJ5@203682|Planctomycetes	203682|Planctomycetes	G	6-phosphogluconolactonase glucosamine-6-phosphate isomerase deaminase	-	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso
CMS2_k127_6667595_13	517418.Ctha_1865	7.487e-46	180.0	COG5184@1|root,COG5492@1|root,COG5184@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,CHU_C,Calx-beta,ChW,Flg_new,Glug,Phage_TTP_12,RCC1
CMS2_k127_6667595_15	335543.Sfum_2876	3.199e-15	90.0	COG3420@1|root,COG3420@2|Bacteria,1R94C@1224|Proteobacteria	1224|Proteobacteria	P	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_6667595_20	1121104.AQXH01000001_gene1672	1.349e-05	52.0	COG1404@1|root,COG2931@1|root,COG3291@1|root,COG3391@1|root,COG4932@1|root,COG5492@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,COG5492@2|Bacteria,4P2UU@976|Bacteroidetes,1IXKE@117747|Sphingobacteriia	976|Bacteroidetes	MNOQ	Cadherin domain	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cadherin,DUF285,TIG,TSP_3
CMS2_k127_6667595_3	886293.Sinac_5476	4.745e-104	358.0	COG0153@1|root,COG1207@1|root,COG0153@2|Bacteria,COG1207@2|Bacteria	2|Bacteria	M	glucosamine-1-phosphate N-acetyltransferase activity	galK	-	2.3.1.209,2.7.1.157,2.7.1.6	ko:K00849,ko:K02406,ko:K18674,ko:K21379	ko00052,ko00520,ko01100,ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map00052,map00520,map01100,map02020,map02040,map04621,map04626,map05132,map05134	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko02035,ko04147	-	-	-	DUF4954,GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg,Hexapep
CMS2_k127_6667595_9	525904.Tter_2697	1.925e-54	200.0	COG1820@1|root,COG1820@2|Bacteria,2NQKP@2323|unclassified Bacteria	2|Bacteria	G	Amidohydrolase family	nagA	-	3.5.1.25,3.5.99.6	ko:K01443,ko:K02564	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R00765,R02059	RC00163,RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
CMS2_k127_669685_1	756272.Plabr_2744	1.046e-73	249.0	COG3119@1|root,COG3119@2|Bacteria,2IYNZ@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_669685_3	344747.PM8797T_29093	1.05e-37	145.0	COG3119@1|root,COG3119@2|Bacteria,2IYNZ@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_669685_4	1069533.Sinf_1978	1.91e-23	105.0	COG3877@1|root,COG3877@2|Bacteria,1VGSH@1239|Firmicutes,4HQ68@91061|Bacilli	91061|Bacilli	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
CMS2_k127_669685_0	383372.Rcas_1653	2.172e-77	288.0	COG2366@1|root,COG2366@2|Bacteria,2G63N@200795|Chloroflexi,376RD@32061|Chloroflexia	32061|Chloroflexia	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
CMS2_k127_669685_10	313628.LNTAR_17668	4.051e-05	55.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_669685_9	1333998.M2A_2762	6.247e-11	71.0	2ECIU@1|root,336GZ@2|Bacteria,1NEYG@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_669685_7	595460.RRSWK_06101	1.121e-17	96.0	COG3385@1|root,COG3385@2|Bacteria,2IZE5@203682|Planctomycetes	203682|Planctomycetes	L	COG5659 FOG Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
CMS2_k127_669685_2	1276920.ADIAG_03946	1.385e-44	173.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
CMS2_k127_669685_11	7668.SPU_022974-tr	0.0001562	54.0	KOG1217@1|root,KOG1217@2759|Eukaryota,3ATCV@33154|Opisthokonta,3C49M@33208|Metazoa,3DE0Z@33213|Bilateria	33208|Metazoa	T	Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)	svep1	-	-	ko:K17495	-	-	-	-	ko00000,ko01009	-	-	-	EGF,EGF_CA,Ephrin_rec_like,HYR,Pentaxin,Sushi,VWA,hEGF
CMS2_k127_669685_5	348824.LPU83_1713	7.315e-22	99.0	COG3405@1|root,COG3405@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 8 (cellulase D) family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C
CMS2_k127_669685_12	562970.Btus_2106	0.0001668	44.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1U2YN@1239|Firmicutes,4HX7V@91061|Bacilli,27A4T@186823|Alicyclobacillaceae	91061|Bacilli	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
CMS2_k127_6734413_16	240016.ABIZ01000001_gene2631	1.173e-35	149.0	COG4745@1|root,COG4745@2|Bacteria,46T45@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS2_k127_6734413_12	1396418.BATQ01000117_gene4549	5.169e-65	235.0	COG1477@1|root,COG1477@2|Bacteria,46VJI@74201|Verrucomicrobia,2IW89@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	ApbE family	-	-	-	-	-	-	-	-	-	-	-	-	ApbE
CMS2_k127_6734413_15	671143.DAMO_0313	1.87e-37	150.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_6734413_6	1304284.L21TH_0118	5.485e-104	352.0	COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,36E72@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS2_k127_6734413_8	767817.Desgi_2508	1.082e-85	299.0	COG1694@1|root,COG4198@1|root,COG1694@2|Bacteria,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,2617E@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
CMS2_k127_6734413_0	1123274.KB899413_gene777	1.905e-203	647.0	COG0493@1|root,COG0493@2|Bacteria,2J5FP@203691|Spirochaetes	203691|Spirochaetes	C	glutamate synthase (NADPH), homotetrameric	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
CMS2_k127_6734413_5	744872.Spica_0134	1.514e-106	352.0	COG0543@1|root,COG0543@2|Bacteria,2J5SH@203691|Spirochaetes	203691|Spirochaetes	C	Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
CMS2_k127_6734413_17	1442599.JAAN01000041_gene3135	2.153e-34	134.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,1X6WB@135614|Xanthomonadales	135614|Xanthomonadales	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS2_k127_6734413_14	247490.KSU1_B0617	1.37e-53	200.0	COG1354@1|root,COG1354@2|Bacteria,2IZIR@203682|Planctomycetes	203682|Planctomycetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
CMS2_k127_6734413_3	644282.Deba_2027	3.014e-115	379.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
CMS2_k127_6734413_1	278957.ABEA03000005_gene4380	5.765e-156	503.0	COG0407@1|root,COG0407@2|Bacteria,46WW7@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
CMS2_k127_6734413_13	926556.Echvi_0410	1.921e-59	214.0	COG2188@1|root,COG2188@2|Bacteria,4PJQ8@976|Bacteroidetes,47PR4@768503|Cytophagia	976|Bacteroidetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
CMS2_k127_6734413_4	1238450.VIBNISOn1_280037	1.629e-114	377.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RWHU@1236|Gammaproteobacteria,1Y26H@135623|Vibrionales	1224|Proteobacteria	C	Dehydrogenase E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
CMS2_k127_6734413_2	1238450.VIBNISOn1_280038	2.541e-131	431.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1XV36@135623|Vibrionales	135623|Vibrionales	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	pdhB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS2_k127_6734413_7	697281.Mahau_1309	2.976e-87	298.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,42EMP@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM ketose-bisphosphate aldolase, class-II	-	-	4.1.2.13,4.1.2.40	ko:K01624,ko:K08302	ko00010,ko00030,ko00051,ko00052,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01069,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
CMS2_k127_6734413_9	215803.DB30_6687	1.228e-84	295.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,42RDN@68525|delta/epsilon subdivisions,2WMR0@28221|Deltaproteobacteria,2YUAJ@29|Myxococcales	28221|Deltaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CMS2_k127_6734413_10	3218.PP1S245_2V6.1	1.127e-77	267.0	COG0637@1|root,KOG2914@2759|Eukaryota,37KNJ@33090|Viridiplantae,3G8EX@35493|Streptophyta	35493|Streptophyta	S	Haloacid dehalogenase-like hydrolase domain-containing protein At3g48420	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464	-	-	-	-	-	-	-	-	-	-	HAD_2
CMS2_k127_6734413_11	1408473.JHXO01000011_gene2970	2.464e-69	246.0	COG0524@1|root,COG0524@2|Bacteria,4NGFK@976|Bacteroidetes,2FN72@200643|Bacteroidia	976|Bacteroidetes	G	Kinase, PfkB family	ydjH_1	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CMS2_k127_6754030_0	693979.Bache_0230	6.062e-27	128.0	28KYZ@1|root,2ZAEB@2|Bacteria,4NHBZ@976|Bacteroidetes,2FP4X@200643|Bacteroidia,4AMVW@815|Bacteroidaceae	976|Bacteroidetes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_67660_5	335543.Sfum_2158	5.386e-32	143.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
CMS2_k127_67660_0	313628.LNTAR_07649	1.62e-262	848.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored,TAT_signal
CMS2_k127_67660_2	240016.ABIZ01000001_gene4842	3.358e-131	426.0	COG2115@1|root,COG2115@2|Bacteria	2|Bacteria	G	xylose isomerase activity	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
CMS2_k127_67660_7	1445613.JALM01000009_gene645	0.000539	43.0	COG2120@1|root,COG2120@2|Bacteria,2GJP3@201174|Actinobacteria,4EBMR@85010|Pseudonocardiales	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS2_k127_67660_4	1123242.JH636434_gene3955	2.473e-57	206.0	COG2120@1|root,COG2120@2|Bacteria,2IYPC@203682|Planctomycetes	203682|Planctomycetes	S	LmbE homologs	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS2_k127_67660_1	1123248.KB893385_gene4912	9.617e-160	509.0	COG0363@1|root,COG0363@2|Bacteria,4P0EP@976|Bacteroidetes	976|Bacteroidetes	G	glucosamine-6-phosphate deaminase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_67660_6	575540.Isop_0083	2.804e-08	66.0	COG0524@1|root,COG0524@2|Bacteria,2IX8I@203682|Planctomycetes	203682|Planctomycetes	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CMS2_k127_67660_3	1121481.AUAS01000001_gene4864	3.164e-86	290.0	COG2017@1|root,COG2017@2|Bacteria,4NHQH@976|Bacteroidetes,47JMF@768503|Cytophagia	976|Bacteroidetes	G	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
CMS2_k127_6775496_9	634452.APA01_12410	4.516e-05	48.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,2JQ5V@204441|Rhodospirillales	204441|Rhodospirillales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
CMS2_k127_6775496_6	886293.Sinac_6056	3.889e-38	149.0	COG1259@1|root,COG1259@2|Bacteria,2IZNE@203682|Planctomycetes	203682|Planctomycetes	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
CMS2_k127_6775496_7	247490.KSU1_D0650	1.137e-18	93.0	COG0597@1|root,COG0597@2|Bacteria,2J0RI@203682|Planctomycetes	203682|Planctomycetes	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
CMS2_k127_6775496_8	5888.CAK74901	1.164e-13	83.0	COG3914@1|root,KOG4626@2759|Eukaryota,3ZB2N@5878|Ciliophora	5878|Ciliophora	GOT	Encoded by	-	-	-	ko:K18626	-	-	-	-	ko00000,ko04812	-	-	-	TPR_16,TPR_2,TPR_8
CMS2_k127_6775496_0	635013.TherJR_2708	9.799e-179	576.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,2602C@186807|Peptococcaceae	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
CMS2_k127_6775496_4	404380.Gbem_0317	3.101e-42	157.0	COG1917@1|root,COG1917@2|Bacteria,1MZD8@1224|Proteobacteria,42W0P@68525|delta/epsilon subdivisions,2WRDR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS2_k127_6775496_1	575540.Isop_1688	3.503e-135	451.0	COG0323@1|root,COG0323@2|Bacteria,2IXI2@203682|Planctomycetes	203682|Planctomycetes	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
CMS2_k127_6775496_5	56780.SYN_01423	4.352e-42	166.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,42PQA@68525|delta/epsilon subdivisions,2WKNZ@28221|Deltaproteobacteria,2MR8B@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
CMS2_k127_6775496_2	330214.NIDE2673	4.324e-68	245.0	COG0609@1|root,COG0609@2|Bacteria,3J11Y@40117|Nitrospirae	40117|Nitrospirae	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
CMS2_k127_6775496_3	1041930.Mtc_1719	3.984e-51	199.0	COG1120@1|root,arCOG00199@2157|Archaea,2XTTV@28890|Euryarchaeota,2NA71@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS2_k127_6776343_11	1123489.AUAN01000005_gene1609	4.659e-28	116.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,4H2M3@909932|Negativicutes	909932|Negativicutes	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
CMS2_k127_6776343_1	1210884.HG799462_gene8559	1.024e-176	571.0	COG2804@1|root,COG2804@2|Bacteria,2IXSA@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
CMS2_k127_6776343_3	1142394.PSMK_15850	9.059e-149	479.0	COG2805@1|root,COG2805@2|Bacteria,2IXRP@203682|Planctomycetes	203682|Planctomycetes	NU	COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS2_k127_6776343_0	1142394.PSMK_20220	2.408e-222	703.0	COG2804@1|root,COG2804@2|Bacteria,2IXGK@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
CMS2_k127_6776343_5	1142394.PSMK_20230	1.465e-110	370.0	COG1459@1|root,COG1459@2|Bacteria,2IX2A@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway component PulF	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
CMS2_k127_6776343_19	243090.RB5089	3.695e-05	55.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_6776343_18	1142394.PSMK_20870	2.897e-06	59.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_6776343_20	1121468.AUBR01000025_gene2997	4.144e-05	52.0	COG4968@1|root,COG4968@2|Bacteria,1VFJ7@1239|Firmicutes,24SXX@186801|Clostridia,42HI6@68295|Thermoanaerobacterales	186801|Clostridia	U	Type II secretion system (T2SS), protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
CMS2_k127_6776343_15	247490.KSU1_C1462	1.229e-09	72.0	2EWE5@1|root,33PSP@2|Bacteria,2J1V0@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6776343_8	1227454.C446_05270	2.714e-35	152.0	COG0061@1|root,COG0483@1|root,arCOG01348@2157|Archaea,arCOG01349@2157|Archaea,2XSW9@28890|Euryarchaeota,23T65@183963|Halobacteria	183963|Halobacteria	GH	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	suhB2	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P,NAD_kinase
CMS2_k127_6776343_17	1142394.PSMK_02520	5.619e-08	61.0	2E3B2@1|root,32YAK@2|Bacteria,2J19J@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
CMS2_k127_6776343_4	886293.Sinac_6245	7.541e-144	474.0	COG1052@1|root,COG1052@2|Bacteria,2J557@203682|Planctomycetes	203682|Planctomycetes	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
CMS2_k127_6776343_6	1142394.PSMK_27380	2.902e-102	349.0	COG1109@1|root,COG1109@2|Bacteria,2IXRS@203682|Planctomycetes	203682|Planctomycetes	G	PFAM Phosphoglucomutase phosphomannomutase, alpha beta alpha domain	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS2_k127_6776343_7	1122211.JMLW01000004_gene2657	1.228e-59	218.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1XH3K@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
CMS2_k127_6776343_12	755732.Fluta_2064	1.715e-24	120.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.4.21.50	ko:K01337	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CHU_C,PKD,Peptidase_M43,SprB
CMS2_k127_6776343_13	1121403.AUCV01000058_gene3038	2.536e-16	94.0	COG1520@1|root,COG3866@1|root,COG1520@2|Bacteria,COG3866@2|Bacteria	2|Bacteria	G	Pectate lyase	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Big_2,CHU_C,DUF285,HYR,fn3
CMS2_k127_6776343_10	13035.Dacsa_2125	1.531e-31	145.0	COG1028@1|root,COG2931@1|root,COG5306@1|root,COG1028@2|Bacteria,COG2931@2|Bacteria,COG5306@2|Bacteria,1G2IN@1117|Cyanobacteria	1117|Cyanobacteria	IQ	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6776343_16	1121101.HMPREF1532_00978	2.908e-09	71.0	COG3119@1|root,COG3866@1|root,COG3119@2|Bacteria,COG3866@2|Bacteria,4NJUK@976|Bacteroidetes,2FR5P@200643|Bacteroidia,4ATC8@815|Bacteroidaceae	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6776343_9	1121904.ARBP01000025_gene6084	1.395e-33	151.0	COG1404@1|root,COG2273@1|root,COG2730@1|root,COG2911@1|root,COG4733@1|root,COG1404@2|Bacteria,COG2273@2|Bacteria,COG2730@2|Bacteria,COG2911@2|Bacteria,COG4733@2|Bacteria,4NHHA@976|Bacteroidetes,47XBX@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,CHU_C,Calx-beta,He_PIG,NHL,TIG,fn3
CMS2_k127_6776343_2	1094508.Tsac_1049	2.17e-168	537.0	COG1454@1|root,COG1454@2|Bacteria,1UY3E@1239|Firmicutes,25E9A@186801|Clostridia,42GFI@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
CMS2_k127_6776343_14	1034769.KB910518_gene1041	1.515e-15	84.0	COG1621@1|root,COG3204@1|root,COG3533@1|root,COG3940@1|root,COG1621@2|Bacteria,COG3204@2|Bacteria,COG3533@2|Bacteria,COG3940@2|Bacteria,1U157@1239|Firmicutes,4HT9T@91061|Bacilli,26UV2@186822|Paenibacillaceae	91061|Bacilli	G	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,Laminin_G_3
CMS2_k127_6785032_3	1242864.D187_008147	4.507e-92	311.0	COG2304@1|root,COG2304@2|Bacteria,1MXU0@1224|Proteobacteria,42M41@68525|delta/epsilon subdivisions,2WMM8@28221|Deltaproteobacteria,2YY7C@29|Myxococcales	28221|Deltaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	VWA
CMS2_k127_6785032_2	886293.Sinac_1816	3.269e-96	343.0	COG2304@1|root,COG2304@2|Bacteria,2IY1T@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA,VWA_3
CMS2_k127_6785032_4	272560.BPSL1666	1.064e-05	59.0	COG0457@1|root,COG0500@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,COG2226@2|Bacteria,1MUZK@1224|Proteobacteria,2VJNV@28216|Betaproteobacteria,1K0WR@119060|Burkholderiaceae	28216|Betaproteobacteria	M	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_16
CMS2_k127_6785032_1	1499967.BAYZ01000102_gene3561	6.236e-116	411.0	COG4262@1|root,COG4262@2|Bacteria,2NS3W@2323|unclassified Bacteria	2|Bacteria	S	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_1,Spermine_synth
CMS2_k127_6785032_0	1168034.FH5T_03280	1.119e-137	461.0	COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	dppX	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
CMS2_k127_6796582_3	1307759.JOMJ01000003_gene1765	2.386e-106	351.0	COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,42PJV@68525|delta/epsilon subdivisions,2WKRG@28221|Deltaproteobacteria,2M98V@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM MscS Mechanosensitive ion channel	-	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
CMS2_k127_6796582_2	247490.KSU1_C0203	1.259e-141	460.0	COG0598@1|root,COG0598@2|Bacteria,2IX61@203682|Planctomycetes	203682|Planctomycetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
CMS2_k127_6796582_8	1047013.AQSP01000119_gene1318	2.811e-55	210.0	COG4843@1|root,COG4843@2|Bacteria,2NPKB@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179
CMS2_k127_6796582_5	1232410.KI421424_gene1601	1.304e-77	272.0	COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria,43SCM@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
CMS2_k127_6796582_4	1403819.BATR01000118_gene4086	3.936e-93	318.0	COG1723@1|root,COG1723@2|Bacteria	2|Bacteria	S	PFAM Uncharacterised ACR, YagE family COG1723	yagE	-	-	-	-	-	-	-	-	-	-	-	DUF155
CMS2_k127_6796582_6	865937.Gilli_3118	1.227e-64	228.0	COG2120@1|root,COG2120@2|Bacteria,4NM6J@976|Bacteroidetes,1I57Z@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS2_k127_6796582_9	1408473.JHXO01000008_gene2652	5.422e-52	188.0	COG0438@1|root,COG0438@2|Bacteria,4NKIM@976|Bacteroidetes	976|Bacteroidetes	M	Pfam Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
CMS2_k127_6796582_0	485913.Krac_9382	4.876e-286	894.0	COG1505@1|root,COG1505@2|Bacteria,2GBNH@200795|Chloroflexi	200795|Chloroflexi	E	Peptidase S9, prolyl oligopeptidase active site domain protein	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
CMS2_k127_6796582_10	742726.HMPREF9448_00853	5.093e-09	68.0	COG1409@1|root,COG1520@1|root,COG1409@2|Bacteria,COG1520@2|Bacteria,4NFA9@976|Bacteroidetes,2FPAX@200643|Bacteroidia,22X7X@171551|Porphyromonadaceae	976|Bacteroidetes	S	PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,PQQ,PQQ_2,PQQ_3
CMS2_k127_6796582_1	247490.KSU1_D0628	2.446e-172	556.0	COG0138@1|root,COG0138@2|Bacteria,2IXB5@203682|Planctomycetes	203682|Planctomycetes	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
CMS2_k127_6796582_7	247490.KSU1_B0405	2.361e-58	211.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
CMS2_k127_6804303_3	344747.PM8797T_28974	1.809e-06	59.0	COG1277@1|root,COG1277@2|Bacteria,2J0UB@203682|Planctomycetes	203682|Planctomycetes	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
CMS2_k127_6804303_2	886293.Sinac_7590	1.716e-09	70.0	COG1277@1|root,COG1277@2|Bacteria,2J2SG@203682|Planctomycetes	2|Bacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2,ABC2_membrane_3
CMS2_k127_6804303_1	886293.Sinac_2826	1.82e-16	93.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2,ABC2_membrane_3
CMS2_k127_6804303_0	575540.Isop_1673	4.195e-97	326.0	COG1131@1|root,COG1131@2|Bacteria,2IXFI@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_6804303_4	1128421.JAGA01000002_gene170	9.357e-06	57.0	COG5426@1|root,COG5426@2|Bacteria	2|Bacteria	D	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6812674_20	521674.Plim_3544	2.31e-24	103.0	COG0115@1|root,COG0115@2|Bacteria,2IY3N@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CMS2_k127_6812674_9	530564.Psta_0644	4.086e-64	238.0	COG1136@1|root,COG1136@2|Bacteria,2IYZ3@203682|Planctomycetes	203682|Planctomycetes	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
CMS2_k127_6812674_23	859653.HIMB5_00005600	8.834e-10	71.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,4BPKM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
CMS2_k127_6812674_17	391165.GbCGDNIH1_1283	2.74e-28	130.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,2JPQR@204441|Rhodospirillales	204441|Rhodospirillales	M	COG4591 ABC-type transport system, involved in lipoprotein release, permease component	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
CMS2_k127_6812674_0	575540.Isop_2677	4.805e-162	525.0	COG1190@1|root,COG1190@2|Bacteria,2IXHX@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
CMS2_k127_6812674_6	1142394.PSMK_15360	2.985e-71	269.0	COG0793@1|root,COG0793@2|Bacteria,2IX9Q@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
CMS2_k127_6812674_2	1209989.TepiRe1_1813	7.379e-126	410.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,42EMP@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM ketose-bisphosphate aldolase, class-II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
CMS2_k127_6812674_8	344747.PM8797T_13103	1.093e-64	252.0	COG1452@1|root,COG1452@2|Bacteria,2IXFV@203682|Planctomycetes	203682|Planctomycetes	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	OstA_C
CMS2_k127_6812674_21	575540.Isop_1769	1.521e-12	71.0	2E607@1|root,330PM@2|Bacteria,2J0MD@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6812674_5	583355.Caka_3034	2.483e-97	331.0	COG2805@1|root,COG2805@2|Bacteria,46S5Q@74201|Verrucomicrobia,3K79X@414999|Opitutae	414999|Opitutae	NU	twitching motility protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS2_k127_6812674_11	237368.SCABRO_02563	2.247e-55	199.0	COG2078@1|root,COG2078@2|Bacteria,2J349@203682|Planctomycetes	203682|Planctomycetes	S	AMMECR1	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1
CMS2_k127_6812674_10	1232410.KI421413_gene667	1.007e-63	226.0	COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,42TAU@68525|delta/epsilon subdivisions,2WPD6@28221|Deltaproteobacteria,43UN9@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS2_k127_6812674_14	1235279.C772_02985	8.948e-46	177.0	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,4HAV8@91061|Bacilli,26D7H@186818|Planococcaceae	91061|Bacilli	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096,M00582	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.29	-	iYO844.BSU00460	GHMP_kinases_C,GHMP_kinases_N
CMS2_k127_6812674_12	1123242.JH636438_gene5810	6.844e-49	178.0	COG2088@1|root,COG2088@2|Bacteria,2IZR8@203682|Planctomycetes	203682|Planctomycetes	D	Belongs to the SpoVG family	-	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
CMS2_k127_6812674_27	886293.Sinac_1140	0.0003476	48.0	COG2747@1|root,COG2747@2|Bacteria,2J17Q@203682|Planctomycetes	203682|Planctomycetes	KNU	PFAM Anti-sigma-28 factor FlgM	-	-	-	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgM
CMS2_k127_6812674_26	404589.Anae109_0722	6.023e-05	55.0	COG4972@1|root,COG4972@2|Bacteria,1MYIB@1224|Proteobacteria,42SIX@68525|delta/epsilon subdivisions,2WP1G@28221|Deltaproteobacteria,2YVKD@29|Myxococcales	28221|Deltaproteobacteria	NU	Type IV pilus assembly protein PilM;	gspL	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspL_C,PilM_2,PilN,T2SSL
CMS2_k127_6812674_16	349521.HCH_03935	9.519e-31	126.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1XKIP@135619|Oceanospirillales	135619|Oceanospirillales	U	secretion system protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
CMS2_k127_6812674_7	391625.PPSIR1_25856	5.902e-67	245.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2YTZT@29|Myxococcales	28221|Deltaproteobacteria	U	General secretion pathway protein F	gspF	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
CMS2_k127_6812674_1	1125863.JAFN01000001_gene2969	1.576e-159	520.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	PFAM Type II secretion system protein E	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
CMS2_k127_6812674_19	1304872.JAGC01000009_gene596	2.324e-26	128.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,2M98X@213115|Desulfovibrionales	28221|Deltaproteobacteria	NU	PFAM type II and III secretion system protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
CMS2_k127_6812674_13	237368.SCABRO_01223	4.353e-47	187.0	COG0737@1|root,COG0737@2|Bacteria,2IXWK@203682|Planctomycetes	203682|Planctomycetes	C	5'-nucleotidase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
CMS2_k127_6812674_22	1410608.JNKX01000002_gene1923	6.549e-11	74.0	2CG1Y@1|root,31NHZ@2|Bacteria,4NQ9Z@976|Bacteroidetes,2FSBR@200643|Bacteroidia,4AWC6@815|Bacteroidaceae	976|Bacteroidetes	S	Protein of unknown function (DUF1573)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
CMS2_k127_6812674_18	1125863.JAFN01000001_gene1727	3.035e-27	112.0	COG0254@1|root,COG0254@2|Bacteria,1PT0H@1224|Proteobacteria,42V2Z@68525|delta/epsilon subdivisions,2WRGA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
CMS2_k127_6812674_3	555779.Dthio_PD2394	2.795e-106	359.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2M8U2@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CMS2_k127_6812674_4	1142394.PSMK_11820	9.93e-100	338.0	COG2019@1|root,COG2019@2|Bacteria	2|Bacteria	F	adenylate kinase activity	-	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
CMS2_k127_6812674_15	380703.AHA_2738	1.609e-43	159.0	COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,1S7UR@1236|Gammaproteobacteria,1Y4GF@135624|Aeromonadales	135624|Aeromonadales	S	Putative member of DMT superfamily (DUF486)	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
CMS2_k127_683923_3	1408444.JHYC01000013_gene2473	1.579e-05	49.0	2BNP9@1|root,32HCB@2|Bacteria,1QBYA@1224|Proteobacteria,1T7JI@1236|Gammaproteobacteria,1JFGD@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_683923_0	706587.Desti_0377	3.923e-145	474.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2WJ3T@28221|Deltaproteobacteria,2MQAM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS2_k127_683923_1	344747.PM8797T_19465	2.061e-95	325.0	COG0438@1|root,COG0438@2|Bacteria,2J2RZ@203682|Planctomycetes	203682|Planctomycetes	M	Domain of unknown function (DUF3524)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3524,Glycos_transf_1
CMS2_k127_683923_2	644282.Deba_0582	7.77e-26	112.0	COG1633@1|root,COG1633@2|Bacteria,1N4PW@1224|Proteobacteria,42UZG@68525|delta/epsilon subdivisions,2WNGQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS2_k127_6856426_2	929713.NIASO_15665	1.555e-48	193.0	COG3356@1|root,COG3356@2|Bacteria,4NUXP@976|Bacteroidetes	976|Bacteroidetes	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
CMS2_k127_6856426_3	497964.CfE428DRAFT_0725	5.155e-32	142.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
CMS2_k127_6856426_1	234267.Acid_6247	3.17e-80	284.0	COG0673@1|root,COG0673@2|Bacteria,3Y39X@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_6856426_4	880073.Calab_1872	3.432e-29	137.0	COG3630@1|root,COG5337@1|root,COG3630@2|Bacteria,COG5337@2|Bacteria	2|Bacteria	M	Spore coat protein CotH	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Fn3_assoc,LTD,OAD_gamma
CMS2_k127_6856426_0	1396141.BATP01000030_gene3715	5.33e-120	423.0	COG2010@1|root,COG2312@1|root,COG5337@1|root,COG5563@1|root,COG2010@2|Bacteria,COG2312@2|Bacteria,COG5337@2|Bacteria,COG5563@2|Bacteria,46XD5@74201|Verrucomicrobia,2IVHX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Fn3_assoc,LTD
CMS2_k127_6862658_3	1382305.AZUC01000047_gene1013	8.56e-22	105.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,26E4T@186818|Planococcaceae	91061|Bacilli	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
CMS2_k127_6862658_4	243090.RB4769	7.253e-10	70.0	28MMN@1|root,2ZAXE@2|Bacteria,2IY1P@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6862658_2	926550.CLDAP_21940	2.546e-24	104.0	COG5428@1|root,COG5428@2|Bacteria,2G9DH@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
CMS2_k127_6862658_1	1380394.JADL01000005_gene5553	5.226e-86	289.0	COG1051@1|root,COG1051@2|Bacteria,1RH0I@1224|Proteobacteria,2UB84@28211|Alphaproteobacteria,2JWEM@204441|Rhodospirillales	204441|Rhodospirillales	F	Hydrolase of X-linked nucleoside diphosphate N terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N
CMS2_k127_6862658_5	404589.Anae109_3529	1.011e-09	70.0	2CA5X@1|root,33BSQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6862658_0	247490.KSU1_C1241	4.243e-124	406.0	COG1217@1|root,COG1217@2|Bacteria,2IY3Q@203682|Planctomycetes	203682|Planctomycetes	T	membrane GTPase involved in stress response	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
CMS2_k127_6867675_1	1142394.PSMK_14630	4.687e-101	342.0	COG2805@1|root,COG2805@2|Bacteria,2IX6Y@203682|Planctomycetes	203682|Planctomycetes	NU	twitching motility protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS2_k127_6867675_2	521674.Plim_0082	6.999e-74	269.0	COG2804@1|root,COG2804@2|Bacteria,2IXVD@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE
CMS2_k127_6867675_0	1149133.ppKF707_2739	8.449e-185	599.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1YFG7@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS2_k127_687028_0	471854.Dfer_4315	7.213e-32	134.0	2DBYP@1|root,2ZBWI@2|Bacteria,4PPYC@976|Bacteroidetes,47PBE@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_687028_3	314278.NB231_08335	0.0006089	44.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,1RRFT@1236|Gammaproteobacteria,1WZIC@135613|Chromatiales	135613|Chromatiales	L	COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
CMS2_k127_687028_2	1453505.JASY01000006_gene1259	2.61e-05	57.0	COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,1I0G9@117743|Flavobacteriia,2NTFA@237|Flavobacterium	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_687028_1	1142394.PSMK_24760	3.769e-06	57.0	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_687728_1	580331.Thit_0487	6.608e-38	144.0	COG0863@1|root,COG0863@2|Bacteria,1TPR7@1239|Firmicutes,24A3P@186801|Clostridia,42ESE@68295|Thermoanaerobacterales	186801|Clostridia	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
CMS2_k127_687728_4	13035.Dacsa_0769	1.945e-11	70.0	2E7CY@1|root,331W4@2|Bacteria,1GA19@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_687728_2	41431.PCC8801_3531	7.112e-22	97.0	2E46S@1|root,32Z2Q@2|Bacteria,1GACN@1117|Cyanobacteria,3KKRE@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_687728_0	234267.Acid_5325	2.805e-206	650.0	COG0673@1|root,COG0673@2|Bacteria,3Y7B1@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_687728_6	1288079.AUKN01000018_gene2547	0.0003695	46.0	COG0642@1|root,COG2205@2|Bacteria,2GM17@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	mprB	-	2.7.13.3	ko:K07653	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
CMS2_k127_687728_5	579405.Dd703_3217	6.825e-07	53.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,2JDAS@204037|Dickeya	1236|Gammaproteobacteria	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iEcSMS35_1347.EcSMS35_2767	NAD_kinase
CMS2_k127_6896773_3	1403819.BATR01000061_gene1861	2.359e-21	111.0	COG1511@1|root,COG1511@2|Bacteria,46VD9@74201|Verrucomicrobia,2IVFT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6896773_5	314230.DSM3645_26669	6.157e-11	76.0	COG2304@1|root,COG2304@2|Bacteria	314230.DSM3645_26669|-	IU	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6896773_1	880073.Calab_3696	6.449e-89	302.0	COG1721@1|root,COG1721@2|Bacteria,2NP6B@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS2_k127_6896773_0	1379698.RBG1_1C00001G0201	1.163e-113	376.0	COG0714@1|root,COG0714@2|Bacteria,2NNV8@2323|unclassified Bacteria	2|Bacteria	O	ATPase family associated with various cellular activities (AAA)	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS2_k127_6896773_2	439235.Dalk_2288	1.459e-32	138.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,2MPW6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4150,RHS,RHS_repeat,Transglut_core
CMS2_k127_6896773_4	1123508.JH636440_gene2494	2.319e-12	78.0	2DCAX@1|root,2ZDGW@2|Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
CMS2_k127_6906333_3	1142394.PSMK_15440	2.159e-49	196.0	COG0706@1|root,COG0706@2|Bacteria,2IYA0@203682|Planctomycetes	203682|Planctomycetes	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,PDZ_2,YidC_periplas
CMS2_k127_6906333_1	1123257.AUFV01000003_gene1044	1.081e-57	219.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1X3DW@135614|Xanthomonadales	135614|Xanthomonadales	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
CMS2_k127_6906333_2	932678.THERU_04040	1.469e-49	191.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS2_k127_6906333_0	237368.SCABRO_03963	1.131e-281	878.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
CMS2_k127_6934204_0	497964.CfE428DRAFT_4416	2.887e-231	722.0	COG3119@1|root,COG3119@2|Bacteria,46U45@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_6934204_7	324925.Ppha_1324	2.931e-15	79.0	COG1433@1|root,COG1433@2|Bacteria,1FF7W@1090|Chlorobi	1090|Chlorobi	S	PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
CMS2_k127_6934204_4	1173029.JH980292_gene533	3.919e-40	161.0	COG0860@1|root,COG0860@2|Bacteria,1G008@1117|Cyanobacteria,1H876@1150|Oscillatoriales	1117|Cyanobacteria	M	N-acetylmuramoyl-L-alanine amidase	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
CMS2_k127_6934204_5	1303518.CCALI_01258	1.455e-18	94.0	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_6934204_6	215803.DB30_0968	2.332e-15	85.0	COG0735@1|root,COG0735@2|Bacteria,1NCW6@1224|Proteobacteria,42XS7@68525|delta/epsilon subdivisions,2WTAU@28221|Deltaproteobacteria,2YV43@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS2_k127_6934204_2	426368.MmarC7_1556	1.423e-50	188.0	arCOG06621@1|root,arCOG06621@2157|Archaea,2Y3GZ@28890|Euryarchaeota,23RKE@183939|Methanococci	183939|Methanococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6934204_8	1527444.ucyna2_00727	5.99e-06	56.0	COG0785@1|root,COG0785@2|Bacteria,1G0FI@1117|Cyanobacteria	1117|Cyanobacteria	O	cytochrome c biogenesis protein	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
CMS2_k127_6934204_9	867845.KI911784_gene2035	4.589e-05	53.0	COG0457@1|root,COG0457@2|Bacteria,2GAB4@200795|Chloroflexi,374UY@32061|Chloroflexia	32061|Chloroflexia	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_2
CMS2_k127_6934204_1	1122622.ATWJ01000007_gene1910	3.57e-55	206.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4FEHC@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the ribF family	ribF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
CMS2_k127_6934204_3	521674.Plim_0422	1.016e-48	185.0	COG0618@1|root,COG0618@2|Bacteria,2IYQ0@203682|Planctomycetes	203682|Planctomycetes	S	phosphoesterase RecJ domain protein	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
CMS2_k127_6950222_6	1123389.ATXJ01000019_gene4	5.187e-37	148.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_6950222_9	595460.RRSWK_00504	1.202e-13	77.0	COG0628@1|root,COG0628@2|Bacteria,2J103@203682|Planctomycetes	203682|Planctomycetes	S	membrane protein-putative a permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CMS2_k127_6950222_7	765913.ThidrDRAFT_1299	5.25e-31	124.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1WYGH@135613|Chromatiales	135613|Chromatiales	S	PFAM RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS2_k127_6950222_5	331113.SNE_A18970	2.819e-45	175.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,MerR_1,RDD
CMS2_k127_6950222_2	1303518.CCALI_01571	2.754e-178	581.0	COG1501@1|root,COG1501@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	He_PIG,He_PIG_assoc,Melibiase_2,Melibiase_2_C,NPCBM
CMS2_k127_6950222_12	1303518.CCALI_00548	4.963e-07	61.0	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_6950222_8	237368.SCABRO_02983	2.477e-26	110.0	2E71C@1|root,331K1@2|Bacteria,2J130@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6950222_10	1121934.AUDX01000013_gene1774	2.51e-11	79.0	COG1158@1|root,COG3204@1|root,COG1158@2|Bacteria,COG3204@2|Bacteria,2I94U@201174|Actinobacteria,4FN98@85023|Microbacteriaceae	201174|Actinobacteria	K	Esterase-like activity of phytase	-	-	-	-	-	-	-	-	-	-	-	-	LTD,Phytase-like
CMS2_k127_6950222_1	1396141.BATP01000030_gene3715	8.541e-179	626.0	COG2010@1|root,COG2312@1|root,COG5337@1|root,COG5563@1|root,COG2010@2|Bacteria,COG2312@2|Bacteria,COG5337@2|Bacteria,COG5563@2|Bacteria,46XD5@74201|Verrucomicrobia,2IVHX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Fn3_assoc,LTD
CMS2_k127_6950222_0	243164.DET1061	4.144e-180	575.0	COG1236@1|root,COG1236@2|Bacteria,2G62G@200795|Chloroflexi,34D19@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B_6,RMMBL
CMS2_k127_6950222_3	1396418.BATQ01000017_gene4177	2.096e-118	396.0	COG0673@1|root,COG0673@2|Bacteria,46U95@74201|Verrucomicrobia,2IVCR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_6950222_4	886293.Sinac_5304	8.025e-118	396.0	COG0477@1|root,COG2814@2|Bacteria,2IY3A@203682|Planctomycetes	203682|Planctomycetes	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
CMS2_k127_6950222_11	391612.CY0110_06259	6.865e-11	72.0	28N8A@1|root,2ZBCR@2|Bacteria,1G2Q6@1117|Cyanobacteria,3KHEW@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6956813_9	794903.OPIT5_13005	2.514e-12	77.0	COG2165@1|root,COG2165@2|Bacteria,46Z5T@74201|Verrucomicrobia,3K9RI@414999|Opitutae	414999|Opitutae	U	Protein of unknown function (DUF1559)	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
CMS2_k127_6956813_4	1173024.KI912149_gene5698	2.018e-55	201.0	COG1881@1|root,COG1881@2|Bacteria,1G5SZ@1117|Cyanobacteria,1JKN4@1189|Stigonemataceae	1117|Cyanobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
CMS2_k127_6956813_2	1499967.BAYZ01000056_gene4902	7.749e-74	257.0	COG1237@1|root,COG1237@2|Bacteria,2NPQA@2323|unclassified Bacteria	2|Bacteria	P	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Lactamase_B_2
CMS2_k127_6956813_5	497964.CfE428DRAFT_3208	9.401e-27	121.0	COG1082@1|root,COG1082@2|Bacteria,46V05@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS2_k127_6956813_10	439235.Dalk_0886	2.046e-11	76.0	COG1453@1|root,COG1453@2|Bacteria,1QZ5K@1224|Proteobacteria,43CG9@68525|delta/epsilon subdivisions,2X7RA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
CMS2_k127_6956813_11	204669.Acid345_2664	0.00041	49.0	COG3063@1|root,COG3063@2|Bacteria,3Y4EX@57723|Acidobacteria,2JKPQ@204432|Acidobacteriia	204432|Acidobacteriia	NU	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
CMS2_k127_6956813_0	314230.DSM3645_11382	2.612e-215	690.0	COG3119@1|root,COG3119@2|Bacteria,2IX2H@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.14	ko:K01137	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078,M00079	R07808,R07819	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4976,Sulfatase
CMS2_k127_6956813_1	641524.ADICYQ_5692	1.79e-80	287.0	COG3119@1|root,COG3119@2|Bacteria,4NE7S@976|Bacteroidetes	976|Bacteroidetes	P	COG COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS2_k127_6956813_6	886293.Sinac_5415	1.395e-23	105.0	295T6@1|root,2ZT4D@2|Bacteria,2J4MB@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6956813_8	479435.Kfla_5280	4.474e-16	89.0	COG4409@1|root,COG4409@2|Bacteria,2I0CJ@201174|Actinobacteria,4DS0V@85009|Propionibacteriales	201174|Actinobacteria	G	BNR repeat-like domain	-	-	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Laminin_G_3
CMS2_k127_6956813_7	886293.Sinac_5415	1.761e-21	101.0	295T6@1|root,2ZT4D@2|Bacteria,2J4MB@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6956813_3	344747.PM8797T_07764	1.104e-70	244.0	COG0422@1|root,COG0422@2|Bacteria,2IWV7@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
CMS2_k127_69641_1	794903.OPIT5_29480	2.177e-27	130.0	COG0526@1|root,COG2373@1|root,COG4219@1|root,COG0526@2|Bacteria,COG2373@2|Bacteria,COG4219@2|Bacteria,46XN8@74201|Verrucomicrobia,3K9XB@414999|Opitutae	414999|Opitutae	KT	BlaR1 peptidase M56	-	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	Peptidase_M56
CMS2_k127_69641_4	1408473.JHXO01000004_gene130	3.918e-12	74.0	COG1595@1|root,COG1595@2|Bacteria,4NF93@976|Bacteroidetes,2FNJV@200643|Bacteroidia	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS2_k127_69641_0	593750.Metfor_1690	8.797e-50	184.0	COG0703@1|root,arCOG01047@2157|Archaea,2Y4C3@28890|Euryarchaeota,2NB05@224756|Methanomicrobia	224756|Methanomicrobia	E	Shikimate kinase	-	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
CMS2_k127_69641_2	690850.Desaf_2645	2.1e-26	113.0	298TN@1|root,2ZVXW@2|Bacteria,1P5V0@1224|Proteobacteria,433RB@68525|delta/epsilon subdivisions	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_69641_3	290397.Adeh_1678	3.797e-17	88.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42V72@68525|delta/epsilon subdivisions,2WRHE@28221|Deltaproteobacteria,2Z1JS@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_697286_3	765952.PUV_00220	1.177e-06	61.0	COG4972@1|root,COG4972@2|Bacteria,2JFIK@204428|Chlamydiae	204428|Chlamydiae	NU	Pilus assembly protein	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
CMS2_k127_697286_0	521674.Plim_3639	6.548e-37	156.0	COG3156@1|root,COG3156@2|Bacteria,2IXHV@203682|Planctomycetes	203682|Planctomycetes	U	Type II secretion system (T2SS), protein K	-	-	-	-	-	-	-	-	-	-	-	-	T2SSK
CMS2_k127_697286_2	674977.VMC_02780	2.868e-09	68.0	COG4795@1|root,COG4795@2|Bacteria,1RJAE@1224|Proteobacteria,1S5ZZ@1236|Gammaproteobacteria,1XU01@135623|Vibrionales	135623|Vibrionales	U	general secretion pathway protein	epsJ	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
CMS2_k127_697286_1	883126.HMPREF9710_03904	3.06e-32	129.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR66@28216|Betaproteobacteria	28216|Betaproteobacteria	U	general secretion pathway protein G	gspG2	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
CMS2_k127_6988598_9	340099.Teth39_0329	0.0003443	44.0	COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,42F6G@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
CMS2_k127_6988598_7	1121448.DGI_0807	1.386e-09	70.0	COG2755@1|root,COG2755@2|Bacteria,1R1JV@1224|Proteobacteria	1224|Proteobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6988598_5	1194165.CAJF01000020_gene2934	9.471e-32	145.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
CMS2_k127_6988598_3	313628.LNTAR_17648	7.143e-76	274.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6988598_4	502025.Hoch_2959	1.007e-72	256.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,4313Z@68525|delta/epsilon subdivisions,2WX2K@28221|Deltaproteobacteria,2Z2QP@29|Myxococcales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
CMS2_k127_6988598_0	886293.Sinac_0285	0.0	1241.0	COG0745@1|root,COG0784@1|root,COG2203@1|root,COG5002@1|root,COG5278@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,COG5278@2|Bacteria,2IXNT@203682|Planctomycetes	203682|Planctomycetes	T	CHASE3 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,Response_reg
CMS2_k127_6988598_1	1210884.HG799463_gene9351	2.331e-141	454.0	COG1352@1|root,COG1352@2|Bacteria,2IXV1@203682|Planctomycetes	203682|Planctomycetes	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
CMS2_k127_6988598_6	990285.RGCCGE502_17770	9.105e-12	70.0	COG2201@1|root,COG2201@2|Bacteria,1RCWE@1224|Proteobacteria,2TRCY@28211|Alphaproteobacteria,4BEKS@82115|Rhizobiaceae	28211|Alphaproteobacteria	NT	CheB methylesterase	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest
CMS2_k127_6988598_2	886293.Sinac_0282	1.029e-78	285.0	COG0642@1|root,COG0784@1|root,COG3437@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,2IXG1@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
CMS2_k127_6988598_8	1122239.AULS01000008_gene2431	7.399e-08	59.0	COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria	2|Bacteria	L	Transposase	tnp3514a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve
CMS2_k127_6992230_0	96561.Dole_2882	2.483e-180	570.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,42M0Z@68525|delta/epsilon subdivisions,2WK36@28221|Deltaproteobacteria,2MJ5F@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Bile acid sodium symporter	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
CMS2_k127_6992230_8	34007.IT40_04180	1.594e-07	60.0	COG1396@1|root,COG1396@2|Bacteria,1MVQY@1224|Proteobacteria,2U070@28211|Alphaproteobacteria,2PUWA@265|Paracoccus	28211|Alphaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
CMS2_k127_6992230_4	56107.Cylst_5225	2.441e-60	219.0	29WGE@1|root,30I2I@2|Bacteria,1GFWI@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_6992230_3	269797.Mbar_A1995	4.695e-62	228.0	arCOG02516@1|root,arCOG02538@1|root,arCOG02516@2157|Archaea,arCOG02538@2157|Archaea,2Y7RK@28890|Euryarchaeota,2NBKX@224756|Methanomicrobia	2157|Archaea	S	Leucine rich repeats (6 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,He_PIG,PKD,PQQ_3,Peptidase_S8,S-layer
CMS2_k127_6992230_5	794903.OPIT5_26330	1.404e-41	164.0	COG2165@1|root,COG2165@2|Bacteria,46W6U@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS2_k127_6992230_2	525904.Tter_0019	2.696e-66	232.0	COG2102@1|root,COG2102@2|Bacteria,2NR1T@2323|unclassified Bacteria	2|Bacteria	S	Diphthamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
CMS2_k127_6992230_1	402777.KB235904_gene4630	1.855e-144	482.0	COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,1H97S@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS2_k127_6992230_6	1380394.JADL01000021_gene1868	4.965e-26	117.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,2JSB6@204441|Rhodospirillales	204441|Rhodospirillales	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
CMS2_k127_6992230_7	309801.trd_0547	1.055e-08	57.0	COG2096@1|root,COG2096@2|Bacteria,2G6TB@200795|Chloroflexi,27Y88@189775|Thermomicrobia	189775|Thermomicrobia	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
CMS2_k127_6992697_2	1121904.ARBP01000001_gene5577	3.557e-68	242.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos,Pur_ac_phosph_N
CMS2_k127_6992697_1	1121904.ARBP01000001_gene5577	1.422e-74	267.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos,Pur_ac_phosph_N
CMS2_k127_6992697_0	518766.Rmar_0491	8.061e-150	486.0	COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,1FJX9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS2_k127_701213_3	313628.LNTAR_12671	1.506e-121	406.0	COG2217@1|root,COG2217@2|Bacteria	2|Bacteria	P	Heavy metal translocating P-type atpase	cadA	-	3.6.3.3,3.6.3.5,3.6.3.54	ko:K01534,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5,3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
CMS2_k127_701213_12	1142394.PSMK_15630	1.821e-20	105.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	ko:K04088,ko:K14393	-	M00742	-	-	ko00000,ko00002,ko01000,ko02000	2.A.21.7	-	-	Band_7,SSF
CMS2_k127_701213_11	158190.SpiGrapes_2806	1.233e-37	153.0	COG0330@1|root,COG0330@2|Bacteria,2J5TU@203691|Spirochaetes	2|Bacteria	O	HflC and HflK could regulate a protease	hflC2	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
CMS2_k127_701213_5	1142394.PSMK_15610	8.824e-67	252.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS2_k127_701213_9	1142394.PSMK_15560	2.566e-44	173.0	COG1277@1|root,COG1277@2|Bacteria,2IYX5@203682|Planctomycetes	203682|Planctomycetes	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
CMS2_k127_701213_10	289376.THEYE_A1043	3.901e-43	166.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	argH	GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,4.3.2.1	ko:K00619,ko:K14681	ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230	M00028,M00029,M00844	R00259,R01086	RC00004,RC00064,RC00445,RC00447	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0946	ASL_C2,Acetyltransf_1,Lyase_1
CMS2_k127_701213_6	886293.Sinac_6209	1.956e-46	173.0	COG0764@1|root,COG0764@2|Bacteria,2J09I@203682|Planctomycetes	203682|Planctomycetes	I	3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein)	-	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
CMS2_k127_701213_7	886293.Sinac_6210	3.145e-45	167.0	COG0236@1|root,COG0236@2|Bacteria,2J04I@203682|Planctomycetes	203682|Planctomycetes	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
CMS2_k127_701213_8	886293.Sinac_6211	7.454e-45	169.0	COG0764@1|root,COG0764@2|Bacteria,2IZWX@203682|Planctomycetes	203682|Planctomycetes	I	3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein)	-	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
CMS2_k127_701213_4	1142394.PSMK_03130	2.442e-93	326.0	COG0304@1|root,COG0304@2|Bacteria,2IY1N@203682|Planctomycetes	203682|Planctomycetes	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS2_k127_701213_2	756272.Plabr_2931	4.58e-139	454.0	COG0304@1|root,COG0304@2|Bacteria,2IX8X@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS2_k127_701213_1	562970.Btus_0496	3.727e-139	454.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,4H9Y4@91061|Bacilli,278X3@186823|Alicyclobacillaceae	91061|Bacilli	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
CMS2_k127_701213_0	1142394.PSMK_14030	6.718e-145	499.0	COG1450@1|root,COG1450@2|Bacteria,2IX4B@203682|Planctomycetes	203682|Planctomycetes	NU	general secretion pathway protein D	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
CMS2_k127_7049497_16	1142394.PSMK_03080	1.163e-05	54.0	COG4967@1|root,COG4967@2|Bacteria	2|Bacteria	NU	type IV pilus modification protein PilV	ppdC	-	-	ko:K02458,ko:K02671,ko:K02681	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15	-	-	N_methyl,T2SSppdC
CMS2_k127_7049497_4	1142394.PSMK_25970	1.694e-110	369.0	COG1459@1|root,COG1459@2|Bacteria,2IYHA@203682|Planctomycetes	203682|Planctomycetes	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
CMS2_k127_7049497_2	1142394.PSMK_25980	3.47e-140	454.0	COG2805@1|root,COG2805@2|Bacteria,2IXRP@203682|Planctomycetes	203682|Planctomycetes	NU	COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS2_k127_7049497_1	521674.Plim_0426	4.431e-156	513.0	COG2804@1|root,COG2804@2|Bacteria,2IX4I@203682|Planctomycetes	203682|Planctomycetes	NU	COG2804 Type II secretory pathway ATPase PulE Tfp pilus assembly pathway ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
CMS2_k127_7049497_14	1123373.ATXI01000004_gene1487	2.961e-09	66.0	COG3167@1|root,COG3167@2|Bacteria,2GGSX@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	NU	Pilus assembly protein, PilO	-	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
CMS2_k127_7049497_15	1536775.H70737_28045	1.876e-07	62.0	COG4972@1|root,COG4972@2|Bacteria,1TSTG@1239|Firmicutes,4HMAG@91061|Bacilli,26S2S@186822|Paenibacillaceae	91061|Bacilli	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
CMS2_k127_7049497_5	886293.Sinac_2703	3.946e-89	307.0	COG0240@1|root,COG0240@2|Bacteria,2IWWN@203682|Planctomycetes	203682|Planctomycetes	I	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
CMS2_k127_7049497_6	926560.KE387023_gene2721	1.058e-84	296.0	COG0232@1|root,COG0232@2|Bacteria,1WI39@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Belongs to the dGTPase family. Type 2 subfamily	-	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
CMS2_k127_7049497_9	272844.PAB2301	2.429e-48	178.0	COG0537@1|root,arCOG00419@2157|Archaea,2XWGT@28890|Euryarchaeota,242M1@183968|Thermococci	183968|Thermococci	F	Hit family	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
CMS2_k127_7049497_17	575540.Isop_1811	0.0008427	51.0	2DP89@1|root,330ZJ@2|Bacteria,2J0PU@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_7049497_0	1191523.MROS_0240	3.051e-242	759.0	COG0129@1|root,COG0129@2|Bacteria	2|Bacteria	EG	dihydroxy-acid dehydratase activity	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.9	ko:K01687,ko:K16786	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010	M00019,M00570,M00582	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	iAF987.Gmet_1259,iECIAI39_1322.ECIAI39_3015	ILVD_EDD
CMS2_k127_7049497_13	65393.PCC7424_2919	2.542e-13	81.0	COG1708@1|root,COG1708@2|Bacteria,1GNYH@1117|Cyanobacteria,3KKBK@43988|Cyanothece	1117|Cyanobacteria	L	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_7049497_10	886293.Sinac_3714	6.845e-35	138.0	COG0727@1|root,COG0727@2|Bacteria,2IZM1@203682|Planctomycetes	203682|Planctomycetes	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
CMS2_k127_7049497_11	756272.Plabr_4536	1.584e-19	98.0	COG0727@1|root,COG0727@2|Bacteria,2J0KU@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_7049497_7	247490.KSU1_D0697	9.498e-66	236.0	COG1181@1|root,COG1181@2|Bacteria,2IZHT@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
CMS2_k127_7049497_8	537007.BLAHAN_06388	5.707e-59	217.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,3XZDE@572511|Blautia	186801|Clostridia	M	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
CMS2_k127_7049497_3	247490.KSU1_D0698	6.343e-111	378.0	COG0773@1|root,COG0773@2|Bacteria,2IYEH@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS2_k127_7064673_2	545694.TREPR_2998	6.598e-56	208.0	COG0407@1|root,COG0407@2|Bacteria,2J8ZX@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
CMS2_k127_7064673_1	583355.Caka_0545	6.393e-78	273.0	COG0673@1|root,COG0673@2|Bacteria,46UTE@74201|Verrucomicrobia,3K8EQ@414999|Opitutae	414999|Opitutae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.99.28	ko:K00118	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS2_k127_7064673_0	583355.Caka_0544	1.472e-78	271.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
CMS2_k127_7064673_4	498211.CJA_3342	1.375e-49	192.0	COG0477@1|root,COG2814@2|Bacteria,1QWEI@1224|Proteobacteria,1T3J4@1236|Gammaproteobacteria,1FHWR@10|Cellvibrio	1236|Gammaproteobacteria	EGP	Nucleoside H+ symporter	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	Nuc_H_symport
CMS2_k127_7064673_3	1501230.ET33_30135	5.568e-55	203.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,4HAWW@91061|Bacilli,274ZG@186822|Paenibacillaceae	91061|Bacilli	EH	Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction	dat	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
CMS2_k127_7064673_6	756272.Plabr_4051	3.652e-19	91.0	COG0261@1|root,COG0261@2|Bacteria,2J0XA@203682|Planctomycetes	203682|Planctomycetes	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
CMS2_k127_7064673_5	452637.Oter_0819	3.93e-49	180.0	COG0574@1|root,COG0574@2|Bacteria,46XFR@74201|Verrucomicrobia,3K763@414999|Opitutae	414999|Opitutae	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
CMS2_k127_7079610_9	1313172.YM304_22880	8.668e-22	112.0	COG5184@1|root,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF11,RCC1,RCC1_2,fn3
CMS2_k127_7079610_1	697281.Mahau_2745	9.238e-100	331.0	COG2159@1|root,COG2159@2|Bacteria,1TRU0@1239|Firmicutes,248VZ@186801|Clostridia,42GGM@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM amidohydrolase 2	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
CMS2_k127_7079610_5	316274.Haur_4639	4.778e-47	174.0	COG0290@1|root,COG0290@2|Bacteria,2G6N2@200795|Chloroflexi,375HT@32061|Chloroflexia	32061|Chloroflexia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
CMS2_k127_7079610_0	1031288.AXAA01000002_gene1457	1.225e-227	723.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,36DPZ@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
CMS2_k127_7079610_11	1142394.PSMK_13460	8.969e-15	81.0	COG1716@1|root,COG1716@2|Bacteria,2J0SY@203682|Planctomycetes	203682|Planctomycetes	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
CMS2_k127_7079610_2	886293.Sinac_5248	5.539e-90	317.0	COG2804@1|root,COG2804@2|Bacteria,2IXVD@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE
CMS2_k127_7079610_10	690850.Desaf_1097	5.963e-15	89.0	COG5434@1|root,COG5434@2|Bacteria,1R1I5@1224|Proteobacteria,4320W@68525|delta/epsilon subdivisions,2WWIY@28221|Deltaproteobacteria	690850.Desaf_1097|-	M	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_7079610_8	1379698.RBG1_1C00001G0194	5.5e-25	122.0	COG3211@1|root,COG3540@1|root,COG3211@2|Bacteria,COG3540@2|Bacteria,2NS16@2323|unclassified Bacteria	2|Bacteria	P	PhoD-like phosphatase	phoX	-	3.1.3.1	ko:K01113,ko:K07093	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF839
CMS2_k127_7079610_4	1499967.BAYZ01000057_gene4700	1.177e-53	207.0	COG1541@1|root,COG1541@2|Bacteria,2NR9N@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
CMS2_k127_7079610_6	443143.GM18_3917	1.155e-39	166.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,43RYC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS2_k127_7079610_7	335543.Sfum_2311	2.083e-34	136.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,42VTR@68525|delta/epsilon subdivisions,2X5PP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	PFAM Class I peptide chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
CMS2_k127_7079610_12	1123508.JH636450_gene7071	1.123e-11	76.0	COG2165@1|root,COG2165@2|Bacteria,2IYZU@203682|Planctomycetes	203682|Planctomycetes	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_7079610_3	452637.Oter_3025	3.101e-54	213.0	COG0684@1|root,COG0684@2|Bacteria,46VAD@74201|Verrucomicrobia,3K8HM@414999|Opitutae	414999|Opitutae	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
CMS2_k127_708802_1	706587.Desti_2318	5.841e-28	121.0	COG1595@1|root,COG1595@2|Bacteria,1N413@1224|Proteobacteria,42SGS@68525|delta/epsilon subdivisions,2WPQ9@28221|Deltaproteobacteria,2MQN3@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_708802_2	1123242.JH636434_gene5358	1.229e-14	83.0	COG2165@1|root,COG2165@2|Bacteria,2IWSH@203682|Planctomycetes	203682|Planctomycetes	NU	best DB hits PFAM PF00114	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_708802_3	1303518.CCALI_00933	9.14e-13	78.0	COG4537@1|root,COG4537@2|Bacteria	2|Bacteria	U	Required for transformation and DNA binding	comGC	GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944	-	ko:K02245,ko:K02456	ko03070,ko05111,map03070,map05111	M00331,M00429	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS2_k127_708802_0	335543.Sfum_1838	6.651e-281	879.0	COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,42M9U@68525|delta/epsilon subdivisions,2WJ4X@28221|Deltaproteobacteria,2MQ64@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Tex-like protein N-terminal domain	tex	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
CMS2_k127_708952_16	234267.Acid_5440	6.242e-39	155.0	COG4784@1|root,COG4784@2|Bacteria	2|Bacteria	S	Peptidase m48 ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CMS2_k127_708952_12	459349.CLOAM0193	4.111e-67	259.0	COG4886@1|root,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	COR,LRR_4,LRR_6,LRR_8,Roc
CMS2_k127_708952_27	1144275.COCOR_07265	6.467e-11	76.0	COG2374@1|root,COG2374@2|Bacteria,1QXVK@1224|Proteobacteria	1224|Proteobacteria	S	Endonuclease Exonuclease Phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Exo_endo_phos,LTD
CMS2_k127_708952_13	926550.CLDAP_19500	2.968e-58	231.0	COG0584@1|root,COG0823@1|root,COG3210@1|root,COG4886@1|root,COG0584@2|Bacteria,COG0823@2|Bacteria,COG3210@2|Bacteria,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	3.1.4.46	ko:K01126,ko:K21449	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000,ko02000	1.B.40.2	-	-	GDPD_2
CMS2_k127_708952_6	204669.Acid345_2310	3.913e-113	408.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria,2JMN2@204432|Acidobacteriia	204432|Acidobacteriia	T	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
CMS2_k127_708952_0	1167006.UWK_01801	1.51e-217	695.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2MKAY@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Asparagine synthase, glutamine-hydrolyzing	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS2_k127_708952_3	497964.CfE428DRAFT_1943	7.118e-121	397.0	COG2133@1|root,COG2133@2|Bacteria,46THQ@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS2_k127_708952_4	1123242.JH636435_gene2208	1.156e-116	386.0	COG4299@1|root,COG4299@2|Bacteria,2J1X5@203682|Planctomycetes	203682|Planctomycetes	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_708952_33	215803.DB30_7211	8.926e-06	51.0	2EFSR@1|root,339IR@2|Bacteria,1QASU@1224|Proteobacteria,435A1@68525|delta/epsilon subdivisions,2WZM4@28221|Deltaproteobacteria,2Z2CW@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
CMS2_k127_708952_14	522306.CAP2UW1_0277	6.971e-55	201.0	2CCB6@1|root,32YGR@2|Bacteria,1NC64@1224|Proteobacteria,2VWKT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
CMS2_k127_708952_11	880073.Calab_1912	5.768e-71	250.0	COG2518@1|root,COG2518@2|Bacteria,2NP7E@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CMS2_k127_708952_15	1121406.JAEX01000002_gene1175	9.683e-41	162.0	COG1597@1|root,COG1597@2|Bacteria	2|Bacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
CMS2_k127_708952_22	497964.CfE428DRAFT_5014	7.19e-27	130.0	COG2304@1|root,COG3055@1|root,COG3119@1|root,COG3291@1|root,COG2304@2|Bacteria,COG3055@2|Bacteria,COG3119@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	rapB1	-	3.2.1.4	ko:K01179,ko:K07004,ko:K12548	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Laminin_G_3
CMS2_k127_708952_32	1144313.PMI10_03156	5.956e-06	61.0	COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,1I0G9@117743|Flavobacteriia,2NTFA@237|Flavobacterium	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_708952_18	626887.J057_22875	2.958e-32	147.0	COG2133@1|root,COG3266@1|root,COG3299@1|root,COG2133@2|Bacteria,COG3266@2|Bacteria,COG3299@2|Bacteria,1QZBF@1224|Proteobacteria,1T44G@1236|Gammaproteobacteria,4658Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	PA14	-	-	-	-	-	-	-	-	-	-	-	-	PA14,fn3
CMS2_k127_708952_30	886379.AEWI01000005_gene994	4.982e-08	67.0	COG3693@1|root,COG3693@2|Bacteria,4NE1E@976|Bacteroidetes,2FNP0@200643|Bacteroidia,3XJX8@558415|Marinilabiliaceae	976|Bacteroidetes	G	Glycosyl hydrolase family 10	xynA	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	CBM_4_9,Glyco_hydro_10
CMS2_k127_708952_25	1122609.AUGT01000008_gene2868	5.791e-15	90.0	COG0366@1|root,COG0515@1|root,COG2133@1|root,COG3227@1|root,COG4733@1|root,COG0366@2|Bacteria,COG0515@2|Bacteria,COG2133@2|Bacteria,COG3227@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.3	ko:K01178,ko:K14645,ko:K18546	ko00500,ko01100,ko02024,map00500,map01100,map02024	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH15	-	Alpha-amylase,GSDH,He_PIG,PKD,Pro_Al_protease,SLH,Trypsin,fn3
CMS2_k127_708952_23	794903.OPIT5_04875	2.247e-25	124.0	COG2133@1|root,COG3266@1|root,COG4932@1|root,COG5184@1|root,COG2133@2|Bacteria,COG3266@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,46Z90@74201|Verrucomicrobia,3K9IV@414999|Opitutae	414999|Opitutae	M	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	PA14
CMS2_k127_708952_9	118173.KB235914_gene3829	1.326e-79	287.0	2DBP2@1|root,2ZA71@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_708952_21	1121382.JQKG01000063_gene3041	3.971e-27	120.0	COG3507@1|root,COG4733@1|root,COG3507@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	pagaT	-	3.2.1.80	ko:K03332	ko00051,map00051	-	R00879	-	ko00000,ko00001,ko01000	-	-	-	F5_F8_type_C,Glyco_hydro_43,RicinB_lectin_2
CMS2_k127_708952_10	158190.SpiGrapes_2270	2.192e-72	256.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
CMS2_k127_708952_20	1122986.KB908329_gene2419	7.909e-28	131.0	COG5652@1|root,COG5652@2|Bacteria,4NIE7@976|Bacteroidetes,2FQJV@200643|Bacteroidia	976|Bacteroidetes	S	Heparinase II/III-like protein	-	GO:0003674,GO:0003824,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006082,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008201,GO:0009056,GO:0009057,GO:0009987,GO:0016829,GO:0016835,GO:0016837,GO:0030202,GO:0030203,GO:0030211,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044464,GO:0047488,GO:0071704,GO:0097367,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1901681,GO:1903510	4.2.2.7,4.2.2.8	ko:K19051	-	-	-	-	ko00000,ko01000	-	PL21	-	DUF4962,Hepar_II_III
CMS2_k127_708952_19	497964.CfE428DRAFT_6023	3.94e-28	131.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_708952_17	240016.ABIZ01000001_gene427	3.229e-35	154.0	COG1680@1|root,COG1680@2|Bacteria,46TM4@74201|Verrucomicrobia	74201|Verrucomicrobia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_708952_29	66875.JODY01000030_gene3997	1.795e-08	68.0	COG0388@1|root,COG2173@1|root,COG0388@2|Bacteria,COG2173@2|Bacteria,2HZRJ@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	ddpX	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	CN_hydrolase,Peptidase_M15
CMS2_k127_708952_31	1206732.BAGD01000081_gene3471	4.494e-06	60.0	COG0388@1|root,COG0388@2|Bacteria,2I340@201174|Actinobacteria,4G71R@85025|Nocardiaceae	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
CMS2_k127_708952_5	1340493.JNIF01000004_gene17	9.951e-114	407.0	COG1680@1|root,COG1680@2|Bacteria,3Y8A8@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS2_k127_708952_2	344747.PM8797T_03059	8.354e-147	507.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase,Beta_helix,Glyco_hydro_28,Pectate_lyase_3
CMS2_k127_708952_1	344747.PM8797T_32040	6.845e-154	526.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Malectin,PQQ_2,PQQ_3
CMS2_k127_708952_8	401053.AciPR4_2248	2.042e-80	287.0	COG1874@1|root,COG1874@2|Bacteria,3Y6EF@57723|Acidobacteria,2JKVE@204432|Acidobacteriia	204432|Acidobacteriia	G	Domain of unknown function (DUF4832)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4832
CMS2_k127_708952_24	344747.PM8797T_09134	3.463e-25	109.0	COG1695@1|root,COG1695@2|Bacteria,2J1J6@203682|Planctomycetes	203682|Planctomycetes	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
CMS2_k127_708952_26	1142394.PSMK_07570	7.696e-14	85.0	2A5PN@1|root,30UEH@2|Bacteria,2J3F8@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_708952_34	1463820.JOGW01000008_gene1740	9.573e-05	49.0	COG1621@1|root,COG1621@2|Bacteria,2H474@201174|Actinobacteria	201174|Actinobacteria	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	TAT_signal
CMS2_k127_708952_7	1410653.JHVC01000018_gene2285	1.825e-97	349.0	COG1404@1|root,COG1404@2|Bacteria,1VD5C@1239|Firmicutes,24C2E@186801|Clostridia,36H8D@31979|Clostridiaceae	186801|Clostridia	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS2_k127_713224_2	1396418.BATQ01000186_gene2161	6.054e-70	247.0	COG3401@1|root,COG3401@2|Bacteria	2|Bacteria	Q	FG-GAP repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS2_k127_713224_1	1122918.KB907280_gene254	2.893e-85	304.0	COG3934@1|root,COG3934@2|Bacteria,1VUFZ@1239|Firmicutes	1239|Firmicutes	G	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5060
CMS2_k127_713224_4	1298865.H978DRAFT_2627	9.234e-34	140.0	COG3713@1|root,COG3713@2|Bacteria,1QQSA@1224|Proteobacteria,1RTFB@1236|Gammaproteobacteria,466YH@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	MltA-interacting protein MipA	-	-	-	ko:K07274	-	-	-	-	ko00000,ko02000	9.B.99.1	-	-	MipA
CMS2_k127_713224_5	525898.Sdel_2255	1.262e-27	116.0	COG2105@1|root,COG2105@2|Bacteria,1NEI1@1224|Proteobacteria,431WP@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Gamma-glutamyl cyclotransferase, AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
CMS2_k127_713224_0	765910.MARPU_08020	3.933e-112	374.0	COG4313@1|root,COG4313@2|Bacteria,1ND6Y@1224|Proteobacteria,1RYD3@1236|Gammaproteobacteria,1WW33@135613|Chromatiales	135613|Chromatiales	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
CMS2_k127_713224_6	1114959.SZMC14600_08268	1.059e-15	90.0	COG3209@1|root,COG3250@1|root,COG3534@1|root,COG3209@2|Bacteria,COG3250@2|Bacteria,COG3534@2|Bacteria,2I35N@201174|Actinobacteria,4EDQ6@85010|Pseudonocardiales	201174|Actinobacteria	GKLMT	LamG-like jellyroll fold domain	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS2_k127_713224_3	1123508.JH636439_gene795	1.391e-57	218.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	Lipase_GDSL_2
CMS2_k127_713224_7	575540.Isop_1337	8.318e-09	59.0	COG1560@1|root,COG1560@2|Bacteria,2IY7N@203682|Planctomycetes	203682|Planctomycetes	M	Lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
CMS2_k127_716464_0	880073.Calab_1142	1.261e-229	717.0	COG1350@1|root,COG1350@2|Bacteria,2NNY3@2323|unclassified Bacteria	2|Bacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS2_k127_721285_1	1396141.BATP01000059_gene2593	5.306e-17	93.0	COG0515@1|root,COG0515@2|Bacteria,46U28@74201|Verrucomicrobia,2IWN1@203494|Verrucomicrobiae	74201|Verrucomicrobia	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF1648,DUF4019,Pkinase
CMS2_k127_721285_0	1267535.KB906767_gene447	5.839e-118	392.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria,2JMN2@204432|Acidobacteriia	204432|Acidobacteriia	T	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
CMS2_k127_721285_2	335283.Neut_1057	1.184e-15	81.0	COG0500@1|root,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,2VR1M@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
CMS2_k127_724298_1	909663.KI867150_gene2237	6.171e-200	634.0	COG0034@1|root,COG0034@2|Bacteria,1R7JX@1224|Proteobacteria,42MAC@68525|delta/epsilon subdivisions,2WKFD@28221|Deltaproteobacteria,2MQ6P@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Glutamine amidotransferase domain	-	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7
CMS2_k127_724298_6	1163408.UU9_10517	1.514e-46	180.0	COG1708@1|root,COG1708@2|Bacteria,1RCAH@1224|Proteobacteria,1S3KC@1236|Gammaproteobacteria,1X5GB@135614|Xanthomonadales	135614|Xanthomonadales	K	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2,NTP_transf_2
CMS2_k127_724298_0	880073.Calab_3264	1.699e-275	868.0	COG0363@1|root,COG0363@2|Bacteria	2|Bacteria	G	glucosamine-6-phosphate deaminase activity	nagB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	3.1.1.31,3.5.99.6	ko:K01057,ko:K02564	ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso,PIG-L
CMS2_k127_724298_8	1121468.AUBR01000020_gene2852	2.682e-33	149.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,42EX6@68295|Thermoanaerobacterales	186801|Clostridia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS2_k127_724298_4	1157635.KB892008_gene3604	2.014e-63	236.0	COG1635@1|root,COG1635@2|Bacteria	2|Bacteria	H	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur	thi4	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0018131,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0046872,GO:0046914,GO:0052837,GO:0052838,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	ko:K03146	ko00730,ko01100,map00730,map01100	-	R10685	RC00033,RC03253,RC03254	ko00000,ko00001	-	-	-	FAD_oxidored,Thi4
CMS2_k127_724298_9	1170562.Cal6303_1216	8.15e-28	114.0	COG2442@1|root,COG2442@2|Bacteria,1G87F@1117|Cyanobacteria,1HPFU@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
CMS2_k127_724298_2	1254432.SCE1572_51570	5.35e-99	336.0	COG3568@1|root,COG3568@2|Bacteria,1PPNP@1224|Proteobacteria,42QW2@68525|delta/epsilon subdivisions,2WMRN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS2_k127_724298_3	1121918.ARWE01000001_gene460	1.913e-80	280.0	COG1606@1|root,COG1606@2|Bacteria,1R7UZ@1224|Proteobacteria,42Q6V@68525|delta/epsilon subdivisions,2WKIM@28221|Deltaproteobacteria,43UAA@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM asparagine synthase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase,QueC
CMS2_k127_724298_10	388467.A19Y_2214	1.992e-24	109.0	28JE3@1|root,2Z98B@2|Bacteria,1G13G@1117|Cyanobacteria,1H9TN@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_724298_13	1499967.BAYZ01000193_gene3903	2.505e-14	78.0	2DMC5@1|root,32IWK@2|Bacteria,2NREU@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_724298_12	1499967.BAYZ01000193_gene3903	9.272e-21	104.0	2DMC5@1|root,32IWK@2|Bacteria,2NREU@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_724298_5	671143.DAMO_2514	4.069e-53	192.0	COG4914@1|root,COG4914@2|Bacteria,2NR4D@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204
CMS2_k127_724298_11	314278.NB231_05936	6.631e-21	104.0	291NB@1|root,2ZP8I@2|Bacteria,1P5ZB@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
CMS2_k127_724298_7	1131814.JAFO01000001_gene2573	1.262e-45	167.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	5.3.3.19	ko:K19547	ko01130,map01130	M00787	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupin_2,HATPase_c,His_kinase,PocR
CMS2_k127_733355_0	264732.Moth_0136	6.807e-107	358.0	COG1415@1|root,COG1415@2|Bacteria,1UWH7@1239|Firmicutes,24DPJ@186801|Clostridia,42EWV@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
CMS2_k127_733355_1	575540.Isop_0876	7.955e-58	216.0	COG2931@1|root,COG2931@2|Bacteria,2J1K0@203682|Planctomycetes	203682|Planctomycetes	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_733355_3	1185876.BN8_03398	6.461e-18	96.0	COG2133@1|root,COG2133@2|Bacteria,4NIJA@976|Bacteroidetes,47NB2@768503|Cytophagia	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,GSDH,Ig_3,PA14
CMS2_k127_733355_2	661478.OP10G_4315	1.026e-53	205.0	COG4124@1|root,COG4124@2|Bacteria	661478.OP10G_4315|-	G	Belongs to the glycosyl hydrolase 26 family	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	-
CMS2_k127_741221_5	452637.Oter_4175	1.136e-30	124.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,46VB0@74201|Verrucomicrobia,3K8AK@414999|Opitutae	414999|Opitutae	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS2_k127_741221_4	886293.Sinac_4026	6.764e-56	201.0	COG1595@1|root,COG1595@2|Bacteria,2IZ8A@203682|Planctomycetes	203682|Planctomycetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS2_k127_741221_1	247490.KSU1_D0623	2.303e-146	470.0	COG0059@1|root,COG0059@2|Bacteria,2IXH2@203682|Planctomycetes	203682|Planctomycetes	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
CMS2_k127_741221_0	880070.Cycma_0165	2.531e-157	511.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40
CMS2_k127_741221_6	1041159.AZUW01000040_gene2659	7.188e-29	119.0	COG4804@1|root,COG4804@2|Bacteria,1NBWK@1224|Proteobacteria,2TV70@28211|Alphaproteobacteria,4BI5K@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1016)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1016
CMS2_k127_741221_3	1403819.BATR01000020_gene698	9.505e-123	432.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,46UAE@74201|Verrucomicrobia,2IV44@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_12,WD40
CMS2_k127_741221_2	1250232.JQNJ01000001_gene2712	8.449e-142	462.0	COG3940@1|root,COG3940@2|Bacteria,4NKZU@976|Bacteroidetes,1I0QH@117743|Flavobacteriia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
CMS2_k127_748876_7	1434325.AZQN01000010_gene3965	1.781e-12	81.0	COG1228@1|root,COG4946@1|root,COG1228@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
CMS2_k127_748876_5	314230.DSM3645_20022	1.533e-65	234.0	COG0106@1|root,COG0106@2|Bacteria,2IYYG@203682|Planctomycetes	203682|Planctomycetes	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CMS2_k127_748876_3	926569.ANT_30710	6.241e-89	305.0	COG1957@1|root,COG1957@2|Bacteria,2G7IF@200795|Chloroflexi	200795|Chloroflexi	F	PFAM Inosine uridine-preferring nucleoside hydrolase	-	-	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
CMS2_k127_748876_4	1158294.JOMI01000007_gene298	1.622e-85	293.0	COG0524@1|root,COG0524@2|Bacteria,4NENQ@976|Bacteroidetes,2FPM3@200643|Bacteroidia	976|Bacteroidetes	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CMS2_k127_748876_1	287.DR97_5902	4.581e-105	351.0	COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,1S0BQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	ABC-type sugar transport system periplasmic component	rbsB	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
CMS2_k127_748876_0	626418.bglu_1g18670	2.356e-168	546.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2VPAV@28216|Betaproteobacteria,1K04W@119060|Burkholderiaceae	28216|Betaproteobacteria	G	ABC transporter	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
CMS2_k127_748876_2	1123487.KB892834_gene3009	2.885e-102	344.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2WH7G@28216|Betaproteobacteria,2KZQT@206389|Rhodocyclales	28216|Betaproteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
CMS2_k127_748876_8	1229780.BN381_40083	2.704e-07	62.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,3UWWH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	T	Forkhead associated domain	garA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006110,GO:0006140,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010563,GO:0010675,GO:0010677,GO:0016020,GO:0016310,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0030312,GO:0030808,GO:0030809,GO:0030811,GO:0030812,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0036211,GO:0042325,GO:0042326,GO:0042802,GO:0043170,GO:0043412,GO:0043457,GO:0043467,GO:0043470,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045820,GO:0045912,GO:0045934,GO:0045936,GO:0045980,GO:0046777,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051193,GO:0051195,GO:0051196,GO:0051198,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901564,GO:1903578,GO:1903579,GO:2001169,GO:2001170	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
CMS2_k127_748876_6	1047013.AQSP01000125_gene2637	7.647e-64	235.0	COG0823@1|root,COG4946@1|root,COG0823@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Amidohydro_1,PD40,PG_binding_1,Pkinase,TolB_N
CMS2_k127_760326_10	660470.Theba_1436	1.215e-14	76.0	COG1899@1|root,COG1899@2|Bacteria,2GDSY@200918|Thermotogae	200918|Thermotogae	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_760326_0	761193.Runsl_0035	6.255e-234	739.0	COG0546@1|root,COG2870@1|root,COG0546@2|Bacteria,COG2870@2|Bacteria,4NJ8F@976|Bacteroidetes,47MRA@768503|Cytophagia	976|Bacteroidetes	M	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase,PfkB
CMS2_k127_760326_12	311424.DhcVS_787	3.266e-05	51.0	COG2047@1|root,COG2047@2|Bacteria,2GAMQ@200795|Chloroflexi,34CSY@301297|Dehalococcoidia	301297|Dehalococcoidia	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
CMS2_k127_760326_11	1071085.KK033114_gene1319	2.251e-09	59.0	COG2312@1|root,arCOG08208@2157|Archaea,2Y0MM@28890|Euryarchaeota,23Y4M@183963|Halobacteria	183963|Halobacteria	S	Erythromycin esterase	-	-	-	ko:K06880	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Erythro_esteras
CMS2_k127_760326_6	575540.Isop_2996	1.807e-38	147.0	COG0335@1|root,COG0335@2|Bacteria,2IZVX@203682|Planctomycetes	203682|Planctomycetes	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
CMS2_k127_760326_9	1121468.AUBR01000050_gene2031	7.832e-19	91.0	COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,42H26@68295|Thermoanaerobacterales	186801|Clostridia	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
CMS2_k127_760326_3	562970.Btus_0052	8.06e-68	239.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli,27859@186823|Alicyclobacillaceae	91061|Bacilli	L	TatD related DNase	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
CMS2_k127_760326_2	237368.SCABRO_03771	7.735e-90	318.0	COG0358@1|root,COG0358@2|Bacteria,2IXQ4@203682|Planctomycetes	203682|Planctomycetes	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
CMS2_k127_760326_1	886293.Sinac_1564	8.033e-186	599.0	COG0568@1|root,COG0568@2|Bacteria,2IXI3@203682|Planctomycetes	203682|Planctomycetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS2_k127_760326_5	1089544.KB912942_gene1882	1.652e-51	190.0	COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4DZTG@85010|Pseudonocardiales	201174|Actinobacteria	S	Phosphoribosyl transferase domain	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
CMS2_k127_760326_8	1121272.KB903290_gene4660	4.614e-22	101.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4DC71@85008|Micromonosporales	201174|Actinobacteria	S	Phosphoribosyl transferase domain	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
CMS2_k127_760326_4	886293.Sinac_5728	1.047e-52	198.0	COG2264@1|root,COG2264@2|Bacteria,2J3H0@203682|Planctomycetes	203682|Planctomycetes	J	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
CMS2_k127_760326_13	67281.JNZZ01000036_gene651	0.0002392	48.0	2BHP5@1|root,32BS6@2|Bacteria,2IS16@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3800
CMS2_k127_760326_7	402777.KB235904_gene3412	3.193e-25	121.0	COG0457@1|root,COG0457@2|Bacteria,1G36K@1117|Cyanobacteria,1H9PH@1150|Oscillatoriales	1117|Cyanobacteria	O	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
CMS2_k127_79100_1	756272.Plabr_2750	4.46e-125	424.0	COG0557@1|root,COG0557@2|Bacteria,2IX1J@203682|Planctomycetes	203682|Planctomycetes	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
CMS2_k127_79100_3	1235790.C805_00844	1.365e-19	100.0	2E2AR@1|root,32XG5@2|Bacteria,1VC42@1239|Firmicutes,25DRJ@186801|Clostridia	186801|Clostridia	S	AP2 domain	-	-	-	-	-	-	-	-	-	-	-	-	AP2,HNH_3
CMS2_k127_79100_0	1303518.CCALI_00619	1.781e-162	531.0	COG3693@1|root,COG3693@2|Bacteria	2|Bacteria	G	endo-1,4-beta-xylanase activity	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	CBM_4_9,Glyco_hydro_10
CMS2_k127_79100_2	247490.KSU1_C0390	3.496e-31	129.0	COG0162@1|root,COG0162@2|Bacteria,2IXZM@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
CMS2_k127_802404_13	1123242.JH636434_gene3756	1.313e-08	57.0	COG1352@1|root,COG2201@1|root,COG5002@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG5002@2|Bacteria,2IWSR@203682|Planctomycetes	203682|Planctomycetes	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10,PAS_4,PAS_9,Response_reg
CMS2_k127_802404_1	313624.NSP_4440	1.027e-212	670.0	COG0055@1|root,COG0055@2|Bacteria,1G1BK@1117|Cyanobacteria,1HIUK@1161|Nostocales	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	-	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
CMS2_k127_802404_8	767817.Desgi_4159	2.003e-36	142.0	COG0355@1|root,COG0355@2|Bacteria,1VHIW@1239|Firmicutes,24TSB@186801|Clostridia	186801|Clostridia	C	ATP synthase, Delta/Epsilon chain, beta-sandwich domain	-	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
CMS2_k127_802404_10	767817.Desgi_4158	2.723e-23	102.0	2CBNW@1|root,32RTR@2|Bacteria,1VIKC@1239|Firmicutes,24SHX@186801|Clostridia	186801|Clostridia	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
CMS2_k127_802404_12	69279.BG36_14125	2.066e-10	65.0	2E6XU@1|root,331H5@2|Bacteria	2|Bacteria	S	N-ATPase, AtpR subunit	-	-	-	-	-	-	-	-	-	-	-	-	AtpR
CMS2_k127_802404_4	313624.NSP_4400	3.944e-91	310.0	COG0356@1|root,COG0356@2|Bacteria,1G01X@1117|Cyanobacteria,1HJMJ@1161|Nostocales	2|Bacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB1	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
CMS2_k127_802404_9	1385935.N836_02705	4.624e-34	134.0	COG0636@1|root,COG0636@2|Bacteria,1G7XV@1117|Cyanobacteria,1HGFW@1150|Oscillatoriales	1117|Cyanobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
CMS2_k127_802404_7	247490.KSU1_C1026	4.039e-41	166.0	COG0711@1|root,COG0711@2|Bacteria,2IZ3I@203682|Planctomycetes	203682|Planctomycetes	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
CMS2_k127_802404_2	313624.NSP_4370	6.951e-206	656.0	COG0056@1|root,COG0056@2|Bacteria,1FZXK@1117|Cyanobacteria,1HJTE@1161|Nostocales	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA2	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
CMS2_k127_802404_5	247490.KSU1_C1028	8.838e-84	288.0	COG0224@1|root,COG0224@2|Bacteria,2IZ25@203682|Planctomycetes	203682|Planctomycetes	C	ATP synthase	-	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
CMS2_k127_802404_11	926560.KE387025_gene4049	5.917e-11	69.0	COG1796@1|root,COG1796@2|Bacteria	2|Bacteria	L	DNA-directed DNA polymerase activity	dpbF	-	3.1.11.5	ko:K02347,ko:K03581,ko:K04477	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,HHH_8
CMS2_k127_802404_6	1123253.AUBD01000005_gene84	2.617e-57	207.0	COG2095@1|root,COG2095@2|Bacteria,1N689@1224|Proteobacteria,1RPV0@1236|Gammaproteobacteria,1X4BK@135614|Xanthomonadales	135614|Xanthomonadales	U	UPF0056 membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	MarC
CMS2_k127_802404_0	688269.Theth_0442	4.946e-225	713.0	COG0058@1|root,COG0058@2|Bacteria,2GCCY@200918|Thermotogae	200918|Thermotogae	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
CMS2_k127_802404_3	886293.Sinac_6591	2.337e-121	405.0	COG3385@1|root,COG3385@2|Bacteria,2IZ65@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
CMS2_k127_821768_2	411479.BACUNI_00694	2.185e-196	621.0	COG1070@1|root,COG1070@2|Bacteria,4NFBZ@976|Bacteroidetes,2FPIS@200643|Bacteroidia,4AMYR@815|Bacteroidaceae	976|Bacteroidetes	G	Carbohydrate kinase, FGGY family protein	xylB_2	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
CMS2_k127_821768_1	314230.DSM3645_15535	1.134e-197	628.0	COG3119@1|root,COG3119@2|Bacteria,2IX47@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.10.1.1	ko:K01565	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078	R07814	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4976,Sulfatase
CMS2_k127_821768_5	1121859.KB890738_gene3329	4.285e-124	408.0	COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,47KQM@768503|Cytophagia	976|Bacteroidetes	G	Alpha-L-fucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Alpha_L_fucos
CMS2_k127_821768_4	641524.ADICYQ_3281	9.899e-139	456.0	COG3119@1|root,COG3119@2|Bacteria,4NEPB@976|Bacteroidetes	976|Bacteroidetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS2_k127_821768_0	1396141.BATP01000030_gene3773	0.0	1142.0	COG3250@1|root,COG3387@1|root,COG3250@2|Bacteria,COG3387@2|Bacteria	2|Bacteria	G	glucan 1,4-alpha-glucosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1793,DUF4964,DUF4965,DUF5127,RicinB_lectin_2
CMS2_k127_821768_3	762982.HMPREF9442_00965	7.596e-167	577.0	COG3250@1|root,COG4733@1|root,COG3250@2|Bacteria,COG4733@2|Bacteria,4NFPC@976|Bacteroidetes,2FPUZ@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,VCBS
CMS2_k127_821768_8	497964.CfE428DRAFT_0921	2.921e-61	218.0	COG4112@1|root,COG4112@2|Bacteria,46V3C@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_821768_6	448385.sce7444	2.041e-85	295.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42SWD@68525|delta/epsilon subdivisions,2WK1W@28221|Deltaproteobacteria,2YYDA@29|Myxococcales	28221|Deltaproteobacteria	K	Sir2 family	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
CMS2_k127_821768_10	67352.JODS01000001_gene92	7.749e-08	61.0	COG1595@1|root,COG1595@2|Bacteria,2GM3E@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
CMS2_k127_821768_11	983917.RGE_30520	8.182e-06	58.0	COG3712@1|root,COG3712@2|Bacteria,1QB18@1224|Proteobacteria,2VS2W@28216|Betaproteobacteria	28216|Betaproteobacteria	PT	Domain of unknown function (DUF4880)	-	-	-	ko:K07165	-	-	-	-	ko00000	-	-	-	DUF4880,FecR
CMS2_k127_821768_9	1278073.MYSTI_00123	5.182e-08	66.0	COG4932@1|root,COG4932@2|Bacteria,1PEGG@1224|Proteobacteria,43854@68525|delta/epsilon subdivisions,2X3F3@28221|Deltaproteobacteria,2YVTB@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS2_k127_846796_2	994573.T472_0218860	2.033e-155	509.0	COG3408@1|root,COG3408@2|Bacteria,1UNFF@1239|Firmicutes,25H1X@186801|Clostridia,36PH0@31979|Clostridiaceae	186801|Clostridia	G	Glycosyl hydrolase family 63 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
CMS2_k127_846796_4	477184.KYC_08765	1.957e-26	125.0	COG0491@1|root,COG0491@2|Bacteria,1MUT2@1224|Proteobacteria,2VJ0Y@28216|Betaproteobacteria,3T659@506|Alcaligenaceae	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_846796_5	1131814.JAFO01000001_gene4160	4.554e-24	117.0	COG0491@1|root,COG0491@2|Bacteria,1MUT2@1224|Proteobacteria,2TRG9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	MA20_14090	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS2_k127_846796_3	555088.DealDRAFT_0038	1.554e-82	285.0	COG1163@1|root,COG1163@2|Bacteria,1TSAP@1239|Firmicutes,24EEW@186801|Clostridia	186801|Clostridia	S	GTP-binding protein HSR1-related	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
CMS2_k127_846796_1	748449.Halha_1207	1.879e-171	562.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,3WA9E@53433|Halanaerobiales	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
CMS2_k127_846796_0	502025.Hoch_2274	7.845e-228	717.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2WWD4@28221|Deltaproteobacteria,2YTYG@29|Myxococcales	28221|Deltaproteobacteria	S	oligopeptide transporter, OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
CMS2_k127_896682_12	1349822.NSB1T_02690	5.207e-41	164.0	COG0615@1|root,COG2605@1|root,COG0615@2|Bacteria,COG2605@2|Bacteria,4NGSD@976|Bacteroidetes,2FQ1X@200643|Bacteroidia,22WKK@171551|Porphyromonadaceae	976|Bacteroidetes	IM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,GHMP_kinases_C
CMS2_k127_896682_4	1150626.PHAMO_270230	2.815e-129	423.0	COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,2TRF6@28211|Alphaproteobacteria,2JQJR@204441|Rhodospirillales	204441|Rhodospirillales	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
CMS2_k127_896682_6	1128421.JAGA01000003_gene3143	6.704e-67	254.0	COG3437@1|root,COG3437@2|Bacteria,2NP8B@2323|unclassified Bacteria	2|Bacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HD,HD_5,HisKA_7TM,Response_reg
CMS2_k127_896682_18	1283300.ATXB01000001_gene998	4.813e-08	66.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1XEK8@135618|Methylococcales	135618|Methylococcales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_896682_10	96561.Dole_1704	1.211e-46	193.0	COG3420@1|root,COG3420@2|Bacteria,1MZHI@1224|Proteobacteria,43BRC@68525|delta/epsilon subdivisions,2WUM4@28221|Deltaproteobacteria,2MN6K@213118|Desulfobacterales	1224|Proteobacteria	P	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_896682_17	278957.ABEA03000179_gene2880	3.324e-09	68.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_896682_13	1173023.KE650771_gene2602	1.112e-39	153.0	COG1063@1|root,COG1063@2|Bacteria,1G2NW@1117|Cyanobacteria	1117|Cyanobacteria	E	Alcohol dehydrogenase GroES-associated	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
CMS2_k127_896682_11	344747.PM8797T_04095	1.355e-43	165.0	COG1063@1|root,COG1063@2|Bacteria,2IXCG@203682|Planctomycetes	203682|Planctomycetes	C	COG1063 Threonine dehydrogenase and related Zn-dependent	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
CMS2_k127_896682_5	1123242.JH636435_gene1403	1.508e-80	286.0	COG1207@1|root,COG1207@2|Bacteria,2IXBV@203682|Planctomycetes	203682|Planctomycetes	M	Sugar nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_4
CMS2_k127_896682_16	880073.Calab_2522	2.943e-14	76.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CMS2_k127_896682_1	667014.Thein_0064	1.469e-151	492.0	COG0119@1|root,COG0119@2|Bacteria,2GHCY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like,dCache_1
CMS2_k127_896682_2	1121406.JAEX01000002_gene1126	8.622e-151	491.0	COG0500@1|root,COG1215@1|root,COG1215@2|Bacteria,COG2226@2|Bacteria,1QU2F@1224|Proteobacteria,42P7H@68525|delta/epsilon subdivisions,2WKJA@28221|Deltaproteobacteria,2M9BR@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
CMS2_k127_896682_8	886379.AEWI01000012_gene1044	1.247e-59	215.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_896682_19	596324.TREVI0001_0845	1.368e-07	61.0	COG1131@1|root,COG1131@2|Bacteria,2J6HQ@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS2_k127_896682_9	1519464.HY22_02245	1.679e-47	174.0	COG4914@1|root,COG4914@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204
CMS2_k127_896682_0	632518.Calow_0325	3.092e-171	567.0	COG5512@1|root,COG5512@2|Bacteria,1TR27@1239|Firmicutes,247Z8@186801|Clostridia,42HVD@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF4038)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
CMS2_k127_896682_20	1869.MB27_29225	1.657e-07	65.0	COG2133@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,2GJFY@201174|Actinobacteria,4DBK6@85008|Micromonosporales	201174|Actinobacteria	G	Cellulose Binding Domain Type IV	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,DUF1080,GSDH,PKD,RicinB_lectin_2,Ricin_B_lectin,ThuA
CMS2_k127_896682_15	1408473.JHXO01000002_gene3798	4.432e-21	109.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Flg_new,Fn3_assoc,LRR_5,LTD,Peptidase_S9,SpvB,TcdB_toxin_midN,VCBS
CMS2_k127_896682_3	243090.RB3493	1.405e-131	426.0	COG1879@1|root,COG1879@2|Bacteria,2IYMH@203682|Planctomycetes	203682|Planctomycetes	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
CMS2_k127_896682_14	1121481.AUAS01000009_gene97	8.784e-26	116.0	COG5618@1|root,COG5618@2|Bacteria,4NRFA@976|Bacteroidetes,47UUR@768503|Cytophagia	976|Bacteroidetes	S	Predicted periplasmic lipoprotein (DUF2291)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2291
CMS2_k127_896682_7	926556.Echvi_1282	1.609e-62	220.0	COG1129@1|root,COG1129@2|Bacteria,4PKJP@976|Bacteroidetes,47JPJ@768503|Cytophagia	976|Bacteroidetes	G	ABC transporter	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
CMS2_k127_899692_0	1267535.KB906767_gene3131	4.003e-143	482.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria,2JI3C@204432|Acidobacteriia	204432|Acidobacteriia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS2_k127_899692_1	1387312.BAUS01000004_gene1645	1.49e-71	262.0	COG1538@1|root,COG1538@2|Bacteria,1NEHN@1224|Proteobacteria,2VYWE@28216|Betaproteobacteria,2KKVJ@206350|Nitrosomonadales	206350|Nitrosomonadales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS2_k127_899692_5	706587.Desti_2663	6.642e-20	93.0	COG1503@1|root,COG1503@2|Bacteria,1MXX2@1224|Proteobacteria,42U2M@68525|delta/epsilon subdivisions,2WQS1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_899692_2	909663.KI867151_gene3160	1.914e-67	243.0	COG2197@1|root,COG2197@2|Bacteria,1RARA@1224|Proteobacteria,43B1G@68525|delta/epsilon subdivisions,2X5U5@28221|Deltaproteobacteria,2MRK4@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS2_k127_899692_3	1541065.JRFE01000013_gene2893	1.743e-23	102.0	COG1278@1|root,COG1278@2|Bacteria,1G5DM@1117|Cyanobacteria,3VKKP@52604|Pleurocapsales	1117|Cyanobacteria	K	'Cold-shock' DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
CMS2_k127_899692_6	313612.L8106_26742	1.524e-16	85.0	COG1278@1|root,COG1278@2|Bacteria,1G5DM@1117|Cyanobacteria,1HFFF@1150|Oscillatoriales	1117|Cyanobacteria	K	'Cold-shock' DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
CMS2_k127_899692_4	1121405.dsmv_1616	2.437e-21	97.0	COG3861@1|root,COG3861@2|Bacteria,1RD6Y@1224|Proteobacteria,437EH@68525|delta/epsilon subdivisions,2XA2G@28221|Deltaproteobacteria,2MNAI@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_899692_7	1142394.PSMK_04880	7.904e-11	74.0	COG2165@1|root,COG2165@2|Bacteria,2IY1V@203682|Planctomycetes	203682|Planctomycetes	NU	TIGRFAM prepilin-type N-terminal cleavage methylation domain	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
CMS2_k127_921067_22	469381.Dpep_0907	3.147e-28	132.0	COG3210@1|root,COG5492@1|root,COG3210@2|Bacteria,COG5492@2|Bacteria,3TB3U@508458|Synergistetes	508458|Synergistetes	U	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_921067_29	192952.MM_1119	1.736e-13	84.0	arCOG03500@1|root,arCOG03500@2157|Archaea	2157|Archaea	P	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	Disaggr_assoc
CMS2_k127_921067_11	745411.B3C1_07014	1.014e-61	226.0	COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,1RMHA@1236|Gammaproteobacteria,1J4V3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
CMS2_k127_921067_21	1121448.DGI_1085	3.26e-30	130.0	COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,42NX7@68525|delta/epsilon subdivisions,2WQ35@28221|Deltaproteobacteria,2MGD6@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
CMS2_k127_921067_10	1385510.N781_12150	3.772e-62	223.0	COG1338@1|root,COG1338@2|Bacteria,1TPIE@1239|Firmicutes,4HA79@91061|Bacilli,2Y8PQ@289201|Pontibacillus	91061|Bacilli	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
CMS2_k127_921067_36	177439.DP2670	7.927e-05	52.0	COG3190@1|root,COG3190@2|Bacteria	2|Bacteria	N	flagellar	fliZ	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
CMS2_k127_921067_39	690850.Desaf_1180	0.0008231	51.0	COG1360@1|root,COG1360@2|Bacteria,1RE7C@1224|Proteobacteria,42S5C@68525|delta/epsilon subdivisions,2WNMK@28221|Deltaproteobacteria,2M8P5@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	PFAM OmpA MotB domain protein	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
CMS2_k127_921067_31	1121406.JAEX01000013_gene1280	1.383e-08	64.0	COG1360@1|root,COG1360@2|Bacteria,1RE7C@1224|Proteobacteria,42S5C@68525|delta/epsilon subdivisions,2WNMK@28221|Deltaproteobacteria,2M8P5@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	PFAM OmpA MotB domain protein	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
CMS2_k127_921067_7	237368.SCABRO_00045	2.877e-68	243.0	COG1291@1|root,COG1291@2|Bacteria,2IY3Y@203682|Planctomycetes	203682|Planctomycetes	N	COG1291 Flagellar motor component	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
CMS2_k127_921067_38	1123508.JH636439_gene784	0.0007058	50.0	2FFQ4@1|root,347MF@2|Bacteria,2J3YA@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_921067_3	555079.Toce_1098	4.49e-149	484.0	COG1157@1|root,COG1157@2|Bacteria,1TP0R@1239|Firmicutes,25E6B@186801|Clostridia,42EPE@68295|Thermoanaerobacterales	186801|Clostridia	NU	PFAM H transporting two-sector ATPase alpha beta subunit central region	fliI	-	3.6.3.14	ko:K02412,ko:K03224	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko01000,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
CMS2_k127_921067_32	401526.TcarDRAFT_2139	1.663e-08	63.0	COG1317@1|root,COG1317@2|Bacteria,1VEUV@1239|Firmicutes,4H4F2@909932|Negativicutes	909932|Negativicutes	N	flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
CMS2_k127_921067_19	694431.DESACE_07455	1.428e-36	153.0	COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,42MS3@68525|delta/epsilon subdivisions,2WMCR@28221|Deltaproteobacteria,2M6R7@213113|Desulfurellales	28221|Deltaproteobacteria	N	FliG middle domain	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
CMS2_k127_921067_8	945713.IALB_2543	3.484e-67	247.0	COG1766@1|root,COG1766@2|Bacteria	2|Bacteria	N	bacterial-type flagellum-dependent cell motility	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
CMS2_k127_921067_37	498211.CJA_1712	9.637e-05	49.0	COG1677@1|root,COG1677@2|Bacteria,1N6RZ@1224|Proteobacteria,1SD52@1236|Gammaproteobacteria,1FHI2@10|Cellvibrio	1236|Gammaproteobacteria	N	Flagellar hook-basal body complex protein FliE	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
CMS2_k127_921067_24	1380390.JIAT01000009_gene1754	5.856e-27	114.0	COG1558@1|root,COG1558@2|Bacteria,2IKRZ@201174|Actinobacteria,4CSEX@84995|Rubrobacteria	84995|Rubrobacteria	N	Flagellar basal body rod FlgEFG protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Flg_bb_rod,Flg_bbr_C
CMS2_k127_921067_27	1120972.AUMH01000011_gene223	4.898e-15	81.0	COG1815@1|root,COG1815@2|Bacteria,1VEUZ@1239|Firmicutes,4HIKW@91061|Bacilli	91061|Bacilli	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
CMS2_k127_921067_34	1210884.HG799473_gene15030	3.471e-06	59.0	COG3144@1|root,COG3144@2|Bacteria	2|Bacteria	N	bacterial-type flagellum assembly	fliK	-	-	ko:K02414	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_hook
CMS2_k127_921067_6	643562.Daes_1109	1.087e-71	250.0	COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,42MX8@68525|delta/epsilon subdivisions,2WKE1@28221|Deltaproteobacteria,2M9GW@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	fliC	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_IN,Flagellin_N
CMS2_k127_921067_25	574087.Acear_0257	3.807e-24	107.0	COG1516@1|root,COG1516@2|Bacteria,1VA8K@1239|Firmicutes,24MRW@186801|Clostridia,3WAV1@53433|Halanaerobiales	186801|Clostridia	N	TIGRFAM flagellar biosynthetic protein FliS	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
CMS2_k127_921067_5	795359.TOPB45_0364	1.512e-74	270.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	wzi	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi,PAP2
CMS2_k127_921067_0	243231.GSU1842	5.649e-198	650.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,42M62@68525|delta/epsilon subdivisions,2WJ83@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Polysaccharide export protein	-	-	-	-	-	-	-	-	-	-	-	-	Poly_export,SLBB
CMS2_k127_921067_33	335543.Sfum_0789	6.193e-08	64.0	COG3206@1|root,COG3944@1|root,COG3206@2|Bacteria,COG3944@2|Bacteria,1QUY4@1224|Proteobacteria,42RD1@68525|delta/epsilon subdivisions,2WMV4@28221|Deltaproteobacteria,2MQDI@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	G-rich domain on putative tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
CMS2_k127_921067_18	269799.Gmet_2011	9.135e-41	160.0	COG2227@1|root,COG2227@2|Bacteria,1NBIU@1224|Proteobacteria,43CAM@68525|delta/epsilon subdivisions,2WWNH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_921067_13	1041930.Mtc_0198	8.25e-56	213.0	COG1216@1|root,arCOG01383@2157|Archaea,2XUCM@28890|Euryarchaeota,2NAQ3@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3
CMS2_k127_921067_35	1547445.LO80_08515	4.843e-06	59.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
CMS2_k127_921067_17	118168.MC7420_2219	6.676e-44	176.0	COG4627@1|root,COG4627@2|Bacteria,1G57B@1117|Cyanobacteria,1HAWR@1150|Oscillatoriales	1117|Cyanobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_921067_2	768671.ThimaDRAFT_4861	4.418e-169	535.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,1RNJD@1236|Gammaproteobacteria,1WX9A@135613|Chromatiales	135613|Chromatiales	GM	PFAM NAD-dependent epimerase dehydratase	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
CMS2_k127_921067_4	1121405.dsmv_0721	2.836e-87	308.0	COG0438@1|root,COG0438@2|Bacteria,1RJ6C@1224|Proteobacteria	1224|Proteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS2_k127_921067_23	1189620.AJXL01000020_gene1592	3.815e-28	130.0	COG2242@1|root,COG2242@2|Bacteria,4NUNT@976|Bacteroidetes,1IN6Q@117743|Flavobacteriia,2NY3R@237|Flavobacterium	976|Bacteroidetes	H	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
CMS2_k127_921067_15	886379.AEWI01000043_gene3305	7.559e-53	197.0	COG1216@1|root,COG1216@2|Bacteria,4NIW6@976|Bacteroidetes,2FSMP@200643|Bacteroidia,3XKH5@558415|Marinilabiliaceae	976|Bacteroidetes	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_921067_16	794903.OPIT5_28420	2.184e-49	191.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
CMS2_k127_921067_12	317936.Nos7107_0157	4.762e-61	227.0	COG0438@1|root,COG0438@2|Bacteria,1G55M@1117|Cyanobacteria	1117|Cyanobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
CMS2_k127_921067_28	1449048.JQKU01000024_gene4046	9.412e-15	87.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,235A2@1762|Mycobacteriaceae	201174|Actinobacteria	M	GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
CMS2_k127_921067_30	768704.Desmer_2948	6.816e-10	69.0	COG0500@1|root,COG2226@2|Bacteria,1VBKM@1239|Firmicutes,25B5V@186801|Clostridia,2672X@186807|Peptococcaceae	186801|Clostridia	Q	Protein of unknown function (DUF1698)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS2_k127_921067_9	1499683.CCFF01000017_gene2741	2.161e-64	237.0	COG0438@1|root,COG0438@2|Bacteria,1TSYS@1239|Firmicutes,25B28@186801|Clostridia,36WDJ@31979|Clostridiaceae	186801|Clostridia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_921067_20	1211813.CAPH01000007_gene1879	2.334e-30	126.0	COG0381@1|root,COG0381@2|Bacteria,4NGBD@976|Bacteroidetes,2FM5D@200643|Bacteroidia	976|Bacteroidetes	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
CMS2_k127_921067_14	518766.Rmar_1487	4.595e-54	199.0	COG2148@1|root,COG2148@2|Bacteria,4NFIA@976|Bacteroidetes,1FK8J@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
CMS2_k127_921067_1	761193.Runsl_2879	1.617e-181	578.0	COG0673@1|root,COG0673@2|Bacteria,4NDYI@976|Bacteroidetes,47NPG@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_956667_3	1122917.KB899666_gene3395	7.107e-44	177.0	COG2160@1|root,COG2160@2|Bacteria	2|Bacteria	G	L-arabinose isomerase activity	-	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Iso_C,Arabinose_Isome,Fucose_iso_C
CMS2_k127_956667_6	696369.KI912183_gene1932	5.802e-36	151.0	COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,25C4D@186801|Clostridia,265SM@186807|Peptococcaceae	186801|Clostridia	GK	DeoR C terminal sensor domain	-	-	-	ko:K02081,ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
CMS2_k127_956667_4	1499967.BAYZ01000032_gene1135	3.285e-42	173.0	COG4992@1|root,COG4992@2|Bacteria	2|Bacteria	E	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	-	-	2.6.1.11,2.6.1.17,2.6.1.82	ko:K00821,ko:K09251	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R01155,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS2_k127_956667_2	1499967.BAYZ01000123_gene2492	3.844e-131	428.0	COG3618@1|root,COG3618@2|Bacteria	2|Bacteria	H	amidohydrolase	-	-	5.4.3.8	ko:K01845,ko:K07100	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Amidohydro_2,Aminotran_3
CMS2_k127_956667_0	314230.DSM3645_14940	1.333e-236	748.0	COG4146@1|root,COG4146@2|Bacteria,2J29I@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
CMS2_k127_956667_1	314230.DSM3645_14945	8.261e-171	546.0	COG0673@1|root,COG0673@2|Bacteria,2IXUF@203682|Planctomycetes	2|Bacteria	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS2_k127_956667_8	383372.Rcas_4129	1.127e-06	60.0	COG0823@1|root,COG0823@2|Bacteria,2G8PZ@200795|Chloroflexi,377MH@32061|Chloroflexia	32061|Chloroflexia	U	WD40 domain protein beta Propeller	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
CMS2_k127_956667_7	1254432.SCE1572_06790	2.773e-17	94.0	290ZT@1|root,2ZNMH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_956667_5	649638.Trad_2830	6.101e-40	155.0	COG1696@1|root,COG1696@2|Bacteria,1WM4V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	MBOAT, membrane-bound O-acyltransferase family	-	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
CMS2_k127_960654_0	237368.SCABRO_01083	2.446e-142	455.0	COG0008@1|root,COG0008@2|Bacteria,2IYSE@203682|Planctomycetes	203682|Planctomycetes	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
CMS2_k127_960654_11	391623.TERMP_00457	1.359e-15	78.0	COG1656@1|root,COG2442@1|root,arCOG04290@2157|Archaea,arCOG07520@2157|Archaea,2Y1HG@28890|Euryarchaeota,244W7@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
CMS2_k127_960654_12	794903.OPIT5_19320	2.959e-07	56.0	COG4634@1|root,COG4634@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C
CMS2_k127_960654_10	1177594.MIC448_830010	8.205e-23	115.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CarboxypepD_reg,HemolysinCabind
CMS2_k127_960654_7	439235.Dalk_3703	5.748e-42	176.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_960654_6	575540.Isop_3117	8.149e-44	168.0	COG0500@1|root,COG2226@2|Bacteria,2J12F@203682|Planctomycetes	203682|Planctomycetes	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS2_k127_960654_3	240016.ABIZ01000001_gene1339	7.332e-67	245.0	COG0463@1|root,COG0463@2|Bacteria,46SXD@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS2_k127_960654_5	671143.DAMO_3128	1.668e-44	165.0	COG0730@1|root,COG0730@2|Bacteria,2NRPD@2323|unclassified Bacteria	2|Bacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS2_k127_960654_2	1142394.PSMK_15840	1.548e-76	265.0	COG0134@1|root,COG0134@2|Bacteria,2IX3M@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
CMS2_k127_960654_13	639030.JHVA01000001_gene3456	2.522e-06	55.0	29CGV@1|root,2ZZF9@2|Bacteria,3Y4JX@57723|Acidobacteria,2JJ9Y@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
CMS2_k127_960654_4	1158318.ATXC01000001_gene1311	1.438e-44	168.0	COG0691@1|root,COG0691@2|Bacteria,2G4Z6@200783|Aquificae	200783|Aquificae	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
CMS2_k127_960654_9	575540.Isop_0191	7.341e-27	122.0	COG0515@1|root,COG0515@2|Bacteria,2IZFV@203682|Planctomycetes	203682|Planctomycetes	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS2_k127_960654_8	1123508.JH636440_gene2408	4.963e-38	147.0	COG0818@1|root,COG0818@2|Bacteria,2J1DU@203682|Planctomycetes	203682|Planctomycetes	M	Diacylglycerol kinase	-	-	2.7.1.107	ko:K00901	ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar
CMS2_k127_960654_1	497964.CfE428DRAFT_1820	1.359e-127	416.0	COG1506@1|root,COG1506@2|Bacteria,46UJ0@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
CMS2_k127_962266_2	1122212.AULO01000008_gene1579	1.115e-10	72.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1XJAY@135619|Oceanospirillales	135619|Oceanospirillales	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS2_k127_962266_0	1304874.JAFY01000001_gene2612	4.692e-47	193.0	COG3210@1|root,COG4447@1|root,COG3210@2|Bacteria,COG4447@2|Bacteria,3TB3U@508458|Synergistetes	508458|Synergistetes	U	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS2_k127_962266_3	192952.MM_1145	5.532e-10	73.0	arCOG03500@1|root,arCOG03500@2157|Archaea	2157|Archaea	P	Disaggregatase related	-	-	-	-	-	-	-	-	-	-	-	-	Disaggr_assoc
CMS2_k127_962266_1	1200792.AKYF01000010_gene2627	1.198e-15	78.0	COG3682@1|root,COG3682@2|Bacteria,1V7EY@1239|Firmicutes,4HP8S@91061|Bacilli,276QT@186822|Paenibacillaceae	91061|Bacilli	K	Penicillinase repressor	copY	-	-	ko:K02171	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01504,ko03000	-	-	-	Penicillinase_R
CMS2_k127_988333_2	869213.JCM21142_41533	7.174e-54	194.0	COG3808@1|root,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,47MRY@768503|Cytophagia	976|Bacteroidetes	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase,OmpA
CMS2_k127_988333_0	1089553.Tph_c25470	8.697e-102	344.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,42F14@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
CMS2_k127_988333_3	1496688.ER33_13980	1.058e-07	56.0	COG5450@1|root,COG5450@2|Bacteria,1GAQ0@1117|Cyanobacteria	1117|Cyanobacteria	K	Transcription regulator of the Arc MetJ class	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
CMS2_k127_988333_4	643648.Slip_1894	1.604e-06	54.0	28JE3@1|root,2Z98B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS2_k127_988333_1	190650.CC_2963	2.523e-74	259.0	COG0388@1|root,COG0388@2|Bacteria,1RCR6@1224|Proteobacteria,2U6JN@28211|Alphaproteobacteria,2KJ6J@204458|Caulobacterales	204458|Caulobacterales	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
## 4542 queries scanned
## Total time (seconds): 220.59932827949524
## Rate: 20.59 q/s