## Sat Nov  9 21:29:44 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bins_4635/CMS3_bin.135.fa -m mmseqs --itype genome -o CMS3_bin.135 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/CMS3_bin.135 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
CMS3_k127_1005655_17	479434.Sthe_3197	8.363e-42	163.0	COG1595@1|root,COG1595@2|Bacteria,2G6UE@200795|Chloroflexi,27YAV@189775|Thermomicrobia	189775|Thermomicrobia	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1005655_21	1131269.AQVV01000001_gene1432	6.674e-29	129.0	COG1573@1|root,COG1573@2|Bacteria	2|Bacteria	L	deaminated base DNA N-glycosylase activity	ung2	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS3_k127_1005655_32	288000.BBta_4998	9.651e-08	59.0	COG0346@1|root,COG0346@2|Bacteria,1RB65@1224|Proteobacteria,2U7DP@28211|Alphaproteobacteria,3JYA1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	MA20_35640	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
CMS3_k127_1005655_31	1336208.JADY01000024_gene3821	1.844e-11	77.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2TV0X@28211|Alphaproteobacteria,2JPU1@204441|Rhodospirillales	204441|Rhodospirillales	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
CMS3_k127_1005655_24	398578.Daci_5047	1.63e-21	102.0	COG0454@1|root,COG0456@2|Bacteria,1RKFU@1224|Proteobacteria,2VUBE@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_1005655_3	309801.trd_1049	1.965e-173	565.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,2G674@200795|Chloroflexi,27Z2G@189775|Thermomicrobia	189775|Thermomicrobia	E	Homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
CMS3_k127_1005655_30	1094980.Mpsy_0691	1.177e-12	74.0	COG1983@1|root,arCOG03456@2157|Archaea,2XZT2@28890|Euryarchaeota,2NBEK@224756|Methanomicrobia	224756|Methanomicrobia	K	PspC domain	-	-	-	-	-	-	-	-	-	-	-	-	PspC
CMS3_k127_1005655_23	525904.Tter_1832	7.866e-25	109.0	COG1673@1|root,COG1673@2|Bacteria	2|Bacteria	L	EVE domain	ydcG	-	-	-	-	-	-	-	-	-	-	-	EVE
CMS3_k127_1005655_20	1382356.JQMP01000004_gene590	1.273e-30	126.0	COG0316@1|root,COG0316@2|Bacteria,2G705@200795|Chloroflexi,27YEW@189775|Thermomicrobia	189775|Thermomicrobia	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
CMS3_k127_1005655_27	1122917.KB899660_gene2022	2.368e-17	91.0	COG2345@1|root,COG2345@2|Bacteria,1V5Q5@1239|Firmicutes,4HHMX@91061|Bacilli,26U3B@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,HTH_24,HTH_5,HTH_DeoR
CMS3_k127_1005655_7	768710.DesyoDRAFT_0866	3.621e-109	370.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,25ZZ7@186807|Peptococcaceae	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS3_k127_1005655_12	1449126.JQKL01000022_gene118	1.141e-64	230.0	COG0377@1|root,COG0377@2|Bacteria,1TZS1@1239|Firmicutes,24GH5@186801|Clostridia	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
CMS3_k127_1005655_19	626887.J057_15520	1.301e-35	141.0	293MU@1|root,2ZR3M@2|Bacteria,1REEY@1224|Proteobacteria,1S3UE@1236|Gammaproteobacteria,46B1B@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Nickel-containing superoxide dismutase	-	-	1.15.1.1	ko:K00518	-	-	-	-	ko00000,ko01000	-	-	-	Sod_Ni
CMS3_k127_1005655_26	69042.WH5701_12683	4.747e-18	91.0	COG0681@1|root,COG0681@2|Bacteria,1G519@1117|Cyanobacteria,1GZMB@1129|Synechococcus	1117|Cyanobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
CMS3_k127_1005655_0	309801.trd_1300	7.596e-211	669.0	COG0459@1|root,COG0459@2|Bacteria,2G65N@200795|Chloroflexi,27Y1U@189775|Thermomicrobia	189775|Thermomicrobia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS3_k127_1005655_22	316274.Haur_2160	1.044e-27	117.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	1.20.4.3	ko:K18917	-	-	-	-	ko00000,ko01000	-	-	-	Glutaredoxin
CMS3_k127_1005655_11	1380390.JIAT01000009_gene671	3.563e-87	306.0	COG0477@1|root,COG2814@2|Bacteria,2I2DZ@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
CMS3_k127_1005655_25	1313172.YM304_41730	4.219e-21	103.0	2DQVM@1|root,338Y0@2|Bacteria	2|Bacteria	S	lipid binding	lprG	GO:0003674,GO:0005102,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008289,GO:0009405,GO:0009605,GO:0009607,GO:0009966,GO:0010469,GO:0010646,GO:0016020,GO:0020012,GO:0023051,GO:0030312,GO:0030545,GO:0030682,GO:0031982,GO:0035091,GO:0042783,GO:0042785,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043230,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044421,GO:0044464,GO:0048018,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051812,GO:0051832,GO:0051834,GO:0051861,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0065009,GO:0071944,GO:0075136,GO:0097367,GO:0097691,GO:0098772,GO:1903561	-	ko:K14954,ko:K14955	ko05152,map05152	-	-	-	ko00000,ko00001	-	-	-	LppX_LprAFG
CMS3_k127_1005655_9	479434.Sthe_0838	9.208e-101	338.0	COG0709@1|root,COG0709@2|Bacteria,2G5W4@200795|Chloroflexi,27XGA@189775|Thermomicrobia	189775|Thermomicrobia	H	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
CMS3_k127_1005655_13	479434.Sthe_1073	8.171e-62	220.0	COG0177@1|root,COG0177@2|Bacteria,2G6QA@200795|Chloroflexi	200795|Chloroflexi	L	FES	-	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
CMS3_k127_1005655_18	1341151.ASZU01000018_gene1005	1.159e-35	142.0	COG1247@1|root,COG1247@2|Bacteria,1V3V3@1239|Firmicutes,4HHNY@91061|Bacilli,27CEF@186824|Thermoactinomycetaceae	91061|Bacilli	M	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
CMS3_k127_1005655_8	292459.STH2890	3.959e-101	347.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
CMS3_k127_1005655_15	485913.Krac_9969	5.219e-52	194.0	COG0548@1|root,COG0548@2|Bacteria,2G6ZG@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
CMS3_k127_1005655_1	643648.Slip_1163	6.061e-208	678.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,42JMJ@68298|Syntrophomonadaceae	186801|Clostridia	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
CMS3_k127_1005655_6	243164.DET1258	3.074e-126	417.0	COG4992@1|root,COG4992@2|Bacteria,2G5TW@200795|Chloroflexi,34D4B@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_1005655_5	1123508.JH636449_gene7327	1.581e-144	469.0	COG0137@1|root,COG0137@2|Bacteria,2IX1G@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
CMS3_k127_1005655_4	1279019.ARQK01000057_gene839	3.556e-164	529.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1WWNX@135613|Chromatiales	135613|Chromatiales	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
CMS3_k127_1005655_16	439292.Bsel_1697	2.91e-47	180.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,26NTF@186821|Sporolactobacillaceae	91061|Bacilli	G	Ribulose-phosphate 3 epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
CMS3_k127_1005655_29	525904.Tter_1653	4.392e-13	73.0	COG0227@1|root,COG0227@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
CMS3_k127_1005655_10	665952.HMPREF1015_00794	6.059e-99	343.0	COG1461@1|root,COG1461@2|Bacteria,1TQMX@1239|Firmicutes,4HBSE@91061|Bacilli,1ZBRP@1386|Bacillus	91061|Bacilli	S	kinase related to dihydroxyacetone kinase	yloV	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
CMS3_k127_1005655_14	1128421.JAGA01000002_gene202	5.543e-56	207.0	COG1307@1|root,COG1307@2|Bacteria,2NQTE@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein, DegV family COG1307	degV	-	-	-	-	-	-	-	-	-	-	-	DegV
CMS3_k127_1005655_2	311424.DhcVS_1051	3.245e-200	662.0	COG1200@1|root,COG1200@2|Bacteria,2G5YM@200795|Chloroflexi,34D01@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
CMS3_k127_1008750_1	255470.cbdbA274	5.898e-76	267.0	COG0342@1|root,COG0342@2|Bacteria,2G5K5@200795|Chloroflexi,34CQF@301297|Dehalococcoidia	301297|Dehalococcoidia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF
CMS3_k127_1008750_3	887929.HMP0721_0235	3.589e-07	57.0	COG1862@1|root,COG1862@2|Bacteria,1VEMC@1239|Firmicutes,24MMT@186801|Clostridia,25WYU@186806|Eubacteriaceae	186801|Clostridia	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
CMS3_k127_1008750_2	552811.Dehly_0643	2.903e-45	170.0	COG0242@1|root,COG0242@2|Bacteria,2G6VE@200795|Chloroflexi,34CVZ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
CMS3_k127_1008750_0	311424.DhcVS_278	3.644e-114	381.0	COG1198@1|root,COG1198@2|Bacteria,2G60J@200795|Chloroflexi,34D0F@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Helicase_C,ResIII
CMS3_k127_101168_23	38833.XP_003061737.1	4.339e-44	181.0	2CWGT@1|root,2S4IK@2759|Eukaryota,37ZNN@33090|Viridiplantae,34KHX@3041|Chlorophyta	3041|Chlorophyta	S	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
CMS3_k127_101168_7	1382356.JQMP01000003_gene2139	4.263e-117	392.0	COG0686@1|root,COG0686@2|Bacteria,2G68X@200795|Chloroflexi,27YU4@189775|Thermomicrobia	189775|Thermomicrobia	C	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
CMS3_k127_101168_13	880072.Desac_1681	7.982e-81	278.0	COG0223@1|root,COG0223@2|Bacteria,1MW07@1224|Proteobacteria	1224|Proteobacteria	J	Methionyl-tRNA formyltransferase	-	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
CMS3_k127_101168_19	1459636.NTE_03049	1.049e-51	193.0	COG0122@1|root,arCOG00464@2157|Archaea	2157|Archaea	L	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
CMS3_k127_101168_22	91464.S7335_3783	3.627e-44	168.0	COG0563@1|root,COG0563@2|Bacteria,1G696@1117|Cyanobacteria	1117|Cyanobacteria	F	COG0563 Adenylate kinase and related	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18,PduV-EutP,SKI
CMS3_k127_101168_15	1137269.AZWL01000001_gene6125	2.969e-75	266.0	COG1162@1|root,COG1162@2|Bacteria,2GMDX@201174|Actinobacteria	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
CMS3_k127_101168_14	324602.Caur_1462	1.027e-79	274.0	COG1028@1|root,COG1028@2|Bacteria,2G5KB@200795|Chloroflexi,376QP@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_101168_2	292459.STH1186	3.861e-208	663.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia	186801|Clostridia	I	PFAM Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
CMS3_k127_101168_26	1009370.ALO_21334	6.543e-32	131.0	COG2030@1|root,COG2030@2|Bacteria,1V6MY@1239|Firmicutes,4H46U@909932|Negativicutes	909932|Negativicutes	I	MaoC domain protein dehydratase	-	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
CMS3_k127_101168_30	106370.Francci3_1659	5.693e-20	101.0	COG2345@1|root,COG2345@2|Bacteria,2GN8W@201174|Actinobacteria,4ESM6@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator	sufR	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,HTH_24,HTH_5,MarR_2
CMS3_k127_101168_12	1379698.RBG1_1C00001G0735	1.073e-88	301.0	COG0396@1|root,COG0396@2|Bacteria,2NNYE@2323|unclassified Bacteria	2|Bacteria	O	ABC transporter	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
CMS3_k127_101168_0	926550.CLDAP_20350	3.028e-219	689.0	COG0719@1|root,COG0719@2|Bacteria,2G5TI@200795|Chloroflexi	200795|Chloroflexi	O	TIGRFAM FeS assembly protein SufB	sufB	-	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
CMS3_k127_101168_21	1379698.RBG1_1C00001G0737	3.903e-45	184.0	COG0719@1|root,COG0719@2|Bacteria,2NPGC@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufD	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0040007,GO:0043207,GO:0044085,GO:0044237,GO:0044403,GO:0044419,GO:0050896,GO:0051186,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071840,GO:0075136	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
CMS3_k127_101168_29	926550.CLDAP_20390	2.094e-22	104.0	COG2146@1|root,COG2146@2|Bacteria,2G7AG@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Rieske 2Fe-2S domain protein	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
CMS3_k127_101168_5	266117.Rxyl_0166	1.335e-167	537.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,4CPE2@84995|Rubrobacteria	84995|Rubrobacteria	E	Aminotransferase class-V	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
CMS3_k127_101168_24	751945.Theos_0085	7.902e-38	148.0	COG0822@1|root,COG0822@2|Bacteria,1WJS9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	SUF system FeS assembly protein	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
CMS3_k127_101168_28	1122128.AUEE01000002_gene1092	1.348e-23	112.0	COG2151@1|root,COG2151@2|Bacteria,1V9YV@1239|Firmicutes,4HKC6@91061|Bacilli,4GZFP@90964|Staphylococcaceae	91061|Bacilli	S	Iron-sulfur cluster assembly protein	yitW	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
CMS3_k127_101168_8	357808.RoseRS_3607	5.489e-108	365.0	COG0247@1|root,COG0247@2|Bacteria,2G5V8@200795|Chloroflexi,37729@32061|Chloroflexia	32061|Chloroflexia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
CMS3_k127_101168_18	1382356.JQMP01000003_gene2354	4.355e-54	206.0	COG0277@1|root,COG0277@2|Bacteria,2G6FW@200795|Chloroflexi,27XX4@189775|Thermomicrobia	189775|Thermomicrobia	C	FAD linked oxidases, C-terminal domain	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
CMS3_k127_101168_6	485913.Krac_10287	1.235e-152	501.0	COG0277@1|root,COG0277@2|Bacteria,2G5TM@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD linked oxidase domain protein	-	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
CMS3_k127_101168_17	1536769.P40081_14585	4.133e-68	240.0	COG1028@1|root,COG1028@2|Bacteria,1V05R@1239|Firmicutes,4HDCM@91061|Bacilli,26S71@186822|Paenibacillaceae	91061|Bacilli	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	yusR	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
CMS3_k127_101168_27	684949.ATTJ01000001_gene2105	2.431e-27	126.0	COG0483@1|root,COG0483@2|Bacteria	2|Bacteria	G	inositol monophosphate 1-phosphatase activity	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
CMS3_k127_101168_16	1185876.BN8_06442	1.152e-68	241.0	COG0500@1|root,COG0500@2|Bacteria,4PPT2@976|Bacteroidetes,47P93@768503|Cytophagia	976|Bacteroidetes	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_101168_20	1259795.ARJK01000002_gene31	3.091e-50	195.0	COG0477@1|root,COG2814@2|Bacteria,1TRUT@1239|Firmicutes,25E84@186801|Clostridia,42FN6@68295|Thermoanaerobacterales	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_101168_9	368407.Memar_1826	1.556e-104	354.0	COG0531@1|root,arCOG00009@2157|Archaea,2XTX6@28890|Euryarchaeota,2N9VR@224756|Methanomicrobia	224756|Methanomicrobia	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
CMS3_k127_101168_1	479434.Sthe_2669	1.542e-217	720.0	COG1067@1|root,COG1067@2|Bacteria,2G64R@200795|Chloroflexi,27XSI@189775|Thermomicrobia	189775|Thermomicrobia	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
CMS3_k127_101168_10	760568.Desku_1351	1.463e-102	370.0	COG2079@1|root,COG2079@2|Bacteria,1TSD7@1239|Firmicutes,24BFZ@186801|Clostridia,260NH@186807|Peptococcaceae	186801|Clostridia	S	PFAM MmgE PrpD	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
CMS3_k127_101168_11	485913.Krac_12069	2.947e-100	337.0	COG0604@1|root,COG0604@2|Bacteria,2G7Z0@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_101168_31	688269.Theth_1497	2.448e-16	89.0	COG0467@1|root,COG0467@2|Bacteria,2GDRG@200918|Thermotogae	200918|Thermotogae	T	GvpD gas vesicle protein	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
CMS3_k127_101168_25	1540221.JQNI01000002_gene1131	1.406e-32	135.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
CMS3_k127_101168_32	1340493.JNIF01000003_gene2641	1.077e-09	66.0	2AYX9@1|root,31R2Z@2|Bacteria,3Y4ZH@57723|Acidobacteria	57723|Acidobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS3_k127_101168_4	876044.IMCC3088_1268	2.746e-168	542.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,1J56Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
CMS3_k127_101168_3	926550.CLDAP_19190	1.086e-206	657.0	COG0365@1|root,COG0365@2|Bacteria,2G5KE@200795|Chloroflexi	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
CMS3_k127_101168_33	1169161.KB897740_gene2310	8.725e-05	54.0	COG3055@1|root,COG3055@2|Bacteria,2I91M@201174|Actinobacteria	201174|Actinobacteria	S	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,Kelch_4,Kelch_6
CMS3_k127_1014068_14	1123325.JHUV01000008_gene789	4.951e-64	227.0	COG1611@1|root,COG1611@2|Bacteria,2G4W3@200783|Aquificae	200783|Aquificae	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS3_k127_1014068_7	935839.JAGJ01000010_gene329	3.666e-101	338.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4F39X@85017|Promicromonosporaceae	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
CMS3_k127_1014068_28	999541.bgla_1g29610	2.345e-08	64.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2VIM1@28216|Betaproteobacteria,1K29G@119060|Burkholderiaceae	28216|Betaproteobacteria	KT	response regulator	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_1014068_21	1273538.G159_01735	3.17e-25	115.0	COG0596@1|root,COG0596@2|Bacteria,1UKJS@1239|Firmicutes,4ITJ3@91061|Bacilli,26EAB@186818|Planococcaceae	91061|Bacilli	S	Ndr family	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
CMS3_k127_1014068_31	1121937.AUHJ01000005_gene2327	2.472e-05	53.0	2DC7N@1|root,2ZD6A@2|Bacteria	2|Bacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
CMS3_k127_1014068_16	234267.Acid_5241	1.653e-54	200.0	COG1262@1|root,COG1262@2|Bacteria	234267.Acid_5241|-	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1014068_15	525904.Tter_1040	3.609e-55	211.0	COG2344@1|root,COG2344@2|Bacteria,2NPI1@2323|unclassified Bacteria	2|Bacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
CMS3_k127_1014068_2	1382356.JQMP01000003_gene1994	4.881e-131	427.0	COG1077@1|root,COG1077@2|Bacteria,2G5KV@200795|Chloroflexi,27Y3P@189775|Thermomicrobia	189775|Thermomicrobia	D	Cell division protein FtsA	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
CMS3_k127_1014068_6	1121428.DESHY_30127___1	8.608e-108	363.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,260JC@186807|Peptococcaceae	186801|Clostridia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
CMS3_k127_1014068_9	1122247.C731_0421	1.955e-87	299.0	COG1735@1|root,COG1735@2|Bacteria,2GMZ6@201174|Actinobacteria,2360H@1762|Mycobacteriaceae	201174|Actinobacteria	S	Phosphotriesterase	php	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
CMS3_k127_1014068_25	246194.CHY_2544	3.441e-20	96.0	COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia,42GKC@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01195	ATP-synt_DE,ATP-synt_DE_N
CMS3_k127_1014068_0	1321786.HMPREF1992_01868	2.556e-205	654.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,4H2IA@909932|Negativicutes	909932|Negativicutes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
CMS3_k127_1014068_10	479434.Sthe_1422	1.56e-83	286.0	COG0224@1|root,COG0224@2|Bacteria,2G69I@200795|Chloroflexi,27XXK@189775|Thermomicrobia	189775|Thermomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
CMS3_k127_1014068_1	1121430.JMLG01000002_gene1219	7.638e-200	634.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,260JV@186807|Peptococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
CMS3_k127_1014068_22	479434.Sthe_1424	1.147e-23	107.0	COG0712@1|root,COG0712@2|Bacteria,2G78B@200795|Chloroflexi,27YHC@189775|Thermomicrobia	189775|Thermomicrobia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
CMS3_k127_1014068_23	479434.Sthe_1425	3.345e-23	107.0	COG0711@1|root,COG0711@2|Bacteria,2G76T@200795|Chloroflexi,27YGB@189775|Thermomicrobia	189775|Thermomicrobia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
CMS3_k127_1014068_26	926550.CLDAP_05100	2.709e-19	92.0	COG0636@1|root,COG0636@2|Bacteria,2G72D@200795|Chloroflexi	200795|Chloroflexi	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
CMS3_k127_1014068_18	552811.Dehly_0545	2.133e-46	182.0	COG0356@1|root,COG0356@2|Bacteria,2G6NF@200795|Chloroflexi,34D35@301297|Dehalococcoidia	301297|Dehalococcoidia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
CMS3_k127_1014068_30	1121918.ARWE01000001_gene66	3.61e-06	53.0	COG5336@1|root,COG5336@2|Bacteria,1Q3U8@1224|Proteobacteria,437BR@68525|delta/epsilon subdivisions,2X2H2@28221|Deltaproteobacteria,43VQW@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	-	-	-	-	-	-	-	-	-	ATPase_gene1
CMS3_k127_1014068_19	311424.DhcVS_495	1.489e-43	166.0	COG1259@1|root,COG1259@2|Bacteria,2G6P6@200795|Chloroflexi,34DAC@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
CMS3_k127_1014068_27	479434.Sthe_0412	7.242e-15	85.0	COG4481@1|root,COG4481@2|Bacteria,2G9W8@200795|Chloroflexi,27YMV@189775|Thermomicrobia	189775|Thermomicrobia	S	Bacterial protein of unknown function (DUF951)	-	-	-	-	-	-	-	-	-	-	-	-	DUF951
CMS3_k127_1014068_11	479434.Sthe_0653	6.644e-76	264.0	COG0284@1|root,COG0284@2|Bacteria,2G692@200795|Chloroflexi,27XX0@189775|Thermomicrobia	189775|Thermomicrobia	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
CMS3_k127_1014068_17	322710.Avin_41440	1.703e-53	198.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,1RPU9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
CMS3_k127_1014068_24	861299.J421_3532	2.773e-22	106.0	COG2045@1|root,COG2045@2|Bacteria,1ZTM8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	2-phosphosulpholactate phosphatase	comB	-	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
CMS3_k127_1014068_12	479434.Sthe_2125	1.307e-73	264.0	COG1721@1|root,COG1721@2|Bacteria,2G6Y7@200795|Chloroflexi,27YYN@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_1014068_3	479434.Sthe_2126	1.695e-117	392.0	COG0714@1|root,COG0714@2|Bacteria,2G669@200795|Chloroflexi,27YUB@189775|Thermomicrobia	189775|Thermomicrobia	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_1014068_20	243090.RB3867	1.261e-41	162.0	COG3568@1|root,COG3568@2|Bacteria,2J2R6@203682|Planctomycetes	203682|Planctomycetes	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS3_k127_1014068_5	96561.Dole_0317	1.833e-112	388.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria,2MHYJ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM glutamate synthase (NADPH), homotetrameric	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
CMS3_k127_1014068_13	1380390.JIAT01000009_gene1363	6.293e-68	246.0	COG0654@1|root,COG0654@2|Bacteria,2I2TH@201174|Actinobacteria,4CU4I@84995|Rubrobacteria	84995|Rubrobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
CMS3_k127_1014068_29	1268072.PSAB_16215	3.234e-07	59.0	COG2318@1|root,COG2318@2|Bacteria,1VB99@1239|Firmicutes,4HNES@91061|Bacilli,26ZFK@186822|Paenibacillaceae	91061|Bacilli	S	DinB family	yisT	-	-	-	-	-	-	-	-	-	-	-	DinB
CMS3_k127_1014068_4	1382306.JNIM01000001_gene2563	1.091e-113	381.0	COG1058@1|root,COG1058@2|Bacteria,2G6DU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CinA,MoCF_biosynth
CMS3_k127_1014068_8	1343740.M271_44390	2.568e-99	332.0	COG0318@1|root,COG2141@1|root,COG0318@2|Bacteria,COG2141@2|Bacteria,2GMMJ@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_1030361_5	1411685.U062_00031	3.016e-10	65.0	2BQ7M@1|root,32J2C@2|Bacteria,1R32K@1224|Proteobacteria,1T61Z@1236|Gammaproteobacteria,1JBGM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Glutaredoxin-like domain (DUF836)	-	-	-	-	-	-	-	-	-	-	-	-	DUF836
CMS3_k127_1030361_4	102125.Xen7305DRAFT_00013610	2.858e-35	147.0	COG0682@1|root,COG0682@2|Bacteria,1G0H2@1117|Cyanobacteria,3VIRF@52604|Pleurocapsales	1117|Cyanobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CMS3_k127_1030361_3	555088.DealDRAFT_1127	5.674e-40	160.0	COG0739@1|root,COG0739@2|Bacteria,1V32Q@1239|Firmicutes,251MP@186801|Clostridia	186801|Clostridia	M	Peptidase, M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CMS3_k127_1030361_1	479434.Sthe_0146	2.473e-59	216.0	COG3442@1|root,COG3442@2|Bacteria,2G6KU@200795|Chloroflexi,27XXH@189775|Thermomicrobia	189775|Thermomicrobia	H	CobB/CobQ-like glutamine amidotransferase domain	-	-	-	ko:K07009	-	-	-	-	ko00000	-	-	-	GATase_3
CMS3_k127_1030361_0	1128421.JAGA01000003_gene3528	3.067e-89	312.0	COG0771@1|root,COG0771@2|Bacteria	2|Bacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	3.4.21.10,6.3.2.13,6.3.2.9	ko:K01317,ko:K01925,ko:K01928,ko:K01932	ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100	-	R02783,R02788	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011,ko04131	-	-	-	DUF1727,Mur_ligase_C,Mur_ligase_M
CMS3_k127_1030361_2	298655.KI912267_gene7609	2.726e-40	154.0	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4EUBY@85013|Frankiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_1043253_12	1463858.JOHR01000001_gene6151	9.516e-19	102.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
CMS3_k127_1043253_6	1313172.YM304_07200	8.651e-39	167.0	COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,2I8W5@201174|Actinobacteria	201174|Actinobacteria	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
CMS3_k127_1043253_11	649831.L083_3004	1.14e-22	108.0	COG2267@1|root,COG2267@2|Bacteria,2I94I@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_1043253_4	1146883.BLASA_0805	1.359e-45	175.0	2F7BB@1|root,342EN@2|Bacteria	2|Bacteria	S	F5/8 type C domain	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C
CMS3_k127_1043253_9	118173.KB235914_gene1178	6.958e-29	127.0	COG1985@1|root,COG1985@2|Bacteria	2|Bacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K00082,ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C
CMS3_k127_1043253_3	710421.Mycch_0097	2.44e-54	200.0	COG1011@1|root,COG1011@2|Bacteria,2HHHH@201174|Actinobacteria,2341D@1762|Mycobacteriaceae	201174|Actinobacteria	S	haloacid dehalogenase	dehII	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
CMS3_k127_1043253_14	1121861.KB899910_gene796	2.481e-14	82.0	COG0730@1|root,COG0730@2|Bacteria,1NAFA@1224|Proteobacteria,2UCBB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS3_k127_1043253_8	1123251.ATWM01000006_gene2064	1.291e-33	141.0	COG0491@1|root,COG0491@2|Bacteria,2GMHY@201174|Actinobacteria,4FGA5@85021|Intrasporangiaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	blaB3	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_1043253_5	1040989.AWZU01000011_gene4092	5.117e-43	173.0	COG0665@1|root,COG0665@2|Bacteria,1PEBQ@1224|Proteobacteria,2TRZ6@28211|Alphaproteobacteria,3JRIQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
CMS3_k127_1043253_15	797114.C475_04546	0.0006326	49.0	COG0589@1|root,arCOG03050@2157|Archaea,2XY2I@28890|Euryarchaeota,241FP@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_1043253_13	1265310.CCBD010000061_gene1165	2.826e-16	91.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,2IASU@201174|Actinobacteria,232Z7@1762|Mycobacteriaceae	201174|Actinobacteria	IT	PFAM Adenylate and Guanylate cyclase catalytic domain	lipJ	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
CMS3_k127_1043253_7	562970.Btus_2304	3.386e-36	145.0	COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,4HBPH@91061|Bacilli,27APN@186823|Alicyclobacillaceae	91061|Bacilli	P	TrkA-C domain	ktrA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS3_k127_1043253_2	1347392.CCEZ01000074_gene1908	1.695e-69	254.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,36DPR@31979|Clostridiaceae	186801|Clostridia	P	potassium uptake protein, TrkH family	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS3_k127_1043253_1	1303518.CCALI_00857	9.54e-104	349.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
CMS3_k127_1043253_10	1502851.FG93_03398	7.141e-29	126.0	COG3393@1|root,COG3393@2|Bacteria	2|Bacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,FR47,GNAT_acetyltran
CMS3_k127_1043253_0	383372.Rcas_0560	1.117e-181	584.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2G5ZQ@200795|Chloroflexi,376AA@32061|Chloroflexia	32061|Chloroflexia	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
CMS3_k127_1045833_0	479434.Sthe_3030	3.92e-44	179.0	COG0285@1|root,COG0285@2|Bacteria,2G64M@200795|Chloroflexi,27Y4Y@189775|Thermomicrobia	189775|Thermomicrobia	H	Mur ligase family, glutamate ligase domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
CMS3_k127_1056589_1	479434.Sthe_1109	5.911e-61	230.0	COG0628@1|root,COG0628@2|Bacteria,2G712@200795|Chloroflexi,27Z3Y@189775|Thermomicrobia	189775|Thermomicrobia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CMS3_k127_1056589_5	309801.trd_A0182	6.074e-25	111.0	COG0735@1|root,COG0735@2|Bacteria,2G74Y@200795|Chloroflexi,27YIH@189775|Thermomicrobia	189775|Thermomicrobia	P	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS3_k127_1056589_0	1382356.JQMP01000001_gene1151	5.081e-63	226.0	COG1121@1|root,COG1121@2|Bacteria,2G7X2@200795|Chloroflexi,27XH6@189775|Thermomicrobia	189775|Thermomicrobia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K09820	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
CMS3_k127_1056589_2	479434.Sthe_2975	2.823e-55	206.0	COG1108@1|root,COG1108@2|Bacteria,2G6GH@200795|Chloroflexi,27XKB@189775|Thermomicrobia	189775|Thermomicrobia	P	ABC 3 transport family	-	-	-	ko:K09819	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
CMS3_k127_1056589_7	1435356.Y013_17365	5.708e-09	68.0	COG2050@1|root,COG2050@2|Bacteria,2ISUB@201174|Actinobacteria,4G937@85025|Nocardiaceae	201174|Actinobacteria	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS3_k127_1056589_6	504728.K649_05100	1.229e-21	99.0	COG1733@1|root,COG1733@2|Bacteria,1WJYB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
CMS3_k127_1056589_8	342113.DM82_645	6.521e-07	58.0	COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,2VQFV@28216|Betaproteobacteria,1K7GC@119060|Burkholderiaceae	28216|Betaproteobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
CMS3_k127_1056589_4	309801.trd_1308	4.54e-28	125.0	COG2050@1|root,COG2050@2|Bacteria,2G751@200795|Chloroflexi,27Z8E@189775|Thermomicrobia	189775|Thermomicrobia	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS3_k127_1056589_3	248742.XP_005644623.1	5.23e-45	173.0	2CWGT@1|root,2S4IK@2759|Eukaryota,37ZNN@33090|Viridiplantae,34KHX@3041|Chlorophyta	3041|Chlorophyta	S	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
CMS3_k127_1057509_11	1521187.JPIM01000035_gene3397	1.278e-42	169.0	COG2366@1|root,COG2366@2|Bacteria,2G63N@200795|Chloroflexi,376RD@32061|Chloroflexia	32061|Chloroflexia	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
CMS3_k127_1057509_5	765420.OSCT_2469	1.491e-74	263.0	COG0142@1|root,COG0142@2|Bacteria,2G6BM@200795|Chloroflexi,3755H@32061|Chloroflexia	32061|Chloroflexia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
CMS3_k127_1057509_2	1118054.CAGW01000046_gene1567	7.432e-128	421.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,4H9R3@91061|Bacilli,26R6P@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the phosphoglycerate kinase family	pgk	GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iSB619.SA_RS04145	PGK
CMS3_k127_1057509_1	344747.PM8797T_10544	1.665e-129	424.0	COG3635@1|root,COG3635@2|Bacteria,2IY5S@203682|Planctomycetes	203682|Planctomycetes	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
CMS3_k127_1057509_6	479434.Sthe_1251	9.013e-69	244.0	COG0149@1|root,COG0149@2|Bacteria,2G69W@200795|Chloroflexi,27Y7X@189775|Thermomicrobia	189775|Thermomicrobia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
CMS3_k127_1057509_7	765420.OSCT_0711	4.854e-64	239.0	COG0324@1|root,COG0324@2|Bacteria,2G5S7@200795|Chloroflexi,374TE@32061|Chloroflexia	32061|Chloroflexia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
CMS3_k127_1057509_9	1408322.JHYK01000002_gene1295	4.847e-60	221.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,27IKY@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
CMS3_k127_1057509_19	1279015.KB908457_gene2342	7.451e-05	54.0	COG0454@1|root,COG0456@2|Bacteria,1N5Q1@1224|Proteobacteria,1SCAU@1236|Gammaproteobacteria,1Y5UB@135624|Aeromonadales	135624|Aeromonadales	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_1057509_0	909663.KI867150_gene1212	1.395e-155	501.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42NH6@68525|delta/epsilon subdivisions,2WJCV@28221|Deltaproteobacteria,2MSIE@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	dapL	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_1057509_3	765420.OSCT_2911	6.487e-109	367.0	COG2262@1|root,COG2262@2|Bacteria,2G634@200795|Chloroflexi,375D2@32061|Chloroflexia	32061|Chloroflexia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
CMS3_k127_1057509_13	326427.Cagg_1270	7.447e-40	164.0	COG0655@1|root,COG0655@2|Bacteria,2G9H8@200795|Chloroflexi,37812@32061|Chloroflexia	32061|Chloroflexia	S	NADPH-dependent FMN reductase	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
CMS3_k127_1057509_14	1382306.JNIM01000001_gene2680	5.998e-31	137.0	COG0720@1|root,COG0720@2|Bacteria,2G919@200795|Chloroflexi	200795|Chloroflexi	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
CMS3_k127_1057509_8	1382306.JNIM01000001_gene2603	2.591e-60	219.0	COG1013@1|root,COG1013@2|Bacteria,2G679@200795|Chloroflexi	200795|Chloroflexi	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
CMS3_k127_1057509_4	324602.Caur_0952	4.531e-104	359.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2G69H@200795|Chloroflexi,37507@32061|Chloroflexia	32061|Chloroflexia	C	pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
CMS3_k127_1057509_17	667014.Thein_0080	1.252e-08	59.0	COG1522@1|root,COG1522@2|Bacteria,2GI4U@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
CMS3_k127_1057509_12	357808.RoseRS_3952	1.815e-42	171.0	COG0477@1|root,COG0477@2|Bacteria,2GA6R@200795|Chloroflexi,3782R@32061|Chloroflexia	32061|Chloroflexia	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_1057509_15	257310.BB0670	4.584e-29	128.0	COG2267@1|root,COG2267@2|Bacteria,1NYNM@1224|Proteobacteria,2W3RF@28216|Betaproteobacteria,3T5A2@506|Alcaligenaceae	28216|Betaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
CMS3_k127_1057509_18	1267533.KB906733_gene3076	1.5e-08	60.0	COG3795@1|root,COG3795@2|Bacteria,3Y89G@57723|Acidobacteria,2JNCT@204432|Acidobacteriia	204432|Acidobacteriia	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
CMS3_k127_1057509_16	679926.Mpet_2793	2.876e-12	78.0	arCOG01632@1|root,arCOG01632@2157|Archaea,2XWWZ@28890|Euryarchaeota,2NAN2@224756|Methanomicrobia	224756|Methanomicrobia	Q	PFAM Methyltransferase type	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
CMS3_k127_1057509_10	869210.Marky_1176	1.415e-53	196.0	COG1225@1|root,COG1225@2|Bacteria,1WI9E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
CMS3_k127_1061157_20	219305.MCAG_02356	8.068e-18	91.0	COG1011@1|root,COG1011@2|Bacteria,2HU2R@201174|Actinobacteria,4DAN7@85008|Micromonosporales	201174|Actinobacteria	S	HAD-superfamily hydrolase, subfamily IA	-	-	3.1.3.102,3.1.3.104	ko:K20862	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00548,R07280	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2
CMS3_k127_1061157_14	1120973.AQXL01000123_gene3059	1.436e-31	130.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1UYNA@1239|Firmicutes,4HA9R@91061|Bacilli,278W1@186823|Alicyclobacillaceae	91061|Bacilli	E	Phosphoribosyl-AMP cyclohydrolase	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS14110,iYO844.BSU34860	PRA-CH,PRA-PH
CMS3_k127_1061157_4	1121472.AQWN01000002_gene2276	1.25e-102	350.0	COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,260VM@186807|Peptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05755	His_biosynth
CMS3_k127_1061157_8	765420.OSCT_2842	1.322e-68	244.0	COG0106@1|root,COG0106@2|Bacteria,2G6EC@200795|Chloroflexi,376JE@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CMS3_k127_1061157_9	552811.Dehly_0991	7.21e-67	234.0	COG0118@1|root,COG0118@2|Bacteria,2G6FD@200795|Chloroflexi,34D8Q@301297|Dehalococcoidia	301297|Dehalococcoidia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
CMS3_k127_1061157_1	765420.OSCT_2801	3.456e-198	640.0	COG0272@1|root,COG0272@2|Bacteria,2G5TK@200795|Chloroflexi,3756T@32061|Chloroflexia	32061|Chloroflexia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
CMS3_k127_1061157_3	1128421.JAGA01000001_gene2435	8.833e-108	370.0	COG1814@1|root,COG1814@2|Bacteria,2NPJP@2323|unclassified Bacteria	2|Bacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
CMS3_k127_1061157_2	926550.CLDAP_08170	3.772e-123	404.0	COG1077@1|root,COG1077@2|Bacteria,2G62K@200795|Chloroflexi	200795|Chloroflexi	D	TIGRFAM cell shape determining protein, MreB Mrl family	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
CMS3_k127_1061157_15	443143.GM18_2320	3.459e-30	130.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,42S9I@68525|delta/epsilon subdivisions,2WNTW@28221|Deltaproteobacteria,43TCT@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
CMS3_k127_1061157_5	177437.HRM2_35240	8.152e-92	325.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2MHV4@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Penicillin-binding Protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
CMS3_k127_1061157_10	1122622.ATWJ01000007_gene1911	5.158e-53	202.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4FFT3@85021|Intrasporangiaceae	201174|Actinobacteria	D	Belongs to the SEDS family	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
CMS3_k127_1061157_7	1121033.AUCF01000015_gene1442	2.837e-83	286.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria,2JPY6@204441|Rhodospirillales	204441|Rhodospirillales	L	COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding	-	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
CMS3_k127_1061157_0	552811.Dehly_1200	0.0	1054.0	COG0542@1|root,COG0542@2|Bacteria,2G5RA@200795|Chloroflexi,34CMC@301297|Dehalococcoidia	301297|Dehalococcoidia	O	C-terminal, D2-small domain, of ClpB protein	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
CMS3_k127_1061157_6	926569.ANT_30410	3.327e-84	303.0	COG0539@1|root,COG0539@2|Bacteria,2G656@200795|Chloroflexi	200795|Chloroflexi	J	PFAM RNA binding S1 domain protein	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
CMS3_k127_1061157_11	748671.LCRIS_00064	1.992e-46	168.0	2AU0F@1|root,31JKB@2|Bacteria,1V6XX@1239|Firmicutes,4HWBB@91061|Bacilli	91061|Bacilli	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1061157_16	322098.AYWB_471	1.324e-25	109.0	2B9ZZ@1|root,323DM@2|Bacteria	2|Bacteria	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1061157_12	204536.SULAZ_1633	1.33e-45	171.0	2B9ZZ@1|root,323DM@2|Bacteria	2|Bacteria	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1061157_29	1408823.AXUS01000040_gene1667	0.0006651	43.0	2DQE0@1|root,33689@2|Bacteria,1VH8J@1239|Firmicutes,24WJ6@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1061157_22	243230.DR_2252	8.017e-13	68.0	2ED08@1|root,33H8A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1061157_19	445973.CLOBAR_00537	7.112e-22	97.0	2DX7X@1|root,32V2Y@2|Bacteria,1VB4V@1239|Firmicutes,254XN@186801|Clostridia	186801|Clostridia	S	ORF located using Blastx	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1061157_21	762966.HMPREF9439_01523	1.182e-15	82.0	2DRVE@1|root,33D8G@2|Bacteria,1P1ND@1224|Proteobacteria,2W3YJ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1061157_25	411467.BACCAP_04470	3.569e-05	48.0	2DSV3@1|root,33HII@2|Bacteria,1VQ64@1239|Firmicutes	1239|Firmicutes	S	ORF located using Blastx	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1061157_26	1403948.Q618_VCMC00003G0291	0.0001689	46.0	2EFGV@1|root,3399G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1061157_24	566461.SSFG_05975	7.994e-09	61.0	2E4EA@1|root,3068J@2|Bacteria,2GZWZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1061157_13	1392486.JIAF01000004_gene1438	1.355e-34	136.0	2DMHR@1|root,32RMI@2|Bacteria,4NUR9@976|Bacteroidetes,2FT84@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1061157_23	1122971.BAME01000208_gene6775	2.008e-10	61.0	2DMHR@1|root,32RMI@2|Bacteria,4NUR9@976|Bacteroidetes,2FT84@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1061157_18	498761.HM1_3148	3.197e-22	97.0	2DN97@1|root,32W7A@2|Bacteria,1VANB@1239|Firmicutes,24Q9J@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1061157_17	525367.HMPREF0556_11507	6.511e-25	105.0	2DPM9@1|root,332MQ@2|Bacteria,1VGFB@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1064165_0	1268072.PSAB_04435	3.081e-18	96.0	COG0477@1|root,COG2814@2|Bacteria,1UZKT@1239|Firmicutes,4HDHS@91061|Bacilli,26W8Z@186822|Paenibacillaceae	91061|Bacilli	EGP	Major Facilitator Superfamily	pmrB	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_1064165_1	485913.Krac_0979	1.903e-10	61.0	COG1478@1|root,COG1478@2|Bacteria,2G5TU@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM F420-dependent oxidoreductase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
CMS3_k127_1064878_8	485918.Cpin_6100	1.935e-11	68.0	COG3324@1|root,COG3324@2|Bacteria	2|Bacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
CMS3_k127_1064878_2	1207063.P24_05209	8.856e-178	564.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TU67@28211|Alphaproteobacteria,2JRJM@204441|Rhodospirillales	204441|Rhodospirillales	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS3_k127_1064878_3	861299.J421_0542	6.064e-72	249.0	COG3576@1|root,COG3576@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
CMS3_k127_1064878_9	196162.Noca_0045	3.005e-10	72.0	COG2030@1|root,COG2030@2|Bacteria,2GXE5@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
CMS3_k127_1064878_4	68219.JNXI01000004_gene2564	6.686e-71	258.0	COG1752@1|root,COG1752@2|Bacteria,2I9XW@201174|Actinobacteria	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
CMS3_k127_1064878_6	632292.Calhy_0502	2.217e-62	228.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,24EUD@186801|Clostridia	186801|Clostridia	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS3_k127_1064878_11	1150621.SMUL_2745	1.146e-08	64.0	COG1102@1|root,COG1102@2|Bacteria,1N69V@1224|Proteobacteria,42VW2@68525|delta/epsilon subdivisions,2YQM2@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
CMS3_k127_1064878_10	1211815.CBYP010000069_gene1363	5.276e-10	74.0	COG3087@1|root,COG3087@2|Bacteria,2GNX9@201174|Actinobacteria,4EWGB@85013|Frankiales	201174|Actinobacteria	D	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1064878_5	324602.Caur_2891	5.569e-70	254.0	COG1167@1|root,COG1167@2|Bacteria,2GAK4@200795|Chloroflexi,376KX@32061|Chloroflexia	32061|Chloroflexia	EK	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS3_k127_1064878_0	1121272.KB903249_gene2033	7.374e-234	738.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4DBIN@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter ATPase permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
CMS3_k127_1064878_1	886293.Sinac_1560	9.272e-226	715.0	COG1132@1|root,COG1132@2|Bacteria,2IYCU@203682|Planctomycetes	2|Bacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
CMS3_k127_1064878_12	330214.NIDE1232	8.019e-07	62.0	COG2807@1|root,COG2807@2|Bacteria	2|Bacteria	P	transmembrane transport	lacY	-	-	ko:K02532,ko:K05820,ko:K08167,ko:K08218,ko:K08369	ko01501,map01501	M00628,M00713,M00714	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.1,2.A.1.25,2.A.1.27,2.A.1.3,2.A.1.5	-	-	LacY_symp,MFS_1
CMS3_k127_1064878_7	1122182.KB903836_gene4937	1.936e-23	108.0	COG0703@1|root,COG0703@2|Bacteria,2IHXC@201174|Actinobacteria,4DDCG@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1069404_3	58123.JOFJ01000001_gene2924	7.774e-30	119.0	COG0183@1|root,COG1545@1|root,COG0183@2|Bacteria,COG1545@2|Bacteria,2GKH4@201174|Actinobacteria	201174|Actinobacteria	I	Acetyl-CoA acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1069404_2	1382306.JNIM01000001_gene3012	8.841e-37	147.0	COG1545@1|root,COG1545@2|Bacteria,2G73Z@200795|Chloroflexi	200795|Chloroflexi	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
CMS3_k127_1069404_1	526225.Gobs_1552	7.841e-40	166.0	COG4552@1|root,COG4552@2|Bacteria,2GNXZ@201174|Actinobacteria,4EV9Z@85013|Frankiales	201174|Actinobacteria	S	Sterol carrier protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
CMS3_k127_1069404_0	861299.J421_6032	4.268e-74	259.0	COG3653@1|root,COG3653@2|Bacteria,1ZTAY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
CMS3_k127_1097860_1	1333998.M2A_2493	7.372e-161	513.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,4BTBG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_1097860_3	1282876.BAOK01000002_gene225	5.541e-95	329.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria,4BT8Q@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	Cytochrome P450	pksS	-	1.14.14.1	ko:K00493	ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120	-	R03629,R04121,R05259	RC00046,RC01311	ko00000,ko00001,ko01000	-	-	-	p450
CMS3_k127_1097860_8	1234364.AMSF01000095_gene2618	2.568e-07	62.0	COG4340@1|root,COG4340@2|Bacteria,1R9YQ@1224|Proteobacteria,1RN37@1236|Gammaproteobacteria,1X4WR@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	2OG-Fe_Oxy_2
CMS3_k127_1097860_7	1380394.JADL01000014_gene148	1.759e-27	126.0	COG3971@1|root,COG3971@2|Bacteria,1RA35@1224|Proteobacteria,2VFYX@28211|Alphaproteobacteria,2JSZI@204441|Rhodospirillales	204441|Rhodospirillales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
CMS3_k127_1097860_4	1291050.JAGE01000002_gene3630	7.482e-69	254.0	COG0580@1|root,COG0580@2|Bacteria,1TP4T@1239|Firmicutes,248U5@186801|Clostridia,3WGG8@541000|Ruminococcaceae	186801|Clostridia	G	Major intrinsic protein	-	-	-	ko:K02440	-	-	-	-	ko00000,ko02000	1.A.8.1,1.A.8.2	-	-	MIP
CMS3_k127_1097860_6	1386089.N865_02395	4.537e-42	166.0	COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,4FGNA@85021|Intrasporangiaceae	201174|Actinobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
CMS3_k127_1097860_0	1541065.JRFE01000014_gene1863	6.332e-203	654.0	COG3733@1|root,COG3733@2|Bacteria,1G2YB@1117|Cyanobacteria,3VMF5@52604|Pleurocapsales	1117|Cyanobacteria	Q	Copper amine oxidase, enzyme domain	-	-	1.4.3.21	ko:K00276	ko00260,ko00350,ko00360,ko00410,ko00950,ko00960,ko01100,ko01110,map00260,map00350,map00360,map00410,map00950,map00960,map01100,map01110	-	R02382,R02529,R02613,R03139,R04027,R04300,R06154,R06740	RC00062,RC00189,RC00676,RC01052	ko00000,ko00001,ko01000	-	-	-	Cu_amine_oxid,Cu_amine_oxidN2,Cu_amine_oxidN3
CMS3_k127_1097860_5	1367847.JCM7686_1670	6.245e-43	168.0	COG3393@1|root,COG3393@2|Bacteria,1RAAU@1224|Proteobacteria,2TT9P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	FR47-like protein	MA20_27790	-	-	-	-	-	-	-	-	-	-	-	FR47
CMS3_k127_1097860_2	450851.PHZ_c1133	2.974e-99	336.0	COG2141@1|root,COG2141@2|Bacteria,1PG11@1224|Proteobacteria,2VA1D@28211|Alphaproteobacteria,2KJGK@204458|Caulobacterales	204458|Caulobacterales	C	Luciferase-like monooxygenase	-	-	1.14.13.107	ko:K14733	ko00903,map00903	-	R06398,R09385,R09389,R09393	RC01506	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
CMS3_k127_1106145_5	349741.Amuc_0591	9.517e-06	57.0	COG1266@1|root,COG1266@2|Bacteria,46T6D@74201|Verrucomicrobia,2IUVK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
CMS3_k127_1106145_1	1128421.JAGA01000002_gene1341	2.346e-77	267.0	COG0159@1|root,COG0159@2|Bacteria,2NP9W@2323|unclassified Bacteria	2|Bacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
CMS3_k127_1106145_3	326427.Cagg_2934	2.597e-39	149.0	COG4401@1|root,COG4401@2|Bacteria,2G6VB@200795|Chloroflexi,375RY@32061|Chloroflexia	32061|Chloroflexia	E	PFAM Chorismate mutase of the AroH class	-	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
CMS3_k127_1106145_0	357808.RoseRS_2359	1.353e-126	416.0	COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi,3757M@32061|Chloroflexia	32061|Chloroflexia	E	PFAM DAHP synthetase I KDSA	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
CMS3_k127_1106145_4	926550.CLDAP_29850	2.308e-36	151.0	COG1354@1|root,COG1354@2|Bacteria,2G6WU@200795|Chloroflexi	200795|Chloroflexi	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
CMS3_k127_1106145_2	357808.RoseRS_3756	3.004e-69	245.0	COG0196@1|root,COG0196@2|Bacteria,2G6JF@200795|Chloroflexi,374TG@32061|Chloroflexia	32061|Chloroflexia	H	TIGRFAM riboflavin biosynthesis protein RibF	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
CMS3_k127_1117070_1	1429916.X566_07835	5.365e-20	91.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
CMS3_k127_1117070_0	399795.CtesDRAFT_PD5441	4.398e-159	510.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2VNG0@28216|Betaproteobacteria,4ADU9@80864|Comamonadaceae	28216|Betaproteobacteria	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1150756_1	330214.NIDE0050	1.709e-18	99.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,Ribonuc_L-PSP
CMS3_k127_1150756_0	309801.trd_0718	4.837e-132	431.0	COG2255@1|root,COG2255@2|Bacteria,2G5QQ@200795|Chloroflexi,27Y08@189775|Thermomicrobia	189775|Thermomicrobia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
CMS3_k127_1167508_10	1394178.AWOO02000015_gene7055	9.726e-33	131.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,4EHHR@85012|Streptosporangiales	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_1167508_2	1297865.APJD01000007_gene2359	1.369e-104	350.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TTZZ@28211|Alphaproteobacteria,3JVH5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	MA20_17025	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_1167508_0	1206732.BAGD01000054_gene1961	6.148e-132	433.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4FWX1@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_1167508_3	1033730.CAHG01000002_gene2862	2.026e-95	327.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,4DN5U@85009|Propionibacteriales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
CMS3_k127_1167508_11	1120950.KB892786_gene99	9.536e-26	119.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3,FR47
CMS3_k127_1167508_9	1123024.AUII01000002_gene1084	2.817e-40	164.0	COG2197@1|root,COG2267@1|root,COG2197@2|Bacteria,COG2267@2|Bacteria,2I75H@201174|Actinobacteria	201174|Actinobacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_1167508_8	1123024.AUII01000002_gene1084	9.473e-41	166.0	COG2197@1|root,COG2267@1|root,COG2197@2|Bacteria,COG2267@2|Bacteria,2I75H@201174|Actinobacteria	201174|Actinobacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_1167508_4	1260251.SPISAL_00250	3.722e-93	322.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,1RQ15@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR_6
CMS3_k127_1167508_12	404589.Anae109_3526	3.06e-15	80.0	COG1977@1|root,COG1977@2|Bacteria,1N6RG@1224|Proteobacteria,43BB8@68525|delta/epsilon subdivisions,2X6QE@28221|Deltaproteobacteria,2YVUR@29|Myxococcales	28221|Deltaproteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
CMS3_k127_1167508_5	215803.DB30_0830	3.449e-84	289.0	COG1090@1|root,COG4276@1|root,COG1090@2|Bacteria,COG4276@2|Bacteria,1MUB4@1224|Proteobacteria,42PQ2@68525|delta/epsilon subdivisions,2WK6V@28221|Deltaproteobacteria,2YUBK@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase,Polyketide_cyc
CMS3_k127_1167508_6	1121481.AUAS01000002_gene3195	1.85e-48	179.0	COG4276@1|root,COG4276@2|Bacteria,4NQJG@976|Bacteroidetes,47QN0@768503|Cytophagia	976|Bacteroidetes	S	SRPBCC domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
CMS3_k127_1167508_1	1316936.K678_02905	4.961e-113	372.0	COG0702@1|root,COG0702@2|Bacteria,1PT91@1224|Proteobacteria,2U4IU@28211|Alphaproteobacteria,2JW5D@204441|Rhodospirillales	204441|Rhodospirillales	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
CMS3_k127_1167508_7	1150626.PHAMO_10089	3.896e-42	158.0	COG0702@1|root,COG0702@2|Bacteria,1PT91@1224|Proteobacteria,2U4IU@28211|Alphaproteobacteria,2JW5D@204441|Rhodospirillales	204441|Rhodospirillales	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
CMS3_k127_1169678_13	1125863.JAFN01000001_gene3004	6.818e-32	135.0	COG0340@1|root,COG0340@2|Bacteria,1MWCC@1224|Proteobacteria,42P6I@68525|delta/epsilon subdivisions,2WMAF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
CMS3_k127_1169678_9	243164.DET0846	2.668e-61	226.0	COG0124@1|root,COG0124@2|Bacteria,2G962@200795|Chloroflexi,34CX8@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_His
CMS3_k127_1169678_7	243164.DET0845	5.017e-86	303.0	COG0040@1|root,COG0040@2|Bacteria,2G6DD@200795|Chloroflexi,34CWY@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	-	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
CMS3_k127_1169678_3	479434.Sthe_1676	1.206e-127	423.0	COG0141@1|root,COG0141@2|Bacteria,2G5KP@200795|Chloroflexi,27XKM@189775|Thermomicrobia	189775|Thermomicrobia	C	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
CMS3_k127_1169678_6	383372.Rcas_0200	1.795e-89	308.0	COG0079@1|root,COG0079@2|Bacteria,2G5U4@200795|Chloroflexi,37543@32061|Chloroflexia	32061|Chloroflexia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_1169678_8	1121861.KB899919_gene2798	4.394e-62	222.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2TTVV@28211|Alphaproteobacteria,2JPDI@204441|Rhodospirillales	204441|Rhodospirillales	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
CMS3_k127_1169678_12	1128421.JAGA01000002_gene1394	3.655e-43	164.0	COG2039@1|root,COG2039@2|Bacteria,2NR9V@2323|unclassified Bacteria	2|Bacteria	O	Removes 5-oxoproline from various penultimate amino acid residues except L-proline	pcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:1901564	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
CMS3_k127_1169678_10	298654.FraEuI1c_0789	3.776e-58	213.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4ERCV@85013|Frankiales	201174|Actinobacteria	G	PFAM Inositol monophosphatase	hisN	-	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
CMS3_k127_1169678_16	479434.Sthe_1291	1.437e-21	98.0	COG1828@1|root,COG1828@2|Bacteria,2GBWK@200795|Chloroflexi,27YN2@189775|Thermomicrobia	189775|Thermomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
CMS3_k127_1169678_5	1125863.JAFN01000001_gene301	6.175e-96	324.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	PFAM SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
CMS3_k127_1169678_1	479434.Sthe_1293	2.498e-152	492.0	COG0015@1|root,COG0015@2|Bacteria,2G607@200795|Chloroflexi,27XJC@189775|Thermomicrobia	189775|Thermomicrobia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
CMS3_k127_1169678_17	1120985.AUMI01000011_gene218	1.477e-15	83.0	COG1917@1|root,COG1917@2|Bacteria,1V7FN@1239|Firmicutes,4H6C3@909932|Negativicutes	909932|Negativicutes	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_1169678_11	243164.DET0839	2.685e-44	166.0	COG0041@1|root,COG0041@2|Bacteria,2G6JS@200795|Chloroflexi,34CSG@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
CMS3_k127_1169678_2	562970.Btus_0823	4.086e-129	426.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,4HA70@91061|Bacilli,2797K@186823|Alicyclobacillaceae	91061|Bacilli	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS05245,iYO844.BSU06530	GARS_A,GARS_C,GARS_N
CMS3_k127_1169678_0	552811.Dehly_0662	7.183e-222	704.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2G5WB@200795|Chloroflexi,34CZX@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
CMS3_k127_1169678_4	479434.Sthe_1923	6.937e-123	405.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	DUF3500
CMS3_k127_1169678_14	1382305.AZUC01000056_gene2115	5.137e-28	123.0	COG0009@1|root,COG0009@2|Bacteria,1TP1I@1239|Firmicutes,4HA7W@91061|Bacilli,26DDK@186818|Planococcaceae	91061|Bacilli	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	ywlC	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
CMS3_k127_1169678_15	1121946.AUAX01000004_gene798	2.285e-23	102.0	COG0454@1|root,COG1051@1|root,COG0454@2|Bacteria,COG1051@2|Bacteria,2IFB9@201174|Actinobacteria,4DETN@85008|Micromonosporales	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS3_k127_1171668_0	547163.BN979_04019	6.157e-93	315.0	COG2159@1|root,COG2159@2|Bacteria,2HEB4@201174|Actinobacteria,23EYZ@1762|Mycobacteriaceae	201174|Actinobacteria	S	Amidohydrolase	-	-	4.1.1.45,4.1.1.52	ko:K03392,ko:K22213	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
CMS3_k127_1171668_1	675635.Psed_3729	6.474e-84	290.0	COG1028@1|root,COG1028@2|Bacteria,2GIVT@201174|Actinobacteria,4EAEQ@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.385	ko:K19548	ko01130,map01130	M00787	R10917	RC00154	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
CMS3_k127_1171668_2	1382306.JNIM01000001_gene1934	0.000126	52.0	COG2159@1|root,COG2159@2|Bacteria,2G8DN@200795|Chloroflexi	200795|Chloroflexi	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
CMS3_k127_1175919_15	1120934.KB894404_gene884	1.087e-14	75.0	COG3832@1|root,COG3832@2|Bacteria,2IFGN@201174|Actinobacteria,4E7G8@85010|Pseudonocardiales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_1175919_0	795359.TOPB45_1257	6.258e-171	549.0	COG0174@1|root,COG0174@2|Bacteria,2GH5N@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
CMS3_k127_1175919_17	402881.Plav_1292	1.609e-11	71.0	COG2050@1|root,COG2050@2|Bacteria,1RBET@1224|Proteobacteria,2U5TM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	protein, possibly involved in aromatic compounds catabolism	MA20_42425	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS3_k127_1175919_8	391625.PPSIR1_09715	7.813e-35	148.0	COG3386@1|root,COG3386@2|Bacteria,1P3IB@1224|Proteobacteria,43CN0@68525|delta/epsilon subdivisions,2X7V7@28221|Deltaproteobacteria,2Z22T@29|Myxococcales	28221|Deltaproteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1175919_9	479433.Caci_8396	1.082e-32	136.0	COG3427@1|root,COG3427@2|Bacteria,2ISBF@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
CMS3_k127_1175919_16	1122611.KB903958_gene4086	5.112e-12	74.0	COG2030@1|root,COG2030@2|Bacteria,2IFCJ@201174|Actinobacteria,4EIIF@85012|Streptosporangiales	201174|Actinobacteria	I	MaoC like domain	hadB	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
CMS3_k127_1175919_11	439235.Dalk_3909	1.95e-25	115.0	COG2030@1|root,COG2030@2|Bacteria,1Q5QX@1224|Proteobacteria,431N8@68525|delta/epsilon subdivisions,2WWXI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
CMS3_k127_1175919_7	1385517.N800_12715	4.203e-43	162.0	COG0346@1|root,COG0346@2|Bacteria,1N08M@1224|Proteobacteria,1SE7M@1236|Gammaproteobacteria,1XC6D@135614|Xanthomonadales	135614|Xanthomonadales	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1175919_4	696369.KI912183_gene843	4.473e-89	312.0	COG1007@1|root,COG1007@2|Bacteria,1TR55@1239|Firmicutes,25ED8@186801|Clostridia,25ZY3@186807|Peptococcaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
CMS3_k127_1175919_2	1449126.JQKL01000022_gene110	3.224e-131	435.0	COG1008@1|root,COG1008@2|Bacteria,1UHSH@1239|Firmicutes,24AAH@186801|Clostridia	186801|Clostridia	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342,ko:K05575	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
CMS3_k127_1175919_1	266117.Rxyl_1627	6.902e-141	471.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4CPCM@84995|Rubrobacteria	84995|Rubrobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
CMS3_k127_1175919_13	696281.Desru_1815	3.991e-19	98.0	COG0713@1|root,COG0713@2|Bacteria,1V9Z8@1239|Firmicutes,24NKG@186801|Clostridia,262H1@186807|Peptococcaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
CMS3_k127_1175919_14	1403313.AXBR01000026_gene5204	4.2e-19	96.0	COG0839@1|root,COG0839@2|Bacteria,1V48R@1239|Firmicutes,4HJAV@91061|Bacilli,1ZFW1@1386|Bacillus	91061|Bacilli	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
CMS3_k127_1175919_12	1386089.N865_18435	3.097e-20	98.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria,4FG07@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
CMS3_k127_1175919_5	768704.Desmer_3720	7.335e-85	296.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,25E6Z@186801|Clostridia,260SW@186807|Peptococcaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
CMS3_k127_1175919_3	243164.DET0926	9.772e-107	366.0	COG0649@1|root,COG0649@2|Bacteria,2G5JF@200795|Chloroflexi,34D5Q@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
CMS3_k127_1175919_10	247490.KSU1_D0327	3.342e-26	121.0	COG0852@1|root,COG0852@2|Bacteria,2IZCK@203682|Planctomycetes	203682|Planctomycetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
CMS3_k127_1175919_6	562970.Btus_3230	1.141e-57	205.0	COG0377@1|root,COG0377@2|Bacteria,1TZS1@1239|Firmicutes,4HACH@91061|Bacilli,277Y1@186823|Alicyclobacillaceae	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
CMS3_k127_1175919_18	1216976.AX27061_3726	5.825e-11	64.0	COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,2VVQU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Fe-S assembly protein IscX	iscX	-	-	-	-	-	-	-	-	-	-	-	Fe-S_assembly
CMS3_k127_1178168_5	1386089.N865_18970	1.624e-06	53.0	COG0346@1|root,COG0346@2|Bacteria,2IPGW@201174|Actinobacteria,4FH0K@85021|Intrasporangiaceae	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
CMS3_k127_1178168_3	1122604.JONR01000003_gene1384	3.372e-24	108.0	COG1846@1|root,COG1846@2|Bacteria,1NIQA@1224|Proteobacteria,1SSAQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
CMS3_k127_1178168_1	751944.HALDL1_01735	1.411e-24	119.0	COG0477@1|root,arCOG00132@2157|Archaea,2XVCP@28890|Euryarchaeota,23UPN@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_1178168_0	479434.Sthe_2035	3.597e-41	162.0	COG1651@1|root,COG1651@2|Bacteria,2G8TG@200795|Chloroflexi,27YB4@189775|Thermomicrobia	189775|Thermomicrobia	O	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
CMS3_k127_1178168_2	525904.Tter_1734	2.53e-24	108.0	COG4243@1|root,COG4243@2|Bacteria	2|Bacteria	S	quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4,VKOR
CMS3_k127_1178168_4	1380347.JNII01000007_gene711	5.181e-15	85.0	COG1102@1|root,COG1102@2|Bacteria,2I8J3@201174|Actinobacteria,4EWDV@85013|Frankiales	201174|Actinobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
CMS3_k127_1178168_6	1347369.CCAD010000018_gene1470	0.0006047	49.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,1ZDDG@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
CMS3_k127_1190544_0	479434.Sthe_0156	1.067e-60	228.0	COG3850@1|root,COG3850@2|Bacteria,2GBH4@200795|Chloroflexi,27XF0@189775|Thermomicrobia	189775|Thermomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
CMS3_k127_1190544_1	709986.Deima_0441	1.227e-53	207.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c,HisKA_3
CMS3_k127_1190544_2	1245475.ANAE01000082_gene1907	3.898e-41	168.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4EIFM@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
CMS3_k127_1190544_3	717785.HYPMC_0871	4.041e-35	141.0	COG4263@1|root,COG4263@2|Bacteria	2|Bacteria	C	nitrous-oxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
CMS3_k127_1252402_21	7955.ENSDARP00000064280	3.899e-06	48.0	KOG0589@1|root,KOG0589@2759|Eukaryota,38C6Q@33154|Opisthokonta,3BE0Z@33208|Metazoa,3CSVT@33213|Bilateria,481GJ@7711|Chordata,491A6@7742|Vertebrata,49XQ6@7898|Actinopterygii	33208|Metazoa	T	NIMA (never in mitosis gene a)-related kinase 1	nekl-2	GO:0008150,GO:0030100,GO:0032501,GO:0032879,GO:0042303,GO:0045807,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051049,GO:0051050,GO:0051128,GO:0051130,GO:0060627,GO:0065007	2.7.11.1	ko:K08857,ko:K20877	-	-	-	-	ko00000,ko01000,ko01001,ko03036,ko03400	-	-	-	Pkinase
CMS3_k127_1252402_12	234267.Acid_5780	7.224e-26	118.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,TPR_8,Trans_reg_C
CMS3_k127_1252402_7	720554.Clocl_3574	1.749e-47	184.0	COG2159@1|root,COG2159@2|Bacteria,1US2K@1239|Firmicutes,25A0W@186801|Clostridia,3WR01@541000|Ruminococcaceae	186801|Clostridia	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
CMS3_k127_1252402_19	932213.SPM24T3_15751	3.741e-07	62.0	COG5628@1|root,COG5628@2|Bacteria,1NHRZ@1224|Proteobacteria,1SYQ7@1236|Gammaproteobacteria,4042W@613|Serratia	1236|Gammaproteobacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_1252402_16	479434.Sthe_3505	1.916e-14	88.0	COG1011@1|root,COG1011@2|Bacteria,2G78N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CMS3_k127_1252402_0	867845.KI911784_gene2680	7.718e-282	906.0	COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi,375DR@32061|Chloroflexia	32061|Chloroflexia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
CMS3_k127_1252402_8	330214.NIDE0783	3.425e-38	153.0	COG0193@1|root,COG0193@2|Bacteria,3J0QR@40117|Nitrospirae	40117|Nitrospirae	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
CMS3_k127_1252402_5	1128421.JAGA01000002_gene371	2.07e-63	229.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
CMS3_k127_1252402_4	439235.Dalk_5191	4.268e-65	242.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42NTV@68525|delta/epsilon subdivisions,2WJTP@28221|Deltaproteobacteria,2MIWR@213118|Desulfobacterales	1224|Proteobacteria	C	PFAM CoA-binding domain protein	MA20_15065	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
CMS3_k127_1252402_1	1128421.JAGA01000002_gene997	1.39e-123	408.0	COG1104@1|root,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS3_k127_1252402_6	479434.Sthe_3029	3.245e-49	194.0	COG0461@1|root,COG0461@2|Bacteria,2G7HB@200795|Chloroflexi,27XKH@189775|Thermomicrobia	189775|Thermomicrobia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
CMS3_k127_1252402_2	644966.Tmar_0227	1.308e-101	342.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia,3WD1G@538999|Clostridiales incertae sedis	186801|Clostridia	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81	ko:K00015,ko:K00090	ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R00717,R01388,R01392,R01739	RC00031,RC00042,RC00084	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS3_k127_1252402_22	44251.PDUR_13285	9.355e-05	52.0	COG2318@1|root,COG2318@2|Bacteria,1V2BI@1239|Firmicutes,4HF8B@91061|Bacilli,26XPE@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the metal hydrolase YfiT family	yfiT	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS3_k127_1252402_9	13689.BV96_03430	1.42e-34	145.0	COG0237@1|root,COG2410@1|root,COG3359@1|root,COG0237@2|Bacteria,COG2410@2|Bacteria,COG3359@2|Bacteria,1PMKU@1224|Proteobacteria,2UQQH@28211|Alphaproteobacteria,2KA1A@204457|Sphingomonadales	204457|Sphingomonadales	H	Protein of unknown function (DUF429)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1252402_15	671143.DAMO_1510	7.071e-18	87.0	COG0607@1|root,COG0607@2|Bacteria,2NRI8@2323|unclassified Bacteria	2|Bacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CMS3_k127_1252402_18	1521187.JPIM01000051_gene3470	2.375e-08	66.0	COG0745@1|root,COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,PAS_4,Response_reg
CMS3_k127_1252402_10	1128421.JAGA01000002_gene1544	7.199e-29	124.0	COG2802@1|root,COG2802@2|Bacteria,2NPRK@2323|unclassified Bacteria	2|Bacteria	S	ATP-dependent protease La (LON) substrate-binding domain	lonD	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
CMS3_k127_1252402_3	1110502.TMO_1021	1.886e-75	284.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria,2JQ15@204441|Rhodospirillales	204441|Rhodospirillales	C	Formate dehydrogenase subunit alpha	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
CMS3_k127_1252402_14	1193729.A1OE_595	1.128e-22	107.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2TRFE@28211|Alphaproteobacteria,2JPHK@204441|Rhodospirillales	204441|Rhodospirillales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
CMS3_k127_1252402_17	189753.AXAS01000003_gene4726	2.283e-13	80.0	COG1234@1|root,COG1234@2|Bacteria,1Q4PW@1224|Proteobacteria,2TUHQ@28211|Alphaproteobacteria,3JTWA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	MA20_22080	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CMS3_k127_1252402_13	1160718.SU9_03276	6.824e-24	109.0	COG2068@1|root,COG2068@2|Bacteria,2GK5R@201174|Actinobacteria	201174|Actinobacteria	NU	MobA-related protein	nboR	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS3_k127_1252402_11	1121441.AUCX01000009_gene2552	3.566e-28	119.0	COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria,2M82B@213115|Desulfovibrionales	28221|Deltaproteobacteria	CO	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	nifU	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
CMS3_k127_1252402_20	272134.KB731324_gene5610	7.13e-07	53.0	COG1225@1|root,COG1225@2|Bacteria,1G55Y@1117|Cyanobacteria,1HB1H@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM AhpC TSA family	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
CMS3_k127_1293595_1	1121957.ATVL01000007_gene1871	1.745e-30	125.0	COG0801@1|root,COG0801@2|Bacteria,4NGE8@976|Bacteroidetes,47QG8@768503|Cytophagia	976|Bacteroidetes	H	TIGRFAM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK,dNK
CMS3_k127_1293595_0	1382356.JQMP01000003_gene1503	7.274e-83	285.0	COG0294@1|root,COG0294@2|Bacteria,2G6A6@200795|Chloroflexi,27XJT@189775|Thermomicrobia	189775|Thermomicrobia	H	Pterin binding enzyme	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CMS3_k127_1293595_3	1249975.JQLP01000003_gene76	0.0001028	54.0	COG1361@1|root,COG3266@1|root,COG4932@1|root,COG1361@2|Bacteria,COG3266@2|Bacteria,COG4932@2|Bacteria,4NMB8@976|Bacteroidetes,1HZAG@117743|Flavobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
CMS3_k127_1293595_2	1004149.AFOE01000020_gene3123	9.629e-07	57.0	COG1404@1|root,COG4386@1|root,COG1404@2|Bacteria,COG4386@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	bhp	-	-	ko:K13735,ko:K20276,ko:K21449	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001,ko02000	1.B.40.2	-	-	B_lectin,CHU_C,Calx-beta
CMS3_k127_129707_0	1287276.X752_25710	3.195e-137	454.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TVTA@28211|Alphaproteobacteria,43JR3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.109	ko:K19715	-	-	R11395	RC00160	ko00000,ko01000,ko01005	-	-	-	DegT_DnrJ_EryC1
CMS3_k127_129707_1	1380391.JIAS01000013_gene3588	5.56e-40	167.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,2TQM1@28211|Alphaproteobacteria,2JVE5@204441|Rhodospirillales	204441|Rhodospirillales	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_1301554_1	1211817.CCAT010000039_gene14	2.019e-33	136.0	COG0500@1|root,COG2226@2|Bacteria,1UJDM@1239|Firmicutes,24D7B@186801|Clostridia,36F5U@31979|Clostridiaceae	186801|Clostridia	Q	Methyltransferase type	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_1301554_0	255470.cbdbA1727	2.347e-198	638.0	COG1032@1|root,COG1032@2|Bacteria,2G5N0@200795|Chloroflexi,34CUW@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS3_k127_1301554_2	1121926.AXWO01000027_gene371	1.098e-28	132.0	2EH2B@1|root,33AU9@2|Bacteria,2H930@201174|Actinobacteria	201174|Actinobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CMS3_k127_1321200_0	9031.ENSGALP00000026689	1.34e-115	385.0	COG0596@1|root,COG1011@1|root,KOG3085@2759|Eukaryota,KOG4178@2759|Eukaryota,39WAD@33154|Opisthokonta,3BACN@33208|Metazoa,3CVBC@33213|Bilateria,482KF@7711|Chordata,48X7C@7742|Vertebrata,4GKMZ@8782|Aves	33208|Metazoa	I	Epoxide hydrolase 2	EPHX2	GO:0000287,GO:0001676,GO:0002532,GO:0002538,GO:0002539,GO:0003008,GO:0003013,GO:0003018,GO:0003674,GO:0003824,GO:0004301,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006633,GO:0006690,GO:0006725,GO:0006793,GO:0006796,GO:0006805,GO:0006810,GO:0006873,GO:0006874,GO:0006875,GO:0006886,GO:0006950,GO:0006952,GO:0006954,GO:0006996,GO:0007031,GO:0007600,GO:0008015,GO:0008104,GO:0008150,GO:0008152,GO:0008217,GO:0008610,GO:0009056,GO:0009058,GO:0009410,GO:0009636,GO:0009810,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0015031,GO:0015643,GO:0015833,GO:0016043,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016801,GO:0016803,GO:0017144,GO:0018904,GO:0019216,GO:0019218,GO:0019222,GO:0019233,GO:0019369,GO:0019373,GO:0019439,GO:0019725,GO:0019752,GO:0030003,GO:0030258,GO:0031907,GO:0031974,GO:0032501,GO:0032787,GO:0033036,GO:0033365,GO:0033559,GO:0034613,GO:0035150,GO:0035296,GO:0042221,GO:0042577,GO:0042578,GO:0042579,GO:0042592,GO:0042632,GO:0042759,GO:0042802,GO:0042803,GO:0042886,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043651,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0045777,GO:0046272,GO:0046394,GO:0046483,GO:0046839,GO:0046872,GO:0046907,GO:0046983,GO:0048518,GO:0048878,GO:0050789,GO:0050801,GO:0050877,GO:0050880,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055088,GO:0055092,GO:0060255,GO:0062012,GO:0065007,GO:0065008,GO:0070013,GO:0070727,GO:0070887,GO:0071466,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072330,GO:0072503,GO:0072507,GO:0072593,GO:0072594,GO:0072662,GO:0072663,GO:0080090,GO:0090066,GO:0090181,GO:0097176,GO:0097746,GO:0097755,GO:0098771,GO:1900673,GO:1901360,GO:1901361,GO:1901568,GO:1901575,GO:1901576	3.1.3.76,3.3.2.10	ko:K08726,ko:K10089	ko00590,ko00625,ko01100,ko01120,ko04142,ko04145,ko04146,map00590,map00625,map01100,map01120,map04142,map04145,map04146	-	R05842,R07108,R07109,R07110,R07111	RC01477,RC01757	ko00000,ko00001,ko01000,ko01002,ko01009,ko04091,ko04147	-	-	-	Abhydrolase_1,HAD_2
CMS3_k127_1321200_8	1158608.I583_01204	1.321e-18	89.0	COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,4HKF2@91061|Bacilli,4B30R@81852|Enterococcaceae	91061|Bacilli	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS3_k127_1321200_3	392499.Swit_0205	2.343e-37	148.0	COG0662@1|root,COG0662@2|Bacteria,1N71F@1224|Proteobacteria,2UFSH@28211|Alphaproteobacteria,2KBHV@204457|Sphingomonadales	204457|Sphingomonadales	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_1321200_1	1280952.HJA_01920	3.121e-42	158.0	COG4308@1|root,COG4308@2|Bacteria,1RJ3T@1224|Proteobacteria,2UAH6@28211|Alphaproteobacteria,440IB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	Limonene-1,2-epoxide hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	LEH
CMS3_k127_1321200_9	357808.RoseRS_3658	3.545e-16	87.0	COG0745@1|root,COG1716@1|root,COG0745@2|Bacteria,COG1716@2|Bacteria,2G8VB@200795|Chloroflexi,375FX@32061|Chloroflexia	32061|Chloroflexia	K	transcriptional regulator domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Trans_reg_C
CMS3_k127_1321200_2	1121926.AXWO01000019_gene1915	3.376e-38	167.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS3_k127_1321200_5	1163408.UU9_04422	1.456e-27	122.0	COG3832@1|root,COG3832@2|Bacteria,1PH86@1224|Proteobacteria,1T8WT@1236|Gammaproteobacteria,1XBC8@135614|Xanthomonadales	135614|Xanthomonadales	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_1321200_4	1385518.N798_06590	7.999e-30	121.0	COG0640@1|root,COG0640@2|Bacteria,2IKQY@201174|Actinobacteria,4FHDK@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
CMS3_k127_1321200_7	1158292.JPOE01000005_gene891	1.869e-21	108.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2VH3E@28216|Betaproteobacteria,1KIUH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_1321200_6	105420.BBPO01000014_gene6045	2.178e-22	105.0	COG3832@1|root,COG3832@2|Bacteria,2IFGN@201174|Actinobacteria,2NIUF@228398|Streptacidiphilus	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_1321200_10	1313172.YM304_11870	4.32e-12	70.0	COG3832@1|root,COG3832@2|Bacteria,2IFGN@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_1321328_3	1540221.JQNI01000004_gene229	3.447e-44	167.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rfaG3	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_1321328_5	420662.Mpe_A1378	2.367e-12	81.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,CW_binding_2,Lipase_GDSL,Lipase_GDSL_2,VCBS
CMS3_k127_1321328_4	1144310.PMI07_004708	1.647e-40	162.0	COG2267@1|root,COG2267@2|Bacteria,1N9CI@1224|Proteobacteria,2UG67@28211|Alphaproteobacteria,4BDEJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_1321328_1	1382306.JNIM01000001_gene57	5.334e-67	254.0	COG2141@1|root,COG2141@2|Bacteria,2G99A@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_1321328_0	1254432.SCE1572_47340	6.063e-138	450.0	COG0520@1|root,COG0520@2|Bacteria,1MXH1@1224|Proteobacteria,43203@68525|delta/epsilon subdivisions,2WWMI@28221|Deltaproteobacteria,2YTY1@29|Myxococcales	28221|Deltaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	cefD	-	5.1.1.17	ko:K04127	ko00311,ko01100,ko01130,map00311,map01100,map01130	M00673	R04147	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
CMS3_k127_1321328_2	1382356.JQMP01000003_gene1673	1.463e-62	228.0	COG2141@1|root,COG2141@2|Bacteria,2G869@200795|Chloroflexi,27XFF@189775|Thermomicrobia	189775|Thermomicrobia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_133435_0	2074.JNYD01000015_gene4604	1.047e-24	105.0	COG3848@1|root,COG3848@2|Bacteria,2H2J1@201174|Actinobacteria	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
CMS3_k127_133435_1	446462.Amir_3508	3.356e-07	63.0	COG0834@1|root,COG0834@2|Bacteria,2GJH8@201174|Actinobacteria,4DYY6@85010|Pseudonocardiales	201174|Actinobacteria	ET	Periplasmic component of amino acid ABC-type transporter signal transduction system	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
CMS3_k127_1383652_1	123899.JPQP01000023_gene2875	6.057e-49	184.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2VJ3D@28216|Betaproteobacteria,3T3B1@506|Alcaligenaceae	28216|Betaproteobacteria	Q	N-acyl-D-aspartate D-glutamate deacylase	dan	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
CMS3_k127_1383652_0	479434.Sthe_0784	9.243e-107	354.0	COG0498@1|root,COG0498@2|Bacteria,2G5RK@200795|Chloroflexi,27Y4R@189775|Thermomicrobia	189775|Thermomicrobia	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_1386488_0	114615.BRADO5602	1.782e-32	142.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,2U07Z@28211|Alphaproteobacteria,3JR8H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_1413154_4	1128421.JAGA01000002_gene979	2.014e-33	134.0	2DMUR@1|root,32TTD@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4395)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395
CMS3_k127_1413154_2	479434.Sthe_0899	2.109e-74	260.0	COG3872@1|root,COG3872@2|Bacteria,2G5XQ@200795|Chloroflexi,27XQ4@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function (DUF1385)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
CMS3_k127_1413154_6	411471.SUBVAR_05136	2.596e-27	114.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,3WKI1@541000|Ruminococcaceae	186801|Clostridia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
CMS3_k127_1413154_5	292415.Tbd_0865	8.519e-32	126.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2VU4W@28216|Betaproteobacteria,1KTAS@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Ribosomal L27 protein	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
CMS3_k127_1413154_7	926550.CLDAP_20650	1.412e-26	113.0	COG0261@1|root,COG0261@2|Bacteria,2G72T@200795|Chloroflexi	200795|Chloroflexi	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
CMS3_k127_1413154_11	573.JG24_17205	3.906e-08	64.0	COG0586@1|root,COG0586@2|Bacteria,1R5SJ@1224|Proteobacteria,1S274@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	yohD	GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0032505,GO:0043093,GO:0044464,GO:0051301,GO:0071944	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS3_k127_1413154_0	1382306.JNIM01000001_gene1179	1.391e-224	713.0	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi	200795|Chloroflexi	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
CMS3_k127_1413154_9	1382306.JNIM01000001_gene1662	8.228e-09	59.0	COG1942@1|root,COG1942@2|Bacteria	2|Bacteria	S	isomerase activity	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
CMS3_k127_1413154_3	240302.BN982_02059	1.976e-49	184.0	COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,4HB7M@91061|Bacilli,3ND22@45667|Halobacillus	91061|Bacilli	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
CMS3_k127_1413154_8	1283299.AUKG01000002_gene4755	2.871e-22	101.0	COG0792@1|root,COG0792@2|Bacteria,2HP2Y@201174|Actinobacteria,4CQE0@84995|Rubrobacteria	84995|Rubrobacteria	L	Uncharacterised protein family UPF0102	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
CMS3_k127_1413154_10	479434.Sthe_1281	1.294e-08	62.0	COG2331@1|root,COG2331@2|Bacteria,2G795@200795|Chloroflexi,27YPR@189775|Thermomicrobia	189775|Thermomicrobia	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
CMS3_k127_1413154_1	555088.DealDRAFT_1177	1.751e-206	662.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,42KC8@68298|Syntrophomonadaceae	186801|Clostridia	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
CMS3_k127_1432275_1	1041146.ATZB01000029_gene5428	1.759e-29	126.0	COG0500@1|root,COG2226@2|Bacteria,1RD2T@1224|Proteobacteria,2VBBK@28211|Alphaproteobacteria,4BJ74@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_1432275_2	1205680.CAKO01000038_gene1561	4.482e-13	76.0	COG1917@1|root,COG1917@2|Bacteria,1RKFY@1224|Proteobacteria,2UBGT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1432275_0	530564.Psta_0870	1.906e-180	609.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,2IX0I@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh
CMS3_k127_1432275_3	1117319.PSPO_18596	3.202e-09	60.0	COG1917@1|root,COG1917@2|Bacteria,1N3SE@1224|Proteobacteria,1SA7D@1236|Gammaproteobacteria,2Q3HM@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1432275_4	1449069.JMLO01000025_gene2371	4.136e-06	57.0	COG0454@1|root,COG0456@2|Bacteria,2I5JN@201174|Actinobacteria,4G0ZP@85025|Nocardiaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_1436418_1	671143.DAMO_1028	8.913e-116	380.0	COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113,2.5.1.47,6.1.1.16	ko:K01883,ko:K12339,ko:K21148	ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230,map04122	M00021,M00359,M00360	R00897,R03132,R03601,R03650,R04859,R10610	RC00020,RC00055,RC00523,RC02814,RC02821,RC02876,RC03225	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	PALP,tRNA-synt_1e
CMS3_k127_1436418_4	1123024.AUII01000005_gene2291	1.748e-15	81.0	COG0789@1|root,COG0789@2|Bacteria,2INKP@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1
CMS3_k127_1436418_3	547144.HydHO_0121	1.041e-24	109.0	COG1977@1|root,COG1977@2|Bacteria,2G563@200783|Aquificae	200783|Aquificae	H	TIGRFAM MoaD family protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
CMS3_k127_1436418_0	525904.Tter_1313	3.291e-131	430.0	COG0476@1|root,COG1977@1|root,COG0476@2|Bacteria,COG1977@2|Bacteria,2NPX3@2323|unclassified Bacteria	2|Bacteria	H	ThiF family	moeB	-	2.7.7.73,2.7.7.80,2.8.1.11	ko:K03148,ko:K03636,ko:K21029,ko:K21147	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
CMS3_k127_1436418_2	269799.Gmet_2988	4.824e-114	375.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,43S9J@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysK-1	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_1436418_5	1382304.JNIL01000001_gene3223	4.456e-05	48.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,4HX1U@91061|Bacilli,27A4H@186823|Alicyclobacillaceae	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS3_k127_153324_1	861299.J421_0662	7.303e-31	124.0	COG2030@1|root,COG2030@2|Bacteria	2|Bacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
CMS3_k127_153324_2	1150398.JIBJ01000003_gene1496	2.364e-07	63.0	2AU69@1|root,31JT7@2|Bacteria,2IFP7@201174|Actinobacteria,1WBGW@1268|Micrococcaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_153324_0	1280941.HY2_04785	2.151e-67	238.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TS6G@28211|Alphaproteobacteria,43W8V@69657|Hyphomonadaceae	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_15974_2	1397666.RS24_00313	1.318e-11	67.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2TVJ9@28211|Alphaproteobacteria,4BT9Y@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_15974_0	383372.Rcas_3001	1.148e-67	247.0	COG1167@1|root,COG1167@2|Bacteria,2G81Z@200795|Chloroflexi,376VD@32061|Chloroflexia	32061|Chloroflexia	EK	PFAM aminotransferase, class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS3_k127_15974_1	485913.Krac_4919	1.346e-13	79.0	2EMNF@1|root,33FAU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1605568_2	324602.Caur_1751	2.779e-42	171.0	COG0547@1|root,COG0547@2|Bacteria,2G5YV@200795|Chloroflexi,375B9@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
CMS3_k127_1605568_1	479434.Sthe_1877	1.166e-74	262.0	COG0512@1|root,COG0512@2|Bacteria,2G69G@200795|Chloroflexi,27Y8S@189775|Thermomicrobia	189775|Thermomicrobia	EH	Peptidase C26	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
CMS3_k127_1605568_5	316274.Haur_4719	9.057e-05	54.0	COG1011@1|root,COG1011@2|Bacteria,2G74Q@200795|Chloroflexi	200795|Chloroflexi	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS3_k127_1605568_4	1408419.JHYG01000007_gene2969	2.914e-05	55.0	COG0494@1|root,COG1670@1|root,COG0494@2|Bacteria,COG1670@2|Bacteria,1RCZM@1224|Proteobacteria,2U7A4@28211|Alphaproteobacteria,2JS44@204441|Rhodospirillales	204441|Rhodospirillales	JL	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Acetyltransf_3,NUDIX,NUDIX_4
CMS3_k127_1605568_0	255470.cbdbA1441	3.62e-165	533.0	COG0147@1|root,COG0147@2|Bacteria,2G5M7@200795|Chloroflexi,34CJD@301297|Dehalococcoidia	301297|Dehalococcoidia	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
CMS3_k127_1605568_3	685727.REQ_07080	1.858e-09	61.0	COG0596@1|root,COG2197@1|root,COG0596@2|Bacteria,COG2197@2|Bacteria,2GN4Z@201174|Actinobacteria,4FW5A@85025|Nocardiaceae	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,GerE
CMS3_k127_163238_0	1123023.JIAI01000001_gene7295	3.847e-158	520.0	COG0028@1|root,COG0028@2|Bacteria,2H36Z@201174|Actinobacteria	201174|Actinobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_163238_2	1415780.JPOG01000001_gene2733	4.17e-63	235.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,1RQ15@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR_6
CMS3_k127_163238_7	1110697.NCAST_21_00780	3.853e-05	52.0	COG0425@1|root,COG0425@2|Bacteria,2GSNH@201174|Actinobacteria	201174|Actinobacteria	O	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
CMS3_k127_163238_1	471852.Tcur_0026	1.284e-122	406.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4EGT2@85012|Streptosporangiales	201174|Actinobacteria	S	SMART CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
CMS3_k127_163238_5	1137271.AZUM01000002_gene2763	2.581e-12	75.0	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria,4E426@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
CMS3_k127_163238_3	749927.AMED_4721	1.573e-26	113.0	COG3832@1|root,COG3832@2|Bacteria,2IFGN@201174|Actinobacteria,4E7G8@85010|Pseudonocardiales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_163238_4	1123248.KB893327_gene770	5.451e-25	111.0	COG3832@1|root,COG3832@2|Bacteria,4NQXU@976|Bacteroidetes,1IXTD@117747|Sphingobacteriia	976|Bacteroidetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_163238_6	43759.JNWK01000016_gene259	4.842e-09	61.0	COG3832@1|root,COG3832@2|Bacteria,2IFGN@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_1695728_3	1110502.TMO_0664	1.311e-73	254.0	COG1638@1|root,COG1638@2|Bacteria,1P3MK@1224|Proteobacteria,2TVQB@28211|Alphaproteobacteria,2JQ37@204441|Rhodospirillales	204441|Rhodospirillales	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
CMS3_k127_1695728_4	1121033.AUCF01000017_gene3777	7.941e-35	139.0	COG3090@1|root,COG3090@2|Bacteria,1N7J6@1224|Proteobacteria,2UDKU@28211|Alphaproteobacteria,2JTRZ@204441|Rhodospirillales	204441|Rhodospirillales	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
CMS3_k127_1695728_0	1110502.TMO_0666	1.472e-180	573.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JPUA@204441|Rhodospirillales	204441|Rhodospirillales	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
CMS3_k127_1695728_1	316067.Geob_3329	9.195e-149	484.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,42MCZ@68525|delta/epsilon subdivisions,2WJED@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	TIGRFAM type I secretion membrane fusion protein, HlyD	-	-	-	ko:K02022,ko:K11003	ko03070,ko05133,map03070,map05133	M00325,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	8.A.1.3.1,8.A.1.3.2	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
CMS3_k127_1695728_2	1441629.PCH70_47820	3.95e-125	440.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1Z902@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	Q	Haemolysin-type calcium binding protein related domain	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HCBP_related,HemolysinCabind
CMS3_k127_17032_6	525904.Tter_0348	1.11e-31	135.0	COG1321@1|root,COG1321@2|Bacteria,2NRDQ@2323|unclassified Bacteria	2|Bacteria	K	FeoA	ideR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356,ko:K03709	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03000,ko03400	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
CMS3_k127_17032_0	1382356.JQMP01000001_gene875	3.133e-105	351.0	COG2141@1|root,COG2141@2|Bacteria,2G5MF@200795|Chloroflexi,27Z35@189775|Thermomicrobia	189775|Thermomicrobia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_17032_5	1142394.PSMK_09230	6.274e-46	181.0	COG1363@1|root,COG1363@2|Bacteria	2|Bacteria	G	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28,Peptidase_M42
CMS3_k127_17032_1	309801.trd_0216	4.524e-102	348.0	COG2265@1|root,COG2265@2|Bacteria,2G6IV@200795|Chloroflexi,27XG5@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
CMS3_k127_17032_4	479434.Sthe_2681	1.663e-48	180.0	COG0424@1|root,COG0424@2|Bacteria,2G6U2@200795|Chloroflexi,27YA3@189775|Thermomicrobia	189775|Thermomicrobia	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
CMS3_k127_17032_3	390989.JOEG01000001_gene5001	8.646e-63	231.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria,4DEE4@85008|Micromonosporales	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
CMS3_k127_17032_7	1121033.AUCF01000033_gene3628	1.803e-25	110.0	COG1695@1|root,COG1695@2|Bacteria,1N0PH@1224|Proteobacteria,2UBD4@28211|Alphaproteobacteria,2JT64@204441|Rhodospirillales	204441|Rhodospirillales	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
CMS3_k127_17032_8	1408424.JHYI01000013_gene1008	3.552e-11	71.0	COG4758@1|root,COG4758@2|Bacteria,1V9PN@1239|Firmicutes,4HMCU@91061|Bacilli,1ZQ0N@1386|Bacillus	91061|Bacilli	S	Cell wall-active antibiotics response 4TMS YvqF	-	-	-	ko:K11622	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	DUF2154
CMS3_k127_17032_10	1185876.BN8_01476	0.0003824	50.0	COG1983@1|root,COG1983@2|Bacteria,4NRBJ@976|Bacteroidetes,47QNK@768503|Cytophagia	976|Bacteroidetes	KT	Phage shock protein C, PspC	-	-	-	-	-	-	-	-	-	-	-	-	PspC
CMS3_k127_17032_2	479434.Sthe_1775	7.554e-97	323.0	COG1136@1|root,COG1136@2|Bacteria,2G6B5@200795|Chloroflexi,27YCE@189775|Thermomicrobia	189775|Thermomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_17032_9	479434.Sthe_1776	1.43e-07	62.0	COG0577@1|root,COG3127@1|root,COG0577@2|Bacteria,COG3127@2|Bacteria,2G6CK@200795|Chloroflexi,27Z42@189775|Thermomicrobia	189775|Thermomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
CMS3_k127_1708243_0	1502851.FG93_02661	6.028e-25	114.0	COG0778@1|root,COG0778@2|Bacteria,1MY39@1224|Proteobacteria,2TTZC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0778 Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS3_k127_1708243_2	880070.Cycma_0982	1.958e-05	57.0	COG0265@1|root,COG0265@2|Bacteria,4P0IB@976|Bacteroidetes,47UD8@768503|Cytophagia	976|Bacteroidetes	O	PDZ domain (Also known as DHR or GLGF)	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_1708243_1	551275.KB899544_gene1255	2.884e-08	63.0	COG1595@1|root,COG1595@2|Bacteria,1RIU9@1224|Proteobacteria,2UF2N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1736864_5	311424.DhcVS_328	7.445e-33	129.0	COG0516@1|root,COG0516@2|Bacteria,2G5ZX@200795|Chloroflexi,34CRY@301297|Dehalococcoidia	301297|Dehalococcoidia	C	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
CMS3_k127_1736864_6	317619.ANKN01000106_gene3621	2.066e-24	116.0	COG2720@1|root,COG2720@2|Bacteria,1G72A@1117|Cyanobacteria,1MN74@1212|Prochloraceae	1117|Cyanobacteria	V	VanW like protein	-	-	-	ko:K18346	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01504	-	-	-	VanW
CMS3_k127_1736864_4	867845.KI911784_gene1785	2.366e-48	189.0	COG2890@1|root,COG2890@2|Bacteria,2G6I8@200795|Chloroflexi,375AV@32061|Chloroflexia	32061|Chloroflexia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
CMS3_k127_1736864_3	326427.Cagg_2787	7.544e-67	237.0	COG0566@1|root,COG0566@2|Bacteria	2|Bacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	2.1.1.185	ko:K03218,ko:K03437	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
CMS3_k127_1736864_1	525904.Tter_1654	1.573e-129	422.0	COG0216@1|root,COG0216@2|Bacteria,2NNKY@2323|unclassified Bacteria	2|Bacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02835,ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CMS3_k127_1736864_2	552811.Dehly_1372	2.205e-113	380.0	COG0124@1|root,COG0124@2|Bacteria,2G64E@200795|Chloroflexi,34CWB@301297|Dehalococcoidia	301297|Dehalococcoidia	J	histidyl-tRNA aminoacylation	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
CMS3_k127_1736864_0	552811.Dehly_1359	3.015e-220	711.0	COG0317@1|root,COG0317@2|Bacteria,2G67Y@200795|Chloroflexi,34CRS@301297|Dehalococcoidia	301297|Dehalococcoidia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
CMS3_k127_176743_6	512565.AMIS_24220	5.934e-42	167.0	COG2197@1|root,COG2267@1|root,COG2197@2|Bacteria,COG2267@2|Bacteria,2GN4Z@201174|Actinobacteria	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,GerE
CMS3_k127_176743_0	1206732.BAGD01000054_gene1961	5.345e-123	407.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4FWX1@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_176743_4	1123388.AQWU01000029_gene1474	5.175e-64	240.0	COG1804@1|root,COG1804@2|Bacteria,1WIR7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_176743_7	439235.Dalk_2436	8.585e-24	109.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K22295	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
CMS3_k127_176743_5	1173028.ANKO01000035_gene3700	9.375e-60	221.0	COG0524@1|root,COG0524@2|Bacteria,1G2YU@1117|Cyanobacteria,1H8FK@1150|Oscillatoriales	1117|Cyanobacteria	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CMS3_k127_176743_1	1463854.JOHT01000010_gene100	2.087e-102	360.0	COG1804@1|root,COG1804@2|Bacteria,2I9RM@201174|Actinobacteria	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_176743_8	1487923.DP73_09300	1.781e-07	63.0	COG4655@1|root,COG4655@2|Bacteria,1V25X@1239|Firmicutes,24GGW@186801|Clostridia,267CD@186807|Peptococcaceae	186801|Clostridia	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
CMS3_k127_176743_2	401526.TcarDRAFT_0529	1.296e-95	331.0	COG0044@1|root,COG0044@2|Bacteria,1V0MB@1239|Firmicutes,4H75V@909932|Negativicutes	909932|Negativicutes	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_176743_3	388413.ALPR1_14479	2.18e-68	251.0	COG2133@1|root,COG2133@2|Bacteria,4NF0B@976|Bacteroidetes,47K2Q@768503|Cytophagia	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,GSDH
CMS3_k127_177506_3	1121106.JQKB01000065_gene5227	1.285e-24	115.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales	28211|Alphaproteobacteria	C	III protein, CoA-transferase family	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_177506_2	931627.MycrhDRAFT_0691	4.225e-44	184.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,23518@1762|Mycobacteriaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_177506_0	1123504.JQKD01000004_gene5111	3.69e-62	224.0	COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2VMK1@28216|Betaproteobacteria,4AEM7@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_177506_1	330084.JNYZ01000046_gene1933	7.969e-56	209.0	COG0491@1|root,COG0491@2|Bacteria,2GMSA@201174|Actinobacteria	201174|Actinobacteria	S	Beta-lactamase	ytnP_1	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_177506_4	1206729.BAFZ01000061_gene3775	1.275e-16	87.0	COG0030@1|root,COG0030@2|Bacteria,2H1TK@201174|Actinobacteria,4FUTS@85025|Nocardiaceae	201174|Actinobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family	-	-	2.1.1.184	ko:K00561	-	-	R10716	RC00003,RC03257	br01600,ko00000,ko01000,ko01504,ko03009	-	-	-	RrnaAD
CMS3_k127_181465_3	926690.KE386573_gene1768	3.044e-12	74.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,23VQJ@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_181465_1	926550.CLDAP_37300	4.116e-108	359.0	COG1064@1|root,COG1064@2|Bacteria,2G829@200795|Chloroflexi	200795|Chloroflexi	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
CMS3_k127_181465_2	134676.ACPL_3997	1.363e-70	258.0	COG0549@1|root,COG0549@2|Bacteria,2HWQ6@201174|Actinobacteria,4D95H@85008|Micromonosporales	201174|Actinobacteria	E	Amino acid kinase family	arcC	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
CMS3_k127_181465_0	1173024.KI912148_gene3523	8.616e-170	544.0	COG2403@1|root,COG2403@2|Bacteria,1G1FF@1117|Cyanobacteria	1117|Cyanobacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	cobW
CMS3_k127_1827119_3	1333998.M2A_0425	9.97e-58	219.0	COG2271@1|root,COG2271@2|Bacteria,1QXWV@1224|Proteobacteria,2TYHZ@28211|Alphaproteobacteria,4BTBC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_1827119_0	1114856.C496_19525	1.177e-84	289.0	COG2897@1|root,arCOG02019@2157|Archaea,2XW8Q@28890|Euryarchaeota,23UHH@183963|Halobacteria	183963|Halobacteria	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
CMS3_k127_1827119_2	479434.Sthe_2325	4.782e-74	260.0	COG0451@1|root,COG0451@2|Bacteria,2G9SG@200795|Chloroflexi	200795|Chloroflexi	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS3_k127_1827119_8	37919.EP51_35160	5.922e-09	64.0	COG3576@1|root,COG3576@2|Bacteria,2I3RW@201174|Actinobacteria,4G0JU@85025|Nocardiaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_1827119_5	113395.AXAI01000009_gene2366	3.982e-37	149.0	COG1247@1|root,COG1247@2|Bacteria,1R6UW@1224|Proteobacteria,2U09H@28211|Alphaproteobacteria,3JQVX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Acetyltransferase (GNAT) domain	MA20_16670	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_1827119_4	595537.Varpa_5318	1.857e-41	160.0	COG1247@1|root,COG1247@2|Bacteria,1R6UW@1224|Proteobacteria,2W2QC@28216|Betaproteobacteria,4AHQC@80864|Comamonadaceae	28216|Betaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_1827119_1	710687.KI912270_gene4816	2.205e-74	267.0	COG2141@1|root,COG2141@2|Bacteria,2GMRE@201174|Actinobacteria,23EWI@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_1827119_7	1042156.CXIVA_13170	2.547e-16	89.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,36DMH@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
CMS3_k127_1827119_6	582515.KR51_00022190	2.001e-28	127.0	COG0420@1|root,COG0420@2|Bacteria,1FZXM@1117|Cyanobacteria	1117|Cyanobacteria	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
CMS3_k127_182714_2	439235.Dalk_1981	3.177e-95	321.0	COG1028@1|root,COG1028@2|Bacteria,1MXNY@1224|Proteobacteria,43AI2@68525|delta/epsilon subdivisions	1224|Proteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059,ko:K18335	ko00051,ko00061,ko00333,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,map00051,map00061,map00333,map00780,map01040,map01100,map01120,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R10690,R11671	RC00029,RC00089,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_182714_7	1463864.JOGO01000025_gene2799	1.362e-43	169.0	COG0491@1|root,COG0491@2|Bacteria,2GMSA@201174|Actinobacteria	201174|Actinobacteria	S	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_182714_6	649831.L083_3664	2.373e-47	181.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	yflN	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_182714_5	767817.Desgi_3217	1.601e-74	260.0	COG4221@1|root,COG4221@2|Bacteria,1UIB4@1239|Firmicutes,25EG6@186801|Clostridia,265GT@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_182714_4	487521.OCU_49440	1.685e-79	279.0	COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,235AT@1762|Mycobacteriaceae	201174|Actinobacteria	C	PFAM CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_182714_9	1089551.KE386572_gene2690	2.579e-26	121.0	COG0662@1|root,COG0662@2|Bacteria,1N56T@1224|Proteobacteria,2UCUS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_182714_3	1429916.X566_19625	6.797e-87	295.0	COG0300@1|root,COG0300@2|Bacteria,1R25N@1224|Proteobacteria,2TZB2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_182714_8	1321778.HMPREF1982_04105	6.038e-33	146.0	COG0477@1|root,COG2814@2|Bacteria,1TRUT@1239|Firmicutes,25E84@186801|Clostridia	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_182714_1	485913.Krac_4715	2.284e-106	363.0	COG2272@1|root,COG2272@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
CMS3_k127_182714_0	1205680.CAKO01000035_gene257	5.666e-112	376.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,2JXBR@204441|Rhodospirillales	204441|Rhodospirillales	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_182714_11	1112204.GPOL_c29660	3.853e-12	78.0	COG1307@1|root,COG1307@2|Bacteria,2GIUV@201174|Actinobacteria,4GAKX@85026|Gordoniaceae	201174|Actinobacteria	S	Uncharacterised protein, DegV family COG1307	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DegV
CMS3_k127_182714_10	652103.Rpdx1_3329	1.14e-16	90.0	COG2030@1|root,COG2030@2|Bacteria,1NYEM@1224|Proteobacteria,2U0F4@28211|Alphaproteobacteria,3JVIY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	dehydratase	MA20_27475	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_182714_12	1306990.BARG01000086_gene8534	0.0001164	46.0	2E8T5@1|root,3333Y@2|Bacteria,2IS1D@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_18515_10	1120917.AQXM01000038_gene2008	1.477e-10	72.0	COG5343@1|root,COG5343@2|Bacteria,2I8NI@201174|Actinobacteria,1WA4R@1268|Micrococcaceae	201174|Actinobacteria	S	Anti-sigma-K factor rskA	rskA	GO:0000988,GO:0000989,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006417,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0010608,GO:0016020,GO:0016989,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0032268,GO:0034248,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	RskA
CMS3_k127_18515_5	1122609.AUGT01000018_gene81	4.141e-29	123.0	COG1595@1|root,COG1595@2|Bacteria,2GP9D@201174|Actinobacteria,4DR5C@85009|Propionibacteriales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigK	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_18515_8	1333523.L593_09185	2.886e-14	84.0	arCOG10180@1|root,arCOG10180@2157|Archaea,2XUY5@28890|Euryarchaeota,23U72@183963|Halobacteria	183963|Halobacteria	S	membrane-bound metal-dependent	-	-	-	-	-	-	-	-	-	-	-	-	YdjM
CMS3_k127_18515_11	1530186.JQEY01000022_gene506	1.926e-10	70.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
CMS3_k127_18515_3	47763.JNZA01000012_gene6386	1.758e-41	168.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
CMS3_k127_18515_7	585530.HMPREF0183_1990	1.135e-19	94.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
CMS3_k127_18515_6	375286.mma_1586	1.502e-28	120.0	COG2461@1|root,COG2461@2|Bacteria,1QX14@1224|Proteobacteria,2WH3M@28216|Betaproteobacteria,478DM@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS
CMS3_k127_18515_2	1297865.APJD01000007_gene1892	1.401e-67	239.0	COG2267@1|root,COG2267@2|Bacteria,1R4YR@1224|Proteobacteria,2VEYN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS3_k127_18515_9	745277.GRAQ_04951	5.191e-13	76.0	COG0604@1|root,COG0604@2|Bacteria,1MXRX@1224|Proteobacteria,1RPW0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_18515_4	1114959.SZMC14600_16451	3.987e-38	153.0	COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria,4E09P@85010|Pseudonocardiales	201174|Actinobacteria	C	NADPH quinone reductase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_18515_0	247633.GP2143_17291	5.388e-95	325.0	COG1960@1|root,COG1960@2|Bacteria,1R6EH@1224|Proteobacteria,1RMXW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_18515_14	1380394.JADL01000010_gene4256	0.0003375	53.0	COG3509@1|root,COG3509@2|Bacteria,1MXUI@1224|Proteobacteria,2TUS5@28211|Alphaproteobacteria,2JQ28@204441|Rhodospirillales	204441|Rhodospirillales	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
CMS3_k127_18515_15	555088.DealDRAFT_1275	0.0008408	52.0	COG3391@1|root,COG3391@2|Bacteria,1V255@1239|Firmicutes,25BCT@186801|Clostridia	186801|Clostridia	M	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Cytochrom_D1,Lactonase
CMS3_k127_18515_13	397278.JOJN01000004_gene1164	4.045e-05	52.0	COG2010@1|root,COG2010@2|Bacteria,2GKUB@201174|Actinobacteria,4DPAK@85009|Propionibacteriales	201174|Actinobacteria	C	Cytochrome c	qcrC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03889	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_CBB3
CMS3_k127_18515_12	1120746.CCNL01000014_gene2052	2.75e-05	57.0	COG0785@1|root,COG0785@2|Bacteria,2NPE4@2323|unclassified Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
CMS3_k127_185944_1	479434.Sthe_2785	1.885e-54	204.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	2.8.1.7,4.4.1.16	ko:K03980,ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000,ko01011,ko02000	2.A.66.4	-	-	Peptidase_M28,SLH
CMS3_k127_185944_0	2002.JOEQ01000026_gene370	3.738e-61	225.0	COG2141@1|root,COG2141@2|Bacteria,2GMRE@201174|Actinobacteria,4EHHD@85012|Streptosporangiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_1864166_0	1429916.X566_14885	2.213e-127	419.0	COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2TRM9@28211|Alphaproteobacteria,3K2PH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
CMS3_k127_1864166_1	1283299.AUKG01000002_gene4021	3.528e-43	165.0	COG1024@1|root,COG1024@2|Bacteria,2GJ63@201174|Actinobacteria,4CS7T@84995|Rubrobacteria	84995|Rubrobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_1911469_10	926550.CLDAP_14760	9.12e-14	84.0	COG3063@1|root,COG3063@2|Bacteria,2G79Z@200795|Chloroflexi	200795|Chloroflexi	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	zf-B_box
CMS3_k127_1911469_5	552811.Dehly_0011	8.361e-69	243.0	COG0613@1|root,COG0613@2|Bacteria,2G6H4@200795|Chloroflexi,34CSU@301297|Dehalococcoidia	301297|Dehalococcoidia	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
CMS3_k127_1911469_0	479434.Sthe_0703	1.525e-156	510.0	COG1418@1|root,COG1418@2|Bacteria,2G620@200795|Chloroflexi,27Y2Z@189775|Thermomicrobia	189775|Thermomicrobia	S	Domain of unknown function (DUF3552)	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
CMS3_k127_1911469_2	331869.BAL199_24329	3.671e-134	448.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
CMS3_k127_1911469_13	266117.Rxyl_1424	4.841e-12	74.0	COG2137@1|root,COG2137@2|Bacteria	2|Bacteria	S	regulation of DNA repair	recX	GO:0003674,GO:0005575,GO:0005623,GO:0005886,GO:0006282,GO:0008150,GO:0016020,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0044464,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0098772,GO:2001020	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
CMS3_k127_1911469_1	568816.Acin_0363	1.383e-137	447.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,4H2TB@909932|Negativicutes	909932|Negativicutes	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
CMS3_k127_1911469_9	265729.GS18_0201935	3.702e-44	169.0	COG1670@1|root,COG1670@2|Bacteria,1UUXI@1239|Firmicutes,4I685@91061|Bacilli,1ZHU0@1386|Bacillus	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
CMS3_k127_1911469_12	1449350.OCH239_11785	7.641e-13	74.0	COG1872@1|root,COG1872@2|Bacteria,1Q69A@1224|Proteobacteria,2VCFR@28211|Alphaproteobacteria,4KP1E@93682|Roseivivax	28211|Alphaproteobacteria	S	Belongs to the UPF0235 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF167
CMS3_k127_1911469_11	1304888.ATWF01000001_gene735	6.248e-13	72.0	COG0762@1|root,COG0762@2|Bacteria,2GFIV@200930|Deferribacteres	200930|Deferribacteres	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
CMS3_k127_1911469_8	926550.CLDAP_36790	2.212e-49	187.0	COG0345@1|root,COG0345@2|Bacteria,2G5QD@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
CMS3_k127_1911469_7	867903.ThesuDRAFT_01649	2.047e-56	205.0	COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,3WCI6@538999|Clostridiales incertae sedis	186801|Clostridia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	ylmE	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
CMS3_k127_1911469_6	1121106.JQKB01000005_gene2104	1.322e-58	214.0	COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,2JTKV@204441|Rhodospirillales	204441|Rhodospirillales	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
CMS3_k127_1911469_3	926550.CLDAP_31490	5.506e-127	430.0	COG1032@1|root,COG1032@2|Bacteria,2G7YA@200795|Chloroflexi	200795|Chloroflexi	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS3_k127_1911469_14	1463920.JOGB01000056_gene4567	8.592e-08	59.0	COG3576@1|root,COG3576@2|Bacteria,2IKU6@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_1911469_4	994479.GL877878_gene2878	5.098e-75	266.0	COG0491@1|root,COG0491@2|Bacteria,2GMSA@201174|Actinobacteria,4E24F@85010|Pseudonocardiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_1921007_9	883078.HMPREF9695_02692	1.437e-18	89.0	COG2128@1|root,COG2128@2|Bacteria,1QW8V@1224|Proteobacteria,2TWTB@28211|Alphaproteobacteria,3JZDW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1921007_1	1206732.BAGD01000054_gene1961	1.509e-106	359.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4FWX1@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_1921007_7	439235.Dalk_2589	2.753e-33	138.0	COG1432@1|root,COG1432@2|Bacteria,1RJ15@1224|Proteobacteria,43B69@68525|delta/epsilon subdivisions,2WTA1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
CMS3_k127_1921007_2	1123023.JIAI01000019_gene2183	1.988e-98	329.0	COG1024@1|root,COG1024@2|Bacteria,2I9DY@201174|Actinobacteria	201174|Actinobacteria	I	enoyl-CoA hydratase isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_1921007_6	1415780.JPOG01000001_gene64	5.005e-37	146.0	COG2258@1|root,COG2258@2|Bacteria,1RE2Q@1224|Proteobacteria,1SEFF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1921007_5	1298880.AUEV01000003_gene3531	1.66e-43	162.0	COG0346@1|root,COG0346@2|Bacteria,2IKNQ@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_1921007_4	1123024.AUII01000004_gene1474	2.729e-58	212.0	COG2267@1|root,COG2267@2|Bacteria,2IBJN@201174|Actinobacteria,4EF72@85010|Pseudonocardiales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_1921007_0	1121106.JQKB01000017_gene4848	7.037e-151	503.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,2JXBR@204441|Rhodospirillales	204441|Rhodospirillales	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_1921007_3	1347086.CCBA010000003_gene3907	1.139e-81	282.0	COG0657@1|root,COG0657@2|Bacteria,1TQHX@1239|Firmicutes,4HB91@91061|Bacilli,1ZB27@1386|Bacillus	91061|Bacilli	I	COG0657 Esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
CMS3_k127_1921007_8	58123.JOFJ01000018_gene4338	4.759e-23	107.0	COG1695@1|root,COG1695@2|Bacteria,2H1J3@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
CMS3_k127_1922591_2	42256.RradSPS_1165	1.256e-113	375.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_1,SBP_bac_11,SBP_bac_6,SBP_bac_8
CMS3_k127_1922591_1	266117.Rxyl_1174	2.96e-137	454.0	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
CMS3_k127_1922591_3	644966.Tmar_0498	1.088e-96	338.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3WCDT@538999|Clostridiales incertae sedis	186801|Clostridia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.30	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	M00190,M00193	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11	-	-	ABC_tran,TOBE_2
CMS3_k127_1922591_5	1210884.HG799468_gene13642	6.312e-29	119.0	COG2127@1|root,COG2127@2|Bacteria,2J06R@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the ClpS family	-	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
CMS3_k127_1922591_4	1283283.ATXA01000016_gene59	2.669e-43	166.0	COG0622@1|root,COG0622@2|Bacteria	2|Bacteria	S	retrograde transport, endosome to Golgi	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
CMS3_k127_1922591_7	1333998.M2A_2346	0.0005637	52.0	COG3832@1|root,COG3832@2|Bacteria,1NCAD@1224|Proteobacteria,2VFWH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_1922591_0	1123023.JIAI01000003_gene2850	1.92e-151	488.0	COG0183@1|root,COG0183@2|Bacteria,2GKH4@201174|Actinobacteria	201174|Actinobacteria	I	Acetyl-CoA acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1922591_6	1123023.JIAI01000003_gene2851	2.653e-25	121.0	COG1545@1|root,COG1545@2|Bacteria,2GS5U@201174|Actinobacteria	201174|Actinobacteria	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N,OB_aCoA_assoc
CMS3_k127_1929395_6	255470.cbdbA419	0.0009065	44.0	COG0061@1|root,COG0061@2|Bacteria,2G6NK@200795|Chloroflexi,34CNH@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
CMS3_k127_1929395_5	926569.ANT_04780	1.75e-38	153.0	COG0494@1|root,COG0494@2|Bacteria,2G7A1@200795|Chloroflexi	200795|Chloroflexi	L	PFAM NUDIX hydrolase	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
CMS3_k127_1929395_3	1210884.HG799466_gene12570	7.206e-64	228.0	2CEY7@1|root,2Z8CG@2|Bacteria	2|Bacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1929395_0	526225.Gobs_1797	8.555e-269	840.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4ES69@85013|Frankiales	201174|Actinobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CMS3_k127_1929395_2	671143.DAMO_1992	5.727e-104	344.0	COG0479@1|root,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB1	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0247c	Fer2_3,Fer4_8
CMS3_k127_1929395_4	1463900.JOIX01000001_gene6239	1.897e-41	156.0	COG0346@1|root,COG0346@2|Bacteria,2IQB4@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_1929395_1	1479239.JQMU01000001_gene1450	3.092e-137	441.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria,2K0K7@204457|Sphingomonadales	204457|Sphingomonadales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
CMS3_k127_1956325_0	1123023.JIAI01000003_gene2846	1.103e-87	299.0	COG1028@1|root,COG1028@2|Bacteria,2H8QY@201174|Actinobacteria	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
CMS3_k127_1956325_1	357808.RoseRS_0178	1.318e-22	113.0	COG0577@1|root,COG0577@2|Bacteria,2G5WX@200795|Chloroflexi	200795|Chloroflexi	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
CMS3_k127_1967229_0	1207063.P24_08459	3.264e-112	375.0	COG1680@1|root,COG1680@2|Bacteria,1MXHB@1224|Proteobacteria,2U4GK@28211|Alphaproteobacteria,2JRE5@204441|Rhodospirillales	204441|Rhodospirillales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_1967229_2	1227488.C477_01530	1.691e-40	160.0	COG0596@1|root,arCOG01648@2157|Archaea,2XW5K@28890|Euryarchaeota,23TTR@183963|Halobacteria	183963|Halobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
CMS3_k127_1967229_1	706587.Desti_3621	9.646e-69	251.0	COG1804@1|root,COG1804@2|Bacteria,1PJ8S@1224|Proteobacteria,434AS@68525|delta/epsilon subdivisions,2X2A7@28221|Deltaproteobacteria,2MRVI@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_1967229_3	1382356.JQMP01000001_gene836	0.0006324	48.0	COG0630@1|root,COG0630@2|Bacteria,2G943@200795|Chloroflexi,27YBM@189775|Thermomicrobia	189775|Thermomicrobia	NU	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1969574_3	1380394.JADL01000007_gene4673	1.263e-56	201.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales	28211|Alphaproteobacteria	C	III protein, CoA-transferase family	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_1969574_1	1411123.JQNH01000001_gene2071	5.554e-84	286.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.1.1.41,4.2.1.17	ko:K01692,ko:K11264	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R00923,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00097,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_1969574_0	1449126.JQKL01000016_gene2873	1.922e-121	403.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia	186801|Clostridia	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_1969574_4	309801.trd_0903	1.234e-47	190.0	COG1099@1|root,COG1099@2|Bacteria,2GBCZ@200795|Chloroflexi,27YTV@189775|Thermomicrobia	189775|Thermomicrobia	S	with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1969574_2	1166018.FAES_4786	5.601e-67	240.0	COG2055@1|root,COG2055@2|Bacteria,4NGVC@976|Bacteroidetes,47KBZ@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
CMS3_k127_1975915_3	1463858.JOHR01000001_gene6630	6.805e-73	274.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_1975915_8	1123060.JONP01000010_gene2194	2.121e-12	78.0	COG0727@1|root,COG0727@2|Bacteria,1RGTX@1224|Proteobacteria	1224|Proteobacteria	S	oxidoreductase	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
CMS3_k127_1975915_1	1136417.AZWE01000032_gene406	4.646e-128	432.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4D8NU@85008|Micromonosporales	201174|Actinobacteria	E	Peptidase dimerisation domain	argE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_1975915_4	1312959.KI914649_gene313	1.445e-68	243.0	COG0640@1|root,COG3832@1|root,COG0640@2|Bacteria,COG3832@2|Bacteria,2GNW2@201174|Actinobacteria,1WADX@1268|Micrococcaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,HTH_20
CMS3_k127_1975915_2	1128421.JAGA01000002_gene1253	2.747e-101	348.0	COG0464@1|root,COG0464@2|Bacteria	2|Bacteria	O	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS3_k127_1975915_5	1054860.KB913030_gene2397	6.029e-47	182.0	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the UPF0301 (AlgH) family	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
CMS3_k127_1975915_6	298654.FraEuI1c_2849	3.757e-25	113.0	COG0622@1|root,COG0622@2|Bacteria	2|Bacteria	S	retrograde transport, endosome to Golgi	ysnB	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
CMS3_k127_1975915_9	1226325.HMPREF1548_01208	1.407e-05	57.0	COG0681@1|root,COG0681@2|Bacteria,1V2YD@1239|Firmicutes,25CNY@186801|Clostridia,36WYI@31979|Clostridiaceae	186801|Clostridia	U	Peptidase S24-like	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
CMS3_k127_1975915_0	42254.XP_004603868.1	7.875e-176	569.0	COG0028@1|root,KOG1185@2759|Eukaryota,38EFU@33154|Opisthokonta,3BGF6@33208|Metazoa,3CUC0@33213|Bilateria,4815T@7711|Chordata,494NR@7742|Vertebrata,3J1W3@40674|Mammalia	33208|Metazoa	EH	fatty acid alpha-oxidation	HACL1	GO:0001561,GO:0003674,GO:0003824,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0015031,GO:0015833,GO:0016042,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0019395,GO:0019752,GO:0019842,GO:0022607,GO:0030258,GO:0030976,GO:0031907,GO:0031974,GO:0032787,GO:0033036,GO:0033365,GO:0034440,GO:0034613,GO:0036094,GO:0042579,GO:0042802,GO:0042886,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046907,GO:0048037,GO:0050662,GO:0051179,GO:0051234,GO:0051259,GO:0051641,GO:0051649,GO:0055114,GO:0065003,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072329,GO:0072594,GO:0072662,GO:0072663,GO:0097159,GO:1901363,GO:1901575,GO:1901681	-	ko:K12261	ko04146,map04146	-	-	-	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_1975915_7	930169.B5T_01338	2.643e-14	75.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,1XHZR@135619|Oceanospirillales	135619|Oceanospirillales	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_1976633_1	1429916.X566_22120	1.138e-109	366.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,3JX5E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_1976633_5	1123504.JQKD01000012_gene1260	1.537e-25	112.0	COG1545@1|root,COG1545@2|Bacteria,1R44D@1224|Proteobacteria,2VV9U@28216|Betaproteobacteria,4AJFP@80864|Comamonadaceae	28216|Betaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
CMS3_k127_1976633_0	1205680.CAKO01000030_gene4821	1.31e-151	499.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_1976633_3	1122614.JHZF01000011_gene1663	7.049e-85	299.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_1976633_2	1125863.JAFN01000001_gene332	1.45e-105	362.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WINR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55,2.6.1.77	ko:K03851,ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684,R05652	RC00006,RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_1976633_4	485913.Krac_8091	4.635e-47	183.0	COG3393@1|root,COG3393@2|Bacteria,2G8JB@200795|Chloroflexi	200795|Chloroflexi	S	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	FR47
CMS3_k127_1977423_3	710687.KI912270_gene434	2.15e-42	168.0	COG2114@1|root,COG2114@2|Bacteria,2I8W5@201174|Actinobacteria,234SY@1762|Mycobacteriaceae	201174|Actinobacteria	T	PFAM Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
CMS3_k127_1977423_4	1120965.AUBV01000016_gene94	8.365e-24	106.0	2BWYK@1|root,32R5D@2|Bacteria,4NS4D@976|Bacteroidetes	976|Bacteroidetes	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_4,PAS_8
CMS3_k127_1977423_0	1120965.AUBV01000016_gene93	1.142e-76	268.0	COG1235@1|root,COG1235@2|Bacteria,4NM16@976|Bacteroidetes,47U32@768503|Cytophagia	976|Bacteroidetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CMS3_k127_1977423_1	266117.Rxyl_2612	3.366e-69	250.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2I312@201174|Actinobacteria,4CRWF@84995|Rubrobacteria	84995|Rubrobacteria	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	2.7.13.3	ko:K02480	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA_3
CMS3_k127_1977423_2	316274.Haur_1309	5.87e-51	197.0	COG2197@1|root,COG2197@2|Bacteria,2G6JC@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_1977423_5	66429.JOFL01000009_gene1239	0.0001153	52.0	COG1595@1|root,COG2340@1|root,COG1595@2|Bacteria,COG2340@2|Bacteria,2GJ21@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	-	-	-	-	-	-	-	-	-	CAP,Sigma70_r2
CMS3_k127_1977861_3	1207063.P24_00220	4.961e-12	69.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,2JZ9Y@204441|Rhodospirillales	204441|Rhodospirillales	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS3_k127_1977861_2	1051632.TPY_3474	4.142e-63	229.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,3WCHN@538999|Clostridiales incertae sedis	186801|Clostridia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
CMS3_k127_1977861_1	247634.GPB2148_1962	4.257e-114	381.0	COG0121@1|root,COG0121@2|Bacteria,1Q80V@1224|Proteobacteria,1SN0H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phosphoinositide phospholipase C, Ca2+-dependent	-	-	-	-	-	-	-	-	-	-	-	-	PI-PLC-C1
CMS3_k127_1977861_0	926550.CLDAP_25840	1.874e-114	377.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	yteT	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_1979778_1	882378.RBRH_00455	2.725e-59	216.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VP9S@28216|Betaproteobacteria,1K0PK@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
CMS3_k127_1979778_0	1229205.BUPH_08531	3.393e-108	368.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,2VMZS@28216|Betaproteobacteria,1K35W@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	rve
CMS3_k127_1979909_1	425104.Ssed_2347	7.056e-31	130.0	COG0500@1|root,COG2226@2|Bacteria,1MWE7@1224|Proteobacteria	1224|Proteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_1979909_0	640510.BC1001_2064	4.229e-64	238.0	COG0457@1|root,COG0457@2|Bacteria,1N01S@1224|Proteobacteria,2VPBZ@28216|Betaproteobacteria,1K3AW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1985974_3	765420.OSCT_2500	3.39e-14	85.0	COG1595@1|root,COG1595@2|Bacteria,2G6MG@200795|Chloroflexi,375K5@32061|Chloroflexia	32061|Chloroflexia	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1985974_0	1121472.AQWN01000008_gene1974	9.373e-59	218.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,260W6@186807|Peptococcaceae	186801|Clostridia	G	Fructose-1,6-bisphosphate aldolase, class II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
CMS3_k127_1985974_2	1173264.KI913949_gene2323	3.105e-34	143.0	COG0681@1|root,COG0681@2|Bacteria,1G519@1117|Cyanobacteria,1HAKR@1150|Oscillatoriales	1117|Cyanobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
CMS3_k127_1985974_1	479434.Sthe_0937	9.652e-54	198.0	COG0461@1|root,COG0461@2|Bacteria,2G6RG@200795|Chloroflexi,27YBT@189775|Thermomicrobia	189775|Thermomicrobia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
CMS3_k127_1986396_0	316274.Haur_4037	3.906e-63	231.0	COG0598@1|root,COG0598@2|Bacteria,2G6EQ@200795|Chloroflexi,375MB@32061|Chloroflexia	32061|Chloroflexia	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
CMS3_k127_1986396_1	1132509.C447_06501	4.115e-16	85.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,23VQJ@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_1988689_6	1118057.CAGX01000042_gene558	0.0001351	46.0	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,24E7M@186801|Clostridia	186801|Clostridia	T	Response regulator receiver domain protein	-	-	-	ko:K07694	ko02020,map02020	M00480	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
CMS3_k127_1988689_2	1120949.KB903357_gene5007	7.949e-34	149.0	COG0420@1|root,COG0420@2|Bacteria	2|Bacteria	L	3'-5' exonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
CMS3_k127_1988689_0	1229780.BN381_330109	4.18e-168	539.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,3UW9K@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
CMS3_k127_1988689_5	935948.KE386494_gene841	9.317e-24	108.0	COG3870@1|root,COG3870@2|Bacteria,1V6NI@1239|Firmicutes,24N37@186801|Clostridia,42GU4@68295|Thermoanaerobacterales	186801|Clostridia	S	Cyclic-di-AMP receptor	yaaQ	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
CMS3_k127_1988689_3	1101192.KB910516_gene1764	8.49e-30	134.0	COG2206@1|root,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,2TWW9@28211|Alphaproteobacteria,1JTEU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
CMS3_k127_1988689_1	696281.Desru_3268	2.004e-53	200.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia,261Y2@186807|Peptococcaceae	186801|Clostridia	P	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_1988689_4	411461.DORFOR_03275	8.03e-26	106.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,27V35@189330|Dorea	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
CMS3_k127_1991787_1	246197.MXAN_6602	8.827e-23	102.0	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,42TBH@68525|delta/epsilon subdivisions,2WPJ5@28221|Deltaproteobacteria,2YW2S@29|Myxococcales	28221|Deltaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
CMS3_k127_1991787_0	298655.KI912266_gene277	2.615e-76	263.0	COG4912@1|root,COG4912@2|Bacteria,2GNQD@201174|Actinobacteria,4EWG8@85013|Frankiales	201174|Actinobacteria	L	DNA alkylation repair enzyme	alkD	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
CMS3_k127_1991787_2	1150864.MILUP08_46685	2.359e-20	104.0	COG1960@1|root,COG1960@2|Bacteria,2H7DI@201174|Actinobacteria,4DC2X@85008|Micromonosporales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase type 2	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_1991787_3	1267533.KB906736_gene1216	0.0001036	50.0	COG0346@1|root,COG0346@2|Bacteria,3Y5YF@57723|Acidobacteria,2JNP7@204432|Acidobacteriia	204432|Acidobacteriia	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_2002056_3	717785.HYPMC_2840	1.392e-43	168.0	COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2TU6K@28211|Alphaproteobacteria,3N7MZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	FAD dependent oxidoreductase	MA20_03725	-	-	-	-	-	-	-	-	-	-	-	DAO
CMS3_k127_2002056_1	388413.ALPR1_14479	8.205e-90	314.0	COG2133@1|root,COG2133@2|Bacteria,4NF0B@976|Bacteroidetes,47K2Q@768503|Cytophagia	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,GSDH
CMS3_k127_2002056_0	1382356.JQMP01000004_gene261	1.323e-320	1000.0	COG0495@1|root,COG0495@2|Bacteria,2G5MX@200795|Chloroflexi,27XYD@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
CMS3_k127_2002056_6	1423807.BACO01000035_gene974	1.176e-09	68.0	COG1073@1|root,COG1073@2|Bacteria,1UXYN@1239|Firmicutes,4HA7V@91061|Bacilli,3FB9J@33958|Lactobacillaceae	91061|Bacilli	S	Serine hydrolase (FSH1)	yfhR3	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4
CMS3_k127_2002056_5	926569.ANT_15290	1.182e-17	94.0	COG0711@1|root,COG0711@2|Bacteria,2G79J@200795|Chloroflexi	200795|Chloroflexi	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2002056_2	633697.EubceDRAFT1_0224	2.571e-44	166.0	COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia,25WCF@186806|Eubacteriaceae	186801|Clostridia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
CMS3_k127_2002056_4	309801.trd_0096	7.499e-35	142.0	COG0742@1|root,COG0742@2|Bacteria,2G6Y8@200795|Chloroflexi,27Y9Y@189775|Thermomicrobia	189775|Thermomicrobia	L	Conserved hypothetical protein 95	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
CMS3_k127_2007420_2	1274374.CBLK010000026_gene2931	3.614e-13	77.0	COG1713@1|root,COG2318@1|root,COG1713@2|Bacteria,COG2318@2|Bacteria,1V44H@1239|Firmicutes,4HH8H@91061|Bacilli,26VP4@186822|Paenibacillaceae	91061|Bacilli	H	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS3_k127_2007420_3	929562.Emtol_3628	1.692e-06	56.0	COG2318@1|root,COG2318@2|Bacteria,4NSE5@976|Bacteroidetes,47S2U@768503|Cytophagia	976|Bacteroidetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
CMS3_k127_2007420_0	665577.JH993790_gene5213	1.828e-99	338.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_2007420_1	1123504.JQKD01000012_gene1257	3.217e-22	107.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VN0B@28216|Betaproteobacteria,4AH2J@80864|Comamonadaceae	28216|Betaproteobacteria	C	CoA-transferase family III	bbsE	-	2.8.3.15	ko:K07543	ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220	M00418	R05588	RC00014,RC00137	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
CMS3_k127_2008903_1	1229780.BN381_240011	1.606e-47	174.0	COG0258@1|root,COG0258@2|Bacteria,2H2A3@201174|Actinobacteria	201174|Actinobacteria	L	5'-3' exonuclease, C-terminal SAM fold	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
CMS3_k127_2008903_0	509190.Cseg_2634	1.339e-130	423.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2U14P@28211|Alphaproteobacteria,2KJZ7@204458|Caulobacterales	204458|Caulobacterales	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_2008903_2	1128421.JAGA01000002_gene1937	3.166e-31	138.0	COG0477@1|root,COG2814@2|Bacteria,2NS3M@2323|unclassified Bacteria	2|Bacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_2008903_3	138119.DSY3072	7.395e-22	109.0	COG1080@1|root,COG1080@2|Bacteria,1UXQW@1239|Firmicutes,24ZSN@186801|Clostridia,264TW@186807|Peptococcaceae	186801|Clostridia	G	Phosphoenolpyruvate synthase pyruvate phosphate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
CMS3_k127_202035_1	314345.SPV1_14254	8.27e-25	105.0	COG1977@1|root,COG1977@2|Bacteria,1N4Z0@1224|Proteobacteria	1224|Proteobacteria	H	Molybdopterin converting factor, small subunit	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
CMS3_k127_202035_2	330214.NIDE1817	4.317e-15	85.0	COG1135@1|root,COG1135@2|Bacteria,3J0VT@40117|Nitrospirae	40117|Nitrospirae	P	NIL	-	-	-	-	-	-	-	-	-	-	-	-	NIL
CMS3_k127_202035_0	1162668.LFE_1739	9.93e-161	518.0	COG0498@1|root,COG0498@2|Bacteria,3J0FZ@40117|Nitrospirae	40117|Nitrospirae	E	Pyridoxal-phosphate dependent enzyme	thrC1	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_2022863_0	552811.Dehly_1035	2.928e-306	964.0	COG0525@1|root,COG0525@2|Bacteria,2G5VS@200795|Chloroflexi,34D5F@301297|Dehalococcoidia	301297|Dehalococcoidia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
CMS3_k127_2022863_2	237368.SCABRO_02834	3.235e-21	101.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_2022863_1	1157943.KB892705_gene4012	3.917e-45	166.0	COG3871@1|root,COG3871@2|Bacteria,2IFC3@201174|Actinobacteria,238T2@1762|Mycobacteriaceae	201174|Actinobacteria	S	stress protein (general stress protein 26)	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_2023464_1	309801.trd_A0669	4.281e-89	300.0	COG2159@1|root,COG2159@2|Bacteria,2G8DN@200795|Chloroflexi,27Y3J@189775|Thermomicrobia	189775|Thermomicrobia	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
CMS3_k127_2023464_0	1333998.M2A_0706	3.664e-93	321.0	COG0667@1|root,COG0667@2|Bacteria,1R7AM@1224|Proteobacteria,2U0JN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS3_k127_2023464_2	35841.BT1A1_1298	6.179e-67	243.0	COG2272@1|root,COG2272@2|Bacteria,1UXY5@1239|Firmicutes,4HCKV@91061|Bacilli,1ZEEU@1386|Bacillus	91061|Bacilli	I	Belongs to the type-B carboxylesterase lipase family	pnbA	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
CMS3_k127_2024722_0	1121952.ATXT01000013_gene2213	1.541e-64	237.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4FKT0@85023|Microbacteriaceae	201174|Actinobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
CMS3_k127_2024722_1	1120950.KB892771_gene1285	5.865e-16	87.0	COG1309@1|root,COG1309@2|Bacteria,2IIM0@201174|Actinobacteria,4DSC8@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
CMS3_k127_2034312_5	867845.KI911784_gene882	7.271e-110	361.0	COG0444@1|root,COG0444@2|Bacteria,2G61B@200795|Chloroflexi,374U3@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_2034312_0	671143.DAMO_1865	1.043e-222	711.0	COG0441@1|root,COG0441@2|Bacteria,2NNMT@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
CMS3_k127_2034312_2	1123070.KB899255_gene1349	7.112e-143	470.0	COG0439@1|root,COG0439@2|Bacteria,46SIE@74201|Verrucomicrobia,2ITZS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Biotin carboxylase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
CMS3_k127_2034312_9	96561.Dole_2178	1.173e-09	66.0	COG4770@1|root,COG4770@2|Bacteria,1NK07@1224|Proteobacteria,4375X@68525|delta/epsilon subdivisions,2WT0S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
CMS3_k127_2034312_6	138119.DSY0267	1.725e-46	177.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,260V8@186807|Peptococcaceae	186801|Clostridia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
CMS3_k127_2034312_10	1348662.CARG_04310	1.259e-05	51.0	COG0291@1|root,COG0291@2|Bacteria,2GQZW@201174|Actinobacteria,22P78@1653|Corynebacteriaceae	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
CMS3_k127_2034312_7	324602.Caur_0384	4.862e-34	134.0	COG0292@1|root,COG0292@2|Bacteria,2G6V4@200795|Chloroflexi,375NZ@32061|Chloroflexia	32061|Chloroflexia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
CMS3_k127_2034312_3	479434.Sthe_1950	9.134e-125	426.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2G5Q5@200795|Chloroflexi,27Y10@189775|Thermomicrobia	200795|Chloroflexi	EU	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS3_k127_2034312_1	671143.DAMO_1857	5.279e-188	614.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2NNXI@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_2160,iPC815.YPO2428	B3_4,B5,FDX-ACB,tRNA_bind
CMS3_k127_2034312_4	309801.trd_0641	8.26e-116	383.0	COG0016@1|root,COG0016@2|Bacteria,2G5T1@200795|Chloroflexi,27XFG@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
CMS3_k127_2034312_8	304371.MCP_1496	2.658e-13	80.0	COG5549@1|root,arCOG04994@2157|Archaea,2Y4E9@28890|Euryarchaeota	28890|Euryarchaeota	O	Matrixin	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2059482_2	742735.HMPREF9467_02805	5.951e-08	65.0	COG2801@1|root,COG2801@2|Bacteria,1TRNK@1239|Firmicutes,24B7I@186801|Clostridia	186801|Clostridia	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
CMS3_k127_2059482_1	32057.KB217478_gene3147	5.093e-14	75.0	COG1396@1|root,COG1396@2|Bacteria,1G7Q5@1117|Cyanobacteria,1HPFA@1161|Nostocales	1117|Cyanobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS3_k127_2059482_0	118173.KB235914_gene2725	3.688e-40	151.0	COG4679@1|root,COG4679@2|Bacteria,1G6N5@1117|Cyanobacteria,1HC3R@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
CMS3_k127_2059716_6	357808.RoseRS_0193	0.0001834	50.0	COG1418@1|root,COG1418@2|Bacteria,2G7CI@200795|Chloroflexi,375YJ@32061|Chloroflexia	32061|Chloroflexia	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2059716_1	479434.Sthe_0803	7.493e-59	217.0	COG0287@1|root,COG0287@2|Bacteria,2G6BW@200795|Chloroflexi,27XQX@189775|Thermomicrobia	189775|Thermomicrobia	C	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
CMS3_k127_2059716_0	316274.Haur_0970	4.956e-136	447.0	COG0128@1|root,COG0128@2|Bacteria,2G5TT@200795|Chloroflexi,375C6@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
CMS3_k127_2059716_5	552811.Dehly_0084	1.075e-20	94.0	COG2052@1|root,COG2052@2|Bacteria,2GAV2@200795|Chloroflexi,34DEP@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Domain of unknown function (DUF370)	-	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
CMS3_k127_2059716_2	255470.cbdbA42	1.016e-42	164.0	COG0194@1|root,COG0194@2|Bacteria,2G6EW@200795|Chloroflexi,34D78@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
CMS3_k127_2059716_3	345341.KUTG_01275	1.368e-34	135.0	COG0640@1|root,COG0640@2|Bacteria,2IQH9@201174|Actinobacteria,4E5CC@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
CMS3_k127_2059716_4	1242864.D187_004897	1.696e-29	127.0	COG1917@1|root,COG3832@1|root,COG1917@2|Bacteria,COG3832@2|Bacteria,1REB4@1224|Proteobacteria	1224|Proteobacteria	S	activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_2059716_7	443255.SCLAV_1881	0.0006882	51.0	COG2197@1|root,COG2197@2|Bacteria,2GR77@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
CMS3_k127_2067767_20	1205680.CAKO01000029_gene5173	0.0004119	48.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TS6G@28211|Alphaproteobacteria,2JREY@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_2067767_18	243164.DET0734	6.013e-08	61.0	COG2331@1|root,COG2331@2|Bacteria,2GATM@200795|Chloroflexi,34DB9@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
CMS3_k127_2067767_0	1169161.KB897734_gene384	2.526e-115	384.0	COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_2067767_2	477641.MODMU_3960	1.291e-80	282.0	COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria,4EU2T@85013|Frankiales	201174|Actinobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_2067767_3	797303.Natpe_3351	1.601e-79	292.0	COG3387@1|root,arCOG03285@2157|Archaea,2XWCI@28890|Euryarchaeota,23UHI@183963|Halobacteria	183963|Halobacteria	G	COG3387 Glucoamylase and related glycosyl hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2067767_6	58123.JOFJ01000003_gene2212	1.145e-69	248.0	COG4122@1|root,COG4122@2|Bacteria,2GQ0Z@201174|Actinobacteria,4EIH4@85012|Streptosporangiales	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
CMS3_k127_2067767_19	1123355.JHYO01000007_gene452	5.963e-05	48.0	COG0483@1|root,COG0483@2|Bacteria,1N7D7@1224|Proteobacteria,2UF6T@28211|Alphaproteobacteria,36YX0@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Domain of unknown function (DUF4170)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4170
CMS3_k127_2067767_16	3067.XP_002958724.1	6.607e-34	145.0	COG0225@1|root,COG0545@1|root,KOG0544@2759|Eukaryota,KOG1635@2759|Eukaryota,37JIQ@33090|Viridiplantae,34ID2@3041|Chlorophyta	3041|Chlorophyta	O	Peptide methionine sulfoxide reductase	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C,PMSR
CMS3_k127_2067767_9	511062.GU3_05375	6.628e-65	238.0	COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,1Y59G@135624|Aeromonadales	135624|Aeromonadales	L	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	-	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
CMS3_k127_2067767_11	479434.Sthe_3003	3.533e-55	210.0	COG1804@1|root,COG1804@2|Bacteria,2GABR@200795|Chloroflexi,27XHH@189775|Thermomicrobia	189775|Thermomicrobia	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_2067767_5	1068980.ARVW01000001_gene5804	5.762e-72	258.0	COG1960@1|root,COG1960@2|Bacteria,2GIXS@201174|Actinobacteria,4DYK5@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	fadE29	GO:0000166,GO:0003674,GO:0005488,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016125,GO:0016127,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0046164,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0051704,GO:0055114,GO:0071704,GO:0071949,GO:0072329,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_2067767_10	479434.Sthe_2999	4.275e-62	230.0	COG1804@1|root,COG1804@2|Bacteria,2GB4P@200795|Chloroflexi,27XYZ@189775|Thermomicrobia	2|Bacteria	C	L-carnitine dehydratase bile acid-inducible protein F	MA20_43260	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_2067767_12	298655.KI912267_gene7280	2.154e-54	204.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS3_k127_2067767_14	43228.XP_007731302.1	1.907e-40	164.0	KOG4055@1|root,KOG4055@2759|Eukaryota,3A4EK@33154|Opisthokonta,3P2Q3@4751|Fungi,3QVF3@4890|Ascomycota,20HQ2@147545|Eurotiomycetes	4751|Fungi	S	DUF1168 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1168
CMS3_k127_2067767_1	1121926.AXWO01000005_gene454	1.315e-104	357.0	COG3004@1|root,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria,4EZ99@85014|Glycomycetales	201174|Actinobacteria	P	Na+/H+ antiporter 1	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
CMS3_k127_2067767_7	1207063.P24_00920	3.603e-67	246.0	COG1024@1|root,COG1024@2|Bacteria,1PU1Q@1224|Proteobacteria,2TSW6@28211|Alphaproteobacteria,2JS2P@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_2067767_13	335543.Sfum_0029	6.15e-54	211.0	COG1122@1|root,COG1122@2|Bacteria	2|Bacteria	P	ATPase activity	tupC	-	3.6.3.55	ko:K01990,ko:K02071,ko:K06857,ko:K16784,ko:K16786	ko02010,map02010	M00186,M00238,M00254,M00581,M00582	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.24,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
CMS3_k127_2067767_8	1123024.AUII01000003_gene3273	1.856e-66	241.0	COG4662@1|root,COG4662@2|Bacteria,2IHU3@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
CMS3_k127_2067767_4	1121423.JONT01000002_gene2191	9.204e-79	273.0	COG2998@1|root,COG2998@2|Bacteria,1TQA9@1239|Firmicutes,249EZ@186801|Clostridia,2605W@186807|Peptococcaceae	186801|Clostridia	H	PBP superfamily domain	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
CMS3_k127_2067767_17	1128421.JAGA01000001_gene2168	2.801e-23	112.0	COG2005@1|root,COG2005@2|Bacteria,2NRCV@2323|unclassified Bacteria	2|Bacteria	S	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K02019,ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000,ko03000	3.A.1.6.2,3.A.1.6.4	-	-	HTH_1,PBP_like_2
CMS3_k127_2067767_15	391037.Sare_4369	2.367e-36	153.0	COG0730@1|root,COG0730@2|Bacteria,2IEJQ@201174|Actinobacteria	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
CMS3_k127_2069100_0	502025.Hoch_4836	1.232e-95	328.0	COG2223@1|root,COG2223@2|Bacteria,1QVKP@1224|Proteobacteria	1224|Proteobacteria	P	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_2069100_4	443255.SCLAV_5085	2.478e-10	72.0	COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
CMS3_k127_2069100_2	1429916.X566_10475	2.394e-63	219.0	COG2030@1|root,COG2030@2|Bacteria,1RD6F@1224|Proteobacteria,2UC91@28211|Alphaproteobacteria,3JZ3D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
CMS3_k127_2069100_1	247633.GP2143_12134	1.512e-66	231.0	COG2030@1|root,COG2030@2|Bacteria	2|Bacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
CMS3_k127_2069100_3	1134445.AJJM01000014_gene404	6.11e-17	81.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
CMS3_k127_2073155_0	10228.TriadP20381	4.799e-30	124.0	KOG4059@1|root,KOG4059@2759|Eukaryota,3A621@33154|Opisthokonta,3BSXB@33208|Metazoa	33208|Metazoa	S	gamma-glutamylcyclotransferase activity	-	GO:0002376,GO:0003674,GO:0003824,GO:0003839,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0007599,GO:0008150,GO:0009611,GO:0016829,GO:0016840,GO:0016842,GO:0032501,GO:0042060,GO:0042381,GO:0045087,GO:0050817,GO:0050878,GO:0050896,GO:0065007,GO:0065008	4.3.2.9	ko:K00682	ko00480,map00480	-	R02743,R03749	RC00064,RC00777	ko00000,ko00001,ko01000	-	-	-	AIG2_2
CMS3_k127_2073155_1	406552.NJ7G_2116	6.894e-30	136.0	COG1653@1|root,arCOG00151@2157|Archaea,2Y2AY@28890|Euryarchaeota,23Z4Y@183963|Halobacteria	183963|Halobacteria	G	COG1653 ABC-type sugar transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2083831_5	1429916.X566_23700	1.159e-29	130.0	COG2021@1|root,COG2021@2|Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	rutD	GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0017144,GO:0019740,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.1.1.24,3.4.11.5,4.1.1.44	ko:K01055,ko:K01259,ko:K09023,ko:K14727,ko:K16434	ko00240,ko00330,ko00362,ko01055,ko01100,ko01120,ko01220,map00240,map00330,map00362,map01055,map01100,map01120,map01220	M00568	R00135,R02991,R03470,R09983	RC00825,RC00938,RC02769	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iEC55989_1330.EC55989_1120,iECO26_1355.ECO26_1247,iECUMN_1333.ECUMN_1192,iSF_1195.SF1012,iSFxv_1172.SFxv_1098,iSSON_1240.SSON_1027,iS_1188.S1082,ic_1306.c1146	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,CMD
CMS3_k127_2083831_0	222534.KB893714_gene1564	9.904e-302	951.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,4ES4C@85013|Frankiales	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
CMS3_k127_2083831_2	1128421.JAGA01000003_gene3142	4.382e-103	351.0	COG0758@1|root,COG0758@2|Bacteria,2NP2V@2323|unclassified Bacteria	2|Bacteria	LU	DNA recombination-mediator protein A	dprA	-	5.99.1.2	ko:K03168,ko:K04096	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_processg_A
CMS3_k127_2083831_4	1382306.JNIM01000001_gene2574	9.029e-67	248.0	COG1253@1|root,COG1253@2|Bacteria,2G6D1@200795|Chloroflexi	200795|Chloroflexi	S	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
CMS3_k127_2083831_3	926569.ANT_08650	1.18e-101	348.0	COG1207@1|root,COG1207@2|Bacteria,2G5VC@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
CMS3_k127_2083831_1	255470.cbdbA65	1.157e-149	488.0	COG0013@1|root,COG0013@2|Bacteria,2G5KW@200795|Chloroflexi,34CVN@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
CMS3_k127_2102997_5	262316.MAP_0128c	3.672e-101	338.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,236R5@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_2102997_8	478741.JAFS01000001_gene1646	2.476e-90	314.0	COG0624@1|root,COG0624@2|Bacteria,46SJS@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS3_k127_2102997_14	797303.Natpe_3542	9.622e-52	194.0	COG1250@1|root,arCOG00250@2157|Archaea,2XVEM@28890|Euryarchaeota,23TQR@183963|Halobacteria	183963|Halobacteria	I	3-hydroxyacyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N
CMS3_k127_2102997_26	754252.PFREUD_00640	5.057e-05	48.0	COG0526@1|root,COG0526@2|Bacteria,2IKMI@201174|Actinobacteria,4DRPF@85009|Propionibacteriales	201174|Actinobacteria	CO	Thioredoxin	thiX	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
CMS3_k127_2102997_10	926550.CLDAP_35570	1.268e-64	233.0	COG0664@1|root,COG0664@2|Bacteria,2G6WI@200795|Chloroflexi	200795|Chloroflexi	K	PFAM Cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CMS3_k127_2102997_24	926550.CLDAP_21350	3.835e-07	57.0	299CS@1|root,2ZWFP@2|Bacteria,2G9JC@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2102997_15	1440774.Y900_013065	1.374e-45	173.0	COG3467@1|root,COG3467@2|Bacteria,2H4HR@201174|Actinobacteria,23DFY@1762|Mycobacteriaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_2102997_11	1160137.KB907308_gene6991	1.061e-63	228.0	COG2084@1|root,COG2084@2|Bacteria,2GTGE@201174|Actinobacteria,4G4IQ@85025|Nocardiaceae	201174|Actinobacteria	I	Domain of unknown function (DUF1932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,F420_oxidored,NAD_binding_2
CMS3_k127_2102997_1	926569.ANT_05220	9.541e-174	583.0	COG0405@1|root,COG0405@2|Bacteria,2G5R2@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CMS3_k127_2102997_3	1123277.KB893228_gene2090	2.395e-147	484.0	COG0154@1|root,COG0154@2|Bacteria,4NF8C@976|Bacteroidetes,47KZQ@768503|Cytophagia	976|Bacteroidetes	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
CMS3_k127_2102997_22	1313172.YM304_21890	6.828e-11	67.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	VY92_08690	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
CMS3_k127_2102997_25	1120958.AULD01000010_gene2460	4.765e-07	59.0	COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria,4FPAP@85023|Microbacteriaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
CMS3_k127_2102997_12	1333998.M2A_1982	2.629e-57	211.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2TQUY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_2102997_6	1206732.BAGD01000054_gene1961	1.475e-97	338.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4FWX1@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_2102997_21	358396.C445_04863	7.958e-16	86.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX4R@28890|Euryarchaeota,23VKS@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_2102997_23	298653.Franean1_2286	3.998e-09	60.0	arCOG13021@1|root,33BFU@2|Bacteria,2GTY3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2102997_17	1235793.C809_02554	3.365e-41	156.0	COG0139@1|root,COG0139@2|Bacteria	2|Bacteria	E	phosphoribosyl-AMP cyclohydrolase activity	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
CMS3_k127_2102997_4	1206732.BAGD01000054_gene1961	1.606e-101	347.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4FWX1@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_2102997_2	192875.XP_004342722.1	2.222e-154	505.0	COG0028@1|root,KOG1185@2759|Eukaryota,38EFU@33154|Opisthokonta	33154|Opisthokonta	EH	thiamine pyrophosphate binding	HACL1	GO:0001561,GO:0003674,GO:0003824,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0015031,GO:0015833,GO:0016042,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0019395,GO:0019752,GO:0019842,GO:0022607,GO:0030258,GO:0030976,GO:0031907,GO:0031974,GO:0032787,GO:0033036,GO:0033365,GO:0034440,GO:0034613,GO:0036094,GO:0042579,GO:0042802,GO:0042886,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046907,GO:0048037,GO:0050662,GO:0051179,GO:0051234,GO:0051259,GO:0051641,GO:0051649,GO:0055114,GO:0065003,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072329,GO:0072594,GO:0072662,GO:0072663,GO:0097159,GO:1901363,GO:1901575,GO:1901681	-	ko:K12261	ko04146,map04146	-	-	-	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_2102997_18	1121949.AQXT01000002_gene1339	3.001e-32	134.0	COG1545@1|root,COG1545@2|Bacteria,1R44D@1224|Proteobacteria,2U9D4@28211|Alphaproteobacteria,43YX9@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
CMS3_k127_2102997_7	749927.AMED_2513	2.299e-91	321.0	COG0183@1|root,COG0183@2|Bacteria,2GKFR@201174|Actinobacteria,4E22C@85010|Pseudonocardiales	201174|Actinobacteria	I	lipid-transfer protein	ltp2	-	-	-	-	-	-	-	-	-	-	-	Thiolase_N
CMS3_k127_2102997_19	644966.Tmar_1733	1.285e-23	108.0	COG1670@1|root,COG1670@2|Bacteria,1V2FI@1239|Firmicutes,25B0M@186801|Clostridia,3WDSJ@538999|Clostridiales incertae sedis	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
CMS3_k127_2102997_16	1122182.KB903814_gene2888	6.429e-42	161.0	COG0406@1|root,COG0406@2|Bacteria,2IJ7S@201174|Actinobacteria,4DDQU@85008|Micromonosporales	201174|Actinobacteria	G	Histidine phosphatase superfamily (branch 1)	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
CMS3_k127_2102997_9	580340.Tlie_1608	7.382e-71	256.0	COG1804@1|root,COG1804@2|Bacteria,3T9W8@508458|Synergistetes	508458|Synergistetes	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_2102997_20	243365.CV_1591	7.339e-17	91.0	COG1011@1|root,COG1011@2|Bacteria,1RHAB@1224|Proteobacteria,2VYJP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	IA, variant 3	-	-	3.1.3.10,3.8.1.2	ko:K01560,ko:K20866	ko00010,ko00361,ko00625,ko01100,ko01120,map00010,map00361,map00625,map01100,map01120	-	R00947,R05287	RC00078,RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS3_k127_2102997_13	545693.BMQ_3512	9.755e-55	213.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UYA0@1239|Firmicutes,4HDHF@91061|Bacilli,1ZQ5X@1386|Bacillus	91061|Bacilli	GT	Phosphotransferase	yvkC	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
CMS3_k127_2102997_0	1117379.BABA_03844	4.372e-184	590.0	COG4799@1|root,COG4799@2|Bacteria,1VTDE@1239|Firmicutes,4HU50@91061|Bacilli,1ZFG8@1386|Bacillus	91061|Bacilli	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
CMS3_k127_2107547_3	1048339.KB913029_gene4512	1.437e-42	171.0	COG0477@1|root,COG2814@2|Bacteria,2H4H5@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
CMS3_k127_2107547_2	1123251.ATWM01000002_gene148	8.656e-55	202.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GMN4@201174|Actinobacteria,4FEPE@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS3_k127_2107547_1	1033739.CAEU01000027_gene3202	1.58e-63	241.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UYA0@1239|Firmicutes,4HDHF@91061|Bacilli	91061|Bacilli	GT	Phosphotransferase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
CMS3_k127_2107547_5	2074.JNYD01000002_gene5561	2.362e-08	63.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GMN4@201174|Actinobacteria,4E1FZ@85010|Pseudonocardiales	201174|Actinobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppsA	-	2.7.9.2	ko:K01007,ko:K21787	ko00333,ko00620,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00333,map00620,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00374,M00837,M00838	R00199,R11662,R11673	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS3_k127_2107547_4	1158050.KB895463_gene3730	6.624e-37	157.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,1W8NY@1268|Micrococcaceae	201174|Actinobacteria	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
CMS3_k127_2107547_0	204669.Acid345_2424	2.517e-95	318.0	COG0258@1|root,COG0258@2|Bacteria,3Y2FG@57723|Acidobacteria,2JME1@204432|Acidobacteriia	204432|Acidobacteriia	L	Helix-hairpin-helix class 2 (Pol1 family) motifs	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
CMS3_k127_2109977_3	1480694.DC28_12675	7.826e-14	74.0	COG3478@1|root,COG3478@2|Bacteria,2JB4S@203691|Spirochaetes	203691|Spirochaetes	S	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)	-	-	-	ko:K07069	-	-	-	-	ko00000	-	-	-	zinc_ribbon_13
CMS3_k127_2109977_4	47763.JNZA01000012_gene6470	7.955e-10	69.0	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
CMS3_k127_2109977_1	1382306.JNIM01000001_gene3677	3.454e-52	198.0	COG2141@1|root,COG2141@2|Bacteria,2G727@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
CMS3_k127_2109977_0	1473546.CH76_12575	3.185e-78	275.0	COG1028@1|root,COG1028@2|Bacteria,1U2GS@1239|Firmicutes,4H9R9@91061|Bacilli,3IX9R@400634|Lysinibacillus	91061|Bacilli	IQ	Short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_2109977_2	1464048.JNZS01000009_gene5877	1.7e-20	98.0	2BWWR@1|root,2ZG0F@2|Bacteria,2IJ2X@201174|Actinobacteria,4DDGM@85008|Micromonosporales	201174|Actinobacteria	S	pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_2133822_6	856793.MICA_2339	3.598e-07	62.0	COG4872@1|root,COG4872@2|Bacteria,1N4JN@1224|Proteobacteria,2UE2X@28211|Alphaproteobacteria,4BSNT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
CMS3_k127_2133822_3	1122917.KB899660_gene2041	2.791e-12	74.0	COG4929@1|root,COG4929@2|Bacteria,1VA4K@1239|Firmicutes,4IS0U@91061|Bacilli	91061|Bacilli	S	GDYXXLXY protein	-	-	-	-	-	-	-	-	-	-	-	-	GDYXXLXY
CMS3_k127_2133822_5	1123508.JH636441_gene3020	2.615e-08	63.0	291S1@1|root,2ZPBY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2133822_4	100226.SCO5312	1.932e-08	61.0	COG3871@1|root,COG3871@2|Bacteria,2I31R@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_2133822_2	381764.Fnod_1036	1.177e-12	72.0	COG1917@1|root,COG1917@2|Bacteria,2GDDZ@200918|Thermotogae	200918|Thermotogae	S	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_2133822_0	1382306.JNIM01000001_gene57	7.086e-67	245.0	COG2141@1|root,COG2141@2|Bacteria,2G99A@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_2133822_1	1463920.JOGB01000031_gene6038	2.81e-13	73.0	COG0644@1|root,COG0644@2|Bacteria,2GJDF@201174|Actinobacteria	201174|Actinobacteria	C	Tryptophan halogenase	-	-	-	ko:K21256	ko01059,ko01130,map01059,map01130	M00833,M00834	R11414	RC01363	ko00000,ko00001,ko00002	-	-	-	Trp_halogenase
CMS3_k127_2137282_0	329726.AM1_3288	2.401e-32	130.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	fosB	GO:0003674,GO:0003824,GO:0004364,GO:0008150,GO:0016740,GO:0016765,GO:0042221,GO:0046677,GO:0050896	2.5.1.18	ko:K11210,ko:K21253,ko:K21264,ko:K21265	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Glyoxalase
CMS3_k127_2164371_0	1121106.JQKB01000054_gene4466	6.782e-116	395.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,2JPKU@204441|Rhodospirillales	204441|Rhodospirillales	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
CMS3_k127_2164371_1	1054213.HMPREF9946_02301	1.146e-23	106.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria,2JR8N@204441|Rhodospirillales	204441|Rhodospirillales	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
CMS3_k127_2167956_1	1463857.JOFZ01000004_gene2679	8.201e-61	214.0	COG1878@1|root,COG1878@2|Bacteria,2GK9Y@201174|Actinobacteria	201174|Actinobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
CMS3_k127_2167956_0	479434.Sthe_0907	4.834e-157	515.0	COG0154@1|root,COG0154@2|Bacteria,2G7WJ@200795|Chloroflexi,27XWA@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS3_k127_2171007_0	479434.Sthe_1442	2.721e-103	350.0	COG0621@1|root,COG0621@2|Bacteria,2G5ZJ@200795|Chloroflexi,27XFB@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
CMS3_k127_2171007_4	1205910.B005_0724	4.1e-11	67.0	COG1550@1|root,COG1550@2|Bacteria,2IQW4@201174|Actinobacteria,4EK9F@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
CMS3_k127_2171007_2	926569.ANT_11700	4.465e-41	166.0	COG1386@1|root,COG1386@2|Bacteria,2G6V6@200795|Chloroflexi	200795|Chloroflexi	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
CMS3_k127_2171007_1	552811.Dehly_1588	4.586e-50	190.0	COG2159@1|root,COG2159@2|Bacteria,2G6CW@200795|Chloroflexi,34CYX@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
CMS3_k127_2171007_3	414684.RC1_3091	1.92e-20	103.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2U7FV@28211|Alphaproteobacteria,2JSQA@204441|Rhodospirillales	204441|Rhodospirillales	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
CMS3_k127_2184339_2	1121272.KB903249_gene1664	6.06e-43	180.0	COG3292@1|root,COG3292@2|Bacteria,2I71F@201174|Actinobacteria,4DKYH@85008|Micromonosporales	201174|Actinobacteria	T	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2184339_0	113395.AXAI01000003_gene5746	7.227e-79	273.0	COG2050@1|root,COG2050@2|Bacteria,1R5RX@1224|Proteobacteria,2U1DZ@28211|Alphaproteobacteria,3JVKP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Thioesterase-like superfamily	MA20_24410	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
CMS3_k127_2184339_3	471853.Bcav_4211	5.749e-38	150.0	COG2411@1|root,COG2411@2|Bacteria,2IN3A@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2184339_5	1463854.JOHT01000014_gene4987	1.079e-23	107.0	COG0778@1|root,COG0778@2|Bacteria,2IPN9@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS3_k127_2184339_1	479434.Sthe_2506	7.215e-46	185.0	COG0477@1|root,COG2814@2|Bacteria,2G6D7@200795|Chloroflexi	2|Bacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_2184339_4	1273538.G159_16345	9.391e-26	123.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26ECD@186818|Planococcaceae	91061|Bacilli	E	substrate-binding protein	dppA_1	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_2194131_1	926550.CLDAP_35260	9.558e-143	474.0	COG1132@1|root,COG1132@2|Bacteria,2G66A@200795|Chloroflexi	200795|Chloroflexi	V	ABC transporter, transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_2194131_0	926569.ANT_02600	5.156e-148	490.0	COG1132@1|root,COG1132@2|Bacteria,2G5RP@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_2194131_2	311424.DhcVS_293	1.421e-124	417.0	COG3567@1|root,COG3567@2|Bacteria,2G7F0@200795|Chloroflexi,34DDN@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Phage portal protein, SPP1 Gp6-like	-	-	-	-	-	-	-	-	-	-	-	-	Phage_prot_Gp6
CMS3_k127_2194131_6	552811.Dehly_0177	1.618e-15	82.0	2A3TQ@1|root,30SBK@2|Bacteria,2G9W9@200795|Chloroflexi,34DJK@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2194131_3	552811.Dehly_1275	1.819e-101	353.0	COG1783@1|root,COG1783@2|Bacteria	2|Bacteria	S	DNA packaging	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
CMS3_k127_2194131_7	552811.Dehly_1276	0.0008917	49.0	2BQ9G@1|root,32J4A@2|Bacteria,2GAU8@200795|Chloroflexi,34DCZ@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2194131_5	266117.Rxyl_2559	2.065e-19	96.0	COG1713@1|root,COG1713@2|Bacteria,2H8HJ@201174|Actinobacteria	201174|Actinobacteria	H	Hydrolase, HD family	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS3_k127_2194131_4	562970.Btus_2357	3.824e-23	100.0	COG0501@1|root,COG0501@2|Bacteria,1TP23@1239|Firmicutes,4HB11@91061|Bacilli,2782X@186823|Alicyclobacillaceae	91061|Bacilli	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
CMS3_k127_221659_2	596153.Alide_3760	6.573e-45	171.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2VIQT@28216|Betaproteobacteria,4ACGW@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_221659_4	875328.JDM601_2354	9.997e-32	135.0	COG2050@1|root,COG2050@2|Bacteria,2IQXX@201174|Actinobacteria,23BW8@1762|Mycobacteriaceae	201174|Actinobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS3_k127_221659_1	1382356.JQMP01000003_gene1444	8.598e-109	365.0	COG0462@1|root,COG0462@2|Bacteria,2G5T8@200795|Chloroflexi,27Y4E@189775|Thermomicrobia	189775|Thermomicrobia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
CMS3_k127_221659_0	574087.Acear_0276	6.355e-263	835.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,3WAH3@53433|Halanaerobiales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
CMS3_k127_221659_5	1197130.BAFM01000012_gene2204	7.464e-08	63.0	arCOG02903@1|root,arCOG03612@1|root,arCOG02903@2157|Archaea,arCOG03612@2157|Archaea	2157|Archaea	P	PhoD-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Big_1,DUF1573,PKD,VWA
CMS3_k127_221659_3	909613.UO65_3318	2.383e-34	138.0	COG0645@1|root,COG0645@2|Bacteria,2I4N7@201174|Actinobacteria	201174|Actinobacteria	S	Chloramphenicol phosphotransferase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
CMS3_k127_221659_6	255470.cbdbA387	2.292e-07	57.0	2A4BY@1|root,30SXK@2|Bacteria,2GASQ@200795|Chloroflexi,34D9B@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_222373_0	479431.Namu_1612	4.829e-70	243.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4EVC6@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
CMS3_k127_222373_2	1168059.KB899087_gene1061	1.411e-09	66.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3F0VP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
CMS3_k127_222373_1	56107.Cylst_2613	8.429e-68	248.0	COG1520@1|root,COG1520@2|Bacteria,1GDEQ@1117|Cyanobacteria	1117|Cyanobacteria	S	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans
CMS3_k127_2231256_1	1382306.JNIM01000001_gene1327	3.902e-140	456.0	COG0064@1|root,COG0064@2|Bacteria,2G62Q@200795|Chloroflexi	200795|Chloroflexi	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
CMS3_k127_2231256_4	649831.L083_7773	3.049e-16	85.0	COG3557@1|root,COG3557@2|Bacteria,2IQ8M@201174|Actinobacteria,4DCQR@85008|Micromonosporales	201174|Actinobacteria	J	domain protein associated with RNAses G and E	-	-	-	ko:K07586	-	-	-	-	ko00000	-	-	-	DUF402
CMS3_k127_2231256_0	552811.Dehly_0351	2.117e-142	465.0	COG2256@1|root,COG2256@2|Bacteria,2G5JC@200795|Chloroflexi,34CVS@301297|Dehalococcoidia	301297|Dehalococcoidia	L	MgsA AAA+ ATPase C terminal	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA_assoc_2,MgsA_C,RuvB_N
CMS3_k127_2231256_5	1173021.ALWA01000008_gene1517	1.469e-12	74.0	COG4454@1|root,COG4454@2|Bacteria,1G83X@1117|Cyanobacteria	1117|Cyanobacteria	P	Sulfocyanin (SoxE) domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,SoxE
CMS3_k127_2231256_2	1463857.JOFZ01000004_gene2679	8.486e-64	231.0	COG1878@1|root,COG1878@2|Bacteria,2GK9Y@201174|Actinobacteria	201174|Actinobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
CMS3_k127_2231256_3	1120746.CCNL01000006_gene387	3.239e-35	148.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
CMS3_k127_2240246_3	1896.JOAU01000022_gene4587	2.089e-14	76.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_2240246_0	247633.GP2143_12976	1.013e-96	343.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,1RPE2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Enoyl-CoA hydratase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS3_k127_2240246_1	1347369.CCAD010000080_gene3161	7.1e-56	207.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	echA2	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_2240246_2	525904.Tter_2710	1.982e-34	145.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
CMS3_k127_2249562_13	357808.RoseRS_4388	2.731e-05	55.0	COG5662@1|root,COG5662@2|Bacteria,2G9S9@200795|Chloroflexi,375WU@32061|Chloroflexia	32061|Chloroflexia	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2249562_7	311424.DhcVS_974	3.318e-39	158.0	COG2968@1|root,COG2968@2|Bacteria,2G6UC@200795|Chloroflexi,34CTD@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
CMS3_k127_2249562_4	1416759.AYMR01000011_gene312	1.445e-68	238.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4FKGB@85023|Microbacteriaceae	201174|Actinobacteria	F	dCTP deaminase activity	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
CMS3_k127_2249562_2	309801.trd_0502	3.22e-93	319.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2G5SW@200795|Chloroflexi,27XN2@189775|Thermomicrobia	189775|Thermomicrobia	H	RibD C-terminal domain	-	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
CMS3_k127_2249562_5	500635.MITSMUL_03492	3.533e-49	181.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,4H4M4@909932|Negativicutes	909932|Negativicutes	H	riboflavin synthase, alpha	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
CMS3_k127_2249562_0	443143.GM18_3009	2.772e-154	498.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,43U14@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
CMS3_k127_2249562_6	1262915.BN574_01310	7.892e-47	173.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,4H3ZR@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
CMS3_k127_2249562_8	1408419.JHYG01000002_gene1065	1.254e-36	149.0	COG1213@1|root,COG1213@2|Bacteria,1RKR2@1224|Proteobacteria,2U97V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	MobA-like NTP transferase domain	-	-	2.7.7.74	ko:K07281	ko00562,map00562	-	R09669	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS3_k127_2249562_3	1121406.JAEX01000007_gene2388	1.883e-87	303.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2M80Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
CMS3_k127_2249562_9	479434.Sthe_1360	6.093e-28	121.0	COG2452@1|root,COG2452@2|Bacteria,2G789@200795|Chloroflexi,27YB6@189775|Thermomicrobia	189775|Thermomicrobia	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
CMS3_k127_2249562_11	1120950.KB892801_gene1778	6.456e-11	72.0	COG0181@1|root,COG0181@2|Bacteria,2GMWI@201174|Actinobacteria,4DN1M@85009|Propionibacteriales	201174|Actinobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0510	Porphobil_deam,Porphobil_deamC
CMS3_k127_2249562_12	1463861.JNXE01000037_gene3626	6.868e-09	66.0	2AQQN@1|root,31FY8@2|Bacteria,2IEM3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2249562_10	766499.C357_18307	6.487e-17	91.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,2TS5K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	haloacid dehalogenase, type II	dehII	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
CMS3_k127_2249562_1	311424.DhcVS_1009	5.714e-108	361.0	COG0592@1|root,COG0592@2|Bacteria,2G641@200795|Chloroflexi,34CUN@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
CMS3_k127_2253151_3	1041147.AUFB01000007_gene604	5.584e-19	97.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,4B81P@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	carnitine dehydratase	caiB	GO:0003674,GO:0003824,GO:0008410,GO:0016740,GO:0016782,GO:0047369	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_2253151_1	690585.JNNU01000023_gene2015	7.074e-81	286.0	COG1804@1|root,COG1804@2|Bacteria,1NSWZ@1224|Proteobacteria,2U2UE@28211|Alphaproteobacteria,4BCJ9@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_2253151_0	1429916.X566_15995	2.447e-93	314.0	COG1024@1|root,COG1024@2|Bacteria,1R3U7@1224|Proteobacteria,2TV9G@28211|Alphaproteobacteria,3JU2F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_2253151_2	331869.BAL199_08893	2.469e-69	244.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,4BQ0U@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
CMS3_k127_2256171_0	1443111.JASG01000004_gene1017	1.498e-140	454.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria,3ZWPH@60136|Sulfitobacter	28211|Alphaproteobacteria	CO	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_2256171_2	1342302.JASC01000013_gene2938	5.575e-30	122.0	2E6FA@1|root,3312Q@2|Bacteria,1NCPQ@1224|Proteobacteria,2UKWD@28211|Alphaproteobacteria,3ZXTE@60136|Sulfitobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2256171_4	228405.HNE_2485	9.142e-27	110.0	2E6FA@1|root,3312Q@2|Bacteria,1NCPQ@1224|Proteobacteria,2UKWD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2256171_1	443598.AUFA01000017_gene7407	4.259e-76	264.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TUKJ@28211|Alphaproteobacteria,3JUMA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	MA20_30645	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
CMS3_k127_2256171_3	314271.RB2654_16261	1.565e-29	121.0	COG4430@1|root,COG4430@2|Bacteria	2|Bacteria	F	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,DUF1905,OmdA
CMS3_k127_2256171_5	479432.Sros_5424	4.632e-14	76.0	COG3945@1|root,COG3945@2|Bacteria,2I92G@201174|Actinobacteria,4EI2N@85012|Streptosporangiales	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red,Hemerythrin
CMS3_k127_2258027_3	1454010.JEOE01000044_gene1538	4.155e-75	260.0	COG1793@1|root,COG1793@2|Bacteria,2I2EA@201174|Actinobacteria,4F29M@85016|Cellulomonadaceae	201174|Actinobacteria	L	ATP dependent DNA ligase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
CMS3_k127_2258027_0	1146883.BLASA_3642	1.347e-139	468.0	COG1215@1|root,COG1215@2|Bacteria,2GKFI@201174|Actinobacteria,4ESRY@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	bcsA	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,PilZ
CMS3_k127_2258027_6	1282876.BAOK01000001_gene2226	1.289e-22	111.0	2BYHJ@1|root,33QGK@2|Bacteria,1NTWN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2258027_2	247633.GP2143_17291	5.117e-94	321.0	COG1960@1|root,COG1960@2|Bacteria,1R6EH@1224|Proteobacteria,1RMXW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_2258027_1	1121935.AQXX01000064_gene3308	3.994e-119	399.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,1RQM4@1236|Gammaproteobacteria,1XPTW@135619|Oceanospirillales	135619|Oceanospirillales	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
CMS3_k127_2258027_5	448385.sce0600	7.126e-60	230.0	COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,43F2R@68525|delta/epsilon subdivisions,2X35T@28221|Deltaproteobacteria,2YUDS@29|Myxococcales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.14.13.235	ko:K22027	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
CMS3_k127_2258027_4	1385519.N801_07615	8.712e-70	238.0	arCOG06481@1|root,2ZB4E@2|Bacteria,2I95D@201174|Actinobacteria,4FGJ4@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2263358_0	290512.Paes_2232	3.264e-77	273.0	COG1073@1|root,COG1073@2|Bacteria,1FF06@1090|Chlorobi	1090|Chlorobi	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2263358_1	1232410.KI421428_gene1178	3.29e-60	219.0	COG0596@1|root,COG0596@2|Bacteria,1RGAP@1224|Proteobacteria,42XWU@68525|delta/epsilon subdivisions,2WSMY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_2263358_2	309801.trd_A0786	5.019e-54	205.0	COG0515@1|root,COG0515@2|Bacteria,2G7ZW@200795|Chloroflexi,27YUJ@189775|Thermomicrobia	189775|Thermomicrobia	KLT	Serine/Threonine protein kinases, catalytic domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_2280928_11	362976.HQ_2008A	4.289e-09	63.0	arCOG12135@1|root,arCOG12135@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2280928_5	698757.Pogu_0163	4.314e-52	195.0	COG0846@1|root,arCOG04248@2157|Archaea,2XQBQ@28889|Crenarchaeota	28889|Crenarchaeota	K	form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
CMS3_k127_2280928_10	472759.Nhal_2659	3.256e-17	93.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,1RQ15@1236|Gammaproteobacteria,1X0JQ@135613|Chromatiales	135613|Chromatiales	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2280928_7	1157708.KB907454_gene3109	3.19e-41	164.0	COG2267@1|root,COG2267@2|Bacteria,1NYNM@1224|Proteobacteria	1224|Proteobacteria	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	ybfF	-	-	ko:K01175,ko:K06049	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_2280928_1	118163.Ple7327_2973	4.321e-122	405.0	COG0304@1|root,COG0304@2|Bacteria,1G1J5@1117|Cyanobacteria,3VIR6@52604|Pleurocapsales	1117|Cyanobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS3_k127_2280928_6	1121396.KB892935_gene3861	1.405e-47	194.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,42PZA@68525|delta/epsilon subdivisions,2WJ9A@28221|Deltaproteobacteria,2MKHA@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_2280928_0	1110502.TMO_2448	5.177e-132	430.0	COG1351@1|root,COG1351@2|Bacteria,1MWY8@1224|Proteobacteria,2TTER@28211|Alphaproteobacteria,2JQGP@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
CMS3_k127_2280928_8	479433.Caci_0426	2.17e-38	156.0	COG3871@1|root,COG3871@2|Bacteria,2GWY2@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_2280928_3	1380390.JIAT01000012_gene3177	6.878e-65	239.0	COG0427@1|root,COG0427@2|Bacteria,2IAMG@201174|Actinobacteria,4CT1M@84995|Rubrobacteria	84995|Rubrobacteria	C	Acetyl-CoA hydrolase/transferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C
CMS3_k127_2280928_4	479434.Sthe_2506	2.854e-62	246.0	COG0477@1|root,COG2814@2|Bacteria,2G6D7@200795|Chloroflexi	2|Bacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_2280928_2	96561.Dole_0933	3.661e-87	305.0	COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,42NUM@68525|delta/epsilon subdivisions,2WKR2@28221|Deltaproteobacteria,2MN4P@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 2-nitropropane dioxygenase NPD	-	-	-	-	-	-	-	-	-	-	-	-	NMO
CMS3_k127_2280928_9	1403313.AXBR01000022_gene2832	4.309e-38	165.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,1ZB0F@1386|Bacillus	91061|Bacilli	C	acyl-CoA transferases carnitine dehydratase	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_229569_0	1136417.AZWE01000005_gene4658	4.946e-72	255.0	COG0451@1|root,COG0451@2|Bacteria,2HS3E@201174|Actinobacteria,4DGHU@85008|Micromonosporales	201174|Actinobacteria	M	Nad-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS3_k127_2300367_5	795359.TOPB45_0125	3.709e-08	61.0	2DPS5@1|root,3335G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2703
CMS3_k127_2300367_3	479434.Sthe_1406	9.615e-40	153.0	COG1051@1|root,COG1051@2|Bacteria,2G77J@200795|Chloroflexi,27YGM@189775|Thermomicrobia	189775|Thermomicrobia	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS3_k127_2300367_2	1382356.JQMP01000004_gene532	4.309e-53	203.0	COG2120@1|root,COG2120@2|Bacteria,2G6FB@200795|Chloroflexi,27XM3@189775|Thermomicrobia	189775|Thermomicrobia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS3_k127_2300367_1	1382356.JQMP01000003_gene2180	1.974e-62	231.0	COG1974@1|root,COG1974@2|Bacteria,2G6NC@200795|Chloroflexi,27Y6E@189775|Thermomicrobia	189775|Thermomicrobia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
CMS3_k127_2300367_0	867903.ThesuDRAFT_01077	8.641e-78	271.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3WCYH@538999|Clostridiales incertae sedis	186801|Clostridia	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_2300367_4	555088.DealDRAFT_0939	1.952e-28	130.0	COG1466@1|root,COG1466@2|Bacteria,1W7A3@1239|Firmicutes,25MH9@186801|Clostridia,42K7V@68298|Syntrophomonadaceae	186801|Clostridia	L	DNA polymerase III delta subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
CMS3_k127_230067_1	383372.Rcas_3989	1.27e-29	127.0	COG3935@1|root,COG3935@2|Bacteria,2G6W5@200795|Chloroflexi,3765A@32061|Chloroflexia	32061|Chloroflexia	L	TIGRFAM primosome, DnaD subunit	-	-	-	-	-	-	-	-	-	-	-	-	DnaB_2
CMS3_k127_230067_0	926692.AZYG01000047_gene2664	1.469e-73	256.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,3WANE@53433|Halanaerobiales	186801|Clostridia	L	Replicative DNA helicase	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
CMS3_k127_23284_0	222534.KB893750_gene4288	2.121e-101	342.0	COG2519@1|root,COG2519@2|Bacteria,2GMKZ@201174|Actinobacteria,4EUG4@85013|Frankiales	201174|Actinobacteria	J	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
CMS3_k127_23284_2	1218084.BBJK01000002_gene216	8.24e-67	245.0	COG0654@1|root,COG0654@2|Bacteria,1R7NX@1224|Proteobacteria,2WIBD@28216|Betaproteobacteria,1KB40@119060|Burkholderiaceae	28216|Betaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
CMS3_k127_23284_1	485913.Krac_4939	1.507e-84	294.0	COG2120@1|root,COG2120@2|Bacteria,2G9IP@200795|Chloroflexi	200795|Chloroflexi	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS3_k127_23284_4	441620.Mpop_0316	1.386e-05	53.0	COG5485@1|root,COG5485@2|Bacteria,1RE0T@1224|Proteobacteria,2U870@28211|Alphaproteobacteria,1JWKP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
CMS3_k127_23284_3	555088.DealDRAFT_1223	3.528e-12	67.0	COG2909@1|root,COG2909@2|Bacteria,1VKHN@1239|Firmicutes	1239|Firmicutes	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
CMS3_k127_2334224_8	929556.Solca_1262	3.646e-18	86.0	COG1611@1|root,COG1611@2|Bacteria,4NF20@976|Bacteroidetes,1IQ3T@117747|Sphingobacteriia	976|Bacteroidetes	S	Belongs to the LOG family	fmt2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS3_k127_2334224_11	483219.LILAB_10375	6.955e-05	55.0	COG0708@1|root,COG0708@2|Bacteria,1QXVQ@1224|Proteobacteria,43C8I@68525|delta/epsilon subdivisions,2X7IX@28221|Deltaproteobacteria,2YTYF@29|Myxococcales	28221|Deltaproteobacteria	L	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,He_PIG,LTD
CMS3_k127_2334224_9	1202768.JROF01000034_gene2215	6.366e-07	60.0	arCOG13343@1|root,arCOG13343@2157|Archaea,2XW0J@28890|Euryarchaeota,23TZ4@183963|Halobacteria	183963|Halobacteria	S	Halocarboxylic acid dehydrogenase DehI	-	-	-	-	-	-	-	-	-	-	-	-	DehI
CMS3_k127_2334224_4	1128421.JAGA01000003_gene3532	4.564e-60	218.0	COG5032@1|root,COG5032@2|Bacteria,2NR1S@2323|unclassified Bacteria	2|Bacteria	BDLTU	phosphatidylinositol kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	PI3_PI4_kinase
CMS3_k127_2334224_3	1380391.JIAS01000004_gene2882	1.711e-63	231.0	COG0483@1|root,COG0483@2|Bacteria,1RB24@1224|Proteobacteria,2U5IF@28211|Alphaproteobacteria,2JWIP@204441|Rhodospirillales	204441|Rhodospirillales	G	Inositol monophosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Inositol_P
CMS3_k127_2334224_10	1121406.JAEX01000002_gene922	2.233e-06	57.0	COG2050@1|root,COG2050@2|Bacteria,1NGFY@1224|Proteobacteria,42UY5@68525|delta/epsilon subdivisions,2WSY5@28221|Deltaproteobacteria,2MCPJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
CMS3_k127_2334224_7	1122611.KB903950_gene6424	2.384e-38	149.0	COG1545@1|root,COG1545@2|Bacteria,2II25@201174|Actinobacteria,4EK85@85012|Streptosporangiales	201174|Actinobacteria	EGP	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
CMS3_k127_2334224_0	402881.Plav_2009	3.954e-142	461.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,1JPBG@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	MA20_16305	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C
CMS3_k127_2334224_6	1131813.AQVT01000001_gene1378	3.757e-43	166.0	2DMXW@1|root,32UAS@2|Bacteria,1PP5A@1224|Proteobacteria,2V1NG@28211|Alphaproteobacteria,1JXC5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2334224_1	675635.Psed_4123	6.808e-85	304.0	COG0778@1|root,COG0778@2|Bacteria,2I6AB@201174|Actinobacteria,4E92W@85010|Pseudonocardiales	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS3_k127_2334224_5	552811.Dehly_1381	6.237e-55	201.0	COG3440@1|root,COG3440@2|Bacteria,2G7YM@200795|Chloroflexi	200795|Chloroflexi	L	HNH endonuclease	-	-	-	ko:K07454	-	-	-	-	ko00000	-	-	-	HNH_2
CMS3_k127_2334224_2	285514.JNWO01000001_gene4293	1.996e-82	292.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_2337612_1	1078020.KEK_09332	3.388e-69	245.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,238E1@1762|Mycobacteriaceae	201174|Actinobacteria	C	carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_2337612_0	665577.JH993790_gene5212	2.03e-74	272.0	COG1804@1|root,COG1804@2|Bacteria,2IB9E@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_2337612_2	879212.DespoDRAFT_01339	1.972e-39	154.0	COG2461@1|root,COG2461@2|Bacteria,1QX14@1224|Proteobacteria,43EIT@68525|delta/epsilon subdivisions,2X8HQ@28221|Deltaproteobacteria	1224|Proteobacteria	S	TIGRFAM PAS domain S-box	-	-	-	-	-	-	-	-	-	-	-	-	PAS
CMS3_k127_2337612_3	1121933.AUHH01000033_gene29	0.0004045	50.0	COG3324@1|root,COG3324@2|Bacteria	2|Bacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
CMS3_k127_2346708_1	543632.JOJL01000032_gene6258	1.218e-32	135.0	COG0288@1|root,COG0288@2|Bacteria,2II5B@201174|Actinobacteria,4DK4M@85008|Micromonosporales	201174|Actinobacteria	P	Carbonic anhydrase	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
CMS3_k127_2346708_0	247633.GP2143_12991	5.463e-76	266.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1S0H1@1236|Gammaproteobacteria,1JBTT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Zn-dependent alcohol dehydrogenases	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_2420602_0	670307.HYPDE_23323	5.048e-268	850.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TU9X@28211|Alphaproteobacteria,3N6DP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	metE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
CMS3_k127_2420602_3	311424.DhcVS_969	6.485e-20	93.0	COG0826@1|root,COG0826@2|Bacteria,2GAVB@200795|Chloroflexi,34DF3@301297|Dehalococcoidia	301297|Dehalococcoidia	O	peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2420602_4	710686.Mycsm_01705	1.176e-19	98.0	COG1309@1|root,COG1309@2|Bacteria,2IGXP@201174|Actinobacteria,238UJ@1762|Mycobacteriaceae	201174|Actinobacteria	K	transcriptional	-	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141	-	ko:K22295	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
CMS3_k127_2420602_2	324602.Caur_1278	2.811e-46	183.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	ntcA	-	-	ko:K01420,ko:K10716,ko:K10914,ko:K16922	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko01002,ko02000,ko03000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	HTH_Crp_2,cNMP_binding
CMS3_k127_2420602_6	1127134.NOCYR_1573	4.807e-11	68.0	2EQM1@1|root,33I6Z@2|Bacteria,2GXMH@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
CMS3_k127_2420602_1	1382356.JQMP01000001_gene1155	2.981e-198	640.0	COG1350@1|root,COG1350@2|Bacteria,2G5YY@200795|Chloroflexi,27XSD@189775|Thermomicrobia	189775|Thermomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_2420602_5	1121104.AQXH01000001_gene1409	1.707e-16	84.0	COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,1IRF8@117747|Sphingobacteriia	976|Bacteroidetes	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC
CMS3_k127_2421557_1	243164.DET1426	9.837e-96	325.0	COG0533@1|root,COG0533@2|Bacteria,2G5V0@200795|Chloroflexi,34D4Y@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	gcp	GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CMS3_k127_2421557_6	502025.Hoch_5847	6.751e-20	97.0	2C5BM@1|root,32RFE@2|Bacteria,1Q9I2@1224|Proteobacteria,43E05@68525|delta/epsilon subdivisions,2WZBP@28221|Deltaproteobacteria,2Z1SM@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2421557_7	1521187.JPIM01000004_gene3074	1.028e-05	59.0	COG0631@1|root,COG0631@2|Bacteria,2G72P@200795|Chloroflexi,374Z2@32061|Chloroflexia	32061|Chloroflexia	T	protein serine/threonine phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2421557_3	402881.Plav_3176	4.689e-57	203.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria,1JP0T@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
CMS3_k127_2421557_0	748247.AZKH_2874	2.589e-136	443.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,2KURW@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
CMS3_k127_2421557_5	552811.Dehly_1004	1.126e-44	177.0	COG0127@1|root,COG0127@2|Bacteria,2G6GK@200795|Chloroflexi,34CM3@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
CMS3_k127_2421557_4	667014.Thein_1892	5.391e-54	203.0	COG1980@1|root,COG1980@2|Bacteria,2GH3D@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
CMS3_k127_2421557_2	1198114.AciX9_1128	3.039e-66	238.0	COG0158@1|root,COG0158@2|Bacteria,3Y70S@57723|Acidobacteria,2JKY5@204432|Acidobacteriia	204432|Acidobacteriia	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	-	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
CMS3_k127_2498084_1	298655.KI912266_gene5782	1.203e-40	155.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,4EVGS@85013|Frankiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_2498084_0	103733.JNYO01000009_gene4711	7.891e-67	248.0	COG1073@1|root,COG1073@2|Bacteria,2GMK3@201174|Actinobacteria,4E10C@85010|Pseudonocardiales	201174|Actinobacteria	S	Prolyl oligopeptidase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_4,Hydrolase_4,Peptidase_S9
CMS3_k127_2498084_2	1248917.ANFX01000019_gene2321	5.62e-37	150.0	COG3828@1|root,COG3828@2|Bacteria,1QWCA@1224|Proteobacteria,2U1GQ@28211|Alphaproteobacteria,2K19I@204457|Sphingomonadales	204457|Sphingomonadales	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
CMS3_k127_2505061_1	368407.Memar_0422	1.223e-51	198.0	COG0477@1|root,arCOG00130@2157|Archaea,2XVR7@28890|Euryarchaeota	28890|Euryarchaeota	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,PUCC
CMS3_k127_2505061_0	243164.DET0364	1.203e-68	249.0	COG0793@1|root,COG0793@2|Bacteria,2G6HR@200795|Chloroflexi,34D77@301297|Dehalococcoidia	301297|Dehalococcoidia	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
CMS3_k127_2505061_2	1382304.JNIL01000001_gene2904	1.524e-39	152.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,4HGZX@91061|Bacilli,278BJ@186823|Alicyclobacillaceae	91061|Bacilli	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070930,GO:0071704,GO:1901564	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
CMS3_k127_2505061_3	997346.HMPREF9374_1397	3.104e-27	114.0	COG0393@1|root,COG0393@2|Bacteria,1VADM@1239|Firmicutes,4HKFQ@91061|Bacilli	91061|Bacilli	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
CMS3_k127_2505061_5	530564.Psta_3234	1.424e-05	59.0	COG2931@1|root,COG2931@2|Bacteria,2IZWN@203682|Planctomycetes	203682|Planctomycetes	Q	HemY domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2505061_6	1443665.JACA01000059_gene1151	0.0004407	53.0	COG2911@1|root,COG2911@2|Bacteria,4PKAY@976|Bacteroidetes,1IKVT@117743|Flavobacteriia,2YI14@290174|Aquimarina	976|Bacteroidetes	S	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C
CMS3_k127_2505061_4	1206735.BAGG01000240_gene5821	5.319e-06	59.0	COG3468@1|root,COG3468@2|Bacteria,2HCJX@201174|Actinobacteria,4FW2W@85025|Nocardiaceae	201174|Actinobacteria	MU	IPT/TIG domain	-	-	-	-	-	-	-	-	-	-	-	-	TIG
CMS3_k127_2546016_3	479434.Sthe_1081	3.51e-92	311.0	COG1131@1|root,COG1131@2|Bacteria,2G6B8@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_2546016_10	479434.Sthe_1080	2.998e-22	110.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992,ko:K19341	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC2_membrane_2,ABC2_membrane_4
CMS3_k127_2546016_11	401526.TcarDRAFT_1914	2.174e-10	72.0	COG4655@1|root,COG4655@2|Bacteria,1V25X@1239|Firmicutes,4H46N@909932|Negativicutes	909932|Negativicutes	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
CMS3_k127_2546016_1	59538.XP_005968778.1	1.932e-128	421.0	COG1062@1|root,KOG0022@2759|Eukaryota,397PJ@33154|Opisthokonta,3BIQH@33208|Metazoa,3CYWE@33213|Bilateria,4871P@7711|Chordata,491PB@7742|Vertebrata,3J1Y5@40674|Mammalia	2759|Eukaryota	Q	alcohol dehydrogenase (NAD) activity	ADH1	GO:0000302,GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009410,GO:0009413,GO:0009414,GO:0009415,GO:0009628,GO:0009636,GO:0009651,GO:0009719,GO:0009725,GO:0009737,GO:0009743,GO:0009744,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0014070,GO:0014074,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0031000,GO:0032355,GO:0033993,GO:0034285,GO:0036270,GO:0036293,GO:0042221,GO:0042493,GO:0042542,GO:0042802,GO:0042803,GO:0043279,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046686,GO:0046983,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0055114,GO:0065007,GO:0070482,GO:0071944,GO:0080134,GO:0080135,GO:0097305,GO:1900037,GO:1900039,GO:1901698,GO:1901700	1.1.1.1,1.1.1.284	ko:K00001,ko:K00121,ko:K02267,ko:K13980,ko:K18857	ko00010,ko00071,ko00190,ko00350,ko00592,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,ko05204,map00010,map00071,map00190,map00350,map00592,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map04260,map04714,map04932,map05010,map05012,map05016,map05204	M00154	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310,R10783	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	3.D.4.11,3.D.4.8	-	-	ADH_N,ADH_zinc_N
CMS3_k127_2546016_8	1454010.JEOE01000004_gene42	1.238e-35	145.0	28VK2@1|root,2ZHNE@2|Bacteria,2IBCS@201174|Actinobacteria	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
CMS3_k127_2546016_0	525904.Tter_1709	3.746e-139	464.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2NQNK@2323|unclassified Bacteria	2|Bacteria	EU	Peptidase S9 prolyl oligopeptidase active site	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
CMS3_k127_2546016_6	517722.AEUE01000001_gene2842	5.101e-53	199.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TS6G@28211|Alphaproteobacteria,2KCNC@204457|Sphingomonadales	204457|Sphingomonadales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_2546016_4	479434.Sthe_0537	5.049e-66	238.0	COG1028@1|root,COG1028@2|Bacteria,2G5KB@200795|Chloroflexi,27XUY@189775|Thermomicrobia	200795|Chloroflexi	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_2546016_9	1229172.JQFA01000004_gene1000	1.539e-30	130.0	COG2320@1|root,COG2320@2|Bacteria,1G553@1117|Cyanobacteria,1HBA5@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0157	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
CMS3_k127_2546016_5	1121481.AUAS01000002_gene3527	1.596e-53	207.0	COG1524@1|root,COG1524@2|Bacteria,4PAJU@976|Bacteroidetes,47TWN@768503|Cytophagia	976|Bacteroidetes	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
CMS3_k127_2546016_7	1408224.SAMCCGM7_c6619	8.35e-46	192.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,1NIJG@1224|Proteobacteria,2U09P@28211|Alphaproteobacteria,4BAPG@82115|Rhizobiaceae	28211|Alphaproteobacteria	IT	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,BTAD,Guanylate_cyc,Hydrolase_4,Trans_reg_C
CMS3_k127_2546016_2	1128421.JAGA01000003_gene3678	1.233e-101	372.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2NQCZ@2323|unclassified Bacteria	2|Bacteria	K	NB-ARC domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,BTAD,NB-ARC,TPR_10,TPR_12,TPR_8,Trans_reg_C
CMS3_k127_2546016_12	555088.DealDRAFT_1223	2.671e-09	72.0	COG2909@1|root,COG2909@2|Bacteria,1VKHN@1239|Firmicutes	1239|Firmicutes	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
CMS3_k127_2613_0	1121472.AQWN01000004_gene717	3.831e-123	410.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,24ZA8@186801|Clostridia	186801|Clostridia	C	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_2613_7	1535287.JP74_13065	5.608e-15	80.0	COG4875@1|root,COG4875@2|Bacteria,1N89Y@1224|Proteobacteria,2UKHR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2,SnoaL_3
CMS3_k127_2613_3	266117.Rxyl_1027	3.351e-28	118.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria,4CQ0S@84995|Rubrobacteria	84995|Rubrobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
CMS3_k127_2613_2	1123288.SOV_3c01310	1.826e-32	136.0	COG1571@1|root,COG1571@2|Bacteria,1V2YE@1239|Firmicutes	1239|Firmicutes	S	tRNA wobble cytosine modification	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2613_5	443143.GM18_1826	3.01e-19	96.0	COG0640@1|root,COG0640@2|Bacteria,1RGYC@1224|Proteobacteria,42X86@68525|delta/epsilon subdivisions,2WSJA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
CMS3_k127_2613_4	749222.Nitsa_1829	7.452e-25	111.0	COG1553@1|root,COG1553@2|Bacteria,1RDFR@1224|Proteobacteria,42SBR@68525|delta/epsilon subdivisions,2YPGJ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	PFAM DsrE family protein	-	-	-	ko:K06039	-	-	-	-	ko00000	-	-	-	DrsE
CMS3_k127_2613_1	1255043.TVNIR_1705	8.95e-93	316.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RQS1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
CMS3_k127_261808_1	521098.Aaci_1376	1.622e-100	336.0	COG0074@1|root,COG0074@2|Bacteria,1TPIT@1239|Firmicutes,4HA2J@91061|Bacilli,2792C@186823|Alicyclobacillaceae	91061|Bacilli	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
CMS3_k127_261808_0	1120973.AQXL01000128_gene2869	2.83e-113	382.0	COG0045@1|root,COG0045@2|Bacteria,1TQG4@1239|Firmicutes,4HA3W@91061|Bacilli,277XS@186823|Alicyclobacillaceae	91061|Bacilli	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
CMS3_k127_261808_2	1288083.AUKR01000002_gene4600	1.305e-20	96.0	COG0622@1|root,COG0622@2|Bacteria,2IFVB@201174|Actinobacteria	201174|Actinobacteria	S	Phosphoesterase	ysnB	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
CMS3_k127_2684934_22	316055.RPE_4503	0.0001907	45.0	COG1397@1|root,COG2453@1|root,COG1397@2|Bacteria,COG2453@2|Bacteria,1PMP1@1224|Proteobacteria,2VEJC@28211|Alphaproteobacteria,3K5N2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Cyclin-dependent kinase inhibitor 3 (CDKN3)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2684934_9	406124.ACPC01000015_gene2081	1.341e-77	276.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,1ZB7V@1386|Bacillus	91061|Bacilli	I	Belongs to the thiolase family	pcaF	-	2.3.1.174,2.3.1.223	ko:K02615	ko00360,ko01120,map00360,map01120	-	R00829,R09839	RC00004,RC00326,RC03003	ko00000,ko00001,ko01000	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_2684934_15	390989.JOEG01000011_gene200	2.755e-31	130.0	COG0748@1|root,COG0748@2|Bacteria,2IFHD@201174|Actinobacteria,4DDQ3@85008|Micromonosporales	201174|Actinobacteria	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_2684934_14	933262.AXAM01000004_gene2383	1.045e-40	160.0	COG0613@1|root,COG0613@2|Bacteria,1NFVB@1224|Proteobacteria,43BBY@68525|delta/epsilon subdivisions,2X6R1@28221|Deltaproteobacteria,2MPIB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2889)	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	APH,DUF2889,PHP_C
CMS3_k127_2684934_8	1382306.JNIM01000001_gene1425	8.434e-86	298.0	COG0183@1|root,COG0183@2|Bacteria,2G63J@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_2684934_17	1382306.JNIM01000001_gene1424	4.954e-29	123.0	COG1545@1|root,COG1545@2|Bacteria	2|Bacteria	I	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
CMS3_k127_2684934_18	316274.Haur_4980	4.049e-28	126.0	COG0838@1|root,COG0838@2|Bacteria,2G71E@200795|Chloroflexi,375NS@32061|Chloroflexia	32061|Chloroflexia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
CMS3_k127_2684934_16	552811.Dehly_0833	5.257e-31	129.0	COG0852@1|root,COG0852@2|Bacteria,2G6WD@200795|Chloroflexi,34DAA@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
CMS3_k127_2684934_2	552811.Dehly_0834	1.278e-141	458.0	COG0649@1|root,COG0649@2|Bacteria,2G5JF@200795|Chloroflexi,34D5Q@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
CMS3_k127_2684934_7	255470.cbdbA879	6.605e-86	306.0	COG1005@1|root,COG1005@2|Bacteria,2G60S@200795|Chloroflexi,34CTC@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
CMS3_k127_2684934_21	290402.Cbei_2990	9.26e-14	79.0	COG0839@1|root,COG0839@2|Bacteria,1VAQI@1239|Firmicutes,24NAC@186801|Clostridia,36I8J@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the complex I subunit 6 family	ndhG	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
CMS3_k127_2684934_20	485913.Krac_8283	2.157e-20	98.0	COG0713@1|root,COG0713@2|Bacteria,2G782@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
CMS3_k127_2684934_1	552811.Dehly_0839	1.257e-157	519.0	COG1009@1|root,COG1009@2|Bacteria,2G5NJ@200795|Chloroflexi,34D55@301297|Dehalococcoidia	301297|Dehalococcoidia	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
CMS3_k127_2684934_4	653733.Selin_0615	1.064e-109	380.0	COG1008@1|root,COG1008@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
CMS3_k127_2684934_5	485913.Krac_8280	4.865e-97	335.0	COG1007@1|root,COG1007@2|Bacteria,2G5ZK@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
CMS3_k127_2684934_19	1121430.JMLG01000001_gene2256	4.236e-27	116.0	COG0319@1|root,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,24MQZ@186801|Clostridia,2620D@186807|Peptococcaceae	186801|Clostridia	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	3.5.4.5	ko:K01489,ko:K07042	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000,ko03009	-	-	-	UPF0054
CMS3_k127_2684934_6	383372.Rcas_2293	3.137e-95	333.0	COG2812@1|root,COG3266@1|root,COG2812@2|Bacteria,COG3266@2|Bacteria,2G5PK@200795|Chloroflexi,37532@32061|Chloroflexia	32061|Chloroflexia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
CMS3_k127_2684934_10	479434.Sthe_0945	4.059e-75	257.0	COG0353@1|root,COG0353@2|Bacteria,2G6CT@200795|Chloroflexi,27XUN@189775|Thermomicrobia	189775|Thermomicrobia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
CMS3_k127_2684934_13	479434.Sthe_0953	1.89e-44	172.0	COG1381@1|root,COG1381@2|Bacteria,2G6N7@200795|Chloroflexi,27YAT@189775|Thermomicrobia	189775|Thermomicrobia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
CMS3_k127_2684934_11	243164.DET0389	2.537e-67	241.0	COG0142@1|root,COG0142@2|Bacteria,2G6IZ@200795|Chloroflexi,34CSE@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Polyprenyl synthetase	hepT	-	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110	-	R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
CMS3_k127_2684934_12	338966.Ppro_1702	5.549e-65	235.0	COG0084@1|root,COG2896@1|root,COG0084@2|Bacteria,COG2896@2|Bacteria,1MUC0@1224|Proteobacteria,42MMS@68525|delta/epsilon subdivisions,2WMUI@28221|Deltaproteobacteria,43TZ9@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Radical SAM domain protein	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM,TatD_DNase
CMS3_k127_2684934_0	552811.Dehly_1271	2.256e-205	654.0	COG0143@1|root,COG0143@2|Bacteria,2G5ZU@200795|Chloroflexi,34D7N@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1g
CMS3_k127_2684934_3	243164.DET0384	2.61e-124	406.0	COG0516@1|root,COG0516@2|Bacteria,2G5ZX@200795|Chloroflexi,34CRY@301297|Dehalococcoidia	301297|Dehalococcoidia	C	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
CMS3_k127_2694400_0	479434.Sthe_1593	3.11e-114	391.0	COG0215@1|root,COG0215@2|Bacteria,2G5Z0@200795|Chloroflexi,27XK6@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
CMS3_k127_2694400_1	180281.CPCC7001_1296	1.666e-69	244.0	COG1045@1|root,COG1045@2|Bacteria,1G0WM@1117|Cyanobacteria,22SF3@167375|Cyanobium	1117|Cyanobacteria	E	Serine acetyltransferase, N-terminal	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
CMS3_k127_2694400_2	1378168.N510_02444	6.912e-44	164.0	COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes	1239|Firmicutes	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
CMS3_k127_2694400_3	1386089.N865_02175	1.159e-24	106.0	COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,4FGMU@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
CMS3_k127_2717029_1	1283283.ATXA01000001_gene561	4.509e-52	196.0	COG1024@1|root,COG1024@2|Bacteria,2GN3P@201174|Actinobacteria,4EVPG@85013|Frankiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_2717029_2	745014.OMB55_00010560	0.0002464	54.0	COG4932@1|root,COG4935@1|root,COG4932@2|Bacteria,COG4935@2|Bacteria,1NJV7@1224|Proteobacteria,1RN7Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_4
CMS3_k127_2717029_0	867845.KI911784_gene1260	7.998e-129	439.0	COG0823@1|root,COG1520@1|root,COG0823@2|Bacteria,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	ko:K03641,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.C.1.2	-	-	DUF11,HYR,PD40,PQQ_2,VCBS
CMS3_k127_2735500_9	1463934.JOCF01000022_gene6287	1.104e-25	109.0	COG1024@1|root,COG1024@2|Bacteria,2I2PC@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_2735500_1	1499680.CCFE01000023_gene2582	2.3e-130	434.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4IN2H@91061|Bacilli,1ZMNA@1386|Bacillus	91061|Bacilli	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_2735500_0	646529.Desaci_2311	1.536e-157	524.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,1TPG1@1239|Firmicutes,24BBE@186801|Clostridia,260K6@186807|Peptococcaceae	186801|Clostridia	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,Nitrate_red_gam
CMS3_k127_2735500_5	552811.Dehly_0968	1.082e-54	202.0	COG2086@1|root,COG2086@2|Bacteria,2G72U@200795|Chloroflexi	200795|Chloroflexi	C	electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
CMS3_k127_2735500_4	644966.Tmar_0477	7.745e-58	222.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,3WCFX@538999|Clostridiales incertae sedis	186801|Clostridia	C	PFAM Electron transfer flavoprotein domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
CMS3_k127_2735500_6	128390.XP_009460243.1	3.493e-48	182.0	COG0237@1|root,COG1019@1|root,COG1028@1|root,KOG1319@1|root,KOG1205@2759|Eukaryota,KOG1319@2759|Eukaryota,KOG3220@2759|Eukaryota,KOG3351@2759|Eukaryota,38H33@33154|Opisthokonta,3BCJW@33208|Metazoa,3CSPG@33213|Bilateria,483JW@7711|Chordata,4918F@7742|Vertebrata,4GHJ6@8782|Aves	33208|Metazoa	H	Bifunctional coenzyme A synthase	COASY	GO:0000003,GO:0001667,GO:0002009,GO:0002064,GO:0002065,GO:0002066,GO:0002165,GO:0003006,GO:0003674,GO:0003824,GO:0004140,GO:0004595,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005759,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006928,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007297,GO:0007300,GO:0007303,GO:0007444,GO:0007472,GO:0007476,GO:0007552,GO:0007560,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009653,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0009987,GO:0010631,GO:0015936,GO:0015937,GO:0016020,GO:0016301,GO:0016310,GO:0016477,GO:0016482,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019867,GO:0019953,GO:0022412,GO:0022414,GO:0030154,GO:0030707,GO:0030855,GO:0031090,GO:0031966,GO:0031967,GO:0031968,GO:0031974,GO:0031975,GO:0031981,GO:0032501,GO:0032502,GO:0032504,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035107,GO:0035114,GO:0035120,GO:0035220,GO:0035239,GO:0035295,GO:0040011,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0046390,GO:0046483,GO:0046907,GO:0048468,GO:0048477,GO:0048513,GO:0048563,GO:0048569,GO:0048609,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048856,GO:0048869,GO:0048870,GO:0048878,GO:0051179,GO:0051186,GO:0051188,GO:0051234,GO:0051641,GO:0051649,GO:0051674,GO:0051704,GO:0055086,GO:0055088,GO:0055090,GO:0060429,GO:0060562,GO:0065007,GO:0065008,GO:0070013,GO:0070328,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090130,GO:0090132,GO:0090407,GO:0098588,GO:0098805,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24,2.7.7.3	ko:K02318	ko00770,ko01100,map00770,map01100	M00120	R00130,R03035	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,CoaE
CMS3_k127_2735500_2	96561.Dole_3134	2.375e-107	356.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,42MX4@68525|delta/epsilon subdivisions,2WKVB@28221|Deltaproteobacteria,2MHKN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ATPase associated with various cellular activities AAA_5	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
CMS3_k127_2735500_3	330214.NIDE3564	9.205e-91	335.0	COG4548@1|root,COG4548@2|Bacteria	2|Bacteria	P	von Willebrand factor (vWF) type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
CMS3_k127_2735500_8	1125863.JAFN01000001_gene2040	5.673e-30	131.0	COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,42QER@68525|delta/epsilon subdivisions,2WM9B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_2735500_7	1211815.CBYP010000063_gene1857	6.282e-39	160.0	COG3173@1|root,COG3173@2|Bacteria,2GMZQ@201174|Actinobacteria,4EXAK@85013|Frankiales	201174|Actinobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase
CMS3_k127_28025_2	1267533.KB906740_gene389	2.385e-26	115.0	COG3576@1|root,COG3576@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_28025_0	1278078.G419_10587	1.085e-141	460.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,4G06W@85025|Nocardiaceae	201174|Actinobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
CMS3_k127_28025_1	479434.Sthe_2150	1.294e-58	217.0	COG0683@1|root,COG0683@2|Bacteria,2G7TX@200795|Chloroflexi,27YY0@189775|Thermomicrobia	189775|Thermomicrobia	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
CMS3_k127_2807745_0	1121423.JONT01000009_gene1507	6.734e-80	279.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,24EUD@186801|Clostridia,267G2@186807|Peptococcaceae	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.310,1.1.1.399,1.1.1.95	ko:K00058,ko:K16843	ko00260,ko00270,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513,R05693	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS3_k127_2807745_1	1366050.N234_25195	3.994e-75	261.0	COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2VN7W@28216|Betaproteobacteria,1K9NU@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
CMS3_k127_2807745_2	530564.Psta_2957	5.988e-74	264.0	COG2055@1|root,COG2055@2|Bacteria,2IWXD@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	-	ko:K13574	-	-	-	-	ko00000,ko01000	-	-	-	Ldh_2
CMS3_k127_2807745_3	1356854.N007_12965	8.619e-74	258.0	COG0338@1|root,COG0338@2|Bacteria,1TRDX@1239|Firmicutes,4HDFS@91061|Bacilli	91061|Bacilli	L	Site-specific DNA-methyltransferase (Adenine-specific)	dpnM	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
CMS3_k127_288851_0	867903.ThesuDRAFT_00195	8.72e-258	818.0	COG1061@1|root,COG1205@1|root,COG1061@2|Bacteria,COG1205@2|Bacteria,1TSPA@1239|Firmicutes,25EG8@186801|Clostridia,3WDQS@538999|Clostridiales incertae sedis	186801|Clostridia	KL	PFAM Helicase conserved C-terminal domain	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
CMS3_k127_288851_4	309801.trd_0085	4.419e-33	141.0	COG1853@1|root,COG1853@2|Bacteria,2G9RE@200795|Chloroflexi,27Y9A@189775|Thermomicrobia	189775|Thermomicrobia	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
CMS3_k127_288851_5	479434.Sthe_3319	1.088e-24	117.0	COG2367@1|root,COG2367@2|Bacteria	2|Bacteria	V	Beta-lactamase	blaB	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
CMS3_k127_288851_1	1394178.AWOO02000006_gene3291	8.828e-140	455.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4EH92@85012|Streptosporangiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_288851_2	439235.Dalk_2665	4.721e-100	338.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,42S7G@68525|delta/epsilon subdivisions,2WNH7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_288851_6	227882.SAV_3443	4.947e-13	76.0	COG1714@1|root,COG1714@2|Bacteria,2HGSH@201174|Actinobacteria	201174|Actinobacteria	S	RDD domain containing protein	pra	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	RDD
CMS3_k127_288851_3	264198.Reut_A3406	5.017e-69	241.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2VIVB@28216|Betaproteobacteria,1K02Z@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
CMS3_k127_2890208_4	28072.Nos7524_1286	0.0005175	51.0	COG2931@1|root,COG3210@1|root,COG3291@1|root,COG3595@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria,1GHDQ@1117|Cyanobacteria,1HUA0@1161|Nostocales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114
CMS3_k127_2890208_0	1278078.G419_25964	9.138e-126	434.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,4FW1X@85025|Nocardiaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_2890208_2	697281.Mahau_0958	1.703e-51	201.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,42F4N@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM peptidase S11, D-alanyl-D-alanine carboxypeptidase	dacB2	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
CMS3_k127_2890208_1	404589.Anae109_0474	2.516e-82	282.0	COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,43A9Z@68525|delta/epsilon subdivisions,2X37W@28221|Deltaproteobacteria,2YV2G@29|Myxococcales	28221|Deltaproteobacteria	S	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate	tam	-	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_23,Methyltransf_25
CMS3_k127_2890208_3	439481.Aboo_0320	9.2e-15	77.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,3F2GC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
CMS3_k127_2892261_1	861299.J421_5977	2.13e-89	309.0	COG0665@1|root,COG0665@2|Bacteria,1ZUQF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
CMS3_k127_2892261_2	1089551.KE386572_gene2875	1.468e-53	200.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
CMS3_k127_2892261_3	266265.Bxe_A3541	2.71e-51	191.0	COG1545@1|root,COG1545@2|Bacteria,1REY1@1224|Proteobacteria,2W6ZM@28216|Betaproteobacteria,1KDDK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N,OB_aCoA_assoc
CMS3_k127_2892261_0	402881.Plav_1026	1.217e-158	509.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,1JPBG@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_2904471_4	234267.Acid_5780	1.249e-52	197.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,TPR_8,Trans_reg_C
CMS3_k127_2904471_7	1394178.AWOO02000002_gene1803	1.675e-36	155.0	COG0640@1|root,COG0640@2|Bacteria,2IQQU@201174|Actinobacteria,4EKS7@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
CMS3_k127_2904471_2	298655.KI912266_gene3827	2.137e-75	255.0	COG3832@1|root,COG3832@2|Bacteria,2II8T@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_2904471_10	1001240.GY21_19200	1.276e-10	64.0	COG0262@1|root,COG0262@2|Bacteria,2GYU7@201174|Actinobacteria,4FND8@85023|Microbacteriaceae	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
CMS3_k127_2904471_11	935863.AWZR01000005_gene2268	1.18e-09	69.0	COG0543@1|root,COG0543@2|Bacteria,1QTSK@1224|Proteobacteria,1T1MX@1236|Gammaproteobacteria,1X4EV@135614|Xanthomonadales	135614|Xanthomonadales	CH	ferredoxin--nadp reductase	fpr	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
CMS3_k127_2904471_8	33898.JRHJ01000001_gene632	8.439e-17	85.0	2C19F@1|root,32ZRH@2|Bacteria,2I872@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2904471_9	1150469.RSPPHO_00932	1.163e-13	77.0	COG2114@1|root,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2TSVT@28211|Alphaproteobacteria,2JUSX@204441|Rhodospirillales	204441|Rhodospirillales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
CMS3_k127_2904471_1	270374.MELB17_23125	2.566e-94	314.0	COG1335@1|root,COG1335@2|Bacteria,1N48X@1224|Proteobacteria,1S00N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS3_k127_2904471_6	375286.mma_0959	1.405e-43	171.0	COG4977@1|root,COG4977@2|Bacteria,1R8XV@1224|Proteobacteria,2VKI6@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
CMS3_k127_2904471_12	1356854.N007_17840	3.701e-09	68.0	COG4409@1|root,COG4409@2|Bacteria,1UWZJ@1239|Firmicutes,4I72V@91061|Bacilli,27AI5@186823|Alicyclobacillaceae	91061|Bacilli	G	Photosynthesis system II assembly factor YCF48	-	-	-	-	-	-	-	-	-	-	-	-	BNR
CMS3_k127_2904471_14	292459.STH2005	9.548e-07	61.0	COG5401@1|root,COG5401@2|Bacteria,1U1ZK@1239|Firmicutes,24AQU@186801|Clostridia	186801|Clostridia	S	PFAM Spore germination protein-like Gmad2, bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
CMS3_k127_2904471_5	479434.Sthe_1010	1.318e-52	205.0	COG0226@1|root,COG2843@1|root,COG0226@2|Bacteria,COG2843@2|Bacteria,2G78I@200795|Chloroflexi,27Z2P@189775|Thermomicrobia	189775|Thermomicrobia	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
CMS3_k127_2904471_13	749414.SBI_03990	4.982e-08	63.0	2E8ZP@1|root,33396@2|Bacteria,2IS4U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2904471_3	1246995.AFR_24790	3.166e-68	242.0	COG1305@1|root,COG1305@2|Bacteria,2IIM2@201174|Actinobacteria,4DGSH@85008|Micromonosporales	201174|Actinobacteria	E	Bacterial transglutaminase-like N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
CMS3_k127_2904471_0	448385.sce0813	5.936e-140	449.0	COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,42Q8Q@68525|delta/epsilon subdivisions,2WMKQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
CMS3_k127_2906640_0	1313172.YM304_27660	2.083e-84	295.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
CMS3_k127_2906640_1	292459.STH2345	1.103e-30	133.0	COG1525@1|root,COG1525@2|Bacteria,1VASF@1239|Firmicutes,24G14@186801|Clostridia	186801|Clostridia	L	PFAM nuclease (SNase	nucH	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	SNase
CMS3_k127_2915080_1	479434.Sthe_2033	5.58e-76	271.0	COG0477@1|root,COG0477@2|Bacteria,2G5UF@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_2915080_0	1206732.BAGD01000054_gene1961	1.901e-93	320.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4FWX1@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_2915080_4	383372.Rcas_1955	4.099e-34	140.0	COG0400@1|root,COG0400@2|Bacteria,2G7EK@200795|Chloroflexi,375T4@32061|Chloroflexia	32061|Chloroflexia	S	PFAM phospholipase Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
CMS3_k127_2915080_3	1128421.JAGA01000002_gene1937	1.059e-35	153.0	COG0477@1|root,COG2814@2|Bacteria,2NS3M@2323|unclassified Bacteria	2|Bacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_2915080_2	1282876.BAOK01000001_gene1747	2.053e-54	207.0	COG0596@1|root,COG0596@2|Bacteria,1R9X7@1224|Proteobacteria,2TWIW@28211|Alphaproteobacteria,4BTDE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_2915080_5	1206725.BAFU01000248_gene3250	3.822e-16	81.0	COG1846@1|root,COG1846@2|Bacteria,2IPBX@201174|Actinobacteria,4G1H3@85025|Nocardiaceae	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
CMS3_k127_2916480_3	644283.Micau_3759	1.795e-05	48.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4DCJE@85008|Micromonosporales	201174|Actinobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16,2.8.3.20	ko:K07749,ko:K18313	-	-	R10640,R10641	RC00014	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_2916480_2	479434.Sthe_0680	1.414e-69	258.0	COG0747@1|root,COG0747@2|Bacteria,2GAP8@200795|Chloroflexi,27YXK@189775|Thermomicrobia	189775|Thermomicrobia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_2916480_0	479434.Sthe_0679	6.145e-86	296.0	COG0601@1|root,COG0601@2|Bacteria,2G6BV@200795|Chloroflexi,27XFE@189775|Thermomicrobia	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS3_k127_2916480_1	469381.Dpep_1136	5.022e-84	288.0	COG1173@1|root,COG1173@2|Bacteria,3T9PM@508458|Synergistetes	508458|Synergistetes	EP	ABC transporter, permease protein	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,OppC_N
CMS3_k127_2916480_4	316057.RPD_1581	6.222e-05	50.0	COG1804@1|root,COG1804@2|Bacteria,1NSWZ@1224|Proteobacteria,2U2UE@28211|Alphaproteobacteria,3JWDN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_296091_0	797299.HALLA_11450	3.309e-135	441.0	COG5557@1|root,arCOG02025@2157|Archaea,2XTP4@28890|Euryarchaeota,23S4Z@183963|Halobacteria	183963|Halobacteria	C	Polysulphide reductase	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
CMS3_k127_296091_2	413816.BBJP01000013_gene1015	6.051e-102	347.0	COG0437@1|root,arCOG06257@1|root,arCOG01500@2157|Archaea,arCOG06257@2157|Archaea,2XTS6@28890|Euryarchaeota,23U4H@183963|Halobacteria	183963|Halobacteria	C	COG0437 Fe-S-cluster-containing hydrogenase components 1	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_10,Fer4_11,Fer4_7,Ferredoxin_N
CMS3_k127_296091_4	525904.Tter_0301	7.292e-58	218.0	COG2203@1|root,COG3284@1|root,COG4585@1|root,COG2203@2|Bacteria,COG3284@2|Bacteria,COG4585@2|Bacteria,2NPMD@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07777,ko:K19661,ko:K21405	ko02020,map02020	M00478,M00772	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko03000	-	-	-	GAF,GAF_2,HATPase_c,HisKA,HisKA_3,Lactamase_B_2,PAS,PAS_4,PAS_9
CMS3_k127_296091_3	525904.Tter_0300	4.845e-70	245.0	COG2197@1|root,COG2197@2|Bacteria,2NPMZ@2323|unclassified Bacteria	2|Bacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_296091_1	1089544.KB912942_gene2649	1.268e-113	373.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS
CMS3_k127_2972294_13	1248916.ANFY01000011_gene1083	9.838e-08	55.0	COG0251@1|root,COG0251@2|Bacteria,1RDFC@1224|Proteobacteria,2U8PR@28211|Alphaproteobacteria,2K6NW@204457|Sphingomonadales	204457|Sphingomonadales	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
CMS3_k127_2972294_4	1267533.KB906733_gene3219	1.172e-47	181.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_31
CMS3_k127_2972294_10	1380356.JNIK01000013_gene4039	3.505e-09	66.0	2EN76@1|root,33FV1@2|Bacteria,2GYKJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2972294_6	1273538.G159_17590	2.582e-35	152.0	COG0477@1|root,COG2814@2|Bacteria,1TS1D@1239|Firmicutes,4HCUB@91061|Bacilli,26E16@186818|Planococcaceae	91061|Bacilli	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like
CMS3_k127_2972294_9	1121385.AQXW01000004_gene1956	1.068e-09	65.0	COG0454@1|root,COG0456@2|Bacteria,2IHRD@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	ypeA	-	2.3.1.1	ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
CMS3_k127_2972294_15	1507.HMPREF0262_00168	1.33e-06	54.0	COG1396@1|root,COG1974@1|root,COG1396@2|Bacteria,COG1974@2|Bacteria,1UHUG@1239|Firmicutes,25E2W@186801|Clostridia	186801|Clostridia	K	Peptidase S24-like	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Peptidase_S24
CMS3_k127_2972294_12	1462526.BN990_00243	2.691e-08	66.0	COG4454@1|root,COG4454@2|Bacteria,1V23W@1239|Firmicutes,4HGGT@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
CMS3_k127_2972294_7	748247.AZKH_0580	2.783e-24	117.0	COG4454@1|root,COG4454@2|Bacteria,1RF4H@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2972294_2	1382306.JNIM01000001_gene1045	1.56e-62	222.0	COG2197@1|root,COG2197@2|Bacteria,2G6PA@200795|Chloroflexi	200795|Chloroflexi	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_2972294_5	525904.Tter_0301	1.731e-39	167.0	COG2203@1|root,COG3284@1|root,COG4585@1|root,COG2203@2|Bacteria,COG3284@2|Bacteria,COG4585@2|Bacteria,2NPMD@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07777,ko:K19661,ko:K21405	ko02020,map02020	M00478,M00772	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko03000	-	-	-	GAF,GAF_2,HATPase_c,HisKA,HisKA_3,Lactamase_B_2,PAS,PAS_4,PAS_9
CMS3_k127_2972294_3	479432.Sros_2088	1.998e-62	223.0	COG3629@1|root,COG3629@2|Bacteria,2HTZI@201174|Actinobacteria,4EQJA@85012|Streptosporangiales	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
CMS3_k127_2972294_0	1464048.JNZS01000011_gene4768	1.582e-70	252.0	COG3239@1|root,COG3239@2|Bacteria,2GJKF@201174|Actinobacteria,4D9MG@85008|Micromonosporales	201174|Actinobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
CMS3_k127_2972294_14	1254432.SCE1572_43285	1.096e-07	60.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1PEH3@1224|Proteobacteria,430NV@68525|delta/epsilon subdivisions,2WW17@28221|Deltaproteobacteria,2YTSZ@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Pkinase
CMS3_k127_2972294_8	1380391.JIAS01000015_gene129	3.318e-10	69.0	COG2261@1|root,COG2261@2|Bacteria,1N72W@1224|Proteobacteria,2UBU4@28211|Alphaproteobacteria,2JTUG@204441|Rhodospirillales	204441|Rhodospirillales	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
CMS3_k127_2972294_1	1082933.MEA186_09605	1.834e-70	241.0	COG2346@1|root,COG2346@2|Bacteria,1Q38S@1224|Proteobacteria,2UJT6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Truncated hemoglobins	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
CMS3_k127_2980989_1	298655.KI912266_gene4849	4.999e-30	128.0	COG0596@1|root,COG0596@2|Bacteria,2I9EM@201174|Actinobacteria	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_2980989_2	262316.MAP_1655c	5.987e-26	119.0	COG3688@1|root,COG3688@2|Bacteria,2HS1T@201174|Actinobacteria,23A4M@1762|Mycobacteriaceae	201174|Actinobacteria	S	YacP-like NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN_YacP
CMS3_k127_2980989_0	926550.CLDAP_34140	1.937e-83	300.0	COG2304@1|root,COG2304@2|Bacteria,2G7VX@200795|Chloroflexi	200795|Chloroflexi	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA
CMS3_k127_2981285_0	1219084.AP014508_gene413	1.448e-170	541.0	COG4030@1|root,COG4030@2|Bacteria,2GE3D@200918|Thermotogae	200918|Thermotogae	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
CMS3_k127_2981285_2	272134.KB731324_gene6666	7.318e-20	94.0	COG3795@1|root,COG3795@2|Bacteria,1G6M3@1117|Cyanobacteria,1HBWD@1150|Oscillatoriales	1117|Cyanobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
CMS3_k127_2981285_3	926562.Oweho_2409	7.461e-05	51.0	COG5349@1|root,COG5349@2|Bacteria,4NR71@976|Bacteroidetes,1IJ5K@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
CMS3_k127_2981285_1	525368.HMPREF0591_5036	2.684e-37	156.0	COG2114@1|root,COG2114@2|Bacteria,2I8W5@201174|Actinobacteria,234SY@1762|Mycobacteriaceae	201174|Actinobacteria	T	PFAM Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
CMS3_k127_299025_0	767817.Desgi_0669	1.566e-95	326.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia	186801|Clostridia	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_299025_3	1283299.AUKG01000002_gene4816	2.613e-58	215.0	COG0648@1|root,COG0648@2|Bacteria,2GJJQ@201174|Actinobacteria,4CP9J@84995|Rubrobacteria	84995|Rubrobacteria	L	AP endonuclease family 2	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
CMS3_k127_299025_9	292459.STH3142	2.334e-29	124.0	COG4231@1|root,COG4231@2|Bacteria,1VIY6@1239|Firmicutes,24PDQ@186801|Clostridia	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
CMS3_k127_299025_5	1370125.AUWT01000027_gene5398	3.37e-57	212.0	COG2197@1|root,COG2267@1|root,COG2197@2|Bacteria,COG2267@2|Bacteria,2GN4Z@201174|Actinobacteria,23FBR@1762|Mycobacteriaceae	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,GerE
CMS3_k127_299025_7	1380393.JHVP01000001_gene2456	2.466e-43	181.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2,Methyltransf_25,Methyltransf_31
CMS3_k127_299025_13	1151061.CAJY01000030_gene1765	1.918e-14	83.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_299025_10	537011.PREVCOP_04918	1.098e-27	126.0	COG0756@1|root,COG0756@2|Bacteria,4NNI4@976|Bacteroidetes,2FR7A@200643|Bacteroidia	976|Bacteroidetes	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
CMS3_k127_299025_4	485913.Krac_11442	2.161e-57	207.0	COG0580@1|root,COG0580@2|Bacteria	2|Bacteria	U	water channel activity	glpF	-	-	ko:K02440,ko:K06188,ko:K09874	-	-	-	-	ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.12,1.A.8.2	-	-	MIP
CMS3_k127_299025_1	1121396.KB892935_gene3861	2.605e-62	231.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,42PZA@68525|delta/epsilon subdivisions,2WJ9A@28221|Deltaproteobacteria,2MKHA@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_299025_12	485913.Krac_8476	2.023e-15	83.0	COG3794@1|root,COG3794@2|Bacteria,2G7GX@200795|Chloroflexi	200795|Chloroflexi	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
CMS3_k127_299025_11	709986.Deima_2679	6.537e-21	100.0	COG0344@1|root,COG0344@2|Bacteria,1WJ35@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
CMS3_k127_299025_6	290397.Adeh_1215	6.939e-49	190.0	COG2912@1|root,COG2912@2|Bacteria,1MVJQ@1224|Proteobacteria,43824@68525|delta/epsilon subdivisions,2X3C7@28221|Deltaproteobacteria,2YVD2@29|Myxococcales	28221|Deltaproteobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
CMS3_k127_299025_8	479434.Sthe_2006	6.199e-36	150.0	COG0432@1|root,COG1304@1|root,COG0432@2|Bacteria,COG1304@2|Bacteria,2G5RF@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
CMS3_k127_299025_14	1306174.JODP01000003_gene1860	4.756e-06	56.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD,GPDPase_memb
CMS3_k127_299025_2	479434.Sthe_2425	5.306e-60	223.0	COG1565@1|root,COG1565@2|Bacteria,2G8NS@200795|Chloroflexi,27Y3B@189775|Thermomicrobia	189775|Thermomicrobia	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
CMS3_k127_3001396_0	861299.J421_0662	3.376e-35	151.0	COG2030@1|root,COG2030@2|Bacteria	2|Bacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
CMS3_k127_3003138_17	269800.Tfu_1644	3.322e-13	77.0	COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4EFUH@85012|Streptosporangiales	201174|Actinobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
CMS3_k127_3003138_12	1123489.AUAN01000002_gene973	4.904e-28	123.0	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,4H4PX@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
CMS3_k127_3003138_7	309801.trd_A0070	5.954e-60	229.0	COG3848@1|root,COG3848@2|Bacteria	2|Bacteria	GT	kinase activity	yvkC	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
CMS3_k127_3003138_16	237368.SCABRO_00357	2.515e-13	82.0	COG2846@1|root,COG2846@2|Bacteria,2J2QY@203682|Planctomycetes	203682|Planctomycetes	D	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
CMS3_k127_3003138_14	1288484.APCS01000013_gene914	3.745e-25	110.0	COG3324@1|root,COG3324@2|Bacteria	2|Bacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
CMS3_k127_3003138_13	1121406.JAEX01000005_gene2911	8.395e-27	112.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2WRRT@28221|Deltaproteobacteria,2MCID@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS3_k127_3003138_11	1380390.JIAT01000013_gene299	2.146e-28	123.0	COG1403@1|root,COG1403@2|Bacteria,2GV0W@201174|Actinobacteria,4CQF2@84995|Rubrobacteria	84995|Rubrobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
CMS3_k127_3003138_5	1101190.ARWB01000001_gene3908	4.786e-75	268.0	COG2141@1|root,COG2141@2|Bacteria,1MWMV@1224|Proteobacteria,2TTIQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Catalyzes the desulfonation of aliphatic sulfonates	ssuD	-	1.14.14.5	ko:K04091	ko00920,map00920	-	R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
CMS3_k127_3003138_18	56780.SYN_02900	1.315e-09	71.0	COG5553@1|root,COG5553@2|Bacteria,1NI0U@1224|Proteobacteria,43160@68525|delta/epsilon subdivisions,2WWEA@28221|Deltaproteobacteria,2MS6U@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Cysteine dioxygenase type I	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3003138_10	1282876.BAOK01000002_gene207	1.408e-40	162.0	28HWH@1|root,2Z82E@2|Bacteria,1MUF7@1224|Proteobacteria,2TV8Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3003138_3	1282876.BAOK01000002_gene622	1.068e-114	376.0	COG0596@1|root,COG0596@2|Bacteria,1R4ZX@1224|Proteobacteria,2TU6R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons	dhaA	-	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_3003138_0	383372.Rcas_3335	6.805e-180	576.0	COG0318@1|root,COG0318@2|Bacteria,2G5Q8@200795|Chloroflexi,376IG@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.1.3.1,6.2.1.3	ko:K01897,ko:K22319	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
CMS3_k127_3003138_15	1196323.ALKF01000176_gene3064	9.303e-14	82.0	COG3595@1|root,COG3595@2|Bacteria,1VNYW@1239|Firmicutes,4HSHU@91061|Bacilli,26XQJ@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS3_k127_3003138_19	1380347.JNII01000006_gene1727	1.864e-06	56.0	COG4226@1|root,COG4226@2|Bacteria,2IKXB@201174|Actinobacteria,4ET5R@85013|Frankiales	201174|Actinobacteria	S	HicB family	-	-	-	-	-	-	-	-	-	-	-	-	HicB,RHH_1
CMS3_k127_3003138_9	1122603.ATVI01000009_gene2678	2.205e-43	174.0	COG3173@1|root,COG3173@2|Bacteria,1R7XK@1224|Proteobacteria	1224|Proteobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase
CMS3_k127_3003138_6	469383.Cwoe_5826	2.873e-63	228.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4CP8R@84995|Rubrobacteria	84995|Rubrobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
CMS3_k127_3003138_8	553204.CORAM0001_2150	3.53e-57	204.0	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria,22KSE@1653|Corynebacteriaceae	201174|Actinobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
CMS3_k127_3003138_4	552811.Dehly_0912	1.535e-109	368.0	COG0540@1|root,COG0540@2|Bacteria,2G6GU@200795|Chloroflexi,34D9H@301297|Dehalococcoidia	301297|Dehalococcoidia	F	amino acid binding	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS3_k127_3003138_1	243164.DET1200	4.186e-132	443.0	COG0044@1|root,COG0044@2|Bacteria,2G640@200795|Chloroflexi,34CTM@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
CMS3_k127_3003138_2	1303518.CCALI_00114	9.746e-117	388.0	COG0505@1|root,COG0505@2|Bacteria	2|Bacteria	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955,ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1383	CPSase_sm_chain,GATase
CMS3_k127_3017856_5	509191.AEDB02000063_gene452	2.445e-15	77.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,3WN0W@541000|Ruminococcaceae	186801|Clostridia	U	Type II/IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
CMS3_k127_3017856_4	1123288.SOV_2c07710	8.296e-32	138.0	COG4965@1|root,COG4965@2|Bacteria,1UZ3V@1239|Firmicutes,4H3YR@909932|Negativicutes	909932|Negativicutes	U	Type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
CMS3_k127_3017856_2	574087.Acear_0238	7.464e-37	151.0	COG2064@1|root,COG2064@2|Bacteria,1V2T1@1239|Firmicutes,24GQ4@186801|Clostridia	186801|Clostridia	NU	PFAM type II secretion system	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
CMS3_k127_3017856_7	926550.CLDAP_35680	2.982e-10	69.0	COG1989@1|root,COG1989@2|Bacteria	2|Bacteria	NOU	aspartic-type endopeptidase activity	pppA	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
CMS3_k127_3017856_6	926566.Terro_3228	2.304e-14	87.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria,2JIRN@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
CMS3_k127_3017856_8	314266.SKA58_12220	3.567e-05	56.0	COG1388@1|root,COG1388@2|Bacteria,1PEC9@1224|Proteobacteria,2URJJ@28211|Alphaproteobacteria,2K7Z3@204457|Sphingomonadales	204457|Sphingomonadales	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
CMS3_k127_3017856_3	298653.Franean1_5465	4.137e-32	138.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2I5I3@201174|Actinobacteria,4EWVP@85013|Frankiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
CMS3_k127_3017856_1	1313172.YM304_07760	7.772e-49	182.0	COG0704@1|root,COG0704@2|Bacteria,2H63V@201174|Actinobacteria	201174|Actinobacteria	P	PhoU domain	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
CMS3_k127_3017856_0	1313172.YM304_07770	9.485e-105	352.0	COG1283@1|root,COG1283@2|Bacteria,2IAMX@201174|Actinobacteria	201174|Actinobacteria	P	Na+/Pi-cotransporter	nptA	-	-	ko:K03324,ko:K14683	-	-	-	-	ko00000,ko02000,ko04147	2.A.58.1,2.A.58.2	-	-	Na_Pi_cotrans
CMS3_k127_303747_8	1330700.JQNC01000003_gene1191	5.586e-27	124.0	COG0477@1|root,COG2814@2|Bacteria,1WJC5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_303747_9	272560.BPSS2332	3.721e-22	102.0	COG2128@1|root,COG2128@2|Bacteria,1NFKC@1224|Proteobacteria,2VV05@28216|Betaproteobacteria,1K1RQ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	decarboxylase	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
CMS3_k127_303747_5	479434.Sthe_3043	6.852e-54	201.0	COG0111@1|root,COG0111@2|Bacteria	2|Bacteria	EH	4-phosphoerythronate dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS3_k127_303747_2	196162.Noca_2581	2.365e-69	263.0	COG0778@1|root,COG0778@2|Bacteria,2GKG5@201174|Actinobacteria,4DSF9@85009|Propionibacteriales	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS3_k127_303747_4	1111728.ATYS01000001_gene2413	4.129e-62	224.0	COG2227@1|root,COG2227@2|Bacteria,1QYHT@1224|Proteobacteria,1T3QK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_303747_6	485913.Krac_4790	1.066e-35	146.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_303747_10	1282360.ABAC460_10305	2.755e-14	76.0	COG0346@1|root,COG0346@2|Bacteria,1RHRF@1224|Proteobacteria	1224|Proteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_303747_3	1206720.BAFQ01000281_gene5906	1.26e-67	241.0	COG2220@1|root,COG2220@2|Bacteria,2IT2Z@201174|Actinobacteria,4FXF0@85025|Nocardiaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_3
CMS3_k127_303747_0	1313172.YM304_01170	3.586e-127	421.0	COG1804@1|root,COG1804@2|Bacteria,2GKDI@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_303747_7	876269.ARWA01000001_gene2973	1.328e-31	130.0	COG5507@1|root,COG5507@2|Bacteria,1RH3Q@1224|Proteobacteria,2U9SM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM NIPSNAP family containing protein	MA20_41850	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
CMS3_k127_303747_1	1289387.AUKW01000003_gene2221	1.36e-94	318.0	COG1028@1|root,COG1028@2|Bacteria,2GWHQ@201174|Actinobacteria	201174|Actinobacteria	IQ	short-chain dehydrogenase reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
CMS3_k127_3039487_0	234267.Acid_5780	3.607e-59	226.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,TPR_8,Trans_reg_C
CMS3_k127_3053393_8	456442.Mboo_0005	8.115e-21	94.0	COG2835@1|root,arCOG04124@2157|Archaea,2XZRS@28890|Euryarchaeota,2NA4S@224756|Methanomicrobia	224756|Methanomicrobia	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
CMS3_k127_3053393_5	497321.C664_16008	2.728e-34	141.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2VU9G@28216|Betaproteobacteria,2KWFV@206389|Rhodocyclales	206389|Rhodocyclales	S	CoA-binding protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
CMS3_k127_3053393_7	316274.Haur_0682	2.133e-32	141.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,NUDIX
CMS3_k127_3053393_0	552811.Dehly_0397	3.491e-170	554.0	COG0034@1|root,COG0034@2|Bacteria,2G61T@200795|Chloroflexi,34CJ3@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
CMS3_k127_3053393_3	317619.ANKN01000117_gene1333	1.544e-83	292.0	COG0150@1|root,COG0150@2|Bacteria,1G1WY@1117|Cyanobacteria,1MKTW@1212|Prochloraceae	1117|Cyanobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
CMS3_k127_3053393_1	243164.DET1417	7.895e-151	493.0	COG0138@1|root,COG0138@2|Bacteria,2G5JG@200795|Chloroflexi,34CRG@301297|Dehalococcoidia	301297|Dehalococcoidia	F	AICARFT/IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
CMS3_k127_3053393_4	1035308.AQYY01000001_gene1561	7.303e-76	262.0	COG1215@1|root,COG1215@2|Bacteria,1TPBB@1239|Firmicutes,25E7R@186801|Clostridia,261MQ@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_3053393_2	886293.Sinac_1830	4.365e-107	353.0	COG1290@1|root,COG1290@2|Bacteria,2IX3Q@203682|Planctomycetes	203682|Planctomycetes	C	Domain of unknown function (DUF4405)	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B
CMS3_k127_3053393_6	1123242.JH636438_gene5694	6.351e-34	135.0	COG1290@1|root,COG1290@2|Bacteria,2IYI0@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
CMS3_k127_3068545_0	1144275.COCOR_04589	0.0003489	51.0	COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,42QH5@68525|delta/epsilon subdivisions,2WMMF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	response regulator	colR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_3068545_1	68219.JNXI01000009_gene3531	0.0007585	46.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system protein e	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
CMS3_k127_3087317_1	1123504.JQKD01000012_gene1285	1.032e-21	104.0	COG1804@1|root,COG1804@2|Bacteria,1NSWZ@1224|Proteobacteria,2VPQF@28216|Betaproteobacteria	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_3087317_0	1125973.JNLC01000010_gene1156	6.383e-22	108.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,3JSEP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_3089902_7	1121430.JMLG01000001_gene2115	1.027e-16	87.0	COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,24M2Q@186801|Clostridia,261QR@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4115)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
CMS3_k127_3089902_4	1111131.HMPREF1255_1828	7.865e-69	250.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4DRH1@85009|Propionibacteriales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_3089902_8	1382306.JNIM01000001_gene3758	1.432e-09	63.0	COG0268@1|root,COG0268@2|Bacteria,2G7AK@200795|Chloroflexi	200795|Chloroflexi	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
CMS3_k127_3089902_1	926550.CLDAP_01110	1.125e-99	345.0	COG0728@1|root,COG0728@2|Bacteria,2G5MD@200795|Chloroflexi	200795|Chloroflexi	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
CMS3_k127_3089902_6	479434.Sthe_2339	2.112e-32	135.0	COG1278@1|root,COG1278@2|Bacteria,2G79W@200795|Chloroflexi,27YHA@189775|Thermomicrobia	189775|Thermomicrobia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
CMS3_k127_3089902_2	44060.JODL01000014_gene3682	1.891e-97	327.0	COG3173@1|root,COG3173@2|Bacteria,2GKUU@201174|Actinobacteria	201174|Actinobacteria	K	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS3_k127_3089902_0	926569.ANT_22850	0.0	1065.0	COG0060@1|root,COG0060@2|Bacteria,2G5SN@200795|Chloroflexi	200795|Chloroflexi	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
CMS3_k127_3089902_3	68223.JNZY01000062_gene1108	1.149e-81	293.0	COG3848@1|root,COG3848@2|Bacteria,2IE61@201174|Actinobacteria	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
CMS3_k127_3089902_5	290340.AAur_pTC20182	3.389e-42	159.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,1W96K@1268|Micrococcaceae	201174|Actinobacteria	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
CMS3_k127_3099866_5	309801.trd_0649	1.026e-38	149.0	COG0341@1|root,COG0341@2|Bacteria,2G696@200795|Chloroflexi,27Y1D@189775|Thermomicrobia	189775|Thermomicrobia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
CMS3_k127_3099866_1	324602.Caur_0243	3.091e-157	519.0	COG3276@1|root,COG3276@2|Bacteria,2G5JX@200795|Chloroflexi,3770N@32061|Chloroflexia	32061|Chloroflexia	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
CMS3_k127_3099866_3	1382306.JNIM01000001_gene3511	8.472e-99	336.0	COG0635@1|root,COG0635@2|Bacteria,2G5NK@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS3_k127_3099866_0	552811.Dehly_0682	3.74e-207	666.0	COG0173@1|root,COG0173@2|Bacteria,2G5RX@200795|Chloroflexi,34CSB@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
CMS3_k127_3099866_2	552811.Dehly_0558	3.09e-108	370.0	COG4166@1|root,COG4166@2|Bacteria,2G5TA@200795|Chloroflexi,34CV3@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
CMS3_k127_3099866_4	1305735.JAFT01000005_gene3572	5.686e-59	216.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRH6@28211|Alphaproteobacteria,2PDVK@252301|Oceanicola	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	MA20_32335	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS3_k127_3135360_1	492774.JQMB01000003_gene2865	8.188e-15	83.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,1MVV0@1224|Proteobacteria,2TS0V@28211|Alphaproteobacteria,4B8G6@82115|Rhizobiaceae	28211|Alphaproteobacteria	CO	Cytochrome c biogenesis protein	dipZ	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD,Redoxin
CMS3_k127_3135360_0	1128421.JAGA01000001_gene2460	1.589e-26	121.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	ccmG	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
CMS3_k127_3140263_28	1429916.X566_23700	2.059e-34	139.0	COG2021@1|root,COG2021@2|Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	rutD	GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0017144,GO:0019740,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.1.1.24,3.4.11.5,4.1.1.44	ko:K01055,ko:K01259,ko:K09023,ko:K14727,ko:K16434	ko00240,ko00330,ko00362,ko01055,ko01100,ko01120,ko01220,map00240,map00330,map00362,map01055,map01100,map01120,map01220	M00568	R00135,R02991,R03470,R09983	RC00825,RC00938,RC02769	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iEC55989_1330.EC55989_1120,iECO26_1355.ECO26_1247,iECUMN_1333.ECUMN_1192,iSF_1195.SF1012,iSFxv_1172.SFxv_1098,iSSON_1240.SSON_1027,iS_1188.S1082,ic_1306.c1146	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,CMD
CMS3_k127_3140263_15	1125863.JAFN01000001_gene580	2.314e-66	240.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,42N0M@68525|delta/epsilon subdivisions,2WJ7D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	TIGRFAM Tyrosine recombinase XerD	xerD	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS3_k127_3140263_23	1205680.CAKO01000007_gene4216	5.024e-43	170.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria,2JS4I@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes a trans-dehydration via an enolate intermediate	-	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
CMS3_k127_3140263_10	498761.HM1_0270	8.357e-92	314.0	COG0006@1|root,COG0757@1|root,COG0006@2|Bacteria,COG0757@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia	186801|Clostridia	E	creatinase	pepP	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
CMS3_k127_3140263_19	525904.Tter_1660	4.19e-56	203.0	COG0231@1|root,COG0231@2|Bacteria,2NPID@2323|unclassified Bacteria	2|Bacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
CMS3_k127_3140263_11	1122925.KB895379_gene2285	5.706e-88	304.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,4HAN2@91061|Bacilli,26QBK@186822|Paenibacillaceae	91061|Bacilli	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
CMS3_k127_3140263_33	1415779.JOMH01000001_gene1761	1.025e-06	55.0	COG1722@1|root,COG1722@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease VII activity	xseB	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
CMS3_k127_3140263_18	243164.DET0712	2.529e-58	212.0	COG0299@1|root,COG0299@2|Bacteria,2GANQ@200795|Chloroflexi,34CW6@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Formyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Formyl_trans_N
CMS3_k127_3140263_16	1485543.JMME01000001_gene1460	6.992e-59	213.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,4H2PG@909932|Negativicutes	909932|Negativicutes	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS3_k127_3140263_22	1125779.HMPREF1219_00508	2.351e-45	173.0	COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,22JQT@1653|Corynebacteriaceae	201174|Actinobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0040007,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
CMS3_k127_3140263_27	1382356.JQMP01000003_gene2415	3.242e-35	144.0	COG0204@1|root,COG0204@2|Bacteria,2G78P@200795|Chloroflexi,27Y83@189775|Thermomicrobia	189775|Thermomicrobia	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS3_k127_3140263_3	338966.Ppro_0093	2.272e-175	571.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,43TNF@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
CMS3_k127_3140263_0	880073.Calab_2574	0.0	1125.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2NNNY@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS3_k127_3140263_9	243164.DET0553	1.006e-104	355.0	COG0232@1|root,COG0232@2|Bacteria,2G5VZ@200795|Chloroflexi,34CSV@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Phosphohydrolase-associated domain	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
CMS3_k127_3140263_7	479434.Sthe_0414	8.491e-112	385.0	COG0358@1|root,COG0358@2|Bacteria,2G65X@200795|Chloroflexi,27XKY@189775|Thermomicrobia	189775|Thermomicrobia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
CMS3_k127_3140263_5	311424.DhcVS_491	6.245e-137	454.0	COG0568@1|root,COG0568@2|Bacteria,2G5W3@200795|Chloroflexi,34D2Y@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS3_k127_3140263_26	552811.Dehly_1579	2.379e-35	145.0	COG4478@1|root,COG4478@2|Bacteria,2G9EA@200795|Chloroflexi,34CJ2@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Protein of unknown function (DUF1461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1461
CMS3_k127_3140263_21	292459.STH3231	9.38e-48	184.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia	186801|Clostridia	K	TIGRFAM MazG family protein	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
CMS3_k127_3140263_29	479434.Sthe_0127	8.39e-20	98.0	COG0526@1|root,COG0526@2|Bacteria,2G8YT@200795|Chloroflexi,27YFH@189775|Thermomicrobia	200795|Chloroflexi	CO	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_9
CMS3_k127_3140263_25	326427.Cagg_2942	2.622e-37	148.0	COG0143@1|root,COG0143@2|Bacteria,2G6VG@200795|Chloroflexi,375Q2@32061|Chloroflexia	32061|Chloroflexia	J	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
CMS3_k127_3140263_2	311424.DhcVS_979	5.208e-209	674.0	COG0210@1|root,COG0210@2|Bacteria,2G5XF@200795|Chloroflexi,34D7Z@301297|Dehalococcoidia	301297|Dehalococcoidia	L	UvrD/REP helicase N-terminal domain	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
CMS3_k127_3140263_12	479434.Sthe_0724	5.119e-79	282.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2G5WG@200795|Chloroflexi,27XRJ@189775|Thermomicrobia	189775|Thermomicrobia	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
CMS3_k127_3140263_30	110663.KI911558_gene108	1.389e-09	68.0	COG0857@1|root,COG0857@2|Bacteria,1G0QB@1117|Cyanobacteria,1GZVA@1129|Synechococcus	1117|Cyanobacteria	C	BioD-like N-terminal domain of phosphotransacetylase	pta	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
CMS3_k127_3140263_6	298653.Franean1_6797	8.183e-126	432.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4ESAG@85013|Frankiales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994,ko:K20470	-	-	-	-	ko00000,ko02000	2.A.6.5.6	-	-	MMPL
CMS3_k127_3140263_1	314230.DSM3645_19883	1.298e-210	667.0	COG0069@1|root,COG0069@2|Bacteria,2J28V@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the glutamate synthase family	-	-	2.1.1.21	ko:K22083	ko00680,ko01120,map00680,map01120	-	R01586	RC00554	ko00000,ko00001,ko01000	-	-	-	Glu_synthase
CMS3_k127_3140263_13	761193.Runsl_5032	1.135e-72	254.0	COG3484@1|root,COG3484@2|Bacteria,4NGR7@976|Bacteroidetes,47MX7@768503|Cytophagia	976|Bacteroidetes	O	Proteasome subunit	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	Proteasome
CMS3_k127_3140263_24	517417.Cpar_0769	4.997e-42	164.0	COG1305@1|root,COG1305@2|Bacteria,1FEB8@1090|Chlorobi	1090|Chlorobi	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
CMS3_k127_3140263_17	388467.A19Y_3175	1.339e-58	215.0	COG2307@1|root,COG2307@2|Bacteria,1G05F@1117|Cyanobacteria,1H8SU@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Bacterial domain of	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
CMS3_k127_3140263_4	290318.Cvib_1220	6.383e-161	520.0	COG2308@1|root,COG2308@2|Bacteria,1FDTV@1090|Chlorobi	1090|Chlorobi	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
CMS3_k127_3140263_20	929562.Emtol_3680	1.047e-52	198.0	COG2755@1|root,COG2755@2|Bacteria,4NNIC@976|Bacteroidetes,47PEW@768503|Cytophagia	976|Bacteroidetes	E	PFAM GDSL-like Lipase Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS3_k127_3140263_8	551789.ATVJ01000001_gene2146	3.359e-109	366.0	COG2267@1|root,COG2267@2|Bacteria,1QU7K@1224|Proteobacteria,2TW27@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	2.7.10.2,3.3.2.9	ko:K01253,ko:K08253	ko00980,ko04976,ko05204,map00980,map04976,map05204	-	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443	RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
CMS3_k127_3140263_14	251221.35210658	2.879e-69	244.0	COG0488@1|root,COG0488@2|Bacteria,1G14R@1117|Cyanobacteria	1117|Cyanobacteria	S	of ABC transporters with duplicated ATPase	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
CMS3_k127_3163142_3	1380387.JADM01000003_gene2659	5.389e-78	272.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1XIV4@135619|Oceanospirillales	135619|Oceanospirillales	P	(ABC) transporter, permease	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS3_k127_3163142_9	518766.Rmar_1502	2.773e-35	152.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,4NE05@976|Bacteroidetes,1FK03@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS3_k127_3163142_4	324602.Caur_3876	1.096e-74	265.0	COG1195@1|root,COG1195@2|Bacteria,2G60N@200795|Chloroflexi,375E0@32061|Chloroflexia	32061|Chloroflexia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
CMS3_k127_3163142_8	383372.Rcas_2259	1.256e-43	171.0	COG1597@1|root,COG1597@2|Bacteria,2G70R@200795|Chloroflexi,375F4@32061|Chloroflexia	32061|Chloroflexia	I	diacylglycerol kinase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
CMS3_k127_3163142_5	1137269.AZWL01000001_gene5345	9.691e-70	248.0	COG0346@1|root,COG0346@2|Bacteria,2I9RU@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
CMS3_k127_3163142_12	316274.Haur_0571	1.805e-20	98.0	2CMS6@1|root,32SFE@2|Bacteria,2G905@200795|Chloroflexi	200795|Chloroflexi	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS3_k127_3163142_6	1123372.AUIT01000007_gene485	7.195e-63	228.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,2GH0E@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
CMS3_k127_3163142_0	479434.Sthe_3486	2.194e-190	620.0	COG4867@1|root,COG4867@2|Bacteria,2G8A6@200795|Chloroflexi,27XPF@189775|Thermomicrobia	189775|Thermomicrobia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3163142_1	309801.trd_A0505	5.045e-184	586.0	COG1239@1|root,COG1239@2|Bacteria,2GB7G@200795|Chloroflexi,27XRK@189775|Thermomicrobia	189775|Thermomicrobia	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	-
CMS3_k127_3163142_7	405948.SACE_1969	2.732e-50	184.0	COG1670@1|root,COG1670@2|Bacteria,2H4AD@201174|Actinobacteria,4E4W2@85010|Pseudonocardiales	201174|Actinobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3163142_13	697281.Mahau_2933	8.862e-07	55.0	COG1476@1|root,COG1476@2|Bacteria,1VEKB@1239|Firmicutes,25EYA@186801|Clostridia	186801|Clostridia	K	transcriptional regulator, XRE family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
CMS3_k127_3163142_2	1382356.JQMP01000004_gene673	2.062e-134	450.0	COG0001@1|root,COG0001@2|Bacteria,2G7UK@200795|Chloroflexi,27XN6@189775|Thermomicrobia	189775|Thermomicrobia	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_3163142_10	1487953.JMKF01000044_gene2999	2.076e-26	111.0	COG2154@1|root,COG2154@2|Bacteria,1G7P9@1117|Cyanobacteria,1HCM2@1150|Oscillatoriales	1117|Cyanobacteria	H	PFAM Pterin 4 alpha carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
CMS3_k127_3163142_11	1172188.KB911822_gene932	2.902e-22	97.0	COG2041@1|root,COG2041@2|Bacteria,2GIZH@201174|Actinobacteria,4FI2F@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
CMS3_k127_3166026_0	2074.JNYD01000014_gene7030	3.07e-119	391.0	COG0604@1|root,COG0604@2|Bacteria,2GRJM@201174|Actinobacteria,4DZWE@85010|Pseudonocardiales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
CMS3_k127_3166026_2	68219.JNXI01000002_gene4186	2.771e-72	252.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	resD	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_3166026_6	316274.Haur_4664	4.232e-54	206.0	COG0642@1|root,COG2205@2|Bacteria,2GBIY@200795|Chloroflexi	200795|Chloroflexi	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_3166026_4	1380387.JADM01000002_gene2121	1.016e-66	235.0	COG0346@1|root,COG0346@2|Bacteria,1MW8Z@1224|Proteobacteria,1SPM3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
CMS3_k127_3166026_5	1380387.JADM01000002_gene2121	1.016e-66	235.0	COG0346@1|root,COG0346@2|Bacteria,1MW8Z@1224|Proteobacteria,1SPM3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
CMS3_k127_3166026_7	316274.Haur_4664	4.232e-54	206.0	COG0642@1|root,COG2205@2|Bacteria,2GBIY@200795|Chloroflexi	200795|Chloroflexi	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_3166026_3	68219.JNXI01000002_gene4186	2.771e-72	252.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	resD	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_3166026_1	2074.JNYD01000014_gene7030	3.07e-119	391.0	COG0604@1|root,COG0604@2|Bacteria,2GRJM@201174|Actinobacteria,4DZWE@85010|Pseudonocardiales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
CMS3_k127_3176356_3	1089548.KI783301_gene2787	7.91e-58	216.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,4HAGN@91061|Bacilli,3WG2H@539002|Bacillales incertae sedis	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_3176356_2	886293.Sinac_2964	3.607e-59	228.0	COG3622@1|root,COG3622@2|Bacteria,2J4Z5@203682|Planctomycetes	203682|Planctomycetes	G	PFAM Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS3_k127_3176356_0	479434.Sthe_0459	1.174e-179	584.0	COG0480@1|root,COG0480@2|Bacteria,2G680@200795|Chloroflexi,27XJI@189775|Thermomicrobia	189775|Thermomicrobia	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS3_k127_3176356_1	1089544.KB912942_gene4161	1.833e-164	541.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_3184967_2	298654.FraEuI1c_6402	2.521e-114	378.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,4EU7M@85013|Frankiales	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_3184967_1	1205680.CAKO01000037_gene1250	3.037e-134	439.0	COG2141@1|root,COG2141@2|Bacteria,1NKS6@1224|Proteobacteria,2TT87@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_3184967_0	1536773.R70331_20600	1.145e-183	592.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,4H9ZF@91061|Bacilli,26QJT@186822|Paenibacillaceae	91061|Bacilli	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
CMS3_k127_3184967_5	1382356.JQMP01000003_gene2027	5.224e-62	221.0	COG0412@1|root,COG0412@2|Bacteria,2G9WC@200795|Chloroflexi,27Z94@189775|Thermomicrobia	189775|Thermomicrobia	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
CMS3_k127_3184967_7	396595.TK90_2294	2.521e-12	75.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,1SDVD@1236|Gammaproteobacteria,1WZPY@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
CMS3_k127_3184967_6	196367.JNFG01000214_gene1275	2.818e-50	189.0	COG0596@1|root,COG0596@2|Bacteria,1N3G3@1224|Proteobacteria,2WH3B@28216|Betaproteobacteria,1KIHJ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_3184967_4	1303518.CCALI_01253	7.017e-69	256.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin,Thioredoxin
CMS3_k127_3184967_3	502025.Hoch_5408	6.921e-107	366.0	COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2WJ2C@28221|Deltaproteobacteria,2YTZK@29|Myxococcales	28221|Deltaproteobacteria	CE	Peptidase family M1 domain	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,HEAT_2,Peptidase_M1
CMS3_k127_3293800_2	1068980.ARVW01000001_gene5979	5.382e-20	103.0	COG1670@1|root,COG1670@2|Bacteria,2HH1T@201174|Actinobacteria,4EBJV@85010|Pseudonocardiales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
CMS3_k127_3293800_5	262724.TT_C0031	1.021e-05	56.0	28TIQ@1|root,2ZFSJ@2|Bacteria,1WK1S@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3293800_3	547163.BN979_02970	1.625e-19	94.0	COG0599@1|root,COG0599@2|Bacteria,2IM8G@201174|Actinobacteria,239Q5@1762|Mycobacteriaceae	201174|Actinobacteria	S	decarboxylase	pcaC	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
CMS3_k127_3293800_0	420324.KI912037_gene2397	1.449e-60	226.0	COG1073@1|root,COG2114@1|root,COG1073@2|Bacteria,COG2114@2|Bacteria,1QWKB@1224|Proteobacteria,2TX0H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,GerE,Guanylate_cyc,Hydrolase_4
CMS3_k127_3293800_4	926550.CLDAP_34140	1.378e-11	74.0	COG2304@1|root,COG2304@2|Bacteria,2G7VX@200795|Chloroflexi	200795|Chloroflexi	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA
CMS3_k127_3308566_14	502558.EGYY_10880	1.238e-33	136.0	COG0125@1|root,COG0125@2|Bacteria,2GNTI@201174|Actinobacteria,4CVPV@84998|Coriobacteriia	84998|Coriobacteriia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
CMS3_k127_3308566_1	357808.RoseRS_3233	1.423e-175	568.0	COG1847@1|root,COG3854@1|root,COG1847@2|Bacteria,COG3854@2|Bacteria,2G5P5@200795|Chloroflexi,375BX@32061|Chloroflexia	32061|Chloroflexia	S	PFAM single-stranded nucleic acid binding R3H domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA,R3H
CMS3_k127_3308566_7	222534.KB893671_gene3240	8.107e-64	228.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4ESCW@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
CMS3_k127_3308566_2	1128421.JAGA01000002_gene682	9.114e-126	412.0	COG0214@1|root,COG0214@2|Bacteria,2NNZ6@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
CMS3_k127_3308566_16	298654.FraEuI1c_2849	1.628e-27	125.0	COG0622@1|root,COG0622@2|Bacteria	2|Bacteria	S	retrograde transport, endosome to Golgi	ysnB	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
CMS3_k127_3308566_17	298655.KI912266_gene5478	3.709e-23	111.0	COG3206@1|root,COG3206@2|Bacteria,2GPMH@201174|Actinobacteria,4EWJJ@85013|Frankiales	201174|Actinobacteria	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
CMS3_k127_3308566_20	485913.Krac_8186	6.616e-17	87.0	COG0589@1|root,COG0589@2|Bacteria,2G7D7@200795|Chloroflexi	200795|Chloroflexi	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_3308566_13	1382306.JNIM01000001_gene386	3.986e-36	141.0	COG0569@1|root,COG0569@2|Bacteria,2G71A@200795|Chloroflexi	200795|Chloroflexi	C	PFAM TrkA-N domain protein	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_N
CMS3_k127_3308566_10	1122939.ATUD01000004_gene3716	5.82e-49	192.0	COG0569@1|root,COG0569@2|Bacteria,2GKB9@201174|Actinobacteria,4CPKV@84995|Rubrobacteria	84995|Rubrobacteria	P	Putative NAD(P)-binding	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS3_k127_3308566_5	1128421.JAGA01000002_gene1561	8.355e-69	243.0	COG0077@1|root,COG0077@2|Bacteria,2NR2C@2323|unclassified Bacteria	2|Bacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
CMS3_k127_3308566_11	656519.Halsa_1750	4.127e-43	168.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,3WAJM@53433|Halanaerobiales	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
CMS3_k127_3308566_9	316274.Haur_4220	2.675e-53	195.0	COG1403@1|root,COG1403@2|Bacteria,2G6WV@200795|Chloroflexi,375TQ@32061|Chloroflexia	32061|Chloroflexia	L	SMART HNH nuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
CMS3_k127_3308566_22	1122164.JHWF01000044_gene1413	0.0001785	51.0	COG1286@1|root,COG1286@2|Bacteria,1N45N@1224|Proteobacteria,1SAE0@1236|Gammaproteobacteria,1JCS2@118969|Legionellales	118969|Legionellales	S	Colicin V production protein	dedE	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
CMS3_k127_3308566_6	765420.OSCT_1624	3.432e-67	237.0	COG2003@1|root,COG2003@2|Bacteria,2G6BK@200795|Chloroflexi,375AQ@32061|Chloroflexia	32061|Chloroflexia	L	PFAM DNA repair protein RadC	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
CMS3_k127_3308566_12	644966.Tmar_2304	9.155e-40	151.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia,3WD9N@538999|Clostridiales incertae sedis	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
CMS3_k127_3308566_15	309801.trd_0683	3.667e-29	127.0	COG0244@1|root,COG0244@2|Bacteria,2G6XJ@200795|Chloroflexi,27YC4@189775|Thermomicrobia	189775|Thermomicrobia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
CMS3_k127_3308566_3	1410612.JNKO01000002_gene2246	6.44e-76	262.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,247JB@186801|Clostridia,2PQVJ@265975|Oribacterium	186801|Clostridia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
CMS3_k127_3308566_8	479434.Sthe_1607	3.086e-56	199.0	COG0080@1|root,COG0080@2|Bacteria,2G6FF@200795|Chloroflexi,27Y72@189775|Thermomicrobia	189775|Thermomicrobia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
CMS3_k127_3308566_4	644966.Tmar_2308	7.298e-69	239.0	COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,248XB@186801|Clostridia,3WCHU@538999|Clostridiales incertae sedis	186801|Clostridia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
CMS3_k127_3308566_21	243164.DET0995	1.143e-08	61.0	COG0690@1|root,COG0690@2|Bacteria,2G9VX@200795|Chloroflexi,34DH3@301297|Dehalococcoidia	301297|Dehalococcoidia	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
CMS3_k127_3308566_19	767029.HMPREF9154_2318	4.007e-17	83.0	COG0267@1|root,COG0267@2|Bacteria,2GQFG@201174|Actinobacteria,4DS40@85009|Propionibacteriales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
CMS3_k127_3308566_0	479434.Sthe_1611	8.672e-209	655.0	COG0050@1|root,COG0050@2|Bacteria,2G5KI@200795|Chloroflexi,27XXD@189775|Thermomicrobia	189775|Thermomicrobia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	-	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
CMS3_k127_3308566_18	604331.AUHY01000054_gene1213	2.36e-18	89.0	COG0215@1|root,COG0215@2|Bacteria,1WIEP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
CMS3_k127_3348441_0	926550.CLDAP_06490	2.658e-195	622.0	COG1529@1|root,COG1529@2|Bacteria,2G65D@200795|Chloroflexi	200795|Chloroflexi	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS3_k127_3348441_4	926550.CLDAP_06500	9.127e-67	230.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi	200795|Chloroflexi	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CMS3_k127_3348441_3	314230.DSM3645_02368	3.098e-71	254.0	COG1319@1|root,COG1319@2|Bacteria,2IYV7@203682|Planctomycetes	203682|Planctomycetes	C	COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM CutM homologs	-	-	1.17.1.4,1.2.5.3	ko:K03519,ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
CMS3_k127_3348441_12	1283299.AUKG01000002_gene4592	8.362e-21	105.0	COG1983@1|root,COG1983@2|Bacteria,2HP86@201174|Actinobacteria,4CQKI@84995|Rubrobacteria	84995|Rubrobacteria	KT	PspC domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
CMS3_k127_3348441_16	994479.GL877878_gene2464	1.47e-07	64.0	COG3871@1|root,COG3871@2|Bacteria,2I2QZ@201174|Actinobacteria,4E4E6@85010|Pseudonocardiales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_3348441_18	1157632.AQWQ01000014_gene3529	1.856e-05	56.0	2DPU0@1|root,333DA@2|Bacteria,2IARZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3348441_13	1122939.ATUD01000005_gene2632	4.963e-17	89.0	COG1989@1|root,COG1989@2|Bacteria,2GJ7K@201174|Actinobacteria,4CQAS@84995|Rubrobacteria	84995|Rubrobacteria	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
CMS3_k127_3348441_11	323850.Shew_0641	2.119e-21	99.0	COG1430@1|root,COG1430@2|Bacteria,1N7U4@1224|Proteobacteria,1T8QK@1236|Gammaproteobacteria,2QCDE@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
CMS3_k127_3348441_6	110319.CF8_2741	3.536e-42	168.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,4DR34@85009|Propionibacteriales	201174|Actinobacteria	NU	Type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
CMS3_k127_3348441_7	555088.DealDRAFT_3016	4.803e-34	145.0	COG4965@1|root,COG4965@2|Bacteria,1UZ3V@1239|Firmicutes,25D46@186801|Clostridia,42KGJ@68298|Syntrophomonadaceae	186801|Clostridia	U	PFAM type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
CMS3_k127_3348441_2	574087.Acear_0236	2.498e-149	484.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia	186801|Clostridia	U	Type II IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
CMS3_k127_3348441_5	1089553.Tph_c05490	3.503e-59	220.0	COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,1UF2S@1239|Firmicutes,248CD@186801|Clostridia,42FVJ@68295|Thermoanaerobacterales	186801|Clostridia	D	ATPase MipZ	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,Response_reg
CMS3_k127_3348441_10	635013.TherJR_2811	5.265e-22	106.0	COG3745@1|root,COG3745@2|Bacteria,1V5FZ@1239|Firmicutes,24I7V@186801|Clostridia,262WB@186807|Peptococcaceae	186801|Clostridia	U	Flp pilus assembly protein RcpC/CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
CMS3_k127_3348441_17	644966.Tmar_1212	4.038e-07	60.0	COG4961@1|root,COG4961@2|Bacteria,1VFNR@1239|Firmicutes,24R06@186801|Clostridia,3WDPM@538999|Clostridiales incertae sedis	186801|Clostridia	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
CMS3_k127_3348441_19	13616.ENSMODP00000012793	7.664e-05	55.0	COG2214@1|root,KOG0691@2759|Eukaryota,39SD2@33154|Opisthokonta,3BMNM@33208|Metazoa,3D542@33213|Bilateria,48CFM@7711|Chordata,498H3@7742|Vertebrata,3JEXW@40674|Mammalia,4K8Z5@9263|Metatheria	33208|Metazoa	O	DnaJ (Hsp40) homolog, subfamily C, member 4	DNAJC4	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0006457,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0016020,GO:0035966,GO:0042221,GO:0050896,GO:0051082	-	ko:K09524	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ
CMS3_k127_3348441_15	1293047.CBMA010000030_gene2149	9.309e-09	68.0	COG2304@1|root,arCOG07561@1|root,arCOG02902@2157|Archaea,arCOG07561@2157|Archaea,2XVVH@28890|Euryarchaeota,23SGN@183963|Halobacteria	183963|Halobacteria	K	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
CMS3_k127_3348441_9	585531.HMPREF0063_11575	1.855e-23	108.0	COG1595@1|root,COG1595@2|Bacteria,2GJER@201174|Actinobacteria,4DPVS@85009|Propionibacteriales	201174|Actinobacteria	K	ECF sigma factor	adsA	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3348441_8	479434.Sthe_0585	5.67e-28	123.0	COG3764@1|root,COG3764@2|Bacteria,2G77W@200795|Chloroflexi,27YHD@189775|Thermomicrobia	189775|Thermomicrobia	M	peptidase C60 sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
CMS3_k127_3348441_14	935948.KE386494_gene568	3.972e-11	74.0	COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24I20@186801|Clostridia,42GCV@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM SCP-like extracellular	-	-	-	-	-	-	-	-	-	-	-	-	CAP
CMS3_k127_3348441_1	450851.PHZ_c1807	6.23e-188	598.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,2KIUB@204458|Caulobacterales	204458|Caulobacterales	C	Flavin-binding monooxygenase-like	-	-	1.14.13.84	ko:K14520	ko00363,ko01100,ko01120,map00363,map01100,map01120	-	R06892	RC01644	ko00000,ko00001,ko01000	-	-	-	-
CMS3_k127_3365587_3	1449346.JQMO01000003_gene2557	8.439e-10	67.0	COG0645@1|root,COG0645@2|Bacteria,2IGXB@201174|Actinobacteria	201174|Actinobacteria	Q	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
CMS3_k127_3365587_0	552811.Dehly_0308	6.274e-109	365.0	COG0263@1|root,COG0263@2|Bacteria,2G67X@200795|Chloroflexi,34CYZ@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
CMS3_k127_3365587_2	326297.Sama_3404	4.102e-19	100.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,2Q9Y9@267890|Shewanellaceae	1236|Gammaproteobacteria	S	UPF0761 membrane protein	rbn	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
CMS3_k127_3365587_4	381666.H16_A1246	2.64e-07	60.0	COG4319@1|root,COG4319@2|Bacteria,1NDE4@1224|Proteobacteria,2VY1F@28216|Betaproteobacteria,1K7XV@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
CMS3_k127_3365587_1	216594.MMAR_3505	1.569e-59	222.0	COG0596@1|root,COG2114@1|root,COG0596@2|Bacteria,COG2114@2|Bacteria,2IASU@201174|Actinobacteria,232FZ@1762|Mycobacteriaceae	201174|Actinobacteria	IT	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
CMS3_k127_3379781_15	765420.OSCT_2772	1.135e-22	106.0	COG2001@1|root,COG2001@2|Bacteria,2G6ZC@200795|Chloroflexi,3778H@32061|Chloroflexia	32061|Chloroflexia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
CMS3_k127_3379781_8	255470.cbdbA281	6.747e-91	309.0	COG0275@1|root,COG0275@2|Bacteria,2G658@200795|Chloroflexi,34CIZ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	mraW	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
CMS3_k127_3379781_5	525904.Tter_1614	3.67e-93	328.0	COG0768@1|root,COG0768@2|Bacteria,2NNWR@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	iSSON_1240.SSON_0092	PASTA,PBP_dimer,Transpeptidase
CMS3_k127_3379781_9	926569.ANT_23340	1.2e-90	316.0	COG0770@1|root,COG0770@2|Bacteria,2G5PN@200795|Chloroflexi	200795|Chloroflexi	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS3_k127_3379781_4	525904.Tter_1612	6.106e-94	324.0	COG0472@1|root,COG0472@2|Bacteria,2NNQW@2323|unclassified Bacteria	2|Bacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Glycos_transf_4,MraY_sig1
CMS3_k127_3379781_10	926569.ANT_23360	6.589e-87	310.0	COG0771@1|root,COG0771@2|Bacteria,2G5VE@200795|Chloroflexi	200795|Chloroflexi	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
CMS3_k127_3379781_6	1089553.Tph_c12630	5.855e-93	322.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,42EPV@68295|Thermoanaerobacterales	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
CMS3_k127_3379781_11	324602.Caur_0755	8.544e-64	245.0	COG0707@1|root,COG0707@2|Bacteria,2G6EH@200795|Chloroflexi,374ZS@32061|Chloroflexia	32061|Chloroflexia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
CMS3_k127_3379781_7	568816.Acin_1526	1.636e-91	322.0	COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,4H1VH@909932|Negativicutes	909932|Negativicutes	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N,Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS3_k127_3379781_3	1382306.JNIM01000001_gene3774	8.972e-106	361.0	COG1181@1|root,COG1181@2|Bacteria,2G5RS@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
CMS3_k127_3379781_16	548476.cauri_1665	1.555e-10	72.0	COG1589@1|root,COG1589@2|Bacteria,2H4A4@201174|Actinobacteria,22MQI@1653|Corynebacteriaceae	201174|Actinobacteria	D	Cell division protein FtsQ	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
CMS3_k127_3379781_2	383372.Rcas_1088	4.763e-115	385.0	COG0849@1|root,COG0849@2|Bacteria,2G5V5@200795|Chloroflexi,3757J@32061|Chloroflexia	32061|Chloroflexia	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
CMS3_k127_3379781_1	292459.STH1219	5.581e-120	404.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
CMS3_k127_3379781_13	485913.Krac_10932	1.786e-39	158.0	COG1327@1|root,COG1327@2|Bacteria,2G6QI@200795|Chloroflexi	200795|Chloroflexi	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
CMS3_k127_3379781_0	289376.THEYE_A0131	2.909e-193	627.0	COG0209@1|root,COG0209@2|Bacteria,3J0MG@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
CMS3_k127_3379781_17	1155718.KB891927_gene2712	1.708e-09	66.0	COG1670@1|root,COG1670@2|Bacteria,2GMDB@201174|Actinobacteria	201174|Actinobacteria	J	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
CMS3_k127_3379781_12	1396418.BATQ01000091_gene5817	2.126e-55	211.0	COG0500@1|root,COG2226@2|Bacteria,46TDK@74201|Verrucomicrobia,2IUIX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_3379781_14	1282876.BAOK01000001_gene1844	6.622e-32	128.0	COG0491@1|root,COG0491@2|Bacteria,1N22F@1224|Proteobacteria,2U2V5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_3463009_7	260799.BAS5225	1.428e-40	159.0	COG1994@1|root,COG1994@2|Bacteria,1V6D4@1239|Firmicutes,4H9SF@91061|Bacilli,1ZCSE@1386|Bacillus	91061|Bacilli	S	Peptidase M50	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
CMS3_k127_3463009_18	357808.RoseRS_4494	2.347e-07	63.0	COG0823@1|root,COG0823@2|Bacteria,2GB27@200795|Chloroflexi,377SI@32061|Chloroflexia	32061|Chloroflexia	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3463009_13	357808.RoseRS_4493	1.401e-23	115.0	COG0741@1|root,COG0741@2|Bacteria	357808.RoseRS_4493|-	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3463009_17	926569.ANT_30450	2.014e-13	80.0	28NSZ@1|root,337UE@2|Bacteria,2GA9H@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3463009_6	448385.sce8138	4.275e-42	164.0	COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,42RQJ@68525|delta/epsilon subdivisions,2WNW8@28221|Deltaproteobacteria,2YVCK@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
CMS3_k127_3463009_3	262724.TT_C1083	2.177e-63	248.0	COG0427@1|root,COG0427@2|Bacteria,1WJIT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Acetyl-CoA hydrolase/transferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
CMS3_k127_3463009_5	765420.OSCT_0652	5.644e-44	179.0	COG1283@1|root,COG1283@2|Bacteria,2GABF@200795|Chloroflexi,374Y2@32061|Chloroflexia	32061|Chloroflexia	P	Na+/Pi-cotransporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_Pi_cotrans
CMS3_k127_3463009_14	29540.C481_11535	5.861e-22	107.0	COG3608@1|root,COG3979@1|root,arCOG02890@2157|Archaea,arCOG07581@2157|Archaea,2XV82@28890|Euryarchaeota,23UBA@183963|Halobacteria	183963|Halobacteria	G	Succinylglutamate desuccinylase aspartoacylase	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA,PKD
CMS3_k127_3463009_1	1120950.KB892742_gene3009	2.354e-76	263.0	COG0412@1|root,COG0412@2|Bacteria,2GJMH@201174|Actinobacteria,4DQY9@85009|Propionibacteriales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
CMS3_k127_3463009_0	1229780.BN381_810009	3.785e-92	322.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_3463009_10	426355.Mrad2831_2101	1.544e-27	122.0	COG0596@1|root,COG0596@2|Bacteria,1R4N4@1224|Proteobacteria,2TYMB@28211|Alphaproteobacteria,1JWZR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_3463009_2	439235.Dalk_4445	9.836e-66	241.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,42STW@68525|delta/epsilon subdivisions,2WPBB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS3_k127_3463009_11	1415755.JQLV01000001_gene1689	3.978e-26	118.0	COG2153@1|root,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,1S8SK@1236|Gammaproteobacteria,1XMBN@135619|Oceanospirillales	135619|Oceanospirillales	S	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
CMS3_k127_3463009_15	205918.Psyr_0086	7.508e-20	99.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1Z4K9@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_9
CMS3_k127_3463009_9	6669.EFX80676	1.464e-33	142.0	COG0491@1|root,KOG0813@2759|Eukaryota,38BZ4@33154|Opisthokonta,3BES6@33208|Metazoa,3CSY3@33213|Bilateria,41XP5@6656|Arthropoda	33208|Metazoa	S	Metallo-beta-lactamase superfamily	LACTB2	GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0031974,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_3463009_8	266779.Meso_0803	2.26e-35	143.0	COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2U67Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
CMS3_k127_3463009_12	1219045.BV98_002630	8.783e-24	108.0	COG4032@1|root,COG4032@2|Bacteria,1R53S@1224|Proteobacteria,2U2R8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_N
CMS3_k127_3463009_16	1121380.JNIW01000001_gene2858	2.427e-18	89.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2
CMS3_k127_3463009_4	359.CN09_30435	2.792e-54	193.0	COG5649@1|root,COG5649@2|Bacteria,1RGY3@1224|Proteobacteria,2U9AG@28211|Alphaproteobacteria,4BF17@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
CMS3_k127_3480020_10	439235.Dalk_5191	4.834e-73	262.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42NTV@68525|delta/epsilon subdivisions,2WJTP@28221|Deltaproteobacteria,2MIWR@213118|Desulfobacterales	1224|Proteobacteria	C	PFAM CoA-binding domain protein	MA20_15065	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
CMS3_k127_3480020_23	644282.Deba_1009	9.187e-05	53.0	COG1410@1|root,COG1410@2|Bacteria,1RGFK@1224|Proteobacteria,42RMB@68525|delta/epsilon subdivisions,2WNS1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM dihydropteroate synthase, DHPS	-	-	2.1.1.258	ko:K15023	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R02289,R10243	RC00004,RC00113,RC01144,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CMS3_k127_3480020_8	1128421.JAGA01000001_gene2461	1.91e-115	396.0	COG0323@1|root,COG0323@2|Bacteria,2NNP7@2323|unclassified Bacteria	2|Bacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
CMS3_k127_3480020_1	1382306.JNIM01000001_gene679	2.351e-180	596.0	COG0249@1|root,COG0249@2|Bacteria,2G5IU@200795|Chloroflexi	200795|Chloroflexi	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	-	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
CMS3_k127_3480020_5	635013.TherJR_0741	2.32e-128	435.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,260R6@186807|Peptococcaceae	186801|Clostridia	C	NADH dehydrogenase	nuoF	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
CMS3_k127_3480020_21	1042877.GQS_04970	1.515e-19	94.0	COG1905@1|root,arCOG04890@2157|Archaea,2XYS3@28890|Euryarchaeota,243WU@183968|Thermococci	183968|Thermococci	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS3_k127_3480020_6	479434.Sthe_1728	7.621e-122	421.0	COG1232@1|root,COG1232@2|Bacteria,2G5VN@200795|Chloroflexi,27Y1I@189775|Thermomicrobia	189775|Thermomicrobia	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
CMS3_k127_3480020_19	765420.OSCT_2581	2.16e-32	140.0	COG0392@1|root,COG0392@2|Bacteria,2G5KF@200795|Chloroflexi,374YY@32061|Chloroflexia	32061|Chloroflexia	S	PFAM conserved	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS3_k127_3480020_12	1382356.JQMP01000004_gene288	6.689e-69	257.0	COG4745@1|root,COG4745@2|Bacteria,2G6HI@200795|Chloroflexi,27XK8@189775|Thermomicrobia	189775|Thermomicrobia	O	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_3480020_13	324602.Caur_1339	1.026e-59	233.0	COG0457@1|root,COG5427@1|root,COG0457@2|Bacteria,COG5427@2|Bacteria,2G5UJ@200795|Chloroflexi,37551@32061|Chloroflexia	32061|Chloroflexia	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298,PMT_2,TPR_16,TPR_19,TPR_8
CMS3_k127_3480020_9	555088.DealDRAFT_1973	3.192e-85	293.0	COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia,42JK9@68298|Syntrophomonadaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
CMS3_k127_3480020_4	1382306.JNIM01000001_gene1910	6.656e-132	465.0	COG1196@1|root,COG1196@2|Bacteria,2G64A@200795|Chloroflexi	200795|Chloroflexi	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
CMS3_k127_3480020_15	537013.CLOSTMETH_03198	3.121e-51	194.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,3WG7D@541000|Ruminococcaceae	186801|Clostridia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
CMS3_k127_3480020_17	324602.Caur_2015	2.37e-41	168.0	COG0617@1|root,COG0617@2|Bacteria,2G8YQ@200795|Chloroflexi,375MA@32061|Chloroflexia	32061|Chloroflexia	H	Polynucleotide adenylyltransferase region	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd
CMS3_k127_3480020_2	324602.Caur_1621	3.816e-179	598.0	COG0847@1|root,COG1199@1|root,COG0847@2|Bacteria,COG1199@2|Bacteria,2G5P4@200795|Chloroflexi,374UA@32061|Chloroflexia	32061|Chloroflexia	L	PFAM Exonuclease, RNase T and DNA polymerase III	-	-	2.7.7.7,3.6.4.12	ko:K02342,ko:K03722	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DEAD_2,Helicase_C_2,RNase_T
CMS3_k127_3480020_20	933262.AXAM01000004_gene2383	4.8e-32	143.0	COG0613@1|root,COG0613@2|Bacteria,1NFVB@1224|Proteobacteria,43BBY@68525|delta/epsilon subdivisions,2X6R1@28221|Deltaproteobacteria,2MPIB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2889)	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	APH,DUF2889,PHP_C
CMS3_k127_3480020_16	311424.DhcVS_348	4.833e-46	187.0	COG1947@1|root,COG1947@2|Bacteria,2G71D@200795|Chloroflexi,34CZT@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
CMS3_k127_3480020_14	926569.ANT_03800	5.009e-58	213.0	COG0030@1|root,COG0030@2|Bacteria,2G6DA@200795|Chloroflexi	200795|Chloroflexi	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
CMS3_k127_3480020_7	1341151.ASZU01000004_gene221	1.417e-121	402.0	COG3007@1|root,COG3007@2|Bacteria,1TWIF@1239|Firmicutes,4HCSV@91061|Bacilli,27BD1@186824|Thermoactinomycetaceae	91061|Bacilli	I	NAD(P)H binding domain of trans-2-enoyl-CoA reductase	fabV	-	1.3.1.44,1.3.1.9	ko:K00209	ko00061,ko00650,ko01100,ko01120,ko01200,ko01212,map00061,map00650,map01100,map01120,map01200,map01212	M00083	R01171,R04429,R04724,R04955,R04958,R04961,R04966,R04969	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Eno-Rase_FAD_bd,Eno-Rase_NADH_b,Enoyl_reductase
CMS3_k127_3480020_18	1122138.AQUZ01000068_gene2416	2.571e-37	151.0	COG0346@1|root,COG0346@2|Bacteria,2GSMD@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_3480020_0	1128421.JAGA01000002_gene639	5.374e-244	768.0	COG0481@1|root,COG0481@2|Bacteria,2NNXG@2323|unclassified Bacteria	2|Bacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
CMS3_k127_3480020_3	324602.Caur_2260	1.466e-146	473.0	COG4608@1|root,COG4608@2|Bacteria,2G5R5@200795|Chloroflexi,3754I@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_3480020_11	246196.MSMEI_0624	5.264e-70	243.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,233DE@1762|Mycobacteriaceae	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
CMS3_k127_3557219_0	697303.Thewi_1196	2.338e-96	332.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,42EUK@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
CMS3_k127_3557219_4	941449.dsx2_0472	3.803e-18	90.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,42UC6@68525|delta/epsilon subdivisions,2WPDD@28221|Deltaproteobacteria,2MBU6@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
CMS3_k127_3557219_3	926550.CLDAP_39240	4.44e-55	209.0	COG1559@1|root,COG1559@2|Bacteria,2G6G8@200795|Chloroflexi	200795|Chloroflexi	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
CMS3_k127_3557219_1	1382356.JQMP01000001_gene1048	6.616e-60	217.0	COG0169@1|root,COG0169@2|Bacteria,2G6FG@200795|Chloroflexi,27XST@189775|Thermomicrobia	189775|Thermomicrobia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
CMS3_k127_3557219_2	929712.KI912613_gene3451	3.785e-55	200.0	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4CPJG@84995|Rubrobacteria	84995|Rubrobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
CMS3_k127_358526_1	479434.Sthe_1106	2.689e-128	441.0	COG0777@1|root,COG0825@1|root,COG0777@2|Bacteria,COG0825@2|Bacteria,2G7S3@200795|Chloroflexi,27XKR@189775|Thermomicrobia	189775|Thermomicrobia	I	catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the	-	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
CMS3_k127_358526_2	13689.BV96_03926	1.187e-76	266.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2TU8W@28211|Alphaproteobacteria,2K0IC@204457|Sphingomonadales	204457|Sphingomonadales	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_358526_4	35754.JNYJ01000043_gene4438	4.333e-54	203.0	COG0671@1|root,COG0671@2|Bacteria,2GMYU@201174|Actinobacteria,4DIVE@85008|Micromonosporales	201174|Actinobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
CMS3_k127_358526_6	406552.NJ7G_3991	5.396e-08	57.0	arCOG06308@1|root,arCOG06308@2157|Archaea,2XYTI@28890|Euryarchaeota,23WT2@183963|Halobacteria	183963|Halobacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_358526_5	1150864.MILUP08_42579	6.15e-14	75.0	COG1977@1|root,COG1977@2|Bacteria,2I5HS@201174|Actinobacteria,4DE22@85008|Micromonosporales	201174|Actinobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
CMS3_k127_358526_0	383372.Rcas_1863	1.578e-265	835.0	COG2414@1|root,COG2414@2|Bacteria,2G5XP@200795|Chloroflexi,376PZ@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS3_k127_358526_3	667014.Thein_2104	2.503e-58	230.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,2GGVI@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33
CMS3_k127_362884_11	309807.SRU_1268	3.646e-18	86.0	COG0520@1|root,COG0520@2|Bacteria,4NJ4E@976|Bacteroidetes,1FJUJ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_362884_12	908612.HMPREF9720_1895	1.271e-10	67.0	COG0346@1|root,COG0346@2|Bacteria,4NQK9@976|Bacteroidetes,2FS1W@200643|Bacteroidia	976|Bacteroidetes	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_2
CMS3_k127_362884_6	1121033.AUCF01000008_gene5747	7.399e-52	189.0	COG0454@1|root,COG0456@2|Bacteria,1RCYQ@1224|Proteobacteria,2TW76@28211|Alphaproteobacteria,2JT9T@204441|Rhodospirillales	204441|Rhodospirillales	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
CMS3_k127_362884_0	1121377.KB906399_gene1738	3.693e-239	763.0	COG1331@1|root,COG1331@2|Bacteria,1WI7F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
CMS3_k127_362884_7	227086.JGI_V11_86592	3.33e-51	199.0	COG0477@1|root,2T0TA@2759|Eukaryota	2759|Eukaryota	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_362884_8	926550.CLDAP_25640	6.463e-29	131.0	COG1524@1|root,COG1524@2|Bacteria,2G5RJ@200795|Chloroflexi	200795|Chloroflexi	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
CMS3_k127_362884_5	398525.KB900701_gene7744	1.825e-61	224.0	COG1024@1|root,COG1024@2|Bacteria,1PK10@1224|Proteobacteria,2TS4M@28211|Alphaproteobacteria,3K2VY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_362884_2	2002.JOEQ01000001_gene4895	2.004e-166	527.0	COG0174@1|root,COG0174@2|Bacteria,2GKU9@201174|Actinobacteria,4EHB0@85012|Streptosporangiales	201174|Actinobacteria	E	Glutamine synthetase, beta-Grasp domain	glnII	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
CMS3_k127_362884_10	1123320.KB889669_gene3270	1.782e-19	89.0	COG1141@1|root,COG1141@2|Bacteria	2|Bacteria	C	electron transfer activity	fdxD	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13,Fer4_15
CMS3_k127_362884_3	2074.JNYD01000006_gene1843	4.292e-127	419.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4E0QR@85010|Pseudonocardiales	201174|Actinobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Reductase_C
CMS3_k127_362884_9	1207063.P24_09626	5.594e-26	117.0	COG3346@1|root,COG3346@2|Bacteria,1MWWG@1224|Proteobacteria,2U0N5@28211|Alphaproteobacteria,2JSD9@204441|Rhodospirillales	204441|Rhodospirillales	S	SURF1-like protein	-	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
CMS3_k127_362884_1	1211815.CBYP010000016_gene2625	1.478e-198	649.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4ES10@85013|Frankiales	201174|Actinobacteria	E	PFAM Peptidase M1, membrane alanine aminopeptidase	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
CMS3_k127_362884_4	1100720.ALKN01000052_gene507	8.024e-110	370.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria	1224|Proteobacteria	G	Major facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_3713291_2	1127134.NOCYR_3185	2.007e-07	58.0	COG0030@1|root,COG0030@2|Bacteria,2H1TK@201174|Actinobacteria,4FUTS@85025|Nocardiaceae	201174|Actinobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family	-	-	2.1.1.184	ko:K00561	-	-	R10716	RC00003,RC03257	br01600,ko00000,ko01000,ko01504,ko03009	-	-	-	RrnaAD
CMS3_k127_3713291_0	358681.BBR47_31640	1.816e-86	298.0	COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,4HC3U@91061|Bacilli,26QCX@186822|Paenibacillaceae	91061|Bacilli	E	selenium transferase	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	SelA
CMS3_k127_3713291_1	1463854.JOHT01000009_gene1903	3.908e-51	190.0	COG3964@1|root,COG3964@2|Bacteria,2IERE@201174|Actinobacteria	201174|Actinobacteria	S	Amidohydrolase family	dho	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
CMS3_k127_372221_4	1172188.KB911820_gene2205	5.295e-08	57.0	COG0622@1|root,COG0622@2|Bacteria,2IFVB@201174|Actinobacteria,4FGEM@85021|Intrasporangiaceae	201174|Actinobacteria	S	Calcineurin-like phosphoesterase superfamily domain	ysnB	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
CMS3_k127_372221_2	1205680.CAKO01000007_gene4412	1.389e-70	254.0	COG2141@1|root,COG2141@2|Bacteria,1NX0H@1224|Proteobacteria,2U42F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_372221_1	479434.Sthe_1230	4.61e-148	477.0	COG2072@1|root,COG2072@2|Bacteria	2|Bacteria	P	N,N-dimethylaniline monooxygenase activity	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
CMS3_k127_372221_0	164757.Mjls_0414	7.387e-149	491.0	COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria,233VG@1762|Mycobacteriaceae	201174|Actinobacteria	K	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE
CMS3_k127_372221_3	1122603.ATVI01000006_gene324	2.999e-10	63.0	COG2141@1|root,COG2141@2|Bacteria,1NX0H@1224|Proteobacteria,1SZ37@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Luciferase-like monooxygenase	luxB	-	1.14.14.3	ko:K15854	ko02020,ko02024,map02020,map02024	-	R10551	RC00080	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
CMS3_k127_372662_10	1121934.AUDX01000022_gene2990	5.061e-08	55.0	COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria,4FNNI@85023|Microbacteriaceae	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	hrrA2	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_372662_9	1172179.AUKV01000027_gene7569	7.241e-12	75.0	COG2310@1|root,COG2340@1|root,COG2310@2|Bacteria,COG2340@2|Bacteria,2GNN0@201174|Actinobacteria	201174|Actinobacteria	T	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP,TerD
CMS3_k127_372662_11	37659.JNLN01000001_gene1563	1.927e-06	60.0	COG2304@1|root,COG2304@2|Bacteria,1V1ZB@1239|Firmicutes,24T2R@186801|Clostridia,36VFZ@31979|Clostridiaceae	186801|Clostridia	M	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
CMS3_k127_372662_12	926566.Terro_1954	9.917e-06	57.0	COG3291@1|root,COG3386@1|root,COG4409@1|root,COG3291@2|Bacteria,COG3386@2|Bacteria,COG4409@2|Bacteria,3Y2U5@57723|Acidobacteria,2JIVC@204432|Acidobacteriia	204432|Acidobacteriia	G	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	ASH,SBBP
CMS3_k127_372662_3	1173026.Glo7428_2690	1.131e-82	285.0	COG1028@1|root,COG1028@2|Bacteria,1G67A@1117|Cyanobacteria	1117|Cyanobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_372662_2	382464.ABSI01000013_gene1799	1.112e-91	319.0	COG2239@1|root,COG2239@2|Bacteria,46S6D@74201|Verrucomicrobia,2IU82@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Divalent cation transporter	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE,MgtE_N
CMS3_k127_372662_8	945713.IALB_2435	4.748e-12	73.0	COG3809@1|root,COG3809@2|Bacteria	2|Bacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-TFIIB
CMS3_k127_372662_7	390235.PputW619_2292	2.528e-26	119.0	COG2267@1|root,COG2267@2|Bacteria,1PFKT@1224|Proteobacteria,1TKK5@1236|Gammaproteobacteria,1YWZ3@136845|Pseudomonas putida group	1236|Gammaproteobacteria	I	PFAM Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_372662_6	1280949.HAD_16682	5.42e-37	146.0	COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,2UCHI@28211|Alphaproteobacteria,43YGP@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Flavin_Reduct,Hydrolase_4
CMS3_k127_372662_5	469381.Dpep_0384	3.307e-50	201.0	COG0388@1|root,COG0388@2|Bacteria,3TC5X@508458|Synergistetes	508458|Synergistetes	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
CMS3_k127_372662_4	479434.Sthe_3203	1.501e-64	230.0	COG0179@1|root,COG0179@2|Bacteria,2G6H8@200795|Chloroflexi,27YS7@189775|Thermomicrobia	189775|Thermomicrobia	Q	Domain of unknown function (DUF2437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
CMS3_k127_372662_1	309801.trd_1909	8.296e-101	352.0	COG0215@1|root,COG0215@2|Bacteria,2G5Z0@200795|Chloroflexi,27XXR@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.3.1.13	ko:K15526	-	-	-	-	ko00000,ko01000	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
CMS3_k127_372662_0	485913.Krac_11674	1.09e-115	382.0	COG2141@1|root,COG2141@2|Bacteria,2G878@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_37329_0	266117.Rxyl_1141	3.107e-31	128.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K09818	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
CMS3_k127_37329_1	1382306.JNIM01000001_gene846	6.911e-17	84.0	COG3224@1|root,COG3224@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09932	-	-	-	-	ko00000	-	-	-	ABM
CMS3_k127_37329_2	1432050.IE4771_CH03083	7.908e-13	73.0	COG5460@1|root,COG5460@2|Bacteria,1N7MS@1224|Proteobacteria,2UIV6@28211|Alphaproteobacteria,4BG11@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterized conserved protein (DUF2164)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2164
CMS3_k127_37329_3	479434.Sthe_0536	1.268e-09	64.0	COG2318@1|root,COG2318@2|Bacteria,2G7AU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM DinB family protein	-	-	-	-	-	-	-	-	-	-	-	-	DinB
CMS3_k127_378400_4	1089453.GOSPT_111_00080	1.064e-07	58.0	COG2114@1|root,COG2114@2|Bacteria,2I900@201174|Actinobacteria,4GBPR@85026|Gordoniaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1647	Guanylate_cyc
CMS3_k127_378400_3	1313172.YM304_21910	3.201e-36	147.0	COG1296@1|root,COG1296@2|Bacteria	2|Bacteria	E	L-valine transmembrane transporter activity	azlC	-	-	-	-	-	-	-	-	-	-	-	AzlC
CMS3_k127_378400_0	1380386.JIAW01000027_gene7088	4.892e-104	352.0	COG2267@1|root,COG3710@1|root,COG2267@2|Bacteria,COG3710@2|Bacteria,2I419@201174|Actinobacteria,234R8@1762|Mycobacteriaceae	201174|Actinobacteria	IK	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Trans_reg_C
CMS3_k127_378400_2	1380390.JIAT01000009_gene1031	1.432e-57	207.0	COG0500@1|root,COG1765@1|root,COG1765@2|Bacteria,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria,4CQ49@84995|Rubrobacteria	201174|Actinobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
CMS3_k127_378400_1	1121127.JAFA01000010_gene4004	3.009e-62	231.0	COG0654@1|root,COG0654@2|Bacteria,1R7NX@1224|Proteobacteria,2WIBD@28216|Betaproteobacteria,1KB40@119060|Burkholderiaceae	28216|Betaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
CMS3_k127_3829746_5	1128421.JAGA01000002_gene55	2.553e-33	137.0	COG2227@1|root,COG2227@2|Bacteria,2NRDG@2323|unclassified Bacteria	2|Bacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_3829746_2	1382306.JNIM01000001_gene1045	8.533e-60	217.0	COG2197@1|root,COG2197@2|Bacteria,2G6PA@200795|Chloroflexi	200795|Chloroflexi	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_3829746_6	381666.H16_B0230	8.652e-16	85.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,2VSDT@28216|Betaproteobacteria,1KH7T@119060|Burkholderiaceae	28216|Betaproteobacteria	T	response regulator	cheY2	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
CMS3_k127_3829746_4	479434.Sthe_0569	1.631e-56	208.0	COG1191@1|root,COG1191@2|Bacteria,2G8JZ@200795|Chloroflexi,27Y01@189775|Thermomicrobia	189775|Thermomicrobia	K	Sigma-70 region 3	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS3_k127_3829746_7	580327.Tthe_2191	2.806e-06	58.0	COG1551@1|root,COG1551@2|Bacteria,1VEEF@1239|Firmicutes,24QPD@186801|Clostridia,42HB6@68295|Thermoanaerobacterales	186801|Clostridia	T	Carbon storage regulator	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
CMS3_k127_3829746_1	926550.CLDAP_27640	6.248e-75	261.0	COG0745@1|root,COG0745@2|Bacteria,2G8CC@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_3829746_3	292459.STH3289	3.131e-57	217.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,sCache_like
CMS3_k127_3829746_8	1907.SGLAU_13480	0.0003543	52.0	COG0793@1|root,COG0793@2|Bacteria,2GKRP@201174|Actinobacteria	201174|Actinobacteria	M	Peptidase, S41	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
CMS3_k127_3829746_0	243164.DET0825	6.553e-129	424.0	COG0119@1|root,COG0119@2|Bacteria,2G5KT@200795|Chloroflexi,34D2K@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
CMS3_k127_3839007_4	319003.Bra1253DRAFT_00172	9.019e-29	117.0	2DRQB@1|root,33CKR@2|Bacteria,1MZI3@1224|Proteobacteria,2UDVN@28211|Alphaproteobacteria,3K512@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3839007_2	1183438.GKIL_4041	1.847e-48	188.0	COG0702@1|root,COG0702@2|Bacteria,1G3KV@1117|Cyanobacteria	1117|Cyanobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
CMS3_k127_3839007_1	1449355.JQNR01000005_gene5623	1.901e-49	193.0	COG4552@1|root,COG4552@2|Bacteria,2GNXZ@201174|Actinobacteria	201174|Actinobacteria	S	N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
CMS3_k127_3839007_0	1394178.AWOO02000002_gene1608	2.459e-124	429.0	COG1804@1|root,COG1804@2|Bacteria,2GMGE@201174|Actinobacteria,4EPCX@85012|Streptosporangiales	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_3839007_3	502025.Hoch_4836	7.817e-42	158.0	COG2223@1|root,COG2223@2|Bacteria,1QVKP@1224|Proteobacteria	1224|Proteobacteria	P	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_3847118_6	44454.NF84_05970	6.422e-35	145.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,234BA@1762|Mycobacteriaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_3847118_9	866895.HBHAL_4450	1.529e-05	57.0	COG0860@1|root,COG3103@1|root,COG0860@2|Bacteria,COG3103@2|Bacteria,COG4991@2|Bacteria,1TR6H@1239|Firmicutes,4H9U6@91061|Bacilli,3NFSY@45667|Halobacillus	91061|Bacilli	M	Ami_3	lytC_1	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3,SLH
CMS3_k127_3847118_8	411462.DORLON_02725	3.572e-07	61.0	COG1102@1|root,COG1102@2|Bacteria,1TRCW@1239|Firmicutes,249Z9@186801|Clostridia,27UR9@189330|Dorea	186801|Clostridia	F	COG NOG14451 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
CMS3_k127_3847118_4	909663.KI867150_gene2380	4.399e-76	269.0	COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,42U8Z@68525|delta/epsilon subdivisions,2WQQT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
CMS3_k127_3847118_5	479434.Sthe_3281	4.206e-67	238.0	COG0726@1|root,COG0726@2|Bacteria,2GB8A@200795|Chloroflexi,27XZW@189775|Thermomicrobia	189775|Thermomicrobia	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
CMS3_k127_3847118_3	448385.sce5872	1.52e-82	282.0	COG0500@1|root,COG0500@2|Bacteria,1QVF3@1224|Proteobacteria	1224|Proteobacteria	Q	Methyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
CMS3_k127_3847118_7	1242864.D187_004967	2.756e-17	96.0	COG1388@1|root,COG3179@1|root,COG1388@2|Bacteria,COG3179@2|Bacteria,1MYUR@1224|Proteobacteria,42UGP@68525|delta/epsilon subdivisions,2WWB8@28221|Deltaproteobacteria,2YZ5E@29|Myxococcales	28221|Deltaproteobacteria	M	Chitinase class I	-	-	-	ko:K03791	-	-	-	-	ko00000	-	GH19	-	Glyco_hydro_19,LysM,PG_binding_1
CMS3_k127_3847118_1	926550.CLDAP_00380	1.949e-147	478.0	COG0427@1|root,COG0427@2|Bacteria,2G60V@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Acetyl-CoA hydrolase transferase	-	-	3.1.2.1	ko:K01067	ko00620,map00620	-	R00227	RC00004,RC00012	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
CMS3_k127_3847118_0	472759.Nhal_2902	1.535e-170	549.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
CMS3_k127_3847118_2	323261.Noc_1255	8.746e-95	318.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales	135613|Chromatiales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CMS3_k127_3851320_0	935840.JAEQ01000025_gene4225	0.0	1363.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS2I@28211|Alphaproteobacteria,43HJU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
CMS3_k127_3851320_1	1123368.AUIS01000002_gene1535	8.058e-120	401.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,2NCHN@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Aminopeptidase P, N-terminal domain	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
CMS3_k127_3851320_3	596152.DesU5LDRAFT_0469	8.402e-29	126.0	COG0730@1|root,COG0730@2|Bacteria,1Q59Y@1224|Proteobacteria,430VR@68525|delta/epsilon subdivisions,2WVKN@28221|Deltaproteobacteria,2M8GD@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS3_k127_3851320_2	1122247.C731_4804	4.471e-76	272.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,234BA@1762|Mycobacteriaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_3851320_4	1218074.BAXZ01000016_gene3330	2.378e-07	55.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,1K0E9@119060|Burkholderiaceae	28216|Betaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_3853818_1	1232410.KI421425_gene1553	1.039e-121	443.0	COG4932@1|root,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
CMS3_k127_3853818_0	1232410.KI421425_gene1552	0.0	1893.0	COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
CMS3_k127_3862636_1	1380394.JADL01000016_gene446	1.878e-23	106.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2TTP3@28211|Alphaproteobacteria,2JRU7@204441|Rhodospirillales	204441|Rhodospirillales	J	ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
CMS3_k127_3862636_0	1207063.P24_17680	6.799e-211	664.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,2JQP5@204441|Rhodospirillales	204441|Rhodospirillales	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
CMS3_k127_3871897_3	292459.STH906	0.0009347	51.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1TR2N@1239|Firmicutes,249FQ@186801|Clostridia	186801|Clostridia	E	Peptidase, S9A B C family, catalytic domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
CMS3_k127_3871897_1	42256.RradSPS_3091	1.087e-86	297.0	COG0530@1|root,COG0530@2|Bacteria,2GJR3@201174|Actinobacteria	201174|Actinobacteria	P	PFAM sodium calcium exchanger	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS3_k127_3871897_2	1382356.JQMP01000003_gene1615	6.561e-07	56.0	2ESS5@1|root,33KAI@2|Bacteria,2G7C4@200795|Chloroflexi,27YHT@189775|Thermomicrobia	189775|Thermomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3871897_0	525904.Tter_1033	8.975e-98	329.0	COG0482@1|root,COG0482@2|Bacteria,2NNPW@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
CMS3_k127_3882821_8	479434.Sthe_1013	9.244e-05	50.0	COG3870@1|root,COG3870@2|Bacteria	2|Bacteria	S	Cyclic-di-AMP receptor	-	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
CMS3_k127_3882821_6	861299.J421_1645	5.567e-35	140.0	2A4CF@1|root,30SY3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
CMS3_k127_3882821_1	102129.Lepto7375DRAFT_1220	1.491e-128	424.0	COG1960@1|root,COG1960@2|Bacteria,1G4UB@1117|Cyanobacteria	1117|Cyanobacteria	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_3882821_0	502025.Hoch_4973	6.036e-187	595.0	COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria,42NWP@68525|delta/epsilon subdivisions,2WJUA@28221|Deltaproteobacteria,2YUE6@29|Myxococcales	28221|Deltaproteobacteria	L	Deoxyribodipyrimidine photo-lyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
CMS3_k127_3882821_3	926569.ANT_25430	7.871e-72	255.0	COG2335@1|root,COG2335@2|Bacteria,2G7AJ@200795|Chloroflexi	200795|Chloroflexi	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
CMS3_k127_3882821_5	1123251.ATWM01000001_gene592	1.128e-37	153.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,2HXHD@201174|Actinobacteria,4FGVZ@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
CMS3_k127_3882821_4	983917.RGE_01560	1.325e-40	167.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,2VHZ1@28216|Betaproteobacteria,1KJ7K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Alpha beta hydrolase	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
CMS3_k127_3882821_2	1268622.AVS7_02054	1.863e-74	263.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2VPM0@28216|Betaproteobacteria,4ACTH@80864|Comamonadaceae	28216|Betaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS3_k127_3882821_7	326427.Cagg_0664	3.295e-12	78.0	COG3118@1|root,COG3118@2|Bacteria,2G90Y@200795|Chloroflexi,376KV@32061|Chloroflexia	32061|Chloroflexia	O	PFAM Thioredoxin domain	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
CMS3_k127_3896000_0	497964.CfE428DRAFT_5140	0.0	1501.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,46SCB@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Conserved region in glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
CMS3_k127_3896000_1	751945.Theos_2129	1.145e-11	68.0	COG0697@1|root,COG0697@2|Bacteria,1WJ6P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_3901580_0	1408473.JHXO01000008_gene2710	8.777e-94	326.0	COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,2FN74@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF4968,Gal_mutarotas_2,Glyco_hydro_31
CMS3_k127_3901896_9	561175.KB894094_gene1489	3.39e-24	113.0	COG0671@1|root,COG0671@2|Bacteria,2GMYU@201174|Actinobacteria,4EKKP@85012|Streptosporangiales	201174|Actinobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	GT87,PAP2_3
CMS3_k127_3901896_2	402881.Plav_0474	3.991e-77	268.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,1JNH3@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_3901896_3	298655.KI912267_gene7788	5.822e-70	247.0	COG1028@1|root,COG1028@2|Bacteria	298655.KI912267_gene7788|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3901896_0	1382356.JQMP01000001_gene1198	2.484e-136	463.0	COG0028@1|root,COG0028@2|Bacteria,2GA3W@200795|Chloroflexi,27Z3I@189775|Thermomicrobia	189775|Thermomicrobia	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_3901896_1	1173028.ANKO01000153_gene5369	6.872e-83	293.0	COG3386@1|root,COG3386@2|Bacteria,1G05C@1117|Cyanobacteria,1H9TR@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM SMP-30 Gluconolaconase LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
CMS3_k127_3901896_4	1120948.KB903229_gene5150	5.726e-68	243.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria,4E0A8@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	ko:K18471	ko00640,map00640	-	R10718	RC00739	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
CMS3_k127_3901896_6	1218084.BBJK01000089_gene5877	6.412e-47	182.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2VMPR@28216|Betaproteobacteria,1K4UZ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	idnD	-	1.1.1.264	ko:K00098	-	-	R05684	RC00089	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_3901896_8	439235.Dalk_4877	1.714e-28	123.0	COG0613@1|root,COG0613@2|Bacteria,1NFVB@1224|Proteobacteria,43BBY@68525|delta/epsilon subdivisions,2X6R1@28221|Deltaproteobacteria,2MPIB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2889)	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	APH,DUF2889,PHP_C
CMS3_k127_3901896_7	867903.ThesuDRAFT_02085	1.562e-46	182.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,3WCFX@538999|Clostridiales incertae sedis	186801|Clostridia	C	PFAM Electron transfer flavoprotein domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
CMS3_k127_3901896_5	1348657.M622_02910	7.71e-50	185.0	COG2086@1|root,COG2086@2|Bacteria	2|Bacteria	C	electron transfer activity	ygcR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
CMS3_k127_3902760_33	1499685.CCFJ01000053_gene2849	2.746e-10	70.0	2EAZJ@1|root,3350E@2|Bacteria,1VGFD@1239|Firmicutes,4HNX8@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3153
CMS3_k127_3902760_26	1504319.GM45_3185	1.063e-23	108.0	COG1146@1|root,COG1146@2|Bacteria,2IKVN@201174|Actinobacteria,3UWRV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	4Fe-4S binding domain	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	Fer4
CMS3_k127_3902760_1	635013.TherJR_2731	2.779e-179	583.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,260I5@186807|Peptococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
CMS3_k127_3902760_16	316058.RPB_0447	8.217e-53	197.0	COG2518@1|root,COG2518@2|Bacteria,1QURA@1224|Proteobacteria,2TW4I@28211|Alphaproteobacteria,3K6TI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CMS3_k127_3902760_10	311424.DhcVS_998	2.117e-87	299.0	COG4974@1|root,COG4974@2|Bacteria,2G6CI@200795|Chloroflexi,34D04@301297|Dehalococcoidia	301297|Dehalococcoidia	D	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS3_k127_3902760_2	319795.Dgeo_0004	4.436e-168	539.0	COG0148@1|root,COG0148@2|Bacteria,1WIST@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
CMS3_k127_3902760_7	1304880.JAGB01000002_gene2026	2.139e-120	403.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia	186801|Clostridia	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
CMS3_k127_3902760_17	1037409.BJ6T_73470	8.536e-47	179.0	COG1011@1|root,COG1011@2|Bacteria,1PUN6@1224|Proteobacteria,2TY0G@28211|Alphaproteobacteria,3JU2Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CMS3_k127_3902760_6	986075.CathTA2_1874	1.236e-129	430.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,4H9T4@91061|Bacilli	91061|Bacilli	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
CMS3_k127_3902760_25	926569.ANT_16040	1.949e-24	108.0	COG0228@1|root,COG0228@2|Bacteria,2G7A3@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
CMS3_k127_3902760_30	243164.DET0567	1.202e-13	77.0	COG1837@1|root,COG1837@2|Bacteria,2G7DU@200795|Chloroflexi,34DG8@301297|Dehalococcoidia	301297|Dehalococcoidia	S	KH domain	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
CMS3_k127_3902760_22	926550.CLDAP_37810	1.61e-27	121.0	COG0806@1|root,COG0806@2|Bacteria,2G707@200795|Chloroflexi	200795|Chloroflexi	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
CMS3_k127_3902760_28	196162.Noca_2546	2.176e-21	111.0	COG0584@1|root,COG0584@2|Bacteria,2GVYH@201174|Actinobacteria	201174|Actinobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3902760_18	56110.Oscil6304_5626	3.3e-46	172.0	COG4067@1|root,COG4067@2|Bacteria,1G6KI@1117|Cyanobacteria,1HBYC@1150|Oscillatoriales	1117|Cyanobacteria	O	Putative ATP-dependant zinc protease	-	-	-	-	-	-	-	-	-	-	-	-	Zn_protease
CMS3_k127_3902760_4	82654.Pse7367_2748	5.76e-140	457.0	COG0189@1|root,COG0189@2|Bacteria,1G0DT@1117|Cyanobacteria,1H6ZT@1150|Oscillatoriales	1117|Cyanobacteria	F	Belongs to the RimK family	rimK	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK,Zn_protease
CMS3_k127_3902760_31	1487921.DP68_09770	2.366e-12	74.0	COG4758@1|root,COG4758@2|Bacteria,1VE20@1239|Firmicutes,24J2R@186801|Clostridia,36JE0@31979|Clostridiaceae	186801|Clostridia	S	Cell wall-active antibiotics response 4TMS YvqF	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
CMS3_k127_3902760_12	110319.CF8_1768	2.234e-78	277.0	COG2124@1|root,COG2124@2|Bacteria,2GJ3T@201174|Actinobacteria,4DWK2@85009|Propionibacteriales	201174|Actinobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
CMS3_k127_3902760_0	105422.BBPM01000001_gene4828	9.842e-187	604.0	COG0339@1|root,COG0339@2|Bacteria,2GM2Z@201174|Actinobacteria,2NF2Z@228398|Streptacidiphilus	201174|Actinobacteria	E	Peptidase family M3	-	-	3.4.24.15	ko:K01392	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
CMS3_k127_3902760_29	68223.JNZY01000002_gene4926	3.941e-14	74.0	COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
CMS3_k127_3902760_8	1033743.CAES01000098_gene2690	7.118e-104	355.0	COG2124@1|root,COG2124@2|Bacteria,1TPWZ@1239|Firmicutes,4HAGS@91061|Bacilli,26V2H@186822|Paenibacillaceae	91061|Bacilli	Q	cytochrome P450	bioI	GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.14.14.46	ko:K16593	ko00780,ko01100,map00780,map01100	M00573	R10123	-	ko00000,ko00001,ko00002,ko00199,ko01000	-	-	-	p450
CMS3_k127_3902760_14	1077974.GOEFS_044_00250	1.051e-74	263.0	COG2141@1|root,COG2141@2|Bacteria,2H62W@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_3902760_11	1415166.NONO_c36050	3.149e-84	287.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4FX4V@85025|Nocardiaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1,SnoaL_2
CMS3_k127_3902760_20	113395.AXAI01000002_gene5239	4.979e-37	158.0	COG0778@1|root,COG0778@2|Bacteria,1NCBD@1224|Proteobacteria	1224|Proteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS3_k127_3902760_3	525904.Tter_1201	1.066e-165	549.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	MdlB	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_3902760_5	867845.KI911784_gene1197	1.631e-135	453.0	COG1132@1|root,COG1132@2|Bacteria,2G5QH@200795|Chloroflexi,376DV@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_3902760_19	1313172.YM304_20690	4.393e-41	157.0	COG2606@1|root,COG2606@2|Bacteria,2GKUX@201174|Actinobacteria	201174|Actinobacteria	S	YbaK prolyl-tRNA synthetase associated region	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
CMS3_k127_3902760_9	1333998.M2A_1717	1.844e-100	340.0	COG2141@1|root,COG2141@2|Bacteria,1MVF0@1224|Proteobacteria,2TTR7@28211|Alphaproteobacteria,4BRF4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_3902760_23	1173025.GEI7407_0031	8.339e-27	119.0	COG1853@1|root,COG1853@2|Bacteria,1G2RV@1117|Cyanobacteria,1H7U3@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
CMS3_k127_3902760_21	1207063.P24_08574	4.349e-29	128.0	COG4319@1|root,COG4319@2|Bacteria,1MZK9@1224|Proteobacteria,2U5AR@28211|Alphaproteobacteria,2JTW8@204441|Rhodospirillales	204441|Rhodospirillales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
CMS3_k127_3902760_13	1121946.AUAX01000027_gene7984	2.438e-76	275.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4DB58@85008|Micromonosporales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_3902760_34	208444.JNYY01000014_gene4185	8.51e-07	59.0	COG3871@1|root,COG3871@2|Bacteria,2IFC3@201174|Actinobacteria,4E74M@85010|Pseudonocardiales	201174|Actinobacteria	S	stress protein (general stress protein 26)	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_3902760_27	1122247.C731_0851	1.198e-21	100.0	COG3871@1|root,COG3871@2|Bacteria,2IFC3@201174|Actinobacteria,238T2@1762|Mycobacteriaceae	201174|Actinobacteria	S	stress protein (general stress protein 26)	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_3902760_15	452637.Oter_3529	7.481e-56	203.0	COG0546@1|root,COG0546@2|Bacteria,46YH3@74201|Verrucomicrobia,3K9K2@414999|Opitutae	414999|Opitutae	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS3_k127_3902760_32	937777.Deipe_2486	9.221e-11	72.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	APH,Abhydrolase_6,Hydrolase_4,Peptidase_S9
CMS3_k127_3902760_24	1382356.JQMP01000003_gene1929	1.79e-25	106.0	COG0154@1|root,COG0154@2|Bacteria,2G7WJ@200795|Chloroflexi,27XWA@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS3_k127_3927619_3	1089548.KI783301_gene2787	2.265e-07	54.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,4HAGN@91061|Bacilli,3WG2H@539002|Bacillales incertae sedis	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_3927619_2	861299.J421_2040	8.947e-58	210.0	COG0639@1|root,COG0639@2|Bacteria,1ZUFY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
CMS3_k127_3927619_0	518766.Rmar_1739	7.112e-156	503.0	COG0673@1|root,COG0673@2|Bacteria,4NJ92@976|Bacteroidetes	976|Bacteroidetes	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_3927619_1	1242864.D187_007980	7.766e-60	228.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,438PG@68525|delta/epsilon subdivisions,2X3X6@28221|Deltaproteobacteria,2YXF3@29|Myxococcales	28221|Deltaproteobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
CMS3_k127_3973112_17	926569.ANT_06980	9.714e-52	192.0	COG0673@1|root,COG0673@2|Bacteria,2G6KB@200795|Chloroflexi	200795|Chloroflexi	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_3973112_11	767817.Desgi_3217	1.916e-69	249.0	COG4221@1|root,COG4221@2|Bacteria,1UIB4@1239|Firmicutes,25EG6@186801|Clostridia,265GT@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_3973112_19	909613.UO65_3318	7.446e-36	143.0	COG0645@1|root,COG0645@2|Bacteria,2I4N7@201174|Actinobacteria	201174|Actinobacteria	S	Chloramphenicol phosphotransferase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
CMS3_k127_3973112_0	1160137.KB907308_gene7463	6.562e-133	446.0	28JZQ@1|root,2Z9PN@2|Bacteria,2I9HT@201174|Actinobacteria,4G6HD@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3973112_4	953739.SVEN_0524	1.001e-98	335.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	lipP	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_3973112_26	1131730.BAVI_19319	1.173e-24	111.0	2DNQ8@1|root,32YJ3@2|Bacteria,1VHCH@1239|Firmicutes,4HQ4Q@91061|Bacilli,1ZJ8K@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3973112_7	1122614.JHZF01000014_gene2718	1.527e-89	307.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria	1224|Proteobacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_3973112_25	1229203.KI301992_gene138	8.961e-26	113.0	COG1595@1|root,COG1595@2|Bacteria,2HG2Z@201174|Actinobacteria,3UXS2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
CMS3_k127_3973112_30	479435.Kfla_3996	1.639e-14	78.0	COG0346@1|root,COG0346@2|Bacteria,2INT0@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3973112_29	1449048.JQKU01000009_gene769	2.057e-16	93.0	COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria,23AQX@1762|Mycobacteriaceae	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
CMS3_k127_3973112_21	479434.Sthe_2283	2.878e-33	144.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3973112_27	118163.Ple7327_4428	7.26e-24	110.0	2BG65@1|root,32A2Y@2|Bacteria,1G6VZ@1117|Cyanobacteria,3VJZ3@52604|Pleurocapsales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3973112_28	1385518.N798_05890	9.758e-21	105.0	COG1295@1|root,COG1295@2|Bacteria,2GM6P@201174|Actinobacteria,4FF5I@85021|Intrasporangiaceae	201174|Actinobacteria	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
CMS3_k127_3973112_33	1382356.JQMP01000004_gene178	0.000197	53.0	COG4961@1|root,COG4961@2|Bacteria,2GB9G@200795|Chloroflexi,27YAR@189775|Thermomicrobia	189775|Thermomicrobia	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
CMS3_k127_3973112_5	552811.Dehly_1197	1.686e-96	340.0	COG4826@1|root,COG4826@2|Bacteria,2GBWN@200795|Chloroflexi,34D50@301297|Dehalococcoidia	301297|Dehalococcoidia	M	SERine  Proteinase INhibitors	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
CMS3_k127_3973112_1	485913.Krac_4715	5.875e-117	394.0	COG2272@1|root,COG2272@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
CMS3_k127_3973112_23	926554.KI912664_gene1577	1.876e-29	130.0	29XYR@1|root,30JRD@2|Bacteria,1WNBY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Lysyl oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Lysyl_oxidase
CMS3_k127_3973112_14	33898.JRHJ01000079_gene1405	2.544e-52	198.0	COG1609@1|root,COG1609@2|Bacteria,2GNVD@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS3_k127_3973112_22	1120971.AUCA01000059_gene395	9.663e-30	134.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli,278VM@186823|Alicyclobacillaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS3_k127_3973112_9	1033802.SSPSH_002280	2.327e-80	278.0	COG1028@1|root,COG1028@2|Bacteria,1R4GD@1224|Proteobacteria,1S7QG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_3973112_18	405948.SACE_1028	3.539e-50	190.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4DYVB@85010|Pseudonocardiales	201174|Actinobacteria	I	PFAM Enoyl-CoA hydratase isomerase	chcB	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS3_k127_3973112_13	1444309.JAQG01000004_gene3669	1.214e-52	207.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26TIQ@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_3973112_8	381666.H16_A2950	6.572e-88	299.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VR1Q@28216|Betaproteobacteria,1K78Q@119060|Burkholderiaceae	28216|Betaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS3_k127_3973112_10	1122919.KB905595_gene4208	5.638e-78	271.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HDBB@91061|Bacilli,274T8@186822|Paenibacillaceae	91061|Bacilli	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
CMS3_k127_3973112_3	309799.DICTH_1036	2.01e-107	358.0	COG0444@1|root,COG0444@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_3973112_2	867903.ThesuDRAFT_01380	1.825e-112	377.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_3973112_32	797210.Halxa_1277	8.993e-09	68.0	COG1520@1|root,arCOG02482@2157|Archaea,2XTAZ@28890|Euryarchaeota,23TDC@183963|Halobacteria	183963|Halobacteria	S	Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS3_k127_3973112_6	1123504.JQKD01000012_gene1258	7.285e-90	313.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJ3K@28216|Betaproteobacteria,4AG7T@80864|Comamonadaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.15	ko:K07544	ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220	M00418	R05588	RC00014,RC00137	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
CMS3_k127_3973112_12	767817.Desgi_0645	1.546e-67	244.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia,2607C@186807|Peptococcaceae	186801|Clostridia	C	PFAM CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_3973112_24	1117108.PAALTS15_15646	7.008e-26	110.0	2C3PV@1|root,3307H@2|Bacteria,1VJ1P@1239|Firmicutes,4HPE6@91061|Bacilli,26ZE6@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF2834)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2834
CMS3_k127_3973112_20	1537715.JQFJ01000002_gene503	1.519e-33	140.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2TU8W@28211|Alphaproteobacteria,2K0IC@204457|Sphingomonadales	204457|Sphingomonadales	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_3973112_16	1248916.ANFY01000011_gene1083	3.83e-52	187.0	COG0251@1|root,COG0251@2|Bacteria,1RDFC@1224|Proteobacteria,2U8PR@28211|Alphaproteobacteria,2K6NW@204457|Sphingomonadales	204457|Sphingomonadales	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
CMS3_k127_3973112_35	1122925.KB895387_gene2807	0.000601	43.0	2DREZ@1|root,33BFB@2|Bacteria,1UPXP@1239|Firmicutes,4IVCS@91061|Bacilli,2743X@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3995849_8	1347369.CCAD010000056_gene4276	4.576e-47	180.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli,1ZE3C@1386|Bacillus	91061|Bacilli	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS3_k127_3995849_4	1282876.BAOK01000001_gene1241	2.775e-54	203.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2TST5@28211|Alphaproteobacteria,4BRH5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS3_k127_3995849_15	1172186.KB911463_gene3795	3.468e-24	112.0	COG3871@1|root,COG3871@2|Bacteria,2I2QZ@201174|Actinobacteria,234WV@1762|Mycobacteriaceae	201174|Actinobacteria	S	PFAM pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_3995849_17	459495.SPLC1_S102990	7.389e-17	84.0	COG2127@1|root,COG2127@2|Bacteria,1G6M6@1117|Cyanobacteria,1HBNB@1150|Oscillatoriales	1117|Cyanobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
CMS3_k127_3995849_6	1121396.KB892935_gene3861	9.186e-52	203.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,42PZA@68525|delta/epsilon subdivisions,2WJ9A@28221|Deltaproteobacteria,2MKHA@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_3995849_10	4529.ORUFI01G43170.1	6.331e-43	165.0	COG0216@1|root,KOG2726@2759|Eukaryota,37SSY@33090|Viridiplantae,3G9BB@35493|Streptophyta,3KTXR@4447|Liliopsida,3I9YQ@38820|Poales	35493|Streptophyta	J	RF-1 domain	-	-	-	-	-	-	-	-	-	-	-	-	RF-1
CMS3_k127_3995849_1	485913.Krac_0700	1.057e-91	313.0	COG0002@1|root,COG0002@2|Bacteria,2G6D0@200795|Chloroflexi	2|Bacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1782,iSSON_1240.SSON_4131,iYO844.BSU11190	Semialdhyde_dh,Semialdhyde_dhC
CMS3_k127_3995849_18	870187.Thini_2305	1.953e-12	73.0	COG3070@1|root,COG3070@2|Bacteria,1N8X8@1224|Proteobacteria,1RW2B@1236|Gammaproteobacteria,4635U@72273|Thiotrichales	72273|Thiotrichales	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
CMS3_k127_3995849_20	1122138.AQUZ01000014_gene7108	2.043e-08	67.0	COG0477@1|root,COG0477@2|Bacteria,2GKFJ@201174|Actinobacteria,4DQD5@85009|Propionibacteriales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_3995849_14	926569.ANT_25600	4.546e-26	118.0	COG1595@1|root,COG1595@2|Bacteria,2G6X7@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
CMS3_k127_3995849_21	339670.Bamb_1317	2.131e-07	64.0	COG1652@1|root,COG4254@1|root,COG1652@2|Bacteria,COG4254@2|Bacteria,1NKA2@1224|Proteobacteria,2VMS2@28216|Betaproteobacteria,1K26R@119060|Burkholderiaceae	28216|Betaproteobacteria	M	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
CMS3_k127_3995849_5	68219.JNXI01000004_gene2835	1.417e-52	199.0	COG0668@1|root,COG0668@2|Bacteria,2GZI1@201174|Actinobacteria	201174|Actinobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,cNMP_binding
CMS3_k127_3995849_7	593750.Metfor_0576	1.259e-47	181.0	arCOG08211@1|root,arCOG08211@2157|Archaea,2XW85@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3995849_12	2074.JNYD01000011_gene69	2.743e-29	133.0	COG0746@1|root,COG0746@2|Bacteria,2IACX@201174|Actinobacteria	201174|Actinobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS3_k127_3995849_11	926550.CLDAP_01030	6.242e-35	145.0	COG2068@1|root,COG2068@2|Bacteria,2G6W9@200795|Chloroflexi	200795|Chloroflexi	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS3_k127_3995849_9	1382356.JQMP01000003_gene1897	8.324e-45	169.0	COG3358@1|root,COG3358@2|Bacteria,2G9CX@200795|Chloroflexi,27Z2J@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
CMS3_k127_3995849_0	562970.Btus_0515	5.565e-163	532.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HA3S@91061|Bacilli,2781B@186823|Alicyclobacillaceae	91061|Bacilli	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_3995849_19	652103.Rpdx1_3362	9.447e-10	65.0	COG3620@1|root,COG3620@2|Bacteria,1N84U@1224|Proteobacteria,2TWPS@28211|Alphaproteobacteria,3JZE2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
CMS3_k127_3995849_16	1227453.C444_11827	1.739e-19	99.0	COG0596@1|root,arCOG01648@2157|Archaea,2XUNG@28890|Euryarchaeota,23SVU@183963|Halobacteria	183963|Halobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	catD	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
CMS3_k127_3995849_2	1247963.JPHU01000008_gene2802	4.142e-64	236.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2TVZH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Mg2 and Co2 transporter CorB	corB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
CMS3_k127_3995849_3	561175.KB894094_gene1747	1.739e-59	218.0	COG1011@1|root,COG1011@2|Bacteria,2I3IU@201174|Actinobacteria,4EP7A@85012|Streptosporangiales	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CMS3_k127_3995849_13	316055.RPE_2035	5.28e-28	122.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2TR9R@28211|Alphaproteobacteria,3JT1H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Rhodanese Homology Domain	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
CMS3_k127_4002317_0	552811.Dehly_0797	0.0	1069.0	COG0178@1|root,COG0178@2|Bacteria,2G60U@200795|Chloroflexi,34CMB@301297|Dehalococcoidia	301297|Dehalococcoidia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS3_k127_4009133_0	1038859.AXAU01000011_gene2392	1.53e-121	398.0	COG0277@1|root,COG0277@2|Bacteria,1MXTV@1224|Proteobacteria,2U0T4@28211|Alphaproteobacteria,3JRE4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	PFAM FAD linked oxidase domain protein	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
CMS3_k127_4009133_1	298654.FraEuI1c_5775	3.607e-21	95.0	COG2267@1|root,COG2267@2|Bacteria,2I0NW@201174|Actinobacteria,4EX2Y@85013|Frankiales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
CMS3_k127_401400_2	1123248.KB893321_gene567	8.387e-07	59.0	COG3291@1|root,COG3291@2|Bacteria,4P401@976|Bacteroidetes	976|Bacteroidetes	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_401400_1	388399.SSE37_09273	3.978e-20	98.0	COG2818@1|root,COG2818@2|Bacteria,1R3WB@1224|Proteobacteria,2TTR8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	3-methyladenine DNA glycosylase	MA20_23545	-	-	-	-	-	-	-	-	-	-	-	Adenine_glyco
CMS3_k127_401400_0	1394178.AWOO02000020_gene7405	2.991e-24	109.0	COG0491@1|root,COG0491@2|Bacteria,2GKJA@201174|Actinobacteria,4EHHQ@85012|Streptosporangiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_4015237_8	477641.MODMU_1532	3.718e-23	104.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
CMS3_k127_4015237_6	1382306.JNIM01000001_gene1380	8.425e-28	119.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
CMS3_k127_4015237_11	937777.Deipe_3178	4.379e-10	64.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
CMS3_k127_4015237_13	933801.Ahos_0200	6.371e-05	46.0	COG1225@1|root,arCOG00310@2157|Archaea,2XQPI@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
CMS3_k127_4015237_5	357808.RoseRS_2641	3.78e-34	152.0	COG0741@1|root,COG1729@1|root,COG0741@2|Bacteria,COG1729@2|Bacteria,2G6NM@200795|Chloroflexi,374VP@32061|Chloroflexia	32061|Chloroflexia	M	Lytic transglycosylase catalytic	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_16
CMS3_k127_4015237_12	867845.KI911784_gene2749	1.917e-06	61.0	COG0230@1|root,COG0230@2|Bacteria,2G7BX@200795|Chloroflexi,3760E@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
CMS3_k127_4015237_9	1229172.JQFA01000002_gene4057	2.149e-19	98.0	COG0759@1|root,COG0759@2|Bacteria,1G90B@1117|Cyanobacteria,1HCVK@1150|Oscillatoriales	1117|Cyanobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
CMS3_k127_4015237_10	1394178.AWOO02000013_gene7976	8.33e-15	87.0	COG0515@1|root,COG1520@1|root,COG0515@2|Bacteria,COG1520@2|Bacteria,2GIV0@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4328,PQQ_2,PQQ_3,Peripla_BP_6,Pkinase,Pkinase_Tyr,TPR_12,WD40
CMS3_k127_4015237_2	311424.DhcVS_910	2.475e-46	179.0	COG0706@1|root,COG0706@2|Bacteria,2G6N0@200795|Chloroflexi,34D1I@301297|Dehalococcoidia	301297|Dehalococcoidia	U	60Kd inner membrane protein	-	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
CMS3_k127_4015237_7	765420.OSCT_0242	4.578e-24	116.0	COG1847@1|root,COG1847@2|Bacteria,2G6XH@200795|Chloroflexi,375F5@32061|Chloroflexia	32061|Chloroflexia	S	PFAM single-stranded nucleic acid binding R3H domain protein	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
CMS3_k127_4015237_4	248742.XP_005647707.1	3.779e-35	146.0	2ECHE@1|root,2SICA@2759|Eukaryota,37ZF4@33090|Viridiplantae,34JHP@3041|Chlorophyta	3041|Chlorophyta	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CMS3_k127_4015237_0	1051632.TPY_3825	1.002e-80	288.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,3WD3D@538999|Clostridiales incertae sedis	186801|Clostridia	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS3_k127_4015237_1	1382356.JQMP01000003_gene2142	2.947e-76	266.0	COG1475@1|root,COG1475@2|Bacteria,2G6EK@200795|Chloroflexi,27XFW@189775|Thermomicrobia	189775|Thermomicrobia	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
CMS3_k127_4015237_3	290340.AAur_pTC20182	1.781e-41	158.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,1W96K@1268|Micrococcaceae	201174|Actinobacteria	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
CMS3_k127_4044360_15	767817.Desgi_2527	3.546e-40	157.0	COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,248NA@186801|Clostridia,26127@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03525	GHMP_kinases_C,GHMP_kinases_N
CMS3_k127_4044360_2	311424.DhcVS_1515	1.516e-146	476.0	COG0527@1|root,COG0527@2|Bacteria,2G5U9@200795|Chloroflexi,34CW8@301297|Dehalococcoidia	301297|Dehalococcoidia	E	ACT domain	metL	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT
CMS3_k127_4044360_0	552811.Dehly_1577	0.0	1075.0	COG0587@1|root,COG0587@2|Bacteria,2G5IY@200795|Chloroflexi,34CSK@301297|Dehalococcoidia	301297|Dehalococcoidia	L	DNA-directed DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
CMS3_k127_4044360_4	459349.CLOAM1410	1.517e-113	377.0	COG0714@1|root,COG0714@2|Bacteria,2NNMQ@2323|unclassified Bacteria	2|Bacteria	S	ATPase associated with various cellular	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_4044360_8	518766.Rmar_2321	4.787e-74	272.0	COG1721@1|root,COG1721@2|Bacteria,4NE2N@976|Bacteroidetes,1FIVV@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_4044360_24	391625.PPSIR1_31753	8.174e-15	86.0	2DQMB@1|root,337KD@2|Bacteria,1NKJH@1224|Proteobacteria,42X0X@68525|delta/epsilon subdivisions,2WSJT@28221|Deltaproteobacteria,2YVNT@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4044360_11	1089550.ATTH01000001_gene1008	1.456e-62	228.0	COG2304@1|root,COG2304@2|Bacteria,4NDUC@976|Bacteroidetes,1FIMW@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	von Willebrand factor type A domain	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
CMS3_k127_4044360_23	1304885.AUEY01000067_gene1312	5.409e-26	125.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,42M45@68525|delta/epsilon subdivisions,2WM19@28221|Deltaproteobacteria,2MHT6@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM von Willebrand factor type A domain	batB	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,TPR_1,TPR_16,TPR_2,VWA,VWA_2
CMS3_k127_4044360_12	867845.KI911784_gene3482	2.561e-61	238.0	COG1305@1|root,COG1305@2|Bacteria,2G66M@200795|Chloroflexi,37570@32061|Chloroflexia	32061|Chloroflexia	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
CMS3_k127_4044360_7	479434.Sthe_1589	5.171e-84	294.0	COG1721@1|root,COG1721@2|Bacteria,2G5XH@200795|Chloroflexi,27XZ3@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_4044360_3	357808.RoseRS_0692	2.535e-127	419.0	COG0714@1|root,COG0714@2|Bacteria,2G66D@200795|Chloroflexi,374V5@32061|Chloroflexia	32061|Chloroflexia	S	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_4044360_16	926550.CLDAP_14690	3.274e-36	153.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2G901@200795|Chloroflexi	200795|Chloroflexi	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
CMS3_k127_4044360_22	562970.Btus_1248	1.402e-29	136.0	COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,4HH8P@91061|Bacilli,278FE@186823|Alicyclobacillaceae	91061|Bacilli	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
CMS3_k127_4044360_13	1265313.HRUBRA_02571	1.502e-40	162.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Ribosomal protein L11 methyltransferase	prmA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006480,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018011,GO:0018012,GO:0018022,GO:0018023,GO:0018193,GO:0018194,GO:0018205,GO:0019538,GO:0031365,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
CMS3_k127_4044360_5	1382306.JNIM01000001_gene360	1.349e-110	370.0	COG0484@1|root,COG0484@2|Bacteria,2G5NV@200795|Chloroflexi	200795|Chloroflexi	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
CMS3_k127_4044360_17	649831.L083_6959	5.674e-35	151.0	COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,4DCR5@85008|Micromonosporales	201174|Actinobacteria	T	Tyrosine phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Y_phosphatase3
CMS3_k127_4044360_20	1463920.JOGB01000001_gene3429	2.527e-32	136.0	COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria	201174|Actinobacteria	T	Protein tyrosine serine phosphatase	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_10,Y_phosphatase3
CMS3_k127_4044360_1	525904.Tter_1750	1.78e-259	814.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
CMS3_k127_4044360_18	383372.Rcas_4391	1.004e-33	139.0	COG0576@1|root,COG0576@2|Bacteria,2G77I@200795|Chloroflexi,375MV@32061|Chloroflexia	32061|Chloroflexia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
CMS3_k127_4044360_9	383372.Rcas_4390	1.326e-66	240.0	COG1420@1|root,COG1420@2|Bacteria,2G6AQ@200795|Chloroflexi,374VS@32061|Chloroflexia	32061|Chloroflexia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA
CMS3_k127_4044360_21	926569.ANT_20740	3.953e-30	129.0	COG1595@1|root,COG1595@2|Bacteria,2G6X7@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_4044360_6	525904.Tter_1645	3.599e-97	328.0	COG0332@1|root,COG0332@2|Bacteria,2NNX5@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS3_k127_4044360_10	324602.Caur_1116	5.33e-66	246.0	COG0304@1|root,COG0304@2|Bacteria,2G5K7@200795|Chloroflexi,374W7@32061|Chloroflexia	32061|Chloroflexia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS3_k127_4044360_19	357808.RoseRS_3116	3.512e-33	137.0	COG2220@1|root,COG2220@2|Bacteria,2G6IQ@200795|Chloroflexi,375G8@32061|Chloroflexia	32061|Chloroflexia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CMS3_k127_4044360_14	926550.CLDAP_04380	1.642e-40	165.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2G6Q7@200795|Chloroflexi	200795|Chloroflexi	M	Peptidoglycan-binding LysM	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23,SH3_3
CMS3_k127_4045084_0	1340493.JNIF01000003_gene2232	2.077e-154	511.0	COG1529@1|root,COG1529@2|Bacteria,3Y3J7@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K00256	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS3_k127_4045084_2	1121405.dsmv_1329	4.916e-42	170.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,4309M@68525|delta/epsilon subdivisions,2WV9K@28221|Deltaproteobacteria,2MPHP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CMS3_k127_4045084_1	234267.Acid_0086	3.838e-72	256.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
CMS3_k127_4047418_12	926550.CLDAP_06490	9.9e-64	221.0	COG1529@1|root,COG1529@2|Bacteria,2G65D@200795|Chloroflexi	200795|Chloroflexi	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS3_k127_4047418_14	221288.JH992901_gene4311	9.598e-63	229.0	COG2227@1|root,COG2227@2|Bacteria,1GQZP@1117|Cyanobacteria,1JKUR@1189|Stigonemataceae	1117|Cyanobacteria	H	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_4047418_21	994479.GL877878_gene1235	8.121e-41	160.0	COG3797@1|root,COG3797@2|Bacteria,2GPDB@201174|Actinobacteria,4E66I@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
CMS3_k127_4047418_8	1333998.M2A_1300	4.94e-83	289.0	COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2U36X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS3_k127_4047418_4	1313172.YM304_24720	2.93e-101	342.0	2BYTM@1|root,2Z7KC@2|Bacteria,2GJ6K@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4047418_11	661478.OP10G_1632	3.512e-66	237.0	COG1273@1|root,COG1273@2|Bacteria	2|Bacteria	M	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
CMS3_k127_4047418_1	1123073.KB899242_gene946	8.197e-229	741.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,1RQ06@1236|Gammaproteobacteria,1X3QM@135614|Xanthomonadales	135614|Xanthomonadales	L	DNA ligase	lig3	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
CMS3_k127_4047418_6	985054.JQEZ01000001_gene2494	5.263e-90	315.0	COG2128@1|root,COG2128@2|Bacteria,1N82C@1224|Proteobacteria,2TQXY@28211|Alphaproteobacteria,4NDRU@97050|Ruegeria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3179
CMS3_k127_4047418_17	765912.Thimo_2547	9.66e-50	191.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1WXND@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CMS3_k127_4047418_28	1463936.JOJI01000067_gene7165	7.596e-11	74.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS3_k127_4047418_32	479433.Caci_4687	1.261e-06	59.0	COG1940@1|root,COG1940@2|Bacteria,2GNFJ@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,MarR_2,ROK
CMS3_k127_4047418_2	1382306.JNIM01000001_gene274	8.636e-184	592.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G6X3@200795|Chloroflexi	200795|Chloroflexi	H	NAD synthase	-	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
CMS3_k127_4047418_19	234267.Acid_6905	3.901e-45	188.0	COG3336@1|root,COG3336@2|Bacteria,3Y6N7@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
CMS3_k127_4047418_30	1382356.JQMP01000004_gene57	4.448e-10	71.0	2EKS3@1|root,33EFV@2|Bacteria,2GBBM@200795|Chloroflexi,27YP9@189775|Thermomicrobia	189775|Thermomicrobia	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
CMS3_k127_4047418_16	1379270.AUXF01000002_gene1827	4.295e-55	203.0	COG1845@1|root,COG1845@2|Bacteria,1ZT8Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
CMS3_k127_4047418_0	479434.Sthe_1583	1.849e-240	756.0	COG0843@1|root,COG0843@2|Bacteria,2G5XS@200795|Chloroflexi,27XSC@189775|Thermomicrobia	189775|Thermomicrobia	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
CMS3_k127_4047418_7	479434.Sthe_1582	3.595e-88	304.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,2G6C0@200795|Chloroflexi,27XKX@189775|Thermomicrobia	189775|Thermomicrobia	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
CMS3_k127_4047418_25	869210.Marky_1973	2.283e-24	111.0	COG0526@1|root,COG0526@2|Bacteria,1WJ2P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	CO	periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily	ccmG	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
CMS3_k127_4047418_33	1263831.F543_6500	0.0001528	51.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,1S5VA@1236|Gammaproteobacteria,1Y8F5@135625|Pasteurellales	135625|Pasteurellales	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
CMS3_k127_4047418_3	309801.trd_1222	1.843e-149	497.0	COG1138@1|root,COG1138@2|Bacteria,2G5SZ@200795|Chloroflexi,27Y17@189775|Thermomicrobia	189775|Thermomicrobia	O	Cytochrome c-type biogenesis protein CcmF C-terminal	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
CMS3_k127_4047418_29	1238182.C882_3281	2.462e-10	72.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2U96P@28211|Alphaproteobacteria,2JSQ1@204441|Rhodospirillales	204441|Rhodospirillales	P	subunit of a heme lyase	cycL	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
CMS3_k127_4047418_27	309801.trd_0263	7.099e-14	83.0	COG2010@1|root,COG2010@2|Bacteria,2G741@200795|Chloroflexi,27XRI@189775|Thermomicrobia	189775|Thermomicrobia	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_4047418_22	589924.Ferp_0351	6.974e-40	165.0	COG1131@1|root,arCOG00194@2157|Archaea,2XXA3@28890|Euryarchaeota,2467K@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC transporter	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
CMS3_k127_4047418_24	552811.Dehly_0439	4.905e-25	120.0	COG2386@1|root,COG2386@2|Bacteria,2G6TN@200795|Chloroflexi	200795|Chloroflexi	O	PFAM cytochrome c-type biogenesis protein CcmB	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
CMS3_k127_4047418_15	309801.trd_1217	1.639e-59	215.0	COG0755@1|root,COG0755@2|Bacteria,2G6SI@200795|Chloroflexi,27Y6D@189775|Thermomicrobia	189775|Thermomicrobia	O	Cytochrome C assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
CMS3_k127_4047418_23	1382356.JQMP01000001_gene706	1.563e-36	151.0	COG0109@1|root,COG1612@1|root,COG0109@2|Bacteria,COG1612@2|Bacteria,2G5UC@200795|Chloroflexi,27XHZ@189775|Thermomicrobia	189775|Thermomicrobia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	COX15-CtaA,UbiA
CMS3_k127_4047418_10	469383.Cwoe_1908	5.89e-72	263.0	COG0109@1|root,COG0109@2|Bacteria,2GJMY@201174|Actinobacteria,4CS5J@84995|Rubrobacteria	84995|Rubrobacteria	O	UbiA prenyltransferase family	-	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
CMS3_k127_4047418_20	479434.Sthe_2670	3.229e-44	178.0	COG0842@1|root,COG0842@2|Bacteria,2G6II@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
CMS3_k127_4047418_9	1278073.MYSTI_01725	9.004e-76	267.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2YUI5@29|Myxococcales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
CMS3_k127_4047418_26	999415.HMPREF9943_00416	1.565e-20	102.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,3VQZY@526524|Erysipelotrichia	526524|Erysipelotrichia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
CMS3_k127_4047418_18	1121468.AUBR01000004_gene116	1.014e-47	181.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,42FAQ@68295|Thermoanaerobacterales	186801|Clostridia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
CMS3_k127_4047418_5	1174504.AJTN02000035_gene3043	5.861e-93	319.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HC4S@91061|Bacilli,1ZQZX@1386|Bacillus	91061|Bacilli	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_4047418_31	1521187.JPIM01000178_gene2397	1.536e-08	67.0	COG3103@1|root,COG3103@2|Bacteria,2G7IJ@200795|Chloroflexi,377K8@32061|Chloroflexia	32061|Chloroflexia	T	PFAM SH3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
CMS3_k127_4047418_13	649638.Trad_1966	8.513e-63	225.0	COG1814@1|root,COG1814@2|Bacteria,1WMZB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
CMS3_k127_4087050_2	570952.ATVH01000014_gene2261	1.938e-125	411.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2TQQ2@28211|Alphaproteobacteria,2JPBY@204441|Rhodospirillales	204441|Rhodospirillales	I	COG2030 Acyl dehydratase	-	-	4.2.1.148	ko:K14449	ko00630,ko00660,ko00720,ko01120,ko01200,map00630,map00660,map00720,map01120,map01200	M00373,M00376,M00740	R05076	RC01984	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
CMS3_k127_4087050_7	1353531.AZNX01000002_gene5249	1.146e-06	56.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,4BE9J@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Lactoylglutathione lyase	gloA	GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
CMS3_k127_4087050_1	219305.MCAG_01805	6.998e-134	445.0	COG0446@1|root,COG0446@2|Bacteria,2H7WY@201174|Actinobacteria,4D8GY@85008|Micromonosporales	201174|Actinobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
CMS3_k127_4087050_3	1380763.BG53_13295	8.122e-106	357.0	COG0320@1|root,COG0320@2|Bacteria,1TQM4@1239|Firmicutes,4H9SW@91061|Bacilli,26QKD@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
CMS3_k127_4087050_5	326427.Cagg_1130	7.427e-45	173.0	COG0321@1|root,COG0321@2|Bacteria,2G8KT@200795|Chloroflexi,375KR@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
CMS3_k127_4087050_4	1303518.CCALI_02179	9.571e-46	177.0	COG1387@1|root,COG1387@2|Bacteria	2|Bacteria	E	zinc ion binding	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
CMS3_k127_4087050_0	945713.IALB_2978	0.0	1198.0	COG2609@1|root,COG2609@2|Bacteria	2|Bacteria	C	pyruvate dehydrogenase (acetyl-transferring) activity	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
CMS3_k127_4087050_6	243090.RB3423	2.16e-25	116.0	COG0508@1|root,COG0508@2|Bacteria,2IY0W@203682|Planctomycetes	203682|Planctomycetes	C	COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CMS3_k127_4087068_0	926550.CLDAP_06490	4.86e-251	796.0	COG1529@1|root,COG1529@2|Bacteria,2G65D@200795|Chloroflexi	200795|Chloroflexi	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS3_k127_4147010_0	479434.Sthe_1429	5.203e-205	653.0	COG0504@1|root,COG0504@2|Bacteria,2G5U0@200795|Chloroflexi,27XSS@189775|Thermomicrobia	189775|Thermomicrobia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
CMS3_k127_4147010_2	1286171.EAL2_c03680	6.871e-77	263.0	COG0176@1|root,COG0176@2|Bacteria,1TP4Q@1239|Firmicutes,248KZ@186801|Clostridia,25V2P@186806|Eubacteriaceae	186801|Clostridia	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
CMS3_k127_4147010_1	479434.Sthe_1003	2.104e-174	560.0	COG1158@1|root,COG1158@2|Bacteria,2G5UQ@200795|Chloroflexi,27Y0Z@189775|Thermomicrobia	189775|Thermomicrobia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
CMS3_k127_4178866_2	401526.TcarDRAFT_1914	5.574e-16	91.0	COG4655@1|root,COG4655@2|Bacteria,1V25X@1239|Firmicutes,4H46N@909932|Negativicutes	909932|Negativicutes	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
CMS3_k127_4178866_3	1121472.AQWN01000010_gene596	1.486e-15	87.0	COG3745@1|root,COG3745@2|Bacteria,1V5FZ@1239|Firmicutes,24I7V@186801|Clostridia,262WB@186807|Peptococcaceae	186801|Clostridia	U	Flp pilus assembly protein RcpC/CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
CMS3_k127_4178866_1	509191.AEDB02000063_gene453	1.597e-39	166.0	COG4753@1|root,COG4963@1|root,COG4753@2|Bacteria,COG4963@2|Bacteria,1UF2S@1239|Firmicutes,248CD@186801|Clostridia,3WKMS@541000|Ruminococcaceae	186801|Clostridia	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,ParA,Response_reg
CMS3_k127_4178866_0	429009.Adeg_1041	9.662e-136	445.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,42FW4@68295|Thermoanaerobacterales	186801|Clostridia	U	PFAM Type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
CMS3_k127_4181815_5	552811.Dehly_1189	7.957e-72	248.0	COG0745@1|root,COG0745@2|Bacteria,2G6A5@200795|Chloroflexi,34D9D@301297|Dehalococcoidia	200795|Chloroflexi	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_4181815_7	926569.ANT_01750	4.19e-49	191.0	COG5002@1|root,COG5002@2|Bacteria,2G67W@200795|Chloroflexi	200795|Chloroflexi	T	PFAM ATP-binding region, ATPase domain protein	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,sCache_like
CMS3_k127_4181815_0	1246445.ANAY01000030_gene4437	2.608e-117	383.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4EM3I@85012|Streptosporangiales	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
CMS3_k127_4181815_1	926550.CLDAP_00820	1.084e-108	359.0	COG0581@1|root,COG0581@2|Bacteria,2G6BI@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
CMS3_k127_4181815_4	926550.CLDAP_00830	6.423e-103	343.0	COG0573@1|root,COG0573@2|Bacteria,2G62J@200795|Chloroflexi	200795|Chloroflexi	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
CMS3_k127_4181815_3	1128427.KB904821_gene773	1.337e-104	349.0	COG0226@1|root,COG0226@2|Bacteria,1FZZ0@1117|Cyanobacteria,1H7JB@1150|Oscillatoriales	1117|Cyanobacteria	P	Phosphate ABC transporter substrate-binding protein, PhoT family	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like,PBP_like_2
CMS3_k127_4181815_6	1382356.JQMP01000004_gene657	4.313e-64	227.0	COG0704@1|root,COG0704@2|Bacteria,2G6HD@200795|Chloroflexi,27XPS@189775|Thermomicrobia	189775|Thermomicrobia	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
CMS3_k127_4181815_8	479434.Sthe_3066	2.157e-35	139.0	COG3467@1|root,COG3467@2|Bacteria,2G70M@200795|Chloroflexi	200795|Chloroflexi	S	PFAM pyridoxamine 5'-phosphate oxidase-related	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_4181815_12	1268622.AVS7_02068	4.135e-10	69.0	COG2030@1|root,COG2030@2|Bacteria,1NAYM@1224|Proteobacteria,2VYVZ@28216|Betaproteobacteria,4AFWC@80864|Comamonadaceae	28216|Betaproteobacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
CMS3_k127_4181815_9	269800.Tfu_1483	1.445e-16	87.0	COG2030@1|root,COG2030@2|Bacteria,2IPRC@201174|Actinobacteria,4ENYB@85012|Streptosporangiales	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
CMS3_k127_4181815_2	1348657.M622_02900	1.868e-108	363.0	COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2VQG6@28216|Betaproteobacteria	28216|Betaproteobacteria	S	2-Nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
CMS3_k127_4181815_10	1348657.M622_02910	3.712e-16	81.0	COG2086@1|root,COG2086@2|Bacteria	2|Bacteria	C	electron transfer activity	ygcR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
CMS3_k127_4188392_2	298653.Franean1_4337	3.61e-22	112.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_4188392_1	1289387.AUKW01000009_gene4373	8.355e-69	243.0	COG1136@1|root,COG1136@2|Bacteria,2GJQV@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_4188392_0	1333998.M2A_2493	8.599e-93	309.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,4BTBG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_4191783_2	439235.Dalk_3191	3.892e-30	124.0	COG1028@1|root,COG1545@1|root,COG3255@1|root,COG3425@1|root,COG1028@2|Bacteria,COG1545@2|Bacteria,COG3255@2|Bacteria,COG3425@2|Bacteria,1MXNQ@1224|Proteobacteria,42Q8V@68525|delta/epsilon subdivisions,2WJP0@28221|Deltaproteobacteria,2MHRA@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III_C,DUF35_N,MaoC_dehydrat_N,MaoC_dehydratas,OB_aCoA_assoc,SCP2,adh_short
CMS3_k127_4191783_3	1033991.RLEG12_32015	7.236e-28	118.0	COG0454@1|root,COG0454@2|Bacteria,1RBP2@1224|Proteobacteria,2UDPX@28211|Alphaproteobacteria,4BNQX@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_4191783_1	1957.JODX01000012_gene368	1.641e-48	181.0	COG0346@1|root,COG0346@2|Bacteria,2GRGB@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
CMS3_k127_4191783_5	1283287.KB822577_gene3431	6.966e-16	91.0	COG0239@1|root,COG0239@2|Bacteria,2IKM1@201174|Actinobacteria,4DSBC@85009|Propionibacteriales	201174|Actinobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB1	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
CMS3_k127_4191783_0	317936.Nos7107_5285	1.408e-146	470.0	COG0667@1|root,COG0667@2|Bacteria,1G3WV@1117|Cyanobacteria,1HMPK@1161|Nostocales	1117|Cyanobacteria	C	PFAM aldo keto reductase	-	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
CMS3_k127_4191783_4	693986.MOC_3895	1.987e-26	115.0	COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2TU6K@28211|Alphaproteobacteria,1JRQM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
CMS3_k127_419617_1	479434.Sthe_0728	9.432e-118	392.0	COG0019@1|root,COG0019@2|Bacteria,2G5RR@200795|Chloroflexi,27XZ6@189775|Thermomicrobia	189775|Thermomicrobia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
CMS3_k127_419617_3	1521187.JPIM01000066_gene2676	5.213e-56	209.0	COG0470@1|root,COG0470@2|Bacteria,2GBJM@200795|Chloroflexi,375AT@32061|Chloroflexia	32061|Chloroflexia	L	DNA polymerase III, delta subunit, C terminal	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
CMS3_k127_419617_4	255470.cbdbA510	1.077e-45	180.0	COG1774@1|root,COG1774@2|Bacteria,2G6AJ@200795|Chloroflexi,34D5Z@301297|Dehalococcoidia	301297|Dehalococcoidia	S	PSP1 C-terminal conserved region	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
CMS3_k127_419617_5	309801.trd_1172	1.462e-40	161.0	COG2897@1|root,COG2897@2|Bacteria,2G5XI@200795|Chloroflexi,27XNT@189775|Thermomicrobia	189775|Thermomicrobia	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
CMS3_k127_419617_2	479434.Sthe_2028	9.505e-90	312.0	COG0612@1|root,COG0612@2|Bacteria,2G672@200795|Chloroflexi,27XSH@189775|Thermomicrobia	189775|Thermomicrobia	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_419617_0	309801.trd_1300	3.25e-206	654.0	COG0459@1|root,COG0459@2|Bacteria,2G65N@200795|Chloroflexi,27Y1U@189775|Thermomicrobia	189775|Thermomicrobia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS3_k127_419617_6	517418.Ctha_1617	9.214e-24	105.0	COG0234@1|root,COG0234@2|Bacteria,1FE2T@1090|Chlorobi	1090|Chlorobi	J	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
CMS3_k127_419617_7	306281.AJLK01000019_gene3725	3.479e-10	67.0	COG2944@1|root,COG2944@2|Bacteria,1G6V7@1117|Cyanobacteria	1117|Cyanobacteria	K	helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS3_k127_419617_8	1166018.FAES_1228	1.104e-09	70.0	28HQ3@1|root,2Z7XW@2|Bacteria,4NF9H@976|Bacteroidetes,47KPJ@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF2851)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2851
CMS3_k127_4198052_0	1122222.AXWR01000035_gene208	8.605e-132	427.0	COG0520@1|root,COG0520@2|Bacteria,1WIPV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_4198052_3	479434.Sthe_0455	8.122e-85	293.0	COG2355@1|root,COG2355@2|Bacteria,2G8C9@200795|Chloroflexi,27XYN@189775|Thermomicrobia	189775|Thermomicrobia	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
CMS3_k127_4198052_4	1283283.ATXA01000014_gene3563	1.802e-81	280.0	COG1024@1|root,COG1024@2|Bacteria,2IBN1@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_4198052_2	1179773.BN6_10750	3.823e-97	334.0	COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,4E0MM@85010|Pseudonocardiales	201174|Actinobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
CMS3_k127_4198052_10	1114959.SZMC14600_06812	1.041e-26	117.0	COG1247@1|root,COG1247@2|Bacteria,2GR9D@201174|Actinobacteria,4EF6Z@85010|Pseudonocardiales	201174|Actinobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_4198052_8	1304865.JAGF01000001_gene2920	3.078e-38	155.0	COG0842@1|root,COG0842@2|Bacteria,2IITR@201174|Actinobacteria	201174|Actinobacteria	V	Abc-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CMS3_k127_4198052_7	1246995.AFR_36830	2.613e-55	205.0	COG0842@1|root,COG0842@2|Bacteria,2IITR@201174|Actinobacteria	201174|Actinobacteria	V	Abc-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CMS3_k127_4198052_1	1304865.JAGF01000001_gene2921	1.25e-107	358.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4F0HN@85016|Cellulomonadaceae	201174|Actinobacteria	V	TIGRFAM daunorubicin resistance ABC transporter ATPase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC_tran
CMS3_k127_4198052_9	264198.Reut_B3708	2.551e-30	129.0	COG1024@1|root,COG1024@2|Bacteria,1NZ0X@1224|Proteobacteria	1224|Proteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_4198052_5	1382356.JQMP01000003_gene2367	1.72e-72	259.0	COG0624@1|root,COG0624@2|Bacteria,2G63E@200795|Chloroflexi,27Y1X@189775|Thermomicrobia	189775|Thermomicrobia	E	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS3_k127_4198052_6	1380394.JADL01000002_gene1116	6.59e-62	219.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,2JR0D@204441|Rhodospirillales	204441|Rhodospirillales	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_4207798_1	743719.PaelaDRAFT_2659	1.057e-50	186.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,4H9KQ@91061|Bacilli,26SMA@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0004425,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
CMS3_k127_4207798_0	479434.Sthe_1875	5.297e-62	224.0	COG0134@1|root,COG0134@2|Bacteria,2G6GG@200795|Chloroflexi,27XGP@189775|Thermomicrobia	189775|Thermomicrobia	E	Indole-3-glycerol phosphate synthase	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
CMS3_k127_4218863_1	1123504.JQKD01000012_gene1257	5.402e-30	129.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VN0B@28216|Betaproteobacteria,4AH2J@80864|Comamonadaceae	28216|Betaproteobacteria	C	CoA-transferase family III	bbsE	-	2.8.3.15	ko:K07543	ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220	M00418	R05588	RC00014,RC00137	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
CMS3_k127_4218863_0	42256.RradSPS_2237	2.633e-54	200.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,4CQAE@84995|Rubrobacteria	84995|Rubrobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_4234237_1	479434.Sthe_1663	7.913e-37	153.0	COG3359@1|root,COG3359@2|Bacteria	2|Bacteria	L	RNase_H superfamily	yprB	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
CMS3_k127_4234237_0	1047013.AQSP01000062_gene1209	1.227e-57	221.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	XK27_02215	-	3.4.21.96	ko:K01361	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I9,PA,Peptidase_S8,SLH,YSIRK_signal,fn3_5
CMS3_k127_4234237_2	311424.DhcVS_1130	1.432e-26	117.0	COG1595@1|root,COG1595@2|Bacteria,2G6X7@200795|Chloroflexi,34D3G@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
CMS3_k127_425331_0	1242864.D187_003976	3.117e-37	147.0	COG1073@1|root,COG1073@2|Bacteria,1NY60@1224|Proteobacteria	1224|Proteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_425331_1	479434.Sthe_2061	1.916e-09	66.0	COG0449@1|root,COG0449@2|Bacteria,2G5V6@200795|Chloroflexi,27XY2@189775|Thermomicrobia	189775|Thermomicrobia	M	SIS domain	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
CMS3_k127_4265246_0	926550.CLDAP_27350	5.615e-99	333.0	COG2421@1|root,COG2421@2|Bacteria,2G63Y@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Acetamidase Formamidase	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
CMS3_k127_4265728_1	1382304.JNIL01000001_gene1627	2.013e-18	90.0	2CIA1@1|root,3413B@2|Bacteria,1VXTX@1239|Firmicutes,4HXI2@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4265728_0	1382306.JNIM01000001_gene3473	1.904e-115	379.0	COG2897@1|root,COG2897@2|Bacteria,2G5XI@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
CMS3_k127_4265728_2	1382306.JNIM01000001_gene1035	3.324e-14	72.0	COG0031@1|root,COG0031@2|Bacteria,2G698@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738,ko:K12339	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03132,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_4301036_7	463191.SSEG_00773	1.919e-24	109.0	COG4589@1|root,COG4589@2|Bacteria,2I7ZB@201174|Actinobacteria	201174|Actinobacteria	S	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
CMS3_k127_4301036_5	390989.JOEG01000012_gene3462	1.965e-28	124.0	COG0204@1|root,COG0204@2|Bacteria,2IAXZ@201174|Actinobacteria	201174|Actinobacteria	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS3_k127_4301036_10	1385521.N803_16790	2.319e-13	80.0	COG2755@1|root,COG2755@2|Bacteria,2IC8X@201174|Actinobacteria,4FI2P@85021|Intrasporangiaceae	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS3_k127_4301036_8	1463934.JOCF01000002_gene3047	4.135e-22	103.0	arCOG11428@1|root,33YIA@2|Bacteria,2ISD0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4301036_2	485913.Krac_5292	6.392e-45	167.0	COG0237@1|root,COG0237@2|Bacteria	2|Bacteria	H	dephospho-CoA kinase activity	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_18,CoaE
CMS3_k127_4301036_0	1297865.APJD01000020_gene97	5.106e-51	191.0	COG0030@1|root,COG0030@2|Bacteria,1R0K7@1224|Proteobacteria,2U8JF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Ribosomal RNA adenine dimethylase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_4301036_9	497964.CfE428DRAFT_0420	5.64e-21	98.0	2AY99@1|root,31QBJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4301036_6	1158756.AQXQ01000012_gene1625	5.335e-27	130.0	COG5001@1|root,COG5001@2|Bacteria,1RC0H@1224|Proteobacteria	1224|Proteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,GGDEF,PAS_3,PAS_4,PAS_9
CMS3_k127_4301036_3	1089550.ATTH01000001_gene1576	1.246e-41	158.0	COG0652@1|root,COG0652@2|Bacteria,4PM5K@976|Bacteroidetes,1FJNB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	HEAT,HEAT_2,Pro_isomerase
CMS3_k127_4301036_1	485913.Krac_12126	1.665e-46	180.0	COG0652@1|root,COG0652@2|Bacteria,2G69B@200795|Chloroflexi	200795|Chloroflexi	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
CMS3_k127_4301036_4	146922.JOFU01000017_gene3620	5.087e-36	140.0	COG0596@1|root,COG0596@2|Bacteria,2GK79@201174|Actinobacteria	201174|Actinobacteria	K	epoxide hydrolase	-	-	-	ko:K21159	ko01059,map01059	-	-	-	ko00000,ko00001	-	-	-	EHN
CMS3_k127_4308788_7	414684.RC1_1865	1.161e-90	302.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria,2JP9U@204441|Rhodospirillales	204441|Rhodospirillales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
CMS3_k127_4308788_5	42256.RradSPS_1262	1.477e-104	347.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the LDH MDH superfamily. LDH family	mdh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
CMS3_k127_4308788_0	1110502.TMO_1136	3.562e-208	656.0	COG0538@1|root,COG0538@2|Bacteria,1MUIB@1224|Proteobacteria,2TQWD@28211|Alphaproteobacteria,2JQ2K@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the isocitrate and isopropylmalate dehydrogenases family	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CMS3_k127_4308788_1	797209.ZOD2009_19363	8.53e-192	614.0	COG4799@1|root,arCOG02705@2157|Archaea,2XSVM@28890|Euryarchaeota,23T6H@183963|Halobacteria	183963|Halobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	pccB2	GO:0003674,GO:0003824,GO:0004658,GO:0016421,GO:0016874,GO:0016885	2.1.3.15,6.4.1.2,6.4.1.3	ko:K19312	ko00280,ko00630,ko00640,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01120,map01130,map01200	M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
CMS3_k127_4308788_13	483219.LILAB_09475	8.137e-12	74.0	COG1388@1|root,COG3179@1|root,COG1388@2|Bacteria,COG3179@2|Bacteria,1MYUR@1224|Proteobacteria,42UGP@68525|delta/epsilon subdivisions,2WWB8@28221|Deltaproteobacteria,2YZ5E@29|Myxococcales	28221|Deltaproteobacteria	M	Chitinase class I	-	-	-	ko:K03791	-	-	-	-	ko00000	-	GH19	-	Glyco_hydro_19,LysM,PG_binding_1
CMS3_k127_4308788_10	221288.JH992901_gene612	2.321e-40	166.0	COG2234@1|root,COG2234@2|Bacteria,1G4A2@1117|Cyanobacteria,1JI76@1189|Stigonemataceae	1117|Cyanobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
CMS3_k127_4308788_3	518766.Rmar_1062	1.756e-171	565.0	COG0146@1|root,COG0146@2|Bacteria,4PM5E@976|Bacteroidetes,1FJR8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
CMS3_k127_4308788_2	479434.Sthe_2481	9.177e-177	575.0	COG0145@1|root,COG0145@2|Bacteria,2G5KZ@200795|Chloroflexi,27XUM@189775|Thermomicrobia	189775|Thermomicrobia	EQ	Hydantoinaseoxoprolinase domain protein	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
CMS3_k127_4308788_12	1382306.JNIM01000001_gene3871	5.575e-31	131.0	COG1825@1|root,COG1825@2|Bacteria,2G6YX@200795|Chloroflexi	200795|Chloroflexi	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
CMS3_k127_4308788_6	1229909.NSED_07540	4.072e-95	327.0	COG0731@1|root,arCOG00953@2157|Archaea	2157|Archaea	C	Radical SAM domain protein	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
CMS3_k127_4308788_8	234267.Acid_2747	6.66e-69	245.0	COG0223@1|root,COG0223@2|Bacteria,3Y32C@57723|Acidobacteria	57723|Acidobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
CMS3_k127_4308788_9	357808.RoseRS_0725	2.915e-63	237.0	COG0747@1|root,COG0747@2|Bacteria,2G5NC@200795|Chloroflexi,375DK@32061|Chloroflexia	32061|Chloroflexia	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_4308788_14	485913.Krac_8434	1.507e-05	49.0	COG1314@1|root,COG1314@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
CMS3_k127_4308788_4	251221.35214738	1.083e-113	381.0	COG0391@1|root,COG0391@2|Bacteria,1G0R0@1117|Cyanobacteria	1117|Cyanobacteria	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
CMS3_k127_4308788_11	1034769.KB910518_gene197	3.291e-32	130.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,4HAFB@91061|Bacilli,26R27@186822|Paenibacillaceae	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
CMS3_k127_4319577_2	326427.Cagg_2191	2.891e-63	240.0	COG1840@1|root,COG2304@1|root,COG1840@2|Bacteria,COG2304@2|Bacteria,2G8ES@200795|Chloroflexi,3759V@32061|Chloroflexia	32061|Chloroflexia	P	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	SBP_bac_11,VWA
CMS3_k127_4319577_7	1298593.TOL_0070	3.163e-31	137.0	COG3853@1|root,COG3853@2|Bacteria,1MY18@1224|Proteobacteria,1RZ1H@1236|Gammaproteobacteria,1XMQ5@135619|Oceanospirillales	135619|Oceanospirillales	P	Toxic anion resistance	-	-	-	-	-	-	-	-	-	-	-	-	TelA
CMS3_k127_4319577_3	573061.Clocel_1063	1.314e-61	220.0	COG1082@1|root,COG1082@2|Bacteria,1VFCG@1239|Firmicutes,24D46@186801|Clostridia,36IYJ@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS3_k127_4319577_5	272943.RSP_3491	8.991e-46	176.0	COG3409@1|root,COG3409@2|Bacteria,1P328@1224|Proteobacteria,2TTJK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,Peptidase_M15_4
CMS3_k127_4319577_10	1442599.JAAN01000072_gene825	3.905e-10	70.0	COG1876@1|root,COG3409@1|root,COG1876@2|Bacteria,COG3409@2|Bacteria,1NAYN@1224|Proteobacteria,1SYR5@1236|Gammaproteobacteria,1XCSN@135614|Xanthomonadales	135614|Xanthomonadales	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	ko:K17733	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M15_4
CMS3_k127_4319577_6	1463845.JOIG01000003_gene4980	4.669e-38	152.0	COG2356@1|root,COG2356@2|Bacteria,2GJ38@201174|Actinobacteria	201174|Actinobacteria	L	Protein of unknown function (DUF1524)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1524
CMS3_k127_4319577_8	153948.NAL212_1118	5.165e-29	131.0	28MCN@1|root,2ZAQR@2|Bacteria,1N00X@1224|Proteobacteria,2VV0N@28216|Betaproteobacteria,373FE@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4319577_9	1317122.ATO12_02615	1.778e-27	130.0	COG0823@1|root,COG0823@2|Bacteria,4NYXJ@976|Bacteroidetes,1IHT2@117743|Flavobacteriia,2YJBR@290174|Aquimarina	976|Bacteroidetes	U	Domain of unknown function (DUF5050)	-	-	-	-	-	-	-	-	-	-	-	-	PD40
CMS3_k127_4319577_4	1380390.JIAT01000009_gene838	1.129e-58	211.0	COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,2I98A@201174|Actinobacteria,4CSYC@84995|Rubrobacteria	84995|Rubrobacteria	K	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,Rhodanese
CMS3_k127_4319577_1	265072.Mfla_1551	5.203e-95	317.0	COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2VK8F@28216|Betaproteobacteria,2KKTY@206350|Nitrosomonadales	206350|Nitrosomonadales	O	C-terminal domain of 1-Cys peroxiredoxin	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
CMS3_k127_4319577_0	1283300.ATXB01000001_gene1800	1.047e-155	501.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria,1XDMT@135618|Methylococcales	1236|Gammaproteobacteria	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_43200_6	644283.Micau_0115	5.641e-26	113.0	COG0748@1|root,COG0748@2|Bacteria,2I6WT@201174|Actinobacteria,4DMTT@85008|Micromonosporales	201174|Actinobacteria	P	coenzyme F420 binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_43200_2	1121430.JMLG01000001_gene2125	1.443e-60	218.0	COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,260XY@186807|Peptococcaceae	186801|Clostridia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
CMS3_k127_43200_4	1238182.C882_2396	2.092e-41	164.0	COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,2TUA2@28211|Alphaproteobacteria,2JQ5Y@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_43200_7	1122180.Lokhon_00166	1.047e-23	110.0	COG1028@1|root,COG1028@2|Bacteria,1PHIQ@1224|Proteobacteria,2V7SR@28211|Alphaproteobacteria,2P9PK@245186|Loktanella	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_43200_0	1280944.HY17_09545	1.319e-87	300.0	COG1024@1|root,COG1024@2|Bacteria,1PK10@1224|Proteobacteria,2TS4M@28211|Alphaproteobacteria,43Y1C@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_43200_3	350054.Mflv_1263	2.574e-48	183.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,236CE@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
CMS3_k127_43200_5	1122132.AQYH01000008_gene2631	2.889e-36	148.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TTVF@28211|Alphaproteobacteria,4BAWQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	idnO	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0008874,GO:0008875,GO:0016491,GO:0016614,GO:0016616,GO:0036094,GO:0042802,GO:0042803,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
CMS3_k127_43200_8	452652.KSE_30580	4.847e-08	63.0	COG1714@1|root,COG1714@2|Bacteria,2HGSH@201174|Actinobacteria,2M38S@2063|Kitasatospora	201174|Actinobacteria	S	RDD family	pra	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	RDD
CMS3_k127_43200_1	518766.Rmar_2036	1.141e-60	218.0	COG1028@1|root,COG1028@2|Bacteria,4NGR3@976|Bacteroidetes,1FIP0@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
CMS3_k127_4320734_3	448385.sce3333	5.17e-11	64.0	COG0667@1|root,COG0667@2|Bacteria,1PDY4@1224|Proteobacteria,434SZ@68525|delta/epsilon subdivisions,2WZ41@28221|Deltaproteobacteria,2Z19Y@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS3_k127_4320734_0	469383.Cwoe_1286	8.542e-92	324.0	COG1520@1|root,COG4993@1|root,COG1520@2|Bacteria,COG4993@2|Bacteria,2IAZ2@201174|Actinobacteria	201174|Actinobacteria	KLT	PQQ enzyme repeat	-	-	1.1.2.6,2.7.11.1	ko:K05889,ko:K12132	-	-	R03136	-	ko00000,ko01000,ko01001	-	-	-	PQQ,PQQ_2,PQQ_3,Pkinase
CMS3_k127_4320734_1	1306406.ASHX01000001_gene4050	1.188e-82	287.0	COG4447@1|root,COG4447@2|Bacteria,2GM8J@201174|Actinobacteria	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR_6
CMS3_k127_4320734_4	1502850.FG91_03639	1.001e-06	61.0	COG3173@1|root,COG3173@2|Bacteria,1R7XK@1224|Proteobacteria,2TTWB@28211|Alphaproteobacteria,2K39Q@204457|Sphingomonadales	204457|Sphingomonadales	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase
CMS3_k127_4320734_2	1118054.CAGW01000047_gene1590	4.725e-42	166.0	COG0683@1|root,COG0683@2|Bacteria,1V4XA@1239|Firmicutes,4HYGJ@91061|Bacilli	91061|Bacilli	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
CMS3_k127_4331742_2	1449355.JQNR01000003_gene356	6.575e-70	252.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
CMS3_k127_4331742_1	1382306.JNIM01000001_gene623	1.661e-97	332.0	COG2124@1|root,COG2124@2|Bacteria,2G7SX@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
CMS3_k127_4331742_0	390989.JOEG01000041_gene2934	6.468e-111	389.0	COG0038@1|root,COG0038@2|Bacteria,2GPPN@201174|Actinobacteria,4DBG8@85008|Micromonosporales	201174|Actinobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
CMS3_k127_4331742_3	1211114.ALIP01000040_gene2943	3.353e-35	139.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,1X72T@135614|Xanthomonadales	135614|Xanthomonadales	FG	Histidine triad (HIT) protein	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
CMS3_k127_44333_1	502025.Hoch_5487	7.011e-83	280.0	COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,42Q93@68525|delta/epsilon subdivisions,2WKAA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Mandelate racemase muconate lactonizing	-	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
CMS3_k127_44333_2	105425.BBPL01000012_gene1986	3.531e-12	72.0	COG3467@1|root,COG3467@2|Bacteria,2IFRI@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
CMS3_k127_44333_0	1382304.JNIL01000001_gene3453	1.761e-118	398.0	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,4HC54@91061|Bacilli	91061|Bacilli	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS3_k127_444606_4	279010.BL03012	0.0001134	46.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,4HBEA@91061|Bacilli,1ZAY4@1386|Bacillus	91061|Bacilli	C	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit	acoA	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
CMS3_k127_444606_1	1121472.AQWN01000007_gene1130	2.965e-116	383.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,25ZZC@186807|Peptococcaceae	186801|Clostridia	C	PFAM Transketolase	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS3_k127_444606_2	1394178.AWOO02000019_gene7620	3.05e-68	248.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria,4EN87@85012|Streptosporangiales	201174|Actinobacteria	C	e3 binding domain	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CMS3_k127_444606_3	926569.ANT_10990	8.309e-15	80.0	COG0664@1|root,COG0664@2|Bacteria,2G92E@200795|Chloroflexi	200795|Chloroflexi	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
CMS3_k127_444606_0	1380390.JIAT01000009_gene522	7.55e-268	836.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4CP9R@84995|Rubrobacteria	84995|Rubrobacteria	T	Elongation factor G C-terminus	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
CMS3_k127_444606_5	926560.KE387023_gene3326	0.000357	50.0	COG4257@1|root,COG4257@2|Bacteria	2|Bacteria	V	antibiotic catabolic process	vgb	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	DUF5011
CMS3_k127_4472687_20	1095769.CAHF01000006_gene1956	2.206e-12	71.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,475Y7@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_4472687_22	1405498.SSIM_03365	9.077e-06	56.0	COG0775@1|root,COG0775@2|Bacteria,1U7WK@1239|Firmicutes,4HB8K@91061|Bacilli,4GXZ1@90964|Staphylococcaceae	91061|Bacilli	F	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
CMS3_k127_4472687_8	234267.Acid_3090	4.085e-61	227.0	COG1804@1|root,COG1804@2|Bacteria,3Y7RD@57723|Acidobacteria	57723|Acidobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_4472687_14	1479238.JQMZ01000001_gene959	8.299e-33	137.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria,43XF7@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_4472687_18	909663.KI867149_gene3397	1.66e-15	83.0	COG4274@1|root,COG4274@2|Bacteria,1PUJQ@1224|Proteobacteria,42XN6@68525|delta/epsilon subdivisions,2WTHH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
CMS3_k127_4472687_4	1043493.BBLU01000014_gene1312	2.569e-79	277.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS3_k127_4472687_17	426716.JOAJ01000007_gene4293	1.502e-17	97.0	COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria,4FWXB@85025|Nocardiaceae	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
CMS3_k127_4472687_1	479434.Sthe_2695	2.118e-129	444.0	COG5001@1|root,COG5001@2|Bacteria,2G7UT@200795|Chloroflexi,27Y1B@189775|Thermomicrobia	189775|Thermomicrobia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3
CMS3_k127_4472687_3	561175.KB894097_gene191	6.134e-88	300.0	COG0745@1|root,COG0745@2|Bacteria,2GKYV@201174|Actinobacteria,4EGQB@85012|Streptosporangiales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_4472687_13	1068980.ARVW01000001_gene4087	1.235e-33	136.0	COG0642@1|root,COG2205@2|Bacteria,2GJMV@201174|Actinobacteria,4DZZ8@85010|Pseudonocardiales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_4472687_11	928724.SacglDRAFT_02716	3.177e-42	162.0	COG0642@1|root,COG2205@2|Bacteria,2GJMV@201174|Actinobacteria,4DXSD@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	cutS	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_4472687_6	585531.HMPREF0063_10436	2.564e-65	232.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,4DN46@85009|Propionibacteriales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_4472687_10	1206735.BAGG01000057_gene2305	9.749e-51	199.0	COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria,4FV4F@85025|Nocardiaceae	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
CMS3_k127_4472687_2	1206731.BAGB01000054_gene3893	4.521e-101	349.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
CMS3_k127_4472687_16	1499967.BAYZ01000139_gene119	4.407e-22	101.0	COG0346@1|root,COG0346@2|Bacteria,2NPRH@2323|unclassified Bacteria	2|Bacteria	E	Glyoxalase-like domain	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
CMS3_k127_4472687_7	211165.AJLN01000141_gene2481	1.621e-61	233.0	COG0530@1|root,COG0530@2|Bacteria,1G7C1@1117|Cyanobacteria,1JJMG@1189|Stigonemataceae	1117|Cyanobacteria	P	Sodium/calcium exchanger protein	-	-	-	-	-	-	-	-	-	-	-	-	Na_Ca_ex
CMS3_k127_4472687_12	1394178.AWOO02000016_gene6846	3.459e-41	168.0	COG0454@1|root,COG0456@2|Bacteria,2I9Y3@201174|Actinobacteria,4ER9I@85012|Streptosporangiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_4472687_5	485913.Krac_2859	1.101e-73	261.0	COG2141@1|root,COG2141@2|Bacteria,2G869@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_4472687_15	287986.DV20_02125	1.039e-29	124.0	COG0346@1|root,COG0346@2|Bacteria,2H5Y5@201174|Actinobacteria,4EBMJ@85010|Pseudonocardiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_4472687_19	1279017.AQYJ01000026_gene73	1.042e-14	85.0	2DXTJ@1|root,346GW@2|Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4472687_9	1122237.AUGQ01000002_gene1785	7.523e-55	210.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4FM14@85023|Microbacteriaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_4472687_0	398525.KB900701_gene2635	8.483e-149	479.0	COG2141@1|root,COG2141@2|Bacteria,1MUVN@1224|Proteobacteria,2TR26@28211|Alphaproteobacteria,3JSBW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	MA20_06115	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_4521943_0	1172179.AUKV01000003_gene7383	2.986e-145	474.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_4521943_2	861299.J421_2147	4.404e-31	126.0	COG3795@1|root,COG3795@2|Bacteria,1ZV0M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
CMS3_k127_4521943_1	649638.Trad_0463	5.352e-75	262.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1WIPW@1297|Deinococcus-Thermus	2|Bacteria	C	PFAM FAD linked oxidase domain protein	MA20_43170	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
CMS3_k127_4577039_4	1128421.JAGA01000002_gene10	3.097e-57	214.0	COG0614@1|root,COG0614@2|Bacteria,2NPHH@2323|unclassified Bacteria	2|Bacteria	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
CMS3_k127_4577039_2	552811.Dehly_0716	1.767e-88	305.0	COG0609@1|root,COG0609@2|Bacteria,2G6E8@200795|Chloroflexi,34CYV@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
CMS3_k127_4577039_3	95619.PM1_0207870	1.611e-60	219.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,1RRII@1236|Gammaproteobacteria	1236|Gammaproteobacteria	HP	(ABC) transporter	fhuC	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS3_k127_4577039_5	765420.OSCT_2628	8.8e-55	199.0	COG2109@1|root,COG2109@2|Bacteria,2G6Q6@200795|Chloroflexi,375GV@32061|Chloroflexia	32061|Chloroflexia	H	PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
CMS3_k127_4577039_0	324602.Caur_2560	1.345e-145	486.0	COG1492@1|root,COG1492@2|Bacteria,2G5PU@200795|Chloroflexi,374TK@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	CbiA,GATase_3
CMS3_k127_4577039_1	357808.RoseRS_0559	1.276e-104	351.0	COG2038@1|root,COG2038@2|Bacteria,2G5R3@200795|Chloroflexi,376BT@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
CMS3_k127_4577039_8	580340.Tlie_0147	1.419e-26	119.0	COG0368@1|root,COG0368@2|Bacteria,3TB5W@508458|Synergistetes	508458|Synergistetes	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
CMS3_k127_4577039_6	693977.Deipr_2602	2.852e-52	190.0	COG2087@1|root,COG2087@2|Bacteria,1WMP8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	COG2087 Adenosyl cobinamide kinase adenosyl cobinamide phosphate guanylyltransferase	-	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
CMS3_k127_4577039_7	575540.Isop_2967	5.845e-51	192.0	COG0265@1|root,COG0265@2|Bacteria,2IYNW@203682|Planctomycetes	203682|Planctomycetes	O	C-terminal PDZ domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Trypsin_2
CMS3_k127_4584635_0	675635.Psed_0983	5.294e-31	125.0	COG0640@1|root,COG0640@2|Bacteria,2IR66@201174|Actinobacteria	201174|Actinobacteria	K	arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
CMS3_k127_4584635_2	67352.JODS01000043_gene1110	1.195e-07	63.0	COG2162@1|root,COG2162@2|Bacteria,2GP1R@201174|Actinobacteria	201174|Actinobacteria	Q	Belongs to the arylamine N-acetyltransferase family	-	-	2.3.1.118	ko:K00675,ko:K15466	ko01051,ko01052,map01051,map01052	-	-	-	ko00000,ko00001,ko01000,ko01008	-	-	-	Acetyltransf_2
CMS3_k127_4584635_1	292459.STH2357	4.392e-13	73.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia	186801|Clostridia	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_45905_4	1476876.JOJO01000054_gene8250	6.494e-47	181.0	COG2211@1|root,COG2211@2|Bacteria,2I3WF@201174|Actinobacteria	201174|Actinobacteria	G	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_45905_2	105559.Nwat_0489	1.244e-83	292.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1WWHU@135613|Chromatiales	135613|Chromatiales	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
CMS3_k127_45905_7	1540221.JQNI01000002_gene2897	1.415e-35	146.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
CMS3_k127_45905_0	357808.RoseRS_2947	2.02e-171	551.0	COG0154@1|root,COG0154@2|Bacteria,2G5T0@200795|Chloroflexi,375CN@32061|Chloroflexia	32061|Chloroflexia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS3_k127_45905_10	243164.DET1334	6.156e-25	107.0	COG0721@1|root,COG0721@2|Bacteria,2G763@200795|Chloroflexi,34DF5@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
CMS3_k127_45905_3	926550.CLDAP_15340	2.802e-62	231.0	COG0500@1|root,COG2226@2|Bacteria,2G780@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_45905_1	926550.CLDAP_15350	2.016e-143	495.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	BiPBP_C,Transgly,Transpeptidase
CMS3_k127_45905_6	1123322.KB904702_gene201	2.087e-43	172.0	COG0745@1|root,COG0745@2|Bacteria,2GJ2N@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	-	-	-	ko:K02483,ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_45905_5	882378.RBRH_02495	1.627e-46	177.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2VIM1@28216|Betaproteobacteria,1K29G@119060|Burkholderiaceae	28216|Betaproteobacteria	KT	response regulator	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_45905_8	438753.AZC_1569	3.965e-33	139.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2TV3A@28211|Alphaproteobacteria,3EYZ3@335928|Xanthobacteraceae	28211|Alphaproteobacteria	T	Response regulator receiver	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_45905_9	159450.NH14_20430	1.161e-25	115.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2VZAM@28216|Betaproteobacteria,1K5X3@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Flavin-binding monooxygenase-like	-	-	1.14.13.84	ko:K14520	ko00363,ko01100,ko01120,map00363,map01100,map01120	-	R06892	RC01644	ko00000,ko00001,ko01000	-	-	-	FMO-like
CMS3_k127_465451_14	479434.Sthe_1443	7.24e-10	63.0	COG1560@1|root,COG1560@2|Bacteria,2G9GW@200795|Chloroflexi,27Z5D@189775|Thermomicrobia	189775|Thermomicrobia	M	Bacterial lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
CMS3_k127_465451_9	1382306.JNIM01000001_gene4122	6.6e-40	160.0	COG0613@1|root,COG0613@2|Bacteria,2G74N@200795|Chloroflexi	200795|Chloroflexi	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
CMS3_k127_465451_7	552811.Dehly_0527	8.624e-93	327.0	COG0438@1|root,COG0438@2|Bacteria,2G61C@200795|Chloroflexi,34CIQ@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Glycosyl transferases group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_465451_10	552811.Dehly_0528	1.253e-38	154.0	COG0558@1|root,COG0558@2|Bacteria,2G6ZT@200795|Chloroflexi,34D5W@301297|Dehalococcoidia	301297|Dehalococcoidia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS3_k127_465451_13	867903.ThesuDRAFT_02320	1.465e-15	90.0	COG3634@1|root,COG3634@2|Bacteria,1V40Z@1239|Firmicutes,24JKA@186801|Clostridia	186801|Clostridia	O	TIGRFAM Glutaredoxin-like domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
CMS3_k127_465451_12	311424.DhcVS_510	7.107e-29	134.0	COG0308@1|root,COG0308@2|Bacteria,2G6SD@200795|Chloroflexi,34D27@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Peptidase MA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2
CMS3_k127_465451_3	926569.ANT_16650	7.058e-113	388.0	COG1186@1|root,COG1186@2|Bacteria,2G5P6@200795|Chloroflexi	200795|Chloroflexi	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CMS3_k127_465451_6	518766.Rmar_0952	1.4e-94	323.0	COG0190@1|root,COG0190@2|Bacteria,4NEJP@976|Bacteroidetes,1FIPD@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
CMS3_k127_465451_11	1382356.JQMP01000003_gene2543	5.958e-34	139.0	COG0736@1|root,COG0736@2|Bacteria,2G73N@200795|Chloroflexi,27YDS@189775|Thermomicrobia	189775|Thermomicrobia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
CMS3_k127_465451_4	552811.Dehly_0249	1.753e-98	342.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2G5Y8@200795|Chloroflexi,34D4S@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
CMS3_k127_465451_8	309801.trd_A0446	4.153e-73	258.0	COG0331@1|root,COG0331@2|Bacteria,2G61W@200795|Chloroflexi,27XR5@189775|Thermomicrobia	189775|Thermomicrobia	I	Acyl transferase domain	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
CMS3_k127_465451_1	562970.Btus_1445	1.167e-134	442.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,2786J@186823|Alicyclobacillaceae	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF_1	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS3_k127_465451_0	1227360.C176_02713	2.361e-140	456.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,26DHA@186818|Planococcaceae	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458,ko:K14660	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iSB619.SA_RS04785	Ketoacyl-synt_C,ketoacyl-synt
CMS3_k127_465451_2	926569.ANT_13120	4.377e-114	402.0	COG0608@1|root,COG0608@2|Bacteria,2G5US@200795|Chloroflexi	200795|Chloroflexi	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
CMS3_k127_465451_5	485916.Dtox_2388	7.204e-95	320.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,2601M@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
CMS3_k127_4776673_10	1121447.JONL01000009_gene2527	4.852e-07	53.0	2DBVP@1|root,2ZBCI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4776673_1	1382306.JNIM01000001_gene1396	3.844e-146	478.0	COG0008@1|root,COG0008@2|Bacteria,2G5WU@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
CMS3_k127_4776673_4	243164.DET1375	8.477e-67	242.0	COG0564@1|root,COG0564@2|Bacteria,2G68N@200795|Chloroflexi,34D96@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS3_k127_4776673_6	1089548.KI783301_gene1156	5.373e-24	108.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,4HIR4@91061|Bacilli,3WETW@539002|Bacillales incertae sedis	91061|Bacilli	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
CMS3_k127_4776673_3	1157490.EL26_00610	8.702e-88	293.0	COG2041@1|root,COG2041@2|Bacteria,1V1P9@1239|Firmicutes,4HFQC@91061|Bacilli,278B0@186823|Alicyclobacillaceae	91061|Bacilli	S	Oxidoreductase molybdopterin binding domain	yuiH	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
CMS3_k127_4776673_8	1294143.H681_17225	8.711e-09	59.0	COG3526@1|root,COG3526@2|Bacteria,1MZ5V@1224|Proteobacteria,1S8S8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	protein conserved in bacteria	-	-	-	ko:K07401	-	-	-	-	ko00000	-	-	-	Rdx
CMS3_k127_4776673_0	266117.Rxyl_1110	5.591e-174	561.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4CPBI@84995|Rubrobacteria	84995|Rubrobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT_4,Malic_M,malic
CMS3_k127_4776673_5	1128421.JAGA01000002_gene101	2.443e-29	126.0	COG0584@1|root,COG0584@2|Bacteria,2NPNS@2323|unclassified Bacteria	2|Bacteria	C	PFAM Glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS3_k127_4776673_9	1397696.KK211189_gene2556	5.856e-08	57.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4776673_7	485913.Krac_2143	8.637e-14	76.0	COG5485@1|root,COG5485@2|Bacteria,2G7DA@200795|Chloroflexi	200795|Chloroflexi	P	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
CMS3_k127_4776673_2	857087.Metme_3517	8.27e-98	329.0	COG0708@1|root,COG0708@2|Bacteria	2|Bacteria	L	double-stranded DNA 3'-5' exodeoxyribonuclease activity	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
CMS3_k127_4776871_1	882083.SacmaDRAFT_2041	1.061e-58	220.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,4EAD8@85010|Pseudonocardiales	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_4776871_9	568076.XP_007819291.1	0.0003381	48.0	KOG4498@1|root,KOG4498@2759|Eukaryota,39UNE@33154|Opisthokonta,3NYQS@4751|Fungi,3QNUG@4890|Ascomycota,211AM@147550|Sordariomycetes,3TE2S@5125|Hypocreales,3G1TV@34397|Clavicipitaceae	4751|Fungi	S	AhpC/TSA antioxidant enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA_2
CMS3_k127_4776871_0	392499.Swit_4328	3.739e-60	219.0	COG4221@1|root,COG4221@2|Bacteria,1QZVX@1224|Proteobacteria	1224|Proteobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
CMS3_k127_4776871_2	324602.Caur_1464	1.106e-45	191.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2GADX@200795|Chloroflexi,375PB@32061|Chloroflexia	32061|Chloroflexia	K	PFAM transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD
CMS3_k127_4776871_6	639283.Snov_1714	9.084e-30	122.0	COG2329@1|root,COG2329@2|Bacteria,1MZKW@1224|Proteobacteria,2UC1E@28211|Alphaproteobacteria,3EZXT@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	MA20_03580	-	-	-	-	-	-	-	-	-	-	-	ABM
CMS3_k127_4776871_7	1463853.JOHW01000002_gene5717	1.288e-16	90.0	COG0596@1|root,COG0596@2|Bacteria,2I9EM@201174|Actinobacteria	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_4776871_5	1370125.AUWT01000020_gene4686	3.176e-33	144.0	COG3173@1|root,COG3173@2|Bacteria,2I8YI@201174|Actinobacteria,232BS@1762|Mycobacteriaceae	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase
CMS3_k127_4776871_4	1380390.JIAT01000011_gene2847	2.896e-40	158.0	COG1309@1|root,COG1309@2|Bacteria,2GNR9@201174|Actinobacteria,4CQDU@84995|Rubrobacteria	84995|Rubrobacteria	K	regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_4776871_3	247633.GP2143_17211	8.081e-44	163.0	COG0346@1|root,COG0346@2|Bacteria,1Q6YP@1224|Proteobacteria,1SHXX@1236|Gammaproteobacteria,1JBPZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_4776871_8	1394178.AWOO02000010_gene4222	1.489e-09	63.0	COG4430@1|root,COG4430@2|Bacteria,2IN25@201174|Actinobacteria,4EPAK@85012|Streptosporangiales	201174|Actinobacteria	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,OmdA
CMS3_k127_4783060_0	479434.Sthe_0322	2.07e-100	340.0	COG0012@1|root,COG0012@2|Bacteria,2G5UY@200795|Chloroflexi,27XGT@189775|Thermomicrobia	189775|Thermomicrobia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
CMS3_k127_4783060_1	522772.Dacet_0129	3.389e-45	175.0	COG1975@1|root,COG1975@2|Bacteria,2GGIC@200930|Deferribacteres	200930|Deferribacteres	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
CMS3_k127_4783060_3	926550.CLDAP_39560	4.037e-21	96.0	COG1975@1|root,COG1975@2|Bacteria	2|Bacteria	O	molybdopterin cofactor binding	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
CMS3_k127_4783060_5	1267211.KI669560_gene1614	7.97e-05	55.0	COG1506@1|root,COG3291@1|root,COG3391@1|root,COG1506@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	wapA	-	3.1.1.102	ko:K06978,ko:K13730,ko:K21105	ko05100,map05100	-	R11541	RC00020,RC00041	ko00000,ko00001,ko01000	-	-	-	AhpC-TSA,NHL,Thioredoxin_8
CMS3_k127_4783060_4	1382356.JQMP01000003_gene2510	3.203e-08	61.0	COG1826@1|root,COG1826@2|Bacteria,2GAXB@200795|Chloroflexi,27YQN@189775|Thermomicrobia	189775|Thermomicrobia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
CMS3_k127_4783060_2	304371.MCP_2958	1.959e-21	106.0	COG1011@1|root,arCOG02291@2157|Archaea	2157|Archaea	S	hydrolase (HAD superfamily)	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CMS3_k127_4787388_1	1121271.AUCM01000002_gene3892	1.463e-19	94.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
CMS3_k127_4787388_0	1089546.AQUI01000002_gene2756	2.099e-177	575.0	COG0604@1|root,COG0604@2|Bacteria,2GKFF@201174|Actinobacteria	201174|Actinobacteria	C	reductase	-	-	1.3.1.85	ko:K14446	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09291	RC02481	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_4804724_1	58344.JOEL01000048_gene2108	3.679e-57	206.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 transport system permease component	thiP	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1
CMS3_k127_4804724_0	463191.SSEG_05795	1.531e-69	248.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
CMS3_k127_4814749_33	357808.RoseRS_1203	7.876e-09	67.0	COG0577@1|root,COG0577@2|Bacteria,2G5WX@200795|Chloroflexi	200795|Chloroflexi	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
CMS3_k127_4814749_34	1146883.BLASA_3642	8.611e-05	53.0	COG1215@1|root,COG1215@2|Bacteria,2GKFI@201174|Actinobacteria,4ESRY@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	bcsA	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,PilZ
CMS3_k127_4814749_0	1205680.CAKO01000035_gene318	4.391e-189	604.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria,2JZBX@204441|Rhodospirillales	204441|Rhodospirillales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_4814749_5	266835.14026571	1.504e-119	396.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,43KK9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	2-dehydropantoate 2-reductase	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
CMS3_k127_4814749_27	1713.JOFV01000008_gene3203	3.749e-20	104.0	COG2353@1|root,COG2353@2|Bacteria,2IM4N@201174|Actinobacteria,4F2JQ@85016|Cellulomonadaceae	201174|Actinobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
CMS3_k127_4814749_18	479434.Sthe_2506	2.745e-54	209.0	COG0477@1|root,COG2814@2|Bacteria,2G6D7@200795|Chloroflexi	2|Bacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_4814749_19	1455608.JDTH01000011_gene2312	6.457e-48	184.0	COG0596@1|root,arCOG01648@2157|Archaea,2XVTE@28890|Euryarchaeota,23TCW@183963|Halobacteria	183963|Halobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_4814749_7	1246995.AFR_01600	1.31e-111	368.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4D9RZ@85008|Micromonosporales	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS3_k127_4814749_31	318167.Sfri_3485	1.005e-15	89.0	2E18Y@1|root,32WP8@2|Bacteria,1QFTA@1224|Proteobacteria,1TD3G@1236|Gammaproteobacteria,2QDUC@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4814749_30	266117.Rxyl_0591	3.442e-17	92.0	COG3415@1|root,COG3415@2|Bacteria,2I3JK@201174|Actinobacteria	201174|Actinobacteria	L	Protein of unknown function (DUF3105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3105
CMS3_k127_4814749_22	523841.HFX_1715	4.215e-38	148.0	COG1611@1|root,arCOG02431@2157|Archaea,2XXTK@28890|Euryarchaeota,23W2P@183963|Halobacteria	183963|Halobacteria	K	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS3_k127_4814749_9	1205680.CAKO01000038_gene1646	4.002e-98	330.0	COG0596@1|root,COG0596@2|Bacteria,1Q4C8@1224|Proteobacteria,2TTW5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	MA20_23630	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_4814749_2	479434.Sthe_0743	6.021e-144	479.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2G5Q5@200795|Chloroflexi,27Y10@189775|Thermomicrobia	200795|Chloroflexi	EU	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS3_k127_4814749_11	1121877.JQKF01000003_gene1502	2.365e-64	228.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria,4CN01@84992|Acidimicrobiia	84992|Acidimicrobiia	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
CMS3_k127_4814749_13	867903.ThesuDRAFT_01275	4.476e-63	233.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia,3WD6V@538999|Clostridiales incertae sedis	186801|Clostridia	C	acyl-CoA transferase carnitine dehydratase	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_4814749_25	485913.Krac_5284	6.534e-23	106.0	COG2318@1|root,COG2318@2|Bacteria,2G77R@200795|Chloroflexi	200795|Chloroflexi	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS3_k127_4814749_10	596151.DesfrDRAFT_1279	5.207e-65	239.0	COG3635@1|root,COG3635@2|Bacteria,1R2SD@1224|Proteobacteria,42NR6@68525|delta/epsilon subdivisions,2WJZY@28221|Deltaproteobacteria,2M9T2@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	TIGRFAM phosphonopyruvate decarboxylase-related protein	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
CMS3_k127_4814749_21	1123371.ATXH01000010_gene705	3.756e-44	170.0	COG1056@1|root,COG1056@2|Bacteria,2GI84@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	cytidyltransferase-related domain	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	-
CMS3_k127_4814749_8	1128421.JAGA01000002_gene1133	1.503e-101	343.0	COG0709@1|root,COG0709@2|Bacteria,2NNUD@2323|unclassified Bacteria	2|Bacteria	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C,Pyr_redox_2
CMS3_k127_4814749_17	525368.HMPREF0591_0025	2.456e-57	214.0	COG0425@1|root,COG0425@2|Bacteria,2I4E3@201174|Actinobacteria,23B3Y@1762|Mycobacteriaceae	201174|Actinobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4814749_20	869210.Marky_2229	5.715e-45	175.0	COG0697@1|root,COG0697@2|Bacteria,1WKUM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4814749_1	1038866.KB902791_gene3357	2.185e-166	537.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2TUNK@28211|Alphaproteobacteria,3JSHP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
CMS3_k127_4814749_12	1123242.JH636436_gene718	1.904e-63	226.0	COG0566@1|root,COG0566@2|Bacteria,2J2FS@203682|Planctomycetes	203682|Planctomycetes	J	SpoU rRNA Methylase family	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
CMS3_k127_4814749_3	485913.Krac_11734	3.333e-131	438.0	COG0488@1|root,COG0488@2|Bacteria	2|Bacteria	L	(ABC) transporter	yjjK	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
CMS3_k127_4814749_26	1380390.JIAT01000010_gene4861	3.693e-21	105.0	COG1970@1|root,COG1970@2|Bacteria,2IQDN@201174|Actinobacteria,4CQN1@84995|Rubrobacteria	84995|Rubrobacteria	M	Large-conductance mechanosensitive channel, MscL	-	-	-	-	-	-	-	-	-	-	-	-	MscL
CMS3_k127_4814749_28	1121448.DGI_2677	1.616e-19	94.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WRBN@28221|Deltaproteobacteria,2MBT4@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS3_k127_4814749_6	525904.Tter_1163	4.589e-112	381.0	COG1032@1|root,COG1032@2|Bacteria,2NQJQ@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS3_k127_4814749_24	1203606.HMPREF1526_00448	3.262e-33	138.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,36F03@31979|Clostridiaceae	186801|Clostridia	T	Phosphatase	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
CMS3_k127_4814749_16	1445613.JALM01000003_gene5062	1.611e-57	224.0	COG1073@1|root,COG1073@2|Bacteria,2GMK3@201174|Actinobacteria,4E10C@85010|Pseudonocardiales	201174|Actinobacteria	S	Prolyl oligopeptidase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_4,Hydrolase_4,Peptidase_S9
CMS3_k127_4814749_23	1144275.COCOR_05742	2.069e-33	138.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,42TZY@68525|delta/epsilon subdivisions,2WQKV@28221|Deltaproteobacteria,2Z1HI@29|Myxococcales	28221|Deltaproteobacteria	K	Crp-like helix-turn-helix domain	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CMS3_k127_4814749_29	889378.Spiaf_0299	7.465e-19	92.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K09766,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	DUF2225,cNMP_binding
CMS3_k127_4814749_15	1380394.JADL01000001_gene2358	1.795e-61	217.0	COG2128@1|root,COG2128@2|Bacteria,1PNA5@1224|Proteobacteria,2U0KT@28211|Alphaproteobacteria,2JWBA@204441|Rhodospirillales	204441|Rhodospirillales	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_4814749_4	1206737.BAGF01000070_gene4446	1.507e-122	419.0	COG0015@1|root,COG0015@2|Bacteria,2GM71@201174|Actinobacteria,4G5VP@85025|Nocardiaceae	201174|Actinobacteria	F	Adenylosuccinate lyase C-terminus	-	-	4.3.2.2,5.5.1.2	ko:K01756,ko:K01857	ko00230,ko00250,ko00362,ko01100,ko01110,ko01120,ko01130,ko01220,map00230,map00250,map00362,map01100,map01110,map01120,map01130,map01220	M00048,M00049	R01083,R03307,R04559	RC00379,RC00444,RC00445,RC00902	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
CMS3_k127_4814749_32	1172188.KB911820_gene2396	3.464e-09	64.0	2FC45@1|root,34483@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4814749_14	402881.Plav_2623	1.435e-61	219.0	COG2267@1|root,COG2267@2|Bacteria,1PFMC@1224|Proteobacteria,2UG1M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_4819201_1	1123060.JONP01000032_gene1866	1.647e-34	139.0	COG2084@1|root,COG2084@2|Bacteria,1PU4S@1224|Proteobacteria,2TT0X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
CMS3_k127_4819201_0	649831.L083_3115	5.849e-71	255.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4DAH5@85008|Micromonosporales	201174|Actinobacteria	C	cytochrome P450	-	-	1.14.14.1	ko:K00493,ko:K21257	ko00071,ko00380,ko00627,ko01059,ko01120,ko01130,map00071,map00380,map00627,map01059,map01120,map01130	M00833,M00834	R03629,R04121,R05259,R11415	RC00046,RC00236,RC01311	ko00000,ko00001,ko00002,ko01000	-	-	-	p450
CMS3_k127_4819201_3	485913.Krac_8820	2.871e-22	102.0	COG2146@1|root,COG2146@2|Bacteria,2G7AG@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Rieske 2Fe-2S domain protein	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
CMS3_k127_4819201_2	1464048.JNZS01000007_gene4600	1.553e-31	130.0	COG0748@1|root,COG0748@2|Bacteria,2I2TX@201174|Actinobacteria	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red,Hemerythrin
CMS3_k127_4821917_0	1313172.YM304_07200	1.361e-22	114.0	COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,2I8W5@201174|Actinobacteria	201174|Actinobacteria	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
CMS3_k127_4821917_1	2002.JOEQ01000031_gene1635	1.34e-11	78.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2GJAR@201174|Actinobacteria,4EHMH@85012|Streptosporangiales	201174|Actinobacteria	KT	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
CMS3_k127_4835236_13	469383.Cwoe_4202	3.002e-05	48.0	COG0526@1|root,COG0526@2|Bacteria,2HDQJ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4835236_11	485913.Krac_9334	6.921e-27	121.0	COG0637@1|root,COG0637@2|Bacteria	2|Bacteria	S	phosphonoacetaldehyde hydrolase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
CMS3_k127_4835236_4	479434.Sthe_3126	1.28e-109	379.0	COG0025@1|root,COG0569@1|root,COG0025@2|Bacteria,COG0569@2|Bacteria,2G6J8@200795|Chloroflexi,27XTU@189775|Thermomicrobia	2|Bacteria	P	TrkA-C domain	nhaP	-	-	-	-	-	-	-	-	-	-	iJN678.sll0556	Na_H_Exchanger,TrkA_N
CMS3_k127_4835236_1	313596.RB2501_15644	1.959e-152	497.0	COG0612@1|root,COG0612@2|Bacteria,4NE0K@976|Bacteroidetes,1HZQH@117743|Flavobacteriia	976|Bacteroidetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_4835236_5	1161401.ASJA01000014_gene1059	1.908e-100	342.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2TRMX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase M16	MA20_05660	-	-	ko:K07263,ko:K07623	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_4835236_7	446471.Xcel_2528	4.694e-79	279.0	COG0477@1|root,COG2814@2|Bacteria,2H0CW@201174|Actinobacteria,4F5ZJ@85017|Promicromonosporaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_4835236_2	1449126.JQKL01000004_gene620	6.922e-131	436.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,2689E@186813|unclassified Clostridiales	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
CMS3_k127_4835236_10	1122247.C731_1921	1.723e-43	172.0	COG3178@1|root,COG3178@2|Bacteria,2GN8T@201174|Actinobacteria,23F8B@1762|Mycobacteriaceae	201174|Actinobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	EcKinase
CMS3_k127_4835236_6	375286.mma_2347	7.993e-82	287.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,476TX@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	CoA-transferase family III	-	-	2.8.3.16,2.8.3.22	ko:K07749,ko:K14471,ko:K14472	ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200	M00376	R00406,R03154	RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
CMS3_k127_4835236_12	1122611.KB903963_gene4702	8.382e-27	127.0	COG0491@1|root,COG0491@2|Bacteria,2H8JM@201174|Actinobacteria,4EJRF@85012|Streptosporangiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_4835236_0	1248760.ANFZ01000002_gene2983	3.492e-169	549.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,2K0UH@204457|Sphingomonadales	204457|Sphingomonadales	F	Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
CMS3_k127_4835236_9	1283300.ATXB01000001_gene792	2.465e-56	214.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Membrane-bound serine protease (ClpP class)	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
CMS3_k127_4835236_8	926569.ANT_29010	1.277e-75	267.0	COG0330@1|root,COG0330@2|Bacteria,2G5SB@200795|Chloroflexi	200795|Chloroflexi	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS3_k127_4835236_3	1382306.JNIM01000001_gene3014	3.941e-127	417.0	COG0183@1|root,COG0183@2|Bacteria,2G63J@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_4838515_6	1479238.JQMZ01000001_gene2556	2.243e-12	70.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,43ZK1@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG2366 Protein related to penicillin acylase	quiP	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
CMS3_k127_4838515_7	869210.Marky_0195	1.17e-11	75.0	COG1011@1|root,COG1011@2|Bacteria,1WK4M@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
CMS3_k127_4838515_8	936455.KI421499_gene54	1.155e-08	67.0	2E474@1|root,32Z30@2|Bacteria,1NDQE@1224|Proteobacteria,2VFXZ@28211|Alphaproteobacteria,3K6HD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4838515_1	396014.BF93_11740	1.609e-69	245.0	COG1120@1|root,COG1120@2|Bacteria,2GJ49@201174|Actinobacteria,4FBA6@85020|Dermabacteraceae	201174|Actinobacteria	HP	ATPases associated with a variety of cellular activities	fecE	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS3_k127_4838515_2	1000569.HMPREF1040_0100	1.736e-64	233.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,4H33N@909932|Negativicutes	909932|Negativicutes	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	fhuG	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
CMS3_k127_4838515_5	1009370.ALO_07618	7.349e-19	98.0	COG0614@1|root,COG0614@2|Bacteria,1UIJ9@1239|Firmicutes,4H2DE@909932|Negativicutes	909932|Negativicutes	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
CMS3_k127_4838515_0	880072.Desac_2549	1.751e-77	267.0	COG0500@1|root,COG2226@2|Bacteria,1RDQI@1224|Proteobacteria,42SIB@68525|delta/epsilon subdivisions,2WPCP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_4838515_4	272134.KB731324_gene6059	2.972e-50	190.0	COG1028@1|root,COG1028@2|Bacteria,1G4S8@1117|Cyanobacteria,1HC0U@1150|Oscillatoriales	1117|Cyanobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059,ko:K19550	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572,M00787	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11067,R11671	RC00029,RC00117,RC03342	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_4839012_2	1265313.HRUBRA_01348	2.889e-18	92.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
CMS3_k127_4839012_0	502025.Hoch_0089	1.928e-147	475.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,42T5F@68525|delta/epsilon subdivisions,2WQVP@28221|Deltaproteobacteria,2YU42@29|Myxococcales	28221|Deltaproteobacteria	C	FMN-dependent dehydrogenase	-	-	1.1.3.46	ko:K16422	ko00261,ko01055,ko01130,map00261,map01055,map01130	-	R06633	RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
CMS3_k127_4839012_1	502025.Hoch_3335	6.442e-68	237.0	COG1409@1|root,COG1409@2|Bacteria,1NS3S@1224|Proteobacteria,43AFC@68525|delta/epsilon subdivisions,2WSTQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS3_k127_4846705_0	1463900.JOIX01000035_gene3787	3.569e-121	394.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
CMS3_k127_4846705_1	1961.JOAK01000003_gene1629	2.307e-06	60.0	COG0454@1|root,COG0454@2|Bacteria,2IDJQ@201174|Actinobacteria	201174|Actinobacteria	K	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
CMS3_k127_4851561_0	525904.Tter_1452	1.69e-111	375.0	COG0303@1|root,COG0303@2|Bacteria,2NP4N@2323|unclassified Bacteria	2|Bacteria	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
CMS3_k127_4851561_1	269800.Tfu_0642	1.835e-13	74.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,4EKJP@85012|Streptosporangiales	201174|Actinobacteria	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
CMS3_k127_4859935_5	378806.STAUR_4355	9.808e-27	120.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,42P2Z@68525|delta/epsilon subdivisions,2WNJ6@28221|Deltaproteobacteria,2YU8C@29|Myxococcales	28221|Deltaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
CMS3_k127_4859935_6	926560.KE387028_gene210	1.193e-23	113.0	COG2380@1|root,COG2380@2|Bacteria,1WJ40@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	COGs COG2380 conserved	-	-	-	ko:K09785	-	-	-	-	ko00000	-	-	-	NurA
CMS3_k127_4859935_0	356851.JOAN01000008_gene3000	5.791e-164	542.0	COG0433@1|root,COG0433@2|Bacteria,2I0H5@201174|Actinobacteria,4D9TP@85008|Micromonosporales	201174|Actinobacteria	S	COG0433 Predicted ATPase	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	-
CMS3_k127_4859935_3	298655.KI912266_gene2095	6.302e-66	245.0	COG0420@1|root,COG0420@2|Bacteria,2GK9R@201174|Actinobacteria,4EUVY@85013|Frankiales	201174|Actinobacteria	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
CMS3_k127_4859935_2	298653.Franean1_3777	9.472e-74	284.0	COG0419@1|root,COG0419@2|Bacteria,2GKYR@201174|Actinobacteria,4EU22@85013|Frankiales	201174|Actinobacteria	L	P-loop containing region of AAA domain	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
CMS3_k127_4859935_7	1343739.PAP_01510	5.747e-12	72.0	COG1905@1|root,arCOG04890@2157|Archaea,2XYS3@28890|Euryarchaeota,243WU@183968|Thermococci	183968|Thermococci	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS3_k127_4859935_1	671143.DAMO_0854	6.257e-82	291.0	COG1894@1|root,COG1905@1|root,COG3411@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,COG3411@2|Bacteria,2NNM1@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoEF	-	1.12.1.3,1.17.1.9,1.6.5.3	ko:K00122,ko:K00335,ko:K17992	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
CMS3_k127_4859935_4	231434.JQJH01000024_gene2106	4.723e-27	118.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria,3NAJI@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	fdsA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
CMS3_k127_4870525_0	298655.KI912266_gene4194	4.221e-104	344.0	COG2124@1|root,COG2124@2|Bacteria,2GJ3T@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
CMS3_k127_4870525_1	1205680.CAKO01000002_gene2546	6.098e-63	230.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	PFAM amidohydrolase	MA20_19310	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
CMS3_k127_4898713_8	102129.Lepto7375DRAFT_2096	2.614e-78	275.0	COG4292@1|root,COG4292@2|Bacteria,1G40Y@1117|Cyanobacteria,1HA5V@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Bacterial low temperature requirement A protein (LtrA)	-	-	-	-	-	-	-	-	-	-	-	-	LtrA
CMS3_k127_4898713_6	1123389.ATXJ01000016_gene54	7.424e-94	318.0	COG0416@1|root,COG0416@2|Bacteria,1WJ6C@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
CMS3_k127_4898713_28	765420.OSCT_1039	5.369e-30	129.0	COG0500@1|root,COG2226@2|Bacteria,2G6N8@200795|Chloroflexi,375GC@32061|Chloroflexia	32061|Chloroflexia	Q	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_4898713_16	102129.Lepto7375DRAFT_2915	6.455e-53	193.0	COG0503@1|root,COG0503@2|Bacteria,1G508@1117|Cyanobacteria,1HAKH@1150|Oscillatoriales	1117|Cyanobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
CMS3_k127_4898713_4	479434.Sthe_1120	2.597e-95	323.0	COG0182@1|root,COG0182@2|Bacteria,2G5Z3@200795|Chloroflexi,27XYC@189775|Thermomicrobia	189775|Thermomicrobia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
CMS3_k127_4898713_7	479434.Sthe_1161	2.754e-90	307.0	COG0005@1|root,COG0005@2|Bacteria,2G5JP@200795|Chloroflexi,27Y3U@189775|Thermomicrobia	189775|Thermomicrobia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
CMS3_k127_4898713_34	356851.JOAN01000035_gene1952	3.91e-14	83.0	COG0454@1|root,COG0456@2|Bacteria,2I61W@201174|Actinobacteria,4DMQX@85008|Micromonosporales	201174|Actinobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	FR47
CMS3_k127_4898713_0	926569.ANT_16170	1.445e-185	589.0	COG0499@1|root,COG0499@2|Bacteria,2G5X8@200795|Chloroflexi	200795|Chloroflexi	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
CMS3_k127_4898713_1	1128421.JAGA01000002_gene898	7.187e-174	554.0	COG0192@1|root,COG0192@2|Bacteria,2NNYF@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.metX	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
CMS3_k127_4898713_10	858619.CVAR_2182	9.292e-72	255.0	COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,22KFH@1653|Corynebacteriaceae	201174|Actinobacteria	JM	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits	manC	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
CMS3_k127_4898713_2	1128421.JAGA01000004_gene2629	3.007e-149	488.0	COG1109@1|root,COG1109@2|Bacteria,2NNTH@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	pgm	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS3_k127_4898713_12	552811.Dehly_1064	3.148e-64	238.0	COG2222@1|root,COG2222@2|Bacteria,2G8HU@200795|Chloroflexi,34D2X@301297|Dehalococcoidia	301297|Dehalococcoidia	G	Bacterial phospho-glucose isomerase C-terminal SIS domain	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	bact-PGI_C
CMS3_k127_4898713_25	935948.KE386495_gene1477	2.478e-38	147.0	COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,24H94@186801|Clostridia,42G8M@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
CMS3_k127_4898713_21	373903.Hore_02460	3.576e-47	181.0	COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia,3WAPJ@53433|Halanaerobiales	186801|Clostridia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
CMS3_k127_4898713_20	765420.OSCT_0173	1.284e-48	184.0	COG0101@1|root,COG0101@2|Bacteria,2G6PE@200795|Chloroflexi,375JX@32061|Chloroflexia	32061|Chloroflexia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
CMS3_k127_4898713_24	935948.KE386495_gene1483	2.07e-39	149.0	COG0203@1|root,COG0203@2|Bacteria,1V6JQ@1239|Firmicutes,24J9T@186801|Clostridia,42GJW@68295|Thermoanaerobacterales	186801|Clostridia	J	ribosomal protein l17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
CMS3_k127_4898713_5	485913.Krac_12501	3.317e-95	324.0	COG0202@1|root,COG0202@2|Bacteria,2G5M9@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
CMS3_k127_4898713_15	1089553.Tph_c25580	3.74e-55	201.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,42ENH@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
CMS3_k127_4898713_19	383372.Rcas_4001	8.879e-50	179.0	COG0100@1|root,COG0100@2|Bacteria,2G6HG@200795|Chloroflexi,375IQ@32061|Chloroflexia	32061|Chloroflexia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
CMS3_k127_4898713_22	1120972.AUMH01000017_gene741	4.291e-46	169.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,4HGX6@91061|Bacilli,278EH@186823|Alicyclobacillaceae	91061|Bacilli	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
CMS3_k127_4898713_35	742742.HMPREF9452_01443	4.588e-10	66.0	COG0257@1|root,COG0257@2|Bacteria,2GWMH@201174|Actinobacteria,4CWQV@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
CMS3_k127_4898713_29	357808.RoseRS_1163	2.829e-28	117.0	COG0361@1|root,COG0361@2|Bacteria,2G70W@200795|Chloroflexi,375UY@32061|Chloroflexia	32061|Chloroflexia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
CMS3_k127_4898713_9	1120973.AQXL01000112_gene1094	1.256e-75	264.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,4H9S9@91061|Bacilli,277XD@186823|Alicyclobacillaceae	91061|Bacilli	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
CMS3_k127_4898713_13	439292.Bsel_0135	3.85e-63	241.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,4HA89@91061|Bacilli,26NQF@186821|Sporolactobacillaceae	91061|Bacilli	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0003674,GO:0003824,GO:0004017,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
CMS3_k127_4898713_3	552811.Dehly_1077	3.424e-148	481.0	COG0201@1|root,COG0201@2|Bacteria,2G5X4@200795|Chloroflexi,34CNS@301297|Dehalococcoidia	301297|Dehalococcoidia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
CMS3_k127_4898713_26	1384484.AEQU_1464	1.553e-33	136.0	COG0200@1|root,COG0200@2|Bacteria,2II6M@201174|Actinobacteria,4CVMS@84998|Coriobacteriia	84998|Coriobacteriia	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
CMS3_k127_4898713_32	485913.Krac_12510	9.948e-21	92.0	COG1841@1|root,COG1841@2|Bacteria,2G7E7@200795|Chloroflexi	200795|Chloroflexi	J	Ribosomal protein L30	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
CMS3_k127_4898713_17	644282.Deba_2921	1.692e-51	189.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
CMS3_k127_4898713_27	1246445.ANAY01000011_gene1008	1.005e-30	130.0	COG0256@1|root,COG0256@2|Bacteria,2IKTX@201174|Actinobacteria,4EJ8X@85012|Streptosporangiales	201174|Actinobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0008150,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
CMS3_k127_4898713_14	479434.Sthe_1051	3.444e-61	216.0	COG0097@1|root,COG0097@2|Bacteria,2G6HZ@200795|Chloroflexi,27Y65@189775|Thermomicrobia	189775|Thermomicrobia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
CMS3_k127_4898713_23	2325.TKV_c20430	4.232e-41	159.0	COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,24HCP@186801|Clostridia,42G9H@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
CMS3_k127_4898713_31	161156.JQKW01000006_gene1046	1.271e-22	99.0	COG0199@1|root,COG0199@2|Bacteria,2GI3J@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
CMS3_k127_4898713_11	309801.trd_0972	5.557e-66	237.0	COG0094@1|root,COG0094@2|Bacteria,2G6C6@200795|Chloroflexi,27XMS@189775|Thermomicrobia	189775|Thermomicrobia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
CMS3_k127_4898713_30	381764.Fnod_1127	2.846e-28	122.0	COG0198@1|root,COG0198@2|Bacteria,2GD31@200918|Thermotogae	200918|Thermotogae	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
CMS3_k127_4898713_18	479434.Sthe_1046	4.47e-50	188.0	COG0093@1|root,COG0093@2|Bacteria,2G6MZ@200795|Chloroflexi,27YG0@189775|Thermomicrobia	189775|Thermomicrobia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
CMS3_k127_4898713_33	637390.AFOH01000069_gene2950	2.261e-19	93.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,2ND2H@225057|Acidithiobacillales	225057|Acidithiobacillales	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
CMS3_k127_4918943_0	1510531.JQJJ01000016_gene3187	2.697e-98	331.0	COG2421@1|root,COG2421@2|Bacteria,1N12N@1224|Proteobacteria,2TV7V@28211|Alphaproteobacteria,3JZ9I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Acetamidase/Formamidase family	-	-	3.5.1.49	ko:K01455	ko00460,ko00630,ko00910,ko01200,map00460,map00630,map00910,map01200	-	R00524	RC02432,RC02810	ko00000,ko00001,ko01000	-	-	-	FmdA_AmdA
CMS3_k127_4993553_1	661478.OP10G_2097	1.745e-13	75.0	COG0316@1|root,COG0316@2|Bacteria	2|Bacteria	S	protein maturation	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
CMS3_k127_4993553_0	290397.Adeh_2440	1.659e-109	368.0	COG0151@1|root,COG0151@2|Bacteria,1NA76@1224|Proteobacteria,43CA7@68525|delta/epsilon subdivisions,2X7KS@28221|Deltaproteobacteria,2Z204@29|Myxococcales	28221|Deltaproteobacteria	F	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
CMS3_k127_5022606_8	936596.HMPREF1495_1356	3.518e-09	65.0	COG0071@1|root,COG0071@2|Bacteria,1VG0E@1239|Firmicutes,24MRZ@186801|Clostridia,1HVS9@1164882|Lachnoanaerobaculum	186801|Clostridia	O	Hsp20/alpha crystallin family	hsp18	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS3_k127_5022606_1	552811.Dehly_1430	6.865e-84	291.0	COG0484@1|root,COG0484@2|Bacteria,2G657@200795|Chloroflexi,34CZG@301297|Dehalococcoidia	301297|Dehalococcoidia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
CMS3_k127_5022606_6	749222.Nitsa_0724	1.222e-26	113.0	COG0789@1|root,COG0789@2|Bacteria,1N948@1224|Proteobacteria,42SGY@68525|delta/epsilon subdivisions,2YPH4@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	K	Transcriptional regulator	hspR	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
CMS3_k127_5022606_0	243164.DET1413	3.41e-304	953.0	COG0542@1|root,COG0542@2|Bacteria,2G62D@200795|Chloroflexi,34CVH@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Belongs to the ClpA ClpB family	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
CMS3_k127_5022606_2	754436.JCM19237_761	4.438e-61	222.0	2AX7Y@1|root,31P6R@2|Bacteria,1QKW7@1224|Proteobacteria,1TJ1U@1236|Gammaproteobacteria,1Y0BC@135623|Vibrionales	135623|Vibrionales	S	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2
CMS3_k127_5022606_7	1382306.JNIM01000001_gene294	5.372e-11	66.0	29684@1|root,2ZTI4@2|Bacteria,2G9NR@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5022606_3	195250.CM001776_gene3771	1.294e-55	202.0	COG0730@1|root,COG0730@2|Bacteria,1GPKA@1117|Cyanobacteria,1H3F4@1129|Synechococcus	1117|Cyanobacteria	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
CMS3_k127_5022606_5	1230341.MJ3_09056	3.43e-28	125.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,4HIKU@91061|Bacilli	91061|Bacilli	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
CMS3_k127_5022606_4	1033743.CAES01000094_gene2768	5.575e-30	132.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,26QDE@186822|Paenibacillaceae	91061|Bacilli	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_2,PUCC,Sugar_tr
CMS3_k127_5035559_2	1318628.MARLIPOL_08104	6.419e-15	74.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,464PA@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	COG0332 3-oxoacyl- acyl-carrier-protein synthase III	fabH	-	2.3.1.207	ko:K16872	-	-	-	-	ko00000,ko01000	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS3_k127_5035559_1	102129.Lepto7375DRAFT_0219	2.388e-73	261.0	COG1680@1|root,COG1680@2|Bacteria,1G7C0@1117|Cyanobacteria,1HD9W@1150|Oscillatoriales	1117|Cyanobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
CMS3_k127_5035559_0	1408473.JHXO01000008_gene2710	1.725e-99	346.0	COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,2FN74@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF4968,Gal_mutarotas_2,Glyco_hydro_31
CMS3_k127_5038082_2	530564.Psta_2936	1.217e-107	351.0	COG1290@1|root,COG1290@2|Bacteria,2IX3Q@203682|Planctomycetes	203682|Planctomycetes	C	Domain of unknown function (DUF4405)	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B
CMS3_k127_5038082_6	292459.STH3147	5.918e-35	146.0	COG1290@1|root,COG1290@2|Bacteria,1USWS@1239|Firmicutes,2501X@186801|Clostridia	186801|Clostridia	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
CMS3_k127_5038082_9	867903.ThesuDRAFT_02244	1.927e-26	117.0	COG0723@1|root,COG0723@2|Bacteria,1VM4K@1239|Firmicutes,24X5X@186801|Clostridia	186801|Clostridia	C	PFAM Rieske 2Fe-2S domain	-	-	1.10.9.1	ko:K02636	ko00195,ko01100,map00195,map01100	M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
CMS3_k127_5038082_13	926550.CLDAP_20080	0.0001088	54.0	COG2010@1|root,COG2010@2|Bacteria,2G9TS@200795|Chloroflexi	2|Bacteria	C	Cytochrome c	-	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C,Cytochrome_CBB3
CMS3_k127_5038082_12	686340.Metal_2267	7.024e-07	61.0	COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,1SFGZ@1236|Gammaproteobacteria,1XFNP@135618|Methylococcales	135618|Methylococcales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K19344	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
CMS3_k127_5038082_11	1132441.KI519455_gene3450	6.238e-08	55.0	2ECT0@1|root,32RXS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5038082_10	316274.Haur_2659	1.872e-11	71.0	COG0828@1|root,COG0828@2|Bacteria,2G7EY@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
CMS3_k127_5038082_8	500635.MITSMUL_04731	1.674e-30	125.0	COG1610@1|root,COG1610@2|Bacteria,1V6F2@1239|Firmicutes,4H4MK@909932|Negativicutes	909932|Negativicutes	S	YqeY-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
CMS3_k127_5038082_3	1128421.JAGA01000002_gene1506	1.042e-91	330.0	COG1480@1|root,COG1480@2|Bacteria,2NP1K@2323|unclassified Bacteria	2|Bacteria	S	7TM receptor with intracellular HD hydrolase	yqfF	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
CMS3_k127_5038082_4	1121428.DESHY_70012___1	3.217e-78	267.0	COG0047@1|root,COG0047@2|Bacteria,1TP1B@1239|Firmicutes,24A2E@186801|Clostridia,260V1@186807|Peptococcaceae	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
CMS3_k127_5038082_1	2074.JNYD01000007_gene2073	8.98e-129	431.0	COG0069@1|root,COG4638@1|root,COG0069@2|Bacteria,COG4638@2|Bacteria,2GME2@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_9,Glu_syn_central,Glu_synthase,Rieske
CMS3_k127_5038082_0	1449126.JQKL01000015_gene2926	4.833e-232	743.0	COG0046@1|root,COG0046@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,267K1@186813|unclassified Clostridiales	186801|Clostridia	F	AIR synthase related protein, C-terminal domain	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
CMS3_k127_5038082_14	762948.HMPREF0733_12123	0.0002845	49.0	COG1051@1|root,COG1051@2|Bacteria,2GX87@201174|Actinobacteria	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS3_k127_5038082_7	525904.Tter_1814	1.285e-32	137.0	COG0359@1|root,COG0359@2|Bacteria,2NPX4@2323|unclassified Bacteria	2|Bacteria	J	Binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
CMS3_k127_5038082_5	525904.Tter_1815	3.53e-38	153.0	COG0305@1|root,COG0305@2|Bacteria,2NNKG@2323|unclassified Bacteria	2|Bacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
CMS3_k127_5048678_1	1343740.M271_45150	7.583e-32	126.0	COG1359@1|root,COG1359@2|Bacteria,2I72N@201174|Actinobacteria	201174|Actinobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
CMS3_k127_5048678_2	204669.Acid345_2176	2.531e-20	93.0	COG4274@1|root,COG4274@2|Bacteria,3Y8NH@57723|Acidobacteria,2JNFZ@204432|Acidobacteriia	204432|Acidobacteriia	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
CMS3_k127_5048678_0	395019.Bmul_4142	6.145e-71	248.0	COG1573@1|root,COG1573@2|Bacteria,1R9XV@1224|Proteobacteria,2VQ52@28216|Betaproteobacteria,1K1WB@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM Uracil-DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF488,UDG
CMS3_k127_5048678_3	1265845.PWEIH_16918	6.939e-11	71.0	COG3708@1|root,COG3708@2|Bacteria,1VJT1@1239|Firmicutes,4HREN@91061|Bacilli	91061|Bacilli	K	Putative zinc ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Zn_ribbon_2
CMS3_k127_5113958_0	2074.JNYD01000015_gene4604	2.31e-78	278.0	COG3848@1|root,COG3848@2|Bacteria,2H2J1@201174|Actinobacteria	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
CMS3_k127_5113958_6	795359.TOPB45_1086	2.869e-31	127.0	COG2250@1|root,COG2250@2|Bacteria,2GIPR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
CMS3_k127_5113958_9	1089553.Tph_c03020	6.181e-06	57.0	COG1708@1|root,COG2020@1|root,COG1708@2|Bacteria,COG2020@2|Bacteria,1VCPX@1239|Firmicutes,24PE0@186801|Clostridia,42H2N@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM DNA polymerase beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CMS3_k127_5113958_4	768704.Desmer_1347	2.246e-37	157.0	COG2247@1|root,COG3391@1|root,COG2247@2|Bacteria,COG3391@2|Bacteria,1V2E4@1239|Firmicutes,24TKC@186801|Clostridia	186801|Clostridia	M	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
CMS3_k127_5113958_1	1122915.AUGY01000013_gene2918	1.495e-77	273.0	COG4102@1|root,COG4102@2|Bacteria,1VDF3@1239|Firmicutes,4HV1I@91061|Bacilli,26W8X@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_5113958_2	1303518.CCALI_02907	9.99e-70	256.0	COG5267@1|root,COG5267@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
CMS3_k127_5113958_3	1120797.KB908261_gene144	5.551e-58	220.0	COG3673@1|root,COG3673@2|Bacteria,2ID7N@201174|Actinobacteria,235R3@1762|Mycobacteriaceae	201174|Actinobacteria	S	Uncharacterized alpha/beta hydrolase domain (DUF2235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2235
CMS3_k127_5113958_8	381666.H16_A0147	9.521e-26	117.0	COG2021@1|root,COG2021@2|Bacteria,1QU84@1224|Proteobacteria,2VRYJ@28216|Betaproteobacteria,1K0JE@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM alpha beta hydrolase fold	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
CMS3_k127_5113958_7	557599.MKAN_28865	2.917e-29	137.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,2349V@1762|Mycobacteriaceae	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
CMS3_k127_5113958_5	1268303.RHODMAR_2194	4.963e-34	138.0	COG2114@1|root,COG2114@2|Bacteria,2I8W5@201174|Actinobacteria,4G938@85025|Nocardiaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
CMS3_k127_5123135_4	1396141.BATP01000032_gene4356	2.075e-97	335.0	COG0514@1|root,COG0514@2|Bacteria,46S7V@74201|Verrucomicrobia,2IWN0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	RQC	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
CMS3_k127_5123135_2	1229780.BN381_80111	3.507e-118	419.0	COG4907@1|root,COG4907@2|Bacteria,2GNW7@201174|Actinobacteria,3UXG9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
CMS3_k127_5123135_7	1229780.BN381_50097	1.278e-55	201.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria,3UWSB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
CMS3_k127_5123135_12	491915.Aflv_2851	2.19e-32	138.0	COG0668@1|root,COG0668@2|Bacteria,1TR9Z@1239|Firmicutes,4HCB8@91061|Bacilli,21WC2@150247|Anoxybacillus	91061|Bacilli	M	Mechanosensitive ion channel	ykuT	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
CMS3_k127_5123135_5	1288826.MSNKSG1_14177	4.729e-93	320.0	COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,1RRTZ@1236|Gammaproteobacteria,464S0@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	CorA-like Mg2+ transporter protein	zntB	GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662	-	ko:K16074	-	-	-	-	ko00000,ko02000	1.A.35.4	-	-	CorA
CMS3_k127_5123135_3	351607.Acel_1530	7.296e-112	390.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4ESAG@85013|Frankiales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994,ko:K20470	-	-	-	-	ko00000,ko02000	2.A.6.5.6	-	-	MMPL
CMS3_k127_5123135_1	324602.Caur_1931	4.392e-126	415.0	COG0304@1|root,COG0304@2|Bacteria,2G7RK@200795|Chloroflexi,376IR@32061|Chloroflexia	32061|Chloroflexia	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS3_k127_5123135_15	204669.Acid345_4730	3.198e-07	63.0	COG0664@1|root,COG4420@1|root,COG0664@2|Bacteria,COG4420@2|Bacteria,3Y2H3@57723|Acidobacteria,2JHTN@204432|Acidobacteriia	2|Bacteria	T	cyclic nucleotide-binding	yejC	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	DUF1003
CMS3_k127_5123135_13	1121121.KB894290_gene1855	5.513e-30	137.0	COG1752@1|root,COG1752@2|Bacteria,1UUVB@1239|Firmicutes,4HDFQ@91061|Bacilli,26WHE@186822|Paenibacillaceae	91061|Bacilli	S	Patatin-like phospholipase	ylbK	GO:0003674,GO:0003824,GO:0016787	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
CMS3_k127_5123135_10	211165.AJLN01000143_gene1409	6.314e-37	154.0	COG2843@1|root,COG2843@2|Bacteria,1G20Q@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
CMS3_k127_5123135_9	2074.JNYD01000022_gene1462	3.579e-45	177.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_5123135_0	986075.CathTA2_1034	1.087e-227	719.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,4H9QB@91061|Bacilli	91061|Bacilli	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
CMS3_k127_5123135_16	485913.Krac_2206	0.0001758	50.0	COG4283@1|root,COG4283@2|Bacteria,2G9AR@200795|Chloroflexi	2|Bacteria	S	Protein of unknown function (DUF1706)	M1-431	-	-	-	-	-	-	-	-	-	-	-	DUF1706
CMS3_k127_5123135_11	469383.Cwoe_5865	1.792e-34	143.0	COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,4CQ97@84995|Rubrobacteria	84995|Rubrobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
CMS3_k127_5123135_8	525904.Tter_1673	6.611e-53	189.0	COG2185@1|root,COG2185@2|Bacteria,2NPGA@2323|unclassified Bacteria	2|Bacteria	I	Cobalamin B12-binding	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
CMS3_k127_5123135_6	383372.Rcas_2999	3.296e-77	272.0	COG1703@1|root,COG1703@2|Bacteria,2G670@200795|Chloroflexi,3751X@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
CMS3_k127_5123135_14	926569.ANT_22530	4.782e-11	63.0	COG5011@1|root,COG5011@2|Bacteria,2G71I@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized protein conserved in bacteria (DUF2344)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
CMS3_k127_5132271_2	525904.Tter_1430	1.653e-61	231.0	COG0544@1|root,COG0544@2|Bacteria,2NPBN@2323|unclassified Bacteria	2|Bacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
CMS3_k127_5132271_1	255470.cbdbA666	7.467e-83	281.0	COG0740@1|root,COG0740@2|Bacteria,2G6BN@200795|Chloroflexi,34D07@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
CMS3_k127_5132271_0	485913.Krac_0006	7.192e-130	419.0	COG1219@1|root,COG1219@2|Bacteria,2G661@200795|Chloroflexi	200795|Chloroflexi	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
CMS3_k127_5167337_1	1347369.CCAD010000043_gene993	1.376e-11	66.0	COG4799@1|root,COG4799@2|Bacteria,1VTDE@1239|Firmicutes,4HU50@91061|Bacilli,1ZFG8@1386|Bacillus	91061|Bacilli	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
CMS3_k127_5167337_0	1347369.CCAD010000043_gene993	1.57e-163	531.0	COG4799@1|root,COG4799@2|Bacteria,1VTDE@1239|Firmicutes,4HU50@91061|Bacilli,1ZFG8@1386|Bacillus	91061|Bacilli	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
CMS3_k127_5167337_2	1354722.JQLS01000008_gene2101	0.0007844	42.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TTM5@28211|Alphaproteobacteria,46P7K@74030|Roseovarius	28211|Alphaproteobacteria	C	Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate	frc	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_5171744_0	357808.RoseRS_2190	1.114e-135	465.0	COG2373@1|root,COG2373@2|Bacteria,2G5XN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM alpha-2-macroglobulin domain protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1
CMS3_k127_5171744_7	1121013.P873_01410	1.674e-30	125.0	COG2944@1|root,COG2944@2|Bacteria,1N21E@1224|Proteobacteria,1SS0W@1236|Gammaproteobacteria,1X8P3@135614|Xanthomonadales	135614|Xanthomonadales	K	Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
CMS3_k127_5171744_11	338969.Rfer_2227	1.407e-25	125.0	COG0457@1|root,COG1396@1|root,COG3899@1|root,COG0457@2|Bacteria,COG1396@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VPH8@28216|Betaproteobacteria,4AF3Y@80864|Comamonadaceae	28216|Betaproteobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD
CMS3_k127_5171744_17	1449976.KALB_1218	2.435e-05	58.0	COG2197@1|root,COG2197@2|Bacteria,2GNAU@201174|Actinobacteria,4E2KA@85010|Pseudonocardiales	201174|Actinobacteria	K	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_5171744_12	318424.EU78_20825	4.705e-22	105.0	COG2114@1|root,COG2114@2|Bacteria,2I8W5@201174|Actinobacteria,234SY@1762|Mycobacteriaceae	201174|Actinobacteria	T	PFAM Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
CMS3_k127_5171744_4	1206741.BAFX01000017_gene7137	5.053e-85	301.0	COG2346@1|root,COG3369@1|root,COG3592@1|root,COG2346@2|Bacteria,COG3369@2|Bacteria,COG3592@2|Bacteria,2GMG5@201174|Actinobacteria,4FZD3@85025|Nocardiaceae	201174|Actinobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	ABM,Bac_globin,Fer4_19,zf-CDGSH
CMS3_k127_5171744_14	887898.HMPREF0551_1003	1.038e-16	89.0	COG0664@1|root,COG0664@2|Bacteria,1RE4X@1224|Proteobacteria,2VRYB@28216|Betaproteobacteria,1K34H@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CMS3_k127_5171744_13	266117.Rxyl_2821	2.269e-17	91.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
CMS3_k127_5171744_5	1123276.KB893270_gene4724	8.691e-44	170.0	COG1409@1|root,COG1409@2|Bacteria,4NRDF@976|Bacteroidetes,47VTX@768503|Cytophagia	976|Bacteroidetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	3.1.3.16	ko:K21814	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	Metallophos
CMS3_k127_5171744_15	485913.Krac_0161	2.199e-07	52.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
CMS3_k127_5171744_1	1352941.M877_09000	2.574e-120	415.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria	201174|Actinobacteria	F	Drug exporters of the RND superfamily	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
CMS3_k127_5171744_16	1507.HMPREF0262_00168	2.74e-07	56.0	COG1396@1|root,COG1974@1|root,COG1396@2|Bacteria,COG1974@2|Bacteria,1UHUG@1239|Firmicutes,25E2W@186801|Clostridia	186801|Clostridia	K	Peptidase S24-like	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Peptidase_S24
CMS3_k127_5171744_3	543728.Vapar_3549	2.477e-110	393.0	COG0457@1|root,COG2197@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2197@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VPH8@28216|Betaproteobacteria,4AF3Y@80864|Comamonadaceae	28216|Betaproteobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD
CMS3_k127_5171744_2	1168034.FH5T_19015	7.277e-114	387.0	COG0644@1|root,COG0644@2|Bacteria,4P040@976|Bacteroidetes	976|Bacteroidetes	C	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5171744_10	237368.SCABRO_02138	1.229e-25	112.0	COG0664@1|root,COG0664@2|Bacteria,2J4FD@203682|Planctomycetes	203682|Planctomycetes	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
CMS3_k127_5171744_6	1123242.JH636434_gene3762	8.662e-39	156.0	COG1272@1|root,COG1272@2|Bacteria,2J0X6@203682|Planctomycetes	203682|Planctomycetes	S	Haemolysin-III related	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
CMS3_k127_5171744_9	46234.ANA_C20482	5.351e-27	113.0	COG0724@1|root,COG0724@2|Bacteria,1GDTM@1117|Cyanobacteria,1HP2X@1161|Nostocales	1117|Cyanobacteria	S	RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS3_k127_5171744_8	1040989.AWZU01000023_gene4843	3.375e-29	123.0	COG3631@1|root,COG3631@2|Bacteria	2|Bacteria	S	light absorption	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
CMS3_k127_5206298_3	469383.Cwoe_5531	2.074e-106	356.0	COG0155@1|root,COG0155@2|Bacteria,2GJRN@201174|Actinobacteria,4CQKT@84995|Rubrobacteria	84995|Rubrobacteria	C	Nitrite and sulphite reductase 4Fe-4S domain	-	-	1.7.7.1,1.8.1.2	ko:K00366,ko:K00381	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00858	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
CMS3_k127_5206298_1	1144275.COCOR_04629	2.296e-145	466.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,42NYE@68525|delta/epsilon subdivisions,2WK6Q@28221|Deltaproteobacteria,2YTSR@29|Myxococcales	28221|Deltaproteobacteria	H	Phosphoadenosine phosphosulfate reductase family	-	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
CMS3_k127_5206298_0	134676.ACPL_7782	6.951e-163	525.0	COG2895@1|root,COG2895@2|Bacteria,2GJDX@201174|Actinobacteria,4DAUT@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysC	GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006793,GO:0006796,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:0071944,GO:1902494,GO:1902503,GO:1990234	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
CMS3_k127_5206298_4	864702.OsccyDRAFT_4328	1.275e-104	345.0	COG0175@1|root,COG0175@2|Bacteria,1G1RY@1117|Cyanobacteria,1H7BQ@1150|Oscillatoriales	1117|Cyanobacteria	EH	Reduction of activated sulfate into sulfite	cysH	GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
CMS3_k127_5206298_2	266117.Rxyl_0748	3.452e-114	378.0	COG0667@1|root,COG0667@2|Bacteria,2GJBG@201174|Actinobacteria,4CPGS@84995|Rubrobacteria	84995|Rubrobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS3_k127_5206298_5	42256.RradSPS_2515	4.364e-94	321.0	COG1522@1|root,COG1522@2|Bacteria,2IIXK@201174|Actinobacteria,4CPCF@84995|Rubrobacteria	84995|Rubrobacteria	K	AsnC-type helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
CMS3_k127_5206298_6	926566.Terro_2211	6.3e-51	202.0	COG3253@1|root,COG3253@2|Bacteria,3Y39D@57723|Acidobacteria,2JK6X@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
CMS3_k127_5206298_7	1122614.JHZF01000011_gene2301	2.55e-09	61.0	2DMP1@1|root,32SS8@2|Bacteria,1NC27@1224|Proteobacteria,2VGQD@28211|Alphaproteobacteria,2PFYS@252301|Oceanicola	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3237)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3237
CMS3_k127_523355_1	383372.Rcas_3992	3.47e-19	95.0	COG1011@1|root,COG1011@2|Bacteria,2G73G@200795|Chloroflexi,3760J@32061|Chloroflexia	32061|Chloroflexia	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CMS3_k127_523355_2	1382306.JNIM01000001_gene1044	4.1e-16	83.0	2CJPB@1|root,33JM7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_523355_0	552811.Dehly_0299	7.73e-123	407.0	COG0014@1|root,COG0014@2|Bacteria,2G5TY@200795|Chloroflexi,34CYU@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_5265843_5	1380355.JNIJ01000026_gene1330	5.618e-63	222.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,3JUIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS3_k127_5265843_3	1005994.GTGU_03540	7.166e-67	239.0	COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,1RNBC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	transport	gsiD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K13891	ko02010,map02010	M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.11	-	iECABU_c1320.ECABU_c08730,iECP_1309.ECP_0846,ic_1306.c0917	BPD_transp_1,OppC_N
CMS3_k127_5265843_1	1297865.APJD01000009_gene2849	4.193e-84	291.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,3JUIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS3_k127_5265843_4	1005994.GTGU_03540	9.441e-66	235.0	COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,1RNBC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	transport	gsiD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K13891	ko02010,map02010	M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.11	-	iECABU_c1320.ECABU_c08730,iECP_1309.ECP_0846,ic_1306.c0917	BPD_transp_1,OppC_N
CMS3_k127_5265843_0	1382356.JQMP01000003_gene1573	1.931e-191	612.0	COG0028@1|root,COG0028@2|Bacteria,2G810@200795|Chloroflexi,27XX3@189775|Thermomicrobia	189775|Thermomicrobia	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_5265843_2	382464.ABSI01000011_gene2491	4.627e-81	282.0	COG0673@1|root,COG0673@2|Bacteria,46TQ2@74201|Verrucomicrobia,2IVP0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_5265843_6	653386.HMPREF0975_02817	4.099e-11	74.0	COG4283@1|root,COG4283@2|Bacteria,2IGS2@201174|Actinobacteria,4D44H@85005|Actinomycetales	201174|Actinobacteria	S	Protein of unknown function (DUF1706)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1706
CMS3_k127_5336582_13	1370125.AUWT01000052_gene4919	3.09e-07	55.0	COG2124@1|root,COG2124@2|Bacteria,2HZR8@201174|Actinobacteria,232NY@1762|Mycobacteriaceae	201174|Actinobacteria	Q	cytochrome p450	cyp144A4	-	-	ko:K21200	-	-	-	-	ko00000,ko00199	-	-	-	p450
CMS3_k127_5336582_14	1394178.AWOO02000059_gene607	0.0007563	48.0	COG1141@1|root,COG1141@2|Bacteria,2GR5R@201174|Actinobacteria,4EQXC@85012|Streptosporangiales	201174|Actinobacteria	C	Divergent 4Fe-4S mono-cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13,Fer4_15
CMS3_k127_5336582_8	1048339.KB913029_gene3211	1.465e-51	194.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4ESG7@85013|Frankiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_5336582_6	596153.Alide_3284	4.488e-61	224.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2VQCB@28216|Betaproteobacteria,4AG75@80864|Comamonadaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	ko:K07546	ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220	M00418	R05599	RC01435	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_5336582_7	365528.KB891228_gene277	7.32e-54	196.0	COG0526@1|root,COG0526@2|Bacteria,2HZTZ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_5336582_10	479433.Caci_0867	1.143e-23	105.0	COG0526@1|root,COG0526@2|Bacteria,2HZTZ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_5336582_1	448385.sce3486	1.171e-126	422.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,42N4C@68525|delta/epsilon subdivisions,2WJIH@28221|Deltaproteobacteria,2YZWU@29|Myxococcales	28221|Deltaproteobacteria	E	GMC oxidoreductase	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
CMS3_k127_5336582_3	266940.Krad_1032	8.045e-100	345.0	COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria	201174|Actinobacteria	Q	N-acyl-D-aspartate D-glutamate deacylase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
CMS3_k127_5336582_4	502025.Hoch_6686	2.072e-80	285.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,42N0J@68525|delta/epsilon subdivisions,2WJFX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	HRDC domain protein	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
CMS3_k127_5336582_0	1322246.BN4_12067	3.152e-142	477.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2M88F@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS3_k127_5336582_12	543632.JOJL01000014_gene9192	5.064e-18	94.0	COG0558@1|root,COG0558@2|Bacteria	543632.JOJL01000014_gene9192|-	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5336582_11	1382306.JNIM01000001_gene3810	1.051e-18	95.0	COG1011@1|root,COG1011@2|Bacteria	1382306.JNIM01000001_gene3810|-	S	phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5336582_9	1267535.KB906767_gene4015	4.116e-46	175.0	COG5424@1|root,COG5424@2|Bacteria,3Y718@57723|Acidobacteria,2JKMM@204432|Acidobacteriia	204432|Acidobacteriia	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
CMS3_k127_5336582_2	1157640.AQWO01000005_gene2159	2.458e-103	349.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	lipP	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_5336582_5	706587.Desti_2022	1.747e-75	278.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,42Y9Q@68525|delta/epsilon subdivisions,2WTQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_5341704_4	272563.CD630_33850	0.0001627	48.0	COG4734@1|root,COG4734@2|Bacteria,1TNY7@1239|Firmicutes,249HA@186801|Clostridia,25QZD@186804|Peptostreptococcaceae	186801|Clostridia	S	Antirestriction protein (ArdA)	-	-	-	-	-	-	-	-	-	-	-	-	ArdA
CMS3_k127_5341704_2	1226322.HMPREF1545_03542	6.915e-43	168.0	COG4106@1|root,COG4106@2|Bacteria	2|Bacteria	FG	trans-aconitate 2-methyltransferase activity	cmoA	-	2.1.1.197	ko:K02169,ko:K15256	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Methyltransf_25
CMS3_k127_5341704_0	365528.KB891217_gene1483	6.246e-132	437.0	COG0367@1|root,COG0367@2|Bacteria,2I9UP@201174|Actinobacteria	201174|Actinobacteria	E	Glutamine amidotransferase domain	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS3_k127_5341704_1	460265.Mnod_6992	4.669e-127	423.0	COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,2TTZG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family	dcm	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase,HTH_3,HTH_31
CMS3_k127_5341704_5	395964.KE386496_gene1574	0.0002036	47.0	COG1605@1|root,COG1605@2|Bacteria,1MWTP@1224|Proteobacteria,2TV3Z@28211|Alphaproteobacteria,3N9YA@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Chorismate mutase type II	MA20_20425	-	-	-	-	-	-	-	-	-	-	-	CM_2
CMS3_k127_5341704_3	1121382.JQKG01000001_gene2512	0.0001091	49.0	COG1475@1|root,COG1475@2|Bacteria	2|Bacteria	K	chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
CMS3_k127_5375490_11	1273538.G159_16345	8.296e-27	127.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26ECD@186818|Planococcaceae	91061|Bacilli	E	substrate-binding protein	dppA_1	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_5375490_10	1382306.JNIM01000001_gene780	4.955e-31	132.0	2DN66@1|root,32VSD@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
CMS3_k127_5375490_12	1150864.MILUP08_46134	2.143e-14	80.0	COG3832@1|root,COG3832@2|Bacteria,2IFGN@201174|Actinobacteria,4DENC@85008|Micromonosporales	201174|Actinobacteria	S	Activator of hsp90 atpase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_5375490_5	593907.Celgi_2353	8.905e-88	298.0	COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria,4F0PC@85016|Cellulomonadaceae	201174|Actinobacteria	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
CMS3_k127_5375490_8	345341.KUTG_07033	2.128e-66	239.0	COG2141@1|root,COG2141@2|Bacteria,2GKCU@201174|Actinobacteria,4EEIC@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_5375490_0	525904.Tter_1474	5.086e-221	705.0	COG0667@1|root,COG0673@1|root,COG0667@2|Bacteria,COG0673@2|Bacteria,2NP86@2323|unclassified Bacteria	2|Bacteria	C	Oxidoreductase family, NAD-binding Rossmann fold	strT	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,GFO_IDH_MocA
CMS3_k127_5375490_15	366649.XFF4834R_chr13510	0.0004809	47.0	COG1476@1|root,COG2856@1|root,COG1476@2|Bacteria,COG2856@2|Bacteria,1NEHF@1224|Proteobacteria,1RMJ3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,Peptidase_M78
CMS3_k127_5375490_6	479434.Sthe_0535	8.656e-78	270.0	COG1028@1|root,COG1028@2|Bacteria,2G5KB@200795|Chloroflexi,27XUY@189775|Thermomicrobia	200795|Chloroflexi	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_5375490_9	1214101.BN159_4987	3.259e-54	200.0	COG1024@1|root,COG1024@2|Bacteria,2I2PC@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	echA11	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS3_k127_5375490_7	1121324.CLIT_2c03230	1.776e-71	249.0	COG2998@1|root,COG2998@2|Bacteria,1V9V8@1239|Firmicutes,25H3U@186801|Clostridia	186801|Clostridia	H	Copper amine oxidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1
CMS3_k127_5375490_13	1123024.AUII01000006_gene4641	1.707e-13	76.0	2BKPP@1|root,32F5B@2|Bacteria,2GZGW@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_2
CMS3_k127_5375490_3	1122138.AQUZ01000056_gene6929	3.882e-97	323.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4DPH5@85009|Propionibacteriales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_5375490_4	710687.KI912270_gene4527	8.106e-90	315.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,2I2WW@201174|Actinobacteria,23FHB@1762|Mycobacteriaceae	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_5375490_1	1424334.W822_02615	2.012e-120	409.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2W9AM@28216|Betaproteobacteria,3T71C@506|Alcaligenaceae	28216|Betaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
CMS3_k127_5375490_14	1541959.KQ51_00282	1.396e-11	73.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria	2|Bacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ppsA	-	2.7.9.2,6.5.1.3	ko:K01007,ko:K14415	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PEP-utilizers,PPDK_N
CMS3_k127_5375490_2	891968.Anamo_1264	1.256e-101	342.0	COG1071@1|root,COG1071@2|Bacteria,3TA5N@508458|Synergistetes	508458|Synergistetes	C	E1 component	pdhA	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
CMS3_k127_5422085_8	485913.Krac_8885	3.113e-24	111.0	COG1937@1|root,COG1937@2|Bacteria,2G7H9@200795|Chloroflexi	200795|Chloroflexi	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
CMS3_k127_5422085_0	266117.Rxyl_0133	1.943e-218	707.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CPA7@84995|Rubrobacteria	84995|Rubrobacteria	P	heavy metal translocating P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
CMS3_k127_5422085_2	316274.Haur_2844	3.957e-98	331.0	COG1108@1|root,COG1108@2|Bacteria,2G6GH@200795|Chloroflexi,376AB@32061|Chloroflexia	200795|Chloroflexi	P	ABC-3 protein	-	-	-	ko:K09816,ko:K09819	ko02010,map02010	M00242,M00243	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
CMS3_k127_5422085_3	1048339.KB913029_gene4025	3.429e-76	269.0	COG1121@1|root,COG1121@2|Bacteria,2GN95@201174|Actinobacteria,4ET4X@85013|Frankiales	201174|Actinobacteria	P	pfam abc	-	-	3.6.3.35	ko:K02074,ko:K09820,ko:K11710,ko:K19973	ko02010,map02010	M00243,M00244,M00319,M00792	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.15	-	-	ABC_tran
CMS3_k127_5422085_1	316274.Haur_2846	4.398e-108	367.0	COG0803@1|root,COG0803@2|Bacteria,2G8F6@200795|Chloroflexi,37738@32061|Chloroflexia	200795|Chloroflexi	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K02077,ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
CMS3_k127_5422085_9	33876.JNXY01000019_gene7633	3.871e-19	93.0	COG0735@1|root,COG0735@2|Bacteria,2IFHB@201174|Actinobacteria,4DEKA@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS3_k127_5422085_5	867845.KI911784_gene1619	7.558e-64	238.0	COG0477@1|root,COG0477@2|Bacteria,2G856@200795|Chloroflexi,375QC@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_5422085_6	2074.JNYD01000001_gene6177	2.219e-58	217.0	COG1960@1|root,COG1960@2|Bacteria,2H7DI@201174|Actinobacteria,4DZXM@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_5422085_4	1133849.O3I_017965	7.623e-69	241.0	COG1733@1|root,COG1733@2|Bacteria,2GMK5@201174|Actinobacteria,4FZ9I@85025|Nocardiaceae	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR,SCP2
CMS3_k127_5422085_7	660470.Theba_2651	1.912e-30	135.0	COG0477@1|root,COG2814@2|Bacteria,2GD1X@200918|Thermotogae	200918|Thermotogae	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_54940_5	717605.Theco_0046	1.139e-06	57.0	COG1388@1|root,COG1388@2|Bacteria,1V2ND@1239|Firmicutes,4HGIW@91061|Bacilli,26T28@186822|Paenibacillaceae	91061|Bacilli	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	Gmad2,LysM
CMS3_k127_54940_4	749414.SBI_09815	6.109e-10	71.0	COG2940@1|root,COG2940@2|Bacteria	2|Bacteria	K	SET domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
CMS3_k127_54940_1	401526.TcarDRAFT_0990	0.0	1320.0	COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,4H21V@909932|Negativicutes	909932|Negativicutes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
CMS3_k127_54940_0	479434.Sthe_1030	0.0	1501.0	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi,27Y0B@189775|Thermomicrobia	189775|Thermomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
CMS3_k127_54940_2	1382306.JNIM01000001_gene3513	1.695e-129	426.0	COG0334@1|root,COG0334@2|Bacteria,2G5SR@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_54940_3	1463821.JOGR01000004_gene2351	4.379e-10	64.0	2EH2B@1|root,33AU9@2|Bacteria,2H930@201174|Actinobacteria	201174|Actinobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CMS3_k127_557116_1	479434.Sthe_0736	2.433e-44	170.0	COG4314@1|root,COG4314@2|Bacteria,2G8NV@200795|Chloroflexi,27Z7G@189775|Thermomicrobia	189775|Thermomicrobia	C	lipoprotein involved in nitrous oxide reduction	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_557116_0	518766.Rmar_2012	1.36e-280	877.0	COG4263@1|root,COG4263@2|Bacteria,4NFNE@976|Bacteroidetes,1FIVE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Nitrous oxide reductase	nosZ	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	-
CMS3_k127_557116_2	574966.KB898647_gene2566	1.815e-33	139.0	COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,1SYEA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC,ZnuA
CMS3_k127_5571267_2	479434.Sthe_2506	1.772e-52	207.0	COG0477@1|root,COG2814@2|Bacteria,2G6D7@200795|Chloroflexi	2|Bacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_5571267_1	264198.Reut_C6079	5.266e-148	481.0	COG2015@1|root,COG2015@2|Bacteria,1R9IE@1224|Proteobacteria,2VKAR@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Alkyl sulfatase and related hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_dimr,Lactamase_B
CMS3_k127_5571267_0	460265.Mnod_3429	1.704e-219	692.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,1JRH7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Flavin-binding monooxygenase-like	-	-	1.14.13.22	ko:K03379	ko00930,ko01120,ko01220,map00930,map01120,map01220	-	R02231,R06622	RC00662,RC01550	ko00000,ko00001,ko01000	-	-	-	FMO-like,Pyr_redox_3
CMS3_k127_5595886_3	765420.OSCT_0910	4.804e-20	98.0	COG0457@1|root,COG1716@1|root,COG4447@1|root,COG0457@2|Bacteria,COG1716@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CarboxypepD_reg,FHA,Kelch_4,NHL,PA14,Peptidase_C11
CMS3_k127_5595886_0	518766.Rmar_2529	1.732e-174	557.0	COG0004@1|root,COG0004@2|Bacteria,4NDV2@976|Bacteroidetes,1FJ27@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	PFAM Rh family protein ammonium transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
CMS3_k127_5595886_2	309801.trd_1106	3.296e-47	172.0	COG0347@1|root,COG0347@2|Bacteria,2G9VE@200795|Chloroflexi,27Z5X@189775|Thermomicrobia	189775|Thermomicrobia	K	Nitrogen regulatory protein P-II	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
CMS3_k127_5595886_1	886293.Sinac_3472	2.151e-95	325.0	COG0647@1|root,COG0647@2|Bacteria,2IXDV@203682|Planctomycetes	203682|Planctomycetes	G	Belongs to the HAD-like hydrolase superfamily	-	-	-	ko:K02566	-	-	-	-	ko00000	-	-	-	Hydrolase_6,Hydrolase_like
CMS3_k127_5595886_4	641524.ADICYQ_2911	8.713e-08	57.0	COG3119@1|root,COG3119@2|Bacteria,4NEPB@976|Bacteroidetes	976|Bacteroidetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_5650511_0	1123023.JIAI01000024_gene4225	2.387e-185	593.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4E1U7@85010|Pseudonocardiales	201174|Actinobacteria	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	2.2.1.6,2.5.1.66	ko:K01652,ko:K12673	ko00290,ko00331,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00331,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570,M00674	R00006,R00014,R00226,R03050,R04672,R04673,R05465,R08648	RC00027,RC00106,RC00215,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_5650511_1	596153.Alide_0280	1.256e-127	432.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2VNJN@28216|Betaproteobacteria,4ACBA@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
CMS3_k127_565530_5	1144310.PMI07_004578	7.907e-13	70.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,4B8MQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Thioredoxin	trxA2	-	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
CMS3_k127_565530_0	1502851.FG93_03267	2.3e-79	274.0	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2U3ND@28211|Alphaproteobacteria,3JTH6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
CMS3_k127_565530_3	1128421.JAGA01000001_gene2460	1.454e-41	166.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	ccmG	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
CMS3_k127_565530_4	1169161.KB897727_gene981	8.925e-39	162.0	COG0491@1|root,COG0491@2|Bacteria,2GMSA@201174|Actinobacteria	201174|Actinobacteria	S	Beta-lactamase	ytnP_1	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_565530_1	316274.Haur_3363	1.088e-52	199.0	COG0697@1|root,COG0697@2|Bacteria,2G6ZR@200795|Chloroflexi	200795|Chloroflexi	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_565530_2	321327.CYA_0798	5.148e-42	160.0	COG0328@1|root,COG0328@2|Bacteria,1G12J@1117|Cyanobacteria,1GYK3@1129|Synechococcus	1117|Cyanobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
CMS3_k127_565530_6	383372.Rcas_0143	1.617e-06	61.0	2DE6H@1|root,2ZKPY@2|Bacteria,2G9I8@200795|Chloroflexi,377JX@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5709453_0	561175.KB894093_gene3095	1.084e-104	349.0	COG0053@1|root,COG0053@2|Bacteria,2GKSG@201174|Actinobacteria,4EG1Y@85012|Streptosporangiales	201174|Actinobacteria	P	TIGRFAM cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
CMS3_k127_5709453_1	1380390.JIAT01000011_gene2542	4.391e-36	145.0	COG1595@1|root,COG1595@2|Bacteria,2HGII@201174|Actinobacteria,4CRQ5@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5709453_2	1120972.AUMH01000028_gene676	4.247e-15	82.0	COG2132@1|root,COG3794@1|root,COG2132@2|Bacteria,COG3794@2|Bacteria,1TQJK@1239|Firmicutes,4IRUW@91061|Bacilli	91061|Bacilli	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
CMS3_k127_5746021_8	485913.Krac_12204	2.032e-40	157.0	COG2141@1|root,COG2141@2|Bacteria,2G727@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
CMS3_k127_5746021_1	977880.RALTA_B1890	4.94e-145	476.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VK54@28216|Betaproteobacteria,1KCNC@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
CMS3_k127_5746021_7	1297863.APJF01000001_gene2265	3.637e-47	190.0	COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,2TSTP@28211|Alphaproteobacteria,3JU6V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_5746021_6	1380390.JIAT01000012_gene3181	3.729e-51	201.0	COG2141@1|root,COG2141@2|Bacteria,2GMUP@201174|Actinobacteria,4CQD0@84995|Rubrobacteria	84995|Rubrobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_5746021_2	113395.AXAI01000002_gene5237	9.454e-144	463.0	COG2141@1|root,COG2141@2|Bacteria,1R76K@1224|Proteobacteria,2VF18@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_5746021_0	1089544.KB912942_gene4161	2.136e-151	509.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_5746021_4	749414.SBI_06014	4.799e-83	286.0	COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
CMS3_k127_5746021_5	882083.SacmaDRAFT_2036	7.892e-71	249.0	COG1028@1|root,COG1028@2|Bacteria,2H0SM@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.100,1.1.1.401	ko:K00059,ko:K21883	ko00051,ko00061,ko00333,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,map00051,map00061,map00333,map00780,map01040,map01100,map01120,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11339,R11671	RC00029,RC00089,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
CMS3_k127_5746021_3	1382356.JQMP01000003_gene2001	2.076e-96	334.0	COG1167@1|root,COG1167@2|Bacteria,2G5XE@200795|Chloroflexi,27Y0D@189775|Thermomicrobia	189775|Thermomicrobia	EK	Alanine-glyoxylate amino-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
CMS3_k127_5751395_8	748280.NH8B_1561	4.263e-22	100.0	COG1359@1|root,COG1359@2|Bacteria,1NBVY@1224|Proteobacteria,2W67Z@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
CMS3_k127_5751395_0	502025.Hoch_5710	1.073e-144	478.0	COG0490@1|root,COG1226@1|root,COG4651@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WK23@28221|Deltaproteobacteria,2YX01@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
CMS3_k127_5751395_7	1002809.SSIL_1838	1.642e-25	123.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HF06@91061|Bacilli,26H34@186818|Planococcaceae	91061|Bacilli	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_5751395_3	1209989.TepiRe1_2048	6.095e-67	239.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,42FXH@68295|Thermoanaerobacterales	186801|Clostridia	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	nikB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS3_k127_5751395_5	1071073.KI530539_gene17	6.768e-59	217.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli,1ZC1H@1386|Bacillus	91061|Bacilli	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
CMS3_k127_5751395_2	314254.OA2633_10679	1.145e-86	294.0	COG1335@1|root,COG1335@2|Bacteria,1N48X@1224|Proteobacteria,2U17G@28211|Alphaproteobacteria,43YZU@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	COG1335 Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS3_k127_5751395_6	767817.Desgi_3530	8.734e-38	162.0	COG3437@1|root,COG5000@1|root,COG3437@2|Bacteria,COG5000@2|Bacteria,1TQ0S@1239|Firmicutes,24Y6H@186801|Clostridia,267AY@186807|Peptococcaceae	186801|Clostridia	T	diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HAMP,HD,HD_5,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3,dCache_1
CMS3_k127_5751395_1	953739.SVEN_0577	1.666e-87	312.0	COG4191@1|root,COG4191@2|Bacteria,2GMRD@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,cNMP_binding
CMS3_k127_5751395_4	211165.AJLN01000061_gene4018	1.138e-64	224.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria,1JHD5@1189|Stigonemataceae	1117|Cyanobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
CMS3_k127_5756335_0	439235.Dalk_4476	9.176e-137	458.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42PUP@68525|delta/epsilon subdivisions,2WMAH@28221|Deltaproteobacteria,2MN7Y@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS3_k127_5756335_1	309801.trd_1505	6.708e-93	320.0	COG0612@1|root,COG0612@2|Bacteria,2G672@200795|Chloroflexi,27XSH@189775|Thermomicrobia	189775|Thermomicrobia	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_5756335_4	469383.Cwoe_4473	8.423e-10	70.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	2.7.1.190	ko:K17910	-	-	R11229	RC00002,RC00078	ko00000,ko01000,ko01504	-	-	-	APH
CMS3_k127_5756335_2	1299327.I546_4511	6.073e-30	128.0	COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria,23BEX@1762|Mycobacteriaceae	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_5756335_3	1121430.JMLG01000001_gene2333	2.05e-12	79.0	COG2301@1|root,COG2301@2|Bacteria,1TPDY@1239|Firmicutes,24AIH@186801|Clostridia,260C4@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
CMS3_k127_5761339_3	1449069.JMLO01000014_gene4353	8.637e-16	82.0	2DMP1@1|root,32SS8@2|Bacteria,2IJVX@201174|Actinobacteria,4G1PJ@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3237)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3237
CMS3_k127_5761339_1	767817.Desgi_3217	3.102e-78	271.0	COG4221@1|root,COG4221@2|Bacteria,1UIB4@1239|Firmicutes,25EG6@186801|Clostridia,265GT@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_5761339_2	1214101.BN159_1370	1.218e-77	269.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	MA20_13990	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	Lactamase_B
CMS3_k127_5761339_0	1380394.JADL01000007_gene4673	3.557e-134	434.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales	28211|Alphaproteobacteria	C	III protein, CoA-transferase family	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_5804781_4	266117.Rxyl_0279	1.183e-59	214.0	COG0066@1|root,COG0066@2|Bacteria,2GJ8Z@201174|Actinobacteria,4CQ8R@84995|Rubrobacteria	84995|Rubrobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
CMS3_k127_5804781_0	525904.Tter_0194	1.551e-215	683.0	COG0065@1|root,COG0065@2|Bacteria,2NP2K@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531,iSB619.SA_RS10700	Aconitase
CMS3_k127_5804781_2	311424.DhcVS_734	2.069e-194	620.0	COG0119@1|root,COG0119@2|Bacteria,2G5V9@200795|Chloroflexi,34CY8@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
CMS3_k127_5804781_3	765420.OSCT_0353	1.551e-138	447.0	COG0059@1|root,COG0059@2|Bacteria,2G5NP@200795|Chloroflexi,3758Y@32061|Chloroflexia	32061|Chloroflexia	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
CMS3_k127_5804781_5	264732.Moth_2257	1.085e-53	196.0	COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia,42GAW@68295|Thermoanaerobacterales	186801|Clostridia	E	Acetolactate synthase, small subunit	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
CMS3_k127_5804781_1	311424.DhcVS_737	5.435e-212	674.0	COG0028@1|root,COG0028@2|Bacteria,2G5Q7@200795|Chloroflexi,34CWN@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_5812000_2	1380390.JIAT01000014_gene6112	1.529e-06	50.0	COG3324@1|root,COG3324@2|Bacteria,2HRAM@201174|Actinobacteria,4CT7I@84995|Rubrobacteria	84995|Rubrobacteria	E	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5812000_0	398525.KB900701_gene298	2.549e-92	312.0	COG0388@1|root,COG0388@2|Bacteria,1MWQG@1224|Proteobacteria,2TYHX@28211|Alphaproteobacteria,3JTNQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.5.1	ko:K01501	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
CMS3_k127_5812000_1	1297742.A176_03357	1.242e-86	301.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,42Q75@68525|delta/epsilon subdivisions,2WMDY@28221|Deltaproteobacteria,2YUG7@29|Myxococcales	28221|Deltaproteobacteria	L	DEAD/H associated	lhr1	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
CMS3_k127_5829724_2	298655.KI912266_gene5821	1.219e-35	140.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_5829724_0	1429916.X566_06480	1.513e-153	494.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TT8C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_5829724_1	58123.JOFJ01000014_gene4980	3.941e-69	243.0	COG1028@1|root,COG1028@2|Bacteria,2IEID@201174|Actinobacteria	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_5829724_4	649639.Bcell_1962	0.0002042	51.0	COG0398@1|root,COG0398@2|Bacteria,1V3J1@1239|Firmicutes,4HHXX@91061|Bacilli,1ZEPX@1386|Bacillus	91061|Bacilli	S	SNARE associated Golgi protein	ytxB	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS3_k127_5829724_3	977880.RALTA_A0472	4.41e-24	116.0	COG0697@1|root,COG0697@2|Bacteria,1R6KH@1224|Proteobacteria,2VNEM@28216|Betaproteobacteria,1K5AJ@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_5861505_1	483219.LILAB_13530	4.345e-30	126.0	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,42TBH@68525|delta/epsilon subdivisions,2WPJ5@28221|Deltaproteobacteria,2YW2S@29|Myxococcales	28221|Deltaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
CMS3_k127_5861505_4	745411.B3C1_00230	1.243e-06	56.0	COG2259@1|root,COG2259@2|Bacteria,1RBZP@1224|Proteobacteria,1S28E@1236|Gammaproteobacteria,1J5W4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
CMS3_k127_5861505_5	1089546.AQUI01000002_gene4369	2.301e-05	53.0	COG2030@1|root,COG2030@2|Bacteria,2IFCJ@201174|Actinobacteria,4095C@622450|Actinopolysporales	201174|Actinobacteria	I	N-terminal half of MaoC dehydratase	hadB	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
CMS3_k127_5861505_3	562970.Btus_0372	4.91e-13	81.0	COG2030@1|root,COG2030@2|Bacteria,1V4PQ@1239|Firmicutes,4HGYW@91061|Bacilli,278N3@186823|Alicyclobacillaceae	91061|Bacilli	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
CMS3_k127_5861505_2	748247.AZKH_2144	7.894e-21	106.0	COG0613@1|root,COG0613@2|Bacteria,1RF04@1224|Proteobacteria,2W16S@28216|Betaproteobacteria,2KYJS@206389|Rhodocyclales	206389|Rhodocyclales	S	PHP-associated	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
CMS3_k127_5861505_0	1382356.JQMP01000003_gene1363	1.466e-49	193.0	COG0491@1|root,COG0491@2|Bacteria,2GBAB@200795|Chloroflexi,27YH3@189775|Thermomicrobia	189775|Thermomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_5926451_4	1283287.KB822575_gene456	4.886e-28	120.0	COG1595@1|root,COG1595@2|Bacteria,2GJER@201174|Actinobacteria,4DPVS@85009|Propionibacteriales	201174|Actinobacteria	K	ECF sigma factor	adsA	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5926451_3	1333856.L686_13965	1.73e-60	220.0	COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,1S3TR@1236|Gammaproteobacteria,1Z0WV@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_5926451_2	926560.KE387023_gene3649	1.549e-60	220.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	ytnP	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_5926451_6	1265310.CCBD010000046_gene2426	2.518e-16	84.0	COG3871@1|root,COG3871@2|Bacteria,2I2TZ@201174|Actinobacteria,2398S@1762|Mycobacteriaceae	201174|Actinobacteria	S	F420-dependent enzyme	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
CMS3_k127_5926451_1	330084.JNYZ01000046_gene1933	8.254e-62	226.0	COG0491@1|root,COG0491@2|Bacteria,2GMSA@201174|Actinobacteria	201174|Actinobacteria	S	Beta-lactamase	ytnP_1	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_5926451_0	552811.Dehly_1382	2.566e-106	356.0	COG0115@1|root,COG0115@2|Bacteria,2G5PM@200795|Chloroflexi,34CQR@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CMS3_k127_5926451_5	357808.RoseRS_3398	8.876e-19	97.0	2EQGV@1|root,33I2V@2|Bacteria,2G7HG@200795|Chloroflexi,375SC@32061|Chloroflexia	32061|Chloroflexia	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_5
CMS3_k127_5928466_3	525368.HMPREF0591_0025	2.702e-60	226.0	COG0425@1|root,COG0425@2|Bacteria,2I4E3@201174|Actinobacteria,23B3Y@1762|Mycobacteriaceae	201174|Actinobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5928466_4	1172186.KB911465_gene4220	1.874e-50	188.0	COG3832@1|root,COG3832@2|Bacteria,2I8ND@201174|Actinobacteria,236RA@1762|Mycobacteriaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_5928466_6	290399.Arth_3553	1.668e-28	119.0	COG0640@1|root,COG0640@2|Bacteria,2IQ55@201174|Actinobacteria,1WA3B@1268|Micrococcaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
CMS3_k127_5928466_2	1382306.JNIM01000001_gene1299	1.465e-75	270.0	COG1929@1|root,COG1929@2|Bacteria	2|Bacteria	G	organic acid phosphorylation	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
CMS3_k127_5928466_7	644968.DFW101_2482	6.319e-05	49.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2M7VB@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
CMS3_k127_5928466_1	1089553.Tph_c06510	1.604e-85	297.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,42EYC@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
CMS3_k127_5928466_0	635013.TherJR_2764	3.004e-86	301.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,26093@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS3_k127_5928466_5	1382306.JNIM01000001_gene724	9.967e-29	128.0	COG0392@1|root,COG0392@2|Bacteria,2G6EN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
CMS3_k127_5930297_4	1463921.JODF01000010_gene1744	0.000314	48.0	COG0183@1|root,COG0183@2|Bacteria,2GKFR@201174|Actinobacteria	201174|Actinobacteria	I	lipid-transfer protein	ltp2	-	-	-	-	-	-	-	-	-	-	-	Thiolase_N
CMS3_k127_5930297_2	1123504.JQKD01000012_gene1257	1.302e-62	233.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VN0B@28216|Betaproteobacteria,4AH2J@80864|Comamonadaceae	28216|Betaproteobacteria	C	CoA-transferase family III	bbsE	-	2.8.3.15	ko:K07543	ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220	M00418	R05588	RC00014,RC00137	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
CMS3_k127_5930297_1	1380356.JNIK01000003_gene1286	3.383e-78	277.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,4EU9D@85013|Frankiales	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_5930297_3	118005.AWNK01000008_gene470	9.454e-29	117.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rbpA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS3_k127_5930297_0	525904.Tter_0396	8.099e-81	279.0	COG2141@1|root,COG2141@2|Bacteria,2NQM2@2323|unclassified Bacteria	2|Bacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_5933687_7	1108045.GORHZ_040_00180	7.883e-84	287.0	COG0426@1|root,COG0426@2|Bacteria,2GJT6@201174|Actinobacteria	201174|Actinobacteria	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
CMS3_k127_5933687_12	68223.JNZY01000037_gene7502	1.087e-38	153.0	COG1309@1|root,COG1309@2|Bacteria,2IKK0@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_5933687_13	649747.HMPREF0083_02273	2.025e-24	119.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,4HA6Y@91061|Bacilli,26R1K@186822|Paenibacillaceae	91061|Bacilli	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
CMS3_k127_5933687_25	562970.Btus_2659	1.609e-05	56.0	COG4097@1|root,COG4097@2|Bacteria,1VAMR@1239|Firmicutes,4HKN3@91061|Bacilli,278P1@186823|Alicyclobacillaceae	91061|Bacilli	P	Ferric reductase like transmembrane component	-	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
CMS3_k127_5933687_15	1283299.AUKG01000001_gene2970	2.344e-20	99.0	COG1595@1|root,COG1595@2|Bacteria,2HRFN@201174|Actinobacteria,4CTEH@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5933687_5	525904.Tter_2549	1.32e-96	333.0	COG3850@1|root,COG3850@2|Bacteria,2NS42@2323|unclassified Bacteria	2|Bacteria	T	histidine kinase dimerisation and phosphoacceptor region	-	-	2.7.13.3	ko:K03406,ko:K07673,ko:K07675	ko02020,ko02030,map02020,map02030	M00471,M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,LapD_MoxY_N
CMS3_k127_5933687_20	665959.HMPREF1013_05117	5.61e-09	69.0	COG4454@1|root,COG4454@2|Bacteria,1V23W@1239|Firmicutes,4HGGT@91061|Bacilli,1ZEGR@1386|Bacillus	91061|Bacilli	P	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
CMS3_k127_5933687_11	479434.Sthe_0156	8e-65	239.0	COG3850@1|root,COG3850@2|Bacteria,2GBH4@200795|Chloroflexi,27XF0@189775|Thermomicrobia	189775|Thermomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
CMS3_k127_5933687_10	1382356.JQMP01000004_gene592	1.671e-65	233.0	COG2197@1|root,COG2197@2|Bacteria,2G8EU@200795|Chloroflexi,27XKP@189775|Thermomicrobia	189775|Thermomicrobia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_5933687_1	197221.22294486	1.499e-316	989.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1G0GP@1117|Cyanobacteria	1117|Cyanobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	Intein_splicing,PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS3_k127_5933687_17	469382.Hbor_11170	3.879e-15	82.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,23VQJ@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_5933687_23	388051.AUFE01000032_gene3533	7.11e-08	58.0	COG2972@1|root,COG2972@2|Bacteria	2|Bacteria	T	Histidine kinase	mcp64H-2	-	-	ko:K02660,ko:K03406,ko:K11525	ko02020,ko02025,ko02030,map02020,map02025,map02030	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	2TM,4HB_MCP_1,DUF3365,GAF,HAMP,MCPsignal,dCache_1
CMS3_k127_5933687_19	1038860.AXAP01000008_gene5995	2.621e-11	68.0	COG0446@1|root,COG2146@1|root,COG4638@1|root,COG0446@2|Bacteria,COG2146@2|Bacteria,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2U2S3@28211|Alphaproteobacteria,3JXN4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	1.14.12.1,1.14.13.172	ko:K16319,ko:K18242	ko00626,ko00627,ko01120,map00626,map00627,map01120	M00637,M00638	R00823,R00825,R07709,R07710	RC00192,RC00490	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C,Rieske,Ring_hydroxyl_A
CMS3_k127_5933687_8	344747.PM8797T_13620	8.414e-77	268.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS3_k127_5933687_26	1385935.N836_34480	0.0001156	51.0	COG2197@1|root,COG2197@2|Bacteria,1G5A4@1117|Cyanobacteria,1H7R3@1150|Oscillatoriales	1117|Cyanobacteria	KT	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_5933687_24	1536773.R70331_08575	8.793e-06	57.0	2EFDH@1|root,3396B@2|Bacteria,1VI1N@1239|Firmicutes,4HQ2X@91061|Bacilli,26Z6S@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5933687_6	1123024.AUII01000016_gene1301	1.113e-94	325.0	COG2227@1|root,COG2227@2|Bacteria,2I3C3@201174|Actinobacteria,4EE7R@85010|Pseudonocardiales	201174|Actinobacteria	H	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
CMS3_k127_5933687_21	953739.SVEN_0067	3.936e-08	61.0	COG3832@1|root,COG3832@2|Bacteria,2IHP6@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
CMS3_k127_5933687_9	196162.Noca_4918	4.545e-76	275.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,4DT1D@85009|Propionibacteriales	201174|Actinobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD,HD_5
CMS3_k127_5933687_0	330214.NIDE3519	0.0	1083.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3
CMS3_k127_5933687_16	926554.KI912671_gene265	1.024e-16	92.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	CCP_MauG,Copper-bind,Cu-oxidase_3,Cupredoxin_1
CMS3_k127_5933687_4	1353531.AZNX01000030_gene5858	7.43e-105	355.0	COG0277@1|root,COG1960@1|root,COG0277@2|Bacteria,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2TTF6@28211|Alphaproteobacteria,4BDFV@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.14.14.12	ko:K16047	ko00984,ko01100,ko01120,map00984,map01100,map01120	-	R09819	RC00236	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
CMS3_k127_5933687_18	909613.UO65_3729	2.655e-13	79.0	COG3764@1|root,COG3764@2|Bacteria,2I91T@201174|Actinobacteria,4E5B9@85010|Pseudonocardiales	201174|Actinobacteria	M	Sortase family	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
CMS3_k127_5933687_2	1229780.BN381_80376	1.572e-169	549.0	COG2132@1|root,COG3794@1|root,COG2132@2|Bacteria,COG3794@2|Bacteria,2HZAX@201174|Actinobacteria,3UXS1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
CMS3_k127_5933687_3	1089544.KB912942_gene4161	6.762e-131	443.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_5937614_2	100226.SCO0163	4.898e-15	81.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,2GM3U@201174|Actinobacteria	201174|Actinobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
CMS3_k127_5937614_3	596154.Alide2_4043	9.011e-07	59.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2VJM3@28216|Betaproteobacteria,4AC1Z@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Methyltransferase type 11	ubiE_1	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS3_k127_5937614_1	1382306.JNIM01000001_gene3677	2.801e-62	229.0	COG2141@1|root,COG2141@2|Bacteria,2G727@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
CMS3_k127_5937614_0	292459.STH1647	1.101e-104	368.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia	186801|Clostridia	L	Belongs to the DEAD box helicase family	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
CMS3_k127_5937614_4	745014.OMB55_00013700	3.153e-05	47.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA,Redoxin
CMS3_k127_5937914_9	383372.Rcas_3537	6.125e-50	194.0	COG0265@1|root,COG0265@2|Bacteria,2G8RK@200795|Chloroflexi,377YF@32061|Chloroflexia	32061|Chloroflexia	C	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	1.3.1.74	ko:K08070	-	-	-	-	ko00000,ko01000	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_5937914_11	316274.Haur_1676	1.603e-34	141.0	COG0782@1|root,COG0782@2|Bacteria,2G6U9@200795|Chloroflexi,375ID@32061|Chloroflexia	32061|Chloroflexia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
CMS3_k127_5937914_2	1121468.AUBR01000035_gene1398	5.92e-145	474.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,42EMJ@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
CMS3_k127_5937914_15	1128421.JAGA01000002_gene1456	2.816e-21	102.0	COG0637@1|root,COG0637@2|Bacteria,2NQ0R@2323|unclassified Bacteria	2|Bacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CpXC,HAD_2
CMS3_k127_5937914_13	1124991.MU9_2132	1.778e-22	104.0	COG1051@1|root,COG1051@2|Bacteria,1N5QT@1224|Proteobacteria,1SABD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS3_k127_5937914_3	1128421.JAGA01000002_gene397	1.293e-132	444.0	COG0172@1|root,COG0172@2|Bacteria,2NNRH@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	GO:0000049,GO:0000166,GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016020,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046983,GO:0070905,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_3528,iSDY_1059.SDY_2368	Seryl_tRNA_N,tRNA-synt_2b
CMS3_k127_5937914_17	105422.BBPM01000040_gene849	3.956e-13	78.0	COG3189@1|root,COG3189@2|Bacteria,2IQC0@201174|Actinobacteria,2NJZ6@228398|Streptacidiphilus	201174|Actinobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
CMS3_k127_5937914_14	767029.HMPREF9154_1169	2.751e-21	108.0	COG1146@1|root,COG1146@2|Bacteria,2IKVN@201174|Actinobacteria,4DR37@85009|Propionibacteriales	201174|Actinobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	fdxA	-	-	-	-	-	-	-	-	-	-	-	Fer4
CMS3_k127_5937914_8	316274.Haur_0312	5.408e-86	300.0	COG4106@1|root,COG4106@2|Bacteria	2|Bacteria	FG	trans-aconitate 2-methyltransferase activity	-	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS3_k127_5937914_12	743718.Isova_2630	1.097e-28	121.0	2EGCD@1|root,33A46@2|Bacteria,2I0MJ@201174|Actinobacteria,4F4SW@85017|Promicromonosporaceae	201174|Actinobacteria	S	Septum formation	-	-	-	-	-	-	-	-	-	-	-	-	Septum_form
CMS3_k127_5937914_4	1333998.M2A_3075	3.679e-125	409.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,2TSIV@28211|Alphaproteobacteria,4BRMY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Fructose-bisphosphate aldolase class-I	fbaB	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
CMS3_k127_5937914_18	562982.HMPREF0432_01212	1.662e-05	55.0	COG0791@1|root,COG1388@1|root,COG0791@2|Bacteria,COG1388@2|Bacteria,1V7MV@1239|Firmicutes,4ITPA@91061|Bacilli,3WEFS@539002|Bacillales incertae sedis	91061|Bacilli	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	LysM,NLPC_P60
CMS3_k127_5937914_10	926550.CLDAP_24450	5.345e-49	190.0	2EZVX@1|root,33T0B@2|Bacteria,2G87X@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5937914_1	469383.Cwoe_4213	2.269e-157	504.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4CPSD@84995|Rubrobacteria	84995|Rubrobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.24,4.1.3.25	ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,map00630,map00660,map00680,map00720,map01120,map01200	M00346,M00373,M00376	R00237,R00473,R00934	RC00307,RC00308,RC00311,RC00407,RC00502,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
CMS3_k127_5937914_0	469383.Cwoe_4214	1.49e-159	513.0	COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	-	-	6.2.1.18	ko:K15232	ko00720,ko01100,ko01120,ko01200,map00720,map01100,map01120,map01200	M00173	R01322	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2
CMS3_k127_5937914_5	1380390.JIAT01000010_gene3560	2.09e-113	381.0	COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,4CSIF@84995|Rubrobacteria	84995|Rubrobacteria	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,Succ_CoA_lig
CMS3_k127_5937914_7	66874.JOFS01000005_gene4043	6.093e-95	326.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	lipP	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_5937914_6	1454004.AW11_01666	1.297e-107	359.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VH1N@28216|Betaproteobacteria	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.12	ko:K14448	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09293	RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_5952233_2	649831.L083_3599	0.0001582	52.0	COG1228@1|root,COG4946@1|root,COG1228@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Amidohydro_1,PD40,PG_binding_1,Pkinase,TolB_N
CMS3_k127_5952233_1	521719.ATXQ01000006_gene1332	4.042e-07	59.0	COG2010@1|root,COG2010@2|Bacteria,1RGXM@1224|Proteobacteria,1S976@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
CMS3_k127_5952233_3	187272.Mlg_1384	0.0001812	47.0	COG3462@1|root,COG3462@2|Bacteria,1NGXC@1224|Proteobacteria,1TKC3@1236|Gammaproteobacteria,1X1RM@135613|Chromatiales	135613|Chromatiales	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
CMS3_k127_5952233_0	543632.JOJL01000016_gene8763	6.102e-09	62.0	COG2801@1|root,COG2801@2|Bacteria,2GN25@201174|Actinobacteria	201174|Actinobacteria	L	Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve_3
CMS3_k127_5960225_8	2074.JNYD01000003_gene3844	5.117e-53	192.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_5960225_1	298655.KI912266_gene6242	1.413e-112	385.0	COG1804@1|root,COG1804@2|Bacteria,2IB9E@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_5960225_4	113395.AXAI01000002_gene5235	4.104e-93	329.0	COG2141@1|root,COG2141@2|Bacteria,1MWDV@1224|Proteobacteria,2TV51@28211|Alphaproteobacteria,3JWDH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_5960225_11	83219.PM02_04430	3.83e-36	151.0	COG0251@1|root,COG0251@2|Bacteria,1QDUS@1224|Proteobacteria,2U8KG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
CMS3_k127_5960225_16	194439.CT1708	2.211e-13	79.0	COG0546@1|root,COG0546@2|Bacteria,1FDVN@1090|Chlorobi	1090|Chlorobi	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
CMS3_k127_5960225_2	314285.KT71_03092	3.948e-99	341.0	COG3246@1|root,COG3246@2|Bacteria,1R4YF@1224|Proteobacteria,1SK8Q@1236|Gammaproteobacteria,1J82J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Pfam:Kce	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
CMS3_k127_5960225_7	255470.cbdbA1037	5.285e-66	243.0	COG1173@1|root,COG1173@2|Bacteria,2G9WH@200795|Chloroflexi,34DKE@301297|Dehalococcoidia	301297|Dehalococcoidia	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
CMS3_k127_5960225_6	608506.COB47_1725	4.681e-71	252.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,42FJK@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	oppB	-	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
CMS3_k127_5960225_3	311424.DhcVS_932	7.213e-99	344.0	COG4166@1|root,COG4166@2|Bacteria,2G81T@200795|Chloroflexi,34DKF@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
CMS3_k127_5960225_5	1209984.BN978_02863	6.457e-85	295.0	COG0451@1|root,COG0451@2|Bacteria,2I2UT@201174|Actinobacteria,23559@1762|Mycobacteriaceae	201174|Actinobacteria	M	UDP-glucose 4-epimerase	galE1	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS3_k127_5960225_13	1396141.BATP01000007_gene5551	9.479e-31	128.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,46SRG@74201|Verrucomicrobia,2ITHX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Competence-damaged protein	-	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
CMS3_k127_5960225_12	1380346.JNIH01000040_gene2649	5.259e-32	138.0	COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CMS3_k127_5960225_15	1128421.JAGA01000002_gene161	8.374e-17	94.0	COG0799@1|root,COG0799@2|Bacteria,2NPYI@2323|unclassified Bacteria	2|Bacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113	2.7.7.18	ko:K00969,ko:K09710	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	RsfS
CMS3_k127_5960225_9	1121422.AUMW01000011_gene119	1.487e-49	185.0	COG0105@1|root,COG0105@2|Bacteria,1V44G@1239|Firmicutes,24JM5@186801|Clostridia,261SD@186807|Peptococcaceae	186801|Clostridia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
CMS3_k127_5960225_17	1232410.KI421418_gene2270	5.878e-12	75.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,42RIT@68525|delta/epsilon subdivisions,2WP64@28221|Deltaproteobacteria,43UNS@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Glycoprotease family	yeaZ	-	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CMS3_k127_5960225_14	1121428.DESHY_160205___1	4.592e-29	123.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,2621R@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised P-loop hydrolase UPF0079	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
CMS3_k127_5960225_10	552811.Dehly_1128	4.066e-47	187.0	COG0611@1|root,COG0611@2|Bacteria,2G6SH@200795|Chloroflexi,34CMT@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
CMS3_k127_5960225_0	309801.trd_0652	7.578e-276	876.0	COG0188@1|root,COG0188@2|Bacteria,2G5Q2@200795|Chloroflexi,27Y2U@189775|Thermomicrobia	189775|Thermomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CMS3_k127_5960225_18	33876.JNXY01000014_gene3985	0.0007031	47.0	COG0454@1|root,COG0456@2|Bacteria,2IQC8@201174|Actinobacteria,4DEVT@85008|Micromonosporales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_6007114_6	1382356.JQMP01000003_gene2153	4.652e-53	195.0	COG2120@1|root,COG2120@2|Bacteria,2G6FB@200795|Chloroflexi,27XV7@189775|Thermomicrobia	189775|Thermomicrobia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS3_k127_6007114_4	316274.Haur_2249	5.278e-102	347.0	COG0438@1|root,COG0438@2|Bacteria,2G5KS@200795|Chloroflexi,374UR@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_6007114_5	756272.Plabr_2904	1.298e-64	229.0	COG0302@1|root,COG0302@2|Bacteria,2IYUA@203682|Planctomycetes	203682|Planctomycetes	H	PFAM GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
CMS3_k127_6007114_2	358681.BBR47_18550	1.004e-126	414.0	COG0498@1|root,COG0498@2|Bacteria,1TP25@1239|Firmicutes,4HA1F@91061|Bacilli,26RAH@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0016829,GO:0016835,GO:0016838,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS06615,iYO844.BSU32250	PALP
CMS3_k127_6007114_3	1120985.AUMI01000015_gene1653	5.083e-102	347.0	COG0460@1|root,COG0460@2|Bacteria,1TQ2H@1239|Firmicutes,4H2NA@909932|Negativicutes	909932|Negativicutes	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
CMS3_k127_6007114_15	479434.Sthe_1448	4.487e-07	62.0	COG0760@1|root,COG0760@2|Bacteria,2G6RV@200795|Chloroflexi,27XG1@189775|Thermomicrobia	189775|Thermomicrobia	O	SurA N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase_3
CMS3_k127_6007114_13	903814.ELI_4585	1.591e-20	96.0	COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,24MQV@186801|Clostridia,25WV7@186806|Eubacteriaceae	186801|Clostridia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
CMS3_k127_6007114_8	552811.Dehly_0754	3.803e-49	178.0	COG0629@1|root,COG0629@2|Bacteria,2G6YE@200795|Chloroflexi,34DBK@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Single-strand binding protein family	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
CMS3_k127_6007114_14	1382306.JNIM01000001_gene3507	7.143e-16	85.0	COG0360@1|root,COG0360@2|Bacteria,2G7DG@200795|Chloroflexi	200795|Chloroflexi	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
CMS3_k127_6007114_1	1206732.BAGD01000054_gene1961	2.093e-130	427.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4FWX1@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_6007114_0	867903.ThesuDRAFT_01781	4.938e-159	512.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,3WCFT@538999|Clostridiales incertae sedis	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
CMS3_k127_6007114_7	292459.STH124	2.39e-49	193.0	COG1920@1|root,COG1920@2|Bacteria,1V86Y@1239|Firmicutes,24K51@186801|Clostridia	186801|Clostridia	S	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6007114_12	349161.Dred_3081	3.568e-26	118.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,2627P@186807|Peptococcaceae	186801|Clostridia	F	PFAM Phosphoribosyltransferase	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
CMS3_k127_6007114_11	357808.RoseRS_3952	1.698e-26	126.0	COG0477@1|root,COG0477@2|Bacteria,2GA6R@200795|Chloroflexi,3782R@32061|Chloroflexia	32061|Chloroflexia	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_6007114_9	1128421.JAGA01000002_gene1039	2.383e-41	164.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,2NR4E@2323|unclassified Bacteria	2|Bacteria	H	MoaE protein	moaD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.7.7.77,2.8.1.12,4.6.1.17	ko:K03635,ko:K03636,ko:K03637,ko:K03752,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395,R11372,R11581	RC02507,RC03425	ko00000,ko00001,ko01000	-	-	iE2348C_1286.E2348C_0736,iEC55989_1330.EC55989_0827,iG2583_1286.G2583_1012,iLF82_1304.LF82_1368,iNRG857_1313.NRG857_03495,iSFV_1184.SFV_0767,iSF_1195.SF0734,iSFxv_1172.SFxv_0800,iSSON_1240.SSON_0763,iS_1188.S0775	MoaE,ThiS
CMS3_k127_6007114_10	28258.KP05_00950	2.316e-27	127.0	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,1S3XB@1236|Gammaproteobacteria,1XJQ3@135619|Oceanospirillales	135619|Oceanospirillales	F	ADP-ribose pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
CMS3_k127_6051124_0	247633.GP2143_13151	4.887e-123	402.0	COG1960@1|root,COG1960@2|Bacteria,1NRP4@1224|Proteobacteria,1SKQM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_6051124_2	269796.Rru_A2021	1.257e-17	97.0	COG0708@1|root,COG0708@2|Bacteria,1NYWF@1224|Proteobacteria	1224|Proteobacteria	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS3_k127_6051124_1	1449063.JMLS01000003_gene1946	6.934e-35	141.0	COG1051@1|root,COG1051@2|Bacteria,1V6PH@1239|Firmicutes,4IQ1N@91061|Bacilli,27665@186822|Paenibacillaceae	91061|Bacilli	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS3_k127_6071025_2	479434.Sthe_3015	4.691e-119	406.0	COG0318@1|root,COG0318@2|Bacteria,2G7PF@200795|Chloroflexi,27XJD@189775|Thermomicrobia	189775|Thermomicrobia	IQ	Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily	menE	-	6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_6071025_6	1121945.ATXS01000001_gene2504	1.074e-41	168.0	COG4948@1|root,arCOG01168@2157|Archaea,2XU6X@28890|Euryarchaeota,23SAR@183963|Halobacteria	183963|Halobacteria	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
CMS3_k127_6071025_4	469383.Cwoe_3570	1.619e-81	284.0	COG1575@1|root,COG1575@2|Bacteria,2GJBS@201174|Actinobacteria,4CQ7T@84995|Rubrobacteria	84995|Rubrobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
CMS3_k127_6071025_1	1356854.N007_20610	1.591e-128	419.0	COG0447@1|root,COG0447@2|Bacteria,1UHNU@1239|Firmicutes,4HAD0@91061|Bacilli	91061|Bacilli	H	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_6071025_5	479434.Sthe_3023	3.161e-81	279.0	COG2267@1|root,COG2267@2|Bacteria,2GBHH@200795|Chloroflexi,27Y8T@189775|Thermomicrobia	189775|Thermomicrobia	I	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)	menH	-	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
CMS3_k127_6071025_0	309801.trd_A0261	1.16e-158	518.0	COG1165@1|root,COG1165@2|Bacteria,2G6JR@200795|Chloroflexi,27XZC@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	-	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N
CMS3_k127_6071025_3	867845.KI911784_gene3297	1.526e-83	293.0	COG1169@1|root,COG1169@2|Bacteria,2G5RQ@200795|Chloroflexi,375P4@32061|Chloroflexia	32061|Chloroflexia	HQ	TIGRFAM isochorismate synthase	-	-	5.4.4.2	ko:K02361,ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
CMS3_k127_6071025_8	176946.XP_007434795.1	5.843e-06	59.0	KOG1565@1|root,KOG1565@2759|Eukaryota,39HBF@33154|Opisthokonta,3BKAC@33208|Metazoa,3D46B@33213|Bilateria,482MG@7711|Chordata,498XQ@7742|Vertebrata	33208|Metazoa	OW	Matrixin	MMP27	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0012505,GO:0016020,GO:0019898,GO:0031090,GO:0031312,GO:0031984,GO:0042175,GO:0042406,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0098827	3.4.24.34	ko:K01402,ko:K07994,ko:K08005	ko04657,ko04926,map04657,map04926	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Hemopexin,PG_binding_1,Peptidase_M10
CMS3_k127_6071025_7	247639.MGP2080_08529	1.663e-17	95.0	2DBU1@1|root,2ZB3C@2|Bacteria,1NB4B@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6118245_2	43759.JNWK01000003_gene1442	2.329e-27	121.0	COG2306@1|root,COG2306@2|Bacteria,2GJP9@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF402)	-	-	-	-	-	-	-	-	-	-	-	-	DUF402
CMS3_k127_6118245_1	1122918.KB907267_gene27	4.189e-33	134.0	COG1051@1|root,COG1051@2|Bacteria,1UNWG@1239|Firmicutes,4IUSN@91061|Bacilli,277R4@186822|Paenibacillaceae	91061|Bacilli	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS3_k127_6118245_0	1122929.KB908218_gene1614	4.495e-44	164.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TR3P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_6126424_1	1120934.KB894452_gene2647	1.198e-33	147.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GMN4@201174|Actinobacteria,4E1FZ@85010|Pseudonocardiales	201174|Actinobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppsA	-	2.7.9.2	ko:K01007,ko:K21787	ko00333,ko00620,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00333,map00620,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00374,M00837,M00838	R00199,R11662,R11673	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS3_k127_6126424_3	331869.BAL199_30142	9.081e-32	128.0	COG3801@1|root,COG3801@2|Bacteria,1RGZ3@1224|Proteobacteria,2U95Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
CMS3_k127_6126424_0	1048339.KB913029_gene4494	1.569e-63	226.0	28HG7@1|root,2Z7S3@2|Bacteria,2GMJK@201174|Actinobacteria,4ESGD@85013|Frankiales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N,Wyosine_form
CMS3_k127_6126424_2	1532557.JL37_19680	5.25e-32	140.0	COG4948@1|root,COG4948@2|Bacteria,1NWGK@1224|Proteobacteria	1224|Proteobacteria	M	Enolase C-terminal domain-like	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
CMS3_k127_6126424_4	1382306.JNIM01000001_gene3677	9.95e-21	106.0	COG2141@1|root,COG2141@2|Bacteria,2G727@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
CMS3_k127_6141581_1	1120971.AUCA01000030_gene43	7.039e-34	140.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HCH3@91061|Bacilli,2790J@186823|Alicyclobacillaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	yngF	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_6141581_0	1243664.CAVL020000025_gene1259	5.861e-45	168.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HCH3@91061|Bacilli,1ZMKF@1386|Bacillus	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_6145258_0	745014.OMB55_00013700	2.079e-42	165.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA,Redoxin
CMS3_k127_6145258_3	469383.Cwoe_2923	1.914e-10	63.0	2A5VU@1|root,30UMP@2|Bacteria,2HRRK@201174|Actinobacteria,4CTU7@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6145258_2	324602.Caur_0123	3.688e-23	107.0	COG2346@1|root,COG2346@2|Bacteria,2G9T7@200795|Chloroflexi,377F9@32061|Chloroflexia	32061|Chloroflexia	S	PFAM globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
CMS3_k127_6145258_1	861299.J421_3907	7.698e-25	107.0	COG0500@1|root,COG2226@2|Bacteria,1ZSNE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
CMS3_k127_6167511_1	926569.ANT_29030	4.981e-19	90.0	2EAGR@1|root,334K0@2|Bacteria,2G730@200795|Chloroflexi	200795|Chloroflexi	S	PFAM zinc finger, SWIM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
CMS3_k127_6167511_0	324602.Caur_1931	1.314e-132	436.0	COG0304@1|root,COG0304@2|Bacteria,2G7RK@200795|Chloroflexi,376IR@32061|Chloroflexia	32061|Chloroflexia	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS3_k127_6167511_2	644282.Deba_0817	2.691e-05	50.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,42N08@68525|delta/epsilon subdivisions,2WIW9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2475	Mur_ligase_C,Mur_ligase_M
CMS3_k127_6204751_16	59538.XP_005968778.1	8.78e-08	56.0	COG1062@1|root,KOG0022@2759|Eukaryota,397PJ@33154|Opisthokonta,3BIQH@33208|Metazoa,3CYWE@33213|Bilateria,4871P@7711|Chordata,491PB@7742|Vertebrata,3J1Y5@40674|Mammalia	2759|Eukaryota	Q	alcohol dehydrogenase (NAD) activity	ADH1	GO:0000302,GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009410,GO:0009413,GO:0009414,GO:0009415,GO:0009628,GO:0009636,GO:0009651,GO:0009719,GO:0009725,GO:0009737,GO:0009743,GO:0009744,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0014070,GO:0014074,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0031000,GO:0032355,GO:0033993,GO:0034285,GO:0036270,GO:0036293,GO:0042221,GO:0042493,GO:0042542,GO:0042802,GO:0042803,GO:0043279,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046686,GO:0046983,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0055114,GO:0065007,GO:0070482,GO:0071944,GO:0080134,GO:0080135,GO:0097305,GO:1900037,GO:1900039,GO:1901698,GO:1901700	1.1.1.1,1.1.1.284	ko:K00001,ko:K00121,ko:K02267,ko:K13980,ko:K18857	ko00010,ko00071,ko00190,ko00350,ko00592,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,ko05204,map00010,map00071,map00190,map00350,map00592,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map04260,map04714,map04932,map05010,map05012,map05016,map05204	M00154	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310,R10783	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	3.D.4.11,3.D.4.8	-	-	ADH_N,ADH_zinc_N
CMS3_k127_6204751_9	547163.BN979_03554	1.736e-69	250.0	COG1735@1|root,COG1735@2|Bacteria,2GMZ6@201174|Actinobacteria,2360H@1762|Mycobacteriaceae	201174|Actinobacteria	S	Phosphotriesterase	php	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
CMS3_k127_6204751_3	926550.CLDAP_08240	1.888e-110	366.0	COG1126@1|root,COG1126@2|Bacteria,2G5UB@200795|Chloroflexi	200795|Chloroflexi	E	PFAM ABC transporter related	-	-	3.6.3.21	ko:K02028,ko:K09972	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
CMS3_k127_6204751_5	383372.Rcas_1456	1.784e-77	287.0	COG0765@1|root,COG0765@2|Bacteria,2G845@200795|Chloroflexi,376Y4@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
CMS3_k127_6204751_6	1460640.JCM19046_2836	4.098e-76	269.0	COG4597@1|root,COG4597@2|Bacteria,1U5AA@1239|Firmicutes,4HD9P@91061|Bacilli,1ZCH2@1386|Bacillus	91061|Bacilli	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K09970	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
CMS3_k127_6204751_4	1173264.KI913949_gene225	3.235e-90	310.0	COG0834@1|root,COG0834@2|Bacteria,1G0K4@1117|Cyanobacteria,1H88R@1150|Oscillatoriales	1117|Cyanobacteria	ET	PFAM Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
CMS3_k127_6204751_0	323259.Mhun_1561	4.85e-129	426.0	COG0427@1|root,arCOG06124@2157|Archaea,2XVQA@28890|Euryarchaeota	28890|Euryarchaeota	C	acetyl-CoA hydrolase	-	-	2.8.3.18	ko:K18118,ko:K18288	ko00020,ko00620,ko00650,ko00660,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00650,map00660,map01100,map01110,map01120,map01130,map01200	M00009,M00011	R02407,R10343,R10600	RC00012,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
CMS3_k127_6204751_14	679197.HMPREF9336_01445	5.443e-30	138.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_6204751_1	485913.Krac_11674	5.167e-124	406.0	COG2141@1|root,COG2141@2|Bacteria,2G878@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_6204751_2	195250.CM001776_gene2578	2.51e-119	404.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	oxc	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0008150,GO:0008152,GO:0008949,GO:0009056,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019752,GO:0019842,GO:0030554,GO:0030976,GO:0032553,GO:0032555,GO:0032559,GO:0033609,GO:0033611,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043531,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046872,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0071704,GO:0097159,GO:0097367,GO:0104004,GO:1901265,GO:1901363,GO:1901575,GO:1901681	4.1.1.8	ko:K01577	ko00630,ko01100,map00630,map01100	-	R01908	RC00620	ko00000,ko00001,ko01000	-	-	iEcSMS35_1347.EcSMS35_2523,iNJ661.Rv0118c	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_6204751_13	314285.KT71_07874	5.635e-43	167.0	COG1024@1|root,COG1024@2|Bacteria,1NJ9M@1224|Proteobacteria,1SMR0@1236|Gammaproteobacteria,1J9KU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_6204751_7	247633.GP2143_12286	2.911e-72	253.0	COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria,1SZ1J@1236|Gammaproteobacteria,1JATZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_6204751_12	298655.KI912267_gene7609	3.338e-56	212.0	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4EUBY@85013|Frankiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_6204751_10	314278.NB231_13791	2.816e-68	241.0	COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,1S3Y4@1236|Gammaproteobacteria,1WYGC@135613|Chromatiales	135613|Chromatiales	S	Alpha/beta hydrolase family	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	-
CMS3_k127_6204751_11	87626.PTD2_11689	4.195e-68	244.0	COG0652@1|root,COG0652@2|Bacteria,1RBX1@1224|Proteobacteria,1SYJW@1236|Gammaproteobacteria,2Q28R@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
CMS3_k127_6204751_8	518766.Rmar_1742	4.169e-70	250.0	COG2133@1|root,COG2133@2|Bacteria,4PKJE@976|Bacteroidetes,1FJG8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS3_k127_6204751_15	279714.FuraDRAFT_3510	1.257e-27	115.0	COG0673@1|root,COG0673@2|Bacteria,1NKUI@1224|Proteobacteria,2VUT6@28216|Betaproteobacteria,2KTQX@206351|Neisseriales	206351|Neisseriales	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_6236473_0	589924.Ferp_1270	3.004e-08	65.0	COG1716@1|root,arCOG06549@1|root,arCOG05332@2157|Archaea,arCOG06549@2157|Archaea,2Y2TB@28890|Euryarchaeota,246ST@183980|Archaeoglobi	183980|Archaeoglobi	C	Zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
CMS3_k127_628225_14	381764.Fnod_1127	7.177e-20	100.0	COG0198@1|root,COG0198@2|Bacteria,2GD31@200918|Thermotogae	200918|Thermotogae	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
CMS3_k127_628225_8	479434.Sthe_1046	4.358e-52	188.0	COG0093@1|root,COG0093@2|Bacteria,2G6MZ@200795|Chloroflexi,27YG0@189775|Thermomicrobia	189775|Thermomicrobia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
CMS3_k127_628225_13	555088.DealDRAFT_1514	8.748e-21	98.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,42K48@68298|Syntrophomonadaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
CMS3_k127_628225_15	469371.Tbis_0570	4.712e-07	60.0	COG0255@1|root,COG0255@2|Bacteria,2IQ6V@201174|Actinobacteria,4E5RB@85010|Pseudonocardiales	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
CMS3_k127_628225_7	644966.Tmar_2288	3.062e-52	188.0	COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,3WCGY@538999|Clostridiales incertae sedis	186801|Clostridia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
CMS3_k127_628225_2	765420.OSCT_0193	5.837e-77	263.0	COG0092@1|root,COG0092@2|Bacteria,2G691@200795|Chloroflexi,3757R@32061|Chloroflexia	32061|Chloroflexia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
CMS3_k127_628225_11	555079.Toce_0124	1.057e-25	112.0	COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,24JF4@186801|Clostridia,42GWK@68295|Thermoanaerobacterales	186801|Clostridia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
CMS3_k127_628225_10	575605.ACQN01000026_gene822	6.77e-33	129.0	COG0185@1|root,COG0185@2|Bacteria,1V6CX@1239|Firmicutes,4HIG0@91061|Bacilli,3F6XP@33958|Lactobacillaceae	91061|Bacilli	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
CMS3_k127_628225_1	552811.Dehly_1094	2.069e-115	377.0	COG0090@1|root,COG0090@2|Bacteria,2G65E@200795|Chloroflexi,34CKM@301297|Dehalococcoidia	301297|Dehalococcoidia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
CMS3_k127_628225_12	316274.Haur_4917	5.625e-25	107.0	COG0089@1|root,COG0089@2|Bacteria,2G73T@200795|Chloroflexi,375Y1@32061|Chloroflexia	32061|Chloroflexia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
CMS3_k127_628225_5	1033740.CAEW01000034_gene1587	2.379e-55	201.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,4HB01@91061|Bacilli,26DJA@186818|Planococcaceae	91061|Bacilli	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
CMS3_k127_628225_3	324602.Caur_2369	2.093e-65	235.0	COG0087@1|root,COG0087@2|Bacteria,2G6DQ@200795|Chloroflexi,375C3@32061|Chloroflexia	32061|Chloroflexia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
CMS3_k127_628225_9	1382306.JNIM01000001_gene3550	1.944e-42	157.0	COG0051@1|root,COG0051@2|Bacteria,2G6RB@200795|Chloroflexi	200795|Chloroflexi	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
CMS3_k127_628225_0	243231.GSU2860	1.689e-279	876.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS3_k127_628225_6	479434.Sthe_1032	4.858e-54	193.0	COG0049@1|root,COG0049@2|Bacteria,2G6GR@200795|Chloroflexi,27Y66@189775|Thermomicrobia	189775|Thermomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
CMS3_k127_628225_4	1128421.JAGA01000002_gene690	5.952e-64	221.0	COG0048@1|root,COG0048@2|Bacteria,2NPA7@2323|unclassified Bacteria	2|Bacteria	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
CMS3_k127_6390073_6	557436.Lreu_0789	0.000122	50.0	COG1247@1|root,COG1247@2|Bacteria,1V3V3@1239|Firmicutes,4HHNY@91061|Bacilli,3F70T@33958|Lactobacillaceae	91061|Bacilli	M	Acetyltransferase (GNAT) domain	ywnH	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_3,Acetyltransf_4
CMS3_k127_6390073_7	1197130.BAFM01000004_gene992	0.0002116	52.0	COG1514@1|root,arCOG01736@2157|Archaea,2Y0VA@28890|Euryarchaeota,23Y3H@183963|Halobacteria	183963|Halobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
CMS3_k127_6390073_0	552811.Dehly_0915	0.0	1414.0	COG0458@1|root,COG0458@2|Bacteria,2G5NX@200795|Chloroflexi,34D66@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
CMS3_k127_6390073_4	1121430.JMLG01000008_gene1543	1.585e-22	109.0	COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,24GK6@186801|Clostridia,261XX@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	ppaX	-	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS3_k127_6390073_3	243164.DET1203	9.907e-49	186.0	COG0543@1|root,COG0543@2|Bacteria,2G75X@200795|Chloroflexi,34D0J@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
CMS3_k127_6390073_5	1173023.KE650771_gene5107	6.753e-19	99.0	COG1432@1|root,COG1432@2|Bacteria,1G3J6@1117|Cyanobacteria,1JHFM@1189|Stigonemataceae	1117|Cyanobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
CMS3_k127_6390073_1	926550.CLDAP_03340	1.247e-94	331.0	COG0489@1|root,COG0489@2|Bacteria,2G60P@200795|Chloroflexi	200795|Chloroflexi	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
CMS3_k127_6390073_2	443144.GM21_1820	1.408e-94	327.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,43TBH@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with NAD( ) as electron acceptor	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.5.2	ko:K00254,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
CMS3_k127_6413226_1	1429916.X566_18545	1.754e-84	304.0	COG1804@1|root,COG1804@2|Bacteria,1NSWZ@1224|Proteobacteria,2U2UE@28211|Alphaproteobacteria,3JWDN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_6413226_7	1123278.KB893587_gene555	1.487e-07	61.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PM8I@976|Bacteroidetes,47KK7@768503|Cytophagia	976|Bacteroidetes	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
CMS3_k127_6413226_6	525368.HMPREF0591_0024	1.665e-13	77.0	2BZG6@1|root,2ZH9N@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6413226_8	595536.ADVE02000001_gene1491	9.303e-05	49.0	COG2331@1|root,COG2331@2|Bacteria,1N8DC@1224|Proteobacteria,2UH8G@28211|Alphaproteobacteria,370KF@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
CMS3_k127_6413226_3	525368.HMPREF0591_0025	1.657e-44	177.0	COG0425@1|root,COG0425@2|Bacteria,2I4E3@201174|Actinobacteria,23B3Y@1762|Mycobacteriaceae	201174|Actinobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6413226_2	525368.HMPREF0591_0025	1.768e-59	222.0	COG0425@1|root,COG0425@2|Bacteria,2I4E3@201174|Actinobacteria,23B3Y@1762|Mycobacteriaceae	201174|Actinobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6413226_0	1041522.MCOL_V202830	8.061e-121	404.0	COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,235AT@1762|Mycobacteriaceae	201174|Actinobacteria	C	PFAM CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_6413226_4	1224163.B841_04985	5.08e-25	118.0	COG0491@1|root,COG0491@2|Bacteria,2IAWR@201174|Actinobacteria,22M2U@1653|Corynebacteriaceae	201174|Actinobacteria	S	Beta-lactamase superfamily domain	gloB	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_6413226_5	1032480.MLP_49430	6.473e-19	88.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria,4DP4K@85009|Propionibacteriales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	int	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
CMS3_k127_6485798_3	234267.Acid_5780	6.317e-43	166.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,TPR_8,Trans_reg_C
CMS3_k127_6485798_8	375451.RD1_1567	5.924e-09	63.0	COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,2UGBE@28211|Alphaproteobacteria,2P4WB@2433|Roseobacter	28211|Alphaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	nirC	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K19344	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
CMS3_k127_6485798_6	926560.KE387023_gene3616	1.633e-21	98.0	COG2128@1|root,COG2128@2|Bacteria,1WJIC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_6485798_5	604331.AUHY01000009_gene404	1.28e-21	96.0	COG2128@1|root,COG2128@2|Bacteria,1WJIC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_6485798_7	637389.Acaty_c0690	5.867e-14	73.0	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,1SEIJ@1236|Gammaproteobacteria,2NDDB@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
CMS3_k127_6485798_9	525904.Tter_2561	0.0003691	48.0	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
CMS3_k127_6485798_0	469383.Cwoe_3624	1.61e-125	432.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4CR8Y@84995|Rubrobacteria	84995|Rubrobacteria	T	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
CMS3_k127_6485798_4	251221.35212921	5.904e-26	122.0	COG0683@1|root,COG0683@2|Bacteria,1G16P@1117|Cyanobacteria	1117|Cyanobacteria	E	'ABC-type branched-chain amino acid transport	natB	-	-	ko:K01999,ko:K11954	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	ANF_receptor,Peripla_BP_6
CMS3_k127_6485798_2	653045.Strvi_6126	3.748e-65	235.0	COG2070@1|root,COG2070@2|Bacteria,2IN9Q@201174|Actinobacteria	201174|Actinobacteria	S	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
CMS3_k127_6485798_1	1205680.CAKO01000030_gene4923	3.43e-76	260.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQU2@28211|Alphaproteobacteria,2JV5K@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
CMS3_k127_6584539_0	1382356.JQMP01000003_gene1403	1.703e-58	208.0	2DBIJ@1|root,2Z9G2@2|Bacteria,2G896@200795|Chloroflexi,27XN4@189775|Thermomicrobia	189775|Thermomicrobia	S	Phage capsid family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_capsid
CMS3_k127_6584539_2	311424.DhcVS_296	1.816e-33	138.0	2A4RY@1|root,30TDC@2|Bacteria,2GB08@200795|Chloroflexi,34DPC@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6584539_1	311424.DhcVS_298	9.561e-35	153.0	2BPNS@1|root,32IFU@2|Bacteria,2GAX7@200795|Chloroflexi,34DII@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6599359_7	3218.PP1S24_152V6.1	1.602e-11	76.0	2926D@1|root,2R92T@2759|Eukaryota,37JID@33090|Viridiplantae,3G8IN@35493|Streptophyta	35493|Streptophyta	S	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
CMS3_k127_6599359_3	1121382.JQKG01000017_gene1859	6.932e-41	169.0	COG0642@1|root,COG4585@1|root,COG2205@2|Bacteria,COG4585@2|Bacteria,1WJNH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HATPase_c_2,HisKA_3,PAS,PAS_4,PAS_8
CMS3_k127_6599359_1	1121382.JQKG01000017_gene1858	7.846e-67	234.0	COG2197@1|root,COG2197@2|Bacteria,1WI4W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_6599359_2	929556.Solca_2233	8.705e-58	213.0	COG0437@1|root,COG0437@2|Bacteria,4NI8R@976|Bacteroidetes	976|Bacteroidetes	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11
CMS3_k127_6599359_0	1379698.RBG1_1C00001G0857	1.547e-104	363.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	1379698.RBG1_1C00001G0857|-	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6599359_8	1035308.AQYY01000002_gene988	6.445e-05	51.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	qcrC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K00406,ko:K03889	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00151,M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3
CMS3_k127_6599359_6	3218.PP1S24_152V6.1	2.229e-12	80.0	2926D@1|root,2R92T@2759|Eukaryota,37JID@33090|Viridiplantae,3G8IN@35493|Streptophyta	35493|Streptophyta	S	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
CMS3_k127_6599359_5	1219045.BV98_003395	4.255e-14	78.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,2KAFT@204457|Sphingomonadales	204457|Sphingomonadales	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_6646037_0	66875.JODY01000006_gene2209	3.392e-70	249.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the amidase family	amiC_1	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
CMS3_k127_6646037_1	1449126.JQKL01000076_gene39	3.749e-26	123.0	COG0477@1|root,COG2814@2|Bacteria,1TRUT@1239|Firmicutes,25E84@186801|Clostridia	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_670206_1	1313172.YM304_37140	4.958e-36	147.0	COG2334@1|root,COG2334@2|Bacteria,2H4PV@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1679)	-	-	-	-	-	-	-	-	-	-	-	-	EcKinase
CMS3_k127_670206_0	1123060.JONP01000003_gene387	3.405e-50	189.0	COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2U0CV@28211|Alphaproteobacteria,2JW09@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.14.13.235	ko:K22027	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
CMS3_k127_6715924_2	1038869.AXAN01000006_gene964	1.275e-62	228.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2VIAK@28216|Betaproteobacteria,1JZQ7@119060|Burkholderiaceae	28216|Betaproteobacteria	FL	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ada	GO:0001130,GO:0003674,GO:0003700,GO:0003824,GO:0003908,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006355,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016740,GO:0016741,GO:0018125,GO:0018193,GO:0018198,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044728,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070988,GO:0071704,GO:0080090,GO:0080111,GO:0090304,GO:0140110,GO:1901360,GO:1901564,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,HTH_AraC,Methyltransf_1N
CMS3_k127_6715924_3	1111479.AXAR01000001_gene21	9.162e-33	133.0	COG1853@1|root,COG1853@2|Bacteria,1V1X6@1239|Firmicutes,4HGJ2@91061|Bacilli,279EA@186823|Alicyclobacillaceae	91061|Bacilli	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
CMS3_k127_6715924_0	67275.JOAP01000002_gene7084	3.338e-142	469.0	COG3391@1|root,COG3391@2|Bacteria,2IBCA@201174|Actinobacteria	201174|Actinobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
CMS3_k127_6715924_1	388413.ALPR1_14479	7.028e-78	274.0	COG2133@1|root,COG2133@2|Bacteria,4NF0B@976|Bacteroidetes,47K2Q@768503|Cytophagia	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,GSDH
CMS3_k127_6715924_4	882082.SaccyDRAFT_3132	2.73e-15	84.0	COG0491@1|root,COG0491@2|Bacteria,2H8JM@201174|Actinobacteria,4E4HF@85010|Pseudonocardiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_6755708_5	926550.CLDAP_09500	3.569e-05	49.0	COG2318@1|root,COG2318@2|Bacteria,2G91B@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS3_k127_6755708_4	67356.KL575586_gene442	1.531e-11	74.0	COG1917@1|root,COG1917@2|Bacteria,2IFSF@201174|Actinobacteria	201174|Actinobacteria	IQ	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_6755708_1	479434.Sthe_2154	6.43e-84	286.0	COG0411@1|root,COG0411@2|Bacteria	2|Bacteria	E	ABC transporter	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
CMS3_k127_6755708_3	1232437.KL662012_gene1400	1.145e-62	233.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42YP9@68525|delta/epsilon subdivisions,2WTKT@28221|Deltaproteobacteria,2MN4Y@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
CMS3_k127_6755708_2	1121939.L861_22340	3.671e-72	265.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,1RNDV@1236|Gammaproteobacteria,1XH8D@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS3_k127_6755708_0	479434.Sthe_2151	2.015e-84	293.0	COG4177@1|root,COG4177@2|Bacteria,2G6D8@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS3_k127_675704_1	479434.Sthe_2520	6.793e-82	290.0	COG0154@1|root,COG0154@2|Bacteria,2G5T0@200795|Chloroflexi,27Y0A@189775|Thermomicrobia	2|Bacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS3_k127_675704_3	525904.Tter_0754	1.285e-23	108.0	298YA@1|root,32VWC@2|Bacteria,2NRHS@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
CMS3_k127_675704_4	1202768.JROF01000001_gene1566	7.552e-18	93.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX4R@28890|Euryarchaeota,23VKS@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_675704_0	1382306.JNIM01000001_gene3339	2.429e-231	731.0	COG0129@1|root,COG0129@2|Bacteria,2G67Z@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
CMS3_k127_675704_2	1457250.BBMO01000003_gene3262	2.49e-25	117.0	COG0702@1|root,arCOG03015@2157|Archaea,2XT7V@28890|Euryarchaeota,23T9H@183963|Halobacteria	183963|Halobacteria	M	Nucleoside-diphosphate-sugar epimerases	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
CMS3_k127_6763935_0	1499680.CCFE01000023_gene2582	8.866e-118	397.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4IN2H@91061|Bacilli,1ZMNA@1386|Bacillus	91061|Bacilli	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_6763935_8	394221.Mmar10_2330	1.04e-13	82.0	2CDDX@1|root,3058G@2|Bacteria,1QYT0@1224|Proteobacteria,2UETN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Alkylmercury lyase	-	-	4.99.1.2	ko:K00221	-	-	-	-	ko00000,ko01000	-	-	-	MerB
CMS3_k127_6763935_6	1313172.YM304_31800	3.243e-29	122.0	COG2010@1|root,COG2010@2|Bacteria,2H614@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
CMS3_k127_6763935_1	1123368.AUIS01000008_gene2277	1.329e-94	319.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria,2NCYJ@225057|Acidithiobacillales	1236|Gammaproteobacteria	P	cation diffusion facilitator family transporter	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
CMS3_k127_6763935_5	1142394.PSMK_26780	2.616e-34	151.0	COG0589@1|root,COG1808@1|root,COG0589@2|Bacteria,COG1808@2|Bacteria,2J3I1@203682|Planctomycetes	203682|Planctomycetes	T	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
CMS3_k127_6763935_2	690850.Desaf_2499	1.151e-71	251.0	COG0500@1|root,COG2226@2|Bacteria,1MVXG@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
CMS3_k127_6763935_4	690850.Desaf_2498	6.747e-52	205.0	28KBH@1|root,2Z9YH@2|Bacteria,1R3W2@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6763935_7	497965.Cyan7822_5490	2.131e-20	96.0	COG1917@1|root,COG1917@2|Bacteria,1G8HF@1117|Cyanobacteria	1117|Cyanobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_6763935_3	526227.Mesil_3294	7.292e-65	236.0	COG0683@1|root,COG0683@2|Bacteria,1WKAP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
CMS3_k127_6763935_9	1005048.CFU_0684	5.332e-12	73.0	COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria,2VHQ4@28216|Betaproteobacteria,474I6@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
CMS3_k127_6768239_0	234267.Acid_5837	0.0	1024.0	COG1201@1|root,COG1201@2|Bacteria,3Y348@57723|Acidobacteria	57723|Acidobacteria	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
CMS3_k127_6773077_17	1144275.COCOR_07109	5.152e-29	123.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,42UEE@68525|delta/epsilon subdivisions,2WQHS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS3_k127_6773077_22	365046.Rta_07180	4.482e-19	98.0	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2VQTE@28216|Betaproteobacteria,4A9S9@80864|Comamonadaceae	28216|Betaproteobacteria	G	phosphoglycerate mutase	gpmB	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
CMS3_k127_6773077_0	309801.trd_0668	1.162e-153	513.0	COG1193@1|root,COG1193@2|Bacteria,2G5R8@200795|Chloroflexi,27XIK@189775|Thermomicrobia	189775|Thermomicrobia	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
CMS3_k127_6773077_3	404589.Anae109_4157	1.937e-132	438.0	COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,2YU5T@29|Myxococcales	28221|Deltaproteobacteria	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
CMS3_k127_6773077_4	243164.DET0600	1.404e-116	387.0	COG0075@1|root,COG0075@2|Bacteria,2G5P3@200795|Chloroflexi,34CWR@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_6773077_1	552811.Dehly_0744	1.947e-136	453.0	COG0111@1|root,COG0111@2|Bacteria,2G67B@200795|Chloroflexi,34CNE@301297|Dehalococcoidia	301297|Dehalococcoidia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS3_k127_6773077_9	404589.Anae109_1414	5.164e-73	262.0	COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42NTB@68525|delta/epsilon subdivisions,2WKNX@28221|Deltaproteobacteria,2Z31V@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
CMS3_k127_6773077_23	1118059.CAHC01000009_gene1185	2.39e-13	75.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia	186801|Clostridia	FG	PFAM Histidine triad (HIT) protein	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
CMS3_k127_6773077_6	767434.Fraau_0411	2.63e-88	299.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1X3QU@135614|Xanthomonadales	135614|Xanthomonadales	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
CMS3_k127_6773077_12	446462.Amir_1203	3.864e-60	235.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4DXGV@85010|Pseudonocardiales	201174|Actinobacteria	S	DNA internalization-related competence protein ComEC Rec2	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
CMS3_k127_6773077_21	593907.Celgi_1213	1.975e-21	100.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4F2PZ@85016|Cellulomonadaceae	201174|Actinobacteria	L	Helix-hairpin-helix motif	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
CMS3_k127_6773077_5	879310.HMPREF9162_1483	1.624e-90	308.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,4H278@909932|Negativicutes	909932|Negativicutes	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS3_k127_6773077_11	309801.trd_0688	3.59e-62	224.0	COG1624@1|root,COG1624@2|Bacteria,2G6J7@200795|Chloroflexi,27XJ7@189775|Thermomicrobia	189775|Thermomicrobia	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	-	-	-	-	-	-	-	-	-	-	DisA_N
CMS3_k127_6773077_19	767817.Desgi_0603	3.001e-25	121.0	COG4856@1|root,COG4856@2|Bacteria,1TSIV@1239|Firmicutes,24GKC@186801|Clostridia,2612S@186807|Peptococcaceae	186801|Clostridia	S	PFAM YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
CMS3_k127_6773077_2	357808.RoseRS_2146	1.612e-132	445.0	COG1160@1|root,COG1160@2|Bacteria,2G5M0@200795|Chloroflexi,375A1@32061|Chloroflexia	32061|Chloroflexia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
CMS3_k127_6773077_18	110662.Syncc9605_2099	1.334e-28	129.0	COG0344@1|root,COG0344@2|Bacteria,1G3HV@1117|Cyanobacteria,1GYXY@1129|Synechococcus	1117|Cyanobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
CMS3_k127_6773077_8	316274.Haur_3883	9.575e-74	261.0	COG0240@1|root,COG0240@2|Bacteria,2G5W5@200795|Chloroflexi	200795|Chloroflexi	I	NAD-dependent glycerol-3-phosphate dehydrogenase domain protein	gpsA	GO:0003674,GO:0003824,GO:0004367,GO:0006072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0046167,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
CMS3_k127_6773077_16	525904.Tter_0952	1.365e-31	137.0	COG1413@1|root,COG1413@2|Bacteria,2NR83@2323|unclassified Bacteria	2|Bacteria	C	E-Z type HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS3_k127_6773077_15	485913.Krac_12558	4.544e-32	134.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	-	-	2.7.7.53,3.6.1.13,3.6.1.55	ko:K01515,ko:K03574,ko:K19710	ko00230,map00230	-	R00126,R01054,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000,ko03400	-	-	-	NUDIX
CMS3_k127_6773077_14	311424.DhcVS_464	3.217e-32	132.0	COG1670@1|root,COG1670@2|Bacteria,2GAMB@200795|Chloroflexi,34CRJ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
CMS3_k127_6773077_10	1123023.JIAI01000003_gene2846	1.321e-65	235.0	COG1028@1|root,COG1028@2|Bacteria,2H8QY@201174|Actinobacteria	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
CMS3_k127_6773077_7	1449353.JQMQ01000005_gene5424	2.714e-75	264.0	COG1028@1|root,COG1028@2|Bacteria,2GN6U@201174|Actinobacteria,2NGAN@228398|Streptacidiphilus	201174|Actinobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
CMS3_k127_6773077_13	439235.Dalk_3908	1.29e-38	149.0	COG2030@1|root,COG2030@2|Bacteria,1Q5QU@1224|Proteobacteria,431N3@68525|delta/epsilon subdivisions,2WWWX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
CMS3_k127_6773077_20	439235.Dalk_3909	4.391e-24	109.0	COG2030@1|root,COG2030@2|Bacteria,1Q5QX@1224|Proteobacteria,431N8@68525|delta/epsilon subdivisions,2WWXI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
CMS3_k127_6805900_0	1205680.CAKO01000037_gene1298	7.519e-38	144.0	COG0439@1|root,COG1038@1|root,COG4799@1|root,COG0439@2|Bacteria,COG1038@2|Bacteria,COG4799@2|Bacteria,1MU4H@1224|Proteobacteria,2TWYZ@28211|Alphaproteobacteria,2JZ2C@204441|Rhodospirillales	204441|Rhodospirillales	I	Biotin carboxylase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
CMS3_k127_6805900_1	1463909.KL585951_gene2423	4.191e-20	96.0	COG3360@1|root,COG3360@2|Bacteria,2IQ6Z@201174|Actinobacteria	201174|Actinobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
CMS3_k127_6805900_2	1123504.JQKD01000040_gene2800	4.913e-08	61.0	COG0770@1|root,COG2843@1|root,COG4627@1|root,COG0770@2|Bacteria,COG2843@2|Bacteria,COG4627@2|Bacteria,1P1MG@1224|Proteobacteria,2VIGZ@28216|Betaproteobacteria,4AEVE@80864|Comamonadaceae	28216|Betaproteobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	Mur_ligase_M,PGA_cap
CMS3_k127_6825901_0	311424.DhcVS_295	1.982e-43	162.0	2DBIJ@1|root,2Z9G2@2|Bacteria,2G896@200795|Chloroflexi,34DN7@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Phage capsid family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_capsid
CMS3_k127_6825901_2	861299.J421_6000	1.789e-19	95.0	COG0789@1|root,COG0789@2|Bacteria,1ZVAN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	MerR, DNA binding	-	-	-	ko:K13639	-	-	-	-	ko00000,ko03000	-	-	-	-
CMS3_k127_6825901_3	187303.BN69_0898	2.892e-10	69.0	2E48M@1|root,32Z4G@2|Bacteria,1N6NZ@1224|Proteobacteria,2UH8Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_36460	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6825901_4	479434.Sthe_0024	3.485e-07	62.0	2DCSV@1|root,2ZF7N@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6825901_1	1268072.PSAB_16245	4.303e-42	174.0	COG3173@1|root,COG3173@2|Bacteria,1UIXX@1239|Firmicutes,4ISW9@91061|Bacilli,26VY7@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF1679)	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS3_k127_6827156_2	1245469.S58_35020	3.512e-26	123.0	COG1407@1|root,COG1407@2|Bacteria,1N407@1224|Proteobacteria,2UQ3I@28211|Alphaproteobacteria,3K2YA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS3_k127_6827156_1	1278073.MYSTI_06609	2.885e-28	119.0	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,43BFC@68525|delta/epsilon subdivisions,2X6TQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
CMS3_k127_6827156_0	448385.sce2281	9.902e-84	298.0	COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,42NX3@68525|delta/epsilon subdivisions,2WME4@28221|Deltaproteobacteria,2YY6M@29|Myxococcales	28221|Deltaproteobacteria	L	High confidence in function and specificity	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
CMS3_k127_6843807_0	1030157.AFMP01000040_gene1551	6.779e-107	363.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSZ8@28211|Alphaproteobacteria,2K8YM@204457|Sphingomonadales	204457|Sphingomonadales	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_6843807_1	1206732.BAGD01000054_gene1961	2.861e-103	355.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4FWX1@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_6843807_2	1429916.X566_17260	1.058e-44	171.0	COG3217@1|root,COG3217@2|Bacteria	2|Bacteria	S	molybdenum ion binding	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
CMS3_k127_6863302_0	1210884.HG799463_gene9849	8.333e-57	200.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2IYT8@203682|Planctomycetes	2|Bacteria	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS3_k127_6875412_1	1041522.MCOL_V204530	2.653e-19	102.0	COG1804@1|root,COG1804@2|Bacteria,2I8ZJ@201174|Actinobacteria,237MT@1762|Mycobacteriaceae	201174|Actinobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_6875412_0	521098.Aaci_1851	1.808e-36	154.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli	91061|Bacilli	C	acyl-CoA transferases carnitine dehydratase	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_6876282_4	2074.JNYD01000024_gene2844	6.246e-26	117.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_6876282_6	1146883.BLASA_1347	2.444e-08	65.0	2DXTJ@1|root,346GW@2|Bacteria,2H9GA@201174|Actinobacteria	201174|Actinobacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6876282_1	1229780.BN381_70002	2.09e-132	437.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,3UW8N@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
CMS3_k127_6876282_5	710421.Mycch_1621	7.649e-18	89.0	2956B@1|root,2ZSIU@2|Bacteria,2ISPI@201174|Actinobacteria,23B2N@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6876282_2	889378.Spiaf_2789	1.435e-111	372.0	COG3288@1|root,COG3288@2|Bacteria,2J63R@203691|Spirochaetes	203691|Spirochaetes	C	TIGRFAM NAD(P) transhydrogenase, alpha subunit	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
CMS3_k127_6876282_3	1121406.JAEX01000007_gene2380	3.265e-26	117.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,42WKN@68525|delta/epsilon subdivisions,2WRXH@28221|Deltaproteobacteria,2MCPQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
CMS3_k127_6876282_0	889378.Spiaf_2787	5.841e-158	513.0	COG1282@1|root,COG1282@2|Bacteria,2J693@203691|Spirochaetes	203691|Spirochaetes	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
CMS3_k127_6877358_2	86416.Clopa_4210	8.464e-09	58.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,36EVT@31979|Clostridiaceae	186801|Clostridia	P	Ammonium Transporter	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	iHN637.CLJU_c42670	Ammonium_transp
CMS3_k127_6877358_1	1229780.BN381_150106	9.552e-42	156.0	COG0347@1|root,COG0347@2|Bacteria,2IKN1@201174|Actinobacteria,3UWT8@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Nitrogen regulatory protein P-II	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
CMS3_k127_6877358_0	1123060.JONP01000021_gene3725	4.093e-59	231.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,2JPGY@204441|Rhodospirillales	204441|Rhodospirillales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
CMS3_k127_6894142_17	463191.SSEG_00207	1.289e-21	94.0	COG0030@1|root,COG0030@2|Bacteria,2GIZ8@201174|Actinobacteria	201174|Actinobacteria	J	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS3_k127_6894142_9	1430331.EP10_07445	5.369e-59	215.0	COG0289@1|root,COG0289@2|Bacteria,1TR9D@1239|Firmicutes,4HA5X@91061|Bacilli,1WF82@129337|Geobacillus	91061|Bacilli	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU22490	DapB_C,DapB_N
CMS3_k127_6894142_1	525904.Tter_1789	1.333e-215	699.0	COG1185@1|root,COG1185@2|Bacteria,2NNX7@2323|unclassified Bacteria	2|Bacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
CMS3_k127_6894142_16	266117.Rxyl_1417	1.031e-29	120.0	COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4CQF0@84995|Rubrobacteria	84995|Rubrobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
CMS3_k127_6894142_14	1048339.KB913029_gene4254	2.368e-34	151.0	COG0671@1|root,COG0671@2|Bacteria,2GMYU@201174|Actinobacteria	201174|Actinobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
CMS3_k127_6894142_2	671143.DAMO_0754	4.209e-124	415.0	COG0260@1|root,COG0260@2|Bacteria,2NNKH@2323|unclassified Bacteria	2|Bacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141	3.4.11.1,3.4.11.5	ko:K01255,ko:K01259	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00135,R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
CMS3_k127_6894142_15	1207058.L53_11265	1.259e-31	129.0	2E1KM@1|root,32WY3@2|Bacteria,1N5IW@1224|Proteobacteria,2UDKY@28211|Alphaproteobacteria,43ZXA@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Methylmuconolactone methyl-isomerase	-	-	-	-	-	-	-	-	-	-	-	-	EthD
CMS3_k127_6894142_20	595537.Varpa_2308	2.049e-08	64.0	COG0346@1|root,COG0346@2|Bacteria,1Q06I@1224|Proteobacteria,2W4W9@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_6894142_21	1158614.I592_03886	2.943e-05	54.0	COG4502@1|root,COG4502@2|Bacteria,1V87A@1239|Firmicutes,4HJ5I@91061|Bacilli,4B2AJ@81852|Enterococcaceae	91061|Bacilli	S	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)	-	-	-	-	-	-	-	-	-	-	-	-	NT5C
CMS3_k127_6894142_4	926569.ANT_11930	1.804e-102	347.0	COG0452@1|root,COG0452@2|Bacteria,2G60D@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
CMS3_k127_6894142_8	1122223.KB890700_gene1978	1.094e-77	273.0	COG1521@1|root,COG1521@2|Bacteria,1WI0G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
CMS3_k127_6894142_3	1382356.JQMP01000003_gene1536	1.045e-118	397.0	COG0593@1|root,COG0593@2|Bacteria,2G5W8@200795|Chloroflexi,27XP6@189775|Thermomicrobia	189775|Thermomicrobia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
CMS3_k127_6894142_5	324602.Caur_1285	2.245e-100	342.0	COG0536@1|root,COG0536@2|Bacteria,2G5ZT@200795|Chloroflexi,3752E@32061|Chloroflexia	32061|Chloroflexia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
CMS3_k127_6894142_13	552811.Dehly_1340	2.749e-38	158.0	COG1057@1|root,COG1057@2|Bacteria,2G6MY@200795|Chloroflexi,34D3W@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
CMS3_k127_6894142_19	1227454.C446_16872	1.579e-12	78.0	arCOG01792@1|root,arCOG01792@2157|Archaea,2XWRG@28890|Euryarchaeota,23VI0@183963|Halobacteria	183963|Halobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_6894142_6	926560.KE387027_gene366	1.329e-98	338.0	COG1680@1|root,COG1680@2|Bacteria,1WJK2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_6894142_7	926560.KE387027_gene366	1.142e-83	297.0	COG1680@1|root,COG1680@2|Bacteria,1WJK2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_6894142_11	1394178.AWOO02000016_gene6846	1.869e-47	178.0	COG0454@1|root,COG0456@2|Bacteria,2I9Y3@201174|Actinobacteria,4ER9I@85012|Streptosporangiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_6894142_12	1386089.N865_19290	1.616e-46	175.0	COG2227@1|root,COG2227@2|Bacteria,2IIE2@201174|Actinobacteria,4FIIB@85021|Intrasporangiaceae	201174|Actinobacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.11	ko:K03428	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R04237	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
CMS3_k127_6894142_0	1499684.CCNP01000010_gene127	1.718e-235	769.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,36DYE@31979|Clostridiaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
CMS3_k127_6894142_18	43759.JNWK01000001_gene5618	5.069e-20	97.0	COG1720@1|root,COG1720@2|Bacteria,2IKKT@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
CMS3_k127_6894142_10	765912.Thimo_1834	2.052e-51	197.0	COG2231@1|root,COG2231@2|Bacteria,1RDJ8@1224|Proteobacteria,1RUHP@1236|Gammaproteobacteria,1WXXG@135613|Chromatiales	135613|Chromatiales	L	PFAM HhH-GPD	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
CMS3_k127_6909506_1	767817.Desgi_0933	3.978e-58	212.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,247WG@186801|Clostridia,25ZXW@186807|Peptococcaceae	186801|Clostridia	I	acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	gcdA	-	4.1.1.70	ko:K01615	ko00362,ko00650,ko01120,map00362,map00650,map01120	-	R03028	RC00832	ko00000,ko00001,ko01000,ko02000	3.B.1.1.3	-	-	Carboxyl_trans
CMS3_k127_6909506_0	1123261.AXDW01000015_gene3389	7.668e-86	310.0	COG1804@1|root,COG1804@2|Bacteria,1NSWZ@1224|Proteobacteria,1S1Z2@1236|Gammaproteobacteria,1X9GX@135614|Xanthomonadales	135614|Xanthomonadales	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_6912646_0	357808.RoseRS_1297	1.936e-88	313.0	COG2366@1|root,COG2366@2|Bacteria,2G63N@200795|Chloroflexi,376RD@32061|Chloroflexia	32061|Chloroflexia	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
CMS3_k127_6912646_1	632518.Calow_0508	2.783e-18	86.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,42GC5@68295|Thermoanaerobacterales	186801|Clostridia	G	ribose 5-phosphate isomerase B	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
CMS3_k127_6922455_3	1121377.KB906410_gene592	4.554e-12	67.0	COG2897@1|root,COG2897@2|Bacteria,1WI0D@1297|Deinococcus-Thermus	2|Bacteria	P	Sulfurtransferase	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
CMS3_k127_6922455_2	634497.HAH_1573	5.088e-38	159.0	COG0477@1|root,arCOG00130@2157|Archaea,2XT6G@28890|Euryarchaeota,23SC5@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_6922455_1	1449353.JQMQ01000004_gene6252	3.296e-44	171.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_6922455_0	391625.PPSIR1_20059	1.177e-45	171.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,42TN9@68525|delta/epsilon subdivisions,2WRG0@28221|Deltaproteobacteria,2Z0S2@29|Myxococcales	28221|Deltaproteobacteria	H	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
CMS3_k127_6923218_1	1298867.AUES01000051_gene4511	4.161e-05	55.0	COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind
CMS3_k127_6929458_1	4113.PGSC0003DMT400089450	2.115e-32	128.0	2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GWDE@35493|Streptophyta,44U28@71274|asterids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6929458_4	1410676.JNKL01000108_gene1988	8.442e-22	98.0	2DMHR@1|root,32RMI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6929458_7	927677.ALVU02000001_gene2649	4.321e-10	62.0	2EK6X@1|root,33DXA@2|Bacteria,1GFHH@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6929458_2	498761.HM1_3148	2.927e-29	119.0	2DN97@1|root,32W7A@2|Bacteria,1VANB@1239|Firmicutes,24Q9J@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6929458_8	702450.CUW_2868	1.375e-07	53.0	2EG09@1|root,339SB@2|Bacteria,1VG42@1239|Firmicutes,3VS8M@526524|Erysipelotrichia	526524|Erysipelotrichia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6929458_5	1382230.ASAP_2763	1.591e-20	96.0	2DPM9@1|root,332MQ@2|Bacteria,1NAPW@1224|Proteobacteria,2UWJH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6929458_0	1128421.JAGA01000002_gene1051	7.51e-39	158.0	COG0037@1|root,COG0037@2|Bacteria,2NPAZ@2323|unclassified Bacteria	2|Bacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	2.4.2.8,6.3.4.19	ko:K00760,ko:K04075	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,Pribosyltran,TilS,TilS_C
CMS3_k127_6929458_9	498761.HM1_0712	9.288e-06	53.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	divIC	-	-	ko:K05589,ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
CMS3_k127_6929458_3	525903.Taci_0911	1.966e-28	127.0	COG0406@1|root,COG0406@2|Bacteria,3TAZ5@508458|Synergistetes	508458|Synergistetes	G	phosphoglycerate mutase family	-	-	3.1.3.3	ko:K22305	ko00260,ko00680,ko01100,ko01120,ko01130,map00260,map00680,map01100,map01120,map01130	-	R00582	RC00017	ko00000,ko00001,ko01000	-	-	-	His_Phos_1
CMS3_k127_6929458_6	255470.cbdbA1388	1.401e-17	89.0	COG5011@1|root,COG5011@2|Bacteria,2G71I@200795|Chloroflexi,34CJ6@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Uncharacterized protein conserved in bacteria (DUF2344)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
CMS3_k127_6935204_0	357808.RoseRS_3858	1.344e-246	786.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2G5ZQ@200795|Chloroflexi,376AA@32061|Chloroflexia	32061|Chloroflexia	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
CMS3_k127_6942644_2	32057.KB217478_gene5493	1.811e-169	542.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria,1HMXM@1161|Nostocales	1117|Cyanobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
CMS3_k127_6942644_5	1123263.AUKY01000055_gene1426	6.212e-05	48.0	COG0607@1|root,COG0607@2|Bacteria,1TUA3@1239|Firmicutes,3VRZR@526524|Erysipelotrichia	526524|Erysipelotrichia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CMS3_k127_6942644_4	525904.Tter_2084	1.068e-10	68.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	-	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	CBS
CMS3_k127_6942644_3	1183438.GKIL_2948	1.728e-85	306.0	COG4191@1|root,COG4191@2|Bacteria,1G1CF@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,cNMP_binding
CMS3_k127_6942644_0	1333998.M2A_2255	6.54e-271	842.0	COG2072@1|root,COG2072@2|Bacteria,1MU71@1224|Proteobacteria,2TV2E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Flavoprotein involved in K transport	MA20_23085	-	-	-	-	-	-	-	-	-	-	-	FMO-like,K_oxygenase,NAD_binding_8,Pyr_redox_2
CMS3_k127_6942644_1	1380390.JIAT01000013_gene145	3.066e-216	716.0	COG0457@1|root,COG2114@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
CMS3_k127_6966653_0	479434.Sthe_1776	1.219e-90	317.0	COG0577@1|root,COG3127@1|root,COG0577@2|Bacteria,COG3127@2|Bacteria,2G6CK@200795|Chloroflexi,27Z42@189775|Thermomicrobia	189775|Thermomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
CMS3_k127_6966653_1	1173026.Glo7428_3738	8.385e-06	50.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1G0XM@1117|Cyanobacteria	1117|Cyanobacteria	E	Glutamate synthase	glsF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
CMS3_k127_6981489_3	1333998.M2A_2493	1.137e-107	362.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,4BTBG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_6981489_0	1205680.CAKO01000037_gene1298	0.0	1332.0	COG0439@1|root,COG1038@1|root,COG4799@1|root,COG0439@2|Bacteria,COG1038@2|Bacteria,COG4799@2|Bacteria,1MU4H@1224|Proteobacteria,2TWYZ@28211|Alphaproteobacteria,2JZ2C@204441|Rhodospirillales	204441|Rhodospirillales	I	Biotin carboxylase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
CMS3_k127_6981489_11	1382306.JNIM01000001_gene2927	1.531e-12	79.0	COG1556@1|root,COG1556@2|Bacteria	2|Bacteria	S	LUD domain	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
CMS3_k127_6981489_1	525904.Tter_2256	1.379e-196	643.0	COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria,2NQQF@2323|unclassified Bacteria	2|Bacteria	C	LUD domain	lutB	-	-	ko:K00782,ko:K18929	-	-	-	-	ko00000	-	-	-	CCG,DUF3390,Fer4_8,LUD_dom
CMS3_k127_6981489_6	1128421.JAGA01000002_gene1930	2.075e-59	223.0	COG0111@1|root,COG0111@2|Bacteria,2NQUW@2323|unclassified Bacteria	2|Bacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS3_k127_6981489_10	644283.Micau_2264	7.331e-20	103.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4D9QY@85008|Micromonosporales	201174|Actinobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_6981489_9	1122247.C731_1921	2.387e-36	152.0	COG3178@1|root,COG3178@2|Bacteria,2GN8T@201174|Actinobacteria,23F8B@1762|Mycobacteriaceae	201174|Actinobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	EcKinase
CMS3_k127_6981489_2	1382306.JNIM01000001_gene2617	3.816e-157	516.0	COG1132@1|root,COG1132@2|Bacteria,2G5QH@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_6981489_8	471853.Bcav_2258	1.209e-52	202.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	MA20_27720	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_6981489_7	103733.JNYO01000080_gene5009	3.439e-56	208.0	COG4221@1|root,COG4221@2|Bacteria,2HA4H@201174|Actinobacteria,4EC3N@85010|Pseudonocardiales	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_6981489_4	1282876.BAOK01000001_gene3210	3.447e-84	299.0	COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2TUVX@28211|Alphaproteobacteria,4BT8D@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
CMS3_k127_6981489_5	1449126.JQKL01000016_gene2873	5.993e-82	287.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia	186801|Clostridia	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_6981489_12	1458357.BG58_41755	9.913e-08	58.0	2E7ZW@1|root,332E8@2|Bacteria,1ND2G@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
CMS3_k127_6991065_1	1144275.COCOR_05741	6.729e-83	295.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,42M9A@68525|delta/epsilon subdivisions,2WJ3Y@28221|Deltaproteobacteria,2YZU4@29|Myxococcales	28221|Deltaproteobacteria	S	Penicillin amidase	-	-	3.5.1.11,3.5.1.97	ko:K01434,ko:K07116	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
CMS3_k127_6991065_0	211114.JOEF01000019_gene646	4.643e-89	303.0	COG1131@1|root,COG1131@2|Bacteria,2GKWB@201174|Actinobacteria,4E8PM@85010|Pseudonocardiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_6995853_16	1382306.JNIM01000001_gene4124	5.467e-42	165.0	COG1560@1|root,COG1560@2|Bacteria	2|Bacteria	M	Kdo2-lipid A biosynthetic process	-	-	2.3.1.241,2.3.1.265	ko:K02517,ko:K22311	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
CMS3_k127_6995853_0	309801.trd_0655	1.856e-183	580.0	COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi,27Y0U@189775|Thermomicrobia	189775|Thermomicrobia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
CMS3_k127_6995853_18	1313172.YM304_33570	6.603e-33	139.0	COG0583@1|root,COG0583@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
CMS3_k127_6995853_21	1459636.NTE_03059	5.073e-13	79.0	arCOG07442@1|root,arCOG07442@2157|Archaea,41SWG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6995853_12	1128421.JAGA01000003_gene3155	4.201e-62	226.0	COG0130@1|root,COG0130@2|Bacteria,2NP9J@2323|unclassified Bacteria	2|Bacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C,TruB_C_2,TruB_N
CMS3_k127_6995853_24	553385.JEMF01000040_gene2222	6.189e-08	64.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1XKKG@135619|Oceanospirillales	135619|Oceanospirillales	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
CMS3_k127_6995853_1	585503.HMPREF7545_0478	2.36e-183	592.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,4H1X3@909932|Negativicutes	909932|Negativicutes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
CMS3_k127_6995853_25	644966.Tmar_1017	2.133e-07	62.0	COG2740@1|root,COG2740@2|Bacteria,1VEJS@1239|Firmicutes,24QSJ@186801|Clostridia,3WCNN@538999|Clostridiales incertae sedis	186801|Clostridia	K	Protein of unknown function (DUF448)	ylxR	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
CMS3_k127_6995853_6	635013.TherJR_1374	7.265e-95	333.0	COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia,2604E@186807|Peptococcaceae	186801|Clostridia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
CMS3_k127_6995853_2	552811.Dehly_0193	4.658e-181	583.0	COG0442@1|root,COG0442@2|Bacteria,2G5Q6@200795|Chloroflexi,34CJ8@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
CMS3_k127_6995853_19	237368.SCABRO_00336	4.006e-26	122.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
CMS3_k127_6995853_3	472759.Nhal_1234	1.31e-154	503.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1WW8H@135613|Chromatiales	135613|Chromatiales	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
CMS3_k127_6995853_7	255470.cbdbA313	1.417e-87	304.0	COG0750@1|root,COG0750@2|Bacteria,2G6HV@200795|Chloroflexi,34D8H@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
CMS3_k127_6995853_5	311424.DhcVS_315	1.408e-102	357.0	COG0743@1|root,COG0743@2|Bacteria,2G5RB@200795|Chloroflexi,34CVA@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
CMS3_k127_6995853_17	1121918.ARWE01000001_gene1934	3.435e-34	142.0	COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,42QTH@68525|delta/epsilon subdivisions,2WQ6V@28221|Deltaproteobacteria,43SXU@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM phosphatidate cytidylyltransferase	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
CMS3_k127_6995853_8	326427.Cagg_0529	1.3e-77	274.0	COG0020@1|root,COG0020@2|Bacteria,2G65C@200795|Chloroflexi,375B7@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
CMS3_k127_6995853_14	1178540.BA70_07045	3.374e-50	187.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,4HFSH@91061|Bacilli,1ZAZF@1386|Bacillus	91061|Bacilli	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
CMS3_k127_6995853_13	309801.trd_0999	8.318e-55	196.0	COG0264@1|root,COG0264@2|Bacteria,2G6MJ@200795|Chloroflexi,27Y81@189775|Thermomicrobia	189775|Thermomicrobia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
CMS3_k127_6995853_10	1125863.JAFN01000001_gene970	2.058e-75	266.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2WJH5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
CMS3_k127_6995853_23	345341.KUTG_04469	2.408e-09	64.0	COG2331@1|root,COG2331@2|Bacteria,2IQHE@201174|Actinobacteria,4E5CR@85010|Pseudonocardiales	201174|Actinobacteria	S	regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
CMS3_k127_6995853_15	498761.HM1_1844	3.877e-45	168.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
CMS3_k127_6995853_22	1996.JOFO01000008_gene3057	1.838e-09	70.0	COG0125@1|root,COG0125@2|Bacteria,2I3EK@201174|Actinobacteria,4EJR1@85012|Streptosporangiales	201174|Actinobacteria	F	Chloramphenicol phosphotransferase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,CPT
CMS3_k127_6995853_9	765420.OSCT_1304	1.493e-75	265.0	COG0157@1|root,COG0157@2|Bacteria,2G6GJ@200795|Chloroflexi,375H1@32061|Chloroflexia	32061|Chloroflexia	H	Belongs to the NadC ModD family	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
CMS3_k127_6995853_4	552811.Dehly_1113	1.569e-116	390.0	COG0029@1|root,COG0029@2|Bacteria,2G5JM@200795|Chloroflexi,34D0E@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CMS3_k127_6995853_20	255470.cbdbA1338	2.672e-22	100.0	COG0029@1|root,COG0029@2|Bacteria,2G5JM@200795|Chloroflexi,34D0E@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CMS3_k127_6995853_11	33905.BTHE_0323	6.044e-64	222.0	COG0379@1|root,COG0379@2|Bacteria,2GM59@201174|Actinobacteria,4D0AI@85004|Bifidobacteriales	201174|Actinobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
CMS3_k127_7020376_8	1380347.JNII01000005_gene3236	4.486e-19	91.0	COG2071@1|root,COG2071@2|Bacteria,2GIV6@201174|Actinobacteria,4EVAD@85013|Frankiales	201174|Actinobacteria	S	Peptidase C26	-	-	4.1.3.27	ko:K01658,ko:K07010	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Peptidase_C26
CMS3_k127_7020376_9	1155714.KB891993_gene5849	1.39e-12	76.0	COG0454@1|root,COG0456@2|Bacteria,2IHRD@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	ypeA	-	2.3.1.1	ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
CMS3_k127_7020376_3	1040986.ATYO01000005_gene6122	4.49e-70	244.0	COG3896@1|root,COG3896@2|Bacteria,1NTZF@1224|Proteobacteria,2UQ7C@28211|Alphaproteobacteria,43PTV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	V	Chloramphenicol phosphotransferase-like protein	-	-	-	ko:K18554	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	CPT
CMS3_k127_7020376_7	195250.CM001776_gene2883	2.246e-19	102.0	COG0265@1|root,COG0265@2|Bacteria,1G0U4@1117|Cyanobacteria,1GYHE@1129|Synechococcus	1117|Cyanobacteria	O	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_7020376_0	469382.Hbor_06670	3.039e-167	544.0	COG2146@1|root,arCOG02852@2157|Archaea,2XUZH@28890|Euryarchaeota,23SZ3@183963|Halobacteria	183963|Halobacteria	P	COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Rieske_2
CMS3_k127_7020376_11	365528.KB891103_gene4075	8.617e-08	57.0	COG0654@1|root,COG0654@2|Bacteria,2I901@201174|Actinobacteria,4EVMP@85013|Frankiales	201174|Actinobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_2,NAD_binding_8,Trp_halogenase
CMS3_k127_7020376_5	118173.KB235914_gene773	1.088e-40	168.0	COG0451@1|root,COG0451@2|Bacteria,1G14S@1117|Cyanobacteria,1H7DX@1150|Oscillatoriales	1117|Cyanobacteria	GM	PFAM NAD dependent epimerase dehydratase family	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
CMS3_k127_7020376_1	196162.Noca_4966	2.943e-163	546.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria	201174|Actinobacteria	F	Drug exporters of the RND superfamily	-	-	-	ko:K06994,ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS3_k127_7020376_2	316274.Haur_0080	6.214e-87	301.0	COG0726@1|root,COG0726@2|Bacteria,2G8CG@200795|Chloroflexi	200795|Chloroflexi	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
CMS3_k127_7020376_6	1123355.JHYO01000020_gene311	4.228e-26	118.0	COG3911@1|root,COG3911@2|Bacteria,1RD7P@1224|Proteobacteria,2U76H@28211|Alphaproteobacteria,36YVX@31993|Methylocystaceae	28211|Alphaproteobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_28
CMS3_k127_7020376_4	926564.KI911653_gene1474	1.801e-57	214.0	COG3591@1|root,COG3591@2|Bacteria,2GJVS@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the glycosyl hydrolase 3 family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7020376_10	1033802.SSPSH_000200	9.672e-11	64.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RPQC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_7039138_0	765420.OSCT_0522	4.587e-83	289.0	COG4143@1|root,COG4143@2|Bacteria,2G615@200795|Chloroflexi,376Q5@32061|Chloroflexia	32061|Chloroflexia	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
CMS3_k127_7039138_1	1128421.JAGA01000002_gene569	1.735e-70	257.0	COG1178@1|root,COG1178@2|Bacteria	2|Bacteria	P	thiamine transport	thiP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015234,GO:0015238,GO:0015893,GO:0016020,GO:0022857,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0045117,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071934,GO:0071944,GO:0072348,GO:0072531,GO:0090482,GO:1901474,GO:1901682	-	ko:K02063	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	iAPECO1_1312.APECO1_1915,iECIAI1_1343.ECIAI1_0067,iECO103_1326.ECO103_0068,iECO111_1330.ECO111_0069,iECO26_1355.ECO26_0069,iECOK1_1307.ECOK1_0068,iECS88_1305.ECS88_0072,iECSE_1348.ECSE_0067,iECUMN_1333.ECUMN_0068,iPC815.YPO0521,iSF_1195.SF0062,iSFxv_1172.SFxv_0064,iS_1188.S0064,iUMN146_1321.UM146_23130,iUTI89_1310.UTI89_C0075	BPD_transp_1
CMS3_k127_7039686_30	1313172.YM304_11550	5.742e-30	128.0	COG2035@1|root,COG2035@2|Bacteria,2I8HU@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	ko:K08974	-	-	-	-	ko00000	-	-	-	DUF368
CMS3_k127_7039686_13	101510.RHA1_ro11036	6.168e-82	288.0	COG1028@1|root,COG1028@2|Bacteria,2GIRG@201174|Actinobacteria,4FU04@85025|Nocardiaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
CMS3_k127_7039686_22	1120950.KB892708_gene4411	1.806e-54	202.0	COG1938@1|root,COG1938@2|Bacteria,2GK10@201174|Actinobacteria,4DNMH@85009|Propionibacteriales	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
CMS3_k127_7039686_23	552811.Dehly_0243	3.359e-54	199.0	COG0062@1|root,COG0062@2|Bacteria,2G8T6@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX	-	-	5.1.99.6	ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	YjeF_N
CMS3_k127_7039686_9	1382356.JQMP01000004_gene561	4.032e-94	319.0	COG2141@1|root,COG2141@2|Bacteria,2G87P@200795|Chloroflexi,27XPZ@189775|Thermomicrobia	189775|Thermomicrobia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_7039686_31	485913.Krac_3076	1.634e-28	123.0	COG1670@1|root,COG1670@2|Bacteria,2G76C@200795|Chloroflexi	200795|Chloroflexi	J	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
CMS3_k127_7039686_25	1157708.KB907457_gene2794	4.93e-40	165.0	COG1247@1|root,COG1247@2|Bacteria,1R6UW@1224|Proteobacteria,2W2QC@28216|Betaproteobacteria,4AHQC@80864|Comamonadaceae	28216|Betaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_7039686_7	1313172.YM304_32630	1.257e-98	329.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
CMS3_k127_7039686_38	1121382.JQKG01000022_gene1433	5.834e-17	91.0	COG0785@1|root,COG0785@2|Bacteria,1WJ3U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	PFAM cytochrome c biogenesis protein, transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
CMS3_k127_7039686_34	710696.Intca_1875	8.896e-25	114.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria,4FJ07@85021|Intrasporangiaceae	201174|Actinobacteria	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,DsbD
CMS3_k127_7039686_6	926550.CLDAP_34700	3.477e-105	357.0	COG2008@1|root,COG2008@2|Bacteria,2G5XG@200795|Chloroflexi	200795|Chloroflexi	E	aromatic amino acid beta-eliminating lyase threonine aldolase	gly1	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
CMS3_k127_7039686_18	1150864.MILUP08_41743	1.478e-66	243.0	COG1136@1|root,COG1136@2|Bacteria,2GJQV@201174|Actinobacteria,4D9QK@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_7039686_10	1122919.KB905550_gene1950	5.564e-91	308.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,4HC59@91061|Bacilli,26SC2@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_7039686_29	263358.VAB18032_20545	1.99e-30	141.0	COG0577@1|root,COG0577@2|Bacteria,2H997@201174|Actinobacteria,4DBGI@85008|Micromonosporales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
CMS3_k127_7039686_1	309801.trd_0700	2.094e-241	778.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2G5J0@200795|Chloroflexi,27Y2S@189775|Thermomicrobia	189775|Thermomicrobia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
CMS3_k127_7039686_19	316274.Haur_1194	1.14e-60	219.0	COG0266@1|root,COG0266@2|Bacteria,2G6BB@200795|Chloroflexi,376AI@32061|Chloroflexia	32061|Chloroflexia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
CMS3_k127_7039686_37	1278073.MYSTI_02730	4.909e-19	98.0	COG1073@1|root,COG1073@2|Bacteria,1MY4C@1224|Proteobacteria,42TB9@68525|delta/epsilon subdivisions,2WXEF@28221|Deltaproteobacteria,2YW3Y@29|Myxococcales	28221|Deltaproteobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
CMS3_k127_7039686_12	1089548.KI783301_gene1947	5.383e-88	301.0	COG3191@1|root,COG3191@2|Bacteria,1TP60@1239|Firmicutes,4HD7F@91061|Bacilli	91061|Bacilli	EQ	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
CMS3_k127_7039686_11	246194.CHY_2377	1.699e-90	309.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,42FEE@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
CMS3_k127_7039686_8	1128421.JAGA01000002_gene351	8.889e-97	324.0	COG0414@1|root,COG0414@2|Bacteria,2NP0J@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
CMS3_k127_7039686_14	311424.DhcVS_386	7.398e-75	260.0	COG0217@1|root,COG0217@2|Bacteria,2G6AI@200795|Chloroflexi,34CQY@301297|Dehalococcoidia	301297|Dehalococcoidia	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
CMS3_k127_7039686_26	926550.CLDAP_12560	3.184e-35	140.0	COG0817@1|root,COG0817@2|Bacteria,2G6MA@200795|Chloroflexi	200795|Chloroflexi	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
CMS3_k127_7039686_28	933262.AXAM01000015_gene86	1.687e-30	132.0	COG0632@1|root,COG0632@2|Bacteria,1Q5HB@1224|Proteobacteria,42R4Y@68525|delta/epsilon subdivisions,2WMRB@28221|Deltaproteobacteria,2MJPI@213118|Desulfobacterales	28221|Deltaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_N
CMS3_k127_7039686_0	479434.Sthe_0796	3.263e-298	929.0	COG0556@1|root,COG0556@2|Bacteria,2G5SU@200795|Chloroflexi,27XME@189775|Thermomicrobia	189775|Thermomicrobia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
CMS3_k127_7039686_3	552811.Dehly_0150	1.06e-158	531.0	COG1674@1|root,COG1674@2|Bacteria,2G5XC@200795|Chloroflexi,34CZW@301297|Dehalococcoidia	301297|Dehalococcoidia	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE,Ftsk_gamma
CMS3_k127_7039686_2	255470.cbdbA392	2.959e-187	602.0	COG0595@1|root,COG0595@2|Bacteria,2G611@200795|Chloroflexi,34CSJ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
CMS3_k127_7039686_21	479434.Sthe_0942	7.492e-59	215.0	COG1573@1|root,COG1573@2|Bacteria,2G6BR@200795|Chloroflexi,27XM8@189775|Thermomicrobia	189775|Thermomicrobia	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS3_k127_7039686_24	326427.Cagg_0210	6.612e-46	175.0	COG0805@1|root,COG0805@2|Bacteria,2G6SP@200795|Chloroflexi,375NQ@32061|Chloroflexia	32061|Chloroflexia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
CMS3_k127_7039686_44	436114.SYO3AOP1_1474	2.778e-06	56.0	COG1826@1|root,COG1826@2|Bacteria,2G4BU@200783|Aquificae	200783|Aquificae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	-	-	-	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
CMS3_k127_7039686_35	552811.Dehly_0305	4.493e-24	104.0	COG0236@1|root,COG0236@2|Bacteria,2G76M@200795|Chloroflexi,34DGE@301297|Dehalococcoidia	301297|Dehalococcoidia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CMS3_k127_7039686_33	1382356.JQMP01000003_gene1311	2.108e-28	130.0	COG0781@1|root,COG0781@2|Bacteria,2G6XA@200795|Chloroflexi,27YFI@189775|Thermomicrobia	189775|Thermomicrobia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
CMS3_k127_7039686_15	867845.KI911784_gene3538	1.47e-74	267.0	COG1028@1|root,COG1028@2|Bacteria,2G5KB@200795|Chloroflexi,3759E@32061|Chloroflexia	32061|Chloroflexia	IQ	short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_7039686_16	717605.Theco_2138	1.583e-74	262.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4HBCU@91061|Bacilli,26QJX@186822|Paenibacillaceae	91061|Bacilli	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
CMS3_k127_7039686_42	997346.HMPREF9374_0901	4.933e-13	70.0	COG0333@1|root,COG0333@2|Bacteria,1VEFI@1239|Firmicutes,4HNIZ@91061|Bacilli,27D5Q@186824|Thermoactinomycetaceae	91061|Bacilli	J	Ribosomal L32p protein family	rpmF	GO:0003674,GO:0003735,GO:0005198	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
CMS3_k127_7039686_32	1382306.JNIM01000001_gene3739	1.689e-28	122.0	COG1399@1|root,COG1399@2|Bacteria,2G6Z5@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
CMS3_k127_7039686_36	243164.DET0155	8.537e-23	113.0	COG1961@1|root,COG1961@2|Bacteria,2G7BH@200795|Chloroflexi,34DMJ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
CMS3_k127_7039686_27	457429.ABJI02000129_gene2782	1.222e-30	131.0	COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria	201174|Actinobacteria	P	ABC transporter, periplasmic molybdate-binding protein	modA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
CMS3_k127_7039686_20	1254432.SCE1572_08275	8.99e-60	218.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,42PIX@68525|delta/epsilon subdivisions,2WJRF@28221|Deltaproteobacteria,2Z3J9@29|Myxococcales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02018,ko:K02046,ko:K15496	ko00920,ko02010,map00920,map02010	M00185,M00189,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.6.5,3.A.1.8	-	-	BPD_transp_1
CMS3_k127_7039686_17	926550.CLDAP_05980	2.641e-67	246.0	COG3842@1|root,COG3842@2|Bacteria,2G6S3@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE_2
CMS3_k127_7039686_40	1283299.AUKG01000001_gene3439	3.082e-14	83.0	COG3871@1|root,COG3871@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_7039686_5	1382306.JNIM01000001_gene2552	3.104e-113	386.0	COG0769@1|root,COG0769@2|Bacteria,2G5U3@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS3_k127_7039686_4	357808.RoseRS_0404	2.367e-123	407.0	COG0161@1|root,COG0161@2|Bacteria,2G62N@200795|Chloroflexi,376DU@32061|Chloroflexia	32061|Chloroflexia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
CMS3_k127_7042539_2	235985.BBPN01000004_gene3040	4.753e-13	78.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,2NF93@228398|Streptacidiphilus	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_7042539_1	247490.KSU1_B0031	2.52e-34	142.0	COG0347@1|root,COG0347@2|Bacteria,2J0NT@203682|Planctomycetes	203682|Planctomycetes	K	Nitrogen regulatory protein P-II	-	-	-	-	-	-	-	-	-	-	-	-	P-II
CMS3_k127_7042539_0	1521187.JPIM01000039_gene481	5.843e-133	441.0	COG0004@1|root,COG0004@2|Bacteria,2G5N8@200795|Chloroflexi,3753U@32061|Chloroflexia	32061|Chloroflexia	P	PFAM Rh family protein ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
CMS3_k127_7079427_0	631454.N177_1475	3.303e-10	64.0	COG4770@1|root,COG4770@2|Bacteria,1PU81@1224|Proteobacteria,2VCYP@28211|Alphaproteobacteria,1JQK3@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
CMS3_k127_7086889_1	367299.JOEE01000004_gene1056	1.831e-139	448.0	COG1741@1|root,COG1741@2|Bacteria,2GIY9@201174|Actinobacteria,4FG5R@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
CMS3_k127_7086889_6	682795.AciX8_3740	5.088e-93	325.0	COG2124@1|root,COG2124@2|Bacteria,3Y4Y2@57723|Acidobacteria,2JMFM@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
CMS3_k127_7086889_2	1313172.YM304_36000	9.169e-113	376.0	COG3752@1|root,COG3752@2|Bacteria,2GNX1@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
CMS3_k127_7086889_3	1380394.JADL01000013_gene704	1.153e-110	368.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSMN@28211|Alphaproteobacteria,2JVSH@204441|Rhodospirillales	204441|Rhodospirillales	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS3_k127_7086889_4	1096546.WYO_5033	3.681e-110	396.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,1JTBT@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	NADP oxidoreductase coenzyme F420-dependent	MA20_25935	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
CMS3_k127_7086889_0	1123229.AUBC01000003_gene2054	2.661e-306	971.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2TS9R@28211|Alphaproteobacteria,3JQN2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	GO:0000287,GO:0003674,GO:0003824,GO:0004474,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0016054,GO:0016740,GO:0016746,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046395,GO:0046487,GO:0046872,GO:0046912,GO:0071704,GO:0072329,GO:1901575	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
CMS3_k127_7086889_7	1305737.JAFX01000001_gene2017	1.301e-75	280.0	COG2055@1|root,COG2055@2|Bacteria,4NGVC@976|Bacteroidetes,47KBZ@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
CMS3_k127_7086889_5	279714.FuraDRAFT_3654	5.813e-109	377.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9
CMS3_k127_7097588_1	479434.Sthe_3385	1.279e-107	361.0	COG1062@1|root,COG1062@2|Bacteria,2G7KZ@200795|Chloroflexi,27XUS@189775|Thermomicrobia	189775|Thermomicrobia	C	Zinc-binding dehydrogenase	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_7097588_2	471853.Bcav_2761	1.976e-71	250.0	COG0454@1|root,COG0454@2|Bacteria	2|Bacteria	K	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_6
CMS3_k127_7097588_0	479434.Sthe_0227	0.0	1140.0	COG0587@1|root,COG0587@2|Bacteria,2G811@200795|Chloroflexi,27Z3J@189775|Thermomicrobia	189775|Thermomicrobia	L	Belongs to the DNA polymerase type-C family. DnaE2 subfamily	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
CMS3_k127_7097588_4	552811.Dehly_0427	1.294e-06	61.0	29U2R@1|root,30FC1@2|Bacteria,2G9M3@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7097588_3	479434.Sthe_2045	3.539e-70	254.0	COG0389@1|root,COG0389@2|Bacteria	2|Bacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	imuB	-	2.7.7.7	ko:K02346,ko:K14161	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS
CMS3_k127_7128963_0	196162.Noca_1184	5.619e-44	178.0	COG3848@1|root,COG3848@2|Bacteria,2I3FP@201174|Actinobacteria,4DVNT@85009|Propionibacteriales	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
CMS3_k127_7128963_1	1160137.KB907307_gene2819	3.983e-34	142.0	COG1028@1|root,COG1028@2|Bacteria,2GIRG@201174|Actinobacteria,4FY81@85025|Nocardiaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
CMS3_k127_7171278_2	502025.Hoch_6370	2.471e-35	145.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	intA	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
CMS3_k127_7171278_0	237368.SCABRO_00954	6.446e-140	461.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
CMS3_k127_7171278_5	378806.STAUR_2607	1.217e-05	55.0	2BTCX@1|root,32NIP@2|Bacteria,1Q3TV@1224|Proteobacteria,43431@68525|delta/epsilon subdivisions,2X4Z1@28221|Deltaproteobacteria,2Z09M@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7171278_3	502025.Hoch_2880	1.198e-22	99.0	2BTCX@1|root,32NIP@2|Bacteria,1Q3TV@1224|Proteobacteria,43431@68525|delta/epsilon subdivisions,2X4Z1@28221|Deltaproteobacteria,2Z09M@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7171278_1	378806.STAUR_2499	2.472e-42	159.0	COG3628@1|root,COG3628@2|Bacteria,1QA42@1224|Proteobacteria,434TY@68525|delta/epsilon subdivisions,2WZ4W@28221|Deltaproteobacteria,2Z1C5@29|Myxococcales	28221|Deltaproteobacteria	S	GPW Gp25 family protein	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
CMS3_k127_7171278_4	1242864.D187_004247	5.606e-06	59.0	COG4223@1|root,COG4223@2|Bacteria,1Q3K9@1224|Proteobacteria,439D9@68525|delta/epsilon subdivisions,2X4N1@28221|Deltaproteobacteria,2YZA1@29|Myxococcales	28221|Deltaproteobacteria	S	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH	-	-	-	-	-	-	-	-	-	-	-	-	AHH
CMS3_k127_7173829_3	1131553.JIBI01000026_gene62	1.725e-28	124.0	COG2267@1|root,COG2267@2|Bacteria,1QXHW@1224|Proteobacteria,2W9K4@28216|Betaproteobacteria,372K0@32003|Nitrosomonadales	28216|Betaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
CMS3_k127_7173829_0	298653.Franean1_5399	2.37e-150	490.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4EUTF@85013|Frankiales	201174|Actinobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
CMS3_k127_7173829_1	1169161.KB897716_gene5818	6.366e-47	181.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_7173829_2	266117.Rxyl_0159	1.717e-31	142.0	COG4585@1|root,COG4585@2|Bacteria,2GJKG@201174|Actinobacteria,4CQ9Z@84995|Rubrobacteria	84995|Rubrobacteria	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
CMS3_k127_7173829_4	1121123.AUAO01000003_gene2520	2.747e-05	55.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,2KFQK@204458|Caulobacterales	204458|Caulobacterales	KQ	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,Methyltransf_11
CMS3_k127_7173829_5	1476583.DEIPH_ctg017orf0199	6.142e-05	47.0	COG0558@1|root,COG0558@2|Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	ynbA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS3_k127_7220672_0	1108045.GORHZ_060_00170	3.175e-65	237.0	COG2197@1|root,COG2197@2|Bacteria,2I9YV@201174|Actinobacteria,4GGYC@85026|Gordoniaceae	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
CMS3_k127_7220672_2	1502851.FG93_03414	5.084e-19	91.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	bacB	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016860,GO:0016863,GO:0016999,GO:0017000,GO:0017144,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0046872,GO:0046914,GO:0050897	5.3.3.19	ko:K19547	ko01130,map01130	M00787	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	CDO_I,Cupin_2
CMS3_k127_7220672_1	2074.JNYD01000010_gene1031	5.47e-29	128.0	COG0596@1|root,COG0596@2|Bacteria,2IKJJ@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_7292698_1	1206732.BAGD01000054_gene1961	5.443e-86	301.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4FWX1@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_7292698_0	1246626.BleG1_0541	1.334e-117	393.0	COG1228@1|root,COG1228@2|Bacteria,1TQQ0@1239|Firmicutes,4HDKW@91061|Bacilli,1ZE8W@1386|Bacillus	91061|Bacilli	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_7419409_0	1096546.WYO_2176	8.96e-68	246.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,1JTCM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_7419409_1	1380394.JADL01000001_gene2170	1.139e-28	122.0	COG0346@1|root,COG0346@2|Bacteria,1NFR3@1224|Proteobacteria,2UMIM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_7421746_0	316274.Haur_4439	3.443e-126	417.0	COG0473@1|root,COG0473@2|Bacteria,2G63C@200795|Chloroflexi,3755M@32061|Chloroflexia	32061|Chloroflexia	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CMS3_k127_7421746_1	483219.LILAB_08240	1.605e-13	80.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	aph	-	-	-	-	-	-	-	-	-	-	-	APH
CMS3_k127_7574704_1	35754.JNYJ01000043_gene4438	7.651e-53	197.0	COG0671@1|root,COG0671@2|Bacteria,2GMYU@201174|Actinobacteria,4DIVE@85008|Micromonosporales	201174|Actinobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
CMS3_k127_7574704_0	331869.BAL199_27206	7.071e-88	298.0	COG0412@1|root,COG0412@2|Bacteria,1R9JT@1224|Proteobacteria,2U4J1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	DLH
CMS3_k127_7574704_2	1306990.BARG01000086_gene8534	7.956e-19	93.0	2E8T5@1|root,3333Y@2|Bacteria,2IS1D@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7574704_3	652103.Rpdx1_3329	9.872e-16	88.0	COG2030@1|root,COG2030@2|Bacteria,1NYEM@1224|Proteobacteria,2U0F4@28211|Alphaproteobacteria,3JVIY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	dehydratase	MA20_27475	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_761662_1	868864.Dester_1175	1.363e-105	351.0	COG0136@1|root,COG0136@2|Bacteria,2G3QW@200783|Aquificae	200783|Aquificae	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
CMS3_k127_761662_2	255470.cbdbA935	2.049e-75	273.0	COG0329@1|root,COG0329@2|Bacteria,2G6U3@200795|Chloroflexi,34CY7@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CMS3_k127_761662_3	326424.FRAAL5014	1.181e-23	111.0	2ESDY@1|root,33JYM@2|Bacteria,2IM4G@201174|Actinobacteria	201174|Actinobacteria	S	Aminoglycoside-2''-adenylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminoglyc_resit
CMS3_k127_761662_4	1123368.AUIS01000004_gene272	1.452e-19	100.0	COG3663@1|root,COG3663@2|Bacteria,1RAVZ@1224|Proteobacteria,1S2GN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells	mug	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS3_k127_761662_0	1123309.AQYB01000030_gene1832	3.207e-144	469.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,4H9YT@91061|Bacilli	91061|Bacilli	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
CMS3_k127_7626133_0	255470.cbdbA512	1.052e-90	316.0	COG1484@1|root,COG1484@2|Bacteria,2G65F@200795|Chloroflexi,34CQC@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Bacterial dnaA  protein	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
CMS3_k127_768754_1	525904.Tter_0955	6.149e-42	164.0	COG0061@1|root,COG0061@2|Bacteria,2NP7T@2323|unclassified Bacteria	2|Bacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
CMS3_k127_768754_0	485913.Krac_0006	1.637e-174	557.0	COG1219@1|root,COG1219@2|Bacteria,2G661@200795|Chloroflexi	200795|Chloroflexi	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
CMS3_k127_768754_2	138119.DSY3354	3.748e-15	76.0	COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,247QY@186801|Clostridia,260UI@186807|Peptococcaceae	186801|Clostridia	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
CMS3_k127_793942_2	479434.Sthe_0100	2.635e-99	333.0	COG2141@1|root,COG2141@2|Bacteria,2GB6V@200795|Chloroflexi,27XHN@189775|Thermomicrobia	189775|Thermomicrobia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_793942_4	358681.BBR47_22720	3.274e-08	62.0	COG4454@1|root,COG4454@2|Bacteria,1V23W@1239|Firmicutes,4HGGT@91061|Bacilli,2717N@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
CMS3_k127_793942_3	877455.Metbo_0129	1.306e-63	224.0	COG2818@1|root,arCOG06523@2157|Archaea,2XYHS@28890|Euryarchaeota,23PMP@183925|Methanobacteria	183925|Methanobacteria	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
CMS3_k127_793942_1	588596.U9T1R7	1.096e-99	339.0	COG1473@1|root,2QQPD@2759|Eukaryota,38CZV@33154|Opisthokonta,3NUFT@4751|Fungi	4751|Fungi	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_793942_0	867845.KI911784_gene3323	0.0	1140.0	COG1048@1|root,COG1048@2|Bacteria,2G5NG@200795|Chloroflexi,374T1@32061|Chloroflexia	32061|Chloroflexia	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
CMS3_k127_82983_3	1121405.dsmv_0160	7.04e-09	64.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,42RZK@68525|delta/epsilon subdivisions,2WQ3C@28221|Deltaproteobacteria,2MKAT@213118|Desulfobacterales	28221|Deltaproteobacteria	H	molybdopterin-guanine dinucleotide biosynthesis protein	-	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
CMS3_k127_82983_2	670487.Ocepr_0936	4.103e-18	98.0	COG1254@1|root,COG1254@2|Bacteria,1WK7T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Belongs to the acylphosphatase family	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
CMS3_k127_82983_0	1382306.JNIM01000001_gene1342	1.281e-120	408.0	COG0337@1|root,COG0337@2|Bacteria,2G5K8@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
CMS3_k127_82983_1	1120958.AULD01000016_gene1279	2.739e-67	237.0	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4FMBD@85023|Microbacteriaceae	201174|Actinobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2540c	Chorismate_synt
CMS3_k127_8344_1	926550.CLDAP_07190	8.993e-52	195.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	nosY	-	-	ko:K19341	ko02010,map02010	M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.132.2	-	-	ABC2_membrane_2
CMS3_k127_8344_0	479434.Sthe_0737	6.121e-164	541.0	COG1131@1|root,COG3420@1|root,COG1131@2|Bacteria,COG3420@2|Bacteria,2G7PN@200795|Chloroflexi,27Z0E@189775|Thermomicrobia	189775|Thermomicrobia	P	Domain present in carbohydrate binding proteins and sugar hydrolses	-	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	ABC_tran,NosD
CMS3_k127_8344_2	518766.Rmar_2013	2.471e-05	48.0	COG4314@1|root,COG4314@2|Bacteria,4NIPU@976|Bacteroidetes,1FJJY@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	lipoprotein involved in nitrous oxide reduction	-	-	-	ko:K19342	-	-	-	-	ko00000	-	-	-	NosL
CMS3_k127_868530_2	1463853.JOHW01000004_gene2393	1.809e-27	114.0	COG4274@1|root,COG4274@2|Bacteria,2IJ0R@201174|Actinobacteria	201174|Actinobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
CMS3_k127_868530_1	768671.ThimaDRAFT_4622	3.7e-51	203.0	COG2128@1|root,COG2128@2|Bacteria,1N82C@1224|Proteobacteria,1RQQI@1236|Gammaproteobacteria,1X0YI@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF3179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3179
CMS3_k127_868530_0	370438.PTH_0557	9.076e-62	228.0	COG0644@1|root,COG0644@2|Bacteria,1TRTQ@1239|Firmicutes,24E1W@186801|Clostridia,261F2@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM geranylgeranyl reductase family	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Lycopene_cycl
CMS3_k127_93102_22	1463934.JOCF01000061_gene3265	1.363e-08	59.0	COG0596@1|root,COG0596@2|Bacteria,2IAKH@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_93102_15	880070.Cycma_2067	9.831e-40	160.0	COG3836@1|root,COG3836@2|Bacteria,4NJ5Y@976|Bacteroidetes,47NC8@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
CMS3_k127_93102_2	479434.Sthe_0989	2.013e-134	451.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2G5Q5@200795|Chloroflexi,27Y10@189775|Thermomicrobia	189775|Thermomicrobia	EU	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS3_k127_93102_19	661478.OP10G_3097	2.663e-20	103.0	COG2833@1|root,COG2833@2|Bacteria	2|Bacteria	I	Protein of unknown function (DUF455)	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF455
CMS3_k127_93102_23	598467.BrE312_0078	1.008e-06	61.0	COG0167@1|root,COG1146@1|root,COG0167@2|Bacteria,COG1146@2|Bacteria,1MXER@1224|Proteobacteria,1RRTA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CF	catalyzes the conversion of	preA	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0006139,GO:0006206,GO:0006208,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016651,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0048037,GO:0051536,GO:0051540,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_2293	DHO_dh,Fer4_21
CMS3_k127_93102_24	1122919.KB905563_gene2528	0.0008765	51.0	COG2833@1|root,COG2833@2|Bacteria,1W5BJ@1239|Firmicutes,4I0UF@91061|Bacilli,26VKN@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF455
CMS3_k127_93102_14	84531.JMTZ01000094_gene649	6.362e-40	166.0	COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,1RZRK@1236|Gammaproteobacteria,1X4X1@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_93102_4	1333998.M2A_2493	1.062e-112	383.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,4BTBG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_93102_7	1218084.BBJK01000094_gene6113	2.844e-69	246.0	COG4221@1|root,COG4221@2|Bacteria,1QVS5@1224|Proteobacteria,2WETH@28216|Betaproteobacteria,1KHVB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_93102_21	1206741.BAFX01000098_gene4501	6.362e-11	76.0	COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria,4FZFP@85025|Nocardiaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_93102_10	1297617.JPJD01000007_gene68	8.424e-68	243.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,268J5@186813|unclassified Clostridiales	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	oppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS3_k127_93102_9	266264.Rmet_4577	2.38e-68	243.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2W02P@28216|Betaproteobacteria,1KDF1@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
CMS3_k127_93102_20	649754.HMPREF0281_00587	1.117e-11	78.0	COG4166@1|root,COG4166@2|Bacteria,2GIUH@201174|Actinobacteria,22K1U@1653|Corynebacteriaceae	201174|Actinobacteria	E	ABC transporter substrate-binding protein	dppA	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
CMS3_k127_93102_11	1297617.JPJD01000007_gene68	1.032e-67	243.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,268J5@186813|unclassified Clostridiales	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	oppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS3_k127_93102_12	1380387.JADM01000003_gene2658	2.046e-65	237.0	COG1173@1|root,COG1173@2|Bacteria,1MVHY@1224|Proteobacteria,1RR5Y@1236|Gammaproteobacteria,1XNJ2@135619|Oceanospirillales	135619|Oceanospirillales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS3_k127_93102_18	1280953.HOC_13119	8.884e-30	132.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529,ko:K03604	-	-	-	-	ko00000,ko03000	-	-	-	GntR,HTH_18,LacI,Peripla_BP_1,Peripla_BP_3
CMS3_k127_93102_13	1469245.JFBG01000008_gene751	3.224e-53	197.0	COG0778@1|root,COG0778@2|Bacteria,1NCBD@1224|Proteobacteria,1SVTW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS3_k127_93102_0	479434.Sthe_1801	4.039e-158	510.0	COG0001@1|root,COG0001@2|Bacteria,2G67D@200795|Chloroflexi,27Y34@189775|Thermomicrobia	189775|Thermomicrobia	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_93102_1	1382356.JQMP01000001_gene828	2.861e-136	441.0	COG0113@1|root,COG0113@2|Bacteria,2G5QT@200795|Chloroflexi,27XTX@189775|Thermomicrobia	189775|Thermomicrobia	H	Delta-aminolevulinic acid dehydratase	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
CMS3_k127_93102_3	1128421.JAGA01000001_gene2427	8.058e-131	440.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2NPBQ@2323|unclassified Bacteria	2|Bacteria	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	hemD	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.107,2.5.1.61,4.2.1.75	ko:K01719,ko:K01749,ko:K02303,ko:K13542,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084,R03165,R03194	RC00003,RC00871,RC01861,RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15755,iJN678.hemD	HEM4,TP_methylase
CMS3_k127_93102_6	1382356.JQMP01000001_gene830	3.863e-72	254.0	COG0181@1|root,COG0181@2|Bacteria,2G6JU@200795|Chloroflexi,27Y7G@189775|Thermomicrobia	189775|Thermomicrobia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	-	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
CMS3_k127_93102_8	644966.Tmar_1263	2.876e-69	254.0	COG0373@1|root,COG0373@2|Bacteria,1TQN9@1239|Firmicutes,2496M@186801|Clostridia,3WDC1@538999|Clostridiales incertae sedis	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
CMS3_k127_93102_16	278963.ATWD01000002_gene406	2.713e-39	155.0	COG1648@1|root,COG1648@2|Bacteria,3Y4XH@57723|Acidobacteria,2JJKI@204432|Acidobacteriia	204432|Acidobacteriia	H	Sirohaem biosynthesis protein central	-	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
CMS3_k127_93102_17	243233.MCA1802	1.963e-37	159.0	COG1670@1|root,COG1670@2|Bacteria,1RB1I@1224|Proteobacteria,1S7ZE@1236|Gammaproteobacteria,1XGDV@135618|Methylococcales	135618|Methylococcales	J	Domain of unknown function (DUF4202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4202
CMS3_k127_93102_5	1380390.JIAT01000009_gene2153	2.599e-87	305.0	COG0155@1|root,COG0155@2|Bacteria,2GJRN@201174|Actinobacteria,4CQKT@84995|Rubrobacteria	84995|Rubrobacteria	C	Nitrite and sulphite reductase 4Fe-4S domain	-	-	1.7.7.1,1.8.1.2	ko:K00366,ko:K00381	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00858	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
CMS3_k127_952713_0	1205680.CAKO01000007_gene4412	3.234e-59	219.0	COG2141@1|root,COG2141@2|Bacteria,1NX0H@1224|Proteobacteria,2U42F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_952713_1	1120972.AUMH01000006_gene1809	7.661e-53	202.0	COG0657@1|root,COG0657@2|Bacteria,1UWRG@1239|Firmicutes,4I9QW@91061|Bacilli,27AB6@186823|Alicyclobacillaceae	91061|Bacilli	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
CMS3_k127_952713_2	441620.Mpop_3017	8.529e-19	92.0	COG0346@1|root,COG0346@2|Bacteria,1RH3J@1224|Proteobacteria,2U9J3@28211|Alphaproteobacteria,1JUXB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_955393_0	1410634.JHVD01000027_gene1655	4.127e-140	464.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4DPNE@85009|Propionibacteriales	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS
CMS3_k127_955393_1	472759.Nhal_2851	1.263e-137	452.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales	135613|Chromatiales	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_955393_4	1437606.BBOH_0281	2.29e-10	68.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CZ24@85004|Bifidobacteriales	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS
CMS3_k127_955393_2	1038860.AXAP01000157_gene8657	4.119e-24	114.0	COG2801@1|root,COG2801@2|Bacteria,1MX69@1224|Proteobacteria,2TSIE@28211|Alphaproteobacteria,3K2DN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
CMS3_k127_955393_3	909613.UO65_6191	4.559e-18	90.0	COG5516@1|root,COG5516@2|Bacteria,2IFNZ@201174|Actinobacteria,4E4QJ@85010|Pseudonocardiales	201174|Actinobacteria	S	CGNR zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
CMS3_k127_959308_3	234267.Acid_5780	2.546e-158	525.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,TPR_8,Trans_reg_C
CMS3_k127_959308_12	1123399.AQVE01000001_gene694	1.119e-80	291.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,1S3ER@1236|Gammaproteobacteria,463H3@72273|Thiotrichales	72273|Thiotrichales	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_959308_10	926560.KE387023_gene2289	3.216e-103	352.0	COG3852@1|root,COG3852@2|Bacteria,1WMD2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
CMS3_k127_959308_1	926560.KE387023_gene1698	9.415e-192	615.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1WM1W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	KOT	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Response_reg
CMS3_k127_959308_17	1313172.YM304_17800	9.908e-34	141.0	COG2353@1|root,COG2353@2|Bacteria,2IM4N@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
CMS3_k127_959308_22	1121938.AUDY01000007_gene2501	2.259e-05	49.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_959308_11	479434.Sthe_2430	9.793e-97	332.0	COG1173@1|root,COG1173@2|Bacteria,2G6HB@200795|Chloroflexi,27XKI@189775|Thermomicrobia	189775|Thermomicrobia	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
CMS3_k127_959308_5	479434.Sthe_2431	3.546e-135	437.0	COG0601@1|root,COG0601@2|Bacteria,2G7SK@200795|Chloroflexi,27XXY@189775|Thermomicrobia	189775|Thermomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS3_k127_959308_0	479434.Sthe_2432	1.362e-198	635.0	COG0747@1|root,COG0747@2|Bacteria,2G860@200795|Chloroflexi,27XM9@189775|Thermomicrobia	189775|Thermomicrobia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_959308_7	1122614.JHZF01000001_gene357	7.83e-112	372.0	COG3958@1|root,COG3958@2|Bacteria,1N6QF@1224|Proteobacteria,2TTU8@28211|Alphaproteobacteria,2PENX@252301|Oceanicola	28211|Alphaproteobacteria	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS3_k127_959308_8	1089544.KB912942_gene2678	1.59e-108	358.0	COG3959@1|root,COG3959@2|Bacteria,2GJ6M@201174|Actinobacteria,4DYR6@85010|Pseudonocardiales	201174|Actinobacteria	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
CMS3_k127_959308_19	1077974.GOEFS_015_00560	2.646e-09	67.0	COG1309@1|root,COG1309@2|Bacteria,2GP59@201174|Actinobacteria,4GFWK@85026|Gordoniaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
CMS3_k127_959308_6	1122611.KB903945_gene1394	4.963e-126	415.0	COG0001@1|root,COG0001@2|Bacteria,2GKJV@201174|Actinobacteria,4EI3K@85012|Streptosporangiales	201174|Actinobacteria	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_959308_4	1380393.JHVP01000003_gene1268	4.123e-141	463.0	COG1073@1|root,COG2114@1|root,COG1073@2|Bacteria,COG2114@2|Bacteria,2IASU@201174|Actinobacteria	201174|Actinobacteria	IT	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
CMS3_k127_959308_16	287.DR97_5978	1.935e-34	142.0	COG3153@1|root,COG3153@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	ko:K03824	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_9
CMS3_k127_959308_14	1316936.K678_08364	1.249e-39	164.0	COG2114@1|root,COG2114@2|Bacteria,1N6I7@1224|Proteobacteria,2U3M0@28211|Alphaproteobacteria,2JZ9I@204441|Rhodospirillales	204441|Rhodospirillales	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
CMS3_k127_959308_18	1108045.GORHZ_008_00040	9.089e-11	74.0	COG2021@1|root,COG2197@1|root,COG2021@2|Bacteria,COG2197@2|Bacteria,2GN4Z@201174|Actinobacteria,4GGNX@85026|Gordoniaceae	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,GerE
CMS3_k127_959308_15	644966.Tmar_1595	1.097e-37	153.0	COG1622@1|root,COG1622@2|Bacteria,1TRC3@1239|Firmicutes,25348@186801|Clostridia	186801|Clostridia	C	Cytochrome C oxidase subunit II, periplasmic domain	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
CMS3_k127_959308_2	469383.Cwoe_1902	1.003e-169	555.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
CMS3_k127_959308_13	926569.ANT_05280	2.097e-42	165.0	COG1845@1|root,COG1845@2|Bacteria,2G74U@200795|Chloroflexi	200795|Chloroflexi	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
CMS3_k127_959308_21	1229780.BN381_840003	1.739e-08	64.0	COG3794@1|root,COG3794@2|Bacteria,2HC6V@201174|Actinobacteria	201174|Actinobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_959308_20	1347087.CBYO010000005_gene573	3.693e-09	64.0	COG2010@1|root,COG2010@2|Bacteria,1VEEP@1239|Firmicutes,4HP6N@91061|Bacilli	91061|Bacilli	C	COG2010 Cytochrome c, mono- and diheme variants	cccB	-	-	ko:K12263,ko:K13300	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
CMS3_k127_959308_9	1122918.KB907249_gene3893	8.439e-106	356.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,26WSQ@186822|Paenibacillaceae	91061|Bacilli	C	CoA-transferase family III	frc	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_968524_3	1122138.AQUZ01000078_gene6116	2.585e-36	142.0	COG3832@1|root,COG3832@2|Bacteria,2IFGN@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_968524_0	309801.trd_0354	1.605e-125	417.0	COG0621@1|root,COG0621@2|Bacteria,2G5QK@200795|Chloroflexi,27Y2T@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
CMS3_k127_968524_1	1382306.JNIM01000001_gene527	4.272e-50	186.0	COG1051@1|root,COG1051@2|Bacteria,2G6QH@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
CMS3_k127_968524_2	1146883.BLASA_2550	3.688e-47	188.0	COG2141@1|root,COG2141@2|Bacteria,2ICP1@201174|Actinobacteria,4EUVG@85013|Frankiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_971708_0	247633.GP2143_18001	0.0	1180.0	COG0439@1|root,COG1038@1|root,COG4799@1|root,COG0439@2|Bacteria,COG1038@2|Bacteria,COG4799@2|Bacteria,1MU4H@1224|Proteobacteria,1RQ9Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Biotin carboxylase	pyc	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
CMS3_k127_971708_2	479434.Sthe_2785	5.028e-52	200.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	2.8.1.7,4.4.1.16	ko:K03980,ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000,ko01011,ko02000	2.A.66.4	-	-	Peptidase_M28,SLH
CMS3_k127_971708_1	1121918.ARWE01000001_gene3150	2.325e-195	649.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,42P5Y@68525|delta/epsilon subdivisions,2WJEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
CMS3_k127_971708_3	1502851.FG93_00104	4.708e-29	123.0	COG3339@1|root,COG3339@2|Bacteria,1MZCY@1224|Proteobacteria,2UC5S@28211|Alphaproteobacteria,3K0TI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
CMS3_k127_980284_2	552811.Dehly_0985	2.408e-40	158.0	COG0745@1|root,COG0745@2|Bacteria,2GARH@200795|Chloroflexi,34D69@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Trans_reg_C
CMS3_k127_980284_3	290397.Adeh_3915	4.56e-34	145.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2YUI5@29|Myxococcales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
CMS3_k127_980284_1	1120949.KB903294_gene3893	1.885e-57	209.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4DEM5@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
CMS3_k127_980284_0	1382356.JQMP01000003_gene2108	6.715e-88	312.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,PTPS_related
CMS3_k127_980800_1	158500.BV97_01155	1.445e-158	509.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2K04I@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_980800_4	1209984.BN978_04465	0.0001344	46.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,232WV@1762|Mycobacteriaceae	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_980800_0	42256.RradSPS_0358	7.586e-205	668.0	COG2909@1|root,COG2909@2|Bacteria,2HENR@201174|Actinobacteria,4CPC9@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_22,GerE
CMS3_k127_980800_3	1273538.G159_04940	1.908e-13	75.0	2DNVA@1|root,32ZBE@2|Bacteria,1W480@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_980800_2	29540.C481_02342	9.423e-27	128.0	COG1033@1|root,arCOG02174@2157|Archaea,2XT5A@28890|Euryarchaeota,23SV0@183963|Halobacteria	183963|Halobacteria	L	exporters of the RND superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
CMS3_k127_994757_1	552811.Dehly_1471	4.223e-74	272.0	COG1198@1|root,COG1198@2|Bacteria,2G60J@200795|Chloroflexi,34D0F@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Helicase_C,ResIII
CMS3_k127_994757_2	639282.DEFDS_0250	2.315e-34	137.0	COG0335@1|root,COG0335@2|Bacteria,2GFPU@200930|Deferribacteres	200930|Deferribacteres	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
CMS3_k127_994757_0	997346.HMPREF9374_0878	1.135e-87	299.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,27BNR@186824|Thermoactinomycetaceae	91061|Bacilli	J	tRNA (Guanine-1)-methyltransferase	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
CMS3_k127_994757_3	706587.Desti_3592	1.582e-09	59.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,42PGH@68525|delta/epsilon subdivisions,2WPJ6@28221|Deltaproteobacteria,2MQG2@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	molybdenum cofactor	moaB	-	2.7.7.75	ko:K03638,ko:K03831	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
## 2726 queries scanned
## Total time (seconds): 194.60255408287048
## Rate: 14.01 q/s