## Sun Nov 10 08:49:52 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bins_4635/CMS3_bin.29.fa -m mmseqs --itype genome -o CMS3_bin.29 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/CMS3_bin.29 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
CMS3_k127_1009431_9	686340.Metal_2631	1.398e-25	106.0	COG3360@1|root,COG3360@2|Bacteria,1N6UT@1224|Proteobacteria,1SCF7@1236|Gammaproteobacteria,1XFQV@135618|Methylococcales	135618|Methylococcales	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
CMS3_k127_1009431_1	1499683.CCFF01000013_gene324	9.677e-200	631.0	COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,36EB6@31979|Clostridiaceae	186801|Clostridia	EJ	L-asparaginase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
CMS3_k127_1009431_0	1047013.AQSP01000142_gene185	7.889e-213	685.0	COG4447@1|root,COG4447@2|Bacteria,2NQ6W@2323|unclassified Bacteria	2|Bacteria	S	Por secretion system C-terminal sorting domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
CMS3_k127_1009431_3	1121949.AQXT01000002_gene2461	1.045e-57	215.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,43X6N@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	COG0846 NAD-dependent protein deacetylases, SIR2 family	MA20_30275	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
CMS3_k127_1009431_5	671143.DAMO_0253	1.61e-46	181.0	COG4552@1|root,COG4552@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_9,SCP2_2
CMS3_k127_1009431_7	234267.Acid_6639	9.234e-29	126.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_1009431_4	1193181.BN10_1720004	4.169e-51	191.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
CMS3_k127_1009431_8	1210908.HSB1_46030	2.276e-28	129.0	COG0677@1|root,arCOG00252@2157|Archaea,2XUJT@28890|Euryarchaeota,23SHZ@183963|Halobacteria	183963|Halobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS3_k127_1009431_6	665942.HMPREF1022_01299	4.19e-31	135.0	COG2230@1|root,COG2230@2|Bacteria,1NKE6@1224|Proteobacteria,432ND@68525|delta/epsilon subdivisions,2WXTJ@28221|Deltaproteobacteria,2M8K4@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
CMS3_k127_1009431_2	314230.DSM3645_10052	5.643e-145	478.0	COG0457@1|root,COG0457@2|Bacteria,2IXTF@203682|Planctomycetes	203682|Planctomycetes	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_1010540_0	886293.Sinac_6694	3.873e-70	270.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
CMS3_k127_1011502_4	530564.Psta_1321	1.12e-22	114.0	COG1277@1|root,COG1277@2|Bacteria,2IZFI@203682|Planctomycetes	203682|Planctomycetes	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1011502_1	530564.Psta_1320	9.548e-87	300.0	COG1131@1|root,COG1131@2|Bacteria,2IWSX@203682|Planctomycetes	203682|Planctomycetes	V	COG1131 ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_1011502_6	1297742.A176_06033	8.458e-08	66.0	2DW2Z@1|root,32V0P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1011502_0	756272.Plabr_0439	1.035e-117	389.0	COG0714@1|root,COG0714@2|Bacteria,2IXCY@203682|Planctomycetes	203682|Planctomycetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_1011502_5	756272.Plabr_0438	3.735e-10	64.0	COG1196@1|root,COG1196@2|Bacteria,2J1C6@203682|Planctomycetes	203682|Planctomycetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1011502_2	402777.KB235903_gene2620	7.879e-76	263.0	COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria,1H7AV@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
CMS3_k127_1011502_3	861299.J421_0277	5.788e-74	264.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	zraR	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_1012438_0	33876.JNXY01000009_gene9128	1.567e-07	63.0	COG1413@1|root,COG1413@2|Bacteria,2INKI@201174|Actinobacteria,4DHQ2@85008|Micromonosporales	201174|Actinobacteria	C	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS3_k127_1014894_1	530564.Psta_2436	4.268e-107	359.0	COG1530@1|root,COG1530@2|Bacteria,2IWSS@203682|Planctomycetes	203682|Planctomycetes	J	TIGRFAM ribonuclease, Rne Rng family	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
CMS3_k127_1014894_4	1385513.N780_02915	3.016e-15	79.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,4HIGK@91061|Bacilli,2YAMZ@289201|Pontibacillus	91061|Bacilli	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
CMS3_k127_1014894_3	1142394.PSMK_11760	1.143e-23	105.0	COG0211@1|root,COG0211@2|Bacteria,2J04T@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
CMS3_k127_1014894_0	330214.NIDE1100	3.628e-108	359.0	COG0536@1|root,COG0536@2|Bacteria,3J0E3@40117|Nitrospirae	40117|Nitrospirae	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
CMS3_k127_1014894_2	1489678.RDMS_03650	6.923e-96	326.0	COG2805@1|root,COG2805@2|Bacteria,1WI5S@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	NU	Tfp pilus assembly protein pilus retraction ATPase PilT	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS3_k127_101954_1	290397.Adeh_0078	4.354e-20	94.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	290397.Adeh_0078|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_101954_3	446470.Snas_0537	1.046e-18	102.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Kelch_1,Kelch_3,Kelch_6
CMS3_k127_101954_2	877455.Metbo_1958	3.762e-19	102.0	COG1520@1|root,COG3291@1|root,arCOG02487@1|root,arCOG02516@1|root,arCOG02555@1|root,arCOG09729@1|root,arCOG02487@2157|Archaea,arCOG02492@2157|Archaea,arCOG02508@2157|Archaea,arCOG02516@2157|Archaea,arCOG02555@2157|Archaea,arCOG09729@2157|Archaea	2157|Archaea	E	Polymorphic membrane protein, Chlamydia	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Big_5,CBM_6,CHB_HEX_C_1,NosD,PKD,PQQ_3,SBBP
CMS3_k127_101954_0	1453500.AT05_07360	6.97e-52	208.0	COG2931@1|root,COG2931@2|Bacteria,4NKF1@976|Bacteroidetes,1II60@117743|Flavobacteriia	976|Bacteroidetes	Q	A domain in the BMP inhibitor chordin and in microbial proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,SusE
CMS3_k127_101954_4	357808.RoseRS_2786	9.338e-16	85.0	COG1520@1|root,COG1520@2|Bacteria,2G9GE@200795|Chloroflexi,3774I@32061|Chloroflexia	32061|Chloroflexia	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1024095_0	1042377.AFPJ01000055_gene963	8.641e-76	268.0	28MA5@1|root,2ZANY@2|Bacteria,1RIQ2@1224|Proteobacteria,1S60Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1024095_1	1173027.Mic7113_2374	2.503e-25	115.0	COG2091@1|root,COG2091@2|Bacteria,1G5GA@1117|Cyanobacteria,1HAPE@1150|Oscillatoriales	1117|Cyanobacteria	H	Belongs to the P-Pant transferase superfamily	hetI	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
CMS3_k127_1028829_0	330214.NIDE1418	3.331e-34	151.0	COG1386@1|root,COG1386@2|Bacteria,3J15Z@40117|Nitrospirae	40117|Nitrospirae	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
CMS3_k127_1028829_1	349741.Amuc_1460	0.0007058	43.0	COG0484@1|root,COG0484@2|Bacteria,46TKC@74201|Verrucomicrobia,2ITUR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
CMS3_k127_1033795_1	1210884.HG799474_gene15161	4.203e-69	252.0	COG1686@1|root,COG1686@2|Bacteria,2IY9N@203682|Planctomycetes	203682|Planctomycetes	M	PFAM peptidase S11 D-alanyl-D-alanine carboxypeptidase	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Beta-lactamase2,PG_binding_1,Peptidase_S11
CMS3_k127_1033795_3	596152.DesU5LDRAFT_2631	3.993e-44	183.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
CMS3_k127_1033795_2	379066.GAU_1495	2.838e-63	231.0	COG0457@1|root,COG0457@2|Bacteria,1ZTCW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1033795_0	1121904.ARBP01000013_gene454	5.861e-111	390.0	COG3540@1|root,COG3540@2|Bacteria,4NDUS@976|Bacteroidetes,47NKM@768503|Cytophagia	976|Bacteroidetes	P	PhoD-like phosphatase	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD
CMS3_k127_1033795_5	1123242.JH636435_gene1455	4.575e-08	65.0	COG0265@1|root,COG0526@1|root,COG0265@2|Bacteria,COG0526@2|Bacteria,2J07Q@203682|Planctomycetes	203682|Planctomycetes	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_1033795_4	886293.Sinac_1102	3.289e-23	102.0	COG0526@1|root,COG0526@2|Bacteria,2J07Q@203682|Planctomycetes	203682|Planctomycetes	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_1034268_1	1121374.KB891576_gene331	3.014e-53	202.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1T4K6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	ppkA	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase,PEGA,Pkinase
CMS3_k127_1034268_0	1254432.SCE1572_50055	6.529e-75	264.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2Z2X4@29|Myxococcales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_1036413_0	395494.Galf_0012	6.538e-135	439.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2VHD1@28216|Betaproteobacteria,44V7Y@713636|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM alanine dehydrogenase PNT domain protein	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
CMS3_k127_1036413_1	1123508.JH636441_gene3312	1.051e-74	273.0	COG0521@1|root,COG0521@2|Bacteria,2IYUD@203682|Planctomycetes	203682|Planctomycetes	H	Molybdenum cofactor biosynthesis	-	-	2.7.7.75	ko:K03638,ko:K03831	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
CMS3_k127_1036413_2	349521.HCH_06953	1.197e-29	137.0	COG1506@1|root,COG1506@2|Bacteria,1P7CR@1224|Proteobacteria	1224|Proteobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1043137_0	497964.CfE428DRAFT_2531	2.548e-111	378.0	COG1216@1|root,COG4976@1|root,COG1216@2|Bacteria,COG4976@2|Bacteria,46W0C@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_1043137_1	530564.Psta_0406	3.315e-12	79.0	COG2304@1|root,COG2304@2|Bacteria,2IY1T@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA,VWA_3
CMS3_k127_1043137_2	593117.TGAM_1011	0.0005325	51.0	COG0533@1|root,arCOG01185@2157|Archaea,2XX5D@28890|Euryarchaeota,2436E@183968|Thermococci	183968|Thermococci	T	serine threonine protein kinase	-	GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	RIO1
CMS3_k127_1052776_0	1246474.ANBE01000028_gene1336	3.564e-81	283.0	COG2876@1|root,COG2876@2|Bacteria,2I3UA@201174|Actinobacteria,4EI1I@85012|Streptosporangiales	201174|Actinobacteria	E	NeuB family	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
CMS3_k127_1052776_4	1123242.JH636436_gene38	4.444e-15	87.0	2CNIE@1|root,32SH6@2|Bacteria,2J02V@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1052776_5	1210884.HG799464_gene10789	1.837e-10	65.0	2E7HG@1|root,331ZY@2|Bacteria,2J0MZ@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1052776_2	1123508.JH636447_gene7855	1.829e-36	153.0	COG0515@1|root,COG0515@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_1052776_1	215803.DB30_2018	4.747e-39	162.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YWMB@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_1052776_3	1123508.JH636449_gene7247	4.349e-29	128.0	COG0515@1|root,COG0515@2|Bacteria,2IYAA@203682|Planctomycetes	203682|Planctomycetes	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_1058012_0	344747.PM8797T_09164	2.052e-182	585.0	COG3119@1|root,COG3119@2|Bacteria,2IXHT@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS3_k127_1058012_1	1123508.JH636440_gene2102	5.455e-75	259.0	COG3000@1|root,COG3000@2|Bacteria,2J12U@203682|Planctomycetes	203682|Planctomycetes	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
CMS3_k127_1061150_4	1133849.O3I_002550	5.975e-06	57.0	COG2957@1|root,COG2957@2|Bacteria,2GM6J@201174|Actinobacteria,4FUFR@85025|Nocardiaceae	201174|Actinobacteria	E	Belongs to the agmatine deiminase family	aguA	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
CMS3_k127_1061150_3	1150600.ADIARSV_2993	2.391e-11	73.0	2CDBG@1|root,343FF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1061150_0	502025.Hoch_0991	2.167e-103	347.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,4313Z@68525|delta/epsilon subdivisions,2WX2K@28221|Deltaproteobacteria,2Z2QP@29|Myxococcales	28221|Deltaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
CMS3_k127_1061150_1	234267.Acid_1856	1.389e-13	84.0	COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y45M@57723|Acidobacteria	57723|Acidobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_2,SpoIIE
CMS3_k127_1061150_2	756067.MicvaDRAFT_1972	3.889e-13	83.0	COG0457@1|root,COG4122@1|root,COG4421@1|root,COG0457@2|Bacteria,COG4122@2|Bacteria,COG4421@2|Bacteria,1G29N@1117|Cyanobacteria,1H92V@1150|Oscillatoriales	1117|Cyanobacteria	G	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF563,Methyltransf_24,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_6,TPR_7,TPR_8
CMS3_k127_1066345_0	760154.Sulba_2264	7.008e-90	312.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2YMN1@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	Belongs to the DEAD box helicase family	deaD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
CMS3_k127_1066345_1	1304872.JAGC01000005_gene2045	1.596e-85	290.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2WING@28221|Deltaproteobacteria,2M8KT@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_3075	QueC
CMS3_k127_1066345_2	1297742.A176_04476	3.535e-06	60.0	COG4932@1|root,COG4932@2|Bacteria,1NXIX@1224|Proteobacteria,430KM@68525|delta/epsilon subdivisions,2WVSB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_1066345_3	1121434.AULY01000007_gene1357	0.0002708	49.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,42NBC@68525|delta/epsilon subdivisions,2WIMR@28221|Deltaproteobacteria,2M9HJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the arginase family	speB	-	3.5.3.1,3.5.3.11	ko:K01476,ko:K01480	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
CMS3_k127_1068502_4	1128421.JAGA01000001_gene2365	4.75e-74	270.0	COG1600@1|root,COG1600@2|Bacteria,2NNWV@2323|unclassified Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
CMS3_k127_1068502_0	1382304.JNIL01000001_gene130	8.55e-201	638.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4HBS1@91061|Bacilli,277VX@186823|Alicyclobacillaceae	91061|Bacilli	C	Aldehyde dehydrogenase family	rocA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
CMS3_k127_1068502_3	880072.Desac_0158	7.507e-81	277.0	COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,42P7H@68525|delta/epsilon subdivisions,2WKJA@28221|Deltaproteobacteria,2MQD3@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
CMS3_k127_1068502_6	411471.SUBVAR_04161	1.524e-31	131.0	COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,24DG3@186801|Clostridia,3WIVU@541000|Ruminococcaceae	186801|Clostridia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
CMS3_k127_1068502_2	1304880.JAGB01000002_gene1855	3.781e-88	303.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
CMS3_k127_1068502_1	1297742.A176_05284	5.261e-119	402.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2YUMA@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
CMS3_k127_1068502_7	1246626.BleG1_2015	1.533e-14	85.0	COG0723@1|root,COG0723@2|Bacteria,1TQUH@1239|Firmicutes,4HBX1@91061|Bacilli,1ZFNX@1386|Bacillus	91061|Bacilli	C	Menaquinol-cytochrome c reductase	qcrA	-	-	ko:K03886	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	CytB6-F_Fe-S,Rieske
CMS3_k127_1068502_5	330214.NIDE3889	2.045e-60	217.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,3J0Q6@40117|Nitrospirae	2|Bacteria	C	Cytochrome b/b6/petB	qcrC	-	-	ko:K00412,ko:K03888	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B,Cytochrome_CBB3
CMS3_k127_1074798_2	886293.Sinac_4403	5.843e-16	85.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	-	-	-	ko:K18844	-	-	-	-	ko00000,ko01504	-	-	-	APH
CMS3_k127_1074798_0	335543.Sfum_3550	7.564e-161	519.0	COG0438@1|root,COG0438@2|Bacteria,1NTNW@1224|Proteobacteria,42Z8E@68525|delta/epsilon subdivisions,2WTUS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1074798_1	489825.LYNGBM3L_21180	1.517e-64	234.0	COG0438@1|root,COG0438@2|Bacteria,1GCX5@1117|Cyanobacteria	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1078912_1	1297569.MESS2_1000038	8.154e-48	184.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,43PQD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Ubie_methyltran
CMS3_k127_1078912_2	497964.CfE428DRAFT_5249	2.817e-09	64.0	COG0457@1|root,COG0457@2|Bacteria	497964.CfE428DRAFT_5249|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1078912_0	1123248.KB893322_gene632	1.308e-104	352.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
CMS3_k127_1090104_0	56110.Oscil6304_0870	3.758e-21	103.0	COG2319@1|root,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1H7DY@1150|Oscillatoriales	1117|Cyanobacteria	A	Wd40 repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35,WD40
CMS3_k127_1118708_3	545276.KB898727_gene315	1.828e-06	51.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1WWBW@135613|Chromatiales	135613|Chromatiales	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS3_k127_1118708_2	1220534.B655_2035	1.096e-25	119.0	COG0500@1|root,arCOG01773@2157|Archaea,2Y131@28890|Euryarchaeota	28890|Euryarchaeota	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
CMS3_k127_1118708_0	391615.ABSJ01000039_gene1926	2.64e-136	440.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1J4YW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
CMS3_k127_1118708_1	1229780.BN381_130026	1.069e-57	211.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,3UWEV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iNJ661.Rv3436c	GATase_6,SIS
CMS3_k127_1122718_0	335543.Sfum_1982	6.175e-115	383.0	COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,42R9P@68525|delta/epsilon subdivisions,2WMSU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
CMS3_k127_1122718_1	502025.Hoch_5038	4.42e-111	370.0	COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,42Z17@68525|delta/epsilon subdivisions,2WURE@28221|Deltaproteobacteria,2YUPJ@29|Myxococcales	28221|Deltaproteobacteria	O	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,PD40,PDZ_2,Peptidase_M28
CMS3_k127_1122718_2	945713.IALB_1883	8.059e-13	70.0	COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,PD40,PDZ_2,Peptidase_M28
CMS3_k127_1131152_1	1121456.ATVA01000013_gene922	6.478e-117	400.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,2M8QA@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	elongation factor SelB, winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
CMS3_k127_1131152_4	744872.Spica_1391	2.981e-05	54.0	COG1579@1|root,COG1579@2|Bacteria,2J6JN@203691|Spirochaetes	203691|Spirochaetes	S	Zn-ribbon protein, possibly nucleic acid-binding	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
CMS3_k127_1131152_0	575540.Isop_3036	1.604e-175	568.0	COG0568@1|root,COG0568@2|Bacteria,2IXI3@203682|Planctomycetes	203682|Planctomycetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS3_k127_1131152_3	479432.Sros_2351	6.206e-29	130.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4EG9M@85012|Streptosporangiales	201174|Actinobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
CMS3_k127_1131152_2	1382356.JQMP01000003_gene2401	8.509e-58	209.0	COG0358@1|root,COG0358@2|Bacteria,2G65X@200795|Chloroflexi,27XKY@189775|Thermomicrobia	189775|Thermomicrobia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
CMS3_k127_1131289_1	435590.BVU_0381	9.904e-94	340.0	COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,2FMCJ@200643|Bacteroidia,4AKGS@815|Bacteroidaceae	976|Bacteroidetes	T	COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_1131289_2	398767.Glov_3074	9.582e-35	153.0	COG4191@1|root,COG4191@2|Bacteria,1QUMH@1224|Proteobacteria,42MM2@68525|delta/epsilon subdivisions,2X7N8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS3_k127_1131289_0	309801.trd_0755	2.94e-141	462.0	COG0112@1|root,COG0112@2|Bacteria,2G624@200795|Chloroflexi,27XXZ@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
CMS3_k127_1139817_1	388467.A19Y_0102	1.266e-06	60.0	COG2755@1|root,COG2755@2|Bacteria,1G3Y8@1117|Cyanobacteria,1H8QZ@1150|Oscillatoriales	1117|Cyanobacteria	E	SGNH hydrolase-like domain, acetyltransferase AlgX	-	-	-	-	-	-	-	-	-	-	-	-	ALGX
CMS3_k127_1139817_2	215803.DB30_5217	1.546e-06	59.0	COG1729@1|root,COG1729@2|Bacteria,1Q3F0@1224|Proteobacteria,42XMM@68525|delta/epsilon subdivisions,2WTBN@28221|Deltaproteobacteria,2YYTS@29|Myxococcales	28221|Deltaproteobacteria	S	B-box zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1139817_0	521674.Plim_3536	3.589e-116	387.0	COG3345@1|root,COG3345@2|Bacteria,2J1YM@203682|Planctomycetes	203682|Planctomycetes	G	Pfam:DUF303	-	-	-	-	-	-	-	-	-	-	-	-	SASA
CMS3_k127_1141048_1	204669.Acid345_2770	1.599e-38	149.0	COG3616@1|root,COG3616@2|Bacteria,3Y5RJ@57723|Acidobacteria,2JNYN@204432|Acidobacteriia	204432|Acidobacteriia	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
CMS3_k127_1141048_0	1121382.JQKG01000004_gene3986	4.444e-72	259.0	COG1858@1|root,COG1858@2|Bacteria,1WK3X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	COG1858 Cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
CMS3_k127_1141048_2	1415780.JPOG01000001_gene320	1.939e-07	64.0	COG3857@1|root,COG3857@2|Bacteria,1QUQD@1224|Proteobacteria,1T20Z@1236|Gammaproteobacteria,1X7NW@135614|Xanthomonadales	135614|Xanthomonadales	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
CMS3_k127_1145959_2	264730.PSPPH_1337	1.716e-13	77.0	COG0457@1|root,COG0457@2|Bacteria,1RBMC@1224|Proteobacteria,1S33Y@1236|Gammaproteobacteria,1Z9WW@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1145959_0	929703.KE386491_gene1413	1.454e-15	91.0	COG1361@1|root,COG3291@1|root,COG3292@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,COG3292@2|Bacteria,4PKMZ@976|Bacteroidetes,47XXW@768503|Cytophagia	976|Bacteroidetes	T	TIGRFAM Por secretion system C-terminal sorting domain	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C
CMS3_k127_1145959_1	72019.SARC_11747T0	2.357e-14	87.0	KOG1217@1|root,KOG1217@2759|Eukaryota,38BUP@33154|Opisthokonta	33154|Opisthokonta	T	calcium ion binding	-	-	-	ko:K02599	ko01522,ko04320,ko04330,ko04658,ko04919,ko05020,ko05165,ko05200,ko05206,ko05224,map01522,map04320,map04330,map04658,map04919,map05020,map05165,map05200,map05206,map05224	M00682	-	-	ko00000,ko00001,ko00002	-	-	-	EGF,SRCR,hEGF
CMS3_k127_1148243_1	1340493.JNIF01000003_gene2174	3.527e-32	136.0	COG1595@1|root,COG1595@2|Bacteria,3Y7Z3@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1148243_4	398527.Bphyt_6586	1.281e-08	66.0	COG1873@1|root,COG1873@2|Bacteria,1QTWZ@1224|Proteobacteria,2W1NC@28216|Betaproteobacteria,1K3PG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM PRC-barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PRC
CMS3_k127_1148243_5	1297863.APJF01000013_gene4122	2.107e-06	59.0	COG3861@1|root,COG3861@2|Bacteria,1MZM2@1224|Proteobacteria,2UBTQ@28211|Alphaproteobacteria,3JZPK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	PRC-barrel domain	MA20_07315	-	-	-	-	-	-	-	-	-	-	-	PRC
CMS3_k127_1148243_0	215803.DB30_3556	2.54e-52	199.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria,2YYWU@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_1148243_3	1047013.AQSP01000107_gene2083	4.444e-11	65.0	COG1373@1|root,COG1373@2|Bacteria,2NREE@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS3_k127_1148243_2	760192.Halhy_1750	2.194e-13	72.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_1150628_0	1121918.ARWE01000001_gene3079	4.073e-203	652.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42P5P@68525|delta/epsilon subdivisions,2WITN@28221|Deltaproteobacteria,43TQJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	HI0933-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_9,Pyr_redox_2
CMS3_k127_1150628_1	1121918.ARWE01000001_gene3080	1.645e-147	479.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,43TT3@69541|Desulfuromonadales	68525|delta/epsilon subdivisions	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
CMS3_k127_1150628_2	1121918.ARWE01000001_gene3081	6.337e-114	392.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria,43V7G@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1,1.2.7.7	ko:K00170,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
CMS3_k127_1150628_3	886293.Sinac_2761	8.267e-09	63.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IYTQ@203682|Planctomycetes	203682|Planctomycetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16
CMS3_k127_1152463_2	867900.Celly_0654	2.688e-10	71.0	2DUW9@1|root,33SPC@2|Bacteria,4P1AG@976|Bacteroidetes,1I792@117743|Flavobacteriia,1F9Z1@104264|Cellulophaga	976|Bacteroidetes	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_3
CMS3_k127_1152463_0	349161.Dred_2286	3.071e-18	95.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,262RV@186807|Peptococcaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1152463_4	857087.Metme_2888	0.0003547	53.0	COG3712@1|root,COG3712@2|Bacteria,1MZCK@1224|Proteobacteria,1S721@1236|Gammaproteobacteria	1236|Gammaproteobacteria	PT	FecR protein	-	-	-	ko:K07165	-	-	-	-	ko00000	-	-	-	DUF4880,DUF4974,FecR
CMS3_k127_1152463_1	6500.XP_005100813.1	1.234e-14	89.0	2BW0M@1|root,2QTDG@2759|Eukaryota,38G52@33154|Opisthokonta,3BGNE@33208|Metazoa,3CVZ1@33213|Bilateria	33208|Metazoa	S	Von Willebrand factor A	VWA3A	-	-	-	-	-	-	-	-	-	-	-	VWA_3
CMS3_k127_1152463_3	929703.KE386491_gene869	4.114e-08	58.0	COG0229@1|root,COG0229@2|Bacteria,4NQEY@976|Bacteroidetes,47PPC@768503|Cytophagia	976|Bacteroidetes	O	Conserved domain frequently associated with peptide methionine sulfoxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
CMS3_k127_1153162_1	1313172.YM304_05440	6.307e-52	186.0	COG0735@1|root,COG0735@2|Bacteria,2IFBR@201174|Actinobacteria,4CN4D@84992|Acidimicrobiia	84992|Acidimicrobiia	P	Ferric uptake regulator family	-	-	-	ko:K22297	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS3_k127_1153162_2	1068980.ARVW01000001_gene1364	1.532e-07	61.0	COG1595@1|root,COG1595@2|Bacteria,2GM8T@201174|Actinobacteria,4DY2F@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigD	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_1153162_0	886293.Sinac_6489	1.29e-63	250.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
CMS3_k127_1154615_0	1123242.JH636434_gene5531	9.767e-43	178.0	2EUN2@1|root,33N3X@2|Bacteria,2J1AF@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1161285_1	1304872.JAGC01000003_gene3276	9.794e-32	140.0	COG3291@1|root,COG3291@2|Bacteria,1PHGX@1224|Proteobacteria,437VV@68525|delta/epsilon subdivisions,2X1BB@28221|Deltaproteobacteria,2MEPR@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_5
CMS3_k127_1161285_0	344747.PM8797T_20638	2.866e-62	219.0	COG0415@1|root,COG0415@2|Bacteria,2IXWI@203682|Planctomycetes	203682|Planctomycetes	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase
CMS3_k127_1162374_1	1307759.JOMJ01000003_gene2352	7.291e-24	109.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2M9X5@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23
CMS3_k127_1162374_0	382464.ABSI01000011_gene2351	0.0	1629.0	COG0841@1|root,COG0841@2|Bacteria,46Z6Y@74201|Verrucomicrobia,2ITZB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS3_k127_11671_1	1449351.RISW2_02030	4.078e-18	98.0	COG3591@1|root,COG3591@2|Bacteria	2|Bacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
CMS3_k127_11671_0	1396418.BATQ01000117_gene4605	1.749e-86	317.0	COG2755@1|root,COG4409@1|root,COG2755@2|Bacteria,COG4409@2|Bacteria,46TCP@74201|Verrucomicrobia,2IWKC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EG	Carbohydrate esterase, sialic acid-specific acetylesterase	-	-	-	-	-	-	-	-	-	-	-	-	SASA
CMS3_k127_1167789_1	497964.CfE428DRAFT_6333	8.355e-29	119.0	COG2127@1|root,COG2127@2|Bacteria,46T8N@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
CMS3_k127_1167789_0	457570.Nther_1486	3.657e-208	661.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia	186801|Clostridia	I	PFAM Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
CMS3_k127_1167789_2	1123508.JH636452_gene7057	5.039e-19	95.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,2J2J0@203682|Planctomycetes	203682|Planctomycetes	S	Vault protein inter-alpha-trypsin domain	-	-	-	-	-	-	-	-	-	-	-	-	VIT,VWA_3
CMS3_k127_1170438_3	1122622.ATWJ01000008_gene2921	1.586e-20	106.0	arCOG06227@1|root,2ZCRG@2|Bacteria,2I96P@201174|Actinobacteria,4FE9G@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
CMS3_k127_1170438_2	309801.trd_A0753	2.583e-31	141.0	arCOG06227@1|root,2ZB70@2|Bacteria,2GAEH@200795|Chloroflexi,27Z5J@189775|Thermomicrobia	189775|Thermomicrobia	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
CMS3_k127_1170438_5	642492.Clole_1672	1.987e-05	55.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia	186801|Clostridia	O	PDZ DHR GLGF domain protein	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_1170438_1	292459.STH1622	1.707e-41	169.0	COG0457@1|root,COG3359@1|root,COG0457@2|Bacteria,COG3359@2|Bacteria,1TQQU@1239|Firmicutes	1239|Firmicutes	L	Exonuclease	yprB	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
CMS3_k127_1170438_0	717606.PaecuDRAFT_0767	3.514e-218	705.0	COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,1TSPA@1239|Firmicutes,4H9T2@91061|Bacilli,275MV@186822|Paenibacillaceae	91061|Bacilli	L	Domain of unknown function (DUF1998)	yprA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
CMS3_k127_1170438_4	314230.DSM3645_20287	1.089e-15	78.0	COG1073@1|root,COG1073@2|Bacteria,2IZ53@203682|Planctomycetes	203682|Planctomycetes	S	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2048,Peptidase_S9
CMS3_k127_1173434_1	483219.LILAB_28620	3.187e-08	66.0	COG1595@1|root,COG1595@2|Bacteria,1Q4ZI@1224|Proteobacteria,42TYH@68525|delta/epsilon subdivisions,2WQNG@28221|Deltaproteobacteria,2YYP8@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	carQ	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_1173434_0	313606.M23134_06792	3.688e-23	107.0	28ZCA@1|root,2ZM41@2|Bacteria,4NMWJ@976|Bacteroidetes,47PNS@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1174856_0	331869.BAL199_05914	4.958e-145	472.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS2I@28211|Alphaproteobacteria,4BPSX@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
CMS3_k127_1174856_7	649743.HMPREF0972_01717	0.0002788	53.0	COG1216@1|root,COG1216@2|Bacteria,2I0PW@201174|Actinobacteria,4D51P@85005|Actinomycetales	201174|Actinobacteria	S	Glycosyl transferase family 2	-	-	-	ko:K12990	ko02024,ko02025,map02024,map02025	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01005	-	GT2	-	Glycos_transf_2
CMS3_k127_1174856_5	426114.THI_0362	2.854e-24	117.0	COG1216@1|root,COG1216@2|Bacteria,1R6SJ@1224|Proteobacteria,2VPPE@28216|Betaproteobacteria,1KP57@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
CMS3_k127_1174856_4	1380408.AVGH01000033_gene481	3.719e-26	122.0	COG1216@1|root,COG1216@2|Bacteria,1UYRR@1239|Firmicutes,4HEJ1@91061|Bacilli	91061|Bacilli	S	glycosyl transferase family 2	galnac-T15	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glyco_transf_7C,Glycos_transf_2
CMS3_k127_1174856_6	768671.ThimaDRAFT_1532	1.007e-19	98.0	COG0463@1|root,COG2120@1|root,COG0463@2|Bacteria,COG2120@2|Bacteria,1R4JR@1224|Proteobacteria,1RZTQ@1236|Gammaproteobacteria,1X2DW@135613|Chromatiales	135613|Chromatiales	M	PFAM N-acetylglucosaminyl phosphatidylinositol deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS3_k127_1174856_1	671143.DAMO_0255	2.484e-58	220.0	COG0438@1|root,COG3754@1|root,COG4372@1|root,COG5610@1|root,COG0438@2|Bacteria,COG3754@2|Bacteria,COG4372@2|Bacteria,COG5610@2|Bacteria,2NR6D@2323|unclassified Bacteria	2|Bacteria	M	Evidence 5 No homology to any previously reported sequences	sll1424	-	2.1.1.80,3.1.1.61	ko:K01991,ko:K02557,ko:K07161,ko:K07484,ko:K13924,ko:K20444,ko:K21471	ko02020,ko02026,ko02030,ko02040,map02020,map02026,map02030,map02040	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01005,ko01011,ko02000,ko02022,ko02035	1.A.30.1,1.B.18,4.D.1.3	GT2,GT4	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,DUF3084,LZ_Tnp_IS66,zf-IS66
CMS3_k127_1174856_2	671143.DAMO_0254	8.79e-36	146.0	COG2120@1|root,COG2120@2|Bacteria,2NQ6H@2323|unclassified Bacteria	2|Bacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463,ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2,PIG-L
CMS3_k127_1174856_3	1265502.KB905942_gene2833	5.555e-31	129.0	COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,2VV87@28216|Betaproteobacteria,4AFMD@80864|Comamonadaceae	28216|Betaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_trans_1_4,Glycos_transf_2
CMS3_k127_1177669_0	756272.Plabr_1378	1.032e-103	347.0	COG0482@1|root,COG0482@2|Bacteria,2IXFF@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
CMS3_k127_1177669_1	1123070.KB899254_gene1170	4.975e-23	105.0	COG0776@1|root,COG0776@2|Bacteria,46T4R@74201|Verrucomicrobia,2IUNA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS3_k127_1177669_2	179408.Osc7112_4859	1.906e-06	59.0	COG1413@1|root,COG1413@2|Bacteria,1G233@1117|Cyanobacteria,1H7RE@1150|Oscillatoriales	1117|Cyanobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS3_k127_1188826_2	1288826.MSNKSG1_14572	2.873e-10	68.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,466HH@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
CMS3_k127_1188826_0	880073.Calab_1195	5.014e-248	808.0	COG0841@1|root,COG0841@2|Bacteria,2NQI6@2323|unclassified Bacteria	2|Bacteria	V	AcrB/AcrD/AcrF family	mdtB	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS3_k127_1188826_1	293826.Amet_0188	4.646e-35	147.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,36F39@31979|Clostridiaceae	186801|Clostridia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS3_k127_1193902_0	105559.Nwat_0647	3.347e-170	544.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1WWTN@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,SufE
CMS3_k127_1193902_1	713587.THITH_12765	3.094e-46	184.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
CMS3_k127_1193902_3	1385517.N800_04020	4.458e-09	62.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,1S36X@1236|Gammaproteobacteria,1X3XG@135614|Xanthomonadales	135614|Xanthomonadales	S	FeS assembly SUF system protein SufT	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
CMS3_k127_1193902_2	1304275.C41B8_11895	3.487e-37	142.0	COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1SAAA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Rieske 2Fe-2S	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
CMS3_k127_119735_6	1121346.KB899836_gene1305	2.557e-06	51.0	COG0712@1|root,COG0712@2|Bacteria,1VAG3@1239|Firmicutes,4HKFW@91061|Bacilli,26UM4@186822|Paenibacillaceae	91061|Bacilli	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
CMS3_k127_119735_1	1191523.MROS_0272	1.098e-193	617.0	COG0056@1|root,COG0056@2|Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016469,GO:0030312,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	iSB619.SA_RS10975	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
CMS3_k127_119735_3	237368.SCABRO_01310	1.141e-58	218.0	COG0224@1|root,COG0224@2|Bacteria,2IXDI@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
CMS3_k127_119735_0	661478.OP10G_4764	5.883e-196	627.0	COG0055@1|root,COG0055@2|Bacteria	2|Bacteria	C	proton-transporting ATP synthase activity, rotational mechanism	atpD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
CMS3_k127_119735_5	867903.ThesuDRAFT_02399	1.011e-19	94.0	COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia,3WCNT@538999|Clostridiales incertae sedis	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01195	ATP-synt_DE,ATP-synt_DE_N
CMS3_k127_119735_4	246197.MXAN_2662	2.597e-34	140.0	COG0494@1|root,COG0494@2|Bacteria,1Q2GD@1224|Proteobacteria,433T7@68525|delta/epsilon subdivisions,2X3CU@28221|Deltaproteobacteria,2YVG9@29|Myxococcales	28221|Deltaproteobacteria	L	nUDIX hydrolase	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
CMS3_k127_119735_2	247634.GPB2148_756	7.402e-111	370.0	COG0535@1|root,COG0535@2|Bacteria,1NEM7@1224|Proteobacteria	1224|Proteobacteria	M	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS3_k127_120685_9	247490.KSU1_C1209	2.28e-46	180.0	COG0088@1|root,COG0088@2|Bacteria,2IYU2@203682|Planctomycetes	203682|Planctomycetes	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
CMS3_k127_120685_15	671143.DAMO_0541	5.112e-25	106.0	COG0089@1|root,COG0089@2|Bacteria,2NPWC@2323|unclassified Bacteria	2|Bacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
CMS3_k127_120685_1	344747.PM8797T_12213	1.279e-113	373.0	COG0090@1|root,COG0090@2|Bacteria,2IXD9@203682|Planctomycetes	203682|Planctomycetes	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
CMS3_k127_120685_12	518766.Rmar_0846	2.356e-32	127.0	COG0185@1|root,COG0185@2|Bacteria,4NQ8T@976|Bacteroidetes,1FJGN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
CMS3_k127_120685_19	648996.Theam_0262	2.069e-20	100.0	COG0091@1|root,COG0091@2|Bacteria,2G4B2@200783|Aquificae	200783|Aquificae	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
CMS3_k127_120685_2	886293.Sinac_0479	4.325e-70	250.0	COG0092@1|root,COG0092@2|Bacteria,2IWWU@203682|Planctomycetes	203682|Planctomycetes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
CMS3_k127_120685_7	237368.SCABRO_03498	9.433e-52	186.0	COG0197@1|root,COG0197@2|Bacteria,2IZPH@203682|Planctomycetes	203682|Planctomycetes	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
CMS3_k127_120685_18	760192.Halhy_4751	1.536e-21	96.0	COG0186@1|root,COG0186@2|Bacteria,4NSB2@976|Bacteroidetes,1IT9T@117747|Sphingobacteriia	976|Bacteroidetes	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
CMS3_k127_120685_8	247490.KSU1_C1218	3.401e-50	180.0	COG0093@1|root,COG0093@2|Bacteria,2IZMA@203682|Planctomycetes	203682|Planctomycetes	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
CMS3_k127_120685_16	1301100.HG529435_gene6480	7.188e-22	99.0	COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,24MY0@186801|Clostridia,36JMF@31979|Clostridiaceae	186801|Clostridia	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
CMS3_k127_120685_3	1046714.AMRX01000007_gene2310	1.052e-65	228.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,464A7@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
CMS3_k127_120685_17	247490.KSU1_C1221	1.064e-21	96.0	COG0199@1|root,COG0199@2|Bacteria,2J0QE@203682|Planctomycetes	203682|Planctomycetes	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
CMS3_k127_120685_10	266117.Rxyl_2141	9.014e-43	163.0	COG0096@1|root,COG0096@2|Bacteria,2IHQZ@201174|Actinobacteria,4CQGZ@84995|Rubrobacteria	84995|Rubrobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
CMS3_k127_120685_5	1122238.AULR01000018_gene169	1.046e-57	209.0	COG0097@1|root,COG0097@2|Bacteria,2GK35@201174|Actinobacteria,4FKG8@85023|Microbacteriaceae	201174|Actinobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
CMS3_k127_120685_14	460265.Mnod_1924	7.003e-29	128.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2U9A6@28211|Alphaproteobacteria,1JUZF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
CMS3_k127_120685_6	649747.HMPREF0083_05141	8.949e-53	193.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,4HFN4@91061|Bacilli,26U4W@186822|Paenibacillaceae	91061|Bacilli	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
CMS3_k127_120685_11	1121936.AUHI01000018_gene688	2.246e-34	145.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,4HFPW@91061|Bacilli	91061|Bacilli	J	binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
CMS3_k127_120685_0	237368.SCABRO_03487	2.081e-115	387.0	COG0201@1|root,COG0201@2|Bacteria,2IXN6@203682|Planctomycetes	203682|Planctomycetes	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
CMS3_k127_120685_4	1125863.JAFN01000001_gene3315	1.835e-63	224.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
CMS3_k127_120685_13	237368.SCABRO_03484	5.789e-32	127.0	COG0361@1|root,COG0361@2|Bacteria,2J0T1@203682|Planctomycetes	203682|Planctomycetes	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
CMS3_k127_1208902_3	1123060.JONP01000059_gene2477	6.592e-34	132.0	COG3039@1|root,COG3039@2|Bacteria,1RAFC@1224|Proteobacteria,2VGSG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	IS5 family transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_5
CMS3_k127_1208902_2	1125863.JAFN01000001_gene1239	1.338e-143	497.0	COG0493@1|root,COG4231@1|root,COG0493@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WKYE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-2	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
CMS3_k127_1208902_4	1265505.ATUG01000002_gene2078	1.522e-32	145.0	COG1014@1|root,COG1014@2|Bacteria,1RBZA@1224|Proteobacteria,42QT3@68525|delta/epsilon subdivisions,2X6H9@28221|Deltaproteobacteria,2MJ4W@213118|Desulfobacterales	28221|Deltaproteobacteria	C	indolepyruvate ferredoxin oxidoreductase, beta subunit	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
CMS3_k127_1208902_0	1125863.JAFN01000001_gene1223	1.74e-249	796.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42NFP@68525|delta/epsilon subdivisions,2WK64@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EQ	PFAM Hydantoinase oxoprolinase	hyuA	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
CMS3_k127_1208902_1	76114.ebA2053	3.357e-241	779.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VITF@28216|Betaproteobacteria,2KXQJ@206389|Rhodocyclales	206389|Rhodocyclales	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
CMS3_k127_1214362_1	760192.Halhy_0663	8.259e-92	308.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
CMS3_k127_1214362_2	1142394.PSMK_14770	8.713e-40	161.0	COG1560@1|root,COG1560@2|Bacteria,2IY7N@203682|Planctomycetes	203682|Planctomycetes	M	Lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
CMS3_k127_1214362_4	1396418.BATQ01000132_gene3987	1.933e-37	147.0	COG2259@1|root,COG2259@2|Bacteria,46T2M@74201|Verrucomicrobia,2IUPP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
CMS3_k127_1214362_3	1340493.JNIF01000003_gene4229	1.27e-38	150.0	COG1846@1|root,COG1846@2|Bacteria,3Y5EQ@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27
CMS3_k127_1214362_0	1123242.JH636435_gene2121	2.3e-110	368.0	28KJF@1|root,2Z84W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1215466_1	247490.KSU1_D0931	7.249e-52	201.0	COG2433@1|root,COG2433@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K12065	-	-	-	-	ko00000,ko02044	3.A.7.11.1	-	-	Porin_O_P
CMS3_k127_1215466_2	237368.SCABRO_04038	2.034e-21	108.0	COG1477@1|root,COG3901@1|root,COG1477@2|Bacteria,COG3901@2|Bacteria,2IYYX@203682|Planctomycetes	203682|Planctomycetes	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE,FMN_bind
CMS3_k127_1215466_0	945713.IALB_1632	3.328e-95	327.0	COG1007@1|root,COG1007@2|Bacteria	2|Bacteria	C	ATP synthesis coupled electron transport	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
CMS3_k127_1217806_1	111780.Sta7437_4145	3.284e-21	100.0	COG1359@1|root,COG1359@2|Bacteria,1GB91@1117|Cyanobacteria,3VKT8@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
CMS3_k127_1217806_0	595460.RRSWK_05929	2.351e-30	134.0	COG3527@1|root,COG3527@2|Bacteria,2J4RG@203682|Planctomycetes	203682|Planctomycetes	Q	Alpha-acetolactate decarboxylase	-	-	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660	-	R02948	RC00812	ko00000,ko00001,ko01000	-	-	-	-
CMS3_k127_1243412_0	1499967.BAYZ01000074_gene2084	1.654e-46	176.0	COG0561@1|root,COG0561@2|Bacteria,2NQZK@2323|unclassified Bacteria	2|Bacteria	S	Sucrose-6F-phosphate phosphohydrolase	ybhA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033883,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050308	-	-	-	-	-	-	-	-	-	iECSP_1301.ECSP_0819,iECs_1301.ECs0794,iG2583_1286.G2583_0932,iZ_1308.Z0936	Hydrolase_3
CMS3_k127_1243412_1	1210884.HG799474_gene15134	6.105e-31	132.0	COG1506@1|root,COG1506@2|Bacteria,2J2ME@203682|Planctomycetes	203682|Planctomycetes	E	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
CMS3_k127_1250071_5	886293.Sinac_7408	4.904e-22	108.0	COG1191@1|root,COG1191@2|Bacteria,2IX9S@203682|Planctomycetes	203682|Planctomycetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS3_k127_1250071_6	765952.PUV_10420	3.168e-14	85.0	COG0319@1|root,COG0319@2|Bacteria,2JG8S@204428|Chlamydiae	204428|Chlamydiae	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
CMS3_k127_1250071_1	595460.RRSWK_03690	4.07e-87	302.0	COG1702@1|root,COG1702@2|Bacteria,2IXBB@203682|Planctomycetes	203682|Planctomycetes	T	Phosphate starvation-inducible protein PhoH	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
CMS3_k127_1250071_3	1449337.JQLL01000001_gene466	4.065e-26	120.0	COG4589@1|root,COG4589@2|Bacteria,1TT0Q@1239|Firmicutes,4HAMN@91061|Bacilli,27GD4@186828|Carnobacteriaceae	91061|Bacilli	S	Cytidylyltransferase family	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS06255	CTP_transf_1
CMS3_k127_1250071_2	589865.DaAHT2_0971	3.89e-75	260.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,42PTV@68525|delta/epsilon subdivisions,2WMWK@28221|Deltaproteobacteria,2MIZD@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
CMS3_k127_1250071_0	1304874.JAFY01000007_gene1724	1.886e-129	427.0	COG0104@1|root,COG0104@2|Bacteria,3TA4C@508458|Synergistetes	508458|Synergistetes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
CMS3_k127_1250071_4	469383.Cwoe_1856	3.263e-24	104.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4CRNM@84995|Rubrobacteria	84995|Rubrobacteria	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
CMS3_k127_1256879_1	240292.Ava_0582	6.789e-12	70.0	COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,1G0EB@1117|Cyanobacteria	1117|Cyanobacteria	DZ	PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,DUF4347,He_PIG,HemolysinCabind,PPC,TIG,VCBS
CMS3_k127_1256879_0	388467.A19Y_3447	3.48e-24	119.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1H8D7@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
CMS3_k127_1260223_3	1347393.HG726020_gene845	5.807e-16	81.0	COG0636@1|root,COG0636@2|Bacteria,4NURW@976|Bacteroidetes,2FTSZ@200643|Bacteroidia,4ARQC@815|Bacteroidaceae	976|Bacteroidetes	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
CMS3_k127_1260223_1	1191523.MROS_0276	4.969e-48	190.0	COG0356@1|root,COG0356@2|Bacteria	2|Bacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
CMS3_k127_1260223_4	1121396.KB893123_gene1070	0.0001105	50.0	COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,42VWC@68525|delta/epsilon subdivisions,2WS5S@28221|Deltaproteobacteria,2MKV4@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
CMS3_k127_1260223_0	671143.DAMO_0072	2.063e-142	473.0	COG1220@1|root,COG1220@2|Bacteria,2NP00@2323|unclassified Bacteria	2|Bacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
CMS3_k127_1260223_2	1286093.C266_07397	9.145e-20	96.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,1K1T9@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1260635_2	497964.CfE428DRAFT_5319	5.586e-39	154.0	2BYG0@1|root,32TGP@2|Bacteria,46VS0@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1260635_0	700598.Niako_5898	8.35e-129	431.0	COG0714@1|root,COG0714@2|Bacteria,4NIHC@976|Bacteroidetes,1IQRD@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM ATPase associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_5
CMS3_k127_1260635_3	497964.CfE428DRAFT_5317	1.233e-36	158.0	2AE26@1|root,313V0@2|Bacteria,46W80@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1260635_1	497964.CfE428DRAFT_5316	1.411e-51	198.0	COG2425@1|root,COG2425@2|Bacteria,46VBK@74201|Verrucomicrobia	74201|Verrucomicrobia	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1271417_0	449447.MAE_61060	1.582e-74	263.0	COG2931@1|root,COG2931@2|Bacteria,1GQCK@1117|Cyanobacteria	1117|Cyanobacteria	Q	PFAM Hemolysin-type calcium-binding	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Calx-beta,DUF4347,HemolysinCabind,VCBS
CMS3_k127_1271417_1	56110.Oscil6304_1013	4.621e-28	120.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
CMS3_k127_1277432_16	289377.HL41_06260	6.326e-11	69.0	COG0859@1|root,COG0859@2|Bacteria,2GGZ0@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS3_k127_1277432_11	634497.HAH_1364	2.833e-35	146.0	COG0589@1|root,arCOG00449@2157|Archaea,2XU1E@28890|Euryarchaeota,23TYX@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_1277432_7	290397.Adeh_4094	3.57e-47	184.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,42TKK@68525|delta/epsilon subdivisions,2X5NX@28221|Deltaproteobacteria,2Z0PZ@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
CMS3_k127_1277432_9	290397.Adeh_3956	1.07e-41	163.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1277432_1	502025.Hoch_5743	4.484e-285	907.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,42NJZ@68525|delta/epsilon subdivisions,2WK1Q@28221|Deltaproteobacteria,2YZK2@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
CMS3_k127_1277432_12	502025.Hoch_5742	2.451e-27	115.0	COG4327@1|root,COG4327@2|Bacteria,1N0TK@1224|Proteobacteria,42VFF@68525|delta/epsilon subdivisions,2WR8E@28221|Deltaproteobacteria,2Z2T8@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4212)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
CMS3_k127_1277432_8	215803.DB30_5213	9.08e-42	177.0	COG1409@1|root,COG3291@1|root,COG1409@2|Bacteria,COG3291@2|Bacteria,1N85S@1224|Proteobacteria,42WZ6@68525|delta/epsilon subdivisions,2XA07@28221|Deltaproteobacteria,2YZHM@29|Myxococcales	28221|Deltaproteobacteria	S	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,PKD
CMS3_k127_1277432_13	1144275.COCOR_05693	5.559e-27	117.0	COG2363@1|root,COG2363@2|Bacteria,1MZX3@1224|Proteobacteria,42UHB@68525|delta/epsilon subdivisions,2WQHM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF423)	-	-	-	-	-	-	-	-	-	-	-	-	DUF423
CMS3_k127_1277432_3	395961.Cyan7425_3934	3.549e-197	633.0	COG1166@1|root,COG1166@2|Bacteria,1G1C4@1117|Cyanobacteria,3KGEW@43988|Cyanothece	1117|Cyanobacteria	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
CMS3_k127_1277432_14	986075.CathTA2_1857	5.058e-23	102.0	COG1225@1|root,COG1225@2|Bacteria,1V6MU@1239|Firmicutes,4HK8J@91061|Bacilli	91061|Bacilli	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_1277432_17	411471.SUBVAR_04865	2.885e-08	56.0	COG1225@1|root,COG1225@2|Bacteria,1V3N5@1239|Firmicutes,24HP8@186801|Clostridia,3WIK4@541000|Ruminococcaceae	186801|Clostridia	O	Redoxin	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
CMS3_k127_1277432_0	240292.Ava_2762	0.0	1191.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1G1HW@1117|Cyanobacteria,1HJRQ@1161|Nostocales	1117|Cyanobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
CMS3_k127_1277432_2	1380394.JADL01000024_gene101	6.182e-267	842.0	COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,2JRCI@204441|Rhodospirillales	204441|Rhodospirillales	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	1.14.13.40	ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Oxidored_FMN
CMS3_k127_1277432_6	570952.ATVH01000017_gene1626	1.315e-49	200.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,2JQMA@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,SSF
CMS3_k127_1277432_10	1089551.KE386572_gene2982	2.857e-40	170.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,4BR5K@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_7,Response_reg,SSF
CMS3_k127_1277432_4	1192034.CAP_3718	2.564e-83	284.0	COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,42KZ6@68525|delta/epsilon subdivisions,2WVSN@28221|Deltaproteobacteria,2Z1YP@29|Myxococcales	28221|Deltaproteobacteria	F	Protein of unknown function (DUF455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF455
CMS3_k127_1277432_5	448385.sce0971	5.575e-63	227.0	29XG3@1|root,30J6J@2|Bacteria,1QSSU@1224|Proteobacteria,4355H@68525|delta/epsilon subdivisions,2X95V@28221|Deltaproteobacteria,2Z23G@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1277432_15	527002.yaldo0001_1760	1.025e-12	70.0	COG3155@1|root,COG3155@2|Bacteria,1MW2K@1224|Proteobacteria,1RMDJ@1236|Gammaproteobacteria,41DQR@629|Yersinia	1236|Gammaproteobacteria	Q	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate	elbB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009893,GO:0009987,GO:0019216,GO:0019222,GO:0019747,GO:0031323,GO:0031325,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045828,GO:0045834,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:0071704,GO:0080090,GO:1901576	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
CMS3_k127_1281193_1	987059.RBXJA2T_12607	1.236e-47	172.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2VQ2I@28216|Betaproteobacteria,1KKKM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
CMS3_k127_1281193_2	945713.IALB_1636	1.731e-29	122.0	COG0316@1|root,COG0316@2|Bacteria	2|Bacteria	S	protein maturation	sufA	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
CMS3_k127_1281193_3	1177928.TH2_11694	2.45e-11	72.0	COG1076@1|root,COG1076@2|Bacteria,1RHZX@1224|Proteobacteria,2U78T@28211|Alphaproteobacteria,2JSDD@204441|Rhodospirillales	204441|Rhodospirillales	O	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA	hscB	-	-	ko:K04082	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,HSCB_C
CMS3_k127_1281193_0	204669.Acid345_0480	2.938e-143	474.0	COG0443@1|root,COG0443@2|Bacteria,3Y2F8@57723|Acidobacteria,2JIVF@204432|Acidobacteriia	204432|Acidobacteriia	O	heat shock protein 70	-	-	-	ko:K04043,ko:K04044	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33,1.A.33.1	-	-	HSP70
CMS3_k127_1281922_0	1313172.YM304_35170	5.093e-100	332.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
CMS3_k127_1285674_2	316067.Geob_2222	5.082e-18	94.0	2C6TB@1|root,32RHR@2|Bacteria,1RKX5@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1285674_4	1395513.P343_12870	3.376e-05	53.0	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,4HRBT@91061|Bacilli	91061|Bacilli	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
CMS3_k127_1285674_1	285514.JNWO01000013_gene6005	1.769e-27	118.0	COG3770@1|root,COG3770@2|Bacteria,2IQ1A@201174|Actinobacteria	201174|Actinobacteria	M	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M74
CMS3_k127_1285674_0	1296416.JACB01000015_gene4722	1.318e-79	293.0	COG1572@1|root,COG2356@1|root,COG3227@1|root,COG1572@2|Bacteria,COG2356@2|Bacteria,COG3227@2|Bacteria,4NHWZ@976|Bacteroidetes,1HZTV@117743|Flavobacteriia,2YGVV@290174|Aquimarina	976|Bacteroidetes	L	MAM domain, meprin/A5/mu	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,MAM,fn3
CMS3_k127_1285674_3	448385.sce6218	5.17e-15	89.0	COG1595@1|root,COG1595@2|Bacteria,1Q3FA@1224|Proteobacteria,4397F@68525|delta/epsilon subdivisions,2X4EA@28221|Deltaproteobacteria,2YYUV@29|Myxococcales	28221|Deltaproteobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1288498_1	344747.PM8797T_24886	1.832e-15	80.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	1.11.1.7	ko:K19511	-	-	-	-	ko00000,ko01000	-	-	-	CAP,HemolysinCabind,Peptidase_M10_C,VCBS
CMS3_k127_1288498_0	344747.PM8797T_24886	2.418e-62	226.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	1.11.1.7	ko:K19511	-	-	-	-	ko00000,ko01000	-	-	-	CAP,HemolysinCabind,Peptidase_M10_C,VCBS
CMS3_k127_1293326_0	448385.sce4866	8.758e-56	219.0	COG1215@1|root,COG1215@2|Bacteria,1R6Z6@1224|Proteobacteria,43ARY@68525|delta/epsilon subdivisions,2X661@28221|Deltaproteobacteria,2Z15Y@29|Myxococcales	28221|Deltaproteobacteria	M	Cellulose synthase	-	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Glyco_transf_21
CMS3_k127_1297945_0	187272.Mlg_1087	2.966e-90	311.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1WX6R@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_1297945_2	391625.PPSIR1_11943	7.411e-65	247.0	COG3298@1|root,COG3298@2|Bacteria	2|Bacteria	L	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB	wlaX	-	-	ko:K07501	-	-	-	-	ko00000	-	-	-	DNA_pol_B_exo2
CMS3_k127_1297945_1	292459.STH1116	9.802e-77	274.0	COG1078@1|root,COG1078@2|Bacteria,1TPVB@1239|Firmicutes,24DGJ@186801|Clostridia	186801|Clostridia	S	SMART metal-dependent phosphohydrolase, HD	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
CMS3_k127_1305220_1	886293.Sinac_7484	4.484e-48	184.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1305220_0	502025.Hoch_1711	4.884e-68	246.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria	1224|Proteobacteria	M	PFAM Formylglycine-generating sulfatase enzyme	-	-	2.7.11.1	ko:K11912,ko:K20333	ko02024,ko02025,ko03070,map02024,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase,PEGA,Pkinase,TIR_2
CMS3_k127_1309995_3	525904.Tter_1099	6.054e-07	62.0	COG2856@1|root,COG2856@2|Bacteria,2NQY0@2323|unclassified Bacteria	2|Bacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1309995_0	1201290.M902_0763	5.976e-133	451.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2WWD4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	oligopeptide transporter, OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
CMS3_k127_1309995_1	1267534.KB906760_gene1406	8.143e-92	321.0	COG0591@1|root,COG0591@2|Bacteria,3Y34J@57723|Acidobacteria,2JIBW@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307,ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21,2.A.21.2	-	-	SSF
CMS3_k127_1309995_2	579137.Metvu_0869	1.971e-21	97.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,23Q49@183939|Methanococci	183939|Methanococci	J	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
CMS3_k127_1316967_1	378806.STAUR_4113	0.0003154	51.0	COG0793@1|root,COG4932@1|root,COG0793@2|Bacteria,COG4932@2|Bacteria,1Q335@1224|Proteobacteria,438TX@68525|delta/epsilon subdivisions,2X402@28221|Deltaproteobacteria,2YXS3@29|Myxococcales	28221|Deltaproteobacteria	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_1316967_0	1142394.PSMK_26780	4.071e-62	237.0	COG0589@1|root,COG1808@1|root,COG0589@2|Bacteria,COG1808@2|Bacteria,2J3I1@203682|Planctomycetes	203682|Planctomycetes	T	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
CMS3_k127_1318119_0	1237149.C900_00402	1.94e-58	211.0	COG0596@1|root,COG0596@2|Bacteria,4PNPN@976|Bacteroidetes,47XAU@768503|Cytophagia	976|Bacteroidetes	S	Ndr family	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
CMS3_k127_1318738_2	1192034.CAP_3819	9.099e-26	112.0	COG2271@1|root,COG2271@2|Bacteria,1MX4V@1224|Proteobacteria,42QEQ@68525|delta/epsilon subdivisions,2WQEB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K02445,ko:K07783	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.1.4.3,2.A.1.4.4,2.A.1.4.6	-	-	MFS_1
CMS3_k127_1318738_1	439235.Dalk_4167	2.878e-67	244.0	29M87@1|root,3085U@2|Bacteria,1RFIW@1224|Proteobacteria,42ZD2@68525|delta/epsilon subdivisions,2WTTF@28221|Deltaproteobacteria,2MMZC@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1318738_0	1265503.KB905161_gene3155	7.482e-68	240.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
CMS3_k127_132210_2	379066.GAU_1210	6.109e-33	133.0	COG4409@1|root,COG4409@2|Bacteria,1ZUBR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_132210_1	1183438.GKIL_3942	4.203e-43	169.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
CMS3_k127_132210_0	886293.Sinac_7479	1.078e-91	339.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
CMS3_k127_132210_3	1249975.JQLP01000005_gene2506	6.667e-21	103.0	COG1357@1|root,COG1361@1|root,COG1520@1|root,COG2304@1|root,COG2911@1|root,COG1357@2|Bacteria,COG1361@2|Bacteria,COG1520@2|Bacteria,COG2304@2|Bacteria,COG2911@2|Bacteria,4NMB8@976|Bacteroidetes,1IJKA@117743|Flavobacteriia	976|Bacteroidetes	M	Pfam C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,HYR,SdrD_B
CMS3_k127_1324453_1	1028800.RG540_CH20320	3.021e-07	61.0	COG1595@1|root,COG1595@2|Bacteria,1RKMN@1224|Proteobacteria,2U9GS@28211|Alphaproteobacteria,4BDTH@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1324453_0	478741.JAFS01000001_gene1542	2.267e-11	72.0	COG0457@1|root,COG0457@2|Bacteria,46SWY@74201|Verrucomicrobia	74201|Verrucomicrobia	V	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4062,NB-ARC,TPR_12,TPR_7
CMS3_k127_1324493_0	886293.Sinac_2761	1.093e-114	408.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IYTQ@203682|Planctomycetes	203682|Planctomycetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16
CMS3_k127_1324493_1	886293.Sinac_7484	8.017e-59	217.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1324493_2	1117314.PCIT_05609	4.733e-20	103.0	COG5295@1|root,COG5295@2|Bacteria,1N8QZ@1224|Proteobacteria	1224|Proteobacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_132614_0	1121468.AUBR01000024_gene3048	1.212e-108	359.0	COG0183@1|root,COG0183@2|Bacteria,1UZXX@1239|Firmicutes,249SJ@186801|Clostridia	186801|Clostridia	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_1330854_0	526227.Mesil_1947	0.0	1259.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1WIRD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Vitamin B12 dependent methionine synthase activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
CMS3_k127_1330854_1	1121013.P873_00640	6.251e-38	149.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,1S0IJ@1236|Gammaproteobacteria,1X3BN@135614|Xanthomonadales	135614|Xanthomonadales	KQ	ArsR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,Methyltransf_11
CMS3_k127_1341064_2	543632.JOJL01000051_gene6534	5.364e-28	130.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4D8RB@85008|Micromonosporales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_1341064_0	1267534.KB906755_gene4691	4.078e-53	200.0	COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria	57723|Acidobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_1341064_1	1343739.PAP_04080	1.798e-49	185.0	COG1297@1|root,arCOG04807@2157|Archaea,2Y2AA@28890|Euryarchaeota,243VV@183968|Thermococci	183968|Thermococci	P	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
CMS3_k127_1346998_1	334545.CCMG01000008_gene726	1.274e-97	326.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,2U050@28211|Alphaproteobacteria,47FW5@766|Rickettsiales	766|Rickettsiales	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS3_k127_1346998_0	243164.DET0787	1.012e-176	567.0	COG0423@1|root,COG0423@2|Bacteria,2G62M@200795|Chloroflexi,34D2R@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
CMS3_k127_1346998_4	1195236.CTER_0559	7.537e-14	86.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia,3WIWU@541000|Ruminococcaceae	186801|Clostridia	O	Subtilase family	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,LRR_5,PPC,Peptidase_S8
CMS3_k127_1346998_2	404589.Anae109_2478	6.373e-82	283.0	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,4307A@68525|delta/epsilon subdivisions,2WV7X@28221|Deltaproteobacteria,2YVIM@29|Myxococcales	28221|Deltaproteobacteria	G	Inositol monophosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Inositol_P
CMS3_k127_1348163_1	270374.MELB17_14361	1.115e-82	287.0	COG0726@1|root,COG0726@2|Bacteria,1MX6K@1224|Proteobacteria,1RYP1@1236|Gammaproteobacteria,464GV@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Lipopolysaccharide biosynthesis protein	walW	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1348163_0	1288826.MSNKSG1_06943	1.348e-243	782.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria,469ZI@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	carbamoyl transferase, NodU family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS3_k127_1352159_2	1123237.Salmuc_02359	3.186e-05	57.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG1520 FOG WD40-like repeat	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
CMS3_k127_1352159_1	502025.Hoch_3438	1.685e-28	120.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2WT56@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	RNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS3_k127_1352159_0	1122918.KB907280_gene266	3.545e-172	552.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,4HAKI@91061|Bacilli,26REN@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
CMS3_k127_1353165_0	314230.DSM3645_06374	8.828e-148	506.0	COG1674@1|root,COG1674@2|Bacteria,2IXHF@203682|Planctomycetes	203682|Planctomycetes	D	COG1674 DNA segregation ATPase FtsK SpoIIIE and related	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
CMS3_k127_1358572_3	497321.C664_04067	1.799e-39	151.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VMHS@28216|Betaproteobacteria,2KUQ2@206389|Rhodocyclales	206389|Rhodocyclales	I	Belongs to the thiolase family	fadA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_1358572_0	1056512.D515_00717	1.202e-133	460.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1XV3W@135623|Vibrionales	135623|Vibrionales	I	Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities	fadJ	GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
CMS3_k127_1358572_4	485917.Phep_0489	2.465e-16	90.0	COG0760@1|root,COG0760@2|Bacteria,4NEW0@976|Bacteroidetes,1IVH2@117747|Sphingobacteriia	976|Bacteroidetes	M	peptidylprolyl isomerase	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N_3
CMS3_k127_1358572_2	641491.DND132_0782	1.228e-53	203.0	COG0517@1|root,COG1208@1|root,COG0517@2|Bacteria,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,42MX5@68525|delta/epsilon subdivisions,2X5IA@28221|Deltaproteobacteria,2MGRF@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,NTP_transferase
CMS3_k127_1358572_1	671143.DAMO_0292	7.222e-66	242.0	COG0438@1|root,COG3064@1|root,COG0438@2|Bacteria,COG3064@2|Bacteria,2NR6D@2323|unclassified Bacteria	2|Bacteria	M	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,Radical_SAM,SPASM
CMS3_k127_1363267_0	1187851.A33M_3732	1.084e-202	642.0	COG0031@1|root,COG0031@2|Bacteria,1QQKZ@1224|Proteobacteria,2TUZQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
CMS3_k127_1363267_2	1187851.A33M_3731	2.45e-93	323.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	-	-	2.5.1.76,4.2.3.1	ko:K01733,ko:K15527	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,PALP
CMS3_k127_1363267_1	502025.Hoch_3413	2.431e-107	358.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,42M1Y@68525|delta/epsilon subdivisions,2WP4Z@28221|Deltaproteobacteria,2YU7V@29|Myxococcales	28221|Deltaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.1.53,3.5.1.6	ko:K01431,ko:K12251	ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100	M00046	R00905,R01152,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
CMS3_k127_1394958_0	1395513.P343_15415	0.0009645	43.0	COG3797@1|root,COG3797@2|Bacteria,1V4KG@1239|Firmicutes,4HIGT@91061|Bacilli	91061|Bacilli	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
CMS3_k127_1395078_0	1366050.N234_23380	6.733e-45	167.0	COG5649@1|root,COG5649@2|Bacteria,1RDDG@1224|Proteobacteria,2W0C7@28216|Betaproteobacteria,1KD98@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
CMS3_k127_1397942_0	886293.Sinac_5694	3.71e-47	189.0	COG1807@1|root,COG1807@2|Bacteria,2IZFZ@203682|Planctomycetes	203682|Planctomycetes	M	Tetratricopeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_1397942_1	439235.Dalk_0035	2.296e-35	144.0	2F8C0@1|root,340R0@2|Bacteria,1NZ9S@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1397942_3	439235.Dalk_0034	1.465e-15	92.0	2FDDQ@1|root,345FE@2|Bacteria,1P0YF@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1397942_2	1198452.Jab_1c13090	6.439e-19	103.0	2FDDQ@1|root,345FE@2|Bacteria,1P0YF@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1404905_3	1085623.GNIT_3572	3.088e-15	90.0	COG1404@1|root,COG5183@1|root,COG1404@2|Bacteria,COG5183@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,46BFY@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Peptidase inhibitor I9	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,Peptidase_S8,SLH
CMS3_k127_1404905_2	1122176.KB903533_gene2325	1.918e-17	85.0	COG3245@1|root,COG3245@2|Bacteria,4NRNS@976|Bacteroidetes,1IZF9@117747|Sphingobacteriia	976|Bacteroidetes	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1404905_0	1296415.JACC01000006_gene1509	1.735e-71	257.0	COG2960@1|root,COG2960@2|Bacteria,4NI9S@976|Bacteroidetes,1ICN0@117743|Flavobacteriia,2YKN6@290174|Aquimarina	976|Bacteroidetes	M	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1404905_4	1121451.DESAM_21375	7.242e-15	85.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2M9X5@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23
CMS3_k127_1404905_1	700598.Niako_5150	6.545e-23	110.0	COG2010@1|root,COG2010@2|Bacteria,4NRFW@976|Bacteroidetes,1IU4G@117747|Sphingobacteriia	976|Bacteroidetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
CMS3_k127_140504_1	446470.Snas_5715	2.394e-14	81.0	COG3540@1|root,COG3540@2|Bacteria,2GJCI@201174|Actinobacteria	201174|Actinobacteria	P	alkaline phosphatase	phoD	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
CMS3_k127_140504_0	502025.Hoch_3462	6.877e-50	195.0	COG2357@1|root,COG2357@2|Bacteria,1QYWE@1224|Proteobacteria,432GG@68525|delta/epsilon subdivisions,2WY52@28221|Deltaproteobacteria,2Z0Y8@29|Myxococcales	28221|Deltaproteobacteria	S	RelA SpoT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1405297_1	886293.Sinac_4894	6.91e-05	53.0	COG1595@1|root,COG1595@2|Bacteria,2J3UT@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1405297_2	1408444.JHYC01000013_gene2473	8.707e-05	52.0	2BNP9@1|root,32HCB@2|Bacteria,1QBYA@1224|Proteobacteria,1T7JI@1236|Gammaproteobacteria,1JFGD@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1405297_0	204669.Acid345_1475	1.697e-35	149.0	COG0436@1|root,COG0436@2|Bacteria,3Y5AV@57723|Acidobacteria,2JJXH@204432|Acidobacteriia	204432|Acidobacteriia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS3_k127_1405377_0	215803.DB30_6945	6.492e-13	72.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42QVZ@68525|delta/epsilon subdivisions,2WMVN@28221|Deltaproteobacteria,2YUQR@29|Myxococcales	28221|Deltaproteobacteria	S	Vault protein inter-alpha-trypsin domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
CMS3_k127_1407380_1	9305.ENSSHAP00000021188	6.478e-11	75.0	COG2304@1|root,2QPS2@2759|Eukaryota,38C6V@33154|Opisthokonta,3BE0X@33208|Metazoa,3CW49@33213|Bilateria,48A1Z@7711|Chordata,49623@7742|Vertebrata,3J7IP@40674|Mammalia,4JZFS@9263|Metatheria	33208|Metazoa	S	Inter-alpha-trypsin inhibitor heavy chain 2	ITIH2	GO:0003674,GO:0004857,GO:0004866,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010466,GO:0010605,GO:0010951,GO:0012505,GO:0019222,GO:0019538,GO:0030162,GO:0030234,GO:0030414,GO:0031323,GO:0031324,GO:0031974,GO:0032268,GO:0032269,GO:0036211,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043687,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0098772,GO:1901564	-	ko:K19015	-	-	-	-	ko00000,ko00536	-	-	-	ITI_HC_C,VIT,VWA
CMS3_k127_1407380_0	1129794.C427_1223	2.328e-119	415.0	COG2706@1|root,COG3391@1|root,COG3637@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,COG3637@2|Bacteria,1QWRQ@1224|Proteobacteria,1T4S3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1412320_0	414684.RC1_1865	6.331e-225	719.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria,2JP9U@204441|Rhodospirillales	204441|Rhodospirillales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
CMS3_k127_1417704_0	1384484.AEQU_1632	1.584e-51	207.0	COG2265@1|root,COG2265@2|Bacteria,2GP90@201174|Actinobacteria,4CUBH@84998|Coriobacteriia	84998|Coriobacteriia	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_U5-meth_tr
CMS3_k127_1417704_1	944564.HMPREF9200_0185	1.348e-09	69.0	COG1293@1|root,COG1293@2|Bacteria,1TQ8A@1239|Firmicutes,4H3BF@909932|Negativicutes	909932|Negativicutes	K	Fibronectin-binding protein A	FbpA	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
CMS3_k127_1417714_1	595460.RRSWK_03230	1.279e-13	82.0	2E71C@1|root,331K1@2|Bacteria,2J130@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1417714_0	502025.Hoch_1870	2.218e-80	274.0	COG3303@1|root,COG3303@2|Bacteria,1QXPE@1224|Proteobacteria	1224|Proteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	cbcM	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
CMS3_k127_1419010_3	105422.BBPM01000064_gene542	1.609e-18	95.0	2EEXH@1|root,338QV@2|Bacteria,2ICQN@201174|Actinobacteria,2NM2T@228398|Streptacidiphilus	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87,PMT_2
CMS3_k127_1419010_0	1234364.AMSF01000013_gene666	7.393e-178	571.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1X3PI@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
CMS3_k127_1419010_1	383372.Rcas_1550	7.233e-123	401.0	COG0115@1|root,COG0115@2|Bacteria,2G6AX@200795|Chloroflexi,3753Z@32061|Chloroflexia	32061|Chloroflexia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CMS3_k127_1419010_2	1123059.KB823012_gene2102	1.996e-36	156.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria,43WHW@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
CMS3_k127_1421019_2	314254.OA2633_08389	4.488e-11	68.0	COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MUDC@1224|Proteobacteria,2TQWS@28211|Alphaproteobacteria,43WRR@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,Homoserine_dh,NAD_binding_3
CMS3_k127_1421019_1	380358.XALC_2186	5.575e-68	246.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RXCB@1236|Gammaproteobacteria,1X4WJ@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the AB hydrolase superfamily. MetX family	metXS	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
CMS3_k127_1421019_0	1121878.AUGL01000001_gene239	7.52e-158	521.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3939,iBWG_1329.BWG_3608,iECDH10B_1368.ECDH10B_4128,iECDH1ME8569_1439.ECDH1ME8569_3808,iETEC_1333.ETEC_4208,iEcDH1_1363.EcDH1_4046,iEcHS_1320.EcHS_A4172,iEcolC_1368.EcolC_4076,iJO1366.b3939,iJR904.b3939,iUMNK88_1353.UMNK88_4777,iUTI89_1310.UTI89_C4524,iY75_1357.Y75_RS17365	Cys_Met_Meta_PP
CMS3_k127_1421019_3	886293.Sinac_0747	1.126e-08	64.0	COG1826@1|root,COG1826@2|Bacteria,2J14F@203682|Planctomycetes	203682|Planctomycetes	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
CMS3_k127_1438416_2	1235803.C825_02312	7.995e-08	64.0	2CB8C@1|root,33T5I@2|Bacteria,4P0N1@976|Bacteroidetes,2FX4B@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1438416_0	1396141.BATP01000023_gene713	9.95e-313	998.0	COG3408@1|root,COG4412@1|root,COG3408@2|Bacteria,COG4412@2|Bacteria,46XDF@74201|Verrucomicrobia,2IVJ2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1438416_1	530564.Psta_1259	1.555e-107	362.0	COG5555@1|root,COG5555@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS3_k127_1447453_1	756272.Plabr_4157	4.506e-162	533.0	COG3119@1|root,COG3119@2|Bacteria,2IXWN@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_1447453_0	886293.Sinac_2769	2.556e-190	610.0	COG4102@1|root,COG4102@2|Bacteria,2IY1A@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_1447453_2	530564.Psta_4049	9.151e-37	141.0	COG2010@1|root,COG2010@2|Bacteria,2IX85@203682|Planctomycetes	203682|Planctomycetes	C	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PSCyt1,PSCyt2,PSD1
CMS3_k127_1449047_5	484770.UFO1_2248	4.234e-07	61.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4H2AT@909932|Negativicutes	909932|Negativicutes	NU	Type II IV secretion system protein	epsE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
CMS3_k127_1449047_3	1123312.KB904567_gene2207	1.346e-44	178.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli	91061|Bacilli	KLT	serine threonine protein kinase	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS3_k127_1449047_0	323848.Nmul_A0525	8.129e-225	713.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,371KX@32003|Nitrosomonadales	28216|Betaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
CMS3_k127_1449047_4	388051.AUFE01000001_gene2080	2.655e-13	77.0	COG1881@1|root,COG1881@2|Bacteria,1N7JI@1224|Proteobacteria,2W2HZ@28216|Betaproteobacteria,1K75V@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
CMS3_k127_1449047_1	329726.AM1_2452	1.575e-97	351.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1G335@1117|Cyanobacteria	1117|Cyanobacteria	T	SMART Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
CMS3_k127_1449047_2	1144275.COCOR_06778	1.463e-91	321.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1R8BD@1224|Proteobacteria,43AIE@68525|delta/epsilon subdivisions,2X5YP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc
CMS3_k127_1456010_0	314230.DSM3645_20627	8.142e-134	441.0	COG1520@1|root,COG1520@2|Bacteria,2IWR8@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_1456010_1	1210884.HG799469_gene14163	9.644e-115	381.0	COG0666@1|root,COG1520@1|root,COG0666@2|Bacteria,COG1520@2|Bacteria,2J2A4@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS3_k127_1460149_2	118163.Ple7327_4332	2.925e-22	110.0	COG0793@1|root,COG0793@2|Bacteria,1G30Q@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Peptidase family S41	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41,Tricorn_C1
CMS3_k127_1460149_0	1123508.JH636449_gene7349	1.273e-65	257.0	COG0515@1|root,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_1460149_1	1168034.FH5T_00235	1.016e-60	218.0	COG0176@1|root,COG0176@2|Bacteria,4P1X0@976|Bacteroidetes,2FX3H@200643|Bacteroidia	976|Bacteroidetes	G	Transaldolase/Fructose-6-phosphate aldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
CMS3_k127_1461046_3	1297742.A176_03535	4.944e-23	116.0	COG0457@1|root,COG0457@2|Bacteria,1Q2H1@1224|Proteobacteria,4383J@68525|delta/epsilon subdivisions,2X3DM@28221|Deltaproteobacteria,2YVKC@29|Myxococcales	28221|Deltaproteobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,DUF3858,TPR_16,TPR_19
CMS3_k127_1461046_0	290397.Adeh_0237	3.491e-100	367.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,1R5BE@1224|Proteobacteria,4339F@68525|delta/epsilon subdivisions,2WYFR@28221|Deltaproteobacteria,2YTXM@29|Myxococcales	28221|Deltaproteobacteria	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,DUF3858,TPR_16,TPR_19,TPR_8,Transglut_core
CMS3_k127_1461046_1	314345.SPV1_03478	1.311e-96	323.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase type 11	arsM	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_31
CMS3_k127_1461046_2	118168.MC7420_6957	7.676e-87	293.0	COG0471@1|root,COG0471@2|Bacteria,1G5AP@1117|Cyanobacteria,1HCDN@1150|Oscillatoriales	1117|Cyanobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
CMS3_k127_1461955_1	1123070.KB899247_gene1533	2.173e-35	141.0	COG3639@1|root,COG3639@2|Bacteria	2|Bacteria	P	organic phosphonate transmembrane transporter activity	phnE	-	3.6.1.63	ko:K02042,ko:K06162	ko00440,ko02010,map00440,map02010	M00223	R10186	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	BPD_transp_1
CMS3_k127_1461955_0	867845.KI911784_gene2277	5.564e-97	343.0	COG0457@1|root,COG1404@1|root,COG3055@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,COG3055@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
CMS3_k127_1469208_0	1232666.JANE01000027_gene1414	1.096e-82	299.0	COG1164@1|root,COG1164@2|Bacteria,1TPV4@1239|Firmicutes,4HAJJ@91061|Bacilli,4GXTG@90964|Staphylococcaceae	91061|Bacilli	E	Oligoendopeptidase F	pepF	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3
CMS3_k127_1469208_1	530564.Psta_0956	1.698e-58	213.0	COG0584@1|root,COG0584@2|Bacteria,2IZ1A@203682|Planctomycetes	203682|Planctomycetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS3_k127_1469208_2	713586.KB900536_gene499	7.161e-19	87.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1WW0I@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
CMS3_k127_1478351_2	1122176.KB903565_gene3359	1.521e-10	71.0	COG4102@1|root,COG4102@2|Bacteria,4NFFC@976|Bacteroidetes,1IQCH@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_1478351_0	1229780.BN381_150112	7.867e-86	299.0	COG1283@1|root,COG1283@2|Bacteria,2IAMX@201174|Actinobacteria	201174|Actinobacteria	P	Na+/Pi-cotransporter	nptA	-	-	ko:K03324,ko:K14683	-	-	-	-	ko00000,ko02000,ko04147	2.A.58.1,2.A.58.2	-	-	Na_Pi_cotrans
CMS3_k127_1478351_1	232346.JHQL01000001_gene2477	1.184e-19	95.0	COG0704@1|root,COG0704@2|Bacteria,1NRGK@1224|Proteobacteria,1SMQP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	PhoU domain	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
CMS3_k127_1479685_0	391625.PPSIR1_41779	1.618e-132	447.0	COG3303@1|root,COG3303@2|Bacteria,1QX6Q@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1
CMS3_k127_1479685_1	96561.Dole_0127	8.703e-29	117.0	2DNRM@1|root,32YT2@2|Bacteria,1N8BS@1224|Proteobacteria,42XIM@68525|delta/epsilon subdivisions,2WTAT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
CMS3_k127_1479685_3	1187851.A33M_0936	9.092e-25	105.0	2C5EY@1|root,32YQJ@2|Bacteria,1N8K7@1224|Proteobacteria,2UGJ4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
CMS3_k127_1489293_0	323848.Nmul_A1873	3.13e-63	225.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,2VJTJ@28216|Betaproteobacteria,372KR@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Belongs to the MtfA family	mtfA	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
CMS3_k127_1489293_1	344747.PM8797T_09059	1.052e-52	193.0	COG1621@1|root,COG1621@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 32 family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,HTH_18
CMS3_k127_149521_8	1123368.AUIS01000019_gene1220	3.111e-16	81.0	COG0662@1|root,COG0662@2|Bacteria,1N7Q4@1224|Proteobacteria,1SEVR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_149521_5	595460.RRSWK_03955	1.794e-34	148.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,DUF4241
CMS3_k127_149521_0	521674.Plim_3672	4.268e-99	339.0	2BZ6M@1|root,2Z7HW@2|Bacteria,2IXV4@203682|Planctomycetes	203682|Planctomycetes	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS3_k127_149521_4	886293.Sinac_3470	2.968e-52	203.0	COG2194@1|root,COG2194@2|Bacteria,2J364@203682|Planctomycetes	203682|Planctomycetes	S	sulfuric ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_149521_3	886293.Sinac_3471	1.652e-52	200.0	COG2194@1|root,COG2194@2|Bacteria,2J38R@203682|Planctomycetes	203682|Planctomycetes	S	sulfuric ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_149521_7	1142394.PSMK_p00290	1.918e-18	97.0	29XVD@1|root,30JMP@2|Bacteria,2J4D9@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_149521_1	134676.ACPL_2556	7.793e-60	216.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS3_k127_149521_9	314230.DSM3645_16645	2.08e-08	64.0	COG1595@1|root,COG1595@2|Bacteria,2J0K1@203682|Planctomycetes	203682|Planctomycetes	K	TIGRFAM RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	-
CMS3_k127_149521_2	595460.RRSWK_02101	1.812e-55	220.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,WD40
CMS3_k127_1496046_3	240016.ABIZ01000001_gene1539	8.18e-29	122.0	COG1520@1|root,COG1520@2|Bacteria,46TV4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_1496046_1	391625.PPSIR1_41164	7.122e-123	410.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2YUII@29|Myxococcales	28221|Deltaproteobacteria	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS3_k127_1496046_0	497964.CfE428DRAFT_0160	3.224e-177	574.0	COG1657@1|root,COG1657@2|Bacteria,46UEC@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Squalene-hopene cyclase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans,SQHop_cyclase_C
CMS3_k127_1496046_2	485913.Krac_8944	1.814e-43	162.0	COG0745@1|root,COG0745@2|Bacteria,2G8GK@200795|Chloroflexi	200795|Chloroflexi	T	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_1497588_0	930166.CD58_21630	8.85e-119	398.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	-	-	2.5.1.48,4.4.1.1,4.4.1.2,4.4.1.8	ko:K01739,ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00609	R00782,R00999,R01001,R01283,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00487,RC00488,RC00710,RC01245,RC02303,RC02814,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
CMS3_k127_1497588_1	1079986.JH164847_gene1705	1.212e-50	190.0	COG1180@1|root,COG1180@2|Bacteria	2|Bacteria	C	glycyl-radical enzyme activating activity	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS3_k127_150594_1	1229204.AMYY01000011_gene155	6.995e-80	293.0	COG2304@1|root,COG2304@2|Bacteria,1N4IM@1224|Proteobacteria,2U389@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
CMS3_k127_150594_0	1515746.HR45_00385	5.908e-84	288.0	COG1721@1|root,COG1721@2|Bacteria,1MWPG@1224|Proteobacteria,1SJ2U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_1514996_0	7425.NV17664-PA	1.309e-19	101.0	COG0457@1|root,KOG1124@2759|Eukaryota,38CY4@33154|Opisthokonta,3BDZ9@33208|Metazoa,3CW1H@33213|Bilateria,41VA9@6656|Arthropoda,3SKNK@50557|Insecta,46GGS@7399|Hymenoptera	33208|Metazoa	S	Transmembrane and TPR repeat-containing protein	TMTC2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0008150,GO:0012505,GO:0016020,GO:0031984,GO:0042175,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0048878,GO:0050801,GO:0055065,GO:0055074,GO:0055080,GO:0065007,GO:0065008,GO:0072507,GO:0098771,GO:0098827	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_1,TPR_16,TPR_2,TPR_8
CMS3_k127_1521425_0	266264.Rmet_5011	3.507e-203	642.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VHC1@28216|Betaproteobacteria,1K09M@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	1.16.1.1	ko:K00520,ko:K21739	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
CMS3_k127_1521425_1	1515746.HR45_08440	1.756e-104	357.0	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,1RNG8@1236|Gammaproteobacteria,2QAIW@267890|Shewanellaceae	1236|Gammaproteobacteria	P	Belongs to the alkaline phosphatase family	phoA	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
CMS3_k127_1532171_2	1173027.Mic7113_1000	1.816e-21	108.0	2DM77@1|root,32UGC@2|Bacteria,1GBKJ@1117|Cyanobacteria,1HE7P@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1532171_1	324057.Pjdr2_1476	9.546e-88	302.0	COG1240@1|root,COG1240@2|Bacteria	2|Bacteria	H	magnesium chelatase activity	bchD	-	6.6.1.1	ko:K03404,ko:K07114	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
CMS3_k127_1532171_0	177439.DP1202	1.464e-164	527.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_1539_4	1120973.AQXL01000092_gene1180	1.913e-07	64.0	COG1807@1|root,COG1807@2|Bacteria,1TR0R@1239|Firmicutes,4HBI2@91061|Bacilli	91061|Bacilli	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_1539_1	768671.ThimaDRAFT_3712	5.251e-53	193.0	COG4636@1|root,COG4636@2|Bacteria,1NTAK@1224|Proteobacteria,1SM5Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
CMS3_k127_1539_2	1335757.SPICUR_03370	5.467e-43	180.0	COG3564@1|root,COG3564@2|Bacteria,1RGYH@1224|Proteobacteria,1S7GJ@1236|Gammaproteobacteria,1WYN7@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF779)	-	-	-	ko:K09959	-	-	-	-	ko00000	-	-	-	DUF779
CMS3_k127_1539_0	1242864.D187_009607	8.132e-263	822.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	-	ko:K00138	ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120	-	R00711	RC00047	ko00000,ko00001,ko01000	-	-	-	Aldedh
CMS3_k127_1539_3	1500894.JQNN01000001_gene3436	5.742e-10	69.0	2AFYI@1|root,3162A@2|Bacteria,1PWQU@1224|Proteobacteria,2WC9F@28216|Betaproteobacteria,4776G@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1546943_0	382464.ABSI01000011_gene2476	2.583e-82	284.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_1546943_1	1033802.SSPSH_002792	2.424e-42	171.0	COG1216@1|root,COG1216@2|Bacteria,1RHJA@1224|Proteobacteria,1SZHQ@1236|Gammaproteobacteria	1224|Proteobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
CMS3_k127_1549106_0	269797.Mbar_A1242	2.721e-07	64.0	COG3291@1|root,COG3391@1|root,arCOG02507@2157|Archaea,arCOG02510@2157|Archaea,arCOG02562@2157|Archaea,2XVNE@28890|Euryarchaeota	28890|Euryarchaeota	S	40-residue YVTN family beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
CMS3_k127_1549106_1	269797.Mbar_A1242	4.502e-07	63.0	COG3291@1|root,COG3391@1|root,arCOG02507@2157|Archaea,arCOG02510@2157|Archaea,arCOG02562@2157|Archaea,2XVNE@28890|Euryarchaeota	28890|Euryarchaeota	S	40-residue YVTN family beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
CMS3_k127_1559929_0	344747.PM8797T_27312	5.348e-227	722.0	COG3119@1|root,COG3119@2|Bacteria,2IYB8@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.13	ko:K01136	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00076,M00078	R07812,R07821	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4976,Sulfatase
CMS3_k127_1559929_1	479432.Sros_1440	3.018e-158	513.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4EJME@85012|Streptosporangiales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
CMS3_k127_1572084_1	518766.Rmar_0695	1.009e-45	175.0	COG0247@1|root,COG0247@2|Bacteria,4NIMP@976|Bacteroidetes	976|Bacteroidetes	C	Fe-S oxidoreductase	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
CMS3_k127_1572084_0	1121904.ARBP01000002_gene7044	4.04e-108	376.0	COG1139@1|root,COG1139@2|Bacteria,4NEBT@976|Bacteroidetes,47K0Z@768503|Cytophagia	976|Bacteroidetes	C	LUD domain	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
CMS3_k127_1572307_1	1123508.JH636452_gene7057	1.317e-35	144.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,2J2J0@203682|Planctomycetes	203682|Planctomycetes	S	Vault protein inter-alpha-trypsin domain	-	-	-	-	-	-	-	-	-	-	-	-	VIT,VWA_3
CMS3_k127_1572307_0	933262.AXAM01000056_gene3170	1.312e-88	301.0	COG0652@1|root,COG0652@2|Bacteria,1RENS@1224|Proteobacteria,42RIB@68525|delta/epsilon subdivisions,2X5WM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
CMS3_k127_1572307_2	1396418.BATQ01000065_gene1626	8.724e-32	136.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
CMS3_k127_1574167_2	1142394.PSMK_16220	1.358e-39	151.0	COG0436@1|root,COG0436@2|Bacteria,2IX5E@203682|Planctomycetes	203682|Planctomycetes	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_1574167_3	702437.HMPREF9432_01744	3.627e-29	129.0	COG0602@1|root,COG0602@2|Bacteria,1TQ58@1239|Firmicutes,4H3BM@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
CMS3_k127_1574167_0	247490.KSU1_B0239	9.606e-126	416.0	COG1160@1|root,COG1160@2|Bacteria,2IWXY@203682|Planctomycetes	203682|Planctomycetes	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
CMS3_k127_1574167_1	396588.Tgr7_0530	3.989e-110	366.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1WWWF@135613|Chromatiales	135613|Chromatiales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
CMS3_k127_1575008_2	159087.Daro_2982	4.411e-08	63.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria,2KVKZ@206389|Rhodocyclales	206389|Rhodocyclales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
CMS3_k127_1575008_3	749414.SBI_04631	0.0004985	53.0	COG0488@1|root,COG2319@1|root,COG0488@2|Bacteria,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria	201174|Actinobacteria	F	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC4_WD40,HTH_3,HTH_31,WD40
CMS3_k127_1575008_1	314345.SPV1_05168	9.769e-67	233.0	COG0590@1|root,COG0590@2|Bacteria,1RE8P@1224|Proteobacteria	1224|Proteobacteria	FJ	deaminase	cdd	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
CMS3_k127_1575008_0	756883.Halar_1112	3.055e-147	480.0	COG2233@1|root,arCOG02805@2157|Archaea	2157|Archaea	F	COG2233 Xanthine uracil permeases	-	-	-	ko:K02824,ko:K03458	-	-	-	-	ko00000,ko02000	2.A.40,2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
CMS3_k127_1576296_0	1403819.BATR01000027_gene887	5.869e-11	75.0	2DU8X@1|root,33PEA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1576296_1	1353531.AZNX01000001_gene2018	4.06e-10	73.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VEWM@28211|Alphaproteobacteria,4BNDN@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1576364_1	1380390.JIAT01000014_gene6208	1.889e-60	224.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,NB-ARC,Response_reg,TIR_2,TPR_10,TPR_12
CMS3_k127_1576364_2	290400.Jann_3673	4.217e-60	220.0	2DVSI@1|root,33WZN@2|Bacteria,1NK4P@1224|Proteobacteria,2UW3G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1576364_0	290400.Jann_3672	5.336e-139	458.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TRTJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
CMS3_k127_1576364_3	926550.CLDAP_12690	4.982e-38	148.0	COG3059@1|root,COG3059@2|Bacteria	2|Bacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF417,DoxX
CMS3_k127_1576364_4	215803.DB30_3173	3.898e-35	140.0	COG2373@1|root,COG2373@2|Bacteria,1QTCC@1224|Proteobacteria,437VK@68525|delta/epsilon subdivisions,2X356@28221|Deltaproteobacteria,2YUBE@29|Myxococcales	28221|Deltaproteobacteria	S	A-macroglobulin complement component	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,A2M_recep,Thiol-ester_cl
CMS3_k127_157956_5	1123393.KB891316_gene1871	1.056e-23	102.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2VHHC@28216|Betaproteobacteria,1KSYB@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Shikimate dehydrogenase substrate binding domain	-	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
CMS3_k127_157956_2	1210884.HG799462_gene8232	1.057e-136	448.0	COG2317@1|root,COG2317@2|Bacteria,2IXSU@203682|Planctomycetes	203682|Planctomycetes	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
CMS3_k127_157956_3	96561.Dole_1897	1.425e-136	440.0	COG1830@1|root,COG1830@2|Bacteria,1MWJW@1224|Proteobacteria,42PHA@68525|delta/epsilon subdivisions,2WKBX@28221|Deltaproteobacteria,2MK4V@213118|Desulfobacterales	28221|Deltaproteobacteria	G	DeoC/LacD family aldolase	-	-	2.3.1.245	ko:K08321	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	DeoC
CMS3_k127_157956_0	314230.DSM3645_10902	1.454e-147	493.0	COG0823@1|root,COG1506@1|root,COG4805@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,COG4805@2|Bacteria,2IY8M@203682|Planctomycetes	203682|Planctomycetes	E	Dipeptidyl peptidase IV (DPP IV)	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,DUF885,Peptidase_S9,VHL
CMS3_k127_157956_6	1541960.KQ78_01945	6.963e-08	55.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	nrdH	-	-	ko:K06191	-	-	-	-	ko00000	-	-	-	Glutaredoxin
CMS3_k127_157956_4	269796.Rru_A3125	1.124e-63	244.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2U43G@28211|Alphaproteobacteria,2JQ88@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_157956_1	1380394.JADL01000008_gene3672	5.205e-139	469.0	COG0451@1|root,COG0673@1|root,COG0451@2|Bacteria,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,2TQM1@28211|Alphaproteobacteria,2JUHP@204441|Rhodospirillales	204441|Rhodospirillales	GM	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_1595552_2	357808.RoseRS_2451	2.581e-06	61.0	COG4870@1|root,COG4932@1|root,COG5513@1|root,COG4870@2|Bacteria,COG4932@2|Bacteria,COG5513@2|Bacteria,2GA24@200795|Chloroflexi,377PH@32061|Chloroflexia	2|Bacteria	MO	Carboxypeptidase regulatory-like domain	-	-	3.4.22.15	ko:K01365,ko:K02030,ko:K14475	ko04140,ko04142,ko04145,ko04210,ko04612,ko05143,ko05205,ko05323,ko05418,map04140,map04142,map04145,map04210,map04612,map05143,map05205,map05323,map05418	M00236	-	-	ko00000,ko00001,ko00002,ko00537,ko01000,ko01002,ko02000,ko03110	3.A.1.3	-	-	CarboxypepD_reg,Inhibitor_I42,Peptidase_C1
CMS3_k127_1595552_0	13035.Dacsa_0240	2.418e-133	446.0	COG1132@1|root,COG1132@2|Bacteria,1G13C@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_1595552_1	111781.Lepto7376_0062	1.099e-10	66.0	COG3563@1|root,COG3563@2|Bacteria,1G9Y3@1117|Cyanobacteria	1117|Cyanobacteria	M	Capsule polysaccharide	-	-	-	-	-	-	-	-	-	-	-	-	Capsule_synth
CMS3_k127_1598326_3	313628.LNTAR_21595	1.412e-10	63.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS3_k127_1598326_2	1385514.N782_02870	9.549e-48	181.0	COG0640@1|root,COG0640@2|Bacteria,1VJ43@1239|Firmicutes,4HQM5@91061|Bacilli,2YAHB@289201|Pontibacillus	91061|Bacilli	K	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,HTH_20
CMS3_k127_1598326_0	1122137.AQXF01000007_gene3583	8.176e-153	504.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VF3C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21.2	-	-	SSF
CMS3_k127_1598326_1	243231.GSU1204	4.128e-82	292.0	COG0475@1|root,COG0490@1|root,COG1226@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WK23@28221|Deltaproteobacteria,43T1F@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
CMS3_k127_1599041_0	886293.Sinac_4025	7.019e-162	559.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,TPR_8,WD40
CMS3_k127_1599041_1	886293.Sinac_4026	1.433e-57	205.0	COG1595@1|root,COG1595@2|Bacteria,2IZ8A@203682|Planctomycetes	203682|Planctomycetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS3_k127_1610760_1	266117.Rxyl_2534	1.232e-14	87.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria	201174|Actinobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	acoC	-	2.3.1.12,2.3.1.168,2.3.1.61	ko:K00627,ko:K00658,ko:K09699	ko00010,ko00020,ko00280,ko00310,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00310,map00620,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00036,M00307	R00209,R02569,R02570,R02571,R02662,R03174,R04097,R08549,R10998	RC00004,RC02727,RC02742,RC02833,RC02857,RC02870	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CMS3_k127_1610760_2	65393.PCC7424_5775	3.906e-06	59.0	COG0110@1|root,COG0110@2|Bacteria,1GBCV@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Bacterial transferase hexapeptide (three repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
CMS3_k127_1610760_0	1122175.ATXU01000010_gene1562	1.526e-23	113.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	3.2.1.8,3.5.1.104	ko:K01181,ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	CBM9_1,CBM_4_9,Glyco_hydro_10,PEGA,Polysacc_deac_1,SLH
CMS3_k127_1636225_1	1123242.JH636434_gene5055	6.233e-92	327.0	COG3386@1|root,COG3386@2|Bacteria,2IXWY@203682|Planctomycetes	203682|Planctomycetes	G	gluconolactonase	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
CMS3_k127_1636225_0	344747.PM8797T_01104	1.866e-113	391.0	28JXN@1|root,2Z9N3@2|Bacteria,2IXIH@203682|Planctomycetes	203682|Planctomycetes	S	PFAM FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS3_k127_1650074_1	761193.Runsl_1323	7.321e-140	447.0	COG0673@1|root,COG0673@2|Bacteria,4NEJM@976|Bacteroidetes,47NS9@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_1650074_0	1047013.AQSP01000140_gene2467	3.274e-148	486.0	COG1473@1|root,COG1473@2|Bacteria,2NP7P@2323|unclassified Bacteria	2|Bacteria	S	Peptidase dimerisation domain	-	-	-	ko:K12941	-	-	-	-	ko00000,ko01002	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_1652436_0	886293.Sinac_0255	5.021e-20	106.0	COG4219@1|root,COG4932@1|root,COG4219@2|Bacteria,COG4932@2|Bacteria,2IZ9V@203682|Planctomycetes	203682|Planctomycetes	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
CMS3_k127_1652436_1	502025.Hoch_0971	2.46e-19	97.0	COG2227@1|root,COG2227@2|Bacteria,1QXTG@1224|Proteobacteria,43C5V@68525|delta/epsilon subdivisions,2X7G3@28221|Deltaproteobacteria,2Z2NP@29|Myxococcales	28221|Deltaproteobacteria	H	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_1654117_2	237368.SCABRO_02683	4.845e-12	76.0	COG1596@1|root,COG1596@2|Bacteria,2J059@203682|Planctomycetes	203682|Planctomycetes	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
CMS3_k127_1654117_0	1121346.KB899817_gene3226	7.78e-137	442.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,4HA3Y@91061|Bacilli,26RIV@186822|Paenibacillaceae	91061|Bacilli	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	spsJ	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
CMS3_k127_1654117_1	760568.Desku_0718	8.153e-63	226.0	COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia,261FK@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
CMS3_k127_1655901_0	324602.Caur_0649	2.507e-79	291.0	COG1404@1|root,COG4447@1|root,COG1404@2|Bacteria,COG4447@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
CMS3_k127_1655901_1	1249627.D779_2281	1.885e-69	245.0	COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,1RYT6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	N-formylglutamate amidohydrolase	hutG	-	3.5.1.68,3.5.3.8	ko:K01458,ko:K01479	ko00340,ko00630,ko01100,map00340,map00630,map01100	M00045	R00525,R02285	RC00165,RC00221,RC00323,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	FGase
CMS3_k127_1655901_2	1249627.D779_2280	4.218e-18	84.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1WWYZ@135613|Chromatiales	135613|Chromatiales	E	PFAM Gamma-glutamyltranspeptidase	-	-	-	-	-	-	-	-	-	-	-	-	G_glu_transpept
CMS3_k127_166175_0	32057.KB217478_gene3544	0.0009509	49.0	COG1413@1|root,COG1413@2|Bacteria,1GHRB@1117|Cyanobacteria,1HSJZ@1161|Nostocales	1117|Cyanobacteria	C	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
CMS3_k127_1662811_1	1313172.YM304_12480	8.337e-15	84.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1662811_0	1123508.JH636443_gene4732	6.559e-51	205.0	COG0515@1|root,COG0515@2|Bacteria,2J2C5@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_1663568_5	1396141.BATP01000022_gene394	3.243e-07	63.0	2A06M@1|root,30N9S@2|Bacteria,46XPI@74201|Verrucomicrobia,2IWBR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
CMS3_k127_1663568_4	1340493.JNIF01000003_gene1823	3.876e-23	104.0	COG1438@1|root,COG1438@2|Bacteria	2|Bacteria	K	arginine binding	argR	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
CMS3_k127_1663568_2	1158146.KB907121_gene875	6.876e-74	261.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,1WWVX@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
CMS3_k127_1663568_3	278963.ATWD01000001_gene4570	4.258e-40	161.0	COG0548@1|root,COG0548@2|Bacteria,3Y2IF@57723|Acidobacteria,2JIE8@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
CMS3_k127_1663568_1	1192759.AKIB01000040_gene3595	6.19e-88	306.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,2K0I4@204457|Sphingomonadales	204457|Sphingomonadales	E	acetylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_1663568_0	1047013.AQSP01000119_gene1309	1.099e-96	325.0	COG0078@1|root,COG0078@2|Bacteria,2NNWN@2323|unclassified Bacteria	2|Bacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS3_k127_1665332_0	85643.Tmz1t_2948	1.081e-86	291.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,2VSQQ@28216|Betaproteobacteria,2KXX8@206389|Rhodocyclales	206389|Rhodocyclales	I	BadF/BadG/BcrA/BcrD ATPase family	-	-	1.3.7.8	ko:K04115	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	BcrAD_BadFG
CMS3_k127_1665332_1	269799.Gmet_2059	1.066e-55	203.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,42QAM@68525|delta/epsilon subdivisions,2WM04@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_1665332_2	1125863.JAFN01000001_gene2436	1.748e-29	131.0	COG0454@1|root,COG0456@2|Bacteria,1N43K@1224|Proteobacteria,42VN3@68525|delta/epsilon subdivisions,2WRDJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_1667368_0	880073.Calab_1254	2.341e-56	211.0	COG2133@1|root,COG2866@1|root,COG2133@2|Bacteria,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	manA5	-	3.2.1.51,3.2.1.78	ko:K01206,ko:K01218	ko00051,ko00511,ko02024,map00051,map00511,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000,ko04147	-	GH26,GH29	-	Alpha_L_fucos,CHU_C,Glyco_hydro_26,PA14
CMS3_k127_1667368_2	1307759.JOMJ01000004_gene2463	1.489e-42	164.0	COG4885@1|root,COG4885@2|Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
CMS3_k127_1667368_3	1968.JOEV01000024_gene5588	6.015e-06	58.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS3_k127_1667368_1	344747.PM8797T_27689	1.169e-44	167.0	COG2905@1|root,COG2905@2|Bacteria,2J53V@203682|Planctomycetes	203682|Planctomycetes	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS3_k127_167158_5	1121385.AQXW01000004_gene2264	2.273e-06	59.0	COG1595@1|root,COG1595@2|Bacteria,2GM3E@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_167158_3	886293.Sinac_2556	1.45e-20	103.0	COG0526@1|root,COG1331@1|root,COG0526@2|Bacteria,COG1331@2|Bacteria,2J28Y@203682|Planctomycetes	203682|Planctomycetes	CO	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_167158_4	886293.Sinac_3998	4.718e-16	89.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
CMS3_k127_167158_1	1210884.HG799464_gene11097	1.003e-66	259.0	COG2010@1|root,COG2010@2|Bacteria,2IXIX@203682|Planctomycetes	203682|Planctomycetes	C	PFAM PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,PA14
CMS3_k127_167158_0	485917.Phep_0336	5.843e-113	383.0	COG2133@1|root,COG2133@2|Bacteria,4NI97@976|Bacteroidetes,1IWTQ@117747|Sphingobacteriia	976|Bacteroidetes	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
CMS3_k127_167158_2	264731.PRU_0011	2.14e-33	143.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
CMS3_k127_1683033_0	562970.Btus_2368	1.259e-113	379.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4H9YE@91061|Bacilli,278TC@186823|Alicyclobacillaceae	91061|Bacilli	C	Citrate synthase, C-terminal domain	citZ	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
CMS3_k127_1683033_4	391625.PPSIR1_30923	1.208e-36	148.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria	1224|Proteobacteria	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	iECIAI39_1322.ECIAI39_0052,iEcSMS35_1347.EcSMS35_0053,iJN746.PP_0399,iSDY_1059.SDY_0074	Metallophos
CMS3_k127_1683033_3	1123508.JH636439_gene1507	3.155e-60	216.0	COG0110@1|root,COG0110@2|Bacteria,2IZ7A@203682|Planctomycetes	203682|Planctomycetes	S	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.201	ko:K13018	ko00520,map00520	-	R10100	RC00004,RC00166	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,Hexapep
CMS3_k127_1683033_2	530564.Psta_1437	1.024e-65	238.0	COG0673@1|root,COG0673@2|Bacteria,2IXZN@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_1683033_1	1142394.PSMK_18740	5.81e-87	314.0	COG0399@1|root,COG0399@2|Bacteria,2IYSK@203682|Planctomycetes	203682|Planctomycetes	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS3_k127_1683033_5	926566.Terro_1263	1.151e-35	145.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
CMS3_k127_1683033_6	525367.HMPREF0556_11627	5.719e-27	114.0	COG0346@1|root,COG0346@2|Bacteria,1V6K3@1239|Firmicutes,4HJ7X@91061|Bacilli,26KFZ@186820|Listeriaceae	91061|Bacilli	E	Lactoylglutathione lyase	gloA	-	4.4.1.5	ko:K01759,ko:K15772	ko00620,ko02010,map00620,map02010	M00491	R02530	RC00004,RC00740	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	Glyoxalase
CMS3_k127_1683373_0	1122986.KB908324_gene800	2.046e-114	378.0	COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,2FM3F@200643|Bacteroidia	976|Bacteroidetes	M	Psort location CytoplasmicMembrane, score 10.00	algI	-	-	-	-	-	-	-	-	-	-	-	MBOAT
CMS3_k127_1683373_1	243090.RB2086	9.507e-11	74.0	COG0457@1|root,COG2755@1|root,COG0457@2|Bacteria,COG2755@2|Bacteria,2IXJ9@203682|Planctomycetes	2|Bacteria	E	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS3_k127_1683373_2	1121930.AQXG01000004_gene2980	9.606e-06	57.0	COG2755@1|root,COG2755@2|Bacteria,4NHX6@976|Bacteroidetes,1IVBP@117747|Sphingobacteriia	976|Bacteroidetes	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS3_k127_1686467_0	880073.Calab_2937	1.382e-127	428.0	COG0667@1|root,COG0667@2|Bacteria,2NPI2@2323|unclassified Bacteria	2|Bacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS3_k127_1686467_1	485913.Krac_4790	1.969e-48	190.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_1686467_2	493475.GARC_4265	2.913e-10	61.0	COG2931@1|root,COG2982@1|root,COG4733@1|root,COG2931@2|Bacteria,COG2982@2|Bacteria,COG4733@2|Bacteria,1MU7T@1224|Proteobacteria,1S1HJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,DUF4214,DUF4347,He_PIG,HemolysinCabind,PATR,VCBS
CMS3_k127_168723_6	246197.MXAN_1661	6.148e-07	62.0	COG1595@1|root,COG1595@2|Bacteria,1PD6I@1224|Proteobacteria,435EM@68525|delta/epsilon subdivisions,2X98N@28221|Deltaproteobacteria,2Z2MY@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_168723_0	1125863.JAFN01000001_gene2793	4.089e-201	662.0	COG2010@1|root,COG3258@1|root,COG2010@2|Bacteria,COG3258@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2WPS4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c	pcmF	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
CMS3_k127_168723_1	1125863.JAFN01000001_gene2794	2.765e-187	608.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WMNX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cytochrome b b6 domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
CMS3_k127_168723_3	1125863.JAFN01000001_gene2795	2.268e-33	139.0	COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42VKD@68525|delta/epsilon subdivisions,2WRHY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Rieske 2Fe-2S domain	pcmE	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
CMS3_k127_168723_2	1125863.JAFN01000001_gene2796	2.507e-173	567.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42PJ7@68525|delta/epsilon subdivisions,2WMEM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
CMS3_k127_168723_5	880073.Calab_0423	1.345e-10	74.0	COG0642@1|root,COG2205@2|Bacteria	880073.Calab_0423|-	T	PhoQ Sensor	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	-
CMS3_k127_168723_4	880073.Calab_2888	6.083e-12	78.0	COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,2NR0D@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	1.8.1.9	ko:K00384,ko:K07814,ko:K09763	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko02022	-	-	-	HD,Pyr_redox_2,Pyr_redox_3,Response_reg
CMS3_k127_1692562_0	661478.OP10G_0316	1.39e-57	217.0	2BZ4W@1|root,2Z7PQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1692562_2	1196835.A458_01200	0.0009162	51.0	28JMK@1|root,2Z9E3@2|Bacteria,1QSC2@1224|Proteobacteria,1S6D6@1236|Gammaproteobacteria,1Z2FI@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2868)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2868
CMS3_k127_1692562_1	880073.Calab_3284	1.964e-13	74.0	COG1680@1|root,COG1680@2|Bacteria,2NNSA@2323|unclassified Bacteria	2|Bacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
CMS3_k127_1693830_0	595494.Tola_1432	1.717e-121	404.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1Y403@135624|Aeromonadales	135624|Aeromonadales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CMS3_k127_1693830_4	1230341.MJ3_04729	5.813e-21	100.0	COG1610@1|root,COG1610@2|Bacteria,1V6F2@1239|Firmicutes,4HIQP@91061|Bacilli	91061|Bacilli	S	YqeY-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
CMS3_k127_1693830_3	944479.JQLX01000011_gene813	2.02e-23	113.0	COG0671@1|root,COG0671@2|Bacteria,1NDCB@1224|Proteobacteria,42W6H@68525|delta/epsilon subdivisions,2WREU@28221|Deltaproteobacteria,2M6UN@213113|Desulfurellales	28221|Deltaproteobacteria	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
CMS3_k127_1693830_1	404380.Gbem_3626	6.198e-84	292.0	COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,42MHQ@68525|delta/epsilon subdivisions,2WJAC@28221|Deltaproteobacteria,43U9E@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
CMS3_k127_1693830_2	414684.RC1_0990	1.391e-26	125.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,2JQMA@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,SSF
CMS3_k127_1718395_4	1123257.AUFV01000003_gene1244	2.324e-24	115.0	COG2067@1|root,COG2067@2|Bacteria,1RFDS@1224|Proteobacteria,1SBRG@1236|Gammaproteobacteria,1X6ZH@135614|Xanthomonadales	135614|Xanthomonadales	I	Protein of unknown function (DUF3187)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3187
CMS3_k127_1718395_3	502025.Hoch_5881	2.296e-54	201.0	2CAZH@1|root,2Z7RU@2|Bacteria,1RBDC@1224|Proteobacteria,42SC7@68525|delta/epsilon subdivisions,2WP8S@28221|Deltaproteobacteria,2Z0M1@29|Myxococcales	28221|Deltaproteobacteria	C	fumarate reductase) cytochrome b subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
CMS3_k127_1718395_0	316274.Haur_1733	7.983e-320	1001.0	COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi,374WX@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CMS3_k127_1718395_1	1123508.JH636439_gene1816	3.493e-107	359.0	COG0479@1|root,COG0479@2|Bacteria,2IX7J@203682|Planctomycetes	203682|Planctomycetes	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
CMS3_k127_1718395_5	795797.C497_11857	1.419e-06	61.0	COG1413@1|root,arCOG04653@2157|Archaea,2XUXY@28890|Euryarchaeota,23SVC@183963|Halobacteria	183963|Halobacteria	C	COG1413 FOG HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS3_k127_1718395_2	756272.Plabr_0106	3.416e-95	320.0	COG2010@1|root,COG2010@2|Bacteria,2IXIX@203682|Planctomycetes	203682|Planctomycetes	C	PFAM PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,DUF1080,PA14
CMS3_k127_1722102_1	879212.DespoDRAFT_02828	8.158e-79	273.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NG2@68525|delta/epsilon subdivisions,2WK33@28221|Deltaproteobacteria,2MPZT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
CMS3_k127_1722102_0	443143.GM18_2768	1.105e-117	396.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,42X93@68525|delta/epsilon subdivisions,2WSXR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
CMS3_k127_1723602_1	1123393.KB891326_gene35	2.19e-34	138.0	COG0491@1|root,COG0491@2|Bacteria,1NMU0@1224|Proteobacteria,2WBU4@28216|Betaproteobacteria,1KSJV@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1723602_0	1123242.JH636434_gene4399	5.89e-184	585.0	COG1413@1|root,COG1413@2|Bacteria,2IX4C@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS3_k127_1734012_0	555779.Dthio_PD1478	2.273e-39	151.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria,2MAU1@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS3_k127_1734012_1	1449126.JQKL01000036_gene1950	6.419e-29	133.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind
CMS3_k127_1734012_3	1029824.AFID01000001_gene2011	2.658e-16	91.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,1W8FQ@1268|Micrococcaceae	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS3_k127_1734012_2	1219045.BV98_000175	2.926e-24	111.0	COG4888@1|root,COG4888@2|Bacteria	2|Bacteria	G	ASPIC UnbV domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,UnbV_ASPIC,VCBS
CMS3_k127_1749872_4	7260.FBpp0253589	1.254e-16	90.0	COG0457@1|root,KOG1124@2759|Eukaryota,38CY4@33154|Opisthokonta,3BDZ9@33208|Metazoa,3CW1H@33213|Bilateria,41VA9@6656|Arthropoda,3SKNK@50557|Insecta,44XMA@7147|Diptera,45QJ2@7214|Drosophilidae	33208|Metazoa	S	Domain of unknown function (DUF1736)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1736,PMT_2,TPR_1,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8
CMS3_k127_1749872_0	1379698.RBG1_1C00001G1403	1.593e-123	416.0	COG2133@1|root,COG2133@2|Bacteria,2NNSP@2323|unclassified Bacteria	2|Bacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
CMS3_k127_1749872_1	926550.CLDAP_38230	2.71e-123	424.0	COG1171@1|root,COG1171@2|Bacteria,2G69F@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
CMS3_k127_1749872_3	1122134.KB893650_gene1141	3.738e-84	291.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1XHSS@135619|Oceanospirillales	135619|Oceanospirillales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_1749872_2	523791.Kkor_1780	2.853e-91	319.0	COG0842@1|root,COG1511@1|root,COG0842@2|Bacteria,COG1511@2|Bacteria,1PM1H@1224|Proteobacteria,1RUN8@1236|Gammaproteobacteria,1XQN3@135619|Oceanospirillales	135619|Oceanospirillales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
CMS3_k127_1753910_3	1123277.KB893182_gene4754	4.47e-21	97.0	COG3250@1|root,COG3250@2|Bacteria,4NEDP@976|Bacteroidetes,47JV2@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_2_N,SASA
CMS3_k127_1753910_2	471854.Dfer_2050	1.6e-32	144.0	COG2831@1|root,COG2931@1|root,COG2831@2|Bacteria,COG2931@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
CMS3_k127_1753910_0	756272.Plabr_3170	1.049e-85	300.0	COG3119@1|root,COG3119@2|Bacteria,2J2AM@203682|Planctomycetes	203682|Planctomycetes	P	Sulfatase	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
CMS3_k127_1753910_1	756272.Plabr_3209	1.37e-55	211.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS3_k127_1753910_4	745776.DGo_CA1648	3.419e-06	58.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	yfhR3	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,Peptidase_S9
CMS3_k127_1765438_4	1047013.AQSP01000101_gene609	2.639e-23	109.0	COG4447@1|root,COG4447@2|Bacteria,2NQN9@2323|unclassified Bacteria	2|Bacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	BNR,BNR_6,Sortilin-Vps10
CMS3_k127_1765438_3	1492738.FEM21_28300	6.809e-33	141.0	28K60@1|root,2Z9UH@2|Bacteria,4NHE6@976|Bacteroidetes,1IEXU@117743|Flavobacteriia,2NYKK@237|Flavobacterium	976|Bacteroidetes	S	Methane oxygenase PmoA	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
CMS3_k127_1765438_1	649638.Trad_1837	3.888e-104	352.0	COG4948@1|root,COG4948@2|Bacteria,1WMNA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Mandelate racemase muconate lactonizing enzyme	ykfB	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
CMS3_k127_1765438_0	382464.ABSI01000011_gene2896	1.816e-115	389.0	COG0673@1|root,COG0673@2|Bacteria,46UYM@74201|Verrucomicrobia,2IVG2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_1765438_2	1120965.AUBV01000010_gene2765	8.087e-62	220.0	COG2080@1|root,COG2080@2|Bacteria,4NM72@976|Bacteroidetes,47PA8@768503|Cytophagia	976|Bacteroidetes	C	2Fe-2S -binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CMS3_k127_1766890_1	279238.Saro_3035	3.236e-05	55.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2K04M@204457|Sphingomonadales	204457|Sphingomonadales	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_14,TPR_16,TPR_19,TPR_8
CMS3_k127_1766890_0	720555.BATR1942_10750	3.469e-29	130.0	COG0457@1|root,COG0705@1|root,COG0457@2|Bacteria,COG0705@2|Bacteria,1TQXT@1239|Firmicutes,4HCDF@91061|Bacilli,1ZBV7@1386|Bacillus	91061|Bacilli	O	membrane protein (homolog of Drosophila rhomboid)	gluP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,TPR_2,TPR_8
CMS3_k127_1770056_0	661478.OP10G_0324	1.862e-117	389.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS3_k127_1770056_1	62928.azo0278	5.192e-06	58.0	2EFNF@1|root,339EK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1770056_2	1068978.AMETH_4221	9.483e-05	55.0	COG0477@1|root,COG4932@1|root,COG0477@2|Bacteria,COG4932@2|Bacteria,2GJSC@201174|Actinobacteria,4DYJP@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,MFS_1
CMS3_k127_1775884_3	1123242.JH636435_gene1455	9.589e-17	90.0	COG0265@1|root,COG0526@1|root,COG0265@2|Bacteria,COG0526@2|Bacteria,2J07Q@203682|Planctomycetes	203682|Planctomycetes	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_1775884_1	886293.Sinac_1102	2.716e-26	110.0	COG0526@1|root,COG0526@2|Bacteria,2J07Q@203682|Planctomycetes	203682|Planctomycetes	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_1775884_4	28072.Nos7524_2609	1.079e-06	55.0	COG1716@1|root,COG1716@2|Bacteria,1G79Z@1117|Cyanobacteria,1HJKQ@1161|Nostocales	1117|Cyanobacteria	T	(FHA) domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
CMS3_k127_1775884_0	234267.Acid_1856	4.508e-64	242.0	COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y45M@57723|Acidobacteria	57723|Acidobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_2,SpoIIE
CMS3_k127_1775884_2	204669.Acid345_4391	9.577e-23	103.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	57723|Acidobacteria	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
CMS3_k127_1784332_2	216596.RL1335	3.472e-33	143.0	COG0477@1|root,COG2814@2|Bacteria,1MUBP@1224|Proteobacteria,2TQVH@28211|Alphaproteobacteria,4B8CF@82115|Rhizobiaceae	28211|Alphaproteobacteria	EGP	MFS_1 like family	mdtG	-	-	ko:K08161	-	-	-	-	ko00000,ko02000	2.A.1.2.20	-	-	MFS_1,Sugar_tr
CMS3_k127_1784332_1	1121033.AUCF01000008_gene5688	5.124e-71	250.0	COG0625@1|root,COG0625@2|Bacteria,1PHM1@1224|Proteobacteria,2TTQZ@28211|Alphaproteobacteria,2JRW7@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_2,GST_N_3
CMS3_k127_1784332_0	1499967.BAYZ01000104_gene3700	4.341e-165	550.0	COG1082@1|root,COG3291@1|root,COG1082@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	5.3.99.11	ko:K06606	ko00562,ko01120,map00562,map01120	-	R09952	RC01513	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2,UnbV_ASPIC,VCBS
CMS3_k127_1785142_0	1117379.BABA_23183	3.777e-120	400.0	COG0620@1|root,COG0620@2|Bacteria,1TP2H@1239|Firmicutes,4H9QC@91061|Bacilli,1ZBI7@1386|Bacillus	91061|Bacilli	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
CMS3_k127_1785142_1	1131730.BAVI_15667	2.503e-63	226.0	COG0425@1|root,COG1765@1|root,COG0425@2|Bacteria,COG1765@2|Bacteria,1U9IG@1239|Firmicutes,4IJP4@91061|Bacilli,1ZCSK@1386|Bacillus	91061|Bacilli	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	OsmC,TusA
CMS3_k127_1801199_2	243274.THEMA_07380	1.374e-14	84.0	COG0500@1|root,COG2226@2|Bacteria,2GD3D@200918|Thermotogae	200918|Thermotogae	H	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS3_k127_1801199_0	379066.GAU_1743	8.438e-85	308.0	COG0534@1|root,COG0534@2|Bacteria,1ZUAU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MatE	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
CMS3_k127_1801199_1	1242864.D187_004430	2.534e-20	103.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2X5YN@28221|Deltaproteobacteria,2YUEJ@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12
CMS3_k127_1802491_1	886293.Sinac_6493	1.201e-29	125.0	COG0501@1|root,COG0501@2|Bacteria,2IYND@203682|Planctomycetes	203682|Planctomycetes	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CMS3_k127_1802491_0	113395.AXAI01000008_gene1087	6.616e-97	331.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2TS3N@28211|Alphaproteobacteria,3K3N4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CMS3_k127_1802694_0	1123508.JH636448_gene7676	7.944e-229	736.0	COG3794@1|root,COG3794@2|Bacteria,2J4VH@203682|Planctomycetes	203682|Planctomycetes	C	G8	-	-	-	-	-	-	-	-	-	-	-	-	G8
CMS3_k127_1802694_1	1123508.JH636440_gene2323	0.0004191	52.0	COG0515@1|root,COG0515@2|Bacteria,2IXRH@203682|Planctomycetes	203682|Planctomycetes	KLT	Serine threonine protein	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,LRR_6,Pkinase
CMS3_k127_1807048_0	290397.Adeh_0218	4.458e-96	318.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1149@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1149@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2Z2NY@29|Myxococcales	28221|Deltaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	poR	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
CMS3_k127_1807048_1	857087.Metme_1574	3.997e-79	278.0	COG1752@1|root,COG1752@2|Bacteria,1QJJS@1224|Proteobacteria,1THK7@1236|Gammaproteobacteria,1XENQ@135618|Methylococcales	135618|Methylococcales	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
CMS3_k127_1809519_1	521674.Plim_0695	3.335e-90	312.0	COG1508@1|root,COG1508@2|Bacteria,2IXGU@203682|Planctomycetes	203682|Planctomycetes	K	rna polymerase sigma-54 factor	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
CMS3_k127_1809519_3	1123368.AUIS01000020_gene1072	1.341e-41	159.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,2NCAC@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
CMS3_k127_1809519_2	1245475.ANAE01000002_gene127	1.09e-70	252.0	COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,4EIDE@85012|Streptosporangiales	201174|Actinobacteria	S	Possible lysine decarboxylase	fmt2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS3_k127_1809519_0	518766.Rmar_0074	9.462e-120	414.0	COG2866@1|root,COG2866@2|Bacteria,4NEJA@976|Bacteroidetes,1FIRV@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Secreted protein containing N-terminal Zinc-dependent carboxypeptidase related domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Peptidase_M14
CMS3_k127_1819306_1	1453500.AT05_10490	1.771e-33	140.0	COG0691@1|root,COG0691@2|Bacteria,4NNJU@976|Bacteroidetes,1I191@117743|Flavobacteriia	976|Bacteroidetes	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
CMS3_k127_1819306_0	1120948.KB903217_gene1241	5.069e-100	340.0	COG0042@1|root,COG0042@2|Bacteria,2GJ8I@201174|Actinobacteria,4DZKY@85010|Pseudonocardiales	201174|Actinobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090	-	-	-	-	-	-	-	-	-	-	Dus
CMS3_k127_1824549_0	1144275.COCOR_01630	3.737e-50	180.0	COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,42QUU@68525|delta/epsilon subdivisions,2WKRY@28221|Deltaproteobacteria,2YUWB@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
CMS3_k127_1824549_2	1397527.Q670_11215	9.599e-11	75.0	2AC29@1|root,30T0M@2|Bacteria,1REH0@1224|Proteobacteria,1S5IR@1236|Gammaproteobacteria,1XM5I@135619|Oceanospirillales	135619|Oceanospirillales	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1570,DUF4124
CMS3_k127_1824549_1	930169.B5T_02447	1.234e-47	185.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1XPNY@135619|Oceanospirillales	135619|Oceanospirillales	E	COG2303 Choline dehydrogenase and related flavoproteins	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
CMS3_k127_1839338_0	509191.AEDB02000109_gene5006	5.313e-07	61.0	COG4972@1|root,COG4972@2|Bacteria,1V3TN@1239|Firmicutes,24ASH@186801|Clostridia,3WHWV@541000|Ruminococcaceae	186801|Clostridia	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
CMS3_k127_1841717_0	391625.PPSIR1_34168	1.308e-139	451.0	COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,42MY0@68525|delta/epsilon subdivisions,2WM7X@28221|Deltaproteobacteria,2YUEI@29|Myxococcales	28221|Deltaproteobacteria	C	Isocitrate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
CMS3_k127_1841717_1	1340493.JNIF01000003_gene2039	6.653e-27	117.0	2E9F7@1|root,333NI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_187446_1	243090.RB10993	7.086e-07	54.0	COG1595@1|root,COG1595@2|Bacteria,2IZJK@203682|Planctomycetes	203682|Planctomycetes	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r4_2
CMS3_k127_187446_0	215803.DB30_6480	5.812e-72	274.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,42P8D@68525|delta/epsilon subdivisions,2WMH1@28221|Deltaproteobacteria,2YWWP@29|Myxococcales	28221|Deltaproteobacteria	KLT	COG0515 Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase,Pkinase_Tyr,WD40
CMS3_k127_1887051_2	1297742.A176_04476	3.73e-07	63.0	COG4932@1|root,COG4932@2|Bacteria,1NXIX@1224|Proteobacteria,430KM@68525|delta/epsilon subdivisions,2WVSB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_1887051_0	313628.LNTAR_22404	5.093e-156	506.0	COG3119@1|root,COG3119@2|Bacteria	313628.LNTAR_22404|-	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1887051_1	886293.Sinac_3984	1.529e-88	302.0	COG2373@1|root,COG2373@2|Bacteria,2IYJD@203682|Planctomycetes	203682|Planctomycetes	S	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
CMS3_k127_1902267_2	1158318.ATXC01000001_gene226	3.026e-07	51.0	COG2171@1|root,COG2171@2|Bacteria,2G3KV@200783|Aquificae	200783|Aquificae	E	Belongs to the transferase hexapeptide repeat family	-	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
CMS3_k127_1902267_0	1158318.ATXC01000001_gene319	1.055e-86	300.0	COG0624@1|root,COG0624@2|Bacteria,2G4GT@200783|Aquificae	200783|Aquificae	E	Peptidase dimerisation domain	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS3_k127_1902267_3	1423734.JCM14202_3531	0.0003264	50.0	COG1396@1|root,COG1396@2|Bacteria,1UUXA@1239|Firmicutes,4IFHI@91061|Bacilli,3F6H3@33958|Lactobacillaceae	91061|Bacilli	K	Bacteriophage CI repressor helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS3_k127_1902267_1	1278073.MYSTI_06568	1.798e-72	262.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,430H1@68525|delta/epsilon subdivisions,2WVZX@28221|Deltaproteobacteria,2YUWZ@29|Myxococcales	28221|Deltaproteobacteria	L	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,NUDIX
CMS3_k127_190233_5	502025.Hoch_4583	9.698e-48	185.0	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,42PAW@68525|delta/epsilon subdivisions,2WJV9@28221|Deltaproteobacteria,2Z31F@29|Myxococcales	28221|Deltaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	-	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
CMS3_k127_190233_3	443144.GM21_0222	1.314e-73	257.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
CMS3_k127_190233_0	1499967.BAYZ01000076_gene823	2.945e-157	505.0	COG2942@1|root,COG2942@2|Bacteria	2|Bacteria	G	2-epimerase	nanE	-	5.1.3.11,5.1.3.8	ko:K01787,ko:K16213	ko00520,map00520	-	R01207,R01445,R10810	RC00289,RC00290	ko00000,ko00001,ko01000	-	-	-	GlcNAc_2-epim
CMS3_k127_190233_6	344747.PM8797T_00177	8.419e-36	149.0	2ESRG@1|root,33K9V@2|Bacteria,2J33K@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_190233_1	926569.ANT_16550	4.085e-125	414.0	COG0451@1|root,COG0451@2|Bacteria,2G8B1@200795|Chloroflexi	200795|Chloroflexi	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS3_k127_190233_2	324602.Caur_0419	4.937e-107	372.0	COG1239@1|root,COG1239@2|Bacteria,2G5WJ@200795|Chloroflexi,37701@32061|Chloroflexia	32061|Chloroflexia	H	introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Mg_chelatase
CMS3_k127_190233_4	867845.KI911784_gene300	5.074e-60	228.0	COG1239@1|root,COG1240@1|root,COG1239@2|Bacteria,COG1240@2|Bacteria,2G5WJ@200795|Chloroflexi,376XX@32061|Chloroflexia	32061|Chloroflexia	H	introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX	-	-	6.6.1.1	ko:K03404	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,VWA_2
CMS3_k127_190233_7	1169144.KB910939_gene2850	3.996e-16	88.0	COG0454@1|root,COG0456@2|Bacteria,1V2UB@1239|Firmicutes,4HG0K@91061|Bacilli,1ZFBM@1386|Bacillus	91061|Bacilli	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_1904016_2	1500301.JQMF01000004_gene3665	0.0002795	52.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,2TTM8@28211|Alphaproteobacteria,4B7YE@82115|Rhizobiaceae	28211|Alphaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
CMS3_k127_1904016_1	204669.Acid345_1602	0.0002219	53.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS3_k127_1904016_0	240016.ABIZ01000001_gene875	2.788e-19	90.0	COG1520@1|root,COG1520@2|Bacteria,46UCM@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_1919945_4	926550.CLDAP_11790	7.534e-15	83.0	COG2244@1|root,COG4485@1|root,COG2244@2|Bacteria,COG4485@2|Bacteria,2G6CM@200795|Chloroflexi	200795|Chloroflexi	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
CMS3_k127_1919945_1	1121403.AUCV01000006_gene401	6.663e-84	293.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MN5K@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_1919945_5	1202768.JROF01000015_gene1059	5.687e-13	82.0	arCOG00567@1|root,arCOG00567@2157|Archaea,2XVU1@28890|Euryarchaeota,23UZV@183963|Halobacteria	183963|Halobacteria	M	glycosyl transferase family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_1919945_3	243231.GSU3007	4.351e-27	119.0	COG0406@1|root,COG0406@2|Bacteria,1RHAT@1224|Proteobacteria,42UAI@68525|delta/epsilon subdivisions,2WPQ6@28221|Deltaproteobacteria,43W0R@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Phosphoglycerate mutase family	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
CMS3_k127_1919945_6	1304874.JAFY01000007_gene2403	3.664e-05	51.0	COG0858@1|root,COG0858@2|Bacteria,3TBJ4@508458|Synergistetes	508458|Synergistetes	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
CMS3_k127_1919945_0	511051.CSE_05010	4.48e-254	804.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N,XFP,XFP_N
CMS3_k127_1919945_2	344747.PM8797T_15426	3.811e-53	195.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,2IXFD@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg
CMS3_k127_1920466_1	1142394.PSMK_22050	1.37e-27	121.0	28SBZ@1|root,2ZENV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1920466_0	1340493.JNIF01000003_gene4071	5.128e-133	437.0	COG0520@1|root,COG0520@2|Bacteria,3Y4TH@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_1920466_2	13035.Dacsa_2281	8.102e-24	117.0	COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,1G04D@1117|Cyanobacteria	1117|Cyanobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,PPC,Peptidase_S8
CMS3_k127_1920471_1	237368.SCABRO_02658	8.793e-140	457.0	COG0013@1|root,COG0013@2|Bacteria,2IX30@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
CMS3_k127_1920471_0	1142394.PSMK_01740	1.967e-142	461.0	COG0468@1|root,COG0468@2|Bacteria,2IX4U@203682|Planctomycetes	203682|Planctomycetes	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
CMS3_k127_1920471_3	292459.STH1664	3.433e-29	124.0	COG1514@1|root,COG1514@2|Bacteria,1VEU2@1239|Firmicutes,24MTR@186801|Clostridia	186801|Clostridia	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
CMS3_k127_1920471_2	314230.DSM3645_10162	1.82e-107	361.0	COG0524@1|root,COG0524@2|Bacteria,2IXGC@203682|Planctomycetes	203682|Planctomycetes	H	PFAM PfkB	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CMS3_k127_1920471_4	457398.HMPREF0326_01717	1.3e-23	113.0	COG0535@1|root,COG0535@2|Bacteria,1NJZV@1224|Proteobacteria,43CY9@68525|delta/epsilon subdivisions,2X625@28221|Deltaproteobacteria,2MGXE@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS3_k127_192963_0	945713.IALB_2321	1.154e-105	371.0	COG0308@1|root,COG0308@2|Bacteria	2|Bacteria	E	peptide catabolic process	pepN1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
CMS3_k127_1933114_3	379066.GAU_0985	7.464e-06	59.0	COG1413@1|root,COG4219@1|root,COG1413@2|Bacteria,COG4219@2|Bacteria,1ZUUA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,Peptidase_M56
CMS3_k127_1933114_1	345341.KUTG_07707	5.563e-118	399.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4E076@85010|Pseudonocardiales	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
CMS3_k127_1933114_2	1540257.JQMW01000011_gene1869	6.326e-87	302.0	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,36GS7@31979|Clostridiaceae	186801|Clostridia	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA2	-	1.17.1.11,1.17.1.9	ko:K00123,ko:K22341	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
CMS3_k127_1933114_0	207559.Dde_0473	5.437e-164	532.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2M8TZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
CMS3_k127_1933197_3	314345.SPV1_13042	1.453e-52	194.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria	1224|Proteobacteria	T	Carbon starvation protein	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
CMS3_k127_1933197_0	1379698.RBG1_1C00001G1671	2.003e-286	924.0	COG1228@1|root,COG1228@2|Bacteria,2NPD9@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
CMS3_k127_1933197_1	1183438.GKIL_2152	3.249e-116	398.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_1933197_2	643562.Daes_0169	6.853e-71	257.0	COG1073@1|root,COG1073@2|Bacteria,1MY4C@1224|Proteobacteria,42TB9@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Hydrolase_4
CMS3_k127_1935491_4	717785.HYPMC_4095	5.265e-06	57.0	COG3861@1|root,COG3861@2|Bacteria,1N0RC@1224|Proteobacteria,2TXMB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM PRC-barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PRC
CMS3_k127_1935491_3	234267.Acid_5135	4.397e-30	131.0	COG1595@1|root,COG1595@2|Bacteria,3Y7Z3@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1935491_1	1485544.JQKP01000020_gene61	1.273e-41	173.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VKYE@28216|Betaproteobacteria,44W7M@713636|Nitrosomonadales	28216|Betaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
CMS3_k127_1935491_2	330214.NIDE3051	8.498e-34	138.0	COG0745@1|root,COG0745@2|Bacteria	330214.NIDE3051|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1935491_0	330214.NIDE3050	1.421e-74	260.0	COG2202@1|root,COG3829@1|root,COG4251@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
CMS3_k127_1935851_6	637390.AFOH01000005_gene1012	0.0002445	46.0	COG1959@1|root,COG1959@2|Bacteria,1RE3F@1224|Proteobacteria,1TDGB@1236|Gammaproteobacteria,2NCVI@225057|Acidithiobacillales	225057|Acidithiobacillales	K	TIGRFAM Transcriptional regulator, Rrf2	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS3_k127_1935851_0	869210.Marky_1642	2.796e-183	585.0	COG3033@1|root,COG3033@2|Bacteria,1WM62@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
CMS3_k127_1935851_4	634497.HAH_1364	1.917e-31	136.0	COG0589@1|root,arCOG00449@2157|Archaea,2XU1E@28890|Euryarchaeota,23TYX@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_1935851_5	1121918.ARWE01000001_gene2311	1.169e-14	80.0	COG3448@1|root,COG3448@2|Bacteria,1QXNX@1224|Proteobacteria,43C4S@68525|delta/epsilon subdivisions,2X7F6@28221|Deltaproteobacteria,43UYW@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS3_k127_1935851_3	543728.Vapar_2851	1.25e-53	192.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,2WBQC@28216|Betaproteobacteria,4AI59@80864|Comamonadaceae	28216|Betaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CMS3_k127_1935851_1	700598.Niako_2474	9.505e-66	237.0	COG1397@1|root,COG1397@2|Bacteria,4NIZ9@976|Bacteroidetes	976|Bacteroidetes	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
CMS3_k127_1935851_2	861299.J421_6105	3.412e-65	244.0	COG0308@1|root,COG0739@1|root,COG0308@2|Bacteria,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K08642,ko:K21472	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Cu_amine_oxidN1,Peptidase_M1,Peptidase_M23
CMS3_k127_1937277_0	344747.PM8797T_20983	2.087e-145	478.0	COG1520@1|root,COG1520@2|Bacteria,2J213@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_1937277_1	190650.CC_0985	1.737e-28	122.0	COG2866@1|root,COG2866@2|Bacteria,1N9W9@1224|Proteobacteria,2U2SA@28211|Alphaproteobacteria,2KHH2@204458|Caulobacterales	204458|Caulobacterales	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS3_k127_1938081_1	262724.TT_C0044	4.94e-83	289.0	COG0232@1|root,COG0232@2|Bacteria,1WI39@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Belongs to the dGTPase family. Type 2 subfamily	-	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
CMS3_k127_1938081_0	1242864.D187_006463	1.624e-124	406.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WJUZ@28221|Deltaproteobacteria,2YUJY@29|Myxococcales	28221|Deltaproteobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_1938081_2	1210884.HG799463_gene10285	5.379e-67	239.0	COG1721@1|root,COG1721@2|Bacteria,2IXT7@203682|Planctomycetes	203682|Planctomycetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_1938081_8	502025.Hoch_0521	7.288e-08	65.0	2DQN8@1|root,337RD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1938081_4	36874.HQ34_04540	2.906e-49	188.0	COG2304@1|root,COG2304@2|Bacteria,4NDUC@976|Bacteroidetes,2FNXM@200643|Bacteroidia,22XC0@171551|Porphyromonadaceae	976|Bacteroidetes	S	Von Willebrand factor type A domain	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
CMS3_k127_1938081_3	1242864.D187_006459	1.747e-50	194.0	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,42M45@68525|delta/epsilon subdivisions,2WM19@28221|Deltaproteobacteria,2Z15V@29|Myxococcales	28221|Deltaproteobacteria	S	von Willebrand factor (vWF) type A domain	batB	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,TPR_1,TPR_16,TPR_2,VWA,VWA_2
CMS3_k127_1938081_6	1197477.IA57_05950	2.085e-22	113.0	COG0457@1|root,COG0457@2|Bacteria,4NERG@976|Bacteroidetes,1HYP9@117743|Flavobacteriia	976|Bacteroidetes	S	Oxygen tolerance	batD	-	-	-	-	-	-	-	-	-	-	-	BatD,TPR_2
CMS3_k127_1938081_7	1121875.KB907547_gene3317	6.555e-09	66.0	COG0457@1|root,COG0457@2|Bacteria,4NF5V@976|Bacteroidetes,1HYKU@117743|Flavobacteriia	976|Bacteroidetes	T	tetratricopeptide repeat	batE	-	-	-	-	-	-	-	-	-	-	-	SH3_3,SH3_4,TPR_1,TPR_11,TPR_16,TPR_2
CMS3_k127_1938081_5	1042156.CXIVA_05200	6.877e-43	164.0	COG0284@1|root,COG0284@2|Bacteria,1TQ7P@1239|Firmicutes,247SZ@186801|Clostridia,36E3E@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17585	OMPdecase
CMS3_k127_1942254_1	316056.RPC_0535	2.456e-08	59.0	COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2UF6U@28211|Alphaproteobacteria,3K0BM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Belongs to the BolA IbaG family	bolA	GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:0097428,GO:0106035,GO:1901564	-	ko:K05527,ko:K22066	-	-	-	-	ko00000,ko03000,ko03029	-	-	-	BolA
CMS3_k127_1942254_0	1254432.SCE1572_25750	3.881e-209	659.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,42MMB@68525|delta/epsilon subdivisions,2WJEI@28221|Deltaproteobacteria,2Z2X3@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
CMS3_k127_1942254_2	1232410.KI421412_gene100	3.848e-06	58.0	COG1286@1|root,COG1286@2|Bacteria,1NIBK@1224|Proteobacteria,42UFS@68525|delta/epsilon subdivisions,2WQIK@28221|Deltaproteobacteria,43SMV@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
CMS3_k127_194575_0	309807.SRU_1933	3.993e-106	358.0	COG3191@1|root,COG3191@2|Bacteria,4NGDT@976|Bacteroidetes,1FJRD@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
CMS3_k127_194575_1	1396141.BATP01000003_gene5275	7.647e-22	106.0	2FHAY@1|root,34957@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1949366_5	903818.KI912268_gene1754	4.098e-59	209.0	COG1898@1|root,COG1898@2|Bacteria	2|Bacteria	M	dTDP-4-dehydrorhamnose 3,5-epimerase activity	rfbC	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
CMS3_k127_1949366_6	459495.SPLC1_S501150	2.001e-39	151.0	COG1586@1|root,COG1586@2|Bacteria,1G5QZ@1117|Cyanobacteria,1HBEA@1150|Oscillatoriales	1117|Cyanobacteria	H	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
CMS3_k127_1949366_0	1380394.JADL01000017_gene521	1.64e-152	500.0	COG1902@1|root,COG1902@2|Bacteria,1R4A8@1224|Proteobacteria,2UQVT@28211|Alphaproteobacteria,2JW8F@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
CMS3_k127_1949366_4	1068980.ARVW01000001_gene861	3.026e-76	263.0	COG1028@1|root,COG1028@2|Bacteria,2H0SM@201174|Actinobacteria,4E07R@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
CMS3_k127_1949366_2	208444.JNYY01000009_gene3600	1.473e-109	371.0	COG1024@1|root,COG1024@2|Bacteria,2GJ7Z@201174|Actinobacteria,4E2EI@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	echA5	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS3_k127_1949366_7	479433.Caci_5521	2.287e-38	148.0	COG0251@1|root,COG0251@2|Bacteria,2IHXH@201174|Actinobacteria	201174|Actinobacteria	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
CMS3_k127_1949366_10	1232410.KI421416_gene2662	0.0007364	48.0	2EB1N@1|root,3352G@2|Bacteria,1NDEY@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1949366_8	452637.Oter_1491	6.396e-29	131.0	COG3014@1|root,COG3014@2|Bacteria	2|Bacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_1949366_9	264198.Reut_B4205	7.84e-17	90.0	COG3417@1|root,COG3417@2|Bacteria,1RAWS@1224|Proteobacteria	1224|Proteobacteria	M	Peptidoglycan-synthase activator LpoB	-	-	-	ko:K07337	-	-	-	-	ko00000	-	-	-	LpoB
CMS3_k127_1949366_3	309799.DICTH_0722	1.793e-107	363.0	COG2805@1|root,COG2805@2|Bacteria	2|Bacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS3_k127_1949366_1	1445613.JALM01000016_gene6186	9.348e-129	425.0	COG1960@1|root,COG1960@2|Bacteria,2GK1M@201174|Actinobacteria,4DZ7D@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_195026_0	177437.HRM2_45530	7.364e-72	272.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,42SPI@68525|delta/epsilon subdivisions,2WQM8@28221|Deltaproteobacteria,2MKXA@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Subtilase family	-	-	3.4.21.62	ko:K01342,ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I9,PA,Peptidase_S8
CMS3_k127_195140_0	1144275.COCOR_02106	5.107e-10	72.0	COG0793@1|root,COG4932@1|root,COG0793@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	espK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K13735,ko:K18491,ko:K20276	ko02024,ko04550,ko05100,map02024,map04550,map05100	-	-	-	ko00000,ko00001,ko03000	-	-	-	CarboxypepD_reg,PDZ_2
CMS3_k127_1955909_1	344747.PM8797T_24906	1.468e-27	129.0	COG4219@1|root,COG4219@2|Bacteria,2IZRJ@203682|Planctomycetes	203682|Planctomycetes	KT	Antirepressor regulating drug resistance	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
CMS3_k127_1955909_5	565045.NOR51B_1786	3.483e-05	55.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
CMS3_k127_1955909_2	502025.Hoch_1914	9.297e-15	77.0	297WK@1|root,2ZV33@2|Bacteria,1P83J@1224|Proteobacteria,432YB@68525|delta/epsilon subdivisions,2WYBG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1955909_4	76114.ebB134	7.646e-12	75.0	2E4RD@1|root,331HW@2|Bacteria,1QTR4@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1955909_3	76114.ebB134	4.792e-13	79.0	2E4RD@1|root,331HW@2|Bacteria,1QTR4@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1955909_0	471852.Tcur_2191	2.05e-181	622.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4EH1A@85012|Streptosporangiales	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS3_k127_1962495_1	1347368.HG964409_gene7252	1.999e-30	131.0	COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,4HFNQ@91061|Bacilli,1ZAVP@1386|Bacillus	91061|Bacilli	C	glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS3_k127_1962495_0	686340.Metal_2952	2.173e-139	462.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,1XED8@135618|Methylococcales	135618|Methylococcales	C	C-terminal domain of alpha-glycerophosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,DAO_C
CMS3_k127_1969075_3	1288494.EBAPG3_26360	3.189e-07	63.0	COG0308@1|root,COG0308@2|Bacteria,1PVVK@1224|Proteobacteria,2VIU3@28216|Betaproteobacteria,3722N@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
CMS3_k127_1969075_0	756272.Plabr_2883	7.1e-89	309.0	COG0515@1|root,COG0515@2|Bacteria,2J2D5@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_1969075_1	595460.RRSWK_04882	4.557e-54	205.0	COG0631@1|root,COG0631@2|Bacteria	2|Bacteria	T	protein serine/threonine phosphatase activity	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
CMS3_k127_1969075_2	498761.HM1_0326	9.638e-41	154.0	COG0662@1|root,COG0662@2|Bacteria,1V7K2@1239|Firmicutes,24JIQ@186801|Clostridia	186801|Clostridia	G	PFAM Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_1969075_4	1121877.JQKF01000033_gene2006	0.0001	52.0	COG3055@1|root,COG3055@2|Bacteria,2HC50@201174|Actinobacteria	201174|Actinobacteria	S	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4
CMS3_k127_1971008_0	357808.RoseRS_0010	2.273e-94	338.0	COG0823@1|root,COG0823@2|Bacteria,2G8T5@200795|Chloroflexi,376FH@32061|Chloroflexia	32061|Chloroflexia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
CMS3_k127_1971008_1	745718.JADT01000001_gene1895	1.006e-26	112.0	COG2203@1|root,COG2204@1|root,COG3604@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG3604@2|Bacteria,4NE89@976|Bacteroidetes,1I08N@117743|Flavobacteriia	976|Bacteroidetes	T	Fis family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HTH_8,PAS_3,PAS_9,Response_reg,Sigma54_activat
CMS3_k127_1975786_0	1137281.D778_02007	1.213e-59	227.0	COG3278@1|root,COG3278@2|Bacteria,4NIGA@976|Bacteroidetes,1HZJ7@117743|Flavobacteriia	976|Bacteroidetes	O	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
CMS3_k127_1975786_3	1268622.AVS7_03872	0.0001424	52.0	COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,2VNWY@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C
CMS3_k127_1975786_1	1121896.JMLU01000024_gene2519	1.324e-18	95.0	COG2010@1|root,COG2010@2|Bacteria,4PGSP@976|Bacteroidetes,1ID8M@117743|Flavobacteriia,2NXQS@237|Flavobacterium	976|Bacteroidetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
CMS3_k127_1975786_2	485918.Cpin_6429	6.319e-11	66.0	COG0526@1|root,COG0526@2|Bacteria,4P20Z@976|Bacteroidetes,1IVMR@117747|Sphingobacteriia	976|Bacteroidetes	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF4369
CMS3_k127_1976047_0	1284352.AOIG01000013_gene3550	1.507e-36	159.0	COG0457@1|root,COG3210@1|root,COG5492@1|root,COG0457@2|Bacteria,COG3210@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
CMS3_k127_1986140_1	7918.ENSLOCP00000020208	5.039e-23	115.0	COG0457@1|root,KOG1124@2759|Eukaryota,38CY4@33154|Opisthokonta,3BAFG@33208|Metazoa,3CV6Z@33213|Bilateria,480W8@7711|Chordata,4967I@7742|Vertebrata,49V00@7898|Actinopterygii	33208|Metazoa	S	Transmembrane and tetratricopeptide repeat containing 3	TMTC3	GO:0001763,GO:0002009,GO:0003401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006950,GO:0007275,GO:0008150,GO:0009653,GO:0009791,GO:0009887,GO:0009888,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010468,GO:0010604,GO:0012505,GO:0019222,GO:0030154,GO:0030162,GO:0030323,GO:0030324,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0033554,GO:0034976,GO:0035239,GO:0035295,GO:0040007,GO:0042176,GO:0042692,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0045732,GO:0045862,GO:0048286,GO:0048468,GO:0048513,GO:0048518,GO:0048522,GO:0048589,GO:0048729,GO:0048731,GO:0048747,GO:0048754,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051146,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051716,GO:0055001,GO:0055002,GO:0060255,GO:0060425,GO:0060429,GO:0060441,GO:0060447,GO:0060541,GO:0060560,GO:0060562,GO:0060602,GO:0061061,GO:0061136,GO:0061138,GO:0065007,GO:0080090,GO:1901800,GO:1903050,GO:1903052,GO:1903362,GO:1903364	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
CMS3_k127_1986140_0	521674.Plim_2636	8.331e-133	443.0	COG3250@1|root,COG3250@2|Bacteria,2J54D@203682|Planctomycetes	203682|Planctomycetes	G	Pfam:DUF303	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	SASA
CMS3_k127_198955_0	868131.MSWAN_2287	8.786e-44	168.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,23NMT@183925|Methanobacteria	183925|Methanobacteria	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
CMS3_k127_198955_1	290397.Adeh_0014	4.194e-38	154.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WNPT@28221|Deltaproteobacteria,2YVDG@29|Myxococcales	28221|Deltaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CMS3_k127_198955_2	944479.JQLX01000010_gene501	3.62e-06	54.0	COG0745@1|root,COG2200@1|root,COG0745@2|Bacteria,COG2200@2|Bacteria,1NQKX@1224|Proteobacteria,43AWS@68525|delta/epsilon subdivisions,2WUX5@28221|Deltaproteobacteria,2M6Z0@213113|Desulfurellales	28221|Deltaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,PAS_3,Response_reg
CMS3_k127_1996537_1	1123242.JH636435_gene1545	1.479e-54	207.0	COG2755@1|root,COG2755@2|Bacteria,2IZAF@203682|Planctomycetes	203682|Planctomycetes	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS3_k127_1996537_0	1123278.KB893433_gene658	1.108e-112	379.0	COG2942@1|root,COG2942@2|Bacteria,4NHTQ@976|Bacteroidetes,47KVQ@768503|Cytophagia	976|Bacteroidetes	G	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)	-	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
CMS3_k127_1996537_2	445972.ANACOL_03797	1.749e-07	55.0	COG2870@1|root,COG2870@2|Bacteria,1TSMF@1239|Firmicutes,24FJA@186801|Clostridia	186801|Clostridia	H	ADP-heptose synthase, bifunctional sugar kinase adenylyltransferase	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
CMS3_k127_199667_2	1408422.JHYF01000009_gene1966	1.239e-31	128.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,36DCT@31979|Clostridiaceae	186801|Clostridia	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
CMS3_k127_199667_1	596329.HMPREF0631_1896	1.845e-54	201.0	COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,25RA2@186804|Peptostreptococcaceae	186801|Clostridia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
CMS3_k127_199667_0	344747.PM8797T_14691	2.636e-69	251.0	COG1191@1|root,COG1191@2|Bacteria,2IX9S@203682|Planctomycetes	203682|Planctomycetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS3_k127_199667_3	1382359.JIAL01000001_gene2158	7.738e-28	123.0	COG0745@1|root,COG0745@2|Bacteria,3Y55U@57723|Acidobacteria,2JJQC@204432|Acidobacteriia	204432|Acidobacteriia	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
CMS3_k127_199667_4	177439.DP2650	8.606e-08	62.0	COG1406@1|root,COG1406@2|Bacteria,1N38Q@1224|Proteobacteria,42UIA@68525|delta/epsilon subdivisions,2WQV5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	Chemotaxis phosphatase CheX	cheX64H	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
CMS3_k127_1997114_1	314271.RB2654_06439	2.674e-44	174.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2
CMS3_k127_1997114_0	502025.Hoch_5169	6.205e-103	349.0	COG0258@1|root,COG0258@2|Bacteria,1QV40@1224|Proteobacteria,43BZM@68525|delta/epsilon subdivisions,2X7AE@28221|Deltaproteobacteria,2YUE3@29|Myxococcales	28221|Deltaproteobacteria	L	Helix-hairpin-helix class 2 (Pol1 family) motifs	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
CMS3_k127_1998663_0	314287.GB2207_04024	4.191e-184	586.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,1RQAM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	amidohydrolase	hipO	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_2004380_3	378806.STAUR_0277	1.495e-82	286.0	COG2367@1|root,COG2367@2|Bacteria,1Q2UC@1224|Proteobacteria,438GK@68525|delta/epsilon subdivisions,2X3RE@28221|Deltaproteobacteria,2YWXF@29|Myxococcales	28221|Deltaproteobacteria	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
CMS3_k127_2004380_1	946362.XP_004993723.1	8.872e-101	358.0	COG0139@1|root,COG0141@1|root,KOG2697@2759|Eukaryota,KOG4311@2759|Eukaryota,38HWK@33154|Opisthokonta	33154|Opisthokonta	E	Histidine biosynthesis trifunctional protein	-	-	1.1.1.23,3.5.4.19,3.6.1.31	ko:K14152	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012,R04035,R04037	RC00002,RC00099,RC00242,RC00463,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh,PRA-CH,PRA-PH
CMS3_k127_2004380_0	1089551.KE386572_gene3677	6.923e-132	447.0	COG0106@1|root,COG0139@1|root,COG0106@2|Bacteria,COG0139@2|Bacteria,1MW6S@1224|Proteobacteria,2TRSG@28211|Alphaproteobacteria,4BQ2C@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CMS3_k127_2004380_2	1089551.KE386572_gene3676	8.116e-83	293.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2TQXD@28211|Alphaproteobacteria,4BPZG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CMS3_k127_2004380_4	5334.XP_003035005.1	5.044e-69	240.0	COG0131@1|root,KOG3143@2759|Eukaryota,38GFB@33154|Opisthokonta,3NV4T@4751|Fungi,3V02Q@5204|Basidiomycota,224MY@155619|Agaricomycetes,3W331@5338|Agaricales	4751|Fungi	E	Imidazoleglycerol-phosphate dehydratase	HIS3	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
CMS3_k127_2004380_5	204669.Acid345_3684	1.114e-37	154.0	COG0079@1|root,COG0079@2|Bacteria,3Y3M6@57723|Acidobacteria,2JIS3@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_2007103_4	497965.Cyan7822_4280	1.265e-07	64.0	COG1413@1|root,COG1413@2|Bacteria,1GDQE@1117|Cyanobacteria	1117|Cyanobacteria	C	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT,HEAT_2,HEAT_PBS
CMS3_k127_2007103_0	1408254.T458_08895	7.647e-27	115.0	COG0346@1|root,COG0346@2|Bacteria,1VUGP@1239|Firmicutes,4HVRI@91061|Bacilli,273G7@186822|Paenibacillaceae	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_2007103_3	485914.Hmuk_0132	4.255e-10	71.0	arCOG08111@1|root,arCOG08111@2157|Archaea,2XYM7@28890|Euryarchaeota,23WH7@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF3592)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3592
CMS3_k127_2007103_2	693746.OBV_10250	3.361e-16	81.0	COG3326@1|root,COG3326@2|Bacteria,1UFGP@1239|Firmicutes,25KRA@186801|Clostridia,2N7JI@216572|Oscillospiraceae	186801|Clostridia	S	Protein of unknown function (DUF1294)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1294
CMS3_k127_2007103_1	1121897.AUGO01000011_gene3136	1.072e-20	106.0	2EJY0@1|root,33DNN@2|Bacteria,4NZ7W@976|Bacteroidetes,1IBBP@117743|Flavobacteriia,2NXSC@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2016260_0	880073.Calab_0437	4.122e-112	380.0	COG2204@1|root,COG2204@2|Bacteria,2NNPN@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	sasR	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_2016260_1	886293.Sinac_5466	6.288e-21	106.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42,Glyco_hydro_42M
CMS3_k127_2017722_1	344747.PM8797T_07137	6.291e-92	310.0	COG1680@1|root,COG3876@1|root,COG1680@2|Bacteria,COG3876@2|Bacteria,2IXF2@203682|Planctomycetes	203682|Planctomycetes	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343
CMS3_k127_2017722_0	234267.Acid_6976	2.118e-147	488.0	28JZQ@1|root,2Z9PN@2|Bacteria,3Y4UW@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2033102_3	448385.sce8271	2.957e-20	107.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,42NIZ@68525|delta/epsilon subdivisions,2WM5U@28221|Deltaproteobacteria,2Z315@29|Myxococcales	28221|Deltaproteobacteria	E	Domain of unknown function (DUF3488)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,DUF4129,Transglut_core
CMS3_k127_2033102_5	222534.KB893670_gene3864	2.955e-07	63.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4ERVY@85013|Frankiales	201174|Actinobacteria	J	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_2033102_0	357808.RoseRS_0587	1.959e-81	300.0	COG0714@1|root,COG0714@2|Bacteria,2G87C@200795|Chloroflexi,376E2@32061|Chloroflexia	32061|Chloroflexia	S	ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_2033102_2	1358423.N180_05965	5.536e-21	98.0	COG0861@1|root,COG0861@2|Bacteria,4NFFD@976|Bacteroidetes,1IQQC@117747|Sphingobacteriia	976|Bacteroidetes	P	Membrane protein TerC, possibly involved in tellurium resistance	-	-	-	-	-	-	-	-	-	-	-	-	TerC
CMS3_k127_2033102_1	504472.Slin_4183	4.988e-54	206.0	COG1577@1|root,COG1577@2|Bacteria,4NH6H@976|Bacteroidetes,47N8V@768503|Cytophagia	976|Bacteroidetes	I	GHMP kinases C terminal	-	-	2.7.1.43	ko:K16190	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014	R01476	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
CMS3_k127_2033102_4	1175629.AJTG01000006_gene497	6.241e-14	83.0	COG1208@1|root,COG1208@2|Bacteria,1V5SC@1239|Firmicutes,4HI1U@91061|Bacilli	91061|Bacilli	JM	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CMS3_k127_204514_0	1121033.AUCF01000001_gene2521	5.935e-56	209.0	COG0729@1|root,COG1752@1|root,COG0729@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TS79@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,Patatin
CMS3_k127_204514_1	717606.PaecuDRAFT_2665	3.478e-10	74.0	COG0793@1|root,COG4932@1|root,COG0793@2|Bacteria,COG4932@2|Bacteria,1UJQY@1239|Firmicutes,4ITDJ@91061|Bacilli,270X3@186822|Paenibacillaceae	91061|Bacilli	M	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_2050502_0	1254432.SCE1572_17685	1.009e-89	336.0	COG0515@1|root,COG2203@1|root,COG3829@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YI@28221|Deltaproteobacteria,2YTVN@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory protein, Fis family	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Pkinase,PocR,Sigma54_activat
CMS3_k127_2060582_1	99598.Cal7507_3395	3.404e-27	121.0	COG1520@1|root,COG1520@2|Bacteria,1GHEB@1117|Cyanobacteria,1HKIG@1161|Nostocales	1117|Cyanobacteria	C	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	PPC
CMS3_k127_2060582_3	1255043.TVNIR_2224	1.418e-05	55.0	2C0RW@1|root,2ZBA6@2|Bacteria,1RJAD@1224|Proteobacteria,1S0FF@1236|Gammaproteobacteria,1WWR0@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2060582_0	1379270.AUXF01000005_gene710	5.544e-99	333.0	COG0158@1|root,COG0158@2|Bacteria,1ZTAZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Fructose-1-6-bisphosphatase, N-terminal domain	fbp	-	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
CMS3_k127_2060582_2	1107311.Q767_04465	1.117e-18	90.0	COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,1HX7X@117743|Flavobacteriia,2NTJM@237|Flavobacterium	976|Bacteroidetes	S	peptidase, M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
CMS3_k127_2064790_0	1303518.CCALI_00495	6.469e-195	631.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771,ko:K08372	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
CMS3_k127_2074864_5	469383.Cwoe_0202	1.379e-92	320.0	COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,4CPQ8@84995|Rubrobacteria	84995|Rubrobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
CMS3_k127_2074864_1	756272.Plabr_0662	2.232e-223	699.0	COG4102@1|root,COG4102@2|Bacteria,2J28W@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_2074864_0	756272.Plabr_0661	1.949e-289	916.0	COG2010@1|root,COG2010@2|Bacteria,2J1RW@203682|Planctomycetes	203682|Planctomycetes	C	Protein of unknown function (DUF1549)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
CMS3_k127_2074864_4	530564.Psta_3646	1.214e-142	473.0	COG3119@1|root,COG3119@2|Bacteria,2IXPB@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
CMS3_k127_2074864_6	530564.Psta_2919	1.553e-18	100.0	COG5349@1|root,COG5349@2|Bacteria,2J1NF@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
CMS3_k127_2074864_3	471854.Dfer_2566	4.427e-143	475.0	2CD2X@1|root,2Z7RW@2|Bacteria,4NI6Q@976|Bacteroidetes,47M77@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2074864_7	313624.NSP_13800	6.402e-16	90.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1G705@1117|Cyanobacteria,1HP47@1161|Nostocales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2,RgpF
CMS3_k127_2074864_8	1121937.AUHJ01000004_gene1062	0.0002511	49.0	2E57Z@1|root,3300G@2|Bacteria,1NBSS@1224|Proteobacteria,1SEIN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2074864_2	344747.PM8797T_17407	4.264e-145	463.0	COG0673@1|root,COG0673@2|Bacteria,2IWTD@203682|Planctomycetes	203682|Planctomycetes	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_2077338_1	247490.KSU1_C0526	1.688e-54	210.0	COG0265@1|root,COG0265@2|Bacteria,2IXAW@203682|Planctomycetes	203682|Planctomycetes	O	typically periplasmic contain C-terminal PDZ domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_2077338_0	1519464.HY22_12075	0.0	1343.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
CMS3_k127_2084168_2	640081.Dsui_0653	3.394e-06	49.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,2KUS1@206389|Rhodocyclales	206389|Rhodocyclales	J	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
CMS3_k127_2084168_0	1125863.JAFN01000001_gene1869	5.993e-139	475.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
CMS3_k127_2084168_1	1267535.KB906767_gene1733	1.013e-127	413.0	COG0016@1|root,COG0016@2|Bacteria,3Y3NJ@57723|Acidobacteria,2JIN8@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
CMS3_k127_2094099_2	1288298.rosmuc_02772	5.414e-12	81.0	COG2931@1|root,COG5276@1|root,COG2931@2|Bacteria,COG5276@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,46P2B@74030|Roseovarius	28211|Alphaproteobacteria	MQ	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Collar,HemolysinCabind,Peptidase_M10_C
CMS3_k127_2094099_3	690850.Desaf_0428	3.161e-07	66.0	COG3266@1|root,COG3391@1|root,COG4870@1|root,COG3266@2|Bacteria,COG3391@2|Bacteria,COG4870@2|Bacteria,1NC9B@1224|Proteobacteria,42Z35@68525|delta/epsilon subdivisions,2WTVH@28221|Deltaproteobacteria,2MD34@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM Peptidase C1A, papain C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
CMS3_k127_2094099_0	1123508.JH636439_gene332	1.26e-24	123.0	COG2373@1|root,COG2931@1|root,COG3209@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,2J3BU@203682|Planctomycetes	203682|Planctomycetes	Q	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2094099_1	1209984.BN978_04074	1.021e-17	98.0	COG3209@1|root,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria,23EHB@1762|Mycobacteriaceae	201174|Actinobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
CMS3_k127_2094337_0	570967.JMLV01000002_gene1773	4.644e-110	384.0	COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,2TSIN@28211|Alphaproteobacteria,2JPY4@204441|Rhodospirillales	204441|Rhodospirillales	M	Mechanosensitive ion channel	-	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
CMS3_k127_2102111_0	153721.MYP_2760	5.178e-84	310.0	COG3146@1|root,COG3146@2|Bacteria,4NI7H@976|Bacteroidetes	976|Bacteroidetes	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6,FemAB_like
CMS3_k127_2102111_1	448385.sce3153	1.419e-22	102.0	COG0670@1|root,COG0670@2|Bacteria,1R7VN@1224|Proteobacteria,43DVQ@68525|delta/epsilon subdivisions,2WZ04@28221|Deltaproteobacteria,2Z11K@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the BI1 family	-	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
CMS3_k127_2102571_1	313628.LNTAR_01922	5.204e-29	117.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS3_k127_2102571_0	497964.CfE428DRAFT_2806	5.039e-74	256.0	COG1028@1|root,COG1028@2|Bacteria,46UZ4@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_2102571_2	1151126.AQYI01000006_gene2751	0.0005001	53.0	COG4932@1|root,COG4932@2|Bacteria,2HU92@201174|Actinobacteria,4FSW9@85023|Microbacteriaceae	201174|Actinobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_2116436_0	246197.MXAN_2471	9.989e-14	81.0	COG4235@1|root,COG4235@2|Bacteria,1QX9S@1224|Proteobacteria,43C2Y@68525|delta/epsilon subdivisions,2X7DK@28221|Deltaproteobacteria,2YWM2@29|Myxococcales	28221|Deltaproteobacteria	O	cytochrome complex assembly	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2116436_2	1380390.JIAT01000015_gene5755	4.398e-05	54.0	2B412@1|root,31WRB@2|Bacteria,2HY97@201174|Actinobacteria,4CQGQ@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2116436_1	471854.Dfer_5703	3.549e-10	73.0	COG1305@1|root,COG1305@2|Bacteria,4NF37@976|Bacteroidetes,47TZP@768503|Cytophagia	976|Bacteroidetes	E	Protein of unknown function (DUF2569)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2569,DUF3857,Transglut_core
CMS3_k127_212163_0	1267535.KB906767_gene2168	3.31e-216	704.0	COG1529@1|root,COG1529@2|Bacteria,3Y3J7@57723|Acidobacteria,2JMHB@204432|Acidobacteriia	204432|Acidobacteriia	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K00256	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS3_k127_212163_1	234267.Acid_7218	2.442e-58	211.0	COG2080@1|root,COG2080@2|Bacteria,3Y5EJ@57723|Acidobacteria	57723|Acidobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CMS3_k127_212163_2	1280949.HAD_05125	5.772e-25	109.0	COG0405@1|root,COG0405@2|Bacteria,1Q089@1224|Proteobacteria,2U8PM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CMS3_k127_2121885_0	448385.sce4028	1.608e-116	383.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,42QIH@68525|delta/epsilon subdivisions,2WIR8@28221|Deltaproteobacteria,2Z1HA@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	rbsC	-	-	ko:K02057,ko:K10440	ko02010,map02010	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
CMS3_k127_2121885_1	314230.DSM3645_06049	4.41e-104	347.0	COG1129@1|root,COG1129@2|Bacteria,2IWTU@203682|Planctomycetes	203682|Planctomycetes	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	rbsA	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
CMS3_k127_2133606_0	1313304.CALK_0297	1.575e-138	471.0	COG4581@1|root,COG4581@2|Bacteria	2|Bacteria	L	dead DEAH box helicase	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
CMS3_k127_2133606_3	484019.THA_1312	2.884e-38	151.0	COG0102@1|root,COG0102@2|Bacteria,2GD15@200918|Thermotogae	200918|Thermotogae	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
CMS3_k127_2133606_2	886293.Sinac_5143	6.716e-41	163.0	COG0103@1|root,COG0103@2|Bacteria,2J01J@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
CMS3_k127_2133606_1	1121439.dsat_2578	1.7e-80	276.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2M7WJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
CMS3_k127_2133606_4	1144275.COCOR_05401	3.232e-13	80.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42Q7A@68525|delta/epsilon subdivisions,2WM81@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF
CMS3_k127_2146282_5	62928.azo0278	5.744e-05	55.0	2EFNF@1|root,339EK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2146282_2	264732.Moth_1753	2.501e-39	158.0	COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,248DV@186801|Clostridia,42GJG@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
CMS3_k127_2146282_0	204669.Acid345_2614	5.504e-132	438.0	COG2256@1|root,COG2256@2|Bacteria,3Y3F7@57723|Acidobacteria,2JIAH@204432|Acidobacteriia	204432|Acidobacteriia	L	AAA ATPase	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
CMS3_k127_2146282_1	391625.PPSIR1_29518	9.196e-89	308.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,42S9C@68525|delta/epsilon subdivisions,2WM4G@28221|Deltaproteobacteria,2YU8Y@29|Myxococcales	28221|Deltaproteobacteria	Q	Dienelactone hydrolase family	dlhH2	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
CMS3_k127_2146282_3	1403819.BATR01000162_gene5452	1.808e-19	102.0	2E533@1|root,32ZW9@2|Bacteria,46X7Y@74201|Verrucomicrobia,2IUXW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2146282_4	1173024.KI912149_gene4953	3.805e-15	79.0	COG3153@1|root,COG3153@2|Bacteria,1G3A1@1117|Cyanobacteria,1JKMA@1189|Stigonemataceae	1117|Cyanobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
CMS3_k127_2146691_6	452652.KSE_50560	6.297e-10	71.0	COG1595@1|root,COG1595@2|Bacteria,2GJIZ@201174|Actinobacteria,2M2DF@2063|Kitasatospora	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_2146691_3	1123508.JH636439_gene716	4.379e-65	236.0	COG4974@1|root,COG4974@2|Bacteria,2IX6A@203682|Planctomycetes	203682|Planctomycetes	D	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS3_k127_2146691_1	1121422.AUMW01000022_gene1553	1.462e-85	301.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,26020@186807|Peptococcaceae	186801|Clostridia	EH	Anthranilate synthase component I	pabB	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind,GATase
CMS3_k127_2146691_5	136273.GY22_00985	1.309e-21	105.0	COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,1W83E@1268|Micrococcaceae	201174|Actinobacteria	EH	synthase component I	pabB	-	2.6.1.85,4.1.3.27,4.1.3.38	ko:K01657,ko:K01665,ko:K03342,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716,R05553	RC00010,RC01418,RC01843,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Anth_synt_I_N,Chorismate_bind,GATase
CMS3_k127_2146691_2	552398.HMPREF0866_00713	8.972e-66	236.0	COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,248DE@186801|Clostridia,3WINP@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iHN637.CLJU_RS05465	polyprenyl_synt
CMS3_k127_2146691_0	247490.KSU1_D0796	1.091e-174	570.0	COG1154@1|root,COG1154@2|Bacteria,2IYHC@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
CMS3_k127_2146691_4	247490.KSU1_D0795	4.265e-51	192.0	COG0061@1|root,COG0061@2|Bacteria,2IXD3@203682|Planctomycetes	203682|Planctomycetes	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
CMS3_k127_2149560_1	1122226.AUHX01000001_gene1026	7.295e-14	79.0	COG0223@1|root,COG0223@2|Bacteria,4NE8U@976|Bacteroidetes,1HX64@117743|Flavobacteriia	976|Bacteroidetes	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
CMS3_k127_2149560_0	240016.ABIZ01000001_gene4336	7.535e-52	198.0	COG0265@1|root,COG0750@1|root,COG0265@2|Bacteria,COG0750@2|Bacteria	2|Bacteria	M	metalloendopeptidase activity	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
CMS3_k127_2149560_2	521674.Plim_4016	6.763e-05	47.0	COG0265@1|root,COG0750@1|root,COG0265@2|Bacteria,COG0750@2|Bacteria,2IXR8@203682|Planctomycetes	203682|Planctomycetes	MO	MucD-putative a secreted serine proteinase	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Thioredoxin_7
CMS3_k127_2151817_0	1382306.JNIM01000001_gene3662	4.506e-30	132.0	COG1595@1|root,COG1595@2|Bacteria,2G93G@200795|Chloroflexi	200795|Chloroflexi	K	RNA polymerase, sigma-24 subunit, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_2151817_1	1133850.SHJG_5032	3.033e-26	115.0	COG0346@1|root,COG0346@2|Bacteria,2IFUM@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	cadI	GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_2155868_1	246197.MXAN_6260	5.504e-91	309.0	COG2345@1|root,COG2345@2|Bacteria,1MXT0@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
CMS3_k127_2155868_0	483219.LILAB_15180	1.95e-144	469.0	COG3344@1|root,COG3344@2|Bacteria,1R44F@1224|Proteobacteria,42WGB@68525|delta/epsilon subdivisions,2WQ7V@28221|Deltaproteobacteria,2YXI7@29|Myxococcales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	RVT_1
CMS3_k127_215598_1	1540221.JQNI01000004_gene124	3.304e-13	76.0	COG1246@1|root,COG1246@2|Bacteria,1WMRV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the acetyltransferase family. ArgA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_215598_0	1479235.KK366039_gene2925	1.77e-27	121.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,1XK0T@135619|Oceanospirillales	135619|Oceanospirillales	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4
CMS3_k127_2158439_1	284031.JNXD01000011_gene906	1.061e-31	141.0	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria	201174|Actinobacteria	F	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,WD40
CMS3_k127_2158439_0	521011.Mpal_0942	4.92e-104	353.0	COG1232@1|root,arCOG01522@2157|Archaea,2XY37@28890|Euryarchaeota	28890|Euryarchaeota	H	PFAM amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
CMS3_k127_2158608_1	497964.CfE428DRAFT_5038	3.728e-42	158.0	COG1520@1|root,COG1520@2|Bacteria,46T0C@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
CMS3_k127_2158608_0	1403819.BATR01000137_gene4831	1.268e-102	353.0	COG0438@1|root,COG0438@2|Bacteria,46UG2@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_2161866_0	1229204.AMYY01000011_gene154	4.531e-76	293.0	2DVRP@1|root,33WWS@2|Bacteria,1NWJ6@1224|Proteobacteria,2USDD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2161866_1	1515746.HR45_00395	1.435e-54	205.0	COG2304@1|root,COG2304@2|Bacteria,1N4IM@1224|Proteobacteria	1224|Proteobacteria	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like,VWA,VWA_2,VWA_3
CMS3_k127_216463_0	1123242.JH636435_gene2121	5.257e-320	1029.0	28KJF@1|root,2Z84W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2171140_3	314230.DSM3645_19638	1.151e-12	80.0	COG0810@1|root,COG0810@2|Bacteria,2J05E@203682|Planctomycetes	203682|Planctomycetes	M	NPCBM/NEW2 domain	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM
CMS3_k127_2171140_0	521674.Plim_2928	3.968e-209	664.0	COG0459@1|root,COG0459@2|Bacteria,2IWZS@203682|Planctomycetes	203682|Planctomycetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS3_k127_2171140_2	1210884.HG799470_gene14375	8.357e-32	127.0	COG0234@1|root,COG0234@2|Bacteria,2J0E5@203682|Planctomycetes	203682|Planctomycetes	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	-	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
CMS3_k127_2171140_1	671143.DAMO_2457	6.349e-45	165.0	COG0459@1|root,COG0459@2|Bacteria,2NNM6@2323|unclassified Bacteria	2|Bacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS3_k127_2172980_1	1121033.AUCF01000003_gene3267	1.106e-24	106.0	COG2411@1|root,COG2411@2|Bacteria,1N0KG@1224|Proteobacteria,2UCPX@28211|Alphaproteobacteria,2JX0N@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2172980_0	1041146.ATZB01000008_gene2192	6.349e-279	870.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
CMS3_k127_2176807_0	69395.JQLZ01000009_gene1880	7.223e-56	204.0	29525@1|root,2ZSEY@2|Bacteria,1RF0P@1224|Proteobacteria,2U90Q@28211|Alphaproteobacteria,2KGM5@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2178053_0	1267533.KB906733_gene3472	5.825e-108	372.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,TPR_8
CMS3_k127_2178053_1	314230.DSM3645_11631	8.571e-44	164.0	COG1595@1|root,COG1595@2|Bacteria,2J3FS@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS3_k127_2195589_4	6087.XP_002164266.2	6.566e-16	91.0	COG0457@1|root,KOG1124@2759|Eukaryota,38CY4@33154|Opisthokonta,3BDZ9@33208|Metazoa	33208|Metazoa	S	calcium ion homeostasis	TMTC2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0008150,GO:0012505,GO:0016020,GO:0031984,GO:0042175,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0048878,GO:0050801,GO:0055065,GO:0055074,GO:0055080,GO:0065007,GO:0065008,GO:0072507,GO:0098771,GO:0098827	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_1,TPR_16,TPR_2,TPR_8
CMS3_k127_2195589_5	439235.Dalk_1881	1.116e-15	91.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,1R092@1224|Proteobacteria,43CRV@68525|delta/epsilon subdivisions,2X7ZG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_2195589_0	500153.JOEK01000009_gene5221	1.889e-147	489.0	COG3540@1|root,COG3540@2|Bacteria,2IMZY@201174|Actinobacteria	201174|Actinobacteria	P	PhoD-like phosphatase	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD
CMS3_k127_2195589_1	243090.RB3330	4.659e-118	393.0	COG0673@1|root,COG0673@2|Bacteria,2IXFW@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_2195589_2	1406840.Q763_06375	6.253e-62	226.0	COG0644@1|root,COG0644@2|Bacteria,4NE67@976|Bacteroidetes,1HYEN@117743|Flavobacteriia,2NTJI@237|Flavobacterium	976|Bacteroidetes	C	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Lycopene_cycl,SE,Trp_halogenase
CMS3_k127_2195589_3	324602.Caur_0649	1.334e-49	193.0	COG1404@1|root,COG4447@1|root,COG1404@2|Bacteria,COG4447@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
CMS3_k127_2201898_1	1487953.JMKF01000045_gene2899	8.56e-61	216.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	tri	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
CMS3_k127_2201898_0	1123242.JH636434_gene3234	1.136e-142	469.0	COG2027@1|root,COG2027@2|Bacteria,2IYAC@203682|Planctomycetes	203682|Planctomycetes	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
CMS3_k127_2205099_0	1307761.L21SP2_0730	7.55e-243	779.0	COG0008@1|root,COG0008@2|Bacteria,2J6KU@203691|Spirochaetes	203691|Spirochaetes	J	Glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
CMS3_k127_2205099_7	1123261.AXDW01000021_gene838	2.8e-07	59.0	2BYAB@1|root,32R2Z@2|Bacteria,1QCT6@1224|Proteobacteria,1T8K3@1236|Gammaproteobacteria,1XAVH@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2205099_3	1403819.BATR01000191_gene6554	4.889e-97	324.0	COG1028@1|root,COG1028@2|Bacteria,46UWE@74201|Verrucomicrobia,2IVF3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	IQ	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_2205099_1	313603.FB2170_08789	1.798e-114	376.0	COG0179@1|root,COG0179@2|Bacteria,4NFMZ@976|Bacteroidetes,1HYU7@117743|Flavobacteriia,2PG2K@252356|Maribacter	976|Bacteroidetes	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
CMS3_k127_2205099_6	203275.BFO_2526	1.32e-30	128.0	COG3254@1|root,COG3254@2|Bacteria,4NQQ9@976|Bacteroidetes,2FTDQ@200643|Bacteroidia,22Z1W@171551|Porphyromonadaceae	976|Bacteroidetes	G	L-rhamnose mutarotase	-	-	5.1.3.32	ko:K03534	-	-	R10819	RC00563	ko00000,ko01000	-	-	-	rhaM
CMS3_k127_2205099_2	1380391.JIAS01000011_gene4704	1.068e-101	342.0	COG0673@1|root,COG0673@2|Bacteria,1PCQM@1224|Proteobacteria,2U32X@28211|Alphaproteobacteria,2JV4M@204441|Rhodospirillales	204441|Rhodospirillales	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_2205099_4	497964.CfE428DRAFT_0337	1.486e-89	302.0	COG3618@1|root,COG3618@2|Bacteria,46SN7@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Amidohydrolase	-	-	-	ko:K07046	ko00051,ko01120,map00051,map01120	-	R10689	RC00537	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
CMS3_k127_2205099_5	574376.BAMA_20505	3.601e-57	209.0	COG4912@1|root,COG4912@2|Bacteria,1TSAW@1239|Firmicutes,4HM25@91061|Bacilli,1ZDKZ@1386|Bacillus	91061|Bacilli	L	DNA alkylation repair	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
CMS3_k127_2209033_0	344747.PM8797T_26205	5.895e-177	578.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	DUF1863,PQQ,PQQ_2,PQQ_3
CMS3_k127_2209033_1	82654.Pse7367_2979	1.118e-21	110.0	COG2319@1|root,COG2319@2|Bacteria,1GKHN@1117|Cyanobacteria,1HFV2@1150|Oscillatoriales	1117|Cyanobacteria	S	Wd-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2211987_0	457570.Nther_2497	5.057e-141	472.0	COG1086@1|root,COG1086@2|Bacteria,1TR3W@1239|Firmicutes,247PW@186801|Clostridia	186801|Clostridia	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_syn_2C,Polysacc_synt_2
CMS3_k127_2217735_1	880526.KE386488_gene1576	2.632e-91	333.0	COG0823@1|root,COG0823@2|Bacteria,4NIGD@976|Bacteroidetes,2G2P7@200643|Bacteroidia	976|Bacteroidetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2217735_0	583355.Caka_0526	8.495e-104	357.0	COG1649@1|root,COG1649@2|Bacteria	2|Bacteria	F	PFAM Uncharacterised BCR, COG1649	-	-	3.2.1.11,3.2.1.18,3.2.1.35,4.2.2.23	ko:K01186,ko:K01197,ko:K05988,ko:K11931,ko:K18197	ko00500,ko00511,ko00531,ko00600,ko01100,ko02026,ko04142,map00500,map00511,map00531,map00600,map01100,map02026,map04142	M00076,M00077	R04018,R07824,R07825,R10905,R11309	RC00028,RC00077	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042	-	GH33,GH66,PL11	-	DUF1349,GHL10,Glyco_hydro_20b,Laminin_G_3,NAGidase,fn3
CMS3_k127_2228236_1	948106.AWZT01000006_gene3186	1.463e-13	83.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2WFGA@28216|Betaproteobacteria,1KGRF@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM polysaccharide export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
CMS3_k127_2228236_2	675806.VII_002881	6.16e-09	68.0	COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria,1RQWW@1236|Gammaproteobacteria,1XSTD@135623|Vibrionales	135623|Vibrionales	M	COG3307 Lipid A core - O-antigen ligase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
CMS3_k127_2228773_1	1089550.ATTH01000001_gene1008	5.564e-38	158.0	COG2304@1|root,COG2304@2|Bacteria,4NDUC@976|Bacteroidetes,1FIMW@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	von Willebrand factor type A domain	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
CMS3_k127_2228773_3	1396418.BATQ01000160_gene4907	6.568e-08	65.0	2DQN8@1|root,337RD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2228773_0	316274.Haur_4903	1.519e-70	250.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_2228773_2	247490.KSU1_C0857	3.103e-18	84.0	COG0714@1|root,COG0714@2|Bacteria,2IX23@203682|Planctomycetes	203682|Planctomycetes	S	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_2230460_5	331869.BAL199_26502	1.301e-20	96.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria,4BP88@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
CMS3_k127_2230460_2	379066.GAU_1725	6.987e-45	177.0	COG0134@1|root,COG0134@2|Bacteria,1ZTMA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Indole-3-glycerol phosphate synthase	-	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
CMS3_k127_2230460_4	498848.TaqDRAFT_5059	1.338e-23	111.0	COG0135@1|root,COG0135@2|Bacteria,1WINR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
CMS3_k127_2230460_0	1254432.SCE1572_07860	2.461e-139	454.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2WJJA@28221|Deltaproteobacteria,2YU86@29|Myxococcales	28221|Deltaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_2230460_3	1236541.BALL01000001_gene223	1.952e-43	179.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,2QA01@267890|Shewanellaceae	1236|Gammaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	iECED1_1282.ECED1_1467,iECP_1309.ECP_1308	Trp_syntA
CMS3_k127_2230460_1	1128421.JAGA01000002_gene125	1.981e-107	357.0	COG2876@1|root,COG2876@2|Bacteria,2NNPG@2323|unclassified Bacteria	2|Bacteria	E	PFAM DAHP synthetase I KDSA	aroG-1	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
CMS3_k127_2232772_1	596152.DesU5LDRAFT_3547	0.0004566	43.0	COG0438@1|root,COG0438@2|Bacteria,1NTNW@1224|Proteobacteria,42Z8E@68525|delta/epsilon subdivisions,2WTUS@28221|Deltaproteobacteria,2M8UN@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2232772_0	266834.SM_b20973	3.271e-260	834.0	COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria,1MX0Y@1224|Proteobacteria,2TRAZ@28211|Alphaproteobacteria,4BM4R@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	APH,Aminotran_3,Peptidase_M23
CMS3_k127_2234441_0	575540.Isop_1218	1.748e-44	163.0	COG3119@1|root,COG3119@2|Bacteria,2IXQ5@203682|Planctomycetes	203682|Planctomycetes	P	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_2234441_4	1128421.JAGA01000002_gene758	3.141e-08	66.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF2974,DUF4214,FKBP_C,HCBP_related,HemolysinCabind,Lipase_3,Peptidase_M10,Peptidase_M10_C
CMS3_k127_2234441_1	519989.ECTPHS_11090	1.273e-31	144.0	COG0583@1|root,COG0583@2|Bacteria,1NSNV@1224|Proteobacteria,1RPNG@1236|Gammaproteobacteria,1X2E5@135613|Chromatiales	135613|Chromatiales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
CMS3_k127_2234441_3	298653.Franean1_2436	2.981e-13	78.0	COG2197@1|root,COG2197@2|Bacteria,2IKVZ@201174|Actinobacteria,4EV6Q@85013|Frankiales	201174|Actinobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS3_k127_2252834_1	1142394.PSMK_21930	5.773e-70	253.0	COG1127@1|root,COG1127@2|Bacteria,2J2WI@203682|Planctomycetes	203682|Planctomycetes	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
CMS3_k127_2252834_3	335543.Sfum_2450	6.645e-47	186.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MR1@68525|delta/epsilon subdivisions,2WKC9@28221|Deltaproteobacteria,2MQXR@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
CMS3_k127_2252834_7	1096769.Pelub83DRAFT_1233	4.081e-11	74.0	COG1366@1|root,COG1366@2|Bacteria,1NNVE@1224|Proteobacteria	1224|Proteobacteria	T	transporter antisigma-factor antagonist STAS	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
CMS3_k127_2252834_5	2340.JV46_19820	7.136e-14	80.0	COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,1RQIY@1236|Gammaproteobacteria,1JA7R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	GAF,GAF_2,HATPase_c_2,PAS,SpoIIE
CMS3_k127_2252834_2	756272.Plabr_1790	3.338e-53	200.0	COG2208@1|root,COG2208@2|Bacteria,2J3F6@203682|Planctomycetes	203682|Planctomycetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
CMS3_k127_2252834_0	1125863.JAFN01000001_gene473	8.868e-107	364.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42NH8@68525|delta/epsilon subdivisions,2WJMA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
CMS3_k127_2252834_8	208439.AJAP_09890	1.182e-07	59.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4E5Y2@85010|Pseudonocardiales	201174|Actinobacteria	L	Belongs to the UPF0102 family	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
CMS3_k127_2252834_6	1033738.CAEP01000039_gene4050	1.075e-13	79.0	COG1862@1|root,COG1862@2|Bacteria,1VEMC@1239|Firmicutes,4HNK0@91061|Bacilli,26FRM@186818|Planococcaceae	91061|Bacilli	U	Preprotein translocase subunit YajC	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
CMS3_k127_2252834_4	1210884.HG799462_gene7789	1.983e-42	159.0	COG0482@1|root,COG0482@2|Bacteria,2IXFF@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
CMS3_k127_2254552_1	344747.PM8797T_14244	5.058e-31	131.0	2DVZ6@1|root,32V0F@2|Bacteria,2J01K@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2254552_0	521674.Plim_0730	7.568e-34	146.0	COG1030@1|root,COG1030@2|Bacteria,2IWTY@203682|Planctomycetes	203682|Planctomycetes	O	ClpP class	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD,SDH_sah
CMS3_k127_2261097_4	886293.Sinac_2367	6.272e-18	98.0	COG0699@1|root,COG0699@2|Bacteria,2J0G9@203682|Planctomycetes	203682|Planctomycetes	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
CMS3_k127_2261097_0	886293.Sinac_2368	2.245e-143	475.0	COG0699@1|root,COG0699@2|Bacteria,2J0DU@203682|Planctomycetes	203682|Planctomycetes	S	ATPase. Has a role at an early stage in the morphogenesis of the spore coat	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
CMS3_k127_2261097_1	1191523.MROS_1801	7.54e-99	338.0	COG0621@1|root,COG0621@2|Bacteria	2|Bacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	yqeV	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
CMS3_k127_2261097_2	555779.Dthio_PD3818	1.045e-93	325.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WKXU@28221|Deltaproteobacteria,2M80I@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CMS3_k127_2261097_3	331678.Cphamn1_0585	1.99e-89	317.0	COG0747@1|root,COG0747@2|Bacteria,1FD6U@1090|Chlorobi	1090|Chlorobi	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_2262755_0	335543.Sfum_1438	4.218e-191	618.0	COG0342@1|root,COG0537@1|root,COG1061@1|root,COG3886@1|root,COG0342@2|Bacteria,COG0537@2|Bacteria,COG1061@2|Bacteria,COG3886@2|Bacteria,1MV9F@1224|Proteobacteria,42NS1@68525|delta/epsilon subdivisions,2WQXY@28221|Deltaproteobacteria,2MS5Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HIT,Helicase_C,PLDc_2,ResIII
CMS3_k127_228283_1	1158318.ATXC01000001_gene640	1.294e-46	179.0	COG4902@1|root,COG4902@2|Bacteria	2|Bacteria	-	-	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	DUF2202
CMS3_k127_228283_2	1347086.CCBA010000007_gene4533	1.375e-25	112.0	2DNQ4@1|root,32YIU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SUKH_6
CMS3_k127_228283_0	251221.35214024	3.934e-149	494.0	COG0591@1|root,COG0591@2|Bacteria,1G1JV@1117|Cyanobacteria	1117|Cyanobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	-	-	-	-	-	-	-	-	-	SSF
CMS3_k127_2294498_1	886293.Sinac_2439	5.306e-197	625.0	COG3391@1|root,COG3511@1|root,COG3391@2|Bacteria,COG3511@2|Bacteria,2IX7F@203682|Planctomycetes	203682|Planctomycetes	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,Phosphoesterase
CMS3_k127_2294498_8	935863.AWZR01000001_gene1914	1.282e-14	87.0	COG0666@1|root,COG0666@2|Bacteria,1RBYV@1224|Proteobacteria,1SE9G@1236|Gammaproteobacteria,1X3VM@135614|Xanthomonadales	135614|Xanthomonadales	S	ankyrin repeat	ank2	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_4,Ank_5
CMS3_k127_2294498_5	331869.BAL199_23542	4.728e-62	222.0	COG5482@1|root,COG5482@2|Bacteria,1MWIN@1224|Proteobacteria,2TS4R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative PD-(D/E)XK phosphodiesterase (DUF2161)	MA20_28540	-	-	-	-	-	-	-	-	-	-	-	DUF2161
CMS3_k127_2294498_7	335543.Sfum_2462	1.821e-21	99.0	COG0346@1|root,COG0346@2|Bacteria,1P708@1224|Proteobacteria,432H7@68525|delta/epsilon subdivisions,2WXRS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2294498_6	71139.XP_010047234.1	1.57e-26	126.0	COG4886@1|root,2RZBH@2759|Eukaryota	2759|Eukaryota	S	regulation of response to stimulus	-	-	-	-	-	-	-	-	-	-	-	-	LRR_5,NB-ARC,TIR
CMS3_k127_2294498_4	350058.Mvan_1098	4.73e-93	336.0	COG0419@1|root,COG0419@2|Bacteria,2HU6Q@201174|Actinobacteria,2393E@1762|Mycobacteriaceae	201174|Actinobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23
CMS3_k127_2294498_9	693746.OBV_13210	2.553e-08	65.0	COG0420@1|root,COG0420@2|Bacteria,1TWMI@1239|Firmicutes,24BN3@186801|Clostridia,2N6XC@216572|Oscillospiraceae	186801|Clostridia	L	Calcineurin-like phosphoesterase	-	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
CMS3_k127_2294498_0	1123354.AUDR01000011_gene1417	3.859e-229	748.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VJSI@28216|Betaproteobacteria,1KT3X@119069|Hydrogenophilales	119069|Hydrogenophilales	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
CMS3_k127_2294498_10	595460.RRSWK_05017	4.012e-06	53.0	COG1595@1|root,COG1595@2|Bacteria,2J3UT@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_2294498_3	1123508.JH636444_gene5476	1.953e-167	550.0	COG5316@1|root,COG5316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
CMS3_k127_2294498_2	1192034.CAP_7351	9.568e-195	647.0	COG0665@1|root,COG4676@1|root,COG0665@2|Bacteria,COG4676@2|Bacteria,1QX8E@1224|Proteobacteria,43C1H@68525|delta/epsilon subdivisions,2X7C5@28221|Deltaproteobacteria,2YUS8@29|Myxococcales	28221|Deltaproteobacteria	E	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2135,VIT,VWA_3
CMS3_k127_2304723_1	1499967.BAYZ01000153_gene1551	9.246e-122	442.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,A2M_recep,CarboxypepD_reg,Plug,Thiol-ester_cl
CMS3_k127_2304723_2	1297617.JPJD01000082_gene1045	5.467e-10	68.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,267T4@186813|unclassified Clostridiales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
CMS3_k127_2304723_0	1123508.JH636443_gene4835	7.26e-135	437.0	COG0451@1|root,COG0451@2|Bacteria,2IZ0M@203682|Planctomycetes	203682|Planctomycetes	GM	Polysaccharide biosynthesis protein	-	-	1.1.1.203	ko:K18981	ko00053,map00053	-	R10841	RC00066	ko00000,ko00001,ko01000	-	-	-	Epimerase
CMS3_k127_2304723_3	644076.SCH4B_2479	1.42e-06	52.0	COG2900@1|root,COG2900@2|Bacteria,1N7YP@1224|Proteobacteria,2UFXX@28211|Alphaproteobacteria,4NCRU@97050|Ruegeria	28211|Alphaproteobacteria	S	SlyX	-	-	-	ko:K03745	-	-	-	-	ko00000	-	-	-	SlyX
CMS3_k127_2306935_2	1278073.MYSTI_06132	5.395e-45	167.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	iron-sulfur binding	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS3_k127_2306935_0	483219.LILAB_35260	2.405e-205	651.0	COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,2YU0I@29|Myxococcales	28221|Deltaproteobacteria	C	Polysulphide reductase, NrfD	actC	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
CMS3_k127_2306935_3	246197.MXAN_5555	1.38e-37	162.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	actD	-	-	-	-	-	-	-	-	-	-	-	DUF3341
CMS3_k127_2306935_4	1278073.MYSTI_06129	1.405e-25	114.0	COG2010@1|root,COG2010@2|Bacteria,1RHGQ@1224|Proteobacteria,42XMG@68525|delta/epsilon subdivisions,2WSJM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
CMS3_k127_2306935_1	1297742.A176_05066	1.727e-74	266.0	COG4531@1|root,COG4531@2|Bacteria,1REHQ@1224|Proteobacteria,42TZ1@68525|delta/epsilon subdivisions,2WQ6N@28221|Deltaproteobacteria,2YY91@29|Myxococcales	28221|Deltaproteobacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2306935_5	344747.PM8797T_29278	7.581e-09	59.0	COG2223@1|root,COG2223@2|Bacteria,2IYP8@203682|Planctomycetes	203682|Planctomycetes	P	Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
CMS3_k127_2310997_1	1206731.BAGB01000012_gene2754	0.0005507	51.0	COG0477@1|root,COG4932@1|root,COG0477@2|Bacteria,COG4932@2|Bacteria,2GJ09@201174|Actinobacteria,4FU8S@85025|Nocardiaceae	201174|Actinobacteria	EGP	the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,MFS_1
CMS3_k127_2310997_0	1298880.AUEV01000008_gene2265	4.184e-30	130.0	COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	cbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
CMS3_k127_2311074_0	290397.Adeh_3302	4.946e-140	453.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,4376B@68525|delta/epsilon subdivisions,2X25W@28221|Deltaproteobacteria,2YZ9U@29|Myxococcales	28221|Deltaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
CMS3_k127_2311373_1	2074.JNYD01000023_gene1313	0.0001431	54.0	COG0443@1|root,COG3391@1|root,COG0443@2|Bacteria,COG3391@2|Bacteria,2GNTE@201174|Actinobacteria,4EEDS@85010|Pseudonocardiales	201174|Actinobacteria	O	MreB/Mbl protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
CMS3_k127_2311373_0	1123258.AQXZ01000018_gene668	2.677e-56	216.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	-	-	1.3.99.23,5.2.1.13	ko:K09516,ko:K09835	ko00830,ko00906,ko01100,ko01110,map00830,map00906,map01100,map01110	M00097	R07163,R07512	RC01835,RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
CMS3_k127_2313457_1	324602.Caur_3201	2.337e-46	169.0	COG0243@1|root,COG0243@2|Bacteria,2G5ZB@200795|Chloroflexi,37670@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS3_k127_2313457_2	1304275.C41B8_18191	2.652e-33	139.0	COG3381@1|root,COG3381@2|Bacteria	2|Bacteria	S	protein complex oligomerization	dmsD	GO:0001539,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006928,GO:0006950,GO:0006974,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0033554,GO:0040011,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0071944,GO:0071973,GO:0071978,GO:0097588,GO:0098552,GO:0098562	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
CMS3_k127_2313457_3	1157490.EL26_00705	1.745e-24	115.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,4HC4H@91061|Bacilli,278E6@186823|Alicyclobacillaceae	91061|Bacilli	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
CMS3_k127_2313457_4	1177928.TH2_10324	0.0001727	48.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2JQJT@204441|Rhodospirillales	204441|Rhodospirillales	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
CMS3_k127_2313457_0	497964.CfE428DRAFT_5213	4.998e-206	653.0	COG4650@1|root,COG4650@2|Bacteria,46TFD@74201|Verrucomicrobia	74201|Verrucomicrobia	KT	Regulator of RNA terminal phosphate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	RtcR,Sigma54_activat
CMS3_k127_2313963_2	1125863.JAFN01000001_gene537	5.414e-06	59.0	COG0438@1|root,COG0438@2|Bacteria,1RCUU@1224|Proteobacteria,42R1N@68525|delta/epsilon subdivisions,2WN4T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_2313963_3	32049.SYNPCC7002_A2553	5.684e-06	59.0	COG0457@1|root,COG0457@2|Bacteria,1G0BJ@1117|Cyanobacteria,1GZ50@1129|Synechococcus	1117|Cyanobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
CMS3_k127_2313963_1	882083.SacmaDRAFT_5556	3.259e-06	60.0	COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria,4E1H1@85010|Pseudonocardiales	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_2313963_0	1121920.AUAU01000004_gene745	1.717e-20	98.0	COG0506@1|root,COG0506@2|Bacteria,3Y2G8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
CMS3_k127_2316642_2	59374.Fisuc_1952	6.207e-21	95.0	COG3536@1|root,COG3536@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF971)	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	DUF971
CMS3_k127_2316642_1	580332.Slit_2664	5.898e-22	104.0	COG0746@1|root,COG0746@2|Bacteria,1PJ8F@1224|Proteobacteria,2VYU6@28216|Betaproteobacteria,44WA2@713636|Nitrosomonadales	28216|Betaproteobacteria	H	MobA-like NTP transferase domain	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS3_k127_2316642_0	215358.XP_010737264.1	1.035e-44	177.0	COG2103@1|root,2QS2J@2759|Eukaryota,38ECQ@33154|Opisthokonta,3BF6B@33208|Metazoa,3CZ2P@33213|Bilateria,489SP@7711|Chordata,496D1@7742|Vertebrata,49VCS@7898|Actinopterygii	33208|Metazoa	S	Glucokinase (hexokinase 4) regulator	GCKR	GO:0000060,GO:0001678,GO:0003674,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006109,GO:0006110,GO:0006140,GO:0006606,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0006913,GO:0008104,GO:0008150,GO:0008152,GO:0009593,GO:0009730,GO:0009732,GO:0009743,GO:0009746,GO:0009749,GO:0009750,GO:0009889,GO:0009892,GO:0009893,GO:0009894,GO:0009987,GO:0010033,GO:0010562,GO:0010563,GO:0010675,GO:0010676,GO:0010677,GO:0010906,GO:0015031,GO:0015833,GO:0017038,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019725,GO:0019899,GO:0019904,GO:0030234,GO:0030246,GO:0030808,GO:0030811,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031329,GO:0031974,GO:0031981,GO:0033036,GO:0033131,GO:0033132,GO:0033133,GO:0033365,GO:0033500,GO:0033673,GO:0033674,GO:0034284,GO:0034287,GO:0034504,GO:0034613,GO:0034641,GO:0042221,GO:0042325,GO:0042326,GO:0042327,GO:0042592,GO:0042593,GO:0042886,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043467,GO:0043470,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0045912,GO:0045913,GO:0045936,GO:0045937,GO:0046415,GO:0046483,GO:0046907,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048878,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051169,GO:0051170,GO:0051171,GO:0051174,GO:0051179,GO:0051193,GO:0051196,GO:0051234,GO:0051338,GO:0051347,GO:0051348,GO:0051594,GO:0051606,GO:0051641,GO:0051649,GO:0055082,GO:0055088,GO:0055090,GO:0062012,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070095,GO:0070328,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0072521,GO:0072594,GO:0080090,GO:0097367,GO:0098772,GO:1900371,GO:1900542,GO:1901360,GO:1901564,GO:1901700,GO:1903299,GO:1903300,GO:1903301,GO:1903578,GO:2001169	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2339092_2	1267533.KB906740_gene214	4.968e-48	176.0	COG0058@1|root,COG0058@2|Bacteria,3Y65H@57723|Acidobacteria,2JM98@204432|Acidobacteriia	204432|Acidobacteriia	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
CMS3_k127_2339092_1	1158760.AQXP01000026_gene20	6.724e-165	537.0	COG0433@1|root,COG0561@1|root,COG0433@2|Bacteria,COG0561@2|Bacteria,1P5B8@1224|Proteobacteria	1224|Proteobacteria	S	Haloacid dehalogenase domain protein hydrolase, type 3	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
CMS3_k127_2339092_0	886293.Sinac_6584	4.004e-166	542.0	COG0249@1|root,COG0249@2|Bacteria,2IXGV@203682|Planctomycetes	203682|Planctomycetes	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
CMS3_k127_2349449_0	713587.THITH_08540	7.4e-134	432.0	COG0702@1|root,COG0702@2|Bacteria,1N12V@1224|Proteobacteria,1S93R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
CMS3_k127_2349449_1	886293.Sinac_4157	6.51e-44	171.0	COG4233@1|root,COG4233@2|Bacteria,2J49W@203682|Planctomycetes	203682|Planctomycetes	CO	Disulphide bond corrector protein DsbC	-	-	-	-	-	-	-	-	-	-	-	-	DsbC
CMS3_k127_2351496_0	1210884.HG799471_gene14563	1.938e-69	265.0	COG0515@1|root,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_2351496_1	344747.PM8797T_02854	7.33e-20	100.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
CMS3_k127_2353820_0	1267533.KB906733_gene3472	1.956e-83	297.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,TPR_8
CMS3_k127_2353820_1	1121288.AULL01000017_gene2313	0.0002307	54.0	COG4447@1|root,COG4447@2|Bacteria,4PM0K@976|Bacteroidetes,1I2DM@117743|Flavobacteriia,3ZRT1@59732|Chryseobacterium	976|Bacteroidetes	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
CMS3_k127_2353910_0	373994.Riv7116_1662	4.026e-110	379.0	COG2072@1|root,COG2072@2|Bacteria,1GBHZ@1117|Cyanobacteria	1117|Cyanobacteria	P	flavoprotein involved in K transport	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2366322_2	472759.Nhal_3750	4.379e-41	153.0	COG5340@1|root,COG5340@2|Bacteria,1P6MT@1224|Proteobacteria,1RN7A@1236|Gammaproteobacteria,1WXZZ@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator, AbiEi antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4
CMS3_k127_2366322_0	472759.Nhal_3749	9.971e-115	383.0	COG2253@1|root,COG2253@2|Bacteria,1NJT9@1224|Proteobacteria,1S0YI@1236|Gammaproteobacteria,1WXVW@135613|Chromatiales	135613|Chromatiales	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS3_k127_2366322_1	1123389.ATXJ01000007_gene1772	1.041e-46	185.0	COG0399@1|root,COG0399@2|Bacteria,1WJBP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS3_k127_2366322_3	573063.Metin_0395	4.158e-19	100.0	COG0392@1|root,arCOG00899@2157|Archaea,2XUZK@28890|Euryarchaeota	28890|Euryarchaeota	S	integral membrane protein	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS3_k127_2366322_4	748247.AZKH_0386	1.806e-13	74.0	COG0859@1|root,COG0859@2|Bacteria,1PRP7@1224|Proteobacteria,2VMYH@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
CMS3_k127_2366608_2	448385.sce9102	8.385e-06	50.0	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,4360E@68525|delta/epsilon subdivisions,2X0HX@28221|Deltaproteobacteria,2Z0TS@29|Myxococcales	28221|Deltaproteobacteria	L	High confidence in function and specificity	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
CMS3_k127_2366608_0	314230.DSM3645_28142	2.091e-67	250.0	COG3316@1|root,COG3316@2|Bacteria,2J4XX@203682|Planctomycetes	203682|Planctomycetes	L	IS66 C-terminal element	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
CMS3_k127_2366608_1	448385.sce9102	4.219e-24	105.0	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,4360E@68525|delta/epsilon subdivisions,2X0HX@28221|Deltaproteobacteria,2Z0TS@29|Myxococcales	28221|Deltaproteobacteria	L	High confidence in function and specificity	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
CMS3_k127_2370836_0	283942.IL0367	2.971e-38	164.0	COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MVNC@1224|Proteobacteria,1RQGJ@1236|Gammaproteobacteria,2QEYZ@267893|Idiomarinaceae	1236|Gammaproteobacteria	NU	biogenesis protein MshL	mshL	-	-	ko:K12282	-	-	-	-	ko00000,ko02044	-	-	-	STN,Secretin,Secretin_N_2
CMS3_k127_2385054_0	3055.EDP05215	4.27e-24	105.0	COG1104@1|root,KOG1549@2759|Eukaryota,37Y59@33090|Viridiplantae,34J7J@3041|Chlorophyta	3041|Chlorophyta	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_2385054_1	1207063.P24_12936	5.761e-11	77.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VEWM@28211|Alphaproteobacteria,2JYMT@204441|Rhodospirillales	204441|Rhodospirillales	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_2385054_2	316058.RPB_0428	8.171e-07	61.0	28JYF@1|root,2Z9NQ@2|Bacteria,1MXUQ@1224|Proteobacteria,2TS50@28211|Alphaproteobacteria,3JV8F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	MA20_24600	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2387823_2	595460.RRSWK_00694	6.345e-20	96.0	COG0515@1|root,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_2387823_1	1089551.KE386572_gene2884	9.36e-39	165.0	COG1572@1|root,COG1572@2|Bacteria,1RF0V@1224|Proteobacteria	1224|Proteobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Metallopep,PKD,Peptidase_M10
CMS3_k127_2387823_3	1123242.JH636437_gene5945	1.246e-13	82.0	COG1595@1|root,COG1595@2|Bacteria,2IZFC@203682|Planctomycetes	203682|Planctomycetes	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ECF,Sigma70_r2,Sigma70_r4_2
CMS3_k127_2387823_5	765914.ThisiDRAFT_2729	3.111e-10	64.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
CMS3_k127_2387823_7	593105.S7A_20194	2.897e-06	49.0	COG0178@1|root,COG0178@2|Bacteria,1MX79@1224|Proteobacteria,1RYSZ@1236|Gammaproteobacteria,3W018@53335|Pantoea	1236|Gammaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS3_k127_2387823_6	639030.JHVA01000001_gene1145	1.673e-06	58.0	COG1595@1|root,COG1595@2|Bacteria,3Y4CA@57723|Acidobacteria,2JJ0Z@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_2387823_0	595460.RRSWK_01928	5.409e-44	178.0	COG0515@1|root,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,WD40
CMS3_k127_2400144_1	530564.Psta_0406	9.419e-09	67.0	COG2304@1|root,COG2304@2|Bacteria,2IY1T@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA,VWA_3
CMS3_k127_2400144_0	530564.Psta_2754	2.501e-47	175.0	COG2755@1|root,COG2755@2|Bacteria,2IWTR@203682|Planctomycetes	2|Bacteria	E	sialic acid-specific 9-O-acetylesterase	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	SASA
CMS3_k127_2412314_2	631362.Thi970DRAFT_03186	1.984e-06	53.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,1X0B5@135613|Chromatiales	135613|Chromatiales	M	Transposase zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
CMS3_k127_2412314_1	1408452.JAGZ01000001_gene3091	1.079e-08	58.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,235Z8@1762|Mycobacteriaceae	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS3_k127_2412314_0	370438.PTH_2559	1.298e-19	100.0	COG4636@1|root,COG4636@2|Bacteria,1V60G@1239|Firmicutes,24HUW@186801|Clostridia,261ZJ@186807|Peptococcaceae	186801|Clostridia	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
CMS3_k127_2413003_0	649638.Trad_0638	4.869e-167	537.0	COG1132@1|root,COG1132@2|Bacteria,1WMBB@1297|Deinococcus-Thermus	2|Bacteria	V	COGs COG1132 ABC-type multidrug transport system ATPase and permease components	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_2413003_1	1142394.PSMK_06840	3.931e-155	498.0	COG0673@1|root,COG0673@2|Bacteria,2IWTD@203682|Planctomycetes	203682|Planctomycetes	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_2413854_0	234267.Acid_7369	9.619e-82	281.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria	57723|Acidobacteria	S	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS3_k127_2413854_1	756272.Plabr_0410	8.251e-52	193.0	COG5587@1|root,COG5587@2|Bacteria,2J2RK@203682|Planctomycetes	203682|Planctomycetes	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
CMS3_k127_2418876_2	1501230.ET33_04985	1.377e-35	147.0	28HPB@1|root,2Z7XC@2|Bacteria,1VMJ8@1239|Firmicutes,4IUEI@91061|Bacilli,26U5M@186822|Paenibacillaceae	91061|Bacilli	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase,Hepar_II_III
CMS3_k127_2418876_1	344747.PM8797T_06150	1.858e-129	426.0	28J2H@1|root,2Z8YZ@2|Bacteria,2IWTN@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2418876_0	1129794.C427_1223	2.389e-130	451.0	COG2706@1|root,COG3391@1|root,COG3637@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,COG3637@2|Bacteria,1QWRQ@1224|Proteobacteria,1T4S3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2424247_1	661478.OP10G_4286	7.22e-23	106.0	2EKVR@1|root,33EJ9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2424247_0	156889.Mmc1_3432	1.908e-86	291.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria	1224|Proteobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
CMS3_k127_2424247_3	861299.J421_3551	1.607e-07	64.0	COG0823@1|root,COG0823@2|Bacteria,1ZTBK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
CMS3_k127_2424247_2	926560.KE387023_gene3326	1.213e-07	62.0	COG4257@1|root,COG4257@2|Bacteria	2|Bacteria	V	antibiotic catabolic process	vgb	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	DUF5011
CMS3_k127_2431932_0	1254432.SCE1572_24570	9.761e-49	201.0	COG1858@1|root,COG2706@1|root,COG3391@1|root,COG1858@2|Bacteria,COG2706@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,438GV@68525|delta/epsilon subdivisions,2X3RP@28221|Deltaproteobacteria,2YWY2@29|Myxococcales	28221|Deltaproteobacteria	P	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2431932_1	936375.HMPREF1152_1812	3.777e-17	92.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,3WD6P@538999|Clostridiales incertae sedis	186801|Clostridia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
CMS3_k127_2433430_0	34506.g6021	0.0003495	55.0	COG0124@1|root,KOG1936@2759|Eukaryota,3A22K@33154|Opisthokonta,3CQX3@33208|Metazoa,3DDC6@33213|Bilateria	33208|Metazoa	J	Histidyl-tRNA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_His
CMS3_k127_2435790_0	756272.Plabr_4342	1.264e-78	277.0	COG0052@1|root,COG0052@2|Bacteria,2IY9P@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
CMS3_k127_2435790_1	404589.Anae109_3583	5.147e-38	163.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42M4Q@68525|delta/epsilon subdivisions,2X5DU@28221|Deltaproteobacteria,2YVAA@29|Myxococcales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0069	GGDEF,Response_reg
CMS3_k127_2435790_2	316274.Haur_0249	1.247e-07	64.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,2GBRR@200795|Chloroflexi,376B2@32061|Chloroflexia	32061|Chloroflexia	D	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like,VWA,VWA_2
CMS3_k127_2439529_1	1449068.JMLQ01000001_gene721	7.943e-06	48.0	COG1321@1|root,COG1321@2|Bacteria,2I42V@201174|Actinobacteria,4G2X6@85025|Nocardiaceae	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2439529_0	864051.BurJ1DRAFT_0665	1.138e-94	325.0	COG1819@1|root,COG1819@2|Bacteria,1MVI7@1224|Proteobacteria,2VRHM@28216|Betaproteobacteria,1KMT3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_28,UDPGT
CMS3_k127_2444372_0	2045.KR76_23425	1.433e-155	505.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DPQN@85009|Propionibacteriales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
CMS3_k127_2444372_1	1231392.OCGS_2370	1.378e-21	102.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF559,SpoU_methylase
CMS3_k127_2454730_0	138119.DSY4123	1.061e-59	225.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,24HDS@186801|Clostridia,260SB@186807|Peptococcaceae	186801|Clostridia	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
CMS3_k127_2454730_1	290397.Adeh_3524	6.871e-07	61.0	COG1404@1|root,COG1572@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,1REF1@1224|Proteobacteria,42RS0@68525|delta/epsilon subdivisions,2WNDK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Peptidase_S8
CMS3_k127_2455952_1	1122621.ATZA01000002_gene1586	3.759e-12	78.0	COG0420@1|root,COG0420@2|Bacteria,4NEET@976|Bacteroidetes,1IPQS@117747|Sphingobacteriia	976|Bacteroidetes	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
CMS3_k127_2455952_0	414684.RC1_0099	2.564e-107	386.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2TUMR@28211|Alphaproteobacteria,2JR41@204441|Rhodospirillales	204441|Rhodospirillales	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3883,Helicase_C,SNF2_N
CMS3_k127_2455952_2	329726.AM1_3304	3.64e-11	67.0	COG1357@1|root,COG1357@2|Bacteria,1G5EE@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2,Pentapeptide,TerD
CMS3_k127_2460515_7	330214.NIDE3281	1.442e-12	80.0	2AKTZ@1|root,31BM1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2460515_5	797210.Halxa_3204	5.74e-25	118.0	arCOG01506@1|root,arCOG01506@2157|Archaea,2XVS5@28890|Euryarchaeota,23SUT@183963|Halobacteria	183963|Halobacteria	S	component of anaerobic	-	-	-	ko:K03533	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	5.A.3.4	-	-	Nitrate_red_del
CMS3_k127_2460515_1	330214.NIDE3236	1.069e-179	571.0	COG1140@1|root,COG1140@2|Bacteria,3J1FU@40117|Nitrospirae	2|Bacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	ddhB	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.5.1	ko:K00371,ko:K16965,ko:K17048,ko:K17051	ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020	M00529,M00530,M00804	R00798,R01106,R05745,R09497,R09500	RC00275,RC02555,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8,5.A.3.9	-	-	Fer4_11
CMS3_k127_2460515_0	247490.KSU1_B0257	0.0	1593.0	COG0243@1|root,COG0243@2|Bacteria,2J2QN@203682|Planctomycetes	203682|Planctomycetes	C	Molybdopterin oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin
CMS3_k127_2460515_2	1379698.RBG1_1C00001G0011	8.051e-85	302.0	COG2010@1|root,COG2180@1|root,COG2010@2|Bacteria,COG2180@2|Bacteria,2NR8D@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c	narJ	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057	-	ko:K00373,ko:K00405,ko:K17052	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko02000	3.D.4.3,5.A.3.8	-	iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687	Nitrate_red_del
CMS3_k127_2460515_9	566466.NOR53_2459	2.151e-10	73.0	2F075@1|root,33TAN@2|Bacteria,1NU7P@1224|Proteobacteria,1SMVW@1236|Gammaproteobacteria,1J9CN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2460515_3	485913.Krac_5903	4.757e-79	285.0	COG0210@1|root,COG0210@2|Bacteria,2GA78@200795|Chloroflexi	200795|Chloroflexi	L	PFAM NERD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NERD
CMS3_k127_2460515_6	314230.DSM3645_24877	4.974e-22	100.0	2EDA6@1|root,3376M@2|Bacteria,2J0KG@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2460515_4	314230.DSM3645_24872	7.364e-33	138.0	COG1396@1|root,COG1396@2|Bacteria,2J17Z@203682|Planctomycetes	203682|Planctomycetes	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_37
CMS3_k127_2460515_8	1122194.AUHU01000002_gene2935	1.183e-11	78.0	COG3012@1|root,COG3012@2|Bacteria	2|Bacteria	-	-	CP_0501	-	-	ko:K07039	-	-	-	-	ko00000	-	-	-	HTH_psq,SEC-C
CMS3_k127_2470374_0	378806.STAUR_3209	4.359e-21	109.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_2470374_1	1380355.JNIJ01000009_gene1793	1.333e-19	93.0	COG0764@1|root,COG0764@2|Bacteria,1RJND@1224|Proteobacteria,2UA4J@28211|Alphaproteobacteria,3JYDB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	FabA-like domain	-	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
CMS3_k127_2477380_1	47839.CCAU010000008_gene2105	8.663e-19	100.0	COG4262@1|root,COG4262@2|Bacteria,2GK41@201174|Actinobacteria,234MR@1762|Mycobacteriaceae	201174|Actinobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
CMS3_k127_2477380_0	485917.Phep_1133	7.6e-46	179.0	COG1262@1|root,COG1262@2|Bacteria,4NEUZ@976|Bacteroidetes,1IPZV@117747|Sphingobacteriia	976|Bacteroidetes	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT,FGE-sulfatase
CMS3_k127_2477380_2	530564.Psta_4120	2.221e-11	67.0	COG0673@1|root,COG0673@2|Bacteria,2IYHX@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_2500221_1	1123242.JH636434_gene4958	6.065e-36	139.0	COG1312@1|root,COG1312@2|Bacteria,2IXAA@203682|Planctomycetes	203682|Planctomycetes	G	D-mannonate dehydratase (UxuA)	-	-	-	-	-	-	-	-	-	-	-	-	UxuA
CMS3_k127_2500221_0	1192034.CAP_7351	1.515e-266	856.0	COG0665@1|root,COG4676@1|root,COG0665@2|Bacteria,COG4676@2|Bacteria,1QX8E@1224|Proteobacteria,43C1H@68525|delta/epsilon subdivisions,2X7C5@28221|Deltaproteobacteria,2YUS8@29|Myxococcales	28221|Deltaproteobacteria	E	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2135,VIT,VWA_3
CMS3_k127_2500864_0	530564.Psta_2516	9.215e-75	255.0	COG0457@1|root,COG0457@2|Bacteria,2IZEP@203682|Planctomycetes	203682|Planctomycetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2500864_2	1396141.BATP01000003_gene5009	1.224e-55	211.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Calx-beta,He_PIG,Laminin_G_3,PKD,PPC,RHS_repeat
CMS3_k127_2500864_1	1128427.KB904821_gene441	7.175e-74	255.0	COG0474@1|root,COG0474@2|Bacteria,1G4BB@1117|Cyanobacteria,1H7WQ@1150|Oscillatoriales	1117|Cyanobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
CMS3_k127_2502265_4	794846.AJQU01000039_gene4917	7.952e-06	49.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS3_k127_2502265_2	886293.Sinac_5462	1.405e-55	211.0	COG0438@1|root,COG0438@2|Bacteria,2IYYZ@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_2502265_1	765913.ThidrDRAFT_4388	3.065e-70	253.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RYBJ@1236|Gammaproteobacteria,1WZFQ@135613|Chromatiales	135613|Chromatiales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_2502265_3	237368.SCABRO_03387	5.104e-19	103.0	COG1269@1|root,COG1269@2|Bacteria,2IZU8@203682|Planctomycetes	203682|Planctomycetes	C	PFAM Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
CMS3_k127_2502265_0	338966.Ppro_2470	1.098e-78	282.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,42P7W@68525|delta/epsilon subdivisions,2WMHU@28221|Deltaproteobacteria,43SFF@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Domain of unknown function (DUF3473)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
CMS3_k127_2504155_2	1120966.AUBU01000010_gene2953	7.137e-06	57.0	COG2133@1|root,COG3291@1|root,COG4654@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG4654@2|Bacteria,4PNA4@976|Bacteroidetes,47YAQ@768503|Cytophagia	976|Bacteroidetes	CG	Glucose / Sorbosone dehydrogenase	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	CBM_6,Cytochrom_C,GSDH,PKD,ThuA
CMS3_k127_2504155_1	1226994.AMZB01000079_gene128	1.931e-18	93.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1YDJ6@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	iAF1260.b1912,iAPECO1_1312.APECO1_954,iB21_1397.B21_01866,iBWG_1329.BWG_1721,iE2348C_1286.E2348C_2030,iEC042_1314.EC042_2073,iEC55989_1330.EC55989_2132,iECABU_c1320.ECABU_c21710,iECBD_1354.ECBD_1731,iECB_1328.ECB_01877,iECDH10B_1368.ECDH10B_2053,iECDH1ME8569_1439.ECDH1ME8569_1852,iECD_1391.ECD_01877,iECED1_1282.ECED1_2177,iECH74115_1262.ECH74115_2684,iECIAI1_1343.ECIAI1_1996,iECIAI39_1322.ECIAI39_1143,iECNA114_1301.ECNA114_2003,iECO103_1326.ECO103_2168,iECO111_1330.ECO111_2492,iECO26_1355.ECO26_2804,iECOK1_1307.ECOK1_2029,iECP_1309.ECP_1852,iECS88_1305.ECS88_1966,iECSF_1327.ECSF_1764,iECSP_1301.ECSP_2516,iECUMN_1333.ECUMN_2204,iECs_1301.ECs2650,iETEC_1333.ETEC_2020,iEcDH1_1363.EcDH1_1734,iEcE24377_1341.EcE24377A_2145,iEcHS_1320.EcHS_A2010,iEcSMS35_1347.EcSMS35_1271,iEcolC_1368.EcolC_1727,iG2583_1286.G2583_2363,iJO1366.b1912,iJR904.b1912,iLF82_1304.LF82_1635,iNRG857_1313.NRG857_09550,iSDY_1059.SDY_1106,iSSON_1240.SSON_1206,iSbBS512_1146.SbBS512_E1039,iUMN146_1321.UM146_07620,iUMNK88_1353.UMNK88_2386,iUTI89_1310.UTI89_C2113,iY75_1357.Y75_RS10025,iYL1228.KPN_02410,iZ_1308.Z3000,ic_1306.c2325	CDP-OH_P_transf
CMS3_k127_2504155_0	324057.Pjdr2_1476	5.939e-102	342.0	COG1240@1|root,COG1240@2|Bacteria	2|Bacteria	H	magnesium chelatase activity	bchD	-	6.6.1.1	ko:K03404,ko:K07114	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
CMS3_k127_2519322_1	530564.Psta_2509	6.188e-79	278.0	COG3541@1|root,COG3541@2|Bacteria,2IY2V@203682|Planctomycetes	203682|Planctomycetes	S	Predicted nucleotidyltransferase	-	-	-	ko:K07074	-	-	-	-	ko00000	-	-	-	Nuc-transf
CMS3_k127_2519322_0	243090.RB9591	6.389e-96	323.0	COG3541@1|root,COG3541@2|Bacteria,2IXJ3@203682|Planctomycetes	203682|Planctomycetes	S	Predicted nucleotidyltransferase	-	-	-	ko:K07074	-	-	-	-	ko00000	-	-	-	Nuc-transf
CMS3_k127_2519322_2	324602.Caur_0649	2.645e-33	140.0	COG1404@1|root,COG4447@1|root,COG1404@2|Bacteria,COG4447@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
CMS3_k127_2521015_1	1122176.KB903571_gene4786	5.957e-10	72.0	COG0457@1|root,COG0457@2|Bacteria,4NMZG@976|Bacteroidetes,1IZUU@117747|Sphingobacteriia	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_16,TPR_2,TPR_8
CMS3_k127_2521015_2	517417.Cpar_1643	1.368e-06	59.0	COG1051@1|root,COG1051@2|Bacteria,1FDZM@1090|Chlorobi	1090|Chlorobi	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
CMS3_k127_2521015_0	404589.Anae109_0837	1.986e-60	222.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,42QRC@68525|delta/epsilon subdivisions,2WMP7@28221|Deltaproteobacteria,2YUHQ@29|Myxococcales	28221|Deltaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
CMS3_k127_2523599_0	111781.Lepto7376_2808	1.917e-31	141.0	COG0705@1|root,COG0705@2|Bacteria,1G1Z3@1117|Cyanobacteria,1H857@1150|Oscillatoriales	1117|Cyanobacteria	S	(Rhomboid) family	-	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
CMS3_k127_2523636_2	118173.KB235914_gene183	2.999e-50	186.0	COG0500@1|root,COG2226@2|Bacteria,1G0W5@1117|Cyanobacteria,1H8EK@1150|Oscillatoriales	1117|Cyanobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
CMS3_k127_2523636_0	926566.Terro_0195	6.808e-174	576.0	COG0308@1|root,COG0308@2|Bacteria,3Y6V6@57723|Acidobacteria,2JMGB@204432|Acidobacteriia	204432|Acidobacteriia	E	ERAP1-like C-terminal domain	-	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
CMS3_k127_2523636_4	497964.CfE428DRAFT_1473	0.0009872	52.0	COG0457@1|root,COG0457@2|Bacteria,46V1N@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_11,TPR_16,TPR_2,TPR_8
CMS3_k127_2523636_1	933262.AXAM01000099_gene212	7.812e-125	411.0	COG1373@1|root,COG1373@2|Bacteria,1R9U4@1224|Proteobacteria,42ZPX@68525|delta/epsilon subdivisions,2WV2B@28221|Deltaproteobacteria,2MND9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
CMS3_k127_2523636_3	1121940.AUDZ01000007_gene2159	3.822e-07	57.0	COG0625@1|root,COG0625@2|Bacteria,1RAIN@1224|Proteobacteria,1S3Q5@1236|Gammaproteobacteria,1XKHU@135619|Oceanospirillales	135619|Oceanospirillales	O	Belongs to the GST superfamily	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
CMS3_k127_2530297_0	96561.Dole_2977	2.245e-137	451.0	COG1373@1|root,COG1373@2|Bacteria,1MWDX@1224|Proteobacteria,42Q61@68525|delta/epsilon subdivisions,2WM4W@28221|Deltaproteobacteria,2MJEU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS3_k127_2532209_0	243090.RB7008	2.425e-98	338.0	COG2262@1|root,COG2262@2|Bacteria,2IXH5@203682|Planctomycetes	203682|Planctomycetes	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
CMS3_k127_2532209_1	344747.PM8797T_12558	4.171e-56	204.0	COG0029@1|root,COG0029@2|Bacteria,2IY30@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CMS3_k127_2536055_0	316067.Geob_0789	4.276e-56	201.0	COG3155@1|root,COG3155@2|Bacteria,1MW2K@1224|Proteobacteria,42R54@68525|delta/epsilon subdivisions,2WMNZ@28221|Deltaproteobacteria,43U43@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	PFAM ThiJ PfpI domain protein	elbB	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
CMS3_k127_2536055_1	68170.KL590553_gene5146	3.76e-47	190.0	COG4188@1|root,COG4188@2|Bacteria,2GJVV@201174|Actinobacteria,4E4T2@85010|Pseudonocardiales	201174|Actinobacteria	S	Platelet-activating factor acetylhydrolase, isoform II	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
CMS3_k127_2539083_0	1120956.JHZK01000027_gene1193	2.554e-79	275.0	COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,2UAN7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	UbiA prenyltransferase family	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
CMS3_k127_2560469_1	1123226.KB899284_gene3793	1.658e-10	68.0	COG5036@1|root,COG5036@2|Bacteria,1V1FZ@1239|Firmicutes,4HEFT@91061|Bacilli,26RUQ@186822|Paenibacillaceae	91061|Bacilli	P	VTC domain	-	-	-	-	-	-	-	-	-	-	-	-	VTC
CMS3_k127_2560469_0	1049564.TevJSym_az00020	1.218e-27	121.0	COG1285@1|root,COG1285@2|Bacteria,1PD3I@1224|Proteobacteria,1RQXT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
CMS3_k127_2560469_2	1122604.JONR01000009_gene2466	5.521e-06	58.0	COG1566@1|root,COG1566@2|Bacteria,1MXZV@1224|Proteobacteria,1S2IJ@1236|Gammaproteobacteria,1X764@135614|Xanthomonadales	135614|Xanthomonadales	V	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	HlyD_D23
CMS3_k127_2561479_0	234267.Acid_0825	4.355e-30	134.0	COG3746@1|root,COG3746@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2561479_1	883078.HMPREF9695_00157	5.671e-10	68.0	COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,2TQTF@28211|Alphaproteobacteria,3JRQN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the bacterial solute-binding protein 9 family	znuA	-	-	ko:K02077,ko:K09815	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
CMS3_k127_2562627_0	379066.GAU_2854	4.855e-94	328.0	COG2866@1|root,COG2866@2|Bacteria,1ZT9V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS3_k127_2562627_3	404589.Anae109_2553	4.233e-30	123.0	COG3411@1|root,COG3411@2|Bacteria,1RM68@1224|Proteobacteria,42TUK@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2562627_4	653733.Selin_1526	6.093e-28	121.0	COG4399@1|root,COG4399@2|Bacteria	2|Bacteria	-	-	yheB	-	-	-	-	-	-	-	-	-	-	-	DUF445
CMS3_k127_2562627_2	319225.Plut_0262	4.142e-30	130.0	COG0543@1|root,COG0543@2|Bacteria,1FDWW@1090|Chlorobi	1090|Chlorobi	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6
CMS3_k127_2562627_1	880072.Desac_0610	4.183e-54	201.0	COG0863@1|root,COG0863@2|Bacteria,1R8XS@1224|Proteobacteria	1224|Proteobacteria	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
CMS3_k127_2564484_0	1254432.SCE1572_41910	6.053e-131	451.0	COG2274@1|root,COG3271@1|root,COG2274@2|Bacteria,COG3271@2|Bacteria,1R2T0@1224|Proteobacteria,43BXM@68525|delta/epsilon subdivisions,2X78E@28221|Deltaproteobacteria,2YUMW@29|Myxococcales	28221|Deltaproteobacteria	V	Peptidase C39 family	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran,Peptidase_C39
CMS3_k127_2564484_1	448385.sce7173	2.02e-27	118.0	COG1566@1|root,COG1566@2|Bacteria,1Q1MT@1224|Proteobacteria,437CC@68525|delta/epsilon subdivisions,2X2HX@28221|Deltaproteobacteria,2YUXQ@29|Myxococcales	28221|Deltaproteobacteria	V	HlyD family secretion protein	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_3
CMS3_k127_2564484_2	448385.sce7173	2.06e-10	69.0	COG1566@1|root,COG1566@2|Bacteria,1Q1MT@1224|Proteobacteria,437CC@68525|delta/epsilon subdivisions,2X2HX@28221|Deltaproteobacteria,2YUXQ@29|Myxococcales	28221|Deltaproteobacteria	V	HlyD family secretion protein	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_3
CMS3_k127_2564484_3	981383.AEWH01000024_gene2625	5.005e-07	59.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	sigX	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_2565506_10	1121933.AUHH01000008_gene1121	4.533e-05	55.0	COG4412@1|root,COG4412@2|Bacteria,2GMKQ@201174|Actinobacteria	201174|Actinobacteria	M	PFAM peptidase M6, immune inhibitor A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
CMS3_k127_2565506_1	344747.PM8797T_27864	4.983e-136	458.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_2565506_6	1121382.JQKG01000013_gene452	1.715e-65	232.0	COG3361@1|root,COG3361@2|Bacteria	2|Bacteria	S	conserved protein (COG2071)	wcoQ	-	-	ko:K09166	-	-	-	-	ko00000	-	-	-	DUF2071
CMS3_k127_2565506_5	1303518.CCALI_02044	3.894e-115	384.0	2EE91@1|root,3383F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2565506_7	1217718.ALOU01000007_gene1258	6.508e-62	223.0	COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2W0N2@28216|Betaproteobacteria	28216|Betaproteobacteria	O	PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase_2
CMS3_k127_2565506_9	1120977.JHUX01000003_gene1072	1.415e-05	57.0	COG0241@1|root,COG0241@2|Bacteria,1QWZ2@1224|Proteobacteria,1T30P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	D,D-heptose 1,7-bisphosphate phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
CMS3_k127_2565506_8	926567.TheveDRAFT_0743	3.162e-51	206.0	COG2804@1|root,COG2804@2|Bacteria,3T9WP@508458|Synergistetes	508458|Synergistetes	NU	type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
CMS3_k127_2565506_2	1123508.JH636441_gene3371	6.952e-132	433.0	COG0448@1|root,COG0448@2|Bacteria,2IXP5@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CMS3_k127_2565506_4	352165.HMPREF7215_1005	7.218e-120	411.0	COG3408@1|root,COG3408@2|Bacteria,3TAE3@508458|Synergistetes	508458|Synergistetes	G	glycogen debranching enzyme, archaeal type	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
CMS3_k127_2565506_3	352165.HMPREF7215_1007	2.641e-131	433.0	COG1449@1|root,COG1449@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	amyA	-	3.2.1.1	ko:K07405	ko00500,ko01100,map00500,map01100	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH57	-	Glyco_hydro_57
CMS3_k127_2565506_0	1322246.BN4_20183	8.605e-160	529.0	COG0058@1|root,COG0438@1|root,COG0058@2|Bacteria,COG0438@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,2M7US@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Glycosyl transferase, family 35	glgP	-	2.4.1.1,2.4.1.11	ko:K00688,ko:K16153	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R00292,R02111	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT3,GT35	-	DUF3417,Glycogen_syn,Phosphorylase
CMS3_k127_2569579_2	1120942.AUBM01000007_gene620	6.446e-05	52.0	2CC6E@1|root,33CIM@2|Bacteria,2GYWJ@201174|Actinobacteria,4D5DY@85005|Actinomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2569579_0	344747.PM8797T_29708	4.211e-153	492.0	COG4409@1|root,COG4409@2|Bacteria,2IYPT@203682|Planctomycetes	2|Bacteria	G	BNR repeat-like domain	-	-	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Big_2,DUF4091,FIVAR,Laminin_G_3
CMS3_k127_2569579_1	595460.RRSWK_01940	8.344e-131	437.0	COG3119@1|root,COG3119@2|Bacteria,2IX9T@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS3_k127_2569579_3	208960.XP_007263316.1	0.0003084	50.0	KOG0266@1|root,KOG0266@2759|Eukaryota	2759|Eukaryota	B	WD repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	WD40
CMS3_k127_2583195_3	1321773.HMPREF9069_00282	1.549e-09	71.0	COG0642@1|root,COG2205@2|Bacteria,2I2QY@201174|Actinobacteria,4CUCM@84998|Coriobacteriia	84998|Coriobacteriia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_2583195_2	1192034.CAP_0904	5.726e-26	119.0	2A4R8@1|root,30TCM@2|Bacteria,1PD5K@1224|Proteobacteria,43DYZ@68525|delta/epsilon subdivisions,2WZ8R@28221|Deltaproteobacteria,2Z1KF@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TerB
CMS3_k127_2583195_1	1297617.JPJD01000029_gene2325	1.087e-90	307.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,267XU@186813|unclassified Clostridiales	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_2583195_0	626887.J057_21235	1.33e-108	370.0	COG2017@1|root,COG2017@2|Bacteria,1MVMN@1224|Proteobacteria,1RNZN@1236|Gammaproteobacteria,464QA@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Converts alpha-aldose to the beta-anomer	galM	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
CMS3_k127_259218_0	215803.DB30_5381	2.461e-59	231.0	COG0470@1|root,COG0470@2|Bacteria,1R6KM@1224|Proteobacteria	1224|Proteobacteria	L	DNA polymerase III	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2
CMS3_k127_259218_1	1123508.JH636442_gene4325	6.491e-57	211.0	COG5534@1|root,COG5534@2|Bacteria	2|Bacteria	L	Replication initiator protein	-	-	-	-	-	-	-	-	-	-	-	-	RPA
CMS3_k127_259218_2	243230.DR_0013	1.828e-27	123.0	COG1192@1|root,COG1192@2|Bacteria,1WIIX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	D	involved in chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS3_k127_2592810_3	864051.BurJ1DRAFT_0135	6.441e-31	129.0	COG2815@1|root,COG2815@2|Bacteria,1RK04@1224|Proteobacteria,2VSGS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
CMS3_k127_2592810_2	1348657.M622_17245	5.479e-37	151.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,GUN4,GUN4_N,Peptidase_C13,Peptidase_C14
CMS3_k127_2592810_5	671143.DAMO_2125	4.222e-24	106.0	COG0724@1|root,COG0724@2|Bacteria,2NPT0@2323|unclassified Bacteria	2|Bacteria	S	RNA recognition motif	rbpD	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS3_k127_2592810_0	330214.NIDE0843	1.57e-261	824.0	COG1032@1|root,COG1032@2|Bacteria,3J18Y@40117|Nitrospirae	40117|Nitrospirae	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS3_k127_2592810_4	1317122.ATO12_08385	1.899e-29	126.0	COG3043@1|root,COG3043@2|Bacteria,4NG82@976|Bacteroidetes,1HZDY@117743|Flavobacteriia,2YHZ9@290174|Aquimarina	976|Bacteroidetes	C	Nitrate reductase cytochrome c-type subunit (NapB)	-	-	-	ko:K02568	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798	RC02812	ko00000,ko00001,ko00002	-	-	-	Cytochrome_C554,NapB
CMS3_k127_2592810_1	398767.Glov_1056	3.207e-170	542.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions,2WKKT@28221|Deltaproteobacteria,43VZF@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA NapA NarB subfamily	-	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
CMS3_k127_2595637_0	1123504.JQKD01000064_gene2478	8e-65	239.0	COG4850@1|root,COG4850@2|Bacteria,1R3ST@1224|Proteobacteria,2VX96@28216|Betaproteobacteria,4AG6P@80864|Comamonadaceae	28216|Betaproteobacteria	S	Uncharacterized conserved protein (DUF2183)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2183
CMS3_k127_2595637_2	1232410.KI421424_gene1769	1.057e-07	63.0	COG3637@1|root,COG3637@2|Bacteria,1RG1M@1224|Proteobacteria,42VR0@68525|delta/epsilon subdivisions,2WS4Z@28221|Deltaproteobacteria,43USG@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2595637_1	243090.RB3946	4.246e-37	155.0	COG3148@1|root,COG3148@2|Bacteria,2J4DM@203682|Planctomycetes	203682|Planctomycetes	S	DTW	-	-	-	ko:K05812	-	-	-	-	ko00000	-	-	-	DTW
CMS3_k127_2602712_0	1122179.KB890458_gene817	5.385e-47	185.0	COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,1IQ2M@117747|Sphingobacteriia	976|Bacteroidetes	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
CMS3_k127_2602712_1	160492.XF_0820	3.719e-07	60.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1RNNQ@1236|Gammaproteobacteria,1X4D8@135614|Xanthomonadales	135614|Xanthomonadales	S	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
CMS3_k127_2606109_1	1121451.DESAM_21836	2.742e-73	268.0	COG4267@1|root,COG4267@2|Bacteria,1MUQN@1224|Proteobacteria,42Q3G@68525|delta/epsilon subdivisions,2WKR6@28221|Deltaproteobacteria,2MAM4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative exopolysaccharide Exporter (EPS-E)	-	-	-	ko:K21012	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	PelG
CMS3_k127_2606109_0	1121451.DESAM_21835	5.103e-123	431.0	COG0438@1|root,COG0438@2|Bacteria,1MVEG@1224|Proteobacteria,42Q1K@68525|delta/epsilon subdivisions,2WJ1U@28221|Deltaproteobacteria,2M8XU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Domain of unknown function (DUF3492)	-	-	-	ko:K21011	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	DUF3492,Glycos_transf_1
CMS3_k127_2606109_2	1121451.DESAM_21833	8.632e-11	75.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1PZ3S@1224|Proteobacteria,435PM@68525|delta/epsilon subdivisions,2X03J@28221|Deltaproteobacteria,2MA9Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	ko:K21009	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	GAF_3
CMS3_k127_2607152_0	710696.Intca_0096	8.744e-153	511.0	COG0189@1|root,COG0189@2|Bacteria,2I75I@201174|Actinobacteria,4FEMX@85021|Intrasporangiaceae	201174|Actinobacteria	HJ	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	-	-	-	-	-	-	-	-	-	-	-	-	CPSase_L_D2
CMS3_k127_2607152_1	880073.Calab_3584	7.227e-152	494.0	COG0297@1|root,COG0297@2|Bacteria,2NQKG@2323|unclassified Bacteria	2|Bacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
CMS3_k127_2620108_5	483219.LILAB_27305	5.789e-15	82.0	COG4946@1|root,COG4946@2|Bacteria,1QX6N@1224|Proteobacteria,43BZD@68525|delta/epsilon subdivisions,2X7A4@28221|Deltaproteobacteria,2YWSC@29|Myxococcales	28221|Deltaproteobacteria	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2620108_4	1396141.BATP01000019_gene1646	5.405e-26	112.0	COG0640@1|root,COG0640@2|Bacteria,46T9N@74201|Verrucomicrobia	74201|Verrucomicrobia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
CMS3_k127_2620108_1	661478.OP10G_1195	4.654e-45	169.0	COG4978@1|root,COG4978@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
CMS3_k127_2620108_0	1210884.HG799464_gene10730	5.277e-54	194.0	COG3832@1|root,COG3832@2|Bacteria,2IZ84@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_2620108_3	97138.C820_00012	6.942e-27	116.0	COG5485@1|root,COG5485@2|Bacteria,1V4VN@1239|Firmicutes,24IWY@186801|Clostridia	186801|Clostridia	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
CMS3_k127_2620108_2	357808.RoseRS_0607	5.871e-35	135.0	COG2010@1|root,COG2010@2|Bacteria,2G6R3@200795|Chloroflexi,377DZ@32061|Chloroflexia	32061|Chloroflexia	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
CMS3_k127_2620451_0	1324957.K933_14128	1.08e-78	276.0	COG0153@1|root,arCOG01029@2157|Archaea,2XU7R@28890|Euryarchaeota,23TRG@183963|Halobacteria	183963|Halobacteria	G	Galactokinase galactose-binding signature	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
CMS3_k127_2620451_1	1133569.AHYZ01000060_gene880	1.986e-06	59.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,4HC85@91061|Bacilli,3F45W@33958|Lactobacillaceae	91061|Bacilli	M	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins	prsA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0006457,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3
CMS3_k127_2620882_0	756272.Plabr_0919	9.365e-99	340.0	COG1409@1|root,COG1409@2|Bacteria,2J2TN@203682|Planctomycetes	203682|Planctomycetes	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS3_k127_2625811_1	1267535.KB906767_gene1160	8.886e-31	139.0	COG2006@1|root,COG2006@2|Bacteria,3Y7N1@57723|Acidobacteria,2JNKP@204432|Acidobacteriia	204432|Acidobacteriia	S	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS3_k127_2625811_0	314230.DSM3645_05180	9.139e-73	268.0	COG2159@1|root,COG2159@2|Bacteria,2IYMW@203682|Planctomycetes	203682|Planctomycetes	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
CMS3_k127_2628785_0	518766.Rmar_1383	9.552e-108	372.0	COG2132@1|root,COG2132@2|Bacteria,4NE3N@976|Bacteroidetes	2|Bacteria	Q	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,DUF4396
CMS3_k127_2628785_1	1144275.COCOR_01521	1.703e-07	63.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,Cna_B
CMS3_k127_2628791_4	861299.J421_1365	4.395e-29	129.0	COG1680@1|root,COG1680@2|Bacteria,1ZTJS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_2628791_3	1384056.N787_02315	4.728e-30	139.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1X47B@135614|Xanthomonadales	135614|Xanthomonadales	S	DNA internalization-related competence protein ComEC Rec2	comA	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
CMS3_k127_2628791_2	1231241.Mc24_07779	1.319e-32	148.0	COG0669@1|root,COG0669@2|Bacteria,2GD05@200918|Thermotogae	200918|Thermotogae	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
CMS3_k127_2628791_1	269799.Gmet_2324	2.814e-40	160.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2WQ6E@28221|Deltaproteobacteria,43V3F@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
CMS3_k127_2628791_0	234267.Acid_3622	3.122e-71	265.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_2628791_5	1303518.CCALI_02808	1.156e-17	97.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2631262_0	530564.Psta_4579	3.455e-65	244.0	COG0673@1|root,COG0673@2|Bacteria,2IXDR@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_2639796_0	756272.Plabr_3086	0.0	1354.0	COG0841@1|root,COG0841@2|Bacteria,2J22R@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS3_k127_2639796_2	313596.RB2501_06070	4.842e-97	347.0	COG0845@1|root,COG0845@2|Bacteria,4NF0X@976|Bacteroidetes,1HY9N@117743|Flavobacteriia	976|Bacteroidetes	M	Efflux transporter, RND family, MFP subunit	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
CMS3_k127_2639796_1	1124780.ANNU01000032_gene1222	9.061e-101	346.0	COG1538@1|root,COG1538@2|Bacteria,4NDZK@976|Bacteroidetes,47XKT@768503|Cytophagia	976|Bacteroidetes	MU	Outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
CMS3_k127_2639796_3	1210884.HG799468_gene13802	1.299e-52	197.0	COG5267@1|root,COG5267@2|Bacteria,2IYR3@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
CMS3_k127_2642058_0	1210884.HG799466_gene12369	1.08e-06	62.0	COG0457@1|root,COG2010@1|root,COG2133@1|root,COG0457@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,2IXKV@203682|Planctomycetes	203682|Planctomycetes	C	Membrane-bound dehydrogenase domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
CMS3_k127_2642650_0	243090.RB12431	3.945e-187	597.0	COG3119@1|root,COG3119@2|Bacteria,2J20N@203682|Planctomycetes	203682|Planctomycetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_26463_0	1121405.dsmv_0232	9.653e-99	345.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43BS9@68525|delta/epsilon subdivisions,2X733@28221|Deltaproteobacteria,2MPJG@213118|Desulfobacterales	28221|Deltaproteobacteria	K	sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
CMS3_k127_26463_2	1207063.P24_08479	2.51e-51	186.0	COG0783@1|root,COG0783@2|Bacteria,1RAC5@1224|Proteobacteria,2U5Q5@28211|Alphaproteobacteria,2JS6E@204441|Rhodospirillales	204441|Rhodospirillales	P	Belongs to the Dps family	-	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
CMS3_k127_26463_1	48698.ENSPFOP00000011148	1.519e-54	201.0	COG0317@1|root,KOG1157@2759|Eukaryota,39Y6C@33154|Opisthokonta,3BNBB@33208|Metazoa,3CWZI@33213|Bilateria,4816Y@7711|Chordata,497H9@7742|Vertebrata,49QKW@7898|Actinopterygii	33208|Metazoa	T	HD domain containing 3	HDDC3	GO:0003674,GO:0003824,GO:0006139,GO:0006152,GO:0006163,GO:0006195,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008893,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009154,GO:0009164,GO:0009166,GO:0009259,GO:0009261,GO:0009605,GO:0009987,GO:0009991,GO:0015969,GO:0015971,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0031667,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034035,GO:0034037,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046128,GO:0046130,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901068,GO:1901069,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.7.2	ko:K21138	ko00230,map00230	-	R00336	RC00078	ko00000,ko00001,ko01000	-	-	-	HD_4
CMS3_k127_26463_4	861299.J421_1711	0.0001097	56.0	COG1629@1|root,COG1629@2|Bacteria,1ZTI4@142182|Gemmatimonadetes	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Caps_assemb_Wzi
CMS3_k127_26463_3	1306174.JODP01000005_gene1597	1.599e-05	59.0	COG1595@1|root,COG1595@2|Bacteria,2GKFQ@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_26463_5	543632.JOJL01000010_gene7041	0.000321	51.0	COG3664@1|root,COG3664@2|Bacteria,2GNRR@201174|Actinobacteria,4DH7Q@85008|Micromonosporales	201174|Actinobacteria	G	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,CBM_35,Laminin_G_3
CMS3_k127_2651645_1	1210884.HG799468_gene13825	4.053e-71	250.0	COG1352@1|root,COG1352@2|Bacteria,2IYFW@203682|Planctomycetes	203682|Planctomycetes	NT	PFAM MCP methyltransferase CheR-type	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
CMS3_k127_2651645_2	35754.JNYJ01000057_gene8671	4.452e-14	81.0	COG1406@1|root,COG1406@2|Bacteria,2IRB9@201174|Actinobacteria,4DMHQ@85008|Micromonosporales	201174|Actinobacteria	N	Chemotaxis phosphatase CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
CMS3_k127_2651645_0	41431.PCC8801_3596	0.0	1146.0	COG1413@1|root,COG1413@2|Bacteria,1G1H5@1117|Cyanobacteria,3KKAR@43988|Cyanothece	1117|Cyanobacteria	C	Domain of unknown function (DUF4132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132
CMS3_k127_2651705_0	396588.Tgr7_0704	0.0	1068.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
CMS3_k127_2651705_1	314275.MADE_1008800	7.644e-37	144.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,466HH@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
CMS3_k127_265188_0	1403819.BATR01000089_gene2616	2.23e-21	102.0	COG1520@1|root,COG1520@2|Bacteria,46TSY@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_2656183_1	575540.Isop_1648	9.829e-32	138.0	COG1657@1|root,COG1657@2|Bacteria,2IYCT@203682|Planctomycetes	203682|Planctomycetes	I	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
CMS3_k127_2656183_3	1297742.A176_07375	1.982e-05	56.0	COG4932@1|root,COG4932@2|Bacteria,1PEGG@1224|Proteobacteria,43854@68525|delta/epsilon subdivisions,2X3F3@28221|Deltaproteobacteria,2YVTB@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_2656183_0	391598.FBBAL38_09852	1.161e-131	447.0	COG1520@1|root,COG1520@2|Bacteria,4NHPR@976|Bacteroidetes,1HXXS@117743|Flavobacteriia	976|Bacteroidetes	G	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans
CMS3_k127_2656183_2	1384065.JAGS01000001_gene3122	1.825e-07	64.0	COG2304@1|root,COG4886@1|root,COG2304@2|Bacteria,COG4886@2|Bacteria,1VKTN@1239|Firmicutes	1239|Firmicutes	KLT	Lectin C-type domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Lectin_C
CMS3_k127_2664291_1	240016.ABIZ01000001_gene2571	1.583e-155	506.0	COG0492@1|root,COG1053@1|root,COG2755@1|root,COG4409@1|root,COG0492@2|Bacteria,COG1053@2|Bacteria,COG2755@2|Bacteria,COG4409@2|Bacteria,46TCP@74201|Verrucomicrobia,2IWKC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EG	Carbohydrate esterase, sialic acid-specific acetylesterase	-	-	-	-	-	-	-	-	-	-	-	-	SASA
CMS3_k127_2664291_0	765420.OSCT_1210	1.234e-168	551.0	COG0281@1|root,COG0281@2|Bacteria,2G65R@200795|Chloroflexi,376YS@32061|Chloroflexia	32061|Chloroflexia	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
CMS3_k127_2664291_4	240292.Ava_4115	1.468e-119	395.0	COG0334@1|root,COG0334@2|Bacteria,1G4HR@1117|Cyanobacteria,1HRGB@1161|Nostocales	1117|Cyanobacteria	C	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain	-	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_2664291_3	1069534.LRC_05070	5.183e-139	466.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,4HAFB@91061|Bacilli,3F44H@33958|Lactobacillaceae	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
CMS3_k127_2664291_2	665952.HMPREF1015_02484	2.453e-140	456.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,4HBAZ@91061|Bacilli,1ZAT1@1386|Bacillus	91061|Bacilli	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS3_k127_267191_0	1267533.KB906733_gene3472	9.707e-101	348.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,TPR_8
CMS3_k127_267191_1	314230.DSM3645_11631	3.363e-41	160.0	COG1595@1|root,COG1595@2|Bacteria,2J3FS@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS3_k127_267191_2	1121481.AUAS01000006_gene877	3.838e-24	119.0	COG1520@1|root,COG2931@1|root,COG5184@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,COG5184@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
CMS3_k127_2678733_3	1248917.ANFX01000030_gene553	3.366e-20	101.0	COG1988@1|root,COG1988@2|Bacteria,1RA9E@1224|Proteobacteria,2U5TK@28211|Alphaproteobacteria,2K3A3@204457|Sphingomonadales	204457|Sphingomonadales	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
CMS3_k127_2678733_1	886293.Sinac_7484	2.677e-51	192.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_2678733_0	1123065.ATWL01000006_gene2307	1.459e-115	401.0	COG1082@1|root,COG1082@2|Bacteria,2I94Z@201174|Actinobacteria	201174|Actinobacteria	G	BNR repeat-containing family member	-	-	-	-	-	-	-	-	-	-	-	-	BNR_4
CMS3_k127_2686433_1	1123242.JH636434_gene3906	9.584e-25	108.0	COG3682@1|root,COG3682@2|Bacteria,2J4IV@203682|Planctomycetes	203682|Planctomycetes	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS3_k127_2686433_0	1123242.JH636435_gene2777	1.815e-36	157.0	COG2319@1|root,COG4219@1|root,COG2319@2|Bacteria,COG4219@2|Bacteria,2IZRJ@203682|Planctomycetes	203682|Planctomycetes	KT	Antirepressor regulating drug resistance	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
CMS3_k127_2686433_2	153948.NAL212_1490	4.476e-05	52.0	COG3212@1|root,COG3212@2|Bacteria,1NPFE@1224|Proteobacteria,2WBME@28216|Betaproteobacteria,373E6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Putative beta-lactamase-inhibitor-like, PepSY-like	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_like
CMS3_k127_2686771_1	1120966.AUBU01000021_gene3052	0.0002307	53.0	COG4773@1|root,COG4773@2|Bacteria,4NF92@976|Bacteroidetes,47M11@768503|Cytophagia	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
CMS3_k127_2686771_0	1521187.JPIM01000133_gene1355	3.037e-10	66.0	COG0457@1|root,COG0457@2|Bacteria	1521187.JPIM01000133_gene1355|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2693030_0	1121121.KB894286_gene2447	2.403e-07	65.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	B_lectin,PPC
CMS3_k127_2696332_0	716544.wcw_0725	3.405e-216	690.0	COG3808@1|root,COG3808@2|Bacteria,2JFK4@204428|Chlamydiae	2|Bacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K01507,ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
CMS3_k127_2696332_2	742738.HMPREF9460_02768	3.298e-25	109.0	COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,24MVA@186801|Clostridia,2693I@186813|unclassified Clostridiales	186801|Clostridia	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
CMS3_k127_2696332_1	935948.KE386494_gene372	2.036e-97	340.0	COG1331@1|root,COG1331@2|Bacteria,1TPRD@1239|Firmicutes,248PD@186801|Clostridia,42FE6@68295|Thermoanaerobacterales	186801|Clostridia	O	COGs COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
CMS3_k127_2696332_4	313628.LNTAR_05166	8.192e-06	54.0	COG0542@1|root,COG0542@2|Bacteria	2|Bacteria	O	response to heat	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
CMS3_k127_2696332_3	671143.DAMO_0250	3.655e-08	62.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
CMS3_k127_2714776_0	1396418.BATQ01000007_gene1417	3.784e-103	354.0	COG2319@1|root,COG2319@2|Bacteria,46UXD@74201|Verrucomicrobia,2IV1H@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Protein of unknown function (DUF1549)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt2,PSD1
CMS3_k127_2716347_2	1449346.JQMO01000002_gene1629	3.379e-28	122.0	COG0451@1|root,COG0451@2|Bacteria,2HPPN@201174|Actinobacteria,2M0PY@2063|Kitasatospora	201174|Actinobacteria	GM	Male sterility protein	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
CMS3_k127_2716347_1	289376.THEYE_A0594	6.76e-152	490.0	COG0156@1|root,COG0156@2|Bacteria,3J0XU@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_2716347_0	370438.PTH_2220	6.2e-322	1024.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,2605R@186807|Peptococcaceae	186801|Clostridia	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
CMS3_k127_2728246_2	1429916.X566_13905	3.512e-07	61.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TSTS@28211|Alphaproteobacteria,3JVH6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	sfuB	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
CMS3_k127_2728246_0	1123023.JIAI01000015_gene3349	1.124e-53	202.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4E01K@85010|Pseudonocardiales	201174|Actinobacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.30	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	M00190,M00193	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11	-	-	ABC_tran,TOBE_2
CMS3_k127_2728246_1	502025.Hoch_2450	5.895e-12	78.0	COG3005@1|root,COG3005@2|Bacteria,1QXTY@1224|Proteobacteria,43C6F@68525|delta/epsilon subdivisions,2X7GN@28221|Deltaproteobacteria,2YVYJ@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
CMS3_k127_2733227_1	583355.Caka_0965	3.059e-08	64.0	COG0823@1|root,COG1413@1|root,COG0823@2|Bacteria,COG1413@2|Bacteria,46XCP@74201|Verrucomicrobia,3K9X8@414999|Opitutae	414999|Opitutae	U	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2733227_0	240015.ACP_1882	2.872e-124	414.0	COG0469@1|root,COG0469@2|Bacteria,3Y36V@57723|Acidobacteria,2JHY5@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
CMS3_k127_2737673_1	1123320.KB889698_gene9323	1.02e-11	77.0	COG2133@1|root,COG3055@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3055@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Calx-beta,GSDH,Laminin_G_3,Malectin,PKD
CMS3_k127_2737673_0	153948.NAL212_2837	1.198e-28	127.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	3.1.4.50	ko:K01127	ko00563,map00563	-	R06623	-	ko00000,ko00001,ko01000	-	-	-	Big_5,Calx-beta,FG-GAP,HemolysinCabind
CMS3_k127_2738915_0	1129794.C427_1223	2.021e-137	471.0	COG2706@1|root,COG3391@1|root,COG3637@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,COG3637@2|Bacteria,1QWRQ@1224|Proteobacteria,1T4S3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2738915_1	1123261.AXDW01000021_gene838	2.954e-43	164.0	2BYAB@1|root,32R2Z@2|Bacteria,1QCT6@1224|Proteobacteria,1T8K3@1236|Gammaproteobacteria,1XAVH@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2738915_2	517418.Ctha_1779	1.025e-05	51.0	COG0346@1|root,COG0346@2|Bacteria,1FE33@1090|Chlorobi	1090|Chlorobi	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
CMS3_k127_2743121_1	1382359.JIAL01000001_gene464	8.753e-94	315.0	COG0160@1|root,COG0160@2|Bacteria,3Y3P2@57723|Acidobacteria,2JIZJ@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_2743121_2	390989.JOEG01000004_gene3861	2.096e-58	206.0	COG1247@1|root,COG1247@2|Bacteria,2IHSY@201174|Actinobacteria,4DFX0@85008|Micromonosporales	201174|Actinobacteria	M	Acetyltransferase (GNAT) domain	bar	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
CMS3_k127_2743121_0	1047013.AQSP01000134_gene1356	3.227e-152	514.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2920,Peptidase_S9
CMS3_k127_2746650_0	247490.KSU1_D0480	3.511e-88	294.0	COG0740@1|root,COG0740@2|Bacteria,2IXQN@203682|Planctomycetes	203682|Planctomycetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
CMS3_k127_2746650_1	237368.SCABRO_03816	1.445e-45	182.0	COG0544@1|root,COG0544@2|Bacteria,2IXGD@203682|Planctomycetes	203682|Planctomycetes	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	Trigger_C,Trigger_N
CMS3_k127_2747989_0	863365.XHC_0147	9.016e-09	66.0	COG0457@1|root,COG0785@1|root,COG3710@1|root,COG0457@2|Bacteria,COG0785@2|Bacteria,COG3710@2|Bacteria,1QU0J@1224|Proteobacteria,1RY8Z@1236|Gammaproteobacteria,1X4K8@135614|Xanthomonadales	135614|Xanthomonadales	K	AAA ATPase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Trans_reg_C
CMS3_k127_2750097_1	1280954.HPO_06938	1.205e-10	71.0	COG0845@1|root,COG0845@2|Bacteria,1NJDF@1224|Proteobacteria,2TSZA@28211|Alphaproteobacteria,43XXZ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS3_k127_2750097_0	1123242.JH636435_gene1926	9.664e-33	134.0	COG1846@1|root,COG1846@2|Bacteria,2J0VK@203682|Planctomycetes	203682|Planctomycetes	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
CMS3_k127_2750097_2	69781.S8ANH9	0.0001557	54.0	KOG1274@1|root,KOG1274@2759|Eukaryota,38GB7@33154|Opisthokonta,3NW5X@4751|Fungi,3QJHD@4890|Ascomycota,20CIV@147545|Eurotiomycetes,3S895@5042|Eurotiales	4751|Fungi	S	Chromosome segregation protein (SepB)	mcl1	GO:0000070,GO:0000228,GO:0000278,GO:0000280,GO:0000724,GO:0000725,GO:0000727,GO:0000785,GO:0000790,GO:0000819,GO:0001302,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006271,GO:0006273,GO:0006281,GO:0006302,GO:0006310,GO:0006325,GO:0006342,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0007064,GO:0007568,GO:0007569,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016458,GO:0019219,GO:0019222,GO:0022402,GO:0022616,GO:0030702,GO:0031298,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031974,GO:0031981,GO:0032502,GO:0032991,GO:0033260,GO:0033554,GO:0033567,GO:0034085,GO:0034641,GO:0034645,GO:0040029,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043596,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044786,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0048285,GO:0048519,GO:0048523,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051276,GO:0051716,GO:0060255,GO:0061641,GO:0065007,GO:0070013,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0098813,GO:0140014,GO:1901360,GO:1901363,GO:1901576,GO:1902679,GO:1902969,GO:1903047,GO:1903461,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K11274	-	-	-	-	ko00000,ko03036	-	-	-	ANAPC4_WD40,Mcl1_mid,WD40
CMS3_k127_275392_2	716544.wcw_1707	4.925e-34	135.0	COG0334@1|root,COG0334@2|Bacteria,2JFWZ@204428|Chlamydiae	204428|Chlamydiae	C	Belongs to the Glu Leu Phe Val dehydrogenases family	ldh	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_275392_0	314230.DSM3645_30206	3.301e-301	948.0	COG0550@1|root,COG0550@2|Bacteria,2IY53@203682|Planctomycetes	203682|Planctomycetes	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
CMS3_k127_275392_1	1121441.AUCX01000019_gene376	3.134e-37	155.0	COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WPR9@28221|Deltaproteobacteria,2M7TV@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM Metal-dependent hydrolase HDOD	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
CMS3_k127_275392_3	1121861.KB899942_gene3833	2.757e-26	118.0	COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,2TR88@28211|Alphaproteobacteria,2JRK0@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
CMS3_k127_2755483_0	1142394.PSMK_25030	1.784e-207	662.0	COG0348@1|root,COG0492@1|root,COG0348@2|Bacteria,COG0492@2|Bacteria,2J1NR@203682|Planctomycetes	203682|Planctomycetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
CMS3_k127_2755483_2	1123242.JH636438_gene5706	6.475e-07	62.0	COG4886@1|root,COG4886@2|Bacteria,2J0HP@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1570)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1570
CMS3_k127_2755483_1	1161401.ASJA01000013_gene713	1.433e-126	425.0	COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,2TW3I@28211|Alphaproteobacteria,43WXI@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
CMS3_k127_2763408_4	483219.LILAB_05490	6.093e-50	186.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,2YVSU@29|Myxococcales	28221|Deltaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS3_k127_2763408_1	575540.Isop_2730	2.535e-200	636.0	COG2719@1|root,COG2719@2|Bacteria,2IXSH@203682|Planctomycetes	203682|Planctomycetes	S	PFAM SpoVR like protein	-	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
CMS3_k127_2763408_2	765420.OSCT_3035	7.151e-154	493.0	COG2718@1|root,COG2718@2|Bacteria,2G6DB@200795|Chloroflexi,375C8@32061|Chloroflexia	32061|Chloroflexia	S	Belongs to the UPF0229 family	-	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
CMS3_k127_2763408_0	1128421.JAGA01000002_gene90	6.278e-308	956.0	COG2766@1|root,COG2766@2|Bacteria	2|Bacteria	T	protein kinase activity	prkA	GO:0003674,GO:0003824,GO:0004672,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0042594,GO:0043170,GO:0043412,GO:0043562,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0140096,GO:1901564	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
CMS3_k127_2763408_3	1267535.KB906767_gene4620	6.723e-53	200.0	COG2234@1|root,COG2234@2|Bacteria,3Y406@57723|Acidobacteria,2JIRZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS3_k127_2763408_5	1382359.JIAL01000001_gene1834	1.533e-22	113.0	COG2234@1|root,COG2234@2|Bacteria,3Y406@57723|Acidobacteria,2JIRZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS3_k127_2764802_5	497964.CfE428DRAFT_1903	7.673e-13	76.0	COG1104@1|root,COG1104@2|Bacteria,46TNH@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS3_k127_2764802_3	880073.Calab_1356	4.366e-20	103.0	COG1305@1|root,COG1305@2|Bacteria,2NQ2D@2323|unclassified Bacteria	2|Bacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	TIG,Transglut_core
CMS3_k127_2764802_0	234267.Acid_2901	3.346e-67	241.0	COG1975@1|root,COG1975@2|Bacteria,3Y54Y@57723|Acidobacteria	57723|Acidobacteria	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
CMS3_k127_2764802_2	1499967.BAYZ01000041_gene2389	8.576e-30	131.0	COG0204@1|root,COG0204@2|Bacteria,2NPW3@2323|unclassified Bacteria	2|Bacteria	I	Phosphate acyltransferases	cmk	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS3_k127_2764802_6	485913.Krac_2842	1.094e-10	70.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_2764802_1	118166.JH976537_gene2193	5.165e-30	128.0	COG1216@1|root,COG1216@2|Bacteria,1G0X3@1117|Cyanobacteria,1HHXX@1150|Oscillatoriales	1117|Cyanobacteria	S	Glycosyl transferase family 2	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064,Glycos_transf_2
CMS3_k127_2764802_4	1502851.FG93_05230	2.973e-14	83.0	COG3848@1|root,COG3848@2|Bacteria,1R7DS@1224|Proteobacteria,2U3SK@28211|Alphaproteobacteria,3JSC8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Pyruvate phosphate dikinase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2768802_1	103690.17131213	1.213e-70	248.0	COG1335@1|root,COG1335@2|Bacteria,1GKF5@1117|Cyanobacteria,1HQJV@1161|Nostocales	1117|Cyanobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS3_k127_2768802_0	1232437.KL661981_gene3735	4.365e-109	377.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2MIVE@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF_2,HTH_8,PAS,PAS_3,PAS_4,PAS_8,Response_reg,Sigma54_activat
CMS3_k127_2768802_2	215803.DB30_7899	5.62e-16	84.0	2DN1Z@1|root,32V20@2|Bacteria,1Q8W3@1224|Proteobacteria,43E1M@68525|delta/epsilon subdivisions,2WZFP@28221|Deltaproteobacteria,2Z21B@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_277572_0	44060.JODL01000017_gene4213	9.603e-165	544.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the citrate synthase family	gltA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
CMS3_k127_2781422_1	272123.Anacy_0054	1.03e-132	430.0	COG0196@1|root,COG3172@1|root,COG0196@2|Bacteria,COG3172@2|Bacteria,1G79P@1117|Cyanobacteria,1HPNK@1161|Nostocales	1117|Cyanobacteria	H	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_28
CMS3_k127_2781422_0	1535422.ND16A_1363	3.257e-285	890.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,2Q6Y5@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
CMS3_k127_2783609_0	502025.Hoch_0164	1.537e-58	228.0	COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria,1Q385@1224|Proteobacteria,433YW@68525|delta/epsilon subdivisions,2X44A@28221|Deltaproteobacteria,2YY7W@29|Myxococcales	28221|Deltaproteobacteria	E	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
CMS3_k127_2783705_2	1210884.HG799471_gene14622	1.186e-05	58.0	COG1595@1|root,COG4932@1|root,COG1595@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K03088,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko03021	-	-	-	CarboxypepD_reg,Sigma70_r2,Sigma70_r4_2,WD40
CMS3_k127_2783705_1	1267533.KB906740_gene137	1.683e-34	143.0	29Y1S@1|root,30JUQ@2|Bacteria,3Y90C@57723|Acidobacteria,2JNWN@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2783705_0	501479.ACNW01000060_gene2594	5.583e-63	223.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
CMS3_k127_2783899_1	679926.Mpet_1165	0.0001616	55.0	COG1413@1|root,COG5635@1|root,arCOG02967@2157|Archaea,arCOG02971@2157|Archaea	2157|Archaea	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS3_k127_2783899_0	379066.GAU_1166	3.643e-114	388.0	COG2204@1|root,COG2204@2|Bacteria,1ZT50@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_2784360_1	1123242.JH636435_gene1976	2.01e-40	171.0	COG2373@1|root,COG4219@1|root,COG2373@2|Bacteria,COG4219@2|Bacteria,2J096@203682|Planctomycetes	203682|Planctomycetes	KT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Peptidase_M56
CMS3_k127_2784360_2	886293.Sinac_1382	4.659e-31	126.0	COG3682@1|root,COG3682@2|Bacteria,2J3MT@203682|Planctomycetes	203682|Planctomycetes	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS3_k127_2784360_0	344747.PM8797T_06527	1.076e-159	518.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,2IXGT@203682|Planctomycetes	203682|Planctomycetes	C	heme-binding domain, Pirellula Verrucomicrobium type	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,DUF1080
CMS3_k127_2786815_0	269799.Gmet_1965	7.249e-48	186.0	COG3868@1|root,COG3868@2|Bacteria,1NXBJ@1224|Proteobacteria,430FT@68525|delta/epsilon subdivisions,2WVXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2786815_3	575586.HMPREF0016_02270	9.577e-10	70.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,3NM2T@468|Moraxellaceae	1236|Gammaproteobacteria	O	Peptidylprolyl isomerase	ppiD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
CMS3_k127_2786815_2	1123400.KB904788_gene199	4.142e-29	131.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M50
CMS3_k127_2786815_1	765910.MARPU_11690	2.202e-32	135.0	COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,1S77V@1236|Gammaproteobacteria,1WYAI@135613|Chromatiales	135613|Chromatiales	S	PFAM Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CYTH
CMS3_k127_279030_1	497964.CfE428DRAFT_5027	7.678e-23	100.0	COG1520@1|root,COG1520@2|Bacteria,46U9S@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_279030_0	926549.KI421517_gene677	4.997e-55	212.0	COG2133@1|root,COG2133@2|Bacteria,4PKJE@976|Bacteroidetes,47NE6@768503|Cytophagia	976|Bacteroidetes	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS3_k127_279030_2	313628.LNTAR_23744	8.74e-10	71.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	PmoA,ThuA,VCBS
CMS3_k127_2797389_0	1267534.KB906758_gene2417	4.777e-28	125.0	COG4122@1|root,COG4122@2|Bacteria,3Y33U@57723|Acidobacteria,2JIM9@204432|Acidobacteriia	204432|Acidobacteriia	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2799714_2	1210884.HG799466_gene12905	2.856e-05	46.0	COG1520@1|root,COG1520@2|Bacteria,2IX2Z@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_2799714_0	1121012.AUKX01000007_gene221	1.452e-270	844.0	COG2936@1|root,COG2936@2|Bacteria,4NHGT@976|Bacteroidetes,1HYGE@117743|Flavobacteriia,23GR0@178469|Arenibacter	976|Bacteroidetes	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	3.4.14.11	ko:K01281	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PepX_C,Peptidase_S15
CMS3_k127_2799714_1	640511.BC1002_1278	5.443e-81	306.0	COG1262@1|root,COG2319@1|root,COG1262@2|Bacteria,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,2VI8Q@28216|Betaproteobacteria,1K773@119060|Burkholderiaceae	28216|Betaproteobacteria	S	WD40 repeats	-	-	-	ko:K20332	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	NACHT,Pentapeptide,TIR_2,WD40
CMS3_k127_2800305_1	414684.RC1_0823	3.343e-15	89.0	COG1216@1|root,COG1216@2|Bacteria,1MYS1@1224|Proteobacteria,2V83Y@28211|Alphaproteobacteria,2JX8H@204441|Rhodospirillales	204441|Rhodospirillales	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_2800305_0	344747.PM8797T_11571	8.989e-112	379.0	COG0457@1|root,COG1225@1|root,COG0457@2|Bacteria,COG1225@2|Bacteria,2IXTF@203682|Planctomycetes	203682|Planctomycetes	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_280336_0	278963.ATWD01000001_gene2778	3.199e-09	69.0	COG1807@1|root,COG1807@2|Bacteria,3Y46U@57723|Acidobacteria,2JIQH@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_2807729_0	234267.Acid_2163	2.337e-113	371.0	COG1215@1|root,COG1215@2|Bacteria,3Y74D@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_2807729_1	234267.Acid_2160	1.86e-52	195.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_280981_0	290397.Adeh_0078	4.011e-44	167.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	290397.Adeh_0078|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_280981_1	756272.Plabr_2435	5.795e-33	149.0	COG1657@1|root,COG1657@2|Bacteria,2IXVT@203682|Planctomycetes	203682|Planctomycetes	I	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159,Prenyltrans
CMS3_k127_2817646_0	886293.Sinac_0955	3.283e-214	674.0	COG4102@1|root,COG4102@2|Bacteria,2IXAC@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_2817646_1	1210884.HG799478_gene15491	4.389e-05	46.0	COG2010@1|root,COG2010@2|Bacteria,2IWY5@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
CMS3_k127_2837291_0	1123255.JHYS01000016_gene1091	8.413e-33	143.0	COG2340@1|root,COG3055@1|root,COG4447@1|root,COG2340@2|Bacteria,COG3055@2|Bacteria,COG4447@2|Bacteria,1R14N@1224|Proteobacteria,2WHZ9@28216|Betaproteobacteria,4AIB3@80864|Comamonadaceae	28216|Betaproteobacteria	S	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2838004_1	1487953.JMKF01000045_gene2892	7.411e-09	68.0	COG1413@1|root,COG5635@1|root,COG1413@2|Bacteria,COG5635@2|Bacteria,1G233@1117|Cyanobacteria,1H7RE@1150|Oscillatoriales	1117|Cyanobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Metallophos,NACHT,Trypsin_2
CMS3_k127_2838004_0	234267.Acid_6078	1.939e-14	88.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PD40,SdrD_B
CMS3_k127_2839380_4	1192034.CAP_1588	1.069e-13	71.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,42N99@68525|delta/epsilon subdivisions,2WJY8@28221|Deltaproteobacteria,2YTVB@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
CMS3_k127_2839380_2	483219.LILAB_07215	1.878e-24	112.0	COG1225@1|root,COG1225@2|Bacteria,1RD2X@1224|Proteobacteria,430VE@68525|delta/epsilon subdivisions,2WVX8@28221|Deltaproteobacteria,2YVEC@29|Myxococcales	28221|Deltaproteobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
CMS3_k127_2839380_5	396588.Tgr7_0371	4.287e-07	56.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,1SASG@1236|Gammaproteobacteria,1WYFK@135613|Chromatiales	135613|Chromatiales	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
CMS3_k127_2839380_1	324057.Pjdr2_2682	1.255e-64	228.0	COG0120@1|root,COG0120@2|Bacteria,1V1DB@1239|Firmicutes,4HFQ7@91061|Bacilli,26QCU@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
CMS3_k127_2839380_3	667014.Thein_0354	6.988e-14	75.0	COG1918@1|root,COG1918@2|Bacteria,2GI20@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	FeoA	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
CMS3_k127_2839380_0	1408452.JAGZ01000003_gene5107	2.775e-181	589.0	COG0370@1|root,COG0370@2|Bacteria,2GTV2@201174|Actinobacteria,235FD@1762|Mycobacteriaceae	201174|Actinobacteria	P	Ferrous iron transport protein B C terminus	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoA,FeoB_C,FeoB_N,Gate
CMS3_k127_2842247_1	886293.Sinac_0923	2.011e-101	351.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,2IXPU@203682|Planctomycetes	203682|Planctomycetes	C	heme-binding domain, Pirellula Verrucomicrobium type	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
CMS3_k127_2842247_2	502025.Hoch_2065	8.253e-64	233.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,42P0U@68525|delta/epsilon subdivisions,2WJC6@28221|Deltaproteobacteria,2YVSY@29|Myxococcales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CMS3_k127_2842247_0	467661.RKLH11_3573	3.135e-120	398.0	COG5441@1|root,COG5441@2|Bacteria,1MX45@1224|Proteobacteria,2TUHA@28211|Alphaproteobacteria,3ZGA3@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	S	Uncharacterised protein family (UPF0261)	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,UPF0261
CMS3_k127_2842247_3	314256.OG2516_16479	4.104e-57	202.0	COG5564@1|root,COG5564@2|Bacteria,1MXTY@1224|Proteobacteria,2TSJ2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	TIM-barrel enzyme, possibly a dioxygenase	MA20_13935	-	-	-	-	-	-	-	-	-	-	-	PEP_hydrolase
CMS3_k127_2847355_1	1280390.CBQR020000133_gene3307	2.609e-09	59.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli,26YYQ@186822|Paenibacillaceae	91061|Bacilli	K	Cold-shock protein	cspB	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CMS3_k127_2847355_0	194439.CT0108	6.183e-49	203.0	COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,1FESR@1090|Chlorobi	1090|Chlorobi	KT	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HTH_8,Sigma54_activat
CMS3_k127_2852287_3	1397528.Q671_03525	1.281e-73	262.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1XIWE@135619|Oceanospirillales	135619|Oceanospirillales	E	PFAM Cys Met metabolism	-	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
CMS3_k127_2852287_0	1519464.HY22_10360	1.691e-160	523.0	COG0154@1|root,COG0154@2|Bacteria,1FDMC@1090|Chlorobi	2|Bacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS3_k127_2852287_2	1248916.ANFY01000007_gene2507	1.715e-74	259.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,2K1HB@204457|Sphingomonadales	204457|Sphingomonadales	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
CMS3_k127_2852287_5	502025.Hoch_6764	4.939e-46	179.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,42RIC@68525|delta/epsilon subdivisions,2WNRX@28221|Deltaproteobacteria,2Z30D@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
CMS3_k127_2852287_1	448385.sce5399	6.27e-83	296.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,42MSB@68525|delta/epsilon subdivisions,2WJI6@28221|Deltaproteobacteria,2YWRH@29|Myxococcales	28221|Deltaproteobacteria	L	OB-fold nucleic acid binding domain	-	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
CMS3_k127_2852287_6	448385.sce5400	1.708e-07	56.0	COG1722@1|root,COG1722@2|Bacteria,1PY7Z@1224|Proteobacteria,43E1X@68525|delta/epsilon subdivisions,2WZGE@28221|Deltaproteobacteria,2Z23D@29|Myxococcales	28221|Deltaproteobacteria	L	Exonuclease VII small subunit	-	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
CMS3_k127_2852287_4	1499967.BAYZ01000194_gene3127	7.361e-47	177.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
CMS3_k127_2854570_1	404589.Anae109_4276	8.098e-80	280.0	COG3213@1|root,COG3213@2|Bacteria,1Q61U@1224|Proteobacteria,4328M@68525|delta/epsilon subdivisions,2WXFV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	NnrS protein	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
CMS3_k127_2854570_2	984262.SGRA_3854	4.852e-54	194.0	COG4894@1|root,COG4894@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K21429	-	-	-	-	ko00000,ko01002	-	-	-	LOR
CMS3_k127_2854570_3	497964.CfE428DRAFT_2304	1.085e-53	207.0	COG2755@1|root,COG2755@2|Bacteria,46T1W@74201|Verrucomicrobia	74201|Verrucomicrobia	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS3_k127_2854570_4	903818.KI912268_gene1598	1.588e-37	149.0	COG0694@1|root,COG0694@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	nifU	-	-	-	-	-	-	-	-	-	-	-	NifU
CMS3_k127_2854570_0	886293.Sinac_6485	2.829e-306	963.0	COG0613@1|root,COG0613@2|Bacteria,2IY27@203682|Planctomycetes	203682|Planctomycetes	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2854570_5	1380390.JIAT01000009_gene444	7.785e-06	58.0	COG1595@1|root,COG1595@2|Bacteria,2I9C1@201174|Actinobacteria,4CQXP@84995|Rubrobacteria	84995|Rubrobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_2858839_2	215803.DB30_6067	4.077e-07	63.0	COG2319@1|root,COG4995@1|root,COG2319@2|Bacteria,COG4995@2|Bacteria,1MWJA@1224|Proteobacteria,42P8D@68525|delta/epsilon subdivisions,2WMH1@28221|Deltaproteobacteria,2Z33N@29|Myxococcales	28221|Deltaproteobacteria	T	SMART serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,CHAT,Pkinase,WD40
CMS3_k127_2858839_1	886293.Sinac_6207	1.164e-36	154.0	COG2234@1|root,COG2234@2|Bacteria,2IZ1R@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS3_k127_2858839_0	1229780.BN381_130026	0.0	1049.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,3UWEV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iNJ661.Rv3436c	GATase_6,SIS
CMS3_k127_2858857_4	1254432.SCE1572_49835	5.436e-12	67.0	COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2YX5D@29|Myxococcales	28221|Deltaproteobacteria	E	Aconitase C-terminal domain	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
CMS3_k127_2858857_0	1382306.JNIM01000001_gene1598	3.221e-130	429.0	COG0183@1|root,COG0183@2|Bacteria,2G5YW@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_2858857_1	4558.Sb09g003920.1	5.832e-99	332.0	COG0190@1|root,KOG0089@2759|Eukaryota,37K6Z@33090|Viridiplantae,3GCGD@35493|Streptophyta,3KS3D@4447|Liliopsida,3I3PT@38820|Poales	35493|Streptophyta	H	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	-	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009507,GO:0009536,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019219,GO:0019222,GO:0019238,GO:0019752,GO:0031323,GO:0034641,GO:0042558,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0044030,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046653,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0051186,GO:0055114,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
CMS3_k127_2858857_2	1121920.AUAU01000023_gene2419	1.349e-66	235.0	COG2086@1|root,COG2086@2|Bacteria,3Y2PD@57723|Acidobacteria	57723|Acidobacteria	C	Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
CMS3_k127_2858857_3	1334046.AYTB01000008_gene2802	4.461e-34	139.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,4HAE2@91061|Bacilli,26DPF@186818|Planococcaceae	91061|Bacilli	C	Electron transfer flavoprotein alpha subunit	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
CMS3_k127_2863614_1	756272.Plabr_3920	4.377e-105	372.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG2755@1|root,COG3794@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,COG2755@2|Bacteria,COG3794@2|Bacteria,2IX6X@203682|Planctomycetes	203682|Planctomycetes	C	Membrane-bound dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cytochrom_C,Lipase_GDSL_2
CMS3_k127_2863614_0	243090.RB605	3.548e-158	514.0	COG3119@1|root,COG3119@2|Bacteria,2J1ZQ@203682|Planctomycetes	203682|Planctomycetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_2863614_2	1177179.A11A3_04049	5.932e-49	179.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,1XJUJ@135619|Oceanospirillales	135619|Oceanospirillales	O	Peptidyl-prolyl cis-trans isomerase	slyD	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
CMS3_k127_2865726_0	1232410.KI421428_gene1119	7.129e-121	404.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,43UDA@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM peptidase S1 and S6, chymotrypsin Hap	degP	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_2865726_2	1121441.AUCX01000013_gene1920	1.255e-63	231.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2WIYU@28221|Deltaproteobacteria,2M9CJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Ion transport 2 domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
CMS3_k127_2865726_1	1283300.ATXB01000001_gene2088	1.032e-107	387.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1XE6E@135618|Methylococcales	135618|Methylococcales	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
CMS3_k127_287694_1	1265503.KB905163_gene2277	2.498e-27	130.0	COG3420@1|root,COG5306@1|root,COG3420@2|Bacteria,COG5306@2|Bacteria,1NGRY@1224|Proteobacteria,1T22S@1236|Gammaproteobacteria,2Q81Z@267889|Colwelliaceae	1236|Gammaproteobacteria	P	Pentaxin family	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	CUB,Laminin_G_3
CMS3_k127_287694_3	700598.Niako_5872	4.741e-13	83.0	COG3533@1|root,COG4733@1|root,COG3533@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.14,3.2.1.99	ko:K01183,ko:K06113	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18,GH43	-	Big_2,Cadherin-like,Glyco_hydro_127,Laminin_G_3,SLH,fn3
CMS3_k127_287694_0	243090.RB154	4.904e-42	179.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Cadherin,DUF11,DUF4347,DUF5122,He_PIG,Laminin_G_3,SBBP
CMS3_k127_287694_2	1123242.JH636434_gene4731	9.963e-22	100.0	COG1131@1|root,COG1131@2|Bacteria,2IZVY@203682|Planctomycetes	203682|Planctomycetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_2879601_1	706587.Desti_4506	4.335e-216	694.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MWZC@1224|Proteobacteria,42QPM@68525|delta/epsilon subdivisions,2WMRG@28221|Deltaproteobacteria,2MQER@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH_N,ECH_1
CMS3_k127_2879601_5	314230.DSM3645_18761	2.285e-17	82.0	COG0267@1|root,COG0267@2|Bacteria,2J0Q2@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
CMS3_k127_2879601_6	1121382.JQKG01000007_gene3623	1.904e-08	68.0	2CK9P@1|root,33K0M@2|Bacteria,1WM0K@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2879601_3	1123059.KB823014_gene225	1.064e-59	218.0	COG0331@1|root,COG0331@2|Bacteria,1MW5Y@1224|Proteobacteria,2TT74@28211|Alphaproteobacteria,43ZCT@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Acyl-carrier-protein s-malonyltransferase	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
CMS3_k127_2879601_0	1121013.P873_01825	3.609e-231	737.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1P31Y@1224|Proteobacteria,1RQNS@1236|Gammaproteobacteria,1X4XU@135614|Xanthomonadales	135614|Xanthomonadales	C	MFS transporter	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
CMS3_k127_2879601_4	1125863.JAFN01000001_gene1790	9.549e-50	184.0	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,42UR1@68525|delta/epsilon subdivisions,2WPQ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS3_k127_2879601_2	518766.Rmar_0603	2.995e-65	238.0	COG4232@1|root,COG4232@2|Bacteria,4NEW6@976|Bacteroidetes,1FJJN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	CO	Disulphide bond corrector protein DsbC	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
CMS3_k127_2879867_2	1123065.ATWL01000004_gene2785	3.442e-10	72.0	COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria	201174|Actinobacteria	T	(FHA) domain	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
CMS3_k127_2879867_0	886293.Sinac_2883	7.541e-50	194.0	COG1762@1|root,COG3311@1|root,COG1762@2|Bacteria,COG3311@2|Bacteria,2IZFY@203682|Planctomycetes	203682|Planctomycetes	G	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
CMS3_k127_2879867_1	530564.Psta_1008	4.149e-20	92.0	COG1309@1|root,COG1309@2|Bacteria,2IZ6X@203682|Planctomycetes	203682|Planctomycetes	K	Bacterial regulatory proteins, tetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_28841_0	344747.PM8797T_30566	7.609e-95	315.0	COG1012@1|root,COG1012@2|Bacteria,2IXUV@203682|Planctomycetes	203682|Planctomycetes	C	COG1012 NAD-dependent aldehyde	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
CMS3_k127_2897114_0	243231.GSU2744	1.005e-119	399.0	COG0477@1|root,COG0477@2|Bacteria,1QWSX@1224|Proteobacteria,43C55@68525|delta/epsilon subdivisions,2X7FI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_2903394_4	313606.M23134_02037	2.665e-45	178.0	2925F@1|root,2ZPQC@2|Bacteria,4P3UR@976|Bacteroidetes	976|Bacteroidetes	S	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
CMS3_k127_2903394_0	1121403.AUCV01000007_gene1233	4.101e-164	532.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,42NHS@68525|delta/epsilon subdivisions,2WJHI@28221|Deltaproteobacteria,2MIF6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
CMS3_k127_2903394_5	382464.ABSI01000014_gene1434	1.823e-26	113.0	COG3288@1|root,COG3288@2|Bacteria,46T7S@74201|Verrucomicrobia	74201|Verrucomicrobia	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
CMS3_k127_2903394_1	247633.GP2143_08674	5.072e-145	469.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1J4FV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NAD(P) transhydrogenase, alpha subunit	pntA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	iEcE24377_1341.EcE24377A_1810	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
CMS3_k127_2903394_3	1131813.AQVT01000001_gene2403	3.695e-49	187.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,2TRRN@28211|Alphaproteobacteria,1JURW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
CMS3_k127_2903394_2	215803.DB30_3661	1.946e-55	199.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,42N8C@68525|delta/epsilon subdivisions,2WM3N@28221|Deltaproteobacteria,2YUFY@29|Myxococcales	28221|Deltaproteobacteria	K	AlkA N-terminal domain	-	-	3.2.2.21	ko:K13529,ko:K13530	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
CMS3_k127_2904199_0	290397.Adeh_3892	1.375e-288	914.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,42M9A@68525|delta/epsilon subdivisions,2WJ3Y@28221|Deltaproteobacteria,2YUEP@29|Myxococcales	28221|Deltaproteobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
CMS3_k127_2919320_1	405948.SACE_0461	1.927e-87	299.0	COG1877@1|root,COG3387@1|root,COG1877@2|Bacteria,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4DX52@85010|Pseudonocardiales	201174|Actinobacteria	G	Glycosyl hydrolases family 15	otsB	-	3.1.3.12,3.2.1.3	ko:K01087,ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R02778,R06199	RC00017	ko00000,ko00001,ko01000	-	GH15	-	Glyco_hydro_15,Trehalose_PPase
CMS3_k127_2919320_0	1380347.JNII01000011_gene813	2.442e-155	506.0	COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4ESJT@85013|Frankiales	201174|Actinobacteria	G	PFAM Glycosyl transferase, family 20	otsA	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
CMS3_k127_2919320_2	589865.DaAHT2_2138	3.383e-61	236.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2MIBK@213118|Desulfobacterales	68525|delta/epsilon subdivisions	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
CMS3_k127_2919320_3	883156.HMPREF9282_01514	3.817e-10	74.0	COG2911@1|root,COG2911@2|Bacteria,1TQZZ@1239|Firmicutes,4H2F1@909932|Negativicutes	909932|Negativicutes	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	AsmA_2,TamB
CMS3_k127_293152_0	344747.PM8797T_05840	9.345e-120	394.0	COG3119@1|root,COG3119@2|Bacteria,2IXR4@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.12	ko:K01135	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00076,M00077	R07823	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
CMS3_k127_293152_2	886293.Sinac_0388	2.497e-88	306.0	COG1621@1|root,COG1621@2|Bacteria,2IZ2Q@203682|Planctomycetes	203682|Planctomycetes	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_293152_1	1304880.JAGB01000002_gene1607	2.431e-116	389.0	COG3119@1|root,COG3119@2|Bacteria,1V6NF@1239|Firmicutes,24MBN@186801|Clostridia	186801|Clostridia	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_293152_4	1250278.JQNQ01000001_gene386	3.487e-09	59.0	COG4276@1|root,COG4276@2|Bacteria,4NQJG@976|Bacteroidetes,1I17G@117743|Flavobacteriia	976|Bacteroidetes	S	SRPBCC domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
CMS3_k127_2931631_0	314230.DSM3645_19478	4.95e-126	414.0	COG3119@1|root,COG3119@2|Bacteria,2IX0S@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS3_k127_293167_5	1415779.JOMH01000001_gene114	4.673e-22	96.0	COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,1X97Y@135614|Xanthomonadales	135614|Xanthomonadales	C	Rnf-Nqr subunit, membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Rnf-Nqr
CMS3_k127_293167_1	754477.Q7C_1709	1.038e-95	316.0	COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,1RMWV@1236|Gammaproteobacteria,4608S@72273|Thiotrichales	72273|Thiotrichales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrE	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
CMS3_k127_293167_0	344747.PM8797T_12026	5.136e-196	617.0	COG2871@1|root,COG2871@2|Bacteria,2IXJE@203682|Planctomycetes	203682|Planctomycetes	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway	nqrF	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
CMS3_k127_293167_2	1121441.AUCX01000006_gene991	1.65e-89	306.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,42MZQ@68525|delta/epsilon subdivisions,2WJNE@28221|Deltaproteobacteria,2M8MR@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
CMS3_k127_293167_6	1415778.JQMM01000001_gene1911	1.053e-05	49.0	COG2991@1|root,COG2991@2|Bacteria,1Q5RE@1224|Proteobacteria,1RTZB@1236|Gammaproteobacteria,1J7D6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K05952	-	-	-	-	ko00000	-	-	-	NqrM
CMS3_k127_293167_4	314230.DSM3645_21719	9.38e-29	123.0	COG0517@1|root,COG0517@2|Bacteria,2J04X@203682|Planctomycetes	203682|Planctomycetes	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS3_k127_293167_3	1035308.AQYY01000001_gene1950	1.387e-29	125.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_2933802_1	404589.Anae109_2645	2.956e-94	334.0	COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,4397N@68525|delta/epsilon subdivisions,2X4EI@28221|Deltaproteobacteria,2YYVA@29|Myxococcales	28221|Deltaproteobacteria	C	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
CMS3_k127_2933802_0	880073.Calab_3330	2.389e-100	356.0	COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,2NS2I@2323|unclassified Bacteria	2|Bacteria	O	Pyridine nucleotide-disulphide oxidoreductase	trxB_2	-	1.18.1.2,1.19.1.1,1.8.1.9	ko:K00384,ko:K21567	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,Pyr_redox_3
CMS3_k127_2933802_3	794846.AJQU01000062_gene2548	6.307e-55	209.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2TRDA@28211|Alphaproteobacteria,4B8BD@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
CMS3_k127_2933802_6	1123072.AUDH01000020_gene2069	3.284e-35	153.0	COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2TSU3@28211|Alphaproteobacteria,2JPIW@204441|Rhodospirillales	204441|Rhodospirillales	S	Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
CMS3_k127_2933802_2	649638.Trad_2429	1.26e-67	241.0	COG0530@1|root,COG0530@2|Bacteria,1WJ9P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	COG0530 Ca2 Na antiporter	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS3_k127_2933802_9	1540257.JQMW01000009_gene2879	0.0002387	52.0	COG0494@1|root,COG0494@2|Bacteria,1VFQP@1239|Firmicutes,24S7D@186801|Clostridia	186801|Clostridia	L	NUDIX domain	-	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
CMS3_k127_2933802_4	1378168.N510_01615	3.424e-51	200.0	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes	1239|Firmicutes	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
CMS3_k127_2933802_8	215803.DB30_6469	9.362e-05	56.0	COG1572@1|root,COG1572@2|Bacteria,1Q29U@1224|Proteobacteria,437WP@68525|delta/epsilon subdivisions,2WYQ0@28221|Deltaproteobacteria,2YUQ2@29|Myxococcales	28221|Deltaproteobacteria	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
CMS3_k127_2933802_5	67373.JOBF01000026_gene6955	1.188e-43	183.0	COG2304@1|root,COG2304@2|Bacteria,2GKPD@201174|Actinobacteria	201174|Actinobacteria	E	IgA Peptidase M64	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M64
CMS3_k127_2933802_7	67315.JOBD01000036_gene4456	2.046e-05	57.0	COG1413@1|root,COG1413@2|Bacteria,2IGUV@201174|Actinobacteria	201174|Actinobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS3_k127_2941220_2	1123072.AUDH01000006_gene3243	5.302e-25	117.0	COG2230@1|root,COG2230@2|Bacteria,1R1FZ@1224|Proteobacteria,2TZ1A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	CMAS
CMS3_k127_2941220_0	1121904.ARBP01000001_gene5897	1.186e-49	188.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS3_k127_2941220_1	105559.Nwat_1947	5.207e-40	156.0	COG2020@1|root,COG2020@2|Bacteria,1RCWQ@1224|Proteobacteria	1224|Proteobacteria	O	protein-S-isoprenylcysteine methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
CMS3_k127_2941220_3	472759.Nhal_2055	1.907e-21	100.0	COG0558@1|root,COG0558@2|Bacteria,1N1AE@1224|Proteobacteria,1SBCI@1236|Gammaproteobacteria,1X1ZI@135613|Chromatiales	135613|Chromatiales	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
CMS3_k127_2941457_1	1121875.KB907546_gene2204	7.775e-163	523.0	COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1HY2V@117743|Flavobacteriia	976|Bacteroidetes	Q	Imidazolonepropionase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_2941457_2	102125.Xen7305DRAFT_00004000	1.058e-123	408.0	COG3659@1|root,COG3659@2|Bacteria	2|Bacteria	M	wide pore channel activity	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
CMS3_k127_2941457_0	756272.Plabr_1879	2.587e-171	545.0	COG3119@1|root,COG3119@2|Bacteria,2IX9P@203682|Planctomycetes	203682|Planctomycetes	P	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_294514_1	1408254.T458_00475	8.886e-28	129.0	COG2355@1|root,COG2355@2|Bacteria,1TRNQ@1239|Firmicutes,4HEBU@91061|Bacilli,26QKV@186822|Paenibacillaceae	91061|Bacilli	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
CMS3_k127_294514_0	471854.Dfer_3146	1.292e-35	155.0	COG2931@1|root,COG2931@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
CMS3_k127_2947081_6	1227487.C474_11246	5.681e-20	103.0	arCOG02998@1|root,arCOG02998@2157|Archaea,2XX29@28890|Euryarchaeota,23VR4@183963|Halobacteria	183963|Halobacteria	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_2947081_2	1121875.KB907548_gene1476	1.509e-84	289.0	COG5553@1|root,COG5553@2|Bacteria,4NJMB@976|Bacteroidetes,1I0CQ@117743|Flavobacteriia	976|Bacteroidetes	S	Cysteine dioxygenase type I	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2947081_3	1254432.SCE1572_08670	2.287e-74	267.0	COG4826@1|root,COG4826@2|Bacteria,1REGX@1224|Proteobacteria,42T9N@68525|delta/epsilon subdivisions,2WPDB@28221|Deltaproteobacteria,2YV97@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
CMS3_k127_2947081_1	886293.Sinac_2703	2.882e-88	302.0	COG0240@1|root,COG0240@2|Bacteria,2IWWN@203682|Planctomycetes	203682|Planctomycetes	I	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
CMS3_k127_2947081_4	1304888.ATWF01000001_gene692	1.689e-28	122.0	COG0344@1|root,COG0344@2|Bacteria,2GFJ8@200930|Deferribacteres	200930|Deferribacteres	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
CMS3_k127_2947081_0	648996.Theam_0093	3.684e-123	418.0	COG0145@1|root,COG0145@2|Bacteria,2G3PK@200783|Aquificae	200783|Aquificae	EQ	Hydantoinase/oxoprolinase N-terminal region	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
CMS3_k127_2947081_5	880073.Calab_1753	3.749e-28	127.0	COG3437@1|root,COG3437@2|Bacteria,2NP8B@2323|unclassified Bacteria	2|Bacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5,Response_reg
CMS3_k127_2951984_2	321327.CYA_0782	6.11e-19	102.0	COG1305@1|root,COG1305@2|Bacteria,1FZW2@1117|Cyanobacteria,1GZT0@1129|Synechococcus	1117|Cyanobacteria	E	Transglutaminase/protease-like homologues	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
CMS3_k127_2951984_3	979556.MTES_0964	4.669e-15	87.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4FKRH@85023|Microbacteriaceae	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_2951984_1	1347087.CBYO010000001_gene68	6.986e-85	293.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,4HA0T@91061|Bacilli	91061|Bacilli	S	ATPase associated with various cellular activities AAA_3	yeaC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_2951984_0	1123070.KB899255_gene1340	7.946e-142	461.0	COG1502@1|root,COG1502@2|Bacteria,46SV9@74201|Verrucomicrobia,2IV54@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2,PLDc_N
CMS3_k127_2957198_2	105559.Nwat_0320	1.593e-46	176.0	2C6TB@1|root,32RHR@2|Bacteria,1RKX5@1224|Proteobacteria,1SPS0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2957198_1	105559.Nwat_0325	4.103e-111	376.0	COG2159@1|root,COG2159@2|Bacteria,1R73N@1224|Proteobacteria	1224|Proteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
CMS3_k127_2957198_0	1278073.MYSTI_01848	1.684e-146	477.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	sfnR	-	-	ko:K11917	-	-	-	-	ko00000,ko02044,ko03000	-	-	-	HTH_8,Sigma54_activat
CMS3_k127_2957198_4	344747.PM8797T_31208	2.123e-05	56.0	COG1595@1|root,COG1595@2|Bacteria,2J06I@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_2957198_3	1278073.MYSTI_06425	1.087e-41	179.0	COG1075@1|root,COG1361@1|root,COG5492@1|root,COG1075@2|Bacteria,COG1361@2|Bacteria,COG5492@2|Bacteria,1P60C@1224|Proteobacteria,4395U@68525|delta/epsilon subdivisions,2X4CF@28221|Deltaproteobacteria,2YYRC@29|Myxococcales	28221|Deltaproteobacteria	N	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PGAP1
CMS3_k127_2964391_0	391625.PPSIR1_07223	3.962e-133	442.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,42N9T@68525|delta/epsilon subdivisions,2WIMI@28221|Deltaproteobacteria,2Z24K@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS3_k127_2964391_1	1288963.ADIS_0253	1.977e-129	428.0	COG3119@1|root,COG3119@2|Bacteria,4NF1X@976|Bacteroidetes,47MQK@768503|Cytophagia	976|Bacteroidetes	P	Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS3_k127_2964391_3	472759.Nhal_1348	1.659e-89	333.0	COG1858@1|root,COG1858@2|Bacteria,1RC4D@1224|Proteobacteria,1SJKT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2964391_6	926550.CLDAP_36750	6.987e-30	133.0	COG3214@1|root,COG3214@2|Bacteria,2G766@200795|Chloroflexi	200795|Chloroflexi	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
CMS3_k127_2964391_2	1396418.BATQ01000003_gene1354	1.018e-97	336.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS3_k127_2964391_7	1157490.EL26_14130	1.877e-09	69.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4HB0C@91061|Bacilli,278UP@186823|Alicyclobacillaceae	91061|Bacilli	NU	type II secretion system protein E	pilB	-	-	ko:K02243,ko:K02652	-	M00429	-	-	ko00000,ko00002,ko02035,ko02044	3.A.14.1,3.A.15.2	-	-	T2SSE,T2SSE_N
CMS3_k127_2964391_4	1210884.HG799463_gene9442	4.257e-49	197.0	COG1520@1|root,COG1520@2|Bacteria,2IXXG@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS3_k127_2964391_5	714943.Mucpa_0843	3.837e-33	142.0	COG0526@1|root,COG0526@2|Bacteria,4P09G@976|Bacteroidetes,1IVPY@117747|Sphingobacteriia	976|Bacteroidetes	O	Domain of unknown function (DUF4369)	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF4369
CMS3_k127_296779_4	1299327.I546_5559	1.589e-24	105.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_28,HTH_29,HTH_32,LZ_Tnp_IS481
CMS3_k127_296779_1	1299327.I546_5558	5.12e-116	381.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,23B0M@1762|Mycobacteriaceae	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
CMS3_k127_296779_0	1121011.AUCB01000002_gene477	2.864e-124	417.0	COG0673@1|root,COG0673@2|Bacteria,4NKZ2@976|Bacteroidetes,1I00G@117743|Flavobacteriia,23GVT@178469|Arenibacter	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_296779_2	1210884.HG799467_gene13438	4.915e-91	307.0	COG1082@1|root,COG1082@2|Bacteria,2IWW9@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase domain protein TIM barrel	-	-	5.1.3.30,5.1.3.31	ko:K18910	-	-	R10817,R10818	RC03111,RC03283	ko00000,ko01000	-	-	-	AP_endonuc_2
CMS3_k127_296779_3	314230.DSM3645_14945	2.362e-30	123.0	COG0673@1|root,COG0673@2|Bacteria,2IXUF@203682|Planctomycetes	2|Bacteria	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_2974339_0	1123508.JH636441_gene3102	4.807e-11	75.0	COG4099@1|root,COG4099@2|Bacteria,2IZGJ@203682|Planctomycetes	203682|Planctomycetes	M	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,DLH,Peptidase_S9
CMS3_k127_2974339_1	696747.NIES39_O04890	1.778e-05	58.0	COG1413@1|root,COG1413@2|Bacteria,1G511@1117|Cyanobacteria,1HATT@1150|Oscillatoriales	1117|Cyanobacteria	C	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS3_k127_2978198_6	945713.IALB_0020	9.149e-34	133.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	hom	-	1.1.1.3,1.1.1.399,1.1.1.95,1.3.1.12,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04517,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00400,ko00401,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00400,map00401,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00025,M00570	R00220,R00996,R01513,R01728,R01773,R01775	RC00031,RC00087,RC00125,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3
CMS3_k127_2978198_5	1121459.AQXE01000018_gene2110	9.652e-35	139.0	2A42S@1|root,30SMP@2|Bacteria,1RFZA@1224|Proteobacteria,42S6K@68525|delta/epsilon subdivisions,2WNVV@28221|Deltaproteobacteria,2MFDE@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Nickel-containing superoxide dismutase	-	-	1.15.1.1	ko:K00518	-	-	-	-	ko00000,ko01000	-	-	-	Sod_Ni
CMS3_k127_2978198_1	882.DVU_1270	2.752e-77	284.0	COG2805@1|root,COG2805@2|Bacteria,1NEYE@1224|Proteobacteria,43B76@68525|delta/epsilon subdivisions,2X6KM@28221|Deltaproteobacteria,2MH47@213115|Desulfovibrionales	28221|Deltaproteobacteria	NU	Type II/IV secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
CMS3_k127_2978198_8	1463825.JNXC01000045_gene3036	3.479e-22	111.0	COG2040@1|root,COG2040@2|Bacteria,2HSC2@201174|Actinobacteria,4ED7T@85010|Pseudonocardiales	201174|Actinobacteria	E	Homocysteine S-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	S-methyl_trans
CMS3_k127_2978198_10	83406.HDN1F_10010	6.133e-07	61.0	COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS3_k127_2978198_4	446462.Amir_2487	1.258e-39	164.0	COG0515@1|root,COG0515@2|Bacteria,2GNXG@201174|Actinobacteria,4E11Q@85010|Pseudonocardiales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_2978198_7	105425.BBPL01000032_gene4682	2.457e-27	130.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,2NNIR@228398|Streptacidiphilus	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_2978198_3	266117.Rxyl_0848	5.249e-63	224.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CPWA@84995|Rubrobacteria	84995|Rubrobacteria	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_2978198_0	439235.Dalk_1804	1.011e-85	313.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,42NG6@68525|delta/epsilon subdivisions,2WIRU@28221|Deltaproteobacteria,2MK6C@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
CMS3_k127_2978198_2	1118235.CAJH01000044_gene2815	2.817e-63	235.0	COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria,1RZA4@1236|Gammaproteobacteria,1X7KS@135614|Xanthomonadales	135614|Xanthomonadales	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_2978198_9	1384054.N790_01345	1.716e-17	90.0	COG1309@1|root,COG1309@2|Bacteria,1RCI9@1224|Proteobacteria,1SYP1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_2980058_0	644968.DFW101_3733	4.311e-12	79.0	COG4485@1|root,COG4485@2|Bacteria	2|Bacteria	M	Bacterial membrane protein, YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
CMS3_k127_2984013_0	1120936.KB907220_gene2042	2.671e-144	468.0	COG1073@1|root,COG1073@2|Bacteria,2I2SR@201174|Actinobacteria,4ER20@85012|Streptosporangiales	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_2984013_2	649638.Trad_1693	3.037e-18	98.0	COG3342@1|root,COG3342@2|Bacteria,1WIWT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	peptidoglycan binding domain	fimA	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
CMS3_k127_2984013_1	204669.Acid345_1520	7.629e-32	127.0	COG0624@1|root,COG0624@2|Bacteria,3Y2UM@57723|Acidobacteria,2JKEA@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_2987883_1	485918.Cpin_4245	1.351e-09	61.0	COG1262@1|root,COG1262@2|Bacteria,4P18J@976|Bacteroidetes,1IW48@117747|Sphingobacteriia	976|Bacteroidetes	S	Sulfatase-modifying factor enzyme 1	-	-	1.8.3.7	ko:K13444	ko04142,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase
CMS3_k127_2987883_0	314230.DSM3645_09412	5.866e-146	487.0	COG0480@1|root,COG0480@2|Bacteria,2IXUD@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS3_k127_2987883_2	797114.C475_18368	1.866e-05	57.0	COG1520@1|root,arCOG02492@2157|Archaea,2Y7Q0@28890|Euryarchaeota,23SYZ@183963|Halobacteria	183963|Halobacteria	M	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS3_k127_2992705_1	1123242.JH636435_gene2776	1.523e-38	151.0	COG3682@1|root,COG3682@2|Bacteria,2J0N4@203682|Planctomycetes	203682|Planctomycetes	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS3_k127_2992705_2	1123508.JH636440_gene2525	3.861e-25	112.0	29F7N@1|root,3025B@2|Bacteria,2J0ZE@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2992705_0	1210884.HG799462_gene7874	3.556e-180	580.0	COG2268@1|root,COG2268@2|Bacteria,2IYIX@203682|Planctomycetes	203682|Planctomycetes	S	prohibitin homologues	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7
CMS3_k127_2992705_3	575540.Isop_3410	7.667e-18	87.0	COG0227@1|root,COG0227@2|Bacteria,2J0SS@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
CMS3_k127_2992893_2	1123508.JH636439_gene1614	3.667e-40	161.0	COG3828@1|root,COG3828@2|Bacteria,2IXPS@203682|Planctomycetes	203682|Planctomycetes	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
CMS3_k127_2992893_0	457429.ABJI02000018_gene1102	3.486e-59	217.0	COG2133@1|root,COG2133@2|Bacteria,2GRVP@201174|Actinobacteria	201174|Actinobacteria	G	PA14	-	-	-	-	-	-	-	-	-	-	-	-	CBM_35,DUF1080,PA14
CMS3_k127_2992893_1	1227453.C444_06281	6.045e-49	181.0	COG0225@1|root,arCOG02816@2157|Archaea,2XWW5@28890|Euryarchaeota,23V7B@183963|Halobacteria	183963|Halobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA2	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
CMS3_k127_2992893_3	65071.PYU1_T011450	7.479e-07	63.0	28K2B@1|root,2QSGV@2759|Eukaryota,1MBI3@121069|Pythiales	121069|Pythiales	T	Carbohydrate-binding protein. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
CMS3_k127_300447_0	247490.KSU1_D0284	9.051e-48	186.0	COG0105@1|root,COG0105@2|Bacteria,2IZQ6@203682|Planctomycetes	203682|Planctomycetes	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
CMS3_k127_300447_1	1225785.CM001983_gene3211	7.952e-21	100.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1RWZI@1236|Gammaproteobacteria,2JEM8@204037|Dickeya	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS3_k127_3009681_0	314230.DSM3645_08196	2.597e-115	415.0	COG0457@1|root,COG1729@1|root,COG2373@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,COG2373@2|Bacteria,2IWRT@203682|Planctomycetes	203682|Planctomycetes	S	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,TPR_16
CMS3_k127_3011884_2	511.JT27_02860	2.57e-19	93.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2VIZ6@28216|Betaproteobacteria,3T3KD@506|Alcaligenaceae	28216|Betaproteobacteria	G	Phosphoglycolate phosphatase	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS3_k127_3011884_3	1123059.KB823012_gene2167	4.661e-17	94.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria,43WSG@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
CMS3_k127_3011884_0	1540221.JQNI01000002_gene2710	2.862e-37	148.0	COG0125@1|root,COG0125@2|Bacteria,1WK3U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
CMS3_k127_3011884_1	1142394.PSMK_07410	2.131e-33	146.0	COG0470@1|root,COG0470@2|Bacteria,2IZ3J@203682|Planctomycetes	203682|Planctomycetes	L	COG2812 DNA polymerase III, gamma tau subunits	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
CMS3_k127_301295_1	760192.Halhy_1128	9.014e-80	300.0	COG3209@1|root,COG3209@2|Bacteria,4NFUE@976|Bacteroidetes,1INSI@117747|Sphingobacteriia	976|Bacteroidetes	M	COG3209 Rhs family protein	rhsA	-	-	-	-	-	-	-	-	-	-	-	RHS,RHS_repeat
CMS3_k127_301295_0	1242864.D187_006651	1.436e-153	501.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2WIXQ@28221|Deltaproteobacteria,2YV8R@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the GPI family	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
CMS3_k127_301295_3	673860.AciM339_1223	6.658e-56	220.0	COG0847@1|root,arCOG06460@2157|Archaea,2XZQV@28890|Euryarchaeota	28890|Euryarchaeota	L	P-loop Domain of unknown function (DUF2791)	-	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	DUF2791
CMS3_k127_301295_4	673860.AciM339_1222	6.336e-18	99.0	COG0847@1|root,arCOG06460@2157|Archaea	2157|Archaea	L	P-loop Domain of unknown function (DUF2791)	-	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	DUF2791
CMS3_k127_301295_2	673860.AciM339_1221	3.211e-60	236.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota	28890|Euryarchaeota	K	DEAD H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C
CMS3_k127_3016839_1	595460.RRSWK_03720	1.278e-103	345.0	COG0601@1|root,COG0601@2|Bacteria,2IY87@203682|Planctomycetes	203682|Planctomycetes	U	Binding-protein-dependent transport system inner membrane component	oppB	-	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
CMS3_k127_3016839_0	314230.DSM3645_06806	4.284e-129	430.0	COG4166@1|root,COG4166@2|Bacteria,2IY5J@203682|Planctomycetes	203682|Planctomycetes	E	Bacterial extracellular solute-binding proteins, family 5 Middle	oppA	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
CMS3_k127_3016839_2	502025.Hoch_2519	0.0005913	44.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42N1P@68525|delta/epsilon subdivisions,2WM2V@28221|Deltaproteobacteria,2YU4D@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase	-	-	2.6.1.17,2.6.1.88	ko:K14267,ko:K14287	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475,R08618	RC00006,RC00025	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_3018012_2	234267.Acid_1623	8.951e-19	98.0	COG2801@1|root,COG2801@2|Bacteria,3Y821@57723|Acidobacteria	57723|Acidobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
CMS3_k127_3018012_0	41431.PCC8801_3596	9.84e-181	605.0	COG1413@1|root,COG1413@2|Bacteria,1G1H5@1117|Cyanobacteria,3KKAR@43988|Cyanothece	1117|Cyanobacteria	C	Domain of unknown function (DUF4132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132
CMS3_k127_3018012_1	696747.NIES39_C05180	2.541e-84	300.0	COG1520@1|root,COG2931@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,1GQUQ@1117|Cyanobacteria,1HBB3@1150|Oscillatoriales	1117|Cyanobacteria	G	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind
CMS3_k127_3022509_1	391625.PPSIR1_12803	5.929e-07	62.0	COG4932@1|root,COG4932@2|Bacteria,1PEGG@1224|Proteobacteria,43854@68525|delta/epsilon subdivisions,2X3F3@28221|Deltaproteobacteria,2YVTB@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_3022509_0	760192.Halhy_4981	4.929e-151	487.0	COG0308@1|root,COG0308@2|Bacteria,4NFNJ@976|Bacteroidetes,1IR1K@117747|Sphingobacteriia	976|Bacteroidetes	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
CMS3_k127_3022513_3	161934.XP_010669247.1	1.157e-72	258.0	COG0276@1|root,KOG1321@2759|Eukaryota,37IBX@33090|Viridiplantae,3GA7G@35493|Streptophyta	35493|Streptophyta	H	Catalyzes the ferrous insertion into protoporphyrin IX	-	GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009058,GO:0009507,GO:0009536,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
CMS3_k127_3022513_1	404589.Anae109_1129	2.233e-128	424.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42M87@68525|delta/epsilon subdivisions,2WMB0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS3_k127_3022513_2	338963.Pcar_0769	1.921e-74	274.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,42MV9@68525|delta/epsilon subdivisions,2WJZK@28221|Deltaproteobacteria,43S1P@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0016	URO-D
CMS3_k127_3022513_4	649638.Trad_0223	3.48e-61	219.0	COG0745@1|root,COG0745@2|Bacteria,1WM7Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_3022513_6	309801.trd_1599	1.519e-31	141.0	COG5002@1|root,COG5002@2|Bacteria,2G67W@200795|Chloroflexi,27XFQ@189775|Thermomicrobia	189775|Thermomicrobia	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS
CMS3_k127_3022513_0	1121920.AUAU01000004_gene698	4.608e-132	434.0	COG0001@1|root,COG0001@2|Bacteria,3Y3GA@57723|Acidobacteria	57723|Acidobacteria	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_3022513_5	1122221.JHVI01000010_gene2510	3.598e-37	155.0	COG0181@1|root,COG0181@2|Bacteria,1WM2C@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
CMS3_k127_3022928_1	756272.Plabr_0423	1.048e-31	127.0	COG3119@1|root,COG3119@2|Bacteria,2IXG7@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_3022928_0	886293.Sinac_2761	4.084e-96	351.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IYTQ@203682|Planctomycetes	203682|Planctomycetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16
CMS3_k127_3022928_2	886293.Sinac_7484	2.371e-08	60.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3043129_0	1336237.JAEE01000001_gene1731	1.301e-79	283.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051301,GO:0051704,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
CMS3_k127_3044225_0	269799.Gmet_1965	1.4e-104	360.0	COG3868@1|root,COG3868@2|Bacteria,1NXBJ@1224|Proteobacteria,430FT@68525|delta/epsilon subdivisions,2WVXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3044225_1	357808.RoseRS_1037	1.205e-12	79.0	COG1928@1|root,COG1928@2|Bacteria,2G8YA@200795|Chloroflexi,375IA@32061|Chloroflexia	32061|Chloroflexia	O	C-terminal four TMM region of protein-O-mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_30501_5	316274.Haur_4801	2.369e-14	74.0	298HU@1|root,2ZVNV@2|Bacteria,2GB3Z@200795|Chloroflexi,377VJ@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
CMS3_k127_30501_2	187272.Mlg_0268	1.206e-58	210.0	COG2928@1|root,COG2928@2|Bacteria,1R79M@1224|Proteobacteria,1S6CC@1236|Gammaproteobacteria,1WZFF@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
CMS3_k127_30501_3	1121430.JMLG01000002_gene1210	2.958e-35	150.0	COG4636@1|root,COG4636@2|Bacteria,1V1Q1@1239|Firmicutes,24G9A@186801|Clostridia,266ZQ@186807|Peptococcaceae	186801|Clostridia	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Uma2
CMS3_k127_30501_1	1049564.TevJSym_aa01890	7.145e-164	531.0	COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
CMS3_k127_30501_4	1237149.C900_03556	9.757e-20	96.0	2AN5I@1|root,31D3D@2|Bacteria,4NQTI@976|Bacteroidetes,47QVV@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4920)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4920
CMS3_k127_30501_0	641524.ADICYQ_5483	5.622e-164	542.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,4NHPU@976|Bacteroidetes,47KZ1@768503|Cytophagia	976|Bacteroidetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,HEAT_2
CMS3_k127_3062064_1	861299.J421_5625	2.069e-91	318.0	COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3,GSDH
CMS3_k127_3062064_2	1356852.N008_07370	3.772e-62	223.0	COG3145@1|root,COG3145@2|Bacteria,4NFEG@976|Bacteroidetes,47QWS@768503|Cytophagia	976|Bacteroidetes	L	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
CMS3_k127_3062064_3	1123508.JH636449_gene7247	1.312e-34	153.0	COG0515@1|root,COG0515@2|Bacteria,2IYAA@203682|Planctomycetes	203682|Planctomycetes	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_3062064_0	521674.Plim_1972	1.013e-166	536.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,2IXPN@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrom_C,GSDH,HEAT_2
CMS3_k127_3065593_1	521674.Plim_3010	0.0001861	53.0	COG1792@1|root,COG1792@2|Bacteria,2J54G@203682|Planctomycetes	203682|Planctomycetes	M	Involved in formation and maintenance of cell shape	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3065593_0	586416.GZ22_10755	6.633e-30	132.0	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,4HII3@91061|Bacilli	91061|Bacilli	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08510	CoaE
CMS3_k127_3067740_0	234267.Acid_3931	7.157e-257	824.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS3_k127_3067740_1	521674.Plim_2872	6.037e-52	194.0	2AU2S@1|root,31JP5@2|Bacteria,2IZEE@203682|Planctomycetes	203682|Planctomycetes	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS3_k127_3070034_1	1403819.BATR01000162_gene5326	1.54e-29	129.0	COG1073@1|root,COG1073@2|Bacteria,46T3P@74201|Verrucomicrobia,2IWCM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS3_k127_3070034_0	1185876.BN8_03195	5.418e-122	404.0	COG1073@1|root,COG1073@2|Bacteria,4NI6C@976|Bacteroidetes,47N3Z@768503|Cytophagia	976|Bacteroidetes	S	Acetyl xylan esterase	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
CMS3_k127_3070421_1	595460.RRSWK_02048	5.293e-78	268.0	COG0398@1|root,COG0398@2|Bacteria,2J2ZN@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547,SNARE_assoc
CMS3_k127_3070421_2	945713.IALB_0149	2.327e-31	128.0	COG4911@1|root,COG4911@2|Bacteria	2|Bacteria	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
CMS3_k127_3070421_3	1237149.C900_00978	1.81e-26	111.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	arsR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0046685,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
CMS3_k127_3070421_4	324057.Pjdr2_0623	6.517e-21	101.0	2E4GE@1|root,32ZBK@2|Bacteria,1U18T@1239|Firmicutes,4IAQY@91061|Bacilli,2731X@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3070421_6	1382359.JIAL01000001_gene1893	1.509e-09	68.0	COG0500@1|root,COG2226@2|Bacteria,3Y5PC@57723|Acidobacteria,2JJXN@204432|Acidobacteriia	204432|Acidobacteriia	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_3070421_5	391625.PPSIR1_32387	1.704e-13	74.0	COG1965@1|root,COG1965@2|Bacteria,1QAVK@1224|Proteobacteria,435BR@68525|delta/epsilon subdivisions,2WZP7@28221|Deltaproteobacteria,2Z2G9@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the frataxin family	cyaY	-	-	ko:K06202	-	-	-	-	ko00000	-	-	-	Frataxin_Cyay
CMS3_k127_3070421_0	234267.Acid_3582	1.155e-79	289.0	COG4262@1|root,COG4262@2|Bacteria,3Y6HM@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_30722_1	373994.Riv7116_0158	0.0002799	46.0	COG1413@1|root,COG5635@1|root,COG1413@2|Bacteria,COG5635@2|Bacteria,1G2R4@1117|Cyanobacteria,1HMQH@1161|Nostocales	1117|Cyanobacteria	CT	HEAT repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT,HEAT_2,HEAT_PBS
CMS3_k127_30722_0	530564.Psta_2519	4.093e-103	359.0	COG3345@1|root,COG3345@2|Bacteria,2J1YM@203682|Planctomycetes	203682|Planctomycetes	G	Pfam:DUF303	-	-	-	-	-	-	-	-	-	-	-	-	SASA
CMS3_k127_3082267_0	1089550.ATTH01000001_gene1987	6.231e-31	140.0	COG2866@1|root,COG2931@1|root,COG3291@1|root,COG2866@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,4NKIR@976|Bacteroidetes	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
CMS3_k127_3083791_1	1408473.JHXO01000009_gene3486	4.444e-73	254.0	COG2148@1|root,COG2148@2|Bacteria,4NER4@976|Bacteroidetes,2FNC2@200643|Bacteroidia	976|Bacteroidetes	M	Psort location CytoplasmicMembrane, score	-	-	-	ko:K13012	-	-	-	-	ko00000,ko01005	-	-	-	Bac_transf,CoA_binding_3
CMS3_k127_3083791_2	765912.Thimo_3075	1.627e-56	205.0	COG0500@1|root,COG2226@2|Bacteria,1RG8C@1224|Proteobacteria,1SSHV@1236|Gammaproteobacteria,1X1GD@135613|Chromatiales	135613|Chromatiales	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_3083791_0	153948.NAL212_0248	5.798e-197	643.0	COG1061@1|root,COG1112@1|root,COG1061@2|Bacteria,COG1112@2|Bacteria,1MWMG@1224|Proteobacteria,2VHWC@28216|Betaproteobacteria,373ZI@32003|Nitrosomonadales	28216|Betaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF559
CMS3_k127_309388_9	479432.Sros_8189	7.92e-05	51.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4EJ67@85012|Streptosporangiales	201174|Actinobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_309388_6	344747.PM8797T_31643	1.215e-55	209.0	COG1136@1|root,COG1136@2|Bacteria	2|Bacteria	V	lipoprotein transporter activity	-	-	-	ko:K02003,ko:K05685,ko:K09810	ko02010,map02010	M00255,M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12,3.A.1.125	-	-	ABC_tran
CMS3_k127_309388_1	344747.PM8797T_31638	6.642e-146	477.0	COG0725@1|root,COG0725@2|Bacteria,2J08C@203682|Planctomycetes	203682|Planctomycetes	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11
CMS3_k127_309388_3	867900.Celly_0862	1.383e-78	290.0	COG0555@1|root,COG0555@2|Bacteria	2|Bacteria	P	ATPase-coupled sulfate transmembrane transporter activity	modB1	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
CMS3_k127_309388_4	344747.PM8797T_31628	5.251e-62	231.0	COG3842@1|root,COG3842@2|Bacteria,2IZ85@203682|Planctomycetes	203682|Planctomycetes	E	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS3_k127_309388_2	344747.PM8797T_31618	3.338e-119	386.0	COG0476@1|root,COG0476@2|Bacteria,2IY5K@203682|Planctomycetes	203682|Planctomycetes	H	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
CMS3_k127_309388_5	945550.VISI1226_15071	4.399e-56	219.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1Y2H6@135623|Vibrionales	135623|Vibrionales	M	COG1404 Subtilisin-like serine proteases	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_S8
CMS3_k127_309388_7	1304878.AUGD01000003_gene2376	4.656e-31	128.0	2CGEX@1|root,32U4B@2|Bacteria,1MWWW@1224|Proteobacteria,2TT01@28211|Alphaproteobacteria,3JSQK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1579)	MA20_43845	-	-	-	-	-	-	-	-	-	-	-	DUF1579
CMS3_k127_309388_0	1144275.COCOR_05920	3.032e-146	471.0	COG2227@1|root,COG2227@2|Bacteria,1R6E0@1224|Proteobacteria,42ZTU@68525|delta/epsilon subdivisions,2WVFC@28221|Deltaproteobacteria,2YZN2@29|Myxococcales	28221|Deltaproteobacteria	H	RNA repair, ligase-Pnkp-associating, region of Hen1	ubiE2	-	-	-	-	-	-	-	-	-	-	-	Hen1_L,Methyltransf_23
CMS3_k127_3101007_1	391623.TERMP_00879	1.13e-27	116.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ0S@28890|Euryarchaeota,244B1@183968|Thermococci	183968|Thermococci	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
CMS3_k127_3101007_0	237368.SCABRO_00477	1.148e-172	567.0	COG1198@1|root,COG1198@2|Bacteria,2IY1F@203682|Planctomycetes	203682|Planctomycetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
CMS3_k127_3101018_2	1278073.MYSTI_07312	4.376e-32	127.0	COG0640@1|root,COG0640@2|Bacteria,1N0HB@1224|Proteobacteria	1224|Proteobacteria	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
CMS3_k127_3101018_0	243090.RB2377	1.703e-222	724.0	COG3119@1|root,COG3507@1|root,COG3119@2|Bacteria,COG3507@2|Bacteria,2J2K4@203682|Planctomycetes	203682|Planctomycetes	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS3_k127_3101018_1	886293.Sinac_7484	3.947e-41	162.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3103893_1	107635.AZUO01000001_gene2425	8.928e-34	141.0	COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,2U99K@28211|Alphaproteobacteria,370E2@31993|Methylocystaceae	28211|Alphaproteobacteria	S	transporter component	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	-
CMS3_k127_3103893_2	1168065.DOK_03533	2.166e-32	130.0	COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,1S95T@1236|Gammaproteobacteria,1J6H0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
CMS3_k127_3103893_4	1379270.AUXF01000004_gene3100	7.922e-09	66.0	COG0454@1|root,COG0454@2|Bacteria,1ZSVU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_3103893_0	525897.Dbac_2454	4.523e-87	308.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria,2M8CP@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS3_k127_3103893_3	595460.RRSWK_00209	1.463e-30	135.0	COG1657@1|root,COG1657@2|Bacteria,2IXAS@203682|Planctomycetes	203682|Planctomycetes	I	PFAM Prenyltransferase squalene oxidase	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	Prenyltrans,SQHop_cyclase_C
CMS3_k127_3112414_1	1435356.Y013_15330	7.326e-06	57.0	COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria,4FVSE@85025|Nocardiaceae	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS3_k127_3112414_0	1396418.BATQ01000185_gene2137	1.913e-166	537.0	COG0673@1|root,COG0673@2|Bacteria,46U2Q@74201|Verrucomicrobia,2IV92@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_3117808_0	1121859.KB890755_gene1122	3.221e-80	286.0	COG0657@1|root,COG0657@2|Bacteria,4NJ8D@976|Bacteroidetes	976|Bacteroidetes	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,DLH,Lipase_GDSL_2,Peptidase_S9
CMS3_k127_3117808_1	344747.PM8797T_08259	5.857e-59	223.0	COG2755@1|root,COG2755@2|Bacteria,2J2RC@203682|Planctomycetes	203682|Planctomycetes	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS3_k127_3117808_2	314230.DSM3645_11631	2.788e-36	143.0	COG1595@1|root,COG1595@2|Bacteria,2J3FS@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS3_k127_3118387_3	1129794.C427_1163	5.682e-05	53.0	COG1574@1|root,COG1574@2|Bacteria	2|Bacteria	G	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS3_k127_3118387_1	269797.Mbar_A2020	1.859e-40	166.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,2N9G1@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transferase
CMS3_k127_3118387_0	1183438.GKIL_3263	7.075e-65	250.0	COG1470@1|root,COG3391@1|root,COG1470@2|Bacteria,COG3391@2|Bacteria,1G0EB@1117|Cyanobacteria	1117|Cyanobacteria	DZ	PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,DUF4347,He_PIG,HemolysinCabind,PPC,VCBS
CMS3_k127_3118387_2	545694.TREPR_0758	1.192e-14	74.0	COG4864@1|root,COG4864@2|Bacteria,2J6J6@203691|Spirochaetes	203691|Spirochaetes	S	SigmaW regulon antibacterial	-	-	-	-	-	-	-	-	-	-	-	-	YdfA_immunity
CMS3_k127_312387_7	886293.Sinac_1616	1.248e-48	184.0	COG1595@1|root,COG1595@2|Bacteria,2IZMI@203682|Planctomycetes	203682|Planctomycetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
CMS3_k127_312387_0	1123242.JH636435_gene2097	3.344e-151	498.0	COG0515@1|root,COG0515@2|Bacteria,2IY73@203682|Planctomycetes	203682|Planctomycetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_312387_5	1123023.JIAI01000015_gene3217	5.591e-68	238.0	COG1794@1|root,COG1794@2|Bacteria,2H7J9@201174|Actinobacteria,4E0SW@85010|Pseudonocardiales	201174|Actinobacteria	M	Asp/Glu/Hydantoin racemase	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
CMS3_k127_312387_2	195250.CM001776_gene3867	2.806e-117	389.0	COG3608@1|root,COG3608@2|Bacteria,1G167@1117|Cyanobacteria	1117|Cyanobacteria	S	succinylglutamate desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
CMS3_k127_312387_1	118168.MC7420_5523	1.576e-117	380.0	COG0189@1|root,COG0189@2|Bacteria,1G0DT@1117|Cyanobacteria,1H6ZT@1150|Oscillatoriales	1117|Cyanobacteria	F	Belongs to the RimK family	rimK	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK,Zn_protease
CMS3_k127_312387_8	1229780.BN381_290116	6.971e-30	122.0	COG0189@1|root,COG0189@2|Bacteria,2HXBM@201174|Actinobacteria,3UX4W@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Belongs to the RimK family	rimK	-	6.3.2.43	ko:K05827,ko:K05844	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	RimK,TrkA_C
CMS3_k127_312387_6	1173264.KI913949_gene3345	5.455e-49	182.0	COG4067@1|root,COG4067@2|Bacteria,1G6KI@1117|Cyanobacteria,1HBYC@1150|Oscillatoriales	1117|Cyanobacteria	O	Putative ATP-dependant zinc protease	-	-	-	-	-	-	-	-	-	-	-	-	Zn_protease
CMS3_k127_312387_4	794903.OPIT5_23810	5.715e-88	314.0	2DZRA@1|root,32VGT@2|Bacteria,46TAC@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GHL10
CMS3_k127_312387_3	595460.RRSWK_03194	1.656e-90	306.0	COG2239@1|root,COG2239@2|Bacteria,2IYCZ@203682|Planctomycetes	203682|Planctomycetes	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
CMS3_k127_3129108_3	105559.Nwat_0324	1.864e-16	89.0	COG1876@1|root,COG3409@1|root,COG1876@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	3D,PG_binding_1,VanY
CMS3_k127_3129108_1	105559.Nwat_0323	2.836e-121	399.0	COG0156@1|root,COG0156@2|Bacteria,1RK31@1224|Proteobacteria	1224|Proteobacteria	H	8-amino-7-oxononanoate synthase activity	-	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_3129108_0	29581.BW37_04116	2.879e-159	522.0	28HPE@1|root,2Z7XE@2|Bacteria,1PV34@1224|Proteobacteria,2VIAY@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3129108_2	29581.BW37_04115	2.357e-92	312.0	28JJ9@1|root,2Z9CC@2|Bacteria,1R4HT@1224|Proteobacteria,2VNXY@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3138691_1	84531.JMTZ01000036_gene478	1.685e-31	139.0	COG0500@1|root,COG2226@2|Bacteria,1PE3F@1224|Proteobacteria,1SSKY@1236|Gammaproteobacteria,1X5Z7@135614|Xanthomonadales	135614|Xanthomonadales	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_3138691_2	1120936.KB907213_gene4762	3.749e-05	51.0	COG1595@1|root,COG1595@2|Bacteria,2IRNG@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3138691_0	118168.MC7420_7908	3.107e-63	243.0	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1H7TA@1150|Oscillatoriales	1117|Cyanobacteria	M	Wd40 repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,WD40
CMS3_k127_3143505_0	1278073.MYSTI_01094	4.406e-176	563.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2WJ3T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS3_k127_3143505_1	930166.CD58_23105	1.536e-18	100.0	COG0500@1|root,COG0500@2|Bacteria,1NIZX@1224|Proteobacteria,1T2CR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_3146615_2	869210.Marky_0738	1.016e-58	208.0	COG1208@1|root,COG1208@2|Bacteria,1WJT1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	JM	COGs COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon)	-	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
CMS3_k127_3146615_0	1173028.ANKO01000130_gene1837	1.266e-84	289.0	COG1922@1|root,COG1922@2|Bacteria,1G2U3@1117|Cyanobacteria,1HF84@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferase WecB/TagA/CpsF family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
CMS3_k127_3146615_1	589865.DaAHT2_1766	9.679e-69	250.0	COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,42TSF@68525|delta/epsilon subdivisions,2X5F6@28221|Deltaproteobacteria,2MM40@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
CMS3_k127_3150094_0	502025.Hoch_4016	0.0	1971.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2YUEA@29|Myxococcales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
CMS3_k127_3150094_1	1192034.CAP_5631	3.18e-101	331.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2YUJI@29|Myxococcales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
CMS3_k127_3153018_0	452637.Oter_3284	5.201e-65	249.0	COG2909@1|root,COG3710@1|root,COG2909@2|Bacteria,COG3710@2|Bacteria,46UY3@74201|Verrucomicrobia	74201|Verrucomicrobia	K	PFAM transcriptional regulator domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
CMS3_k127_3153018_2	509190.Cseg_0094	4.276e-26	110.0	2C82G@1|root,32RK9@2|Bacteria,1MZV5@1224|Proteobacteria,2UCEY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
CMS3_k127_3153018_1	452637.Oter_3282	2.971e-41	159.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
CMS3_k127_3164423_0	1411123.JQNH01000001_gene537	6.394e-263	830.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	P-type ATPase'	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
CMS3_k127_3168186_2	344747.PM8797T_09879	5.475e-71	261.0	COG1914@1|root,COG1914@2|Bacteria,2IZ88@203682|Planctomycetes	203682|Planctomycetes	P	Cytochrome ba3-putative manganese transport protein mntH	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
CMS3_k127_3168186_1	1041159.AZUW01000036_gene875	3.598e-91	317.0	COG4948@1|root,COG4948@2|Bacteria,1MV2S@1224|Proteobacteria,2TTFB@28211|Alphaproteobacteria,4BA6Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Mandelate Racemase Muconate Lactonizing	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C
CMS3_k127_3168186_0	234267.Acid_2676	1.413e-214	674.0	COG0620@1|root,COG0620@2|Bacteria,3Y8ZA@57723|Acidobacteria	57723|Acidobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
CMS3_k127_3178593_4	467200.ACFA01000289_gene3271	2.721e-11	76.0	COG1595@1|root,COG3409@1|root,COG1595@2|Bacteria,COG3409@2|Bacteria,2I59P@201174|Actinobacteria	201174|Actinobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3178593_2	1128421.JAGA01000002_gene1113	2.26e-31	134.0	COG1682@1|root,COG1682@2|Bacteria	2|Bacteria	GM	macromolecule localization	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
CMS3_k127_3178593_0	671143.DAMO_0252	5.169e-95	326.0	COG1134@1|root,COG1134@2|Bacteria,2NP4S@2323|unclassified Bacteria	2|Bacteria	GM	ATPases associated with a variety of cellular activities	-	-	3.6.3.38	ko:K09689,ko:K09691	ko02010,map02010	M00249,M00250	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101,3.A.1.103	-	-	ABC_tran,Wzt_C
CMS3_k127_3178593_1	671143.DAMO_0249	1.951e-49	193.0	COG1216@1|root,COG1216@2|Bacteria,2NP9Z@2323|unclassified Bacteria	2|Bacteria	GM	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
CMS3_k127_3178593_3	279238.Saro_3226	1.336e-15	81.0	COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,2TRZB@28211|Alphaproteobacteria,2K4XC@204457|Sphingomonadales	204457|Sphingomonadales	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_318091_10	626887.J057_08586	1.476e-05	48.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,1S25T@1236|Gammaproteobacteria,46AP6@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	blaB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,NUDIX
CMS3_k127_318091_4	671143.DAMO_1646	6.597e-55	210.0	COG0763@1|root,COG0763@2|Bacteria,2NP10@2323|unclassified Bacteria	2|Bacteria	I	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
CMS3_k127_318091_9	760011.Spico_0734	7.885e-07	61.0	COG0477@1|root,COG2814@2|Bacteria,2JAP5@203691|Spirochaetes	203691|Spirochaetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08153,ko:K19576	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.10,2.A.1.2.8	-	-	MFS_1
CMS3_k127_318091_11	755731.Clo1100_2563	0.0006506	52.0	COG1277@1|root,COG1277@2|Bacteria,1V6DZ@1239|Firmicutes,249IM@186801|Clostridia,36FRC@31979|Clostridiaceae	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
CMS3_k127_318091_6	309801.trd_0013	3.468e-41	163.0	COG1131@1|root,COG1131@2|Bacteria,2G5QI@200795|Chloroflexi,27XXC@189775|Thermomicrobia	189775|Thermomicrobia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_318091_5	187272.Mlg_2249	3.812e-52	191.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1WVVN@135613|Chromatiales	135613|Chromatiales	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
CMS3_k127_318091_3	1089553.Tph_c28850	1.059e-73	268.0	COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia,42H8N@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM TrkA-N domain protein	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS3_k127_318091_2	768704.Desmer_0813	3.756e-87	309.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,260IQ@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM potassium uptake protein, TrkH family	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS3_k127_318091_7	344747.PM8797T_15181	8.348e-31	124.0	COG2331@1|root,COG2331@2|Bacteria,2J0TW@203682|Planctomycetes	203682|Planctomycetes	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
CMS3_k127_318091_8	439375.Oant_0180	6.855e-29	123.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2U5V2@28211|Alphaproteobacteria,1J1XD@118882|Brucellaceae	28211|Alphaproteobacteria	J	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
CMS3_k127_318091_1	1232410.KI421424_gene1723	3.14e-115	383.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,43SEG@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	DnaJ central domain	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
CMS3_k127_318091_0	344747.PM8797T_15196	1.325e-186	594.0	COG0459@1|root,COG0459@2|Bacteria,2IXJW@203682|Planctomycetes	203682|Planctomycetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS3_k127_3181363_1	1396418.BATQ01000113_gene4690	0.0002878	52.0	COG4848@1|root,COG4848@2|Bacteria,46XEG@74201|Verrucomicrobia,2IVNN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Protein of unknown function (DUF1444)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1444
CMS3_k127_3181363_0	246197.MXAN_0146	5.161e-06	60.0	COG4932@1|root,COG4932@2|Bacteria,1PEGG@1224|Proteobacteria,43854@68525|delta/epsilon subdivisions,2X3F3@28221|Deltaproteobacteria,2YVTB@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_318502_1	452637.Oter_0303	2.7e-90	310.0	COG0306@1|root,COG0306@2|Bacteria	2|Bacteria	P	phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
CMS3_k127_318502_0	278957.ABEA03000041_gene2050	1.035e-94	338.0	COG5434@1|root,COG5434@2|Bacteria,46U2F@74201|Verrucomicrobia,3K9E5@414999|Opitutae	414999|Opitutae	M	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_318502_2	794903.OPIT5_03645	1.66e-42	161.0	COG5434@1|root,COG5434@2|Bacteria,46U2F@74201|Verrucomicrobia,3K9E5@414999|Opitutae	414999|Opitutae	M	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3200630_0	886293.Sinac_3627	2.897e-69	264.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_8,WD40
CMS3_k127_3204157_0	1118235.CAJH01000019_gene1036	5.281e-199	626.0	COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,1RPG4@1236|Gammaproteobacteria,1X3M6@135614|Xanthomonadales	135614|Xanthomonadales	C	NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
CMS3_k127_3204157_1	1211115.ALIQ01000212_gene3277	1.27e-47	182.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,3NAHN@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	phoB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_3204157_3	349161.Dred_1902	1.848e-21	109.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,260UH@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K10681	ko02020,map02020	M00468	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_3204157_4	314230.DSM3645_14280	1.382e-18	99.0	COG1657@1|root,COG1657@2|Bacteria,2IXVT@203682|Planctomycetes	203682|Planctomycetes	I	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	A2M_comp,DUF4159,Prenyltrans
CMS3_k127_3204157_2	1379698.RBG1_1C00001G0011	1.03e-31	138.0	COG2010@1|root,COG2180@1|root,COG2010@2|Bacteria,COG2180@2|Bacteria,2NR8D@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c	narJ	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057	-	ko:K00373,ko:K00405,ko:K17052	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko02000	3.D.4.3,5.A.3.8	-	iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687	Nitrate_red_del
CMS3_k127_3208814_0	1089547.KB913013_gene2350	6.698e-73	269.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,4NHPU@976|Bacteroidetes,47KZ1@768503|Cytophagia	976|Bacteroidetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,HEAT_2
CMS3_k127_3209475_0	717605.Theco_0340	5.905e-15	89.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HC17@91061|Bacilli,26TDT@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3215268_0	1121861.KB899911_gene1186	7.54e-196	646.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JQXF@204441|Rhodospirillales	28211|Alphaproteobacteria	E	COG0367 Asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS3_k127_3215268_3	886293.Sinac_1555	1.731e-09	70.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
CMS3_k127_3215268_2	886293.Sinac_1102	2.35e-30	122.0	COG0526@1|root,COG0526@2|Bacteria,2J07Q@203682|Planctomycetes	203682|Planctomycetes	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_3215268_1	471854.Dfer_2527	2.767e-33	147.0	COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
CMS3_k127_3216716_2	1121406.JAEX01000001_gene299	4.507e-130	428.0	COG0391@1|root,COG0391@2|Bacteria,1NW3K@1224|Proteobacteria,42QAP@68525|delta/epsilon subdivisions,2WIZS@28221|Deltaproteobacteria,2M7XZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0052	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
CMS3_k127_3216716_0	313628.LNTAR_22304	4.478e-174	564.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_3216716_1	573370.DMR_11640	2.598e-147	484.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MAFI@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	pfam abc1	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
CMS3_k127_3216716_3	1120973.AQXL01000133_gene1699	1.649e-08	63.0	COG2936@1|root,COG2936@2|Bacteria,1TT0H@1239|Firmicutes,4HB0H@91061|Bacilli	91061|Bacilli	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	cocE	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS3_k127_3217083_2	864702.OsccyDRAFT_4520	3.447e-34	139.0	COG1215@1|root,COG1215@2|Bacteria,1GQPQ@1117|Cyanobacteria,1H9XR@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
CMS3_k127_3217083_0	118168.MC7420_5089	3.358e-128	427.0	COG0438@1|root,COG0438@2|Bacteria,1G1ED@1117|Cyanobacteria,1H79T@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferases group 1	-	-	-	ko:K16703	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_3217083_1	1116369.KB890025_gene5123	4.42e-43	168.0	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria	1224|Proteobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
CMS3_k127_3221974_2	1545915.JROG01000003_gene778	2.096e-56	221.0	COG0515@1|root,3345A@2|Bacteria,1NSRF@1224|Proteobacteria	1224|Proteobacteria	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3221974_1	644966.Tmar_0407	1.564e-66	233.0	COG1845@1|root,COG1845@2|Bacteria,1TQJ1@1239|Firmicutes,24SBR@186801|Clostridia	186801|Clostridia	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
CMS3_k127_3221974_5	204669.Acid345_0439	3.686e-31	128.0	COG1845@1|root,COG1845@2|Bacteria,3Y2KJ@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
CMS3_k127_3221974_0	153721.MYP_4746	1.654e-189	607.0	COG0843@1|root,COG0843@2|Bacteria,4NEH8@976|Bacteroidetes,47JBQ@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the heme-copper respiratory oxidase family	coxN	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
CMS3_k127_3221974_3	587753.EY04_01000	2.674e-55	204.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MVYW@1224|Proteobacteria,1RY2R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
CMS3_k127_3221974_4	234267.Acid_4384	6.934e-44	169.0	COG3794@1|root,COG3794@2|Bacteria,3Y4A0@57723|Acidobacteria	57723|Acidobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_32224_0	1131553.JIBI01000016_gene599	1.754e-102	351.0	COG3852@1|root,COG4251@1|root,COG3852@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2WHKT@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS3_k127_32224_1	443254.Marpi_1891	1.168e-38	158.0	COG0557@1|root,COG0557@2|Bacteria,2GC0U@200918|Thermotogae	200918|Thermotogae	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
CMS3_k127_3227269_3	373903.Hore_04930	8.818e-50	187.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3WAG7@53433|Halanaerobiales	186801|Clostridia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain	-	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_3227269_2	1499967.BAYZ01000136_gene40	1.098e-75	275.0	COG4239@1|root,COG4239@2|Bacteria	2|Bacteria	P	microcin transport	yejE	-	-	ko:K13895	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1,OppC_N
CMS3_k127_3227269_1	1265505.ATUG01000003_gene360	1.419e-101	342.0	COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,43BKS@68525|delta/epsilon subdivisions,2X6YW@28221|Deltaproteobacteria,2MIBW@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K13894	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
CMS3_k127_3227269_0	1499967.BAYZ01000136_gene42	5.975e-138	460.0	COG4166@1|root,COG4166@2|Bacteria	2|Bacteria	E	transmembrane transport	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
CMS3_k127_3238059_0	1125863.JAFN01000001_gene3506	7.208e-49	198.0	COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,Ras
CMS3_k127_3238059_1	439235.Dalk_3400	1.044e-34	153.0	COG4251@1|root,COG5000@1|root,COG4251@2|Bacteria,COG5000@2|Bacteria,1NSQ1@1224|Proteobacteria,42RAK@68525|delta/epsilon subdivisions,2WMP9@28221|Deltaproteobacteria,2MPMH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,dCache_1
CMS3_k127_3245752_0	1121403.AUCV01000059_gene3338	2.095e-20	95.0	COG0628@1|root,COG0628@2|Bacteria,1NG06@1224|Proteobacteria,42RH3@68525|delta/epsilon subdivisions,2WUIC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transmembrane protein 43	-	-	-	-	-	-	-	-	-	-	-	-	TMEM43
CMS3_k127_3245752_1	404589.Anae109_3393	0.0001093	53.0	COG0457@1|root,COG0457@2|Bacteria,1QX7S@1224|Proteobacteria,43C0S@68525|delta/epsilon subdivisions,2X7BD@28221|Deltaproteobacteria,2YV1Y@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3249308_0	391625.PPSIR1_40710	3.958e-135	438.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,2Z21X@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
CMS3_k127_3249308_2	324602.Caur_1789	0.0008542	51.0	COG0457@1|root,COG0457@2|Bacteria,2G9ET@200795|Chloroflexi,377NS@32061|Chloroflexia	32061|Chloroflexia	NU	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
CMS3_k127_3249308_1	1201293.AKXQ01000016_gene3529	5.55e-52	201.0	COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,1RZK1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
CMS3_k127_3250105_2	886293.Sinac_2798	1.453e-22	105.0	COG2010@1|root,COG2010@2|Bacteria,2IX5D@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
CMS3_k127_3250105_0	521674.Plim_4022	2.816e-157	509.0	COG0823@1|root,COG0823@2|Bacteria,2J1XG@203682|Planctomycetes	203682|Planctomycetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3250105_1	756272.Plabr_0265	1.967e-96	331.0	COG2211@1|root,COG2211@2|Bacteria,2IY9C@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_3250105_3	642492.Clole_2930	2.699e-19	93.0	COG1416@1|root,COG1416@2|Bacteria,1UJJV@1239|Firmicutes	1239|Firmicutes	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
CMS3_k127_3258691_0	595460.RRSWK_06781	4.297e-244	764.0	COG3119@1|root,COG3119@2|Bacteria,2IYMC@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_3258691_2	530564.Psta_0306	1.602e-15	89.0	COG3748@1|root,COG3748@2|Bacteria,2IXND@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1585)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt3,PSD2,PSD4
CMS3_k127_3269336_1	886293.Sinac_3442	5.339e-16	94.0	COG0526@1|root,COG1470@1|root,COG1595@1|root,COG0526@2|Bacteria,COG1470@2|Bacteria,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	AhpC-TSA,DUF4384,NPCBM_assoc,PEGA,Sigma70_r2,Sigma70_r4_2,Thioredoxin_8
CMS3_k127_3269336_0	749927.AMED_3284	2.27e-283	899.0	COG0110@1|root,COG0663@1|root,COG1020@1|root,COG0110@2|Bacteria,COG0663@2|Bacteria,COG1020@2|Bacteria,2I8TI@201174|Actinobacteria,4DZ27@85010|Pseudonocardiales	201174|Actinobacteria	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,PP-binding
CMS3_k127_3271259_4	292.DM42_975	3.417e-08	67.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VRGJ@28216|Betaproteobacteria,1K0H4@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3271259_5	46234.ANA_C20460	1.455e-07	65.0	COG3420@1|root,COG3420@2|Bacteria,1G2FG@1117|Cyanobacteria,1HJSK@1161|Nostocales	1117|Cyanobacteria	P	TIGRFAM parallel beta-helix repeat (two copies)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1565,SLH
CMS3_k127_3271259_3	344747.PM8797T_21603	9.332e-10	71.0	COG1520@1|root,COG1520@2|Bacteria,2IX37@203682|Planctomycetes	203682|Planctomycetes	S	protein kinase related protein	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_3271259_0	379066.GAU_2028	1.911e-197	634.0	COG2936@1|root,COG2936@2|Bacteria,1ZTD6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS3_k127_3271259_2	102125.Xen7305DRAFT_00010680	5.025e-32	134.0	arCOG10317@1|root,2Z7VW@2|Bacteria,1GEMN@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3271259_1	1079460.ATTQ01000001_gene5464	9.948e-137	439.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
CMS3_k127_3279035_2	573370.DMR_17570	2.762e-38	152.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,42MSV@68525|delta/epsilon subdivisions,2WJ6U@28221|Deltaproteobacteria,2M8X8@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM glycosyl transferase family 51	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
CMS3_k127_3279035_1	344747.PM8797T_08629	1.269e-97	335.0	COG1520@1|root,COG1520@2|Bacteria,2J26V@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_3279035_0	1122939.ATUD01000001_gene577	2.824e-166	564.0	COG1520@1|root,COG1520@2|Bacteria,2H3K4@201174|Actinobacteria,4CRJK@84995|Rubrobacteria	84995|Rubrobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3294349_3	497964.CfE428DRAFT_4478	0.0001306	55.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,46UMD@74201|Verrucomicrobia	2|Bacteria	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
CMS3_k127_3294349_1	886293.Sinac_7484	8.535e-51	189.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3294349_0	243090.RB12858	3.014e-118	393.0	COG4608@1|root,COG4608@2|Bacteria,2IX9Z@203682|Planctomycetes	203682|Planctomycetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_3294349_2	1231392.OCGS_2294	1.095e-33	132.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	oppD	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_3302205_0	1449044.JMLE01000024_gene302	2.972e-75	263.0	COG0667@1|root,COG0667@2|Bacteria,2GMRW@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS3_k127_3302205_2	1223545.GS4_08_00980	3.616e-13	83.0	COG0477@1|root,COG0477@2|Bacteria,2GJSC@201174|Actinobacteria,4GADG@85026|Gordoniaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,MFS_1
CMS3_k127_3302205_3	1380355.JNIJ01000020_gene3741	2.855e-05	51.0	2FH9D@1|root,3493Q@2|Bacteria,1ND9G@1224|Proteobacteria,2UJ2Y@28211|Alphaproteobacteria,3K4PQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
CMS3_k127_3302205_1	867845.KI911784_gene2277	1.048e-47	196.0	COG0457@1|root,COG1404@1|root,COG3055@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,COG3055@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
CMS3_k127_3302205_4	1429851.X548_19410	7.147e-05	56.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,1S0IU@1236|Gammaproteobacteria,1X52Q@135614|Xanthomonadales	135614|Xanthomonadales	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12,TPR_8
CMS3_k127_3307596_0	1502851.FG93_04653	2.307e-14	75.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria,3JXB7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
CMS3_k127_3307596_1	867845.KI911784_gene2277	4.258e-14	81.0	COG0457@1|root,COG1404@1|root,COG3055@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,COG3055@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
CMS3_k127_3309266_1	240015.ACP_1172	5.354e-20	106.0	COG0457@1|root,COG0457@2|Bacteria,3Y77J@57723|Acidobacteria,2JM29@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
CMS3_k127_3309266_0	1210884.HG799474_gene15121	1.093e-57	219.0	COG0084@1|root,COG0084@2|Bacteria,2IZ3Q@203682|Planctomycetes	203682|Planctomycetes	L	COG0084 Mg-dependent DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM,TatD_DNase
CMS3_k127_3309266_2	1173023.KE650771_gene4898	5.994e-05	56.0	COG1749@1|root,COG3525@1|root,COG1749@2|Bacteria,COG3525@2|Bacteria,1GBDW@1117|Cyanobacteria	1117|Cyanobacteria	N	Domain of unknown function (DUF4082)	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082
CMS3_k127_3312072_1	157072.XP_008875843.1	2.627e-08	67.0	KOG4569@1|root,KOG4569@2759|Eukaryota	2759|Eukaryota	G	phospholipase A1 activity	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_3
CMS3_k127_3312072_0	1183438.GKIL_3942	2.107e-38	153.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
CMS3_k127_3312072_2	329726.AM1_0716	1.68e-05	47.0	COG1672@1|root,COG2319@1|root,COG3064@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,COG3064@2|Bacteria,1G07E@1117|Cyanobacteria	1117|Cyanobacteria	M	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35,WD40
CMS3_k127_3315975_4	1123257.AUFV01000011_gene3155	1.042e-07	66.0	COG3453@1|root,COG3453@2|Bacteria,1N919@1224|Proteobacteria,1SEMT@1236|Gammaproteobacteria,1X8A2@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative phosphatase (DUF442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
CMS3_k127_3315975_2	1107311.Q767_01620	6.656e-15	89.0	COG3291@1|root,COG3386@1|root,COG5306@1|root,COG3291@2|Bacteria,COG3386@2|Bacteria,COG5306@2|Bacteria,4PM1B@976|Bacteroidetes	976|Bacteroidetes	G	SPTR Cell surface protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3315975_0	886293.Sinac_1102	4.198e-33	130.0	COG0526@1|root,COG0526@2|Bacteria,2J07Q@203682|Planctomycetes	203682|Planctomycetes	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_3315975_3	1210884.HG799463_gene10186	1.089e-13	81.0	COG0526@1|root,COG0526@2|Bacteria,2J07Q@203682|Planctomycetes	203682|Planctomycetes	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_3315975_1	760192.Halhy_2468	6.881e-29	133.0	COG0457@1|root,COG0457@2|Bacteria,4NMZG@976|Bacteroidetes,1IZUU@117747|Sphingobacteriia	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF1736,PMT_2,TPR_16,TPR_2,TPR_8
CMS3_k127_3316648_3	1487953.JMKF01000060_gene4820	2.798e-26	117.0	COG0500@1|root,COG0500@2|Bacteria,1G0VE@1117|Cyanobacteria,1H79C@1150|Oscillatoriales	1117|Cyanobacteria	Q	TIGRFAM DNA phosphorothioation-associated	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3316648_0	1229172.JQFA01000004_gene1087	1.378e-76	270.0	COG0500@1|root,COG0500@2|Bacteria,1G0VE@1117|Cyanobacteria,1HE3Y@1150|Oscillatoriales	1117|Cyanobacteria	Q	TIGRFAM DNA phosphorothioation-associated	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3316648_2	208439.AJAP_03455	2.183e-43	162.0	arCOG09464@1|root,307RI@2|Bacteria,2IN99@201174|Actinobacteria	201174|Actinobacteria	S	DNA sulphur modification protein DndE	dndE	-	-	ko:K19172	-	-	-	-	ko00000,ko02048	-	-	-	DndE
CMS3_k127_3316648_1	208439.AJAP_03450	3.806e-64	228.0	COG0419@1|root,COG0419@2|Bacteria,2GRZQ@201174|Actinobacteria	201174|Actinobacteria	L	COG0419 ATPase involved in DNA repair	-	-	-	ko:K19171	-	-	-	-	ko00000,ko02048	-	-	-	AAA_23
CMS3_k127_3318621_0	867845.KI911784_gene2277	6.185e-57	217.0	COG0457@1|root,COG1404@1|root,COG3055@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,COG3055@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
CMS3_k127_3318621_1	756883.Halar_1883	7.973e-15	85.0	COG0589@1|root,arCOG02053@2157|Archaea	2157|Archaea	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_3318621_2	1173264.KI913949_gene1725	5.942e-14	84.0	COG0265@1|root,COG1413@1|root,COG5635@1|root,COG0265@2|Bacteria,COG1413@2|Bacteria,COG5635@2|Bacteria,1G233@1117|Cyanobacteria,1H7RE@1150|Oscillatoriales	1117|Cyanobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Metallophos,NACHT,Trypsin_2
CMS3_k127_3330449_0	1123242.JH636438_gene5735	1.327e-53	197.0	COG1842@1|root,COG1842@2|Bacteria	2|Bacteria	KT	Phage shock protein A	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
CMS3_k127_3330449_2	1123242.JH636438_gene5737	6.514e-29	129.0	COG4191@1|root,COG4191@2|Bacteria,2J2BM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS3_k127_3337511_1	497964.CfE428DRAFT_5953	2.615e-34	139.0	COG0642@1|root,COG2205@2|Bacteria,46Z6V@74201|Verrucomicrobia	74201|Verrucomicrobia	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS3_k127_3337511_0	1237149.C900_04559	4.753e-66	233.0	COG0745@1|root,COG0745@2|Bacteria,4NIQC@976|Bacteroidetes,47PDQ@768503|Cytophagia	976|Bacteroidetes	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_3341413_0	443143.GM18_3840	8.306e-75	274.0	COG0784@1|root,COG4191@1|root,COG5002@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
CMS3_k127_3341413_2	682795.AciX8_2268	5.329e-05	50.0	COG3119@1|root,COG3119@2|Bacteria,3Y679@57723|Acidobacteria,2JMM2@204432|Acidobacteriia	204432|Acidobacteriia	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_3341413_1	1121448.DGI_1524	1.07e-40	166.0	COG3291@1|root,COG3291@2|Bacteria,1PHGX@1224|Proteobacteria,437VV@68525|delta/epsilon subdivisions,2X1BB@28221|Deltaproteobacteria,2MEPR@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_5
CMS3_k127_334286_2	1121430.JMLG01000001_gene2251	8.737e-40	161.0	COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,2481R@186801|Clostridia,260ZV@186807|Peptococcaceae	186801|Clostridia	P	transporter (mgtE)	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
CMS3_k127_334286_3	886293.Sinac_2330	2.658e-16	91.0	COG0526@1|root,COG0526@2|Bacteria,2J0JE@203682|Planctomycetes	203682|Planctomycetes	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_334286_1	525904.Tter_0425	8.421e-106	357.0	COG0627@1|root,COG0627@2|Bacteria,2NQQ3@2323|unclassified Bacteria	2|Bacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS3_k127_334286_0	1125863.JAFN01000001_gene929	2.096e-180	591.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
CMS3_k127_3360492_2	338966.Ppro_3419	1.922e-25	109.0	COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,42RF8@68525|delta/epsilon subdivisions,2WQRY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Response regulator receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
CMS3_k127_3360492_1	324602.Caur_0649	2.239e-61	238.0	COG1404@1|root,COG4447@1|root,COG1404@2|Bacteria,COG4447@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
CMS3_k127_3360492_0	671143.DAMO_2568	2.428e-85	294.0	COG1432@1|root,COG1432@2|Bacteria,2NQWI@2323|unclassified Bacteria	2|Bacteria	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
CMS3_k127_3363050_3	616991.JPOO01000001_gene4100	6.22e-09	66.0	2BFSG@1|root,329MB@2|Bacteria,4NRMX@976|Bacteroidetes,1I6UN@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3363050_0	1313421.JHBV01000020_gene5292	9.367e-160	533.0	COG1409@1|root,COG1409@2|Bacteria,4NGK2@976|Bacteroidetes,1IWCK@117747|Sphingobacteriia	976|Bacteroidetes	S	Purple acid Phosphatase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
CMS3_k127_3363050_1	323098.Nwi_0261	3.471e-83	286.0	COG2253@1|root,COG2253@2|Bacteria,1R77W@1224|Proteobacteria,2U3HZ@28211|Alphaproteobacteria,3K5DM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS3_k127_3363050_2	398767.Glov_1417	1.325e-48	186.0	COG5340@1|root,COG5340@2|Bacteria,1R80Q@1224|Proteobacteria	1224|Proteobacteria	K	AbiEi antitoxin C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_1,AbiEi_4
CMS3_k127_3364519_5	1242864.D187_001420	6.321e-06	59.0	2FAP7@1|root,342WV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3364519_4	1340493.JNIF01000003_gene2940	3.859e-13	83.0	COG0612@1|root,COG0612@2|Bacteria,3Y3M9@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_3364519_3	391625.PPSIR1_11110	2.301e-71	255.0	COG2988@1|root,COG2988@2|Bacteria	2|Bacteria	E	succinylglutamate desuccinylase activity	astE	-	3.5.1.96	ko:K05526	ko00330,ko01100,map00330,map01100	-	R00411	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	AstE_AspA
CMS3_k127_3364519_0	1254432.SCE1572_00290	7.845e-245	778.0	COG0517@1|root,COG0517@2|Bacteria,1QZT1@1224|Proteobacteria,43CN4@68525|delta/epsilon subdivisions,2X7VC@28221|Deltaproteobacteria,2Z3IG@29|Myxococcales	28221|Deltaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS3_k127_3364519_2	502025.Hoch_4694	1.357e-96	322.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,42MMS@68525|delta/epsilon subdivisions,2WMUI@28221|Deltaproteobacteria,2YUWH@29|Myxococcales	28221|Deltaproteobacteria	L	TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM,TatD_DNase
CMS3_k127_3364519_1	215803.DB30_4063	1.087e-100	338.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,42PGV@68525|delta/epsilon subdivisions,2WIS0@28221|Deltaproteobacteria,2YZVC@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
CMS3_k127_3367842_2	706587.Desti_2437	1.567e-07	63.0	COG0457@1|root,COG0457@2|Bacteria,1R1JQ@1224|Proteobacteria,4377S@68525|delta/epsilon subdivisions,2WTFW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
CMS3_k127_3367842_0	671143.DAMO_2917	7.159e-196	636.0	COG0667@1|root,COG1331@1|root,COG0667@2|Bacteria,COG1331@2|Bacteria,2NP26@2323|unclassified Bacteria	2|Bacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,GlcNAc_2-epim,Thioredox_DsbH
CMS3_k127_3367842_1	1382359.JIAL01000001_gene779	5.507e-10	72.0	COG3595@1|root,COG3595@2|Bacteria,3Y3K3@57723|Acidobacteria,2JHKF@204432|Acidobacteriia	204432|Acidobacteriia	C	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS3_k127_3371669_1	314285.KT71_11690	2.385e-91	307.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1RPGK@1236|Gammaproteobacteria,1J5MH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	and related enzymes	yghX	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
CMS3_k127_3371669_2	344747.PM8797T_22568	1.22e-08	66.0	2EPBI@1|root,33GYA@2|Bacteria,2J1HU@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3371669_0	179408.Osc7112_1209	1.222e-164	529.0	COG0798@1|root,COG0798@2|Bacteria,1G05E@1117|Cyanobacteria,1H747@1150|Oscillatoriales	1117|Cyanobacteria	P	PFAM Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
CMS3_k127_3371669_3	1122917.KB899660_gene1472	6.403e-07	63.0	COG1595@1|root,COG1595@2|Bacteria,1V9BR@1239|Firmicutes,4HJ5P@91061|Bacilli,26VP7@186822|Paenibacillaceae	91061|Bacilli	K	the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription	M1-584	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_3387528_3	903818.KI912268_gene1040	1.459e-17	98.0	COG2214@1|root,COG2214@2|Bacteria	2|Bacteria	O	Heat shock protein DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DNAJ_related,DUF4388,DnaJ
CMS3_k127_3387528_5	351160.LRC556	3.185e-08	68.0	COG1520@1|root,arCOG02482@2157|Archaea,2XUI1@28890|Euryarchaeota	28890|Euryarchaeota	T	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
CMS3_k127_3387528_6	56780.SYN_00192	6.36e-05	55.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,42P5H@68525|delta/epsilon subdivisions,2WKAU@28221|Deltaproteobacteria,2MR1G@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Anaphase-promoting complex, cyclosome, subunit 3	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_4,TPR_6,TPR_7,TPR_8
CMS3_k127_3387528_4	243232.MJ_0714	1.873e-09	66.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota,23R2D@183939|Methanococci	183939|Methanococci	S	PFAM Roadblock LC7 family protein	-	GO:0001101,GO:0003674,GO:0005085,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0009719,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0019899,GO:0023051,GO:0023056,GO:0032006,GO:0032008,GO:0032947,GO:0042221,GO:0043200,GO:0044464,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051020,GO:0051716,GO:0065007,GO:0065009,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0098772,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
CMS3_k127_3387528_0	1379698.RBG1_1C00001G1745	3.335e-70	255.0	COG1100@1|root,COG1100@2|Bacteria,2NPDD@2323|unclassified Bacteria	2|Bacteria	K	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	mglA	GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,DUF697,MMR_HSR1
CMS3_k127_3387528_2	1379698.RBG1_1C00001G1744	8.597e-41	156.0	COG2018@1|root,COG2018@2|Bacteria,2NQXH@2323|unclassified Bacteria	2|Bacteria	S	Roadblock/LC7 domain	mglB	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
CMS3_k127_3387528_7	314278.NB231_16128	0.000346	52.0	COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria,1WWYG@135613|Chromatiales	135613|Chromatiales	E	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway	cysZ	-	-	ko:K06203	-	-	-	-	ko00000	-	-	-	DnaJ,EI24
CMS3_k127_3387528_1	485913.Krac_7836	4.864e-55	202.0	COG1960@1|root,COG1960@2|Bacteria,2G7JH@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_3392720_1	309807.SRU_0861	8.073e-65	242.0	COG0515@1|root,COG1196@1|root,COG0515@2|Bacteria,COG1196@2|Bacteria,4NSJA@976|Bacteroidetes,1FJ0Z@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	DKLT	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_3392720_0	1173026.Glo7428_0931	1.133e-88	299.0	COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_3401301_1	522306.CAP2UW1_0198	6.978e-136	440.0	COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,2VN83@28216|Betaproteobacteria	28216|Betaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
CMS3_k127_3401301_0	314285.KT71_03312	2.679e-268	835.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1J88Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
CMS3_k127_3424474_1	443143.GM18_0083	2.169e-80	284.0	COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,42S82@68525|delta/epsilon subdivisions,2WNUR@28221|Deltaproteobacteria,43TZW@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS3_k127_3424474_2	1399115.U719_13520	2.287e-22	113.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,4HC4H@91061|Bacilli	91061|Bacilli	D	Alpha beta	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
CMS3_k127_3424474_0	886293.Sinac_2812	0.0	1088.0	COG1413@1|root,COG2133@1|root,COG3828@1|root,COG1413@2|Bacteria,COG2133@2|Bacteria,COG3828@2|Bacteria,2IX57@203682|Planctomycetes	203682|Planctomycetes	C	Membrane-bound dehydrogenase domain	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	Cytochrom_C,ThuA
CMS3_k127_3424474_3	1160137.KB907307_gene4193	8.725e-12	74.0	COG0346@1|root,COG0346@2|Bacteria,2IM1B@201174|Actinobacteria,4G29E@85025|Nocardiaceae	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_3424474_4	314230.DSM3645_01931	1.014e-08	68.0	COG2304@1|root,COG2304@2|Bacteria,2IXE2@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
CMS3_k127_342475_1	1088721.NSU_4809	3.258e-59	227.0	COG0421@1|root,COG0421@2|Bacteria	2|Bacteria	E	spermidine synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
CMS3_k127_342475_0	883114.HMPREF9709_00214	2.984e-82	289.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,22H3H@1570339|Peptoniphilaceae	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
CMS3_k127_3427615_1	1003200.AXXA_06148	4.992e-71	264.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria	28216|Betaproteobacteria	T	response regulator	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_3427615_2	3075.A0A087SBE7	8.298e-19	102.0	KOG1151@1|root,KOG1151@2759|Eukaryota	2759|Eukaryota	H	protein serine/threonine kinase activity	-	-	2.7.11.1	ko:K08864	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF3148,Pkinase
CMS3_k127_3427615_0	1382356.JQMP01000004_gene566	1.552e-91	325.0	COG0497@1|root,COG0497@2|Bacteria,2G5V1@200795|Chloroflexi,27XPC@189775|Thermomicrobia	189775|Thermomicrobia	L	May be involved in recombinational repair of damaged DNA	-	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
CMS3_k127_3429414_1	1165841.SULAR_02993	1.198e-57	214.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,42PC4@68525|delta/epsilon subdivisions,2YP8E@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	radicals which are normally produced within the cells and which are toxic to biological systems	sodB	GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
CMS3_k127_3429414_0	1144275.COCOR_05654	7.393e-77	269.0	COG3380@1|root,COG3380@2|Bacteria,1R5C0@1224|Proteobacteria	1224|Proteobacteria	S	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050664,GO:0051287,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363	-	ko:K06955	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
CMS3_k127_3429414_2	65393.PCC7424_5221	2.476e-29	134.0	2BV8A@1|root,32QN0@2|Bacteria,1GDM3@1117|Cyanobacteria,3KJAR@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3430182_0	429009.Adeg_1824	7.812e-208	672.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,42EYE@68295|Thermoanaerobacterales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS3_k127_3430182_1	546267.NEIPOLOT_02542	5.593e-12	74.0	2DDXM@1|root,2ZJQE@2|Bacteria,1P5TP@1224|Proteobacteria,2W6B0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3432940_2	498761.HM1_1487	3.722e-90	312.0	COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia	186801|Clostridia	O	PFAM AIR synthase related protein	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
CMS3_k127_3432940_1	338966.Ppro_2778	4.169e-112	378.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2WJDQ@28221|Deltaproteobacteria,43U45@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	iAF987.Gmet_0117	HypD
CMS3_k127_3432940_7	1123288.SOV_3c01740	1.27e-16	85.0	COG0298@1|root,COG0298@2|Bacteria,1VFE0@1239|Firmicutes,4H5P1@909932|Negativicutes	909932|Negativicutes	O	Hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
CMS3_k127_3432940_0	326424.FRAAL1825	1.04e-164	546.0	COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
CMS3_k127_3432940_3	234267.Acid_6563	1.957e-55	207.0	COG0378@1|root,COG0378@2|Bacteria,3Y3AD@57723|Acidobacteria	57723|Acidobacteria	KO	Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
CMS3_k127_3432940_8	204669.Acid345_1556	3.022e-13	79.0	COG0375@1|root,COG0375@2|Bacteria	204669.Acid345_1556|-	S	nickel cation binding	-	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	-
CMS3_k127_3432940_6	572477.Alvin_1451	2.6e-26	118.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,1S4H2@1236|Gammaproteobacteria,1WYS9@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM Hydrogenase expression formation protein	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
CMS3_k127_3432940_5	768706.Desor_4118	2.909e-53	196.0	COG1969@1|root,COG1969@2|Bacteria,1UYHW@1239|Firmicutes,24D8Q@186801|Clostridia,2607B@186807|Peptococcaceae	186801|Clostridia	C	Ni Fe-hydrogenase, b-type cytochrome subunit	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
CMS3_k127_3432940_4	290512.Paes_0854	2.948e-54	192.0	COG0374@1|root,COG0374@2|Bacteria,1FDHI@1090|Chlorobi	1090|Chlorobi	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
CMS3_k127_3434891_1	1120948.KB903228_gene4811	5.315e-21	106.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4DXCK@85010|Pseudonocardiales	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_3434891_0	436229.JOEH01000009_gene4709	1.233e-23	110.0	COG0438@1|root,COG0438@2|Bacteria,2IA6D@201174|Actinobacteria,2NKZP@228398|Streptacidiphilus	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
CMS3_k127_3437541_2	1073999.BN137_247	7.301e-10	70.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0006970,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3437541_3	269797.Mbar_A1626	4.162e-09	70.0	COG1404@1|root,arCOG02512@1|root,arCOG00702@2157|Archaea,arCOG02512@2157|Archaea,2XTGN@28890|Euryarchaeota,2N9WH@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Calx-beta,Inhibitor_I9,Peptidase_S8
CMS3_k127_3437541_0	886293.Sinac_7396	5.363e-57	226.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
CMS3_k127_3437541_1	243090.RB9854	8.252e-29	125.0	COG0515@1|root,COG0515@2|Bacteria,2IWY8@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_3439119_0	1343740.M271_47735	1.996e-140	457.0	COG0624@1|root,COG0624@2|Bacteria,2GJDE@201174|Actinobacteria	201174|Actinobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS3_k127_3439119_1	886293.Sinac_2367	6.938e-07	56.0	COG0699@1|root,COG0699@2|Bacteria,2J0G9@203682|Planctomycetes	203682|Planctomycetes	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
CMS3_k127_3439314_3	314260.PB2503_11144	9.251e-38	164.0	COG1668@1|root,COG1668@2|Bacteria,1R62N@1224|Proteobacteria,2U1RZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CP	COG1668 ABC-type Na efflux pump, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
CMS3_k127_3439314_2	1047013.AQSP01000052_gene2600	3.682e-86	299.0	COG4152@1|root,COG4152@2|Bacteria,2NQE2@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4162)	natA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS3_k127_3439314_1	1121405.dsmv_0030	5.162e-177	569.0	COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria,2MJ7G@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
CMS3_k127_3439314_0	935948.KE386494_gene652	3.868e-183	586.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,42EYV@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
CMS3_k127_3441569_5	1232410.KI421424_gene1760	6.288e-55	198.0	COG2010@1|root,COG2010@2|Bacteria,1QYFZ@1224|Proteobacteria,43CC3@68525|delta/epsilon subdivisions,2WQTQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3441569_3	404589.Anae109_2407	7.028e-128	420.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,43AKQ@68525|delta/epsilon subdivisions,2X60P@28221|Deltaproteobacteria,2YWQF@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_4
CMS3_k127_3441569_0	404589.Anae109_2406	9.649e-171	547.0	COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42NUN@68525|delta/epsilon subdivisions,2WJHN@28221|Deltaproteobacteria,2YWI0@29|Myxococcales	28221|Deltaproteobacteria	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
CMS3_k127_3441569_6	880073.Calab_3408	2.057e-37	149.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Cytochrome_C554,DUF11,SLH
CMS3_k127_3441569_7	880073.Calab_3408	5.999e-32	134.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Cytochrome_C554,DUF11,SLH
CMS3_k127_3441569_1	1379698.RBG1_1C00001G0857	3.208e-140	465.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	1379698.RBG1_1C00001G0857|-	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3441569_4	1379698.RBG1_1C00001G0856	2.191e-88	303.0	COG0437@1|root,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
CMS3_k127_3441569_2	1379698.RBG1_1C00001G0855	8.087e-133	452.0	COG0243@1|root,COG0243@2|Bacteria,2NPRJ@2323|unclassified Bacteria	2|Bacteria	C	Molydopterin dinucleotide binding domain	qrcB	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS3_k127_3443098_0	1396141.BATP01000006_gene5459	2.433e-16	85.0	COG0346@1|root,COG0346@2|Bacteria,46T5V@74201|Verrucomicrobia,2IW80@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_3443098_1	1268622.AVS7_04322	1.544e-14	83.0	COG5553@1|root,COG5553@2|Bacteria,1R5RR@1224|Proteobacteria,2VQ9W@28216|Betaproteobacteria,4AGI1@80864|Comamonadaceae	28216|Betaproteobacteria	C	metal-dependent enzyme of the double-stranded beta helix superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CDO_I
CMS3_k127_3443098_2	706439.HMPREF9057_03099	5.366e-08	67.0	COG1595@1|root,COG1595@2|Bacteria,2GP9D@201174|Actinobacteria,4D4ET@85005|Actinomycetales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigK	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0010565,GO:0016020,GO:0019216,GO:0019217,GO:0019222,GO:0030312,GO:0031323,GO:0044464,GO:0050789,GO:0050794,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_344646_3	1232410.KI421413_gene667	1.827e-60	218.0	COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,42TAU@68525|delta/epsilon subdivisions,2WPD6@28221|Deltaproteobacteria,43UN9@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS3_k127_344646_0	314230.DSM3645_18751	7.124e-101	354.0	COG0608@1|root,COG0608@2|Bacteria,2IXVB@203682|Planctomycetes	203682|Planctomycetes	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
CMS3_k127_344646_1	1125863.JAFN01000001_gene282	9.971e-99	339.0	COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
CMS3_k127_344646_2	868595.Desca_1968	5.347e-91	309.0	COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,260DU@186807|Peptococcaceae	186801|Clostridia	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
CMS3_k127_344646_4	1453501.JELR01000002_gene877	1.733e-53	201.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,467AM@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
CMS3_k127_344646_5	240015.ACP_0207	6.835e-40	153.0	COG1765@1|root,COG1765@2|Bacteria,3Y7VV@57723|Acidobacteria,2JN4F@204432|Acidobacteriia	204432|Acidobacteriia	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
CMS3_k127_3446512_2	696747.NIES39_C05180	4.649e-61	223.0	COG1520@1|root,COG2931@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,1GQUQ@1117|Cyanobacteria,1HBB3@1150|Oscillatoriales	1117|Cyanobacteria	G	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind
CMS3_k127_3446512_1	521674.Plim_3506	7.159e-140	459.0	COG1520@1|root,COG1520@2|Bacteria,2IY7A@203682|Planctomycetes	203682|Planctomycetes	S	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS3_k127_3446512_0	234267.Acid_7735	1.588e-220	694.0	COG1032@1|root,COG1032@2|Bacteria,3Y4FB@57723|Acidobacteria	57723|Acidobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS3_k127_3469890_0	886293.Sinac_3627	3.673e-58	217.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_8,WD40
CMS3_k127_3469890_1	926566.Terro_0522	1.621e-06	58.0	COG1595@1|root,COG1595@2|Bacteria,3Y45G@57723|Acidobacteria,2JIQI@204432|Acidobacteriia	2|Bacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_3469890_2	1144275.COCOR_03178	2.499e-05	52.0	COG0823@1|root,COG0823@2|Bacteria,1QXUF@1224|Proteobacteria,43CK6@68525|delta/epsilon subdivisions,2X7UM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	HYR
CMS3_k127_3476629_1	1123274.KB899407_gene236	7.021e-43	162.0	COG0252@1|root,COG0252@2|Bacteria	2|Bacteria	EJ	asparaginase activity	aspG	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
CMS3_k127_3476629_0	1089551.KE386572_gene3673	2.203e-94	319.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2TT0H@28211|Alphaproteobacteria,4BR33@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
CMS3_k127_3482738_2	1254432.SCE1572_52290	0.0004925	53.0	COG4932@1|root,COG4932@2|Bacteria,1PYE0@1224|Proteobacteria,43E3U@68525|delta/epsilon subdivisions,2X97I@28221|Deltaproteobacteria,2Z2E0@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_3482738_0	631362.Thi970DRAFT_00635	3.762e-76	259.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,1S25K@1236|Gammaproteobacteria,1X0M6@135613|Chromatiales	135613|Chromatiales	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
CMS3_k127_3482738_1	1169161.KB897724_gene4907	2.591e-12	78.0	COG3250@1|root,COG3250@2|Bacteria,2GMAT@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
CMS3_k127_3490984_1	1121875.KB907549_gene1716	3.037e-11	68.0	2DZVD@1|root,32VJZ@2|Bacteria,4NUB2@976|Bacteroidetes,1I482@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ydhR
CMS3_k127_3490984_0	378806.STAUR_6026	1.433e-11	75.0	COG3794@1|root,COG3794@2|Bacteria,1Q2EH@1224|Proteobacteria,43807@68525|delta/epsilon subdivisions,2X3A8@28221|Deltaproteobacteria,2YV38@29|Myxococcales	28221|Deltaproteobacteria	C	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_3498865_2	91464.S7335_997	0.0002561	53.0	29BRG@1|root,2ZYPV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3498865_0	344747.PM8797T_17227	4.161e-224	705.0	COG4102@1|root,COG4102@2|Bacteria,2J4YY@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_3498865_1	344747.PM8797T_17222	5.069e-96	319.0	COG2010@1|root,COG2010@2|Bacteria,2IY86@203682|Planctomycetes	203682|Planctomycetes	C	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PSCyt1,PSCyt2,PSD1
CMS3_k127_3511611_0	391625.PPSIR1_36252	6.198e-126	410.0	COG1024@1|root,COG1024@2|Bacteria,1N817@1224|Proteobacteria	1224|Proteobacteria	I	Enoyl-CoA hydratase	boxC	-	4.1.2.44	ko:K15513	ko00362,map00362	-	R09556	RC03426	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS3_k127_3511611_2	316055.RPE_0475	7.887e-54	199.0	COG0703@1|root,COG1476@1|root,COG0703@2|Bacteria,COG1476@2|Bacteria,1MX66@1224|Proteobacteria,2TQWU@28211|Alphaproteobacteria,3JUIK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EK	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	-	ko:K15546	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,HTH_31,SKI
CMS3_k127_3511611_1	1408473.JHXO01000010_gene3609	2.347e-104	351.0	COG1171@1|root,COG1171@2|Bacteria,4NEY2@976|Bacteroidetes,2FX64@200643|Bacteroidia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_3511611_3	370438.PTH_2559	7.383e-20	96.0	COG4636@1|root,COG4636@2|Bacteria,1V60G@1239|Firmicutes,24HUW@186801|Clostridia,261ZJ@186807|Peptococcaceae	186801|Clostridia	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
CMS3_k127_3513695_0	595460.RRSWK_00370	1.793e-101	340.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS3_k127_3513695_1	518766.Rmar_2169	4.569e-86	293.0	COG0421@1|root,COG0421@2|Bacteria,4PME3@976|Bacteroidetes	976|Bacteroidetes	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
CMS3_k127_3513695_3	343509.SG1630	1.074e-14	85.0	COG2062@1|root,COG2062@2|Bacteria,1NAAE@1224|Proteobacteria,1SD0B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	phosphohistidine phosphatase	sixA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:1901564	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
CMS3_k127_3513695_2	742725.HMPREF9450_00468	4.387e-33	133.0	COG0010@1|root,COG0010@2|Bacteria,4NE01@976|Bacteroidetes,2FSS3@200643|Bacteroidia,22UZI@171550|Rikenellaceae	976|Bacteroidetes	E	Arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
CMS3_k127_351458_2	877418.ATWV01000016_gene2792	0.0001656	53.0	COG1366@1|root,COG1366@2|Bacteria,2J9G3@203691|Spirochaetes	203691|Spirochaetes	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS
CMS3_k127_351458_1	240015.ACP_1964	7.388e-28	128.0	COG2208@1|root,COG2208@2|Bacteria,3Y4A2@57723|Acidobacteria,2JJ6J@204432|Acidobacteriia	204432|Acidobacteriia	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_3,SpoIIE
CMS3_k127_351458_0	1122962.AULH01000009_gene3774	2.3e-80	288.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,2TSQH@28211|Alphaproteobacteria,36XG6@31993|Methylocystaceae	28211|Alphaproteobacteria	F	Amidohydrolase family	pyrC1	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
CMS3_k127_3515192_3	1229780.BN381_610011	0.0007219	46.0	COG2801@1|root,COG2801@2|Bacteria,2GN25@201174|Actinobacteria	201174|Actinobacteria	L	Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve_3
CMS3_k127_3515192_2	1267535.KB906767_gene2042	2.689e-17	87.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,LZ_Tnp_IS481,rve_3
CMS3_k127_3515192_0	1267533.KB906733_gene3472	8.743e-92	337.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,TPR_8
CMS3_k127_3515192_1	379066.GAU_3840	2.038e-38	148.0	COG1595@1|root,COG1595@2|Bacteria,1ZV2F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS3_k127_3518236_0	575540.Isop_1688	4.51e-87	305.0	COG0323@1|root,COG0323@2|Bacteria,2IXI2@203682|Planctomycetes	203682|Planctomycetes	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
CMS3_k127_3518236_4	1499967.BAYZ01000182_gene4417	2.246e-08	66.0	COG1466@1|root,COG1466@2|Bacteria,2NPN5@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta,DNA_pol3_gamma3
CMS3_k127_3518236_1	984262.SGRA_1441	9.968e-75	269.0	COG0382@1|root,COG0382@2|Bacteria,4NEE3@976|Bacteroidetes,1IP3B@117747|Sphingobacteriia	976|Bacteroidetes	H	4-hydroxybenzoate polyprenyltransferase	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
CMS3_k127_3518236_3	1158756.AQXQ01000012_gene1790	1.331e-54	198.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1WWQJ@135613|Chromatiales	135613|Chromatiales	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
CMS3_k127_3518236_2	1123508.JH636446_gene6237	2.497e-64	229.0	COG0500@1|root,COG2226@2|Bacteria,2IYWE@203682|Planctomycetes	203682|Planctomycetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
CMS3_k127_3521881_4	443143.GM18_1659	1.181e-06	61.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_3,DUF4347,HemolysinCabind,Phosphoesterase,VCBS,fn3
CMS3_k127_3521881_5	1382356.JQMP01000001_gene1014	0.0001785	54.0	COG0457@1|root,COG0457@2|Bacteria,2G770@200795|Chloroflexi,27Y28@189775|Thermomicrobia	189775|Thermomicrobia	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
CMS3_k127_3521881_3	502025.Hoch_6594	1.831e-58	213.0	COG2426@1|root,COG2426@2|Bacteria,1PB7N@1224|Proteobacteria,432PT@68525|delta/epsilon subdivisions,2WYBP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
CMS3_k127_3521881_1	696369.KI912183_gene2684	1.5e-94	320.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,260QV@186807|Peptococcaceae	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CMS3_k127_3521881_2	1195236.CTER_4689	3.85e-69	248.0	COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,3WIER@541000|Ruminococcaceae	186801|Clostridia	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
CMS3_k127_3521881_0	886293.Sinac_6803	5.242e-115	380.0	COG0505@1|root,COG0505@2|Bacteria,2IWSY@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
CMS3_k127_3525831_2	596151.DesfrDRAFT_3368	9.938e-35	149.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2M7SW@213115|Desulfovibrionales	28221|Deltaproteobacteria	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS3_k127_3525831_3	864702.OsccyDRAFT_2289	2.321e-21	106.0	COG2805@1|root,COG2805@2|Bacteria,1GBXW@1117|Cyanobacteria,1HED6@1150|Oscillatoriales	1117|Cyanobacteria	NU	Type II/IV secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
CMS3_k127_3525831_5	1536772.R70723_29180	3.44e-05	56.0	COG5662@1|root,COG5662@2|Bacteria,1V6C7@1239|Firmicutes,4HJS2@91061|Bacilli,26UNK@186822|Paenibacillaceae	91061|Bacilli	K	Anti-sigma W factor	rsiW	-	-	-	-	-	-	-	-	-	-	-	Bactofilin,zf-HC2
CMS3_k127_3525831_4	309807.SRU_1707	4.02e-21	101.0	COG1595@1|root,COG1595@2|Bacteria,4PF4G@976|Bacteroidetes,1FK4D@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3525831_0	880073.Calab_1440	2.825e-39	156.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	mpaA	GO:0000270,GO:0003674,GO:0003824,GO:0004040,GO:0004180,GO:0004181,GO:0005488,GO:0006022,GO:0006026,GO:0006027,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009050,GO:0009056,GO:0009057,GO:0009253,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0030203,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0046872,GO:0046914,GO:0061473,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	-	ko:K14054	-	-	-	-	ko00000	-	-	iEC55989_1330.EC55989_1490,iECO103_1326.ECO103_1491	Peptidase_M14
CMS3_k127_3525831_1	1249627.D779_0549	3.021e-35	150.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1WWF8@135613|Chromatiales	135613|Chromatiales	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K01081,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
CMS3_k127_3528034_2	717606.PaecuDRAFT_2033	3.927e-31	136.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,1UKER@1239|Firmicutes,4HFP1@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
CMS3_k127_3528034_0	717774.Marme_0332	7.787e-49	197.0	COG0697@1|root,COG0697@2|Bacteria,1RDF6@1224|Proteobacteria,1S3F3@1236|Gammaproteobacteria,1XS9B@135619|Oceanospirillales	135619|Oceanospirillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_3528034_1	1122939.ATUD01000001_gene577	5.607e-39	165.0	COG1520@1|root,COG1520@2|Bacteria,2H3K4@201174|Actinobacteria,4CRJK@84995|Rubrobacteria	84995|Rubrobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3533103_0	1142394.PSMK_01210	1.054e-22	99.0	COG0188@1|root,COG0188@2|Bacteria,2IXMT@203682|Planctomycetes	203682|Planctomycetes	L	COG0188 Type IIA topoisomerase (DNA gyrase topo II topoisomerase IV) A subunit	-	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CMS3_k127_3534390_0	926566.Terro_3516	1.263e-57	208.0	COG2355@1|root,COG2355@2|Bacteria,3Y39A@57723|Acidobacteria,2JI1H@204432|Acidobacteriia	57723|Acidobacteria	E	PFAM Peptidase M19, renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
CMS3_k127_353771_0	215803.DB30_5770	7.637e-52	211.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,42P8D@68525|delta/epsilon subdivisions,2WMH1@28221|Deltaproteobacteria,2YWWP@29|Myxococcales	28221|Deltaproteobacteria	KLT	COG0515 Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase,Pkinase_Tyr,WD40
CMS3_k127_3538901_0	1121447.JONL01000009_gene2656	6.566e-69	259.0	COG3868@1|root,COG3868@2|Bacteria,1MXYK@1224|Proteobacteria,42PSV@68525|delta/epsilon subdivisions,2WMYA@28221|Deltaproteobacteria,2M9WK@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM TM1410 hypothetical-related protein	-	-	-	ko:K21006	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	Glyco_hydro_114
CMS3_k127_3538901_1	483219.LILAB_32280	0.0004837	53.0	COG0457@1|root,COG2956@1|root,COG3118@1|root,COG0457@2|Bacteria,COG2956@2|Bacteria,COG3118@2|Bacteria,1MVIW@1224|Proteobacteria,437VP@68525|delta/epsilon subdivisions,2WWNT@28221|Deltaproteobacteria,2YUC4@29|Myxococcales	28221|Deltaproteobacteria	G	repeat protein	agmK	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_16,TPR_19,TPR_6,TPR_7,TPR_8
CMS3_k127_3545473_1	344747.PM8797T_18736	7.377e-43	165.0	COG1312@1|root,COG1312@2|Bacteria,2IXAA@203682|Planctomycetes	203682|Planctomycetes	G	D-mannonate dehydratase (UxuA)	-	-	-	-	-	-	-	-	-	-	-	-	UxuA
CMS3_k127_3545473_0	251229.Chro_2164	1.542e-61	220.0	COG4221@1|root,COG4221@2|Bacteria,1G156@1117|Cyanobacteria,3VIZ0@52604|Pleurocapsales	1117|Cyanobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_3545473_2	290318.Cvib_1366	3.243e-18	100.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS3_k127_3546582_1	1304880.JAGB01000001_gene680	4.017e-53	215.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS3_k127_3546582_0	290397.Adeh_1417	8.182e-223	702.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42PMK@68525|delta/epsilon subdivisions,2X5G7@28221|Deltaproteobacteria,2Z35F@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_3559822_2	344747.PM8797T_27090	1.943e-14	84.0	COG1413@1|root,COG1413@2|Bacteria,2IYY2@203682|Planctomycetes	203682|Planctomycetes	C	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,Prenyltrans
CMS3_k127_3559822_0	391625.PPSIR1_36914	3.906e-78	284.0	COG0434@1|root,COG0434@2|Bacteria,1PI3K@1224|Proteobacteria,435DY@68525|delta/epsilon subdivisions,2X98F@28221|Deltaproteobacteria,2Z2KI@29|Myxococcales	28221|Deltaproteobacteria	S	BtpA family	-	-	-	ko:K06971	-	-	-	-	ko00000	-	-	-	BtpA
CMS3_k127_3559822_1	1286093.C266_17941	1.648e-46	180.0	COG0457@1|root,COG0457@2|Bacteria	1286093.C266_17941|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3567022_2	1198232.CYCME_1447	9.89e-81	280.0	COG1216@1|root,COG1216@2|Bacteria,1RHVX@1224|Proteobacteria	1224|Proteobacteria	S	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_3567022_3	1318628.MARLIPOL_06099	9.287e-56	210.0	COG0421@1|root,COG0421@2|Bacteria,1QUUH@1224|Proteobacteria,1T268@1236|Gammaproteobacteria,466KQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG0421 Spermidine synthase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3567022_4	472759.Nhal_1641	7.485e-12	75.0	28NM7@1|root,2ZBMT@2|Bacteria,1R9Y9@1224|Proteobacteria,1S227@1236|Gammaproteobacteria,1X0Q2@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2959)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2959
CMS3_k127_3567022_0	880073.Calab_3330	7.976e-96	344.0	COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,2NS2I@2323|unclassified Bacteria	2|Bacteria	O	Pyridine nucleotide-disulphide oxidoreductase	trxB_2	-	1.18.1.2,1.19.1.1,1.8.1.9	ko:K00384,ko:K21567	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,Pyr_redox_3
CMS3_k127_3567022_1	204669.Acid345_0472	1.435e-94	337.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII,Cytochrom_c3_2,Cytochrome_C7
CMS3_k127_35672_0	1267535.KB906767_gene3320	7.742e-68	234.0	COG4993@1|root,COG4993@2|Bacteria,3Y639@57723|Acidobacteria	57723|Acidobacteria	G	PQQ enzyme repeat	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ
CMS3_k127_35672_1	391596.PBAL39_23752	5.912e-54	207.0	2EBZK@1|root,335YW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_35672_2	761193.Runsl_2439	7.374e-11	64.0	COG1073@1|root,COG1073@2|Bacteria,4NI6C@976|Bacteroidetes,47N3Z@768503|Cytophagia	976|Bacteroidetes	S	Acetyl xylan esterase	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
CMS3_k127_3570557_0	344747.PM8797T_27145	8.895e-265	844.0	COG0841@1|root,COG0841@2|Bacteria,2IYRV@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS3_k127_3570557_3	1122613.ATUP01000001_gene2387	2.586e-26	113.0	COG0845@1|root,COG0845@2|Bacteria,1NJDF@1224|Proteobacteria,2TSZA@28211|Alphaproteobacteria,43XXZ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS3_k127_3570557_2	344747.PM8797T_27140	1.362e-34	144.0	COG0845@1|root,COG0845@2|Bacteria,2IZSE@203682|Planctomycetes	203682|Planctomycetes	M	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
CMS3_k127_3570557_1	530564.Psta_1008	4.49e-45	170.0	COG1309@1|root,COG1309@2|Bacteria,2IZ6X@203682|Planctomycetes	203682|Planctomycetes	K	Bacterial regulatory proteins, tetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_3570934_0	1219084.AP014508_gene1943	2.482e-69	245.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	MA20_02630	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_3570934_1	197221.22296018	6.266e-66	256.0	COG5505@1|root,COG5505@2|Bacteria,1G9X6@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF819
CMS3_k127_3570934_2	8479.XP_008167801.1	4.721e-11	76.0	COG2304@1|root,2QPS2@2759|Eukaryota,38C6V@33154|Opisthokonta,3BE0X@33208|Metazoa,3CW49@33213|Bilateria,48A1Z@7711|Chordata,49623@7742|Vertebrata,4CFS6@8459|Testudines	33208|Metazoa	S	Inter-alpha-trypsin inhibitor heavy chain	ITIH2	GO:0003674,GO:0004857,GO:0004866,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010466,GO:0010605,GO:0010951,GO:0012505,GO:0019222,GO:0019538,GO:0030162,GO:0030234,GO:0030414,GO:0031323,GO:0031324,GO:0031974,GO:0032268,GO:0032269,GO:0036211,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043687,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0098772,GO:1901564	-	ko:K19015	-	-	-	-	ko00000,ko00536	-	-	-	ITI_HC_C,VIT,VWA
CMS3_k127_3570934_3	925409.KI911562_gene1302	2.409e-09	67.0	COG1956@1|root,COG1956@2|Bacteria,4NM6D@976|Bacteroidetes,1IS2U@117747|Sphingobacteriia	976|Bacteroidetes	T	GAF domain-containing protein	msrC	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF,GAF_2
CMS3_k127_3572022_0	861299.J421_1876	4.198e-142	476.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
CMS3_k127_3572022_1	1379270.AUXF01000007_gene997	9.272e-73	252.0	COG2819@1|root,COG2819@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS3_k127_3576223_5	1089551.KE386572_gene1342	2.209e-64	221.0	COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,2TS7U@28211|Alphaproteobacteria,4BP7I@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	JM	Nucleotidyl transferase	rfbF	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
CMS3_k127_3576223_0	1089551.KE386572_gene1344	3.871e-161	520.0	COG0500@1|root,COG0500@2|Bacteria,1MVD1@1224|Proteobacteria,2TUKG@28211|Alphaproteobacteria,4BQF7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	C-methyltransferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
CMS3_k127_3576223_1	383372.Rcas_3091	4.029e-144	467.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.294,2.1.1.79,2.7.1.181	ko:K00574,ko:K18827	-	-	R10657,R10658	RC00002,RC00003,RC00078,RC03220	ko00000,ko01000,ko01005	-	-	-	MethyTransf_Reg,Methyltransf_14,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS3_k127_3576223_3	383372.Rcas_3088	4.304e-87	306.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K20444	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Acyltransferase,MMPL,Methyltransf_13,Methyltransf_14,Methyltransf_23,Methyltransf_31
CMS3_k127_3576223_2	869210.Marky_0739	1.807e-141	456.0	COG0451@1|root,COG0451@2|Bacteria,1WMCY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM NAD dependent epimerase dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS3_k127_3576223_4	706587.Desti_0940	1.212e-73	261.0	COG0438@1|root,COG0438@2|Bacteria,1PERD@1224|Proteobacteria,42VK8@68525|delta/epsilon subdivisions,2WSBY@28221|Deltaproteobacteria,2MRQI@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_3579210_1	96561.Dole_1273	1.028e-08	64.0	COG0457@1|root,COG0457@2|Bacteria,1RKQQ@1224|Proteobacteria,42T9T@68525|delta/epsilon subdivisions,2WPQ0@28221|Deltaproteobacteria,2MN67@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_16,TPR_2,TPR_8
CMS3_k127_3579210_0	1267580.AF6_0716	3.484e-200	642.0	COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,4HACD@91061|Bacilli,21WRR@150247|Anoxybacillus	91061|Bacilli	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
CMS3_k127_3580132_1	1536769.P40081_26985	3.261e-07	62.0	COG1404@1|root,COG4099@1|root,COG1404@2|Bacteria,COG4099@2|Bacteria,1V3AJ@1239|Firmicutes,4HHP0@91061|Bacilli,26V21@186822|Paenibacillaceae	91061|Bacilli	M	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,CHB_HEX_C_1,Esterase,Esterase_phd,Peptidase_S9,SLH
CMS3_k127_3580132_0	1380391.JIAS01000012_gene4472	3.377e-36	151.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,2JPE1@204441|Rhodospirillales	204441|Rhodospirillales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
CMS3_k127_3581075_2	1047013.AQSP01000110_gene79	4.368e-45	186.0	COG0733@1|root,COG0733@2|Bacteria,2NQIH@2323|unclassified Bacteria	2|Bacteria	S	Sodium:neurotransmitter symporter family	CP_0468	-	-	ko:K03308,ko:K03466	-	-	-	-	ko00000,ko03036	2.A.22.4,2.A.22.5,3.A.12	-	-	SNF
CMS3_k127_3581075_0	1382306.JNIM01000001_gene3396	2.937e-243	762.0	COG2987@1|root,COG2987@2|Bacteria,2G5PQ@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
CMS3_k127_3581075_1	555088.DealDRAFT_1745	2.645e-60	214.0	COG1704@1|root,COG1704@2|Bacteria,1V3Z0@1239|Firmicutes,24IH4@186801|Clostridia,42KPY@68298|Syntrophomonadaceae	186801|Clostridia	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
CMS3_k127_3591813_8	314230.DSM3645_18951	5.837e-21	103.0	COG5029@1|root,COG5029@2|Bacteria,2IYVM@203682|Planctomycetes	203682|Planctomycetes	O	beta-subunit of geranylgeranyltransferase or farnesyltransferase	-	-	2.5.1.60	ko:K05956	-	-	-	-	ko00000,ko01000,ko01006,ko04131	-	-	-	Prenyltrans
CMS3_k127_3591813_0	497964.CfE428DRAFT_0155	2.816e-195	640.0	COG0142@1|root,COG1852@1|root,COG0142@2|Bacteria,COG1852@2|Bacteria,46TEA@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Protein of unknown function DUF116	-	-	-	-	-	-	-	-	-	-	-	-	DUF116,polyprenyl_synt
CMS3_k127_3591813_2	1123242.JH636435_gene1438	1.234e-164	528.0	COG0535@1|root,COG0535@2|Bacteria,2IX8N@203682|Planctomycetes	203682|Planctomycetes	S	enzyme of the MoaA nifB pqqE family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS3_k127_3591813_5	497964.CfE428DRAFT_6362	2.05e-83	286.0	COG1146@1|root,COG1146@2|Bacteria,46TI2@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3591813_7	497964.CfE428DRAFT_6361	3.546e-29	134.0	2FICZ@1|root,34A57@2|Bacteria,46W7Z@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3591813_3	1403819.BATR01000066_gene1952	2.873e-122	410.0	COG0523@1|root,COG0523@2|Bacteria,46URF@74201|Verrucomicrobia	74201|Verrucomicrobia	S	SRP54-type protein, GTPase domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
CMS3_k127_3591813_6	497964.CfE428DRAFT_6360	1.553e-38	148.0	COG0509@1|root,COG0509@2|Bacteria,46WCE@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	GCV_H
CMS3_k127_3591813_1	240016.ABIZ01000001_gene1448	1.174e-187	618.0	COG1520@1|root,COG1520@2|Bacteria,46UUP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_3591813_4	497964.CfE428DRAFT_5031	1.739e-84	287.0	COG1520@1|root,COG1520@2|Bacteria,46U89@74201|Verrucomicrobia	2|Bacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS3_k127_359730_2	502025.Hoch_5627	3.53e-38	153.0	COG1716@1|root,COG1716@2|Bacteria,1NEW5@1224|Proteobacteria,42VUF@68525|delta/epsilon subdivisions,2WRV9@28221|Deltaproteobacteria,2YV34@29|Myxococcales	28221|Deltaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,TonB_C,Yop-YscD_cpl
CMS3_k127_359730_1	448385.sce2916	3e-53	207.0	COG0457@1|root,COG0457@2|Bacteria,1NFC8@1224|Proteobacteria,42VYT@68525|delta/epsilon subdivisions,2WRFT@28221|Deltaproteobacteria,2Z1XW@29|Myxococcales	28221|Deltaproteobacteria	S	adventurous gliding protein T	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_10,TPR_16,TPR_19,TPR_2,TPR_8
CMS3_k127_359730_0	1254432.SCE1572_17770	1.753e-179	608.0	COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,42TQ9@68525|delta/epsilon subdivisions,2WR3B@28221|Deltaproteobacteria,2YUXH@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
CMS3_k127_359730_3	1254432.SCE1572_17765	4.42e-10	61.0	COG0457@1|root,COG0457@2|Bacteria,1P0DI@1224|Proteobacteria,431RN@68525|delta/epsilon subdivisions,2WWCP@28221|Deltaproteobacteria,2Z3IU@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3598704_0	344747.PM8797T_16178	2.125e-183	578.0	COG3119@1|root,COG3119@2|Bacteria,2J1RU@203682|Planctomycetes	203682|Planctomycetes	P	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_3598704_1	215803.DB30_1551	1.092e-60	226.0	2A50E@1|root,30TNM@2|Bacteria,1PDKQ@1224|Proteobacteria,4340N@68525|delta/epsilon subdivisions,2X4G0@28221|Deltaproteobacteria,2YYY5@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3600207_2	378806.STAUR_7090	6.252e-10	72.0	COG0402@1|root,COG2374@1|root,COG0402@2|Bacteria,COG2374@2|Bacteria,1NFUA@1224|Proteobacteria,433MB@68525|delta/epsilon subdivisions,2WXJF@28221|Deltaproteobacteria,2YUGP@29|Myxococcales	28221|Deltaproteobacteria	F	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,DUF4215,LTD,TSP_3
CMS3_k127_3600207_3	1121468.AUBR01000020_gene2852	9.947e-08	64.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,42EX6@68295|Thermoanaerobacterales	186801|Clostridia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS3_k127_3600207_4	1345697.M493_13865	0.0005941	48.0	COG1807@1|root,COG1807@2|Bacteria,1TR0R@1239|Firmicutes,4HBI2@91061|Bacilli,1WEN5@129337|Geobacillus	91061|Bacilli	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_3600207_0	1229276.DI53_0434	2.091e-28	124.0	COG1435@1|root,COG1435@2|Bacteria,4NE5R@976|Bacteroidetes,1IS2H@117747|Sphingobacteriia	976|Bacteroidetes	F	thymidine kinase	tdk	GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
CMS3_k127_3600207_1	1121948.AUAC01000006_gene589	1.369e-17	85.0	COG1235@1|root,COG1235@2|Bacteria,1PVWC@1224|Proteobacteria,2V746@28211|Alphaproteobacteria,43Z2A@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	ko:K06136	-	-	-	-	ko00000	-	-	-	Lactamase_B_2
CMS3_k127_3603586_0	234267.Acid_7369	2.39e-119	390.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria	57723|Acidobacteria	S	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS3_k127_3603586_1	1379698.RBG1_1C00001G1377	1.489e-24	121.0	COG4409@1|root,COG4409@2|Bacteria,2NRD7@2323|unclassified Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase
CMS3_k127_3604970_0	1042163.BRLA_c000650	1.041e-31	137.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,4HA4R@91061|Bacilli,26QVV@186822|Paenibacillaceae	91061|Bacilli	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
CMS3_k127_3604970_2	67315.JOBD01000050_gene4940	1.231e-10	73.0	COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria	201174|Actinobacteria	KLT	Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine	-	-	-	ko:K20333	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	FGE-sulfatase
CMS3_k127_3604970_1	404589.Anae109_2842	2.207e-20	99.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,42T2J@68525|delta/epsilon subdivisions,2WPPV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	PFAM OmpA MotB domain protein	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
CMS3_k127_3607676_1	391625.PPSIR1_20349	1.484e-16	93.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,PDZ_2
CMS3_k127_3607676_0	595460.RRSWK_05386	1.216e-93	319.0	COG1913@1|root,COG1913@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
CMS3_k127_3611042_1	357808.RoseRS_4272	4.199e-22	108.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,2G88I@200795|Chloroflexi,3780V@32061|Chloroflexia	32061|Chloroflexia	U	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3611042_2	644801.Psest_2051	3.133e-14	85.0	COG0349@1|root,COG4273@1|root,COG0349@2|Bacteria,COG4273@2|Bacteria,1RFXW@1224|Proteobacteria,1S548@1236|Gammaproteobacteria,1Z10X@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	3'-5' exonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_A_exo1
CMS3_k127_3611042_0	1123242.JH636435_gene1540	7.136e-143	474.0	COG1520@1|root,COG1520@2|Bacteria,2IX67@203682|Planctomycetes	203682|Planctomycetes	S	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS3_k127_3611042_6	1121121.KB894312_gene3208	0.0005539	47.0	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes	1239|Firmicutes	K	Transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS3_k127_3611042_5	1123508.JH636439_gene992	0.0003189	45.0	COG2706@1|root,COG2931@1|root,COG2982@1|root,COG4412@1|root,COG2706@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	CARDB,Malectin,Peptidase_M30,VCBS
CMS3_k127_3611042_4	1121935.AQXX01000098_gene1662	2.281e-06	53.0	COG3386@1|root,COG3391@1|root,COG4625@1|root,COG4733@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,COG4625@2|Bacteria,COG4733@2|Bacteria,1R2J4@1224|Proteobacteria,1T5QW@1236|Gammaproteobacteria,1XQGX@135619|Oceanospirillales	135619|Oceanospirillales	G	Calx-beta domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
CMS3_k127_3611042_3	404380.Gbem_1798	1.799e-06	60.0	COG1404@1|root,COG4932@1|root,COG1404@2|Bacteria,COG4932@2|Bacteria,1MU3S@1224|Proteobacteria	1224|Proteobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,fn3
CMS3_k127_3623221_4	1089552.KI911559_gene2991	4.185e-33	134.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,2JS9R@204441|Rhodospirillales	204441|Rhodospirillales	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
CMS3_k127_3623221_0	247490.KSU1_C1236	1.925e-107	359.0	COG0202@1|root,COG0202@2|Bacteria,2IXPQ@203682|Planctomycetes	203682|Planctomycetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
CMS3_k127_3623221_1	264732.Moth_2432	1.298e-65	236.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,42ENH@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
CMS3_k127_3623221_2	756272.Plabr_2080	1.129e-50	184.0	COG0100@1|root,COG0100@2|Bacteria,2IZCP@203682|Planctomycetes	203682|Planctomycetes	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
CMS3_k127_3623221_3	1111479.AXAR01000008_gene2334	3.528e-41	163.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,4HGX6@91061|Bacilli,278EH@186823|Alicyclobacillaceae	91061|Bacilli	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
CMS3_k127_3623221_5	247490.KSU1_C1231	1.423e-12	71.0	COG0257@1|root,COG0257@2|Bacteria,2J1IK@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
CMS3_k127_3625492_0	1288963.ADIS_1386	4.248e-124	419.0	28HHT@1|root,2Z7TE@2|Bacteria,4NIHS@976|Bacteroidetes,47MAA@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3625492_2	1208321.D104_08320	1.59e-11	75.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS3_k127_3625492_3	156978.CIMIT_00615	1.509e-09	72.0	COG4932@1|root,COG4932@2|Bacteria,2HQGK@201174|Actinobacteria,22Q6J@1653|Corynebacteriaceae	201174|Actinobacteria	M	SdrD B-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
CMS3_k127_3625492_1	1384056.N787_06630	5.372e-45	169.0	COG2197@1|root,COG2267@1|root,COG2197@2|Bacteria,COG2267@2|Bacteria,1QYHB@1224|Proteobacteria,1T613@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
CMS3_k127_363019_0	1499967.BAYZ01000167_gene6760	5.535e-106	359.0	COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF_2,HTH_8,PAS_9,Response_reg,Sigma54_activat
CMS3_k127_363019_3	485917.Phep_1253	1.834e-71	268.0	COG4409@1|root,COG4409@2|Bacteria,4P1PN@976|Bacteroidetes	976|Bacteroidetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
CMS3_k127_363019_1	1123248.KB893381_gene986	1.525e-95	340.0	COG1073@1|root,COG1073@2|Bacteria,4NWMR@976|Bacteroidetes,1IU11@117747|Sphingobacteriia	976|Bacteroidetes	S	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,DLH
CMS3_k127_363019_2	240016.ABIZ01000001_gene1539	2.835e-76	281.0	COG1520@1|root,COG1520@2|Bacteria,46TV4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_363019_4	1297742.A176_04293	2.77e-25	123.0	COG4977@1|root,COG4977@2|Bacteria,1QUTN@1224|Proteobacteria,43CIK@68525|delta/epsilon subdivisions,2WQ8R@28221|Deltaproteobacteria,2Z1G2@29|Myxococcales	28221|Deltaproteobacteria	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
CMS3_k127_3632014_1	1379270.AUXF01000001_gene2621	4.154e-08	61.0	COG0226@1|root,COG0226@2|Bacteria	2|Bacteria	P	phosphate ion binding	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	Big_5,PBP_like_2
CMS3_k127_3632014_0	382464.ABSI01000011_gene2465	9.456e-52	204.0	COG2273@1|root,COG3291@1|root,COG5297@1|root,COG2273@2|Bacteria,COG3291@2|Bacteria,COG5297@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase family 6	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CBM_4_9,CBM_6,Glyco_hydro_16,Laminin_G_3,PKD
CMS3_k127_3632014_2	391625.PPSIR1_32402	1.565e-05	51.0	COG1595@1|root,COG1595@2|Bacteria,1PEYN@1224|Proteobacteria,42ST1@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3632026_0	323259.Mhun_3051	4.175e-61	216.0	COG0863@1|root,arCOG00890@2157|Archaea,2XWFW@28890|Euryarchaeota,2NBA0@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
CMS3_k127_3632026_2	767029.HMPREF9154_1261	9.587e-08	64.0	COG3393@1|root,COG3393@2|Bacteria,2GMD2@201174|Actinobacteria,4DP1G@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF4081)	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,DUF4081,FR47
CMS3_k127_3632026_1	459349.CLOAM0956	1.951e-14	83.0	COG1266@1|root,COG1668@1|root,COG1266@2|Bacteria,COG1668@2|Bacteria,2NPVM@2323|unclassified Bacteria	2|Bacteria	CP	ABC-2 family transporter protein	natB	-	-	ko:K01992,ko:K07052,ko:K09696	ko02010,ko02020,map02010,map02020	M00253,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.115	-	iYO844.BSU02760	ABC2_membrane_2,ABC2_membrane_3,Abi
CMS3_k127_3635034_1	344747.PM8797T_17222	2.881e-140	455.0	COG2010@1|root,COG2010@2|Bacteria,2IY86@203682|Planctomycetes	203682|Planctomycetes	C	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PSCyt1,PSCyt2,PSD1
CMS3_k127_3635034_0	344747.PM8797T_13063	1.196e-170	549.0	COG3119@1|root,COG3119@2|Bacteria,2IXUN@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS3_k127_3637715_1	382464.ABSI01000013_gene1627	9.647e-20	98.0	COG4249@1|root,COG4249@2|Bacteria,46VKQ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3637715_0	313612.L8106_21167	2.19e-102	351.0	COG2823@1|root,COG2823@2|Bacteria,1G9YH@1117|Cyanobacteria	1117|Cyanobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
CMS3_k127_3637863_1	1265503.KB905160_gene2608	2.372e-30	133.0	2DABX@1|root,32TV4@2|Bacteria,1N0Q8@1224|Proteobacteria,1SAC9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3637863_0	1303518.CCALI_00760	4.743e-196	639.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	Abhydrolase_3,COesterase,Esterase,Peptidase_S9
CMS3_k127_3645313_0	1049564.TevJSym_ab00470	3.204e-35	153.0	2A6A4@1|root,30V2R@2|Bacteria,1RENE@1224|Proteobacteria,1SNHE@1236|Gammaproteobacteria,1JA5P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3645372_0	1121920.AUAU01000008_gene1614	1.385e-174	578.0	COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	2|Bacteria	C	4Fe-4S dicluster domain	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molydop_binding
CMS3_k127_3645372_1	1406840.Q763_10990	3.81e-54	197.0	COG2010@1|root,COG2010@2|Bacteria,4NF0A@976|Bacteroidetes,1HXD9@117743|Flavobacteriia,2NTD8@237|Flavobacterium	976|Bacteroidetes	C	Cytochrome c7 and related cytochrome c	actA	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrom_CIII,Cytochrome_C7
CMS3_k127_3654868_11	754477.Q7C_605	8.369e-05	49.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,45ZZU@72273|Thiotrichales	72273|Thiotrichales	S	Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_3654868_6	1304885.AUEY01000040_gene1608	2.388e-68	248.0	COG0628@1|root,COG0628@2|Bacteria,1PTH3@1224|Proteobacteria,42T9W@68525|delta/epsilon subdivisions,2WPRE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CMS3_k127_3654868_1	1411123.JQNH01000001_gene690	1.469e-146	477.0	COG1524@1|root,COG1524@2|Bacteria,1P235@1224|Proteobacteria,2U2XB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
CMS3_k127_3654868_4	237727.NAP1_12658	2.047e-77	276.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,2K0BH@204457|Sphingomonadales	204457|Sphingomonadales	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_3654868_10	7370.XP_005183738.1	9.824e-08	64.0	COG3914@1|root,KOG4626@2759|Eukaryota,38EM5@33154|Opisthokonta,3BC3N@33208|Metazoa,3CWN6@33213|Bilateria,41VJW@6656|Arthropoda,3SGP8@50557|Insecta,4505I@7147|Diptera	33208|Metazoa	GOT	Tetratricopeptide repeat	OGT	GO:0000003,GO:0000123,GO:0000785,GO:0000791,GO:0001678,GO:0001932,GO:0001933,GO:0001934,GO:0002119,GO:0002164,GO:0002237,GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0005488,GO:0005515,GO:0005543,GO:0005547,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0006040,GO:0006041,GO:0006047,GO:0006048,GO:0006073,GO:0006091,GO:0006109,GO:0006110,GO:0006111,GO:0006112,GO:0006139,GO:0006140,GO:0006325,GO:0006355,GO:0006357,GO:0006464,GO:0006470,GO:0006473,GO:0006475,GO:0006479,GO:0006486,GO:0006493,GO:0006508,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006996,GO:0007005,GO:0007154,GO:0007165,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007444,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0007626,GO:0008080,GO:0008134,GO:0008150,GO:0008152,GO:0008194,GO:0008213,GO:0008219,GO:0008289,GO:0008361,GO:0008375,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009605,GO:0009607,GO:0009617,GO:0009636,GO:0009719,GO:0009725,GO:0009743,GO:0009746,GO:0009749,GO:0009791,GO:0009888,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009966,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010562,GO:0010563,GO:0010604,GO:0010605,GO:0010628,GO:0010638,GO:0010646,GO:0010675,GO:0010799,GO:0010801,GO:0010876,GO:0010906,GO:0010941,GO:0012501,GO:0012505,GO:0015980,GO:0016020,GO:0016043,GO:0016262,GO:0016311,GO:0016407,GO:0016410,GO:0016485,GO:0016569,GO:0016570,GO:0016571,GO:0016573,GO:0016579,GO:0016740,GO:0016746,GO:0016747,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0018022,GO:0018023,GO:0018130,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019725,GO:0019904,GO:0019915,GO:0022607,GO:0023051,GO:0023052,GO:0030141,GO:0030162,GO:0030246,GO:0030808,GO:0030811,GO:0030900,GO:0031056,GO:0031058,GO:0031060,GO:0031062,GO:0031248,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0031396,GO:0031397,GO:0031399,GO:0031400,GO:0031401,GO:0031410,GO:0031667,GO:0031974,GO:0031981,GO:0031982,GO:0032259,GO:0032268,GO:0032269,GO:0032270,GO:0032386,GO:0032387,GO:0032434,GO:0032435,GO:0032496,GO:0032501,GO:0032502,GO:0032535,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032880,GO:0032922,GO:0032991,GO:0033036,GO:0033043,GO:0033044,GO:0033135,GO:0033137,GO:0033157,GO:0033218,GO:0033500,GO:0033993,GO:0034284,GO:0034641,GO:0034645,GO:0034654,GO:0034968,GO:0035020,GO:0035091,GO:0035220,GO:0035295,GO:0035556,GO:0036094,GO:0036211,GO:0036477,GO:0040024,GO:0042176,GO:0042177,GO:0042221,GO:0042277,GO:0042325,GO:0042326,GO:0042327,GO:0042578,GO:0042588,GO:0042592,GO:0042593,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043255,GO:0043412,GO:0043413,GO:0043414,GO:0043434,GO:0043467,GO:0043470,GO:0043543,GO:0043933,GO:0043967,GO:0043981,GO:0043982,GO:0043984,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044271,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045475,GO:0045793,GO:0045861,GO:0045862,GO:0045893,GO:0045935,GO:0045936,GO:0045937,GO:0045944,GO:0046349,GO:0046483,GO:0046578,GO:0046626,GO:0048015,GO:0048017,GO:0048029,GO:0048311,GO:0048312,GO:0048471,GO:0048511,GO:0048512,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051051,GO:0051056,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051193,GO:0051196,GO:0051223,GO:0051224,GO:0051235,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051276,GO:0051291,GO:0051568,GO:0051604,GO:0051640,GO:0051641,GO:0051646,GO:0051704,GO:0051707,GO:0051716,GO:0055082,GO:0055086,GO:0055114,GO:0060255,GO:0060322,GO:0060341,GO:0060429,GO:0060548,GO:0061085,GO:0061087,GO:0061136,GO:0062012,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0070085,GO:0070201,GO:0070206,GO:0070207,GO:0070208,GO:0070646,GO:0070647,GO:0070887,GO:0071216,GO:0071219,GO:0071222,GO:0071310,GO:0071322,GO:0071326,GO:0071331,GO:0071333,GO:0071375,GO:0071396,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0080182,GO:0090066,GO:0090087,GO:0090313,GO:0090315,GO:0090317,GO:0097237,GO:0097363,GO:0097458,GO:0097708,GO:0099503,GO:0120025,GO:0140096,GO:1900037,GO:1900038,GO:1900076,GO:1900180,GO:1900182,GO:1900371,GO:1900542,GO:1901071,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901799,GO:1901981,GO:1902275,GO:1902493,GO:1902494,GO:1902531,GO:1902680,GO:1903050,GO:1903051,GO:1903320,GO:1903321,GO:1903362,GO:1903363,GO:1903426,GO:1903428,GO:1903506,GO:1903508,GO:1903533,GO:1903578,GO:1903827,GO:1903828,GO:1903829,GO:1904950,GO:1905269,GO:1905475,GO:1905476,GO:1990234,GO:2000058,GO:2000059,GO:2000112,GO:2000377,GO:2000379,GO:2001141,GO:2001169,GO:2001252	2.4.1.255	ko:K09667	ko00514,ko04931,map00514,map04931	-	R09304,R09676	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003,ko03036	-	GT41	-	Glyco_transf_41,TPR_1,TPR_11,TPR_2,TPR_8
CMS3_k127_3654868_3	864051.BurJ1DRAFT_1472	1.353e-78	274.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,1KJ64@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_3654868_2	1267005.KB911255_gene2473	3.364e-85	291.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2TR7F@28211|Alphaproteobacteria,3N61R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ABC transporter	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
CMS3_k127_3654868_8	247490.KSU1_D0953	2.547e-20	105.0	COG0681@1|root,COG0681@2|Bacteria,2IYWI@203682|Planctomycetes	203682|Planctomycetes	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
CMS3_k127_3654868_0	868595.Desca_1886	1.351e-225	714.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,260S7@186807|Peptococcaceae	186801|Clostridia	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
CMS3_k127_3654868_7	767817.Desgi_2181	2.597e-39	157.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,261IR@186807|Peptococcaceae	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
CMS3_k127_3654868_5	1121289.JHVL01000041_gene3061	5.74e-75	261.0	COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,36DSU@31979|Clostridiaceae	186801|Clostridia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	Ham1p_like,RNase_PH,RNase_PH_C
CMS3_k127_3654868_9	595460.RRSWK_03527	1.044e-16	94.0	COG2304@1|root,COG2304@2|Bacteria,2J43F@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_3
CMS3_k127_3660243_2	326427.Cagg_2828	0.0002624	53.0	COG1807@1|root,COG1807@2|Bacteria,2GAB8@200795|Chloroflexi,374WB@32061|Chloroflexia	32061|Chloroflexia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_3660243_0	68170.KL590493_gene6298	1.285e-127	421.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,2I5Z7@201174|Actinobacteria,4E2FS@85010|Pseudonocardiales	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	2.4.1.289	ko:K16870	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glyco_trans_2_3,Glycos_transf_2
CMS3_k127_3660243_1	1121272.KB903253_gene6886	1.007e-06	57.0	COG0438@1|root,COG0438@2|Bacteria,2IN8Y@201174|Actinobacteria,4D9G5@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
CMS3_k127_366197_0	443144.GM21_0134	8.366e-281	877.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2WJ20@28221|Deltaproteobacteria,43U9W@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
CMS3_k127_36744_1	909663.KI867150_gene338	8.039e-31	144.0	COG1572@1|root,COG2931@1|root,COG3209@1|root,COG3291@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,2MS15@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4150,RHS,RHS_repeat,Transglut_core
CMS3_k127_36744_2	909663.KI867150_gene340	5.92e-23	118.0	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
CMS3_k127_36744_3	1396141.BATP01000057_gene2994	0.0002303	56.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	ko:K12678	-	-	-	-	ko00000,ko02000,ko02044	1.B.12.1.1,1.B.12.1.3	-	-	-
CMS3_k127_36744_0	1046714.AMRX01000006_gene2343	4.586e-70	274.0	COG2911@1|root,COG4412@1|root,COG2911@2|Bacteria,COG4412@2|Bacteria,1R1M5@1224|Proteobacteria,1RQBW@1236|Gammaproteobacteria,465Y0@72275|Alteromonadaceae	1236|Gammaproteobacteria	A	Protein conserved in bacteria	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
CMS3_k127_3683484_3	536233.CLO_0185	4.773e-14	76.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,36DWB@31979|Clostridiaceae	186801|Clostridia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
CMS3_k127_3683484_0	1449347.JQLN01000003_gene5752	1.614e-76	281.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,2M29R@2063|Kitasatospora	201174|Actinobacteria	M	Mur ligase family, catalytic domain	murC	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS3_k127_3683484_1	1122139.KB907879_gene2889	2.478e-53	210.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1XIP2@135619|Oceanospirillales	135619|Oceanospirillales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
CMS3_k127_3683484_4	1142394.PSMK_14520	0.0002194	53.0	COG1652@1|root,COG1652@2|Bacteria	2|Bacteria	S	positive regulation of growth rate	-	-	-	-	-	-	-	-	-	-	-	-	BON,Gmad2,LysM
CMS3_k127_3683484_2	445973.CLOBAR_02804	6.491e-39	155.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,25QJI@186804|Peptostreptococcaceae	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
CMS3_k127_3688050_3	314230.DSM3645_12951	0.0001528	51.0	COG1595@1|root,COG1595@2|Bacteria,2IZFC@203682|Planctomycetes	203682|Planctomycetes	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ECF,Sigma70_r2,Sigma70_r4_2
CMS3_k127_3688050_1	497964.CfE428DRAFT_0237	1.635e-38	164.0	2BMSD@1|root,32GBT@2|Bacteria,46VIR@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3688050_0	1254432.SCE1572_40310	5.65e-199	631.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,430DD@68525|delta/epsilon subdivisions,2WVKB@28221|Deltaproteobacteria,2YUBR@29|Myxococcales	28221|Deltaproteobacteria	F	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	ligB	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
CMS3_k127_3689306_0	1121920.AUAU01000005_gene995	8.463e-22	112.0	COG0515@1|root,COG0515@2|Bacteria,3Y3NW@57723|Acidobacteria	57723|Acidobacteria	T	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_3690119_0	595460.RRSWK_04778	1.424e-103	352.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12,TPR_8
CMS3_k127_3690119_2	296591.Bpro_3643	1.273e-08	64.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,4AA53@80864|Comamonadaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3690119_1	1111069.TCCBUS3UF1_1620	6.072e-42	176.0	COG4870@1|root,COG4870@2|Bacteria,1WM2I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	PFAM Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
CMS3_k127_369694_1	557599.MKAN_18645	9.176e-16	82.0	COG1225@1|root,COG1225@2|Bacteria,2IIDG@201174|Actinobacteria,239TX@1762|Mycobacteriaceae	201174|Actinobacteria	O	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,AhpC-TSA_2
CMS3_k127_369694_2	1122132.AQYH01000010_gene4084	2.997e-05	47.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,4B855@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Peroxiredoxin	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
CMS3_k127_3698164_0	1121920.AUAU01000008_gene1619	0.0	1701.0	COG5013@1|root,COG5013@2|Bacteria	2|Bacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0042126,GO:0043436,GO:0043546,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0097159,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204,GO:2001057	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	iSBO_1134.SBO_1842,iUMN146_1321.UM146_09685	Molybdopterin,Molydop_binding,Nitr_red_alph_N
CMS3_k127_3698164_1	1121920.AUAU01000008_gene1620	1.387e-44	172.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0328	Cytochrom_C,Cytochrome_CBB3
CMS3_k127_3701484_0	1278073.MYSTI_05718	1.622e-11	77.0	COG0823@1|root,COG3291@1|root,COG4932@1|root,COG0823@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,43C2M@68525|delta/epsilon subdivisions,2X7D7@28221|Deltaproteobacteria,2Z3FP@29|Myxococcales	28221|Deltaproteobacteria	MU	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD
CMS3_k127_3704689_2	1122164.JHWF01000017_gene581	8.485e-10	72.0	2BVG0@1|root,32QV2@2|Bacteria,1QN3M@1224|Proteobacteria,1TKHB@1236|Gammaproteobacteria,1JDZA@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3704689_1	378806.STAUR_6622	7.756e-18	91.0	COG4585@1|root,COG4585@2|Bacteria,1RAKD@1224|Proteobacteria,43AP2@68525|delta/epsilon subdivisions,2X62V@28221|Deltaproteobacteria,2YY8S@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
CMS3_k127_3709321_0	706587.Desti_0642	1e-13	74.0	COG2764@1|root,COG2764@2|Bacteria,1PGQC@1224|Proteobacteria,4376D@68525|delta/epsilon subdivisions,2X25Y@28221|Deltaproteobacteria,2MSCE@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_3713049_2	331869.BAL199_04309	1.973e-07	57.0	COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,2TV2I@28211|Alphaproteobacteria,4BQKY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
CMS3_k127_3713049_1	1121403.AUCV01000063_gene4179	1.097e-74	268.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,42PZ3@68525|delta/epsilon subdivisions,2WJU4@28221|Deltaproteobacteria,2MIHB@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS3_k127_3713049_0	313628.LNTAR_00305	2.228e-167	554.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23,HlyD_D4
CMS3_k127_3714774_1	882082.SaccyDRAFT_0652	5.202e-09	69.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4DYIP@85010|Pseudonocardiales	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS3_k127_3714774_2	1292034.OR37_01079	3.026e-06	57.0	COG1595@1|root,COG1595@2|Bacteria,1N413@1224|Proteobacteria,2U89X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3714774_0	204669.Acid345_2310	8.498e-96	347.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria,2JMN2@204432|Acidobacteriia	204432|Acidobacteriia	T	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
CMS3_k127_3716056_0	391625.PPSIR1_08496	2.01e-72	256.0	COG2234@1|root,COG2234@2|Bacteria,1PY1F@1224|Proteobacteria,4350U@68525|delta/epsilon subdivisions,2WZBN@28221|Deltaproteobacteria,2Z1SK@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS3_k127_3716056_2	1121106.JQKB01000027_gene1869	4.422e-49	180.0	COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,2UBYB@28211|Alphaproteobacteria,2JTMR@204441|Rhodospirillales	204441|Rhodospirillales	T	TspO/MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
CMS3_k127_3716056_1	1123508.JH636439_gene929	6.876e-56	214.0	COG0265@1|root,COG4412@1|root,COG0265@2|Bacteria,COG4412@2|Bacteria,2J16X@203682|Planctomycetes	203682|Planctomycetes	O	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M6
CMS3_k127_3716547_1	1123401.JHYQ01000008_gene456	4.029e-09	64.0	2C6TB@1|root,32RHR@2|Bacteria,1RKX5@1224|Proteobacteria,1SPS0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3716547_0	316067.Geob_2222	2.384e-17	93.0	2C6TB@1|root,32RHR@2|Bacteria,1RKX5@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3716547_2	1173028.ANKO01000233_gene2462	3.744e-08	66.0	COG2197@1|root,COG2197@2|Bacteria,1G85K@1117|Cyanobacteria,1HC90@1150|Oscillatoriales	1117|Cyanobacteria	K	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE
CMS3_k127_3716547_3	448385.sce6218	1.103e-07	63.0	COG1595@1|root,COG1595@2|Bacteria,1Q3FA@1224|Proteobacteria,4397F@68525|delta/epsilon subdivisions,2X4EA@28221|Deltaproteobacteria,2YYUV@29|Myxococcales	28221|Deltaproteobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3718346_2	391625.PPSIR1_40170	4.359e-48	181.0	COG0518@1|root,COG0518@2|Bacteria	2|Bacteria	F	GMP synthase (glutamine-hydrolyzing) activity	guaA_2	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
CMS3_k127_3718346_5	1121428.DESHY_40085___1	0.0005772	49.0	COG5662@1|root,COG5662@2|Bacteria,1U216@1239|Firmicutes,25N56@186801|Clostridia,2631J@186807|Peptococcaceae	186801|Clostridia	K	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349,zf-HC2
CMS3_k127_3718346_3	1519439.JPJG01000104_gene1835	3.379e-28	122.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,2N772@216572|Oscillospiraceae	186801|Clostridia	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3718346_0	338963.Pcar_1487	4.087e-105	360.0	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,42QBM@68525|delta/epsilon subdivisions,2WNZE@28221|Deltaproteobacteria,43UUH@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
CMS3_k127_3718346_4	379066.GAU_3127	5.69e-09	67.0	29G7B@1|root,30Q7A@2|Bacteria,1ZUZ6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF4184)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4184
CMS3_k127_3718346_1	1248232.BANQ01000033_gene3669	3.893e-101	337.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria,1Y07Z@135623|Vibrionales	135623|Vibrionales	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
CMS3_k127_3725618_0	1434325.AZQN01000006_gene3304	2.047e-41	175.0	COG0546@1|root,COG2870@1|root,COG0546@2|Bacteria,COG2870@2|Bacteria,4NJ8F@976|Bacteroidetes,47MRA@768503|Cytophagia	976|Bacteroidetes	M	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase,PfkB
CMS3_k127_3725618_1	314230.DSM3645_19703	1.721e-35	149.0	COG0265@1|root,COG0750@1|root,COG0265@2|Bacteria,COG0750@2|Bacteria,2IXR8@203682|Planctomycetes	203682|Planctomycetes	MO	MucD-putative a secreted serine proteinase	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Thioredoxin_7
CMS3_k127_3725618_2	235909.GK2884	3.033e-34	142.0	COG1670@1|root,COG1670@2|Bacteria,1UI20@1239|Firmicutes,4HITK@91061|Bacilli,1WG84@129337|Geobacillus	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_3738721_0	448385.sce1844	0.000228	54.0	COG4932@1|root,COG4932@2|Bacteria,1Q2N2@1224|Proteobacteria,4388V@68525|delta/epsilon subdivisions,2X3IH@28221|Deltaproteobacteria,2YW8A@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,PDZ_2
CMS3_k127_3740346_1	1121447.JONL01000004_gene2763	1.3e-06	58.0	2E2N5@1|root,32XRA@2|Bacteria,1N44M@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3740346_0	1121447.JONL01000004_gene2762	1.901e-21	98.0	2E57Z@1|root,3300G@2|Bacteria,1NBSS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3740346_2	224324.aq_1450	2.636e-05	55.0	COG0265@1|root,COG0265@2|Bacteria,2G3MU@200783|Aquificae	200783|Aquificae	M	PFAM peptidase S1 and S6 chymotrypsin Hap	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_3749163_1	1123371.ATXH01000025_gene187	5.925e-141	458.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS3_k127_3749163_4	489825.LYNGBM3L_21140	2.593e-25	121.0	COG1216@1|root,COG1216@2|Bacteria,1FZX3@1117|Cyanobacteria,1HA1F@1150|Oscillatoriales	2|Bacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	GlcNAc,Glyco_tranf_2_3,Glycos_transf_2
CMS3_k127_3749163_3	118163.Ple7327_1364	1.853e-77	277.0	COG0463@1|root,COG0463@2|Bacteria,1G4QA@1117|Cyanobacteria,3VJPS@52604|Pleurocapsales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_3749163_2	1123508.JH636449_gene7418	5.553e-124	424.0	COG1680@1|root,COG1680@2|Bacteria,2J0ZW@203682|Planctomycetes	203682|Planctomycetes	V	Beta-lactamase class C	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_3749163_0	756272.Plabr_2404	1.174e-151	492.0	COG3119@1|root,COG3119@2|Bacteria,2IY75@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.8	ko:K01134	ko00600,ko04142,map00600,map04142	-	R04856	RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS3_k127_3760316_0	1131269.AQVV01000004_gene638	5.919e-58	207.0	COG1509@1|root,COG1509@2|Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
CMS3_k127_3760316_1	1121405.dsmv_0582	1.62e-33	139.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,42TDG@68525|delta/epsilon subdivisions,2WPJP@28221|Deltaproteobacteria,2MK47@213118|Desulfobacterales	28221|Deltaproteobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
CMS3_k127_3762736_2	1123070.KB899261_gene2138	1.42e-13	84.0	295V5@1|root,2ZT65@2|Bacteria,46WNU@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3762736_1	1322246.BN4_20103	7.584e-30	124.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,43EDC@68525|delta/epsilon subdivisions,2X9DJ@28221|Deltaproteobacteria,2MC0Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS3_k127_3762736_0	1123371.ATXH01000033_gene422	5.867e-134	439.0	COG0151@1|root,COG0151@2|Bacteria,2GGTX@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC,GARS_A,GARS_C,GARS_N
CMS3_k127_3765636_0	1255043.TVNIR_1740	3.903e-170	548.0	COG0457@1|root,COG0457@2|Bacteria,1R1XZ@1224|Proteobacteria	1224|Proteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4071
CMS3_k127_3780339_1	530564.Psta_1326	2.376e-131	434.0	COG3119@1|root,COG3119@2|Bacteria,2IYH5@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_3780339_0	1278073.MYSTI_07489	2.234e-138	462.0	COG3011@1|root,COG3011@2|Bacteria,1N0MB@1224|Proteobacteria,42S3P@68525|delta/epsilon subdivisions,2WNCE@28221|Deltaproteobacteria,2YUQB@29|Myxococcales	28221|Deltaproteobacteria	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,LMF1
CMS3_k127_3780339_2	502025.Hoch_5969	5.822e-47	176.0	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,42R7J@68525|delta/epsilon subdivisions,2WMT4@28221|Deltaproteobacteria,2Z0Y2@29|Myxococcales	28221|Deltaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.17.1.4	ko:K13479	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
CMS3_k127_3782357_0	1313172.YM304_34270	3.383e-84	285.0	COG0450@1|root,COG0450@2|Bacteria,2GM74@201174|Actinobacteria,4CMXQ@84992|Acidimicrobiia	84992|Acidimicrobiia	O	C-terminal domain of 1-Cys peroxiredoxin	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
CMS3_k127_3782357_1	1379698.RBG1_1C00001G0657	9.806e-49	177.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	Z012_09115	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
CMS3_k127_3782357_2	251229.Chro_2155	5.955e-46	184.0	COG2244@1|root,COG2244@2|Bacteria,1G3GP@1117|Cyanobacteria,3VM1T@52604|Pleurocapsales	1117|Cyanobacteria	S	Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt_3,Polysacc_synt_C
CMS3_k127_3782357_3	511.JT27_16315	7.598e-07	62.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,3T228@506|Alcaligenaceae	28216|Betaproteobacteria	M	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_3782357_4	1033744.CAEL01000015_gene95	5.656e-05	55.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,22GB3@1570339|Peptoniphilaceae	186801|Clostridia	O	cog cog0265	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_3783657_0	1089548.KI783301_gene617	2.135e-123	416.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,4H9VD@91061|Bacilli,3WE7R@539002|Bacillales incertae sedis	91061|Bacilli	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0051179,GO:0051234,GO:0071702	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
CMS3_k127_3783657_1	1205680.CAKO01000040_gene984	1.205e-12	79.0	COG2755@1|root,COG2755@2|Bacteria,1NHW6@1224|Proteobacteria	1224|Proteobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS3_k127_3783657_2	316058.RPB_1260	2.716e-11	77.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2TZIX@28211|Alphaproteobacteria,3JSF7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	hyfB	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
CMS3_k127_3787462_0	926561.KB900617_gene1699	3.071e-124	419.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,3WAAY@53433|Halanaerobiales	186801|Clostridia	NU	PFAM type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
CMS3_k127_3787462_2	379066.GAU_2075	0.0009022	49.0	COG2165@1|root,COG2165@2|Bacteria,1ZTUY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Type II secretion system (T2SS), protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
CMS3_k127_3787462_1	767434.Fraau_0108	3.577e-25	117.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1X345@135614|Xanthomonadales	135614|Xanthomonadales	U	General secretion pathway protein	xpsF	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
CMS3_k127_379215_4	530564.Psta_4044	1.329e-19	103.0	COG0515@1|root,COG0515@2|Bacteria,2IWY8@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_379215_1	1123368.AUIS01000011_gene1139	2.013e-74	281.0	COG1404@1|root,COG1404@2|Bacteria,1R90Q@1224|Proteobacteria,1S01H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
CMS3_k127_379215_5	395492.Rleg2_4505	5.748e-05	53.0	COG1595@1|root,COG1595@2|Bacteria,1RKMN@1224|Proteobacteria,2U9GS@28211|Alphaproteobacteria,4BDTH@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_379215_2	269482.Bcep1808_6035	2.688e-54	195.0	COG3837@1|root,COG3837@2|Bacteria,1N15Q@1224|Proteobacteria,2VTYS@28216|Betaproteobacteria,1K8JK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_379215_3	1191523.MROS_0856	5.325e-54	195.0	COG2606@1|root,COG2606@2|Bacteria	2|Bacteria	S	Cys-tRNA(Pro) hydrolase activity	-	-	-	ko:K03976,ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
CMS3_k127_379215_0	886293.Sinac_2761	1.165e-116	408.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IYTQ@203682|Planctomycetes	203682|Planctomycetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16
CMS3_k127_3813078_0	1123242.JH636435_gene2057	5.396e-59	233.0	COG0515@1|root,COG0515@2|Bacteria	1123242.JH636435_gene2057|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3813078_1	1089553.Tph_c12830	7.071e-15	76.0	COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,42G1Y@68295|Thermoanaerobacterales	186801|Clostridia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	ylmE	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
CMS3_k127_3823728_1	1448139.AI20_14240	4.941e-25	116.0	COG0457@1|root,COG0457@2|Bacteria,1P0WK@1224|Proteobacteria,1SU5D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
CMS3_k127_3823728_0	102129.Lepto7375DRAFT_0018	1.1e-96	346.0	COG1002@1|root,COG1002@2|Bacteria	2|Bacteria	V	DNA modification	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3826418_2	497964.CfE428DRAFT_6048	1.958e-61	224.0	COG2133@1|root,COG2133@2|Bacteria,46V3J@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Methane oxygenase PmoA	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
CMS3_k127_3826418_0	1278073.MYSTI_06487	6.552e-148	479.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2YXGA@29|Myxococcales	28221|Deltaproteobacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_3826418_1	1121920.AUAU01000018_gene1826	5.627e-90	315.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria	57723|Acidobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
CMS3_k127_3826418_3	247490.KSU1_C1665	4.986e-49	188.0	2EBFT@1|root,335GE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3826418_5	234267.Acid_5023	5.983e-05	53.0	COG3303@1|root,COG3303@2|Bacteria,3Y84F@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3828756_2	1298880.AUEV01000010_gene2874	2.589e-44	175.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	pknA	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0040007,GO:0042304,GO:0043085,GO:0043086,GO:0043170,GO:0043388,GO:0043412,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0051055,GO:0051098,GO:0051099,GO:0051101,GO:0051128,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS3_k127_3828756_0	525904.Tter_2592	1.275e-113	385.0	COG0215@1|root,COG1216@1|root,COG0215@2|Bacteria,COG1216@2|Bacteria,2NNP0@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
CMS3_k127_3828756_1	1120971.AUCA01000034_gene3112	2.114e-77	274.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,4HBEA@91061|Bacilli	91061|Bacilli	C	Dehydrogenase E1 component	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
CMS3_k127_3833110_7	344747.PM8797T_01644	4.301e-34	139.0	COG0452@1|root,COG0452@2|Bacteria,2IZJA@203682|Planctomycetes	203682|Planctomycetes	H	COG0452 Phosphopantothenoylcysteine synthetase decarboxylase	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP
CMS3_k127_3833110_4	1167006.UWK_02169	5.952e-58	229.0	COG1538@1|root,COG1538@2|Bacteria,1NQXF@1224|Proteobacteria,42ZDW@68525|delta/epsilon subdivisions,2WTVP@28221|Deltaproteobacteria,2MMSE@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS3_k127_3833110_2	575540.Isop_2326	9.07e-100	342.0	COG0577@1|root,COG0577@2|Bacteria,2IX11@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_3833110_3	530564.Psta_4732	2.666e-84	286.0	COG1136@1|root,COG1136@2|Bacteria,2IY81@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_3833110_6	1131269.AQVV01000053_gene214	7.484e-36	157.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,EF-hand_5,HlyD_3,HlyD_D23
CMS3_k127_3833110_5	1232437.KL662020_gene700	1.618e-57	228.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42PAC@68525|delta/epsilon subdivisions,2WKAD@28221|Deltaproteobacteria,2MMGU@213118|Desulfobacterales	28221|Deltaproteobacteria	M	HlyD membrane-fusion protein of T1SS	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS3_k127_3833110_8	1122609.AUGT01000010_gene3702	3.783e-22	101.0	COG0216@1|root,COG0216@2|Bacteria,2I7Z4@201174|Actinobacteria,4DRZQ@85009|Propionibacteriales	201174|Actinobacteria	J	RF-1 domain	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
CMS3_k127_3833110_1	338963.Pcar_2021	3.024e-114	375.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,42P5B@68525|delta/epsilon subdivisions,2WM02@28221|Deltaproteobacteria,43SDS@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Phosphorylase superfamily	mtnP	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2684	PNP_UDP_1
CMS3_k127_3833110_11	679935.Alfi_2286	0.000287	54.0	COG2982@1|root,COG3599@1|root,COG2982@2|Bacteria,COG3599@2|Bacteria,4NEJQ@976|Bacteroidetes,2FN9V@200643|Bacteroidia	976|Bacteroidetes	M	protein involved in outer membrane biogenesis	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
CMS3_k127_3833110_10	1335757.SPICUR_00960	1.387e-08	68.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,1WXRZ@135613|Chromatiales	135613|Chromatiales	M	PFAM AsmA family protein	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA
CMS3_k127_3833110_0	1313301.AUGC01000008_gene386	5.383e-179	569.0	COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes	976|Bacteroidetes	E	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_3833110_9	312309.VF_2245	6.792e-22	97.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,1XSIU@135623|Vibrionales	135623|Vibrionales	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
CMS3_k127_3840889_0	330214.NIDE4245	3.391e-31	133.0	COG1595@1|root,COG1595@2|Bacteria,3J1A1@40117|Nitrospirae	40117|Nitrospirae	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3840889_4	243365.CV_3103	0.0005659	53.0	COG1207@1|root,COG1207@2|Bacteria,1RD3B@1224|Proteobacteria,2W3EZ@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3840889_2	994573.T472_0218780	9.412e-21	102.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24BK7@186801|Clostridia	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CMS3_k127_3840889_3	1117318.PRUB_16737	2.653e-12	77.0	COG3239@1|root,COG3239@2|Bacteria,1RBBB@1224|Proteobacteria,1SAK4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
CMS3_k127_3840889_1	930166.CD58_21630	5.531e-27	112.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	-	-	2.5.1.48,4.4.1.1,4.4.1.2,4.4.1.8	ko:K01739,ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00609	R00782,R00999,R01001,R01283,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00487,RC00488,RC00710,RC01245,RC02303,RC02814,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
CMS3_k127_3857648_1	211165.AJLN01000104_gene6584	1.789e-76	263.0	COG1216@1|root,COG1216@2|Bacteria,1G2MT@1117|Cyanobacteria,1JKPF@1189|Stigonemataceae	1117|Cyanobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
CMS3_k127_3857648_0	344747.PM8797T_26105	4.516e-141	475.0	COG1413@1|root,COG2133@1|root,COG2755@1|root,COG1413@2|Bacteria,COG2133@2|Bacteria,COG2755@2|Bacteria,2IX6X@203682|Planctomycetes	203682|Planctomycetes	C	Membrane-bound dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,HEAT_2,Lipase_GDSL_2
CMS3_k127_3860371_0	1150626.PHAMO_460002	7.193e-132	423.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_3860371_1	1313421.JHBV01000162_gene845	2.428e-41	166.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
CMS3_k127_3860371_2	1150626.PHAMO_460004	1.534e-40	161.0	COG1936@1|root,COG1936@2|Bacteria	2|Bacteria	F	adenylate kinase activity	-	-	2.7.4.3	ko:K00939,ko:K18532	ko00230,ko00730,ko01100,ko01110,ko01130,ko03008,map00230,map00730,map01100,map01110,map01130,map03008	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009,ko04147	-	-	-	AAA_17,AAA_18,AAA_33
CMS3_k127_3860371_4	1206732.BAGD01000039_gene1322	2.256e-21	102.0	2EJQK@1|root,33DFE@2|Bacteria,2IND9@201174|Actinobacteria,4G291@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3860371_3	215803.DB30_4330	1.497e-21	104.0	COG1309@1|root,COG1309@2|Bacteria,1NBI7@1224|Proteobacteria,43944@68525|delta/epsilon subdivisions,2X4A3@28221|Deltaproteobacteria,2YYKP@29|Myxococcales	28221|Deltaproteobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	ko:K02167	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_6,TetR_N
CMS3_k127_3864691_1	1278073.MYSTI_05750	9.498e-29	134.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1R60D@1224|Proteobacteria,42UZ2@68525|delta/epsilon subdivisions,2WR0Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1,Glycos_transf_2
CMS3_k127_3864691_0	443143.GM18_0950	1.303e-78	274.0	COG0438@1|root,COG0438@2|Bacteria,1Q7RM@1224|Proteobacteria,42ZDC@68525|delta/epsilon subdivisions,2WU88@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
CMS3_k127_3864691_2	56107.Cylst_0338	4.869e-25	117.0	COG4122@1|root,COG4122@2|Bacteria,1G64A@1117|Cyanobacteria	1117|Cyanobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
CMS3_k127_3866805_1	521674.Plim_1437	2.72e-70	245.0	COG3345@1|root,COG3345@2|Bacteria,2IZER@203682|Planctomycetes	203682|Planctomycetes	G	Carbohydrate esterase, sialic acid-specific acetylesterase	-	-	-	-	-	-	-	-	-	-	-	-	SASA
CMS3_k127_3866805_0	1123508.JH636445_gene6533	8.607e-213	680.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2J2ME@203682|Planctomycetes	203682|Planctomycetes	E	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
CMS3_k127_3867138_1	448385.sce6205	2.618e-116	385.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,42N8C@68525|delta/epsilon subdivisions,2WM3N@28221|Deltaproteobacteria,2YUFY@29|Myxococcales	28221|Deltaproteobacteria	K	AlkA N-terminal domain	-	-	3.2.2.21	ko:K13529,ko:K13530	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
CMS3_k127_3867138_2	1123009.AUID01000024_gene1455	6.644e-28	119.0	2E12M@1|root,32WIA@2|Bacteria,1VD2B@1239|Firmicutes,24NKB@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3867138_0	1123508.JH636439_gene1798	1.086e-248	792.0	COG1506@1|root,COG1506@2|Bacteria,2IY8M@203682|Planctomycetes	203682|Planctomycetes	E	Dipeptidyl peptidase IV (DPP IV)	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,DUF885,Peptidase_S9,VHL
CMS3_k127_3872683_0	247490.KSU1_C1202	0.0	1220.0	COG0086@1|root,COG0086@2|Bacteria,2IXGN@203682|Planctomycetes	203682|Planctomycetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
CMS3_k127_3872683_4	232348.ADXL01000014_gene730	1.942e-28	124.0	COG4634@1|root,COG4634@2|Bacteria,1G6S3@1117|Cyanobacteria,1H23Q@1129|Synechococcus	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3872683_5	278957.ABEA03000095_gene4585	2.581e-25	106.0	COG2442@1|root,COG2442@2|Bacteria	2|Bacteria	K	InterPro IPR007367	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
CMS3_k127_3872683_2	247490.KSU1_C1203	2.238e-57	210.0	COG0048@1|root,COG0048@2|Bacteria,2IZR1@203682|Planctomycetes	203682|Planctomycetes	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
CMS3_k127_3872683_3	944480.ATUV01000001_gene1709	4.373e-52	190.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,42QR7@68525|delta/epsilon subdivisions,2WNFM@28221|Deltaproteobacteria,2M6XH@213113|Desulfurellales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
CMS3_k127_3872683_1	557599.MKAN_02240	2.417e-77	278.0	COG3779@1|root,COG3779@2|Bacteria,2ICPD@201174|Actinobacteria,2383V@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2314
CMS3_k127_3886046_0	1238182.C882_3662	2.601e-74	270.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2U5H1@28211|Alphaproteobacteria,2JRQN@204441|Rhodospirillales	204441|Rhodospirillales	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
CMS3_k127_3886046_1	234267.Acid_6442	2.534e-44	169.0	COG0177@1|root,COG0177@2|Bacteria,3Y8R4@57723|Acidobacteria	57723|Acidobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3886046_2	211165.AJLN01000063_gene3798	3.915e-44	171.0	COG1708@1|root,COG1708@2|Bacteria,1GKRV@1117|Cyanobacteria,1JMMM@1189|Stigonemataceae	1117|Cyanobacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3886046_3	1408473.JHXO01000008_gene2942	0.0001627	53.0	COG2804@1|root,COG2804@2|Bacteria,4NHT2@976|Bacteroidetes,2FPSR@200643|Bacteroidia	976|Bacteroidetes	NU	Type II/IV secretion system protein	gspE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
CMS3_k127_3891522_2	575540.Isop_0409	2.708e-19	104.0	COG1657@1|root,COG1657@2|Bacteria,2IXVT@203682|Planctomycetes	203682|Planctomycetes	I	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	A2M_comp,DUF4159,Prenyltrans
CMS3_k127_3891522_1	575540.Isop_0194	9.007e-70	250.0	COG0820@1|root,COG0820@2|Bacteria,2IXW1@203682|Planctomycetes	203682|Planctomycetes	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
CMS3_k127_3891522_0	575540.Isop_0580	4.297e-151	490.0	COG1219@1|root,COG1219@2|Bacteria,2IXDS@203682|Planctomycetes	203682|Planctomycetes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
CMS3_k127_3894690_2	96561.Dole_2627	1.774e-12	81.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	crtF	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_2,Methyltransf_23
CMS3_k127_3894690_1	489825.LYNGBM3L_07800	2.589e-86	314.0	COG1232@1|root,COG1232@2|Bacteria,1G05M@1117|Cyanobacteria,1H8M6@1150|Oscillatoriales	1117|Cyanobacteria	H	Protoporphyrinogen oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
CMS3_k127_3894690_0	1129794.C427_1223	3.299e-152	509.0	COG2706@1|root,COG3391@1|root,COG3637@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,COG3637@2|Bacteria,1QWRQ@1224|Proteobacteria,1T4S3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_389755_3	292415.Tbd_1452	4e-70	246.0	COG3271@1|root,COG3271@2|Bacteria,1RAD5@1224|Proteobacteria,2VIY6@28216|Betaproteobacteria,1KSUV@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_389755_0	1232410.KI421415_gene2975	3.861e-157	511.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,42MPG@68525|delta/epsilon subdivisions,2WKW8@28221|Deltaproteobacteria,43UK8@69541|Desulfuromonadales	28221|Deltaproteobacteria	HJ	RimK-like ATPgrasp N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK
CMS3_k127_389755_1	1232410.KI421415_gene2974	9.486e-122	404.0	COG2170@1|root,COG2170@2|Bacteria,1MY35@1224|Proteobacteria,42PBG@68525|delta/epsilon subdivisions,2WK4S@28221|Deltaproteobacteria,43UJW@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Glutamate-cysteine ligase family 2(GCS2)	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
CMS3_k127_389755_4	941449.dsx2_0408	1.515e-54	213.0	COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,42RKD@68525|delta/epsilon subdivisions,2WNAE@28221|Deltaproteobacteria,2M8XF@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
CMS3_k127_389755_2	1121405.dsmv_0232	7.563e-107	362.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43BS9@68525|delta/epsilon subdivisions,2X733@28221|Deltaproteobacteria,2MPJG@213118|Desulfobacterales	28221|Deltaproteobacteria	K	sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
CMS3_k127_3908427_0	497964.CfE428DRAFT_1665	3.207e-25	120.0	COG0392@1|root,COG0392@2|Bacteria,46T31@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS3_k127_3911335_2	493475.GARC_4265	1.212e-35	147.0	COG2931@1|root,COG2982@1|root,COG4733@1|root,COG2931@2|Bacteria,COG2982@2|Bacteria,COG4733@2|Bacteria,1MU7T@1224|Proteobacteria,1S1HJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,DUF4214,DUF4347,He_PIG,HemolysinCabind,PATR,VCBS
CMS3_k127_3911335_5	716544.wcw_0727	0.0003791	49.0	2AEHF@1|root,314CQ@2|Bacteria,2JGIZ@204428|Chlamydiae	204428|Chlamydiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3911335_3	397291.C804_01263	1.55e-18	92.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,27MPS@186928|unclassified Lachnospiraceae	186801|Clostridia	K	MraZ protein, putative antitoxin-like	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
CMS3_k127_3911335_0	269799.Gmet_0404	5.679e-77	269.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,42N5Q@68525|delta/epsilon subdivisions,2WJ8J@28221|Deltaproteobacteria,43TQT@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
CMS3_k127_3911335_1	941449.dsx2_1563	1.744e-38	165.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,2M7SV@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM penicillin-binding protein transpeptidase	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
CMS3_k127_3911335_4	504832.OCAR_5237	8.996e-10	67.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria,3JS79@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS3_k127_3923084_0	1500893.JQNB01000001_gene1020	0.0	1103.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1X46E@135614|Xanthomonadales	135614|Xanthomonadales	L	Helicase	lhr1	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
CMS3_k127_3928951_0	234267.Acid_3971	4.467e-61	217.0	COG1252@1|root,COG1252@2|Bacteria,3Y308@57723|Acidobacteria	57723|Acidobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
CMS3_k127_3928951_1	903818.KI912268_gene2085	0.0001483	48.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
CMS3_k127_3934676_1	502025.Hoch_3416	9.232e-66	233.0	COG0402@1|root,COG0402@2|Bacteria,1Q1P7@1224|Proteobacteria,42U3F@68525|delta/epsilon subdivisions,2WR49@28221|Deltaproteobacteria,2YVEP@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	ssnA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_3934676_0	530564.Psta_4256	0.0	1331.0	COG2010@1|root,COG2133@1|root,COG3474@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,COG3474@2|Bacteria,2IY0D@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
CMS3_k127_3934984_0	521674.Plim_2376	1.58e-104	353.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS3_k127_3934984_1	765420.OSCT_0910	9.83e-24	116.0	COG0457@1|root,COG1716@1|root,COG4447@1|root,COG0457@2|Bacteria,COG1716@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CarboxypepD_reg,FHA,Kelch_4,NHL,PA14,Peptidase_C11
CMS3_k127_3934984_3	661478.OP10G_0324	5.243e-10	66.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS3_k127_3943224_5	926692.AZYG01000056_gene459	1.557e-09	60.0	COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,248G1@186801|Clostridia,3WB77@53433|Halanaerobiales	186801|Clostridia	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1,HHH_3
CMS3_k127_3943224_4	103733.JNYO01000028_gene8966	2.118e-11	74.0	COG1595@1|root,COG1595@2|Bacteria,2GM8T@201174|Actinobacteria,4DY2F@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigD	GO:0000988,GO:0000990,GO:0002791,GO:0003674,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032879,GO:0032880,GO:0043254,GO:0044087,GO:0044419,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051223,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070201,GO:0080090,GO:0090087,GO:0140110,GO:1903506,GO:1903530,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_3943224_1	1210884.HG799463_gene9871	5.864e-110	394.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,WD40
CMS3_k127_3943224_3	1121447.JONL01000011_gene2358	7.474e-22	113.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,42T39@68525|delta/epsilon subdivisions,2WR3E@28221|Deltaproteobacteria,2MC62@213115|Desulfovibrionales	28221|Deltaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS3_k127_3943224_0	1193181.BN10_1600013	1.11e-113	410.0	COG1181@1|root,COG1181@2|Bacteria,2I7T3@201174|Actinobacteria,4FK2J@85021|Intrasporangiaceae	2|Bacteria	M	Evidence 4 Homologs of previously reported genes of	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	ATP-grasp,ATP-grasp_4,Dala_Dala_lig_C,Dala_Dala_lig_N
CMS3_k127_3943224_2	1380393.JHVP01000005_gene3589	2.358e-83	284.0	COG1181@1|root,COG1181@2|Bacteria,2I7XS@201174|Actinobacteria,4EWIZ@85013|Frankiales	2|Bacteria	M	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	ATP-grasp,ATP-grasp_4,Dala_Dala_lig_C,Dala_Dala_lig_N
CMS3_k127_3944618_1	545695.TREAZ_0286	9.507e-30	126.0	COG0564@1|root,COG0564@2|Bacteria,2J7HP@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the pseudouridine synthase RluA family	-	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS3_k127_3944618_4	1038867.AXAY01000020_gene3401	9.833e-10	70.0	COG0599@1|root,COG0599@2|Bacteria,1RH7V@1224|Proteobacteria,2UB7P@28211|Alphaproteobacteria,3JZMC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Carboxymuconolactone decarboxylase family	MA20_13090	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
CMS3_k127_3944618_3	1379698.RBG1_1C00001G0230	5.656e-25	119.0	COG2206@1|root,COG2206@2|Bacteria,2NPP4@2323|unclassified Bacteria	2|Bacteria	T	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS3_k127_3944618_2	861299.J421_2716	6.376e-26	117.0	COG0745@1|root,COG0745@2|Bacteria	861299.J421_2716|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3944618_0	292459.STH749	3.561e-49	195.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia	186801|Clostridia	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
CMS3_k127_3944618_5	439292.Bsel_1135	4.435e-09	63.0	COG1366@1|root,COG1366@2|Bacteria,1VERM@1239|Firmicutes,4HS01@91061|Bacilli	91061|Bacilli	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS3_k127_3950403_5	1235792.C808_05025	2.457e-15	88.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS3_k127_3950403_2	1168034.FH5T_17530	4.967e-93	318.0	2DB9P@1|root,2Z7Y1@2|Bacteria,4NHQN@976|Bacteroidetes,2G10W@200643|Bacteroidia	976|Bacteroidetes	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS3_k127_3950403_4	1121285.AUFK01000014_gene2665	3.398e-16	91.0	COG2350@1|root,COG2350@2|Bacteria,4NRC1@976|Bacteroidetes,1I447@117743|Flavobacteriia,3ZPYB@59732|Chryseobacterium	976|Bacteroidetes	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
CMS3_k127_3950403_1	1120985.AUMI01000019_gene2299	2.465e-103	348.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,4H2A2@909932|Negativicutes	909932|Negativicutes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS3_k127_3950403_3	391625.PPSIR1_02136	2.459e-83	291.0	COG0664@1|root,COG0664@2|Bacteria,1R5Z0@1224|Proteobacteria,42Q0Q@68525|delta/epsilon subdivisions,2WKKJ@28221|Deltaproteobacteria,2YVXW@29|Myxococcales	28221|Deltaproteobacteria	T	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_20,cNMP_binding
CMS3_k127_3950403_0	105559.Nwat_0935	6.369e-122	424.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1WXKG@135613|Chromatiales	135613|Chromatiales	DM	mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
CMS3_k127_3954140_1	1463825.JNXC01000003_gene3747	1.268e-15	91.0	COG2340@1|root,COG2340@2|Bacteria,2GM57@201174|Actinobacteria,4E4HQ@85010|Pseudonocardiales	201174|Actinobacteria	S	protein with SCP PR1 domains	-	-	-	-	-	-	-	-	-	-	-	-	CAP
CMS3_k127_3954140_0	404589.Anae109_4089	5.515e-29	131.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,42N6U@68525|delta/epsilon subdivisions,2WQ3X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
CMS3_k127_3962861_0	1499967.BAYZ01000039_gene2211	6.17e-136	442.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	pqqE	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS3_k127_3962861_1	509191.AEDB02000019_gene4458	8.173e-43	174.0	2CEJC@1|root,32R1S@2|Bacteria,1VRZ1@1239|Firmicutes,24YMS@186801|Clostridia,3WN5P@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3962861_2	595460.RRSWK_03096	8.007e-26	125.0	COG1657@1|root,COG1657@2|Bacteria,2IX8J@203682|Planctomycetes	203682|Planctomycetes	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3965100_3	204669.Acid345_1570	5.349e-11	72.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS3_k127_3965100_1	1173029.JH980292_gene3661	9.647e-51	188.0	COG0778@1|root,COG0778@2|Bacteria,1G4SQ@1117|Cyanobacteria,1H9DP@1150|Oscillatoriales	1117|Cyanobacteria	C	PFAM Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS3_k127_3965100_0	344747.PM8797T_25576	8.788e-275	881.0	COG0841@1|root,COG0841@2|Bacteria,2IY0K@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS3_k127_3965100_2	314230.DSM3645_23990	1.717e-40	166.0	COG0845@1|root,COG0845@2|Bacteria,2IYTR@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
CMS3_k127_3965100_4	187303.BN69_0141	1.488e-08	56.0	COG0500@1|root,COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2TQU4@28211|Alphaproteobacteria,37150@31993|Methylocystaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_3965187_4	1123508.JH636443_gene4662	1.893e-05	50.0	COG0457@1|root,COG0457@2|Bacteria,2J0VV@203682|Planctomycetes	203682|Planctomycetes	S	Iodothyronine deiodinase	-	-	-	-	-	-	-	-	-	-	-	-	T4_deiodinase
CMS3_k127_3965187_3	234267.Acid_3493	4.605e-18	89.0	COG0457@1|root,COG0457@2|Bacteria,3Y75T@57723|Acidobacteria	57723|Acidobacteria	S	Iodothyronine deiodinase	-	-	-	-	-	-	-	-	-	-	-	-	T4_deiodinase,TPR_16
CMS3_k127_3965187_1	502025.Hoch_6136	1.229e-247	782.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,42Q48@68525|delta/epsilon subdivisions,2X5G4@28221|Deltaproteobacteria,2YZF5@29|Myxococcales	28221|Deltaproteobacteria	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CMS3_k127_3965187_0	1216976.AX27061_1312	0.0	1130.0	COG1112@1|root,COG2852@1|root,COG1112@2|Bacteria,COG2852@2|Bacteria,1MWMG@1224|Proteobacteria,2VHWC@28216|Betaproteobacteria,3T4F2@506|Alcaligenaceae	28216|Betaproteobacteria	L	COG1112 Superfamily I DNA and RNA helicases and helicase subunits	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF3320,DUF4011,DUF559,GreA_GreB,IstB_IS21,WGR
CMS3_k127_3965187_2	1303518.CCALI_00626	2.717e-32	131.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
CMS3_k127_3967410_0	671143.DAMO_3131	2.637e-111	371.0	COG1077@1|root,COG1077@2|Bacteria,2NNVU@2323|unclassified Bacteria	2|Bacteria	D	MreB/Mbl protein	mreB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
CMS3_k127_3967410_3	1396141.BATP01000004_gene5889	5.08e-22	113.0	COG0768@1|root,COG0768@2|Bacteria,46TSQ@74201|Verrucomicrobia,2ITKB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
CMS3_k127_3967410_1	555079.Toce_0747	5.699e-55	211.0	COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,247WS@186801|Clostridia,42EMA@68295|Thermoanaerobacterales	186801|Clostridia	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
CMS3_k127_3967410_2	760568.Desku_0493	2.036e-30	132.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,262RV@186807|Peptococcaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3969005_2	240015.ACP_0479	3.429e-37	159.0	COG3005@1|root,COG3005@2|Bacteria,3Y4BJ@57723|Acidobacteria,2JJ2B@204432|Acidobacteriia	204432|Acidobacteriia	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS3_k127_3969005_3	1144275.COCOR_00167	5.891e-10	72.0	COG1413@1|root,COG1413@2|Bacteria,1QVTH@1224|Proteobacteria,43BXF@68525|delta/epsilon subdivisions,2X788@28221|Deltaproteobacteria,2YYVZ@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_19
CMS3_k127_3969005_0	247490.KSU1_C0199	5.336e-111	374.0	COG0621@1|root,COG0621@2|Bacteria,2IX1E@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
CMS3_k127_3969005_1	575540.Isop_0754	1.083e-75	270.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2IX5J@203682|Planctomycetes	203682|Planctomycetes	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
CMS3_k127_3970499_0	926561.KB900618_gene132	2.833e-107	376.0	COG1757@1|root,COG1757@2|Bacteria,1TP8A@1239|Firmicutes,247V4@186801|Clostridia,3WA9C@53433|Halanaerobiales	186801|Clostridia	C	PFAM Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
CMS3_k127_3970499_2	345341.KUTG_03785	0.0002156	53.0	COG2197@1|root,COG3903@1|root,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4E1QC@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	GerE,Guanylate_cyc,NB-ARC
CMS3_k127_3970499_1	880073.Calab_3492	4.335e-52	193.0	COG0017@1|root,COG0017@2|Bacteria,2NNQM@2323|unclassified Bacteria	2|Bacteria	J	tRNA synthetases class II (D, K and N)	asnS	GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
CMS3_k127_3980177_3	1101190.ARWB01000001_gene425	0.0003054	47.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2TQSA@28211|Alphaproteobacteria,36XRV@31993|Methylocystaceae	28211|Alphaproteobacteria	D	Cell cycle protein	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
CMS3_k127_3980177_1	1122244.AUGF01000030_gene1657	3.212e-86	298.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,3NJV1@468|Moraxellaceae	1236|Gammaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Glycos_transf_4,MraY_sig1
CMS3_k127_3980177_2	105559.Nwat_0223	4.549e-78	280.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1WWTC@135613|Chromatiales	135613|Chromatiales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS3_k127_3980177_0	717605.Theco_2322	9.575e-99	338.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,4H9T1@91061|Bacilli,26R8F@186822|Paenibacillaceae	91061|Bacilli	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS3_k127_399006_4	32042.PstZobell_15479	4.609e-24	109.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1Z0GI@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	F	Belongs to the 5'-nucleotidase family	yhcR	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
CMS3_k127_399006_5	1121405.dsmv_2905	2.646e-10	67.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P5K@68525|delta/epsilon subdivisions,2WIKI@28221|Deltaproteobacteria,2MI2G@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_399006_3	479434.Sthe_0043	6.192e-26	121.0	COG0859@1|root,COG0859@2|Bacteria,2GBDN@200795|Chloroflexi,27YZF@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
CMS3_k127_399006_2	1047013.AQSP01000104_gene1408	4.539e-96	345.0	COG0308@1|root,COG0308@2|Bacteria,2NPPZ@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M1 domain	pepN	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
CMS3_k127_399006_1	273068.TTE0523	1.919e-114	378.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,42EU5@68295|Thermoanaerobacterales	186801|Clostridia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CMS3_k127_399006_0	1405.DJ92_2921	4.749e-162	525.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H9YY@91061|Bacilli,1ZD5E@1386|Bacillus	91061|Bacilli	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
CMS3_k127_4010822_2	1396418.BATQ01000145_gene3536	8.374e-21	109.0	COG2010@1|root,COG2010@2|Bacteria,46U0M@74201|Verrucomicrobia,2IV63@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Protein of unknown function (DUF1549)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
CMS3_k127_4010822_1	1123508.JH636441_gene3161	4.842e-24	120.0	COG2319@1|root,COG2319@2|Bacteria,2IY5Q@203682|Planctomycetes	203682|Planctomycetes	M	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,PSCyt1,PSCyt2,PSD1,WD40
CMS3_k127_4010822_0	886293.Sinac_5384	1.331e-28	135.0	COG3064@1|root,COG3064@2|Bacteria,2IX90@203682|Planctomycetes	203682|Planctomycetes	M	Bacterial pre-peptidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	PPC
CMS3_k127_4018112_0	1158182.KB905020_gene2047	3.198e-54	210.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1S0WJ@1236|Gammaproteobacteria,1WWFB@135613|Chromatiales	135613|Chromatiales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
CMS3_k127_4019038_0	1210884.HG799464_gene10641	3.924e-208	696.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,2IXPU@203682|Planctomycetes	203682|Planctomycetes	C	heme-binding domain, Pirellula Verrucomicrobium type	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,HEAT_2
CMS3_k127_4019038_1	344747.PM8797T_06325	3.643e-140	492.0	COG2133@1|root,COG2133@2|Bacteria,2IWVG@203682|Planctomycetes	203682|Planctomycetes	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4019038_2	344747.PM8797T_15341	2.257e-11	67.0	2DV29@1|root,33TNQ@2|Bacteria	2|Bacteria	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4026030_3	999547.KI421500_gene2326	0.0002839	53.0	COG4886@1|root,COG4886@2|Bacteria,1MXKD@1224|Proteobacteria,2VFIV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Leucine-rich repeat (LRR) protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4026030_2	768671.ThimaDRAFT_3712	1.998e-50	193.0	COG4636@1|root,COG4636@2|Bacteria,1NTAK@1224|Proteobacteria,1SM5Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
CMS3_k127_4026030_1	404589.Anae109_4440	4.75e-132	436.0	COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,42M12@68525|delta/epsilon subdivisions,2WIJX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1312	Epimerase
CMS3_k127_4026030_0	443143.GM18_0754	2.955e-153	496.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,42KZY@68525|delta/epsilon subdivisions,2WJ4B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
CMS3_k127_4028132_1	449447.MAE_61060	2.137e-41	165.0	COG2931@1|root,COG2931@2|Bacteria,1GQCK@1117|Cyanobacteria	1117|Cyanobacteria	Q	PFAM Hemolysin-type calcium-binding	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Calx-beta,DUF4347,HemolysinCabind,VCBS
CMS3_k127_4028132_0	1303518.CCALI_02907	8.383e-70	261.0	COG5267@1|root,COG5267@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
CMS3_k127_4028132_2	266748.HY04_11805	1.086e-20	100.0	COG4102@1|root,COG4102@2|Bacteria,4NFFC@976|Bacteroidetes,1I0C6@117743|Flavobacteriia,3ZPA7@59732|Chryseobacterium	976|Bacteroidetes	S	Twin-arginine translocation pathway signal	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_4031127_0	1499967.BAYZ01000001_gene5910	0.0	1425.0	COG0525@1|root,COG0525@2|Bacteria,2NNKR@2323|unclassified Bacteria	2|Bacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
CMS3_k127_4031127_1	1232410.KI421421_gene3809	8.415e-67	251.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42NHE@68525|delta/epsilon subdivisions,2WJPP@28221|Deltaproteobacteria,43S3G@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
CMS3_k127_4031127_2	1131269.AQVV01000011_gene2509	2.814e-15	90.0	COG0428@1|root,COG0428@2|Bacteria	2|Bacteria	P	transporter	zupT	-	-	ko:K07238,ko:K11021,ko:K16267	-	-	-	-	ko00000,ko02000,ko02042	2.A.5.4.11,2.A.5.5	-	-	Zip
CMS3_k127_4033143_2	398767.Glov_2915	3.865e-18	100.0	COG0028@1|root,COG1361@1|root,COG3468@1|root,COG5492@1|root,COG0028@2|Bacteria,COG1361@2|Bacteria,COG3468@2|Bacteria,COG5492@2|Bacteria,1QVSF@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF11,DUF1566,Laminin_G_3,OmpA,OmpA_membrane,TIG
CMS3_k127_4033143_0	458817.Shal_1968	1.832e-53	213.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K09607	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PKD,SASA
CMS3_k127_4041719_1	886293.Sinac_0499	0.0	1141.0	COG0086@1|root,COG0086@2|Bacteria,2IXGN@203682|Planctomycetes	203682|Planctomycetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
CMS3_k127_4041719_0	671143.DAMO_0532	0.0	1197.0	COG0085@1|root,COG0085@2|Bacteria,2NNM9@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03043,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
CMS3_k127_4041719_2	1284708.HMPREF1634_08540	1.605e-35	137.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia,3WD9N@538999|Clostridiales incertae sedis	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
CMS3_k127_4064565_1	292459.STH1321	6.431e-18	99.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CAP,CW_binding_2,DUF4214,HemolysinCabind
CMS3_k127_4064565_0	1123508.JH636444_gene5281	3.027e-49	184.0	2CGF5@1|root,32WVC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4072372_1	493475.GARC_4265	9.989e-38	160.0	COG2931@1|root,COG2982@1|root,COG4733@1|root,COG2931@2|Bacteria,COG2982@2|Bacteria,COG4733@2|Bacteria,1MU7T@1224|Proteobacteria,1S1HJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,DUF4214,DUF4347,He_PIG,HemolysinCabind,PATR,VCBS
CMS3_k127_4072372_0	1129794.C427_1223	8.412e-110	387.0	COG2706@1|root,COG3391@1|root,COG3637@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,COG3637@2|Bacteria,1QWRQ@1224|Proteobacteria,1T4S3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4072372_2	1403313.AXBR01000005_gene1676	1.232e-18	89.0	COG0457@1|root,COG0457@2|Bacteria,1VDUM@1239|Firmicutes,4I0ZA@91061|Bacilli,1ZN8F@1386|Bacillus	91061|Bacilli	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4089532_3	1396418.BATQ01000147_gene3608	5.712e-98	328.0	COG1520@1|root,COG1520@2|Bacteria,46U89@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
CMS3_k127_4089532_5	314230.DSM3645_18931	3.757e-16	84.0	2EJH6@1|root,33D83@2|Bacteria,2J1HK@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF3311)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3311
CMS3_k127_4089532_0	314230.DSM3645_18936	2.304e-161	523.0	COG0591@1|root,COG0591@2|Bacteria,2IY5N@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS3_k127_4089532_1	497964.CfE428DRAFT_5033	1.649e-159	536.0	COG1541@1|root,COG1541@2|Bacteria,46UFN@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4089532_2	631362.Thi970DRAFT_04530	8.27e-143	464.0	28JVF@1|root,2Z9KD@2|Bacteria,1MXZ6@1224|Proteobacteria,1RY7E@1236|Gammaproteobacteria,1WX1M@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4089532_4	335543.Sfum_1630	5.998e-31	137.0	28HJ1@1|root,2Z7UB@2|Bacteria,1R3FN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4089853_2	452637.Oter_2576	3.777e-54	195.0	COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,46SG1@74201|Verrucomicrobia,3K7GH@414999|Opitutae	414999|Opitutae	IM	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	fabZ	-	3.5.1.108,4.2.1.59	ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	M00060,M00083	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	-	-	-	FabA,LpxC
CMS3_k127_4089853_1	525897.Dbac_3377	5.085e-67	239.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2WJVP@28221|Deltaproteobacteria,2M9DB@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
CMS3_k127_4089853_0	247490.KSU1_B0556	2.345e-85	304.0	COG0673@1|root,COG0673@2|Bacteria,2IXAX@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_4089853_3	237368.SCABRO_01481	4.57e-18	98.0	COG1376@1|root,COG1376@2|Bacteria,2J0C4@203682|Planctomycetes	203682|Planctomycetes	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,YkuD
CMS3_k127_4089853_5	1123371.ATXH01000052_gene627	0.0001847	45.0	2DTS4@1|root,33MFD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4093364_0	204669.Acid345_2477	4.839e-49	181.0	COG0476@1|root,COG0476@2|Bacteria,3Y2HZ@57723|Acidobacteria,2JHXP@204432|Acidobacteriia	204432|Acidobacteriia	H	MoeZ MoeB	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
CMS3_k127_409423_2	1501230.ET33_14910	3.502e-19	95.0	COG0745@1|root,COG0745@2|Bacteria,1VAYR@1239|Firmicutes,4HKT2@91061|Bacilli,26XHT@186822|Paenibacillaceae	91061|Bacilli	KT	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS3_k127_409423_1	237368.SCABRO_00821	1.488e-32	128.0	COG0234@1|root,COG0234@2|Bacteria,2J027@203682|Planctomycetes	203682|Planctomycetes	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	-	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
CMS3_k127_409423_0	886293.Sinac_1042	4.247e-223	704.0	COG0459@1|root,COG0459@2|Bacteria,2IXA7@203682|Planctomycetes	203682|Planctomycetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS3_k127_4096066_1	518766.Rmar_1489	2.133e-16	87.0	COG4636@1|root,COG4636@2|Bacteria,4NNM9@976|Bacteroidetes	976|Bacteroidetes	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
CMS3_k127_4096066_2	1122135.KB893170_gene2664	6.471e-13	73.0	COG5460@1|root,COG5460@2|Bacteria,1NQ45@1224|Proteobacteria	1224|Proteobacteria	S	Uncharacterized conserved protein (DUF2164)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2164
CMS3_k127_4096066_0	234267.Acid_5391	8.532e-108	355.0	COG2609@1|root,COG2609@2|Bacteria,3Y2M3@57723|Acidobacteria	57723|Acidobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
CMS3_k127_4096911_4	289376.THEYE_A0473	2.821e-62	222.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	5.1.3.10,5.1.3.2	ko:K01784,ko:K12454	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984,R04266	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
CMS3_k127_4096911_2	1121438.JNJA01000001_gene2277	1.314e-93	319.0	COG1215@1|root,COG1215@2|Bacteria,1QVXA@1224|Proteobacteria,43CYF@68525|delta/epsilon subdivisions,2X8B0@28221|Deltaproteobacteria,2MAXN@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_4096911_3	557599.MKAN_27390	3.273e-78	269.0	COG0500@1|root,COG1215@1|root,COG1215@2|Bacteria,COG2226@2|Bacteria,2IBMN@201174|Actinobacteria,239CX@1762|Mycobacteriaceae	201174|Actinobacteria	MQ	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_11
CMS3_k127_4096911_0	344747.PM8797T_00899	7.553e-185	591.0	COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes	203682|Planctomycetes	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
CMS3_k127_4096911_5	469617.FUAG_02624	5.626e-28	122.0	2AW5K@1|root,31N0K@2|Bacteria,37AC3@32066|Fusobacteria	32066|Fusobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4096911_1	344747.PM8797T_15676	1.008e-164	531.0	COG0726@1|root,COG1413@1|root,COG2133@1|root,COG3474@1|root,COG0726@2|Bacteria,COG1413@2|Bacteria,COG2133@2|Bacteria,COG3474@2|Bacteria,2IXJQ@203682|Planctomycetes	203682|Planctomycetes	C	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,HEAT_2,VCBS
CMS3_k127_410966_0	1415779.JOMH01000001_gene76	2.835e-73	255.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	mntH	-	-	-	-	-	-	-	-	-	-	-	Nramp
CMS3_k127_4111982_3	1217705.F900_01351	3.467e-08	60.0	2CC9Y@1|root,33CPU@2|Bacteria,1NKBZ@1224|Proteobacteria,1TNC3@1236|Gammaproteobacteria,3NQBM@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4111982_5	102232.GLO73106DRAFT_00020540	2.493e-05	53.0	2EGZK@1|root,33ARQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4111982_2	211165.AJLN01000141_gene2456	1.764e-08	59.0	COG2886@1|root,COG2886@2|Bacteria,1G8EZ@1117|Cyanobacteria	1117|Cyanobacteria	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
CMS3_k127_4111982_0	761193.Runsl_4980	4.761e-83	289.0	COG1373@1|root,COG1373@2|Bacteria,4NEMX@976|Bacteroidetes,47MKR@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS3_k127_4111982_4	1174504.AJTN02000120_gene4835	6.434e-06	48.0	2BR4S@1|root,32K2S@2|Bacteria,1U1SU@1239|Firmicutes,4IB95@91061|Bacilli,1ZKR2@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4111982_6	1122176.KB903538_gene1446	0.0003281	53.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_4112666_4	518766.Rmar_0416	3.134e-41	157.0	COG1132@1|root,COG1132@2|Bacteria,4NDY6@976|Bacteroidetes,1FIKV@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	V	ABC transporter transmembrane region	mdlA	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
CMS3_k127_4112666_2	671143.DAMO_2494	1.568e-116	402.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	MdlB	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_4112666_1	886293.Sinac_5718	2.533e-156	506.0	COG3119@1|root,COG3119@2|Bacteria,2IYNT@203682|Planctomycetes	203682|Planctomycetes	P	Sulfatase	-	-	3.1.6.12	ko:K01135	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00076,M00077	R07823	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
CMS3_k127_4112666_3	1128421.JAGA01000001_gene2269	2.732e-101	339.0	COG1028@1|root,COG1028@2|Bacteria,2NQB4@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_4112666_5	1336245.JAGO01000011_gene269	2.393e-23	108.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,1S8G8@1236|Gammaproteobacteria,1XKAX@135619|Oceanospirillales	135619|Oceanospirillales	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS3_k127_4112666_0	237368.SCABRO_01759	1.033e-214	683.0	COG1217@1|root,COG1217@2|Bacteria,2IY3Q@203682|Planctomycetes	203682|Planctomycetes	T	membrane GTPase involved in stress response	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
CMS3_k127_4124664_3	1379270.AUXF01000001_gene1941	4.517e-67	247.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZUHA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
CMS3_k127_4124664_5	1183438.GKIL_3396	2.144e-36	144.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
CMS3_k127_4124664_2	644968.DFW101_2543	2.613e-73	260.0	COG3503@1|root,COG3503@2|Bacteria,1QQ9D@1224|Proteobacteria,431ME@68525|delta/epsilon subdivisions,2WWTB@28221|Deltaproteobacteria,2MC5V@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
CMS3_k127_4124664_1	550540.Fbal_0627	1.718e-77	274.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	aminopeptidase	pepP	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
CMS3_k127_4124664_0	1123242.JH636436_gene121	4.055e-148	514.0	COG4122@1|root,COG4122@2|Bacteria,2IXSM@203682|Planctomycetes	203682|Planctomycetes	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4124664_4	1210884.HG799470_gene14472	4.287e-52	197.0	2E0D2@1|root,32VZX@2|Bacteria,2J33D@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4124664_6	29875.EHK23312	1.149e-13	82.0	COG1404@1|root,KOG4266@2759|Eukaryota,38HI5@33154|Opisthokonta,3NWUG@4751|Fungi,3QQXB@4890|Ascomycota,211WR@147550|Sordariomycetes,3TETS@5125|Hypocreales,3TZC4@5129|Hypocreaceae	4751|Fungi	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,fn3_5
CMS3_k127_4125200_0	269799.Gmet_1965	7.292e-110	389.0	COG3868@1|root,COG3868@2|Bacteria,1NXBJ@1224|Proteobacteria,430FT@68525|delta/epsilon subdivisions,2WVXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4125200_3	1128421.JAGA01000001_gene2335	5.324e-21	107.0	COG2244@1|root,COG2244@2|Bacteria,2NRKQ@2323|unclassified Bacteria	2|Bacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C,Wzy_C
CMS3_k127_4125200_1	644968.DFW101_0126	3.051e-58	221.0	COG0438@1|root,COG0438@2|Bacteria,1MUTA@1224|Proteobacteria,42M2P@68525|delta/epsilon subdivisions,2WM2M@28221|Deltaproteobacteria,2MD72@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_4125200_2	1268237.G114_17025	6.426e-39	152.0	COG0438@1|root,COG0438@2|Bacteria,1MVR6@1224|Proteobacteria,1RQPT@1236|Gammaproteobacteria,1Y6HP@135624|Aeromonadales	135624|Aeromonadales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_4135399_2	595460.RRSWK_00970	2.155e-14	81.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c,HATPase_c_2
CMS3_k127_4135399_1	575540.Isop_0604	4.854e-70	257.0	COG0400@1|root,COG0400@2|Bacteria,2IZ0J@203682|Planctomycetes	203682|Planctomycetes	S	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4135399_0	1267535.KB906767_gene447	3.202e-112	396.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria,2JMN2@204432|Acidobacteriia	204432|Acidobacteriia	T	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
CMS3_k127_4135399_3	1173023.KE650771_gene4830	6.433e-07	61.0	COG1413@1|root,COG1413@2|Bacteria,1G511@1117|Cyanobacteria,1JJSP@1189|Stigonemataceae	1117|Cyanobacteria	C	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS3_k127_4152479_5	665571.STHERM_c14200	0.0003492	51.0	COG1033@1|root,COG1033@2|Bacteria,2J636@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS3_k127_4152479_4	378806.STAUR_1360	1.392e-05	57.0	COG2353@1|root,COG2353@2|Bacteria,1Q3RK@1224|Proteobacteria,439JF@68525|delta/epsilon subdivisions,2X4W2@28221|Deltaproteobacteria,2YZQD@29|Myxococcales	28221|Deltaproteobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
CMS3_k127_4152479_1	639030.JHVA01000001_gene3238	1.307e-115	390.0	COG3424@1|root,COG3424@2|Bacteria,3Y37E@57723|Acidobacteria,2JHXK@204432|Acidobacteriia	204432|Acidobacteriia	Q	FAE1/Type III polyketide synthase-like protein	-	-	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
CMS3_k127_4152479_0	313628.LNTAR_18530	3.955e-127	429.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	-	-	-	ko:K06610,ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1,2.A.1.1.27	-	-	MFS_1
CMS3_k127_4152479_2	1122603.ATVI01000009_gene2661	6.562e-21	101.0	COG3453@1|root,COG3453@2|Bacteria,1N0WC@1224|Proteobacteria,1S8TP@1236|Gammaproteobacteria,1X7C3@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative phosphatase (DUF442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
CMS3_k127_4152479_3	1125863.JAFN01000001_gene1129	2.28e-16	85.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2WJ76@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
CMS3_k127_4153534_2	596151.DesfrDRAFT_3252	3.503e-19	97.0	COG2974@1|root,COG2974@2|Bacteria,1RCUH@1224|Proteobacteria,42QVW@68525|delta/epsilon subdivisions,2WPFY@28221|Deltaproteobacteria,2MBIF@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	May be involved in recombination	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4153534_3	439235.Dalk_3853	5.675e-12	74.0	COG2974@1|root,COG2974@2|Bacteria,1N4GC@1224|Proteobacteria,42RPT@68525|delta/epsilon subdivisions,2WQUM@28221|Deltaproteobacteria,2MJSD@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Putative exonuclease, RdgC	-	-	-	-	-	-	-	-	-	-	-	-	RdgC
CMS3_k127_4153534_0	330214.NIDE0836	1.399e-292	917.0	COG1048@1|root,COG1048@2|Bacteria,3J0E6@40117|Nitrospirae	40117|Nitrospirae	C	Aconitase C-terminal domain	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
CMS3_k127_4153534_1	247490.KSU1_B0539	3.499e-28	131.0	COG2078@1|root,COG2078@2|Bacteria,2J349@203682|Planctomycetes	203682|Planctomycetes	S	AMMECR1	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1
CMS3_k127_4156487_0	1129794.C427_1223	6.272e-97	353.0	COG2706@1|root,COG3391@1|root,COG3637@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,COG3637@2|Bacteria,1QWRQ@1224|Proteobacteria,1T4S3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_415782_4	1173026.Glo7428_4675	2.103e-55	204.0	COG3153@1|root,COG3153@2|Bacteria,1G3A1@1117|Cyanobacteria	1117|Cyanobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
CMS3_k127_415782_2	338963.Pcar_0515	6.157e-105	350.0	COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,42NVQ@68525|delta/epsilon subdivisions,2WJFT@28221|Deltaproteobacteria,43TVE@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
CMS3_k127_415782_1	313628.LNTAR_05111	1.259e-124	407.0	COG0039@1|root,COG0039@2|Bacteria	2|Bacteria	C	L-malate dehydrogenase activity	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0030312,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
CMS3_k127_415782_3	517418.Ctha_1969	2.017e-69	239.0	COG0377@1|root,COG0377@2|Bacteria,1FF0H@1090|Chlorobi	1090|Chlorobi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
CMS3_k127_415782_0	1519464.HY22_07040	6.059e-132	439.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1FEF9@1090|Chlorobi	1090|Chlorobi	C	electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO
CMS3_k127_416136_1	378806.STAUR_8043	3.433e-132	423.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,42M1Y@68525|delta/epsilon subdivisions,2WP4Z@28221|Deltaproteobacteria,2YU7V@29|Myxococcales	28221|Deltaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.1.53,3.5.1.6	ko:K01431,ko:K12251	ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100	M00046	R00905,R01152,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
CMS3_k127_416136_0	1254432.SCE1572_37920	1.775e-175	562.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,42MVJ@68525|delta/epsilon subdivisions,2WKM4@28221|Deltaproteobacteria,2YUP4@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_416136_2	1279038.KB907345_gene3365	1.03e-14	79.0	COG2207@1|root,COG3449@1|root,COG2207@2|Bacteria,COG3449@2|Bacteria,1MWTF@1224|Proteobacteria,2TRY4@28211|Alphaproteobacteria,2JU28@204441|Rhodospirillales	204441|Rhodospirillales	K	Bacterial transcription activator, effector binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,HTH_18
CMS3_k127_416136_3	1122929.KB908217_gene109	4.816e-06	60.0	COG3449@1|root,COG4977@1|root,COG3449@2|Bacteria,COG4977@2|Bacteria,1QTW6@1224|Proteobacteria,2TXDF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator, araC family	-	-	-	ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18
CMS3_k127_4162425_3	1288298.rosmuc_01916	3.755e-15	78.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2TTY5@28211|Alphaproteobacteria,46ND8@74030|Roseovarius	28211|Alphaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_4162425_2	309807.SRU_2769	8.691e-17	83.0	COG2128@1|root,COG2128@2|Bacteria,4NN22@976|Bacteroidetes,1FK4T@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	PA26 p53-induced protein (sestrin)	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_4162425_0	756272.Plabr_4000	1.328e-31	135.0	2ADBE@1|root,3130V@2|Bacteria,2IZYT@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4162425_1	497964.CfE428DRAFT_3013	3.399e-24	108.0	2E6X2@1|root,331GI@2|Bacteria,46T38@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_417620_1	1121859.KB890750_gene101	1.794e-113	373.0	COG0492@1|root,COG0492@2|Bacteria,4NEVX@976|Bacteroidetes,47JQX@768503|Cytophagia	976|Bacteroidetes	C	Thioredoxin reductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
CMS3_k127_417620_5	1121033.AUCF01000003_gene3198	1.169e-12	72.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria,2JTUR@204441|Rhodospirillales	204441|Rhodospirillales	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
CMS3_k127_417620_3	1122621.ATZA01000009_gene289	3.016e-57	208.0	COG1131@1|root,COG1131@2|Bacteria,4NJ0D@976|Bacteroidetes,1IQ6J@117747|Sphingobacteriia	976|Bacteroidetes	V	SMART ATPase, AAA type, core	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_417620_0	1385510.N781_13005	4.119e-123	405.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,4H9S1@91061|Bacilli,2Y8US@289201|Pontibacillus	91061|Bacilli	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
CMS3_k127_417620_4	521045.Kole_1946	1.582e-28	124.0	COG0720@1|root,COG0720@2|Bacteria,2GD1V@200918|Thermotogae	200918|Thermotogae	H	PFAM 6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
CMS3_k127_417620_2	1121861.KB899942_gene3833	2.769e-70	252.0	COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,2TR88@28211|Alphaproteobacteria,2JRK0@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
CMS3_k127_4180735_0	234267.Acid_7828	5.285e-220	714.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS3_k127_4180735_1	102232.GLO73106DRAFT_00004400	9.808e-10	67.0	COG2931@1|root,COG2931@2|Bacteria,1G2GC@1117|Cyanobacteria	1117|Cyanobacteria	Q	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP
CMS3_k127_4181133_1	483219.LILAB_28020	1.035e-25	114.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Kelch_1,Kelch_3,Kelch_4,NHL
CMS3_k127_4181133_0	525904.Tter_0568	6.179e-98	336.0	COG0247@1|root,COG0247@2|Bacteria,2NNXS@2323|unclassified Bacteria	2|Bacteria	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_17,Fer4_7,Fer4_8
CMS3_k127_4181133_2	479432.Sros_2259	5.646e-19	99.0	COG0277@1|root,COG0277@2|Bacteria,2H3K3@201174|Actinobacteria,4EGYG@85012|Streptosporangiales	201174|Actinobacteria	C	FAD binding domain	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
CMS3_k127_4183221_0	555088.DealDRAFT_2207	2.621e-99	335.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,42K3W@68298|Syntrophomonadaceae	186801|Clostridia	L	DnaB-like helicase N terminal domain	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
CMS3_k127_4183221_4	521674.Plim_2625	2.461e-28	121.0	COG0359@1|root,COG0359@2|Bacteria,2IZCC@203682|Planctomycetes	203682|Planctomycetes	J	Binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
CMS3_k127_4183221_6	100901.wOo_09150	8.852e-11	65.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2UWYU@28211|Alphaproteobacteria,47GRM@766|Rickettsiales	766|Rickettsiales	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
CMS3_k127_4183221_5	575540.Isop_2891	7.163e-21	98.0	COG0360@1|root,COG0360@2|Bacteria,2J0U0@203682|Planctomycetes	203682|Planctomycetes	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
CMS3_k127_4183221_2	498761.HM1_0724	1.202e-43	168.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia	186801|Clostridia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
CMS3_k127_4183221_3	247490.KSU1_B0545	5.999e-32	134.0	COG1825@1|root,COG1825@2|Bacteria,2J050@203682|Planctomycetes	203682|Planctomycetes	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
CMS3_k127_4183221_1	1123371.ATXH01000007_gene554	9.537e-79	269.0	COG0462@1|root,COG0462@2|Bacteria,2GGWM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
CMS3_k127_4184147_3	933262.AXAM01000013_gene1296	4.362e-53	202.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2MID0@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	TIGRFAM type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
CMS3_k127_4184147_7	207559.Dde_1090	4.619e-16	82.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,42V5C@68525|delta/epsilon subdivisions,2WRC4@28221|Deltaproteobacteria,2MD9P@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	TIGRFAM phosphocarrier, HPr family	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
CMS3_k127_4184147_6	1408303.JNJJ01000022_gene4704	3.88e-18	92.0	COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,1TPKU@1239|Firmicutes,4H9KR@91061|Bacilli,1ZAVB@1386|Bacillus	91061|Bacilli	GT	COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)	fruA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563	2.7.1.202	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
CMS3_k127_4184147_8	90814.KL370891_gene498	9.914e-06	58.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,46133@72273|Thiotrichales	72273|Thiotrichales	J	Sigma 54 modulation protein	yhbH	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
CMS3_k127_4184147_2	1304880.JAGB01000003_gene1178	6.802e-58	210.0	COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia	186801|Clostridia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
CMS3_k127_4184147_0	1121430.JMLG01000009_gene434	3.026e-76	273.0	COG1508@1|root,COG1508@2|Bacteria,1TQ0H@1239|Firmicutes,2480F@186801|Clostridia,260B1@186807|Peptococcaceae	186801|Clostridia	K	TIGRFAM RNA polymerase sigma-54 factor	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
CMS3_k127_4184147_4	767817.Desgi_0066	4.553e-48	180.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,2612W@186807|Peptococcaceae	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
CMS3_k127_4184147_5	555079.Toce_2147	2.543e-24	107.0	COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,42GRS@68295|Thermoanaerobacterales	186801|Clostridia	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
CMS3_k127_4184147_1	1203606.HMPREF1526_00508	5.296e-68	251.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,36DBN@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
CMS3_k127_4187467_0	330214.NIDE3701	1.314e-104	350.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
CMS3_k127_4187467_1	1487953.JMKF01000004_gene647	1.37e-33	133.0	COG0599@1|root,COG0599@2|Bacteria,1G8UR@1117|Cyanobacteria	1117|Cyanobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_4217246_2	1122138.AQUZ01000014_gene7095	1.288e-08	64.0	COG1595@1|root,COG1595@2|Bacteria,2GJER@201174|Actinobacteria,4DPVS@85009|Propionibacteriales	201174|Actinobacteria	K	ECF sigma factor	adsA	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_4217246_1	1049564.TevJSym_af00110	9.871e-59	214.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RZYT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Peptidase M48	-	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
CMS3_k127_4217246_0	1123242.JH636436_gene238	1.528e-64	242.0	COG1807@1|root,COG1807@2|Bacteria,2J18J@203682|Planctomycetes	203682|Planctomycetes	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_4228449_0	1071073.KI530537_gene1542	2.717e-19	98.0	COG4262@1|root,COG4262@2|Bacteria,1UHSI@1239|Firmicutes,4HAWQ@91061|Bacilli,1ZBZ0@1386|Bacillus	91061|Bacilli	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
CMS3_k127_4250183_1	504472.Slin_5637	6.039e-146	481.0	COG0626@1|root,COG0626@2|Bacteria,4NF0Q@976|Bacteroidetes,47JY2@768503|Cytophagia	976|Bacteroidetes	E	PFAM Cys Met metabolism PLP-dependent enzyme	metC	-	2.5.1.48,4.4.1.1,4.4.1.8	ko:K01739,ko:K01758,ko:K01760	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
CMS3_k127_4250183_2	388413.ALPR1_00680	2.853e-115	395.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,Phytase-like
CMS3_k127_4250183_0	1121104.AQXH01000003_gene329	3.444e-221	704.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,DUF1566,LVIVD,Pec_lyase_C,Pectinesterase
CMS3_k127_4250183_3	1192034.CAP_4867	7.242e-10	72.0	COG1413@1|root,COG1413@2|Bacteria,1N55Z@1224|Proteobacteria,42Q7F@68525|delta/epsilon subdivisions,2WPWV@28221|Deltaproteobacteria,2YU62@29|Myxococcales	28221|Deltaproteobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT,HEAT_2,HEAT_PBS
CMS3_k127_4258521_2	886293.Sinac_4629	1.188e-128	425.0	COG0673@1|root,COG0673@2|Bacteria,2IWX9@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_4258521_1	794903.OPIT5_28790	4.529e-179	580.0	COG1132@1|root,COG1132@2|Bacteria,46UPX@74201|Verrucomicrobia,3K7GE@414999|Opitutae	414999|Opitutae	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_4258521_0	278957.ABEA03000215_gene4261	6.165e-200	639.0	COG1132@1|root,COG1132@2|Bacteria,46UY5@74201|Verrucomicrobia,3K7GK@414999|Opitutae	414999|Opitutae	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_4267492_0	886293.Sinac_7498	1.507e-137	450.0	COG2010@1|root,COG2010@2|Bacteria,2IXZ4@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
CMS3_k127_4277444_1	573370.DMR_45890	3.152e-78	277.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,42R77@68525|delta/epsilon subdivisions,2WMVR@28221|Deltaproteobacteria,2MAKU@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Integral membrane sensor signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_4277444_0	909663.KI867150_gene2391	1.058e-84	289.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,42N90@68525|delta/epsilon subdivisions,2WJUU@28221|Deltaproteobacteria,2MRIT@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_4277444_2	3750.XP_008384347.1	0.0001459	55.0	2CN1Q@1|root,2QTBJ@2759|Eukaryota,37UBQ@33090|Viridiplantae,3GHXQ@35493|Streptophyta,4JS4R@91835|fabids	35493|Streptophyta	S	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase2
CMS3_k127_4283172_3	1142394.PSMK_02370	6.404e-31	135.0	COG2928@1|root,COG2928@2|Bacteria,2IZGR@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
CMS3_k127_4283172_1	1123242.JH636435_gene1670	8.495e-71	250.0	COG0568@1|root,COG0568@2|Bacteria,2IYCB@203682|Planctomycetes	203682|Planctomycetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS3_k127_4283172_0	1123267.JONN01000001_gene656	5.648e-80	281.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2TT63@28211|Alphaproteobacteria,2K09I@204457|Sphingomonadales	204457|Sphingomonadales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS3_k127_4283172_2	309801.trd_1481	1.355e-55	205.0	COG0639@1|root,COG0639@2|Bacteria,2G6GC@200795|Chloroflexi,27Y5S@189775|Thermomicrobia	189775|Thermomicrobia	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
CMS3_k127_428520_1	583355.Caka_1800	7.382e-36	147.0	COG2042@1|root,COG2042@2|Bacteria	2|Bacteria	S	rRNA processing	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	DTW,Ribo_biogen_C
CMS3_k127_428520_0	237368.SCABRO_01688	8.843e-47	183.0	COG0859@1|root,COG0859@2|Bacteria,2IYZS@203682|Planctomycetes	203682|Planctomycetes	M	COG0859 ADP-heptose LPS heptosyltransferase	-	-	-	ko:K02841,ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS3_k127_428520_2	243277.VC_0227	3.402e-15	87.0	COG3642@1|root,COG3642@2|Bacteria,1RDW7@1224|Proteobacteria,1S46R@1236|Gammaproteobacteria,1XT1W@135623|Vibrionales	135623|Vibrionales	H	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position	kdkA	-	2.7.1.166	ko:K11211	ko00540,map00540	-	R09767	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Kdo
CMS3_k127_428520_3	530564.Psta_1283	1.55e-07	57.0	COG3682@1|root,COG3682@2|Bacteria,2J00G@203682|Planctomycetes	203682|Planctomycetes	K	penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS3_k127_428997_1	1298858.AUEL01000019_gene3178	0.0003798	44.0	COG0210@1|root,COG0210@2|Bacteria,1MZGR@1224|Proteobacteria,2TSRX@28211|Alphaproteobacteria,43R92@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	IrrE N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,Peptidase_M78,UvrD-helicase,UvrD_C
CMS3_k127_428997_0	290397.Adeh_3877	1.72e-115	395.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1QYGN@1224|Proteobacteria,43CCX@68525|delta/epsilon subdivisions,2WXED@28221|Deltaproteobacteria,2YZUY@29|Myxococcales	28221|Deltaproteobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
CMS3_k127_4292142_0	1382306.JNIM01000001_gene1561	2.143e-254	810.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2G64C@200795|Chloroflexi	200795|Chloroflexi	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
CMS3_k127_4295073_3	479434.Sthe_2396	5.239e-76	288.0	COG1807@1|root,COG1807@2|Bacteria,2G85B@200795|Chloroflexi	200795|Chloroflexi	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_4295073_0	1089551.KE386572_gene3637	1.907e-268	839.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,4BRH2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EG	Dehydratase family	-	-	4.2.1.25	ko:K13875	ko00053,ko01100,map00053,map01100	-	R02522	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
CMS3_k127_4295073_2	1089552.KI911559_gene1070	1.916e-86	304.0	COG3386@1|root,COG3386@2|Bacteria,1MWTR@1224|Proteobacteria,2TUTF@28211|Alphaproteobacteria,2JSIT@204441|Rhodospirillales	204441|Rhodospirillales	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
CMS3_k127_4295073_1	1040983.AXAE01000001_gene2804	7.667e-93	311.0	COG1028@1|root,COG1028@2|Bacteria,1MXTP@1224|Proteobacteria,2TQST@28211|Alphaproteobacteria,43N4Q@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	1.1.1.175	ko:K22185	ko00040,map00040	-	R01429	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
CMS3_k127_4316609_6	595460.RRSWK_02270	4.435e-43	177.0	COG1663@1|root,COG1663@2|Bacteria,2IXYX@203682|Planctomycetes	203682|Planctomycetes	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
CMS3_k127_4316609_3	1128398.Curi_c16330	4.918e-64	232.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,247UF@186801|Clostridia,268RX@186813|unclassified Clostridiales	186801|Clostridia	I	Acyl transferase domain	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
CMS3_k127_4316609_1	638302.HMPREF0908_1234	9.391e-109	378.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,4H27E@909932|Negativicutes	909932|Negativicutes	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
CMS3_k127_4316609_2	1192034.CAP_1671	1.106e-64	248.0	COG4284@1|root,COG4284@2|Bacteria,1Q5YI@1224|Proteobacteria,42QK5@68525|delta/epsilon subdivisions,2WKKW@28221|Deltaproteobacteria,2YVJD@29|Myxococcales	28221|Deltaproteobacteria	G	UTP--glucose-1-phosphate uridylyltransferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
CMS3_k127_4316609_5	290397.Adeh_3956	6.245e-44	168.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4316609_4	861299.J421_4225	2.482e-50	193.0	COG1141@1|root,COG1752@1|root,COG1141@2|Bacteria,COG1752@2|Bacteria,1ZT7Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	4Fe-4S single cluster domain	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Fer4_15,Patatin
CMS3_k127_4316609_0	1379698.RBG1_1C00001G0785	3.678e-136	449.0	COG1541@1|root,COG1541@2|Bacteria,2NREC@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
CMS3_k127_4316609_7	497964.CfE428DRAFT_5145	1.977e-16	93.0	COG0183@1|root,COG0183@2|Bacteria	2|Bacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_4317981_1	1131269.AQVV01000004_gene638	7.048e-83	279.0	COG1509@1|root,COG1509@2|Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
CMS3_k127_4317981_0	386415.NT01CX_0097	1.139e-185	590.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,36EGU@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_4317981_2	481448.Minf_0632	7.752e-05	54.0	COG4380@1|root,COG4380@2|Bacteria,46YUU@74201|Verrucomicrobia,37FYX@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Putative bacterial lipoprotein (DUF799)	-	-	-	-	-	-	-	-	-	-	-	-	DUF799
CMS3_k127_4322261_1	262724.TT_C0044	1.862e-18	90.0	COG0232@1|root,COG0232@2|Bacteria,1WI39@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Belongs to the dGTPase family. Type 2 subfamily	-	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
CMS3_k127_4322261_0	344747.PM8797T_24886	3.764e-22	108.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	1.11.1.7	ko:K19511	-	-	-	-	ko00000,ko01000	-	-	-	CAP,HemolysinCabind,Peptidase_M10_C,VCBS
CMS3_k127_4326327_6	886293.Sinac_4986	1.1e-19	102.0	COG0612@1|root,COG1595@1|root,COG0612@2|Bacteria,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088,ko:K07263	-	-	-	-	ko00000,ko01000,ko01002,ko03021	-	-	-	Peptidase_M16,Peptidase_M16_C,Sigma70_r2,Sigma70_r4_2
CMS3_k127_4326327_0	926550.CLDAP_11110	8.164e-138	445.0	COG4608@1|root,COG4608@2|Bacteria,2G5R5@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_4326327_1	1519464.HY22_11445	2.637e-122	419.0	COG0444@1|root,COG0444@2|Bacteria,1FDSN@1090|Chlorobi	1090|Chlorobi	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
CMS3_k127_4326327_4	290315.Clim_1543	2.168e-80	283.0	COG1173@1|root,COG1173@2|Bacteria,1FD9T@1090|Chlorobi	1090|Chlorobi	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
CMS3_k127_4326327_5	517417.Cpar_0557	1.787e-76	269.0	COG0601@1|root,COG0601@2|Bacteria,1FDDB@1090|Chlorobi	1090|Chlorobi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS3_k127_4326327_2	517417.Cpar_0556	2.566e-103	360.0	COG0747@1|root,COG0747@2|Bacteria,1FD6U@1090|Chlorobi	1090|Chlorobi	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_4326327_3	234267.Acid_5562	5.337e-87	303.0	COG4102@1|root,COG4102@2|Bacteria,3Y2YD@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_4337126_1	221288.JH992901_gene2529	3.872e-52	192.0	28VR5@1|root,2ZHT3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4337126_0	1123070.KB899255_gene1400	2.532e-318	1005.0	COG1404@1|root,COG1858@1|root,COG4257@1|root,COG1404@2|Bacteria,COG1858@2|Bacteria,COG4257@2|Bacteria,46U0N@74201|Verrucomicrobia,2IUGP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
CMS3_k127_4341899_0	237368.SCABRO_01840	2.244e-131	424.0	COG0624@1|root,COG1181@1|root,COG0624@2|Bacteria,COG1181@2|Bacteria,2IZEV@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
CMS3_k127_4341899_1	1121405.dsmv_0232	8.988e-111	378.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43BS9@68525|delta/epsilon subdivisions,2X733@28221|Deltaproteobacteria,2MPJG@213118|Desulfobacterales	28221|Deltaproteobacteria	K	sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
CMS3_k127_4341899_2	1038862.KB893833_gene4771	1.463e-108	359.0	COG3555@1|root,COG3555@2|Bacteria,1MW3M@1224|Proteobacteria,2TRVQ@28211|Alphaproteobacteria,3JUKX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Aspartyl/Asparaginyl beta-hydroxylase	MA20_07860	-	1.14.11.16	ko:K00476,ko:K12979	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Asp_Arg_Hydrox
CMS3_k127_4341899_3	323850.Shew_0815	1.848e-67	239.0	COG0363@1|root,COG0363@2|Bacteria,1MVEA@1224|Proteobacteria,1RQ2V@1236|Gammaproteobacteria,2QA22@267890|Shewanellaceae	1236|Gammaproteobacteria	G	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion	nagB	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso
CMS3_k127_4345225_2	498761.HM1_1110	2.906e-10	65.0	COG2385@1|root,COG2385@2|Bacteria,1TQSI@1239|Firmicutes,249H0@186801|Clostridia	186801|Clostridia	D	stage II sporulation protein D	spoIID	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
CMS3_k127_4345225_0	743720.Psefu_1120	1.424e-91	343.0	COG0457@1|root,COG0457@2|Bacteria	743720.Psefu_1120|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4345225_1	936375.HMPREF1152_0886	1.457e-23	102.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,3WCE9@538999|Clostridiales incertae sedis	186801|Clostridia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
CMS3_k127_4358318_0	740709.A10D4_00975	1.984e-51	205.0	COG1520@1|root,COG3209@1|root,COG3210@1|root,COG1520@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	yeeJ	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	CHU_C,Calx-beta,Flg_new,HYR,Laminin_G_3,PQQ_2
CMS3_k127_4358318_2	761193.Runsl_5373	5.022e-15	87.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4358318_3	215803.DB30_6554	9.03e-06	59.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF5011
CMS3_k127_4358318_1	1004149.AFOE01000017_gene784	9.927e-37	153.0	COG2374@1|root,COG2374@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS3_k127_4372614_3	1144319.PMI16_00665	1.191e-12	70.0	COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,2VS13@28216|Betaproteobacteria,473BT@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	haloacid dehalogenase-like hydrolase	gph	-	3.1.3.105	ko:K22292	ko00520,map00520	-	R11785	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS3_k127_4372614_2	867845.KI911784_gene1037	9.368e-28	128.0	COG0534@1|root,COG0534@2|Bacteria,2G78S@200795|Chloroflexi,375PA@32061|Chloroflexia	32061|Chloroflexia	V	PFAM multi antimicrobial extrusion protein MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS3_k127_4372614_0	521674.Plim_0286	1.263e-125	416.0	COG2960@1|root,COG2960@2|Bacteria,2IX87@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
CMS3_k127_4372614_1	886293.Sinac_6369	6.287e-64	225.0	COG0551@1|root,COG0551@2|Bacteria,2IXB2@203682|Planctomycetes	203682|Planctomycetes	L	Ca-dependent carbohydrate-binding module xylan-binding	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,Cytochrome_CBB3,PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5
CMS3_k127_437716_0	1403819.BATR01000027_gene884	4.428e-156	517.0	COG2133@1|root,COG2133@2|Bacteria,46UKF@74201|Verrucomicrobia,2IU1Q@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_437716_1	886293.Sinac_5787	1.082e-53	198.0	COG2010@1|root,COG3474@1|root,COG2010@2|Bacteria,COG3474@2|Bacteria,2IXIX@203682|Planctomycetes	203682|Planctomycetes	C	PFAM PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,DUF1080,PA14
CMS3_k127_4377626_0	667014.Thein_1907	2.382e-93	320.0	COG0123@1|root,COG0123@2|Bacteria,2GHD6@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
CMS3_k127_4377626_1	545694.TREPR_2811	3.41e-92	310.0	COG0708@1|root,COG0708@2|Bacteria,2J62E@203691|Spirochaetes	203691|Spirochaetes	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
CMS3_k127_4377626_3	644968.DFW101_1208	3.738e-36	148.0	COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,42QZX@68525|delta/epsilon subdivisions,2WN5T@28221|Deltaproteobacteria,2MA07@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
CMS3_k127_4377626_2	404589.Anae109_2716	3.553e-74	263.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,42R48@68525|delta/epsilon subdivisions,2WMAR@28221|Deltaproteobacteria,2YUR9@29|Myxococcales	28221|Deltaproteobacteria	E	MazG nucleotide pyrophosphohydrolase domain	mazG	-	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
CMS3_k127_4388871_2	595460.RRSWK_00745	3.231e-60	221.0	COG0577@1|root,COG0577@2|Bacteria,2IZAQ@203682|Planctomycetes	203682|Planctomycetes	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS3_k127_4388871_1	756272.Plabr_3127	8.035e-73	268.0	COG4591@1|root,COG4591@2|Bacteria,2IYEV@203682|Planctomycetes	203682|Planctomycetes	M	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_4388871_0	1403819.BATR01000083_gene2432	9.377e-75	275.0	COG1136@1|root,COG1136@2|Bacteria,46UUF@74201|Verrucomicrobia,2ITZH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS3_k127_4388871_3	530564.Psta_1227	6.542e-38	158.0	COG0845@1|root,COG0845@2|Bacteria,2IY6J@203682|Planctomycetes	203682|Planctomycetes	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS3_k127_4399718_2	1304878.AUGD01000006_gene6644	0.0005505	50.0	COG5266@1|root,COG5266@2|Bacteria,1R7XS@1224|Proteobacteria,2UGU8@28211|Alphaproteobacteria,3K34C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Domain of unknown function (DUF4198)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4198
CMS3_k127_4399718_0	234267.Acid_3219	4.984e-93	337.0	COG4447@1|root,COG4447@2|Bacteria,3Y4R8@57723|Acidobacteria	57723|Acidobacteria	O	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4399718_1	886293.Sinac_3605	2.702e-13	82.0	COG1657@1|root,COG1657@2|Bacteria,2IX8J@203682|Planctomycetes	203682|Planctomycetes	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4401463_2	362242.MUL_2084	8.615e-06	58.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,2GKDT@201174|Actinobacteria,2362R@1762|Mycobacteriaceae	201174|Actinobacteria	CO	biogenesis protein	dipZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD
CMS3_k127_4401463_0	530564.Psta_3753	3.025e-31	129.0	COG1595@1|root,COG1595@2|Bacteria,2J3KY@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_4401463_1	1123242.JH636435_gene2223	2.82e-13	76.0	COG1520@1|root,COG3391@1|root,COG1520@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114
CMS3_k127_4403720_2	500635.MITSMUL_03467	3.564e-88	306.0	COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,4H1WP@909932|Negativicutes	909932|Negativicutes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
CMS3_k127_4403720_4	247490.KSU1_C0961	1.424e-37	147.0	COG0613@1|root,COG0781@1|root,COG0613@2|Bacteria,COG0781@2|Bacteria,2J058@203682|Planctomycetes	203682|Planctomycetes	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB,PHP
CMS3_k127_4403720_3	935948.KE386495_gene1424	2.06e-56	205.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,24FRS@186801|Clostridia,42G01@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
CMS3_k127_4403720_0	314230.DSM3645_11507	1.399e-260	826.0	COG2010@1|root,COG2010@2|Bacteria,2IYQJ@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
CMS3_k127_4403720_1	314230.DSM3645_11502	1.618e-151	488.0	COG4102@1|root,COG4102@2|Bacteria,2IX70@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_4405304_1	309801.trd_1658	4.827e-12	78.0	COG2340@1|root,COG2340@2|Bacteria,2G8G6@200795|Chloroflexi,27XTT@189775|Thermomicrobia	189775|Thermomicrobia	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
CMS3_k127_4405304_0	123214.PERMA_0937	1.686e-13	83.0	COG3291@1|root,COG3291@2|Bacteria,2G57S@200783|Aquificae	200783|Aquificae	O	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
CMS3_k127_4406407_1	483219.LILAB_20115	1.981e-236	747.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,42QEW@68525|delta/epsilon subdivisions,2WJQI@28221|Deltaproteobacteria,2YU30@29|Myxococcales	28221|Deltaproteobacteria	L	DNA topoisomerase	parE	-	5.99.1.3	ko:K02470,ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
CMS3_k127_4406407_0	243090.RB3465	8.815e-260	816.0	COG0188@1|root,COG0188@2|Bacteria,2IXMT@203682|Planctomycetes	203682|Planctomycetes	L	COG0188 Type IIA topoisomerase (DNA gyrase topo II topoisomerase IV) A subunit	-	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CMS3_k127_4409320_0	493475.GARC_4265	6.289e-107	379.0	COG2931@1|root,COG2982@1|root,COG4733@1|root,COG2931@2|Bacteria,COG2982@2|Bacteria,COG4733@2|Bacteria,1MU7T@1224|Proteobacteria,1S1HJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,DUF4214,DUF4347,He_PIG,HemolysinCabind,PATR,VCBS
CMS3_k127_4409320_1	1125863.JAFN01000001_gene3478	2.233e-60	224.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,42MD4@68525|delta/epsilon subdivisions,2WJ7Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
CMS3_k127_4420602_1	404589.Anae109_0398	1.528e-07	65.0	COG4932@1|root,COG4932@2|Bacteria,1PYE0@1224|Proteobacteria,43E3U@68525|delta/epsilon subdivisions,2X97I@28221|Deltaproteobacteria,2Z2E0@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_4420602_0	1173027.Mic7113_1372	4.921e-99	336.0	COG0793@1|root,COG0793@2|Bacteria,1G30Q@1117|Cyanobacteria,1HA53@1150|Oscillatoriales	1117|Cyanobacteria	M	PDZ domain (Also known as DHR or GLGF)	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41,Tricorn_C1
CMS3_k127_4439423_3	886293.Sinac_0065	1.346e-06	61.0	COG1413@1|root,COG1413@2|Bacteria,2IZWZ@203682|Planctomycetes	203682|Planctomycetes	C	Pretoxin HINT domain	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT
CMS3_k127_4439423_2	565653.EGBG_01025	4.896e-09	69.0	COG0652@1|root,COG0652@2|Bacteria,1V6A3@1239|Firmicutes,4HI5S@91061|Bacilli,4AZET@81852|Enterococcaceae	91061|Bacilli	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
CMS3_k127_4439423_0	1444309.JAQG01000013_gene1906	2.432e-56	209.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,4H9TB@91061|Bacilli,26RXG@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the ParB family	spo0J	GO:0005575,GO:0005622,GO:0005623,GO:0007059,GO:0008150,GO:0009295,GO:0009987,GO:0022603,GO:0042173,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0043937,GO:0043938,GO:0044424,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	HTH_3,KorB,ParBc
CMS3_k127_4439423_1	380394.Lferr_2816	3.34e-31	138.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,2NC43@225057|Acidithiobacillales	225057|Acidithiobacillales	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS3_k127_4445825_1	1122917.KB899662_gene2104	2.152e-108	358.0	COG0451@1|root,COG0451@2|Bacteria,1TPHV@1239|Firmicutes,4HCJR@91061|Bacilli,26SNR@186822|Paenibacillaceae	91061|Bacilli	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS3_k127_4445825_0	234267.Acid_0710	3.47e-132	430.0	COG0329@1|root,COG0329@2|Bacteria,3Y6I2@57723|Acidobacteria	57723|Acidobacteria	EM	Dihydrodipicolinate synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	DHDPS
CMS3_k127_4445825_2	1396141.BATP01000009_gene2648	6.931e-77	266.0	COG1082@1|root,COG1082@2|Bacteria,46V1E@74201|Verrucomicrobia,2IVJ7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
CMS3_k127_4445825_3	344747.PM8797T_09879	3.547e-35	137.0	COG1914@1|root,COG1914@2|Bacteria,2IZ88@203682|Planctomycetes	203682|Planctomycetes	P	Cytochrome ba3-putative manganese transport protein mntH	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
CMS3_k127_4455958_5	1027273.GZ77_00505	3.063e-31	134.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1XI8J@135619|Oceanospirillales	135619|Oceanospirillales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CMS3_k127_4455958_2	1304888.ATWF01000001_gene1353	5.867e-58	228.0	COG0793@1|root,COG0793@2|Bacteria,2GEK7@200930|Deferribacteres	200930|Deferribacteres	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
CMS3_k127_4455958_3	326427.Cagg_2842	3.58e-52	192.0	COG0315@1|root,COG0315@2|Bacteria,2G6PC@200795|Chloroflexi,375NJ@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
CMS3_k127_4455958_1	232348.ADXL01000093_gene403	5.823e-95	332.0	COG0136@1|root,COG0136@2|Bacteria,1G0E6@1117|Cyanobacteria,1GYKG@1129|Synechococcus	1117|Cyanobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
CMS3_k127_4455958_4	869210.Marky_0819	1.235e-33	136.0	COG0511@1|root,COG0511@2|Bacteria,1WJNN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
CMS3_k127_4455958_0	756272.Plabr_0466	7.029e-182	578.0	COG0439@1|root,COG0439@2|Bacteria,2IWZV@203682|Planctomycetes	203682|Planctomycetes	I	Biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
CMS3_k127_4461668_7	709991.Odosp_0307	3.227e-45	180.0	COG1295@1|root,COG1295@2|Bacteria,4NH0H@976|Bacteroidetes,2FP7P@200643|Bacteroidia,22WV5@171551|Porphyromonadaceae	976|Bacteroidetes	S	ribonuclease BN	yihY	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
CMS3_k127_4461668_8	518766.Rmar_1927	1.375e-23	108.0	COG0494@1|root,COG0494@2|Bacteria,4PI8R@976|Bacteroidetes,1FJBC@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
CMS3_k127_4461668_9	1149133.ppKF707_0355	6.455e-20	102.0	COG0491@1|root,COG0491@2|Bacteria,1R4FA@1224|Proteobacteria,1S1QD@1236|Gammaproteobacteria,1YE7Z@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_4461668_1	1385513.N780_13880	1.258e-118	394.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HA2A@91061|Bacilli,2Y8Z1@289201|Pontibacillus	91061|Bacilli	I	Acyl-CoA dehydrogenase	mmgC	-	-	ko:K18244	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_4461668_6	861299.J421_3347	2.45e-54	193.0	COG2185@1|root,COG2185@2|Bacteria,1ZTNN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
CMS3_k127_4461668_5	106370.Francci3_2170	6.356e-65	247.0	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria,4ERGH@85013|Frankiales	201174|Actinobacteria	E	TIGRFAM LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
CMS3_k127_4461668_2	1033739.CAEU01000009_gene2074	7.392e-117	387.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HAKV@91061|Bacilli,26DW2@186818|Planococcaceae	91061|Bacilli	I	Acyl-CoA dehydrogenase, middle domain	acdA	-	1.3.8.1,1.3.8.7	ko:K00248,ko:K00249	ko00071,ko00280,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_4461668_3	518766.Rmar_0752	2.654e-104	347.0	COG1250@1|root,COG1250@2|Bacteria,4NGU8@976|Bacteroidetes,1FJ15@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	hbd	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
CMS3_k127_4461668_0	1379698.RBG1_1C00001G1459	2.033e-139	453.0	COG0183@1|root,COG0183@2|Bacteria,2NNU9@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_4461668_4	65393.PCC7424_5194	7.943e-74	255.0	COG0177@1|root,COG0177@2|Bacteria,1G1VI@1117|Cyanobacteria,3KHKS@43988|Cyanothece	1117|Cyanobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
CMS3_k127_4471230_4	1150399.AQYK01000001_gene1596	0.0003645	49.0	2E4AX@1|root,32Z6K@2|Bacteria,2I15G@201174|Actinobacteria,4FQ9B@85023|Microbacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF2017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2017
CMS3_k127_4471230_1	1235457.C404_27050	3.911e-92	317.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,1JZUI@119060|Burkholderiaceae	28216|Betaproteobacteria	V	ABC transporter	ybhF_1	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_4471230_2	1232410.KI421422_gene2058	2.143e-46	188.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,42PXX@68525|delta/epsilon subdivisions,2WIMB@28221|Deltaproteobacteria,43S49@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	ABC-2 type transporter	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CMS3_k127_4471230_3	595460.RRSWK_02735	4.115e-44	164.0	COG0346@1|root,COG0346@2|Bacteria,2J357@203682|Planctomycetes	203682|Planctomycetes	E	Glyoxalase-like domain	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
CMS3_k127_4471230_0	1382359.JIAL01000001_gene1070	9.195e-228	718.0	COG4799@1|root,COG4799@2|Bacteria,3Y3SM@57723|Acidobacteria,2JIBH@204432|Acidobacteriia	204432|Acidobacteriia	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
CMS3_k127_4471241_0	247490.KSU1_D0384	2.305e-204	661.0	COG0653@1|root,COG0653@2|Bacteria,2IXIT@203682|Planctomycetes	203682|Planctomycetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
CMS3_k127_4471241_2	344747.PM8797T_01709	1.065e-76	277.0	COG1519@1|root,COG1519@2|Bacteria,2IYCJ@203682|Planctomycetes	203682|Planctomycetes	M	transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
CMS3_k127_4471241_1	1510531.JQJJ01000010_gene2050	6.574e-175	569.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,3JQP1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Domain of unknown function (DUF4070)	MA20_17485	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS3_k127_4486420_0	595460.RRSWK_03305	4.954e-136	461.0	COG3064@1|root,COG3064@2|Bacteria	2|Bacteria	M	translation initiation factor activity	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	-
CMS3_k127_4486420_2	593750.Metfor_1432	0.0002009	53.0	COG0110@1|root,arCOG01848@2157|Archaea	2157|Archaea	E	COG0110 Acetyltransferase (isoleucine patch superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
CMS3_k127_4486420_1	314271.RB2654_06439	1.201e-62	232.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2
CMS3_k127_4491183_1	1122939.ATUD01000001_gene577	1.622e-149	515.0	COG1520@1|root,COG1520@2|Bacteria,2H3K4@201174|Actinobacteria,4CRJK@84995|Rubrobacteria	84995|Rubrobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4491183_0	861299.J421_3227	3.278e-160	514.0	COG0334@1|root,COG0334@2|Bacteria,1ZSQB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_4491183_13	1112274.KI911560_gene171	5.262e-14	82.0	COG0515@1|root,COG0515@2|Bacteria,1MXX9@1224|Proteobacteria,2VHSR@28216|Betaproteobacteria,2KM93@206350|Nitrosomonadales	206350|Nitrosomonadales	KLT	Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core	-	-	-	ko:K02848	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Kdo
CMS3_k127_4491183_14	521045.Kole_0418	1.926e-09	71.0	COG2304@1|root,COG2304@2|Bacteria,2GDNS@200918|Thermotogae	200918|Thermotogae	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA
CMS3_k127_4491183_7	1232410.KI421413_gene857	1.673e-97	361.0	COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,42M9U@68525|delta/epsilon subdivisions,2WJ4X@28221|Deltaproteobacteria,43U2X@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Resolvase, RNase H domain protein fold	tex	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
CMS3_k127_4491183_10	237368.SCABRO_03066	3.633e-60	222.0	COG0859@1|root,COG0859@2|Bacteria,2IXD5@203682|Planctomycetes	203682|Planctomycetes	M	PFAM glycosyl transferase family 9	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS3_k127_4491183_16	1125863.JAFN01000001_gene1642	1.864e-06	62.0	COG1413@1|root,COG1413@2|Bacteria,1N55Z@1224|Proteobacteria,42Q7F@68525|delta/epsilon subdivisions,2WPWV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PBS lyase	-	-	-	-	-	-	-	-	-	-	-	-	HEAT,HEAT_2,HEAT_PBS
CMS3_k127_4491183_11	215803.DB30_8845	1.187e-25	118.0	2DGGC@1|root,2ZVVW@2|Bacteria,1P73E@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4491183_3	472759.Nhal_0313	1.7e-134	452.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1WX07@135613|Chromatiales	135613|Chromatiales	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
CMS3_k127_4491183_8	330214.NIDE0211	4.341e-81	280.0	COG3496@1|root,COG3496@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1365)	-	-	2.1.1.79	ko:K00574,ko:K09701	-	-	-	-	ko00000,ko01000	-	-	-	DUF1365
CMS3_k127_4491183_2	243231.GSU2327	1.946e-148	483.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,42N4S@68525|delta/epsilon subdivisions,2WJXX@28221|Deltaproteobacteria,43UK3@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
CMS3_k127_4491183_6	1121015.N789_06040	2.378e-111	369.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RM88@1236|Gammaproteobacteria,1X4PF@135614|Xanthomonadales	135614|Xanthomonadales	I	fatty acid desaturase	desC	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
CMS3_k127_4491183_9	1340493.JNIF01000004_gene1117	9.341e-72	251.0	COG3752@1|root,COG3752@2|Bacteria	2|Bacteria	M	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
CMS3_k127_4491183_5	1499967.BAYZ01000040_gene2249	4.774e-120	399.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	cfa	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
CMS3_k127_4491183_15	1173025.GEI7407_0581	1.502e-08	58.0	COG1225@1|root,COG1225@2|Bacteria,1G59X@1117|Cyanobacteria,1HAY7@1150|Oscillatoriales	1117|Cyanobacteria	O	Alkyl hydroperoxide reductase	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
CMS3_k127_4491183_12	1356852.N008_19460	1.11e-23	103.0	COG1225@1|root,COG1225@2|Bacteria,4NQCB@976|Bacteroidetes,47QFU@768503|Cytophagia	976|Bacteroidetes	O	PFAM AhpC TSA family	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
CMS3_k127_4491183_4	240016.ABIZ01000001_gene875	3.893e-127	422.0	COG1520@1|root,COG1520@2|Bacteria,46UCM@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_4495890_0	497964.CfE428DRAFT_4340	6.23e-160	512.0	COG3119@1|root,COG3119@2|Bacteria,46UNA@74201|Verrucomicrobia	74201|Verrucomicrobia	P	PFAM sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS3_k127_4495890_2	710696.Intca_0099	6.394e-77	268.0	COG4947@1|root,COG4947@2|Bacteria,2I9H9@201174|Actinobacteria,4FFF6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS3_k127_4495890_1	1385518.N798_16535	1.733e-114	383.0	COG0189@1|root,COG0189@2|Bacteria,2I5WV@201174|Actinobacteria,4FF3F@85021|Intrasporangiaceae	201174|Actinobacteria	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4495890_3	305900.GV64_19530	2.191e-45	167.0	COG3631@1|root,COG3631@2|Bacteria,1NI44@1224|Proteobacteria,1SYBF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
CMS3_k127_4502414_1	761193.Runsl_3208	4.318e-84	291.0	COG1913@1|root,COG1913@2|Bacteria,4PMAZ@976|Bacteroidetes,47JTT@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
CMS3_k127_4502414_0	469383.Cwoe_3280	1.353e-168	536.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4CPTW@84995|Rubrobacteria	84995|Rubrobacteria	C	Zinc-binding dehydrogenase	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_4502414_2	478741.JAFS01000001_gene1532	1.304e-70	246.0	COG1073@1|root,COG1073@2|Bacteria,46V25@74201|Verrucomicrobia,37G63@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Serine hydrolase (FSH1)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
CMS3_k127_4502414_3	1117958.PE143B_0105880	7.988e-15	85.0	COG3148@1|root,COG3148@2|Bacteria,1N8XY@1224|Proteobacteria,1RS6H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DTW domain containing protein	yfiP	-	-	ko:K05812	-	-	-	-	ko00000	-	-	-	DTW
CMS3_k127_4509815_0	472759.Nhal_3600	1.053e-87	298.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1WXKG@135613|Chromatiales	135613|Chromatiales	DM	mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
CMS3_k127_4509815_1	1177181.T9A_00660	1.671e-14	80.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria,1XJE3@135619|Oceanospirillales	135619|Oceanospirillales	M	Glycosyl transferase family 9	opsX	-	-	ko:K02849,ko:K12982	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS3_k127_451483_0	401526.TcarDRAFT_2158	1.441e-122	415.0	COG1063@1|root,COG1063@2|Bacteria,1U5GN@1239|Firmicutes	1239|Firmicutes	E	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_451483_1	1114970.PSF113_1046	1.047e-62	234.0	COG0457@1|root,COG0457@2|Bacteria,1RBMC@1224|Proteobacteria,1S33Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4516749_1	1121011.AUCB01000030_gene2159	5.252e-109	379.0	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,1HZHJ@117743|Flavobacteriia,23GZ2@178469|Arenibacter	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS3_k127_4516749_2	984962.XP_009547649.1	9.412e-21	102.0	KOG0118@1|root,KOG0118@2759|Eukaryota,3A0CS@33154|Opisthokonta,3P3AV@4751|Fungi,3V0WZ@5204|Basidiomycota,229J7@155619|Agaricomycetes,3H545@355688|Agaricomycetes incertae sedis	4751|Fungi	A	RNA-binding domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS3_k127_4516749_0	237368.SCABRO_03000	1.303e-139	460.0	COG1115@1|root,COG1115@2|Bacteria,2IX3I@203682|Planctomycetes	203682|Planctomycetes	U	COG1115 Na alanine symporter	dagA	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
CMS3_k127_4516749_3	1382304.JNIL01000001_gene3138	2.954e-14	82.0	COG0546@1|root,COG0546@2|Bacteria,1VH8M@1239|Firmicutes,4HP7G@91061|Bacilli	91061|Bacilli	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS3_k127_4523075_2	289377.HL41_01415	5.469e-52	200.0	COG0758@1|root,COG0758@2|Bacteria,2GHI2@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	LU	DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
CMS3_k127_4523075_0	344747.PM8797T_11094	0.0	1087.0	COG0542@1|root,COG0542@2|Bacteria,2IXHI@203682|Planctomycetes	203682|Planctomycetes	O	with chaperone activity ATP-binding	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
CMS3_k127_4523075_1	575540.Isop_3468	1.533e-89	314.0	COG3869@1|root,COG3869@2|Bacteria,2IXJG@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the specific phosphorylation of arginine residues in proteins	mcsB	-	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
CMS3_k127_4523075_3	580327.Tthe_0398	1.135e-22	106.0	COG3880@1|root,COG3880@2|Bacteria,1V6YM@1239|Firmicutes,24JE8@186801|Clostridia,42G0X@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM UvrB UvrC protein	mcsA	-	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
CMS3_k127_4523075_4	469383.Cwoe_3772	6.812e-11	68.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4CQ2K@84995|Rubrobacteria	84995|Rubrobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
CMS3_k127_453102_1	886293.Sinac_0924	5.764e-116	390.0	COG3119@1|root,COG3119@2|Bacteria,2IWX1@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.8	ko:K01134	ko00600,ko04142,map00600,map04142	-	R04856	RC00231	ko00000,ko00001,ko01000	-	-	-	DUF4994,Sulfatase
CMS3_k127_453102_2	1191523.MROS_0710	8.453e-78	284.0	COG0545@1|root,COG0652@1|root,COG2234@1|root,COG0545@2|Bacteria,COG0652@2|Bacteria,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	ppiC	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	FKBP_C,FKBP_N,Peptidase_M28,Pro_isomerase
CMS3_k127_453102_0	743720.Psefu_3739	4.773e-160	516.0	COG1262@1|root,COG1262@2|Bacteria,1PGT8@1224|Proteobacteria,1RX2J@1236|Gammaproteobacteria,1YZFA@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	ko:K20333	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	FGE-sulfatase
CMS3_k127_453102_3	743719.PaelaDRAFT_1447	2.114e-24	106.0	2D7FD@1|root,32TNY@2|Bacteria,1VADP@1239|Firmicutes,4HKCW@91061|Bacilli,26YY4@186822|Paenibacillaceae	91061|Bacilli	S	Molecular chaperone DnaJ	ydhN1	-	-	-	-	-	-	-	-	-	-	-	DUF1992
CMS3_k127_4531095_0	1487921.DP68_06575	7.446e-107	359.0	COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,36E1K@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
CMS3_k127_4538471_1	631362.Thi970DRAFT_00572	1.092e-57	228.0	COG0419@1|root,COG3264@1|root,COG0419@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1WXKG@135613|Chromatiales	135613|Chromatiales	DM	mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
CMS3_k127_4538471_0	595460.RRSWK_06264	3.826e-257	816.0	COG1073@1|root,COG1073@2|Bacteria,2IXPY@203682|Planctomycetes	203682|Planctomycetes	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2,Peptidase_S9
CMS3_k127_4541027_4	1396141.BATP01000003_gene5009	1.506e-55	212.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Calx-beta,He_PIG,Laminin_G_3,PKD,PPC,RHS_repeat
CMS3_k127_4541027_0	99598.Cal7507_5543	2.035e-170	546.0	COG1064@1|root,COG1064@2|Bacteria,1G0B9@1117|Cyanobacteria,1HMF1@1161|Nostocales	1117|Cyanobacteria	C	PFAM Alcohol dehydrogenase	-	-	-	ko:K12957,ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_4541027_1	886293.Sinac_5801	7.638e-100	335.0	COG2207@1|root,COG2207@2|Bacteria,2J1T9@203682|Planctomycetes	203682|Planctomycetes	K	PFAM AraC-type transcriptional regulator N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	AraC_N,HTH_18
CMS3_k127_4541027_2	404589.Anae109_3194	7.5e-96	321.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,42Q1N@68525|delta/epsilon subdivisions,2WK3A@28221|Deltaproteobacteria,2Z377@29|Myxococcales	28221|Deltaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	ygiD	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
CMS3_k127_4541027_3	1161401.ASJA01000001_gene369	2.086e-57	205.0	COG4430@1|root,COG4430@2|Bacteria,1RJGC@1224|Proteobacteria,2U3AS@28211|Alphaproteobacteria,4404V@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
CMS3_k127_4541027_5	1300345.LF41_3143	5.709e-12	66.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1X393@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	-	-	-	-	-	-	-	-	-	-	PALP
CMS3_k127_4546370_0	768710.DesyoDRAFT_3468	4.205e-130	423.0	COG1061@1|root,COG1061@2|Bacteria,1TPDM@1239|Firmicutes,24CK8@186801|Clostridia	186801|Clostridia	KL	Helicase conserved C-terminal domain	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
CMS3_k127_4546370_3	189426.PODO_12265	5.854e-05	56.0	2EDFC@1|root,33KX3@2|Bacteria,1VKNQ@1239|Firmicutes,4IRVY@91061|Bacilli,276XW@186822|Paenibacillaceae	91061|Bacilli	S	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
CMS3_k127_4546370_2	1122919.KB905575_gene3440	7.825e-23	106.0	COG0352@1|root,COG0352@2|Bacteria,1V6KJ@1239|Firmicutes,4HIM9@91061|Bacilli,26UZA@186822|Paenibacillaceae	91061|Bacilli	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	tenI	-	2.5.1.3,5.3.99.10	ko:K00788,ko:K10810	ko00730,ko01100,map00730,map01100	M00127	R03223,R09977,R10712	RC00224,RC02766,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	TMP-TENI
CMS3_k127_4546370_1	338963.Pcar_0028	5.714e-32	137.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,42MYJ@68525|delta/epsilon subdivisions,2WNGE@28221|Deltaproteobacteria,43U4D@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	AIR synthase related protein, C-terminal domain	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
CMS3_k127_4555531_0	338963.Pcar_2897	2.93e-105	348.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4555531_1	765420.OSCT_0910	3.268e-45	181.0	COG0457@1|root,COG1716@1|root,COG4447@1|root,COG0457@2|Bacteria,COG1716@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CarboxypepD_reg,FHA,Kelch_4,NHL,PA14,Peptidase_C11
CMS3_k127_4555969_0	237368.SCABRO_03724	2.694e-107	361.0	COG1389@1|root,COG1389@2|Bacteria,2J2A8@203682|Planctomycetes	203682|Planctomycetes	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
CMS3_k127_4555969_3	1210884.HG799462_gene8087	1.084e-31	134.0	COG1427@1|root,COG1427@2|Bacteria,2IYUW@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
CMS3_k127_4555969_5	81824.XP_001749811.1	0.000583	54.0	2ECT2@1|root,2SIJX@2759|Eukaryota,3A4NN@33154|Opisthokonta	33154|Opisthokonta	S	Carbohydrate esterase family 3 protein	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2,VCBS
CMS3_k127_4555969_2	575540.Isop_3510	4.972e-53	205.0	COG1801@1|root,COG1801@2|Bacteria,2IYWM@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
CMS3_k127_4555969_1	658187.LDG_6602	1.963e-74	262.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1JCNU@118969|Legionellales	118969|Legionellales	S	Belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
CMS3_k127_4555969_4	58123.JOFJ01000035_gene4645	2.453e-14	83.0	COG2866@1|root,COG3227@1|root,COG2866@2|Bacteria,COG3227@2|Bacteria,2I341@201174|Actinobacteria,4EQZU@85012|Streptosporangiales	201174|Actinobacteria	E	Fungalysin/Thermolysin Propeptide Motif	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
CMS3_k127_4565663_1	903818.KI912268_gene3204	4.721e-67	246.0	COG0577@1|root,COG0577@2|Bacteria,3Y4C7@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS3_k127_4565663_2	1266925.JHVX01000005_gene1916	1.853e-64	237.0	COG4591@1|root,COG4591@2|Bacteria,1QXNJ@1224|Proteobacteria,2WHVE@28216|Betaproteobacteria	28216|Betaproteobacteria	M	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_4565663_0	380358.XALC_0706	9.602e-85	286.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RSA2@1236|Gammaproteobacteria,1X3CK@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC transporter	tptC	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_4565663_3	1283300.ATXB01000001_gene36	3.049e-59	224.0	COG0845@1|root,COG0845@2|Bacteria,1MUMV@1224|Proteobacteria,1S0KD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
CMS3_k127_4565663_5	1499686.BN1079_01634	0.0003507	45.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the peptidase S1C family	degS	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564	-	ko:K04691,ko:K04772	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_4571900_0	391625.PPSIR1_20349	3.048e-06	60.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,PDZ_2
CMS3_k127_457405_0	469383.Cwoe_1561	1.61e-52	205.0	COG4262@1|root,COG4262@2|Bacteria,2HNDH@201174|Actinobacteria,4CP6G@84995|Rubrobacteria	84995|Rubrobacteria	S	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
CMS3_k127_457405_1	330214.NIDE1636	4.091e-09	69.0	COG4099@1|root,COG4099@2|Bacteria	2|Bacteria	F	phospholipase Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Abhydrolase_8,DLH,Esterase,Peptidase_S9
CMS3_k127_457405_2	1173028.ANKO01000116_gene5698	0.0003772	48.0	COG0457@1|root,COG0457@2|Bacteria,1G239@1117|Cyanobacteria,1H9NQ@1150|Oscillatoriales	1117|Cyanobacteria	S	Putative 2OG-Fe(II) oxygenase	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_5,TPR_1,TPR_10,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
CMS3_k127_4589521_2	1166018.FAES_5363	9.76e-13	71.0	COG1977@1|root,COG1977@2|Bacteria,4NUVK@976|Bacteroidetes,47RZY@768503|Cytophagia	976|Bacteroidetes	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
CMS3_k127_4589521_0	1227454.C446_16275	1.196e-78	275.0	arCOG06187@1|root,arCOG06187@2157|Archaea,2XTSP@28890|Euryarchaeota,23S9E@183963|Halobacteria	183963|Halobacteria	D	COG1077 Actin-like ATPase involved in cell morphogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4589521_1	237368.SCABRO_01907	3.847e-39	151.0	COG0629@1|root,COG0629@2|Bacteria,2IZJ8@203682|Planctomycetes	203682|Planctomycetes	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
CMS3_k127_4589859_3	1254432.SCE1572_08190	7.521e-13	78.0	COG3495@1|root,COG3495@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3299)	-	-	-	ko:K09950	-	-	-	-	ko00000	-	-	-	DUF3299
CMS3_k127_4589859_1	344747.PM8797T_07599	1.19e-52	209.0	COG0577@1|root,COG0577@2|Bacteria,2IY8W@203682|Planctomycetes	203682|Planctomycetes	V	Permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_4589859_0	886293.Sinac_4850	3.247e-54	205.0	COG1136@1|root,COG1136@2|Bacteria,2IYXY@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_4589859_2	1335757.SPICUR_07735	1.451e-18	98.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1WX79@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
CMS3_k127_4591703_4	1347368.HG964405_gene5816	2.149e-09	70.0	COG1595@1|root,COG1595@2|Bacteria,1V9ZH@1239|Firmicutes,4HGNB@91061|Bacilli,1ZGEX@1386|Bacillus	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_4591703_1	521674.Plim_1206	3.289e-33	145.0	COG1196@1|root,COG1196@2|Bacteria,2IYM0@203682|Planctomycetes	203682|Planctomycetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4591703_2	521674.Plim_1206	1.039e-17	87.0	COG1196@1|root,COG1196@2|Bacteria,2IYM0@203682|Planctomycetes	203682|Planctomycetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4591703_0	497964.CfE428DRAFT_5151	5.156e-93	316.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_11,SBP_bac_6,SBP_bac_8
CMS3_k127_4591703_3	344747.PM8797T_28934	5.69e-16	92.0	2CBS1@1|root,32RTY@2|Bacteria,2J3DR@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4591809_1	595460.RRSWK_00675	5.754e-17	96.0	28N64@1|root,2ZBFG@2|Bacteria,2IYGV@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase of plants and bacteria	-	-	-	-	-	-	-	-	-	-	-	-	BSP
CMS3_k127_4591809_0	861299.J421_1240	1.176e-84	301.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZUHA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
CMS3_k127_459248_0	926562.Oweho_2017	1.943e-52	205.0	COG1033@1|root,COG1033@2|Bacteria,4NE0M@976|Bacteroidetes,1HYND@117743|Flavobacteriia,2PA5Y@246874|Cryomorphaceae	976|Bacteroidetes	S	Sterol-sensing domain of SREBP cleavage-activation	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS3_k127_4610574_2	1232410.KI421418_gene2109	2.132e-17	93.0	COG0457@1|root,COG0457@2|Bacteria,1QXNU@1224|Proteobacteria,43C4R@68525|delta/epsilon subdivisions,2X7F5@28221|Deltaproteobacteria,43SFM@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Peptidase MA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2,TPR_16,TPR_2,TPR_8
CMS3_k127_4610574_1	1430331.EP10_09380	7.625e-42	173.0	COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,4HB1W@91061|Bacilli,1WFJ7@129337|Geobacillus	91061|Bacilli	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
CMS3_k127_4610574_0	404589.Anae109_0502	2.162e-250	796.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2YXS2@29|Myxococcales	28221|Deltaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
CMS3_k127_462467_2	1122179.KB890458_gene820	0.0007624	50.0	COG0652@1|root,COG1413@1|root,COG0652@2|Bacteria,COG1413@2|Bacteria,4PIRV@976|Bacteroidetes,1IZ2E@117747|Sphingobacteriia	976|Bacteroidetes	CO	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,Pro_isomerase
CMS3_k127_462467_0	518766.Rmar_1907	6.103e-76	276.0	COG2866@1|root,COG2866@2|Bacteria,4NF5T@976|Bacteroidetes	976|Bacteroidetes	E	Carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS3_k127_462467_1	378806.STAUR_4473	2.892e-28	127.0	COG4932@1|root,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,43CJR@68525|delta/epsilon subdivisions,2X7U3@28221|Deltaproteobacteria,2Z3HT@29|Myxococcales	28221|Deltaproteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4643124_3	526227.Mesil_0657	4.676e-61	230.0	COG3055@1|root,COG3055@2|Bacteria,1WK3E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1
CMS3_k127_4643124_6	349521.HCH_01090	2.453e-39	156.0	COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,1RRV4@1236|Gammaproteobacteria,1XIB8@135619|Oceanospirillales	135619|Oceanospirillales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
CMS3_k127_4643124_7	1434929.X946_2877	4.019e-28	117.0	COG0607@1|root,COG0607@2|Bacteria,1MZPW@1224|Proteobacteria,2VU52@28216|Betaproteobacteria,1K7NH@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM Rhodanese domain protein	pspE2	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CMS3_k127_4643124_5	314230.DSM3645_11177	2.984e-45	170.0	COG0241@1|root,COG0241@2|Bacteria,2IZYR@203682|Planctomycetes	203682|Planctomycetes	E	Polynucleotide kinase 3 phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_like
CMS3_k127_4643124_0	713587.THITH_05710	2.38e-115	390.0	COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,1RPNC@1236|Gammaproteobacteria,1WWNY@135613|Chromatiales	135613|Chromatiales	G	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
CMS3_k127_4643124_1	886293.Sinac_1073	3.547e-79	272.0	COG0647@1|root,COG0647@2|Bacteria	2|Bacteria	G	UMP catabolic process	-	-	3.1.3.41	ko:K01101,ko:K02566	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
CMS3_k127_4643124_2	1210884.HG799471_gene14563	1.193e-63	248.0	COG0515@1|root,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_4643124_4	671143.DAMO_1717	3.107e-55	221.0	COG0840@1|root,COG0840@2|Bacteria,2NQS9@2323|unclassified Bacteria	2|Bacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,PAS_3,TarH,dCache_1
CMS3_k127_4643124_8	1340493.JNIF01000004_gene181	0.0005863	49.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	ptpA_1	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
CMS3_k127_4645617_2	344747.PM8797T_05380	4.884e-36	143.0	COG0673@1|root,COG0673@2|Bacteria,2IXE4@203682|Planctomycetes	2|Bacteria	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_4645617_1	880526.KE386488_gene1576	5.08e-67	255.0	COG0823@1|root,COG0823@2|Bacteria,4NIGD@976|Bacteroidetes,2G2P7@200643|Bacteroidia	976|Bacteroidetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4645617_0	1291050.JAGE01000001_gene868	4.506e-116	394.0	COG1858@1|root,COG2730@1|root,COG3391@1|root,COG1858@2|Bacteria,COG2730@2|Bacteria,COG3391@2|Bacteria,1TSS4@1239|Firmicutes,24F1E@186801|Clostridia,3WHGQ@541000|Ruminococcaceae	186801|Clostridia	GP	Ricin-type beta-trefoil	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Dockerin_1,RicinB_lectin_2
CMS3_k127_4648436_1	1254432.SCE1572_29710	2.792e-115	396.0	COG0241@1|root,COG0645@1|root,COG0667@1|root,COG0241@2|Bacteria,COG0645@2|Bacteria,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	gmhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914	1.1.1.65,3.1.3.82,3.1.3.83,6.3.4.4	ko:K01939,ko:K03273,ko:K05275	ko00230,ko00250,ko00540,ko00750,ko01100,ko01120,map00230,map00250,map00540,map00750,map01100,map01120	M00049,M00064	R01135,R01708,R05647,R09771	RC00017,RC00116,RC00458,RC00459	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	AAA_33,Aldo_ket_red,Hydrolase_like
CMS3_k127_4648436_2	502025.Hoch_5093	4.098e-86	292.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2WIN0@28221|Deltaproteobacteria,2Z10D@29|Myxococcales	28221|Deltaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
CMS3_k127_4648436_0	1192034.CAP_2782	2.122e-207	660.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MCF@68525|delta/epsilon subdivisions,2WJRK@28221|Deltaproteobacteria,2YYUX@29|Myxococcales	28221|Deltaproteobacteria	I	AMP-binding enzyme C-terminal domain	bamY	-	6.2.1.25	ko:K04110	ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120	-	R01422	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2143	AMP-binding,AMP-binding_C
CMS3_k127_4648436_3	1229204.AMYY01000013_gene204	2.922e-23	100.0	COG0520@1|root,COG0520@2|Bacteria,1PP8J@1224|Proteobacteria,2V1RP@28211|Alphaproteobacteria,4BRJI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_4659045_1	290397.Adeh_0773	1.893e-25	115.0	COG0682@1|root,COG0682@2|Bacteria,1Q2R4@1224|Proteobacteria,438CQ@68525|delta/epsilon subdivisions,2WP0G@28221|Deltaproteobacteria,2YWK4@29|Myxococcales	28221|Deltaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CMS3_k127_4659045_0	632292.Calhy_0897	4.166e-36	144.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia,42F4T@68295|Thermoanaerobacterales	186801|Clostridia	NU	PFAM Type II secretion system protein E	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS3_k127_4660611_2	926569.ANT_08100	5.774e-63	220.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
CMS3_k127_4660611_6	526227.Mesil_1121	2.893e-10	66.0	COG2319@1|root,COG2319@2|Bacteria,1WK2V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	WD40
CMS3_k127_4660611_4	1112212.JH584235_gene2729	6.167e-27	110.0	COG1278@1|root,COG1278@2|Bacteria,1QRMX@1224|Proteobacteria,2V17U@28211|Alphaproteobacteria,2KB7U@204457|Sphingomonadales	204457|Sphingomonadales	K	Cold shock protein domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD
CMS3_k127_4660611_0	1380394.JADL01000026_gene4735	1.622e-142	475.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,2JQDT@204441|Rhodospirillales	204441|Rhodospirillales	JKL	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
CMS3_k127_4660611_1	1123256.KB907947_gene2652	5.765e-127	421.0	COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,1S0IS@1236|Gammaproteobacteria,1X4IQ@135614|Xanthomonadales	135614|Xanthomonadales	I	Fatty acid desaturase	-	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
CMS3_k127_4660611_5	671143.DAMO_2125	2.371e-21	99.0	COG0724@1|root,COG0724@2|Bacteria,2NPT0@2323|unclassified Bacteria	2|Bacteria	S	RNA recognition motif	rbpD	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS3_k127_4660611_3	886293.Sinac_7479	9.379e-63	248.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
CMS3_k127_4664316_0	314230.DSM3645_13253	1.727e-147	480.0	COG1793@1|root,COG3831@1|root,COG1793@2|Bacteria,COG3831@2|Bacteria,2IYN5@203682|Planctomycetes	203682|Planctomycetes	L	DNA ligase OB-like domain	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_OB_2,WGR
CMS3_k127_4664316_1	1248760.ANFZ01000018_gene636	2.321e-95	322.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria,2K06J@204457|Sphingomonadales	204457|Sphingomonadales	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_4664316_2	1303518.CCALI_01581	2.859e-11	76.0	2A08G@1|root,33ENC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4670055_0	483219.LILAB_21145	2.424e-119	404.0	COG0312@1|root,COG0312@2|Bacteria,1Q3C0@1224|Proteobacteria,4393A@68525|delta/epsilon subdivisions,2X495@28221|Deltaproteobacteria,2YYIX@29|Myxococcales	28221|Deltaproteobacteria	S	peptidase U62 modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
CMS3_k127_4670055_1	1002367.HMPREF0673_01683	0.0005366	53.0	COG4099@1|root,COG4099@2|Bacteria,4NFSH@976|Bacteroidetes,2FNUZ@200643|Bacteroidia	976|Bacteroidetes	S	Phospholipase carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,DLH,Esterase,Peptidase_S9
CMS3_k127_4674909_1	1183438.GKIL_4225	1.224e-18	98.0	COG3555@1|root,COG3555@2|Bacteria,1G0W9@1117|Cyanobacteria	1117|Cyanobacteria	O	Aspartyl asparaginyl beta-hydroxylase	-	-	-	ko:K12979	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Asp_Arg_Hydrox
CMS3_k127_4674909_0	1111069.TCCBUS3UF1_22290	1.36e-62	239.0	COG1572@1|root,COG3291@1|root,COG4447@1|root,COG1572@2|Bacteria,COG3291@2|Bacteria,COG4447@2|Bacteria,1WJJH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Peptidase M66	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_M66
CMS3_k127_467730_0	99598.Cal7507_2658	1.265e-134	442.0	COG1819@1|root,COG1819@2|Bacteria,1G1XQ@1117|Cyanobacteria,1HK8E@1161|Nostocales	1117|Cyanobacteria	CG	Glycosyltransferase family 28 N-terminal domain	crtX	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_28,UDPGT
CMS3_k127_467730_1	1129794.C427_1223	1.038e-83	297.0	COG2706@1|root,COG3391@1|root,COG3637@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,COG3637@2|Bacteria,1QWRQ@1224|Proteobacteria,1T4S3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_467730_2	1211815.CBYP010000044_gene392	2.736e-48	194.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	dprE1	GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010383,GO:0016020,GO:0016051,GO:0031221,GO:0033692,GO:0034637,GO:0034645,GO:0035884,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0070589,GO:0070592,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901576	1.1.98.3	ko:K16653	-	-	-	-	ko00000,ko01000	-	-	-	ALO,FAD_binding_4
CMS3_k127_467730_3	34740.HMEL022584-PA	5.732e-17	86.0	COG0666@1|root,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3BGGV@33208|Metazoa,3CT1S@33213|Bilateria,41TUY@6656|Arthropoda,3SH8U@50557|Insecta,447XY@7088|Lepidoptera	33208|Metazoa	M	Ankyrin repeat	Ank	GO:0000902,GO:0000904,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006928,GO:0006935,GO:0006996,GO:0007010,GO:0007016,GO:0007275,GO:0007399,GO:0007409,GO:0007411,GO:0008092,GO:0008104,GO:0008150,GO:0009605,GO:0009653,GO:0009987,GO:0010171,GO:0016020,GO:0016043,GO:0016328,GO:0022008,GO:0030030,GO:0030154,GO:0030182,GO:0030507,GO:0031175,GO:0032501,GO:0032502,GO:0032507,GO:0032989,GO:0032990,GO:0033036,GO:0033563,GO:0034613,GO:0040008,GO:0040011,GO:0040014,GO:0040018,GO:0042221,GO:0042330,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045170,GO:0045185,GO:0045927,GO:0048468,GO:0048518,GO:0048638,GO:0048639,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050789,GO:0050793,GO:0050839,GO:0050896,GO:0051094,GO:0051179,GO:0051235,GO:0051239,GO:0051240,GO:0051641,GO:0051651,GO:0061564,GO:0065007,GO:0065008,GO:0070727,GO:0071840,GO:0071944,GO:0097485,GO:0120036,GO:0120039	-	ko:K10380	ko04624,ko05205,map04624,map05205	-	-	-	ko00000,ko00001,ko04812	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,Apolipoprotein,Death,ZU5
CMS3_k127_4683070_4	471855.Shel_17360	9.945e-06	52.0	COG2304@1|root,COG2304@2|Bacteria,2GKDC@201174|Actinobacteria,4CVGF@84998|Coriobacteriia	84998|Coriobacteriia	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
CMS3_k127_4683070_2	1434929.X946_5700	1.715e-28	134.0	COG2911@1|root,COG3055@1|root,COG2911@2|Bacteria,COG3055@2|Bacteria,1MYQG@1224|Proteobacteria,2VX2F@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Kelch_1,Kelch_4,fn3
CMS3_k127_4683070_3	1121931.AUHG01000017_gene1556	7.946e-14	86.0	COG2706@1|root,COG2706@2|Bacteria,4NE87@976|Bacteroidetes,1I0Q4@117743|Flavobacteriia	976|Bacteroidetes	G	COG2706 3-carboxymuconate cyclase	-	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
CMS3_k127_4683070_1	1500897.JQNA01000002_gene83	1.047e-36	161.0	COG2706@1|root,COG2706@2|Bacteria,1RB38@1224|Proteobacteria,2VSAM@28216|Betaproteobacteria,1K6NQ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
CMS3_k127_4683070_0	1044.EH31_16945	1.161e-104	353.0	COG2345@1|root,COG2345@2|Bacteria,1PMAY@1224|Proteobacteria,2UIVM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4684388_1	215803.DB30_6480	1.115e-75	287.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,42P8D@68525|delta/epsilon subdivisions,2WMH1@28221|Deltaproteobacteria,2YWWP@29|Myxococcales	28221|Deltaproteobacteria	KLT	COG0515 Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase,Pkinase_Tyr,WD40
CMS3_k127_4684388_3	1068980.ARVW01000001_gene6236	5.004e-07	62.0	COG5563@1|root,COG5563@2|Bacteria,2GTNJ@201174|Actinobacteria,4EDEJ@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4684388_2	756272.Plabr_0708	3.122e-40	156.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS3_k127_4684388_0	1210884.HG799463_gene9871	1.405e-130	442.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,WD40
CMS3_k127_4698615_0	886293.Sinac_3442	2.165e-17	97.0	COG0526@1|root,COG1470@1|root,COG1595@1|root,COG0526@2|Bacteria,COG1470@2|Bacteria,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	AhpC-TSA,DUF4384,NPCBM_assoc,PEGA,Sigma70_r2,Sigma70_r4_2,Thioredoxin_8
CMS3_k127_4698615_1	1089551.KE386572_gene1386	7.465e-07	57.0	28ID9@1|root,2Z8FI@2|Bacteria,1PD20@1224|Proteobacteria,2U8T2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter
CMS3_k127_4705374_1	34007.IT40_24760	3.69e-45	177.0	COG2044@1|root,COG2044@2|Bacteria,1RIFN@1224|Proteobacteria,2UBMI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
CMS3_k127_4705374_2	1123507.ATVQ01000003_gene618	2.72e-13	78.0	2BMJ7@1|root,32G45@2|Bacteria,2H1DR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
CMS3_k127_4705374_3	500153.JOEK01000001_gene4029	2.049e-08	61.0	2E641@1|root,330T1@2|Bacteria,2IRTU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4705374_0	1123242.JH636435_gene2223	1.196e-87	325.0	COG1520@1|root,COG3391@1|root,COG1520@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114
CMS3_k127_4713399_6	1123322.KB904735_gene1462	5.908e-26	123.0	COG1126@1|root,COG1126@2|Bacteria	2|Bacteria	E	abc transporter atp-binding protein	glnQ	-	3.6.3.21	ko:K02028,ko:K02029	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran,BPD_transp_1
CMS3_k127_4713399_7	477228.YO5_13718	4.949e-21	107.0	COG3008@1|root,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,1RN89@1236|Gammaproteobacteria,1YZUI@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	Q	COG3008 Paraquat-inducible protein B	yebT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0016020,GO:0016021,GO:0016043,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071840,GO:0071944,GO:0120009	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
CMS3_k127_4713399_5	1123393.KB891327_gene304	2.788e-43	164.0	COG3663@1|root,COG3663@2|Bacteria,1REPV@1224|Proteobacteria,2VRAT@28216|Betaproteobacteria,1KSZ9@119069|Hydrogenophilales	119069|Hydrogenophilales	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
CMS3_k127_4713399_0	861299.J421_1532	7.85e-265	831.0	COG0021@1|root,COG0021@2|Bacteria,1ZTA2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
CMS3_k127_4713399_4	1201290.M902_1885	4.46e-65	244.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
CMS3_k127_4713399_3	1353529.M899_3107	1.177e-81	281.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,43AFB@68525|delta/epsilon subdivisions,2X5J0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
CMS3_k127_4713399_2	862908.BMS_3003	3.457e-138	463.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,42Z5J@68525|delta/epsilon subdivisions,2X7Z6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
CMS3_k127_4713399_1	237368.SCABRO_03039	1.981e-158	511.0	COG0188@1|root,COG0188@2|Bacteria,2IY0U@203682|Planctomycetes	203682|Planctomycetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CMS3_k127_4713721_3	1121448.DGI_1551	0.0002934	54.0	COG0247@1|root,COG0398@1|root,COG0247@2|Bacteria,COG0398@2|Bacteria,1NKKI@1224|Proteobacteria,42NPC@68525|delta/epsilon subdivisions,2WJ4N@28221|Deltaproteobacteria,2MH9U@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8,SNARE_assoc
CMS3_k127_4713721_2	118168.MC7420_4190	2.978e-30	140.0	COG0277@1|root,COG0277@2|Bacteria,1G6C2@1117|Cyanobacteria,1HDSK@1150|Oscillatoriales	1117|Cyanobacteria	C	FAD binding domain	-	-	1.5.99.12	ko:K00279	ko00908,map00908	-	R05708	RC00121,RC01455	ko00000,ko00001,ko01000	-	-	-	BBE,Cytokin-bind,FAD_binding_4
CMS3_k127_4713721_1	1210884.HG799466_gene12567	4.677e-122	425.0	COG0526@1|root,COG0526@2|Bacteria,2IWVQ@203682|Planctomycetes	203682|Planctomycetes	CO	PFAM Copper type II ascorbate-dependent monooxygenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Cu2_monoox_C
CMS3_k127_4713721_0	1519464.HY22_09345	2.328e-127	423.0	COG1236@1|root,COG1236@2|Bacteria,1FER3@1090|Chlorobi	1090|Chlorobi	J	PFAM beta-lactamase domain protein	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
CMS3_k127_4718275_2	292459.STH516	1.264e-27	129.0	COG1149@1|root,COG1149@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	napF	-	-	ko:K02572,ko:K02573	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7,Fer4_9
CMS3_k127_4718275_0	344747.PM8797T_26205	4.571e-222	706.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	DUF1863,PQQ,PQQ_2,PQQ_3
CMS3_k127_4719971_4	335543.Sfum_3572	1.653e-15	87.0	COG5316@1|root,COG5316@2|Bacteria,1NWFX@1224|Proteobacteria,42NSK@68525|delta/epsilon subdivisions,2WMAZ@28221|Deltaproteobacteria,2MR3J@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
CMS3_k127_4719971_2	713587.THITH_03915	1.166e-42	169.0	COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,1RNGA@1236|Gammaproteobacteria,1WX4Y@135613|Chromatiales	135613|Chromatiales	G	Protein of unknown function (DUF455)	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF455
CMS3_k127_4719971_3	1123508.JH636448_gene7570	2.349e-27	117.0	COG3682@1|root,COG3682@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS3_k127_4719971_1	1123508.JH636443_gene4728	1.73e-55	218.0	COG4219@1|root,COG4219@2|Bacteria,2J24Z@203682|Planctomycetes	203682|Planctomycetes	KT	Antirepressor regulating drug resistance	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
CMS3_k127_4719971_0	1519464.HY22_03915	8.92e-233	743.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	yuxL	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
CMS3_k127_4722904_2	29850.GGTG_07456T0	0.0002242	50.0	2EHH0@1|root,2SN5B@2759|Eukaryota,3AIPJ@33154|Opisthokonta,3PBUI@4751|Fungi,3QV7G@4890|Ascomycota,21A6C@147550|Sordariomycetes,41R6P@639021|Magnaporthales	4751|Fungi	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS3_k127_4722904_1	1174528.JH992889_gene72	9.543e-14	83.0	COG0398@1|root,COG0398@2|Bacteria,1G6GT@1117|Cyanobacteria,1JKIC@1189|Stigonemataceae	1117|Cyanobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS3_k127_4722904_0	1163398.AJJP01000115_gene869	4.533e-113	385.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the pirin family	yhhW_1	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
CMS3_k127_4725347_3	1210884.HG799465_gene11812	8.244e-09	66.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	PD40,Sigma70_r2,Sigma70_r4_2
CMS3_k127_4725347_1	530564.Psta_1360	1.057e-43	175.0	COG1657@1|root,COG1657@2|Bacteria,2IX8J@203682|Planctomycetes	203682|Planctomycetes	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4725347_2	195250.CM001776_gene2398	8.381e-28	113.0	COG1942@1|root,COG1942@2|Bacteria,1G9PD@1117|Cyanobacteria	1117|Cyanobacteria	G	4-oxalocrotonate tautomerase family	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
CMS3_k127_4725347_0	1304878.AUGD01000017_gene999	4.332e-175	565.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JV88@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_4725347_4	349521.HCH_02985	1.604e-06	54.0	COG2273@1|root,COG3568@1|root,COG2273@2|Bacteria,COG3568@2|Bacteria,1QZA0@1224|Proteobacteria,1T42V@1236|Gammaproteobacteria,1XQJT@135619|Oceanospirillales	2|Bacteria	G	Cellulose Binding Domain Type IV	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CBM_4_9,CBM_6,DHOR,Exo_endo_phos,F5_F8_type_C,FIVAR,Glyco_hydro_16,TSP_3
CMS3_k127_4737738_2	1279017.AQYJ01000028_gene2131	3.021e-10	74.0	COG2936@1|root,COG2936@2|Bacteria,1QU2I@1224|Proteobacteria,1S1VW@1236|Gammaproteobacteria,469YI@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
CMS3_k127_4737738_1	595460.RRSWK_02101	3.062e-56	224.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,WD40
CMS3_k127_4737738_5	1117108.PAALTS15_25284	2.662e-06	57.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HI9N@91061|Bacilli,26XD3@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_4737738_0	937777.Deipe_2732	6.708e-79	276.0	COG3483@1|root,COG3483@2|Bacteria	2|Bacteria	E	tryptophan 2,3-dioxygenase activity	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11,4.1.1.45	ko:K00453,ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R00678,R04323	RC00356,RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
CMS3_k127_4737738_4	316274.Haur_2561	4.094e-07	57.0	COG0721@1|root,COG0721@2|Bacteria,2G763@200795|Chloroflexi,375YU@32061|Chloroflexia	32061|Chloroflexia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
CMS3_k127_4737738_3	405948.SACE_4294	1.095e-08	61.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4E0AI@85010|Pseudonocardiales	201174|Actinobacteria	J	Amidase	bam	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
CMS3_k127_4753973_1	1123242.JH636438_gene5844	5.915e-41	172.0	COG1657@1|root,COG1657@2|Bacteria,2IXQ8@203682|Planctomycetes	203682|Planctomycetes	I	Prenyltransferase and squalene oxidase repeat	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
CMS3_k127_4753973_0	1125863.JAFN01000001_gene1414	5.176e-77	274.0	COG1606@1|root,COG1606@2|Bacteria,1R7UZ@1224|Proteobacteria,42Q6V@68525|delta/epsilon subdivisions,2WKIM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM asparagine synthase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase,QueC
CMS3_k127_4753973_2	1246626.BleG1_2740	6.637e-06	57.0	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,4H9T6@91061|Bacilli,1ZBDY@1386|Bacillus	91061|Bacilli	S	amidohydrolase	nfdA_1	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS3_k127_4766695_2	234267.Acid_0898	6.185e-21	97.0	COG3682@1|root,COG3682@2|Bacteria,3Y5AK@57723|Acidobacteria	57723|Acidobacteria	K	PFAM Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS3_k127_4766695_1	1370125.AUWT01000057_gene1128	1.248e-36	147.0	COG0640@1|root,COG0640@2|Bacteria,2GJT9@201174|Actinobacteria,2369B@1762|Mycobacteriaceae	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
CMS3_k127_4766695_3	103733.JNYO01000009_gene4614	1.724e-15	87.0	COG3832@1|root,COG3832@2|Bacteria,2HQ66@201174|Actinobacteria,4E35N@85010|Pseudonocardiales	201174|Actinobacteria	S	Pfam Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,Polyketide_cyc2
CMS3_k127_4766695_0	314230.DSM3645_24145	5.585e-230	719.0	COG3119@1|root,COG3119@2|Bacteria,2IXIU@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.8	ko:K01134	ko00600,ko04142,map00600,map04142	-	R04856	RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
CMS3_k127_4768728_0	243233.MCA2174	9.449e-81	279.0	COG0803@1|root,COG0803@2|Bacteria,1RAQU@1224|Proteobacteria	1224|Proteobacteria	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
CMS3_k127_4768728_1	583355.Caka_2183	1.787e-54	199.0	COG0577@1|root,COG0577@2|Bacteria,46TM1@74201|Verrucomicrobia	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	MacB_PCD
CMS3_k127_4782672_2	405948.SACE_4049	1.27e-05	51.0	COG2355@1|root,COG2355@2|Bacteria,2GN82@201174|Actinobacteria,4DX4Y@85010|Pseudonocardiales	201174|Actinobacteria	E	Membrane dipeptidase (Peptidase family M19)	Dpep	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
CMS3_k127_4782672_0	243090.RB1939	9.782e-174	559.0	COG0673@1|root,COG0673@2|Bacteria,2IXFW@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_4782672_1	247490.KSU1_D0646	3.489e-92	325.0	COG3507@1|root,COG5306@1|root,COG3507@2|Bacteria,COG5306@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	exbB2	-	3.4.14.5	ko:K01278,ko:K03561,ko:K12287	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko02044,ko04090,ko04147	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
CMS3_k127_4783461_1	1047013.AQSP01000142_gene185	3.474e-62	218.0	COG4447@1|root,COG4447@2|Bacteria,2NQ6W@2323|unclassified Bacteria	2|Bacteria	S	Por secretion system C-terminal sorting domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
CMS3_k127_4783461_0	1210884.HG799463_gene9849	2.659e-218	709.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2IYT8@203682|Planctomycetes	2|Bacteria	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS3_k127_4783461_2	795797.C497_11857	0.0001773	53.0	COG1413@1|root,arCOG04653@2157|Archaea,2XUXY@28890|Euryarchaeota,23SVC@183963|Halobacteria	183963|Halobacteria	C	COG1413 FOG HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS3_k127_4798330_1	697281.Mahau_2088	4.252e-11	76.0	COG3664@1|root,COG5434@1|root,COG5492@1|root,COG3664@2|Bacteria,COG5434@2|Bacteria,COG5492@2|Bacteria,1UIHA@1239|Firmicutes,25GPW@186801|Clostridia,42IXE@68295|Thermoanaerobacterales	1239|Firmicutes	N	Ig domain protein group 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,CBM_6
CMS3_k127_4798330_2	237368.SCABRO_00735	1.633e-09	70.0	COG0681@1|root,COG0681@2|Bacteria,2IYWI@203682|Planctomycetes	203682|Planctomycetes	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
CMS3_k127_4798330_0	698758.AXY_05430	1.411e-11	69.0	COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,4HASP@91061|Bacilli	91061|Bacilli	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
CMS3_k127_4798555_0	414684.RC1_3493	1.152e-204	656.0	COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2TTAX@28211|Alphaproteobacteria,2JYHC@204441|Rhodospirillales	204441|Rhodospirillales	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
CMS3_k127_4798555_1	472759.Nhal_0822	5.741e-107	358.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJ6@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS3_k127_4800703_0	243090.RB5146	2.093e-223	703.0	COG3119@1|root,COG3119@2|Bacteria,2IY4T@203682|Planctomycetes	203682|Planctomycetes	P	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
CMS3_k127_4806414_1	460265.Mnod_7207	2.43e-08	59.0	COG4485@1|root,COG4485@2|Bacteria,1NBM0@1224|Proteobacteria,2U1FH@28211|Alphaproteobacteria,1JRUY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Bacterial membrane protein, YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
CMS3_k127_4806414_2	765420.OSCT_0910	1.618e-07	57.0	COG0457@1|root,COG1716@1|root,COG4447@1|root,COG0457@2|Bacteria,COG1716@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CarboxypepD_reg,FHA,Kelch_4,NHL,PA14,Peptidase_C11
CMS3_k127_4806414_0	1121918.ARWE01000001_gene3079	7.568e-90	305.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42P5P@68525|delta/epsilon subdivisions,2WITN@28221|Deltaproteobacteria,43TQJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	HI0933-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_9,Pyr_redox_2
CMS3_k127_4813306_0	313628.LNTAR_07229	7.117e-146	474.0	COG3119@1|root,COG3119@2|Bacteria	313628.LNTAR_07229|-	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4813306_2	1415756.JQMY01000001_gene2812	2.258e-08	68.0	COG4249@1|root,COG4249@2|Bacteria,1PESZ@1224|Proteobacteria,2V7EG@28211|Alphaproteobacteria,2PC93@252301|Oceanicola	28211|Alphaproteobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
CMS3_k127_4813306_1	1380600.AUYN01000001_gene2864	1.189e-119	414.0	COG1520@1|root,COG1520@2|Bacteria,4NHPR@976|Bacteroidetes,1HXXS@117743|Flavobacteriia	976|Bacteroidetes	G	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans
CMS3_k127_4824780_0	1210884.HG799463_gene9871	5.566e-97	351.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,WD40
CMS3_k127_4830426_0	1121434.AULY01000006_gene782	3.554e-158	508.0	COG2855@1|root,COG2855@2|Bacteria,1MVPE@1224|Proteobacteria,42NT6@68525|delta/epsilon subdivisions,2WJ9R@28221|Deltaproteobacteria,2M8W4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	family UPF0324	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
CMS3_k127_4830426_1	56110.Oscil6304_1832	1.34e-26	121.0	COG1063@1|root,COG1063@2|Bacteria,1FZZE@1117|Cyanobacteria,1H7Y9@1150|Oscillatoriales	1117|Cyanobacteria	E	COG1063 Threonine dehydrogenase and related Zn-dependent	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N,Shikimate_DH
CMS3_k127_4832052_1	861299.J421_3288	3.35e-97	329.0	COG1005@1|root,COG1005@2|Bacteria,1ZTDY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
CMS3_k127_4832052_2	945713.IALB_0895	1.219e-47	185.0	COG1143@1|root,COG1143@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00338,ko:K02573	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
CMS3_k127_4832052_3	1125863.JAFN01000001_gene2412	2.682e-20	101.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,42RES@68525|delta/epsilon subdivisions,2WSB9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
CMS3_k127_4832052_4	1340493.JNIF01000003_gene1642	2.482e-17	91.0	COG0713@1|root,COG0713@2|Bacteria,3Y4XI@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
CMS3_k127_4832052_0	379066.GAU_2392	1.953e-167	550.0	COG1009@1|root,COG1009@2|Bacteria,1ZUA7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
CMS3_k127_4832052_6	1380394.JADL01000005_gene5393	6.902e-07	57.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2TSNK@28211|Alphaproteobacteria,2JPNK@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M)	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
CMS3_k127_4832052_5	1124780.ANNU01000010_gene3649	7.73e-10	72.0	COG0654@1|root,COG0654@2|Bacteria,4NGIU@976|Bacteroidetes,47KM9@768503|Cytophagia	976|Bacteroidetes	H	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid	kmo	-	1.14.13.9	ko:K00486	ko00380,ko01100,map00380,map01100	M00038	R01960	RC00046	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
CMS3_k127_4833555_0	1123242.JH636435_gene2797	4.126e-129	430.0	COG2010@1|root,COG2010@2|Bacteria,2J547@203682|Planctomycetes	203682|Planctomycetes	C	PFAM Copper type II ascorbate-dependent monooxygenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4833555_3	595460.RRSWK_06192	0.0002687	53.0	COG0526@1|root,COG1225@1|root,COG0526@2|Bacteria,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	bcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.1.98.6,1.11.1.15,1.8.1.9,1.8.4.11,1.8.4.12	ko:K00384,ko:K03564,ko:K12057,ko:K12267,ko:K21636	ko00230,ko00240,ko00450,ko01100,map00230,map00240,map00450,map01100	M00053	R02016,R03596,R09372,R11633,R11634,R11635,R11636	RC00013,RC00613,RC02518,RC02873	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.7.11.1	-	-	AhpC-TSA
CMS3_k127_4833555_1	1123242.JH636435_gene2796	1.117e-20	98.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_4841138_2	1304874.JAFY01000007_gene2477	1.972e-31	126.0	COG0507@1|root,COG0507@2|Bacteria,3TA7X@508458|Synergistetes	508458|Synergistetes	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,Herpes_Helicase,PIF1,UvrD_C_2,WYL
CMS3_k127_4841138_5	1238182.C882_3795	1.877e-11	76.0	COG0760@1|root,COG0760@2|Bacteria,1PZP1@1224|Proteobacteria,2UDJZ@28211|Alphaproteobacteria,2JTBF@204441|Rhodospirillales	204441|Rhodospirillales	O	COG0760 Parvulin-like peptidyl-prolyl isomerase	-	-	5.2.1.8	ko:K03769,ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
CMS3_k127_4841138_4	518766.Rmar_0756	1.169e-13	83.0	COG0760@1|root,COG0760@2|Bacteria,4NDZZ@976|Bacteroidetes,1FIMM@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	SurA N-terminal domain	ppiD	-	5.2.1.8	ko:K01802,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,Rotamase_3,SurA_N_2
CMS3_k127_4841138_0	1123242.JH636434_gene3495	1.809e-88	331.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
CMS3_k127_4841138_3	309807.SRU_2040	6.17e-14	78.0	COG1310@1|root,COG1310@2|Bacteria,4NTI0@976|Bacteroidetes,1FJCV@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	JAB/MPN domain	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
CMS3_k127_4841138_1	748247.AZKH_4056	1.417e-54	200.0	COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2VMMI@28216|Betaproteobacteria,2KW7J@206389|Rhodocyclales	206389|Rhodocyclales	S	Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
CMS3_k127_4843251_1	502025.Hoch_6445	5.845e-93	330.0	COG3488@1|root,COG3488@2|Bacteria	2|Bacteria	C	Di-haem oxidoreductase, putative peroxidase	-	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	DHOR
CMS3_k127_4843251_0	344747.PM8797T_20044	3.709e-171	554.0	COG3119@1|root,COG3119@2|Bacteria,2IXG7@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
CMS3_k127_4843251_2	258533.BN977_04937	8.955e-06	54.0	COG4122@1|root,COG4122@2|Bacteria,2GNMM@201174|Actinobacteria,238WV@1762|Mycobacteriaceae	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
CMS3_k127_4844673_0	1192034.CAP_7351	1.825e-194	629.0	COG0665@1|root,COG4676@1|root,COG0665@2|Bacteria,COG4676@2|Bacteria,1QX8E@1224|Proteobacteria,43C1H@68525|delta/epsilon subdivisions,2X7C5@28221|Deltaproteobacteria,2YUS8@29|Myxococcales	28221|Deltaproteobacteria	E	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2135,VIT,VWA_3
CMS3_k127_4845758_0	886293.Sinac_5710	5.47e-236	752.0	COG2010@1|root,COG2010@2|Bacteria,2IXJK@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
CMS3_k127_4845758_1	886293.Sinac_5711	3.238e-184	604.0	COG3119@1|root,COG3119@2|Bacteria,2IXQ7@203682|Planctomycetes	203682|Planctomycetes	P	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_4845758_5	1385515.N791_06925	9.1e-46	188.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1SN6U@1236|Gammaproteobacteria,1X5QM@135614|Xanthomonadales	135614|Xanthomonadales	O	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CMS3_k127_4845758_2	452637.Oter_0062	3.096e-150	502.0	COG4993@1|root,COG4993@2|Bacteria,46T43@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM Pyrrolo-quinoline quinone	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ
CMS3_k127_4845758_4	452637.Oter_0062	1.092e-58	209.0	COG4993@1|root,COG4993@2|Bacteria,46T43@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM Pyrrolo-quinoline quinone	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ
CMS3_k127_4845758_3	497964.CfE428DRAFT_5037	9.919e-122	401.0	COG1454@1|root,COG1454@2|Bacteria,46TD9@74201|Verrucomicrobia	74201|Verrucomicrobia	C	PFAM iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
CMS3_k127_4846107_1	237368.SCABRO_02621	6.647e-33	134.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CMS3_k127_4846107_0	546271.Selsp_0766	6.541e-120	400.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,4H20Q@909932|Negativicutes	909932|Negativicutes	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
CMS3_k127_4846107_2	589865.DaAHT2_1154	3.632e-32	136.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,42SD9@68525|delta/epsilon subdivisions,2WPPN@28221|Deltaproteobacteria,2MJQC@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3200	CTP_transf_like
CMS3_k127_4867614_1	631362.Thi970DRAFT_02360	8.136e-108	357.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1WWTW@135613|Chromatiales	135613|Chromatiales	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
CMS3_k127_4867614_0	479434.Sthe_0727	1.731e-119	407.0	COG0488@1|root,COG0488@2|Bacteria,2G5VD@200795|Chloroflexi,27XQY@189775|Thermomicrobia	189775|Thermomicrobia	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
CMS3_k127_4867614_2	1399115.U719_15610	5.894e-99	359.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,4HAR3@91061|Bacilli,3WEHI@539002|Bacillales incertae sedis	91061|Bacilli	J	Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
CMS3_k127_4873359_3	768710.DesyoDRAFT_3091	0.0002368	47.0	COG2963@1|root,COG2963@2|Bacteria,1VK5J@1239|Firmicutes	1239|Firmicutes	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
CMS3_k127_4873359_1	1125863.JAFN01000001_gene1431	6.397e-21	98.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,42VQ6@68525|delta/epsilon subdivisions,2WRTU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
CMS3_k127_4873359_2	868595.Desca_0783	1.366e-12	71.0	COG1550@1|root,COG1550@2|Bacteria,1VEHY@1239|Firmicutes,24QJY@186801|Clostridia,263AU@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
CMS3_k127_4873359_0	237368.SCABRO_03706	5.002e-181	597.0	COG0532@1|root,COG0532@2|Bacteria,2IXYU@203682|Planctomycetes	203682|Planctomycetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
CMS3_k127_4879784_2	926690.KE386573_gene2359	3.612e-09	61.0	COG1826@1|root,arCOG02694@2157|Archaea,2XZZ6@28890|Euryarchaeota,23XEX@183963|Halobacteria	183963|Halobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
CMS3_k127_4879784_0	886293.Sinac_2664	9.411e-67	241.0	COG0142@1|root,COG0142@2|Bacteria,2IXUE@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
CMS3_k127_4879784_1	452637.Oter_2586	6.636e-14	84.0	2E533@1|root,32ZW9@2|Bacteria,46SZX@74201|Verrucomicrobia,3K856@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4882644_0	631362.Thi970DRAFT_04894	2.543e-61	223.0	295V5@1|root,2ZT65@2|Bacteria,1REG0@1224|Proteobacteria,1S9HA@1236|Gammaproteobacteria,1WYWE@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4882644_3	290397.Adeh_3735	5.411e-22	104.0	COG1595@1|root,COG1595@2|Bacteria,1PEZT@1224|Proteobacteria,42W2J@68525|delta/epsilon subdivisions,2WS5K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_4882644_1	762963.HMPREF9056_02201	4.411e-50	202.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4D3IX@85005|Actinomycetales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS3_k127_4882644_2	491205.JARQ01000006_gene2674	4.02e-37	151.0	COG2304@1|root,COG2304@2|Bacteria,4NIM2@976|Bacteroidetes	976|Bacteroidetes	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
CMS3_k127_4888629_0	1089548.KI783301_gene2317	4.149e-110	384.0	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,4H9NZ@91061|Bacilli,3WE0T@539002|Bacillales incertae sedis	91061|Bacilli	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
CMS3_k127_4888629_1	886293.Sinac_3833	1.504e-35	149.0	COG2897@1|root,COG2897@2|Bacteria,2J06E@203682|Planctomycetes	203682|Planctomycetes	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
CMS3_k127_4893475_2	1123508.JH636443_gene4921	1.598e-88	303.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,PDZ,PDZ_2,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
CMS3_k127_4893475_7	420324.KI912090_gene7131	3.641e-41	168.0	COG1670@1|root,COG1670@2|Bacteria,1MVG4@1224|Proteobacteria,2TUIK@28211|Alphaproteobacteria,1JYCR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	rimJ	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
CMS3_k127_4893475_9	1267535.KB906767_gene2973	6.309e-18	88.0	2EFWM@1|root,339NX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4893475_6	269797.Mbar_A0235	7.59e-43	170.0	COG1216@1|root,arCOG01383@2157|Archaea,2XW51@28890|Euryarchaeota,2N9HF@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase family group 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
CMS3_k127_4893475_1	1499967.BAYZ01000139_gene141	3.498e-120	408.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS3_k127_4893475_4	187272.Mlg_2338	2.438e-50	195.0	COG0438@1|root,COG0438@2|Bacteria,1R3TV@1224|Proteobacteria,1RQZC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
CMS3_k127_4893475_5	404589.Anae109_1425	1.872e-49	192.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42R6N@68525|delta/epsilon subdivisions,2WP3W@28221|Deltaproteobacteria,2Z144@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_4893475_3	1173027.Mic7113_5268	9.656e-56	211.0	COG0438@1|root,COG0438@2|Bacteria,1GHSP@1117|Cyanobacteria,1HFYN@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4
CMS3_k127_4893475_8	886293.Sinac_2295	1.858e-27	126.0	COG1216@1|root,COG1216@2|Bacteria,2J316@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_4893475_0	1210884.HG799463_gene10030	1.501e-224	720.0	COG2010@1|root,COG2010@2|Bacteria,2IY1J@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
CMS3_k127_4895783_0	1122931.AUAE01000028_gene155	3.004e-211	678.0	COG0823@1|root,COG0823@2|Bacteria,4NIGD@976|Bacteroidetes,2G2P7@200643|Bacteroidia	976|Bacteroidetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4896264_4	1121413.JMKT01000012_gene683	9.403e-46	172.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2M88M@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CMS3_k127_4896264_1	378806.STAUR_4734	2.989e-71	254.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria,2YZJ4@29|Myxococcales	28221|Deltaproteobacteria	H	Pterin binding enzyme	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CMS3_k127_4896264_3	545697.HMPREF0216_00744	2.751e-50	189.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,249K8@186801|Clostridia,36DSC@31979|Clostridiaceae	186801|Clostridia	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
CMS3_k127_4896264_0	886293.Sinac_7534	8.076e-80	284.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4896264_2	1207063.P24_12042	4.801e-51	201.0	COG3119@1|root,COG3119@2|Bacteria,1PWEJ@1224|Proteobacteria,2TYVA@28211|Alphaproteobacteria,2JSHG@204441|Rhodospirillales	204441|Rhodospirillales	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4896264_5	448385.sce7486	3.361e-17	83.0	COG3682@1|root,COG3682@2|Bacteria,1N3MZ@1224|Proteobacteria	1224|Proteobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS3_k127_4896543_1	945713.IALB_2925	1.269e-140	459.0	COG3004@1|root,COG3004@2|Bacteria	2|Bacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
CMS3_k127_4896543_0	382464.ABSI01000006_gene852	0.0	1249.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	preT	-	1.2.7.1	ko:K00171,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_6,PFOR_II,POR,POR_N,Pyr_redox_2,Pyr_redox_3,TPP_enzyme_C
CMS3_k127_4923583_2	1115632.JAFW01000001_gene1488	2.314e-21	105.0	COG0583@1|root,COG0583@2|Bacteria,2GK13@201174|Actinobacteria,1W80A@1268|Micrococcaceae	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
CMS3_k127_4923583_0	136993.KB900627_gene447	2.871e-72	258.0	COG2706@1|root,COG2706@2|Bacteria,1NG69@1224|Proteobacteria	1224|Proteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
CMS3_k127_4939621_0	756272.Plabr_0079	1.018e-243	764.0	COG3119@1|root,COG3119@2|Bacteria,2IWVY@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS3_k127_4939621_1	595460.RRSWK_07152	5.134e-164	535.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM,NPCBM_assoc,Sulfatase
CMS3_k127_4940270_4	1128421.JAGA01000002_gene410	3.873e-09	68.0	COG0394@1|root,COG0394@2|Bacteria,2NPGV@2323|unclassified Bacteria	2|Bacteria	T	Low molecular weight phosphatase family	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
CMS3_k127_4940270_3	309801.trd_A0482	6.984e-56	209.0	COG1482@1|root,COG1482@2|Bacteria,2G6I2@200795|Chloroflexi,27XNI@189775|Thermomicrobia	189775|Thermomicrobia	G	Phosphomannose isomerase type I	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
CMS3_k127_4940270_2	1121430.JMLG01000010_gene179	1.045e-59	219.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,261JB@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS3_k127_4940270_0	1499967.BAYZ01000170_gene5483	2.574e-96	335.0	COG0612@1|root,COG0612@2|Bacteria,2NP5H@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_4940270_1	1499967.BAYZ01000170_gene5483	1.439e-92	321.0	COG0612@1|root,COG0612@2|Bacteria,2NP5H@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_4941313_0	1089550.ATTH01000001_gene758	1.255e-12	74.0	COG1680@1|root,COG1680@2|Bacteria,4PI6F@976|Bacteroidetes,1FJQ7@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_4941313_1	1120970.AUBZ01000004_gene220	0.0001144	53.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,465HB@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
CMS3_k127_4941313_2	568768.CM001975_gene2975	0.0007307	51.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,2JD5G@204037|Dickeya	1236|Gammaproteobacteria	NU	PFAM type II secretion system protein E	hofB	-	-	ko:K02454,ko:K02504,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
CMS3_k127_4943475_1	1123242.JH636434_gene5195	1.701e-13	75.0	COG3682@1|root,COG3682@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS3_k127_4943475_3	1027273.GZ77_19450	8.576e-05	51.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XH82@135619|Oceanospirillales	135619|Oceanospirillales	T	Histidine kinase	-	-	-	ko:K20972	ko02025,map02025	-	-	-	ko00000,ko00001,ko01001,ko02022	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,CHASE8,HATPase_c,HisKA,Hpt,PAS_4,Response_reg
CMS3_k127_4943475_0	1123242.JH636438_gene5826	7.812e-35	149.0	COG0642@1|root,COG2205@2|Bacteria,2IX1S@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Ammonium_transp,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg
CMS3_k127_4951285_0	1449353.JQMQ01000005_gene5066	2.869e-110	375.0	COG2721@1|root,COG2721@2|Bacteria,2GJC8@201174|Actinobacteria	201174|Actinobacteria	G	D-galactarate dehydratase Altronate	-	-	4.2.1.42,4.2.1.7	ko:K01685,ko:K01708	ko00040,ko00053,ko01100,map00040,map00053,map01100	M00631	R01540,R05608	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
CMS3_k127_4951285_1	502025.Hoch_1711	1.238e-70	254.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria	1224|Proteobacteria	M	PFAM Formylglycine-generating sulfatase enzyme	-	-	2.7.11.1	ko:K11912,ko:K20333	ko02024,ko02025,ko03070,map02024,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase,PEGA,Pkinase,TIR_2
CMS3_k127_4957909_0	439235.Dalk_1373	5.068e-05	54.0	COG2165@1|root,COG2165@2|Bacteria,1R08V@1224|Proteobacteria,43CRK@68525|delta/epsilon subdivisions,2X7Z9@28221|Deltaproteobacteria,2MPM7@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	TIGRFAM prepilin-type N-terminal cleavage methylation domain	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS3_k127_4957923_1	1048983.EL17_05890	1.735e-14	85.0	COG4099@1|root,COG4099@2|Bacteria,4NFSH@976|Bacteroidetes,47M41@768503|Cytophagia	976|Bacteroidetes	S	Phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,DLH,Esterase,Peptidase_S9
CMS3_k127_4957923_0	1123256.KB907926_gene786	3.06e-23	104.0	COG0454@1|root,COG0454@2|Bacteria,1QTZ4@1224|Proteobacteria,1T2J8@1236|Gammaproteobacteria,1XDF9@135614|Xanthomonadales	135614|Xanthomonadales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_4992944_0	391625.PPSIR1_07842	1.146e-41	179.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YZ6I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_4998543_4	246197.MXAN_2610	2.886e-14	84.0	COG1470@1|root,COG1470@2|Bacteria,1QX8S@1224|Proteobacteria,431GQ@68525|delta/epsilon subdivisions,2WW7Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin	-	-	-	-	-	-	-	-	-	-	-	-	ASH,TMEM131_like
CMS3_k127_4998543_3	391625.PPSIR1_19664	2.256e-28	126.0	COG1470@1|root,COG1470@2|Bacteria,1Q21G@1224|Proteobacteria,437PA@68525|delta/epsilon subdivisions,2X2XJ@28221|Deltaproteobacteria,2YX5A@29|Myxococcales	28221|Deltaproteobacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4998543_0	502025.Hoch_5389	7.836e-174	557.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WKF2@28221|Deltaproteobacteria,2YWP2@29|Myxococcales	28221|Deltaproteobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	clsA	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
CMS3_k127_4998543_1	765952.PUV_00830	1.521e-104	353.0	COG0861@1|root,COG0861@2|Bacteria,2JGY6@204428|Chlamydiae	204428|Chlamydiae	P	Integral membrane protein TerC family	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
CMS3_k127_4998543_2	391625.PPSIR1_02641	3.692e-60	229.0	COG1028@1|root,COG1028@2|Bacteria,1N8G3@1224|Proteobacteria	1224|Proteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
CMS3_k127_4998543_5	502025.Hoch_5386	2.722e-10	62.0	COG2041@1|root,COG2041@2|Bacteria,1MWZK@1224|Proteobacteria,43AZC@68525|delta/epsilon subdivisions,2WPPS@28221|Deltaproteobacteria,2YZRW@29|Myxococcales	28221|Deltaproteobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
CMS3_k127_4998900_2	344747.PM8797T_24956	1.396e-28	124.0	COG1595@1|root,COG1595@2|Bacteria,2J2TS@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r4_2
CMS3_k127_4998900_0	292459.STH518	1.503e-86	297.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS3_k127_5011521_4	1396141.BATP01000021_gene172	7.945e-06	55.0	COG4262@1|root,COG4262@2|Bacteria,46WK6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5011521_1	1382315.JPOI01000001_gene449	1.61e-75	273.0	COG1194@1|root,COG1194@2|Bacteria,1TPUT@1239|Firmicutes,4H9UM@91061|Bacilli,1WEW0@129337|Geobacillus	91061|Bacilli	L	FES	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
CMS3_k127_5011521_2	1170562.Cal6303_1682	1.127e-61	222.0	COG1409@1|root,COG1409@2|Bacteria,1G1Z6@1117|Cyanobacteria,1HKKI@1161|Nostocales	1117|Cyanobacteria	S	TIGRFAM TIGR04168 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
CMS3_k127_5011521_3	1123508.JH636445_gene6517	1.614e-24	111.0	COG2802@1|root,COG2802@2|Bacteria,2J03T@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase S16, lon domain protein	-	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
CMS3_k127_5011521_0	521098.Aaci_2058	2.505e-118	392.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,2784A@186823|Alicyclobacillaceae	91061|Bacilli	I	Belongs to the thiolase family	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_5020525_1	526227.Mesil_2946	3.744e-75	256.0	COG0451@1|root,COG0451@2|Bacteria,1WMCY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM NAD dependent epimerase dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS3_k127_5020525_0	91464.S7335_4163	7.772e-122	404.0	COG1972@1|root,COG1972@2|Bacteria,1G3CA@1117|Cyanobacteria,1H2IS@1129|Synechococcus	1117|Cyanobacteria	U	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
CMS3_k127_5020525_2	935845.JADQ01000014_gene3439	3.205e-61	234.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,4HABP@91061|Bacilli,26TPG@186822|Paenibacillaceae	91061|Bacilli	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
CMS3_k127_5020525_5	485913.Krac_7942	0.0004736	50.0	COG1595@1|root,COG1595@2|Bacteria,2G6X7@200795|Chloroflexi	2|Bacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_5020525_3	575540.Isop_0068	4.229e-54	218.0	COG0515@1|root,COG3391@1|root,COG0515@2|Bacteria,COG3391@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_5020525_4	671143.DAMO_0253	6.178e-24	112.0	COG4552@1|root,COG4552@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_9,SCP2_2
CMS3_k127_5020972_1	1189612.A33Q_2740	1.937e-40	151.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes	976|Bacteroidetes	T	PFAM BNR Asp-box repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
CMS3_k127_5020972_2	1248916.ANFY01000003_gene954	1.193e-28	123.0	COG1595@1|root,COG1595@2|Bacteria,1PBHM@1224|Proteobacteria,2UB0K@28211|Alphaproteobacteria,2K75F@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5020972_0	926550.CLDAP_34780	2.166e-41	174.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114,HemolysinCabind,PPC,Peptidase_M8,Peptidase_S8,SLH
CMS3_k127_5029389_0	886293.Sinac_2761	5.127e-107	386.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IYTQ@203682|Planctomycetes	203682|Planctomycetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16
CMS3_k127_5029389_1	710696.Intca_0098	1.08e-20	91.0	COG2382@1|root,COG2382@2|Bacteria,2I844@201174|Actinobacteria,4FE3S@85021|Intrasporangiaceae	201174|Actinobacteria	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	DUF3327,Esterase
CMS3_k127_5031259_0	1291050.JAGE01000001_gene867	6.727e-151	507.0	COG0823@1|root,COG0823@2|Bacteria,1VP24@1239|Firmicutes,24WTQ@186801|Clostridia,3WN5Z@541000|Ruminococcaceae	186801|Clostridia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
CMS3_k127_5036228_0	269796.Rru_A1804	6.911e-90	302.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2JPV8@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1042 Acyl-CoA synthetase (NDP forming)	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
CMS3_k127_5036228_1	1121875.KB907546_gene2455	3.767e-27	128.0	COG2885@1|root,COG2885@2|Bacteria,4NKCW@976|Bacteroidetes,1HXSH@117743|Flavobacteriia	976|Bacteroidetes	M	PFAM Outer membrane protein, OmpA MotB, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
CMS3_k127_5036986_1	1123508.JH636444_gene5460	9.773e-302	965.0	COG2133@1|root,COG3828@1|root,COG2133@2|Bacteria,COG3828@2|Bacteria,2IYH1@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,Cytochrom_C,Cytochrome_CBB3,Laminin_G_3,ThuA
CMS3_k127_5036986_0	1185876.BN8_01964	0.0	1582.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,4NHMI@976|Bacteroidetes,47K6B@768503|Cytophagia	976|Bacteroidetes	CG	Membrane-bound dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,HEAT_2,PmoA
CMS3_k127_5036986_2	1293054.HSACCH_00502	1.598e-11	73.0	2EKJA@1|root,33E96@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5038956_1	1267533.KB906733_gene3472	4.468e-111	388.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,TPR_8
CMS3_k127_5038956_2	314230.DSM3645_11631	3.148e-45	170.0	COG1595@1|root,COG1595@2|Bacteria,2J3FS@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS3_k127_5038956_0	314345.SPV1_05467	1.084e-152	488.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria	1224|Proteobacteria	Q	COG1233 Phytoene dehydrogenase and related proteins	-	-	1.3.99.23,5.2.1.13	ko:K09516,ko:K09835	ko00830,ko00906,ko01100,ko01110,map00830,map00906,map01100,map01110	M00097	R07163,R07512	RC01835,RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
CMS3_k127_5042360_0	1267533.KB906739_gene2622	1.821e-57	204.0	COG1573@1|root,COG1573@2|Bacteria,3Y43G@57723|Acidobacteria,2JJ46@204432|Acidobacteriia	204432|Acidobacteriia	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS3_k127_5042360_1	575540.Isop_1114	2.553e-36	160.0	COG0457@1|root,COG1450@1|root,COG4796@1|root,COG0457@2|Bacteria,COG1450@2|Bacteria,COG4796@2|Bacteria,2IY62@203682|Planctomycetes	203682|Planctomycetes	NU	Belongs to the GSP D family	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin
CMS3_k127_5048929_3	502025.Hoch_2228	3.551e-68	244.0	COG1092@1|root,COG1092@2|Bacteria,1PUHQ@1224|Proteobacteria	1224|Proteobacteria	J	Belongs to the methyltransferase superfamily	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
CMS3_k127_5048929_0	661478.OP10G_0773	1.486e-264	843.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_5048929_1	1288963.ADIS_1259	3.091e-141	462.0	COG3119@1|root,COG3119@2|Bacteria,4NGPC@976|Bacteroidetes	976|Bacteroidetes	P	Pfam Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_5048929_4	402777.KB235904_gene3508	6.023e-17	96.0	COG1413@1|root,COG5635@1|root,COG1413@2|Bacteria,COG5635@2|Bacteria,1G2R4@1117|Cyanobacteria,1H8BH@1150|Oscillatoriales	1117|Cyanobacteria	CT	E-Z type HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,NACHT
CMS3_k127_5048929_5	1167006.UWK_00863	1.658e-12	81.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
CMS3_k127_5048929_2	760192.Halhy_5513	8.008e-76	276.0	COG3119@1|root,COG3119@2|Bacteria,4NEM3@976|Bacteroidetes	976|Bacteroidetes	P	Arylsulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_505676_1	658086.HMPREF0994_00059	1.036e-17	91.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,27IS0@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
CMS3_k127_505676_0	1304880.JAGB01000001_gene685	1.064e-67	244.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia	186801|Clostridia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
CMS3_k127_505676_2	452637.Oter_2953	1.552e-05	57.0	COG4888@1|root,COG4888@2|Bacteria,46UDG@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM ASPIC UnbV domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,UnbV_ASPIC,VCBS
CMS3_k127_5069592_5	590409.Dd586_2132	4.122e-08	63.0	COG0810@1|root,COG0810@2|Bacteria,1MXBE@1224|Proteobacteria,1RMI4@1236|Gammaproteobacteria,2JD56@204037|Dickeya	1236|Gammaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	tonB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0007154,GO:0007165,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0015688,GO:0015833,GO:0015889,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0016032,GO:0019058,GO:0019062,GO:0019904,GO:0022610,GO:0023052,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0031992,GO:0032991,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0042914,GO:0043213,GO:0044403,GO:0044406,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0044650,GO:0046813,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0051704,GO:0051716,GO:0060089,GO:0065007,GO:0071575,GO:0071702,GO:0071705,GO:0071944,GO:0098002,GO:0098552,GO:0098670,GO:0098796,GO:0098797,GO:1901678	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	iAPECO1_1312.APECO1_368,iEC55989_1330.EC55989_1350,iECABU_c1320.ECABU_c15340,iECNA114_1301.ECNA114_1423,iECO103_1326.ECO103_1353,iECP_1309.ECP_1300,iECSF_1327.ECSF_1233,iEcE24377_1341.EcE24377A_1410	TonB_C,TonB_N
CMS3_k127_5069592_6	335543.Sfum_1752	1.355e-07	66.0	2DN50@1|root,32VJ4@2|Bacteria,1N8HX@1224|Proteobacteria,42VGC@68525|delta/epsilon subdivisions,2WS94@28221|Deltaproteobacteria,2MS7V@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
CMS3_k127_5069592_3	247490.KSU1_C0524	1.251e-16	94.0	COG3225@1|root,COG3225@2|Bacteria,2J05Q@203682|Planctomycetes	203682|Planctomycetes	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
CMS3_k127_5069592_2	1396141.BATP01000006_gene5424	2.283e-28	128.0	COG1277@1|root,COG1277@2|Bacteria,46T0W@74201|Verrucomicrobia,2IU5C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
CMS3_k127_5069592_1	1403819.BATR01000154_gene5161	1.115e-82	287.0	COG1131@1|root,COG1131@2|Bacteria,46UAZ@74201|Verrucomicrobia,2ITJ7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS3_k127_5069592_0	237368.SCABRO_03963	2.379e-256	805.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
CMS3_k127_5069592_4	1191523.MROS_0679	1.537e-12	75.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS3_k127_507316_6	292459.STH2528	6.712e-08	62.0	COG1595@1|root,COG1595@2|Bacteria,1VD37@1239|Firmicutes,25BCE@186801|Clostridia	186801|Clostridia	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_507316_1	344747.PM8797T_11581	1.555e-141	457.0	COG4447@1|root,COG4447@2|Bacteria,2IXU6@203682|Planctomycetes	203682|Planctomycetes	L	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_507316_4	1245471.PCA10_51040	1.185e-26	111.0	COG1977@1|root,COG1977@2|Bacteria,1N6RG@1224|Proteobacteria,1SHV8@1236|Gammaproteobacteria,1YH12@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
CMS3_k127_507316_5	243090.RB7198	1.424e-13	76.0	COG3682@1|root,COG3682@2|Bacteria,2J0QT@203682|Planctomycetes	203682|Planctomycetes	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS3_k127_507316_0	756272.Plabr_1627	1.992e-175	595.0	COG2304@1|root,COG2304@2|Bacteria,2IYNV@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
CMS3_k127_507316_2	756272.Plabr_4809	1.015e-66	252.0	COG2304@1|root,COG2304@2|Bacteria,2J0CF@203682|Planctomycetes	203682|Planctomycetes	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA
CMS3_k127_507316_3	756272.Plabr_1426	1.163e-48	184.0	COG1721@1|root,COG1721@2|Bacteria,2J04M@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_5080635_1	1282360.ABAC460_16880	1.493e-06	58.0	COG4733@1|root,COG4733@2|Bacteria,1R40N@1224|Proteobacteria,2U3RB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5080635_0	314230.DSM3645_25427	3.17e-101	338.0	COG0657@1|root,COG0657@2|Bacteria,2IY98@203682|Planctomycetes	203682|Planctomycetes	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
CMS3_k127_5082446_0	696747.NIES39_C05180	1.559e-121	412.0	COG1520@1|root,COG2931@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,1GQUQ@1117|Cyanobacteria,1HBB3@1150|Oscillatoriales	1117|Cyanobacteria	G	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind
CMS3_k127_5082446_4	886293.Sinac_0043	0.0008324	47.0	COG1595@1|root,COG1595@2|Bacteria,2J3M4@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5082446_1	1121373.KB903643_gene3461	2.172e-21	109.0	COG2849@1|root,COG2849@2|Bacteria,4NMDX@976|Bacteroidetes,47PCS@768503|Cytophagia	976|Bacteroidetes	S	MORN repeat variant	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2
CMS3_k127_5082446_2	1210884.HG799466_gene12503	1.276e-16	94.0	COG1225@1|root,COG1225@2|Bacteria,2J3WP@203682|Planctomycetes	203682|Planctomycetes	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_5082446_3	1210884.HG799471_gene14665	3.915e-12	73.0	COG0515@1|root,COG0515@2|Bacteria	1210884.HG799471_gene14665|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5083797_0	648996.Theam_0589	3.708e-69	243.0	COG0436@1|root,COG0436@2|Bacteria,2G3PX@200783|Aquificae	200783|Aquificae	E	PFAM Aminotransferase class I and II	dapC	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS3_k127_5083797_1	1336233.JAEH01000015_gene3277	0.0008513	51.0	28MJ4@1|root,2ZAVQ@2|Bacteria,1R62K@1224|Proteobacteria,1RNQC@1236|Gammaproteobacteria,2QADS@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	VP2126	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5087262_0	1304874.JAFY01000002_gene850	1.434e-37	162.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
CMS3_k127_5087851_1	1200792.AKYF01000020_gene4915	4.461e-29	127.0	COG5552@1|root,COG5552@2|Bacteria,1VCIJ@1239|Firmicutes,4HKXG@91061|Bacilli,26Z0F@186822|Paenibacillaceae	91061|Bacilli	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
CMS3_k127_5087851_0	519989.ECTPHS_10019	3.336e-44	169.0	COG0742@1|root,COG0742@2|Bacteria,1MX8Z@1224|Proteobacteria,1RMIB@1236|Gammaproteobacteria,1WYUS@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the guanosine in position 1516 of 16S rRNA	rsmJ	-	2.1.1.242	ko:K15984	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SAM_MT
CMS3_k127_5100112_2	391625.PPSIR1_18662	4.084e-22	101.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	ble	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
CMS3_k127_5100112_1	1254432.SCE1572_34125	3.093e-73	253.0	COG2378@1|root,COG2378@2|Bacteria,1MXS8@1224|Proteobacteria,437YA@68525|delta/epsilon subdivisions,2X385@28221|Deltaproteobacteria,2YUSI@29|Myxococcales	28221|Deltaproteobacteria	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
CMS3_k127_5100112_0	522306.CAP2UW1_2482	4.277e-84	305.0	COG3831@1|root,COG3831@2|Bacteria,1N132@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5102524_1	316274.Haur_1515	1.386e-80	290.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	4.2.2.3	ko:K01729	ko00051,map00051	-	R03706	-	ko00000,ko00001,ko01000	-	-	-	Beta_helix,Chondroitinas_B
CMS3_k127_5102524_0	1283300.ATXB01000001_gene1058	5.689e-144	475.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1XFDA@135618|Methylococcales	135618|Methylococcales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
CMS3_k127_5102524_2	493475.GARC_4265	2.018e-15	84.0	COG2931@1|root,COG2982@1|root,COG4733@1|root,COG2931@2|Bacteria,COG2982@2|Bacteria,COG4733@2|Bacteria,1MU7T@1224|Proteobacteria,1S1HJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,DUF4214,DUF4347,He_PIG,HemolysinCabind,PATR,VCBS
CMS3_k127_5104542_3	56780.SYN_02341	8.86e-06	48.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,42UJ1@68525|delta/epsilon subdivisions,2WR2I@28221|Deltaproteobacteria,2MSCR@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,Pentapeptide
CMS3_k127_5104542_0	1254432.SCE1572_21885	3.072e-186	595.0	COG1012@1|root,COG1012@2|Bacteria,1MWD4@1224|Proteobacteria,439ZZ@68525|delta/epsilon subdivisions,2X4EZ@28221|Deltaproteobacteria,2YYW8@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.77,1.2.1.91,3.3.2.12	ko:K02618,ko:K15514	ko00360,ko00362,ko01120,map00360,map00362,map01120	-	R09554,R09820,R09836	RC00080,RC02667	ko00000,ko00001,ko01000	-	-	-	Aldedh
CMS3_k127_5104542_2	1122604.JONR01000002_gene1662	3.554e-16	85.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,1S3MU@1236|Gammaproteobacteria,1XC9S@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
CMS3_k127_5104542_1	292564.Cyagr_0790	5.141e-150	502.0	COG1429@1|root,COG1429@2|Bacteria,1G0W1@1117|Cyanobacteria,22S7I@167375|Cyanobium	1117|Cyanobacteria	H	magnesium chelatase	chlH	-	6.6.1.1	ko:K03403	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	CobN-Mg_chel,DUF3479
CMS3_k127_5109632_1	243231.GSU0623	4.209e-78	270.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42MCE@68525|delta/epsilon subdivisions,2WIYP@28221|Deltaproteobacteria,43U7K@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
CMS3_k127_5109632_4	472759.Nhal_3328	1.839e-53	212.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,1WXFS@135613|Chromatiales	1236|Gammaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_5109632_2	572477.Alvin_1782	4.614e-61	235.0	COG2348@1|root,COG2348@2|Bacteria,1MXFY@1224|Proteobacteria,1T22W@1236|Gammaproteobacteria,1X2NU@135613|Chromatiales	135613|Chromatiales	V	TIGRFAM FemAB-related protein, PEP-CTERM system-associated	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
CMS3_k127_5109632_0	861299.J421_5987	7.715e-134	451.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria	2|Bacteria	L	DNA ligase (ATP) activity	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
CMS3_k127_5109632_6	760192.Halhy_5312	1.298e-26	120.0	2DQP6@1|root,337VW@2|Bacteria,4P4EF@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF4240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4240
CMS3_k127_5109632_5	344747.PM8797T_00729	3.731e-51	205.0	COG0272@1|root,COG0457@1|root,COG0789@1|root,COG0272@2|Bacteria,COG0457@2|Bacteria,COG0789@2|Bacteria,2IZBY@203682|Planctomycetes	203682|Planctomycetes	K	O-linked GlcNAc transferase	-	-	-	-	-	-	-	-	-	-	-	-	BRCT,MerR_1,TPR_16
CMS3_k127_5109632_3	868595.Desca_1165	1.579e-57	213.0	COG1793@1|root,COG1793@2|Bacteria,1U8ME@1239|Firmicutes,24B1F@186801|Clostridia,265FU@186807|Peptococcaceae	186801|Clostridia	L	PFAM ATP dependent DNA ligase	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
CMS3_k127_5109632_7	706587.Desti_2360	0.0002209	47.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
CMS3_k127_5110448_0	1129794.C427_1223	3.447e-81	293.0	COG2706@1|root,COG3391@1|root,COG3637@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,COG3637@2|Bacteria,1QWRQ@1224|Proteobacteria,1T4S3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5119880_2	1379270.AUXF01000001_gene1941	1.549e-68	256.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZUHA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
CMS3_k127_5119880_3	1123508.JH636453_gene5810	6.663e-49	189.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS3_k127_5119880_4	1122611.KB904018_gene7079	6.936e-14	85.0	COG2755@1|root,COG3055@1|root,COG3209@1|root,COG2755@2|Bacteria,COG3055@2|Bacteria,COG3209@2|Bacteria,2IH7Z@201174|Actinobacteria,4EKQ8@85012|Streptosporangiales	201174|Actinobacteria	M	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS3_k127_5119880_5	1195236.CTER_0559	1.113e-08	69.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia,3WIWU@541000|Ruminococcaceae	186801|Clostridia	O	Subtilase family	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,LRR_5,PPC,Peptidase_S8
CMS3_k127_5119880_1	891968.Anamo_1212	7.417e-71	253.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	cyoE	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2
CMS3_k127_5119880_0	1123508.JH636452_gene7057	1.062e-75	267.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,2J2J0@203682|Planctomycetes	203682|Planctomycetes	S	Vault protein inter-alpha-trypsin domain	-	-	-	-	-	-	-	-	-	-	-	-	VIT,VWA_3
CMS3_k127_5121271_2	530564.Psta_2500	4.294e-54	200.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_8,WD40
CMS3_k127_5121271_1	595460.RRSWK_03108	2.035e-115	388.0	COG1520@1|root,COG1520@2|Bacteria,2IWR8@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_5121271_0	1403819.BATR01000027_gene881	3.596e-181	578.0	COG4948@1|root,COG4948@2|Bacteria,46VZI@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
CMS3_k127_5121271_3	314230.DSM3645_10062	8.161e-44	166.0	COG1889@1|root,COG1889@2|Bacteria,2J51S@203682|Planctomycetes	203682|Planctomycetes	J	Fibrillarin	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
CMS3_k127_5125526_1	204669.Acid345_1602	8.623e-06	55.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS3_k127_5125526_0	349124.Hhal_1970	3.418e-231	726.0	COG0388@1|root,COG0388@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,1WW4Z@135613|Chromatiales	135613|Chromatiales	K	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
CMS3_k127_5129179_1	247490.KSU1_B0092	1.616e-92	312.0	COG0480@1|root,COG0480@2|Bacteria,2IX5V@203682|Planctomycetes	203682|Planctomycetes	J	COG0480 Translation elongation factors	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS3_k127_5129179_0	1499967.BAYZ01000027_gene1789	9.207e-126	411.0	COG2805@1|root,COG2805@2|Bacteria,2NNR7@2323|unclassified Bacteria	2|Bacteria	NU	Type II/IV secretion system protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS3_k127_5141162_0	1417296.U879_06690	5.999e-193	618.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
CMS3_k127_5141162_1	204669.Acid345_4191	8.693e-111	370.0	COG1680@1|root,COG1680@2|Bacteria,3Y6TE@57723|Acidobacteria,2JM4R@204432|Acidobacteriia	204432|Acidobacteriia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_5144711_0	661478.OP10G_2311	7.978e-77	269.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	nosF	-	-	ko:K01990,ko:K19340	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC_tran
CMS3_k127_5144711_1	1210884.HG799466_gene12490	0.000174	53.0	2DUH7@1|root,33QMM@2|Bacteria,2J2B0@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_515023_2	575540.Isop_3569	1.951e-45	173.0	2BXEQ@1|root,33IN8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_515023_3	384676.PSEEN1727	6.165e-12	78.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	von willebrand factor, type A	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
CMS3_k127_515023_0	575540.Isop_3571	5.105e-100	339.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
CMS3_k127_515023_1	575540.Isop_3572	1.892e-52	191.0	2ECWJ@1|root,336TU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_515023_4	575540.Isop_3573	1.324e-11	77.0	2DUKG@1|root,33R4D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5154821_0	1192034.CAP_5642	3.033e-124	416.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,42P8D@68525|delta/epsilon subdivisions,2WMH1@28221|Deltaproteobacteria,2YWWP@29|Myxococcales	28221|Deltaproteobacteria	KLT	COG0515 Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,Pkinase_Tyr,WD40
CMS3_k127_5154821_1	448385.sce4588	2.007e-103	359.0	COG1716@1|root,COG3829@1|root,COG1716@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,439RU@68525|delta/epsilon subdivisions,2X54N@28221|Deltaproteobacteria,2Z03Z@29|Myxococcales	28221|Deltaproteobacteria	K	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Sigma54_activat
CMS3_k127_5157870_0	395493.BegalDRAFT_1906	3.874e-33	148.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria	395493.BegalDRAFT_1906|-	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5166763_1	264732.Moth_1948	1.735e-87	299.0	COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,2482W@186801|Clostridia,42FNN@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Aspartate glutamate uridylate kinase	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
CMS3_k127_5166763_0	381764.Fnod_0782	1.27e-143	471.0	COG2403@1|root,COG2403@2|Bacteria,2GCJ5@200918|Thermotogae	200918|Thermotogae	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5166763_2	55529.EKX36503	3.577e-78	285.0	COG0448@1|root,KOG1504@2759|Eukaryota	2759|Eukaryota	G	ornithine carbamoyltransferase activity	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS3_k127_5168112_0	1121918.ARWE01000001_gene1153	1.071e-109	377.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2WJ7M@28221|Deltaproteobacteria,43S3S@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	ABC transporter transmembrane region	msbA	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_5169231_0	1123242.JH636435_gene2890	3.925e-12	79.0	COG2304@1|root,COG2304@2|Bacteria,2J43F@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_3
CMS3_k127_5169729_2	215803.DB30_0203	1.045e-40	164.0	2EJXK@1|root,33DN8@2|Bacteria,1NUR9@1224|Proteobacteria,439D3@68525|delta/epsilon subdivisions,2X4MR@28221|Deltaproteobacteria,2YZ9I@29|Myxococcales	28221|Deltaproteobacteria	S	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_5169729_0	338963.Pcar_2896	1.36e-150	485.0	COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,42QD3@68525|delta/epsilon subdivisions,2WM12@28221|Deltaproteobacteria,43W16@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
CMS3_k127_5169729_3	1121396.KB893065_gene1625	1.265e-29	119.0	2BEKE@1|root,328BU@2|Bacteria,1RM2J@1224|Proteobacteria,42TNQ@68525|delta/epsilon subdivisions,2WQG6@28221|Deltaproteobacteria,2MNP3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
CMS3_k127_5172436_3	582402.Hbal_2626	1.085e-09	68.0	COG1228@1|root,COG1228@2|Bacteria,1MXQX@1224|Proteobacteria,2U1V8@28211|Alphaproteobacteria,43W9D@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
CMS3_k127_5172436_2	1229781.C272_04925	1.968e-31	142.0	COG1228@1|root,COG1228@2|Bacteria,2I9IW@201174|Actinobacteria,4F8ER@85019|Brevibacteriaceae	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
CMS3_k127_5172436_0	1121020.JIAG01000001_gene1061	2.482e-59	222.0	COG1228@1|root,COG1228@2|Bacteria,2I9IW@201174|Actinobacteria,1W8Q4@1268|Micrococcaceae	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
CMS3_k127_5172436_1	575540.Isop_1260	6.411e-56	213.0	COG1228@1|root,COG1228@2|Bacteria,2J0GA@203682|Planctomycetes	2|Bacteria	Q	COGs COG1228 Imidazolonepropionase and related amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
CMS3_k127_5195002_1	1162668.LFE_0008	1.066e-62	220.0	COG0260@1|root,COG0260@2|Bacteria,3J0X7@40117|Nitrospirae	40117|Nitrospirae	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
CMS3_k127_5195002_3	313624.NSP_44690	9.269e-45	165.0	COG0614@1|root,COG0614@2|Bacteria,1G71C@1117|Cyanobacteria,1HP4K@1161|Nostocales	1117|Cyanobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
CMS3_k127_5195002_2	688269.Theth_1889	4.036e-50	185.0	COG0205@1|root,COG0205@2|Bacteria,2GC8H@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
CMS3_k127_5195002_0	1499967.BAYZ01000014_gene6356	5.388e-71	245.0	COG0205@1|root,COG0205@2|Bacteria,2NNXU@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135	2.7.1.11,2.7.1.90	ko:K00850,ko:K00895,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
CMS3_k127_5196697_0	1125863.JAFN01000001_gene663	0.0	1394.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1149@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1149@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	poR	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
CMS3_k127_5196697_1	1121920.AUAU01000008_gene1590	3.839e-60	213.0	COG0167@1|root,COG0167@2|Bacteria,3Y464@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
CMS3_k127_52025_0	1123508.JH636444_gene5664	8.661e-69	243.0	COG0500@1|root,COG2226@2|Bacteria,2IZR2@203682|Planctomycetes	203682|Planctomycetes	Q	COG2226 Methylase involved in ubiquinone menaquinone biosynthesis	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
CMS3_k127_52025_1	448385.sce6966	2.117e-18	92.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P6D@68525|delta/epsilon subdivisions,2WM1P@28221|Deltaproteobacteria,2YY7P@29|Myxococcales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_5209393_1	575540.Isop_3729	2.339e-41	159.0	COG2088@1|root,COG2088@2|Bacteria,2IZR8@203682|Planctomycetes	203682|Planctomycetes	D	Belongs to the SpoVG family	-	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
CMS3_k127_5209393_3	136993.KB900626_gene1382	3.113e-33	142.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2TUFV@28211|Alphaproteobacteria,36Y3Y@31993|Methylocystaceae	28211|Alphaproteobacteria	I	GHMP kinases N terminal domain	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
CMS3_k127_5209393_0	1382356.JQMP01000001_gene1201	2.796e-72	253.0	COG0414@1|root,COG0414@2|Bacteria,2G64N@200795|Chloroflexi,27XI9@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
CMS3_k127_5209393_4	1121033.AUCF01000017_gene3749	2.308e-25	119.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2U8D6@28211|Alphaproteobacteria,2JTRD@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	-	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
CMS3_k127_5209393_2	243090.RB3820	8.793e-34	144.0	COG1183@1|root,COG1183@2|Bacteria,2IZHR@203682|Planctomycetes	203682|Planctomycetes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
CMS3_k127_521915_3	298654.FraEuI1c_0638	9.753e-27	119.0	COG2120@1|root,COG2120@2|Bacteria,2GWZT@201174|Actinobacteria,4EX3A@85013|Frankiales	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS3_k127_521915_2	1454202.PPBDW_130661___1	5.469e-42	162.0	COG0726@1|root,COG0726@2|Bacteria,1PJQG@1224|Proteobacteria,1S2K1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	xylanase chitin deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
CMS3_k127_521915_0	483218.BACPEC_02368	8.401e-237	748.0	COG2192@1|root,COG2192@2|Bacteria,1TS7M@1239|Firmicutes,2488M@186801|Clostridia	186801|Clostridia	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS3_k127_521915_1	1254432.SCE1572_00900	6.522e-44	173.0	COG2192@1|root,COG2755@1|root,COG2192@2|Bacteria,COG2755@2|Bacteria,1MWBA@1224|Proteobacteria,42N15@68525|delta/epsilon subdivisions,2WJ0Y@28221|Deltaproteobacteria,2YYSN@29|Myxococcales	28221|Deltaproteobacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS3_k127_521915_5	1267535.KB906767_gene4549	0.0003273	53.0	COG3420@1|root,COG3420@2|Bacteria,3Y6PA@57723|Acidobacteria,2JMNE@204432|Acidobacteriia	204432|Acidobacteriia	P	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS3_k127_521915_4	1464048.JNZS01000020_gene2243	2.063e-12	80.0	COG3266@1|root,COG4719@1|root,COG3266@2|Bacteria,COG4719@2|Bacteria	2|Bacteria	GM	domain, Protein	pcm	-	2.1.1.77,2.7.7.7	ko:K00573,ko:K02335,ko:K03980,ko:K20276,ko:K20541,ko:K21397	ko00230,ko00240,ko01100,ko02024,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map02024,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko01011,ko02000,ko03032,ko03400	2.A.66.4,3.A.1,4.D.3.1.6	-	-	DUF11
CMS3_k127_5220041_1	671143.DAMO_1654	3.658e-30	138.0	COG0542@1|root,COG0542@2|Bacteria,2NNKN@2323|unclassified Bacteria	2|Bacteria	O	C-terminal, D2-small domain, of ClpB protein	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
CMS3_k127_5220041_0	761193.Runsl_2490	2.297e-86	308.0	COG3876@1|root,COG3876@2|Bacteria,4P1CP@976|Bacteroidetes,47U2C@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
CMS3_k127_5220041_2	391625.PPSIR1_07263	6.64e-07	63.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5220041_3	1242864.D187_003683	5.563e-05	56.0	COG4932@1|root,COG4932@2|Bacteria,1NXIX@1224|Proteobacteria,430KM@68525|delta/epsilon subdivisions,2WVSB@28221|Deltaproteobacteria,2YYGY@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_5230012_2	886293.Sinac_2761	1.723e-73	284.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IYTQ@203682|Planctomycetes	203682|Planctomycetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16
CMS3_k127_5230012_1	1123073.KB899242_gene1321	5.665e-138	458.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria,1XA6G@135614|Xanthomonadales	135614|Xanthomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5230012_0	344747.PM8797T_13278	1.215e-143	473.0	COG3119@1|root,COG3119@2|Bacteria,2IX9T@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS3_k127_5230012_3	156978.CIMIT_03740	3.954e-07	64.0	COG4932@1|root,COG4932@2|Bacteria,2I5A4@201174|Actinobacteria,22RHI@1653|Corynebacteriaceae	201174|Actinobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Rib
CMS3_k127_5230966_1	471857.Svir_08210	1.831e-36	144.0	COG0517@1|root,COG0517@2|Bacteria,2IHPB@201174|Actinobacteria,4E4MC@85010|Pseudonocardiales	201174|Actinobacteria	S	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS3_k127_5230966_2	525257.HMPREF0204_15151	5.877e-15	83.0	COG1633@1|root,COG1633@2|Bacteria,4NP59@976|Bacteroidetes,1I1YJ@117743|Flavobacteriia,3ZRS5@59732|Chryseobacterium	976|Bacteroidetes	S	Domain of unknown function (DUF2383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2383
CMS3_k127_5230966_0	398767.Glov_2994	3.684e-88	317.0	2DUAU@1|root,33PQN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5230966_4	1408433.JHXV01000008_gene89	0.0002926	54.0	COG1357@1|root,COG3291@1|root,COG1357@2|Bacteria,COG3291@2|Bacteria,4NMVW@976|Bacteroidetes,1I1JQ@117743|Flavobacteriia,2PBI2@246874|Cryomorphaceae	976|Bacteroidetes	G	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS3_k127_5230966_3	365528.KB891225_gene1241	1.027e-08	65.0	COG0443@1|root,COG2319@1|root,COG0443@2|Bacteria,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria,4EUR9@85013|Frankiales	2|Bacteria	P	WD-40 repeat-containing protein	-	-	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70,WD40
CMS3_k127_5234706_4	644076.SCH4B_1510	1.718e-58	215.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TTAY@28211|Alphaproteobacteria,4NAIR@97050|Ruegeria	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS3_k127_5234706_6	1499967.BAYZ01000024_gene282	2.099e-46	192.0	COG5373@1|root,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	Otg1	-	-	-	-	-	-	-	-	-	-	-	DUF2339,DUF4167
CMS3_k127_5234706_3	1502852.FG94_02952	9.335e-72	270.0	COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2VK2Y@28216|Betaproteobacteria,473YF@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	N-formylglutamate amidohydrolase	hutG	-	3.5.1.68,3.5.3.8	ko:K01458,ko:K01479	ko00340,ko00630,ko01100,map00340,map00630,map01100	M00045	R00525,R02285	RC00165,RC00221,RC00323,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	FGase
CMS3_k127_5234706_0	1121033.AUCF01000033_gene3613	9.1e-129	426.0	COG0402@1|root,COG0402@2|Bacteria,1MUFE@1224|Proteobacteria,2TR3A@28211|Alphaproteobacteria,2JPEJ@204441|Rhodospirillales	204441|Rhodospirillales	F	Amidohydrolase family	-	-	3.5.3.13	ko:K05603	ko00340,map00340	-	R02286	RC00682	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
CMS3_k127_5234706_1	330214.NIDE1574	3.177e-114	398.0	COG2896@1|root,COG2896@2|Bacteria,3J0PB@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_14,Mob_synth_C,Radical_SAM
CMS3_k127_5234706_2	861299.J421_2550	2.819e-105	356.0	COG0266@1|root,COG0266@2|Bacteria,1ZUR3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Formamidopyrimidine-DNA glycosylase N-terminal domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
CMS3_k127_5234706_5	1336233.JAEH01000021_gene3390	1.102e-50	189.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,1S0GN@1236|Gammaproteobacteria,2QA7K@267890|Shewanellaceae	1236|Gammaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	csgA	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_5234706_7	1232410.KI421422_gene1946	8.45e-19	97.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,42WIA@68525|delta/epsilon subdivisions,2WS9S@28221|Deltaproteobacteria,43VW7@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM thioesterase superfamily protein	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
CMS3_k127_5248715_1	1183438.GKIL_1369	4.512e-11	76.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
CMS3_k127_5248715_2	1283299.AUKG01000002_gene4566	4.371e-05	53.0	COG5306@1|root,COG5306@2|Bacteria	2|Bacteria	-	-	exbB2	-	-	ko:K03561,ko:K12287	-	-	-	-	ko00000,ko02000,ko02044	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
CMS3_k127_5248715_0	1150600.ADIARSV_2992	1.946e-12	74.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans,SLH,SQHop_cyclase_C,SQHop_cyclase_N
CMS3_k127_5260080_0	237368.SCABRO_03561	2.297e-101	338.0	COG1090@1|root,COG1090@2|Bacteria,2IXEW@203682|Planctomycetes	203682|Planctomycetes	S	epimerase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase,Polyketide_cyc
CMS3_k127_5260080_1	595460.RRSWK_06361	6.638e-86	296.0	COG2335@1|root,COG2335@2|Bacteria,2IZDI@203682|Planctomycetes	203682|Planctomycetes	M	COG2335 Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
CMS3_k127_5260080_3	1312959.KI914690_gene2843	6.106e-37	153.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,1W7FS@1268|Micrococcaceae	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS3_k127_5260080_2	196367.JNFG01000004_gene5593	1.279e-40	162.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria,1K59U@119060|Burkholderiaceae	28216|Betaproteobacteria	K	B12 binding domain	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
CMS3_k127_5260080_4	530564.Psta_2352	7.492e-36	154.0	COG4276@1|root,COG4276@2|Bacteria,2J0FI@203682|Planctomycetes	203682|Planctomycetes	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
CMS3_k127_5261228_0	595460.RRSWK_02582	7.029e-76	278.0	COG4826@1|root,COG4826@2|Bacteria,2J2TV@203682|Planctomycetes	203682|Planctomycetes	O	SERine  Proteinase INhibitors	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
CMS3_k127_526738_1	314230.DSM3645_09257	5.701e-175	572.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,2IX1D@203682|Planctomycetes	203682|Planctomycetes	H	May be the GTPase, regulating ATP sulfurylase activity	cysN	GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0044237	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
CMS3_k127_526738_3	1382359.JIAL01000001_gene2889	9.21e-133	428.0	COG0175@1|root,COG0175@2|Bacteria,3Y36I@57723|Acidobacteria,2JHYJ@204432|Acidobacteriia	204432|Acidobacteriia	EH	Phosphoadenosine phosphosulfate reductase family	-	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
CMS3_k127_526738_7	1499967.BAYZ01000074_gene2111	0.0004358	48.0	2EGPU@1|root,31UHW@2|Bacteria,2NRWE@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_526738_5	886293.Sinac_7434	3.508e-12	73.0	2BR4A@1|root,32K29@2|Bacteria,2J1BQ@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_526738_0	344747.PM8797T_18941	1.294e-244	774.0	COG2192@1|root,COG2192@2|Bacteria,2IYCS@203682|Planctomycetes	203682|Planctomycetes	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS3_k127_526738_2	864051.BurJ1DRAFT_2767	2.076e-161	536.0	COG5492@1|root,COG5492@2|Bacteria,1QY8X@1224|Proteobacteria,2VJ6A@28216|Betaproteobacteria	28216|Betaproteobacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_526738_6	1150599.MPHLEI_02793	3.791e-08	67.0	COG3209@1|root,COG3209@2|Bacteria,2I60K@201174|Actinobacteria,2375A@1762|Mycobacteriaceae	201174|Actinobacteria	M	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,RCC1_2
CMS3_k127_526738_4	1242864.D187_003284	1.316e-52	191.0	COG5646@1|root,COG5646@2|Bacteria	2|Bacteria	S	Domain of unknown function (DU1801)	XK27_02315	-	-	-	-	-	-	-	-	-	-	-	DUF1801
CMS3_k127_5269289_0	913325.N799_05665	1.479e-45	186.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RY6M@1236|Gammaproteobacteria,1X6RZ@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K19340	ko02010,map02010	M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.132.2	-	-	ABC_tran
CMS3_k127_5269289_3	583355.Caka_2630	6.814e-08	63.0	2E57Z@1|root,3300G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5269289_1	1217718.ALOU01000007_gene1304	2.607e-39	153.0	2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,2VSQ3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
CMS3_k127_5269289_2	1434325.AZQN01000011_gene3742	6.886e-09	65.0	28N6F@1|root,2ZBBB@2|Bacteria,4NGM1@976|Bacteroidetes,47P0U@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5294108_1	1122918.KB907284_gene1224	1.347e-23	113.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,4HB60@91061|Bacilli,26QTA@186822|Paenibacillaceae	91061|Bacilli	K	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
CMS3_k127_5294108_0	1223410.KN050846_gene2681	3.568e-58	220.0	COG4977@1|root,COG4977@2|Bacteria,4NHHE@976|Bacteroidetes,1HXNU@117743|Flavobacteriia	976|Bacteroidetes	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
CMS3_k127_5294821_0	765869.BDW_02665	1.095e-145	476.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2MTJR@213481|Bdellovibrionales,2WIR7@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	pdhD	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
CMS3_k127_5294821_3	1254432.SCE1572_45980	4.74e-99	335.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42NW8@68525|delta/epsilon subdivisions,2WJY1@28221|Deltaproteobacteria,2YY6R@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase E1 component	bkdA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
CMS3_k127_5294821_2	292459.STH413	3.175e-117	391.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,247Q5@186801|Clostridia	186801|Clostridia	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12,2.3.1.168	ko:K00627,ko:K09699	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200	M00036,M00307	R00209,R02569,R02662,R03174,R04097,R10998	RC00004,RC02727,RC02742,RC02857,RC02870	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,CMD,E3_binding
CMS3_k127_5294821_1	404589.Anae109_1994	2.113e-118	386.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42N06@68525|delta/epsilon subdivisions,2WK5N@28221|Deltaproteobacteria,2YTX4@29|Myxococcales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	bkdB	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS3_k127_5309262_7	1123065.ATWL01000006_gene2307	1.472e-21	102.0	COG1082@1|root,COG1082@2|Bacteria,2I94Z@201174|Actinobacteria	201174|Actinobacteria	G	BNR repeat-containing family member	-	-	-	-	-	-	-	-	-	-	-	-	BNR_4
CMS3_k127_5309262_4	452637.Oter_4337	5.812e-70	243.0	COG5012@1|root,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	mtbC	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
CMS3_k127_5309262_1	452637.Oter_4341	6.782e-116	399.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,46VH9@74201|Verrucomicrobia,3K8AT@414999|Opitutae	414999|Opitutae	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445
CMS3_k127_5309262_6	452637.Oter_4340	3.572e-22	104.0	COG1410@1|root,COG1410@2|Bacteria,46UVC@74201|Verrucomicrobia	74201|Verrucomicrobia	E	methionine synthase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5309262_2	452637.Oter_4332	4.593e-90	310.0	COG0646@1|root,COG0646@2|Bacteria,46SYT@74201|Verrucomicrobia,3K9JH@414999|Opitutae	414999|Opitutae	E	Homocysteine S-methyltransferase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
CMS3_k127_5309262_3	697281.Mahau_2725	3.447e-84	299.0	COG0407@1|root,COG0407@2|Bacteria,1TR8Q@1239|Firmicutes,24B2U@186801|Clostridia,42IQ4@68295|Thermoanaerobacterales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	2.1.1.246,4.1.1.37	ko:K01599,ko:K14080	ko00680,ko00860,ko01100,ko01110,ko01120,ko01200,map00680,map00860,map01100,map01110,map01120,map01200	M00121,M00356	R03197,R04972,R09098,R10000	RC00035,RC00872,RC01144,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
CMS3_k127_5309262_0	314278.NB231_07462	5.413e-154	505.0	COG2230@1|root,COG2230@2|Bacteria,1QY55@1224|Proteobacteria,1RYEN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
CMS3_k127_5309262_5	886293.Sinac_6944	1.804e-53	194.0	COG2755@1|root,COG2755@2|Bacteria,2IWSK@203682|Planctomycetes	203682|Planctomycetes	E	N-terminus of Esterase_SGNH_hydro-type	-	-	-	-	-	-	-	-	-	-	-	-	GxDLY,Lipase_GDSL_3
CMS3_k127_5311257_6	448385.sce6583	3.242e-05	49.0	COG0438@1|root,COG0438@2|Bacteria,1MWSZ@1224|Proteobacteria,42NYZ@68525|delta/epsilon subdivisions,2WK9U@28221|Deltaproteobacteria,2Z080@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,MannoseP_isomer
CMS3_k127_5311257_0	671143.DAMO_2498	5.784e-125	413.0	COG1180@1|root,COG1180@2|Bacteria,2NP82@2323|unclassified Bacteria	2|Bacteria	O	Radical SAM superfamily	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS3_k127_5311257_4	595460.RRSWK_04484	3.094e-25	121.0	COG2267@1|root,COG2267@2|Bacteria,2J3M9@203682|Planctomycetes	203682|Planctomycetes	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5311257_2	1123242.JH636434_gene4760	5.395e-36	155.0	COG1354@1|root,COG1354@2|Bacteria,2IZIR@203682|Planctomycetes	203682|Planctomycetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
CMS3_k127_5311257_1	867845.KI911784_gene726	5.682e-46	177.0	COG1408@1|root,COG1408@2|Bacteria,2G6VC@200795|Chloroflexi,375MG@32061|Chloroflexia	32061|Chloroflexia	S	PFAM metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
CMS3_k127_5311257_3	502025.Hoch_4877	2.041e-30	137.0	COG2856@1|root,COG2856@2|Bacteria,1PADA@1224|Proteobacteria,434WD@68525|delta/epsilon subdivisions,2WZ7C@28221|Deltaproteobacteria,2Z1HG@29|Myxococcales	28221|Deltaproteobacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5311257_5	1210884.HG799462_gene8052	1.066e-07	62.0	COG1277@1|root,COG1277@2|Bacteria,2J3V9@203682|Planctomycetes	203682|Planctomycetes	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5312600_0	42099.EPrPV00000017225	7.733e-58	202.0	COG1250@1|root,KOG2304@2759|Eukaryota,1MC1W@121069|Pythiales	121069|Pythiales	I	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N
CMS3_k127_5312600_2	234267.Acid_5128	1.585e-21	108.0	29V32@1|root,30GGD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5312600_1	1283283.ATXA01000010_gene4586	8.086e-36	147.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_11,Methyltransf_25
CMS3_k127_5314337_0	240016.ABIZ01000001_gene3314	1e-73	268.0	COG2010@1|root,COG3241@1|root,COG2010@2|Bacteria,COG3241@2|Bacteria,46WAE@74201|Verrucomicrobia,2IVQW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	PA14	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cytochrome_CBB3,PA14
CMS3_k127_5314337_2	765869.BDW_01005	8.766e-05	55.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,42M7N@68525|delta/epsilon subdivisions,2MUQJ@213481|Bdellovibrionales,2WM4F@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.10.3.10,1.9.3.1	ko:K02275,ko:K02297	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX2,COX2_TM,COX_ARM,Cytochrom_C,Cytochrome_CBB3
CMS3_k127_5314337_1	761193.Runsl_2490	2.158e-08	58.0	COG3876@1|root,COG3876@2|Bacteria,4P1CP@976|Bacteroidetes,47U2C@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
CMS3_k127_5315527_0	1122182.KB903833_gene5429	4.218e-119	415.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,2I9U6@201174|Actinobacteria,4DH83@85008|Micromonosporales	201174|Actinobacteria	O	Proprotein convertase P-domain	-	-	-	-	-	-	-	-	-	-	-	-	P_proprotein,Peptidase_S8
CMS3_k127_5337212_0	530564.Psta_2696	5.363e-63	244.0	COG2304@1|root,COG2304@2|Bacteria,2IYCE@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
CMS3_k127_5337212_1	1210884.HG799464_gene10585	2.84e-05	59.0	COG1520@1|root,COG1520@2|Bacteria,2IXF0@203682|Planctomycetes	203682|Planctomycetes	S	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_5348431_0	314278.NB231_03600	2.879e-60	222.0	COG3746@1|root,COG3746@2|Bacteria,1RAJS@1224|Proteobacteria,1S3ID@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
CMS3_k127_5349213_1	62928.azo0278	1.082e-05	58.0	2EFNF@1|root,339EK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5349213_0	1123368.AUIS01000008_gene2246	1.364e-87	296.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Acyl-CoA synthetase (NDP forming)	yfiQ	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
CMS3_k127_5355514_2	886293.Sinac_6491	0.0006055	49.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	GerE,Sigma70_r2,Sigma70_r4_2,Whib
CMS3_k127_5355514_0	243090.RB13271	2.793e-112	384.0	COG1181@1|root,COG1181@2|Bacteria,2IZEV@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
CMS3_k127_5355514_1	243090.RB13273	4.587e-84	286.0	COG4307@1|root,COG4307@2|Bacteria	2|Bacteria	T	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
CMS3_k127_5359629_0	1242864.D187_005962	6.169e-153	501.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,4397Z@68525|delta/epsilon subdivisions,2X4F1@28221|Deltaproteobacteria,2YYWE@29|Myxococcales	1224|Proteobacteria	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
CMS3_k127_5359629_1	1158292.JPOE01000002_gene2869	3.67e-73	257.0	28J8Y@1|root,2Z943@2|Bacteria,1REXC@1224|Proteobacteria,2W0TK@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
CMS3_k127_5359629_2	864051.BurJ1DRAFT_3207	2.134e-05	51.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,2VQRJ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
CMS3_k127_5368804_2	1443665.JACA01000003_gene913	0.0006139	49.0	COG1595@1|root,COG1595@2|Bacteria,4NEHC@976|Bacteroidetes,1HYVK@117743|Flavobacteriia,2YHU5@290174|Aquimarina	976|Bacteroidetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5368804_0	886293.Sinac_3627	6.073e-76	286.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_8,WD40
CMS3_k127_5368804_1	331113.SNE_A09620	3.152e-46	170.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS3_k127_5370763_0	314230.DSM3645_26034	3.28e-105	350.0	COG0329@1|root,COG0329@2|Bacteria,2J23B@203682|Planctomycetes	203682|Planctomycetes	H	Dihydrodipicolinate synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	DHDPS
CMS3_k127_5370763_1	595460.RRSWK_04471	6.508e-77	271.0	COG0591@1|root,COG3055@1|root,COG0591@2|Bacteria,COG3055@2|Bacteria,2IX6M@203682|Planctomycetes	203682|Planctomycetes	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,SSF
CMS3_k127_5372240_0	1177179.A11A3_09035	3.278e-42	164.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1XHBR@135619|Oceanospirillales	135619|Oceanospirillales	S	stress-induced protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
CMS3_k127_5372240_1	1341157.RF007C_04030	3.869e-41	168.0	COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia,3WIUW@541000|Ruminococcaceae	186801|Clostridia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
CMS3_k127_5372240_2	1504981.KO116_0489	9.133e-32	131.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1XIHN@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
CMS3_k127_5372240_3	1297742.A176_00181	7.083e-17	87.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2YURF@29|Myxococcales	28221|Deltaproteobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
CMS3_k127_5396349_3	743721.Psesu_2494	3.864e-14	79.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1X3II@135614|Xanthomonadales	135614|Xanthomonadales	T	CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_5396349_2	748449.Halha_1779	4.595e-27	127.0	COG1388@1|root,COG4796@1|root,COG1388@2|Bacteria,COG4796@2|Bacteria,1UK31@1239|Firmicutes,24PRP@186801|Clostridia,3WBPW@53433|Halanaerobiales	186801|Clostridia	U	Type II and III secretion system protein	-	-	-	ko:K02453,ko:K02666	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	LysM,Secretin,Secretin_N
CMS3_k127_5396349_0	387092.NIS_0272	5.723e-238	760.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2YMB2@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS3_k127_5396349_1	404589.Anae109_2957	2.94e-115	387.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2WK79@28221|Deltaproteobacteria,2YV9G@29|Myxococcales	28221|Deltaproteobacteria	H	aminotransferase	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
CMS3_k127_5396349_5	652103.Rpdx1_1119	5.585e-10	68.0	2CP7W@1|root,32SIM@2|Bacteria,1MZAF@1224|Proteobacteria,2UD6E@28211|Alphaproteobacteria,3JZ2A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5396349_4	1394178.AWOO02000016_gene6843	6.652e-13	74.0	COG3173@1|root,COG3173@2|Bacteria,2GKUU@201174|Actinobacteria,4EFVN@85012|Streptosporangiales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS3_k127_5398402_4	379066.GAU_1065	7.143e-74	274.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZSND@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS3_k127_5398402_0	861299.J421_6095	9.117e-86	301.0	COG0531@1|root,COG0531@2|Bacteria,1ZUQJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
CMS3_k127_5398402_3	1210884.HG799467_gene13438	3.618e-76	264.0	COG1082@1|root,COG1082@2|Bacteria,2IWW9@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase domain protein TIM barrel	-	-	5.1.3.30,5.1.3.31	ko:K18910	-	-	R10817,R10818	RC03111,RC03283	ko00000,ko01000	-	-	-	AP_endonuc_2
CMS3_k127_5398402_5	1340493.JNIF01000003_gene2689	1.022e-33	138.0	COG2020@1|root,COG2020@2|Bacteria,3Y79Z@57723|Acidobacteria	57723|Acidobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CMS3_k127_5398402_7	398580.Dshi_1814	5.557e-07	63.0	COG2931@1|root,COG2931@2|Bacteria,1NV5X@1224|Proteobacteria,2URVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5398402_6	497964.CfE428DRAFT_0242	9.377e-13	80.0	COG1858@1|root,COG3391@1|root,COG3534@1|root,COG5276@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,COG3534@2|Bacteria,COG5276@2|Bacteria,46U43@74201|Verrucomicrobia	74201|Verrucomicrobia	C	SMART LamG domain protein jellyroll fold domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,LVIVD,Laminin_G_3,PKD
CMS3_k127_5398402_1	1198452.Jab_1c13230	6.095e-80	301.0	COG1266@1|root,COG1266@2|Bacteria,1NID0@1224|Proteobacteria	1224|Proteobacteria	S	metal-dependent membrane protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
CMS3_k127_5398402_2	1198452.Jab_1c13240	1.267e-79	273.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VKGA@28216|Betaproteobacteria,477B7@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_5403110_0	344747.PM8797T_25391	1.551e-72	259.0	COG1657@1|root,COG1657@2|Bacteria,2IXQ8@203682|Planctomycetes	203682|Planctomycetes	I	Prenyltransferase and squalene oxidase repeat	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
CMS3_k127_5403110_1	575540.Isop_3540	5.884e-18	99.0	COG1196@1|root,COG1196@2|Bacteria,2J548@203682|Planctomycetes	203682|Planctomycetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5404301_2	289377.HL41_05240	3.042e-34	133.0	COG1158@1|root,COG1158@2|Bacteria,2GGXS@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
CMS3_k127_5404301_0	518766.Rmar_1770	7.102e-89	306.0	COG1131@1|root,COG1131@2|Bacteria,4NEH0@976|Bacteroidetes,1FJR1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	ABC transporter	gldA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_5404301_1	502025.Hoch_5379	1.121e-48	186.0	COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2YVMT@29|Myxococcales	28221|Deltaproteobacteria	N	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
CMS3_k127_5404301_3	1121931.AUHG01000001_gene3103	2.163e-26	126.0	COG3225@1|root,COG3225@2|Bacteria,4NF62@976|Bacteroidetes,1HX9X@117743|Flavobacteriia	976|Bacteroidetes	N	Gliding motility protein GldG	gldG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC_transp_aux
CMS3_k127_5404837_2	648996.Theam_0725	4.016e-24	108.0	COG0568@1|root,COG0568@2|Bacteria,2G3MY@200783|Aquificae	200783|Aquificae	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS3_k127_5404837_0	316274.Haur_4391	1.508e-123	408.0	COG1960@1|root,COG1960@2|Bacteria,2G5K3@200795|Chloroflexi,374SC@32061|Chloroflexia	32061|Chloroflexia	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_5404837_1	748449.Halha_0098	4.689e-98	337.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,3WA7K@53433|Halanaerobiales	186801|Clostridia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
CMS3_k127_5408194_0	1144275.COCOR_06667	2.468e-137	442.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2YUFE@29|Myxococcales	28221|Deltaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
CMS3_k127_5408194_1	1005994.GTGU_03856	0.000133	53.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG0767 ABC-type transport system involved in resistance to organic solvents, permease component	mlaE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
CMS3_k127_5415241_1	886293.Sinac_3370	3.866e-137	440.0	COG3119@1|root,COG3119@2|Bacteria,2IXXZ@203682|Planctomycetes	203682|Planctomycetes	P	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_5415241_4	639030.JHVA01000001_gene2022	3.023e-26	118.0	COG3794@1|root,COG3794@2|Bacteria,3Y4C0@57723|Acidobacteria,2JJME@204432|Acidobacteriia	204432|Acidobacteriia	C	Polysaccharide lyase family 4, domain II	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_5415241_2	497964.CfE428DRAFT_0769	1.366e-115	392.0	COG1520@1|root,COG1520@2|Bacteria,46UNX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_5415241_3	113355.CM001775_gene3965	4.364e-105	353.0	COG1397@1|root,COG1397@2|Bacteria,1G30S@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM ADP-ribosylation Crystallin J1	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
CMS3_k127_5415241_0	756272.Plabr_2497	2.306e-145	472.0	COG3119@1|root,COG3119@2|Bacteria,2IWX1@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
CMS3_k127_5416213_0	379066.GAU_3840	4.017e-40	153.0	COG1595@1|root,COG1595@2|Bacteria,1ZV2F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS3_k127_5416213_4	324602.Caur_1863	0.000321	51.0	COG1306@1|root,COG4932@1|root,COG1306@2|Bacteria,COG4932@2|Bacteria,2G81Y@200795|Chloroflexi,374TT@32061|Chloroflexia	32061|Chloroflexia	M	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF4015
CMS3_k127_5416213_5	33898.JRHJ01000069_gene7385	0.0004975	47.0	COG0477@1|root,COG4932@1|root,COG0477@2|Bacteria,COG4932@2|Bacteria,2GJ09@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,MFS_1
CMS3_k127_5416213_1	234267.Acid_1623	1.957e-37	145.0	COG2801@1|root,COG2801@2|Bacteria,3Y821@57723|Acidobacteria	57723|Acidobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
CMS3_k127_5416213_2	886293.Sinac_7312	3.01e-15	90.0	COG1657@1|root,COG1657@2|Bacteria,2IXVT@203682|Planctomycetes	203682|Planctomycetes	I	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	A2M_comp,DUF4159,Prenyltrans
CMS3_k127_5416213_3	1297742.A176_00134	9.137e-11	76.0	COG3485@1|root,COG3485@2|Bacteria,1QXUR@1224|Proteobacteria,43C7D@68525|delta/epsilon subdivisions,2X7HP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_5423418_0	583355.Caka_2936	9.712e-148	475.0	COG1082@1|root,COG1082@2|Bacteria,46UVB@74201|Verrucomicrobia,3K7PN@414999|Opitutae	414999|Opitutae	G	AP endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
CMS3_k127_5423418_1	1340493.JNIF01000003_gene3276	1.93e-68	248.0	COG0477@1|root,COG2814@2|Bacteria,3Y2T2@57723|Acidobacteria	57723|Acidobacteria	EGP	Nucleoside H+ symporter	-	-	-	-	-	-	-	-	-	-	-	-	Nuc_H_symport
CMS3_k127_5423418_3	1210884.HG799464_gene10441	6.669e-19	91.0	COG0457@1|root,COG0457@2|Bacteria,2J0VV@203682|Planctomycetes	203682|Planctomycetes	S	Iodothyronine deiodinase	-	-	-	-	-	-	-	-	-	-	-	-	T4_deiodinase
CMS3_k127_5423418_4	1210884.HG799464_gene10441	0.0001017	52.0	COG0457@1|root,COG0457@2|Bacteria,2J0VV@203682|Planctomycetes	203682|Planctomycetes	S	Iodothyronine deiodinase	-	-	-	-	-	-	-	-	-	-	-	-	T4_deiodinase
CMS3_k127_5423418_2	428125.CLOLEP_02119	6.874e-23	112.0	COG4409@1|root,COG4409@2|Bacteria,1V5Q1@1239|Firmicutes,24FGZ@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130,Glyco_hydro_32N,Glyco_hydro_43
CMS3_k127_5423418_5	393595.ABO_1727	0.0001065	48.0	COG0457@1|root,COG3271@1|root,COG0457@2|Bacteria,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,1S2EC@1236|Gammaproteobacteria,1XRU4@135619|Oceanospirillales	135619|Oceanospirillales	S	FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2,Peptidase_C70,TPR_16,TPR_8
CMS3_k127_5428048_0	945713.IALB_0020	3.893e-44	163.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	hom	-	1.1.1.3,1.1.1.399,1.1.1.95,1.3.1.12,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04517,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00400,ko00401,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00400,map00401,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00025,M00570	R00220,R00996,R01513,R01728,R01773,R01775	RC00031,RC00087,RC00125,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3
CMS3_k127_5428048_2	1242864.D187_003866	6.18e-06	60.0	COG4932@1|root,COG4932@2|Bacteria,1Q2N2@1224|Proteobacteria,4388V@68525|delta/epsilon subdivisions,2X3IH@28221|Deltaproteobacteria,2YW8A@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,PDZ_2
CMS3_k127_5431216_4	886293.Sinac_4427	4.509e-40	154.0	COG3023@1|root,COG3023@2|Bacteria,2J257@203682|Planctomycetes	203682|Planctomycetes	V	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
CMS3_k127_5431216_2	595460.RRSWK_02981	7.768e-104	346.0	COG2133@1|root,COG2133@2|Bacteria,2J537@203682|Planctomycetes	203682|Planctomycetes	G	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,ThuA
CMS3_k127_5431216_1	644966.Tmar_0705	2.46e-127	458.0	COG2936@1|root,COG2936@2|Bacteria,1TT0H@1239|Firmicutes,24BT1@186801|Clostridia,3WD7J@538999|Clostridiales incertae sedis	186801|Clostridia	S	PFAM X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS3_k127_5431216_3	502025.Hoch_5307	5.439e-78	286.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,42T9X@68525|delta/epsilon subdivisions,2WP59@28221|Deltaproteobacteria,2YWRF@29|Myxococcales	28221|Deltaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS3_k127_5431216_0	1121377.KB906398_gene2691	4.475e-292	932.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
CMS3_k127_5431216_5	1211813.CAPH01000001_gene1158	1.78e-15	78.0	COG0564@1|root,COG0564@2|Bacteria,4NHCT@976|Bacteroidetes,2FNNK@200643|Bacteroidia,22U04@171550|Rikenellaceae	976|Bacteroidetes	J	RNA pseudouridylate synthase	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS3_k127_5434663_1	1246474.ANBE01000011_gene3613	1.37e-28	126.0	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria,4EG08@85012|Streptosporangiales	201174|Actinobacteria	M	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,NACHT,NB-ARC,Pentapeptide,TIR_2,WD40
CMS3_k127_5434663_0	1121374.KB891585_gene2046	9.687e-31	138.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	iSFxv_1172.SFxv_3035	SurE
CMS3_k127_5434663_2	67267.JNXT01000058_gene7634	1.758e-11	77.0	COG5555@1|root,COG5555@2|Bacteria,2GKZ9@201174|Actinobacteria	201174|Actinobacteria	N	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,VCBS
CMS3_k127_5435094_0	1122939.ATUD01000001_gene577	3.446e-183	604.0	COG1520@1|root,COG1520@2|Bacteria,2H3K4@201174|Actinobacteria,4CRJK@84995|Rubrobacteria	84995|Rubrobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5435094_1	1047013.AQSP01000126_gene2751	2.664e-14	83.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_54360_2	247490.KSU1_D0801	4.081e-23	116.0	COG1452@1|root,COG1452@2|Bacteria,2IXFV@203682|Planctomycetes	203682|Planctomycetes	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	OstA_C
CMS3_k127_54360_1	1313265.JNIE01000002_gene686	9.358e-37	149.0	COG1778@1|root,COG1778@2|Bacteria,2G45K@200783|Aquificae	200783|Aquificae	S	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
CMS3_k127_54360_0	290397.Adeh_4064	2.953e-37	144.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,42M0M@68525|delta/epsilon subdivisions,2WJ4Y@28221|Deltaproteobacteria,2YV2A@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_1278	CBS,SIS
CMS3_k127_5439773_2	298654.FraEuI1c_6635	9.36e-10	70.0	COG2319@1|root,COG2909@1|root,COG2319@2|Bacteria,COG2909@2|Bacteria,2GJN3@201174|Actinobacteria,4EUR9@85013|Frankiales	201174|Actinobacteria	P	WD-40 repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4062,NB-ARC,WD40
CMS3_k127_5439773_0	886293.Sinac_6317	1.243e-77	291.0	COG4102@1|root,COG4102@2|Bacteria,2IXXV@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_5439773_1	1396418.BATQ01000184_gene2582	1.099e-49	196.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_2,PSCyt2,PSD1
CMS3_k127_5440005_0	880072.Desac_1827	1.804e-109	386.0	COG2202@1|root,COG2204@1|root,COG3829@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WJSJ@28221|Deltaproteobacteria,2MSID@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
CMS3_k127_5450317_0	1242864.D187_006938	1.285e-56	224.0	COG1474@1|root,COG2319@1|root,COG1474@2|Bacteria,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,42P8D@68525|delta/epsilon subdivisions,2WMH1@28221|Deltaproteobacteria,2Z33N@29|Myxococcales	28221|Deltaproteobacteria	T	SMART serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_35,Pkinase,WD40
CMS3_k127_5459999_0	314230.DSM3645_16225	2.364e-73	256.0	COG0436@1|root,COG0436@2|Bacteria,2IX5E@203682|Planctomycetes	203682|Planctomycetes	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_5459999_3	530564.Psta_1648	8.21e-10	62.0	2DRVG@1|root,33D8Q@2|Bacteria,2J19Z@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5459999_1	404589.Anae109_4471	3.005e-20	107.0	COG0457@1|root,COG0457@2|Bacteria,1RKQQ@1224|Proteobacteria,42T9T@68525|delta/epsilon subdivisions,2WPQ0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_16,TPR_2,TPR_8
CMS3_k127_5459999_2	670487.Ocepr_0847	1.089e-15	85.0	COG1573@1|root,COG1573@2|Bacteria,1WJ72@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS3_k127_5461597_3	474922.ELA24853	2.466e-26	126.0	COG0666@1|root,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3P0CS@4751|Fungi,3QQN4@4890|Ascomycota,218IW@147550|Sordariomycetes,1EYJ4@1028384|Glomerellales	4751|Fungi	M	ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,HeLo,NACHT
CMS3_k127_5461597_1	926550.CLDAP_28000	1.556e-140	459.0	COG0626@1|root,COG0626@2|Bacteria,2G7Q6@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Cys Met metabolism pyridoxal-phosphate-dependent	-	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
CMS3_k127_5461597_4	953739.SVEN_5577	0.0006641	50.0	COG0294@1|root,COG0294@2|Bacteria,2GJDQ@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CMS3_k127_5461597_0	517417.Cpar_1297	1.818e-155	501.0	COG1740@1|root,COG1740@2|Bacteria,1FD8K@1090|Chlorobi	1090|Chlorobi	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
CMS3_k127_5461597_2	1203554.HMPREF1476_01321	4.935e-45	164.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2VJ52@28216|Betaproteobacteria,4PQPN@995019|Sutterellaceae	28216|Betaproteobacteria	C	Nickel-dependent hydrogenase	hoxG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
CMS3_k127_5461920_3	1379698.RBG1_1C00001G1206	3.926e-13	77.0	COG1215@1|root,COG1215@2|Bacteria,2NQN7@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
CMS3_k127_5461920_1	1195246.AGRI_00715	1.795e-119	418.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria,469ZI@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	carbamoyl transferase, NodU family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS3_k127_5461920_2	643562.Daes_0699	1.708e-73	270.0	COG0451@1|root,COG0451@2|Bacteria,1NEDD@1224|Proteobacteria,42QH7@68525|delta/epsilon subdivisions,2WIME@28221|Deltaproteobacteria,2MDGB@213115|Desulfovibrionales	28221|Deltaproteobacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5461920_0	1041930.Mtc_0200	1.06e-120	411.0	COG0367@1|root,COG0449@1|root,arCOG00057@2157|Archaea,arCOG00071@2157|Archaea,2XV5E@28890|Euryarchaeota,2N9BC@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	asnB-1	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS3_k127_5463503_0	555088.DealDRAFT_0321	4.527e-75	263.0	COG0484@1|root,COG0484@2|Bacteria,1TS44@1239|Firmicutes,24A9N@186801|Clostridia,42KC0@68298|Syntrophomonadaceae	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	CbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
CMS3_k127_5465249_2	290397.Adeh_4064	2.384e-63	229.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,42M0M@68525|delta/epsilon subdivisions,2WJ4Y@28221|Deltaproteobacteria,2YV2A@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_1278	CBS,SIS
CMS3_k127_5465249_5	1144275.COCOR_01519	2.929e-06	60.0	COG4932@1|root,COG4932@2|Bacteria,1R5S8@1224|Proteobacteria	1224|Proteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_5465249_4	76114.ebD53	3.094e-07	57.0	COG0822@1|root,COG0822@2|Bacteria,1RDGB@1224|Proteobacteria	1224|Proteobacteria	C	COG0822 NifU homolog involved in Fe-S cluster formation	nifU	-	-	-	-	-	-	-	-	-	-	-	NifU_N
CMS3_k127_5465249_0	883.DvMF_0353	1.151e-111	374.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2M9PA@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
CMS3_k127_5465249_3	338963.Pcar_2245	3.51e-08	66.0	COG0265@1|root,COG0265@2|Bacteria,1RINT@1224|Proteobacteria,42UDP@68525|delta/epsilon subdivisions,2WQQ6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
CMS3_k127_5465249_1	395493.BegalDRAFT_0840	6.712e-79	289.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,4601R@72273|Thiotrichales	72273|Thiotrichales	E	TIGRFAM aminopeptidase N, Escherichia coli type	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
CMS3_k127_5465466_1	398525.KB900701_gene6120	1.053e-51	196.0	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TT9U@28211|Alphaproteobacteria,3JVU8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
CMS3_k127_5465466_0	1089553.Tph_c26440	8.967e-111	377.0	COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,42FUX@68295|Thermoanaerobacterales	186801|Clostridia	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
CMS3_k127_5465466_2	502025.Hoch_0547	8.968e-37	154.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase,TPR_12
CMS3_k127_5468347_0	383372.Rcas_1300	1.566e-06	61.0	COG2373@1|root,COG2373@2|Bacteria,2G5XN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM alpha-2-macroglobulin domain protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1
CMS3_k127_5475242_1	530564.Psta_2041	5.323e-33	146.0	COG1450@1|root,COG3170@1|root,COG1450@2|Bacteria,COG3170@2|Bacteria,2IY62@203682|Planctomycetes	203682|Planctomycetes	NU	Belongs to the GSP D family	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin
CMS3_k127_5475242_0	195522.BD01_0631	4.665e-40	158.0	COG1011@1|root,arCOG02291@2157|Archaea,2XTX3@28890|Euryarchaeota,243KR@183968|Thermococci	183968|Thermococci	S	Catalyzes the dephosphorylation of D,L-glyceraldehyde 3- phosphate in vitro	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CMS3_k127_5478074_0	1123314.AUIO01000003_gene1269	4.036e-50	189.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,4HBBH@91061|Bacilli	91061|Bacilli	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
CMS3_k127_5478074_1	1379698.RBG1_1C00001G0558	3.582e-20	107.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Calx-beta,FG-GAP,VCBS
CMS3_k127_5490369_0	227882.SAV_806	7.523e-121	404.0	COG0457@1|root,COG0457@2|Bacteria,2HX8A@201174|Actinobacteria	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
CMS3_k127_5490369_9	204669.Acid345_1602	6.592e-07	62.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS3_k127_5490369_4	243090.RB6057	6.873e-24	115.0	COG1657@1|root,COG1657@2|Bacteria,2IXVT@203682|Planctomycetes	203682|Planctomycetes	I	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	A2M_comp,DUF4159,Prenyltrans
CMS3_k127_5490369_10	1156935.QWE_20942	1.375e-06	62.0	COG1595@1|root,COG1595@2|Bacteria,1RFN0@1224|Proteobacteria,2U8N2@28211|Alphaproteobacteria,4B6YU@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5490369_1	1380394.JADL01000001_gene2668	1.324e-93	321.0	COG0662@1|root,COG0662@2|Bacteria,1NX8W@1224|Proteobacteria,2TY4P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_5490369_5	497964.CfE428DRAFT_2683	2.887e-18	95.0	COG5426@1|root,COG5426@2|Bacteria,46U69@74201|Verrucomicrobia	74201|Verrucomicrobia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5490369_2	344747.PM8797T_10694	1.671e-43	185.0	COG1657@1|root,COG1657@2|Bacteria,2IYCT@203682|Planctomycetes	203682|Planctomycetes	I	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
CMS3_k127_5490369_8	1118235.CAJH01000046_gene2889	1.695e-08	69.0	COG0823@1|root,COG0823@2|Bacteria,1MZ1T@1224|Proteobacteria,1RMNE@1236|Gammaproteobacteria,1X6J1@135614|Xanthomonadales	135614|Xanthomonadales	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
CMS3_k127_5490369_6	1201290.M902_1137	6.341e-16	83.0	COG0848@1|root,COG0848@2|Bacteria,1NJ5R@1224|Proteobacteria,42XAY@68525|delta/epsilon subdivisions	1224|Proteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
CMS3_k127_5490369_3	754477.Q7C_1288	1.206e-32	137.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,460KS@72273|Thiotrichales	72273|Thiotrichales	U	MotA TolQ ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
CMS3_k127_5490369_7	1235803.C825_03072	2.544e-09	68.0	COG0457@1|root,COG1729@1|root,COG4105@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,COG4105@2|Bacteria,4NE4W@976|Bacteroidetes,2FM3C@200643|Bacteroidia,22X5K@171551|Porphyromonadaceae	976|Bacteroidetes	G	Tetratricopeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
CMS3_k127_54908_0	1121385.AQXW01000003_gene561	1.172e-83	292.0	COG2232@1|root,COG2232@2|Bacteria,2IDDC@201174|Actinobacteria,1ZWHS@145357|Dermacoccaceae	201174|Actinobacteria	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_54908_1	1108045.GORHZ_073_00030	2.918e-72	276.0	COG0457@1|root,COG2885@1|root,COG2931@1|root,COG0457@2|Bacteria,COG2885@2|Bacteria,COG2931@2|Bacteria,2IBAR@201174|Actinobacteria	201174|Actinobacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_54908_2	1117379.BABA_23665	1.218e-45	190.0	COG0584@1|root,COG3540@1|root,COG0584@2|Bacteria,COG3540@2|Bacteria,1UY23@1239|Firmicutes,4HEAD@91061|Bacilli,1ZCIE@1386|Bacillus	91061|Bacilli	C	glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.3.1,3.1.4.46	ko:K01113,ko:K01126	ko00564,ko00790,ko01100,ko02020,map00564,map00790,map01100,map02020	M00126	R01030,R01470,R04620	RC00017,RC00425	ko00000,ko00001,ko00002,ko01000	-	-	-	GDPD
CMS3_k127_5490903_5	448385.sce5487	3.306e-18	99.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1MV1P@1224|Proteobacteria,430N6@68525|delta/epsilon subdivisions,2WVRE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Pkinase
CMS3_k127_5490903_3	251221.35213692	3.703e-38	154.0	COG1091@1|root,COG1091@2|Bacteria,1G3IE@1117|Cyanobacteria	1117|Cyanobacteria	M	dTDP-4-dehydrorhamnose reductase	rmlD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
CMS3_k127_5490903_0	1303518.CCALI_01587	2.075e-145	476.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	dprE1	GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010383,GO:0016020,GO:0016051,GO:0031221,GO:0033692,GO:0034637,GO:0034645,GO:0035884,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0070589,GO:0070592,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901576	1.1.3.8,1.1.98.3	ko:K00103,ko:K16653	ko00053,ko01100,map00053,map01100	M00129	R00647,R03184,R10053	RC00195,RC00346,RC00869	ko00000,ko00001,ko00002,ko01000	-	-	-	ALO,FAD_binding_4
CMS3_k127_5490903_2	1192034.CAP_3530	4.058e-74	258.0	COG0300@1|root,COG0300@2|Bacteria,1NGXF@1224|Proteobacteria,42Q5Q@68525|delta/epsilon subdivisions,2WNMS@28221|Deltaproteobacteria,2YV1C@29|Myxococcales	28221|Deltaproteobacteria	S	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,adh_short
CMS3_k127_5490903_4	331869.BAL199_06841	7.276e-24	114.0	COG1597@1|root,COG1597@2|Bacteria,1RIPU@1224|Proteobacteria,2TVUD@28211|Alphaproteobacteria,4BQTY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
CMS3_k127_5490903_1	891968.Anamo_0324	1.769e-95	320.0	COG2877@1|root,COG2877@2|Bacteria,3T9Z1@508458|Synergistetes	508458|Synergistetes	H	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
CMS3_k127_5501753_1	317936.Nos7107_3248	6.306e-10	71.0	COG3420@1|root,COG3420@2|Bacteria,1G2FG@1117|Cyanobacteria,1HIR5@1161|Nostocales	1117|Cyanobacteria	P	Parallel beta-helix repeat (Two copies)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1565,SLH
CMS3_k127_5501753_0	1122939.ATUD01000001_gene577	2.957e-133	449.0	COG1520@1|root,COG1520@2|Bacteria,2H3K4@201174|Actinobacteria,4CRJK@84995|Rubrobacteria	84995|Rubrobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5502259_1	489825.LYNGBM3L_21180	2.613e-64	227.0	COG0438@1|root,COG0438@2|Bacteria,1GCX5@1117|Cyanobacteria	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5502259_0	489825.LYNGBM3L_21180	5.697e-138	449.0	COG0438@1|root,COG0438@2|Bacteria,1GCX5@1117|Cyanobacteria	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5502259_2	1540257.JQMW01000013_gene1310	8.034e-26	111.0	COG1619@1|root,COG1619@2|Bacteria,1TRBB@1239|Firmicutes,24ABA@186801|Clostridia	186801|Clostridia	V	LD-carboxypeptidase	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
CMS3_k127_5509101_2	485913.Krac_7992	8.627e-45	176.0	COG2936@1|root,COG2936@2|Bacteria,2G85Q@200795|Chloroflexi	200795|Chloroflexi	S	PFAM X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
CMS3_k127_5509101_1	543632.JOJL01000006_gene9758	2.326e-58	214.0	COG0330@1|root,COG0330@2|Bacteria,2HX0N@201174|Actinobacteria,4DKWI@85008|Micromonosporales	201174|Actinobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS3_k127_5509101_0	1396141.BATP01000035_gene4008	5.944e-90	315.0	COG3119@1|root,COG3119@2|Bacteria,46ZIZ@74201|Verrucomicrobia,2IV4W@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_5509101_3	215803.DB30_0358	4.884e-07	64.0	COG0823@1|root,COG1520@1|root,COG3055@1|root,COG0823@2|Bacteria,COG1520@2|Bacteria,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Ig_3,PD40,PKD,Peptidase_S8
CMS3_k127_5522333_0	237368.SCABRO_03177	4.982e-107	353.0	COG2022@1|root,COG2022@2|Bacteria,2IY2Y@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
CMS3_k127_5522333_5	1120948.KB903229_gene5271	2.302e-13	79.0	COG1266@1|root,COG1266@2|Bacteria,2HZR1@201174|Actinobacteria,4EDD8@85010|Pseudonocardiales	2|Bacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
CMS3_k127_5522333_4	1121937.AUHJ01000002_gene3381	1.672e-47	183.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1S3WC@1236|Gammaproteobacteria,466YX@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	yrdA	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
CMS3_k127_5522333_2	215803.DB30_0292	9.664e-70	239.0	COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,42RKY@68525|delta/epsilon subdivisions,2WNSM@28221|Deltaproteobacteria,2YXUH@29|Myxococcales	28221|Deltaproteobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS3_k127_5522333_3	1396141.BATP01000003_gene5168	3.056e-56	220.0	2EKQJ@1|root,33EEC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5522333_1	459495.SPLC1_S371140	8.419e-78	273.0	COG0457@1|root,COG4225@1|root,COG0457@2|Bacteria,COG4225@2|Bacteria,1GIAH@1117|Cyanobacteria,1HFNG@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
CMS3_k127_5547660_0	234267.Acid_4431	2.037e-104	364.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
CMS3_k127_5547660_2	404589.Anae109_2325	1.26e-12	81.0	COG1572@1|root,COG2885@1|root,COG2911@1|root,COG3209@1|root,COG1572@2|Bacteria,COG2885@2|Bacteria,COG2911@2|Bacteria,COG3209@2|Bacteria,1PFUJ@1224|Proteobacteria,430XP@68525|delta/epsilon subdivisions,2WW66@28221|Deltaproteobacteria	2|Bacteria	M	TIGRFAM YD repeat protein	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Calx-beta,DctA-YdbH,RHS_repeat
CMS3_k127_5547660_1	1122939.ATUD01000001_gene577	1.128e-90	325.0	COG1520@1|root,COG1520@2|Bacteria,2H3K4@201174|Actinobacteria,4CRJK@84995|Rubrobacteria	84995|Rubrobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5551383_0	1353529.M899_0208	4.449e-69	261.0	COG2010@1|root,COG2010@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2MUN1@213481|Bdellovibrionales,2WPS4@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Cytochrome c	pcmF	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
CMS3_k127_5559236_3	446466.Cfla_0765	5.642e-43	164.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CMS3_k127_5559236_0	502025.Hoch_1969	5.802e-140	456.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MJD@68525|delta/epsilon subdivisions,2WJC4@28221|Deltaproteobacteria,2YXYZ@29|Myxococcales	28221|Deltaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	epsN	-	2.6.1.102	ko:K13010,ko:K19430	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
CMS3_k127_5559236_4	204669.Acid345_3825	7.055e-38	163.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	-	2.1.1.45,2.7.4.9	ko:K00560,ko:K00943	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02094,R02098,R02101	RC00002,RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
CMS3_k127_5559236_2	204669.Acid345_3824	7.894e-48	186.0	COG0510@1|root,COG0510@2|Bacteria	2|Bacteria	M	ethanolamine kinase activity	strN	-	2.7.1.72,2.7.1.89	ko:K04343,ko:K07251,ko:K18844	ko00730,ko01100,map00730,map01100	M00766	R02134,R02225	RC00002,RC00017,RC00078	br01600,ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	APH,Choline_kinase
CMS3_k127_5559236_1	485918.Cpin_2280	6.202e-59	225.0	COG0438@1|root,COG0438@2|Bacteria,4P0H1@976|Bacteroidetes,1IXVA@117747|Sphingobacteriia	976|Bacteroidetes	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_5559236_5	1229203.KI301992_gene2299	1.618e-21	98.0	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,3UXNU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,Wzz
CMS3_k127_556738_1	1123368.AUIS01000011_gene1139	3.746e-70	257.0	COG1404@1|root,COG1404@2|Bacteria,1R90Q@1224|Proteobacteria,1S01H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
CMS3_k127_556738_0	56780.SYN_02341	2.454e-91	328.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,42UJ1@68525|delta/epsilon subdivisions,2WR2I@28221|Deltaproteobacteria,2MSCR@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,Pentapeptide
CMS3_k127_556795_0	555088.DealDRAFT_1878	1.134e-276	867.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes	1239|Firmicutes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
CMS3_k127_556795_1	28072.Nos7524_1480	9.197e-121	415.0	COG0006@1|root,COG0006@2|Bacteria,1G0KH@1117|Cyanobacteria,1HJU9@1161|Nostocales	1117|Cyanobacteria	E	Belongs to the peptidase M24B family	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
CMS3_k127_556795_4	401526.TcarDRAFT_0553	2.079e-06	57.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,4H2RV@909932|Negativicutes	909932|Negativicutes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
CMS3_k127_556795_2	378806.STAUR_5050	3.932e-105	360.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,42P5X@68525|delta/epsilon subdivisions,2WIQW@28221|Deltaproteobacteria,2YU6V@29|Myxococcales	28221|Deltaproteobacteria	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
CMS3_k127_556795_3	1191523.MROS_1735	4.576e-57	206.0	COG0733@1|root,COG0733@2|Bacteria	2|Bacteria	S	neurotransmitter:sodium symporter activity	CP_0468	-	-	ko:K03308,ko:K03466	-	-	-	-	ko00000,ko03036	2.A.22.4,2.A.22.5,3.A.12	-	-	SNF
CMS3_k127_5572952_0	1347392.CCEZ01000049_gene1349	1.027e-51	197.0	COG3064@1|root,COG3064@2|Bacteria,1VB1V@1239|Firmicutes,24BPB@186801|Clostridia,36IZY@31979|Clostridiaceae	186801|Clostridia	M	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5572952_2	204669.Acid345_1602	7.318e-06	57.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS3_k127_5572952_1	909663.KI867150_gene1265	1.019e-42	165.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria,2MQ7P@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CMS3_k127_5572972_3	329726.AM1_2178	9.01e-08	63.0	COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,1G102@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran,FHA
CMS3_k127_5572972_0	84531.JMTZ01000023_gene4233	2.808e-74	278.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1X499@135614|Xanthomonadales	1236|Gammaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small
CMS3_k127_5572972_1	319795.Dgeo_2151	7.377e-43	165.0	COG0740@1|root,COG0740@2|Bacteria,1WI6Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
CMS3_k127_5572972_2	211586.SO_4418	2.505e-08	67.0	COG3942@1|root,COG3942@2|Bacteria,1RDN2@1224|Proteobacteria,1S3SU@1236|Gammaproteobacteria,2QBCP@267890|Shewanellaceae	1236|Gammaproteobacteria	S	CHAP domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAP
CMS3_k127_5592359_4	1356852.N008_11510	1.471e-05	58.0	COG1572@1|root,COG1572@2|Bacteria,4NWGQ@976|Bacteroidetes,47SIB@768503|Cytophagia	976|Bacteroidetes	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
CMS3_k127_5592359_3	1000588.HMPREF9965_0382	3.256e-18	91.0	COG4859@1|root,COG4859@2|Bacteria	2|Bacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4262
CMS3_k127_5592359_1	926550.CLDAP_33840	3.514e-117	384.0	COG1313@1|root,COG1313@2|Bacteria,2G65I@200795|Chloroflexi	200795|Chloroflexi	C	Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS3_k127_5592359_5	440512.C211_11477	0.0009577	52.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Dehydrogenase	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
CMS3_k127_5592359_0	886293.Sinac_7011	0.0	1317.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG2755@1|root,COG3794@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,COG2755@2|Bacteria,COG3794@2|Bacteria,2IX6X@203682|Planctomycetes	203682|Planctomycetes	C	Membrane-bound dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cytochrom_C,Cytochrome_CBB3,F5_F8_type_C,HEAT_2,Lipase_GDSL_2
CMS3_k127_5592359_2	1242864.D187_003015	2.016e-29	138.0	COG0642@1|root,COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,42Z45@68525|delta/epsilon subdivisions,2WTWB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_4
CMS3_k127_5595788_0	929713.NIASO_10110	2.829e-07	57.0	2AR54@1|root,31GER@2|Bacteria,4NSCR@976|Bacteroidetes,1IT8F@117747|Sphingobacteriia	976|Bacteroidetes	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
CMS3_k127_5595788_1	1131814.JAFO01000001_gene2921	2.133e-06	60.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,3F0F9@335928|Xanthobacteraceae	28211|Alphaproteobacteria	M	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
CMS3_k127_5619019_0	314278.NB231_13646	9.59e-100	347.0	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1MXA1@1224|Proteobacteria,1RQ1F@1236|Gammaproteobacteria,1WX4F@135613|Chromatiales	135613|Chromatiales	P	ABC-type glycine betaine transport system	-	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
CMS3_k127_5619019_1	1500306.JQLA01000032_gene3726	1.951e-80	274.0	COG1125@1|root,COG1125@2|Bacteria,1QTUC@1224|Proteobacteria,2TTMA@28211|Alphaproteobacteria,4BCV7@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	ABC transporter	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran
CMS3_k127_5619019_2	1463825.JNXC01000022_gene560	7.718e-37	158.0	COG4301@1|root,COG4301@2|Bacteria,2GJAX@201174|Actinobacteria,4DYPU@85010|Pseudonocardiales	201174|Actinobacteria	S	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine	egtD	-	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
CMS3_k127_5619019_3	59463.ENSMLUP00000002021	1.608e-23	116.0	COG0500@1|root,KOG1541@2759|Eukaryota,39WWY@33154|Opisthokonta,3BKKG@33208|Metazoa,3D4UF@33213|Bilateria,488HM@7711|Chordata,497F8@7742|Vertebrata,3JC89@40674|Mammalia,4M2SJ@9397|Chiroptera	33208|Metazoa	Q	Williams-Beuren syndrome chromosomal region 27 protein	WBSCR27	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS3_k127_562264_2	62928.azo1883	1.039e-61	224.0	COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2VIZC@28216|Betaproteobacteria,2KUC0@206389|Rhodocyclales	206389|Rhodocyclales	I	phytoene	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
CMS3_k127_562264_3	713587.THITH_09110	1.055e-49	189.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,1RNRI@1236|Gammaproteobacteria,1WYA5@135613|Chromatiales	135613|Chromatiales	I	Squalene phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
CMS3_k127_562264_4	1123368.AUIS01000001_gene2030	4.622e-43	174.0	COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,1SI1R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
CMS3_k127_562264_0	1121930.AQXG01000001_gene1127	1.228e-121	397.0	COG0388@1|root,COG0388@2|Bacteria,4NEME@976|Bacteroidetes,1IPIY@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	pabB	-	3.5.1.53,3.5.1.6	ko:K01431,ko:K12251	ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100	M00046	R00905,R01152,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
CMS3_k127_562264_5	794903.OPIT5_21345	2.375e-06	54.0	2EMGZ@1|root,33F5K@2|Bacteria,46TB4@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_562264_1	1121405.dsmv_3039	1.502e-66	239.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,42N0J@68525|delta/epsilon subdivisions,2WJFX@28221|Deltaproteobacteria,2MHNC@213118|Desulfobacterales	28221|Deltaproteobacteria	J	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
CMS3_k127_5626155_1	1047013.AQSP01000142_gene242	1.925e-33	133.0	COG2511@1|root,COG2511@2|Bacteria	2|Bacteria	J	GatB/GatE catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	GatB_N
CMS3_k127_5626155_0	595460.RRSWK_03836	3.709e-167	538.0	COG3119@1|root,COG3119@2|Bacteria,2IX69@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_5637900_4	243231.GSU0203	5.158e-11	71.0	COG2068@1|root,COG2068@2|Bacteria,1RAAE@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Metal-dependent phosphohydrolase, HD	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	HD,NTP_transf_3
CMS3_k127_5637900_3	1121439.dsat_1703	1.204e-38	151.0	COG0461@1|root,COG0461@2|Bacteria,1PI8N@1224|Proteobacteria,42QSR@68525|delta/epsilon subdivisions,2WMT5@28221|Deltaproteobacteria,2M822@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
CMS3_k127_5637900_1	309807.SRU_1744	7.031e-82	289.0	COG3804@1|root,COG3804@2|Bacteria	2|Bacteria	-	-	ord	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047530,GO:0055114,GO:0071704,GO:1901564,GO:1901605	1.4.1.12,1.4.1.16,1.4.1.26	ko:K03340,ko:K21672	ko00300,ko00310,ko00330,ko00472,ko01100,ko01110,ko01230,map00300,map00310,map00330,map00472,map01100,map01110,map01230	M00526	R02755,R02825,R04200,R04201,R04687,R04688	RC00006,RC00249,RC00790	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N
CMS3_k127_5637900_2	1451189.CFAL_05910	3.819e-43	167.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,22KYD@1653|Corynebacteriaceae	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
CMS3_k127_5637900_0	880073.Calab_3060	8.621e-121	394.0	COG0214@1|root,COG0214@2|Bacteria,2NNZ6@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
CMS3_k127_5638965_3	323261.Noc_2061	9.526e-21	103.0	COG0362@1|root,COG0362@2|Bacteria,1MVV8@1224|Proteobacteria,1RM7P@1236|Gammaproteobacteria,1WXT4@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
CMS3_k127_5638965_2	1380390.JIAT01000009_gene454	5.53e-25	110.0	COG0363@1|root,COG0363@2|Bacteria,2GMQ2@201174|Actinobacteria,4CQA7@84995|Rubrobacteria	84995|Rubrobacteria	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	-	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
CMS3_k127_5638965_0	1210884.HG799464_gene10986	2.814e-141	465.0	COG0364@1|root,COG0364@2|Bacteria,2IXCV@203682|Planctomycetes	203682|Planctomycetes	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
CMS3_k127_5638965_1	1122939.ATUD01000001_gene577	1.023e-124	422.0	COG1520@1|root,COG1520@2|Bacteria,2H3K4@201174|Actinobacteria,4CRJK@84995|Rubrobacteria	84995|Rubrobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5649946_1	1128427.KB904821_gene588	1.449e-89	305.0	COG1252@1|root,COG1252@2|Bacteria,1G20T@1117|Cyanobacteria,1H80B@1150|Oscillatoriales	1117|Cyanobacteria	C	NADH dehydrogenase, FAD-containing subunit	ndbA	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
CMS3_k127_5649946_0	398767.Glov_3511	6.525e-188	605.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM ABC transporter related	uup	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
CMS3_k127_5650442_0	344747.PM8797T_02844	1.642e-216	684.0	COG3420@1|root,COG3420@2|Bacteria,2J2QH@203682|Planctomycetes	203682|Planctomycetes	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS3_k127_5650442_1	744979.R2A130_0970	3.119e-83	306.0	COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,2TTT6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
CMS3_k127_5656770_0	521674.Plim_3913	2.786e-212	670.0	COG3119@1|root,COG3119@2|Bacteria,2IY4T@203682|Planctomycetes	203682|Planctomycetes	P	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
CMS3_k127_5658071_6	344747.PM8797T_01214	1.346e-10	70.0	COG2010@1|root,COG2010@2|Bacteria,2IYHH@203682|Planctomycetes	203682|Planctomycetes	C	PFAM Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1
CMS3_k127_5658071_4	671143.DAMO_0250	1.784e-14	87.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
CMS3_k127_5658071_2	443143.GM18_2583	2.112e-32	136.0	COG4191@1|root,COG4191@2|Bacteria,1MY12@1224|Proteobacteria,42PID@68525|delta/epsilon subdivisions,2WJVW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9
CMS3_k127_5658071_7	1515746.HR45_19110	0.0001796	50.0	COG4319@1|root,COG4319@2|Bacteria,1MZRB@1224|Proteobacteria,1SC2M@1236|Gammaproteobacteria,2QBK7@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
CMS3_k127_5658071_1	575540.Isop_1256	8.159e-47	186.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Ribonuc_L-PSP
CMS3_k127_5658071_5	697303.Thewi_0601	5.042e-14	85.0	COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia,42EZJ@68295|Thermoanaerobacterales	186801|Clostridia	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
CMS3_k127_5658071_0	575540.Isop_1258	4.463e-107	377.0	COG1228@1|root,COG1228@2|Bacteria,2J0GA@203682|Planctomycetes	203682|Planctomycetes	Q	COGs COG1228 Imidazolonepropionase and related amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_5658071_3	203119.Cthe_1777	3.257e-22	113.0	COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia,3WGRH@541000|Ruminococcaceae	186801|Clostridia	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
CMS3_k127_5665531_2	1216007.AOPM01000092_gene966	8.364e-59	215.0	COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,1RYXR@1236|Gammaproteobacteria,2Q1G4@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	enzyme related to lactoylglutathione lyase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
CMS3_k127_5665531_3	1449126.JQKL01000036_gene1950	2.801e-23	112.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind
CMS3_k127_5665531_1	1265310.CCBD010000092_gene4755	2.703e-64	229.0	COG0491@1|root,COG0491@2|Bacteria,2H8JM@201174|Actinobacteria,237CM@1762|Mycobacteriaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_5665531_0	1123242.JH636434_gene4078	5.628e-82	284.0	COG0500@1|root,COG2226@2|Bacteria,2IXEP@203682|Planctomycetes	203682|Planctomycetes	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
CMS3_k127_5665531_4	378806.STAUR_7145	1.726e-10	75.0	COG0793@1|root,COG4932@1|root,COG0793@2|Bacteria,COG4932@2|Bacteria,1Q2N1@1224|Proteobacteria,4388U@68525|delta/epsilon subdivisions,2X3IG@28221|Deltaproteobacteria,2Z0RK@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_5665762_3	1121859.KB890755_gene1122	3.514e-15	76.0	COG0657@1|root,COG0657@2|Bacteria,4NJ8D@976|Bacteroidetes	976|Bacteroidetes	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,DLH,Lipase_GDSL_2,Peptidase_S9
CMS3_k127_5665762_0	298655.KI912267_gene7755	1.926e-153	495.0	COG1373@1|root,COG1373@2|Bacteria,2GK1Q@201174|Actinobacteria	201174|Actinobacteria	J	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS3_k127_5665762_1	314230.DSM3645_11631	8.678e-46	172.0	COG1595@1|root,COG1595@2|Bacteria,2J3FS@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS3_k127_5665762_2	314230.DSM3645_11621	2.122e-15	82.0	COG0515@1|root,COG0515@2|Bacteria,2IY6U@203682|Planctomycetes	203682|Planctomycetes	KLT	COG0515 Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_5666833_1	756272.Plabr_0423	1.689e-49	180.0	COG3119@1|root,COG3119@2|Bacteria,2IXG7@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_5666833_2	118166.JH976537_gene494	4.295e-49	185.0	COG0682@1|root,COG0682@2|Bacteria,1G2EX@1117|Cyanobacteria,1HA7E@1150|Oscillatoriales	1117|Cyanobacteria	M	Prolipoprotein diacylglyceryl transferase	-	-	-	-	-	-	-	-	-	-	-	-	LGT
CMS3_k127_5666833_0	682795.AciX8_1058	3.125e-182	584.0	COG1964@1|root,COG1964@2|Bacteria,3Y79Y@57723|Acidobacteria,2JKYQ@204432|Acidobacteriia	204432|Acidobacteriia	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM
CMS3_k127_5666833_3	1210884.HG799476_gene15399	1.702e-15	91.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS3_k127_5666833_4	1316936.K678_00916	0.0004414	53.0	COG0457@1|root,COG0535@1|root,COG0457@2|Bacteria,COG0535@2|Bacteria,1Q4SE@1224|Proteobacteria,2VB7I@28211|Alphaproteobacteria,2JW46@204441|Rhodospirillales	204441|Rhodospirillales	U	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM,TPR_16,TPR_19
CMS3_k127_5674316_3	215803.DB30_6428	3.342e-17	88.0	2EEXH@1|root,338QV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GT87,PMT_2
CMS3_k127_5674316_1	251221.35214774	1.768e-81	304.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,TIG,VCBS
CMS3_k127_5674316_2	595460.RRSWK_04777	1.665e-42	172.0	COG1595@1|root,COG1595@2|Bacteria,2IZ8A@203682|Planctomycetes	203682|Planctomycetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS3_k127_5674316_0	1396141.BATP01000060_gene4560	6.232e-184	615.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,46UAE@74201|Verrucomicrobia,2IV44@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_12,WD40
CMS3_k127_5674316_4	556269.ACDQ01000011_gene241	1.914e-14	76.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,472IA@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
CMS3_k127_5686776_4	755732.Fluta_0221	1.304e-41	160.0	COG1670@1|root,COG1670@2|Bacteria,4NNKJ@976|Bacteroidetes,1I2F8@117743|Flavobacteriia	976|Bacteroidetes	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_4
CMS3_k127_5686776_0	621372.ACIH01000150_gene3703	9.702e-176	576.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_3,Epimerase
CMS3_k127_5686776_3	1211035.CD30_13635	7.601e-56	213.0	COG1011@1|root,COG1011@2|Bacteria,1TRP5@1239|Firmicutes,4HBSP@91061|Bacilli,3IXXI@400634|Lysinibacillus	91061|Bacilli	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CMS3_k127_5686776_5	1430331.EP10_16705	5.236e-41	168.0	COG1861@1|root,COG1861@2|Bacteria,1U4YD@1239|Firmicutes,4HE69@91061|Bacilli	91061|Bacilli	M	Acylneuraminate cytidylyltransferase	spsF	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3
CMS3_k127_5686776_1	32024.JMTI01000035_gene885	8.121e-83	289.0	COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,42ME3@68525|delta/epsilon subdivisions,2YMDZ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	acid synthase	pseI	-	2.5.1.56,2.5.1.97	ko:K01654,ko:K15898	ko00520,ko01100,map00520,map01100	-	R01804,R04435,R09841	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
CMS3_k127_5686776_2	502025.Hoch_0336	4.99e-64	222.0	COG0491@1|root,COG0491@2|Bacteria,1R4FA@1224|Proteobacteria,42TJ6@68525|delta/epsilon subdivisions,2WR3Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_5688497_0	690850.Desaf_2575	3.383e-25	119.0	COG2067@1|root,COG2067@2|Bacteria,1RDE4@1224|Proteobacteria,42Y3S@68525|delta/epsilon subdivisions,2WY29@28221|Deltaproteobacteria,2MAMJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5702952_3	1469607.KK073768_gene3237	1.027e-15	91.0	COG2267@1|root,COG2267@2|Bacteria,1G38C@1117|Cyanobacteria,1HK9B@1161|Nostocales	1117|Cyanobacteria	I	Alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
CMS3_k127_5702952_1	502025.Hoch_4451	1.424e-34	148.0	COG0477@1|root,COG2814@2|Bacteria,1R518@1224|Proteobacteria,43B4F@68525|delta/epsilon subdivisions,2WIQ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_5702952_0	1499967.BAYZ01000193_gene3921	1.736e-77	269.0	COG0382@1|root,COG0382@2|Bacteria,2NNVJ@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	ubiA	-	-	-	-	-	-	-	-	-	-	-	UbiA
CMS3_k127_5708957_0	1121874.KB892379_gene363	1.87e-14	83.0	COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,3VNUE@526524|Erysipelotrichia	526524|Erysipelotrichia	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
CMS3_k127_5721134_0	525909.Afer_0742	1.032e-34	153.0	COG0438@1|root,COG0438@2|Bacteria,2GIVP@201174|Actinobacteria,4CN35@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_5721134_2	1122223.KB890700_gene2026	1.47e-18	98.0	COG0438@1|root,COG0438@2|Bacteria,1WK9I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_5721134_1	298655.KI912266_gene172	6.489e-19	102.0	COG0438@1|root,COG0438@2|Bacteria,2GIVP@201174|Actinobacteria,4ERHJ@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_5729513_6	1463821.JOGR01000012_gene4197	1.913e-06	57.0	COG0507@1|root,COG0507@2|Bacteria,2GJRK@201174|Actinobacteria,4EZJ5@85014|Glycomycetales	201174|Actinobacteria	L	Helix-hairpin-helix containing domain	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
CMS3_k127_5729513_0	344747.PM8797T_25491	4.61e-156	509.0	COG3653@1|root,COG3653@2|Bacteria,2IXWQ@203682|Planctomycetes	203682|Planctomycetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS3_k127_5729513_7	457570.Nther_1191	1.312e-05	54.0	COG0828@1|root,COG0828@2|Bacteria,1VEHU@1239|Firmicutes,24QP9@186801|Clostridia	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
CMS3_k127_5729513_1	575540.Isop_1438	1.554e-58	216.0	COG0564@1|root,COG0564@2|Bacteria,2IXSI@203682|Planctomycetes	203682|Planctomycetes	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS3_k127_5729513_5	1461580.CCAS010000003_gene455	1.338e-07	64.0	28HMX@1|root,2Z7WB@2|Bacteria,1TPJG@1239|Firmicutes,4HBRI@91061|Bacilli,1ZCDH@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5729513_3	404589.Anae109_1820	5.147e-20	95.0	COG2456@1|root,COG2456@2|Bacteria,1NF5Z@1224|Proteobacteria,42VNI@68525|delta/epsilon subdivisions,2WS2M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Uncharacterized conserved protein (DUF2304)	-	-	-	ko:K09153	-	-	-	-	ko00000	-	-	-	DUF2304
CMS3_k127_5729513_2	290397.Adeh_3051	4.774e-53	202.0	COG1216@1|root,COG1216@2|Bacteria,1QW1K@1224|Proteobacteria,43BRI@68525|delta/epsilon subdivisions,2WN0V@28221|Deltaproteobacteria,2Z30Y@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_5729513_4	237368.SCABRO_03725	4.907e-18	84.0	COG1697@1|root,COG1697@2|Bacteria,2J34C@203682|Planctomycetes	203682|Planctomycetes	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
CMS3_k127_5729570_0	644282.Deba_3126	4.378e-224	707.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
CMS3_k127_5729570_1	1168034.FH5T_00235	1.936e-41	158.0	COG0176@1|root,COG0176@2|Bacteria,4P1X0@976|Bacteroidetes,2FX3H@200643|Bacteroidia	976|Bacteroidetes	G	Transaldolase/Fructose-6-phosphate aldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
CMS3_k127_5733748_3	671143.DAMO_2125	4.54e-21	100.0	COG0724@1|root,COG0724@2|Bacteria,2NPT0@2323|unclassified Bacteria	2|Bacteria	S	RNA recognition motif	rbpD	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS3_k127_5733748_4	521000.PROVRETT_05381	2.389e-14	84.0	2EH6J@1|root,33AYF@2|Bacteria,1NJ4C@1224|Proteobacteria,1ST5Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5733748_5	264462.Bd0289	7.289e-07	60.0	2DR0H@1|root,339NS@2|Bacteria,1Q21V@1224|Proteobacteria,437PH@68525|delta/epsilon subdivisions,2MUAK@213481|Bdellovibrionales,2X2XV@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
CMS3_k127_5733748_1	518766.Rmar_0231	2.855e-69	243.0	COG1845@1|root,COG1845@2|Bacteria,4NDYG@976|Bacteroidetes,1FJ6D@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Cytochrome c oxidase subunit III	coxP	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
CMS3_k127_5733748_0	234267.Acid_0498	4.307e-269	839.0	COG0843@1|root,COG0843@2|Bacteria,3Y2X6@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
CMS3_k127_5733748_2	204669.Acid345_2996	1.802e-35	138.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,3Y2GR@57723|Acidobacteria,2JHRF@204432|Acidobacteriia	204432|Acidobacteriia	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
CMS3_k127_5737902_0	886293.Sinac_5359	6.857e-157	509.0	COG1158@1|root,COG1158@2|Bacteria,2IXV3@203682|Planctomycetes	203682|Planctomycetes	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
CMS3_k127_5737902_1	1196323.ALKF01000192_gene3221	6.685e-36	143.0	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,4HII3@91061|Bacilli,26WY5@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08510	CoaE
CMS3_k127_5738771_0	234267.Acid_5449	2.844e-52	194.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_5746374_0	945713.IALB_1083	4.47e-54	208.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,CarboxypepD_reg,LVIVD,TSP_3
CMS3_k127_5746374_1	314271.RB2654_06724	6.898e-29	135.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2
CMS3_k127_5748828_1	886293.Sinac_5601	5.761e-111	365.0	COG2010@1|root,COG2010@2|Bacteria,2J53S@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
CMS3_k127_5748828_0	886293.Sinac_5600	2.575e-209	663.0	COG4102@1|root,COG4102@2|Bacteria,2IX5T@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_5749735_1	1379698.RBG1_1C00001G0513	3.248e-41	156.0	COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
CMS3_k127_5749735_0	1210884.HG799462_gene7892	2.444e-66	235.0	COG1082@1|root,COG1082@2|Bacteria,2IYC6@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS3_k127_5760352_2	234267.Acid_2266	6.994e-167	561.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,WD40
CMS3_k127_5760352_0	234267.Acid_2265	3.613e-189	603.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_5760352_1	234267.Acid_2264	1.276e-184	590.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_2,PSCyt2,PSD1
CMS3_k127_5760352_3	1122939.ATUD01000001_gene577	1.707e-144	490.0	COG1520@1|root,COG1520@2|Bacteria,2H3K4@201174|Actinobacteria,4CRJK@84995|Rubrobacteria	84995|Rubrobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_577319_1	1123366.TH3_12640	3.758e-70	246.0	COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,2U1XJ@28211|Alphaproteobacteria,2JSCX@204441|Rhodospirillales	204441|Rhodospirillales	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,DLH
CMS3_k127_577319_0	1122604.JONR01000068_gene4226	1.009e-97	328.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,1RNCX@1236|Gammaproteobacteria,1X3TJ@135614|Xanthomonadales	135614|Xanthomonadales	G	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
CMS3_k127_577319_2	760192.Halhy_5603	1.329e-22	113.0	COG5276@1|root,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes	976|Bacteroidetes	E	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3
CMS3_k127_577319_3	1452718.JBOY01000190_gene845	2.349e-14	87.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5790214_2	1123399.AQVE01000011_gene1258	0.0006402	52.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,1N4WT@1224|Proteobacteria	1224|Proteobacteria	UW	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
CMS3_k127_5790214_0	118168.MC7420_245	4.814e-53	203.0	COG1073@1|root,COG1073@2|Bacteria,1GCE9@1117|Cyanobacteria,1HE33@1150|Oscillatoriales	1117|Cyanobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS3_k127_5790214_1	1123242.JH636436_gene23	9.35e-24	107.0	COG1335@1|root,COG1413@1|root,COG2010@1|root,COG2133@1|root,COG3828@1|root,COG1335@2|Bacteria,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,COG3828@2|Bacteria,2IX4V@203682|Planctomycetes	203682|Planctomycetes	C	COG2133 Glucose sorbosone dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
CMS3_k127_579036_0	518766.Rmar_1795	7.519e-127	415.0	COG0379@1|root,COG0379@2|Bacteria,4NDVX@976|Bacteroidetes,1FJC0@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
CMS3_k127_579036_1	215803.DB30_6945	4.999e-98	344.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42QVZ@68525|delta/epsilon subdivisions,2WMVN@28221|Deltaproteobacteria,2YUQR@29|Myxococcales	28221|Deltaproteobacteria	S	Vault protein inter-alpha-trypsin domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
CMS3_k127_5810320_0	1267533.KB906733_gene3472	5.343e-71	270.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,TPR_8
CMS3_k127_5810320_2	521674.Plim_0986	6.602e-22	108.0	COG1595@1|root,COG1595@2|Bacteria,2IZ9U@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
CMS3_k127_5810320_1	1185876.BN8_02230	2.294e-56	214.0	COG4977@1|root,COG4977@2|Bacteria,4NHHE@976|Bacteroidetes,47RDA@768503|Cytophagia	976|Bacteroidetes	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
CMS3_k127_5811293_9	1121377.KB906406_gene162	0.0001408	55.0	COG2374@1|root,COG4085@1|root,COG2374@2|Bacteria,COG4085@2|Bacteria	2|Bacteria	S	PFAM nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Big_3_5,Big_5,Endonuclease_1,LTD
CMS3_k127_5811293_7	391009.Tmel_1008	4.471e-05	57.0	COG2374@1|root,COG4085@1|root,COG2374@2|Bacteria,COG4085@2|Bacteria,2GCXZ@200918|Thermotogae	200918|Thermotogae	S	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
CMS3_k127_5811293_5	1457250.BBMO01000001_gene1978	1.887e-06	59.0	COG3595@1|root,arCOG03825@2157|Archaea,2XWNU@28890|Euryarchaeota,23V5V@183963|Halobacteria	183963|Halobacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS3_k127_5811293_8	1303518.CCALI_02307	5.068e-05	55.0	COG4232@1|root,COG4232@2|Bacteria	2|Bacteria	CO	protein-disulfide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6,Thioredoxin_7
CMS3_k127_5811293_6	204669.Acid345_1602	2.572e-06	58.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS3_k127_5811293_1	518766.Rmar_1973	5.246e-109	359.0	COG1878@1|root,COG1878@2|Bacteria,4PIWM@976|Bacteroidetes,1FJPB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Putative cyclase	-	GO:0003674,GO:0003824,GO:0004061,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
CMS3_k127_5811293_2	1379698.RBG1_1C00001G1745	8.44e-66	233.0	COG1100@1|root,COG1100@2|Bacteria,2NPDD@2323|unclassified Bacteria	2|Bacteria	K	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	mglA	GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,DUF697,MMR_HSR1
CMS3_k127_5811293_0	313628.LNTAR_22434	1.7e-172	565.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_5811293_4	1396141.BATP01000060_gene4599	8.499e-32	144.0	COG0657@1|root,COG0657@2|Bacteria,46XJ2@74201|Verrucomicrobia,2IW1U@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5811293_3	864051.BurJ1DRAFT_3859	1.63e-34	151.0	2C6BE@1|root,32XBJ@2|Bacteria,1NB89@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5812451_0	583355.Caka_2440	3.664e-132	446.0	COG0514@1|root,COG0514@2|Bacteria,46S7V@74201|Verrucomicrobia,3K7AV@414999|Opitutae	414999|Opitutae	L	ATP-dependent DNA helicase RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
CMS3_k127_5812451_1	439235.Dalk_3087	7.47e-20	95.0	COG1763@1|root,COG1763@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	-	ko:K03753,ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	-
CMS3_k127_5820257_2	682795.AciX8_3590	0.000752	48.0	COG3391@1|root,COG3391@2|Bacteria,3Y52X@57723|Acidobacteria,2JJDZ@204432|Acidobacteriia	204432|Acidobacteriia	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5820257_0	1379281.AVAG01000029_gene31	1.442e-30	136.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42S15@68525|delta/epsilon subdivisions,2WNI1@28221|Deltaproteobacteria,2MBH5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
CMS3_k127_5820257_1	1122164.JHWF01000019_gene482	0.00025	45.0	COG3437@1|root,COG3437@2|Bacteria,1QXI4@1224|Proteobacteria	1224|Proteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS3_k127_5820905_3	661478.OP10G_2046	3.79e-58	223.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS3_k127_5820905_0	661478.OP10G_2046	5.218e-83	304.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS3_k127_5820905_2	384765.SIAM614_06238	6.42e-69	236.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2U7C4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
CMS3_k127_5820905_4	1123388.AQWU01000071_gene48	9.605e-15	85.0	COG0775@1|root,COG0775@2|Bacteria,1WIHW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnB	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	3.2.2.26	ko:K11783	ko00130,ko01110,map00130,map01110	-	R08587	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
CMS3_k127_5820905_1	595460.RRSWK_06700	5.641e-74	267.0	COG2107@1|root,COG2107@2|Bacteria,2IXIY@203682|Planctomycetes	203682|Planctomycetes	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
CMS3_k127_5824796_2	548479.HMPREF0573_11797	3.101e-56	209.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4D3IX@85005|Actinomycetales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS3_k127_5824796_0	595460.RRSWK_05871	2.763e-168	542.0	COG3828@1|root,COG3828@2|Bacteria,2IX0E@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,ThuA
CMS3_k127_5824796_1	1396418.BATQ01000056_gene160	9.204e-83	291.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS3_k127_5826072_2	485916.Dtox_4108	4.681e-06	57.0	COG3944@1|root,COG3944@2|Bacteria,1UZCR@1239|Firmicutes,24HS8@186801|Clostridia,262KP@186807|Peptococcaceae	186801|Clostridia	M	PFAM Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
CMS3_k127_5826072_1	1238182.C882_1591	1.629e-53	206.0	COG3307@1|root,COG3307@2|Bacteria,1PX0E@1224|Proteobacteria,2TT7I@28211|Alphaproteobacteria,2JRHJ@204441|Rhodospirillales	204441|Rhodospirillales	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
CMS3_k127_5826072_0	1089552.KI911559_gene3686	2.324e-145	481.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JQXF@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0367 Asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS3_k127_5830877_0	243231.GSU2085	7.702e-95	320.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,43TN4@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_0922	CTP_transf_like,PfkB
CMS3_k127_5830877_3	909663.KI867150_gene798	4.011e-39	151.0	COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,42SGQ@68525|delta/epsilon subdivisions,2WPTP@28221|Deltaproteobacteria,2MQJ3@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	rfaE	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
CMS3_k127_5830877_5	1120958.AULD01000005_gene2276	2.663e-24	113.0	COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,4FMK5@85023|Microbacteriaceae	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS3_k127_5830877_7	264732.Moth_2150	5.414e-07	61.0	COG2203@1|root,COG3437@1|root,COG4936@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG4936@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia,42JGC@68295|Thermoanaerobacterales	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,PAS_9,PocR,SBP_bac_3
CMS3_k127_5830877_4	1142394.PSMK_22270	5.075e-25	119.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,LTD,PPC
CMS3_k127_5830877_1	398767.Glov_3474	6.464e-62	223.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,42QTI@68525|delta/epsilon subdivisions,2WMRH@28221|Deltaproteobacteria,43SYN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.3	ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
CMS3_k127_5830877_6	2045.KR76_18440	1.42e-10	68.0	COG0776@1|root,COG0776@2|Bacteria,2GV0M@201174|Actinobacteria,4DR53@85009|Propionibacteriales	201174|Actinobacteria	L	Belongs to the bacterial histone-like protein family	hup	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006355,GO:0006725,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010106,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019725,GO:0030003,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0040007,GO:0042262,GO:0042592,GO:0042594,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046916,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0060255,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090143,GO:0090304,GO:0097100,GO:0097159,GO:0098771,GO:0140110,GO:1901360,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS3_k127_5830877_2	1121428.DESHY_60354___1	1.835e-53	198.0	COG0455@1|root,COG0455@2|Bacteria,1TRZ5@1239|Firmicutes,24AIN@186801|Clostridia,26151@186807|Peptococcaceae	186801|Clostridia	D	Belongs to the ParA family	flhG	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
CMS3_k127_5830877_8	589865.DaAHT2_0748	5.096e-06	55.0	COG5000@1|root,COG5000@2|Bacteria,1RHDM@1224|Proteobacteria,42SJK@68525|delta/epsilon subdivisions,2WPKX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	phosphorelay sensor kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5834061_5	756272.Plabr_3125	1.192e-12	78.0	COG0845@1|root,COG0845@2|Bacteria,2IY6J@203682|Planctomycetes	203682|Planctomycetes	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS3_k127_5834061_4	502025.Hoch_2845	4.554e-25	109.0	COG0640@1|root,COG0640@2|Bacteria,1PG5K@1224|Proteobacteria,43A8H@68525|delta/epsilon subdivisions,2X9YQ@28221|Deltaproteobacteria,2Z2Q8@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
CMS3_k127_5834061_2	926562.Oweho_2122	5.694e-42	173.0	COG3258@1|root,COG3258@2|Bacteria,4PPAF@976|Bacteroidetes,1IKH8@117743|Flavobacteriia	976|Bacteroidetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5834061_0	102129.Lepto7375DRAFT_1136	7.539e-182	593.0	28IH4@1|root,2Z8IE@2|Bacteria,1G5H6@1117|Cyanobacteria,1HG4U@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5834061_1	102129.Lepto7375DRAFT_1137	1.328e-82	297.0	COG0644@1|root,COG0644@2|Bacteria,1G678@1117|Cyanobacteria,1HDUU@1150|Oscillatoriales	1117|Cyanobacteria	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
CMS3_k127_5834061_3	316067.Geob_0069	1.356e-32	138.0	28JHJ@1|root,2Z9B3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5835475_1	1232437.KL662004_gene4524	1.652e-08	56.0	2EKQJ@1|root,33EEC@2|Bacteria,1Q6FB@1224|Proteobacteria,4331H@68525|delta/epsilon subdivisions,2WXFD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5835475_0	768710.DesyoDRAFT_1775	1.216e-124	424.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	B12-binding,Radical_SAM
CMS3_k127_5838473_4	530564.Psta_2595	4.959e-59	218.0	COG0704@1|root,COG0704@2|Bacteria,2IYX4@203682|Planctomycetes	203682|Planctomycetes	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
CMS3_k127_5838473_0	926569.ANT_27750	2.484e-109	361.0	COG1117@1|root,COG1117@2|Bacteria,2G646@200795|Chloroflexi	200795|Chloroflexi	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
CMS3_k127_5838473_1	926550.CLDAP_00820	7.015e-103	342.0	COG0581@1|root,COG0581@2|Bacteria,2G6BI@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
CMS3_k127_5838473_2	1196323.ALKF01000192_gene3214	1.361e-102	344.0	COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,4HC9H@91061|Bacilli,26SNZ@186822|Paenibacillaceae	91061|Bacilli	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
CMS3_k127_5838473_3	555079.Toce_0354	4.642e-82	278.0	COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia,42EPR@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM extracellular solute-binding protein family 1	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	Big_5,PBP_like_2
CMS3_k127_5838629_0	1123320.KB889739_gene5817	9.819e-49	185.0	COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria	201174|Actinobacteria	IQ	Peptidase S15	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS3_k127_5838629_1	1267535.KB906767_gene581	1.522e-27	131.0	COG2936@1|root,COG2936@2|Bacteria	2|Bacteria	V	dipeptidyl-peptidase activity	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS3_k127_5838629_2	1144275.COCOR_01429	6.747e-15	89.0	COG4932@1|root,COG4932@2|Bacteria,1NXIX@1224|Proteobacteria,430KM@68525|delta/epsilon subdivisions,2WVSB@28221|Deltaproteobacteria,2YYGY@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_5839658_0	926550.CLDAP_15490	1.896e-154	493.0	COG0451@1|root,COG0451@2|Bacteria,2G64F@200795|Chloroflexi	200795|Chloroflexi	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
CMS3_k127_5839658_1	379066.GAU_0583	1.616e-145	472.0	COG0677@1|root,COG0677@2|Bacteria,1ZT42@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	UDP binding domain	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS3_k127_5839658_2	1232410.KI421415_gene3062	1.214e-90	308.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,42MWH@68525|delta/epsilon subdivisions,2WJMZ@28221|Deltaproteobacteria,43U74@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Polysaccharide biosynthesis protein	uge	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS3_k127_5839768_3	1198114.AciX9_1550	5.662e-31	136.0	COG4191@1|root,COG4191@2|Bacteria,3Y9CI@57723|Acidobacteria,2JIFJ@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS3_k127_5839768_0	267608.RSp1667	6.6e-144	486.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1K375@119060|Burkholderiaceae	28216|Betaproteobacteria	T	response regulator	zraR	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_5839768_2	1288494.EBAPG3_13080	5.036e-41	167.0	COG5637@1|root,COG5637@2|Bacteria,1RCEX@1224|Proteobacteria,2VQP4@28216|Betaproteobacteria,3730R@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
CMS3_k127_5839768_1	247490.KSU1_C1034	1.816e-66	239.0	COG3861@1|root,COG3861@2|Bacteria,2IZRE@203682|Planctomycetes	203682|Planctomycetes	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	PRC
CMS3_k127_5839768_4	234267.Acid_7860	0.000611	46.0	COG1595@1|root,COG1595@2|Bacteria,3Y4FY@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_5854367_0	717605.Theco_2421	2.054e-318	996.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,4HAG1@91061|Bacilli,26QCH@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
CMS3_k127_5854367_5	521674.Plim_1137	4.156e-11	71.0	2E3B2@1|root,32YAK@2|Bacteria,2J19J@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
CMS3_k127_5854367_8	383372.Rcas_1195	2.013e-08	63.0	COG1366@1|root,COG2172@1|root,COG1366@2|Bacteria,COG2172@2|Bacteria,2G93H@200795|Chloroflexi,375J3@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	2.7.11.1	ko:K04749,ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2,STAS
CMS3_k127_5854367_1	1168065.DOK_13169	2.576e-191	607.0	COG3185@1|root,COG3185@2|Bacteria,1MVR0@1224|Proteobacteria,1RR9Q@1236|Gammaproteobacteria,1J7M1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Pfam:DUF1446	atuA	-	-	-	-	-	-	-	-	-	-	-	AtuA
CMS3_k127_5854367_2	448385.sce5308	2.946e-136	454.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2YU9C@29|Myxococcales	28221|Deltaproteobacteria	L	DbpA RNA binding domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
CMS3_k127_5854367_9	62928.azo0278	4.866e-08	66.0	2EFNF@1|root,339EK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5854367_7	1336235.JAEG01000014_gene4202	1.594e-09	70.0	COG4927@1|root,COG4927@2|Bacteria,1NKHP@1224|Proteobacteria,2U18B@28211|Alphaproteobacteria,4BE17@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
CMS3_k127_5854367_3	502025.Hoch_1711	2.027e-79	295.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria	1224|Proteobacteria	M	PFAM Formylglycine-generating sulfatase enzyme	-	-	2.7.11.1	ko:K11912,ko:K20333	ko02024,ko02025,ko03070,map02024,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase,PEGA,Pkinase,TIR_2
CMS3_k127_5854367_4	1123508.JH636447_gene7881	1.053e-76	288.0	COG0515@1|root,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_8,WD40
CMS3_k127_5854367_6	543632.JOJL01000011_gene6905	1.304e-09	69.0	COG1595@1|root,COG1595@2|Bacteria,2HGII@201174|Actinobacteria,4DDNQ@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5854584_1	243090.RB4815	7.818e-48	175.0	COG3119@1|root,COG3119@2|Bacteria,2IX69@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.8	ko:K01134	ko00600,ko04142,map00600,map04142	-	R04856	RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS3_k127_5854584_0	756272.Plabr_3935	7.22e-232	727.0	COG3119@1|root,COG3119@2|Bacteria,2J1TM@203682|Planctomycetes	203682|Planctomycetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_5856886_1	1142394.PSMK_20710	1.115e-52	192.0	COG0587@1|root,COG0587@2|Bacteria,2IWSE@203682|Planctomycetes	203682|Planctomycetes	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
CMS3_k127_5856886_0	1192034.CAP_8277	1.866e-73	268.0	COG3266@1|root,COG3266@2|Bacteria,1QZBM@1224|Proteobacteria,42TG7@68525|delta/epsilon subdivisions,2WQPM@28221|Deltaproteobacteria,2Z3I2@29|Myxococcales	28221|Deltaproteobacteria	S	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP_2
CMS3_k127_5856886_3	1123248.KB893323_gene1598	6.768e-05	57.0	COG4625@1|root,COG5295@1|root,COG4625@2|Bacteria,COG5295@2|Bacteria,4NF6Q@976|Bacteroidetes,1IQG8@117747|Sphingobacteriia	976|Bacteroidetes	UW	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_3,M60-like_N,NosD,Peptidase_M60
CMS3_k127_5856886_2	1123242.JH636435_gene1356	6.359e-14	76.0	COG0587@1|root,COG0587@2|Bacteria,2IWSE@203682|Planctomycetes	203682|Planctomycetes	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
CMS3_k127_5859957_1	83406.HDN1F_26870	1.24e-37	145.0	COG1462@1|root,COG1462@2|Bacteria,1NDU8@1224|Proteobacteria,1RPPY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Curli production assembly transport component CsgG	csgG	-	-	-	-	-	-	-	-	-	-	-	CsgG
CMS3_k127_5859957_2	1116375.VEJY3_23041	5.334e-09	67.0	COG4259@1|root,COG4259@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4810)	Z012_10670	-	-	-	-	-	-	-	-	-	-	-	DUF4810
CMS3_k127_5859957_0	857087.Metme_0024	2.194e-39	160.0	COG4380@1|root,COG4380@2|Bacteria,1R3WM@1224|Proteobacteria,1RSP7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	(Lipo)protein	VY92_06375	-	-	-	-	-	-	-	-	-	-	-	DUF799
CMS3_k127_5859957_3	696747.NIES39_C05180	6.755e-06	55.0	COG1520@1|root,COG2931@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,1GQUQ@1117|Cyanobacteria,1HBB3@1150|Oscillatoriales	1117|Cyanobacteria	G	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind
CMS3_k127_5867723_1	1144275.COCOR_05839	1.86e-05	52.0	2DS2B@1|root,33E7G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5867723_0	1278073.MYSTI_04884	1.235e-05	58.0	COG3485@1|root,COG3485@2|Bacteria,1QXUR@1224|Proteobacteria,43C7D@68525|delta/epsilon subdivisions,2X7HP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_5873425_0	1288963.ADIS_4385	5.882e-191	602.0	COG1063@1|root,COG1063@2|Bacteria,4NIU2@976|Bacteroidetes,47MH0@768503|Cytophagia	976|Bacteroidetes	E	Alcohol dehydrogenase GroES-like domain	-	-	1.2.1.46	ko:K00148	ko00625,ko00680,ko01100,ko01120,ko01200,map00625,map00680,map01100,map01120,map01200	-	R00604	RC00188	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_5873425_1	521674.Plim_2004	2.971e-41	166.0	COG1657@1|root,COG1657@2|Bacteria,2J2FU@203682|Planctomycetes	203682|Planctomycetes	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5873425_2	530564.Psta_2703	0.0001242	52.0	COG1657@1|root,COG1657@2|Bacteria,2J41J@203682|Planctomycetes	203682|Planctomycetes	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5876389_4	290397.Adeh_0678	1.391e-09	71.0	COG4972@1|root,COG4972@2|Bacteria,1MYIB@1224|Proteobacteria,42SIX@68525|delta/epsilon subdivisions,2WP1G@28221|Deltaproteobacteria,2YVKD@29|Myxococcales	28221|Deltaproteobacteria	NU	Type IV pilus assembly protein PilM;	gspL	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspL_C,PilM_2,PilN,T2SSL
CMS3_k127_5876389_6	1179778.PMM47T1_25568	9.515e-05	50.0	COG3678@1|root,COG3678@2|Bacteria,1RBDH@1224|Proteobacteria,1S2DT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NPTU	P pilus assembly Cpx signaling pathway, periplasmic inhibitor zinc-resistance associated protein	spy	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0009987,GO:0010033,GO:0014070,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0050896,GO:0051082,GO:0061077,GO:1990507	-	ko:K06006	-	-	-	-	ko00000,ko03110	-	-	-	LTXXQ
CMS3_k127_5876389_2	1112217.PPL19_18215	7.422e-38	153.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0006970,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5876389_0	398767.Glov_0881	4.883e-152	492.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
CMS3_k127_5876389_3	1198232.CYCME_2382	1.376e-29	121.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,460ZB@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the glutaredoxin family. Monothiol subfamily	grxD	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
CMS3_k127_5876389_5	1308866.J416_11687	4.047e-08	66.0	COG0265@1|root,COG0265@2|Bacteria,1UZ3Q@1239|Firmicutes,4HDIX@91061|Bacilli,46ZNY@74385|Gracilibacillus	91061|Bacilli	O	Trypsin-like peptidase domain	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Trypsin_2
CMS3_k127_5876389_1	242159.ABO98982	4.338e-47	179.0	COG0800@1|root,2QVAJ@2759|Eukaryota,37RSU@33090|Viridiplantae	33090|Viridiplantae	G	khg kdpg	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase,RraA-like
CMS3_k127_5890756_0	1123269.NX02_17645	6.339e-08	61.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,2K2V2@204457|Sphingomonadales	204457|Sphingomonadales	S	PFAM Sel1 domain protein repeat-containing protein	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
CMS3_k127_5895780_6	530564.Psta_1625	1.432e-17	95.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K02674,ko:K07114	-	-	-	-	ko00000,ko02000,ko02035,ko02044	1.A.13.2.2,1.A.13.2.3	-	-	CHU_C,Lipase_GDSL_2,Neisseria_PilC,VWA,VWA_2,VWA_3
CMS3_k127_5895780_4	1349785.BAUG01000025_gene1553	1.143e-38	158.0	COG0526@1|root,COG0526@2|Bacteria,4NMKD@976|Bacteroidetes,1I2NA@117743|Flavobacteriia	976|Bacteroidetes	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
CMS3_k127_5895780_1	195250.CM001776_gene1952	1.808e-145	474.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_5895780_0	1232437.KL662020_gene658	1.253e-146	485.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2WJ9N@28221|Deltaproteobacteria,2MHX8@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,TrkA_C,Voltage_CLC
CMS3_k127_5895780_5	1128421.JAGA01000002_gene656	4.086e-20	93.0	COG3695@1|root,COG3695@2|Bacteria,2NRVD@2323|unclassified Bacteria	2|Bacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ogt	-	2.1.1.63	ko:K00567,ko:K07443	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,YjbR
CMS3_k127_5895780_2	335543.Sfum_1623	1.078e-68	258.0	COG3118@1|root,COG3118@2|Bacteria,1PQ8G@1224|Proteobacteria	1224|Proteobacteria	O	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
CMS3_k127_5895780_3	344747.PM8797T_16735	2.069e-59	236.0	COG0501@1|root,COG0501@2|Bacteria,2IXM0@203682|Planctomycetes	203682|Planctomycetes	O	Zn-dependent protease with chaperone function	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CMS3_k127_5895780_7	797210.Halxa_4224	3.682e-06	60.0	COG0281@1|root,arCOG01331@2157|Archaea,2XW19@28890|Euryarchaeota,23RYV@183963|Halobacteria	183963|Halobacteria	O	COG0501 Zn-dependent protease with chaperone function	htpX3	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
CMS3_k127_5912251_2	1313421.JHBV01000052_gene182	2.232e-26	123.0	28HHD@1|root,2Z7T3@2|Bacteria,4NGWB@976|Bacteroidetes,1ISCP@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF3810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3810
CMS3_k127_5912251_1	448385.sce0867	3.55e-96	323.0	COG1099@1|root,COG1099@2|Bacteria,1MY2H@1224|Proteobacteria,43B30@68525|delta/epsilon subdivisions,2X6GS@28221|Deltaproteobacteria,2Z3B0@29|Myxococcales	28221|Deltaproteobacteria	S	TatD related DNase	-	-	-	ko:K07051	-	-	-	-	ko00000	-	-	-	TatD_DNase
CMS3_k127_5912251_3	761193.Runsl_5373	2.949e-23	111.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5912251_4	1123279.ATUS01000001_gene2435	1.081e-05	57.0	COG3173@1|root,COG3173@2|Bacteria,1MY0Y@1224|Proteobacteria,1S3A0@1236|Gammaproteobacteria,1JA5F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS3_k127_5912251_0	1441930.Z042_15245	4.775e-181	588.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,4014W@613|Serratia	1236|Gammaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
CMS3_k127_5912628_2	886293.Sinac_2845	1.661e-22	102.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	Prenyltrans
CMS3_k127_5912628_1	886293.Sinac_5380	5.57e-75	277.0	28PTH@1|root,2ZCER@2|Bacteria,2IZHG@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5912628_0	886293.Sinac_5379	3.113e-93	317.0	28K3C@1|root,2Z9SH@2|Bacteria,2IXIK@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5918073_0	1437448.AZRT01000008_gene4768	1.837e-28	134.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria,1J3JW@118882|Brucellaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_5920900_3	357804.Ping_1917	1.603e-40	151.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,1S9DN@1236|Gammaproteobacteria,2QI9W@267894|Psychromonadaceae	1236|Gammaproteobacteria	O	PPIC-type PPIASE domain	ppiC	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3
CMS3_k127_5920900_2	886293.Sinac_4159	8.766e-47	175.0	COG1881@1|root,COG1881@2|Bacteria,2J1MM@203682|Planctomycetes	203682|Planctomycetes	G	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP,YHYH
CMS3_k127_5920900_0	313628.LNTAR_07564	4.298e-128	436.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS3_k127_5920900_1	251221.35214774	3.238e-47	183.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,TIG,VCBS
CMS3_k127_5922029_8	366602.Caul_1563	0.0003688	44.0	COG1652@1|root,COG1652@2|Bacteria,1RK4N@1224|Proteobacteria	1224|Proteobacteria	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5922029_1	1121405.dsmv_1279	4.042e-119	402.0	COG3501@1|root,COG3501@2|Bacteria,1Q96K@1224|Proteobacteria,42RTE@68525|delta/epsilon subdivisions,2WNJ9@28221|Deltaproteobacteria,2MMJ0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Phage late control gene D protein (GPD)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD,Phage_base_V
CMS3_k127_5922029_5	338963.Pcar_2891	5.429e-35	139.0	2E7P5@1|root,3324R@2|Bacteria,1NEZR@1224|Proteobacteria,42VXG@68525|delta/epsilon subdivisions,2WRNQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5922029_7	1121405.dsmv_1281	8.335e-31	133.0	COG3628@1|root,COG3628@2|Bacteria,1NCAC@1224|Proteobacteria,42TW2@68525|delta/epsilon subdivisions,2WQR5@28221|Deltaproteobacteria,2MNY2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Gene 25-like lysozyme	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
CMS3_k127_5922029_0	1121405.dsmv_1282	4.342e-200	656.0	COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,42QGQ@68525|delta/epsilon subdivisions,2WIVM@28221|Deltaproteobacteria,2MMI8@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
CMS3_k127_5922029_6	338963.Pcar_2888	1.76e-34	148.0	COG4385@1|root,COG4385@2|Bacteria,1N0CW@1224|Proteobacteria,42UPU@68525|delta/epsilon subdivisions,2WR0W@28221|Deltaproteobacteria,43VNS@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Phage tail protein (Tail_P2_I)	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
CMS3_k127_5922029_4	323259.Mhun_0970	4.863e-38	165.0	COG3291@1|root,arCOG02516@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02516@2157|Archaea,2XUY6@28890|Euryarchaeota,2NAFS@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PKD
CMS3_k127_5922029_2	269797.Mbar_A0809	8.121e-49	198.0	COG3291@1|root,arCOG02516@1|root,arCOG02510@2157|Archaea,arCOG02516@2157|Archaea,arCOG05189@2157|Archaea,2Y30D@28890|Euryarchaeota,2NAGI@224756|Methanomicrobia	224756|Methanomicrobia	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	NosD,PKD
CMS3_k127_5922029_3	1121405.dsmv_1286	1.092e-46	176.0	2CHE3@1|root,31B2D@2|Bacteria,1RM3N@1224|Proteobacteria,42TDP@68525|delta/epsilon subdivisions,2WPWY@28221|Deltaproteobacteria,2MNMG@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5923460_0	156889.Mmc1_2198	1.708e-69	255.0	COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2U0H8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Peptidase, M50 family	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	Biotin_lipoyl_2
CMS3_k127_5923460_1	1392838.AWNM01000074_gene441	2.766e-43	179.0	COG0845@1|root,COG0845@2|Bacteria,1N97Q@1224|Proteobacteria,2VH3J@28216|Betaproteobacteria,3T6NQ@506|Alcaligenaceae	28216|Betaproteobacteria	M	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,GAF,HlyD_3
CMS3_k127_5923460_2	864051.BurJ1DRAFT_3036	2.003e-14	84.0	COG0845@1|root,COG0845@2|Bacteria,1RC4B@1224|Proteobacteria,2VSG3@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
CMS3_k127_5943441_0	521096.Tpau_3229	2.975e-24	116.0	COG3012@1|root,COG3012@2|Bacteria,2GMVI@201174|Actinobacteria	201174|Actinobacteria	S	PFAM plasmid pRiA4b ORF-3 family protein	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
CMS3_k127_5943441_1	1196028.ALEF01000016_gene2650	0.000297	54.0	COG1846@1|root,COG3012@1|root,COG1846@2|Bacteria,COG3012@2|Bacteria,1UK0V@1239|Firmicutes,4HFB5@91061|Bacilli	91061|Bacilli	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
CMS3_k127_595006_2	35754.JNYJ01000033_gene2586	2.242e-06	55.0	COG1309@1|root,COG1309@2|Bacteria,2GIVD@201174|Actinobacteria,4DDRP@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_595006_0	309807.SRU_2448	1.218e-131	436.0	COG1228@1|root,COG1228@2|Bacteria,4P0JM@976|Bacteroidetes	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_595006_1	344747.PM8797T_06527	3.997e-88	307.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,2IXGT@203682|Planctomycetes	203682|Planctomycetes	C	heme-binding domain, Pirellula Verrucomicrobium type	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,DUF1080
CMS3_k127_5963443_0	118166.JH976537_gene2633	3.702e-209	666.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1G4JM@1117|Cyanobacteria,1HACJ@1150|Oscillatoriales	1117|Cyanobacteria	P	COG0475 Kef-type K transport systems, membrane components	-	-	-	ko:K11745	-	-	-	-	ko00000,ko02000	2.A.37.1.1	-	-	Na_H_Exchanger,TrkA_N
CMS3_k127_5963443_2	251221.35211906	3.638e-67	234.0	COG2249@1|root,COG2249@2|Bacteria,1G57U@1117|Cyanobacteria	1117|Cyanobacteria	S	Flavodoxin-like fold	-	-	-	ko:K03923,ko:K11748	-	-	-	-	ko00000,ko02000	2.A.37.1.2	-	-	Flavodoxin_2
CMS3_k127_5963443_1	1313301.AUGC01000001_gene1488	1.161e-182	587.0	COG0442@1|root,COG0442@2|Bacteria,4NEAF@976|Bacteroidetes	976|Bacteroidetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
CMS3_k127_5963443_3	1185652.USDA257_c37210	1.173e-57	210.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_5963443_4	388413.ALPR1_05140	8.035e-20	95.0	COG1235@1|root,COG1235@2|Bacteria,4NM16@976|Bacteroidetes,47U32@768503|Cytophagia	976|Bacteroidetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CMS3_k127_5963990_0	240016.ABIZ01000001_gene5287	1.283e-84	293.0	COG3622@1|root,COG3622@2|Bacteria,46TIJ@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS3_k127_5963990_1	497964.CfE428DRAFT_6180	4.191e-54	199.0	COG1520@1|root,COG1520@2|Bacteria,46THI@74201|Verrucomicrobia	2|Bacteria	S	SMART Pyrrolo-quinoline quinone	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
CMS3_k127_5972764_1	936455.KI421499_gene6955	8.252e-138	454.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,3JR6K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Biotin carboxylase C-terminal domain	MA20_22950	-	6.4.1.5	ko:K13777	ko00281,map00281	-	R03494	RC00367,RC00942	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
CMS3_k127_5972764_2	316274.Haur_0853	2.937e-60	228.0	COG1024@1|root,COG1024@2|Bacteria,2G7Z4@200795|Chloroflexi,375KM@32061|Chloroflexia	32061|Chloroflexia	I	PFAM Enoyl-CoA hydratase isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_5972764_0	1123354.AUDR01000011_gene1425	3.377e-240	753.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria	28216|Betaproteobacteria	I	carboxylase	accB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
CMS3_k127_5972764_3	861299.J421_0243	5.356e-05	57.0	COG1413@1|root,COG4219@1|root,COG1413@2|Bacteria,COG4219@2|Bacteria,1ZUUA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,Peptidase_M56
CMS3_k127_5975575_0	857087.Metme_4161	2.322e-43	182.0	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,1RPP5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC transporter substrate-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
CMS3_k127_5975575_1	1121106.JQKB01000049_gene3069	6.414e-40	171.0	COG3848@1|root,COG3848@2|Bacteria,1R7DS@1224|Proteobacteria,2U3SK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Pyruvate phosphate dikinase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_597628_0	1499967.BAYZ01000123_gene2552	1.841e-27	128.0	COG2208@1|root,COG2208@2|Bacteria,2NP51@2323|unclassified Bacteria	2|Bacteria	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HATPase_c_2,SpoIIE,sCache_3_2
CMS3_k127_597628_2	439235.Dalk_2947	1.688e-20	98.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,42U6G@68525|delta/epsilon subdivisions,2WQDR@28221|Deltaproteobacteria,2MKIR@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0195	PgpA
CMS3_k127_597628_1	243090.RB10878	1.75e-24	107.0	COG0558@1|root,COG0558@2|Bacteria,2IZQ1@203682|Planctomycetes	203682|Planctomycetes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS3_k127_5984738_0	756272.Plabr_2226	1.561e-15	82.0	COG1657@1|root,COG1657@2|Bacteria,2IYCT@203682|Planctomycetes	203682|Planctomycetes	I	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
CMS3_k127_6010803_1	765912.Thimo_3175	7.743e-22	103.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1WWU7@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
CMS3_k127_6010803_0	330214.NIDE1937	0.0	1090.0	COG0209@1|root,COG0209@2|Bacteria,3J0MG@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
CMS3_k127_6014194_1	344747.PM8797T_20678	1.59e-105	348.0	COG4102@1|root,COG4102@2|Bacteria,2IYDS@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_6014194_2	1122137.AQXF01000005_gene1008	1.581e-21	105.0	COG2931@1|root,COG2931@2|Bacteria,1NNT4@1224|Proteobacteria,2UKB7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS3_k127_6014194_3	1122137.AQXF01000005_gene1008	5.482e-09	62.0	COG2931@1|root,COG2931@2|Bacteria,1NNT4@1224|Proteobacteria,2UKB7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS3_k127_6014194_0	1129794.C427_1223	6.096e-156	520.0	COG2706@1|root,COG3391@1|root,COG3637@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,COG3637@2|Bacteria,1QWRQ@1224|Proteobacteria,1T4S3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6016011_0	661478.OP10G_2783	1e-93	332.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,PD40,Peptidase_S9
CMS3_k127_6016011_1	1123242.JH636434_gene5302	1.512e-23	103.0	COG1520@1|root,COG1520@2|Bacteria,2IYRB@203682|Planctomycetes	1123242.JH636434_gene5302|-	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6016011_2	497964.CfE428DRAFT_6180	1.032e-06	53.0	COG1520@1|root,COG1520@2|Bacteria,46THI@74201|Verrucomicrobia	2|Bacteria	S	SMART Pyrrolo-quinoline quinone	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
CMS3_k127_6022158_0	493475.GARC_4265	1.143e-44	180.0	COG2931@1|root,COG2982@1|root,COG4733@1|root,COG2931@2|Bacteria,COG2982@2|Bacteria,COG4733@2|Bacteria,1MU7T@1224|Proteobacteria,1S1HJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,DUF4214,DUF4347,He_PIG,HemolysinCabind,PATR,VCBS
CMS3_k127_6022158_2	1192034.CAP_1525	3.112e-12	75.0	COG1595@1|root,COG1595@2|Bacteria,1PD3E@1224|Proteobacteria,43E55@68525|delta/epsilon subdivisions,2X98H@28221|Deltaproteobacteria,2Z2M0@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6022158_1	314271.RB2654_06724	1.459e-26	119.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2
CMS3_k127_6025161_4	1449126.JQKL01000036_gene1950	6.507e-30	136.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind
CMS3_k127_6025161_7	3067.XP_002955717.1	1.036e-07	64.0	2CBEU@1|root,2S84R@2759|Eukaryota,37XAV@33090|Viridiplantae,34IKM@3041|Chlorophyta	3041|Chlorophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6025161_5	886293.Sinac_1102	6.952e-10	70.0	COG0526@1|root,COG0526@2|Bacteria,2J07Q@203682|Planctomycetes	203682|Planctomycetes	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_6025161_3	886293.Sinac_1102	5.008e-35	136.0	COG0526@1|root,COG0526@2|Bacteria,2J07Q@203682|Planctomycetes	203682|Planctomycetes	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_6025161_2	760117.JN27_10625	8.851e-58	219.0	COG2234@1|root,COG2234@2|Bacteria,1RM41@1224|Proteobacteria	1224|Proteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS3_k127_6025161_1	1089550.ATTH01000001_gene1367	6.253e-62	226.0	COG0697@1|root,COG0697@2|Bacteria,4NDYH@976|Bacteroidetes,1FK0X@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EG	EamA-like transporter family	sam	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
CMS3_k127_6025161_0	575540.Isop_2690	2.398e-125	421.0	COG4242@1|root,COG4242@2|Bacteria,2IWZJ@203682|Planctomycetes	203682|Planctomycetes	PQ	Belongs to the peptidase S51 family	-	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
CMS3_k127_6025161_6	1316936.K678_02458	1.058e-08	68.0	COG0457@1|root,COG4976@1|root,COG0457@2|Bacteria,COG4976@2|Bacteria,1RAIT@1224|Proteobacteria,2U5NY@28211|Alphaproteobacteria,2JS93@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,TPR_16,TPR_2,TPR_8
CMS3_k127_6025268_0	1267005.KB911255_gene2872	6.998e-245	773.0	COG0500@1|root,COG1181@1|root,COG1181@2|Bacteria,COG2226@2|Bacteria,1N4F5@1224|Proteobacteria,2U4DQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
CMS3_k127_6025268_1	1123242.JH636434_gene4425	9.301e-78	268.0	COG1028@1|root,COG1028@2|Bacteria,2IYKS@203682|Planctomycetes	203682|Planctomycetes	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_6029147_0	1144319.PMI16_02580	8.098e-25	121.0	COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2VJ7P@28216|Betaproteobacteria,4760X@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
CMS3_k127_6029147_2	345341.KUTG_05920	5.825e-05	53.0	COG1595@1|root,COG1595@2|Bacteria,2GM8T@201174|Actinobacteria,4DY2F@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigD	GO:0000988,GO:0000990,GO:0002791,GO:0003674,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032879,GO:0032880,GO:0043254,GO:0044087,GO:0044419,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051223,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070201,GO:0080090,GO:0090087,GO:0140110,GO:1903506,GO:1903530,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_6029147_1	981369.JQMJ01000004_gene4695	2.421e-07	59.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,2NGSD@228398|Streptacidiphilus	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,SBP_bac_3
CMS3_k127_6029316_0	768671.ThimaDRAFT_1304	0.0	1183.0	COG0210@1|root,COG0514@1|root,COG0847@1|root,COG0210@2|Bacteria,COG0514@2|Bacteria,COG0847@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1WX8Y@135613|Chromatiales	135613|Chromatiales	L	DNA helicase	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,UvrD-helicase,UvrD_C
CMS3_k127_6034140_3	1244869.H261_14190	1.234e-73	250.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,2JQP4@204441|Rhodospirillales	204441|Rhodospirillales	EQ	Hydantoinase B/oxoprolinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydantoinase_B
CMS3_k127_6034140_2	1244869.H261_12221	6.801e-126	413.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,2JPPM@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_6034140_6	1244869.H261_14180	6.316e-37	157.0	COG2185@1|root,COG2185@2|Bacteria,1N56M@1224|Proteobacteria,2UEAN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG2185 Methylmalonyl-CoA mutase, C-terminal domain subunit (cobalamin-binding)	-	-	5.4.99.2,5.4.99.64	ko:K01849,ko:K20907	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
CMS3_k127_6034140_0	1244869.H261_12211	6.831e-221	696.0	COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,2JP9C@204441|Rhodospirillales	204441|Rhodospirillales	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	-	-	-	-	-	-	-	-	-	-	ArgK,B12-binding,MM_CoA_mutase
CMS3_k127_6034140_1	76114.ebA2066	4.695e-132	435.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,2KXPJ@206389|Rhodocyclales	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_6034140_4	935840.JAEQ01000019_gene2104	1.582e-57	213.0	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,2TU08@28211|Alphaproteobacteria,43PT0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	xdhB	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
CMS3_k127_6034140_5	1125863.JAFN01000001_gene1570	5.856e-45	175.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,42S8R@68525|delta/epsilon subdivisions,2WNW6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CMS3_k127_6034140_7	1125863.JAFN01000001_gene1218	2.492e-33	139.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS3_k127_6036608_3	595460.RRSWK_02676	5.782e-33	131.0	COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,2IYH1@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,Cytochrom_C,Cytochrome_CBB3,Laminin_G_3,ThuA
CMS3_k127_6036608_0	886293.Sinac_5576	1.815e-87	297.0	COG0761@1|root,COG0761@2|Bacteria,2IXK4@203682|Planctomycetes	203682|Planctomycetes	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB,UbiA
CMS3_k127_6036608_2	886293.Sinac_5577	1.964e-39	152.0	COG1846@1|root,COG1846@2|Bacteria,2J085@203682|Planctomycetes	203682|Planctomycetes	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
CMS3_k127_6036608_1	575540.Isop_1004	4.717e-45	171.0	2BACU@1|root,323T9@2|Bacteria,2J05N@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6040617_0	595460.RRSWK_06264	1.694e-119	390.0	COG1073@1|root,COG1073@2|Bacteria,2IXPY@203682|Planctomycetes	203682|Planctomycetes	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2,Peptidase_S9
CMS3_k127_6040617_1	521674.Plim_3158	2.03e-51	198.0	COG2208@1|root,COG2208@2|Bacteria,2IYKI@203682|Planctomycetes	203682|Planctomycetes	KT	PFAM Stage II sporulation protein E (SpoIIE)	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
CMS3_k127_6042026_5	498848.TaqDRAFT_5348	2.402e-32	138.0	COG0402@1|root,COG0402@2|Bacteria,1WIN1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	COGs COG0402 Cytosine deaminase and related metal-dependent hydrolase	-	-	3.5.4.40	ko:K20810	ko00130,ko01110,map00130,map01110	-	R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
CMS3_k127_6042026_4	886293.Sinac_6677	4.819e-50	198.0	COG0618@1|root,COG0618@2|Bacteria,2IYQ0@203682|Planctomycetes	203682|Planctomycetes	S	phosphoesterase RecJ domain protein	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
CMS3_k127_6042026_3	521674.Plim_1711	4.651e-60	216.0	COG0639@1|root,COG0639@2|Bacteria,2IYH6@203682|Planctomycetes	203682|Planctomycetes	T	COG0639 Diadenosine tetraphosphatase and related	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
CMS3_k127_6042026_7	500637.PROVRUST_05311	1.288e-12	78.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,1SCFM@1236|Gammaproteobacteria,3Z9B1@586|Providencia	1236|Gammaproteobacteria	P	protein involved in tolerance to divalent cations	cutA	GO:0003674,GO:0005488,GO:0005507,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0016043,GO:0022607,GO:0042221,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046688,GO:0046872,GO:0046914,GO:0050896,GO:0051259,GO:0051260,GO:0065003,GO:0071840	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
CMS3_k127_6042026_6	671143.DAMO_1456	4.728e-21	108.0	COG1807@1|root,COG1807@2|Bacteria,2NRDV@2323|unclassified Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_6042026_2	404589.Anae109_0210	3.129e-68	244.0	COG1215@1|root,COG1215@2|Bacteria,1R988@1224|Proteobacteria,42QKI@68525|delta/epsilon subdivisions,2WM6J@28221|Deltaproteobacteria,2Z2XX@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_6042026_0	1122222.AXWR01000056_gene1579	7.66e-109	371.0	COG0606@1|root,COG0606@2|Bacteria,1WI18@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	ATPase with chaperone activity	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
CMS3_k127_6042026_1	314230.DSM3645_08196	1.382e-87	317.0	COG0457@1|root,COG1729@1|root,COG2373@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,COG2373@2|Bacteria,2IWRT@203682|Planctomycetes	203682|Planctomycetes	S	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,TPR_16
CMS3_k127_6044309_0	1045858.Bint_2272	6.294e-190	617.0	COG0058@1|root,COG0058@2|Bacteria,2J5KC@203691|Spirochaetes	203691|Spirochaetes	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	malP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
CMS3_k127_6044309_1	305700.B447_20126	1.898e-50	190.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VQI1@28216|Betaproteobacteria,2KXTQ@206389|Rhodocyclales	206389|Rhodocyclales	T	COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
CMS3_k127_6057940_2	1278073.MYSTI_00128	0.0008285	47.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,Cna_B
CMS3_k127_6057940_0	765911.Thivi_1885	1.499e-75	259.0	COG1765@1|root,COG1765@2|Bacteria,1MWPR@1224|Proteobacteria,1S7W4@1236|Gammaproteobacteria,1WZVN@135613|Chromatiales	135613|Chromatiales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
CMS3_k127_6057940_1	396588.Tgr7_2569	4.607e-12	66.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1WWQ4@135613|Chromatiales	135613|Chromatiales	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat
CMS3_k127_6059151_0	595460.RRSWK_02676	2.6e-271	866.0	COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,2IYH1@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,Cytochrom_C,Cytochrome_CBB3,Laminin_G_3,ThuA
CMS3_k127_6059151_1	1485543.JMME01000005_gene1025	3.158e-06	60.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H26P@909932|Negativicutes	909932|Negativicutes	NT	Methyl-accepting chemotaxis protein signaling domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
CMS3_k127_6074241_0	1278073.MYSTI_03939	0.0005735	53.0	COG0793@1|root,COG4932@1|root,COG0793@2|Bacteria,COG4932@2|Bacteria,1Q2N3@1224|Proteobacteria,4388W@68525|delta/epsilon subdivisions,2XA2N@28221|Deltaproteobacteria,2YXAB@29|Myxococcales	28221|Deltaproteobacteria	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,PDZ_2
CMS3_k127_6093252_0	314230.DSM3645_06324	3.563e-111	367.0	COG1520@1|root,COG1520@2|Bacteria,2IWVC@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_6093373_0	1125863.JAFN01000001_gene3206	1.436e-80	286.0	COG2159@1|root,COG2159@2|Bacteria,1QZ3W@1224|Proteobacteria,42PKB@68525|delta/epsilon subdivisions,2WM59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
CMS3_k127_6093373_1	384676.PSEEN2513	2.192e-05	53.0	2EIZX@1|root,33CR2@2|Bacteria,1R3NS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6095115_1	290397.Adeh_2888	2.283e-30	128.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6095115_0	875328.JDM601_3150	1.719e-40	155.0	2C945@1|root,32W5M@2|Bacteria,2I86M@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	5.4.4.1	ko:K01865	ko00627,ko01120,map00627,map01120	-	-	-	ko00000,ko00001,ko01000	-	-	-	-
CMS3_k127_6100334_2	234267.Acid_1987	2.472e-63	229.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	bioC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044464	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
CMS3_k127_6100334_3	489825.LYNGBM3L_21110	9.492e-13	79.0	COG1215@1|root,COG1215@2|Bacteria,1GQTA@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_6100334_1	237368.SCABRO_01734	7.008e-109	363.0	COG3754@1|root,COG3754@2|Bacteria	2|Bacteria	M	Rhamnan synthesis protein F	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_WbsX,RgpF
CMS3_k127_6100334_0	1396418.BATQ01000136_gene3672	2.516e-263	835.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
CMS3_k127_6100334_4	1210884.HG799465_gene11731	2.602e-06	49.0	COG1393@1|root,COG1393@2|Bacteria,2J19I@203682|Planctomycetes	203682|Planctomycetes	P	Belongs to the ArsC family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6102223_1	648996.Theam_1304	0.0002279	49.0	COG1432@1|root,COG1432@2|Bacteria,2G42X@200783|Aquificae	200783|Aquificae	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
CMS3_k127_6102223_2	3075.A0A087SKI4	0.0002629	52.0	COG5126@1|root,KOG0027@2759|Eukaryota	2759|Eukaryota	DTZ	Calcium-binding protein	-	-	-	ko:K02183	ko04014,ko04015,ko04016,ko04020,ko04022,ko04024,ko04070,ko04114,ko04218,ko04261,ko04270,ko04371,ko04626,ko04713,ko04720,ko04722,ko04728,ko04740,ko04744,ko04745,ko04750,ko04910,ko04912,ko04915,ko04916,ko04921,ko04922,ko04924,ko04925,ko04970,ko04971,ko05010,ko05031,ko05034,ko05133,ko05152,ko05167,ko05200,ko05214,ko05418,map04014,map04015,map04016,map04020,map04022,map04024,map04070,map04114,map04218,map04261,map04270,map04371,map04626,map04713,map04720,map04722,map04728,map04740,map04744,map04745,map04750,map04910,map04912,map04915,map04916,map04921,map04922,map04924,map04925,map04970,map04971,map05010,map05031,map05034,map05133,map05152,map05167,map05200,map05214,map05418	-	-	-	ko00000,ko00001,ko01009,ko03036,ko04131,ko04147	-	-	-	EF-hand_1,EF-hand_5,EF-hand_7
CMS3_k127_6102223_0	118168.MC7420_6957	6.518e-114	375.0	COG0471@1|root,COG0471@2|Bacteria,1G5AP@1117|Cyanobacteria,1HCDN@1150|Oscillatoriales	1117|Cyanobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
CMS3_k127_6102466_1	1379698.RBG1_1C00001G0779	3.004e-53	205.0	COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
CMS3_k127_6102466_0	671143.DAMO_0826	7.104e-97	338.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	ko:K02569,ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT,Cytochrome_C7
CMS3_k127_6102466_2	945713.IALB_0474	1.514e-10	64.0	COG1734@1|root,COG1734@2|Bacteria	2|Bacteria	T	zinc ion binding	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
CMS3_k127_6107753_2	1123242.JH636435_gene2908	6.237e-35	145.0	COG2319@1|root,COG2319@2|Bacteria,2IZGW@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1549)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt2,PSD1
CMS3_k127_6107753_0	1396141.BATP01000007_gene5658	2.775e-146	475.0	COG4102@1|root,COG4102@2|Bacteria,46U0B@74201|Verrucomicrobia,2IU14@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_6107753_1	1403819.BATR01000191_gene6479	2.036e-52	206.0	COG4886@1|root,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,Fn3_assoc,PSCyt1
CMS3_k127_6107753_3	331869.BAL199_04774	1.4e-29	135.0	2DRHZ@1|root,33BUJ@2|Bacteria,1NC03@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6107753_4	436229.JOEH01000014_gene6129	6.664e-26	124.0	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria,2NEAZ@228398|Streptacidiphilus	201174|Actinobacteria	T	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	WD40
CMS3_k127_6108585_1	886293.Sinac_6719	1.953e-74	276.0	COG5267@1|root,COG5267@2|Bacteria,2IY6E@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
CMS3_k127_6108585_0	886293.Sinac_6720	6.82e-86	299.0	COG4102@1|root,COG4102@2|Bacteria,2IXUC@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_6111297_5	243231.GSU2530	3.096e-34	134.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,42MQV@68525|delta/epsilon subdivisions,2WIZC@28221|Deltaproteobacteria,43S0U@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
CMS3_k127_6111297_8	56780.SYN_01756	5.983e-06	58.0	COG4726@1|root,COG4726@2|Bacteria,1NK1B@1224|Proteobacteria	1224|Proteobacteria	NU	Pilus assembly protein PilX	-	-	-	ko:K02673	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilX_N
CMS3_k127_6111297_0	575540.Isop_3370	2.152e-171	558.0	COG3386@1|root,COG3386@2|Bacteria,2J2MK@203682|Planctomycetes	203682|Planctomycetes	G	BNR repeat-containing family member	-	-	-	-	-	-	-	-	-	-	-	-	BNR_4
CMS3_k127_6111297_6	326427.Cagg_1434	2.319e-25	109.0	COG0239@1|root,COG0239@2|Bacteria,2G760@200795|Chloroflexi,377FT@32061|Chloroflexia	32061|Chloroflexia	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
CMS3_k127_6111297_2	1279009.ADICEAN_01038	7.72e-58	211.0	2BXI0@1|root,2Z9A2@2|Bacteria,4NFDQ@976|Bacteroidetes,47QAC@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF2459)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2459
CMS3_k127_6111297_7	502025.Hoch_5179	4.514e-09	68.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42P0G@68525|delta/epsilon subdivisions,2WK7Y@28221|Deltaproteobacteria,2YVQ5@29|Myxococcales	28221|Deltaproteobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
CMS3_k127_6111297_1	926550.CLDAP_37850	1.795e-108	363.0	COG0665@1|root,COG0665@2|Bacteria,2G6XM@200795|Chloroflexi	200795|Chloroflexi	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00301	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
CMS3_k127_6111297_3	661478.OP10G_1553	1.432e-56	222.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_6111297_4	880073.Calab_3333	2.879e-52	196.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6112185_0	314230.DSM3645_09952	1.304e-129	427.0	COG1506@1|root,COG1506@2|Bacteria,2J51R@203682|Planctomycetes	203682|Planctomycetes	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6128923_2	1123508.JH636444_gene5664	1.064e-07	58.0	COG0500@1|root,COG2226@2|Bacteria,2IZR2@203682|Planctomycetes	203682|Planctomycetes	Q	COG2226 Methylase involved in ubiquinone menaquinone biosynthesis	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
CMS3_k127_6128923_0	314230.DSM3645_29152	1.306e-40	164.0	2DMKI@1|root,32S70@2|Bacteria,2J03R@203682|Planctomycetes	203682|Planctomycetes	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
CMS3_k127_6128923_3	1214242.B446_00790	7.07e-05	51.0	COG3485@1|root,COG3485@2|Bacteria,2GMAP@201174|Actinobacteria	201174|Actinobacteria	Q	dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Dioxygenase_C
CMS3_k127_6129038_1	161156.JQKW01000006_gene1394	2.12e-62	222.0	COG2518@1|root,COG2518@2|Bacteria,2GH2E@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CMS3_k127_6129038_3	1121129.KB903359_gene1878	2.069e-08	67.0	COG3746@1|root,COG3746@2|Bacteria,4NISD@976|Bacteroidetes,2FRA6@200643|Bacteroidia,231ZA@171551|Porphyromonadaceae	976|Bacteroidetes	P	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6129038_2	395961.Cyan7425_3349	6.416e-29	133.0	COG2251@1|root,COG2251@2|Bacteria,1G03D@1117|Cyanobacteria,3KG1W@43988|Cyanothece	1117|Cyanobacteria	S	RNase_H superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas4,RNase_H_2
CMS3_k127_6129038_0	357808.RoseRS_0056	3.556e-76	279.0	COG1061@1|root,COG1112@1|root,COG1061@2|Bacteria,COG1112@2|Bacteria,2GB6S@200795|Chloroflexi,377GI@32061|Chloroflexia	32061|Chloroflexia	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12
CMS3_k127_6132736_3	1122939.ATUD01000012_gene3173	6.052e-48	182.0	2ASH4@1|root,31HXG@2|Bacteria,2HMFJ@201174|Actinobacteria,4CQBD@84995|Rubrobacteria	84995|Rubrobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_6132736_4	1122201.AUAZ01000003_gene2074	9.497e-38	147.0	COG0824@1|root,COG0824@2|Bacteria,1RF7Q@1224|Proteobacteria,1S7PD@1236|Gammaproteobacteria,468NH@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_2
CMS3_k127_6132736_6	215803.DB30_2422	1.156e-16	96.0	COG0750@1|root,COG4932@1|root,COG0750@2|Bacteria,COG4932@2|Bacteria,1NXIX@1224|Proteobacteria,430KM@68525|delta/epsilon subdivisions,2WVSB@28221|Deltaproteobacteria,2YYGY@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_6132736_0	1033802.SSPSH_001227	2.101e-282	882.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,1RPM0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iSF_1195.SF3422,iUTI89_1310.UTI89_C3903	PEPCK_ATP
CMS3_k127_6132736_2	706587.Desti_5065	9.402e-75	258.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2MRKV@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM response regulator receiver	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_6132736_1	357804.Ping_0836	2.238e-114	390.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,2QHI3@267894|Psychromonadaceae	1236|Gammaproteobacteria	T	histidine kinase A domain protein domain protein	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS_4,PAS_8
CMS3_k127_6132736_5	439235.Dalk_1431	3.724e-26	111.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2WN1U@28221|Deltaproteobacteria,2MICR@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
CMS3_k127_613969_2	234267.Acid_7491	5.121e-15	85.0	COG1215@1|root,COG2227@1|root,COG1215@2|Bacteria,COG2227@2|Bacteria,3Y7EP@57723|Acidobacteria	57723|Acidobacteria	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_23
CMS3_k127_613969_1	429009.Adeg_1154	2.836e-78	276.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,42F9V@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM DAHP synthetase I KDSA	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
CMS3_k127_613969_0	338966.Ppro_0804	6.31e-85	297.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
CMS3_k127_6143086_1	243090.RB8028	2.427e-72	259.0	COG0515@1|root,COG0515@2|Bacteria,2J0PH@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_6143086_0	395493.BegalDRAFT_0901	2.603e-157	508.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,45ZZ4@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
CMS3_k127_6144950_3	471854.Dfer_1179	3.476e-16	91.0	COG2304@1|root,COG4409@1|root,COG2304@2|Bacteria,COG4409@2|Bacteria,4NFNQ@976|Bacteroidetes,47RTU@768503|Cytophagia	976|Bacteroidetes	G	IgA Peptidase M64	-	-	-	-	-	-	-	-	-	-	-	-	M64_N,Peptidase_M64
CMS3_k127_6144950_0	448385.sce8244	1.947e-50	188.0	COG2453@1|root,COG2453@2|Bacteria,1QSUD@1224|Proteobacteria,43A8J@68525|delta/epsilon subdivisions,2X3DG@28221|Deltaproteobacteria,2YVJ1@29|Myxococcales	28221|Deltaproteobacteria	T	Dual specificity phosphatase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DSPc
CMS3_k127_6144950_1	1385520.N802_10680	3.095e-49	188.0	2EANZ@1|root,334RH@2|Bacteria,2ICX0@201174|Actinobacteria	201174|Actinobacteria	S	Suppressor of fused protein (SUFU)	-	-	-	-	-	-	-	-	-	-	-	-	SUFU
CMS3_k127_6144950_2	509191.AEDB02000002_gene1292	1.255e-32	131.0	2E7WX@1|root,332BH@2|Bacteria,1VJGZ@1239|Firmicutes,24V84@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6144950_4	94122.Shewana3_3897	0.0007193	49.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,2Q9DU@267890|Shewanellaceae	1236|Gammaproteobacteria	NU	PFAM Pilus assembly protein PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
CMS3_k127_6145860_1	1304872.JAGC01000009_gene994	3.911e-43	167.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,42NF2@68525|delta/epsilon subdivisions,2WJ7Q@28221|Deltaproteobacteria,2M8H7@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Cell wall formation	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
CMS3_k127_6145860_0	457425.XNR_1128	7.644e-62	222.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
CMS3_k127_614782_0	344747.PM8797T_07699	2.653e-101	336.0	COG2755@1|root,COG2755@2|Bacteria,2IWSK@203682|Planctomycetes	203682|Planctomycetes	E	N-terminus of Esterase_SGNH_hydro-type	-	-	-	-	-	-	-	-	-	-	-	-	GxDLY,Lipase_GDSL_3
CMS3_k127_614782_1	1121918.ARWE01000001_gene1451	1.148e-13	83.0	COG0457@1|root,COG0457@2|Bacteria,1QXGV@1224|Proteobacteria,42RIF@68525|delta/epsilon subdivisions,2WNC6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
CMS3_k127_614910_3	1177154.Y5S_02125	2.026e-93	310.0	COG0069@1|root,COG2146@1|root,COG0069@2|Bacteria,COG2146@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,1XIUD@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the glutamate synthase family	-	-	2.1.1.21	ko:K22083	ko00680,ko01120,map00680,map01120	-	R01586	RC00554	ko00000,ko00001,ko01000	-	-	-	Glu_synthase,zf-CDGSH
CMS3_k127_614910_4	640511.BC1002_1279	1.055e-77	270.0	COG0491@1|root,COG0491@2|Bacteria,1NMU0@1224|Proteobacteria,2W825@28216|Betaproteobacteria,1K57H@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13,Lactamase_B_5
CMS3_k127_614910_0	1121904.ARBP01000003_gene6372	7.132e-280	869.0	COG2382@1|root,COG2382@2|Bacteria,4NGBK@976|Bacteroidetes,47K7D@768503|Cytophagia	976|Bacteroidetes	P	esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS3_k127_614910_2	1279017.AQYJ01000029_gene3659	2.317e-112	379.0	28HGI@1|root,2Z7SC@2|Bacteria,1MWKC@1224|Proteobacteria,1SM99@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_614910_1	443143.GM18_0105	8.335e-228	726.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,42QGH@68525|delta/epsilon subdivisions,2WKTM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM multicopper oxidase type 2	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2
CMS3_k127_6158819_2	1142394.PSMK_02700	5.19e-18	93.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt_3,Polysacc_synt_C
CMS3_k127_6158819_0	118163.Ple7327_1369	2.99e-65	236.0	COG2242@1|root,COG2242@2|Bacteria,1G543@1117|Cyanobacteria,3VKQU@52604|Pleurocapsales	1117|Cyanobacteria	H	Vibrio cholerae RfbT protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
CMS3_k127_6158819_1	861299.J421_5776	5.82e-31	135.0	COG0438@1|root,COG0438@2|Bacteria,1ZV1E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4
CMS3_k127_616191_2	1173026.Glo7428_3606	1.324e-26	123.0	COG5563@1|root,COG5563@2|Bacteria,1GASM@1117|Cyanobacteria	1117|Cyanobacteria	S	Extracellular repeat protein, HAF family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3466
CMS3_k127_616191_1	63737.Npun_F5437	4.396e-60	218.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	ubiE11	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
CMS3_k127_616191_0	1122939.ATUD01000001_gene577	1.175e-185	617.0	COG1520@1|root,COG1520@2|Bacteria,2H3K4@201174|Actinobacteria,4CRJK@84995|Rubrobacteria	84995|Rubrobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6162291_4	1210884.HG799464_gene10586	2.509e-16	86.0	COG1657@1|root,COG1657@2|Bacteria,2IXWD@203682|Planctomycetes	203682|Planctomycetes	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
CMS3_k127_6162291_3	228410.NE0622	7.994e-22	106.0	COG0662@1|root,COG0662@2|Bacteria,1RFTK@1224|Proteobacteria,2WG1F@28216|Betaproteobacteria,374QB@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_6162291_1	550540.Fbal_3347	3.836e-23	110.0	2DTF7@1|root,33K38@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6162291_2	1379270.AUXF01000005_gene474	2.523e-22	111.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZSZA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS3_k127_6162291_0	595460.RRSWK_04098	3.859e-269	878.0	COG3119@1|root,COG4946@1|root,COG3119@2|Bacteria,COG4946@2|Bacteria,2IY4Z@203682|Planctomycetes	203682|Planctomycetes	M	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6188750_2	1210884.HG799473_gene15023	2.144e-120	404.0	COG0823@1|root,COG1506@1|root,COG2866@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,COG2866@2|Bacteria,2J1EY@203682|Planctomycetes	203682|Planctomycetes	E	Zinc carboxypeptidase	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_M14,Peptidase_S9
CMS3_k127_6188750_7	518766.Rmar_1830	6.294e-20	94.0	COG0308@1|root,COG0308@2|Bacteria,4NFNJ@976|Bacteroidetes,1FK1K@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
CMS3_k127_6188750_10	1223410.KN050846_gene2719	4.891e-06	55.0	COG1595@1|root,COG1595@2|Bacteria,4NSVA@976|Bacteroidetes,1I0Q1@117743|Flavobacteriia	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6188750_0	1123256.KB907926_gene972	5.139e-211	667.0	COG0659@1|root,COG0659@2|Bacteria,1MXA7@1224|Proteobacteria,1RQYD@1236|Gammaproteobacteria,1X46G@135614|Xanthomonadales	135614|Xanthomonadales	P	secondary active sulfate transmembrane transporter activity	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	-
CMS3_k127_6188750_1	269799.Gmet_1965	9.703e-145	492.0	COG3868@1|root,COG3868@2|Bacteria,1NXBJ@1224|Proteobacteria,430FT@68525|delta/epsilon subdivisions,2WVXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6188750_4	1298880.AUEV01000007_gene4573	9.59e-44	162.0	COG0346@1|root,COG0346@2|Bacteria,2IQE0@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_6188750_9	63737.Npun_R2919	1.569e-08	67.0	COG2931@1|root,COG2931@2|Bacteria,1G6DF@1117|Cyanobacteria,1HMIC@1161|Nostocales	1117|Cyanobacteria	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS3_k127_6188750_8	488538.SAR116_1354	1.792e-09	68.0	2BZ7H@1|root,34C4G@2|Bacteria,1P3BN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6188750_3	1403819.BATR01000087_gene2581	1.454e-117	396.0	COG0443@1|root,COG0443@2|Bacteria,46SDM@74201|Verrucomicrobia,2ITH0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	MreB/Mbl protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
CMS3_k127_6188750_6	1205908.AKXW01000066_gene2907	4.585e-25	120.0	COG3793@1|root,COG3793@2|Bacteria,1NS76@1224|Proteobacteria	1224|Proteobacteria	P	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
CMS3_k127_6188750_5	488538.SAR116_1357	1.766e-28	129.0	COG0501@1|root,COG0501@2|Bacteria,1PW7F@1224|Proteobacteria,2UX3D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CMS3_k127_6199092_3	290397.Adeh_0766	2.579e-20	91.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42PGQ@68525|delta/epsilon subdivisions,2WMJB@28221|Deltaproteobacteria,2YUUP@29|Myxococcales	28221|Deltaproteobacteria	C	Cysteine-rich domain	glpC	-	1.1.5.3	ko:K00113	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17,Fer4_8
CMS3_k127_6199092_1	404589.Anae109_0813	2.211e-53	196.0	COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,43DRN@68525|delta/epsilon subdivisions,2WYQA@28221|Deltaproteobacteria,2Z0CV@29|Myxococcales	28221|Deltaproteobacteria	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
CMS3_k127_6199092_4	96561.Dole_2766	2.053e-12	80.0	COG3420@1|root,COG3420@2|Bacteria,1NGNA@1224|Proteobacteria,43156@68525|delta/epsilon subdivisions,2WW9W@28221|Deltaproteobacteria,2MNX1@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS3_k127_6199092_0	935863.AWZR01000007_gene259	2.199e-65	244.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1X3XJ@135614|Xanthomonadales	1236|Gammaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm2	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CMS3_k127_6199092_2	983917.RGE_30170	5.773e-24	109.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	-	-	-	ko:K03830	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,YiiD_C
CMS3_k127_6201201_4	1158318.ATXC01000002_gene1501	1.083e-54	198.0	COG0264@1|root,COG0264@2|Bacteria,2G3RA@200783|Aquificae	200783|Aquificae	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
CMS3_k127_6201201_2	1125863.JAFN01000001_gene968	4.454e-86	291.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
CMS3_k127_6201201_3	756272.Plabr_4345	4.64e-57	205.0	COG0233@1|root,COG0233@2|Bacteria,2IYYY@203682|Planctomycetes	203682|Planctomycetes	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
CMS3_k127_6201201_6	1313304.CALK_0130	2.137e-13	75.0	COG2835@1|root,COG2835@2|Bacteria	2|Bacteria	EG	tetraacyldisaccharide 4'-kinase activity	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Methyltransf_25,Trm112p
CMS3_k127_6201201_5	378806.STAUR_4674	1.746e-24	119.0	COG0500@1|root,COG0500@2|Bacteria,1NT9Y@1224|Proteobacteria	1224|Proteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
CMS3_k127_6201201_0	266834.SM_b21056	9.358e-183	596.0	COG3291@1|root,COG3828@1|root,COG3291@2|Bacteria,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,UnbV_ASPIC,VCBS
CMS3_k127_6201201_1	118163.Ple7327_1370	2.997e-164	532.0	28JSS@1|root,2Z9I4@2|Bacteria,1G4V8@1117|Cyanobacteria,3VIGX@52604|Pleurocapsales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6205362_2	406124.ACPC01000046_gene2381	6.669e-36	156.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HANF@91061|Bacilli,1ZS27@1386|Bacillus	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_6205362_1	596153.Alide_0314	4.836e-59	212.0	COG0745@1|root,COG0745@2|Bacteria,1Q2S0@1224|Proteobacteria,2VM6W@28216|Betaproteobacteria,4AAMQ@80864|Comamonadaceae	28216|Betaproteobacteria	K	Two component transcriptional regulator	ompR2	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_6205362_0	530564.Psta_3499	6.801e-77	261.0	COG2960@1|root,COG2960@2|Bacteria,2IYQY@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
CMS3_k127_6210308_0	1122939.ATUD01000001_gene577	5.074e-162	546.0	COG1520@1|root,COG1520@2|Bacteria,2H3K4@201174|Actinobacteria,4CRJK@84995|Rubrobacteria	84995|Rubrobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6210308_1	28377.ENSACAP00000012160	1.226e-15	90.0	KOG1217@1|root,KOG1217@2759|Eukaryota,38BUP@33154|Opisthokonta,3BAFT@33208|Metazoa,3CRZB@33213|Bilateria,485Y1@7711|Chordata,48WDE@7742|Vertebrata	33208|Metazoa	T	neurogenic locus notch homolog protein	NOTCH4	-	-	ko:K02599,ko:K20996	ko01522,ko04320,ko04330,ko04658,ko04919,ko05020,ko05165,ko05200,ko05206,ko05224,map01522,map04320,map04330,map04658,map04919,map05020,map05165,map05200,map05206,map05224	M00682	-	-	ko00000,ko00001,ko00002	-	-	-	Ank_2,Ank_3,DUF3454,EGF,EGF_CA,NOD,NODP,Notch,hEGF
CMS3_k127_6218392_2	247490.KSU1_C1034	1.073e-41	155.0	COG3861@1|root,COG3861@2|Bacteria,2IZRE@203682|Planctomycetes	203682|Planctomycetes	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	PRC
CMS3_k127_6218392_3	1121013.P873_02135	8.603e-33	138.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,1RNSP@1236|Gammaproteobacteria,1X5WP@135614|Xanthomonadales	135614|Xanthomonadales	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS3_k127_6218392_1	1449126.JQKL01000005_gene942	4.484e-70	260.0	COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,247UR@186801|Clostridia,267NX@186813|unclassified Clostridiales	186801|Clostridia	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
CMS3_k127_6218392_0	794903.OPIT5_07730	2.038e-111	368.0	COG0330@1|root,COG0330@2|Bacteria,46SQ6@74201|Verrucomicrobia	74201|Verrucomicrobia	O	HflC and HflK could regulate a protease	-	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
CMS3_k127_622713_0	85982.XP_007324125.1	8.504e-11	76.0	KOG0271@1|root,KOG0271@2759|Eukaryota,3AGU6@33154|Opisthokonta,3Q4J3@4751|Fungi,3V7B1@5204|Basidiomycota,22FCW@155619|Agaricomycetes	4751|Fungi	U	WD40 repeat-like protein	-	-	-	ko:K14855	-	-	-	-	ko00000,ko03009	-	-	-	NACHT,WD40
CMS3_k127_622713_1	40492.XP_007305763.1	1.356e-06	62.0	KOG0266@1|root,KOG0266@2759|Eukaryota,38B6D@33154|Opisthokonta,3NZ4C@4751|Fungi,3V7KW@5204|Basidiomycota,228W3@155619|Agaricomycetes,3H6XD@355688|Agaricomycetes incertae sedis	4751|Fungi	S	WD40 repeat-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,C2,NACHT,WD40
CMS3_k127_6228705_0	1122179.KB890419_gene24	1.02e-290	911.0	COG4447@1|root,COG4447@2|Bacteria,4NI14@976|Bacteroidetes	976|Bacteroidetes	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
CMS3_k127_6250536_0	1254432.SCE1572_07685	3.54e-54	214.0	COG1351@1|root,COG1351@2|Bacteria,1NRE8@1224|Proteobacteria	1224|Proteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
CMS3_k127_6250536_1	1131269.AQVV01000038_gene1561	6.633e-54	206.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	bacE	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
CMS3_k127_6250536_2	69042.WH5701_06706	8.444e-43	166.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1G1K0@1117|Cyanobacteria,1GYZM@1129|Synechococcus	1117|Cyanobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
CMS3_k127_6256879_1	1415166.NONO_c33920	1.521e-10	71.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,4FV95@85025|Nocardiaceae	201174|Actinobacteria	L	PD-(D/E)XK nuclease superfamily	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
CMS3_k127_6256879_0	330214.NIDE2086	1.095e-84	319.0	COG1074@1|root,COG1074@2|Bacteria,3J16M@40117|Nitrospirae	40117|Nitrospirae	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
CMS3_k127_6257839_1	292459.STH292	2.441e-25	121.0	COG2971@1|root,COG2971@2|Bacteria,1V0VG@1239|Firmicutes,24BFK@186801|Clostridia	186801|Clostridia	G	BadF BadG BcrA BcrD	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006040,GO:0006044,GO:0006082,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0045127,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901071,GO:1901135,GO:1901265,GO:1901363	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
CMS3_k127_6257839_0	880073.Calab_0272	3.593e-36	150.0	COG1649@1|root,COG3023@1|root,COG3391@1|root,COG4412@1|root,COG1649@2|Bacteria,COG3023@2|Bacteria,COG3391@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	3.2.1.20,3.4.17.22,3.5.1.28	ko:K01187,ko:K01448,ko:K07752	ko00052,ko00500,ko01100,ko01503,map00052,map00500,map01100,map01503	M00727	R00028,R00801,R00802,R04112,R06087,R06088	RC00028,RC00049,RC00064,RC00077,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko03036	-	GH31	-	Amidase_2
CMS3_k127_6258356_1	633149.Bresu_0368	3.669e-14	81.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2TQZW@28211|Alphaproteobacteria,2KFRG@204458|Caulobacterales	204458|Caulobacterales	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
CMS3_k127_6258356_0	673860.AciM339_1448	8.038e-71	258.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,3F2F5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	PFAM aspartate ornithine carbamoyltransferase carbamoyl-P binding domain	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1168	OTCace,OTCace_N
CMS3_k127_6265594_2	502025.Hoch_6354	2.476e-22	106.0	COG2706@1|root,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS3_k127_6265594_4	62928.azo0278	1.78e-08	68.0	2EFNF@1|root,339EK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6265594_0	1499967.BAYZ01000076_gene756	5.063e-139	449.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS3_k127_6265594_1	1313172.YM304_04550	4.318e-63	232.0	COG2146@1|root,COG2146@2|Bacteria,2GQWS@201174|Actinobacteria	201174|Actinobacteria	P	Rieske [2Fe-2S] domain	-	-	-	ko:K15762	ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220	M00538	R02550,R03562,R05666,R09513	RC00269,RC00490,RC02556	ko00000,ko00001,ko00002	-	-	-	Rieske
CMS3_k127_6278958_0	862908.BMS_2421	9.134e-80	280.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,42YFC@68525|delta/epsilon subdivisions,2MTMM@213481|Bdellovibrionales,2WU03@28221|Deltaproteobacteria	213481|Bdellovibrionales	I	desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
CMS3_k127_6278958_1	530564.Psta_2991	1.718e-37	154.0	28I0W@1|root,30QX6@2|Bacteria,2IZI8@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6278958_2	240015.ACP_1938	6.494e-06	59.0	COG1807@1|root,COG1807@2|Bacteria,3Y46U@57723|Acidobacteria,2JIQH@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_6278991_0	42256.RradSPS_2475	9.185e-91	314.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2GKFE@201174|Actinobacteria,4CRQ6@84995|Rubrobacteria	84995|Rubrobacteria	C	COG COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit Energy production and conversion	-	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K11381,ko:K21417	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS3_k127_6306412_6	504728.K649_02985	1.179e-07	53.0	COG0333@1|root,COG0333@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
CMS3_k127_6306412_2	498761.HM1_2161	2.941e-79	276.0	COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia	186801|Clostridia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
CMS3_k127_6306412_1	382464.ABSI01000010_gene3377	5.256e-102	342.0	COG0332@1|root,COG0332@2|Bacteria,46SE2@74201|Verrucomicrobia,2ITMR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS3_k127_6306412_3	572477.Alvin_1891	1.208e-75	261.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,1WXR9@135613|Chromatiales	135613|Chromatiales	IQ	PFAM Short-chain dehydrogenase reductase SDR	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_6306412_4	639282.DEFDS_0153	1.755e-23	101.0	COG0236@1|root,COG0236@2|Bacteria,2GG1C@200930|Deferribacteres	200930|Deferribacteres	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CMS3_k127_6306412_0	648996.Theam_0611	4.692e-145	470.0	COG0304@1|root,COG0304@2|Bacteria,2G3SR@200783|Aquificae	200783|Aquificae	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS3_k127_6306412_5	1122223.KB890699_gene621	8.748e-21	98.0	COG1181@1|root,COG1181@2|Bacteria,1WIJ8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
CMS3_k127_6306785_3	1121904.ARBP01000010_gene2339	6.068e-32	129.0	COG3369@1|root,COG3369@2|Bacteria,4NW9E@976|Bacteroidetes,47W0Y@768503|Cytophagia	976|Bacteroidetes	S	Iron-binding zinc finger CDGSH type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
CMS3_k127_6306785_1	391625.PPSIR1_32824	9.852e-98	329.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,42T7F@68525|delta/epsilon subdivisions,2WP8W@28221|Deltaproteobacteria,2YWFQ@29|Myxococcales	28221|Deltaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
CMS3_k127_6306785_0	1123368.AUIS01000015_gene2648	4.276e-123	401.0	COG0435@1|root,COG0435@2|Bacteria,1MV50@1224|Proteobacteria,1RMTI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Glutathione S-Transferase	yqjG	-	1.8.5.7	ko:K07393	-	-	-	-	ko00000,ko01000	-	-	-	GST_C_2,GST_N_2
CMS3_k127_6306785_2	292415.Tbd_1470	4.743e-34	132.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_5
CMS3_k127_6310045_1	1121123.AUAO01000003_gene2394	1.8e-124	407.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,2KIF5@204458|Caulobacterales	204458|Caulobacterales	E	Membrane dipeptidase (Peptidase family M19)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M19
CMS3_k127_6310045_2	574087.Acear_2061	2.55e-27	120.0	COG2339@1|root,COG2339@2|Bacteria,1UZGQ@1239|Firmicutes,24D4U@186801|Clostridia,3WBU4@53433|Halanaerobiales	186801|Clostridia	S	Protease prsW family	prsW	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
CMS3_k127_6310045_0	1123508.JH636452_gene7057	1.811e-162	529.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,2J2J0@203682|Planctomycetes	203682|Planctomycetes	S	Vault protein inter-alpha-trypsin domain	-	-	-	-	-	-	-	-	-	-	-	-	VIT,VWA_3
CMS3_k127_6317129_4	1122138.AQUZ01000056_gene6927	0.000619	50.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992,ko:K19341	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC2_membrane_2,ABC2_membrane_3
CMS3_k127_6317129_0	1396141.BATP01000005_gene6079	8.939e-42	168.0	COG1131@1|root,COG1131@2|Bacteria,46U5D@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_6317129_3	573413.Spirs_3894	1.633e-12	72.0	COG1725@1|root,COG1725@2|Bacteria,2J8U7@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, GntR family	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS3_k127_6317129_2	1499967.BAYZ01000158_gene436	1.623e-21	102.0	COG1664@1|root,COG1664@2|Bacteria,2NQ1N@2323|unclassified Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
CMS3_k127_6317129_1	700598.Niako_0701	1.409e-35	141.0	COG1649@1|root,COG1649@2|Bacteria,4NFKQ@976|Bacteroidetes,1IQ50@117747|Sphingobacteriia	976|Bacteroidetes	S	Glycosyl hydrolase-like 10	yngK	-	-	-	-	-	-	-	-	-	-	-	GHL10
CMS3_k127_6318994_1	523791.Kkor_1344	4.455e-172	555.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RMUK@1236|Gammaproteobacteria,1XHV1@135619|Oceanospirillales	135619|Oceanospirillales	P	nitrate nitrite transporter	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
CMS3_k127_6318994_2	653733.Selin_2440	3.182e-61	224.0	COG2181@1|root,COG2181@2|Bacteria	2|Bacteria	C	nitrate reductase activity	narI	GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0036293,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070469,GO:0070470,GO:0070482,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204	1.7.5.1	ko:K00370,ko:K00374,ko:K02575	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00615,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.1.8,5.A.3.1	-	iEC042_1314.EC042_1594,iECABU_c1320.ECABU_c17020,iECUMN_1333.ECUMN_1718,iNJ661.Rv1164,iSF_1195.SF1230,ic_1306.c1897	Nitrate_red_gam
CMS3_k127_6318994_4	94624.Bpet4991	6.177e-18	90.0	COG2180@1|root,COG2180@2|Bacteria,1MY4E@1224|Proteobacteria,2VQI7@28216|Betaproteobacteria,3T45V@506|Alcaligenaceae	28216|Betaproteobacteria	C	Nitrate reductase	narJ	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
CMS3_k127_6318994_0	314278.NB231_16088	2.781e-217	684.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,1RNMJ@1236|Gammaproteobacteria,1X0R3@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
CMS3_k127_6318994_3	1121920.AUAU01000008_gene1619	2.102e-43	159.0	COG5013@1|root,COG5013@2|Bacteria	2|Bacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0042126,GO:0043436,GO:0043546,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0097159,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204,GO:2001057	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	iSBO_1134.SBO_1842,iUMN146_1321.UM146_09685	Molybdopterin,Molydop_binding,Nitr_red_alph_N
CMS3_k127_631909_2	1051632.TPY_1321	3.755e-97	321.0	COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,249W6@186801|Clostridia	186801|Clostridia	F	PFAM amidohydrolase	hydA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
CMS3_k127_631909_0	378806.STAUR_8044	2.076e-184	595.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria,2YWB2@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_631909_1	391625.PPSIR1_32307	2.611e-148	481.0	COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,42YD3@68525|delta/epsilon subdivisions,2WTVV@28221|Deltaproteobacteria,2YU0M@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	yeiA	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_21
CMS3_k127_6321712_0	439235.Dalk_4702	3.696e-129	423.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,2MHKB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
CMS3_k127_6321712_1	1000565.METUNv1_03416	1.175e-26	127.0	COG0642@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVXP@206389|Rhodocyclales	206389|Rhodocyclales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
CMS3_k127_632720_1	1089550.ATTH01000002_gene32	2.095e-67	236.0	COG0670@1|root,COG0670@2|Bacteria,4NFZ7@976|Bacteroidetes	976|Bacteroidetes	S	Belongs to the BI1 family	-	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
CMS3_k127_632720_0	463191.SSEG_09893	2.408e-141	459.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_632720_3	1192034.CAP_0198	1.31e-31	127.0	COG3795@1|root,COG3795@2|Bacteria,1N32U@1224|Proteobacteria,432ET@68525|delta/epsilon subdivisions,2X94U@28221|Deltaproteobacteria,2Z1Y0@29|Myxococcales	28221|Deltaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
CMS3_k127_632720_2	1121904.ARBP01000012_gene1295	1.527e-43	170.0	2EFSK@1|root,339IK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx1
CMS3_k127_6333626_1	1123242.JH636438_gene5880	6.936e-42	175.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
CMS3_k127_6333626_0	314230.DSM3645_11502	5.476e-57	200.0	COG4102@1|root,COG4102@2|Bacteria,2IX70@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_6336199_2	1142394.PSMK_06260	0.0005737	52.0	COG0308@1|root,COG0308@2|Bacteria	2|Bacteria	E	peptide catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2
CMS3_k127_6336199_1	105559.Nwat_0599	1.04e-11	74.0	COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1X0AY@135613|Chromatiales	135613|Chromatiales	V	MATE efflux family protein	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
CMS3_k127_6336199_0	886293.Sinac_2659	6.775e-13	77.0	COG0367@1|root,COG0367@2|Bacteria,2J23D@203682|Planctomycetes	203682|Planctomycetes	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS3_k127_6346935_0	1123368.AUIS01000011_gene1139	1.115e-100	361.0	COG1404@1|root,COG1404@2|Bacteria,1R90Q@1224|Proteobacteria,1S01H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
CMS3_k127_6348985_2	234267.Acid_5975	7.998e-86	312.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3V0@57723|Acidobacteria	2|Bacteria	EU	peptidase S9B dipeptidylpeptidase IV domain protein	ptpA_1	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,PD40,Peptidase_S9
CMS3_k127_6348985_6	644966.Tmar_0963	3.485e-31	136.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24HHW@186801|Clostridia,3WDTC@538999|Clostridiales incertae sedis	186801|Clostridia	U	TIGRFAM signal peptidase I, bacterial type	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
CMS3_k127_6348985_7	1120954.ATXE01000001_gene2492	2.558e-24	111.0	COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria,4DPI8@85009|Propionibacteriales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
CMS3_k127_6348985_4	1240349.ANGC01000008_gene1004	1.433e-51	193.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,4FV7M@85025|Nocardiaceae	201174|Actinobacteria	Q	Domain of unknown function (DUF2437)	odx	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
CMS3_k127_6348985_3	1121396.KB892900_gene2131	6.392e-54	211.0	COG1657@1|root,COG1657@2|Bacteria,1RDNW@1224|Proteobacteria,42S7H@68525|delta/epsilon subdivisions,2WNQX@28221|Deltaproteobacteria,2MMUB@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	Prenyltrans
CMS3_k127_6348985_5	309807.SRU_1857	1.668e-34	142.0	COG3222@1|root,COG3222@2|Bacteria,4NM7F@976|Bacteroidetes,1FK4V@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
CMS3_k127_6348985_0	868864.Dester_0765	2.703e-112	374.0	COG0436@1|root,COG0436@2|Bacteria,2G3PX@200783|Aquificae	200783|Aquificae	E	PFAM Aminotransferase class I and II	dapC	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS3_k127_6348985_1	502025.Hoch_5272	2.921e-109	360.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,42SPQ@68525|delta/epsilon subdivisions,2WPX1@28221|Deltaproteobacteria,2YWQX@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
CMS3_k127_6350202_0	926566.Terro_0571	1.012e-09	70.0	COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria,3Y6C4@57723|Acidobacteria,2JM8A@204432|Acidobacteriia	204432|Acidobacteriia	E	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_637439_0	251229.Chro_0081	6.45e-30	134.0	COG0697@1|root,COG0697@2|Bacteria,1G0QG@1117|Cyanobacteria,3VJGM@52604|Pleurocapsales	1117|Cyanobacteria	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_638181_1	237368.SCABRO_01840	1.371e-162	527.0	COG0624@1|root,COG1181@1|root,COG0624@2|Bacteria,COG1181@2|Bacteria,2IZEV@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
CMS3_k127_638181_0	1249627.D779_2280	3.412e-184	589.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1WWYZ@135613|Chromatiales	135613|Chromatiales	E	PFAM Gamma-glutamyltranspeptidase	-	-	-	-	-	-	-	-	-	-	-	-	G_glu_transpept
CMS3_k127_6383369_0	1411685.U062_02083	2.069e-24	118.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1J53S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	GO:0001680,GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016437,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042245,GO:0042780,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990817	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
CMS3_k127_6383587_2	1380393.JHVP01000002_gene1761	3.825e-71	253.0	COG1012@1|root,COG1012@2|Bacteria,2GKSN@201174|Actinobacteria,4EUCR@85013|Frankiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_6383587_0	1386089.N865_18185	4.358e-200	641.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FEZI@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_6383587_1	1869.MB27_40360	8.748e-95	321.0	COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria,4DADZ@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
CMS3_k127_6383587_3	1379698.RBG1_1C00001G0231	1.263e-08	64.0	COG1413@1|root,COG1413@2|Bacteria,2NRMK@2323|unclassified Bacteria	2|Bacteria	C	HEAT repeats	CP_0755	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Response_reg
CMS3_k127_6390640_4	864051.BurJ1DRAFT_3207	0.0001373	48.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,2VQRJ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
CMS3_k127_6390640_6	298653.Franean1_3065	0.0006898	49.0	COG3415@1|root,COG3415@2|Bacteria,2I3BN@201174|Actinobacteria	201174|Actinobacteria	L	Rhodopirellula transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013,HTH_Tnp_4
CMS3_k127_6390640_3	1205680.CAKO01000002_gene2680	3.915e-09	64.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497,ko:K09958	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,Mu-transpos_C,rve,rve_3
CMS3_k127_6390640_1	1183438.GKIL_0032	4.865e-41	175.0	COG0265@1|root,COG0265@2|Bacteria,1G3M4@1117|Cyanobacteria	2|Bacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	1.3.1.74	ko:K08070,ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_6390640_2	234267.Acid_1623	4.412e-35	138.0	COG2801@1|root,COG2801@2|Bacteria,3Y821@57723|Acidobacteria	57723|Acidobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
CMS3_k127_6390640_0	234267.Acid_1623	4.145e-61	229.0	COG2801@1|root,COG2801@2|Bacteria,3Y821@57723|Acidobacteria	57723|Acidobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
CMS3_k127_6407611_0	9258.ENSOANP00000025033	1.092e-10	75.0	COG2304@1|root,2QPS2@2759|Eukaryota,38C6V@33154|Opisthokonta,3BE0X@33208|Metazoa,3CW49@33213|Bilateria,4803N@7711|Chordata,4985B@7742|Vertebrata,3JEFA@40674|Mammalia	33208|Metazoa	S	inter-alpha-trypsin inhibitor heavy chain	ITIH5	-	-	-	-	-	-	-	-	-	-	-	ITI_HC_C,VIT,VWA,VWA_3
CMS3_k127_6407611_1	1121405.dsmv_1236	3.943e-10	68.0	2EB0T@1|root,3351P@2|Bacteria,1NJAF@1224|Proteobacteria,431ZP@68525|delta/epsilon subdivisions,2WW83@28221|Deltaproteobacteria,2MNY6@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6408155_2	1150474.JQJI01000048_gene1241	1.136e-27	114.0	COG0444@1|root,COG0444@2|Bacteria,2GCKF@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
CMS3_k127_6408155_0	1123389.ATXJ01000011_gene1063	1.839e-121	401.0	COG4608@1|root,COG4608@2|Bacteria,1WI6F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the ABC transporter superfamily	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_6408155_5	448385.sce1844	4.436e-07	64.0	COG4932@1|root,COG4932@2|Bacteria,1Q2N2@1224|Proteobacteria,4388V@68525|delta/epsilon subdivisions,2X3IH@28221|Deltaproteobacteria,2YW8A@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,PDZ_2
CMS3_k127_6408155_4	44060.JODL01000003_gene2708	1.994e-10	75.0	COG1595@1|root,COG1595@2|Bacteria,2IKVM@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	sig49	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6408155_3	1333523.L593_04835	1.519e-26	121.0	COG0589@1|root,arCOG00449@2157|Archaea,2XU1P@28890|Euryarchaeota,23SZU@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Usp
CMS3_k127_6408155_1	269799.Gmet_1232	6.481e-41	164.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,42NEZ@68525|delta/epsilon subdivisions,2WJ5R@28221|Deltaproteobacteria,43U4X@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
CMS3_k127_6414726_0	1123508.JH636452_gene7057	0.0	1439.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,2J2J0@203682|Planctomycetes	203682|Planctomycetes	S	Vault protein inter-alpha-trypsin domain	-	-	-	-	-	-	-	-	-	-	-	-	VIT,VWA_3
CMS3_k127_6441188_0	13035.Dacsa_2599	5.357e-50	179.0	COG0229@1|root,COG0229@2|Bacteria,1G5S6@1117|Cyanobacteria	1117|Cyanobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
CMS3_k127_6455526_1	477974.Daud_1770	6.295e-108	364.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,261AB@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	pseC	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS3_k127_6455526_0	237368.SCABRO_03643	9.981e-121	399.0	COG1086@1|root,COG1086@2|Bacteria,2IWVA@203682|Planctomycetes	203682|Planctomycetes	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_2
CMS3_k127_6456795_0	1459636.NTE_01518	1.587e-11	76.0	COG3945@1|root,arCOG01471@2157|Archaea,41T3D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Hemerythrin HHE cation binding	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
CMS3_k127_6471260_0	1125863.JAFN01000001_gene1923	3.591e-05	56.0	COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,42U8K@68525|delta/epsilon subdivisions,2WPZ9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6476670_0	1379698.RBG1_1C00001G1092	1.357e-74	277.0	COG2866@1|root,COG4412@1|root,COG2866@2|Bacteria,COG4412@2|Bacteria,2NPI7@2323|unclassified Bacteria	2|Bacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.4.17.18,3.4.17.22	ko:K05996,ko:K07752	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	F5_F8_type_C,Peptidase_M14,Peptidase_M6,Ricin_B_lectin,fn3
CMS3_k127_6476670_1	1449976.KALB_5374	2.147e-09	71.0	COG1404@1|root,COG2866@1|root,COG1404@2|Bacteria,COG2866@2|Bacteria,2GJ14@201174|Actinobacteria,4DZY7@85010|Pseudonocardiales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	P_proprotein,Peptidase_S8
CMS3_k127_6485051_2	877455.Metbo_1958	1.294e-10	74.0	COG1520@1|root,COG3291@1|root,arCOG02487@1|root,arCOG02516@1|root,arCOG02555@1|root,arCOG09729@1|root,arCOG02487@2157|Archaea,arCOG02492@2157|Archaea,arCOG02508@2157|Archaea,arCOG02516@2157|Archaea,arCOG02555@2157|Archaea,arCOG09729@2157|Archaea	2157|Archaea	E	Polymorphic membrane protein, Chlamydia	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Big_5,CBM_6,CHB_HEX_C_1,NosD,PKD,PQQ_3,SBBP
CMS3_k127_6485051_1	234267.Acid_0975	2.235e-196	622.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501,Sulfatase
CMS3_k127_6485051_0	234267.Acid_0974	1.121e-275	880.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
CMS3_k127_6485051_3	89187.ISM_05500	2.422e-10	74.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,46NDX@74030|Roseovarius	28211|Alphaproteobacteria	O	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	degPch1	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_6485501_0	247490.KSU1_D0970	1.76e-93	326.0	COG1473@1|root,COG1473@2|Bacteria,2IY78@203682|Planctomycetes	203682|Planctomycetes	S	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_6485501_3	246197.MXAN_3713	0.0007852	53.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,42M74@68525|delta/epsilon subdivisions,2WPVT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_6485501_2	869210.Marky_1925	5.279e-26	124.0	COG0612@1|root,COG0612@2|Bacteria,1WM19@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_6485501_1	868595.Desca_2698	3.186e-79	293.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,260NB@186807|Peptococcaceae	186801|Clostridia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
CMS3_k127_6491830_1	251221.35214154	8.323e-36	155.0	COG1807@1|root,COG1807@2|Bacteria,1G0YQ@1117|Cyanobacteria	1117|Cyanobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
CMS3_k127_6491830_0	1121440.AUMA01000005_gene2582	5.689e-79	277.0	COG0859@1|root,COG0859@2|Bacteria,1PQIG@1224|Proteobacteria,42MUM@68525|delta/epsilon subdivisions,2WPZT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
CMS3_k127_6491900_2	1168059.KB899087_gene3453	2.09e-49	182.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2U58Z@28211|Alphaproteobacteria,3EY69@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
CMS3_k127_6491900_0	472759.Nhal_3208	5.712e-220	700.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1WVYK@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
CMS3_k127_6491900_1	562970.Btus_0496	1.514e-135	443.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,4H9Y4@91061|Bacilli,278X3@186823|Alicyclobacillaceae	91061|Bacilli	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
CMS3_k127_6491900_4	945713.IALB_1272	6e-21	103.0	COG0705@1|root,COG0705@2|Bacteria	2|Bacteria	S	proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS3_k127_6491900_3	1396141.BATP01000016_gene2844	4.486e-22	99.0	COG0755@1|root,COG0755@2|Bacteria,46VBM@74201|Verrucomicrobia,2IU24@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
CMS3_k127_6491946_5	1232666.JANE01000019_gene2371	4.74e-16	87.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,4HH0N@91061|Bacilli,4GXFR@90964|Staphylococcaceae	91061|Bacilli	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
CMS3_k127_6491946_2	562970.Btus_0141	2.792e-69	252.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,4HAK4@91061|Bacilli,278Y0@186823|Alicyclobacillaceae	91061|Bacilli	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
CMS3_k127_6491946_4	521674.Plim_0439	6.36e-49	182.0	COG0080@1|root,COG0080@2|Bacteria,2IZ97@203682|Planctomycetes	203682|Planctomycetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
CMS3_k127_6491946_3	247490.KSU1_C1196	2.5e-59	211.0	COG0250@1|root,COG0250@2|Bacteria,2IZ9N@203682|Planctomycetes	203682|Planctomycetes	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
CMS3_k127_6491946_7	243090.RB7897	2.568e-08	61.0	COG0690@1|root,COG0690@2|Bacteria,2J0E7@203682|Planctomycetes	203682|Planctomycetes	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
CMS3_k127_6491946_0	595460.RRSWK_01582	6.78e-189	598.0	COG0050@1|root,COG0050@2|Bacteria,2IXC2@203682|Planctomycetes	203682|Planctomycetes	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
CMS3_k127_6491946_1	1121468.AUBR01000002_gene709	8.629e-105	357.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,42F8N@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
CMS3_k127_6491946_6	1232410.KI421422_gene1956	2.515e-15	83.0	COG2204@1|root,COG2204@2|Bacteria,1NABF@1224|Proteobacteria,43C0I@68525|delta/epsilon subdivisions,2X7B5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS3_k127_6495661_1	1441629.PCH70_50860	3.34e-17	93.0	COG0739@1|root,COG0739@2|Bacteria,1RIS0@1224|Proteobacteria,1S6KP@1236|Gammaproteobacteria,1Z76E@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,Peptidase_M23
CMS3_k127_6495661_0	1137269.AZWL01000016_gene292	7.842e-56	214.0	COG1680@1|root,COG1680@2|Bacteria,2GJQG@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_6500933_1	926569.ANT_05060	2.182e-23	102.0	COG2115@1|root,COG2115@2|Bacteria,2G688@200795|Chloroflexi	200795|Chloroflexi	G	PFAM Xylose isomerase domain protein TIM barrel	xylA	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
CMS3_k127_6500933_0	452637.Oter_3559	1.634e-133	442.0	COG1070@1|root,COG1070@2|Bacteria,46SI1@74201|Verrucomicrobia,3K7BT@414999|Opitutae	414999|Opitutae	G	FGGY family of carbohydrate kinases, C-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
CMS3_k127_6506500_1	1340493.JNIF01000003_gene3871	7.804e-13	73.0	COG0531@1|root,COG0531@2|Bacteria,3Y2T1@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
CMS3_k127_6506500_0	643867.Ftrac_2464	5.836e-49	199.0	COG1033@1|root,COG1033@2|Bacteria,4NE0M@976|Bacteroidetes,47JQA@768503|Cytophagia	976|Bacteroidetes	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS3_k127_6513170_4	1502852.FG94_03088	1.505e-12	82.0	COG0793@1|root,COG0793@2|Bacteria,1Q13M@1224|Proteobacteria,2W62A@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
CMS3_k127_6513170_1	667014.Thein_0206	2.76e-99	344.0	COG2262@1|root,COG2262@2|Bacteria,2GH9H@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
CMS3_k127_6513170_3	867903.ThesuDRAFT_02082	2.216e-42	160.0	COG1607@1|root,COG1607@2|Bacteria,1V3S2@1239|Firmicutes,24JIT@186801|Clostridia,3WDHI@538999|Clostridiales incertae sedis	186801|Clostridia	I	Thioesterase superfamily	yciA	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS3_k127_6513170_0	344747.PM8797T_06060	1.124e-167	539.0	COG0673@1|root,COG0673@2|Bacteria,2IXJ0@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_6513170_2	756272.Plabr_1949	6.878e-97	338.0	COG1199@1|root,COG1199@2|Bacteria,2IX82@203682|Planctomycetes	203682|Planctomycetes	KL	helicase	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
CMS3_k127_6518744_0	886293.Sinac_1837	3.794e-71	248.0	COG1721@1|root,COG1721@2|Bacteria,2IWV6@203682|Planctomycetes	203682|Planctomycetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_6518744_1	1123242.JH636437_gene6154	7.805e-46	190.0	COG5426@1|root,COG5426@2|Bacteria,2IY0Y@203682|Planctomycetes	203682|Planctomycetes	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
CMS3_k127_6518744_2	518766.Rmar_1340	8.122e-06	57.0	COG2304@1|root,COG2304@2|Bacteria,4NER3@976|Bacteroidetes,1FIZK@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6529779_1	215803.DB30_0394	2.208e-79	274.0	COG0583@1|root,COG0583@2|Bacteria,1PPRQ@1224|Proteobacteria,433YA@68525|delta/epsilon subdivisions,2X421@28221|Deltaproteobacteria,2YY0E@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
CMS3_k127_6529779_0	886293.Sinac_7135	0.0	1220.0	COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,2IXNF@203682|Planctomycetes	203682|Planctomycetes	I	AMP-dependent synthetase and ligase	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase,MFS_1
CMS3_k127_6529779_2	1121013.P873_11880	2.187e-39	154.0	COG1595@1|root,COG1595@2|Bacteria,1RHI0@1224|Proteobacteria,1S454@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6529779_3	1267535.KB906767_gene5125	8.876e-28	130.0	COG1595@1|root,COG1595@2|Bacteria,3Y7Q6@57723|Acidobacteria	57723|Acidobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6532383_0	1040989.AWZU01000008_gene3755	1.676e-91	305.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2UPYY@28211|Alphaproteobacteria,3K2NF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_6532383_1	1040989.AWZU01000008_gene3756	2.077e-45	178.0	COG0642@1|root,COG2205@2|Bacteria,1N5YU@1224|Proteobacteria,2TTXK@28211|Alphaproteobacteria,3K5Y2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_6537045_3	656024.FsymDg_0829	0.0001173	54.0	COG3420@1|root,COG3420@2|Bacteria,2GPK6@201174|Actinobacteria	201174|Actinobacteria	P	TIR domain	-	-	-	ko:K10297	-	-	-	-	ko00000,ko04121	-	-	-	Beta_helix,TIR_2
CMS3_k127_6537045_0	1245471.PCA10_04500	1.483e-145	473.0	COG3930@1|root,COG3930@2|Bacteria,1PYFH@1224|Proteobacteria,1RP1J@1236|Gammaproteobacteria,1YDWQ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	DUF1704	-	-	-	-	-	-	-	-	-	-	-	-	DUF1704
CMS3_k127_6537045_1	1049564.TevJSym_aa00380	3.06e-32	129.0	COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,1S5YT@1236|Gammaproteobacteria,1J66R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
CMS3_k127_6537045_2	172088.AUGA01000001_gene6616	4.509e-09	70.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U182@28211|Alphaproteobacteria,3JUZE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6537045_4	215803.DB30_0540	0.0004784	54.0	COG4932@1|root,COG4932@2|Bacteria,1PEGG@1224|Proteobacteria,43854@68525|delta/epsilon subdivisions,2X3F3@28221|Deltaproteobacteria,2YVTB@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_6554268_1	1340493.JNIF01000004_gene278	5.125e-37	144.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,PD40,PSCyt1,PSCyt2,PSD1,WD40
CMS3_k127_6554268_0	1340493.JNIF01000004_gene277	1.357e-124	412.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_655930_3	479435.Kfla_0996	5.028e-11	72.0	COG0404@1|root,COG0404@2|Bacteria,2I4ER@201174|Actinobacteria,4DX1V@85009|Propionibacteriales	201174|Actinobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
CMS3_k127_655930_2	743721.Psesu_1100	7.797e-19	94.0	COG1959@1|root,COG1959@2|Bacteria,1N0E2@1224|Proteobacteria,1S915@1236|Gammaproteobacteria,1X6CG@135614|Xanthomonadales	135614|Xanthomonadales	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS3_k127_655930_0	1382359.JIAL01000001_gene821	1.94e-172	550.0	COG1104@1|root,COG1104@2|Bacteria,3Y3CG@57723|Acidobacteria,2JI55@204432|Acidobacteriia	204432|Acidobacteriia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS3_k127_655930_1	864051.BurJ1DRAFT_3627	2.104e-63	220.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2VQ2I@28216|Betaproteobacteria,1KKKM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
CMS3_k127_6563093_2	344747.PM8797T_29927	3.188e-29	136.0	COG1196@1|root,COG1196@2|Bacteria,2IZ1V@203682|Planctomycetes	203682|Planctomycetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6563093_0	886293.Sinac_3980	1.331e-74	280.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,2IYCE@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
CMS3_k127_6563093_1	575540.Isop_3542	2.916e-42	171.0	COG1572@1|root,COG2304@1|root,COG1572@2|Bacteria,COG2304@2|Bacteria,2J513@203682|Planctomycetes	203682|Planctomycetes	G	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
CMS3_k127_6565050_2	945713.IALB_0893	1.407e-80	279.0	COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria	2|Bacteria	C	formate dehydrogenase (NAD+) activity	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
CMS3_k127_6565050_0	1382306.JNIM01000001_gene3467	3.181e-143	467.0	COG1894@1|root,COG1894@2|Bacteria,2G5W1@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
CMS3_k127_6565050_3	1168067.JAGP01000001_gene1393	6.163e-29	123.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,460R3@72273|Thiotrichales	72273|Thiotrichales	C	NADH dehydrogenase	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS3_k127_6565050_1	243231.GSU0341	1.023e-134	445.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00333,ko:K13378,ko:K13380	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
CMS3_k127_6565050_4	944479.JQLX01000016_gene358	3.059e-17	83.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42NAR@68525|delta/epsilon subdivisions,2WQB1@28221|Deltaproteobacteria,2M6PV@213113|Desulfurellales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3353	Complex1_30kDa
CMS3_k127_6567286_0	1121091.AUMP01000001_gene135	4.473e-138	461.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,4H9T4@91061|Bacilli	91061|Bacilli	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
CMS3_k127_6567286_1	756272.Plabr_0514	9.177e-117	392.0	COG0766@1|root,COG0766@2|Bacteria,2IWRI@203682|Planctomycetes	203682|Planctomycetes	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
CMS3_k127_656742_1	404380.Gbem_1532	1.517e-44	178.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,43TK2@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
CMS3_k127_656742_2	237368.SCABRO_03873	7.79e-17	92.0	COG1360@1|root,COG1360@2|Bacteria,2IZSF@203682|Planctomycetes	203682|Planctomycetes	N	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
CMS3_k127_656742_0	525903.Taci_1113	3.706e-73	262.0	COG0480@1|root,COG0480@2|Bacteria,3TA2B@508458|Synergistetes	508458|Synergistetes	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS3_k127_6580521_3	1056820.KB900641_gene572	2.217e-29	121.0	COG1853@1|root,COG1853@2|Bacteria,1MUPP@1224|Proteobacteria,1RR4T@1236|Gammaproteobacteria,2PPWF@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
CMS3_k127_6580521_1	314278.NB231_00260	8.806e-145	465.0	KOG2165@1|root,2Z911@2|Bacteria,1N8JM@1224|Proteobacteria,1RR9Z@1236|Gammaproteobacteria,1WWIT@135613|Chromatiales	135613|Chromatiales	S	ubiquitin protein ligase binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6580521_0	472759.Nhal_3586	2.783e-310	979.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1X0IX@135613|Chromatiales	135613|Chromatiales	S	PFAM peptidase S15	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS3_k127_6580521_2	105559.Nwat_0871	1.238e-95	320.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,1SKJ8@1236|Gammaproteobacteria,1X0FH@135613|Chromatiales	135613|Chromatiales	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
CMS3_k127_6580698_0	595460.RRSWK_01932	1.308e-125	418.0	2DU8X@1|root,33PEA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6589000_0	1303518.CCALI_00783	4.488e-80	283.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_6589000_2	1303518.CCALI_00781	2.998e-47	181.0	COG1477@1|root,COG1477@2|Bacteria	2|Bacteria	H	protein flavinylation	apbE_1	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
CMS3_k127_6589000_1	234267.Acid_0683	4.461e-61	224.0	COG0673@1|root,COG0673@2|Bacteria,3Y6VS@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_6598137_2	425104.Ssed_1747	2.729e-152	499.0	COG0366@1|root,COG1409@1|root,COG0366@2|Bacteria,COG1409@2|Bacteria,1PKTM@1224|Proteobacteria,1RWFT@1236|Gammaproteobacteria,2QDDA@267890|Shewanellaceae	1236|Gammaproteobacteria	G	Bacterial Ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Metallophos,Pur_ac_phosph_N
CMS3_k127_6598137_6	323259.Mhun_2441	1.505e-14	87.0	COG3291@1|root,arCOG02527@1|root,arCOG03606@1|root,arCOG06738@1|root,arCOG02510@2157|Archaea,arCOG02527@2157|Archaea,arCOG03606@2157|Archaea,arCOG06738@2157|Archaea	2157|Archaea	O	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	DUF3821,PKD,Peptidase_S8
CMS3_k127_6598137_5	794903.OPIT5_22910	1.294e-22	108.0	COG0705@1|root,COG0705@2|Bacteria	2|Bacteria	S	proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS3_k127_6598137_4	1526927.Plano_2923	4.888e-55	200.0	COG3340@1|root,COG3340@2|Bacteria,1TRBA@1239|Firmicutes,4HB19@91061|Bacilli,26EDR@186818|Planococcaceae	91061|Bacilli	E	Belongs to the peptidase S51 family	ygaJ	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564	3.4.13.21	ko:K05995	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
CMS3_k127_6598137_3	344747.PM8797T_08939	3.942e-79	272.0	COG0432@1|root,COG0432@2|Bacteria,2IZ7Q@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CMS3_k127_6598137_7	290397.Adeh_3290	1.134e-09	69.0	COG4313@1|root,COG4313@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
CMS3_k127_6598137_8	1521187.JPIM01000041_gene563	3.198e-07	63.0	2DM58@1|root,31S4C@2|Bacteria,2GBK4@200795|Chloroflexi,376UX@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6598137_1	1185876.BN8_06071	4.115e-175	585.0	COG3119@1|root,COG3119@2|Bacteria,4NGVK@976|Bacteroidetes,47K11@768503|Cytophagia	976|Bacteroidetes	P	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_6598137_0	1121859.KB890739_gene2782	1.926e-175	565.0	COG2010@1|root,COG2010@2|Bacteria,4NFP6@976|Bacteroidetes,47JRP@768503|Cytophagia	976|Bacteroidetes	C	Protein of unknown function (DUF1549)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,PSCyt1,PSCyt2,PSD1
CMS3_k127_6601585_0	1041146.ATZB01000024_gene2535	7.492e-17	88.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2U4F6@28211|Alphaproteobacteria,4BCVF@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
CMS3_k127_6602234_0	998674.ATTE01000001_gene3243	1.231e-75	271.0	COG1373@1|root,COG1373@2|Bacteria,1MWDX@1224|Proteobacteria,1RYD6@1236|Gammaproteobacteria,460VV@72273|Thiotrichales	72273|Thiotrichales	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS3_k127_6602234_2	1227352.C173_14790	5.321e-23	109.0	COG5586@1|root,COG5586@2|Bacteria,1UY9K@1239|Firmicutes,4HRXB@91061|Bacilli,272WY@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6602234_1	1122138.AQUZ01000065_gene4275	5.641e-68	242.0	COG3440@1|root,COG3440@2|Bacteria	2|Bacteria	V	regulation of methylation-dependent chromatin silencing	-	-	-	ko:K07454	-	-	-	-	ko00000	-	-	-	HNH_2
CMS3_k127_6602234_3	1123501.KB902298_gene3655	2.231e-05	55.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
CMS3_k127_6602272_0	1120797.KB908263_gene248	1.614e-05	58.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2IBPU@201174|Actinobacteria,2346Y@1762|Mycobacteriaceae	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,GAF_3,GGDEF,Guanylate_cyc,HATPase_c,HisKA,HisKA_3,Pkinase
CMS3_k127_6604384_1	192952.MM_3146	1.377e-05	57.0	COG0457@1|root,arCOG03038@2157|Archaea,2Y2TF@28890|Euryarchaeota,2NA8R@224756|Methanomicrobia	2157|Archaea	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_10,TPR_12,TPR_16,TPR_2,TPR_8
CMS3_k127_6604384_0	1123242.JH636434_gene3520	1.573e-135	439.0	COG1473@1|root,COG1473@2|Bacteria,2IX7P@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_6605037_2	861299.J421_1250	1.25e-37	162.0	COG3324@1|root,COG3324@2|Bacteria,1ZU3H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
CMS3_k127_6605037_1	889378.Spiaf_1632	3.769e-129	423.0	COG0126@1|root,COG0126@2|Bacteria,2J68Y@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
CMS3_k127_6605037_0	880073.Calab_3781	2.571e-140	454.0	COG0057@1|root,COG0057@2|Bacteria,2NNPP@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
CMS3_k127_6605037_3	78245.Xaut_3082	2.61e-17	89.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2TRK1@28211|Alphaproteobacteria,3EYHK@335928|Xanthobacteraceae	28211|Alphaproteobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
CMS3_k127_6606954_0	530564.Psta_2519	2.462e-57	218.0	COG3345@1|root,COG3345@2|Bacteria,2J1YM@203682|Planctomycetes	203682|Planctomycetes	G	Pfam:DUF303	-	-	-	-	-	-	-	-	-	-	-	-	SASA
CMS3_k127_6606954_1	1121403.AUCV01000068_gene2206	2.138e-53	200.0	COG3021@1|root,COG3021@2|Bacteria,1MWFK@1224|Proteobacteria,42QIQ@68525|delta/epsilon subdivisions,2WM7F@28221|Deltaproteobacteria,2MJ1M@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS3_k127_6606954_2	1077972.ARGLB_074_00210	6.527e-09	60.0	COG1247@1|root,COG1247@2|Bacteria,2I3CR@201174|Actinobacteria	201174|Actinobacteria	M	GCN5 family acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_6612008_0	595460.RRSWK_01928	2.898e-44	176.0	COG0515@1|root,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,WD40
CMS3_k127_6612008_2	886293.Sinac_7318	2.252e-08	65.0	COG1595@1|root,COG1595@2|Bacteria,2J0K1@203682|Planctomycetes	203682|Planctomycetes	K	TIGRFAM RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	-
CMS3_k127_6612008_1	1128427.KB904821_gene3184	7.437e-21	108.0	COG4249@1|root,COG4249@2|Bacteria,1G2DA@1117|Cyanobacteria,1H881@1150|Oscillatoriales	1117|Cyanobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,Peptidase_C14
CMS3_k127_661364_2	338963.Pcar_1264	5.559e-12	76.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,42NRP@68525|delta/epsilon subdivisions,2X5EK@28221|Deltaproteobacteria,43SA7@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM glycosyl transferase family 9	-	-	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS3_k127_661364_1	247490.KSU1_D0636	4.186e-25	122.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,Methyltransf_11,Methyltransf_23,Methyltransf_25
CMS3_k127_661364_0	867903.ThesuDRAFT_00352	8.405e-183	594.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,3WD0A@538999|Clostridiales incertae sedis	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
CMS3_k127_661364_3	1137799.GZ78_04200	1.555e-11	75.0	COG3137@1|root,COG3137@2|Bacteria,1RHDT@1224|Proteobacteria,1S1K4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
CMS3_k127_6629196_2	886293.Sinac_2761	3.991e-62	241.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IYTQ@203682|Planctomycetes	203682|Planctomycetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16
CMS3_k127_6629196_3	1123024.AUII01000025_gene2162	3.392e-29	121.0	COG1393@1|root,COG1393@2|Bacteria,2IHRP@201174|Actinobacteria,4E4AG@85010|Pseudonocardiales	201174|Actinobacteria	P	Belongs to the ArsC family	arsC	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
CMS3_k127_6629196_0	102129.Lepto7375DRAFT_0219	5.575e-72	257.0	COG1680@1|root,COG1680@2|Bacteria,1G7C0@1117|Cyanobacteria,1HD9W@1150|Oscillatoriales	1117|Cyanobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
CMS3_k127_6629196_1	530564.Psta_3927	1.823e-70	251.0	COG0265@1|root,COG0265@2|Bacteria,2IYZW@203682|Planctomycetes	203682|Planctomycetes	O	typically periplasmic contain C-terminal PDZ domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_6629196_4	1121451.DESAM_23130	0.0002306	49.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2M7YQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the peptidase S1C family	degP	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_6634124_0	1122223.KB890687_gene2597	3.641e-155	506.0	COG2986@1|root,COG2986@2|Bacteria,1WISU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Phenylalanine and histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
CMS3_k127_6634124_4	512565.AMIS_34220	5.049e-30	137.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4D8PV@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_6634124_6	1121920.AUAU01000009_gene1864	2.239e-05	59.0	COG0457@1|root,COG0457@2|Bacteria,3Y5YE@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6634124_2	317619.ANKN01000106_gene3634	5.154e-63	230.0	COG0451@1|root,COG0451@2|Bacteria,1GFA3@1117|Cyanobacteria,1MPC2@1212|Prochloraceae	1117|Cyanobacteria	GM	Male sterility protein	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
CMS3_k127_6634124_5	648885.KB316282_gene1086	1.948e-06	51.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2UCCR@28211|Alphaproteobacteria,1JVD0@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS3_k127_6634124_1	290397.Adeh_0738	4.268e-74	259.0	COG0122@1|root,COG0122@2|Bacteria,1P0FP@1224|Proteobacteria	1224|Proteobacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	-	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
CMS3_k127_6634124_3	243090.RB10165	4.14e-55	211.0	COG1305@1|root,COG3509@1|root,COG1305@2|Bacteria,COG3509@2|Bacteria,2IX6R@203682|Planctomycetes	203682|Planctomycetes	Q	depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1,DLH,Transglut_core
CMS3_k127_6637977_1	575540.Isop_1066	1.602e-20	102.0	COG1197@1|root,COG1197@2|Bacteria,2IWV4@203682|Planctomycetes	203682|Planctomycetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
CMS3_k127_6637977_0	1278309.KB907110_gene3214	4.478e-38	156.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1XHKG@135619|Oceanospirillales	135619|Oceanospirillales	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
CMS3_k127_6643845_0	344747.PM8797T_13478	3.011e-175	565.0	COG2804@1|root,COG2804@2|Bacteria,2IXGK@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
CMS3_k127_6643845_2	278957.ABEA03000180_gene2027	1.649e-116	385.0	COG2805@1|root,COG2805@2|Bacteria,46S5Q@74201|Verrucomicrobia,3K79X@414999|Opitutae	414999|Opitutae	NU	twitching motility protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS3_k127_6643845_1	886293.Sinac_6460	2.614e-165	547.0	COG2804@1|root,COG2804@2|Bacteria,2IXSA@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
CMS3_k127_6643845_4	204669.Acid345_1177	8.472e-24	111.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02650,ko:K02679,ko:K08084	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	N_methyl,Pilin_GH
CMS3_k127_6643845_3	314230.DSM3645_19478	7.062e-73	252.0	COG3119@1|root,COG3119@2|Bacteria,2IX0S@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS3_k127_6657691_0	1313172.YM304_12480	1.675e-08	61.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6660342_1	290397.Adeh_1764	7.168e-39	149.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
CMS3_k127_6660342_0	880073.Calab_3613	9.691e-86	301.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petD	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009512,GO:0009579,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044436,GO:0044459,GO:0044464,GO:0070069,GO:0071944	-	ko:K00412,ko:K02635,ko:K02637,ko:K03887,ko:K03891,ko:K15879	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	-	-	ko00000,ko00001,ko00002,ko00194,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2,Cytochrome_B
CMS3_k127_6660342_2	443143.GM18_0922	8.573e-13	77.0	COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42X9Z@68525|delta/epsilon subdivisions,2WSPW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Rieske 2Fe-2S	cbcV	-	1.10.9.1	ko:K02636	ko00195,ko01100,map00195,map01100	M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske
CMS3_k127_667001_3	1380356.JNIK01000013_gene4099	3.473e-07	63.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator receiver	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_667001_1	575540.Isop_1193	4.722e-55	213.0	COG4191@1|root,COG4191@2|Bacteria,2IXRK@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_667001_0	1379270.AUXF01000001_gene2805	7.198e-57	217.0	COG0644@1|root,COG0644@2|Bacteria,1ZTEM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Glucose inhibited division protein A	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
CMS3_k127_667001_2	756272.Plabr_3364	1.835e-33	148.0	COG1033@1|root,COG1033@2|Bacteria,2J20U@203682|Planctomycetes	203682|Planctomycetes	S	Sterol-sensing domain of SREBP cleavage-activation	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS3_k127_6671038_3	1396141.BATP01000056_gene3278	9.932e-12	76.0	COG0028@1|root,COG3055@1|root,COG3209@1|root,COG4625@1|root,COG4932@1|root,COG0028@2|Bacteria,COG3055@2|Bacteria,COG3209@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	4.1.3.1	ko:K01637,ko:K20276	ko00630,ko01100,ko01110,ko01120,ko01200,ko02024,map00630,map01100,map01110,map01120,map01200,map02024	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	He_PIG,Laminin_G_3,Malectin
CMS3_k127_6671038_1	208444.JNYY01000026_gene4690	5.33e-22	108.0	COG4899@1|root,COG4899@2|Bacteria,2IGN5@201174|Actinobacteria,4E63J@85010|Pseudonocardiales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2199)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2199
CMS3_k127_6671038_2	391625.PPSIR1_20349	1.48e-14	89.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,PDZ_2
CMS3_k127_6671038_4	33876.JNXY01000017_gene7337	7.293e-05	57.0	COG1595@1|root,COG1595@2|Bacteria,2GMJS@201174|Actinobacteria,4DEI0@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6676835_1	338966.Ppro_0014	2.109e-112	378.0	COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,42NBG@68525|delta/epsilon subdivisions,2WKMN@28221|Deltaproteobacteria,43SUB@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemY	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
CMS3_k127_6676835_0	314230.DSM3645_11382	2.476e-228	717.0	COG3119@1|root,COG3119@2|Bacteria,2IX2H@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.14	ko:K01137	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078,M00079	R07808,R07819	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4976,Sulfatase
CMS3_k127_6676835_2	1121019.AUMN01000003_gene1017	8.478e-49	184.0	COG4832@1|root,COG4832@2|Bacteria,2GN4K@201174|Actinobacteria	201174|Actinobacteria	K	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
CMS3_k127_6676835_4	246200.SPO3615	3.529e-12	68.0	COG3449@1|root,COG4977@1|root,COG3449@2|Bacteria,COG4977@2|Bacteria,1QTW6@1224|Proteobacteria,2TXDF@28211|Alphaproteobacteria,4NB28@97050|Ruegeria	28211|Alphaproteobacteria	K	Transcriptional regulator, AraC family	-	-	-	ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18
CMS3_k127_6676835_3	313628.LNTAR_14082	5.019e-33	141.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	5.3.4.1	ko:K01829	-	-	-	-	ko00000,ko01000	-	-	-	Thioredoxin_7
CMS3_k127_6685434_3	1122603.ATVI01000006_gene524	2.924e-62	227.0	COG2133@1|root,COG3386@1|root,COG2133@2|Bacteria,COG3386@2|Bacteria,1R2KP@1224|Proteobacteria,1T5SI@1236|Gammaproteobacteria,1XB12@135614|Xanthomonadales	2|Bacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
CMS3_k127_6685434_1	349741.Amuc_2100	1.639e-93	325.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase,HMG-CoA_red
CMS3_k127_6685434_2	244447.XP_008320224.1	6.342e-65	231.0	COG3142@1|root,KOG4013@2759|Eukaryota,39V2G@33154|Opisthokonta,3BGM4@33208|Metazoa,3CYKC@33213|Bilateria,486D8@7711|Chordata,4931E@7742|Vertebrata,4A03S@7898|Actinopterygii	33208|Metazoa	P	cutC copper transporter homolog (E. coli)	CUTC	GO:0000003,GO:0000041,GO:0002119,GO:0002164,GO:0003008,GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0007275,GO:0007600,GO:0007610,GO:0008150,GO:0009791,GO:0009987,GO:0010035,GO:0010038,GO:0016043,GO:0018991,GO:0019098,GO:0019233,GO:0022414,GO:0022607,GO:0030001,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032504,GO:0035264,GO:0040007,GO:0040025,GO:0042221,GO:0042592,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046688,GO:0046872,GO:0046914,GO:0048513,GO:0048569,GO:0048589,GO:0048609,GO:0048731,GO:0048856,GO:0048878,GO:0050801,GO:0050877,GO:0050896,GO:0051179,GO:0051234,GO:0051259,GO:0051262,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0071840,GO:0098771	-	ko:K06201	-	-	-	-	ko00000	-	-	-	CutC
CMS3_k127_6685434_4	661478.OP10G_3682	2.067e-41	160.0	COG5553@1|root,COG5553@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CDO_I
CMS3_k127_6685434_0	469371.Tbis_2360	6.884e-281	880.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,4DXNT@85010|Pseudonocardiales	201174|Actinobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
CMS3_k127_668595_0	326297.Sama_1484	6.63e-67	244.0	COG3137@1|root,COG3137@2|Bacteria,1RCKQ@1224|Proteobacteria,1S0GK@1236|Gammaproteobacteria,2QA2B@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
CMS3_k127_668595_5	713587.THITH_02925	0.0008714	46.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1WVZJ@135613|Chromatiales	135613|Chromatiales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
CMS3_k127_668595_1	1382304.JNIL01000001_gene3443	5.393e-18	98.0	COG0476@1|root,COG0476@2|Bacteria,1V9AZ@1239|Firmicutes,4HIYB@91061|Bacilli	91061|Bacilli	H	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
CMS3_k127_668595_3	46429.BV95_01046	8.546e-09	65.0	COG1310@1|root,COG1310@2|Bacteria,1N2RC@1224|Proteobacteria,2UQ9Q@28211|Alphaproteobacteria,2K3FN@204457|Sphingomonadales	204457|Sphingomonadales	S	Prokaryotic homologs of the JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
CMS3_k127_668595_4	756272.Plabr_0980	0.0006288	52.0	COG0745@1|root,COG0745@2|Bacteria	756272.Plabr_0980|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_668595_2	1172562.HCN_1491	8.036e-09	68.0	COG0464@1|root,COG0464@2|Bacteria,1N4ZI@1224|Proteobacteria,42NGJ@68525|delta/epsilon subdivisions,2YMAX@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	ATPase (AAA	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS3_k127_6689730_0	1121033.AUCF01000011_gene1776	1.831e-45	179.0	COG3290@1|root,COG4191@1|root,COG3290@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2JRT4@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS
CMS3_k127_6689730_1	398767.Glov_2650	1.519e-26	117.0	COG3945@1|root,COG3945@2|Bacteria,1N3AR@1224|Proteobacteria,42UWM@68525|delta/epsilon subdivisions,2WQEC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
CMS3_k127_6689730_2	653733.Selin_2060	3.989e-19	92.0	2DN81@1|root,32W0Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6692888_1	1144305.PMI02_02336	4.224e-09	66.0	2DBBT@1|root,2Z8AC@2|Bacteria,1NTYT@1224|Proteobacteria,2UQBW@28211|Alphaproteobacteria,2K43U@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
CMS3_k127_6692888_0	1396418.BATQ01000182_gene898	2.068e-11	67.0	COG2317@1|root,COG2317@2|Bacteria,46TJB@74201|Verrucomicrobia,2IU0U@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Carboxypeptidase Taq (M32) metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M32
CMS3_k127_6693788_0	1123508.JH636442_gene3961	1.224e-179	591.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,2IXFD@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_9,Response_reg
CMS3_k127_6708163_0	1408433.JHXV01000002_gene442	9.571e-122	415.0	COG1520@1|root,COG1520@2|Bacteria,4NHPR@976|Bacteroidetes,1HXXS@117743|Flavobacteriia	976|Bacteroidetes	G	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans
CMS3_k127_6708163_1	1123242.JH636436_gene225	4.534e-32	142.0	COG4219@1|root,COG4219@2|Bacteria,2J24Z@203682|Planctomycetes	203682|Planctomycetes	KT	Antirepressor regulating drug resistance	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
CMS3_k127_6721648_3	1396418.BATQ01000113_gene4640	9.845e-09	66.0	2E0WZ@1|root,32WDX@2|Bacteria,46WD0@74201|Verrucomicrobia,2IUTB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6721648_1	370438.PTH_0657	1.017e-62	226.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,260CR@186807|Peptococcaceae	186801|Clostridia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	ACPS,Carb_kinase,YjeF_N
CMS3_k127_6721648_0	987059.RBXJA2T_15133	2.419e-63	230.0	COG4448@1|root,COG4448@2|Bacteria,1R4NH@1224|Proteobacteria,2VJES@28216|Betaproteobacteria	28216|Betaproteobacteria	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
CMS3_k127_6721648_2	237368.SCABRO_03862	2.2e-30	129.0	COG1259@1|root,COG1259@2|Bacteria,2IZNE@203682|Planctomycetes	203682|Planctomycetes	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
CMS3_k127_6724010_0	215803.DB30_7610	2.029e-21	102.0	COG0823@1|root,COG4932@1|root,COG0823@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,43C2M@68525|delta/epsilon subdivisions,2X7D7@28221|Deltaproteobacteria,2Z3FP@29|Myxococcales	28221|Deltaproteobacteria	MU	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD
CMS3_k127_6743319_3	1499967.BAYZ01000074_gene2112	2.464e-05	57.0	COG1413@1|root,COG1413@2|Bacteria,2NRRZ@2323|unclassified Bacteria	2|Bacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS3_k127_6743319_0	1379698.RBG1_1C00001G0230	2.416e-51	201.0	COG2206@1|root,COG2206@2|Bacteria,2NPP4@2323|unclassified Bacteria	2|Bacteria	T	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS3_k127_6743319_1	1183438.GKIL_3066	4.054e-40	171.0	COG2706@1|root,COG2706@2|Bacteria,1GQSX@1117|Cyanobacteria	1117|Cyanobacteria	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	TIG,VCBS
CMS3_k127_6743319_2	998674.ATTE01000001_gene2467	1.078e-11	73.0	COG2383@1|root,COG2383@2|Bacteria,1MZVW@1224|Proteobacteria,1SAW6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	FUN14 family	-	-	-	-	-	-	-	-	-	-	-	-	FUN14
CMS3_k127_6747667_2	1205680.CAKO01000002_gene2680	1.633e-12	72.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497,ko:K09958	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,Mu-transpos_C,rve,rve_3
CMS3_k127_6747667_4	234267.Acid_1623	8.318e-09	59.0	COG2801@1|root,COG2801@2|Bacteria,3Y821@57723|Acidobacteria	57723|Acidobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
CMS3_k127_6747667_0	251221.35214774	9.57e-100	363.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,TIG,VCBS
CMS3_k127_6747667_3	530564.Psta_3393	4.608e-12	74.0	COG1595@1|root,COG1595@2|Bacteria,2IZXA@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6747667_1	391625.PPSIR1_34607	1.721e-14	79.0	COG0515@1|root,COG0515@2|Bacteria	391625.PPSIR1_34607|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6747970_2	886293.Sinac_1635	7.56e-23	103.0	COG0582@1|root,COG0582@2|Bacteria,2IYXX@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
CMS3_k127_6747970_1	1232410.KI421422_gene2001	5.456e-67	250.0	COG0475@1|root,COG0517@1|root,COG0475@2|Bacteria,COG0517@2|Bacteria,1R9PF@1224|Proteobacteria,42RF1@68525|delta/epsilon subdivisions,2WNZ0@28221|Deltaproteobacteria,43TVC@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Na_H_Exchanger,Usp
CMS3_k127_6747970_0	316067.Geob_1667	4.039e-81	284.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42P4E@68525|delta/epsilon subdivisions,2WN09@28221|Deltaproteobacteria,43SVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
CMS3_k127_6748037_4	292459.STH2677	7.33e-32	134.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6748037_3	446470.Snas_1211	3.657e-37	147.0	COG3963@1|root,COG3963@2|Bacteria,2I93P@201174|Actinobacteria	2|Bacteria	I	Phospholipid N-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21,Methyltransf_25,RrnaAD
CMS3_k127_6748037_5	478801.Ksed_21610	3.47e-13	83.0	COG5650@1|root,COG5650@2|Bacteria,2GJBC@201174|Actinobacteria,1ZW90@145357|Dermacoccaceae	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	ko:K13671	-	-	-	-	ko00000,ko01000,ko01003	-	GT87	-	GT87
CMS3_k127_6748037_1	290397.Adeh_2624	9.178e-73	259.0	COG1216@1|root,COG1216@2|Bacteria,1QX3U@1224|Proteobacteria,42RP8@68525|delta/epsilon subdivisions,2WNF5@28221|Deltaproteobacteria,2Z30X@29|Myxococcales	28221|Deltaproteobacteria	S	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
CMS3_k127_6748037_0	391615.ABSJ01000054_gene1424	6.009e-149	486.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1J4HM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125	GATase_6,GATase_7,Pribosyltran
CMS3_k127_6748037_2	329726.AM1_3810	9.471e-62	226.0	COG0115@1|root,COG0115@2|Bacteria,1G8CI@1117|Cyanobacteria	1117|Cyanobacteria	H	PFAM aminotransferase, class IV	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CMS3_k127_6751286_2	313628.LNTAR_01145	5.328e-58	213.0	COG2131@1|root,COG2131@2|Bacteria	2|Bacteria	F	dCMP deaminase activity	dcdA	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
CMS3_k127_6751286_0	1121011.AUCB01000005_gene2472	9.413e-101	336.0	COG3119@1|root,COG3119@2|Bacteria,4NEM3@976|Bacteroidetes,1HZWB@117743|Flavobacteriia,23G8X@178469|Arenibacter	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,PA14,Sulfatase
CMS3_k127_6751286_1	1122179.KB890420_gene2472	4.639e-59	217.0	COG3119@1|root,COG3119@2|Bacteria,4NEM3@976|Bacteroidetes,1IQ0R@117747|Sphingobacteriia	976|Bacteroidetes	P	PFAM sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS3_k127_6751286_3	1144275.COCOR_03507	0.0009835	51.0	COG3485@1|root,COG4932@1|root,COG3485@2|Bacteria,COG4932@2|Bacteria,1P94X@1224|Proteobacteria,4333Y@68525|delta/epsilon subdivisions,2WYD5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_6751344_0	886293.Sinac_2399	5.645e-41	173.0	COG1408@1|root,COG1408@2|Bacteria,2J015@203682|Planctomycetes	203682|Planctomycetes	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
CMS3_k127_6751344_1	861299.J421_5914	1.41e-07	65.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Metallophos,NACHT,Trypsin_2
CMS3_k127_6756987_0	1121875.KB907553_gene20	6.232e-139	458.0	COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
CMS3_k127_6756987_1	864069.MicloDRAFT_00030900	9.804e-11	72.0	COG2067@1|root,COG2067@2|Bacteria,1MYGU@1224|Proteobacteria,2UB0Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6761361_0	717231.Flexsi_1222	1.25e-145	475.0	COG2804@1|root,COG2804@2|Bacteria,2GEP7@200930|Deferribacteres	200930|Deferribacteres	NU	General secretory system II protein E domain protein	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
CMS3_k127_6761361_1	1232410.KI421416_gene2594	1.208e-94	327.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,43RZ2@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Type II secretion system (T2SS), protein F	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
CMS3_k127_6769211_0	1192034.CAP_8173	5.098e-317	995.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2YUFE@29|Myxococcales	28221|Deltaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
CMS3_k127_6786347_0	1273538.G159_16110	3.211e-41	170.0	COG0737@1|root,COG2755@1|root,COG0737@2|Bacteria,COG2755@2|Bacteria,1TPV2@1239|Firmicutes,4H9VJ@91061|Bacilli,26DFG@186818|Planococcaceae	91061|Bacilli	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K01081,ko:K07004,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,CHB_HEX_C_1,CW_binding_2,LTD,Metallophos,SLH
CMS3_k127_6791035_0	1123508.JH636445_gene6798	1.54e-40	154.0	COG0245@1|root,COG0245@2|Bacteria,2IZNY@203682|Planctomycetes	203682|Planctomycetes	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
CMS3_k127_6791035_2	216142.LT40_00520	1.788e-28	124.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050518,GO:0070567,GO:0071704,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2747,iBWG_1329.BWG_2483,iEC55989_1330.EC55989_3019,iECDH10B_1368.ECDH10B_2915,iECDH1ME8569_1439.ECDH1ME8569_2657,iECIAI1_1343.ECIAI1_2848,iECO103_1326.ECO103_3289,iECO111_1330.ECO111_3471,iECO26_1355.ECO26_3816,iECSE_1348.ECSE_2999,iECW_1372.ECW_m2953,iEKO11_1354.EKO11_1022,iEcDH1_1363.EcDH1_0941,iEcE24377_1341.EcE24377A_3048,iEcHS_1320.EcHS_A2885,iEcolC_1368.EcolC_0965,iJO1366.b2747,iJR904.b2747,iPC815.YPO3361,iSBO_1134.SBO_2773,iSDY_1059.SDY_2946,iSSON_1240.SSON_2895,iSbBS512_1146.SbBS512_E3127,iUMNK88_1353.UMNK88_3422,iWFL_1372.ECW_m2953,iY75_1357.Y75_RS14300	IspD
CMS3_k127_6791035_3	237368.SCABRO_00727	3.085e-23	114.0	COG0817@1|root,COG0817@2|Bacteria,2IZJS@203682|Planctomycetes	203682|Planctomycetes	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
CMS3_k127_6791035_1	1121423.JONT01000006_gene2517	3.078e-38	155.0	COG0455@1|root,COG0455@2|Bacteria,1TRZ5@1239|Firmicutes,24AIN@186801|Clostridia,26151@186807|Peptococcaceae	186801|Clostridia	D	Belongs to the ParA family	flhG	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
CMS3_k127_6792576_1	1552123.EP57_15905	2.124e-06	57.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,4HACY@91061|Bacilli,26J80@186820|Listeriaceae	91061|Bacilli	O	Belongs to the ClpA ClpB family	clpC	GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
CMS3_k127_6792576_0	1170562.Cal6303_4120	4.375e-61	229.0	COG0457@1|root,COG0457@2|Bacteria,1GE9K@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
CMS3_k127_6797098_9	883126.HMPREF9710_04137	2.647e-15	88.0	COG3055@1|root,COG3055@2|Bacteria,1QSB4@1224|Proteobacteria,2W1RC@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,Kelch_6
CMS3_k127_6797098_6	1122609.AUGT01000002_gene4022	6.948e-47	175.0	COG0307@1|root,COG0307@2|Bacteria,2GKC5@201174|Actinobacteria,4DQ6E@85009|Propionibacteriales	201174|Actinobacteria	H	riboflavin synthase, alpha	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
CMS3_k127_6797098_2	1123508.JH636444_gene5187	4.069e-69	243.0	COG0336@1|root,COG0336@2|Bacteria,2IXVH@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
CMS3_k127_6797098_8	65393.PCC7424_1023	7.295e-37	145.0	COG0335@1|root,COG0335@2|Bacteria,1G5QG@1117|Cyanobacteria,3KI0B@43988|Cyanothece	1117|Cyanobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
CMS3_k127_6797098_0	344747.PM8797T_31765	1.327e-103	372.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,2IYCQ@203682|Planctomycetes	203682|Planctomycetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4	-	-	SecD_SecF,Sec_GG
CMS3_k127_6797098_10	1173028.ANKO01000127_gene4144	3.863e-11	76.0	COG2319@1|root,COG2319@2|Bacteria,1GQ9V@1117|Cyanobacteria,1HAG1@1150|Oscillatoriales	1117|Cyanobacteria	S	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH,WD40
CMS3_k127_6797098_5	391038.Bphy_1085	4.854e-51	198.0	28M5B@1|root,2ZAJ4@2|Bacteria,1R7Y9@1224|Proteobacteria,2VSMK@28216|Betaproteobacteria,1K5H6@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6797098_7	439292.Bsel_0444	4.87e-45	173.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS3_k127_6797098_1	1487953.JMKF01000048_gene2039	7.945e-70	247.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_6797098_3	42256.RradSPS_2710	2.732e-63	226.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_6797098_4	1487953.JMKF01000048_gene2040	3.164e-54	196.0	COG1898@1|root,COG1898@2|Bacteria	2|Bacteria	M	dTDP-4-dehydrorhamnose 3,5-epimerase activity	rfbC	-	1.1.1.133,4.2.1.46,5.1.3.13	ko:K00067,ko:K01710,ko:K01790	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R02777,R06513,R06514	RC00182,RC00402,RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
CMS3_k127_6829041_1	1499967.BAYZ01000041_gene2340	0.0002416	44.0	2EH5Q@1|root,33AXM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6829041_0	886293.Sinac_3442	3.579e-05	57.0	COG0526@1|root,COG1470@1|root,COG1595@1|root,COG0526@2|Bacteria,COG1470@2|Bacteria,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	AhpC-TSA,DUF4384,NPCBM_assoc,PEGA,Sigma70_r2,Sigma70_r4_2,Thioredoxin_8
CMS3_k127_6840977_0	1122939.ATUD01000001_gene577	2.148e-149	511.0	COG1520@1|root,COG1520@2|Bacteria,2H3K4@201174|Actinobacteria,4CRJK@84995|Rubrobacteria	84995|Rubrobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6840977_1	357804.Ping_0487	6.493e-56	202.0	COG0655@1|root,COG0655@2|Bacteria,1RKK7@1224|Proteobacteria	1224|Proteobacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS3_k127_6844188_2	502025.Hoch_3311	6.533e-10	72.0	COG0793@1|root,COG0793@2|Bacteria,1QT96@1224|Proteobacteria,437TZ@68525|delta/epsilon subdivisions,2X33H@28221|Deltaproteobacteria,2YU2B@29|Myxococcales	28221|Deltaproteobacteria	MQ	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,PDZ_2
CMS3_k127_6844188_1	344747.PM8797T_01004	2.082e-35	144.0	COG1090@1|root,COG1090@2|Bacteria	2|Bacteria	S	coenzyme binding	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
CMS3_k127_6844188_0	530564.Psta_2567	2.088e-120	402.0	COG3828@1|root,COG3828@2|Bacteria,2IY8Q@203682|Planctomycetes	203682|Planctomycetes	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
CMS3_k127_6847107_0	886293.Sinac_3627	8.204e-58	216.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_8,WD40
CMS3_k127_6847107_1	794846.AJQU01000088_gene4716	1.723e-06	57.0	COG1595@1|root,COG1595@2|Bacteria,1RKMN@1224|Proteobacteria,2U9GS@28211|Alphaproteobacteria,4BDTH@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6853059_0	572265.HDEF_0187	3.163e-10	63.0	COG0241@1|root,COG0572@1|root,COG1208@1|root,COG0241@2|Bacteria,COG0572@2|Bacteria,COG1208@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria,283FX@191675|unclassified Enterobacteriaceae	1236|Gammaproteobacteria	E	D,D-heptose 1,7-bisphosphate phosphatase	gmhB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033692,GO:0034200,GO:0034637,GO:0034645,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046872,GO:0046914,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iB21_1397.B21_00198,iEC55989_1330.EC55989_0198,iECBD_1354.ECBD_3418,iECB_1328.ECB_00199,iECD_1391.ECD_00199,iECIAI1_1343.ECIAI1_0202,iECO103_1326.ECO103_0200,iECSE_1348.ECSE_0202,iETEC_1333.ETEC_0196,iEcHS_1320.EcHS_A0204,iEcolC_1368.EcolC_3459	HAD_2,Hydrolase_like
CMS3_k127_6855444_2	497964.CfE428DRAFT_0896	4.162e-09	66.0	COG1595@1|root,COG1595@2|Bacteria,46V3R@74201|Verrucomicrobia	74201|Verrucomicrobia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6855444_1	314230.DSM3645_11631	9.313e-33	134.0	COG1595@1|root,COG1595@2|Bacteria,2J3FS@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS3_k127_6855444_0	502025.Hoch_1711	1.413e-36	155.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria	1224|Proteobacteria	M	PFAM Formylglycine-generating sulfatase enzyme	-	-	2.7.11.1	ko:K11912,ko:K20333	ko02024,ko02025,ko03070,map02024,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase,PEGA,Pkinase,TIR_2
CMS3_k127_6856000_0	1123508.JH636452_gene7057	0.0	1148.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,2J2J0@203682|Planctomycetes	203682|Planctomycetes	S	Vault protein inter-alpha-trypsin domain	-	-	-	-	-	-	-	-	-	-	-	-	VIT,VWA_3
CMS3_k127_6867467_0	1121935.AQXX01000045_gene4606	1.267e-62	242.0	COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,1RQ0T@1236|Gammaproteobacteria,1XH9Y@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_6867467_2	1286632.P278_13810	1.449e-20	102.0	COG0824@1|root,COG0824@2|Bacteria,4NQGW@976|Bacteroidetes,1I2UT@117743|Flavobacteriia	976|Bacteroidetes	S	thioesterase	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
CMS3_k127_6867467_3	682795.AciX8_0672	3.334e-07	61.0	2DTIS@1|root,33KJ1@2|Bacteria,3Y5U4@57723|Acidobacteria,2JN6V@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6867467_1	429009.Adeg_0956	8.427e-49	193.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,42ER1@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS3_k127_6878618_1	357808.RoseRS_4080	5.19e-71	263.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_21,Methyltransf_23,Methyltransf_31
CMS3_k127_6878618_0	1167006.UWK_01989	6.102e-111	368.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42NYX@68525|delta/epsilon subdivisions,2WJV8@28221|Deltaproteobacteria,2MIJX@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
CMS3_k127_6885488_0	344747.PM8797T_25576	0.0	1105.0	COG0841@1|root,COG0841@2|Bacteria,2IY0K@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS3_k127_6885488_1	644801.Psest_3902	2.306e-16	82.0	COG1499@1|root,COG1499@2|Bacteria,1RD49@1224|Proteobacteria,1T15U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	ribosomal large subunit export from nucleus	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6890439_0	525909.Afer_1020	0.0	1469.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4CNGZ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS3_k127_6890439_1	1304275.C41B8_18181	6.662e-181	580.0	COG0437@1|root,COG3301@1|root,COG0437@2|Bacteria,COG3301@2|Bacteria,1MU1B@1224|Proteobacteria,1SYJH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_3,Fer4_7
CMS3_k127_6890439_2	1123371.ATXH01000007_gene530	3.577e-05	55.0	COG0739@1|root,COG4413@1|root,COG0739@2|Bacteria,COG4413@2|Bacteria,2GHAY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	EM	Urea transporter	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,UT
CMS3_k127_6903390_2	1163409.UUA_00340	4.109e-21	107.0	COG1538@1|root,COG1538@2|Bacteria,1QCDW@1224|Proteobacteria,1S4D7@1236|Gammaproteobacteria,1X5VY@135614|Xanthomonadales	135614|Xanthomonadales	MU	COG1538 Outer membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS3_k127_6903390_4	314292.VAS14_22232	3.215e-11	76.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1XT7F@135623|Vibrionales	135623|Vibrionales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
CMS3_k127_6903390_0	1089550.ATTH01000001_gene2034	5.461e-280	894.0	COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,1FJVI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	czcA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
CMS3_k127_6903390_1	2903.EOD12694	4.023e-33	142.0	2EMF1@1|root,2SR43@2759|Eukaryota	2903.EOD12694|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6903390_3	1357399.HMPREF2087_00380	2.489e-12	71.0	COG2921@1|root,COG2921@2|Bacteria	2|Bacteria	S	Belongs to the UPF0250 family	ybeD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K09158	-	-	-	-	ko00000	-	-	-	DUF493
CMS3_k127_6921181_0	671143.DAMO_0255	5.82e-52	203.0	COG0438@1|root,COG3754@1|root,COG4372@1|root,COG5610@1|root,COG0438@2|Bacteria,COG3754@2|Bacteria,COG4372@2|Bacteria,COG5610@2|Bacteria,2NR6D@2323|unclassified Bacteria	2|Bacteria	M	Evidence 5 No homology to any previously reported sequences	sll1424	-	2.1.1.80,3.1.1.61	ko:K01991,ko:K02557,ko:K07161,ko:K07484,ko:K13924,ko:K20444,ko:K21471	ko02020,ko02026,ko02030,ko02040,map02020,map02026,map02030,map02040	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01005,ko01011,ko02000,ko02022,ko02035	1.A.30.1,1.B.18,4.D.1.3	GT2,GT4	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,DUF3084,LZ_Tnp_IS66,zf-IS66
CMS3_k127_6921181_1	521674.Plim_2781	2.008e-11	76.0	COG4099@1|root,COG4099@2|Bacteria,2IYJQ@203682|Planctomycetes	203682|Planctomycetes	S	allantoin biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS3_k127_6925954_4	222534.KB893670_gene3874	4.047e-32	128.0	COG0451@1|root,COG0451@2|Bacteria,2GNYX@201174|Actinobacteria,4ETSW@85013|Frankiales	201174|Actinobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS3_k127_6925954_1	1499967.BAYZ01000104_gene3698	3.034e-164	527.0	COG2227@1|root,COG2227@2|Bacteria,2NQQ9@2323|unclassified Bacteria	2|Bacteria	H	Putative zinc binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
CMS3_k127_6925954_2	489825.LYNGBM3L_36810	2.179e-135	441.0	COG2227@1|root,COG2227@2|Bacteria,1G1XD@1117|Cyanobacteria,1HA3C@1150|Oscillatoriales	1117|Cyanobacteria	H	C-methyltransferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_14,Methyltransf_23
CMS3_k127_6925954_3	313612.L8106_11737	5.489e-89	320.0	COG2227@1|root,COG2227@2|Bacteria,1G2VI@1117|Cyanobacteria,1H7RG@1150|Oscillatoriales	1117|Cyanobacteria	H	C-methyltransferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
CMS3_k127_6925954_0	1211777.BN77_p10815	5.116e-201	630.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
CMS3_k127_6927627_1	671143.DAMO_1656	1.194e-08	66.0	COG4591@1|root,COG4591@2|Bacteria,2NP18@2323|unclassified Bacteria	2|Bacteria	M	ABC-type transport system involved in lipoprotein release permease component	lolC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778	-	ko:K02004,ko:K09808	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125	-	-	FtsX,MacB_PCD
CMS3_k127_6927627_0	1449126.JQKL01000057_gene2241	4.461e-148	484.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,267P2@186813|unclassified Clostridiales	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
CMS3_k127_6929316_2	448385.sce1143	1.243e-10	70.0	COG3210@1|root,COG3210@2|Bacteria,1QW1H@1224|Proteobacteria	1224|Proteobacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6929316_0	867845.KI911784_gene2719	8.49e-73	271.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PKD,SBBP
CMS3_k127_6929316_3	243090.RB6034	0.0002384	53.0	COG1595@1|root,COG1595@2|Bacteria,2J02A@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_6929316_1	649754.HMPREF0281_00879	4.46e-47	181.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,22JIY@1653|Corynebacteriaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS3_k127_6931648_0	530564.Psta_3106	1.307e-89	301.0	COG3485@1|root,COG3485@2|Bacteria,2IYK6@203682|Planctomycetes	203682|Planctomycetes	Q	PFAM intradiol ring-cleavage dioxygenase	-	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
CMS3_k127_6931648_1	1150864.MILUP08_45175	6.71e-12	78.0	COG5650@1|root,COG5650@2|Bacteria,2GJBC@201174|Actinobacteria,4DAYR@85008|Micromonosporales	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	ko:K13671	-	-	-	-	ko00000,ko01000,ko01003	-	GT87	-	GT87
CMS3_k127_693721_6	1121920.AUAU01000004_gene908	3.263e-11	74.0	COG1100@1|root,COG1100@2|Bacteria	2|Bacteria	S	GTP binding	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	DUF697,MMR_HSR1
CMS3_k127_693721_3	102125.Xen7305DRAFT_00047600	1.328e-78	278.0	COG0666@1|root,COG0666@2|Bacteria,1G52C@1117|Cyanobacteria	1117|Cyanobacteria	S	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
CMS3_k127_693721_5	1120983.KB894577_gene3521	3.346e-26	119.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS3_k127_693721_1	1123368.AUIS01000023_gene925	6.269e-123	404.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	antiporter	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS3_k127_693721_7	270374.MELB17_15307	7.631e-08	61.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RZ1Y@1236|Gammaproteobacteria,466WI@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS3_k127_693721_9	1117647.M5M_10750	1.176e-06	56.0	COG2819@1|root,COG2819@2|Bacteria,1RAB4@1224|Proteobacteria,1S2JK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	hydrolase of the alpha beta superfamily	Z012_06880	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS3_k127_693721_0	448385.sce5150	2.361e-163	533.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,42MQD@68525|delta/epsilon subdivisions,2WJJP@28221|Deltaproteobacteria,2YY08@29|Myxococcales	28221|Deltaproteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily)	ychM	-	4.2.1.1	ko:K01673,ko:K03321	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000,ko02000	2.A.53.3	-	-	Pro_CA,STAS,STAS_2,Sulfate_transp
CMS3_k127_693721_4	1210884.HG799473_gene14994	7.082e-32	130.0	COG0640@1|root,COG0640@2|Bacteria,2J3D0@203682|Planctomycetes	203682|Planctomycetes	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
CMS3_k127_693721_2	240015.ACP_1207	3.207e-110	367.0	COG4063@1|root,COG4063@2|Bacteria	2|Bacteria	H	Domain of unknown function (DUF4346)	-	-	2.1.1.86	ko:K00577	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4346,MtrA
CMS3_k127_6937680_6	1380390.JIAT01000009_gene1257	6.82e-18	87.0	COG0491@1|root,COG0491@2|Bacteria,2GJ7I@201174|Actinobacteria,4CQ3N@84995|Rubrobacteria	84995|Rubrobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_6937680_3	314254.OA2633_11520	1.883e-73	262.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2TSWI@28211|Alphaproteobacteria,43W94@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	Putative RNA methylase family UPF0020	rlmL	-	2.1.1.173,2.1.1.264	ko:K07444,ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	THUMP,UPF0020
CMS3_k127_6937680_1	756272.Plabr_4485	1.841e-112	372.0	COG3622@1|root,COG3622@2|Bacteria,2J4Z5@203682|Planctomycetes	203682|Planctomycetes	G	PFAM Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS3_k127_6937680_5	1120965.AUBV01000007_gene2463	1.968e-21	101.0	COG3182@1|root,COG3182@2|Bacteria,4NIXJ@976|Bacteroidetes,47PX8@768503|Cytophagia	976|Bacteroidetes	S	PepSY-associated TM region	-	-	-	ko:K09939	-	-	-	-	ko00000	-	-	-	PepSY_TM
CMS3_k127_6937680_4	314230.DSM3645_26589	1.048e-57	226.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_16,TPR_2,TPR_8
CMS3_k127_6937680_8	1206725.BAFU01000061_gene472	3.91e-08	66.0	COG1595@1|root,COG1595@2|Bacteria,2GM8T@201174|Actinobacteria,4FYJ2@85025|Nocardiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigD	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_6937680_0	344747.PM8797T_25491	6.577e-148	484.0	COG3653@1|root,COG3653@2|Bacteria,2IXWQ@203682|Planctomycetes	203682|Planctomycetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS3_k127_6937680_2	1907.SGLAU_30675	6.748e-89	301.0	COG3828@1|root,COG3828@2|Bacteria,2GJW0@201174|Actinobacteria	201174|Actinobacteria	M	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	CBM_6,Glyco_hydro_99,ThuA
CMS3_k127_6948473_0	1184267.A11Q_895	1.027e-300	943.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2MSPP@213481|Bdellovibrionales,2WJSH@28221|Deltaproteobacteria	213481|Bdellovibrionales	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS3_k127_6948473_1	1238182.C882_4356	9.652e-17	91.0	COG1600@1|root,COG1600@2|Bacteria,1R9XX@1224|Proteobacteria,2UA5Q@28211|Alphaproteobacteria,2JSJ4@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1145 Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6949084_0	644966.Tmar_1356	2.305e-53	205.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,3WDS9@538999|Clostridiales incertae sedis	186801|Clostridia	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07668,ko:K07775	ko02020,map02020	M00458,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_6949084_1	196162.Noca_2855	1.081e-33	138.0	COG5002@1|root,COG5002@2|Bacteria,2I3ZY@201174|Actinobacteria,4DTJ3@85009|Propionibacteriales	201174|Actinobacteria	T	PAS fold	-	-	2.7.13.3	ko:K18350	ko01502,ko02020,map01502,map02020	M00652,M00657	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	GAF,HATPase_c,HisKA,PAS_4
CMS3_k127_6954267_1	497964.CfE428DRAFT_6648	3.262e-176	576.0	COG3119@1|root,COG3119@2|Bacteria,46UMG@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
CMS3_k127_6954267_2	75379.Tint_1988	1.238e-81	279.0	COG2362@1|root,COG2362@2|Bacteria,1QH4F@1224|Proteobacteria,2VJ5K@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM peptidase M55 D-aminopeptidase	dppA1a	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
CMS3_k127_6954267_0	1232410.KI421412_gene169	3.056e-208	653.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NQ1@68525|delta/epsilon subdivisions,2X5KW@28221|Deltaproteobacteria,43SYA@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
CMS3_k127_6961076_2	748247.AZKH_3598	2.151e-29	128.0	COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,2VUX2@28216|Betaproteobacteria,2KWYP@206389|Rhodocyclales	206389|Rhodocyclales	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_6961076_0	656024.FsymDg_1688	5.353e-104	350.0	COG0381@1|root,COG0381@2|Bacteria,2GJWS@201174|Actinobacteria,4ESVX@85013|Frankiales	201174|Actinobacteria	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	rffE	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
CMS3_k127_6961076_1	489825.LYNGBM3L_67660	1.453e-30	126.0	COG0438@1|root,COG0457@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,1G3JN@1117|Cyanobacteria,1H700@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_6961383_8	1192034.CAP_2839	5.905e-06	58.0	COG0308@1|root,COG0308@2|Bacteria,1NJK3@1224|Proteobacteria,42Y4Q@68525|delta/epsilon subdivisions,2WTET@28221|Deltaproteobacteria,2YVW2@29|Myxococcales	28221|Deltaproteobacteria	E	aminopeptidase N	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2
CMS3_k127_6961383_3	96561.Dole_2971	4.514e-35	144.0	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,42UW6@68525|delta/epsilon subdivisions,2WQ4A@28221|Deltaproteobacteria,2MJDS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
CMS3_k127_6961383_1	537013.CLOSTMETH_00818	2.303e-55	205.0	COG0253@1|root,COG0253@2|Bacteria,1UKZQ@1239|Firmicutes,25G82@186801|Clostridia,3WSST@541000|Ruminococcaceae	186801|Clostridia	E	Diaminopimelate epimerase	-	-	-	-	-	-	-	-	-	-	-	-	DAP_epimerase
CMS3_k127_6961383_9	1122604.JONR01000014_gene237	3.525e-05	56.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S876@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6961383_5	589865.DaAHT2_0005	2.894e-14	86.0	COG0457@1|root,COG0501@1|root,COG0457@2|Bacteria,COG0501@2|Bacteria,1R5A7@1224|Proteobacteria,42MP6@68525|delta/epsilon subdivisions,2WK92@28221|Deltaproteobacteria,2MIHI@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_11,TPR_17
CMS3_k127_6961383_4	1340493.JNIF01000003_gene3119	1.618e-17	98.0	COG0657@1|root,COG1520@1|root,COG0657@2|Bacteria,COG1520@2|Bacteria,3Y44Z@57723|Acidobacteria	57723|Acidobacteria	I	Alpha beta hydrolase fold-3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,PQQ_2
CMS3_k127_6961383_6	1210884.HG799464_gene10585	8.296e-08	66.0	COG1520@1|root,COG1520@2|Bacteria,2IXF0@203682|Planctomycetes	203682|Planctomycetes	S	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_6961383_0	886293.Sinac_3984	6.036e-89	307.0	COG2373@1|root,COG2373@2|Bacteria,2IYJD@203682|Planctomycetes	203682|Planctomycetes	S	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
CMS3_k127_6961383_2	1123242.JH636435_gene1214	4.393e-35	148.0	COG2304@1|root,COG2304@2|Bacteria,2IYRG@203682|Planctomycetes	203682|Planctomycetes	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
CMS3_k127_6964216_0	243231.GSU1320	1.028e-113	382.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43TS4@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K02481,ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_6964216_1	398767.Glov_1695	1.025e-18	87.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WJKV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	2.7.13.3	ko:K02482,ko:K10819	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9
CMS3_k127_6964357_0	1499967.BAYZ01000064_gene6007	1.677e-120	412.0	COG0457@1|root,COG1729@1|root,COG2373@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894,ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	A2M,A2M_N,A2M_N_2,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8,Thiol-ester_cl,VWA_2
CMS3_k127_6970708_3	886293.Sinac_6888	6.912e-64	229.0	COG0109@1|root,COG0109@2|Bacteria,2IYUU@203682|Planctomycetes	203682|Planctomycetes	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
CMS3_k127_6970708_5	926566.Terro_0293	1.313e-34	139.0	COG1845@1|root,COG1845@2|Bacteria,3Y414@57723|Acidobacteria,2JI50@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
CMS3_k127_6970708_11	886293.Sinac_6890	1.43e-05	51.0	2EJIC@1|root,33D99@2|Bacteria,2J1A5@203682|Planctomycetes	203682|Planctomycetes	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
CMS3_k127_6970708_1	530564.Psta_2924	2.235e-91	310.0	COG1131@1|root,COG1131@2|Bacteria,2IYFJ@203682|Planctomycetes	203682|Planctomycetes	V	COG1131 ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_6970708_2	1382359.JIAL01000001_gene2623	1.913e-67	240.0	COG0842@1|root,COG0842@2|Bacteria,3Y2S4@57723|Acidobacteria,2JISC@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CMS3_k127_6970708_7	926549.KI421517_gene1896	3.11e-32	134.0	COG1999@1|root,COG1999@2|Bacteria,4NFH2@976|Bacteroidetes,47XQN@768503|Cytophagia	976|Bacteroidetes	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
CMS3_k127_6970708_4	313628.LNTAR_20388	9.501e-36	142.0	COG2322@1|root,COG2322@2|Bacteria	2|Bacteria	S	membrane	yozB	-	-	ko:K07152,ko:K08976	-	-	-	-	ko00000,ko03029	-	-	-	DUF420
CMS3_k127_6970708_9	234267.Acid_5454	5.933e-17	92.0	COG0511@1|root,COG1413@1|root,COG0511@2|Bacteria,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	pcmV	-	2.3.1.12	ko:K00627,ko:K02160,ko:K07402	ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00307,M00376	R00209,R00742,R02569	RC00004,RC00040,RC00367,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,MDMPI_C,MDMPI_N,XdhC_C,XdhC_CoxI
CMS3_k127_6970708_6	234267.Acid_3885	1.291e-32	141.0	COG1245@1|root,COG1245@2|Bacteria	2|Bacteria	C	4Fe-4S binding domain	rnfB	-	1.8.99.2	ko:K00395,ko:K02572,ko:K03616	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FeS,Fer4,Fer4_4,Fer4_7
CMS3_k127_6970708_8	522306.CAP2UW1_1842	5.901e-17	93.0	COG0500@1|root,COG2226@2|Bacteria,1Q73B@1224|Proteobacteria,2W6KU@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_6970708_10	1123508.JH636443_gene4943	1.887e-06	59.0	2FAXA@1|root,34345@2|Bacteria,2J3IQ@203682|Planctomycetes	203682|Planctomycetes	S	Lipopolysaccharide kinase (Kdo/WaaP) family	-	-	-	-	-	-	-	-	-	-	-	-	Kdo
CMS3_k127_6970708_0	1499967.BAYZ01000074_gene2085	3.463e-130	426.0	COG1816@1|root,COG1816@2|Bacteria,2NQUP@2323|unclassified Bacteria	2|Bacteria	F	Adenosine/AMP deaminase	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
CMS3_k127_6974540_2	203119.Cthe_0261	6.819e-47	176.0	COG0546@1|root,COG0546@2|Bacteria,1V6UK@1239|Firmicutes,24KPU@186801|Clostridia,3WII6@541000|Ruminococcaceae	186801|Clostridia	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS3_k127_6974540_4	1206741.BAFX01000049_gene2180	2.057e-39	157.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4FUZ4@85025|Nocardiaceae	201174|Actinobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
CMS3_k127_6974540_3	237368.SCABRO_03331	8.993e-44	182.0	COG0706@1|root,COG0706@2|Bacteria,2IYA0@203682|Planctomycetes	203682|Planctomycetes	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,PDZ_2,YidC_periplas
CMS3_k127_6974540_0	886293.Sinac_0799	4.436e-76	264.0	COG0639@1|root,COG0639@2|Bacteria,2IYH6@203682|Planctomycetes	203682|Planctomycetes	T	COG0639 Diadenosine tetraphosphatase and related	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
CMS3_k127_6974540_5	1123278.KB893561_gene3190	1.259e-06	60.0	COG0760@1|root,COG2885@1|root,COG0760@2|Bacteria,COG2885@2|Bacteria,4NGIR@976|Bacteroidetes,47K78@768503|Cytophagia	976|Bacteroidetes	O	peptidyl-prolyl isomerase	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3
CMS3_k127_6974540_1	1210884.HG799465_gene11519	4.067e-62	225.0	COG0324@1|root,COG0324@2|Bacteria,2IYY6@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
CMS3_k127_6975628_4	1121935.AQXX01000139_gene2976	3.339e-55	206.0	COG1704@1|root,COG1704@2|Bacteria,1NS0H@1224|Proteobacteria,1SKFZ@1236|Gammaproteobacteria,1XNZK@135619|Oceanospirillales	135619|Oceanospirillales	S	E3 Ubiquitin ligase	-	-	-	-	-	-	-	-	-	-	-	-	GIDE,LemA
CMS3_k127_6975628_5	1041147.AUFB01000001_gene4305	1.421e-54	202.0	COG3221@1|root,COG3221@2|Bacteria,1RDG5@1224|Proteobacteria,2U8X7@28211|Alphaproteobacteria,4B7PJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	COG3221 ABC-type phosphate phosphonate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Phosphonate-bd
CMS3_k127_6975628_0	1121441.AUCX01000017_gene2004	1.217e-160	537.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2M7U6@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K01338,ko:K04076,ko:K04770	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Lon_C
CMS3_k127_6975628_3	313596.RB2501_09100	6.24e-64	234.0	COG5285@1|root,COG5285@2|Bacteria,4NHQ6@976|Bacteroidetes,1HZVH@117743|Flavobacteriia	976|Bacteroidetes	Q	PFAM Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
CMS3_k127_6975628_2	502025.Hoch_5543	5.396e-76	258.0	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,42ZS1@68525|delta/epsilon subdivisions,2WV25@28221|Deltaproteobacteria,2YV5R@29|Myxococcales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
CMS3_k127_6975628_1	215803.DB30_8712	2.143e-91	317.0	COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,42WNA@68525|delta/epsilon subdivisions,2WRKM@28221|Deltaproteobacteria,2YUJ7@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
CMS3_k127_6990172_0	314230.DSM3645_21282	4.09e-94	330.0	COG3064@1|root,COG3064@2|Bacteria,2IWVN@203682|Planctomycetes	203682|Planctomycetes	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	PPC
CMS3_k127_6990172_1	575540.Isop_3524	8.151e-80	285.0	COG5492@1|root,COG5492@2|Bacteria,2IXP9@203682|Planctomycetes	203682|Planctomycetes	N	Protein of unknown function (DUF1549)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt2,PSD1
CMS3_k127_699595_12	1144275.COCOR_03507	1.45e-06	62.0	COG3485@1|root,COG4932@1|root,COG3485@2|Bacteria,COG4932@2|Bacteria,1P94X@1224|Proteobacteria,4333Y@68525|delta/epsilon subdivisions,2WYD5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_699595_5	448385.sce2299	1.233e-119	404.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria,2YWKI@29|Myxococcales	28221|Deltaproteobacteria	H	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
CMS3_k127_699595_9	314278.NB231_04620	3.764e-27	115.0	COG1396@1|root,COG1396@2|Bacteria,1PF62@1224|Proteobacteria,1STU2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_699595_2	1283300.ATXB01000001_gene1800	8.184e-169	542.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria,1XDMT@135618|Methylococcales	1236|Gammaproteobacteria	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_699595_6	378806.STAUR_2892	5.924e-80	278.0	COG0665@1|root,COG0665@2|Bacteria,1NCJX@1224|Proteobacteria,431XD@68525|delta/epsilon subdivisions,2WWSZ@28221|Deltaproteobacteria,2YUQQ@29|Myxococcales	28221|Deltaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.3.3	ko:K00273	ko00260,ko00311,ko00330,ko00472,ko01100,ko01130,ko04146,map00260,map00311,map00330,map00472,map01100,map01130,map04146	-	R00366,R02457,R02894,R02923,R04221,R07400	RC00006,RC00018,RC00135	ko00000,ko00001,ko01000	-	-	-	DAO
CMS3_k127_699595_7	234267.Acid_4388	2.232e-48	183.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	-	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
CMS3_k127_699595_3	234267.Acid_4387	5.088e-138	445.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
CMS3_k127_699595_4	234267.Acid_4386	3.085e-127	413.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
CMS3_k127_699595_0	234267.Acid_4385	1.263e-237	771.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,PA14
CMS3_k127_699595_11	234267.Acid_4384	2.984e-24	113.0	COG3794@1|root,COG3794@2|Bacteria,3Y4A0@57723|Acidobacteria	57723|Acidobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_699595_8	530564.Psta_2930	4.772e-44	172.0	COG1622@1|root,COG1622@2|Bacteria,2IZBI@203682|Planctomycetes	203682|Planctomycetes	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
CMS3_k127_699595_1	575540.Isop_0869	1.301e-224	714.0	COG0843@1|root,COG0843@2|Bacteria,2IXCQ@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
CMS3_k127_699595_10	518766.Rmar_1786	9.779e-27	122.0	COG1612@1|root,COG1612@2|Bacteria,4PEIM@976|Bacteroidetes,1FJ6F@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	Cytochrome oxidase assembly protein	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
CMS3_k127_7000584_0	1121948.AUAC01000002_gene1024	4.256e-64	228.0	COG0778@1|root,COG0778@2|Bacteria,1MY39@1224|Proteobacteria,2TTZC@28211|Alphaproteobacteria,43X6X@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS3_k127_7001805_1	1167006.UWK_01998	1.176e-61	221.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,42QJ7@68525|delta/epsilon subdivisions,2WPQE@28221|Deltaproteobacteria,2MKG7@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_7001805_2	1167006.UWK_01998	5.061e-46	183.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,42QJ7@68525|delta/epsilon subdivisions,2WPQE@28221|Deltaproteobacteria,2MKG7@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_7001805_0	266117.Rxyl_3109	2.457e-62	240.0	COG1216@1|root,COG1216@2|Bacteria,2HTM1@201174|Actinobacteria,4CPU8@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_7001805_3	243231.GSU3324	0.0001577	50.0	COG1974@1|root,COG1974@2|Bacteria	2|Bacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31,Peptidase_S24
CMS3_k127_7005492_2	1232683.ADIMK_0810	9.552e-17	84.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,465WZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Mechanosensitive ion channel	kefA	-	-	ko:K05802,ko:K22051	-	-	-	-	ko00000,ko02000	1.A.23.1.1,1.A.23.1.2,1.A.23.1.3	-	-	MS_channel,MscS_TM,MscS_porin
CMS3_k127_7005492_0	1089551.KE386572_gene1405	2.928e-95	323.0	COG0667@1|root,COG0667@2|Bacteria,1MWGQ@1224|Proteobacteria,2TUJ8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldo keto reductase	-	-	1.1.1.122	ko:K00064	ko00051,ko00053,ko01100,ko01110,ko01120,map00051,map00053,map01100,map01110,map01120	M00114	R07675,R08926	RC00066,RC00161	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldo_ket_red
CMS3_k127_7005492_5	211114.JOEF01000020_gene685	7.335e-12	77.0	COG2340@1|root,COG2340@2|Bacteria,2GM57@201174|Actinobacteria,4E5J3@85010|Pseudonocardiales	201174|Actinobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
CMS3_k127_7005492_4	1095767.CAHD01000112_gene12	8.67e-15	82.0	COG4978@1|root,COG4978@2|Bacteria,2IQMV@201174|Actinobacteria,4F2Q6@85016|Cellulomonadaceae	201174|Actinobacteria	KT	Bacterial transcription activator, effector binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
CMS3_k127_7005492_1	290397.Adeh_0163	1.585e-22	109.0	COG1451@1|root,COG1451@2|Bacteria	2|Bacteria	S	Protein of unknown function DUF45	CP_0175	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45,SprT-like
CMS3_k127_7005492_3	497964.CfE428DRAFT_0809	4.758e-16	79.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,46TYP@74201|Verrucomicrobia	74201|Verrucomicrobia	CG	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7006709_1	448385.sce7168	1.646e-59	212.0	COG4636@1|root,COG4636@2|Bacteria	2|Bacteria	D	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
CMS3_k127_7006709_5	497964.CfE428DRAFT_6042	6.49e-14	86.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,46TYQ@74201|Verrucomicrobia	2|Bacteria	CG	Cytochrome c	-	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Cytochrom_C,GSDH,HEAT_2,HEAT_PBS,S1,ThuA
CMS3_k127_7006709_0	886293.Sinac_7247	1.459e-119	396.0	COG0673@1|root,COG0673@2|Bacteria,2IX34@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_7006709_3	204773.HEAR1601	5.978e-36	145.0	COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,2W2IK@28216|Betaproteobacteria,478R5@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
CMS3_k127_7006709_2	710686.Mycsm_03877	1.827e-36	152.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,2338E@1762|Mycobacteriaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS3_k127_7006709_4	575540.Isop_1830	9.738e-18	89.0	COG1061@1|root,COG1061@2|Bacteria,2IYCX@203682|Planctomycetes	203682|Planctomycetes	L	Helicase conserved C-terminal domain	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
CMS3_k127_7016560_0	1038867.AXAY01000006_gene3838	0.0003165	54.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,3JRSC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_10,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_7,TPR_8
CMS3_k127_7018754_3	552811.Dehly_1315	3.085e-32	129.0	COG2008@1|root,COG2008@2|Bacteria,2G5XG@200795|Chloroflexi,34CXV@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Beta-eliminating lyase	gly1	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
CMS3_k127_7018754_0	204669.Acid345_2243	2.763e-157	507.0	COG0436@1|root,COG0436@2|Bacteria,3Y3DG@57723|Acidobacteria,2JMAM@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS3_k127_7018754_1	1142394.PSMK_17430	7.721e-78	274.0	COG0420@1|root,COG0420@2|Bacteria	2|Bacteria	L	3'-5' exonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
CMS3_k127_7018754_2	1142394.PSMK_17420	9.181e-75	284.0	COG0419@1|root,COG0419@2|Bacteria	2|Bacteria	L	ATPase involved in DNA repair	sbcC	-	-	-	-	-	-	-	-	-	-	-	AAA_23,AAA_27
CMS3_k127_7036681_0	121225.PHUM122250-PA	8.243e-26	124.0	COG0457@1|root,KOG1124@2759|Eukaryota,38CY4@33154|Opisthokonta,3BAFG@33208|Metazoa,3CV6Z@33213|Bilateria,41W55@6656|Arthropoda,3SG5T@50557|Insecta,3E8F3@33342|Paraneoptera	33208|Metazoa	S	Domain of unknown function (DUF1736)	TMTC3	GO:0001763,GO:0002009,GO:0003401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006950,GO:0007275,GO:0008150,GO:0009653,GO:0009791,GO:0009887,GO:0009888,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010468,GO:0010604,GO:0012505,GO:0019222,GO:0030154,GO:0030162,GO:0030323,GO:0030324,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0033554,GO:0034976,GO:0035239,GO:0035295,GO:0040007,GO:0042176,GO:0042692,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0045732,GO:0045862,GO:0048286,GO:0048468,GO:0048513,GO:0048518,GO:0048522,GO:0048589,GO:0048729,GO:0048731,GO:0048747,GO:0048754,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051146,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051716,GO:0055001,GO:0055002,GO:0060255,GO:0060425,GO:0060429,GO:0060441,GO:0060447,GO:0060541,GO:0060560,GO:0060562,GO:0060602,GO:0061061,GO:0061136,GO:0061138,GO:0065007,GO:0080090,GO:1901800,GO:1903050,GO:1903052,GO:1903362,GO:1903364	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
CMS3_k127_7047436_6	1192034.CAP_3243	2.597e-21	103.0	COG4219@1|root,COG4219@2|Bacteria,1PEGJ@1224|Proteobacteria,438JW@68525|delta/epsilon subdivisions,2X3UI@28221|Deltaproteobacteria,2YX4Y@29|Myxococcales	28221|Deltaproteobacteria	DKT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
CMS3_k127_7047436_2	1254432.SCE1572_39675	1.579e-114	376.0	COG4422@1|root,COG4422@2|Bacteria,1MXQI@1224|Proteobacteria,42NZ6@68525|delta/epsilon subdivisions,2WKPZ@28221|Deltaproteobacteria,2YWD6@29|Myxococcales	28221|Deltaproteobacteria	S	Pfam:Gp37_Gp68	-	-	-	-	-	-	-	-	-	-	-	-	DUF5131
CMS3_k127_7047436_3	1242864.D187_004101	5.198e-72	257.0	COG4422@1|root,COG4422@2|Bacteria	2|Bacteria	F	Protein of unknown function (DUF5131)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5131
CMS3_k127_7047436_1	1254432.SCE1572_15930	3.301e-116	401.0	COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria	1224|Proteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HTH_8,Sigma54_activat
CMS3_k127_7047436_5	1254432.SCE1572_23055	3.288e-56	214.0	COG1355@1|root,COG1355@2|Bacteria,1N5H1@1224|Proteobacteria,42TIN@68525|delta/epsilon subdivisions,2WR24@28221|Deltaproteobacteria,2Z1BF@29|Myxococcales	28221|Deltaproteobacteria	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
CMS3_k127_7047436_7	316058.RPB_1539	6.714e-05	55.0	COG0438@1|root,COG0438@2|Bacteria,1MWYH@1224|Proteobacteria,2UBKP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
CMS3_k127_7047436_4	521674.Plim_3643	1.737e-56	211.0	COG1082@1|root,COG1082@2|Bacteria,2IZ9I@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS3_k127_7047436_0	1254432.SCE1572_32230	3.003e-123	403.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,42U5B@68525|delta/epsilon subdivisions,2WQVN@28221|Deltaproteobacteria,2YWFF@29|Myxococcales	28221|Deltaproteobacteria	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS3_k127_7051799_0	502025.Hoch_5286	4.937e-101	335.0	COG0031@1|root,COG0517@1|root,COG0031@2|Bacteria,COG0517@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,2YWSI@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
CMS3_k127_7051799_2	592029.DDD_1875	0.0007928	51.0	COG1409@1|root,COG2866@1|root,COG3209@1|root,COG3386@1|root,COG1409@2|Bacteria,COG2866@2|Bacteria,COG3209@2|Bacteria,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cu-binding_MopE,DUF5011,Laminin_G_3,Lyase_8,Lyase_catalyt,SprB,VCBS,fn3
CMS3_k127_7051799_1	234267.Acid_0555	2.243e-26	115.0	COG1682@1|root,COG1682@2|Bacteria	2|Bacteria	GM	macromolecule localization	-	-	-	ko:K01992,ko:K09690	ko02010,map02010	M00250,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103	-	-	ABC2_membrane
CMS3_k127_7052039_3	1140.Synpcc7942_0702	1.365e-32	131.0	COG1912@1|root,COG1912@2|Bacteria,1G1B1@1117|Cyanobacteria,1GYAI@1129|Synechococcus	1117|Cyanobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
CMS3_k127_7052039_5	1293054.HSACCH_00450	5.406e-13	72.0	COG2128@1|root,COG2128@2|Bacteria,1UVG3@1239|Firmicutes	1239|Firmicutes	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_7052039_6	292414.TM1040_1739	3.186e-10	66.0	COG2128@1|root,COG2128@2|Bacteria,1PQ1G@1224|Proteobacteria,2U17A@28211|Alphaproteobacteria,4NBJF@97050|Ruegeria	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_7052039_2	502025.Hoch_5425	6.173e-68	237.0	COG2316@1|root,COG2316@2|Bacteria,1RA50@1224|Proteobacteria,42QZZ@68525|delta/epsilon subdivisions,2WMUN@28221|Deltaproteobacteria,2Z0YN@29|Myxococcales	28221|Deltaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS3_k127_7052039_0	1463921.JODF01000036_gene1138	2.309e-93	322.0	COG2234@1|root,COG2234@2|Bacteria,2I9YF@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS3_k127_7052039_4	1183438.GKIL_3263	2.849e-16	93.0	COG1470@1|root,COG3391@1|root,COG1470@2|Bacteria,COG3391@2|Bacteria,1G0EB@1117|Cyanobacteria	1117|Cyanobacteria	DZ	PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,DUF4347,He_PIG,HemolysinCabind,PPC,VCBS
CMS3_k127_7052039_1	1131269.AQVV01000013_gene1726	4.206e-92	325.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS3_k127_7062639_3	349741.Amuc_0696	7.627e-07	63.0	COG1657@1|root,COG1657@2|Bacteria,46XAC@74201|Verrucomicrobia,2IV6H@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7062639_0	1121012.AUKX01000016_gene3001	1.091e-151	502.0	COG0673@1|root,COG0673@2|Bacteria,4NGTW@976|Bacteroidetes,1I164@117743|Flavobacteriia,23IAD@178469|Arenibacter	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_7062639_1	886293.Sinac_3874	9.083e-41	162.0	COG0526@1|root,COG4796@1|root,COG0526@2|Bacteria,COG4796@2|Bacteria,2J147@203682|Planctomycetes	203682|Planctomycetes	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_7069299_1	886293.Sinac_3002	9.082e-14	85.0	29VFX@1|root,30GX8@2|Bacteria,2IZ6B@203682|Planctomycetes	203682|Planctomycetes	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
CMS3_k127_7069299_0	344747.PM8797T_03109	7.786e-80	282.0	COG3659@1|root,COG3659@2|Bacteria,2IXZU@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the OprB family	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
CMS3_k127_7075181_0	530564.Psta_3017	1.158e-140	457.0	COG1053@1|root,COG1053@2|Bacteria,2IXHQ@203682|Planctomycetes	203682|Planctomycetes	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
CMS3_k127_7075181_1	1121011.AUCB01000006_gene1017	7.736e-122	410.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1I0X7@117743|Flavobacteriia,23FWQ@178469|Arenibacter	976|Bacteroidetes	E	Sodium:solute symporter family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS3_k127_7077024_1	215803.DB30_2809	2.609e-24	105.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2YU20@29|Myxococcales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
CMS3_k127_7077024_3	1116232.AHBF01000137_gene1841	4.571e-18	96.0	COG0730@1|root,COG0730@2|Bacteria,2I8CY@201174|Actinobacteria	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS3_k127_7077024_2	472759.Nhal_1735	5.244e-21	102.0	COG1131@1|root,COG1131@2|Bacteria,1QW3E@1224|Proteobacteria,1T2RB@1236|Gammaproteobacteria,1X2NQ@135613|Chromatiales	135613|Chromatiales	V	ABC transporter	-	-	3.6.3.27	ko:K06021	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran
CMS3_k127_7077024_0	933262.AXAM01000006_gene1839	1.613e-57	211.0	COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,42Q0J@68525|delta/epsilon subdivisions,2WNYQ@28221|Deltaproteobacteria,2MJB9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterised protein family (UPF0014)	-	-	-	ko:K02069	-	M00211	-	-	ko00000,ko00002,ko02000	9.B.25.1	-	-	UPF0014
CMS3_k127_7077024_4	243090.RB10120	4.571e-05	52.0	COG1595@1|root,COG1595@2|Bacteria,2J06I@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_7089798_0	1265505.ATUG01000001_gene4766	8.441e-189	619.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WIUM@28221|Deltaproteobacteria,2MI28@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_7089798_1	378806.STAUR_1605	6.003e-08	66.0	COG0457@1|root,COG3307@1|root,COG0457@2|Bacteria,COG3307@2|Bacteria,1N225@1224|Proteobacteria,42QDQ@68525|delta/epsilon subdivisions,2WM6B@28221|Deltaproteobacteria,2YVDU@29|Myxococcales	28221|Deltaproteobacteria	M	O-antigen ligase like membrane protein	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	TPR_14,TPR_16,TPR_8,Wzy_C
CMS3_k127_7094648_1	448385.sce2398	1.151e-44	185.0	COG5164@1|root,COG5164@2|Bacteria,1N2FU@1224|Proteobacteria,42WNM@68525|delta/epsilon subdivisions,2WRNC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Collagen triple helix repeat (20 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen
CMS3_k127_7094648_2	999549.KI421513_gene2344	5.728e-39	166.0	2E9PG@1|root,333VW@2|Bacteria,1NEU7@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7094648_0	756272.Plabr_1607	1.538e-187	599.0	COG3119@1|root,COG3119@2|Bacteria,2J2PQ@203682|Planctomycetes	203682|Planctomycetes	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CMS3_k127_7095281_3	1120973.AQXL01000132_gene2216	4.503e-36	156.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,4HADT@91061|Bacilli	91061|Bacilli	KT	Transcriptional regulator	pspF	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_9,Sigma54_activat
CMS3_k127_7095281_2	1120973.AQXL01000110_gene1005	2.833e-73	262.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,4HAEE@91061|Bacilli,2780T@186823|Alicyclobacillaceae	91061|Bacilli	E	Aminotransferase class-V	nifZ	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS3_k127_7095281_1	358681.BBR47_41140	1.029e-93	332.0	COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,4HAV9@91061|Bacilli,26SZ1@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
CMS3_k127_7095281_4	1123371.ATXH01000001_gene1278	8.978e-28	119.0	COG0071@1|root,COG0071@2|Bacteria,2GHTW@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS3_k127_7095281_0	861299.J421_3809	7.088e-203	647.0	COG0058@1|root,COG0058@2|Bacteria,1ZSZ3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
CMS3_k127_7095353_2	880073.Calab_3278	3.594e-65	239.0	COG3049@1|root,COG3049@2|Bacteria	2|Bacteria	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
CMS3_k127_7095353_0	886293.Sinac_7483	1.085e-94	351.0	COG0515@1|root,COG0515@2|Bacteria,2IYTQ@203682|Planctomycetes	203682|Planctomycetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16
CMS3_k127_7095353_3	886293.Sinac_7484	1.07e-45	176.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_7095353_1	926569.ANT_08110	8.224e-70	248.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	2.7.1.188,2.7.1.2,2.7.1.214,2.7.1.60,5.1.3.9	ko:K00845,ko:K13967,ko:K19979,ko:K20433	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko00525,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map00525,map01100,map01110,map01120,map01130,map01200	M00001,M00549,M00814,M00815	R00299,R01600,R01786,R02087,R02705,R11185,R11234	RC00002,RC00017,RC00290	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
CMS3_k127_7100870_1	111780.Sta7437_4145	1.765e-25	109.0	COG1359@1|root,COG1359@2|Bacteria,1GB91@1117|Cyanobacteria,3VKT8@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
CMS3_k127_7100870_0	1120950.KB892707_gene5004	3.442e-137	448.0	COG1362@1|root,COG1362@2|Bacteria,2GKW4@201174|Actinobacteria,4DPTA@85009|Propionibacteriales	201174|Actinobacteria	E	Aminopeptidase I zinc metalloprotease (M18)	apeB	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
CMS3_k127_7100870_2	530564.Psta_4423	8.972e-20	104.0	COG3345@1|root,COG3345@2|Bacteria,2IYVN@203682|Planctomycetes	203682|Planctomycetes	G	Carbohydrate esterase, sialic acid-specific acetylesterase	-	-	-	-	-	-	-	-	-	-	-	-	SASA
CMS3_k127_7100870_3	1500894.JQNN01000001_gene1017	3.498e-15	79.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2VIVJ@28216|Betaproteobacteria,4737G@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Beta-eliminating lyase	-	-	-	-	-	-	-	-	-	-	-	-	Beta_elim_lyase
CMS3_k127_7103947_0	886293.Sinac_3371	2.651e-255	809.0	COG2010@1|root,COG2010@2|Bacteria,2IYIY@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
CMS3_k127_7103947_1	1210884.HG799465_gene11901	1.84e-88	299.0	COG3119@1|root,COG3119@2|Bacteria,2IXXZ@203682|Planctomycetes	203682|Planctomycetes	P	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_7105857_1	471854.Dfer_0412	6.749e-113	391.0	COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes,47MBT@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
CMS3_k127_7105857_0	1121918.ARWE01000001_gene3150	6.556e-226	717.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,42P5Y@68525|delta/epsilon subdivisions,2WJEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
CMS3_k127_7105857_2	388467.A19Y_0672	2.759e-89	314.0	COG2304@1|root,COG2304@2|Bacteria,1G2HT@1117|Cyanobacteria,1H70B@1150|Oscillatoriales	1117|Cyanobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
CMS3_k127_7105973_4	338963.Pcar_2495	1.922e-53	194.0	COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,42MZG@68525|delta/epsilon subdivisions,2WKZ3@28221|Deltaproteobacteria,43UBA@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
CMS3_k127_7105973_1	1242864.D187_000932	3.23e-98	338.0	COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria	1224|Proteobacteria	G	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
CMS3_k127_7105973_0	530564.Psta_1668	2.6e-123	415.0	COG1520@1|root,COG1520@2|Bacteria,2IY7A@203682|Planctomycetes	203682|Planctomycetes	S	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS3_k127_7105973_2	1156937.MFUM_990023	1.543e-67	238.0	COG1073@1|root,COG1073@2|Bacteria,46V25@74201|Verrucomicrobia,37G63@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Serine hydrolase (FSH1)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
CMS3_k127_7105973_6	1215092.PA6_006_00570	0.0001301	52.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,1RN1W@1236|Gammaproteobacteria,1YD2G@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
CMS3_k127_7105973_5	472759.Nhal_1453	9.856e-10	69.0	2EB0T@1|root,3351P@2|Bacteria,1NCHM@1224|Proteobacteria,1SJ6Z@1236|Gammaproteobacteria,1X1WX@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7105973_3	530564.Psta_4503	3.403e-67	237.0	COG0635@1|root,COG0635@2|Bacteria,2IY84@203682|Planctomycetes	203682|Planctomycetes	H	COG0635 Coproporphyrinogen III oxidase and related Fe-S	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS3_k127_710711_1	402777.KB235904_gene3532	1.914e-54	201.0	COG1011@1|root,COG1011@2|Bacteria,1G4JI@1117|Cyanobacteria,1H8VT@1150|Oscillatoriales	1117|Cyanobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS3_k127_710711_0	498761.HM1_2802	5.783e-173	559.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia	186801|Clostridia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
CMS3_k127_710711_2	1254432.SCE1572_40010	1.141e-09	64.0	COG0642@1|root,COG0784@1|root,COG2770@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X83K@28221|Deltaproteobacteria,2YUDP@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Response_reg,dCache_1
CMS3_k127_710711_3	1382306.JNIM01000001_gene3423	1.474e-05	58.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	1382306.JNIM01000001_gene3423|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7107687_0	861360.AARI_15720	1.621e-18	87.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,1W7U9@1268|Micrococcaceae	201174|Actinobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapX	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
CMS3_k127_7113102_1	595460.RRSWK_06070	2.966e-143	469.0	COG0673@1|root,COG0673@2|Bacteria,2IXJ0@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_7113102_0	1122605.KB893646_gene217	2.331e-186	595.0	COG1649@1|root,COG1649@2|Bacteria,4NFKQ@976|Bacteroidetes,1IQ50@117747|Sphingobacteriia	976|Bacteroidetes	S	Glycosyl hydrolase-like 10	yngK	-	-	-	-	-	-	-	-	-	-	-	GHL10
CMS3_k127_7113968_2	247490.KSU1_B0403	2.377e-24	108.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	cpoB	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	TPR_16,TPR_6,TPR_8,TolA_bind_tri,YfiO
CMS3_k127_7113968_3	326427.Cagg_0206	1.058e-16	91.0	COG1721@1|root,COG1721@2|Bacteria,2GACI@200795|Chloroflexi,375AS@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_7113968_1	1206741.BAFX01000139_gene2596	9.067e-80	275.0	COG0454@1|root,COG0456@2|Bacteria,2I9PD@201174|Actinobacteria,4G0GW@85025|Nocardiaceae	201174|Actinobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_6
CMS3_k127_7113968_0	1156937.MFUM_110014	1.648e-142	462.0	COG0465@1|root,COG0465@2|Bacteria,46SB7@74201|Verrucomicrobia,37G3T@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
CMS3_k127_7116314_0	1122179.KB890434_gene874	7.966e-61	229.0	COG4733@1|root,COG5276@1|root,COG4733@2|Bacteria,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1IYS6@117747|Sphingobacteriia	976|Bacteroidetes	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3
CMS3_k127_7116314_1	1210884.HG799465_gene11731	2.602e-06	49.0	COG1393@1|root,COG1393@2|Bacteria,2J19I@203682|Planctomycetes	203682|Planctomycetes	P	Belongs to the ArsC family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_712276_0	1411123.JQNH01000001_gene1616	4.468e-230	728.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CMS3_k127_712276_2	383372.Rcas_0002	9.574e-134	438.0	COG5621@1|root,COG5621@2|Bacteria,2G6EI@200795|Chloroflexi,374YJ@32061|Chloroflexia	32061|Chloroflexia	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
CMS3_k127_712276_1	1278073.MYSTI_07376	4.853e-183	608.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,42MX2@68525|delta/epsilon subdivisions,2WIUV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_712276_4	316274.Haur_1468	1.869e-69	243.0	COG1136@1|root,COG1136@2|Bacteria,2G8HT@200795|Chloroflexi,375FM@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_712276_3	1142394.PSMK_15140	1.984e-94	336.0	COG0043@1|root,COG0043@2|Bacteria,2IYCA@203682|Planctomycetes	203682|Planctomycetes	H	COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
CMS3_k127_7124029_1	1210884.HG799470_gene14441	3.8e-31	135.0	COG0515@1|root,COG0515@2|Bacteria,2IWY8@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_7124029_4	530564.Psta_2501	4.313e-08	64.0	COG1595@1|root,COG1595@2|Bacteria,2J02A@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_7124029_3	1297742.A176_05231	3.963e-08	62.0	29921@1|root,2ZW5I@2|Bacteria,1RE74@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7124029_0	379066.GAU_0292	7.53e-74	257.0	COG1131@1|root,COG1131@2|Bacteria,1ZT45@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_7124029_2	452637.Oter_1501	1.437e-09	71.0	29YN3@1|root,30KHK@2|Bacteria	2|Bacteria	S	Putative ABC exporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_export
CMS3_k127_7127015_0	1907.SGLAU_00210	1.588e-68	248.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	-	-	4.2.3.152,4.2.3.4	ko:K01735,ko:K19969	ko00400,ko00525,ko01100,ko01110,ko01130,ko01230,map00400,map00525,map01100,map01110,map01130,map01230	M00022,M00814,M00815	R03083,R10937	RC00847,RC03308	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
CMS3_k127_7127015_1	671143.DAMO_0255	2.785e-64	239.0	COG0438@1|root,COG3754@1|root,COG4372@1|root,COG5610@1|root,COG0438@2|Bacteria,COG3754@2|Bacteria,COG4372@2|Bacteria,COG5610@2|Bacteria,2NR6D@2323|unclassified Bacteria	2|Bacteria	M	Evidence 5 No homology to any previously reported sequences	sll1424	-	2.1.1.80,3.1.1.61	ko:K01991,ko:K02557,ko:K07161,ko:K07484,ko:K13924,ko:K20444,ko:K21471	ko02020,ko02026,ko02030,ko02040,map02020,map02026,map02030,map02040	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01005,ko01011,ko02000,ko02022,ko02035	1.A.30.1,1.B.18,4.D.1.3	GT2,GT4	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,DUF3084,LZ_Tnp_IS66,zf-IS66
CMS3_k127_7129360_4	700015.Corgl_1591	9.838e-05	53.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4CUMC@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
CMS3_k127_7129360_2	529709.PYCH_12980	3.144e-31	132.0	COG0424@1|root,arCOG05007@2157|Archaea,2XZIF@28890|Euryarchaeota,243F5@183968|Thermococci	183968|Thermococci	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
CMS3_k127_7129360_3	572480.Arnit_0172	8.58e-26	108.0	COG0254@1|root,COG0254@2|Bacteria,1PT0H@1224|Proteobacteria,42V2Z@68525|delta/epsilon subdivisions,2YQ19@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
CMS3_k127_7129360_0	665571.STHERM_c19280	8.257e-105	351.0	COG0216@1|root,COG0216@2|Bacteria,2J5KY@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CMS3_k127_7129360_1	246197.MXAN_4908	4.101e-49	186.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WNH0@28221|Deltaproteobacteria,2YVC9@29|Myxococcales	28221|Deltaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
CMS3_k127_7132671_0	1415778.JQMM01000001_gene316	4.431e-97	327.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RPUE@1236|Gammaproteobacteria,1J825@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	HflC and HflK could encode or regulate a protease	-	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
CMS3_k127_7132671_1	398580.Dshi_1814	4.276e-09	70.0	COG2931@1|root,COG2931@2|Bacteria,1NV5X@1224|Proteobacteria,2URVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7134443_2	880073.Calab_2688	2.323e-25	115.0	COG1143@1|root,COG1143@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338,ko:K03615,ko:K05580	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
CMS3_k127_7134443_3	1191523.MROS_2373	2.993e-23	108.0	COG0839@1|root,COG0839@2|Bacteria	2|Bacteria	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
CMS3_k127_7134443_4	290318.Cvib_1086	7.718e-17	87.0	COG0713@1|root,COG0713@2|Bacteria,1FE6D@1090|Chlorobi	1090|Chlorobi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
CMS3_k127_7134443_1	404380.Gbem_3915	1.865e-130	442.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,43TW3@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
CMS3_k127_7134443_0	1191523.MROS_2370	1.025e-161	525.0	COG1008@1|root,COG1008@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
CMS3_k127_713609_0	1303518.CCALI_01855	3.296e-132	435.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750	FAD-oxidase_C,FAD_binding_4
CMS3_k127_713609_1	314264.ROS217_22132	1.309e-16	88.0	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,46Q1X@74030|Roseovarius	28211|Alphaproteobacteria	H	COG3572 Gamma-glutamylcysteine synthetase	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
CMS3_k127_7151508_0	1122182.KB903833_gene5429	2.092e-126	437.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,2I9U6@201174|Actinobacteria,4DH83@85008|Micromonosporales	201174|Actinobacteria	O	Proprotein convertase P-domain	-	-	-	-	-	-	-	-	-	-	-	-	P_proprotein,Peptidase_S8
CMS3_k127_7160857_0	1379270.AUXF01000004_gene3079	8.137e-82	280.0	COG1024@1|root,COG1024@2|Bacteria,1ZT76@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS3_k127_7160857_3	935567.JAES01000026_gene1342	7.065e-43	169.0	COG0463@1|root,COG0463@2|Bacteria,1PVP4@1224|Proteobacteria,1RQUH@1236|Gammaproteobacteria,1X5X0@135614|Xanthomonadales	135614|Xanthomonadales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_7160857_4	237368.SCABRO_03057	2.764e-38	162.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_trans_1_4,Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1
CMS3_k127_7160857_6	646529.Desaci_0603	7.107e-21	106.0	COG4641@1|root,COG4641@2|Bacteria,1V2W1@1239|Firmicutes,24GPM@186801|Clostridia,262M0@186807|Peptococcaceae	186801|Clostridia	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
CMS3_k127_7160857_5	631362.Thi970DRAFT_03915	6.858e-38	156.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RZRG@1236|Gammaproteobacteria,1WVXI@135613|Chromatiales	135613|Chromatiales	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_7160857_2	945713.IALB_1713	9.755e-75	265.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS3_k127_7160857_1	234267.Acid_6208	5.757e-79	280.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,3Y4F0@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C,Cytochrome_B
CMS3_k127_7161503_1	622637.KE124774_gene1876	1.751e-05	58.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,36YC7@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1
CMS3_k127_7161503_0	313606.M23134_07049	2.473e-63	240.0	COG3227@1|root,COG3227@2|Bacteria,4NF8H@976|Bacteroidetes	976|Bacteroidetes	E	Thermolysin metallopeptidase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF5011,Inhibitor_I69,MAM,Peptidase_C10,Peptidase_M14,Peptidase_M43,Reprolysin_4,fn3
CMS3_k127_7169125_0	243090.RB7769	1.413e-145	482.0	COG3119@1|root,COG3119@2|Bacteria,2IXP1@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
CMS3_k127_7169125_2	313589.JNB_15818	1.18e-05	59.0	COG1595@1|root,COG1595@2|Bacteria,2GP9D@201174|Actinobacteria,4FFIW@85021|Intrasporangiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigK	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_7169125_1	285535.JOEY01000095_gene4026	3.17e-14	81.0	COG1595@1|root,COG1595@2|Bacteria,2IKVM@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_7174925_2	314230.DSM3645_10817	0.0001088	51.0	COG0848@1|root,COG0848@2|Bacteria,2J10K@203682|Planctomycetes	203682|Planctomycetes	U	Biopolymer transport protein	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
CMS3_k127_7174925_1	595460.RRSWK_04499	7.383e-05	51.0	COG0848@1|root,COG0848@2|Bacteria,2J0CP@203682|Planctomycetes	203682|Planctomycetes	U	Biopolymer transport protein	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
CMS3_k127_7174925_0	344747.PM8797T_23726	7.213e-32	134.0	COG0811@1|root,COG0811@2|Bacteria,2IZCS@203682|Planctomycetes	203682|Planctomycetes	U	COG0811 Biopolymer transport	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
CMS3_k127_7174925_3	518766.Rmar_1517	0.0001912	53.0	COG0457@1|root,COG1729@1|root,COG4105@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,COG4105@2|Bacteria,4NE4W@976|Bacteroidetes,1FJ24@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Anaphase-promoting complex, cyclosome, subunit 3	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
CMS3_k127_7176552_4	1385515.N791_12160	2.936e-32	126.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1X32R@135614|Xanthomonadales	135614|Xanthomonadales	O	Part of SUF system involved in inserting iron-sulfur clusters into proteins	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
CMS3_k127_7176552_0	1469245.JFBG01000076_gene140	2.749e-255	795.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1WWT1@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
CMS3_k127_7176552_8	204669.Acid345_0125	0.0003134	46.0	COG2085@1|root,COG2085@2|Bacteria,3Y5CN@57723|Acidobacteria,2JNMR@204432|Acidobacteriia	204432|Acidobacteriia	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
CMS3_k127_7176552_1	765910.MARPU_00500	1.318e-167	541.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales	135613|Chromatiales	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_7176552_7	266835.14028163	1.881e-08	57.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,2UF5Q@28211|Alphaproteobacteria,43M26@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0337 (CsbD) family	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
CMS3_k127_7176552_6	1173024.KI912151_gene2421	5.629e-12	73.0	COG1544@1|root,COG1544@2|Bacteria,1GR8R@1117|Cyanobacteria	1117|Cyanobacteria	J	PFAM Sigma 54 modulation protein S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S30AE
CMS3_k127_7176552_3	903818.KI912268_gene651	3.296e-42	165.0	COG2197@1|root,COG2197@2|Bacteria,3Y669@57723|Acidobacteria	57723|Acidobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_7176552_5	472759.Nhal_1380	1.257e-21	101.0	COG0071@1|root,COG0071@2|Bacteria,1NPJI@1224|Proteobacteria,1SRY5@1236|Gammaproteobacteria,1X21C@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS3_k127_7176552_2	323261.Noc_1387	1.81e-69	248.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1S0BH@1236|Gammaproteobacteria,1X076@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
CMS3_k127_7177980_0	1121468.AUBR01000001_gene508	3.311e-75	266.0	COG0836@1|root,COG0836@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia,42FA6@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Nucleotidyl transferase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
CMS3_k127_7177980_1	237368.SCABRO_00201	0.000274	53.0	COG3164@1|root,COG3164@2|Bacteria	2|Bacteria	D	Protein of unknown function	MA20_30770	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	AsmA_1,AsmA_2,DUF3971
CMS3_k127_7179599_0	1274.HX89_10965	1.586e-11	74.0	COG1595@1|root,COG1595@2|Bacteria,2GM8T@201174|Actinobacteria,1ZWSX@145357|Dermacoccaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigD	GO:0000988,GO:0000990,GO:0002791,GO:0003674,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032879,GO:0032880,GO:0043254,GO:0044087,GO:0044419,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051223,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070201,GO:0080090,GO:0090087,GO:0140110,GO:1903506,GO:1903530,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_7180825_0	497964.CfE428DRAFT_4943	1.968e-255	835.0	COG0577@1|root,COG0577@2|Bacteria,46U6N@74201|Verrucomicrobia	74201|Verrucomicrobia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
CMS3_k127_7180825_1	497964.CfE428DRAFT_4944	1.034e-65	231.0	COG1136@1|root,COG1136@2|Bacteria,46V6W@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS3_k127_7180825_2	497964.CfE428DRAFT_4946	8.047e-43	164.0	2EK8J@1|root,33DYX@2|Bacteria,46VTQ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7196677_3	1235793.C809_01992	7.315e-22	99.0	COG1215@1|root,COG1215@2|Bacteria,1VEZB@1239|Firmicutes,24QW1@186801|Clostridia	186801|Clostridia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_7196677_1	391625.PPSIR1_13023	8.314e-78	271.0	COG0697@1|root,COG0697@2|Bacteria,1MXX1@1224|Proteobacteria,42UPB@68525|delta/epsilon subdivisions,2WS1K@28221|Deltaproteobacteria,2YVR9@29|Myxococcales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_7196677_0	679197.HMPREF9336_01692	1.402e-168	552.0	2DUQG@1|root,33RR5@2|Bacteria	2|Bacteria	S	HCO3- transporter family	-	-	-	-	-	-	-	-	-	-	-	-	HCO3_cotransp
CMS3_k127_7196677_2	1158345.JNLL01000001_gene228	1.189e-26	117.0	COG1472@1|root,COG1472@2|Bacteria,2G52S@200783|Aquificae	200783|Aquificae	G	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
CMS3_k127_7211430_1	626369.HMPREF0446_01597	2.524e-16	87.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,4HHD7@91061|Bacilli,27F7H@186828|Carnobacteriaceae	91061|Bacilli	O	Glycoprotease family	yeaZ	GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CMS3_k127_7211430_0	1123070.KB899261_gene2131	3.674e-102	347.0	COG1109@1|root,COG1109@2|Bacteria,46SJ2@74201|Verrucomicrobia,2ITTH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS3_k127_7212795_2	1144275.COCOR_02106	0.000361	53.0	COG0793@1|root,COG4932@1|root,COG0793@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	espK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K13735,ko:K18491,ko:K20276	ko02024,ko04550,ko05100,map02024,map04550,map05100	-	-	-	ko00000,ko00001,ko03000	-	-	-	CarboxypepD_reg,PDZ_2
CMS3_k127_7212795_1	1232453.BAIF02000089_gene2927	0.0001042	53.0	COG1361@1|root,COG3391@1|root,COG1361@2|Bacteria,COG3391@2|Bacteria,1UQ5B@1239|Firmicutes,24AUI@186801|Clostridia,26AGX@186813|unclassified Clostridiales	186801|Clostridia	M	SdrD B-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF3794,SdrD_B
CMS3_k127_7212795_0	314278.NB231_10158	7.286e-102	347.0	COG3637@1|root,COG3637@2|Bacteria,1R64D@1224|Proteobacteria,1S325@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
CMS3_k127_7227417_0	1210884.HG799471_gene14563	6.365e-70	266.0	COG0515@1|root,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_7227417_2	1452718.JBOY01000190_gene845	2.191e-07	61.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_7227417_1	448385.sce2398	1.443e-42	176.0	COG5164@1|root,COG5164@2|Bacteria,1N2FU@1224|Proteobacteria,42WNM@68525|delta/epsilon subdivisions,2WRNC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Collagen triple helix repeat (20 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen
CMS3_k127_7240551_0	1303518.CCALI_02907	1.446e-86	301.0	COG5267@1|root,COG5267@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
CMS3_k127_7240551_1	1121887.AUDK01000005_gene3159	2.342e-31	132.0	COG4102@1|root,COG4102@2|Bacteria,4NFFC@976|Bacteroidetes,1I0C6@117743|Flavobacteriia,2NSY9@237|Flavobacterium	976|Bacteroidetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_7244954_1	1379698.RBG1_1C00001G0516	1.498e-134	437.0	COG0473@1|root,COG0473@2|Bacteria,2NP1R@2323|unclassified Bacteria	2|Bacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CMS3_k127_7244954_0	1192034.CAP_4888	4.124e-313	970.0	COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2YX5D@29|Myxococcales	28221|Deltaproteobacteria	E	Aconitase C-terminal domain	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
CMS3_k127_7245697_1	1123242.JH636435_gene2087	1.438e-22	111.0	COG0515@1|root,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_7245697_0	867845.KI911784_gene2277	6.828e-65	239.0	COG0457@1|root,COG1404@1|root,COG3055@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,COG3055@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
CMS3_k127_7245697_3	864069.MicloDRAFT_00004930	1.866e-09	63.0	2CDYP@1|root,347WP@2|Bacteria,1P0GH@1224|Proteobacteria	1224|Proteobacteria	S	Family of unknown function (DUF5372)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5372
CMS3_k127_7245697_2	1446473.JHWH01000018_gene3750	5.687e-10	70.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2TVFI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA invertase Pin	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
CMS3_k127_7245697_4	216591.BCAM0443	0.0004487	49.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2VHHB@28216|Betaproteobacteria,1JZXJ@119060|Burkholderiaceae	28216|Betaproteobacteria	K	response regulator	irlR	-	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_7250816_2	1121861.KB899919_gene2679	3.607e-08	66.0	COG0421@1|root,COG0421@2|Bacteria,1QVKE@1224|Proteobacteria,2U21Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
CMS3_k127_7250816_1	497964.CfE428DRAFT_4578	2.137e-23	105.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN3	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
CMS3_k127_7250816_0	530564.Psta_1035	1.954e-131	443.0	COG1055@1|root,COG1055@2|Bacteria,2IY4X@203682|Planctomycetes	203682|Planctomycetes	P	COG1055 Na H antiporter NhaD and related arsenite	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS_2
CMS3_k127_7251059_0	1242864.D187_003866	1.702e-08	67.0	COG4932@1|root,COG4932@2|Bacteria,1Q2N2@1224|Proteobacteria,4388V@68525|delta/epsilon subdivisions,2X3IH@28221|Deltaproteobacteria,2YW8A@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,PDZ_2
CMS3_k127_7252298_2	589865.DaAHT2_1497	1.028e-08	64.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2MKZ2@213118|Desulfobacterales	28221|Deltaproteobacteria	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_7252298_1	1123508.JH636449_gene7349	1.129e-62	247.0	COG0515@1|root,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_7252922_3	237368.SCABRO_00336	0.0001622	51.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
CMS3_k127_7252922_0	290397.Adeh_1049	1.374e-59	225.0	COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
CMS3_k127_7252922_1	555779.Dthio_PD0835	1.759e-20	101.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,42N1F@68525|delta/epsilon subdivisions,2WK2V@28221|Deltaproteobacteria,2M8SJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM Phosphomethylpyrimidine kinase type-1	thiD	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00941,ko:K14153,ko:K21219	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2909	Phos_pyr_kin,TMP-TENI,ThiP_synth
CMS3_k127_7252922_2	195103.CPF_0267	4.27e-14	74.0	COG1134@1|root,COG1134@2|Bacteria,1TQKK@1239|Firmicutes,24A5V@186801|Clostridia,36DY5@31979|Clostridiaceae	186801|Clostridia	GM	ABC-type polysaccharide polyol phosphate transport system, ATPase component	tagH	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
CMS3_k127_7255466_1	284031.JNXD01000015_gene4457	0.0002358	54.0	COG1413@1|root,COG1413@2|Bacteria,2GKP6@201174|Actinobacteria	201174|Actinobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
CMS3_k127_7255466_0	1157708.KB907451_gene4762	6.926e-12	68.0	COG2867@1|root,COG2867@2|Bacteria,1N9F0@1224|Proteobacteria,2VWY4@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
CMS3_k127_7255503_0	880526.KE386488_gene1576	1.21e-91	337.0	COG0823@1|root,COG0823@2|Bacteria,4NIGD@976|Bacteroidetes,2G2P7@200643|Bacteroidia	976|Bacteroidetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7255503_2	1169161.KB897726_gene1399	1.022e-19	106.0	COG3537@1|root,COG3537@2|Bacteria,2GKYM@201174|Actinobacteria	201174|Actinobacteria	G	Alpha-1,2-mannosidase	-	-	-	-	-	-	-	-	-	-	-	-	CBM-like,Glyco_hydro_92,NPCBM_assoc
CMS3_k127_7255503_1	1278073.MYSTI_05966	3.384e-45	179.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2X799@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
CMS3_k127_7258777_4	227086.JGI_V11_58423	3.818e-23	99.0	COG0537@1|root,KOG3275@2759|Eukaryota	2759|Eukaryota	FG	nucleoside phosphate binding	HINT2	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0006629,GO:0008150,GO:0008152,GO:0009056,GO:0009892,GO:0010605,GO:0016042,GO:0019222,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0031974,GO:0031981,GO:0032268,GO:0032269,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070013,GO:0071704,GO:0080090,GO:1901575,GO:1901983,GO:1901984,GO:2000756,GO:2000757	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	iRC1080.CRv4_Au5_s6_g12858_t1	HIT
CMS3_k127_7258777_5	1168289.AJKI01000002_gene2514	1.309e-10	65.0	COG1141@1|root,COG1141@2|Bacteria,4P7D9@976|Bacteroidetes,2FZ83@200643|Bacteroidia	976|Bacteroidetes	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13
CMS3_k127_7258777_0	1192034.CAP_0044	4.391e-107	356.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,43AB6@68525|delta/epsilon subdivisions,2X259@28221|Deltaproteobacteria,2YZEP@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_7258777_1	743525.TSC_c19730	2.415e-90	322.0	COG0604@1|root,COG0604@2|Bacteria,1WI1Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	COG0604 NADPH quinone reductase and related Zn-dependent	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_7258777_2	518766.Rmar_1550	1.072e-80	276.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	paaA	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS3_k127_7258777_3	751944.HALDL1_07785	2.43e-43	173.0	COG1250@1|root,arCOG00250@2157|Archaea,2XT9S@28890|Euryarchaeota,23TDY@183963|Halobacteria	183963|Halobacteria	I	3-hydroxyacyl-CoA dehydrogenase	hbd3	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
CMS3_k127_7265308_1	1330700.JQNC01000003_gene704	1.784e-62	223.0	COG1960@1|root,COG1960@2|Bacteria,1WICI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_7265308_4	1071085.KK033114_gene1066	4.359e-35	141.0	COG3358@1|root,arCOG04570@2157|Archaea,2XWQ3@28890|Euryarchaeota,23V6T@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
CMS3_k127_7265308_3	269799.Gmet_1348	5.278e-42	166.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,42W4B@68525|delta/epsilon subdivisions,2WP0P@28221|Deltaproteobacteria,43UMI@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS3_k127_7265308_2	204669.Acid345_1339	5.946e-50	189.0	COG2912@1|root,COG2912@2|Bacteria,3Y53Z@57723|Acidobacteria,2JMYF@204432|Acidobacteriia	204432|Acidobacteriia	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
CMS3_k127_7265308_0	986075.CathTA2_1937	9.262e-166	532.0	COG0624@1|root,COG0624@2|Bacteria,1TP2D@1239|Firmicutes,4HB9G@91061|Bacilli	91061|Bacilli	E	COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases	dapE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_7265308_5	634177.GLX_08970	7.308e-06	50.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_7273165_0	398767.Glov_2292	8.706e-137	462.0	COG3303@1|root,COG3303@2|Bacteria,1R8WP@1224|Proteobacteria,42VEM@68525|delta/epsilon subdivisions,2WRGV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7277442_1	234267.Acid_2800	1.579e-104	348.0	COG0010@1|root,COG0010@2|Bacteria,3Y46E@57723|Acidobacteria	57723|Acidobacteria	E	Arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
CMS3_k127_7277442_3	671143.DAMO_2067	3.793e-50	190.0	COG1912@1|root,COG1912@2|Bacteria,2NPI0@2323|unclassified Bacteria	2|Bacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
CMS3_k127_7277442_0	479434.Sthe_1355	2.439e-126	420.0	COG1109@1|root,COG1109@2|Bacteria,2G5YP@200795|Chloroflexi,27XV0@189775|Thermomicrobia	189775|Thermomicrobia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS3_k127_7277442_2	1125863.JAFN01000001_gene1993	2.308e-56	205.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,42MZS@68525|delta/epsilon subdivisions,2WIQP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	aromatic amino acid beta-eliminating lyase threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
CMS3_k127_7281837_1	1041930.Mtc_0048	6.242e-28	121.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,2N9CA@224756|Methanomicrobia	224756|Methanomicrobia	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
CMS3_k127_7281837_0	243231.GSU3260	6.925e-86	296.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2WJQV@28221|Deltaproteobacteria,43S19@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_7281837_2	861299.J421_1466	0.0009364	50.0	2A0X4@1|root,30P27@2|Bacteria,1ZUWS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_72870_0	247490.KSU1_C0075	1.708e-76	290.0	COG1196@1|root,COG1196@2|Bacteria,2IY32@203682|Planctomycetes	203682|Planctomycetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
CMS3_k127_72870_1	237368.SCABRO_03334	3.798e-52	194.0	COG1327@1|root,COG1327@2|Bacteria,2IZQ3@203682|Planctomycetes	203682|Planctomycetes	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
CMS3_k127_7290641_1	1167006.UWK_01998	2.594e-41	171.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,42QJ7@68525|delta/epsilon subdivisions,2WPQE@28221|Deltaproteobacteria,2MKG7@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_7290641_0	383372.Rcas_0459	5.435e-53	199.0	COG1216@1|root,COG1216@2|Bacteria,2G6TR@200795|Chloroflexi,3769F@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
CMS3_k127_7290641_2	1121413.JMKT01000009_gene2070	1.469e-18	90.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,42NPA@68525|delta/epsilon subdivisions,2WT46@28221|Deltaproteobacteria,2MGS7@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
CMS3_k127_7292493_0	1403819.BATR01000092_gene2658	1.371e-178	571.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_7292493_1	765420.OSCT_0910	9.993e-46	188.0	COG0457@1|root,COG1716@1|root,COG4447@1|root,COG0457@2|Bacteria,COG1716@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CarboxypepD_reg,FHA,Kelch_4,NHL,PA14,Peptidase_C11
CMS3_k127_7292493_2	1122604.JONR01000002_gene1618	1.12e-36	157.0	COG3917@1|root,COG3917@2|Bacteria,1RJFB@1224|Proteobacteria,1S772@1236|Gammaproteobacteria,1X6G4@135614|Xanthomonadales	135614|Xanthomonadales	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
CMS3_k127_7292493_3	521674.Plim_0454	2.199e-19	95.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	1.3.7.14,1.3.7.15	ko:K03088,ko:K11333	ko00860,ko01110,map00860,map01110	-	R09053,R09060	RC01008	ko00000,ko00001,ko01000,ko03021	-	-	-	Fer4_NifH,Glyco_hydro_cc,Laminin_G_3,Sigma70_r2,Sigma70_r4_2
CMS3_k127_7293762_1	234267.Acid_2720	5.442e-141	461.0	COG0624@1|root,COG0624@2|Bacteria,3Y2UM@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_7293762_0	661478.OP10G_0856	2.818e-194	626.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	yuxL	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
CMS3_k127_7293762_2	448385.sce2686	4.442e-19	102.0	COG2319@1|root,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,42P8D@68525|delta/epsilon subdivisions,2WMH1@28221|Deltaproteobacteria,2YU5N@29|Myxococcales	28221|Deltaproteobacteria	T	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,WD40
CMS3_k127_730851_1	330214.NIDE4149	0.0007594	51.0	COG1413@1|root,COG1413@2|Bacteria,3J1E2@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS3_k127_730851_0	1123242.JH636435_gene2890	1.558e-15	90.0	COG2304@1|root,COG2304@2|Bacteria,2J43F@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_3
CMS3_k127_7313295_5	861299.J421_1879	1.707e-82	287.0	COG1252@1|root,COG1252@2|Bacteria,1ZT8C@142182|Gemmatimonadetes	2|Bacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
CMS3_k127_7313295_0	861299.J421_3883	2.427e-251	783.0	COG1429@1|root,COG1429@2|Bacteria	2|Bacteria	H	ligase activity, forming nitrogen-metal bonds	cobN	-	6.6.1.2	ko:K02230	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobN-Mg_chel,Glyco_hydro_63
CMS3_k127_7313295_2	215803.DB30_4886	7.339e-157	504.0	COG1429@1|root,COG1429@2|Bacteria,1QX7D@1224|Proteobacteria,43C0E@68525|delta/epsilon subdivisions,2X7B3@28221|Deltaproteobacteria,2Z3EW@29|Myxococcales	28221|Deltaproteobacteria	H	Glycosyl hydrolase family 63 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
CMS3_k127_7313295_3	251221.35211725	2.809e-108	375.0	COG0346@1|root,COG0346@2|Bacteria,1G29P@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_7313295_1	56107.Cylst_1188	2.626e-215	683.0	COG2303@1|root,COG2303@2|Bacteria,1G2DQ@1117|Cyanobacteria,1HQ1V@1161|Nostocales	1117|Cyanobacteria	E	PFAM GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
CMS3_k127_7313295_7	861299.J421_1880	1.249e-40	169.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DM13
CMS3_k127_7313295_6	211165.AJLN01000133_gene5922	1.96e-76	276.0	COG0580@1|root,COG0580@2|Bacteria,1G3MJ@1117|Cyanobacteria	1117|Cyanobacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
CMS3_k127_7313295_4	861299.J421_1875	5.782e-83	284.0	COG0662@1|root,COG3193@1|root,COG0662@2|Bacteria,COG3193@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	ko:K11477	-	-	-	-	ko00000	-	-	-	Cupin_2,Haem_degrading
CMS3_k127_7313295_9	1242864.D187_001368	8.941e-26	120.0	COG0836@1|root,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,42MDP@68525|delta/epsilon subdivisions,2WJEN@28221|Deltaproteobacteria,2YUTZ@29|Myxococcales	28221|Deltaproteobacteria	M	Mannose-6-phosphate isomerase	manAC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
CMS3_k127_7313295_8	1379270.AUXF01000007_gene997	6.016e-27	118.0	COG2819@1|root,COG2819@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS3_k127_7323576_6	1297742.A176_05903	6.195e-10	72.0	COG4932@1|root,COG5184@1|root,COG4932@2|Bacteria,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	-	ko:K14475,ko:K20276	ko02024,ko05143,map02024,map05143	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,RCC1_2
CMS3_k127_7323576_1	880073.Calab_2988	1.348e-95	320.0	COG2013@1|root,COG2013@2|Bacteria,2NQA0@2323|unclassified Bacteria	2|Bacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
CMS3_k127_7323576_4	319225.Plut_0743	2.058e-39	156.0	COG0838@1|root,COG0838@2|Bacteria,1FDY8@1090|Chlorobi	1090|Chlorobi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
CMS3_k127_7323576_3	1123242.JH636436_gene424	2.783e-80	270.0	COG0377@1|root,COG0377@2|Bacteria,2IY3F@203682|Planctomycetes	203682|Planctomycetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
CMS3_k127_7323576_5	1123508.JH636445_gene6542	1.498e-34	146.0	COG0852@1|root,COG0852@2|Bacteria,2IZCK@203682|Planctomycetes	203682|Planctomycetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
CMS3_k127_7323576_0	880073.Calab_2690	1.732e-134	439.0	COG0649@1|root,COG0649@2|Bacteria,2NNXB@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
CMS3_k127_7323576_2	1210884.HG799468_gene13764	2.256e-92	317.0	COG1005@1|root,COG1005@2|Bacteria,2IXUX@203682|Planctomycetes	203682|Planctomycetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
CMS3_k127_7336971_3	555779.Dthio_PD2817	0.0001483	48.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2M7VS@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,PAS_9,Sigma54_activat
CMS3_k127_7336971_2	1123274.KB899460_gene3987	6.038e-91	309.0	COG0652@1|root,COG0652@2|Bacteria,2J58N@203691|Spirochaetes	203691|Spirochaetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	FKBP_C,Pro_isomerase
CMS3_k127_7336971_1	1121904.ARBP01000001_gene5603	5.717e-160	513.0	COG0673@1|root,COG0673@2|Bacteria,4NEC6@976|Bacteroidetes,47KZS@768503|Cytophagia	976|Bacteroidetes	S	PFAM Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_7336971_0	335543.Sfum_3546	5.062e-208	670.0	COG1216@1|root,COG3250@1|root,COG1216@2|Bacteria,COG3250@2|Bacteria,1R42U@1224|Proteobacteria,42UMM@68525|delta/epsilon subdivisions,2WQVW@28221|Deltaproteobacteria,2MS0N@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
CMS3_k127_7340840_0	595460.RRSWK_03194	6.222e-133	440.0	COG2239@1|root,COG2239@2|Bacteria,2IYCZ@203682|Planctomycetes	203682|Planctomycetes	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
CMS3_k127_7340840_1	595460.RRSWK_03471	8.332e-07	60.0	COG1657@1|root,COG1657@2|Bacteria,2J1Q5@203682|Planctomycetes	203682|Planctomycetes	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7342999_0	331869.BAL199_28445	8.953e-157	500.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria,4BPGN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	HflC and HflK could regulate a protease	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS3_k127_7342999_1	247633.GP2143_04103	1.325e-152	490.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RPUE@1236|Gammaproteobacteria,1J825@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	HflC and HflK could encode or regulate a protease	-	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
CMS3_k127_7342999_2	1267533.KB906738_gene2028	9.748e-149	480.0	COG2152@1|root,COG2152@2|Bacteria	2|Bacteria	G	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
CMS3_k127_7342999_3	518766.Rmar_1363	1.127e-143	469.0	COG0438@1|root,COG0438@2|Bacteria,4NEW7@976|Bacteroidetes	976|Bacteroidetes	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_7342999_4	1121396.KB893077_gene738	7e-12	65.0	COG0438@1|root,COG0438@2|Bacteria,1R3Q9@1224|Proteobacteria,42MQ2@68525|delta/epsilon subdivisions,2WM1F@28221|Deltaproteobacteria,2MQ1W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_7343300_3	521674.Plim_3943	6.146e-07	59.0	COG0526@1|root,COG0526@2|Bacteria,2IZKM@203682|Planctomycetes	203682|Planctomycetes	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin,Thioredoxin_8
CMS3_k127_7343300_4	483219.LILAB_18210	4.519e-05	48.0	COG0526@1|root,COG0526@2|Bacteria,1RHR7@1224|Proteobacteria,42WV1@68525|delta/epsilon subdivisions,2WSIX@28221|Deltaproteobacteria,2YVQA@29|Myxococcales	28221|Deltaproteobacteria	CO	Thioredoxin-like	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_7343300_0	1123242.JH636438_gene5738	1.86e-144	473.0	COG2204@1|root,COG2204@2|Bacteria,2IXIQ@203682|Planctomycetes	203682|Planctomycetes	T	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_7343300_2	309807.SRU_1229	1.371e-15	85.0	COG1012@1|root,COG1012@2|Bacteria,4NZV1@976|Bacteroidetes	976|Bacteroidetes	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
CMS3_k127_7343300_1	1382306.JNIM01000001_gene1511	1.036e-69	245.0	COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12,TPR_8
CMS3_k127_7344682_1	1122135.KB893166_gene3101	2.991e-26	128.0	COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	response regulator containing a CheY-like receiver domain and a GGDEF domain	pleD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
CMS3_k127_7344682_0	313628.LNTAR_07229	1.514e-106	352.0	COG3119@1|root,COG3119@2|Bacteria	313628.LNTAR_07229|-	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7360598_0	1267535.KB906767_gene3320	1.491e-66	235.0	COG4993@1|root,COG4993@2|Bacteria,3Y639@57723|Acidobacteria	57723|Acidobacteria	G	PQQ enzyme repeat	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ
CMS3_k127_7360598_1	157072.XP_008861889.1	1.028e-27	130.0	COG0457@1|root,KOG1124@2759|Eukaryota	2759|Eukaryota	O	cellular component assembly	-	-	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_16,TPR_8
CMS3_k127_7373241_1	1403819.BATR01000088_gene2611	2.824e-22	111.0	2BMSD@1|root,32GBT@2|Bacteria,46VIR@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7373241_0	247634.GPB2148_859	1.818e-181	580.0	COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,1RNCS@1236|Gammaproteobacteria,1J4KH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the UPF0061 (SELO) family	ydiU	-	-	ko:K08997	-	-	-	-	ko00000	-	-	-	UPF0061
CMS3_k127_7378509_5	373903.Hore_21410	0.0006531	51.0	COG1388@1|root,COG1388@2|Bacteria,1TSVC@1239|Firmicutes,248VQ@186801|Clostridia,3WBGV@53433|Halanaerobiales	186801|Clostridia	M	Domain of unknown function (DUF3794)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3794,LysM
CMS3_k127_7378509_4	742821.HMPREF9464_00460	5.929e-15	87.0	COG0515@1|root,COG0515@2|Bacteria,1N75K@1224|Proteobacteria,2W05P@28216|Betaproteobacteria,4PQYC@995019|Sutterellaceae	28216|Betaproteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7378509_2	314345.SPV1_01092	1.56e-16	88.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CMS3_k127_7378509_1	575540.Isop_0530	7.264e-42	170.0	COG1212@1|root,COG1212@2|Bacteria,2IYWF@203682|Planctomycetes	203682|Planctomycetes	H	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
CMS3_k127_7378509_0	575540.Isop_1555	1.407e-218	696.0	COG0504@1|root,COG0504@2|Bacteria,2IXNE@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
CMS3_k127_7378509_3	314230.DSM3645_07246	8.292e-16	81.0	2EAFJ@1|root,334IY@2|Bacteria,2J12W@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
CMS3_k127_7380333_4	357808.RoseRS_2451	0.0008911	51.0	COG4870@1|root,COG4932@1|root,COG5513@1|root,COG4870@2|Bacteria,COG4932@2|Bacteria,COG5513@2|Bacteria,2GA24@200795|Chloroflexi,377PH@32061|Chloroflexia	2|Bacteria	MO	Carboxypeptidase regulatory-like domain	-	-	3.4.22.15	ko:K01365,ko:K02030,ko:K14475	ko04140,ko04142,ko04145,ko04210,ko04612,ko05143,ko05205,ko05323,ko05418,map04140,map04142,map04145,map04210,map04612,map05143,map05205,map05323,map05418	M00236	-	-	ko00000,ko00001,ko00002,ko00537,ko01000,ko01002,ko02000,ko03110	3.A.1.3	-	-	CarboxypepD_reg,Inhibitor_I42,Peptidase_C1
CMS3_k127_7380333_0	28444.JODQ01000006_gene629	1.271e-33	137.0	COG3963@1|root,COG3963@2|Bacteria,2I93P@201174|Actinobacteria,4EJ7V@85012|Streptosporangiales	201174|Actinobacteria	I	Phospholipid N-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,RrnaAD
CMS3_k127_7380333_1	509635.N824_18050	1.07e-19	95.0	COG1541@1|root,COG1541@2|Bacteria,4PKJA@976|Bacteroidetes,1IP9C@117747|Sphingobacteriia	976|Bacteroidetes	H	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
CMS3_k127_7385794_0	502025.Hoch_3204	0.0	1217.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,42MYQ@68525|delta/epsilon subdivisions,2WJM2@28221|Deltaproteobacteria,2YTST@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
CMS3_k127_7385794_3	35754.JNYJ01000061_gene2416	3.785e-40	168.0	COG0840@1|root,COG0840@2|Bacteria,2GJV0@201174|Actinobacteria,4DI6G@85008|Micromonosporales	201174|Actinobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,MCPsignal
CMS3_k127_7385794_4	118168.MC7420_4893	4.646e-39	151.0	COG0835@1|root,COG0835@2|Bacteria,1G8DQ@1117|Cyanobacteria,1HCC0@1150|Oscillatoriales	1117|Cyanobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
CMS3_k127_7385794_1	935866.JAER01000040_gene522	5.421e-192	622.0	COG0643@1|root,COG0643@2|Bacteria,2IBKY@201174|Actinobacteria,4DT86@85009|Propionibacteriales	201174|Actinobacteria	NT	Signal transducing histidine kinase, homodimeric domain	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
CMS3_k127_7385794_2	530564.Psta_3072	1.291e-80	282.0	COG0840@1|root,COG0840@2|Bacteria,2IXQA@203682|Planctomycetes	203682|Planctomycetes	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K02660,ko:K03406	ko02020,ko02025,ko02030,map02020,map02025,map02030	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Globin,HAMP,MCPsignal,PAS_3,PAS_4,PAS_9
CMS3_k127_7385794_5	765420.OSCT_0910	4.825e-28	130.0	COG0457@1|root,COG1716@1|root,COG4447@1|root,COG0457@2|Bacteria,COG1716@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CarboxypepD_reg,FHA,Kelch_4,NHL,PA14,Peptidase_C11
CMS3_k127_7387185_5	1254432.SCE1572_52290	6.891e-06	59.0	COG4932@1|root,COG4932@2|Bacteria,1PYE0@1224|Proteobacteria,43E3U@68525|delta/epsilon subdivisions,2X97I@28221|Deltaproteobacteria,2Z2E0@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_7387185_2	649638.Trad_2464	3.321e-99	344.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	ANKH,MatE
CMS3_k127_7387185_1	522306.CAP2UW1_1635	8.109e-146	468.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2VM08@28216|Betaproteobacteria,1KQ46@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	adh	-	1.1.1.1,1.1.1.258	ko:K12957,ko:K13953,ko:K19961	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00930,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00930,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R05283,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_7387185_4	1117319.PSPO_19801	3.019e-25	124.0	COG2335@1|root,COG4315@1|root,COG2335@2|Bacteria,COG4315@2|Bacteria,1RD06@1224|Proteobacteria,1RSMY@1236|Gammaproteobacteria,2Q18Y@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	COG2335 Secreted and surface protein containing fasciclin-like repeats	-	-	-	ko:K19519	-	-	-	-	ko00000,ko04516	-	-	-	Fasciclin,Lipoprotein_15
CMS3_k127_7387185_0	1123070.KB899255_gene1400	0.0	1052.0	COG1404@1|root,COG1858@1|root,COG4257@1|root,COG1404@2|Bacteria,COG1858@2|Bacteria,COG4257@2|Bacteria,46U0N@74201|Verrucomicrobia,2IUGP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
CMS3_k127_7387185_3	756272.Plabr_2034	1.903e-59	214.0	COG0635@1|root,COG0635@2|Bacteria,2IY84@203682|Planctomycetes	203682|Planctomycetes	H	COG0635 Coproporphyrinogen III oxidase and related Fe-S	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS3_k127_738727_0	1123065.ATWL01000006_gene2307	1.408e-96	337.0	COG1082@1|root,COG1082@2|Bacteria,2I94Z@201174|Actinobacteria	201174|Actinobacteria	G	BNR repeat-containing family member	-	-	-	-	-	-	-	-	-	-	-	-	BNR_4
CMS3_k127_738727_1	1267534.KB906755_gene4272	1.384e-29	130.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	AAA_19,Ank,Ank_2,Ank_3,Ank_4,Ank_5,Sigma70_r2,Sigma70_r4,Viral_helicase1
CMS3_k127_7390950_0	227086.JGI_V11_58423	3.754e-48	175.0	COG0537@1|root,KOG3275@2759|Eukaryota	2759|Eukaryota	FG	nucleoside phosphate binding	HINT2	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0006629,GO:0008150,GO:0008152,GO:0009056,GO:0009892,GO:0010605,GO:0016042,GO:0019222,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0031974,GO:0031981,GO:0032268,GO:0032269,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070013,GO:0071704,GO:0080090,GO:1901575,GO:1901983,GO:1901984,GO:2000756,GO:2000757	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	iRC1080.CRv4_Au5_s6_g12858_t1	HIT
CMS3_k127_7390950_1	1122194.AUHU01000003_gene2153	8.423e-42	156.0	COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1S62I@1236|Gammaproteobacteria,467E8@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
CMS3_k127_7390950_2	1121948.AUAC01000006_gene601	1.418e-26	119.0	COG0393@1|root,COG0393@2|Bacteria,1QDHW@1224|Proteobacteria,2V9F5@28211|Alphaproteobacteria,440AP@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
CMS3_k127_7390950_3	511680.BUTYVIB_00943	0.0005072	51.0	COG2339@1|root,COG2339@2|Bacteria,1V3JI@1239|Firmicutes,24AZQ@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
CMS3_k127_7402968_0	1499686.BN1079_01943	7.773e-74	270.0	COG0438@1|root,COG2148@1|root,COG0438@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1RMMN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG2148 Sugar transferases involved in lipopolysaccharide synthesis	epsL	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
CMS3_k127_7402968_1	471223.GWCH70_3255	8.982e-73	256.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	ATP-grasp_3,Dala_Dala_lig_C,Dala_Dala_lig_N
CMS3_k127_7402968_2	446466.Cfla_0765	3.32e-20	103.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CMS3_k127_7404956_0	886293.Sinac_0956	4.487e-160	535.0	COG2010@1|root,COG2010@2|Bacteria,2IWY5@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PA14,PSCyt1,PSCyt2,PSD1
CMS3_k127_7404956_1	314230.DSM3645_06324	3.706e-111	391.0	COG1520@1|root,COG1520@2|Bacteria,2IWVC@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_7407715_0	497964.CfE428DRAFT_5027	2.715e-136	446.0	COG1520@1|root,COG1520@2|Bacteria,46U9S@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_7407715_2	338963.Pcar_1480	3.566e-28	119.0	COG0023@1|root,COG0023@2|Bacteria,1MZ8T@1224|Proteobacteria,42TW6@68525|delta/epsilon subdivisions,2WQNT@28221|Deltaproteobacteria,43SNP@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Translation initiation factor SUI1	yciH	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
CMS3_k127_7407715_1	661478.OP10G_4632	3.574e-45	176.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
CMS3_k127_7417405_0	861299.J421_4478	3.334e-163	530.0	COG1574@1|root,COG1574@2|Bacteria,1ZU9S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS3_k127_7417405_1	246197.MXAN_6725	7.675e-05	52.0	COG0793@1|root,COG4932@1|root,COG0793@2|Bacteria,COG4932@2|Bacteria,1Q2N3@1224|Proteobacteria,4388W@68525|delta/epsilon subdivisions,2XA2N@28221|Deltaproteobacteria,2YXAB@29|Myxococcales	28221|Deltaproteobacteria	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,PDZ_2
CMS3_k127_7425520_7	1185653.A1A1_06902	8.53e-08	64.0	COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,4H9N3@91061|Bacilli,26FEN@186818|Planococcaceae	91061|Bacilli	L	hydrolase (metallo-beta-lactamase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Lactamase_B,SLH
CMS3_k127_7425520_2	1232428.CAVO010000066_gene340	6.344e-40	155.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,4H4H3@909932|Negativicutes	909932|Negativicutes	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
CMS3_k127_7425520_3	338963.Pcar_2536	4.226e-28	118.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,42UZH@68525|delta/epsilon subdivisions,2WR2R@28221|Deltaproteobacteria,43VP8@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
CMS3_k127_7425520_5	211165.AJLN01000065_gene3652	1.791e-14	86.0	COG4767@1|root,COG4767@2|Bacteria,1G359@1117|Cyanobacteria,1JMWR@1189|Stigonemataceae	1117|Cyanobacteria	V	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,VanZ
CMS3_k127_7425520_6	96561.Dole_2966	8.738e-10	68.0	2C5AX@1|root,33J9J@2|Bacteria,1NNQH@1224|Proteobacteria,433PI@68525|delta/epsilon subdivisions,2WY12@28221|Deltaproteobacteria,2MP9G@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7425520_4	768671.ThimaDRAFT_1945	4.839e-15	84.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,1RQSM@1236|Gammaproteobacteria,1WYMP@135613|Chromatiales	135613|Chromatiales	M	polysaccharide export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
CMS3_k127_7425520_0	404589.Anae109_0662	1.546e-117	394.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,42PCD@68525|delta/epsilon subdivisions,2WKGQ@28221|Deltaproteobacteria,2YU9M@29|Myxococcales	28221|Deltaproteobacteria	F	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis	pdp	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
CMS3_k127_7425938_0	67593.Physo157244	3.994e-47	192.0	COG1250@1|root,KOG2304@2759|Eukaryota,3Q7F0@4776|Peronosporales	4776|Peronosporales	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.35	ko:K00022	ko00062,ko00071,ko00280,ko00281,ko00310,ko00380,ko00650,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00062,map00071,map00280,map00281,map00310,map00380,map00650,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00085,M00087	R01778,R01975,R04203,R04737,R04739,R04741,R04743,R04745,R04748,R05066,R06941,R08094	RC00029,RC00099,RC00103,RC00117,RC00241,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N
CMS3_k127_7428110_0	63737.Npun_F1222	5.573e-57	223.0	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1HINJ@1161|Nostocales	1117|Cyanobacteria	L	PFAM WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
CMS3_k127_7428110_4	1236514.BAKL01000014_gene1575	0.0006241	51.0	COG4232@1|root,COG4232@2|Bacteria,4NEW6@976|Bacteroidetes,2FNDE@200643|Bacteroidia,4ANMH@815|Bacteroidaceae	976|Bacteroidetes	CO	cytochrome c biogenesis protein transmembrane region	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
CMS3_k127_7428110_2	1121129.KB903372_gene300	4.835e-20	101.0	COG4232@1|root,COG4232@2|Bacteria,4NH5B@976|Bacteroidetes,2FWD6@200643|Bacteroidia,22ZJ9@171551|Porphyromonadaceae	976|Bacteroidetes	CO	Disulphide bond corrector protein DsbC	-	-	-	-	-	-	-	-	-	-	-	-	DsbC
CMS3_k127_7428110_3	62928.azo2959	2.041e-14	78.0	COG0599@1|root,COG0599@2|Bacteria,1P85X@1224|Proteobacteria,2W5YK@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
CMS3_k127_7428110_1	338969.Rfer_3144	2.895e-55	199.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_74325_0	1121930.AQXG01000004_gene2997	2.436e-95	327.0	COG0413@1|root,COG0413@2|Bacteria,4NDX4@976|Bacteroidetes,1IRN1@117747|Sphingobacteriia	976|Bacteroidetes	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
CMS3_k127_74325_1	290397.Adeh_0279	1.646e-89	317.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,42QKZ@68525|delta/epsilon subdivisions,2WJ74@28221|Deltaproteobacteria,2YU8X@29|Myxococcales	28221|Deltaproteobacteria	H	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
CMS3_k127_7442710_0	526227.Mesil_1866	6.351e-57	205.0	COG1611@1|root,COG1611@2|Bacteria	2|Bacteria	S	cytokinin biosynthetic process	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS3_k127_7442710_1	395961.Cyan7425_0411	1.83e-37	146.0	COG1611@1|root,COG1611@2|Bacteria,1G5P3@1117|Cyanobacteria,3KI0E@43988|Cyanothece	1117|Cyanobacteria	S	TIGRFAM TIGR00725 family protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS3_k127_7442710_4	62928.azo0278	3.048e-06	60.0	2EFNF@1|root,339EK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7442710_2	1210884.HG799462_gene7921	1.37e-31	127.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
CMS3_k127_7444693_2	652103.Rpdx1_4127	1.156e-130	436.0	COG1924@1|root,COG1924@2|Bacteria,1R411@1224|Proteobacteria,2U1DN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Benzoyl-CoA reductase subunit	-	-	1.3.7.8	ko:K04114	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	BcrAD_BadFG
CMS3_k127_7444693_0	652103.Rpdx1_4128	2.758e-195	621.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,2U31W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	benzoyl-CoA reductase	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
CMS3_k127_7444693_3	85643.Tmz1t_2951	5.259e-129	437.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,2VV78@28216|Betaproteobacteria,2KXPH@206389|Rhodocyclales	206389|Rhodocyclales	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
CMS3_k127_7444693_5	443144.GM21_2822	5.435e-76	263.0	COG1024@1|root,COG1024@2|Bacteria,1R7WW@1224|Proteobacteria,42NZQ@68525|delta/epsilon subdivisions,2WMCW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.100	ko:K07537	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05597	RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_7444693_1	1187851.A33M_3194	8.228e-150	481.0	COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,2U4PY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	3.7.1.21	ko:K07539	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05593,R05594,R10696	RC01430,RC01431,RC03237	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_7444693_4	85643.Tmz1t_2954	1.849e-125	411.0	COG1064@1|root,COG1064@2|Bacteria,1QVIH@1224|Proteobacteria,2VP5E@28216|Betaproteobacteria,2KVHQ@206389|Rhodocyclales	28216|Betaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.1.1.368	ko:K07538	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05581	RC00850	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_7444693_6	1192034.CAP_7356	1.247e-29	128.0	COG1397@1|root,COG1397@2|Bacteria	2|Bacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7446887_0	502025.Hoch_1870	1.043e-222	711.0	COG3303@1|root,COG3303@2|Bacteria,1QXPE@1224|Proteobacteria	1224|Proteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	cbcM	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
CMS3_k127_7446887_1	880073.Calab_3333	1.697e-31	131.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_744998_1	1120936.KB907214_gene4557	2.381e-126	429.0	COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria,4EH97@85012|Streptosporangiales	201174|Actinobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
CMS3_k127_744998_0	502025.Hoch_0072	8.953e-228	723.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,42MXV@68525|delta/epsilon subdivisions,2WIIT@28221|Deltaproteobacteria,2YY6V@29|Myxococcales	28221|Deltaproteobacteria	C	Pyruvate flavodoxin ferredoxin	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
CMS3_k127_7452406_2	886293.Sinac_7483	2.599e-37	151.0	COG0515@1|root,COG0515@2|Bacteria,2IYTQ@203682|Planctomycetes	203682|Planctomycetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16
CMS3_k127_7452406_1	1267535.KB906767_gene4499	5.834e-42	175.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria,2JJS7@204432|Acidobacteriia	204432|Acidobacteriia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS3_k127_7452406_3	330214.NIDE1725	4.884e-29	132.0	COG4447@1|root,COG4447@2|Bacteria,3J16A@40117|Nitrospirae	40117|Nitrospirae	S	Photosynthesis system II assembly factor YCF48	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
CMS3_k127_7452406_0	502025.Hoch_2256	4.375e-46	181.0	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,42T1K@68525|delta/epsilon subdivisions,2WP7Y@28221|Deltaproteobacteria,2YXPS@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F
CMS3_k127_7454956_0	1051632.TPY_0383	1.373e-33	143.0	COG2912@1|root,COG2912@2|Bacteria,1VXJ8@1239|Firmicutes,25294@186801|Clostridia	186801|Clostridia	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core2
CMS3_k127_74554_0	143224.JQMD01000002_gene2475	7.028e-175	559.0	COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes,1HX8I@117743|Flavobacteriia	976|Bacteroidetes	P	Arylsulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
CMS3_k127_74554_4	69279.BG36_18935	1.609e-13	82.0	2DPZ8@1|root,3341I@2|Bacteria,1N7WK@1224|Proteobacteria,2UHE6@28211|Alphaproteobacteria,43QSB@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_74554_3	760192.Halhy_1712	4.916e-17	93.0	2CIH2@1|root,2ZTG0@2|Bacteria,4NNM2@976|Bacteroidetes,1IZRE@117747|Sphingobacteriia	976|Bacteroidetes	S	Putative lumazine-binding	-	-	-	-	-	-	-	-	-	-	-	-	Lumazine_bd_2
CMS3_k127_74554_2	1237149.C900_00535	1.774e-25	119.0	2CIH2@1|root,2ZTG0@2|Bacteria,4NNM2@976|Bacteroidetes,47VGE@768503|Cytophagia	976|Bacteroidetes	S	Putative lumazine-binding	-	-	-	-	-	-	-	-	-	-	-	-	Lumazine_bd_2
CMS3_k127_74554_1	1336233.JAEH01000028_gene403	8.653e-67	246.0	COG3137@1|root,COG3137@2|Bacteria,1RCKQ@1224|Proteobacteria,1S0GK@1236|Gammaproteobacteria,2QA2B@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
CMS3_k127_7457862_0	309801.trd_0526	8.503e-109	364.0	COG0489@1|root,COG0489@2|Bacteria,2G60P@200795|Chloroflexi,27XJW@189775|Thermomicrobia	189775|Thermomicrobia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
CMS3_k127_7457862_1	1380394.JADL01000004_gene6046	1.302e-81	280.0	COG0384@1|root,COG0384@2|Bacteria,1R9X4@1224|Proteobacteria,2U4TZ@28211|Alphaproteobacteria,2JRES@204441|Rhodospirillales	204441|Rhodospirillales	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
CMS3_k127_7465872_1	144197.XP_008289499.1	2.43e-32	145.0	COG0457@1|root,KOG1124@2759|Eukaryota,38CY4@33154|Opisthokonta,3BAFG@33208|Metazoa,3CV6Z@33213|Bilateria,480W8@7711|Chordata,4967I@7742|Vertebrata,49V00@7898|Actinopterygii	33208|Metazoa	S	Transmembrane and tetratricopeptide repeat containing 3	TMTC3	GO:0001763,GO:0002009,GO:0003401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006950,GO:0007275,GO:0008150,GO:0009653,GO:0009791,GO:0009887,GO:0009888,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010468,GO:0010604,GO:0012505,GO:0019222,GO:0030154,GO:0030162,GO:0030323,GO:0030324,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0033554,GO:0034976,GO:0035239,GO:0035295,GO:0040007,GO:0042176,GO:0042692,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0045732,GO:0045862,GO:0048286,GO:0048468,GO:0048513,GO:0048518,GO:0048522,GO:0048589,GO:0048729,GO:0048731,GO:0048747,GO:0048754,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051146,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051716,GO:0055001,GO:0055002,GO:0060255,GO:0060425,GO:0060429,GO:0060441,GO:0060447,GO:0060541,GO:0060560,GO:0060562,GO:0060602,GO:0061061,GO:0061136,GO:0061138,GO:0065007,GO:0080090,GO:1901800,GO:1903050,GO:1903052,GO:1903362,GO:1903364	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
CMS3_k127_7465872_0	290397.Adeh_2510	3.397e-143	459.0	COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,42PEB@68525|delta/epsilon subdivisions,2WM0Y@28221|Deltaproteobacteria,2Z349@29|Myxococcales	28221|Deltaproteobacteria	G	DeoC/LacD family aldolase	fbaB	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
CMS3_k127_7465872_2	1210884.HG799465_gene11662	1.218e-10	66.0	COG0582@1|root,COG0582@2|Bacteria,2IYXX@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
CMS3_k127_7468251_5	324602.Caur_0649	1.779e-42	169.0	COG1404@1|root,COG4447@1|root,COG1404@2|Bacteria,COG4447@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
CMS3_k127_7468251_0	1173027.Mic7113_5860	1.682e-132	434.0	COG2230@1|root,COG2230@2|Bacteria,1G3TN@1117|Cyanobacteria,1H8KG@1150|Oscillatoriales	1117|Cyanobacteria	M	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
CMS3_k127_7468251_8	517418.Ctha_2258	9.464e-08	65.0	COG4288@1|root,COG4288@2|Bacteria,1FE3D@1090|Chlorobi	1090|Chlorobi	S	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FlgD_ig,LTD
CMS3_k127_7468251_3	483219.LILAB_01555	1.457e-45	179.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	estX	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
CMS3_k127_7468251_1	1121861.KB899920_gene2846	4.545e-91	313.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria,2JRNW@204441|Rhodospirillales	204441|Rhodospirillales	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7468251_7	1123073.KB899241_gene3373	2.748e-11	72.0	COG1595@1|root,COG1595@2|Bacteria,1QGJA@1224|Proteobacteria,1TDZF@1236|Gammaproteobacteria,1XB8H@135614|Xanthomonadales	135614|Xanthomonadales	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7468251_2	483219.LILAB_04420	1.623e-61	238.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,438D9@68525|delta/epsilon subdivisions,2X3NF@28221|Deltaproteobacteria,2YWN6@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_7468251_4	1281779.H009_06382	2e-44	182.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2TQUH@28211|Alphaproteobacteria,4BBYY@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	amine oxidase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase
CMS3_k127_7468251_9	1123242.JH636437_gene5945	0.0002922	49.0	COG1595@1|root,COG1595@2|Bacteria,2IZFC@203682|Planctomycetes	203682|Planctomycetes	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ECF,Sigma70_r2,Sigma70_r4_2
CMS3_k127_7469815_0	344747.PM8797T_15676	1.776e-302	962.0	COG0726@1|root,COG1413@1|root,COG2133@1|root,COG3474@1|root,COG0726@2|Bacteria,COG1413@2|Bacteria,COG2133@2|Bacteria,COG3474@2|Bacteria,2IXJQ@203682|Planctomycetes	203682|Planctomycetes	C	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,HEAT_2,VCBS
CMS3_k127_7469815_1	504472.Slin_0602	2.696e-12	80.0	COG3356@1|root,COG3356@2|Bacteria,4NJPV@976|Bacteroidetes,47JM2@768503|Cytophagia	976|Bacteroidetes	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
CMS3_k127_7476362_1	869213.JCM21142_42013	1.373e-07	60.0	28N6X@1|root,2ZBBQ@2|Bacteria	2|Bacteria	S	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_7476362_0	143224.JQMD01000002_gene2462	1.16e-17	84.0	COG2133@1|root,COG2133@2|Bacteria,4NF61@976|Bacteroidetes,1I8IY@117743|Flavobacteriia	976|Bacteroidetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS3_k127_7486934_1	388413.ALPR1_21202	2.148e-37	154.0	COG2234@1|root,COG2234@2|Bacteria,4NMH1@976|Bacteroidetes	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS3_k127_7486934_2	1254432.SCE1572_39595	6.534e-17	92.0	2AGUQ@1|root,31732@2|Bacteria,1PYBC@1224|Proteobacteria,43E2X@68525|delta/epsilon subdivisions,2WZJA@28221|Deltaproteobacteria,2Z299@29|Myxococcales	28221|Deltaproteobacteria	S	Copper type II ascorbate-dependent monooxygenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Cu2_monoox_C
CMS3_k127_7490753_0	1123242.JH636436_gene461	2.338e-156	521.0	COG2010@1|root,COG2010@2|Bacteria,2IXIX@203682|Planctomycetes	203682|Planctomycetes	C	PFAM PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,DUF1080,PA14
CMS3_k127_7492263_1	378806.STAUR_5008	4.925e-19	93.0	2AJ6B@1|root,319R1@2|Bacteria,1Q3NG@1224|Proteobacteria,439FP@68525|delta/epsilon subdivisions,2X4RB@28221|Deltaproteobacteria,2YZFK@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7492263_0	502025.Hoch_3557	1.94e-66	236.0	COG0457@1|root,COG0457@2|Bacteria	502025.Hoch_3557|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7492263_2	502025.Hoch_3558	2.267e-14	83.0	COG1426@1|root,COG1426@2|Bacteria,1NIQS@1224|Proteobacteria,4387Z@68525|delta/epsilon subdivisions,2X3HR@28221|Deltaproteobacteria,2YW5H@29|Myxococcales	28221|Deltaproteobacteria	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_25
CMS3_k127_7492263_3	502025.Hoch_3559	1.387e-11	75.0	COG1381@1|root,COG1381@2|Bacteria,1RIBW@1224|Proteobacteria,42PUE@68525|delta/epsilon subdivisions,2WK4W@28221|Deltaproteobacteria,2YVXU@29|Myxococcales	28221|Deltaproteobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
CMS3_k127_7494639_0	235909.GK2591	6.518e-110	366.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,4HBMW@91061|Bacilli,1WFMJ@129337|Geobacillus	91061|Bacilli	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
CMS3_k127_7494639_1	1123242.JH636437_gene6023	7.177e-13	81.0	COG2385@1|root,COG2385@2|Bacteria,2J08W@203682|Planctomycetes	203682|Planctomycetes	D	Stage II sporulation protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
CMS3_k127_7496268_2	1121403.AUCV01000029_gene2721	3.222e-07	63.0	COG4861@1|root,COG4861@2|Bacteria,1RFGZ@1224|Proteobacteria,43032@68525|delta/epsilon subdivisions,2WVEI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transcriptional regulator, AbiEi antitoxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_2
CMS3_k127_7496268_0	1121403.AUCV01000010_gene1331	1.635e-114	385.0	COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2WJ4C@28221|Deltaproteobacteria,2MIGE@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	1.21.98.1,2.5.1.120,2.5.1.77	ko:K11779,ko:K11784,ko:K18285	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396,R10667	RC00021,RC01381,RC02329,RC03002,RC03007,RC03234	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3391	Radical_SAM
CMS3_k127_7496268_1	575540.Isop_1165	1.51e-26	111.0	COG1060@1|root,COG1060@2|Bacteria,2IX1I@203682|Planctomycetes	203682|Planctomycetes	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
CMS3_k127_7496806_4	1526927.Plano_2261	2.207e-29	136.0	COG1215@1|root,COG1215@2|Bacteria,1UI1V@1239|Firmicutes,4ISB6@91061|Bacilli,26G60@186818|Planococcaceae	91061|Bacilli	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_7496806_2	234267.Acid_4640	2.889e-104	347.0	COG1682@1|root,COG1682@2|Bacteria,3Y7JV@57723|Acidobacteria	57723|Acidobacteria	GM	ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
CMS3_k127_7496806_1	251229.Chro_2369	8.284e-114	384.0	COG1134@1|root,COG1134@2|Bacteria,1G28R@1117|Cyanobacteria,3VIKU@52604|Pleurocapsales	1117|Cyanobacteria	GM	ABC-type polysaccharide polyol phosphate transport system ATPase component	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
CMS3_k127_7496806_5	391037.Sare_2282	1.67e-28	132.0	COG2242@1|root,COG2242@2|Bacteria,2IAR0@201174|Actinobacteria,4D9FM@85008|Micromonosporales	201174|Actinobacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7496806_0	1499967.BAYZ01000014_gene6390	9.981e-121	402.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_7496806_3	32057.KB217478_gene1816	2.882e-50	186.0	COG0463@1|root,COG0463@2|Bacteria,1GPYG@1117|Cyanobacteria,1HUBJ@1161|Nostocales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_7500150_2	483219.LILAB_30070	3.176e-06	61.0	COG3485@1|root,COG3485@2|Bacteria,1QXUR@1224|Proteobacteria,43C7D@68525|delta/epsilon subdivisions,2X7HP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_7500150_1	313628.LNTAR_16187	2.255e-47	179.0	COG0740@1|root,COG0740@2|Bacteria	2|Bacteria	OU	serine-type endopeptidase activity	clpP3	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
CMS3_k127_7500150_0	944480.ATUV01000002_gene91	1.857e-69	246.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria,2M6MB@213113|Desulfurellales	28221|Deltaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
CMS3_k127_7502155_1	269797.Mbar_A1798	1.679e-09	71.0	COG1520@1|root,arCOG02496@1|root,arCOG02482@2157|Archaea,arCOG02496@2157|Archaea,arCOG02556@2157|Archaea,2XUI1@28890|Euryarchaeota,2NBKV@224756|Methanomicrobia	224756|Methanomicrobia	G	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NosD,PKD,PQQ_2,PQQ_3
CMS3_k127_7502155_2	62928.azo0278	0.0004424	53.0	2EFNF@1|root,339EK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7502333_0	497964.CfE428DRAFT_5315	1.922e-99	350.0	COG0457@1|root,COG0457@2|Bacteria,46UFP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7502333_1	1123242.JH636434_gene4185	4.463e-72	269.0	COG2425@1|root,COG2425@2|Bacteria,2IWXK@203682|Planctomycetes	203682|Planctomycetes	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7522508_3	933262.AXAM01000132_gene1919	1.215e-24	113.0	COG1762@1|root,COG1762@2|Bacteria,1RG0Z@1224|Proteobacteria,42RSF@68525|delta/epsilon subdivisions,2WNXB@28221|Deltaproteobacteria,2MJZ1@213118|Desulfobacterales	28221|Deltaproteobacteria	GT	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
CMS3_k127_7522508_0	177437.HRM2_16400	2.803e-117	408.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42PJQ@68525|delta/epsilon subdivisions,2WKR4@28221|Deltaproteobacteria,2MIMH@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
CMS3_k127_7522508_2	43989.cce_1643	1.562e-72	252.0	COG0778@1|root,COG0778@2|Bacteria,1G42X@1117|Cyanobacteria,3KJXS@43988|Cyanothece	1117|Cyanobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS3_k127_7522508_1	1173028.ANKO01000170_gene3367	3.029e-82	279.0	COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria,1H7AV@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
CMS3_k127_752251_5	323259.Mhun_2840	3.575e-15	87.0	COG3291@1|root,arCOG02516@1|root,arCOG03264@1|root,arCOG03606@1|root,arCOG02510@2157|Archaea,arCOG02516@2157|Archaea,arCOG03264@2157|Archaea,arCOG03606@2157|Archaea,2Y7RP@28890|Euryarchaeota,2NBKZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF3344,PKD
CMS3_k127_752251_4	289377.HL41_04990	4.73e-24	116.0	COG1463@1|root,COG1463@2|Bacteria,2GGR8@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
CMS3_k127_752251_1	215803.DB30_8598	2.899e-70	245.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NI4@68525|delta/epsilon subdivisions,2WKRT@28221|Deltaproteobacteria,2YZEX@29|Myxococcales	28221|Deltaproteobacteria	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
CMS3_k127_752251_2	243231.GSU1900	5.96e-48	181.0	COG0767@1|root,COG0767@2|Bacteria,1RHNJ@1224|Proteobacteria,42SNW@68525|delta/epsilon subdivisions,2WPKT@28221|Deltaproteobacteria,43T2D@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
CMS3_k127_752251_3	161156.JQKW01000014_gene220	5.112e-28	130.0	COG3170@1|root,COG3170@2|Bacteria,2GGY6@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_752251_0	909663.KI867150_gene894	2.781e-106	356.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,2MQAR@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
CMS3_k127_7525435_5	8010.XP_010889328.1	5.367e-06	48.0	COG3404@1|root,2QQBY@2759|Eukaryota,39SDR@33154|Opisthokonta,3BD2C@33208|Metazoa,3CSGV@33213|Bilateria,481PI@7711|Chordata,4959F@7742|Vertebrata,49QMG@7898|Actinopterygii	33208|Metazoa	E	Formiminotransferase cyclodeaminase	FTCD	GO:0000139,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005790,GO:0005793,GO:0005794,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0006996,GO:0007010,GO:0008017,GO:0008092,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0012505,GO:0015631,GO:0016020,GO:0016043,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0016829,GO:0016840,GO:0016841,GO:0019215,GO:0019439,GO:0019752,GO:0030407,GO:0030409,GO:0030412,GO:0030868,GO:0031090,GO:0031984,GO:0034641,GO:0042175,GO:0042558,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044877,GO:0046395,GO:0046483,GO:0046700,GO:0051186,GO:0052803,GO:0052805,GO:0071704,GO:0071840,GO:0071944,GO:0097425,GO:0098588,GO:0098791,GO:0098827,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.1.2.5,4.3.1.4	ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
CMS3_k127_7525435_0	459349.CLOAM0424	7.32e-103	350.0	COG1228@1|root,COG1228@2|Bacteria,2NNTC@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
CMS3_k127_7525435_4	283942.IL1391	6.25e-09	66.0	COG1595@1|root,COG1595@2|Bacteria,1RHRR@1224|Proteobacteria,1S2UD@1236|Gammaproteobacteria,2QFN4@267893|Idiomarinaceae	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigY	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_7525435_2	665571.STHERM_c00770	2.513e-33	148.0	COG2199@1|root,COG3706@2|Bacteria,2J8AQ@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GGDEF
CMS3_k127_7525435_1	373903.Hore_12560	3.175e-54	211.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3WAE6@53433|Halanaerobiales	186801|Clostridia	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
CMS3_k127_7525435_3	314230.DSM3645_07700	8.31e-16	87.0	COG1381@1|root,COG1381@2|Bacteria,2IZU9@203682|Planctomycetes	203682|Planctomycetes	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
CMS3_k127_7525435_6	316067.Geob_0758	0.0003578	52.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,42RV8@68525|delta/epsilon subdivisions,2WKU0@28221|Deltaproteobacteria,43UNU@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
CMS3_k127_7531741_1	289376.THEYE_A0125	9.997e-41	171.0	COG2770@1|root,COG4191@1|root,COG2770@2|Bacteria,COG4191@2|Bacteria,3J117@40117|Nitrospirae	40117|Nitrospirae	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP,HATPase_c,HisKA,PAS_4
CMS3_k127_7531741_0	1121456.ATVA01000018_gene397	3.406e-103	357.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJF9@28221|Deltaproteobacteria,2M8WX@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_7531815_0	1280954.HPO_14436	1.425e-69	253.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2TR2R@28211|Alphaproteobacteria,43XAN@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	penicillin-binding protein 1C	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
CMS3_k127_7531815_1	596152.DesU5LDRAFT_2703	6.575e-48	192.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,42MJ8@68525|delta/epsilon subdivisions,2WJF3@28221|Deltaproteobacteria,2M98U@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM alpha-2-macroglobulin domain protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl
CMS3_k127_7536244_2	105420.BBPO01000074_gene4404	2.121e-17	97.0	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria,2NFT6@228398|Streptacidiphilus	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	fbpB	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
CMS3_k127_7536244_0	765912.Thimo_1760	1.126e-82	290.0	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,1RQ6Z@1236|Gammaproteobacteria,1WWM0@135613|Chromatiales	135613|Chromatiales	P	extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
CMS3_k127_7536244_1	880073.Calab_3577	2.459e-44	181.0	COG3848@1|root,COG3848@2|Bacteria	2|Bacteria	GT	kinase activity	-	-	2.7.3.13,2.7.9.1,2.7.9.2	ko:K01006,ko:K01007,ko:K22424	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1080,PEP-utilizers,PPDK_N
CMS3_k127_7558390_3	1111479.AXAR01000009_gene2480	2.178e-06	49.0	COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,4HBGP@91061|Bacilli,277WP@186823|Alicyclobacillaceae	91061|Bacilli	H	ThiF family	moeB	-	2.7.7.73,2.7.7.80	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
CMS3_k127_7558390_2	314230.DSM3645_23261	6.493e-46	177.0	28I0W@1|root,30QX6@2|Bacteria,2IZI8@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7558390_0	1210884.HG799474_gene15166	3.548e-91	321.0	COG0116@1|root,COG0116@2|Bacteria,2IX2D@203682|Planctomycetes	203682|Planctomycetes	L	THUMP	-	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	Methyltrans_SAM,THUMP,UPF0020
CMS3_k127_7558390_1	661087.HMPREF1008_01431	2.423e-74	264.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,4CV16@84998|Coriobacteriia	84998|Coriobacteriia	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_7562576_0	1379698.RBG1_1C00001G0513	4.839e-109	363.0	COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
CMS3_k127_7562576_1	448385.sce9261	5.967e-106	361.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42NDT@68525|delta/epsilon subdivisions,2WNH1@28221|Deltaproteobacteria,2Z329@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
CMS3_k127_7562576_3	1003200.AXXA_06148	2.42e-45	181.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria	28216|Betaproteobacteria	T	response regulator	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_7562576_4	1219035.NT2_05_03090	6.009e-41	160.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,2K1VU@204457|Sphingomonadales	204457|Sphingomonadales	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS3_k127_7562576_2	1131269.AQVV01000007_gene1004	3.716e-64	227.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_7562576_5	215803.DB30_8034	3.075e-23	117.0	COG4932@1|root,COG4932@2|Bacteria,1NXIX@1224|Proteobacteria,430KM@68525|delta/epsilon subdivisions,2WVSB@28221|Deltaproteobacteria,2YYGY@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_7582589_1	1129794.C427_1223	3.232e-51	197.0	COG2706@1|root,COG3391@1|root,COG3637@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,COG3637@2|Bacteria,1QWRQ@1224|Proteobacteria,1T4S3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7582589_2	373994.Riv7116_6109	1.064e-24	122.0	COG1262@1|root,COG1262@2|Bacteria,1GIT1@1117|Cyanobacteria,1HJGE@1161|Nostocales	1117|Cyanobacteria	K	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS3_k127_7582589_0	886293.Sinac_7483	2.121e-97	356.0	COG0515@1|root,COG0515@2|Bacteria,2IYTQ@203682|Planctomycetes	203682|Planctomycetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16
CMS3_k127_7582589_3	195250.CM001776_gene4005	0.0006436	46.0	COG0457@1|root,COG0457@2|Bacteria,1G31A@1117|Cyanobacteria	1117|Cyanobacteria	S	tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
CMS3_k127_7590461_2	452637.Oter_0997	1.113e-16	85.0	2FEB0@1|root,346AT@2|Bacteria,46W5M@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7590461_0	530564.Psta_1355	1.894e-52	210.0	COG3568@1|root,COG3568@2|Bacteria,2IXGB@203682|Planctomycetes	203682|Planctomycetes	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS3_k127_7590461_1	1246484.D479_19608	9.436e-23	115.0	COG1621@1|root,COG1621@2|Bacteria,1TS4M@1239|Firmicutes,4HC82@91061|Bacilli,3NFQ5@45667|Halobacillus	91061|Bacilli	G	COG1621 Beta-fructosidases (levanase invertase)	-	-	3.2.1.80	ko:K03332	ko00051,map00051	-	R00879	-	ko00000,ko00001,ko01000	-	-	-	Big_2,CW_binding_1,Cadherin-like,Glyco_hydro_32C,Glyco_hydro_32N
CMS3_k127_7590461_3	1121396.KB892957_gene3262	1.52e-16	94.0	COG3322@1|root,COG4585@1|root,COG3322@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42RUN@68525|delta/epsilon subdivisions,2WMXF@28221|Deltaproteobacteria,2MJMS@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HATPase_c,HisKA_3
CMS3_k127_7590955_0	1172186.KB911470_gene3037	5.807e-41	167.0	COG4122@1|root,COG4122@2|Bacteria,2GNMM@201174|Actinobacteria,238WV@1762|Mycobacteriaceae	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
CMS3_k127_7590955_1	243090.RB3956	4.885e-10	66.0	COG3119@1|root,COG3119@2|Bacteria,2IXG7@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
CMS3_k127_7599370_0	357808.RoseRS_2140	9.551e-14	83.0	COG0457@1|root,COG0457@2|Bacteria,2G770@200795|Chloroflexi,374ST@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
CMS3_k127_7599370_1	1121456.ATVA01000011_gene1385	3.75e-11	75.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2M7YQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the peptidase S1C family	degP	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_7599370_2	50452.A0A087HPP0	1.946e-09	70.0	COG0526@1|root,KOG0907@2759|Eukaryota,37UQH@33090|Viridiplantae	33090|Viridiplantae	O	Belongs to the thioredoxin family	ATTRX4	GO:0003674,GO:0003824,GO:0004791,GO:0004857,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009636,GO:0009987,GO:0010496,GO:0010497,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0030234,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043086,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0097237,GO:0098754,GO:0098772,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS3_k127_76060_6	1340493.JNIF01000004_gene146	9.512e-53	198.0	COG1999@1|root,COG1999@2|Bacteria,3Y3XH@57723|Acidobacteria	57723|Acidobacteria	S	signal sequence binding	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
CMS3_k127_76060_7	765420.OSCT_2594	8.07e-10	66.0	2EJZ3@1|root,33DPP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_76060_2	1128421.JAGA01000003_gene2874	9.128e-105	357.0	COG4531@1|root,COG4531@2|Bacteria,2NP5Y@2323|unclassified Bacteria	2|Bacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	actF	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_76060_4	234267.Acid_0493	1.802e-58	217.0	COG2010@1|root,COG2010@2|Bacteria,3Y2MN@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
CMS3_k127_76060_5	1128421.JAGA01000003_gene2872	1.889e-53	217.0	COG2010@1|root,COG2010@2|Bacteria,2NPSE@2323|unclassified Bacteria	2|Bacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
CMS3_k127_76060_1	1128421.JAGA01000003_gene2871	7.487e-194	654.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	nrfD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
CMS3_k127_76060_0	1128421.JAGA01000003_gene2870	1.5e-323	1028.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hmeA	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molydop_binding
CMS3_k127_76060_3	886293.Sinac_3667	5.812e-95	315.0	COG3880@1|root,COG3880@2|Bacteria,2IYYJ@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
CMS3_k127_7614030_0	344747.PM8797T_13690	6.86e-258	810.0	COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,2IWZA@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type multidrug transport system ATPase component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3,ABC_tran
CMS3_k127_7614030_1	344747.PM8797T_13685	3.927e-93	320.0	COG0845@1|root,COG0845@2|Bacteria,2IYMS@203682|Planctomycetes	203682|Planctomycetes	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS3_k127_7614030_2	530564.Psta_1917	9.231e-68	250.0	COG4099@1|root,COG4099@2|Bacteria,2IZFN@203682|Planctomycetes	203682|Planctomycetes	S	Phospholipase/Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
CMS3_k127_7614030_3	1123508.JH636441_gene3444	4.263e-63	236.0	COG2755@1|root,COG2755@2|Bacteria,2J0Y1@203682|Planctomycetes	203682|Planctomycetes	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS3_k127_7618773_1	404589.Anae109_3694	1.823e-08	67.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,42P5H@68525|delta/epsilon subdivisions,2WKAU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_4,TPR_6,TPR_7,TPR_8
CMS3_k127_7618773_0	1379698.RBG1_1C00001G0054	4.184e-178	568.0	COG2502@1|root,COG2502@2|Bacteria,2NNKP@2323|unclassified Bacteria	2|Bacteria	E	Aspartate-ammonia ligase	asnA	GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	-	R00483	RC00010	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299	AsnA
CMS3_k127_7628855_1	1121087.AUCK01000001_gene3043	5.609e-41	164.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,1ZDBF@1386|Bacillus	91061|Bacilli	L	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS3_k127_7628855_2	1385511.N783_13840	3.12e-21	102.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,4HIR4@91061|Bacilli,2YACH@289201|Pontibacillus	91061|Bacilli	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
CMS3_k127_7628855_0	243090.RB8748	4.836e-89	303.0	COG0167@1|root,COG0167@2|Bacteria,2IX71@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.1,1.3.1.14	ko:K17723,ko:K17828	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046,M00051	R00977,R01414,R01869,R11026	RC00051,RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
CMS3_k127_7628855_3	68260.JOAY01000038_gene2315	4.695e-18	94.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	mprA	-	-	ko:K07669,ko:K07672	ko02020,map02020	M00460,M00463	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_765579_1	1229276.DI53_1225	2.47e-09	66.0	COG2866@1|root,COG2866@2|Bacteria,4NHBS@976|Bacteroidetes,1IV9B@117747|Sphingobacteriia	976|Bacteroidetes	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS3_k127_765579_0	649349.Lbys_0650	5.098e-138	459.0	COG2866@1|root,COG2866@2|Bacteria,4NH4I@976|Bacteroidetes,47MEA@768503|Cytophagia	976|Bacteroidetes	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS3_k127_768186_0	886293.Sinac_2881	1.514e-24	106.0	COG1506@1|root,COG1506@2|Bacteria,2J2M4@203682|Planctomycetes	203682|Planctomycetes	E	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
CMS3_k127_768487_0	595460.RRSWK_02101	4.611e-57	228.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes	203682|Planctomycetes	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,WD40
CMS3_k127_768487_2	1144275.COCOR_02191	1.122e-06	58.0	COG1595@1|root,COG1595@2|Bacteria,1N298@1224|Proteobacteria	1224|Proteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
CMS3_k127_768487_1	886293.Sinac_1635	9.307e-18	87.0	COG0582@1|root,COG0582@2|Bacteria,2IYXX@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
CMS3_k127_768487_3	465817.ETA_07890	0.0002986	51.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,3X4NG@551|Erwinia	1236|Gammaproteobacteria	U	general secretion pathway protein	gspG	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
CMS3_k127_769839_0	158500.BV97_01215	4.9e-30	138.0	COG4249@1|root,COG4249@2|Bacteria,1MXS7@1224|Proteobacteria,2TUXE@28211|Alphaproteobacteria,2KBKW@204457|Sphingomonadales	204457|Sphingomonadales	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
CMS3_k127_777228_0	886293.Sinac_5718	8.964e-159	514.0	COG3119@1|root,COG3119@2|Bacteria,2IYNT@203682|Planctomycetes	203682|Planctomycetes	P	Sulfatase	-	-	3.1.6.12	ko:K01135	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00076,M00077	R07823	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
CMS3_k127_777228_1	518766.Rmar_1357	2.029e-70	253.0	COG1680@1|root,COG1680@2|Bacteria,4NJ0F@976|Bacteroidetes	976|Bacteroidetes	V	Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_777228_2	867845.KI911784_gene2277	8.059e-15	83.0	COG0457@1|root,COG1404@1|root,COG3055@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,COG3055@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
CMS3_k127_777509_1	1267535.KB906767_gene447	2e-133	443.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria,2JMN2@204432|Acidobacteriia	204432|Acidobacteriia	T	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
CMS3_k127_777509_3	1403819.BATR01000090_gene2633	1.811e-71	265.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Calx-beta,DUF1080,F5_F8_type_C,PA14
CMS3_k127_777509_0	314230.DSM3645_26339	1.09e-167	547.0	COG2755@1|root,COG2755@2|Bacteria,2IYT9@203682|Planctomycetes	203682|Planctomycetes	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,Lipase_GDSL_2
CMS3_k127_777509_5	1129794.C427_1223	1.227e-40	170.0	COG2706@1|root,COG3391@1|root,COG3637@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,COG3637@2|Bacteria,1QWRQ@1224|Proteobacteria,1T4S3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_777509_2	886293.Sinac_3618	1.385e-87	325.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
CMS3_k127_777509_4	1123508.JH636453_gene5810	6.377e-48	181.0	COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
CMS3_k127_777509_6	864051.BurJ1DRAFT_0027	2.055e-07	63.0	COG1404@1|root,COG1572@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,1MU3S@1224|Proteobacteria,2VZPE@28216|Betaproteobacteria	28216|Betaproteobacteria	M	CARDB domain-containing protein,subtilase family protease	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Peptidase_S8
CMS3_k127_786807_0	521674.Plim_1809	6.448e-69	263.0	COG0265@1|root,COG0265@2|Bacteria,2IXA0@203682|Planctomycetes	203682|Planctomycetes	O	peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_786807_1	886293.Sinac_3975	1.491e-22	112.0	COG0810@1|root,COG0810@2|Bacteria,2IZYP@203682|Planctomycetes	203682|Planctomycetes	M	carbohydrate binding	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM
CMS3_k127_786807_2	1123508.JH636443_gene4858	3.407e-12	78.0	29G09@1|root,302Y2@2|Bacteria,2IZ7F@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_786807_3	521674.Plim_1806	7.964e-08	65.0	COG3147@1|root,COG3147@2|Bacteria,2IYA2@203682|Planctomycetes	203682|Planctomycetes	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_788159_0	391037.Sare_3462	5.311e-100	338.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4D8ZI@85008|Micromonosporales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
CMS3_k127_788437_1	240016.ABIZ01000001_gene943	5.71e-46	182.0	COG0577@1|root,COG0577@2|Bacteria,46TM1@74201|Verrucomicrobia,2IVW0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	MacB_PCD
CMS3_k127_788437_0	1342302.JASC01000002_gene73	1.916e-69	248.0	COG1136@1|root,COG1136@2|Bacteria,1RA1K@1224|Proteobacteria,2U7CA@28211|Alphaproteobacteria,3ZUVZ@60136|Sulfitobacter	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_788437_2	1123070.KB899247_gene1446	1.431e-39	169.0	2ECB1@1|root,3369C@2|Bacteria,46WPZ@74201|Verrucomicrobia,2IW2Q@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_788437_3	237368.SCABRO_02891	3.844e-13	83.0	COG2370@1|root,COG2370@2|Bacteria,2J0KW@203682|Planctomycetes	203682|Planctomycetes	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
CMS3_k127_790464_1	1210884.HG799466_gene12530	9.059e-53	192.0	COG3345@1|root,COG3345@2|Bacteria,2IZER@203682|Planctomycetes	203682|Planctomycetes	G	Carbohydrate esterase, sialic acid-specific acetylesterase	-	-	-	-	-	-	-	-	-	-	-	-	SASA
CMS3_k127_790464_0	1192034.CAP_5903	1.788e-78	279.0	2DNQQ@1|root,32YKT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
CMS3_k127_790464_2	1121272.KB903249_gene2198	2.3e-25	113.0	COG1501@1|root,COG4412@1|root,COG1501@2|Bacteria,COG4412@2|Bacteria,2GP4V@201174|Actinobacteria,4DM37@85008|Micromonosporales	201174|Actinobacteria	G	Domain of unknown function (DUF4968)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4968,DUF5110,F5_F8_type_C,FIVAR,Glyco_hydro_31,Ricin_B_lectin
CMS3_k127_806381_1	1121904.ARBP01000018_gene2643	3.433e-15	86.0	COG5295@1|root,COG5295@2|Bacteria,4PHWW@976|Bacteroidetes,47ST5@768503|Cytophagia	976|Bacteroidetes	UW	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_806381_0	1123508.JH636439_gene519	9.566e-21	95.0	COG1520@1|root,COG1520@2|Bacteria,2IWR8@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_807925_1	1306174.JODP01000009_gene6471	3.225e-22	102.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
CMS3_k127_807925_0	595460.RRSWK_03606	2.196e-80	277.0	COG3119@1|root,COG3119@2|Bacteria,2IWSZ@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_808906_2	197221.22295970	2.775e-20	101.0	COG0631@1|root,COG0631@2|Bacteria,1G2FY@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM protein phosphatase 2C	pphA	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
CMS3_k127_808906_0	344747.PM8797T_13483	7.966e-86	299.0	COG1459@1|root,COG1459@2|Bacteria,2IX2A@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway component PulF	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
CMS3_k127_808906_1	1125863.JAFN01000001_gene2936	4.527e-31	139.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02668,ko:K07710	ko02020,map02020	M00500,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
CMS3_k127_808906_3	756272.Plabr_2448	0.0009538	45.0	COG1253@1|root,COG1253@2|Bacteria,2IZ76@203682|Planctomycetes	203682|Planctomycetes	S	Hemolysin protein	-	-	-	-	-	-	-	-	-	-	-	-	CorC_HlyC,DUF21
CMS3_k127_809038_1	1301100.HG529445_gene4798	2.535e-08	55.0	2BF07@1|root,328RY@2|Bacteria,1UUQA@1239|Firmicutes,257FN@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_809038_0	1178825.ALIH01000016_gene630	6.745e-35	139.0	COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,1HWM1@117743|Flavobacteriia	976|Bacteroidetes	M	Membrane protein involved in D-alanine export	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
CMS3_k127_811994_6	1123508.JH636440_gene2102	6.944e-09	59.0	COG3000@1|root,COG3000@2|Bacteria,2J12U@203682|Planctomycetes	203682|Planctomycetes	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
CMS3_k127_811994_0	530564.Psta_1647	1.594e-199	653.0	COG1686@1|root,COG2367@1|root,COG3409@1|root,COG1686@2|Bacteria,COG2367@2|Bacteria,COG3409@2|Bacteria,2IY9N@203682|Planctomycetes	203682|Planctomycetes	M	PFAM peptidase S11 D-alanyl-D-alanine carboxypeptidase	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Beta-lactamase2,PG_binding_1,Peptidase_S11
CMS3_k127_811994_3	983917.RGE_13030	1.843e-45	169.0	COG0454@1|root,COG0454@2|Bacteria,1QUHE@1224|Proteobacteria,2VTMP@28216|Betaproteobacteria,1KNRR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K03829	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
CMS3_k127_811994_7	1313172.YM304_12480	1.065e-08	68.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_811994_2	1123508.JH636443_gene5010	9.896e-47	194.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
CMS3_k127_811994_1	251221.35214774	3.35e-102	364.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,TIG,VCBS
CMS3_k127_811994_5	1348663.KCH_08930	2.769e-14	87.0	COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria,2M55N@2063|Kitasatospora	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,Peptidase_S8
CMS3_k127_811994_4	459349.CLOAM0774	5.326e-39	165.0	COG3016@1|root,COG3016@2|Bacteria,2NRWX@2323|unclassified Bacteria	2|Bacteria	S	Haem-binding uptake, Tiki superfamily, ChaN	phuW	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
CMS3_k127_813159_2	1248917.ANFX01000034_gene657	1.889e-08	67.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2K04M@204457|Sphingomonadales	204457|Sphingomonadales	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16,TPR_19,TPR_8
CMS3_k127_813159_1	936136.ARRT01000007_gene1325	1.425e-11	78.0	COG2931@1|root,COG4249@1|root,COG2931@2|Bacteria,COG4249@2|Bacteria,1R3SZ@1224|Proteobacteria,2TVR0@28211|Alphaproteobacteria,4B96N@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Caspase domain	MA20_39250	-	-	-	-	-	-	-	-	-	-	-	Lectin_C,PG_binding_1,Peptidase_C14
CMS3_k127_813159_0	391598.FBBAL38_09852	1.103e-129	440.0	COG1520@1|root,COG1520@2|Bacteria,4NHPR@976|Bacteroidetes,1HXXS@117743|Flavobacteriia	976|Bacteroidetes	G	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans
CMS3_k127_813421_0	639030.JHVA01000001_gene3381	8.759e-26	118.0	2B33H@1|root,31VR5@2|Bacteria,3Y819@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_813579_0	530564.Psta_2741	0.0	1154.0	COG0376@1|root,COG0376@2|Bacteria,2IY35@203682|Planctomycetes	203682|Planctomycetes	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
CMS3_k127_813579_1	469383.Cwoe_2725	1.197e-53	192.0	COG0735@1|root,COG0735@2|Bacteria,2IFBR@201174|Actinobacteria,4CTCG@84995|Rubrobacteria	84995|Rubrobacteria	P	Ferric uptake regulator family	-	-	-	ko:K22297	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS3_k127_813579_2	1123508.JH636439_gene1297	2.014e-05	52.0	COG1595@1|root,COG1595@2|Bacteria,2IZFC@203682|Planctomycetes	203682|Planctomycetes	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ECF,Sigma70_r2,Sigma70_r4_2
CMS3_k127_816229_1	1142394.PSMK_03840	2.717e-44	176.0	COG0592@1|root,COG0592@2|Bacteria,2IY9S@203682|Planctomycetes	203682|Planctomycetes	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
CMS3_k127_816229_0	1125863.JAFN01000001_gene2637	1.723e-217	704.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
CMS3_k127_816229_2	398767.Glov_1638	3.499e-07	59.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42P9Y@68525|delta/epsilon subdivisions,2WM6A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	General secretory system II protein E domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,T2SSE,T2SSE_N
CMS3_k127_816383_2	1403819.BATR01000102_gene3401	5.068e-29	129.0	COG0736@1|root,COG0736@2|Bacteria,46T5U@74201|Verrucomicrobia,2IUTE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	4'-phosphopantetheinyl transferase superfamily	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
CMS3_k127_816383_0	118173.KB235910_gene4793	1.127e-67	238.0	COG1940@1|root,COG1940@2|Bacteria,1G0YU@1117|Cyanobacteria,1H786@1150|Oscillatoriales	1117|Cyanobacteria	GK	Transcriptional regulator sugar kinase	ppgK	-	2.7.1.63	ko:K00886	ko00010,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R02187,R02189	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
CMS3_k127_816383_1	575540.Isop_3307	1.144e-56	206.0	COG1446@1|root,COG1446@2|Bacteria,2IZ4V@203682|Planctomycetes	203682|Planctomycetes	E	PFAM peptidase T2 asparaginase 2	-	-	3.4.19.5,3.5.1.26	ko:K01444,ko:K13051	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Asparaginase_2,DUF4440
CMS3_k127_818334_1	1296416.JACB01000004_gene1133	4.42e-39	156.0	COG1988@1|root,COG1988@2|Bacteria,4NPMW@976|Bacteroidetes,1I2P2@117743|Flavobacteriia,2YIQT@290174|Aquimarina	976|Bacteroidetes	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
CMS3_k127_818334_2	1379698.RBG1_1C00001G0272	2.711e-38	155.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,DUF2505
CMS3_k127_818334_0	1304275.C41B8_05113	5.153e-49	181.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,1S6HB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS3_k127_818334_3	393595.ABO_0924	8.188e-07	62.0	COG0438@1|root,COG0438@2|Bacteria,1N0DG@1224|Proteobacteria,1S0D6@1236|Gammaproteobacteria,1XKXB@135619|Oceanospirillales	135619|Oceanospirillales	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glycos_transf_1
CMS3_k127_820877_0	382464.ABSI01000006_gene852	0.0	1225.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	preT	-	1.2.7.1	ko:K00171,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_6,PFOR_II,POR,POR_N,Pyr_redox_2,Pyr_redox_3,TPP_enzyme_C
CMS3_k127_820877_1	404589.Anae109_3838	5.996e-16	84.0	COG1409@1|root,COG1409@2|Bacteria,1NS3S@1224|Proteobacteria,43AFC@68525|delta/epsilon subdivisions,2X64J@28221|Deltaproteobacteria,2Z0UN@29|Myxococcales	28221|Deltaproteobacteria	G	Purple acid Phosphatase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
CMS3_k127_820987_1	575540.Isop_1644	1.12e-206	687.0	COG0265@1|root,COG3266@1|root,COG4447@1|root,COG0265@2|Bacteria,COG3266@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	3.2.1.4,3.4.21.107	ko:K01179,ko:K04771	ko00500,ko01100,ko01503,ko02020,map00500,map01100,map01503,map02020	M00728	R06200,R11307,R11308	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	GH5,GH9	-	PDZ_2,Sortilin-Vps10,Trypsin_2
CMS3_k127_820987_0	1121104.AQXH01000002_gene717	5.479e-217	725.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,1IW7V@117747|Sphingobacteriia	976|Bacteroidetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
CMS3_k127_83043_2	1172181.KB911708_gene8102	5.624e-08	61.0	COG1595@1|root,COG1595@2|Bacteria,2GJER@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_83043_0	761193.Runsl_0200	1.072e-13	84.0	COG0823@1|root,COG2885@1|root,COG3063@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,COG3063@2|Bacteria,4NE6G@976|Bacteroidetes,47MTM@768503|Cytophagia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
CMS3_k127_83043_1	530564.Psta_2467	1.996e-08	57.0	COG0810@1|root,COG1657@1|root,COG0810@2|Bacteria,COG1657@2|Bacteria,2IYCT@203682|Planctomycetes	203682|Planctomycetes	I	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
CMS3_k127_839395_2	469383.Cwoe_1586	4.647e-34	137.0	COG4861@1|root,COG4861@2|Bacteria,2GMDQ@201174|Actinobacteria,4CTNZ@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_839395_1	929712.KI912613_gene1718	4.187e-52	198.0	2AN1K@1|root,31CYZ@2|Bacteria,2I8YS@201174|Actinobacteria,4CSY3@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_839395_0	886293.Sinac_1552	1.336e-73	265.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2IXHK@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
CMS3_k127_839395_3	29540.C481_17845	1.027e-10	63.0	COG0805@1|root,arCOG04736@2157|Archaea,2XU1A@28890|Euryarchaeota,23SVM@183963|Halobacteria	183963|Halobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	-	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
CMS3_k127_847954_1	1144275.COCOR_07912	0.0007782	52.0	COG4932@1|root,COG4932@2|Bacteria,1R5S8@1224|Proteobacteria	1224|Proteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_847954_0	195105.CN97_12195	1.734e-28	129.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane protein (homolog of Drosophila rhomboid)	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS3_k127_851857_0	204669.Acid345_0472	2.338e-109	382.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII,Cytochrom_c3_2,Cytochrome_C7
CMS3_k127_851857_1	880073.Calab_3330	5.889e-104	365.0	COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,2NS2I@2323|unclassified Bacteria	2|Bacteria	O	Pyridine nucleotide-disulphide oxidoreductase	trxB_2	-	1.18.1.2,1.19.1.1,1.8.1.9	ko:K00384,ko:K21567	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,Pyr_redox_3
CMS3_k127_851857_3	1125863.JAFN01000001_gene318	3.139e-15	91.0	COG2010@1|root,COG2010@2|Bacteria,1QZNA@1224|Proteobacteria,43CM3@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
CMS3_k127_851857_2	269799.Gmet_0576	6.828e-81	305.0	COG4386@1|root,COG4733@1|root,COG4386@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Malectin,NPCBM,Phage-tail_3,fn3
CMS3_k127_858928_0	338963.Pcar_0553	1.784e-140	465.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2WJ76@28221|Deltaproteobacteria,43S4V@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	GIY-YIG type nucleases (URI domain)	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
CMS3_k127_858928_1	641526.ADIWIN_2984	1.102e-18	93.0	2DM9Y@1|root,32AJ6@2|Bacteria,4NQQC@976|Bacteroidetes,1I336@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_861570_2	105425.BBPL01000001_gene6101	2.308e-08	63.0	COG1486@1|root,COG1486@2|Bacteria,2GK80@201174|Actinobacteria,2NKWZ@228398|Streptacidiphilus	201174|Actinobacteria	G	Family 4 glycosyl hydrolase	-	-	3.2.1.86	ko:K01222	ko00010,ko00500,map00010,map00500	-	R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
CMS3_k127_861570_1	1121451.DESAM_23095	8.5e-35	151.0	COG0535@1|root,COG0535@2|Bacteria,1RG5U@1224|Proteobacteria,42RKR@68525|delta/epsilon subdivisions,2WNUX@28221|Deltaproteobacteria,2MAGK@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
CMS3_k127_861570_0	1242864.D187_007839	8.588e-79	273.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
CMS3_k127_869446_2	1121920.AUAU01000004_gene745	2.698e-39	154.0	COG0506@1|root,COG0506@2|Bacteria,3Y2G8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
CMS3_k127_869446_0	357808.RoseRS_4428	8.851e-106	365.0	COG0399@1|root,COG0399@2|Bacteria,2G7J4@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS3_k127_869446_1	391625.PPSIR1_24609	5.103e-66	236.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,42MXK@68525|delta/epsilon subdivisions,2WKEJ@28221|Deltaproteobacteria,2YZ1K@29|Myxococcales	28221|Deltaproteobacteria	IQ	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II,adh_short,adh_short_C2
CMS3_k127_883674_0	756272.Plabr_1950	2.103e-05	55.0	COG1413@1|root,COG3391@1|root,COG1413@2|Bacteria,COG3391@2|Bacteria,2IXTT@203682|Planctomycetes	203682|Planctomycetes	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS3_k127_883674_1	483219.LILAB_28760	0.0004688	46.0	COG4932@1|root,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,43CJR@68525|delta/epsilon subdivisions,2X7U3@28221|Deltaproteobacteria,2Z3HT@29|Myxococcales	28221|Deltaproteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_887875_6	1122179.KB890434_gene874	2.128e-15	89.0	COG4733@1|root,COG5276@1|root,COG4733@2|Bacteria,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1IYS6@117747|Sphingobacteriia	976|Bacteroidetes	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3
CMS3_k127_887875_4	289377.HL41_05445	8.957e-58	211.0	COG0087@1|root,COG0087@2|Bacteria,2GHBZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
CMS3_k127_887875_2	1123508.JH636442_gene4176	1.115e-76	274.0	COG2081@1|root,COG2081@2|Bacteria,2IWW4@203682|Planctomycetes	203682|Planctomycetes	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
CMS3_k127_887875_10	483219.LILAB_18790	0.0001591	56.0	COG4932@1|root,COG5184@1|root,COG4932@2|Bacteria,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	-	ko:K14475,ko:K20276	ko02024,ko05143,map02024,map05143	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,RCC1_2
CMS3_k127_887875_3	765911.Thivi_2354	3.756e-62	221.0	2AMYE@1|root,31CVH@2|Bacteria,1NT8E@1224|Proteobacteria,1SMY1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_887875_5	232348.ADXL01000063_gene2609	4.994e-50	188.0	COG4328@1|root,COG4328@2|Bacteria	2|Bacteria	Q	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF429,RelA_SpoT
CMS3_k127_887875_0	1121920.AUAU01000009_gene1896	6.347e-197	639.0	COG2183@1|root,COG2183@2|Bacteria,3Y2QM@57723|Acidobacteria	57723|Acidobacteria	K	SMART Resolvase, RNase H domain protein fold	-	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
CMS3_k127_887875_1	1380394.JADL01000001_gene2784	1.059e-132	432.0	COG0500@1|root,COG0500@2|Bacteria,1N3PV@1224|Proteobacteria,2TVNH@28211|Alphaproteobacteria,2JQZB@204441|Rhodospirillales	204441|Rhodospirillales	Q	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
CMS3_k127_887875_7	1121946.AUAX01000007_gene2799	1.068e-06	59.0	2D579@1|root,32QJ3@2|Bacteria,2IGSA@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_887875_8	936375.HMPREF1152_0404	0.0001189	52.0	COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,3WCJ6@538999|Clostridiales incertae sedis	186801|Clostridia	M	Domain present in PSD-95, Dlg, and ZO-1/2.	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
CMS3_k127_893346_4	604354.TSIB_0942	6.116e-76	280.0	COG1297@1|root,arCOG04807@2157|Archaea,2Y2AA@28890|Euryarchaeota,243VV@183968|Thermococci	183968|Thermococci	P	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
CMS3_k127_893346_1	388413.ALPR1_01110	2.086e-150	509.0	COG4188@1|root,COG4188@2|Bacteria,4NKC2@976|Bacteroidetes,47TN2@768503|Cytophagia	976|Bacteroidetes	S	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Chlorophyllase2
CMS3_k127_893346_9	717231.Flexsi_1740	7.102e-07	58.0	2DNS7@1|root,32YWC@2|Bacteria	2|Bacteria	S	S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
CMS3_k127_893346_2	485916.Dtox_2388	2.292e-129	425.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,2601M@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
CMS3_k127_893346_0	886293.Sinac_2238	1.488e-222	707.0	COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,2IXPK@203682|Planctomycetes	203682|Planctomycetes	J	Ribosomal protein S1	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
CMS3_k127_893346_8	997346.HMPREF9374_2495	2.301e-32	137.0	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,4HIJN@91061|Bacilli,27D2B@186824|Thermoactinomycetaceae	91061|Bacilli	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
CMS3_k127_893346_5	1267535.KB906767_gene3536	1.505e-47	181.0	COG0283@1|root,COG0283@2|Bacteria,3Y4MV@57723|Acidobacteria,2JJ7N@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
CMS3_k127_893346_3	575540.Isop_3482	5.561e-125	425.0	COG2204@1|root,COG2204@2|Bacteria,2IWYY@203682|Planctomycetes	203682|Planctomycetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_893346_7	404589.Anae109_0620	8.257e-41	160.0	COG4191@1|root,COG4191@2|Bacteria,1R5Q1@1224|Proteobacteria,42RPW@68525|delta/epsilon subdivisions,2WK10@28221|Deltaproteobacteria,2Z2WV@29|Myxococcales	28221|Deltaproteobacteria	T	HAMP domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,dCache_2
CMS3_k127_893346_6	530564.Psta_2583	1.071e-45	179.0	COG0009@1|root,COG0394@1|root,COG0009@2|Bacteria,COG0394@2|Bacteria,2IX5F@203682|Planctomycetes	203682|Planctomycetes	T	Belongs to the SUA5 family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc,Sua5_yciO_yrdC
CMS3_k127_90305_3	292459.STH2747	1.245e-53	214.0	COG1463@1|root,COG2120@1|root,COG1463@2|Bacteria,COG2120@2|Bacteria,1UYPV@1239|Firmicutes,251C1@186801|Clostridia	186801|Clostridia	Q	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS3_k127_90305_4	1142394.PSMK_12630	1.839e-05	58.0	2EUN2@1|root,33N3X@2|Bacteria,2J1AF@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_90305_0	1382304.JNIL01000001_gene2235	7.782e-97	342.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli,277VV@186823|Alicyclobacillaceae	91061|Bacilli	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
CMS3_k127_90305_2	105559.Nwat_1479	1.064e-64	236.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1WWHG@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS3_k127_90305_1	278963.ATWD01000002_gene340	7.84e-81	282.0	COG0438@1|root,COG0438@2|Bacteria,3Y3CI@57723|Acidobacteria,2JKK7@204432|Acidobacteriia	204432|Acidobacteriia	M	glycosyl transferase group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_903907_3	1499967.BAYZ01000139_gene144	6.946e-05	49.0	COG2199@1|root,COG3706@2|Bacteria,2NR9S@2323|unclassified Bacteria	2|Bacteria	T	Domain of unknown function (DUF4388)	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	CheX,HATPase_c,HisKA,Response_reg
CMS3_k127_903907_0	243090.RB10466	3.385e-19	94.0	COG0764@1|root,COG0764@2|Bacteria,2IZNA@203682|Planctomycetes	203682|Planctomycetes	I	3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein)	-	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
CMS3_k127_903907_2	443144.GM21_1641	8.203e-08	65.0	COG3014@1|root,COG3014@2|Bacteria	2|Bacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_903907_1	877455.Metbo_0195	9.653e-13	72.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,23NMT@183925|Methanobacteria	183925|Methanobacteria	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
CMS3_k127_909380_0	391625.PPSIR1_33953	1.832e-221	700.0	COG0457@1|root,COG0457@2|Bacteria,1P0DI@1224|Proteobacteria,431RN@68525|delta/epsilon subdivisions,2WWCP@28221|Deltaproteobacteria,2Z3IU@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_909380_1	391625.PPSIR1_33963	1.545e-156	503.0	COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,42TQ9@68525|delta/epsilon subdivisions,2WR3B@28221|Deltaproteobacteria,2YUXH@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
CMS3_k127_909648_1	1122176.KB903545_gene836	2.378e-07	55.0	COG1858@1|root,COG1858@2|Bacteria,4NJGU@976|Bacteroidetes,1J099@117747|Sphingobacteriia	976|Bacteroidetes	P	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
CMS3_k127_909648_0	717606.PaecuDRAFT_2033	3.637e-101	354.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,1UKER@1239|Firmicutes,4HFP1@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
CMS3_k127_913985_0	497964.CfE428DRAFT_0237	7.978e-30	138.0	2BMSD@1|root,32GBT@2|Bacteria,46VIR@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_916324_1	985665.HPL003_09345	0.0009151	52.0	COG1404@1|root,COG1621@1|root,COG1404@2|Bacteria,COG1621@2|Bacteria,1TPH1@1239|Firmicutes,4HBQH@91061|Bacilli,26SE7@186822|Paenibacillaceae	91061|Bacilli	O	Belongs to the peptidase S8 family	prtS	-	3.4.21.110,3.4.21.96	ko:K01361,ko:K08652	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	FIVAR,Gram_pos_anchor,Inhibitor_I9,PA,Peptidase_S8,SLH,YSIRK_signal,fn3_5
CMS3_k127_916324_0	215803.DB30_0795	3.764e-46	178.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,42T8M@68525|delta/epsilon subdivisions,2WPBS@28221|Deltaproteobacteria,2YW9W@29|Myxococcales	28221|Deltaproteobacteria	I	Serine aminopeptidase, S33	agmH	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS3_k127_9180_1	1408473.JHXO01000009_gene3486	2.697e-64	224.0	COG2148@1|root,COG2148@2|Bacteria,4NER4@976|Bacteroidetes,2FNC2@200643|Bacteroidia	976|Bacteroidetes	M	Psort location CytoplasmicMembrane, score	-	-	-	ko:K13012	-	-	-	-	ko00000,ko01005	-	-	-	Bac_transf,CoA_binding_3
CMS3_k127_9180_0	153948.NAL212_0248	1.043e-129	443.0	COG1061@1|root,COG1112@1|root,COG1061@2|Bacteria,COG1112@2|Bacteria,1MWMG@1224|Proteobacteria,2VHWC@28216|Betaproteobacteria,373ZI@32003|Nitrosomonadales	28216|Betaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF559
CMS3_k127_920020_0	1122138.AQUZ01000061_gene5268	2.672e-61	221.0	COG1309@1|root,COG1309@2|Bacteria,2GJES@201174|Actinobacteria,4DRI3@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_920020_1	497964.CfE428DRAFT_2363	2.441e-40	157.0	2DN6W@1|root,32UIF@2|Bacteria,46WNT@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_920020_2	592029.DDD_2718	0.0001151	52.0	2FF5R@1|root,3473U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_92132_0	1123377.AUIV01000003_gene1795	9.069e-79	280.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1X4MI@135614|Xanthomonadales	135614|Xanthomonadales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
CMS3_k127_92132_1	530564.Psta_0358	3.169e-35	136.0	COG4398@1|root,COG4398@2|Bacteria,2IXYT@203682|Planctomycetes	203682|Planctomycetes	S	PFAM FIST C domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
CMS3_k127_925567_2	402777.KB235903_gene1488	4.377e-61	217.0	COG1063@1|root,COG1063@2|Bacteria,1FZZE@1117|Cyanobacteria,1H7Y9@1150|Oscillatoriales	2|Bacteria	E	COG1063 Threonine dehydrogenase and related Zn-dependent	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_925567_0	1267533.KB906737_gene1841	1.661e-154	509.0	COG0367@1|root,COG0367@2|Bacteria	2|Bacteria	E	asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS3_k127_925567_4	1054860.KB913030_gene6184	1.266e-21	111.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_925567_3	1121015.N789_11245	1.027e-39	163.0	28IYZ@1|root,2Z8WJ@2|Bacteria,1N1QE@1224|Proteobacteria,1SQ03@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_925567_1	55952.BU52_33320	1.047e-96	355.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria	201174|Actinobacteria	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding
CMS3_k127_92726_2	1303518.CCALI_00276	3.456e-63	226.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC4_WD40,PD40,PSCyt1,WD40
CMS3_k127_92726_3	105422.BBPM01000097_gene5230	1.744e-06	59.0	COG3361@1|root,COG3361@2|Bacteria,2GKQC@201174|Actinobacteria,2NKXH@228398|Streptacidiphilus	201174|Actinobacteria	S	Uncharacterized conserved protein (COG2071)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2071
CMS3_k127_92726_1	1121904.ARBP01000016_gene5249	3.667e-81	285.0	COG0715@1|root,COG0715@2|Bacteria,4NH2X@976|Bacteroidetes,47JPM@768503|Cytophagia	976|Bacteroidetes	P	Protein of unknown function (DUF3500)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3500
CMS3_k127_92726_0	314230.DSM3645_24600	1.565e-199	631.0	COG4102@1|root,COG4102@2|Bacteria,2IX70@203682|Planctomycetes	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
CMS3_k127_933060_0	344747.PM8797T_08989	9.077e-39	164.0	2BP4B@1|root,32HV6@2|Bacteria,2IZUR@203682|Planctomycetes	203682|Planctomycetes	S	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_942413_7	983920.Y88_3527	9.76e-09	68.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2TT1Y@28211|Alphaproteobacteria,2K00D@204457|Sphingomonadales	204457|Sphingomonadales	D	protein involved in exopolysaccharide biosynthesis	-	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,Wzz
CMS3_k127_942413_2	290397.Adeh_2455	6.495e-83	295.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
CMS3_k127_942413_4	357808.RoseRS_4265	7.431e-47	192.0	COG1216@1|root,COG1216@2|Bacteria,2G7UG@200795|Chloroflexi,3764Q@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
CMS3_k127_942413_6	443143.GM18_0659	2.488e-34	146.0	COG0399@1|root,COG0399@2|Bacteria,1N5QZ@1224|Proteobacteria	1224|Proteobacteria	M	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS3_k127_942413_1	1117647.M5M_10885	1.448e-231	730.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,1J5GX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	alsS	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_942413_0	502025.Hoch_5291	9.843e-256	794.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria,2YU8H@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_942413_5	290397.Adeh_3956	7.564e-42	164.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_942413_3	1278073.MYSTI_05557	2.652e-53	195.0	COG0035@1|root,COG0035@2|Bacteria,1RBD6@1224|Proteobacteria,42R1E@68525|delta/epsilon subdivisions,2WN3Q@28221|Deltaproteobacteria,2YU4E@29|Myxococcales	28221|Deltaproteobacteria	F	Uracil phosphoribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	UPRTase
CMS3_k127_955365_1	768671.ThimaDRAFT_1547	1.523e-20	97.0	COG4122@1|root,COG4122@2|Bacteria,1NEYT@1224|Proteobacteria	1224|Proteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
CMS3_k127_955365_2	1223523.H340_05209	1.753e-15	90.0	COG0535@1|root,COG0535@2|Bacteria,2IF9S@201174|Actinobacteria	201174|Actinobacteria	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS3_k127_955365_0	344747.PM8797T_25351	3.17e-131	428.0	COG4654@1|root,COG4654@2|Bacteria,2IX0M@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PSCyt1,PSCyt2,PSD1
CMS3_k127_960349_2	290315.Clim_0859	1.53e-31	125.0	COG0302@1|root,COG0302@2|Bacteria,1FD81@1090|Chlorobi	1090|Chlorobi	F	PFAM GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
CMS3_k127_960349_4	1110502.TMO_1189	1.038e-14	78.0	COG3806@1|root,COG3806@2|Bacteria,1MZEX@1224|Proteobacteria,2UCQQ@28211|Alphaproteobacteria,2JZRY@204441|Rhodospirillales	204441|Rhodospirillales	T	ChrR Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
CMS3_k127_960349_1	575540.Isop_1658	3.407e-67	253.0	COG0202@1|root,COG0457@1|root,COG0202@2|Bacteria,COG0457@2|Bacteria,2IXMK@203682|Planctomycetes	203682|Planctomycetes	K	rna polymerase alpha	-	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,TPR_1,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
CMS3_k127_960349_3	1515746.HR45_11155	2.157e-28	124.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,2Q8WE@267890|Shewanellaceae	1236|Gammaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0000217,GO:0000400,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
CMS3_k127_960349_0	1247963.JPHU01000002_gene2728	5.456e-167	544.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
CMS3_k127_968802_3	1379698.RBG1_1C00001G0982	4.604e-12	74.0	COG0223@1|root,COG0223@2|Bacteria,2NP7J@2323|unclassified Bacteria	2|Bacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
CMS3_k127_968802_0	530564.Psta_1370	7.857e-100	338.0	28IRY@1|root,2Z8R6@2|Bacteria,2IWWT@203682|Planctomycetes	203682|Planctomycetes	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
CMS3_k127_968802_2	1268068.PG5_03630	2.429e-18	98.0	COG2832@1|root,COG2832@2|Bacteria,1N7BI@1224|Proteobacteria,1S9V2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
CMS3_k127_968802_1	665942.HMPREF1022_01299	3.189e-30	130.0	COG2230@1|root,COG2230@2|Bacteria,1NKE6@1224|Proteobacteria,432ND@68525|delta/epsilon subdivisions,2WXTJ@28221|Deltaproteobacteria,2M8K4@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
CMS3_k127_973387_0	706587.Desti_1849	3.964e-122	421.0	COG0726@1|root,COG0726@2|Bacteria,1QZSR@1224|Proteobacteria,43D4Q@68525|delta/epsilon subdivisions	1224|Proteobacteria	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,Polysacc_deac_1
CMS3_k127_973387_1	700598.Niako_1654	4.67e-07	63.0	COG5492@1|root,COG5492@2|Bacteria,4NT99@976|Bacteroidetes	976|Bacteroidetes	N	PFAM Bacterial Ig-like domain (group 2)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,CBM9_1,DM13,DUF4979,Pectate_lyase_3
CMS3_k127_973387_2	1168059.KB899087_gene1061	0.0003641	43.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3F0VP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
CMS3_k127_974919_0	1177179.A11A3_15906	1.504e-72	266.0	COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,1RR50@1236|Gammaproteobacteria,1XNMY@135619|Oceanospirillales	135619|Oceanospirillales	S	protease with the C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
CMS3_k127_974919_1	194439.CT0658	1.242e-57	222.0	COG5002@1|root,COG5002@2|Bacteria,1FETT@1090|Chlorobi	1090|Chlorobi	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02484,ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS
CMS3_k127_979326_1	1437448.AZRT01000016_gene1657	1.546e-06	62.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,1J3GX@118882|Brucellaceae	28211|Alphaproteobacteria	S	Alpha-2-Macroglobulin	MA20_30110	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,PAN_1,Thiol-ester_cl
CMS3_k127_979326_0	290397.Adeh_2037	8.559e-36	158.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,42MJ8@68525|delta/epsilon subdivisions,2WIVP@28221|Deltaproteobacteria,2YUDK@29|Myxococcales	28221|Deltaproteobacteria	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl
CMS3_k127_981175_2	344747.PM8797T_09799	2.632e-86	292.0	COG0222@1|root,COG0222@2|Bacteria,2IZS6@203682|Planctomycetes	203682|Planctomycetes	J	ribosome binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_981175_1	313628.LNTAR_09264	2.294e-140	465.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_981175_3	313628.LNTAR_17528	1.545e-19	90.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL,Lipase_GDSL_2
CMS3_k127_981175_0	1033732.CAHI01000006_gene2101	4.087e-179	575.0	COG3119@1|root,COG3119@2|Bacteria,4NEBN@976|Bacteroidetes,2FM3X@200643|Bacteroidia	976|Bacteroidetes	P	COG COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_981175_4	621372.ACIH01000020_gene1258	6.101e-15	86.0	COG3064@1|root,COG3064@2|Bacteria,1VB1V@1239|Firmicutes,4HJWH@91061|Bacilli,26UKZ@186822|Paenibacillaceae	91061|Bacilli	M	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_982520_0	63737.Npun_R6612	2.84e-61	237.0	COG1672@1|root,COG2319@1|root,COG3064@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,COG3064@2|Bacteria,1FZVW@1117|Cyanobacteria,1HMFW@1161|Nostocales	1117|Cyanobacteria	M	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35,WD40
CMS3_k127_991592_2	1353529.M899_2291	2.122e-41	173.0	COG2866@1|root,COG2866@2|Bacteria,1MZYN@1224|Proteobacteria,42PTT@68525|delta/epsilon subdivisions,2MT5U@213481|Bdellovibrionales,2WS13@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Zn_pept	-	-	3.4.17.18	ko:K05996	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M14
CMS3_k127_991592_0	365046.Rta_27840	5.372e-66	245.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2VHTQ@28216|Betaproteobacteria,4A9MB@80864|Comamonadaceae	28216|Betaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
CMS3_k127_991592_1	748449.Halha_1518	1.073e-43	168.0	COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia,3WAAI@53433|Halanaerobiales	186801|Clostridia	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
CMS3_k127_993965_4	1121935.AQXX01000120_gene4879	1.381e-07	63.0	2EGQV@1|root,33AH0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_993965_2	7668.SPU_021014-tr	4.608e-21	104.0	COG0666@1|root,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3BGGV@33208|Metazoa,3CT1S@33213|Bilateria	33208|Metazoa	M	ankyrin 3, node of Ranvier (ankyrin G)	ANK2	GO:0000278,GO:0000281,GO:0000323,GO:0000902,GO:0000904,GO:0000910,GO:0001508,GO:0002027,GO:0002028,GO:0003008,GO:0003012,GO:0003013,GO:0003015,GO:0003205,GO:0003230,GO:0003254,GO:0003279,GO:0003283,GO:0003674,GO:0005198,GO:0005200,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005773,GO:0005783,GO:0005794,GO:0005829,GO:0005856,GO:0005886,GO:0005887,GO:0005911,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0006873,GO:0006874,GO:0006875,GO:0006888,GO:0006892,GO:0006893,GO:0006928,GO:0006935,GO:0006936,GO:0006937,GO:0006941,GO:0006942,GO:0006996,GO:0007009,GO:0007010,GO:0007016,GO:0007049,GO:0007154,GO:0007165,GO:0007267,GO:0007275,GO:0007399,GO:0007409,GO:0007411,GO:0007507,GO:0007528,GO:0008015,GO:0008016,GO:0008092,GO:0008104,GO:0008150,GO:0009605,GO:0009653,GO:0009893,GO:0009986,GO:0009987,GO:0010035,GO:0010038,GO:0010171,GO:0010256,GO:0010468,GO:0010522,GO:0010604,GO:0010628,GO:0010646,GO:0010647,GO:0010649,GO:0010650,GO:0010765,GO:0010880,GO:0010881,GO:0010882,GO:0010959,GO:0010960,GO:0012505,GO:0014069,GO:0014704,GO:0014731,GO:0015031,GO:0015459,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0016192,GO:0016247,GO:0016323,GO:0016328,GO:0016528,GO:0016529,GO:0019222,GO:0019226,GO:0019228,GO:0019722,GO:0019725,GO:0019899,GO:0019900,GO:0019901,GO:0019932,GO:0022008,GO:0022402,GO:0022407,GO:0022409,GO:0022607,GO:0022898,GO:0023051,GO:0023052,GO:0030001,GO:0030003,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030030,GO:0030048,GO:0030054,GO:0030154,GO:0030155,GO:0030182,GO:0030315,GO:0030424,GO:0030425,GO:0030507,GO:0030674,GO:0031175,GO:0031224,GO:0031226,GO:0031430,GO:0031594,GO:0031647,GO:0031672,GO:0031674,GO:0032026,GO:0032279,GO:0032386,GO:0032388,GO:0032409,GO:0032410,GO:0032411,GO:0032412,GO:0032413,GO:0032414,GO:0032501,GO:0032502,GO:0032507,GO:0032879,GO:0032880,GO:0032970,GO:0032989,GO:0032990,GO:0033036,GO:0033157,GO:0033267,GO:0033268,GO:0033270,GO:0033292,GO:0033365,GO:0033563,GO:0034110,GO:0034112,GO:0034394,GO:0034613,GO:0034762,GO:0034763,GO:0034764,GO:0034765,GO:0034766,GO:0034767,GO:0035556,GO:0035637,GO:0036309,GO:0036371,GO:0036477,GO:0040008,GO:0040011,GO:0040014,GO:0040018,GO:0042221,GO:0042330,GO:0042383,GO:0042391,GO:0042592,GO:0042692,GO:0042886,GO:0042995,GO:0043001,GO:0043005,GO:0043034,GO:0043194,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043266,GO:0043267,GO:0043268,GO:0043269,GO:0043270,GO:0043271,GO:0043292,GO:0044057,GO:0044085,GO:0044091,GO:0044092,GO:0044093,GO:0044291,GO:0044304,GO:0044325,GO:0044422,GO:0044424,GO:0044425,GO:0044444,GO:0044449,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0045184,GO:0045185,GO:0045202,GO:0045211,GO:0045296,GO:0045760,GO:0045785,GO:0045838,GO:0045927,GO:0046907,GO:0048193,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048638,GO:0048639,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048878,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050808,GO:0050821,GO:0050839,GO:0050877,GO:0050896,GO:0051049,GO:0051050,GO:0051051,GO:0051094,GO:0051117,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051235,GO:0051239,GO:0051240,GO:0051270,GO:0051279,GO:0051282,GO:0051301,GO:0051641,GO:0051649,GO:0051651,GO:0051716,GO:0051899,GO:0051924,GO:0051928,GO:0055001,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055117,GO:0060047,GO:0060048,GO:0060090,GO:0060255,GO:0060306,GO:0060307,GO:0060341,GO:0061024,GO:0061061,GO:0061337,GO:0061564,GO:0061640,GO:0061951,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070252,GO:0070296,GO:0070727,GO:0070838,GO:0070887,GO:0070972,GO:0071241,GO:0071248,GO:0071286,GO:0071702,GO:0071705,GO:0071709,GO:0071840,GO:0071944,GO:0072359,GO:0072503,GO:0072507,GO:0072511,GO:0072657,GO:0072658,GO:0072659,GO:0072660,GO:0086001,GO:0086002,GO:0086003,GO:0086004,GO:0086005,GO:0086010,GO:0086012,GO:0086014,GO:0086015,GO:0086018,GO:0086019,GO:0086026,GO:0086036,GO:0086046,GO:0086065,GO:0086066,GO:0086070,GO:0086091,GO:0090087,GO:0090150,GO:0090257,GO:0090313,GO:0090314,GO:0090316,GO:0097060,GO:0097447,GO:0097458,GO:0097485,GO:0098590,GO:0098771,GO:0098772,GO:0098794,GO:0098876,GO:0098900,GO:0098901,GO:0098902,GO:0098904,GO:0098907,GO:0098910,GO:0098984,GO:0099080,GO:0099081,GO:0099106,GO:0099512,GO:0099572,GO:0099612,GO:0099623,GO:0120025,GO:0120036,GO:0120038,GO:0120039,GO:1900825,GO:1900827,GO:1901016,GO:1901017,GO:1901018,GO:1901019,GO:1901021,GO:1901379,GO:1901380,GO:1901381,GO:1902259,GO:1902260,GO:1902305,GO:1902307,GO:1903047,GO:1903115,GO:1903169,GO:1903522,GO:1903533,GO:1903779,GO:1903817,GO:1903827,GO:1903829,GO:1904062,GO:1904063,GO:1904064,GO:1904181,GO:1904427,GO:1904951,GO:1905475,GO:1905477,GO:1990778,GO:2000649,GO:2000651,GO:2001257,GO:2001258,GO:2001259	-	ko:K10380	ko04624,ko05205,map04624,map05205	-	-	-	ko00000,ko00001,ko04812	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5,Death,ZU5
CMS3_k127_993965_1	1173023.KE650771_gene3954	1.268e-145	474.0	COG0438@1|root,COG0438@2|Bacteria,1G1ED@1117|Cyanobacteria,1JHXV@1189|Stigonemataceae	1117|Cyanobacteria	M	Glycosyl transferases group 1	-	-	-	ko:K16703	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_993965_0	570952.ATVH01000003_gene696	5.733e-295	920.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TQJR@28211|Alphaproteobacteria,2JQA5@204441|Rhodospirillales	204441|Rhodospirillales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
CMS3_k127_994921_0	497964.CfE428DRAFT_0179	3.614e-15	83.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
CMS3_k127_994921_1	671143.DAMO_2029	0.0003061	48.0	COG5421@1|root,COG5421@2|Bacteria,2NQ27@2323|unclassified Bacteria	2|Bacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
CMS3_k127_996729_0	344747.PM8797T_09164	9.928e-34	132.0	COG3119@1|root,COG3119@2|Bacteria,2IXHT@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CMS3_k127_996729_2	1123392.AQWL01000009_gene1059	5.371e-08	64.0	COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2VHWW@28216|Betaproteobacteria	28216|Betaproteobacteria	C	eight transmembrane protein EpsH	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
CMS3_k127_996729_1	395019.Bmul_1064	3.323e-26	108.0	COG0667@1|root,COG0667@2|Bacteria,1MU1S@1224|Proteobacteria,2VMYU@28216|Betaproteobacteria,1K2AM@119060|Burkholderiaceae	28216|Betaproteobacteria	C	aldo keto reductase	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
CMS3_k127_9973_0	1128421.JAGA01000002_gene782	1.182e-107	361.0	COG0404@1|root,COG0404@2|Bacteria,2NNSR@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
CMS3_k127_9973_2	926690.KE386573_gene1022	4.072e-38	146.0	COG0509@1|root,arCOG01303@2157|Archaea,2XY1B@28890|Euryarchaeota,23W1R@183963|Halobacteria	183963|Halobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
CMS3_k127_9973_3	1123242.JH636438_gene5865	7.799e-30	131.0	COG0095@1|root,COG0095@2|Bacteria,2IZMX@203682|Planctomycetes	203682|Planctomycetes	H	PFAM Biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
CMS3_k127_9973_4	321327.CYA_0304	2.444e-06	58.0	COG3391@1|root,COG3391@2|Bacteria,1GJPK@1117|Cyanobacteria,1H2P6@1129|Synechococcus	1117|Cyanobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
CMS3_k127_9973_1	1280390.CBQR020000102_gene2505	1.591e-100	347.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,4HBV3@91061|Bacilli,26RWE@186822|Paenibacillaceae	91061|Bacilli	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
## 4614 queries scanned
## Total time (seconds): 245.7722511291504
## Rate: 18.77 q/s