## Sun Nov 10 12:18:37 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bins_4635/CMS3_bin.41.fa -m mmseqs --itype genome -o CMS3_bin.41 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/CMS3_bin.41 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
CMS3_k127_1013944_0	926564.KI911665_gene627	1.355e-276	902.0	COG1404@1|root,COG3979@1|root,COG1404@2|Bacteria,COG3979@2|Bacteria,2GK3D@201174|Actinobacteria,4F5NW@85017|Promicromonosporaceae	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,PA,Peptidase_S8
CMS3_k127_1013944_12	1125863.JAFN01000001_gene1814	1.909e-49	190.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,42VQA@68525|delta/epsilon subdivisions,2WUV1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
CMS3_k127_1013944_2	1313172.YM304_35550	5.131e-139	458.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4CMT6@84992|Acidimicrobiia	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN2	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
CMS3_k127_1013944_1	1122611.KB904001_gene8116	3.424e-141	465.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4EI1F@85012|Streptosporangiales	201174|Actinobacteria	C	Proton-conducting membrane transporter	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
CMS3_k127_1013944_4	1295642.H839_17373	1.072e-133	451.0	COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,4H9YR@91061|Bacilli,1WF39@129337|Geobacillus	91061|Bacilli	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
CMS3_k127_1013944_14	1157637.KB892096_gene1000	1.979e-26	111.0	COG0713@1|root,COG0713@2|Bacteria,2IHNW@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK2	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
CMS3_k127_1013944_15	561175.KB894093_gene4405	7.949e-26	116.0	COG0839@1|root,COG0839@2|Bacteria,2GJB7@201174|Actinobacteria,4EIJM@85012|Streptosporangiales	201174|Actinobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	nuoJ2	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
CMS3_k127_1013944_10	1229780.BN381_160029	1.69e-59	217.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
CMS3_k127_1013944_7	1229780.BN381_160027	1.107e-89	308.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,3UW85@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
CMS3_k127_1013944_3	1229780.BN381_160026	2.159e-135	443.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,3UWKD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Belongs to the complex I 49 kDa subunit family	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
CMS3_k127_1013944_13	1313172.YM304_35630	5.765e-29	124.0	COG0852@1|root,COG0852@2|Bacteria,2GNVP@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoC2	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
CMS3_k127_1013944_9	1229780.BN381_160024	5.164e-77	264.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,3UWJQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
CMS3_k127_1013944_16	4565.Traes_1BL_B410D05BB.1	5.115e-14	79.0	COG0838@1|root,KOG4662@2759|Eukaryota,37UN0@33090|Viridiplantae,3GISB@35493|Streptophyta,3M6IU@4447|Liliopsida,3II7V@38820|Poales	35493|Streptophyta	C	NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient	ndhC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008137,GO:0008150,GO:0008152,GO:0009507,GO:0009536,GO:0009987,GO:0015979,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K05574	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_q4
CMS3_k127_1013944_6	266117.Rxyl_1175	2.575e-97	331.0	COG1840@1|root,COG1840@2|Bacteria,2HRRI@201174|Actinobacteria,4CTU6@84995|Rubrobacteria	84995|Rubrobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
CMS3_k127_1013944_5	42256.RradSPS_1164	4.372e-126	422.0	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
CMS3_k127_1013944_8	316274.Haur_1720	2.065e-81	302.0	COG3842@1|root,COG3842@2|Bacteria,2G5P8@200795|Chloroflexi,37556@32061|Chloroflexia	32061|Chloroflexia	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
CMS3_k127_1013944_11	313606.M23134_05414	3.757e-50	187.0	COG0204@1|root,COG0204@2|Bacteria,4NHC8@976|Bacteroidetes,47JIM@768503|Cytophagia	976|Bacteroidetes	I	PFAM Phospholipid glycerol acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS3_k127_1025523_0	1229780.BN381_140043	9.565e-59	213.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
CMS3_k127_1025523_2	471852.Tcur_3050	6.888e-50	191.0	COG2129@1|root,COG2129@2|Bacteria,2GMTQ@201174|Actinobacteria,4EHDC@85012|Streptosporangiales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
CMS3_k127_1025523_3	1033730.CAHG01000016_gene413	1.656e-21	105.0	COG2867@1|root,COG2867@2|Bacteria,2IFH4@201174|Actinobacteria,4DRBM@85009|Propionibacteriales	201174|Actinobacteria	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2
CMS3_k127_1025523_1	102129.Lepto7375DRAFT_8371	1.038e-51	186.0	COG0003@1|root,COG0003@2|Bacteria,1G1UB@1117|Cyanobacteria,1H74M@1150|Oscillatoriales	1117|Cyanobacteria	P	TIGRFAM arsenite-activated ATPase ArsA	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
CMS3_k127_1042625_2	926569.ANT_01260	5.2e-119	391.0	COG0549@1|root,COG0549@2|Bacteria,2G6C7@200795|Chloroflexi	200795|Chloroflexi	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
CMS3_k127_1042625_1	196162.Noca_1631	2.115e-126	411.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4DV65@85009|Propionibacteriales	201174|Actinobacteria	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS3_k127_1042625_3	1423321.AS29_17980	4.827e-28	123.0	COG2188@1|root,COG2188@2|Bacteria,1TQQQ@1239|Firmicutes,4H9TG@91061|Bacilli,1ZB5M@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	ymfC	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
CMS3_k127_1042625_0	926550.CLDAP_10970	1.784e-142	458.0	COG0078@1|root,COG0078@2|Bacteria,2G7QE@200795|Chloroflexi	200795|Chloroflexi	E	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	-	-	2.1.3.9	ko:K09065	ko00220,ko01100,ko01230,map00220,map01100,map01230	M00845	R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS3_k127_1068301_3	543632.JOJL01000050_gene7447	2.113e-54	203.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4DH9I@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
CMS3_k127_1068301_6	1298863.AUEP01000022_gene1862	6.365e-35	136.0	COG2114@1|root,COG2114@2|Bacteria,2IQEQ@201174|Actinobacteria,4DV53@85009|Propionibacteriales	201174|Actinobacteria	T	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
CMS3_k127_1068301_0	204536.SULAZ_1552	2.637e-153	494.0	COG0499@1|root,COG0499@2|Bacteria,2G3TI@200783|Aquificae	200783|Aquificae	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
CMS3_k127_1068301_11	1538295.JY96_00840	1.489e-06	54.0	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2VW58@28216|Betaproteobacteria,1KMR9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the UPF0434 family	ycaR	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
CMS3_k127_1068301_1	928724.SacglDRAFT_03476	2.413e-137	451.0	COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,4DXQW@85010|Pseudonocardiales	201174|Actinobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	manB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS3_k127_1068301_5	391625.PPSIR1_32158	6.272e-50	186.0	COG0463@1|root,COG0463@2|Bacteria,1NKDW@1224|Proteobacteria,42XGP@68525|delta/epsilon subdivisions,2WTBI@28221|Deltaproteobacteria,2YUTR@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_1068301_10	263358.VAB18032_08955	3.066e-08	63.0	COG2246@1|root,COG2246@2|Bacteria,2IFFV@201174|Actinobacteria,4DDKD@85008|Micromonosporales	201174|Actinobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
CMS3_k127_1068301_2	1229780.BN381_10199	1.536e-109	382.0	COG5617@1|root,COG5617@2|Bacteria,2H32H@201174|Actinobacteria	201174|Actinobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1068301_8	1306174.JODP01000001_gene4642	7.651e-12	68.0	2DEEF@1|root,2ZMMR@2|Bacteria,2H9SH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1068301_9	56110.Oscil6304_0426	2.129e-11	67.0	2EV68@1|root,33NM1@2|Bacteria,1GFZ0@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1068301_12	1121035.AUCH01000013_gene3174	3.329e-05	51.0	COG0695@1|root,COG0695@2|Bacteria,1NFYH@1224|Proteobacteria,2VWFI@28216|Betaproteobacteria,2KXFR@206389|Rhodocyclales	206389|Rhodocyclales	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
CMS3_k127_1068301_7	1440053.JOEI01000007_gene2263	7.129e-27	129.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
CMS3_k127_1068301_4	1713.JOFV01000001_gene1928	5.305e-50	184.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4F18R@85016|Cellulomonadaceae	201174|Actinobacteria	S	Uncharacterised protein family UPF0052	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
CMS3_k127_1078278_3	1048339.KB913029_gene4617	1.38e-11	67.0	2EGHN@1|root,33A9R@2|Bacteria,2GSZ1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1078278_0	926550.CLDAP_06280	3.676e-124	406.0	COG2141@1|root,COG3255@1|root,COG2141@2|Bacteria,COG3255@2|Bacteria,2G878@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_1078278_2	134676.ACPL_4347	1.592e-22	102.0	COG0346@1|root,COG0346@2|Bacteria,2ISPK@201174|Actinobacteria,4DJQG@85008|Micromonosporales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_1078278_1	68260.JOAY01000002_gene5310	6.421e-85	287.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria	201174|Actinobacteria	E	Acetolactate synthase	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_1085506_2	887062.HGR_01071	2.183e-06	55.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,4A9XE@80864|Comamonadaceae	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
CMS3_k127_1085506_0	1283299.AUKG01000001_gene3595	9.845e-65	236.0	COG2114@1|root,COG2114@2|Bacteria,2H47X@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
CMS3_k127_1085506_1	298654.FraEuI1c_4720	4.458e-10	63.0	2EJAX@1|root,33D21@2|Bacteria,2GS9G@201174|Actinobacteria,4EX17@85013|Frankiales	201174|Actinobacteria	S	MT0933-like antitoxin protein	-	-	-	-	-	-	-	-	-	-	-	-	MT0933_antitox
CMS3_k127_1155304_0	1313172.YM304_02880	7.149e-146	477.0	COG0477@1|root,COG2814@2|Bacteria,2GKHG@201174|Actinobacteria,4CNYN@84992|Acidimicrobiia	84992|Acidimicrobiia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_1155304_2	987059.RBXJA2T_10069	7.424e-78	273.0	COG4335@1|root,COG4335@2|Bacteria,1P0C1@1224|Proteobacteria,2VISN@28216|Betaproteobacteria,1KIUS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA alkylation repair	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation,HEAT
CMS3_k127_1155304_4	929562.Emtol_0366	1.359e-08	68.0	COG2010@1|root,COG2010@2|Bacteria,4NFMJ@976|Bacteroidetes,47PY8@768503|Cytophagia	976|Bacteroidetes	C	TIGRFAM cytochrome c oxidase, cbb3-type, subunit III	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
CMS3_k127_1155304_6	1384056.N787_10295	8.111e-06	59.0	COG0607@1|root,COG2010@1|root,COG0607@2|Bacteria,COG2010@2|Bacteria,1R6Z0@1224|Proteobacteria,1RXZ9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,Rhodanese
CMS3_k127_1155304_3	670487.Ocepr_0101	9.758e-12	78.0	COG2010@1|root,COG2010@2|Bacteria,1WIF2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
CMS3_k127_1155304_5	575540.Isop_0042	4.472e-07	64.0	COG2319@1|root,COG2319@2|Bacteria,2IY5Q@203682|Planctomycetes	203682|Planctomycetes	M	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,PSCyt1,PSCyt2,PSD1,WD40
CMS3_k127_1155304_1	1379698.RBG1_1C00001G0857	2.227e-108	368.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	1379698.RBG1_1C00001G0857|-	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1194120_0	1499680.CCFE01000030_gene3448	2.44e-177	569.0	COG2936@1|root,COG2936@2|Bacteria,1TT0H@1239|Firmicutes,4HB0H@91061|Bacilli,1ZQDE@1386|Bacillus	91061|Bacilli	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	cocE	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS3_k127_1194120_7	56110.Oscil6304_1573	5.905e-113	381.0	COG2270@1|root,COG2270@2|Bacteria,1G3YB@1117|Cyanobacteria,1HA0N@1150|Oscillatoriales	1117|Cyanobacteria	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
CMS3_k127_1194120_8	326427.Cagg_2155	1.211e-103	351.0	COG2133@1|root,COG2133@2|Bacteria,2G62S@200795|Chloroflexi,375V8@32061|Chloroflexia	32061|Chloroflexia	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
CMS3_k127_1194120_4	1229780.BN381_430031	3.307e-129	424.0	COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,3UWEC@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Aminotransferase class-III	bioA2	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
CMS3_k127_1194120_2	384765.SIAM614_18959	3.65e-157	505.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
CMS3_k127_1194120_1	1122138.AQUZ01000005_gene2699	1.364e-165	530.0	COG1960@1|root,COG1960@2|Bacteria,2GM3V@201174|Actinobacteria,4DPAH@85009|Propionibacteriales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_1194120_10	67257.JODR01000006_gene2639	7.316e-63	229.0	COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CMS3_k127_1194120_6	935840.JAEQ01000011_gene1814	8.78e-122	400.0	COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,2TSXQ@28211|Alphaproteobacteria,43I2S@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Inosine-uridine preferring nucleoside hydrolase	rihA	GO:0003674,GO:0003824,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008655,GO:0009056,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009164,GO:0009165,GO:0009435,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019357,GO:0019358,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0034356,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0043094,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0045437,GO:0046135,GO:0046483,GO:0046496,GO:0046497,GO:0046700,GO:0050263,GO:0051186,GO:0051188,GO:0055086,GO:0070635,GO:0070636,GO:0071704,GO:0072521,GO:0072523,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
CMS3_k127_1194120_14	479431.Namu_2383	2.247e-45	177.0	COG2380@1|root,COG2380@2|Bacteria,2I8F9@201174|Actinobacteria,4EUZQ@85013|Frankiales	201174|Actinobacteria	S	COGs COG2380 conserved	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1194120_3	471852.Tcur_1913	1.908e-146	486.0	COG0433@1|root,COG0433@2|Bacteria,2I0H5@201174|Actinobacteria,4EGUT@85012|Streptosporangiales	201174|Actinobacteria	S	COG0433 Predicted ATPase	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	-
CMS3_k127_1194120_11	502025.Hoch_6132	1.803e-60	223.0	COG0420@1|root,COG0420@2|Bacteria,1MVV6@1224|Proteobacteria,432D3@68525|delta/epsilon subdivisions,2WYCS@28221|Deltaproteobacteria,2Z1T2@29|Myxococcales	28221|Deltaproteobacteria	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	-	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	SbcD_C
CMS3_k127_1194120_12	502025.Hoch_6131	1.266e-59	236.0	COG0419@1|root,COG0419@2|Bacteria,1MVTQ@1224|Proteobacteria,42NVV@68525|delta/epsilon subdivisions,2WJIZ@28221|Deltaproteobacteria,2Z1VS@29|Myxococcales	28221|Deltaproteobacteria	L	P-loop containing region of AAA domain	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
CMS3_k127_1194120_5	1123023.JIAI01000015_gene3299	4.653e-129	422.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4DYUC@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM CoA-transferase family III	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
CMS3_k127_1194120_16	1158318.ATXC01000001_gene30	1.41e-31	140.0	COG0569@1|root,COG0589@1|root,COG0569@2|Bacteria,COG0589@2|Bacteria,2G490@200783|Aquificae	200783|Aquificae	P	TrkA-N domain	-	-	-	ko:K09944	-	-	-	-	ko00000	-	-	-	TrkA_C,TrkA_N
CMS3_k127_1194120_9	1121405.dsmv_0512	1.346e-65	239.0	COG0475@1|root,COG0475@2|Bacteria,1PK6V@1224|Proteobacteria,439WW@68525|delta/epsilon subdivisions,2X290@28221|Deltaproteobacteria,2MPC7@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
CMS3_k127_1194120_15	1094980.Mpsy_1210	1.271e-31	129.0	COG2426@1|root,arCOG01330@2157|Archaea,2XZ2Y@28890|Euryarchaeota,2NAQX@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
CMS3_k127_1194120_13	649638.Trad_1273	6.363e-47	173.0	COG1490@1|root,COG1490@2|Bacteria,1WJUX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
CMS3_k127_1195045_0	479435.Kfla_5910	4.228e-138	454.0	COG2141@1|root,COG4639@1|root,COG2141@2|Bacteria,COG4639@2|Bacteria,2GM7W@201174|Actinobacteria,4DPZ7@85009|Propionibacteriales	201174|Actinobacteria	C	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,Bac_luciferase
CMS3_k127_1195045_3	1121921.KB898706_gene3381	1.951e-24	116.0	COG3291@1|root,COG3325@1|root,COG3979@1|root,COG3291@2|Bacteria,COG3325@2|Bacteria,COG3979@2|Bacteria,1MWAR@1224|Proteobacteria,1RPNS@1236|Gammaproteobacteria,2PMUU@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	G	Glyco_18	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_5_12,Glyco_hydro_18,PKD,fn3
CMS3_k127_1195045_2	1380356.JNIK01000011_gene1782	2.684e-31	138.0	COG1595@1|root,COG1595@2|Bacteria,2GN5Y@201174|Actinobacteria,4ESZT@85013|Frankiales	201174|Actinobacteria	K	sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_1195045_1	402881.Plav_0474	2.281e-133	430.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,1JNH3@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_1200368_1	1206101.AZXC01000008_gene3207	5.292e-19	93.0	2DN4G@1|root,32VGH@2|Bacteria,2ISQR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1200368_0	1042375.AFPL01000023_gene1700	1.882e-210	661.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,465UR@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	aldh1	-	1.2.1.3,1.2.1.83	ko:K00128,ko:K19700	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00811	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R10105	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_1246381_48	1385515.N791_12160	1.11e-38	146.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1X32R@135614|Xanthomonadales	135614|Xanthomonadales	O	Part of SUF system involved in inserting iron-sulfur clusters into proteins	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
CMS3_k127_1246381_9	485913.Krac_8822	3.089e-144	473.0	COG0520@1|root,COG0520@2|Bacteria,2G5T3@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
CMS3_k127_1246381_7	388401.RB2150_06943	1.93e-151	499.0	COG0028@1|root,COG0028@2|Bacteria,1MWVW@1224|Proteobacteria,2TTH5@28211|Alphaproteobacteria,3ZH40@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	H	Belongs to the TPP enzyme family	ilvB_1	-	2.2.1.6,4.1.1.75	ko:K01652,ko:K12253	ko00290,ko00330,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00330,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R03178,R04672,R04673,R08648	RC00027,RC00106,RC00506,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_1246381_59	670307.HYPDE_28323	1.038e-06	58.0	COG1773@1|root,COG1773@2|Bacteria,1N813@1224|Proteobacteria,2U0HG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	[NiFe]-hydrogenase assembly, chaperone, HybE	hupJ	-	-	-	-	-	-	-	-	-	-	-	NiFe-hyd_HybE,Rubredoxin
CMS3_k127_1246381_18	1313172.YM304_07300	1.171e-100	342.0	COG0477@1|root,COG2814@2|Bacteria,2GJK6@201174|Actinobacteria	201174|Actinobacteria	EGP	Drug resistance transporter, bcr cfla subfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
CMS3_k127_1246381_55	446470.Snas_5544	5.348e-20	101.0	COG0662@1|root,COG4977@1|root,COG0662@2|Bacteria,COG4977@2|Bacteria,2GTZX@201174|Actinobacteria,4F07R@85014|Glycomycetales	201174|Actinobacteria	K	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1246381_17	1238182.C882_0099	4.506e-104	347.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2TQKN@28211|Alphaproteobacteria,2JPPQ@204441|Rhodospirillales	204441|Rhodospirillales	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
CMS3_k127_1246381_4	1089551.KE386572_gene2812	1.782e-175	563.0	COG0824@1|root,COG1250@1|root,COG0824@2|Bacteria,COG1250@2|Bacteria,1MV8M@1224|Proteobacteria,2TRAW@28211|Alphaproteobacteria,4BPFC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	lcdH	-	1.1.1.108	ko:K17735	-	-	-	-	ko00000,ko01000	-	-	-	3HCDH,3HCDH_N,4HBT_2
CMS3_k127_1246381_5	1089551.KE386572_gene2813	2.43e-169	543.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,4BRRP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	acdA	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_1246381_25	1320556.AVBP01000007_gene612	1.332e-85	291.0	COG2513@1|root,COG2513@2|Bacteria,1R3SD@1224|Proteobacteria,2TRRV@28211|Alphaproteobacteria,43HIB@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
CMS3_k127_1246381_11	1385518.N798_05500	6.995e-134	451.0	COG2304@1|root,COG2304@2|Bacteria,2IDJD@201174|Actinobacteria,4FJUD@85021|Intrasporangiaceae	201174|Actinobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
CMS3_k127_1246381_8	1380394.JADL01000004_gene6010	6.214e-151	501.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2JPT9@204441|Rhodospirillales	204441|Rhodospirillales	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
CMS3_k127_1246381_19	1089551.KE386572_gene2815	2.995e-95	318.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRIH@28211|Alphaproteobacteria,4BQEZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	caiD	-	4.2.1.149	ko:K08299	-	-	R10675	RC01095	ko00000,ko01000	-	-	-	ECH_1
CMS3_k127_1246381_46	1385514.N782_11645	2.192e-41	157.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,4HIJ0@91061|Bacilli,2YA90@289201|Pontibacillus	91061|Bacilli	C	Nitrogen-fixing protein NifU	nifU	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
CMS3_k127_1246381_45	1125863.JAFN01000001_gene122	4.736e-43	173.0	COG0477@1|root,COG2814@2|Bacteria,1R842@1224|Proteobacteria,42QBY@68525|delta/epsilon subdivisions,2WKB6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_1246381_3	1229780.BN381_40065	9.532e-192	610.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria,3UW7P@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
CMS3_k127_1246381_30	867903.ThesuDRAFT_00393	8.457e-76	261.0	COG0396@1|root,COG0396@2|Bacteria,1TQ98@1239|Firmicutes,2489I@186801|Clostridia,3WD1B@538999|Clostridiales incertae sedis	186801|Clostridia	O	ATPases associated with a variety of cellular activities	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
CMS3_k127_1246381_53	469371.Tbis_1970	3.992e-20	98.0	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4E5XA@85010|Pseudonocardiales	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	sufE	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
CMS3_k127_1246381_44	479434.Sthe_1524	1.069e-45	183.0	COG0719@1|root,COG0719@2|Bacteria,2G5S8@200795|Chloroflexi,27Y27@189775|Thermomicrobia	189775|Thermomicrobia	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
CMS3_k127_1246381_54	743721.Psesu_1105	5.277e-20	97.0	COG0739@1|root,COG0739@2|Bacteria,1RK0U@1224|Proteobacteria,1SA4E@1236|Gammaproteobacteria,1XC42@135614|Xanthomonadales	135614|Xanthomonadales	M	Peptidase family M23	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
CMS3_k127_1246381_23	1122939.ATUD01000011_gene2213	1.071e-87	299.0	COG1573@1|root,COG1573@2|Bacteria,2GK1I@201174|Actinobacteria,4CPSB@84995|Rubrobacteria	84995|Rubrobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS3_k127_1246381_36	479434.Sthe_0511	5.544e-68	254.0	COG1306@1|root,COG1306@2|Bacteria,2G81Y@200795|Chloroflexi,27XJ9@189775|Thermomicrobia	189775|Thermomicrobia	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF4015
CMS3_k127_1246381_28	1123023.JIAI01000002_gene5279	3.766e-78	273.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4DY5T@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigB	GO:0000988,GO:0000990,GO:0001666,GO:0002791,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009410,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0016020,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032879,GO:0032880,GO:0036293,GO:0040007,GO:0042221,GO:0043175,GO:0043254,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051173,GO:0051223,GO:0051252,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0070063,GO:0070201,GO:0070482,GO:0071944,GO:0080090,GO:0090087,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:1903530,GO:2000112,GO:2000142,GO:2001141	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS3_k127_1246381_10	1245475.ANAE01000082_gene1914	7.305e-141	461.0	COG1028@1|root,COG1211@1|root,COG1028@2|Bacteria,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,4EGCB@85012|Streptosporangiales	201174|Actinobacteria	IQ	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	ispD	-	1.1.1.405,2.7.7.40,2.7.7.60	ko:K00991,ko:K21681	ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130	M00096	R01525,R02921,R05633	RC00002,RC00089	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,adh_short
CMS3_k127_1246381_43	219305.MCAG_04663	3.291e-51	203.0	COG1887@1|root,COG1887@2|Bacteria,2H6EP@201174|Actinobacteria,4DBXE@85008|Micromonosporales	201174|Actinobacteria	M	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyphos_transf
CMS3_k127_1246381_39	1120950.KB892759_gene6268	6.717e-63	225.0	COG0558@1|root,COG0558@2|Bacteria,2GN3C@201174|Actinobacteria,4DV9H@85009|Propionibacteriales	201174|Actinobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
CMS3_k127_1246381_12	1038859.AXAU01000003_gene6186	2.284e-133	438.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2TS3W@28211|Alphaproteobacteria,3JTIG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
CMS3_k127_1246381_26	479432.Sros_8188	4.012e-82	278.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4ENSK@85012|Streptosporangiales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_1246381_35	1037409.BJ6T_61730	3.239e-68	250.0	COG0845@1|root,COG3409@1|root,COG0845@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	3.2.1.35	ko:K01197,ko:K02022	ko00531,ko01100,map00531,map01100	M00076,M00077	R07824,R07825,R10905	-	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042	-	-	-	Biotin_lipoyl_2,HlyD_3,PG_binding_1,YkuD
CMS3_k127_1246381_56	1194165.CAJF01000013_gene1287	1.682e-17	95.0	2DG3P@1|root,2ZUBI@2|Bacteria,2IJPQ@201174|Actinobacteria,4FNQ2@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1246381_22	1313172.YM304_27370	4.154e-90	303.0	COG1637@1|root,COG1637@2|Bacteria,2GIYB@201174|Actinobacteria	201174|Actinobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
CMS3_k127_1246381_61	1121861.KB899938_gene3983	3.169e-05	54.0	COG3473@1|root,COG3473@2|Bacteria,1Q31P@1224|Proteobacteria,2U921@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Maleate cis-trans isomerase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
CMS3_k127_1246381_49	1120948.KB903243_gene2708	1.676e-30	127.0	COG0288@1|root,COG0288@2|Bacteria,2II5B@201174|Actinobacteria,4EF2P@85010|Pseudonocardiales	201174|Actinobacteria	P	Carbonic anhydrase	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
CMS3_k127_1246381_2	525904.Tter_1698	2.497e-221	694.0	COG0719@1|root,COG0719@2|Bacteria,2NNKT@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufB	sufB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
CMS3_k127_1246381_33	1313172.YM304_29040	2.452e-73	258.0	COG0697@1|root,COG0697@2|Bacteria,2GK49@201174|Actinobacteria,4CNC2@84992|Acidimicrobiia	84992|Acidimicrobiia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_1246381_32	502025.Hoch_5169	8.504e-74	257.0	COG0258@1|root,COG0258@2|Bacteria,1QV40@1224|Proteobacteria,43BZM@68525|delta/epsilon subdivisions,2X7AE@28221|Deltaproteobacteria,2YUE3@29|Myxococcales	28221|Deltaproteobacteria	L	Helix-hairpin-helix class 2 (Pol1 family) motifs	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
CMS3_k127_1246381_0	105420.BBPO01000019_gene5493	0.0	1770.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,2NEJ8@228398|Streptacidiphilus	201174|Actinobacteria	E	GXGXG motif	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
CMS3_k127_1246381_37	696369.KI912183_gene2743	5.139e-67	232.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,260N1@186807|Peptococcaceae	186801|Clostridia	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
CMS3_k127_1246381_1	1440774.Y900_012440	1.182e-222	700.0	COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,232J4@1762|Mycobacteriaceae	201174|Actinobacteria	C	glutamate synthase	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3858c	Fer4_20,Pyr_redox_2
CMS3_k127_1246381_60	40571.JOEA01000026_gene6094	5.096e-06	55.0	COG0702@1|root,COG0702@2|Bacteria,2ICEY@201174|Actinobacteria	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
CMS3_k127_1246381_41	1463881.KL591006_gene2448	1.225e-59	222.0	COG4552@1|root,COG4552@2|Bacteria,2GNXZ@201174|Actinobacteria	201174|Actinobacteria	S	N-acetyltransferase	eis	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
CMS3_k127_1246381_15	479435.Kfla_3670	2.959e-114	373.0	COG2141@1|root,COG2141@2|Bacteria,2GPA5@201174|Actinobacteria,4DNM5@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_1246381_40	1075090.GOAMR_76_00560	6.526e-62	216.0	COG2402@1|root,COG2402@2|Bacteria,2IRQ5@201174|Actinobacteria,4GGRX@85026|Gordoniaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
CMS3_k127_1246381_29	28072.Nos7524_2690	7.307e-77	273.0	COG3467@1|root,COG3467@2|Bacteria,1G4RC@1117|Cyanobacteria,1HK26@1161|Nostocales	1117|Cyanobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
CMS3_k127_1246381_47	502025.Hoch_4164	1.57e-39	159.0	COG3021@1|root,COG3021@2|Bacteria,1MWFK@1224|Proteobacteria,42QIQ@68525|delta/epsilon subdivisions,2WM7F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS3_k127_1246381_14	936053.I1C6X6	3.971e-123	418.0	COG0339@1|root,KOG2089@2759|Eukaryota,38SFI@33154|Opisthokonta,3NX1E@4751|Fungi,1GS81@112252|Fungi incertae sedis	4751|Fungi	O	Peptidase family M3	PRD1	GO:0000322,GO:0000323,GO:0000324,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005773,GO:0005794,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0012505,GO:0016787,GO:0019538,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0034641,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043603,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070011,GO:0070013,GO:0071704,GO:0140096,GO:1901564	3.4.24.37	ko:K01405,ko:K13726	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
CMS3_k127_1246381_21	926569.ANT_11030	2.212e-92	338.0	COG1449@1|root,COG4945@1|root,COG1449@2|Bacteria,COG4945@2|Bacteria	2|Bacteria	G	C-terminal binding-module, SLH-like, of glucodextranase	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Glucodextran_C,Glyco_hydro_57
CMS3_k127_1246381_34	309801.trd_A0308	4.68e-72	259.0	COG0318@1|root,COG0318@2|Bacteria,2G7PF@200795|Chloroflexi,27XJD@189775|Thermomicrobia	189775|Thermomicrobia	IQ	Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily	menE	-	6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_1246381_6	439235.Dalk_1406	2.82e-159	511.0	COG0447@1|root,COG0447@2|Bacteria,1QTZ2@1224|Proteobacteria,42MZ7@68525|delta/epsilon subdivisions,2WKXM@28221|Deltaproteobacteria,2MJNC@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_1246381_38	1122939.ATUD01000004_gene3903	8.794e-64	231.0	COG1575@1|root,COG1575@2|Bacteria,2GJBS@201174|Actinobacteria,4CQ7T@84995|Rubrobacteria	84995|Rubrobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
CMS3_k127_1246381_20	479434.Sthe_3024	5.779e-95	332.0	COG1165@1|root,COG1165@2|Bacteria,2G6JR@200795|Chloroflexi,27XZC@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	-	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N
CMS3_k127_1246381_31	1457250.BBMO01000001_gene202	6.973e-74	266.0	COG1169@1|root,arCOG02015@2157|Archaea,2XUD1@28890|Euryarchaeota,23SRN@183963|Halobacteria	183963|Halobacteria	H	Isochorismate synthase	menF	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
CMS3_k127_1246381_51	4792.ETI35776	1.329e-28	126.0	2D6R8@1|root,2T2QX@2759|Eukaryota,3QA5W@4776|Peronosporales	4776|Peronosporales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
CMS3_k127_1246381_50	284031.JNXD01000003_gene3748	3.482e-30	128.0	COG0517@1|root,COG0517@2|Bacteria,2GKSH@201174|Actinobacteria	201174|Actinobacteria	C	Cbs domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
CMS3_k127_1246381_58	1122179.KB890438_gene1558	2.859e-09	67.0	28H9B@1|root,2Z7M3@2|Bacteria,4NGVQ@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3244
CMS3_k127_1246381_27	1122611.KB903948_gene6697	9.825e-79	281.0	COG5002@1|root,COG5002@2|Bacteria,2I3U8@201174|Actinobacteria,4ER3K@85012|Streptosporangiales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_1246381_24	1380347.JNII01000007_gene741	6.175e-87	293.0	COG0745@1|root,COG0745@2|Bacteria,2GMVN@201174|Actinobacteria,4ESE2@85013|Frankiales	201174|Actinobacteria	T	Two component transcriptional regulator, winged helix family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_1246381_13	479433.Caci_2271	3.18e-131	436.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	ybiT	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn,DLIC
CMS3_k127_1246381_16	710421.Mycch_1468	5.499e-114	383.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,2361K@1762|Mycobacteriaceae	201174|Actinobacteria	C	Catalyzes the reduction of the keto moiety of phthiodiolone dimycocerosates (DIM B) and glycosylated phenolphthiodiolone dimycocerosates to form the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycocerosates during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis	-	-	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
CMS3_k127_1246381_42	1122611.KB903952_gene5823	2.109e-52	194.0	COG0491@1|root,COG0491@2|Bacteria,2GMHY@201174|Actinobacteria,4EJGQ@85012|Streptosporangiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	blaB3	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_1246381_57	1298880.AUEV01000018_gene338	2.288e-15	78.0	COG5555@1|root,COG5555@2|Bacteria,2GKZ9@201174|Actinobacteria	201174|Actinobacteria	N	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,FG-GAP_2,VCBS
CMS3_k127_1281239_16	1304865.JAGF01000001_gene2920	5.925e-17	93.0	COG0842@1|root,COG0842@2|Bacteria,2IITR@201174|Actinobacteria	201174|Actinobacteria	V	Abc-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CMS3_k127_1281239_9	1304865.JAGF01000001_gene2920	2.881e-74	260.0	COG0842@1|root,COG0842@2|Bacteria,2IITR@201174|Actinobacteria	201174|Actinobacteria	V	Abc-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CMS3_k127_1281239_5	1304865.JAGF01000001_gene2921	3.814e-127	413.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4F0HN@85016|Cellulomonadaceae	201174|Actinobacteria	V	TIGRFAM daunorubicin resistance ABC transporter ATPase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC_tran
CMS3_k127_1281239_3	926550.CLDAP_10980	4.166e-206	650.0	COG3033@1|root,COG3033@2|Bacteria,2G7YV@200795|Chloroflexi	200795|Chloroflexi	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	tpl	-	4.1.99.1,4.1.99.2	ko:K01667,ko:K01668	ko00350,ko00380,map00350,map00380	-	R00673,R00728	RC00209,RC00355,RC00364	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
CMS3_k127_1281239_12	1385935.N836_17290	8.563e-52	189.0	COG0705@1|root,COG0705@2|Bacteria,1G5DT@1117|Cyanobacteria,1H961@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS3_k127_1281239_10	552811.Dehly_0442	1.398e-65	237.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2
CMS3_k127_1281239_11	928724.SacglDRAFT_02958	3.845e-54	201.0	COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria,4E3DR@85010|Pseudonocardiales	201174|Actinobacteria	CO	Thiol-disulfide isomerase-like thioredoxin	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
CMS3_k127_1281239_17	477641.MODMU_1601	1.751e-15	86.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	-	-	2.7.11.1	ko:K12132,ko:K20543	-	-	-	-	ko00000,ko01000,ko01001,ko02000	1.B.55.3	-	-	AAA_16,NfrA_C,Pkinase,TPR_10,TPR_12,TPR_14,TPR_16,TPR_19,TPR_8
CMS3_k127_1281239_15	477641.MODMU_1602	2.759e-20	95.0	COG3088@1|root,COG3088@2|Bacteria,2GTYU@201174|Actinobacteria	201174|Actinobacteria	P	subunit of a heme lyase	ccmH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
CMS3_k127_1281239_4	1146883.BLASA_1890	5.965e-193	623.0	COG1138@1|root,COG1138@2|Bacteria,2HZM9@201174|Actinobacteria	201174|Actinobacteria	O	Cytochrome c-type biogenesis protein CcmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
CMS3_k127_1281239_6	204669.Acid345_2712	1.937e-104	358.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria,2JJ6B@204432|Acidobacteriia	57723|Acidobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
CMS3_k127_1281239_18	1340493.JNIF01000004_gene290	1.448e-13	84.0	COG2010@1|root,COG4654@1|root,COG2010@2|Bacteria,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PSCyt1,PSCyt2,PSD1
CMS3_k127_1281239_8	926569.ANT_26970	1.165e-83	302.0	COG2010@1|root,COG2864@1|root,COG2010@2|Bacteria,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB,PSCyt1
CMS3_k127_1281239_7	926569.ANT_26980	2.274e-95	326.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552,Cytochrom_c3_2,Paired_CXXCH_1
CMS3_k127_1281239_2	1288963.ADIS_4595	1.076e-232	730.0	COG2223@1|root,COG2223@2|Bacteria,4NETE@976|Bacteroidetes,47MEV@768503|Cytophagia	976|Bacteroidetes	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_1281239_1	1049564.TevJSym_ag00810	3.003e-282	874.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RMUK@1236|Gammaproteobacteria,1J96M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	nitrate nitrite transporter	narK	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
CMS3_k127_1281239_14	1184607.AUCHE_08_02010	3.15e-31	128.0	COG1959@1|root,COG1959@2|Bacteria	2|Bacteria	K	2 iron, 2 sulfur cluster binding	-	-	-	ko:K13771	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	Rrf2
CMS3_k127_1281239_13	869210.Marky_1849	5.285e-41	168.0	COG2010@1|root,COG2010@2|Bacteria,1WJ3M@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
CMS3_k127_1281239_0	926560.KE387023_gene2297	0.0	1419.0	COG5013@1|root,COG5013@2|Bacteria,1WJC1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding
CMS3_k127_1283114_0	1173027.Mic7113_0014	2.426e-210	670.0	COG0531@1|root,COG0531@2|Bacteria,1G248@1117|Cyanobacteria,1H8SD@1150|Oscillatoriales	1117|Cyanobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,SLC12
CMS3_k127_1283114_1	1380356.JNIK01000011_gene1833	2.043e-72	253.0	COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4ERXM@85013|Frankiales	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	serB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	HAD
CMS3_k127_1283246_1	1136177.KCA1_1411	2.422e-39	152.0	COG0134@1|root,COG0134@2|Bacteria,1TR94@1239|Firmicutes,4HDZQ@91061|Bacilli,3F5AK@33958|Lactobacillaceae	91061|Bacilli	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
CMS3_k127_1283246_2	1121927.GOHSU_35_00440	4.98e-28	123.0	COG0135@1|root,COG0135@2|Bacteria,2IHPP@201174|Actinobacteria,4GDTC@85026|Gordoniaceae	201174|Actinobacteria	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
CMS3_k127_1283246_0	1303518.CCALI_02665	2.572e-114	376.0	COG0133@1|root,COG0133@2|Bacteria	2|Bacteria	E	tryptophan synthase activity	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_1318072_3	1313172.YM304_10240	2.882e-22	99.0	COG0520@1|root,COG0520@2|Bacteria,2GKAF@201174|Actinobacteria	201174|Actinobacteria	E	Cysteine desulfurase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_1318072_2	1120983.KB894570_gene1233	4.057e-31	130.0	COG2050@1|root,COG2050@2|Bacteria,1PP3V@1224|Proteobacteria,2UVNH@28211|Alphaproteobacteria,1JPJM@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS3_k127_1318072_1	471852.Tcur_1719	3.966e-64	230.0	COG4976@1|root,COG4976@2|Bacteria,2I41M@201174|Actinobacteria,4ER5H@85012|Streptosporangiales	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12
CMS3_k127_1318072_0	1380390.JIAT01000010_gene3567	0.0	1386.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4CPJ1@84995|Rubrobacteria	84995|Rubrobacteria	E	Bacterial NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
CMS3_k127_1318072_4	44060.JODL01000001_gene3211	5.929e-17	81.0	COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria	201174|Actinobacteria	T	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
CMS3_k127_1366793_1	696369.KI912183_gene1105	3.72e-38	146.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,261WF@186807|Peptococcaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS3_k127_1366793_3	357808.RoseRS_0322	1.587e-12	81.0	COG0318@1|root,COG0318@2|Bacteria,2GBKJ@200795|Chloroflexi,3781K@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1366793_7	1122933.JNIY01000003_gene783	0.0006817	46.0	COG0526@1|root,COG0526@2|Bacteria,2IR6C@201174|Actinobacteria	201174|Actinobacteria	CO	Redoxin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
CMS3_k127_1366793_0	1449126.JQKL01000014_gene2976	1.058e-86	298.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,267KV@186813|unclassified Clostridiales	186801|Clostridia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
CMS3_k127_1366793_2	649743.HMPREF0972_01707	3.183e-18	87.0	2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,4D68S@85005|Actinomycetales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whmD	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
CMS3_k127_1366793_6	710421.Mycch_4299	1.163e-07	63.0	COG2105@1|root,COG4195@1|root,COG2105@2|Bacteria,COG4195@2|Bacteria,2GU51@201174|Actinobacteria,235BA@1762|Mycobacteriaceae	201174|Actinobacteria	C	Replication protein	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2,GGACT,Gamma_PGA_hydro
CMS3_k127_1366793_4	466038.KI421440_gene1114	2.999e-10	63.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,4BPBS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CMS3_k127_1385105_7	1288963.ADIS_0451	1.052e-06	51.0	COG0569@1|root,COG0569@2|Bacteria,4NE31@976|Bacteroidetes,47NY5@768503|Cytophagia	976|Bacteroidetes	P	TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS3_k127_1385105_1	1121904.ARBP01000003_gene6423	3.211e-118	396.0	COG0168@1|root,COG0168@2|Bacteria,4NGMF@976|Bacteroidetes,47JH5@768503|Cytophagia	976|Bacteroidetes	P	Cation transport protein	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS3_k127_1385105_5	756067.MicvaDRAFT_2486	2.551e-16	89.0	2DBMC@1|root,2Z9YC@2|Bacteria,1G29C@1117|Cyanobacteria,1HCAX@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1385105_0	1313172.YM304_07450	2.408e-256	809.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
CMS3_k127_1385105_6	767817.Desgi_1897	1.431e-14	86.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24JDV@186801|Clostridia,261XP@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the phosphoglycerate mutase family	pspA	-	3.1.3.3,3.1.3.73	ko:K02226,ko:K22305	ko00260,ko00680,ko00860,ko01100,ko01120,ko01130,map00260,map00680,map00860,map01100,map01120,map01130	M00122	R00582,R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
CMS3_k127_1385105_4	479434.Sthe_1072	4.696e-24	115.0	COG0406@1|root,COG0406@2|Bacteria,2G726@200795|Chloroflexi,27Z7X@189775|Thermomicrobia	189775|Thermomicrobia	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
CMS3_k127_1385105_3	326424.FRAAL5099	4.318e-63	232.0	COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,4ERSX@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	pimB	GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_1385105_2	452652.KSE_35790	1.118e-96	323.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,2M0W3@2063|Kitasatospora	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
CMS3_k127_1416317_1	1396141.BATP01000059_gene2529	1.548e-65	237.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GntR,Peripla_BP_3
CMS3_k127_1416317_2	1198114.AciX9_2492	1.995e-18	101.0	COG4932@1|root,COG4932@2|Bacteria,3Y8E2@57723|Acidobacteria	57723|Acidobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_1416317_0	530564.Psta_2519	4.861e-79	297.0	COG3345@1|root,COG3345@2|Bacteria,2J1YM@203682|Planctomycetes	203682|Planctomycetes	G	Pfam:DUF303	-	-	-	-	-	-	-	-	-	-	-	-	SASA
CMS3_k127_1455443_13	1267533.KB906734_gene3937	1.007e-26	117.0	COG1504@1|root,COG1504@2|Bacteria	2|Bacteria	L	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
CMS3_k127_1455443_5	1313172.YM304_38280	6.903e-71	246.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CNT1@84992|Acidimicrobiia	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_1455443_10	1313172.YM304_38290	1.462e-40	169.0	COG0577@1|root,COG0577@2|Bacteria,2GMC4@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type antimicrobial peptide transport system, permease component	hrtB	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_1455443_14	926550.CLDAP_20690	4.328e-20	102.0	COG0577@1|root,COG0577@2|Bacteria,2G6RX@200795|Chloroflexi	200795|Chloroflexi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
CMS3_k127_1455443_12	1313172.YM304_28070	8.377e-27	113.0	COG0251@1|root,COG0251@2|Bacteria,2IIB2@201174|Actinobacteria	201174|Actinobacteria	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
CMS3_k127_1455443_7	349521.HCH_00758	3.256e-59	215.0	COG4757@1|root,COG4757@2|Bacteria,1RI0P@1224|Proteobacteria,1SBZV@1236|Gammaproteobacteria,1XS5X@135619|Oceanospirillales	135619|Oceanospirillales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS3_k127_1455443_15	765420.OSCT_1662	5.347e-20	96.0	COG3502@1|root,COG3502@2|Bacteria,2G9SI@200795|Chloroflexi,3760N@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF952)	-	-	-	-	-	-	-	-	-	-	-	-	DUF952
CMS3_k127_1455443_9	1229780.BN381_350043	5.221e-46	173.0	COG4420@1|root,COG4420@2|Bacteria,2GQ5D@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
CMS3_k127_1455443_1	44060.JODL01000002_gene2376	2.117e-248	776.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,2GK6D@201174|Actinobacteria	201174|Actinobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fum	-	4.2.1.2,4.2.1.32	ko:K01676,ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
CMS3_k127_1455443_4	1197706.AKKK01000017_gene2658	1.359e-74	256.0	COG1309@1|root,COG1309@2|Bacteria,2GV75@201174|Actinobacteria,1WBEN@1268|Micrococcaceae	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
CMS3_k127_1455443_6	1304865.JAGF01000001_gene45	2.236e-64	231.0	arCOG07533@1|root,3167U@2|Bacteria,2INR8@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
CMS3_k127_1455443_0	1121405.dsmv_1320	0.0	1305.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS3_k127_1455443_2	1386089.N865_07750	5.95e-170	548.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4FEG7@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0016740,GO:0016765,GO:0016829,GO:0016846	-	ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01288	RC00020,RC02848	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0391	Cys_Met_Meta_PP
CMS3_k127_1455443_11	36809.MAB_4243c	3.511e-36	145.0	COG0607@1|root,COG0607@2|Bacteria,2IN3Q@201174|Actinobacteria,239DI@1762|Mycobacteriaceae	201174|Actinobacteria	P	sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CMS3_k127_1455443_16	1121020.JIAG01000013_gene1340	7.831e-11	69.0	COG5515@1|root,COG5515@2|Bacteria,2GUHP@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF1737)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1737
CMS3_k127_1455443_3	488538.SAR116_1436	7.264e-148	473.0	COG2084@1|root,COG2084@2|Bacteria,1PU4S@1224|Proteobacteria,2TT0X@28211|Alphaproteobacteria,4BPJG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
CMS3_k127_1455443_17	999541.bgla_1g28690	2.955e-09	68.0	COG0697@1|root,COG0697@2|Bacteria,1PX5W@1224|Proteobacteria,2VJ2A@28216|Betaproteobacteria,1K1ZI@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	Multidrug DMT transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_1455443_8	1313172.YM304_41740	1.323e-50	184.0	COG0477@1|root,COG2814@2|Bacteria,2I2DZ@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
CMS3_k127_1456080_1	1121918.ARWE01000001_gene3005	9.93e-120	392.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria,43U3A@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding
CMS3_k127_1456080_0	869210.Marky_1847	6.047e-260	813.0	COG1140@1|root,COG1140@2|Bacteria,1WI79@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	TIGRFAM nitrate reductase, beta subunit	-	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
CMS3_k127_1456080_3	670487.Ocepr_1423	1.03e-38	151.0	COG2180@1|root,COG2180@2|Bacteria,1WJDZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM Nitrate reductase delta subunit	-	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
CMS3_k127_1456080_2	869210.Marky_1845	1.054e-77	267.0	COG2181@1|root,COG2181@2|Bacteria,1WJFV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	TIGRFAM respiratory nitrate reductase, gamma subunit	-	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
CMS3_k127_1483561_3	292459.STH486	5.827e-107	364.0	COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia	186801|Clostridia	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
CMS3_k127_1483561_0	525904.Tter_0324	2.963e-188	599.0	COG0137@1|root,COG0137@2|Bacteria,2NP01@2323|unclassified Bacteria	2|Bacteria	E	Arginosuccinate synthase	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.argG,iSB619.SA_RS04675	Arginosuc_synth
CMS3_k127_1483561_9	1123258.AQXZ01000016_gene2243	2.168e-28	126.0	COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,4FW9V@85025|Nocardiaceae	201174|Actinobacteria	K	Regulates arginine biosynthesis genes	argR	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
CMS3_k127_1483561_5	1303518.CCALI_02162	3.09e-85	302.0	COG0548@1|root,COG0548@2|Bacteria	2|Bacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10565,iJN678.argB,iLJ478.TM1784	AA_kinase
CMS3_k127_1483561_4	675635.Psed_3835	3.511e-88	310.0	COG1364@1|root,COG1364@2|Bacteria,2GIW0@201174|Actinobacteria,4E0VH@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
CMS3_k127_1483561_6	1123267.JONN01000002_gene87	4.362e-85	293.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2TRMT@28211|Alphaproteobacteria,2K2G3@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh
CMS3_k127_1483561_2	1313172.YM304_25510	1.071e-145	471.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4CNFE@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_1483561_7	1349767.GJA_2335	6.78e-49	184.0	COG0500@1|root,COG2226@2|Bacteria,1PG9G@1224|Proteobacteria,2W935@28216|Betaproteobacteria,4785R@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_1483561_8	298655.KI912267_gene7126	7.239e-32	135.0	2BG6G@1|root,32A3A@2|Bacteria,2GPIW@201174|Actinobacteria	201174|Actinobacteria	S	Src homology 3 domains	-	-	-	-	-	-	-	-	-	-	-	-	SH3_2
CMS3_k127_1483561_1	1120950.KB892707_gene4568	6.314e-163	521.0	COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria,4DN07@85009|Propionibacteriales	201174|Actinobacteria	C	FMN-dependent dehydrogenase	lldD	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	1.1.2.3,1.1.3.15	ko:K00101,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00196,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	iNJ661.Rv1872c	FMN_dh
CMS3_k127_1483561_10	1032480.MLP_24830	1.798e-12	71.0	COG1595@1|root,COG1595@2|Bacteria,2HG34@201174|Actinobacteria,4DWA5@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1531913_6	411467.BACCAP_02528	2.47e-17	93.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,26886@186813|unclassified Clostridiales	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	yycG	-	2.7.13.3	ko:K07652	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_8,PAS_9
CMS3_k127_1531913_7	1349767.GJA_2449	5.914e-15	78.0	2EK70@1|root,33DXD@2|Bacteria,1NA99@1224|Proteobacteria,2WCK9@28216|Betaproteobacteria,477U2@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1531913_2	1206744.BAGL01000063_gene4683	1.39e-44	166.0	COG3871@1|root,COG3871@2|Bacteria,2I4HQ@201174|Actinobacteria,4G9UN@85025|Nocardiaceae	201174|Actinobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_1531913_5	796606.BMMGA3_07900	3.21e-19	93.0	COG2972@1|root,COG2972@2|Bacteria,1UAI6@1239|Firmicutes,4IKWP@91061|Bacilli,1ZI3J@1386|Bacillus	91061|Bacilli	T	2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	2TM
CMS3_k127_1531913_1	926550.CLDAP_18170	6.72e-118	396.0	COG1252@1|root,COG1252@2|Bacteria,2G5SS@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
CMS3_k127_1531913_0	1172188.KB911820_gene2447	2.767e-134	445.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4FFTR@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
CMS3_k127_1531913_3	33898.JRHJ01000008_gene4739	9.523e-37	148.0	COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria	201174|Actinobacteria	S	metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
CMS3_k127_1531913_4	1122611.KB903993_gene7357	3.239e-26	111.0	COG1643@1|root,COG1643@2|Bacteria,2GIWX@201174|Actinobacteria,4EGY7@85012|Streptosporangiales	201174|Actinobacteria	L	Helicase associated domain (HA2)  Add an annotation	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
CMS3_k127_1576461_2	479435.Kfla_0121	1.506e-30	140.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DSYF@85009|Propionibacteriales	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
CMS3_k127_1576461_3	42256.RradSPS_2650	6.125e-14	79.0	COG1225@1|root,COG1225@2|Bacteria	42256.RradSPS_2650|-	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1576461_1	1293054.HSACCH_00711	5.493e-37	153.0	2AVV0@1|root,31215@2|Bacteria,1V4K5@1239|Firmicutes,251D8@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF3159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3159
CMS3_k127_1576461_0	1122622.ATWJ01000014_gene448	4.993e-203	638.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4FG41@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
CMS3_k127_1576461_4	1229780.BN381_130173	1.086e-06	50.0	COG0694@1|root,COG0694@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	nfuA	-	-	ko:K07400	-	-	-	-	ko00000	-	-	-	Nfu_N,NifU
CMS3_k127_1599238_3	1313172.YM304_37890	7.08e-08	60.0	2AZ39@1|root,31R9K@2|Bacteria,2GMCY@201174|Actinobacteria	201174|Actinobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
CMS3_k127_1599238_0	1713.JOFV01000001_gene1954	2.12e-91	316.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria,4F32W@85016|Cellulomonadaceae	201174|Actinobacteria	G	Glycosyl transferases group 1	mshA	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_1599238_2	243164.DET1003	6.804e-20	104.0	COG5653@1|root,COG5653@2|Bacteria,2G6Z0@200795|Chloroflexi,34CZI@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
CMS3_k127_1599238_1	330084.JNYZ01000009_gene6480	5.03e-57	210.0	COG4448@1|root,COG4448@2|Bacteria,2GJA7@201174|Actinobacteria,4DYR1@85010|Pseudonocardiales	201174|Actinobacteria	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
CMS3_k127_1599238_4	1380393.JHVP01000002_gene1976	2.905e-06	53.0	2DP8R@1|root,32UKH@2|Bacteria,2IFBP@201174|Actinobacteria,4EWH3@85013|Frankiales	201174|Actinobacteria	-	-	amfC	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1604314_12	1123023.JIAI01000006_gene60	5.245e-13	71.0	COG1802@1|root,COG1802@2|Bacteria,2GKH7@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS3_k127_1604314_0	1187851.A33M_0952	2.256e-142	464.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like
CMS3_k127_1604314_9	266265.Bxe_A2429	1.608e-24	107.0	COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2VHTF@28216|Betaproteobacteria	28216|Betaproteobacteria	H	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
CMS3_k127_1604314_1	1048339.KB913029_gene3471	1.707e-119	401.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4ERZ8@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	iNJ661.Rv2992c	tRNA-synt_1c
CMS3_k127_1604314_4	926569.ANT_13710	1.132e-81	278.0	COG0179@1|root,COG0179@2|Bacteria,2G6H8@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
CMS3_k127_1604314_3	543913.D521_1813	1.856e-107	357.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,1KQJ3@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CMS3_k127_1604314_2	477641.MODMU_3652	9.073e-116	396.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GMMM@201174|Actinobacteria	201174|Actinobacteria	EU	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS3_k127_1604314_13	391165.GbCGDNIH1_1193	1.514e-11	76.0	COG1267@1|root,COG1267@2|Bacteria	2|Bacteria	I	phosphatidylglycerophosphatase activity	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
CMS3_k127_1604314_11	394221.Mmar10_0541	8.045e-14	84.0	COG2852@1|root,COG2852@2|Bacteria,1N0QU@1224|Proteobacteria,2UFZ7@28211|Alphaproteobacteria,4404S@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
CMS3_k127_1604314_7	643648.Slip_1758	1.021e-27	123.0	COG2998@1|root,COG2998@2|Bacteria,1TQA9@1239|Firmicutes,249EZ@186801|Clostridia,42JT0@68298|Syntrophomonadaceae	186801|Clostridia	H	ABC-type tungstate transport system permease component-like protein	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
CMS3_k127_1604314_8	1306174.JODP01000001_gene5144	1.102e-27	125.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
CMS3_k127_1604314_6	1382356.JQMP01000003_gene1638	8.701e-46	173.0	COG4662@1|root,COG4662@2|Bacteria,2G6ZF@200795|Chloroflexi,27Z7U@189775|Thermomicrobia	189775|Thermomicrobia	H	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
CMS3_k127_1604314_5	479432.Sros_9275	2.233e-52	201.0	COG1316@1|root,COG1316@2|Bacteria,2GM55@201174|Actinobacteria,4EHUC@85012|Streptosporangiales	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
CMS3_k127_1694177_0	1547437.LL06_20725	7.839e-148	477.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria,43IZR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS3_k127_1694177_3	314271.RB2654_20933	1.504e-100	343.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2TRXS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
CMS3_k127_1694177_1	314271.RB2654_20938	5.72e-131	431.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2TSTD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS3_k127_1694177_6	146922.JOFU01000031_gene5953	4.948e-06	57.0	2BZJQ@1|root,334P7@2|Bacteria,2I8YZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1694177_2	208439.AJAP_38870	7.244e-104	353.0	COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,4DZGZ@85010|Pseudonocardiales	201174|Actinobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
CMS3_k127_1694177_4	1957.JODX01000004_gene3335	7.044e-78	273.0	COG1623@1|root,COG1623@2|Bacteria,2GJ41@201174|Actinobacteria	201174|Actinobacteria	L	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process	disA	-	2.7.7.85	ko:K07067	-	-	-	-	ko00000,ko01000	-	-	-	DisA-linker,DisA_N,HHH,HHH_2
CMS3_k127_1694177_5	1121877.JQKF01000035_gene1966	8.51e-36	146.0	COG1329@1|root,COG1329@2|Bacteria,2GKSU@201174|Actinobacteria,4CN2D@84992|Acidimicrobiia	84992|Acidimicrobiia	K	CarD-like/TRCF domain	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
CMS3_k127_1703911_0	1057002.KB905370_gene3746	2.994e-152	490.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2TSZY@28211|Alphaproteobacteria,4BAUQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	gdh	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N,Response_reg
CMS3_k127_1703911_2	1193181.BN10_560065	1.283e-56	209.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,4FFDN@85021|Intrasporangiaceae	201174|Actinobacteria	L	Domain of unknown function DUF83	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
CMS3_k127_1703911_1	502025.Hoch_5157	9.871e-67	235.0	COG0515@1|root,COG0515@2|Bacteria,1R0MY@1224|Proteobacteria,43CYD@68525|delta/epsilon subdivisions,2X86J@28221|Deltaproteobacteria,2Z3M5@29|Myxococcales	502025.Hoch_5157|-	KLT	Domain of unknown function (DUF4032)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1718413_4	344747.PM8797T_30022	2.913e-49	184.0	COG1028@1|root,COG1028@2|Bacteria,2IXK3@203682|Planctomycetes	203682|Planctomycetes	IQ	Short-chain dehydrogenase reductase SDR	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
CMS3_k127_1718413_6	298655.KI912266_gene4398	4.2e-12	76.0	2ENVC@1|root,33GGF@2|Bacteria,2GYF8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1718413_5	926550.CLDAP_28290	1.337e-34	137.0	COG1539@1|root,COG1539@2|Bacteria	2|Bacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008719,GO:0009987,GO:0016853,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0071704,GO:1901360,GO:1901564	1.13.11.81,4.1.2.25,5.1.99.7,5.1.99.8	ko:K01633,ko:K07589	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073,R11082	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
CMS3_k127_1718413_2	1249627.D779_0391	2.182e-73	260.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1WWJK@135613|Chromatiales	135613|Chromatiales	H	PFAM GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
CMS3_k127_1718413_0	1382304.JNIL01000001_gene3015	1.043e-130	431.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,4HAKQ@91061|Bacilli,279ER@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
CMS3_k127_1718413_7	693661.Arcve_1726	1.145e-09	64.0	COG1765@1|root,arCOG03686@2157|Archaea	2157|Archaea	O	redox protein regulator of disulfide bond formation	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
CMS3_k127_1718413_1	1187851.A33M_1620	3.289e-81	280.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2U25R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
CMS3_k127_1718413_3	215803.DB30_2529	2.994e-61	216.0	COG0488@1|root,COG0488@2|Bacteria,1QUVR@1224|Proteobacteria,42P66@68525|delta/epsilon subdivisions,2WJ2D@28221|Deltaproteobacteria,2YWET@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS3_k127_173659_6	1121272.KB903250_gene3143	5.969e-20	91.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4D8PR@85008|Micromonosporales	201174|Actinobacteria	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	mshA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_173659_7	1313172.YM304_37890	4.074e-16	86.0	2AZ39@1|root,31R9K@2|Bacteria,2GMCY@201174|Actinobacteria	201174|Actinobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
CMS3_k127_173659_4	479434.Sthe_0963	6.917e-45	187.0	COG0577@1|root,COG0577@2|Bacteria,2G68F@200795|Chloroflexi,27Y16@189775|Thermomicrobia	189775|Thermomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_173659_1	324602.Caur_0822	5.156e-73	254.0	COG1136@1|root,COG1136@2|Bacteria,2G6C9@200795|Chloroflexi,37685@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,cNMP_binding
CMS3_k127_173659_2	2074.JNYD01000024_gene2861	5.724e-54	220.0	COG0745@1|root,COG3629@1|root,COG0745@2|Bacteria,COG3629@2|Bacteria,2GKKQ@201174|Actinobacteria,4E498@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
CMS3_k127_173659_0	1463921.JODF01000002_gene3096	5.27e-179	618.0	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria	201174|Actinobacteria	F	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,WD40
CMS3_k127_173659_5	386456.JQKN01000002_gene2431	1.3e-32	139.0	arCOG10857@1|root,arCOG10857@2157|Archaea,2Y4UI@28890|Euryarchaeota	28890|Euryarchaeota	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
CMS3_k127_173659_3	1499967.BAYZ01000040_gene2239	1.229e-46	187.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase,HemolysinCabind
CMS3_k127_1766912_10	471857.Svir_20980	2.282e-24	105.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4DXAY@85010|Pseudonocardiales	201174|Actinobacteria	J	Belongs to the amidase family	-	-	3.5.1.4,3.5.1.95	ko:K01426,ko:K19795	ko00240,ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00240,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590,R07629,R10778	RC00010,RC00090,RC00100,RC00141,RC00811,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
CMS3_k127_1766912_8	485913.Krac_11126	5.907e-31	128.0	COG0314@1|root,COG0314@2|Bacteria,2G6YQ@200795|Chloroflexi	200795|Chloroflexi	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	2.8.1.12	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
CMS3_k127_1766912_4	1211815.CBYP010000028_gene1049	6.524e-55	212.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4ESFY@85013|Frankiales	201174|Actinobacteria	O	peptidase S1 and S6, chymotrypsin Hap	degP	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_1766912_7	397278.JOJN01000006_gene968	3.7e-32	139.0	COG5282@1|root,COG5282@2|Bacteria,2GJ9K@201174|Actinobacteria,4DN9A@85009|Propionibacteriales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
CMS3_k127_1766912_6	1206726.BAFV01000022_gene1565	3.151e-40	154.0	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria,4FUKE@85025|Nocardiaceae	201174|Actinobacteria	O	Redoxin	ahpE	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
CMS3_k127_1766912_0	105425.BBPL01000065_gene5329	1.937e-163	523.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,2NETR@228398|Streptacidiphilus	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_1766912_9	706587.Desti_0651	6.224e-29	128.0	2EB22@1|root,3352W@2|Bacteria,1NE0W@1224|Proteobacteria,42VEE@68525|delta/epsilon subdivisions,2WRJF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1766912_3	391037.Sare_3188	4.863e-60	217.0	COG1309@1|root,COG1309@2|Bacteria,2HD07@201174|Actinobacteria,4DJYY@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_1766912_1	1043493.BBLU01000014_gene1312	1.436e-112	372.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS3_k127_1766912_2	1043493.BBLU01000014_gene1313	1.718e-98	342.0	COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria	201174|Actinobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
CMS3_k127_1766912_12	479435.Kfla_5479	2.508e-11	74.0	COG3026@1|root,COG3026@2|Bacteria,2IRR9@201174|Actinobacteria,4DSGE@85009|Propionibacteriales	201174|Actinobacteria	T	antisigma factor binding	-	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB
CMS3_k127_1766912_14	1121430.JMLG01000019_gene1643	0.0005216	51.0	COG5662@1|root,COG5662@2|Bacteria,1VKS6@1239|Firmicutes,24VD1@186801|Clostridia	186801|Clostridia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
CMS3_k127_1766912_5	749927.AMED_1067	2.574e-48	178.0	COG1595@1|root,COG1595@2|Bacteria,2GK4C@201174|Actinobacteria,4DYCJ@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigE	GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1766912_11	526227.Mesil_3475	7.388e-22	100.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
CMS3_k127_1784576_2	1229780.BN381_50177	8.518e-34	132.0	COG0133@1|root,COG0133@2|Bacteria,2GM7Z@201174|Actinobacteria,3UWAH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_1784576_1	1288079.AUKN01000003_gene3566	3.482e-53	199.0	COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria	201174|Actinobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
CMS3_k127_1784576_0	1223543.GP2_011_01110	2.283e-91	311.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4GA2Z@85026|Gordoniaceae	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
CMS3_k127_1814906_3	489825.LYNGBM3L_24250	1.281e-16	92.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,DUF4347,HemolysinCabind,PA14,PATR,Peptidase_M10_C
CMS3_k127_1814906_6	1123058.KB894226_gene41	0.0001124	46.0	COG0861@1|root,COG0861@2|Bacteria,4NFFD@976|Bacteroidetes,1HXRT@117743|Flavobacteriia	976|Bacteroidetes	P	membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
CMS3_k127_1814906_5	292414.TM1040_1263	2.848e-07	59.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2TR46@28211|Alphaproteobacteria,4NANN@97050|Ruegeria	28211|Alphaproteobacteria	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8
CMS3_k127_1814906_7	1239415.CM001837_gene2289	0.0005371	47.0	COG0642@1|root,COG0784@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5000@2|Bacteria,4NDXU@976|Bacteroidetes,1HZV8@117743|Flavobacteriia,37EY2@326319|Dokdonia	976|Bacteroidetes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
CMS3_k127_1814906_0	930166.CD58_17700	3.327e-123	420.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GAF_2,GGDEF,PAS,PAS_9
CMS3_k127_1814906_1	381666.H16_A1828	7.354e-97	343.0	COG2133@1|root,COG2133@2|Bacteria,1R86D@1224|Proteobacteria,2VXMI@28216|Betaproteobacteria,1K4V5@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
CMS3_k127_1814906_2	1254432.SCE1572_09945	2.682e-55	218.0	COG5555@1|root,COG5555@2|Bacteria,1QX82@1224|Proteobacteria,43CYG@68525|delta/epsilon subdivisions,2X86M@28221|Deltaproteobacteria,2Z3M6@29|Myxococcales	28221|Deltaproteobacteria	N	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP
CMS3_k127_1844653_3	251221.35213259	1.04e-84	308.0	COG0344@1|root,COG0574@1|root,COG3848@1|root,COG0344@2|Bacteria,COG0574@2|Bacteria,COG3848@2|Bacteria,1G2NJ@1117|Cyanobacteria	1117|Cyanobacteria	GT	Pyruvate phosphate dikinase, PEP pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	G3P_acyltransf,PEP-utilizers,PPDK_N
CMS3_k127_1844653_4	926569.ANT_26440	1.114e-29	127.0	COG0344@1|root,COG0344@2|Bacteria	2|Bacteria	I	acyl-phosphate glycerol-3-phosphate acyltransferase activity	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
CMS3_k127_1844653_1	1313172.YM304_36000	5.832e-128	418.0	COG3752@1|root,COG3752@2|Bacteria,2GNX1@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
CMS3_k127_1844653_2	543632.JOJL01000035_gene5071	1.382e-89	315.0	arCOG06481@1|root,2ZB4E@2|Bacteria,2I95D@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1844653_0	861299.J421_1936	2.979e-197	634.0	COG3158@1|root,COG3158@2|Bacteria,1ZTCK@142182|Gemmatimonadetes	2|Bacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
CMS3_k127_1853466_0	675635.Psed_1304	4.012e-201	648.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4DXGB@85010|Pseudonocardiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpV	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009405,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0042221,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0050896,GO:0051704,GO:0071944	3.6.3.4,3.6.3.54	ko:K01533,ko:K12954,ko:K12956,ko:K17686,ko:K21887	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3,3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
CMS3_k127_1853466_5	675635.Psed_1303	2.231e-11	71.0	COG2608@1|root,COG2608@2|Bacteria,2GXF6@201174|Actinobacteria,4EDAJ@85010|Pseudonocardiales	201174|Actinobacteria	P	Heavy-metal-associated domain	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
CMS3_k127_1853466_2	525368.HMPREF0591_0648	2.467e-28	116.0	COG1937@1|root,COG1937@2|Bacteria,2IKU8@201174|Actinobacteria,23AA3@1762|Mycobacteriaceae	201174|Actinobacteria	K	Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes. Binds to a GC-rich pseudopallindromic sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region	csoR	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010038,GO:0010272,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042221,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046688,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097077,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
CMS3_k127_1853466_1	1304865.JAGF01000001_gene77	6.983e-73	254.0	COG1595@1|root,COG1595@2|Bacteria,2GTCV@201174|Actinobacteria	201174|Actinobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2,zf-HC2
CMS3_k127_1853466_4	926569.ANT_03010	2.539e-12	78.0	COG3118@1|root,COG3118@2|Bacteria,2G70B@200795|Chloroflexi	200795|Chloroflexi	O	Protein of unknown function (DUF2892)	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	DUF2892,Thioredoxin
CMS3_k127_1853466_6	1382356.JQMP01000001_gene1284	1.723e-06	55.0	COG5349@1|root,COG5349@2|Bacteria,2G7FQ@200795|Chloroflexi,27ZAC@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
CMS3_k127_1853466_3	926550.CLDAP_39350	1.325e-19	90.0	2BH31@1|root,32B3S@2|Bacteria,2G9T0@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
CMS3_k127_1870951_2	1198452.Jab_2c07220	5.003e-77	274.0	COG0477@1|root,COG2814@2|Bacteria,1QUZN@1224|Proteobacteria,2W244@28216|Betaproteobacteria,475JJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_1870951_0	58123.JOFJ01000029_gene1113	7.096e-98	324.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_1870951_1	1211815.CBYP010000062_gene3184	3.349e-88	307.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,4EUN5@85013|Frankiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
CMS3_k127_1876971_1	2002.JOEQ01000001_gene4895	1.34e-172	548.0	COG0174@1|root,COG0174@2|Bacteria,2GKU9@201174|Actinobacteria,4EHB0@85012|Streptosporangiales	201174|Actinobacteria	E	Glutamine synthetase, beta-Grasp domain	glnII	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
CMS3_k127_1876971_2	880072.Desac_1040	6.666e-166	534.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2MR6S@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
CMS3_k127_1876971_5	1313172.YM304_38350	1.257e-50	190.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4CN27@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
CMS3_k127_1876971_6	1449353.JQMQ01000005_gene4807	2.601e-42	178.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria,2NFSB@228398|Streptacidiphilus	201174|Actinobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
CMS3_k127_1876971_4	1313172.YM304_27430	3.358e-51	198.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4CMZX@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
CMS3_k127_1876971_0	391625.PPSIR1_05678	1.798e-175	576.0	COG0160@1|root,COG2334@1|root,COG0160@2|Bacteria,COG2334@2|Bacteria,1MX0Y@1224|Proteobacteria	1224|Proteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	APH,Aminotran_3,Peptidase_M23
CMS3_k127_1876971_3	1380393.JHVP01000001_gene2429	3.841e-139	455.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4EV33@85013|Frankiales	201174|Actinobacteria	Q	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_1876971_8	431947.PGN_1097	6.921e-09	67.0	2CPS1@1|root,32SJR@2|Bacteria,4NTZ6@976|Bacteroidetes,2FPC8@200643|Bacteroidia,22YDC@171551|Porphyromonadaceae	976|Bacteroidetes	S	Protein of unknown function (DUF3298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3298,DUF4163
CMS3_k127_1876971_7	44060.JODL01000012_gene3617	3.705e-20	102.0	COG3206@1|root,COG3206@2|Bacteria,2GPMH@201174|Actinobacteria	201174|Actinobacteria	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
CMS3_k127_1898065_1	1869.MB27_11625	4.557e-27	118.0	COG1309@1|root,COG1309@2|Bacteria,2GZ1Y@201174|Actinobacteria,4DDXG@85008|Micromonosporales	201174|Actinobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
CMS3_k127_1898100_0	525904.Tter_1921	9.932e-38	152.0	COG5516@1|root,COG5516@2|Bacteria	2|Bacteria	S	CGNR zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
CMS3_k127_1898100_1	247490.KSU1_D0117	1.133e-20	95.0	COG4870@1|root,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	DUF900,Peptidase_C1
CMS3_k127_1913134_4	404589.Anae109_3641	2.087e-12	77.0	2E3NC@1|root,32YKG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1913134_5	1123508.JH636447_gene7962	3.01e-10	72.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,PSCyt1
CMS3_k127_1913134_2	1267535.KB906767_gene3015	2.691e-25	120.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,3Y4F0@57723|Acidobacteria,2JKSY@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C
CMS3_k127_1913134_1	706587.Desti_1891	2.65e-54	198.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WPA2@28221|Deltaproteobacteria,2MQIC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Cytochrome b/b6/petB	cbcW	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2,Cytochrom_C,Cytochrome_B,Cytochrome_CBB3
CMS3_k127_1913134_3	1123278.KB893387_gene4385	1.976e-19	95.0	COG0723@1|root,COG0723@2|Bacteria,4PNQJ@976|Bacteroidetes,47SP8@768503|Cytophagia	976|Bacteroidetes	C	Rieske [2Fe-2S] domain	-	-	-	ko:K03886	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
CMS3_k127_1913134_0	391625.PPSIR1_01367	2.875e-75	259.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42UHA@68525|delta/epsilon subdivisions,2WQA0@28221|Deltaproteobacteria,2YUHZ@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
CMS3_k127_1983908_5	101510.RHA1_ro00959	1.183e-08	63.0	COG0016@1|root,COG0016@2|Bacteria,2GJGG@201174|Actinobacteria,4FWBH@85025|Nocardiaceae	201174|Actinobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
CMS3_k127_1983908_4	309801.trd_0830	4.714e-29	127.0	COG0566@1|root,COG0566@2|Bacteria,2G6MC@200795|Chloroflexi,27YC9@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
CMS3_k127_1983908_2	65497.JODV01000003_gene4811	1.722e-43	161.0	COG0292@1|root,COG0292@2|Bacteria,2IHTN@201174|Actinobacteria,4E3EP@85010|Pseudonocardiales	201174|Actinobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
CMS3_k127_1983908_6	1292373.H640_08057	1.803e-08	58.0	COG0291@1|root,COG0291@2|Bacteria,2GQZW@201174|Actinobacteria,4DSHV@85009|Propionibacteriales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
CMS3_k127_1983908_1	351607.Acel_1269	7.735e-53	194.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4ESDW@85013|Frankiales	201174|Actinobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
CMS3_k127_1983908_3	1235279.C772_00367	2.539e-33	134.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,4HFRA@91061|Bacilli,26EVD@186818|Planococcaceae	91061|Bacilli	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08940	DMRL_synthase
CMS3_k127_1983908_0	585531.HMPREF0063_10624	1.9e-56	200.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GIWJ@201174|Actinobacteria,4DNA4@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
CMS3_k127_1984750_9	243160.BMA1902	0.0004807	51.0	COG0477@1|root,COG2814@2|Bacteria,1N8TD@1224|Proteobacteria,2WFIX@28216|Betaproteobacteria,1K3FJ@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_1984750_3	1121918.ARWE01000001_gene3039	1.74e-78	273.0	COG0668@1|root,COG0668@2|Bacteria,1PMY3@1224|Proteobacteria,42M4K@68525|delta/epsilon subdivisions,2WWCN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
CMS3_k127_1984750_4	298655.KI912266_gene4190	1.33e-64	231.0	COG1234@1|root,COG1234@2|Bacteria,2HV83@201174|Actinobacteria	201174|Actinobacteria	S	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
CMS3_k127_1984750_0	258594.RPA4672	7.275e-188	597.0	COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2TRFI@28211|Alphaproteobacteria,3JS7Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
CMS3_k127_1984750_7	446470.Snas_5196	8.194e-10	63.0	2B4QQ@1|root,31XH0@2|Bacteria,2HZ46@201174|Actinobacteria,4F08V@85014|Glycomycetales	201174|Actinobacteria	S	Domain of unknown function (DUF1876)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1876
CMS3_k127_1984750_5	1229780.BN381_100054	1.362e-60	220.0	COG5479@1|root,COG5479@2|Bacteria,2GMJR@201174|Actinobacteria	201174|Actinobacteria	M	Protein of unknown function (DUF3152)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3152
CMS3_k127_1984750_8	649831.L083_7115	3.632e-05	53.0	COG4319@1|root,COG4319@2|Bacteria,2IRHC@201174|Actinobacteria,4DFA7@85008|Micromonosporales	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
CMS3_k127_1984750_6	76636.JOEC01000002_gene2468	3.019e-20	98.0	COG2220@1|root,COG2220@2|Bacteria,2GNHK@201174|Actinobacteria,4FN27@85023|Microbacteriaceae	201174|Actinobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CMS3_k127_1984750_1	1313172.YM304_21860	6.201e-110	362.0	COG0300@1|root,COG0300@2|Bacteria,2GK2K@201174|Actinobacteria	201174|Actinobacteria	S	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_1984750_2	309807.SRU_1339	3.793e-88	304.0	COG1578@1|root,COG1578@2|Bacteria,4PEMD@976|Bacteroidetes,1FJAK@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Protein of unknown function DUF89	-	-	-	-	-	-	-	-	-	-	-	-	DUF89
CMS3_k127_1992247_3	1313172.YM304_30080	2.028e-50	189.0	COG1682@1|root,COG1682@2|Bacteria,2GP5K@201174|Actinobacteria	201174|Actinobacteria	GM	Transport permease protein	tagG	-	-	ko:K09692	ko02010,map02010	M00251	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.104	-	-	ABC2_membrane
CMS3_k127_1992247_13	641491.DND132_0187	6.442e-05	54.0	COG1874@1|root,COG1874@2|Bacteria,1PUBE@1224|Proteobacteria,436VJ@68525|delta/epsilon subdivisions,2WWCE@28221|Deltaproteobacteria,2MF74@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1992247_0	1122947.FR7_2330	1.145e-215	681.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H219@909932|Negativicutes	909932|Negativicutes	C	Aldehyde dehydrogenase family	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_1992247_1	1229780.BN381_310078	1.782e-108	363.0	COG1035@1|root,COG1146@1|root,COG1035@2|Bacteria,COG1146@2|Bacteria,2GRHK@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4_9,FrhB_FdhB_C,FrhB_FdhB_N
CMS3_k127_1992247_6	765420.OSCT_2237	4.108e-42	168.0	COG3153@1|root,COG3153@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_1992247_11	263358.VAB18032_16965	3.401e-07	60.0	29P1W@1|root,30A02@2|Bacteria,2IE5P@201174|Actinobacteria,4D9GV@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1992247_9	1411685.U062_00425	9.571e-19	94.0	COG1309@1|root,COG1309@2|Bacteria,1MUUY@1224|Proteobacteria,1S8AC@1236|Gammaproteobacteria,1J6K4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	COG1309 Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
CMS3_k127_1992247_4	1169152.AXVD01000023_gene3256	2.974e-48	192.0	COG2021@1|root,COG2021@2|Bacteria,2HIEG@201174|Actinobacteria,4G3VG@85025|Nocardiaceae	201174|Actinobacteria	E	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_1992247_7	1382356.JQMP01000003_gene2013	1.116e-24	113.0	COG2141@1|root,COG2141@2|Bacteria,2G8NG@200795|Chloroflexi,27Y54@189775|Thermomicrobia	189775|Thermomicrobia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_1992247_8	861299.J421_0232	8.062e-21	96.0	COG3055@1|root,COG3055@2|Bacteria,1ZUV8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4
CMS3_k127_1992247_12	1121377.KB906398_gene2319	4.861e-05	51.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,Kelch_4
CMS3_k127_1992247_2	1161401.ASJA01000004_gene2302	1.267e-94	350.0	COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,1RDZC@1224|Proteobacteria	1224|Proteobacteria	O	serine protease protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS3_k127_1992247_10	350054.Mflv_1982	2.29e-09	65.0	2BJ39@1|root,32DC5@2|Bacteria,2GU2X@201174|Actinobacteria,23B60@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1992247_5	1146883.BLASA_1794	1.525e-43	167.0	COG4974@1|root,COG4974@2|Bacteria,2HD2H@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
CMS3_k127_1998635_0	671143.DAMO_1946	7.687e-109	386.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PKD,SBBP
CMS3_k127_2003402_3	710696.Intca_3342	9.607e-31	136.0	2EZYF@1|root,33T2N@2|Bacteria,2H3P5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2003402_0	991905.SL003B_3075	5.171e-203	643.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,4BPJA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	matB	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_2003402_4	314278.NB231_08595	4.563e-18	88.0	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria,1WZC1@135613|Chromatiales	135613|Chromatiales	C	acylphosphatase	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
CMS3_k127_2003402_1	748247.AZKH_p0140	6.538e-163	530.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VI46@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
CMS3_k127_2003402_2	66429.JOFL01000007_gene2321	3.82e-131	430.0	COG1960@1|root,COG1960@2|Bacteria,2GK1M@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_200491_0	1313172.YM304_11100	9.248e-222	718.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4CMSA@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase family M1 domain	-	-	-	ko:K08776	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
CMS3_k127_200491_4	928724.SacglDRAFT_02958	1.14e-52	193.0	COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria,4E3DR@85010|Pseudonocardiales	201174|Actinobacteria	CO	Thiol-disulfide isomerase-like thioredoxin	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
CMS3_k127_200491_14	1146883.BLASA_3081	4.491e-16	91.0	COG0457@1|root,COG3088@1|root,COG0457@2|Bacteria,COG3088@2|Bacteria,2GXH0@201174|Actinobacteria	201174|Actinobacteria	O	subunit of a heme lyase	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
CMS3_k127_200491_1	1146883.BLASA_1890	1.206e-192	621.0	COG1138@1|root,COG1138@2|Bacteria,2HZM9@201174|Actinobacteria	201174|Actinobacteria	O	Cytochrome c-type biogenesis protein CcmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
CMS3_k127_200491_11	1146883.BLASA_1901	1.594e-24	108.0	COG2332@1|root,COG2332@2|Bacteria,2GZPB@201174|Actinobacteria	201174|Actinobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
CMS3_k127_200491_2	1089546.AQUI01000002_gene3234	1.681e-62	222.0	COG0755@1|root,COG0755@2|Bacteria,2IIHK@201174|Actinobacteria	201174|Actinobacteria	O	cytochrome C assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
CMS3_k127_200491_5	928724.SacglDRAFT_02964	8.052e-50	187.0	COG2386@1|root,COG2386@2|Bacteria,2HRH1@201174|Actinobacteria,4EAQG@85010|Pseudonocardiales	201174|Actinobacteria	O	CcmB protein	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
CMS3_k127_200491_3	1146883.BLASA_1905	4.962e-57	206.0	COG1131@1|root,COG1131@2|Bacteria,2IRXJ@201174|Actinobacteria	201174|Actinobacteria	V	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
CMS3_k127_200491_13	1463920.JOGB01000064_gene4352	1.075e-18	100.0	COG2931@1|root,COG3291@1|root,COG4409@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	ASH,Big_3_2,F5_F8_type_C,HemolysinCabind,SBBP
CMS3_k127_200491_12	1048983.EL17_05775	5.07e-21	108.0	COG3204@1|root,COG3204@2|Bacteria,4NNX0@976|Bacteroidetes,47P1B@768503|Cytophagia	976|Bacteroidetes	L	pilus organization	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_200491_6	1049564.TevJSym_bm00090	1.018e-45	169.0	COG3118@1|root,COG3118@2|Bacteria,1RHRZ@1224|Proteobacteria,1S7F0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS3_k127_200491_10	358220.C380_12605	1.104e-24	120.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGKF@28216|Betaproteobacteria,4AGRT@80864|Comamonadaceae	28216|Betaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
CMS3_k127_200491_9	335543.Sfum_0480	2.394e-38	151.0	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,42T3V@68525|delta/epsilon subdivisions,2X2EJ@28221|Deltaproteobacteria,2MSD1@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Nudix N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
CMS3_k127_200491_7	1380354.JIAN01000006_gene1134	1.359e-41	175.0	COG1287@1|root,COG1287@2|Bacteria,2IF8Q@201174|Actinobacteria	201174|Actinobacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2088158_6	397278.JOJN01000003_gene1816	8.49e-29	122.0	COG3427@1|root,COG3427@2|Bacteria,2IK4M@201174|Actinobacteria,4DRP0@85009|Propionibacteriales	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
CMS3_k127_2088158_5	1211815.CBYP010000036_gene2307	5.268e-39	155.0	COG3764@1|root,COG3764@2|Bacteria,2IR30@201174|Actinobacteria,4EVPW@85013|Frankiales	201174|Actinobacteria	M	peptidase C60 sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
CMS3_k127_2088158_3	1385520.N802_03825	1.283e-52	196.0	arCOG06227@1|root,2ZCRG@2|Bacteria,2I96P@201174|Actinobacteria,4FE9G@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
CMS3_k127_2088158_2	1313172.YM304_29460	6.683e-62	224.0	COG5012@1|root,COG5012@2|Bacteria,2GKAY@201174|Actinobacteria	201174|Actinobacteria	S	Cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
CMS3_k127_2088158_4	1229780.BN381_450068	2.767e-51	188.0	COG1595@1|root,COG1595@2|Bacteria,2GP9D@201174|Actinobacteria,3UWW2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	ECF sigma factor	sigK	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_2088158_7	570268.ANBB01000037_gene2842	1.148e-13	81.0	COG5343@1|root,COG5343@2|Bacteria,2GUEC@201174|Actinobacteria	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA,zf-HC2
CMS3_k127_2088158_1	391625.PPSIR1_28283	7.877e-79	275.0	COG0204@1|root,COG0204@2|Bacteria,1RF5A@1224|Proteobacteria,4300N@68525|delta/epsilon subdivisions,2WVIK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
CMS3_k127_2088158_0	1229780.BN381_310034	2.833e-140	459.0	COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria,3UWGU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
CMS3_k127_2088158_8	1223542.GM1_049_00170	1.112e-10	64.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4GDAX@85026|Gordoniaceae	201174|Actinobacteria	IQ	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_2120538_5	105425.BBPL01000004_gene7603	1.695e-10	72.0	COG2020@1|root,COG2020@2|Bacteria,2IN0C@201174|Actinobacteria	201174|Actinobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CMS3_k127_2120538_1	861299.J421_1425	6.254e-78	269.0	COG0682@1|root,COG0682@2|Bacteria	2|Bacteria	M	lipoprotein biosynthetic process	-	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CMS3_k127_2120538_0	1206730.BAGA01000079_gene1310	1.36e-190	612.0	COG1964@1|root,COG1964@2|Bacteria,2I9RQ@201174|Actinobacteria,4FU0I@85025|Nocardiaceae	201174|Actinobacteria	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS3_k127_2120538_3	631362.Thi970DRAFT_00058	4.727e-36	145.0	COG3449@1|root,COG3449@2|Bacteria,1RF2U@1224|Proteobacteria,1S2JU@1236|Gammaproteobacteria,1WY8T@135613|Chromatiales	135613|Chromatiales	L	PFAM SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
CMS3_k127_2120538_4	1397278.AYMV01000016_gene2383	2.987e-13	83.0	COG0744@1|root,COG0810@1|root,COG2304@1|root,COG0744@2|Bacteria,COG0810@2|Bacteria,COG2304@2|Bacteria,2IB9H@201174|Actinobacteria,4FNP1@85023|Microbacteriaceae	201174|Actinobacteria	M	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,Gram_pos_anchor,VWA
CMS3_k127_2120538_6	1242864.D187_007437	0.0004784	51.0	2AKF7@1|root,31B6Q@2|Bacteria,1N34J@1224|Proteobacteria,42WRW@68525|delta/epsilon subdivisions,2WRCW@28221|Deltaproteobacteria,2YV18@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2120538_2	886293.Sinac_0216	2.448e-42	170.0	COG4655@1|root,COG4655@2|Bacteria,2J54T@203682|Planctomycetes	203682|Planctomycetes	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2124216_3	1042326.AZNV01000067_gene5651	2.811e-18	99.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,4BEA9@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Hint_2
CMS3_k127_2124216_1	216594.MMAR_0242	3.041e-38	162.0	COG0657@1|root,COG0823@1|root,COG0657@2|Bacteria,COG0823@2|Bacteria,2I40M@201174|Actinobacteria,233DD@1762|Mycobacteriaceae	201174|Actinobacteria	U	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PE
CMS3_k127_2124216_0	322710.Avin_44900	3.472e-303	957.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0339	Transketolase_N
CMS3_k127_2124216_2	1278073.MYSTI_01792	9.899e-24	115.0	COG2885@1|root,COG3055@1|root,COG2885@2|Bacteria,COG3055@2|Bacteria,1R4WG@1224|Proteobacteria,42TD5@68525|delta/epsilon subdivisions,2WP3U@28221|Deltaproteobacteria,2YZ06@29|Myxococcales	28221|Deltaproteobacteria	M	HYR domain	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	HYR,Kelch_4,OMP_b-brl,OmpA,TSP_3
CMS3_k127_2124216_4	1328313.DS2_13979	0.0008042	51.0	COG2152@1|root,COG2152@2|Bacteria,1R84Z@1224|Proteobacteria,1S04H@1236|Gammaproteobacteria,46640@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
CMS3_k127_2137279_1	1313172.YM304_07490	4.629e-108	355.0	COG0479@1|root,COG0479@2|Bacteria,2GP9C@201174|Actinobacteria,4CNED@84992|Acidimicrobiia	84992|Acidimicrobiia	C	2Fe-2S iron-sulfur cluster binding domain	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3
CMS3_k127_2137279_0	357808.RoseRS_2399	2.863e-304	946.0	COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi,374WX@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CMS3_k127_2137279_2	1313172.YM304_07470	2.177e-12	68.0	28HIR@1|root,2Z7U4@2|Bacteria,2GN2S@201174|Actinobacteria	201174|Actinobacteria	S	succinate dehydrogenase	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
CMS3_k127_2141037_2	1254432.SCE1572_05580	1.008e-125	415.0	COG2303@1|root,COG2303@2|Bacteria,1NV3A@1224|Proteobacteria,42NVR@68525|delta/epsilon subdivisions,2X5KZ@28221|Deltaproteobacteria,2Z346@29|Myxococcales	28221|Deltaproteobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
CMS3_k127_2141037_1	472759.Nhal_1703	9.908e-131	434.0	COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria	1224|Proteobacteria	C	radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS3_k127_2141037_0	1041159.AZUW01000009_gene4518	2.604e-173	559.0	COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria,2VGDJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
CMS3_k127_2141037_3	765911.Thivi_4549	1.939e-66	236.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1WX63@135613|Chromatiales	135613|Chromatiales	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
CMS3_k127_2141037_4	234267.Acid_0571	1.519e-26	117.0	COG0346@1|root,COG0346@2|Bacteria,3Y85T@57723|Acidobacteria	57723|Acidobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_2169272_7	443218.AS9A_3196	1.433e-81	276.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,234DZ@1762|Mycobacteriaceae	201174|Actinobacteria	H	Acetolactate synthase, large subunit	ilvB	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030312,GO:0030976,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3003c	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_2169272_10	706587.Desti_0050	1.321e-41	167.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,42RRU@68525|delta/epsilon subdivisions,2WNBY@28221|Deltaproteobacteria,2MS2R@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	TIGRFAM acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
CMS3_k127_2169272_4	404589.Anae109_1879	2.661e-136	443.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2YU99@29|Myxococcales	28221|Deltaproteobacteria	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
CMS3_k127_2169272_1	1121422.AUMW01000006_gene800	2.272e-159	518.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia,260GB@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
CMS3_k127_2169272_2	344747.PM8797T_28999	4.504e-158	506.0	COG0473@1|root,COG0473@2|Bacteria,2IXJZ@203682|Planctomycetes	203682|Planctomycetes	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CMS3_k127_2169272_5	1464048.JNZS01000037_gene4716	1.235e-110	375.0	COG0308@1|root,COG0308@2|Bacteria,2GJWF@201174|Actinobacteria,4D90U@85008|Micromonosporales	201174|Actinobacteria	E	Peptidase M1 membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
CMS3_k127_2169272_12	176946.XP_007419963.1	3.209e-33	140.0	COG0329@1|root,2QWNS@2759|Eukaryota,399HY@33154|Opisthokonta,3BGNT@33208|Metazoa,3CUM9@33213|Bilateria,481FN@7711|Chordata,48XJ6@7742|Vertebrata	33208|Metazoa	E	4-hydroxy-2-oxoglutarate aldolase activity	HOGA1	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006081,GO:0006082,GO:0006090,GO:0006520,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008700,GO:0009056,GO:0009058,GO:0009063,GO:0009436,GO:0009987,GO:0016053,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0016833,GO:0019470,GO:0019471,GO:0019752,GO:0031974,GO:0032787,GO:0033609,GO:0042219,GO:0042802,GO:0042803,GO:0042866,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046185,GO:0046394,GO:0046395,GO:0046487,GO:0046983,GO:0070013,GO:0071704,GO:0072329,GO:0072330,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901605,GO:1901606	4.1.3.16	ko:K18123	ko00330,ko00630,ko01100,map00330,map00630,map01100	-	R00470,R00471	RC00307,RC00308	ko00000,ko00001,ko01000	-	-	-	DHDPS
CMS3_k127_2169272_16	42256.RradSPS_0276	3.6e-12	75.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
CMS3_k127_2169272_17	526224.Bmur_1030	0.0004827	43.0	COG1595@1|root,COG1595@2|Bacteria,2J7DE@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_2169272_15	1120948.KB903227_gene4887	1.182e-16	89.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4E3X3@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
CMS3_k127_2169272_6	449447.MAE_61960	3.235e-91	313.0	COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria	1117|Cyanobacteria	C	NAD(P) transhydrogenase, alpha subunit	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
CMS3_k127_2169272_13	1121104.AQXH01000001_gene1925	1.203e-28	118.0	COG3288@1|root,COG3288@2|Bacteria,4NT78@976|Bacteroidetes	976|Bacteroidetes	C	Pyridine nucleotide transhydrogenase	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
CMS3_k127_2169272_3	221288.JH992901_gene2984	1.884e-140	459.0	COG1282@1|root,COG1282@2|Bacteria,1G2AX@1117|Cyanobacteria,1JHQ2@1189|Stigonemataceae	1117|Cyanobacteria	C	NAD(P) transhydrogenase beta subunit	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
CMS3_k127_2169272_11	345341.KUTG_02879	8.231e-40	156.0	COG0778@1|root,COG0778@2|Bacteria,2GW57@201174|Actinobacteria,4E2QV@85010|Pseudonocardiales	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS3_k127_2169272_0	1229780.BN381_50151	1.41e-166	537.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,3UWE6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
CMS3_k127_2169272_8	452652.KSE_29460	2.802e-65	234.0	COG0122@1|root,COG0122@2|Bacteria,2GP69@201174|Actinobacteria,2M2IA@2063|Kitasatospora	201174|Actinobacteria	L	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2169272_14	888050.HMPREF9004_0722	1.348e-17	92.0	2EGCD@1|root,33A46@2|Bacteria,2I66V@201174|Actinobacteria,4D5QZ@85005|Actinomycetales	201174|Actinobacteria	S	Septum formation	-	-	-	-	-	-	-	-	-	-	-	-	Septum_form
CMS3_k127_2169272_9	1089545.KB913037_gene283	2.383e-43	167.0	COG2050@1|root,COG2050@2|Bacteria,2HMKZ@201174|Actinobacteria,4E163@85010|Pseudonocardiales	201174|Actinobacteria	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
CMS3_k127_2170637_15	864563.HMPREF9166_1635	2.109e-20	91.0	COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,4H5K3@909932|Negativicutes	909932|Negativicutes	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
CMS3_k127_2170637_10	1449126.JQKL01000038_gene978	5.037e-35	145.0	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,267IV@186813|unclassified Clostridiales	186801|Clostridia	U	60Kd inner membrane protein	oxaA	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
CMS3_k127_2170637_12	525909.Afer_2034	5.149e-31	137.0	COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria,4CN3J@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Putative single-stranded nucleic acids-binding domain	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,R3H
CMS3_k127_2170637_14	1487956.DR71_1062	1.148e-21	103.0	COG0357@1|root,COG0357@2|Bacteria,2GM9Z@201174|Actinobacteria,22KRA@1653|Corynebacteriaceae	201174|Actinobacteria	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
CMS3_k127_2170637_4	1313172.YM304_42850	2.396e-100	334.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4CMSR@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS3_k127_2170637_6	1313172.YM304_42840	2.208e-77	269.0	COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4CMXK@84992|Acidimicrobiia	84992|Acidimicrobiia	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
CMS3_k127_2170637_9	298655.KI912266_gene1159	1.379e-39	160.0	COG0860@1|root,COG3409@1|root,COG0860@2|Bacteria,COG3409@2|Bacteria,2GPA9@201174|Actinobacteria,4ERBQ@85013|Frankiales	201174|Actinobacteria	M	Cell wall hydrolase autolysin	cwlM	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,PG_binding_1
CMS3_k127_2170637_11	1172185.KB911513_gene4470	1.499e-32	129.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4G24Y@85025|Nocardiaceae	201174|Actinobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS3_k127_2170637_1	525904.Tter_1226	2.731e-128	416.0	COG0492@1|root,COG0492@2|Bacteria,2NNS7@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2
CMS3_k127_2170637_7	675635.Psed_6676	1.287e-42	164.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4DXS2@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigM	GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_2170637_16	35754.JNYJ01000013_gene1182	7.942e-13	81.0	COG0515@1|root,COG0515@2|Bacteria,2GM4A@201174|Actinobacteria,4DA7V@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_2170637_17	1121877.JQKF01000017_gene201	2.485e-11	73.0	COG0454@1|root,COG0456@2|Bacteria,2HGG5@201174|Actinobacteria,4CNDG@84992|Acidimicrobiia	84992|Acidimicrobiia	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_2170637_5	1313172.YM304_28170	9.369e-84	293.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4CMXH@84992|Acidimicrobiia	84992|Acidimicrobiia	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
CMS3_k127_2170637_13	1048339.KB913029_gene4331	1.115e-28	132.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4EUBH@85013|Frankiales	201174|Actinobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
CMS3_k127_2170637_3	767817.Desgi_4193	1.553e-100	358.0	COG4640@1|root,COG4640@2|Bacteria,1TQ9M@1239|Firmicutes,24DDM@186801|Clostridia,264D0@186807|Peptococcaceae	186801|Clostridia	S	DUF3160	-	-	-	-	-	-	-	-	-	-	-	-	DUF3160,zinc_ribbon_2
CMS3_k127_2170637_2	351607.Acel_0550	5.839e-118	392.0	COG2805@1|root,COG2805@2|Bacteria,2HPWY@201174|Actinobacteria,4EUA1@85013|Frankiales	201174|Actinobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS3_k127_2170637_8	195250.CM001776_gene2075	7.588e-41	158.0	COG0328@1|root,COG0328@2|Bacteria,1G12J@1117|Cyanobacteria,1GYK3@1129|Synechococcus	1117|Cyanobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
CMS3_k127_2170637_0	1313172.YM304_42710	4.736e-152	494.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria,4CMV5@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
CMS3_k127_2208466_6	479431.Namu_0079	2.081e-30	138.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,4ERJZ@85013|Frankiales	201174|Actinobacteria	M	PFAM penicillin-binding protein transpeptidase	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
CMS3_k127_2208466_1	526225.Gobs_0038	1.06e-80	289.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,4ERWV@85013|Frankiales	201174|Actinobacteria	D	Belongs to the SEDS family	rodA	GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
CMS3_k127_2208466_5	525909.Afer_0090	3.858e-48	181.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4CN1S@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
CMS3_k127_2208466_8	479434.Sthe_1694	1.722e-18	90.0	COG1716@1|root,COG1716@2|Bacteria,2G759@200795|Chloroflexi,27YBI@189775|Thermomicrobia	189775|Thermomicrobia	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
CMS3_k127_2208466_7	1229780.BN381_70015	1.472e-19	98.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,3UWPZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	T	Protein of unknown function (DUF2662)	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
CMS3_k127_2208466_4	1068978.AMETH_6468	5.418e-49	189.0	COG0500@1|root,COG2226@2|Bacteria,2IP4P@201174|Actinobacteria,4E5RD@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_2208466_9	1192034.CAP_8672	3.162e-16	91.0	COG2905@1|root,COG3202@1|root,COG2905@2|Bacteria,COG3202@2|Bacteria,1RERN@1224|Proteobacteria	1224|Proteobacteria	T	Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
CMS3_k127_2208466_0	1122182.KB903833_gene5401	3.368e-114	408.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4DBEY@85008|Micromonosporales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
CMS3_k127_2208466_2	1146883.BLASA_1649	1.591e-58	211.0	COG0491@1|root,COG0491@2|Bacteria,2GJ6X@201174|Actinobacteria,4EWIR@85013|Frankiales	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_2208466_3	1463821.JOGR01000011_gene2182	3.358e-53	190.0	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
CMS3_k127_2249883_6	118166.JH976537_gene1745	4.015e-10	66.0	COG4663@1|root,COG4663@2|Bacteria,1G1BA@1117|Cyanobacteria,1H7NS@1150|Oscillatoriales	1117|Cyanobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	GO:0003674,GO:0005215,GO:0005342,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0015849,GO:0022857,GO:0031317,GO:0032991,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0046983,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:1903825,GO:1990351	-	-	-	-	-	-	-	-	-	-	DctP
CMS3_k127_2249883_0	926550.CLDAP_06650	6.861e-133	445.0	COG4664@1|root,COG4664@2|Bacteria,2G81X@200795|Chloroflexi	200795|Chloroflexi	Q	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
CMS3_k127_2249883_3	1487953.JMKF01000067_gene3903	1.496e-32	136.0	COG4665@1|root,COG4665@2|Bacteria,1G19Z@1117|Cyanobacteria,1HEKH@1150|Oscillatoriales	1117|Cyanobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
CMS3_k127_2249883_8	667632.KB890170_gene3689	1.46e-06	61.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VJ9G@28216|Betaproteobacteria,1K0VU@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	degQ	-	-	ko:K04691,ko:K04772	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_2249883_7	344747.PM8797T_21448	1.196e-06	60.0	COG1466@1|root,COG1466@2|Bacteria,2IZVJ@203682|Planctomycetes	203682|Planctomycetes	L	DNA polymerase III, delta' subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
CMS3_k127_2249883_1	1232410.KI421421_gene3516	2.58e-112	388.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,42PB7@68525|delta/epsilon subdivisions,2WJX5@28221|Deltaproteobacteria,43U6C@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Mycolic acid cyclopropane synthetase	cfa1	-	2.1.1.317,2.1.1.79	ko:K00574,ko:K20238	-	-	-	-	ko00000,ko01000	-	-	iAF987.Gmet_2187	CMAS
CMS3_k127_2249883_2	1449058.JQKT01000007_gene1363	2.173e-61	238.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4FMUX@85023|Microbacteriaceae	201174|Actinobacteria	S	Competence protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
CMS3_k127_2249883_4	1120959.ATXF01000008_gene520	7.881e-30	126.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4FPAM@85023|Microbacteriaceae	201174|Actinobacteria	L	SLBB domain	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
CMS3_k127_2249883_5	1194972.MVAC_10222	8.069e-12	77.0	COG1266@1|root,COG1266@2|Bacteria,2IFZI@201174|Actinobacteria,232E1@1762|Mycobacteriaceae	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
CMS3_k127_2264783_0	1229780.BN381_10084	1.845e-193	624.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,3UW7F@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
CMS3_k127_2264783_1	1125863.JAFN01000001_gene555	2.106e-93	318.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2WK6B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
CMS3_k127_2264783_2	1120973.AQXL01000135_gene1397	3.09e-85	302.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,4HA6H@91061|Bacilli,277ZB@186823|Alicyclobacillaceae	91061|Bacilli	E	Aminotransferase class-V	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS3_k127_2264783_3	1123023.JIAI01000007_gene1945	4.3e-50	180.0	COG0346@1|root,COG0346@2|Bacteria,2IQB4@201174|Actinobacteria,4E5FV@85010|Pseudonocardiales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2264783_5	1463841.JOIR01000031_gene6469	5.312e-19	95.0	COG0695@1|root,COG0695@2|Bacteria,2IQF9@201174|Actinobacteria	201174|Actinobacteria	O	Glutaredoxin	-	-	1.20.4.3	ko:K18917	-	-	-	-	ko00000,ko01000	-	-	-	Glutaredoxin
CMS3_k127_2264783_4	864702.OsccyDRAFT_2779	1.291e-41	158.0	COG0454@1|root,COG0456@2|Bacteria,1G5EH@1117|Cyanobacteria	1117|Cyanobacteria	K	PFAM Acetyltransferase (GNAT) family	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
CMS3_k127_2264783_6	1121378.KB899696_gene2638	0.0006693	43.0	COG1073@1|root,COG1073@2|Bacteria,1WKS0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Prolyl oligopeptidase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S9
CMS3_k127_2301399_0	561175.KB894093_gene3269	2.3e-05	57.0	COG3147@1|root,COG3147@2|Bacteria,2ID4R@201174|Actinobacteria,4EHHH@85012|Streptosporangiales	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2366458_2	1313172.YM304_12080	1.977e-158	514.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF3179
CMS3_k127_2366458_6	1179773.BN6_18910	3.951e-44	166.0	COG5646@1|root,COG5646@2|Bacteria,2IMR2@201174|Actinobacteria,4E5VC@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
CMS3_k127_2366458_5	105425.BBPL01000044_gene3175	2.848e-68	238.0	COG1878@1|root,COG1878@2|Bacteria,2I66K@201174|Actinobacteria,2NH8N@228398|Streptacidiphilus	201174|Actinobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
CMS3_k127_2366458_1	710111.FraQA3DRAFT_0829	2.266e-161	539.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria,4EXBT@85013|Frankiales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_2366458_3	981369.JQMJ01000004_gene6141	3.672e-101	338.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,2NGR6@228398|Streptacidiphilus	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_2366458_0	331869.BAL199_19291	1.757e-196	621.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2TQW9@28211|Alphaproteobacteria,4BPBP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	MA20_21405	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
CMS3_k127_2366458_4	652103.Rpdx1_3957	1.193e-69	244.0	COG2267@1|root,COG2267@2|Bacteria,1Q6AF@1224|Proteobacteria,2U163@28211|Alphaproteobacteria,3JSQF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	MA20_21410	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
CMS3_k127_2366458_7	1198452.Jab_2c34270	1.226e-43	164.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2VMB3@28216|Betaproteobacteria,4779T@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_2418041_6	479431.Namu_1713	3.483e-81	301.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,4EV46@85013|Frankiales	201174|Actinobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
CMS3_k127_2418041_2	1206732.BAGD01000277_gene6244	7.719e-135	450.0	COG3540@1|root,COG3540@2|Bacteria,2IMZY@201174|Actinobacteria	201174|Actinobacteria	P	PhoD-like phosphatase	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD
CMS3_k127_2418041_9	2074.JNYD01000015_gene4434	4.902e-10	69.0	COG1011@1|root,COG1011@2|Bacteria,2IN1K@201174|Actinobacteria,4EEX5@85010|Pseudonocardiales	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
CMS3_k127_2418041_5	1082933.MEA186_31036	1.105e-84	301.0	COG2114@1|root,COG4192@1|root,COG2114@2|Bacteria,COG4192@2|Bacteria,1MV1V@1224|Proteobacteria,2U2BQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	PFAM adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,PAS_7
CMS3_k127_2418041_1	1246995.AFR_00915	2.792e-151	492.0	COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria,4D9EC@85008|Micromonosporales	201174|Actinobacteria	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
CMS3_k127_2418041_11	103733.JNYO01000076_gene6416	0.000127	52.0	COG2931@1|root,COG4447@1|root,COG2931@2|Bacteria,COG4447@2|Bacteria,2HSAI@201174|Actinobacteria,4ED2E@85010|Pseudonocardiales	201174|Actinobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2418041_4	1192034.CAP_6685	1.209e-104	352.0	COG0477@1|root,COG2814@2|Bacteria,1PFB3@1224|Proteobacteria,42N9W@68525|delta/epsilon subdivisions,2WJW0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_2418041_0	35754.JNYJ01000064_gene1412	4.071e-214	712.0	COG1112@1|root,COG1198@1|root,COG1112@2|Bacteria,COG1198@2|Bacteria,2GKJW@201174|Actinobacteria,4DBGN@85008|Micromonosporales	201174|Actinobacteria	L	Superfamily I DNA and RNA helicases and helicase subunits	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF3320,DUF4011,DUF559
CMS3_k127_2418041_7	118173.KB235914_gene3902	5.043e-72	254.0	COG1215@1|root,COG1215@2|Bacteria,1G5YB@1117|Cyanobacteria,1HB60@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_2418041_8	2045.KR76_04380	2.366e-12	72.0	COG1714@1|root,COG1714@2|Bacteria,2I056@201174|Actinobacteria,4DVSM@85009|Propionibacteriales	201174|Actinobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
CMS3_k127_2418041_3	290400.Jann_3792	7.828e-111	371.0	28MZG@1|root,2ZB66@2|Bacteria,1R6ZF@1224|Proteobacteria,2U3DX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
CMS3_k127_2418041_10	391612.CY0110_14003	5.733e-06	56.0	2E3GU@1|root,32YFI@2|Bacteria,1G9HI@1117|Cyanobacteria,3KIKQ@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2459305_2	208439.AJAP_15650	2.277e-18	98.0	COG4733@1|root,COG4733@2|Bacteria,2GNV7@201174|Actinobacteria,4E4T7@85010|Pseudonocardiales	201174|Actinobacteria	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
CMS3_k127_2459305_1	404589.Anae109_1741	1.019e-44	171.0	COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,42RNH@68525|delta/epsilon subdivisions,2X5NY@28221|Deltaproteobacteria,2Z0TQ@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	-	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
CMS3_k127_2459305_0	1313172.YM304_16080	3.825e-105	353.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4CMSF@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,S1
CMS3_k127_2500323_1	1254432.SCE1572_36400	1.487e-08	56.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,42PXQ@68525|delta/epsilon subdivisions,2WKHU@28221|Deltaproteobacteria,2YZ37@29|Myxococcales	28221|Deltaproteobacteria	L	COG1484 DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
CMS3_k127_2500323_0	1144275.COCOR_01518	2.68e-09	70.0	COG4932@1|root,COG4932@2|Bacteria,1R5S8@1224|Proteobacteria	1224|Proteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_2529888_0	314230.DSM3645_08111	1.132e-09	70.0	COG4932@1|root,COG4932@2|Bacteria,2IYDU@203682|Planctomycetes	203682|Planctomycetes	M	Cna B domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
CMS3_k127_2542128_15	391037.Sare_1168	8.961e-07	56.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4D8DT@85008|Micromonosporales	201174|Actinobacteria	S	Dak phosphatase	dak3	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
CMS3_k127_2542128_10	309801.trd_A0581	1.662e-21	104.0	COG0344@1|root,COG0344@2|Bacteria,2GBUF@200795|Chloroflexi,27ZAT@189775|Thermomicrobia	189775|Thermomicrobia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
CMS3_k127_2542128_13	1121377.KB906398_gene2024	3.193e-13	82.0	COG1307@1|root,COG1307@2|Bacteria,1WIY0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
CMS3_k127_2542128_8	981369.JQMJ01000004_gene6483	5.187e-28	128.0	COG1073@1|root,COG1073@2|Bacteria,2GNUS@201174|Actinobacteria,2NEQE@228398|Streptacidiphilus	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
CMS3_k127_2542128_4	1120936.KB907217_gene3664	8.13e-42	161.0	COG2917@1|root,COG2917@2|Bacteria,2IGTQ@201174|Actinobacteria,4EIRE@85012|Streptosporangiales	201174|Actinobacteria	D	probably involved in intracellular septation	-	-	-	-	-	-	-	-	-	-	-	-	DUF3159,IspA
CMS3_k127_2542128_9	469371.Tbis_0632	6.363e-26	115.0	COG0500@1|root,COG2226@2|Bacteria,2IP2P@201174|Actinobacteria,4E4WW@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS3_k127_2542128_3	1054860.KB913030_gene6340	3.454e-52	198.0	COG0697@1|root,COG0697@2|Bacteria,2I9UQ@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_2542128_17	247490.KSU1_B0185	0.0003797	46.0	COG2846@1|root,COG2846@2|Bacteria,2J23U@203682|Planctomycetes	203682|Planctomycetes	D	NnrS protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858,NnrS
CMS3_k127_2542128_16	1116232.AHBF01000137_gene1924	0.0001506	51.0	2AYAN@1|root,31QD6@2|Bacteria,2H0HE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2542128_11	713586.KB900536_gene328	1.379e-20	98.0	COG2133@1|root,COG2133@2|Bacteria,1QWB2@1224|Proteobacteria	1224|Proteobacteria	G	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
CMS3_k127_2542128_7	1304865.JAGF01000001_gene1006	4.803e-36	144.0	COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria	201174|Actinobacteria	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
CMS3_k127_2542128_2	1283283.ATXA01000003_gene1646	1.393e-52	190.0	COG1595@1|root,COG1595@2|Bacteria,2IKQ7@201174|Actinobacteria,4EVJY@85013|Frankiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_2542128_12	479431.Namu_2023	6.628e-17	90.0	2DW3A@1|root,33YCP@2|Bacteria,2GZ8M@201174|Actinobacteria,4EVKN@85013|Frankiales	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
CMS3_k127_2542128_5	929712.KI912613_gene4900	7.216e-41	157.0	COG1309@1|root,COG1309@2|Bacteria,2I31S@201174|Actinobacteria,4CQHW@84995|Rubrobacteria	84995|Rubrobacteria	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
CMS3_k127_2542128_1	1123322.KB904668_gene3740	8.683e-65	231.0	COG2267@1|root,COG2267@2|Bacteria,2GQC1@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
CMS3_k127_2542128_6	1869.MB27_30450	2.751e-36	152.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria	201174|Actinobacteria	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
CMS3_k127_2542128_14	65672.G4TSF5	2.788e-08	62.0	KOG4155@1|root,KOG4155@2759|Eukaryota,3AG0Y@33154|Opisthokonta,3Q4RG@4751|Fungi,3V38M@5204|Basidiomycota,22FDX@155619|Agaricomycetes,3H92M@355688|Agaricomycetes incertae sedis	4751|Fungi	S	WD40 repeat-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,NACHT,WD40
CMS3_k127_2542128_0	1122138.AQUZ01000008_gene3766	1.532e-65	226.0	COG0662@1|root,COG0662@2|Bacteria,2IRGP@201174|Actinobacteria	201174|Actinobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_2567781_1	1122622.ATWJ01000001_gene2380	7.514e-81	274.0	COG0202@1|root,COG0202@2|Bacteria,2GJJ5@201174|Actinobacteria,4FF7C@85021|Intrasporangiaceae	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
CMS3_k127_2567781_2	1206741.BAFX01000023_gene8088	2.686e-70	244.0	COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria,4FXBP@85025|Nocardiaceae	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
CMS3_k127_2567781_6	1245475.ANAE01000082_gene1941	1.81e-45	170.0	COG0100@1|root,COG0100@2|Bacteria,2IFFC@201174|Actinobacteria,4EIR3@85012|Streptosporangiales	201174|Actinobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
CMS3_k127_2567781_5	1121877.JQKF01000009_gene526	6.917e-52	187.0	COG0099@1|root,COG0099@2|Bacteria,2IHPN@201174|Actinobacteria,4CN1Z@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
CMS3_k127_2567781_8	64471.sync_0417	3.699e-14	72.0	COG0257@1|root,COG0257@2|Bacteria,1GAEI@1117|Cyanobacteria,1H1ZF@1129|Synechococcus	1117|Cyanobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
CMS3_k127_2567781_7	1121929.KB898666_gene2576	1.457e-29	129.0	COG0454@1|root,COG0456@2|Bacteria,1V37I@1239|Firmicutes,4HGJH@91061|Bacilli	91061|Bacilli	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_2567781_0	1120973.AQXL01000112_gene1094	2.05e-83	286.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,4H9S9@91061|Bacilli,277XD@186823|Alicyclobacillaceae	91061|Bacilli	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
CMS3_k127_2567781_4	1120948.KB903217_gene1569	1.047e-52	191.0	COG0563@1|root,COG0563@2|Bacteria,2GJ7T@201174|Actinobacteria,4DXX8@85010|Pseudonocardiales	201174|Actinobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0000166,GO:0003674,GO:0003824,GO:0004017,GO:0004550,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006144,GO:0006163,GO:0006164,GO:0006165,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009141,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032261,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043094,GO:0043101,GO:0043167,GO:0043168,GO:0043173,GO:0044209,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK
CMS3_k127_2567781_3	1121877.JQKF01000009_gene529	3.347e-70	245.0	COG0201@1|root,COG0201@2|Bacteria,2GJ26@201174|Actinobacteria,4CMWZ@84992|Acidimicrobiia	84992|Acidimicrobiia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
CMS3_k127_2588007_0	469383.Cwoe_2724	0.0	1064.0	COG0376@1|root,COG0376@2|Bacteria,2GJFP@201174|Actinobacteria,4CRMG@84995|Rubrobacteria	84995|Rubrobacteria	P	Peroxidase	-	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
CMS3_k127_2604483_2	649638.Trad_2776	7.375e-52	193.0	COG3346@1|root,COG3346@2|Bacteria	2|Bacteria	S	mitochondrial respiratory chain complex IV assembly	surf1	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
CMS3_k127_2604483_4	1380347.JNII01000007_gene526	1.167e-29	127.0	COG3860@1|root,COG3860@2|Bacteria,2IQEK@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2087)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087,HTH_20
CMS3_k127_2604483_3	926569.ANT_00910	1.99e-31	138.0	COG0406@1|root,COG0406@2|Bacteria,2G73Q@200795|Chloroflexi	200795|Chloroflexi	G	PFAM Phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
CMS3_k127_2604483_6	926569.ANT_04570	2.553e-21	99.0	298YA@1|root,2ZW25@2|Bacteria,2G6UQ@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
CMS3_k127_2604483_1	1380346.JNIH01000017_gene5424	1.674e-55	205.0	COG5032@1|root,COG5032@2|Bacteria,2GME7@201174|Actinobacteria	201174|Actinobacteria	BDLTU	Phosphatidylinositol	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2604483_0	1541065.JRFE01000001_gene2604	5.284e-140	460.0	COG0405@1|root,COG0405@2|Bacteria,1G20A@1117|Cyanobacteria,3VJBY@52604|Pleurocapsales	1117|Cyanobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CMS3_k127_2604483_7	1121946.AUAX01000027_gene8016	1.241e-12	79.0	COG0457@1|root,COG0457@2|Bacteria,2GKX5@201174|Actinobacteria,4D9EM@85008|Micromonosporales	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
CMS3_k127_2604483_8	1122925.KB895403_gene173	8.467e-11	65.0	2DJMR@1|root,306KE@2|Bacteria,1TZYH@1239|Firmicutes,4I982@91061|Bacilli,2715K@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2604483_5	591157.SSLG_00641	2.508e-22	98.0	2EPJ6@1|root,33H5U@2|Bacteria,2IT42@201174|Actinobacteria	201174|Actinobacteria	S	Unextendable partial coding region	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2619250_14	1151117.AJLF01000001_gene873	8.905e-10	65.0	COG0624@1|root,arCOG01107@2157|Archaea,2XSTW@28890|Euryarchaeota,242JR@183968|Thermococci	183968|Thermococci	E	Acetylornithine deacetylase	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS3_k127_2619250_7	706587.Desti_4386	8.188e-53	203.0	28HF7@1|root,2Z7RC@2|Bacteria,1R7YU@1224|Proteobacteria,42QFU@68525|delta/epsilon subdivisions,2WM3B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Glycine/sarcosine/betaine reductase component B subunits	-	-	1.21.4.2	ko:K10671	-	-	-	-	ko00000,ko01000	-	-	-	Gly_reductase
CMS3_k127_2619250_4	246194.CHY_2393	1.61e-89	314.0	COG1978@1|root,COG1978@2|Bacteria,1TPAB@1239|Firmicutes,2487X@186801|Clostridia,42HVI@68295|Thermoanaerobacterales	186801|Clostridia	C	Glycine reductase complex component B subunit gamma	grdB	-	1.21.4.2	ko:K10672	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
CMS3_k127_2619250_12	891968.Anamo_1616	7.036e-16	79.0	COG1978@1|root,COG1978@2|Bacteria,3TC4W@508458|Synergistetes	508458|Synergistetes	S	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	1.21.4.2	ko:K10672	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
CMS3_k127_2619250_3	1118054.CAGW01000024_gene481	1.315e-99	344.0	COG0332@1|root,COG0332@2|Bacteria,1TQSB@1239|Firmicutes,4HCJ1@91061|Bacilli	91061|Bacilli	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III
CMS3_k127_2619250_16	941824.TCEL_00715	2.34e-06	50.0	2AE14@1|root,313TT@2|Bacteria,1V6GX@1239|Firmicutes,24K4C@186801|Clostridia,36JTG@31979|Clostridiaceae	186801|Clostridia	C	In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination	grdA	-	1.21.4.2,1.21.4.3,1.21.4.4	ko:K10670	-	-	-	-	ko00000,ko01000	-	-	-	GRDA
CMS3_k127_2619250_10	457421.CBFG_00552	1.442e-27	114.0	2AE14@1|root,313TT@2|Bacteria,1V6GX@1239|Firmicutes,24K4C@186801|Clostridia	186801|Clostridia	C	In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination	grdA	-	1.21.4.2,1.21.4.3,1.21.4.4	ko:K10670	-	-	-	-	ko00000,ko01000	-	-	-	GRDA
CMS3_k127_2619250_0	1192034.CAP_5178	1.32e-192	616.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	malic protein domain protein	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
CMS3_k127_2619250_1	3983.cassava4.1_008693m	1.387e-146	477.0	COG0334@1|root,KOG2250@2759|Eukaryota,37Q3I@33090|Viridiplantae,3GC9F@35493|Streptophyta,4JRW9@91835|fabids	35493|Streptophyta	E	Belongs to the Glu Leu Phe Val dehydrogenases family	GDH2	GO:0000166,GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005773,GO:0005774,GO:0006950,GO:0006970,GO:0006995,GO:0007154,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009267,GO:0009268,GO:0009605,GO:0009628,GO:0009651,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010446,GO:0016020,GO:0016491,GO:0016638,GO:0016639,GO:0017076,GO:0030554,GO:0031090,GO:0031667,GO:0031668,GO:0031669,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0035639,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043562,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0046686,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0051716,GO:0055114,GO:0071496,GO:0097159,GO:0097367,GO:0098588,GO:0098805,GO:1901265,GO:1901363	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_2619250_2	1121918.ARWE01000001_gene2428	6.145e-103	349.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,42RXH@68525|delta/epsilon subdivisions,2WU0F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_2619250_15	1249627.D779_1669	4.261e-09	65.0	COG3647@1|root,COG3647@2|Bacteria,1RGJN@1224|Proteobacteria	1224|Proteobacteria	S	Membrane	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
CMS3_k127_2619250_5	356851.JOAN01000033_gene1822	1.436e-80	278.0	COG0745@1|root,COG0745@2|Bacteria,2GJRR@201174|Actinobacteria,4DCMD@85008|Micromonosporales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_2619250_6	356851.JOAN01000033_gene1823	1.424e-67	248.0	COG0642@1|root,COG2205@2|Bacteria,2GK1J@201174|Actinobacteria,4DB92@85008|Micromonosporales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07654	ko02020,map02020	M00461	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_2619250_9	479434.Sthe_0621	7.989e-39	162.0	COG5401@1|root,COG5401@2|Bacteria,2GA61@200795|Chloroflexi,27Y9M@189775|Thermomicrobia	189775|Thermomicrobia	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
CMS3_k127_2619250_13	555793.WSK_0104	4.133e-15	82.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
CMS3_k127_2619250_8	1122918.KB907263_gene356	1.587e-49	190.0	COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,4HE6D@91061|Bacilli,26RGF@186822|Paenibacillaceae	91061|Bacilli	M	enzyme of poly-gamma-glutamate biosynthesis (Capsule formation)	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
CMS3_k127_2619250_11	1123242.JH636434_gene4709	3.389e-27	115.0	COG0724@1|root,COG0724@2|Bacteria,2IZPY@203682|Planctomycetes	203682|Planctomycetes	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS3_k127_2623086_3	1313172.YM304_19370	1.035e-52	190.0	COG1403@1|root,COG1403@2|Bacteria,2GN1W@201174|Actinobacteria,4CN5M@84992|Acidimicrobiia	84992|Acidimicrobiia	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
CMS3_k127_2623086_4	656024.FsymDg_0858	1.269e-28	121.0	COG1846@1|root,COG1846@2|Bacteria,2IJHQ@201174|Actinobacteria,4ET44@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
CMS3_k127_2623086_2	1385521.N803_10485	1.649e-58	208.0	COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria,4FGNS@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
CMS3_k127_2623086_1	1043493.BBLU01000014_gene1348	1.503e-72	252.0	2F548@1|root,33XRC@2|Bacteria,2H5BG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2623086_5	1128912.GMES_1914	4.169e-22	109.0	COG3420@1|root,COG4932@1|root,COG5184@1|root,COG3420@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,1NGRY@1224|Proteobacteria,1T22S@1236|Gammaproteobacteria,467Z0@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	regulator of chromosome condensation, RCC1	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	CUB,Laminin_G_3
CMS3_k127_2623086_7	1123371.ATXH01000004_gene1694	5.378e-09	68.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,2GHX5@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
CMS3_k127_2623086_0	999547.KI421500_gene844	1.161e-171	542.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2TRW7@28211|Alphaproteobacteria,28072@191028|Leisingera	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	acuI	-	1.1.1.1	ko:K00001,ko:K19745	ko00010,ko00071,ko00350,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R00919,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00095,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_2623086_6	420324.KI912045_gene4622	6.168e-18	83.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2TTY5@28211|Alphaproteobacteria,1JTZJ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_2664656_1	697284.ERIC2_c15390	3.075e-32	128.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1TR8J@1239|Firmicutes,4H9XN@91061|Bacilli,26TYA@186822|Paenibacillaceae	91061|Bacilli	I	3-hydroxyacyl-CoA dehydrogenase	fadN	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU32840	3HCDH,3HCDH_N,ECH_1
CMS3_k127_2664656_0	639030.JHVA01000001_gene3849	5.182e-142	466.0	COG0183@1|root,COG0183@2|Bacteria,3Y2U4@57723|Acidobacteria,2JIS1@204432|Acidobacteriia	204432|Acidobacteriia	I	Thiolase, C-terminal domain	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_2670047_1	314345.SPV1_12917	9.248e-108	357.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria	1224|Proteobacteria	GK	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P	mak	GO:0003674,GO:0003824,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704	2.7.1.4,2.7.1.59	ko:K00847,ko:K00884	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R01201,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iECSE_1348.ECSE_0415,iEcHS_1320.EcHS_A0462,iPC815.YPO3211,iS_1188.S0338,iYL1228.KPN_00337	ROK
CMS3_k127_2670047_7	870187.Thini_1279	8.406e-78	268.0	COG1893@1|root,COG1893@2|Bacteria,1R60C@1224|Proteobacteria,1RZQZ@1236|Gammaproteobacteria,460EC@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2670047_14	1445613.JALM01000074_gene6760	2.475e-42	160.0	COG0748@1|root,COG0748@2|Bacteria,2I2TX@201174|Actinobacteria,4EDQN@85010|Pseudonocardiales	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red,Hemerythrin
CMS3_k127_2670047_0	749222.Nitsa_0867	1.896e-311	978.0	COG0474@1|root,COG0475@1|root,COG0474@2|Bacteria,COG0475@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YNQF@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	COG0474 Cation transport ATPase	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,Na_H_Exchanger
CMS3_k127_2670047_15	643648.Slip_0271	2.591e-40	160.0	COG2159@1|root,COG2159@2|Bacteria,1W7C3@1239|Firmicutes,258X6@186801|Clostridia,42KWF@68298|Syntrophomonadaceae	186801|Clostridia	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
CMS3_k127_2670047_13	525897.Dbac_2491	5.294e-47	178.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,42NRX@68525|delta/epsilon subdivisions,2WK1K@28221|Deltaproteobacteria,2M84Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	TIGRFAM Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0388	His_biosynth
CMS3_k127_2670047_16	1121272.KB903255_gene5810	1.628e-37	145.0	COG2001@1|root,COG2001@2|Bacteria,2IHUB@201174|Actinobacteria,4DD2W@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
CMS3_k127_2670047_6	428125.CLOLEP_02193	2.692e-81	282.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,3WH07@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
CMS3_k127_2670047_8	1122216.AUHW01000001_gene735	1.495e-77	281.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,4H207@909932|Negativicutes	909932|Negativicutes	M	Penicillin-binding protein, transpeptidase domain protein	ftsI	-	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
CMS3_k127_2670047_2	710111.FraQA3DRAFT_2862	1.552e-105	361.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4ES9W@85013|Frankiales	201174|Actinobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2158c	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS3_k127_2670047_5	526225.Gobs_3266	1.788e-84	297.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,4EREQ@85013|Frankiales	201174|Actinobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS3_k127_2670047_3	1229780.BN381_140011	1.829e-96	328.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,3UWA7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0008150,GO:0040007	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
CMS3_k127_2670047_10	710111.FraQA3DRAFT_2859	2.549e-63	240.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4ERI0@85013|Frankiales	201174|Actinobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2155c	AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M
CMS3_k127_2670047_9	574087.Acear_0745	2.915e-76	270.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,3WAGK@53433|Halanaerobiales	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
CMS3_k127_2670047_12	1089553.Tph_c12640	2.111e-50	194.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,42F8I@68295|Thermoanaerobacterales	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
CMS3_k127_2670047_4	1229781.C272_12919	6.567e-95	328.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4F8EK@85019|Brevibacteriaceae	201174|Actinobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS3_k127_2670047_11	661087.HMPREF1008_01634	4.18e-59	217.0	COG0812@1|root,COG0812@2|Bacteria,2GIV2@201174|Actinobacteria,4CUCU@84998|Coriobacteriia	84998|Coriobacteriia	M	Cell wall formation	murB_1	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
CMS3_k127_2670047_17	1414719.CBYN010000045_gene786	2.93e-06	54.0	COG1589@1|root,COG1589@2|Bacteria,2H4A4@201174|Actinobacteria,22MQI@1653|Corynebacteriaceae	201174|Actinobacteria	D	Cell division protein FtsQ	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
CMS3_k127_269292_10	1379698.RBG1_1C00001G1696	4.876e-05	49.0	COG0590@1|root,COG0590@2|Bacteria,2NPM7@2323|unclassified Bacteria	2|Bacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	3.5.4.1,3.5.4.33	ko:K01485,ko:K11991	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922,R10223	RC00074,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam
CMS3_k127_269292_3	1137268.AZXF01000008_gene2171	7.865e-71	250.0	COG0860@1|root,COG0860@2|Bacteria,2GPA9@201174|Actinobacteria,4EM6I@85012|Streptosporangiales	201174|Actinobacteria	M	Ami_3	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
CMS3_k127_269292_9	1121946.AUAX01000036_gene1923	3.607e-15	86.0	2DPD0@1|root,331J4@2|Bacteria,2IFZU@201174|Actinobacteria,4DCU1@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_269292_1	397278.JOJN01000011_gene1649	5.989e-172	563.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4DPPG@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
CMS3_k127_269292_5	1121897.AUGO01000002_gene2177	3.284e-59	236.0	COG1409@1|root,COG3211@1|root,COG1409@2|Bacteria,COG3211@2|Bacteria,4NJ5V@976|Bacteroidetes,1HY63@117743|Flavobacteriia,2NYF6@237|Flavobacterium	976|Bacteroidetes	S	Bacterial protein of unknown function (DUF839)	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
CMS3_k127_269292_6	926550.CLDAP_17510	3.675e-45	190.0	COG5337@1|root,COG5337@2|Bacteria	2|Bacteria	M	Spore coat protein CotH	-	-	-	-	-	-	-	-	-	-	-	-	CotH,LTD
CMS3_k127_269292_2	1206744.BAGL01000071_gene3382	8.576e-157	512.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4FYNR@85025|Nocardiaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
CMS3_k127_269292_0	1469245.JFBG01000007_gene658	3.19e-198	623.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,1RQ9E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	-	-	4.2.1.7,4.4.1.24	ko:K16846,ko:K16850	ko00040,ko00270,ko01100,map00040,map00270,map01100	M00631	R01540,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
CMS3_k127_269292_7	713586.KB900536_gene712	1.975e-40	152.0	COG2721@1|root,COG2721@2|Bacteria,1MZBN@1224|Proteobacteria	1224|Proteobacteria	G	altronate dehydratase	-	-	4.4.1.24	ko:K16845	ko00270,map00270	-	R07633	RC01785	ko00000,ko00001,ko01000	-	-	-	SAF
CMS3_k127_269292_8	710686.Mycsm_04583	1.053e-19	93.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_269292_4	1313172.YM304_11250	2.156e-63	242.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	ko:K02847	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	Wzy_C
CMS3_k127_270509_15	44060.JODL01000002_gene2183	1.389e-12	75.0	COG1595@1|root,COG1595@2|Bacteria,2GM6A@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_270509_5	1444712.BN1013_00667	5.14e-85	310.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	aidB	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
CMS3_k127_270509_9	1461693.ATO10_12604	5.992e-35	141.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2TUR9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
CMS3_k127_270509_0	886293.Sinac_2320	4.821e-194	617.0	COG1012@1|root,COG1012@2|Bacteria,2IXUZ@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_270509_11	1122975.AQVC01000061_gene210	1.638e-30	126.0	COG0251@1|root,COG0251@2|Bacteria,4NQ8M@976|Bacteroidetes,2FT8J@200643|Bacteroidia,22YB1@171551|Porphyromonadaceae	976|Bacteroidetes	J	Has endoribonuclease activity on mRNA	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
CMS3_k127_270509_3	1385518.N798_05500	9.248e-102	354.0	COG2304@1|root,COG2304@2|Bacteria,2IDJD@201174|Actinobacteria,4FJUD@85021|Intrasporangiaceae	201174|Actinobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
CMS3_k127_270509_12	1229780.BN381_100107	4.096e-27	115.0	COG0316@1|root,COG0316@2|Bacteria,2IHR0@201174|Actinobacteria,3UWKW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Iron-sulphur cluster biosynthesis	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
CMS3_k127_270509_2	1313172.YM304_38460	5.031e-102	345.0	COG0489@1|root,COG2151@1|root,COG0489@2|Bacteria,COG2151@2|Bacteria,2H1YI@201174|Actinobacteria,4CNPI@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
CMS3_k127_270509_8	1313172.YM304_31100	4.383e-36	152.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21471,ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	LysM,Peptidase_M23
CMS3_k127_270509_6	190650.CC_0923	4.205e-49	185.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria,2KFMD@204458|Caulobacterales	204458|Caulobacterales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_270509_10	1121106.JQKB01000013_gene5548	6.956e-31	132.0	COG0494@1|root,COG0494@2|Bacteria,1NTFG@1224|Proteobacteria,2U0I4@28211|Alphaproteobacteria,2JWPV@204441|Rhodospirillales	204441|Rhodospirillales	L	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_270509_13	1423144.Gal_03587	6.107e-27	114.0	COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,2UF72@28211|Alphaproteobacteria,34FER@302485|Phaeobacter	28211|Alphaproteobacteria	S	FxsA cytoplasmic membrane protein	fxsA	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
CMS3_k127_270509_4	1313172.YM304_38220	1.963e-89	317.0	COG1921@1|root,COG1921@2|Bacteria,2HFGK@201174|Actinobacteria	201174|Actinobacteria	E	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
CMS3_k127_270509_1	649831.L083_4397	7.489e-111	381.0	COG3276@1|root,COG3276@2|Bacteria,2GKF9@201174|Actinobacteria,4DBVC@85008|Micromonosporales	201174|Actinobacteria	J	Selenocysteine-specific translation elongation factor	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
CMS3_k127_270509_14	1229780.BN381_100117	1.054e-22	99.0	2CC1Y@1|root,32S23@2|Bacteria,2IQS5@201174|Actinobacteria,3UWYX@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB3	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
CMS3_k127_270509_7	1313172.YM304_38190	1.233e-37	151.0	COG1030@1|root,COG1030@2|Bacteria,2IATM@201174|Actinobacteria	201174|Actinobacteria	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
CMS3_k127_2718986_14	1366046.HIMB11_00637	7.512e-08	55.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TRUK@28211|Alphaproteobacteria,3ZGJE@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	E	Belongs to the peptidase M20A family. ArgE subfamily	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_2718986_12	1229780.BN381_400023	1.38e-12	74.0	COG0454@1|root,COG0456@2|Bacteria,2HBQK@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_2718986_5	1157943.KB892705_gene962	1.139e-70	247.0	COG0463@1|root,COG0463@2|Bacteria,2IPT1@201174|Actinobacteria,234JK@1762|Mycobacteriaceae	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	ppm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
CMS3_k127_2718986_16	656024.FsymDg_2569	0.0002592	49.0	2ATJW@1|root,3361K@2|Bacteria,2I80Y@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4193)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4193
CMS3_k127_2718986_10	552811.Dehly_0143	6.608e-35	145.0	COG1597@1|root,COG1597@2|Bacteria,2G6UK@200795|Chloroflexi,34CPQ@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
CMS3_k127_2718986_1	1120936.KB907219_gene3239	2.431e-183	607.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,4EH6A@85012|Streptosporangiales	201174|Actinobacteria	L	DSHCT	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
CMS3_k127_2718986_8	1313172.YM304_25980	6.149e-42	164.0	COG0805@1|root,COG0805@2|Bacteria,2GJK8@201174|Actinobacteria,4CN3F@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
CMS3_k127_2718986_15	357808.RoseRS_0983	1.112e-06	57.0	COG1826@1|root,COG1826@2|Bacteria,2G7D4@200795|Chloroflexi,377TB@32061|Chloroflexia	32061|Chloroflexia	U	PFAM sec-independent translocation protein mttA Hcf106	-	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
CMS3_k127_2718986_11	351607.Acel_1202	1.761e-13	74.0	2BZPH@1|root,33EX8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2718986_7	1229780.BN381_400038	4.961e-44	173.0	COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria,3UWZY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	WYL domain	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
CMS3_k127_2718986_9	1122611.KB904018_gene6993	3.313e-36	150.0	COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria,4EFRP@85012|Streptosporangiales	201174|Actinobacteria	K	WYL domain	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K13572,ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
CMS3_k127_2718986_2	1380394.JADL01000020_gene1826	1.792e-107	360.0	COG0742@1|root,COG0742@2|Bacteria,1MW6A@1224|Proteobacteria,2TQNI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	ribosomal rna small subunit methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2718986_0	1313172.YM304_26020	5.105e-222	697.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4CMS0@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	-	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
CMS3_k127_2718986_6	1121385.AQXW01000004_gene1255	1.225e-68	244.0	COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
CMS3_k127_2718986_4	1123065.ATWL01000001_gene471	1.679e-77	269.0	COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
CMS3_k127_2718986_13	1869.MB27_41385	1.617e-09	61.0	2E9C2@1|root,333JS@2|Bacteria,2IQ5V@201174|Actinobacteria,4DFMG@85008|Micromonosporales	201174|Actinobacteria	S	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation	pup	GO:0003674,GO:0005488,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0031386,GO:0032446,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044877,GO:0051603,GO:0070490,GO:0070628,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575	-	ko:K13570	-	-	-	-	ko00000,ko04121	-	-	-	Pup
CMS3_k127_2718986_3	2074.JNYD01000001_gene6131	8.755e-81	275.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4DZ25@85010|Pseudonocardiales	201174|Actinobacteria	S	proteasome accessory factor PafA2	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
CMS3_k127_2721880_8	1081644.IMCC13023_13430	2.232e-97	327.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4FQYT@85023|Microbacteriaceae	201174|Actinobacteria	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_2721880_3	1081644.IMCC13023_13420	2.926e-135	447.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4FNNK@85023|Microbacteriaceae	201174|Actinobacteria	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_2721880_10	1265502.KB905970_gene1298	6.224e-60	220.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2WHKK@28216|Betaproteobacteria,4AEQ6@80864|Comamonadaceae	28216|Betaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS3_k127_2721880_11	138119.DSY0967	5.362e-52	198.0	COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,24R48@186801|Clostridia,2637S@186807|Peptococcaceae	186801|Clostridia	S	PFAM Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
CMS3_k127_2721880_15	234267.Acid_1935	1.874e-09	68.0	COG0662@1|root,COG0662@2|Bacteria,3Y83R@57723|Acidobacteria	57723|Acidobacteria	G	Ectoine synthase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_2721880_9	1120983.KB894577_gene3578	1.772e-85	295.0	COG0673@1|root,COG0673@2|Bacteria,1PGFP@1224|Proteobacteria,2V8DN@28211|Alphaproteobacteria,1JQA3@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_2721880_1	469383.Cwoe_4085	8.342e-248	785.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
CMS3_k127_2721880_0	469383.Cwoe_4084	1.756e-297	921.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4CRNM@84995|Rubrobacteria	2|Bacteria	EQ	PFAM Hydantoinase B oxoprolinase	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
CMS3_k127_2721880_7	469383.Cwoe_4083	2.172e-102	342.0	COG1071@1|root,COG1071@2|Bacteria,2HVS4@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
CMS3_k127_2721880_6	469383.Cwoe_4082	1.968e-111	369.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4CRBS@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM Transketolase central region	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS3_k127_2721880_2	469383.Cwoe_4081	6.333e-136	440.0	COG1071@1|root,COG1071@2|Bacteria,2IC03@201174|Actinobacteria,4CQ7Q@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM dehydrogenase, E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
CMS3_k127_2721880_4	469383.Cwoe_4080	2.545e-133	432.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria	2|Bacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,E1_dh,Transket_pyr,Transketolase_C
CMS3_k127_2721880_14	1416759.AYMR01000011_gene402	2.521e-10	63.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria,4FMU7@85023|Microbacteriaceae	201174|Actinobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CMS3_k127_2721880_13	43354.JOIJ01000012_gene934	2.803e-14	81.0	COG2142@1|root,COG2142@2|Bacteria	2|Bacteria	C	succinate dehydrogenase activity	-	-	-	ko:K00242,ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
CMS3_k127_2721880_12	43354.JOIJ01000012_gene935	6.881e-34	137.0	COG2009@1|root,COG2009@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	-	-	-	ko:K00241,ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
CMS3_k127_2721880_5	1394178.AWOO02000006_gene3402	1.243e-114	381.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4EGQW@85012|Streptosporangiales	201174|Actinobacteria	C	Fumarate reductase flavoprotein C-term	-	-	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CMS3_k127_2769246_8	1268068.PG5_38550	0.000176	44.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2769246_2	1449347.JQLN01000004_gene6763	6.917e-83	293.0	COG0389@1|root,COG0389@2|Bacteria,2GMZ3@201174|Actinobacteria,2M1N6@2063|Kitasatospora	201174|Actinobacteria	L	impB/mucB/samB family	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
CMS3_k127_2769246_6	999411.HMPREF1092_00020	2.564e-30	130.0	COG0204@1|root,COG0204@2|Bacteria,1UMJA@1239|Firmicutes,249AV@186801|Clostridia,36EYB@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS3_k127_2769246_0	1313172.YM304_36840	1.893e-115	384.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria	201174|Actinobacteria	J	protein conserved in bacteria	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
CMS3_k127_2769246_1	1123023.JIAI01000002_gene4645	7.365e-96	323.0	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_2769246_5	649638.Trad_0235	3.296e-31	131.0	COG0212@1|root,COG0212@2|Bacteria,1WK90@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
CMS3_k127_2769246_4	457429.ABJI02000469_gene3370	4.891e-35	138.0	COG2606@1|root,COG2606@2|Bacteria,2IKUX@201174|Actinobacteria	201174|Actinobacteria	S	YbaK prolyl-tRNA synthetase associated region	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
CMS3_k127_2769246_3	1348338.ADILRU_1401	3.104e-66	230.0	COG1335@1|root,COG1335@2|Bacteria,2I77A@201174|Actinobacteria,4FNC6@85023|Microbacteriaceae	201174|Actinobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS3_k127_2769246_7	1035308.AQYY01000002_gene821	4.655e-06	54.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia	186801|Clostridia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.30	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	M00190,M00193	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11	-	-	ABC_tran,TOBE_2
CMS3_k127_2779971_1	387093.SUN_1594	2.67e-101	335.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,42PA7@68525|delta/epsilon subdivisions,2YNSG@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
CMS3_k127_2779971_9	1121949.AQXT01000002_gene1716	2.177e-07	61.0	COG1983@1|root,COG1983@2|Bacteria	2|Bacteria	KT	positive regulation of macromolecule biosynthetic process	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	DUF2807,DUF4252,PspC,SHOCT
CMS3_k127_2779971_2	1385935.N836_23985	1.595e-86	293.0	COG1794@1|root,COG1794@2|Bacteria,1G62D@1117|Cyanobacteria	1117|Cyanobacteria	M	Belongs to the aspartate glutamate racemases family	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
CMS3_k127_2779971_6	926550.CLDAP_05550	6.215e-44	171.0	COG0679@1|root,COG0679@2|Bacteria,2G7V4@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Auxin Efflux Carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
CMS3_k127_2779971_5	189425.PGRAT_07395	2.056e-48	186.0	COG1482@1|root,COG1482@2|Bacteria,1VRGI@1239|Firmicutes,4HBFW@91061|Bacilli,26QTB@186822|Paenibacillaceae	91061|Bacilli	G	mannose-6-phosphate isomerase	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
CMS3_k127_2779971_0	269796.Rru_A0968	7.452e-106	351.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TREB@28211|Alphaproteobacteria,2JQDG@204441|Rhodospirillales	204441|Rhodospirillales	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
CMS3_k127_2779971_3	518766.Rmar_2376	1.072e-81	287.0	COG3552@1|root,COG3552@2|Bacteria,4NKWF@976|Bacteroidetes	976|Bacteroidetes	S	Protein containing von Willebrand factor type A (vWA) domain	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
CMS3_k127_2779971_7	867903.ThesuDRAFT_01097	1.798e-28	117.0	COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,24AHV@186801|Clostridia	186801|Clostridia	O	XanTHIne and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
CMS3_k127_2779971_4	1382356.JQMP01000004_gene233	1.873e-55	206.0	COG1975@1|root,COG1975@2|Bacteria,2G6H0@200795|Chloroflexi,27XWT@189775|Thermomicrobia	189775|Thermomicrobia	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
CMS3_k127_2779971_8	670487.Ocepr_0101	3.263e-11	76.0	COG2010@1|root,COG2010@2|Bacteria,1WIF2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
CMS3_k127_2831428_0	1313172.YM304_33630	0.0	1085.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1,Thiol-ester_cl
CMS3_k127_2831428_7	1229780.BN381_350053	1.711e-80	273.0	COG4430@1|root,COG4430@2|Bacteria,2H1K0@201174|Actinobacteria	201174|Actinobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
CMS3_k127_2831428_6	644283.Micau_2845	5.675e-88	307.0	COG2242@1|root,COG2242@2|Bacteria,2IAR0@201174|Actinobacteria,4D9FM@85008|Micromonosporales	201174|Actinobacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2831428_11	1122247.C731_0872	7.882e-70	245.0	COG1073@1|root,COG1073@2|Bacteria,2I9HJ@201174|Actinobacteria,237IR@1762|Mycobacteriaceae	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071944,GO:0075136	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
CMS3_k127_2831428_15	1037409.BJ6T_04150	1.277e-24	120.0	COG3119@1|root,COG3119@2|Bacteria,1MYHH@1224|Proteobacteria,2UA67@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS3_k127_2831428_1	765420.OSCT_1890	2.471e-174	564.0	COG1012@1|root,COG1012@2|Bacteria,2G83P@200795|Chloroflexi,3769Y@32061|Chloroflexia	32061|Chloroflexia	C	belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2831428_4	1313172.YM304_07690	6.928e-101	342.0	COG0226@1|root,COG0226@2|Bacteria,2GMY1@201174|Actinobacteria	201174|Actinobacteria	P	phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	HSP70,PBP_like,PBP_like_2
CMS3_k127_2831428_5	1313172.YM304_07700	5.851e-95	321.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria	201174|Actinobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
CMS3_k127_2831428_13	574087.Acear_0864	1.923e-38	161.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,3WA7E@53433|Halanaerobiales	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
CMS3_k127_2831428_3	1463821.JOGR01000016_gene3586	5.744e-110	362.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4EXWB@85014|Glycomycetales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
CMS3_k127_2831428_14	926561.KB900617_gene1488	3.242e-35	144.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,3WANJ@53433|Halanaerobiales	186801|Clostridia	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
CMS3_k127_2831428_9	1304865.JAGF01000001_gene638	2.91e-75	260.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4F0T8@85016|Cellulomonadaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	regX3	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_2831428_8	644282.Deba_1067	7.653e-76	276.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
CMS3_k127_2831428_2	1382306.JNIM01000001_gene3478	5.569e-133	442.0	COG0028@1|root,COG0028@2|Bacteria,2G7NZ@200795|Chloroflexi	200795|Chloroflexi	EH	Belongs to the TPP enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N,adh_short
CMS3_k127_2831428_10	1313172.YM304_24680	5.912e-70	250.0	COG2230@1|root,COG2230@2|Bacteria,2H060@201174|Actinobacteria	201174|Actinobacteria	M	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
CMS3_k127_2831428_12	1380347.JNII01000005_gene3885	2.916e-50	182.0	COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,4ET2T@85013|Frankiales	201174|Actinobacteria	T	low molecular weight	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
CMS3_k127_2857103_4	1254432.SCE1572_14685	1.304e-64	226.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,42PCD@68525|delta/epsilon subdivisions,2WKGQ@28221|Deltaproteobacteria,2YU9M@29|Myxococcales	28221|Deltaproteobacteria	F	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis	pdp	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
CMS3_k127_2857103_9	219305.MCAG_02153	1.537e-12	75.0	COG3695@1|root,COG3695@2|Bacteria,2GQMD@201174|Actinobacteria,4DET5@85008|Micromonosporales	201174|Actinobacteria	L	cysteine	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
CMS3_k127_2857103_1	208444.JNYY01000003_gene1855	1.412e-135	437.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4E0JW@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC transporter	nodI	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
CMS3_k127_2857103_3	1146883.BLASA_1544	3.947e-67	242.0	COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria,4ESWF@85013|Frankiales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
CMS3_k127_2857103_2	211114.JOEF01000001_gene7037	4.046e-99	330.0	COG0842@1|root,COG0842@2|Bacteria,2GMXR@201174|Actinobacteria,4E020@85010|Pseudonocardiales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
CMS3_k127_2857103_8	1449063.JMLS01000023_gene2831	1.553e-25	114.0	COG0500@1|root,COG0500@2|Bacteria,1V4RN@1239|Firmicutes,4HHFD@91061|Bacilli,274IQ@186822|Paenibacillaceae	91061|Bacilli	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS3_k127_2857103_5	945713.IALB_1376	1.445e-60	215.0	COG0035@1|root,COG0035@2|Bacteria	2|Bacteria	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004845,GO:0004849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016763,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	iAF1260.b2498,iAPECO1_1312.APECO1_4071,iB21_1397.B21_02352,iBWG_1329.BWG_2262,iE2348C_1286.E2348C_2723,iEC042_1314.EC042_2699,iEC55989_1330.EC55989_2783,iECABU_c1320.ECABU_c27980,iECBD_1354.ECBD_1190,iECB_1328.ECB_02390,iECDH10B_1368.ECDH10B_2664,iECDH1ME8569_1439.ECDH1ME8569_2424,iECD_1391.ECD_02390,iECED1_1282.ECED1_2921,iECH74115_1262.ECH74115_3720,iECIAI1_1343.ECIAI1_2550,iECIAI39_1322.ECIAI39_2639,iECNA114_1301.ECNA114_2571,iECO103_1326.ECO103_3015,iECO111_1330.ECO111_3222,iECO26_1355.ECO26_3545,iECOK1_1307.ECOK1_2794,iECP_1309.ECP_2500,iECS88_1305.ECS88_2669,iECSE_1348.ECSE_2784,iECSF_1327.ECSF_2339,iECSP_1301.ECSP_3437,iECUMN_1333.ECUMN_2811,iECW_1372.ECW_m2721,iEKO11_1354.EKO11_1236,iETEC_1333.ETEC_2603,iEcDH1_1363.EcDH1_1171,iEcE24377_1341.EcE24377A_2781,iEcHS_1320.EcHS_A2633,iEcSMS35_1347.EcSMS35_2645,iEcolC_1368.EcolC_1178,iG2583_1286.G2583_3021,iJN746.PP_0746,iJO1366.b2498,iJR904.b2498,iLF82_1304.LF82_2383,iNRG857_1313.NRG857_12410,iSFV_1184.SFV_2543,iSF_1195.SF2542,iS_1188.S2691,iSbBS512_1146.SbBS512_E2872,iUMN146_1321.UM146_04235,iUMNK88_1353.UMNK88_3094,iWFL_1372.ECW_m2721,iY75_1357.Y75_RS13040,ic_1306.c3015	UPRTase
CMS3_k127_2857103_0	644966.Tmar_0957	5.092e-153	495.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,3WCDI@538999|Clostridiales incertae sedis	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
CMS3_k127_2857103_7	1229780.BN381_330035	1.321e-28	120.0	COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,3UWU1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
CMS3_k127_2857103_10	292459.STH1467	4.861e-12	68.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia	186801|Clostridia	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
CMS3_k127_2857103_6	446468.Ndas_0226	5.403e-34	136.0	COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,4EJ2M@85012|Streptosporangiales	201174|Actinobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0008150,GO:0040007	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
CMS3_k127_2877375_2	351607.Acel_1756	2.121e-05	55.0	COG1652@1|root,COG1652@2|Bacteria,2GQMU@201174|Actinobacteria,4ETKP@85013|Frankiales	201174|Actinobacteria	S	PFAM Peptidoglycan-binding lysin domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
CMS3_k127_2877375_1	58123.JOFJ01000005_gene1367	3.551e-12	70.0	COG4842@1|root,COG4842@2|Bacteria,2IT9S@201174|Actinobacteria,4EKCJ@85012|Streptosporangiales	201174|Actinobacteria	S	Proteins of 100 residues with WXG	-	-	-	-	-	-	-	-	-	-	-	-	WXG100
CMS3_k127_2877375_0	512565.AMIS_49100	7.943e-126	432.0	COG1674@1|root,COG1716@1|root,COG1674@2|Bacteria,COG1716@2|Bacteria,2GJBR@201174|Actinobacteria	201174|Actinobacteria	D	DNA segregation ATPase FtsK SpoIIIE and related	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FHA,FtsK_SpoIIIE,Yop-YscD_cpl
CMS3_k127_2879141_0	1385520.N802_03220	5.653e-252	809.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4FE2Y@85021|Intrasporangiaceae	201174|Actinobacteria	O	PA domain	sbtB	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Inhibitor_I9,PA,Peptidase_S8
CMS3_k127_2879141_1	478801.Ksed_23290	9.041e-33	131.0	COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria,1ZW3M@145357|Dermacoccaceae	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
CMS3_k127_2881190_12	1408422.JHYF01000001_gene2767	2.908e-42	164.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,36E03@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
CMS3_k127_2881190_16	765420.OSCT_1816	4.545e-24	109.0	COG0816@1|root,COG0816@2|Bacteria,2G74F@200795|Chloroflexi,375V0@32061|Chloroflexia	32061|Chloroflexia	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
CMS3_k127_2881190_10	1121468.AUBR01000003_gene610	1.954e-55	209.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,2493B@186801|Clostridia,42G1M@68295|Thermoanaerobacterales	186801|Clostridia	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
CMS3_k127_2881190_14	1540221.JQNI01000002_gene1011	2.141e-39	163.0	COG0169@1|root,COG0169@2|Bacteria,1WIM8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000166,GO:0003674,GO:0005488,GO:0036094,GO:0048037,GO:0050661,GO:0050662,GO:0097159,GO:1901265,GO:1901363	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
CMS3_k127_2881190_0	1122130.AUHN01000008_gene1588	9.698e-195	622.0	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria	201174|Actinobacteria	NU	type II secretion system protein E	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
CMS3_k127_2881190_2	593907.Celgi_1812	4.629e-124	416.0	COG2805@1|root,COG2805@2|Bacteria,2I9GT@201174|Actinobacteria	201174|Actinobacteria	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS3_k127_2881190_3	1304865.JAGF01000001_gene3208	9.875e-117	389.0	COG1459@1|root,COG1459@2|Bacteria,2GQW0@201174|Actinobacteria	201174|Actinobacteria	NU	type II secretion system	tapC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
CMS3_k127_2881190_19	266117.Rxyl_1158	3.282e-12	73.0	COG4968@1|root,COG4968@2|Bacteria,2I4BD@201174|Actinobacteria,4CU66@84995|Rubrobacteria	84995|Rubrobacteria	NU	Cell motility and secretion Intracellular trafficking and secretion	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS3_k127_2881190_6	312284.A20C1_07538	4.199e-71	248.0	COG1989@1|root,COG1989@2|Bacteria,2HH3X@201174|Actinobacteria,3UXHM@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	NOU	Type IV leader peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	DiS_P_DiS,Peptidase_A24
CMS3_k127_2881190_11	1454010.JEOE01000001_gene617	4.198e-45	177.0	COG4972@1|root,COG4972@2|Bacteria,2IBNF@201174|Actinobacteria	201174|Actinobacteria	NU	pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
CMS3_k127_2881190_18	351607.Acel_1312	3.129e-13	78.0	COG3166@1|root,COG3166@2|Bacteria	2|Bacteria	NU	PFAM Fimbrial assembly family protein	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
CMS3_k127_2881190_20	1217656.F964_00120	1.485e-05	55.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1T05K@1236|Gammaproteobacteria,3NTF3@468|Moraxellaceae	1236|Gammaproteobacteria	NU	Pilus assembly protein, PilO	-	-	-	-	-	-	-	-	-	-	-	-	PilO
CMS3_k127_2881190_1	1246445.ANAY01000007_gene4112	1.227e-135	446.0	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4EIB5@85012|Streptosporangiales	201174|Actinobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2540c	Chorismate_synt
CMS3_k127_2881190_15	633697.EubceDRAFT1_0941	1.496e-27	123.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,24MQY@186801|Clostridia,25WIY@186806|Eubacteriaceae	186801|Clostridia	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,SKI
CMS3_k127_2881190_7	298654.FraEuI1c_1672	4.871e-66	238.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria,4ERXQ@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
CMS3_k127_2881190_9	1121877.JQKF01000024_gene2404	8.078e-65	228.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4CMZZ@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
CMS3_k127_2881190_17	1177594.MIC448_390074	4.26e-20	94.0	COG0781@1|root,COG0781@2|Bacteria,2IM3D@201174|Actinobacteria,4FNSQ@85023|Microbacteriaceae	201174|Actinobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	GO:0008150,GO:0040007	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
CMS3_k127_2881190_8	357808.RoseRS_2864	7.206e-65	227.0	COG2065@1|root,COG2065@2|Bacteria,2G6WS@200795|Chloroflexi,375J4@32061|Chloroflexia	32061|Chloroflexia	F	Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
CMS3_k127_2881190_4	28444.JODQ01000001_gene2211	8.553e-109	361.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4EH29@85012|Streptosporangiales	201174|Actinobacteria	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS3_k127_2881190_5	1313172.YM304_20440	4.355e-100	341.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,4CN0V@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
CMS3_k127_2881190_13	1229780.BN381_50141	3.597e-41	162.0	COG0505@1|root,COG0505@2|Bacteria,2GKFA@201174|Actinobacteria,3UWBX@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1383	CPSase_sm_chain,GATase
CMS3_k127_2928443_2	1313172.YM304_29300	2.459e-08	60.0	COG1595@1|root,COG1595@2|Bacteria,2HB20@201174|Actinobacteria	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
CMS3_k127_2928443_0	43354.JOIJ01000001_gene396	2.818e-34	141.0	COG3147@1|root,COG3147@2|Bacteria,2GYC2@201174|Actinobacteria,4ECZ4@85010|Pseudonocardiales	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2928443_1	298654.FraEuI1c_0288	4.177e-16	84.0	COG1595@1|root,COG1595@2|Bacteria,2GM6A@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_2928857_5	1229204.AMYY01000044_gene2442	1.033e-07	63.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2TT1Y@28211|Alphaproteobacteria,4BQ3W@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	Chain length determinant protein	-	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,GNVR,Wzz
CMS3_k127_2928857_1	266117.Rxyl_2540	1.915e-192	635.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4CPJ8@84995|Rubrobacteria	84995|Rubrobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
CMS3_k127_2928857_2	1232436.CAPF01000016_gene632	1.203e-82	287.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CV1T@84998|Coriobacteriia	84998|Coriobacteriia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS3_k127_2928857_4	1457250.BBMO01000003_gene3219	1.411e-14	78.0	COG0517@1|root,COG2030@1|root,arCOG00606@2157|Archaea,arCOG00778@2157|Archaea,2XVB1@28890|Euryarchaeota,23UQA@183963|Halobacteria	183963|Halobacteria	I	COG0517 FOG CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MaoC_dehydratas
CMS3_k127_2928857_6	351607.Acel_0544	9.73e-06	53.0	2C0MY@1|root,2ZC2Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2928857_0	1313172.YM304_27660	1.575e-245	782.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
CMS3_k127_2928857_3	670487.Ocepr_1916	2.573e-31	132.0	COG1611@1|root,COG1611@2|Bacteria,1WIGV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS3_k127_2930935_6	222534.KB893671_gene3404	5.771e-41	156.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,4ESJ2@85013|Frankiales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K01992,ko:K18233	ko02010,map02010	M00254,M00634	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	3.A.1,3.A.1.105.2	-	-	ABC2_membrane
CMS3_k127_2930935_12	1463825.JNXC01000015_gene7573	2.7e-10	70.0	COG1309@1|root,COG1309@2|Bacteria,2I0Y2@201174|Actinobacteria,4E2PJ@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_2930935_3	1449346.JQMO01000003_gene3002	3.704e-46	171.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,2M26I@2063|Kitasatospora	201174|Actinobacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
CMS3_k127_2930935_7	469381.Dpep_2093	5.352e-38	149.0	COG0634@1|root,COG0634@2|Bacteria,3TB0I@508458|Synergistetes	508458|Synergistetes	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
CMS3_k127_2930935_2	1395587.P364_0130755	2.124e-50	193.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,4HAHH@91061|Bacilli,26T9D@186822|Paenibacillaceae	91061|Bacilli	M	Belongs to the peptidase S11 family	dacB	GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
CMS3_k127_2930935_4	235985.BBPN01000039_gene368	1.405e-45	174.0	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,2NH9A@228398|Streptacidiphilus	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	merR1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
CMS3_k127_2930935_11	1121926.AXWO01000037_gene2615	4.672e-21	98.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4EYJ0@85014|Glycomycetales	201174|Actinobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	garA	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
CMS3_k127_2930935_5	318424.EU78_13950	3.275e-43	161.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,239DN@1762|Mycobacteriaceae	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iNJ661.Rv1826	GCV_H
CMS3_k127_2930935_9	1229780.BN381_40081	1.8e-28	122.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,3UWTG@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS3_k127_2930935_14	1396141.BATP01000004_gene5888	9.166e-07	57.0	2ERYI@1|root,33JHP@2|Bacteria,46WPE@74201|Verrucomicrobia,2IUEZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2930935_13	1172179.AUKV01000002_gene787	7.842e-08	62.0	COG3021@1|root,COG3021@2|Bacteria,2GKXC@201174|Actinobacteria	201174|Actinobacteria	S	endonuclease exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS3_k127_2930935_10	1131730.BAVI_09396	3.704e-27	124.0	COG3594@1|root,COG3594@2|Bacteria	2|Bacteria	G	nodulation	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
CMS3_k127_2930935_8	1122609.AUGT01000015_gene2004	1.936e-33	141.0	COG1376@1|root,COG1376@2|Bacteria,2IIU7@201174|Actinobacteria,4DRAD@85009|Propionibacteriales	201174|Actinobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
CMS3_k127_2930935_1	1123023.JIAI01000020_gene2107	2.032e-127	426.0	COG3383@1|root,COG3383@2|Bacteria,2GKBP@201174|Actinobacteria,4DXFK@85010|Pseudonocardiales	201174|Actinobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,NADH-G_4Fe-4S_3
CMS3_k127_2930935_0	1123023.JIAI01000020_gene2106	7.574e-194	618.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4E076@85010|Pseudonocardiales	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
CMS3_k127_2963425_0	1304888.ATWF01000001_gene573	1.214e-251	816.0	COG0493@1|root,COG0493@2|Bacteria,2GF1T@200930|Deferribacteres	200930|Deferribacteres	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
CMS3_k127_2963425_11	1415166.NONO_c64010	3.577e-08	62.0	2FB55@1|root,343BG@2|Bacteria,2IKSK@201174|Actinobacteria,4G2UT@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2963425_7	383372.Rcas_4372	1.576e-55	207.0	COG4558@1|root,COG4558@2|Bacteria,2GA8E@200795|Chloroflexi,376JD@32061|Chloroflexia	32061|Chloroflexia	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
CMS3_k127_2963425_6	321955.AAGP01000026_gene1613	6.276e-57	211.0	COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria,4FA47@85019|Brevibacteriaceae	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	hmuU	-	-	-	-	-	-	-	-	-	-	-	FecCD
CMS3_k127_2963425_4	1120960.ATXG01000005_gene2401	5.96e-63	226.0	COG4559@1|root,COG4559@2|Bacteria,2GMUI@201174|Actinobacteria,4FNFJ@85023|Microbacteriaceae	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	hmuV	-	1.14.15.20,3.6.3.34	ko:K02013,ko:K21480	ko00860,ko01100,ko01110,ko02010,map00860,map01100,map01110,map02010	M00240	R11579	RC01270	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS3_k127_2963425_8	1002340.AFCF01000031_gene4101	4.406e-51	193.0	COG2114@1|root,COG2114@2|Bacteria,1ND4Q@1224|Proteobacteria,2U51W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Protein of unknown function (DUF2652)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2652,Polyketide_cyc2
CMS3_k127_2963425_9	1192034.CAP_5014	1.969e-37	161.0	COG0642@1|root,COG0784@1|root,COG5000@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,439XQ@68525|delta/epsilon subdivisions,2X1V0@28221|Deltaproteobacteria,2YZ8J@29|Myxococcales	28221|Deltaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_4,Response_reg
CMS3_k127_2963425_1	1121439.dsat_2229	1.304e-225	707.0	COG0031@1|root,COG0031@2|Bacteria,1QQKZ@1224|Proteobacteria,42PVJ@68525|delta/epsilon subdivisions,2WKKY@28221|Deltaproteobacteria,2MEAE@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	PALP
CMS3_k127_2963425_2	1167006.UWK_01323	1.183e-138	452.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WK53@28221|Deltaproteobacteria,2MIJV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_2963425_5	1120983.KB894571_gene2468	9.73e-60	220.0	COG1073@1|root,COG1073@2|Bacteria,1PJHR@1224|Proteobacteria,2U2QB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2963425_3	1410620.SHLA_38c000530	5.794e-114	382.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,4B9XR@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_2963425_12	1122609.AUGT01000005_gene1673	3.622e-07	52.0	COG2114@1|root,COG2114@2|Bacteria,2IQEQ@201174|Actinobacteria,4DV53@85009|Propionibacteriales	201174|Actinobacteria	T	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
CMS3_k127_2963425_10	1298863.AUEP01000001_gene1056	8.88e-10	60.0	COG2114@1|root,COG2114@2|Bacteria,2IQEQ@201174|Actinobacteria	201174|Actinobacteria	T	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
CMS3_k127_2995776_5	765913.ThidrDRAFT_2447	1.64e-24	107.0	COG0569@1|root,COG0569@2|Bacteria,1RIP2@1224|Proteobacteria,1SKEI@1236|Gammaproteobacteria,1X03Z@135613|Chromatiales	135613|Chromatiales	P	TrkA-C domain	-	-	-	-	-	-	-	-	-	-	-	-	TrkA_C
CMS3_k127_2995776_1	1246474.ANBE01000024_gene1685	4.722e-81	276.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4EG4M@85012|Streptosporangiales	201174|Actinobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
CMS3_k127_2995776_6	1235798.C817_05463	6.197e-17	85.0	COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,27VM7@189330|Dorea	186801|Clostridia	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
CMS3_k127_2995776_0	1504822.CCNO01000011_gene231	8.158e-91	322.0	COG2812@1|root,COG2812@2|Bacteria,2NNK7@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_4,DNA_pol3_tau_5,DUF3646
CMS3_k127_2995776_3	1313172.YM304_34870	5.207e-66	231.0	COG5663@1|root,COG5663@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K05967	-	-	-	-	ko00000	-	-	-	NT5C
CMS3_k127_2995776_2	1123065.ATWL01000002_gene1503	5.726e-68	243.0	COG3639@1|root,COG3639@2|Bacteria,2IAPI@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type phosphate phosphonate transport system permease component	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
CMS3_k127_2995776_4	867903.ThesuDRAFT_00782	7.379e-54	198.0	COG3639@1|root,COG3639@2|Bacteria,1TQ73@1239|Firmicutes,24AGQ@186801|Clostridia	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
CMS3_k127_3039757_0	338963.Pcar_2679	1.768e-98	343.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,42MDZ@68525|delta/epsilon subdivisions,2WJ9Y@28221|Deltaproteobacteria,43RZN@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	zinc finger	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
CMS3_k127_3039757_1	1166018.FAES_0742	2.445e-07	63.0	2BW4G@1|root,2ZAQH@2|Bacteria,4NRKB@976|Bacteroidetes,47QKV@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3137
CMS3_k127_3071348_0	926550.CLDAP_18500	9.866e-124	409.0	COG4447@1|root,COG4447@2|Bacteria,2G678@200795|Chloroflexi	200795|Chloroflexi	S	PFAM glycosyl hydrolase BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
CMS3_k127_3071348_6	1214101.BN159_7438	2.828e-80	274.0	2BHEX@1|root,32BGY@2|Bacteria,2GXIC@201174|Actinobacteria	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS3_k127_3071348_8	1038866.KB902846_gene6623	6.022e-57	210.0	COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2TU6T@28211|Alphaproteobacteria,3JX4C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CMS3_k127_3071348_4	1463825.JNXC01000023_gene4894	4.121e-107	356.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4DZ0A@85010|Pseudonocardiales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
CMS3_k127_3071348_5	1206737.BAGF01000151_gene6270	2.107e-100	342.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4FYN0@85025|Nocardiaceae	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
CMS3_k127_3071348_16	290340.AAur_3967	7.156e-08	57.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,1WBK1@1268|Micrococcaceae	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
CMS3_k127_3071348_12	1206733.BAGC01000035_gene3668	1.264e-36	143.0	2BYGD@1|root,32R3C@2|Bacteria,2IPJE@201174|Actinobacteria,4G1Y2@85025|Nocardiaceae	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
CMS3_k127_3071348_1	1297569.MESS2_30073	4.682e-115	386.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2TR5F@28211|Alphaproteobacteria,43I34@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS3_k127_3071348_17	1184609.KILIM_096_00120	8.642e-06	52.0	COG4758@1|root,COG4758@2|Bacteria,2HSTR@201174|Actinobacteria,4F76X@85018|Dermatophilaceae	201174|Actinobacteria	S	Cell wall-active antibiotics response 4TMS YvqF	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
CMS3_k127_3071348_15	391616.OA238_c05670	3.717e-08	64.0	COG0738@1|root,COG0738@2|Bacteria,1QVNU@1224|Proteobacteria,2UMIH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_3071348_11	1036674.A28LD_1047	4.615e-37	142.0	COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1S62I@1236|Gammaproteobacteria,2QGXP@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
CMS3_k127_3071348_13	292459.STH2677	1.356e-25	115.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3071348_9	2002.JOEQ01000028_gene8063	1.624e-55	209.0	COG0477@1|root,COG2814@2|Bacteria,2GMK6@201174|Actinobacteria	201174|Actinobacteria	EGP	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_4
CMS3_k127_3071348_7	1410624.JNKK01000003_gene152	6.236e-60	220.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,24AER@186801|Clostridia,27J3Z@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
CMS3_k127_3071348_3	1453496.AT03_06195	1.095e-107	362.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	O-acetylhomoserine	-	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
CMS3_k127_3071348_10	1121104.AQXH01000001_gene2043	8.025e-49	184.0	COG0500@1|root,COG2226@2|Bacteria,4NJG2@976|Bacteroidetes	976|Bacteroidetes	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_3071348_14	357808.RoseRS_2494	8.517e-13	79.0	COG0517@1|root,COG1993@1|root,COG0517@2|Bacteria,COG1993@2|Bacteria,2G69Z@200795|Chloroflexi,376P4@32061|Chloroflexia	32061|Chloroflexia	T	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF190
CMS3_k127_3074687_3	68170.KL590477_gene2211	5.625e-50	186.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria	201174|Actinobacteria	NU	Type ii secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
CMS3_k127_3074687_4	710696.Intca_2247	4.626e-38	160.0	COG0305@1|root,COG0305@2|Bacteria,2I9NH@201174|Actinobacteria,4FER9@85021|Intrasporangiaceae	201174|Actinobacteria	L	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	DnaB_C
CMS3_k127_3074687_5	465515.Mlut_20860	4.716e-35	144.0	COG1670@1|root,COG1670@2|Bacteria,2IQZ2@201174|Actinobacteria,1W9XP@1268|Micrococcaceae	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
CMS3_k127_3074687_1	1128421.JAGA01000003_gene3673	1.054e-181	585.0	COG4770@1|root,COG4770@2|Bacteria,2NQKT@2323|unclassified Bacteria	2|Bacteria	I	Biotin carboxylase C-terminal domain	bccA	-	6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3285	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
CMS3_k127_3074687_0	266117.Rxyl_2466	4.809e-223	701.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CPHH@84995|Rubrobacteria	84995|Rubrobacteria	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
CMS3_k127_3074687_8	1035308.AQYY01000001_gene3584	2.249e-18	98.0	COG0340@1|root,COG0340@2|Bacteria,1VDES@1239|Firmicutes,24NB4@186801|Clostridia	186801|Clostridia	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
CMS3_k127_3074687_2	1043205.AFYF01000051_gene3051	2.299e-168	548.0	COG0471@1|root,COG0471@2|Bacteria,2HXIC@201174|Actinobacteria,4FH0P@85021|Intrasporangiaceae	201174|Actinobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
CMS3_k127_3074687_6	298654.FraEuI1c_0177	1.541e-32	138.0	COG0489@1|root,COG0489@2|Bacteria	2|Bacteria	D	protein tyrosine kinase activity	-	-	2.7.10.2	ko:K08253	-	-	-	-	ko00000,ko01000	-	-	-	AAA_31,CbiA,ParA,Wzz
CMS3_k127_3075096_0	309801.trd_A0628	0.0	1124.0	COG0243@1|root,COG0243@2|Bacteria,2GABT@200795|Chloroflexi,27Z9X@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS3_k127_3075096_3	469371.Tbis_0410	1.137e-18	93.0	COG0517@1|root,COG0517@2|Bacteria,2I3TG@201174|Actinobacteria,4EC77@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS3_k127_3075096_4	1150399.AQYK01000001_gene1596	4.131e-11	70.0	2E4AX@1|root,32Z6K@2|Bacteria,2I15G@201174|Actinobacteria,4FQ9B@85023|Microbacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF2017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2017
CMS3_k127_3075096_1	1380356.JNIK01000013_gene4051	8.207e-31	126.0	COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,4ESZD@85013|Frankiales	201174|Actinobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
CMS3_k127_3075096_2	1179773.BN6_30630	4.849e-26	111.0	COG1960@1|root,COG1960@2|Bacteria,2GJ4X@201174|Actinobacteria,4DZT0@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA oxidase	acx	-	1.3.3.6	ko:K00232	ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146	M00087,M00113	R01175,R01279,R03777,R03857,R03990,R04751,R04754,R07888,R07892,R07896,R07934,R07950	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	ACOX,Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_3076177_37	1120959.ATXF01000006_gene1724	1.949e-05	54.0	COG4961@1|root,COG4961@2|Bacteria,2IS3K@201174|Actinobacteria,4FQCC@85023|Microbacteriaceae	201174|Actinobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
CMS3_k127_3076177_33	192952.MM_3198	2.138e-18	98.0	COG1073@1|root,arCOG01661@2157|Archaea,2XVIC@28890|Euryarchaeota,2NANZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Alpha/beta hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Peptidase_S9
CMS3_k127_3076177_7	177437.HRM2_43960	2.091e-128	428.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,42N0Z@68525|delta/epsilon subdivisions,2WK80@28221|Deltaproteobacteria,2MMUE@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
CMS3_k127_3076177_8	1148.1653730	8.295e-100	333.0	COG1834@1|root,COG1915@1|root,COG1834@2|Bacteria,COG1915@2|Bacteria,1G2AU@1117|Cyanobacteria,1H595@1142|Synechocystis	1117|Cyanobacteria	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf,Saccharop_dh_N
CMS3_k127_3076177_22	1229780.BN381_150079	3.132e-43	161.0	COG0251@1|root,COG0251@2|Bacteria,2IFCR@201174|Actinobacteria,3UXBZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
CMS3_k127_3076177_29	379066.GAU_2901	1.923e-22	105.0	COG0125@1|root,COG0125@2|Bacteria,1ZUCV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_28
CMS3_k127_3076177_6	1157708.KB907474_gene1148	3.621e-133	446.0	COG3590@1|root,COG3590@2|Bacteria,1QQ5Q@1224|Proteobacteria,2VZP2@28216|Betaproteobacteria	28216|Betaproteobacteria	O	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3076177_21	314265.R2601_15627	1.528e-44	178.0	COG2333@1|root,COG2333@2|Bacteria,1PZYY@1224|Proteobacteria,2UJ6W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3076177_34	1134445.AJJM01000115_gene1899	1.793e-12	72.0	2E6DR@1|root,3311A@2|Bacteria,2IKTW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3076177_2	405948.SACE_3154	6.536e-191	612.0	COG0439@1|root,COG4799@1|root,COG0439@2|Bacteria,COG4799@2|Bacteria,2I2S0@201174|Actinobacteria,4DZ0F@85010|Pseudonocardiales	201174|Actinobacteria	I	Biotin carboxylase C-terminal domain	accA3_1	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
CMS3_k127_3076177_23	1123368.AUIS01000023_gene896	1.106e-38	156.0	COG2267@1|root,COG2267@2|Bacteria,1QYVT@1224|Proteobacteria	1224|Proteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_3076177_17	497321.C664_16200	3.013e-66	239.0	COG1073@1|root,COG1073@2|Bacteria,1MY4C@1224|Proteobacteria,2WEH2@28216|Betaproteobacteria,2KUPJ@206389|Rhodocyclales	206389|Rhodocyclales	S	BAAT Acyl-CoA thioester hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS3_k127_3076177_18	1313172.YM304_12690	2.957e-56	211.0	28ND6@1|root,2ZBG0@2|Bacteria,2H5QC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3076177_30	1095767.CAHD01000235_gene2836	3.735e-22	100.0	2E3QV@1|root,32YNP@2|Bacteria,2GQQZ@201174|Actinobacteria,4F1K6@85016|Cellulomonadaceae	201174|Actinobacteria	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905
CMS3_k127_3076177_20	1229780.BN381_400007	6.295e-51	184.0	COG3576@1|root,COG3576@2|Bacteria,2I6VW@201174|Actinobacteria	201174|Actinobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_3076177_27	1280949.HAD_04020	8.739e-31	124.0	COG1359@1|root,COG1359@2|Bacteria,1N8V7@1224|Proteobacteria,2UFYD@28211|Alphaproteobacteria,43YKB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
CMS3_k127_3076177_19	326426.Bbr_1426	5.609e-51	195.0	COG0524@1|root,COG0524@2|Bacteria,2GMD4@201174|Actinobacteria,4CZW5@85004|Bifidobacteriales	201174|Actinobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
CMS3_k127_3076177_16	1410620.SHLA_46c000310	2.4e-70	245.0	COG0135@1|root,COG0135@2|Bacteria,1RA5Q@1224|Proteobacteria,2U5E8@28211|Alphaproteobacteria,4BIA2@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	-	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
CMS3_k127_3076177_25	1463820.JOGW01000033_gene6592	3.931e-35	145.0	COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria	201174|Actinobacteria	EG	Permeases of the drug metabolite transporter DMT superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_3076177_11	665571.STHERM_c06300	1.558e-89	312.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	ndh	-	1.6.99.3	ko:K03885,ko:K10716	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Abhydrolase_6,Ion_trans,Pyr_redox_2,cNMP_binding
CMS3_k127_3076177_0	1265505.ATUG01000002_gene2452	9.925e-247	784.0	COG2866@1|root,COG2866@2|Bacteria,1N9W9@1224|Proteobacteria,433QQ@68525|delta/epsilon subdivisions,2WY7P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS3_k127_3076177_36	1294265.JCM21738_1839	1.628e-05	58.0	COG2866@1|root,COG2866@2|Bacteria,1TSF6@1239|Firmicutes,4HDT5@91061|Bacilli,1ZBGR@1386|Bacillus	91061|Bacilli	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS3_k127_3076177_5	537013.CLOSTMETH_01994	6.394e-137	455.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247Q9@186801|Clostridia,3WGT9@541000|Ruminococcaceae	186801|Clostridia	S	ABC transporter	yfmR	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
CMS3_k127_3076177_28	1089545.KB913037_gene4317	1.087e-30	124.0	COG3795@1|root,COG3795@2|Bacteria,2IQMR@201174|Actinobacteria,4E69V@85010|Pseudonocardiales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
CMS3_k127_3076177_12	1449976.KALB_8096	2.064e-80	278.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4DXVN@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3076177_35	543632.JOJL01000004_gene4030	4.006e-10	64.0	2B77R@1|root,320A4@2|Bacteria,2IN3T@201174|Actinobacteria,4DE52@85008|Micromonosporales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
CMS3_k127_3076177_10	1121405.dsmv_2999	6.794e-90	313.0	COG1013@1|root,COG1014@1|root,COG1013@2|Bacteria,COG1014@2|Bacteria,1R7US@1224|Proteobacteria,42PFT@68525|delta/epsilon subdivisions,2WMBJ@28221|Deltaproteobacteria,2MJ1Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,TPP_enzyme_C
CMS3_k127_3076177_9	177437.HRM2_38570	5.345e-94	325.0	COG0674@1|root,COG0674@2|Bacteria,1R4K0@1224|Proteobacteria,42NQJ@68525|delta/epsilon subdivisions,2WJ0K@28221|Deltaproteobacteria,2MIND@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
CMS3_k127_3076177_1	526227.Mesil_1001	1.157e-216	689.0	COG1132@1|root,COG1132@2|Bacteria,1WMBB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	COGs COG1132 ABC-type multidrug transport system ATPase and permease components	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
CMS3_k127_3076177_13	2340.JV46_08060	4.738e-73	253.0	COG3369@1|root,COG3369@2|Bacteria,1RE35@1224|Proteobacteria,1T20P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Ferritin-like	-	-	-	-	-	-	-	-	-	-	-	-	Ferritin-like
CMS3_k127_3076177_26	218284.CCDN010000001_gene197	2.044e-33	143.0	COG0598@1|root,COG0598@2|Bacteria,1TPSV@1239|Firmicutes,4HAPC@91061|Bacilli,1ZBVW@1386|Bacillus	91061|Bacilli	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
CMS3_k127_3076177_4	383372.Rcas_1866	5.351e-175	563.0	COG1070@1|root,COG1070@2|Bacteria,2G88R@200795|Chloroflexi	200795|Chloroflexi	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
CMS3_k127_3076177_3	215803.DB30_3757	8.872e-188	599.0	COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,42NQ9@68525|delta/epsilon subdivisions,2WM2K@28221|Deltaproteobacteria,2YUBS@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.2.27	ko:K01634	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00100	R02464,R06516	RC00264,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
CMS3_k127_3076177_31	1123065.ATWL01000007_gene3162	2.097e-20	96.0	COG3576@1|root,COG3576@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
CMS3_k127_3076177_24	1249634.D781_4140	1.136e-35	146.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,402QZ@613|Serratia	1236|Gammaproteobacteria	D	overexpression in Bacillus subtilis inhibits septation in the dividing cell	yhdE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
CMS3_k127_3076177_15	386456.JQKN01000017_gene846	1.031e-72	252.0	COG4832@1|root,arCOG03571@1|root,arCOG03201@2157|Archaea,arCOG03571@2157|Archaea,2Y3NU@28890|Euryarchaeota	28890|Euryarchaeota	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
CMS3_k127_3076177_32	497321.C664_02710	1.716e-19	96.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KUIP@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine Phosphotransfer domain	-	-	2.7.13.1	ko:K05962	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,Response_reg
CMS3_k127_3076177_14	1121272.KB903252_gene934	8.326e-73	249.0	COG0613@1|root,COG0613@2|Bacteria,2GIZ5@201174|Actinobacteria,4D8HD@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3097)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3097
CMS3_k127_3085760_1	1379270.AUXF01000001_gene1916	1.182e-89	302.0	COG1228@1|root,COG1228@2|Bacteria,1ZTI7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_3085760_0	379066.GAU_3367	0.0	1414.0	COG1228@1|root,COG1228@2|Bacteria,1ZTC8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_3129802_0	405948.SACE_7029	5.006e-50	186.0	COG0270@1|root,COG0270@2|Bacteria,2GNB2@201174|Actinobacteria	201174|Actinobacteria	L	DNA (cytosine-5-)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3153360_2	1122223.KB890700_gene2086	5.737e-48	177.0	COG2010@1|root,COG2010@2|Bacteria,1WMT3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
CMS3_k127_3153360_0	926569.ANT_04560	2.81e-71	254.0	COG0796@1|root,COG0796@2|Bacteria,2G8GN@200795|Chloroflexi	200795|Chloroflexi	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
CMS3_k127_3153360_5	357276.EL88_17825	0.0003157	46.0	2A371@1|root,30RNK@2|Bacteria,4PDX5@976|Bacteroidetes,2FRCD@200643|Bacteroidia,4AP3M@815|Bacteroidaceae	976|Bacteroidetes	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
CMS3_k127_3153360_4	525909.Afer_1274	2.191e-07	61.0	COG3745@1|root,COG3745@2|Bacteria,2HH0M@201174|Actinobacteria,4CP0W@84992|Acidimicrobiia	84992|Acidimicrobiia	U	SAF	-	-	-	-	-	-	-	-	-	-	-	-	SAF
CMS3_k127_3153360_3	1121017.AUFG01000016_gene2562	5.923e-24	115.0	COG0455@1|root,COG0455@2|Bacteria,2IARP@201174|Actinobacteria,4FFKI@85021|Intrasporangiaceae	201174|Actinobacteria	D	CobQ/CobB/MinD/ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
CMS3_k127_3153360_1	273677.BW34_00598	3.3e-58	218.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4FKCP@85023|Microbacteriaceae	201174|Actinobacteria	U	Type II/IV secretion system protein	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
CMS3_k127_3172969_12	222534.KB893683_gene1167	1.412e-93	316.0	COG0463@1|root,COG0463@2|Bacteria,2I568@201174|Actinobacteria,4ESA2@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_3172969_34	1120936.KB907208_gene648	8.816e-17	91.0	COG0392@1|root,COG0392@2|Bacteria,2IC25@201174|Actinobacteria,4EJ4G@85012|Streptosporangiales	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027,ko:K20468	-	-	-	-	ko00000,ko02000	4.D.2,4.D.2.4.1	-	-	LPG_synthase_TM
CMS3_k127_3172969_20	1120936.KB907208_gene647	6.648e-59	218.0	COG0438@1|root,COG0438@2|Bacteria,2GX8V@201174|Actinobacteria,4EG9S@85012|Streptosporangiales	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_3172969_10	414684.RC1_3780	6.69e-112	369.0	COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,2TS7U@28211|Alphaproteobacteria,2JQTR@204441|Rhodospirillales	204441|Rhodospirillales	JM	Nucleotidyl transferase	rfbF	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
CMS3_k127_3172969_9	1041142.ATTP01000037_gene4081	2.488e-115	383.0	COG0451@1|root,COG0451@2|Bacteria,1MV73@1224|Proteobacteria,2TU81@28211|Alphaproteobacteria,4B8DF@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	CDP-glucose 4,6-dehydratase	rfbG	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS3_k127_3172969_5	395493.BegalDRAFT_2267	1.743e-147	482.0	COG2227@1|root,COG2227@2|Bacteria,1QU62@1224|Proteobacteria,1T2QC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Putative zinc binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
CMS3_k127_3172969_17	1528106.JRJE01000002_gene1928	9.896e-63	220.0	COG1898@1|root,COG1898@2|Bacteria,1RDAB@1224|Proteobacteria,2U99D@28211|Alphaproteobacteria,2JSSZ@204441|Rhodospirillales	204441|Rhodospirillales	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
CMS3_k127_3172969_18	1282361.ABAC402_09565	1.052e-61	227.0	COG0451@1|root,COG0451@2|Bacteria,1RBIE@1224|Proteobacteria,2U7JV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	Nad-dependent epimerase dehydratase	-	-	1.1.1.339	ko:K19180	ko00523,ko01130,map00523,map01130	-	R10190	RC00182	ko00000,ko00001,ko01000	-	-	-	Epimerase
CMS3_k127_3172969_14	1221522.B723_07600	3.556e-82	280.0	COG3510@1|root,COG3510@2|Bacteria,1MWJ8@1224|Proteobacteria,1RY5R@1236|Gammaproteobacteria,1YNZF@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	V	Cephalosporin hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	CmcI
CMS3_k127_3172969_30	640081.Dsui_0066	9.456e-29	131.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_3172969_0	1120948.KB903243_gene2400	2.627e-222	712.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4E2BB@85010|Pseudonocardiales	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	cutL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS3_k127_3172969_32	1379698.RBG1_1C00001G0327	3.588e-25	120.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
CMS3_k127_3172969_13	639030.JHVA01000001_gene779	1.072e-84	301.0	COG1007@1|root,COG1007@2|Bacteria,3Y3PV@57723|Acidobacteria,2JIT3@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
CMS3_k127_3172969_4	237368.SCABRO_01998	1.411e-157	516.0	COG1008@1|root,COG1008@2|Bacteria,2IX79@203682|Planctomycetes	203682|Planctomycetes	C	proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
CMS3_k127_3172969_2	247490.KSU1_D0317	1.221e-176	573.0	COG1009@1|root,COG1009@2|Bacteria,2IX10@203682|Planctomycetes	203682|Planctomycetes	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
CMS3_k127_3172969_31	1121877.JQKF01000009_gene573	3.022e-26	113.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria,4CN4N@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
CMS3_k127_3172969_33	216594.MMAR_1474	3.29e-24	112.0	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,233A9@1762|Mycobacteriaceae	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
CMS3_k127_3172969_15	525909.Afer_0371	6.03e-76	260.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4CMPP@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
CMS3_k127_3172969_11	525909.Afer_0370	5.704e-104	349.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4CMTV@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
CMS3_k127_3172969_1	1229780.BN381_160007	1.619e-189	620.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,3UWBF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	nuoG	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
CMS3_k127_3172969_6	1379698.RBG1_1C00001G1055	2.124e-144	472.0	COG1894@1|root,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
CMS3_k127_3172969_24	710685.MycrhN_0249	4.626e-36	144.0	COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,2332U@1762|Mycobacteriaceae	201174|Actinobacteria	C	NADH dehydrogenase	nuoE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS3_k127_3172969_3	525909.Afer_0366	1.981e-162	524.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4CMP9@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
CMS3_k127_3172969_25	1313172.YM304_04080	2.615e-34	139.0	COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria,4CN4G@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
CMS3_k127_3172969_16	298653.Franean1_6093	5.877e-69	244.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,4ERM4@85013|Frankiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
CMS3_k127_3172969_29	267608.RSc2062	4.7e-30	123.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2VSI3@28216|Betaproteobacteria,1K7MQ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
CMS3_k127_3172969_7	1229780.BN381_450016	9.961e-143	465.0	COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,3UX9K@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	FAD binding domain	menJ	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016491,GO:0016627,GO:0030312,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
CMS3_k127_3172969_27	1122602.ATXP01000009_gene566	1.297e-32	142.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	MA20_27720	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_3172969_35	1229780.BN381_450015	2.855e-13	80.0	COG2010@1|root,COG2010@2|Bacteria,2H5KX@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3172969_26	1008457.BAEX01000055_gene631	8.148e-34	150.0	COG2993@1|root,COG3278@1|root,COG2993@2|Bacteria,COG3278@2|Bacteria,4NEGM@976|Bacteroidetes,1HWQ5@117743|Flavobacteriia,47H8Z@76831|Myroides	976|Bacteroidetes	C	Cytochrome C and Quinol oxidase polypeptide I	ccoN	-	1.9.3.1	ko:K15862	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1,FixO
CMS3_k127_3172969_36	1229780.BN381_450013	3.348e-08	62.0	2C3UQ@1|root,341WW@2|Bacteria,2H6NT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3172969_22	1229780.BN381_450012	6.52e-41	158.0	COG1143@1|root,COG1143@2|Bacteria,2H4NQ@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10
CMS3_k127_3172969_8	1313172.YM304_04010	3.444e-128	414.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4CN9T@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cytochrome b/b6/petB	-	-	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
CMS3_k127_3172969_19	1313172.YM304_04020	2.49e-61	227.0	COG1290@1|root,COG1290@2|Bacteria,2H1Y8@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
CMS3_k127_3172969_23	1229780.BN381_450009	5.095e-38	153.0	COG0723@1|root,COG0723@2|Bacteria,2H0R5@201174|Actinobacteria	201174|Actinobacteria	C	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
CMS3_k127_3172969_28	1229780.BN381_450008	1.232e-30	138.0	COG2010@1|root,COG2010@2|Bacteria,2H49G@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
CMS3_k127_3172969_21	1089545.KB913037_gene5009	8.787e-43	160.0	COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria,4DY6U@85010|Pseudonocardiales	201174|Actinobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
CMS3_k127_3174930_10	439235.Dalk_2897	2.923e-05	55.0	COG5184@1|root,COG5276@1|root,COG5184@2|Bacteria,COG5276@2|Bacteria,1R504@1224|Proteobacteria,42QHC@68525|delta/epsilon subdivisions,2WKUI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	DZ	Alpha-tubulin suppressor and related RCC1 domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	RCC1,RCC1_2
CMS3_k127_3174930_0	1123242.JH636435_gene1911	2.257e-178	581.0	COG0210@1|root,COG0210@2|Bacteria,2IY8S@203682|Planctomycetes	203682|Planctomycetes	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
CMS3_k127_3174930_11	452863.Achl_0582	0.0004055	49.0	COG1280@1|root,COG1280@2|Bacteria,2GMDP@201174|Actinobacteria	201174|Actinobacteria	E	Lysine exporter protein (LysE YggA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
CMS3_k127_3174930_6	1313172.YM304_20220	1.356e-38	151.0	2DMMI@1|root,32SFN@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3151)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3151
CMS3_k127_3174930_4	1211815.CBYP010000020_gene1826	9.25e-68	237.0	COG1024@1|root,COG1024@2|Bacteria,2I9VC@201174|Actinobacteria,4EUX4@85013|Frankiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_3174930_8	596328.HMPREF0578_1360	5.803e-30	123.0	COG0071@1|root,COG0071@2|Bacteria,2IHVJ@201174|Actinobacteria,4D5HW@85005|Actinomycetales	201174|Actinobacteria	O	Belongs to the small heat shock protein (HSP20) family	hsp18	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS3_k127_3174930_7	313628.LNTAR_04476	5.707e-33	138.0	COG0496@1|root,COG0496@2|Bacteria	2|Bacteria	P	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.1,3.1.3.5,3.1.3.8	ko:K01083,ko:K01113,ko:K03787	ko00230,ko00240,ko00562,ko00760,ko00790,ko01100,ko01110,ko02020,map00230,map00240,map00562,map00760,map00790,map01100,map01110,map02020	M00126	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R03371,R04620	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iSFxv_1172.SFxv_3035	SurE
CMS3_k127_3174930_3	1123237.Salmuc_03667	3.52e-81	278.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,2U391@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	xylanase chitin deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
CMS3_k127_3174930_1	331869.BAL199_18541	6.75e-113	373.0	COG1834@1|root,COG1834@2|Bacteria,1R7NG@1224|Proteobacteria,2U4ZK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
CMS3_k127_3174930_9	1071085.KK033114_gene1317	1.256e-12	74.0	COG0071@1|root,arCOG01832@2157|Archaea,2XYW4@28890|Euryarchaeota,23X30@183963|Halobacteria	183963|Halobacteria	O	Belongs to the small heat shock protein (HSP20) family	hsp20a	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS3_k127_3174930_5	1313172.YM304_05050	2.254e-40	153.0	COG0454@1|root,COG0456@2|Bacteria,2IMVD@201174|Actinobacteria,4CNB7@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_3174930_2	1254432.SCE1572_08670	6.807e-91	315.0	COG4826@1|root,COG4826@2|Bacteria,1REGX@1224|Proteobacteria,42T9N@68525|delta/epsilon subdivisions,2WPDB@28221|Deltaproteobacteria,2YV97@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
CMS3_k127_319080_0	1288494.EBAPG3_12100	3.544e-195	630.0	COG2303@1|root,COG2303@2|Bacteria,1MXUT@1224|Proteobacteria,2VJBD@28216|Betaproteobacteria,372I3@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DAO,DUF1080,FAD_binding_2,GMC_oxred_C
CMS3_k127_3201986_4	366602.Caul_0436	2.15e-07	61.0	COG0477@1|root,COG2814@2|Bacteria,1NAK9@1224|Proteobacteria,2UHZU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	MFS_1
CMS3_k127_3201986_0	649638.Trad_2970	5.794e-106	366.0	COG0534@1|root,COG0534@2|Bacteria,1WMCE@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	COGs COG0534 Na -driven multidrug efflux pump	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
CMS3_k127_3201986_1	665577.JH993790_gene1868	1.22e-61	221.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
CMS3_k127_3201986_2	765420.OSCT_2244	5.508e-40	156.0	COG0503@1|root,COG0503@2|Bacteria,2G71F@200795|Chloroflexi	200795|Chloroflexi	F	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis	xpt	-	2.4.2.22	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
CMS3_k127_3201986_3	309801.trd_1308	1.723e-20	96.0	COG2050@1|root,COG2050@2|Bacteria,2G751@200795|Chloroflexi,27Z8E@189775|Thermomicrobia	189775|Thermomicrobia	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS3_k127_325455_2	502025.Hoch_1947	4.501e-24	113.0	COG2885@1|root,COG2885@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	1224|Proteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	1.B.6	-	-	Cadherin_3,DUF11,DUF4347,OmpA,Phenol_MetA_deg,TSP_3
CMS3_k127_325455_1	452863.Achl_2111	1.987e-26	115.0	COG1917@1|root,COG1917@2|Bacteria,2IFSF@201174|Actinobacteria	201174|Actinobacteria	IQ	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_325455_0	102129.Lepto7375DRAFT_5059	7.359e-120	399.0	COG0028@1|root,COG2146@1|root,COG0028@2|Bacteria,COG2146@2|Bacteria,1G4R6@1117|Cyanobacteria,1HAC6@1150|Oscillatoriales	1117|Cyanobacteria	H	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_3318714_4	222984.JNCS01000010_gene17	8.531e-07	61.0	arCOG02980@1|root,arCOG02980@2157|Archaea,2XTKT@28890|Euryarchaeota,23SJA@183963|Halobacteria	183963|Halobacteria	S	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3318714_1	512565.AMIS_75170	3.299e-66	237.0	COG0313@1|root,COG0313@2|Bacteria,2GJ9Q@201174|Actinobacteria,4DA84@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
CMS3_k127_3318714_3	697281.Mahau_2211	9.071e-18	86.0	COG2002@1|root,COG2002@2|Bacteria,1VA3H@1239|Firmicutes,24MN7@186801|Clostridia,42GY0@68295|Thermoanaerobacterales	186801|Clostridia	K	TIGRFAM transcriptional regulator, AbrB family	abrB	-	-	ko:K06284	-	-	-	-	ko00000,ko03000	-	-	-	MazE_antitoxin
CMS3_k127_3318714_0	298653.Franean1_5898	3.018e-220	696.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4ES23@85013|Frankiales	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
CMS3_k127_3318714_2	745277.GRAQ_04444	8.162e-27	114.0	COG0084@1|root,COG0084@2|Bacteria,1MXN8@1224|Proteobacteria,1RNCC@1236|Gammaproteobacteria,3FFQK@34037|Rahnella	1236|Gammaproteobacteria	L	3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair	tatD	GO:0000175,GO:0000302,GO:0000738,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009056,GO:0009057,GO:0009636,GO:0009987,GO:0010035,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046700,GO:0046872,GO:0050896,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901700	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
CMS3_k127_3349126_0	760192.Halhy_4904	1.165e-45	168.0	COG1741@1|root,COG1741@2|Bacteria,4NFZD@976|Bacteroidetes	976|Bacteroidetes	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
CMS3_k127_3352944_10	103733.JNYO01000003_gene8351	5.451e-26	115.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4DYBT@85010|Pseudonocardiales	201174|Actinobacteria	L	Tyrosine recombinase XerD	xerD	GO:0008150,GO:0040007	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS3_k127_3352944_17	1089546.AQUI01000002_gene1586	0.0007783	46.0	COG0454@1|root,COG0456@2|Bacteria,2IFM6@201174|Actinobacteria	201174|Actinobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Condensation
CMS3_k127_3352944_13	412597.AEPN01000014_gene2340	1.232e-06	60.0	COG0697@1|root,COG0697@2|Bacteria,1R4G2@1224|Proteobacteria,2TTS7@28211|Alphaproteobacteria,2PUXJ@265|Paracoccus	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_3352944_3	471875.RUMLAC_02466	1.189e-50	197.0	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,3WIM4@541000|Ruminococcaceae	186801|Clostridia	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
CMS3_k127_3352944_1	262724.TT_C1785	1.067e-127	424.0	COG0606@1|root,COG0606@2|Bacteria,1WI18@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	ATPase with chaperone activity	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
CMS3_k127_3352944_11	1229780.BN381_330044	2.193e-15	82.0	2E3EP@1|root,31HCP@2|Bacteria,2HM0W@201174|Actinobacteria,3UX08@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3352944_14	1121020.JIAG01000010_gene257	6.026e-05	50.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,1WA4Z@1268|Micrococcaceae	201174|Actinobacteria	L	Belongs to the UPF0102 family	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
CMS3_k127_3352944_8	649831.L083_6865	2.817e-40	151.0	2AFXT@1|root,3161G@2|Bacteria,2IKPZ@201174|Actinobacteria,4DDG2@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2469)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2469
CMS3_k127_3352944_4	253839.SSNG_05159	7.413e-50	185.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria	201174|Actinobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
CMS3_k127_3352944_5	649831.L083_2395	1.441e-49	184.0	COG0122@1|root,COG0122@2|Bacteria,2IPPK@201174|Actinobacteria	201174|Actinobacteria	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
CMS3_k127_3352944_7	356851.JOAN01000003_gene1672	1.742e-45	173.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4DBDV@85008|Micromonosporales	201174|Actinobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
CMS3_k127_3352944_6	477641.MODMU_4415	3.295e-46	169.0	COG0335@1|root,COG0335@2|Bacteria,2IHRT@201174|Actinobacteria,4ESVQ@85013|Frankiales	201174|Actinobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
CMS3_k127_3352944_2	1417296.U879_07795	4.326e-68	241.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2TSIZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
CMS3_k127_3352944_16	471855.Shel_14850	0.0004279	51.0	COG0393@1|root,COG0393@2|Bacteria,2IQNY@201174|Actinobacteria,4CW21@84998|Coriobacteriia	84998|Coriobacteriia	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
CMS3_k127_3352944_9	710685.MycrhN_2818	9.978e-40	157.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DUF3703,PAP2
CMS3_k127_3352944_15	575540.Isop_3283	0.0001966	52.0	COG0642@1|root,COG0784@1|root,COG3292@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,2IXFD@203682|Planctomycetes	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	rcsC	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009268,GO:0009628,GO:0009927,GO:0009987,GO:0010447,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042710,GO:0043170,GO:0043412,GO:0044010,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051716,GO:0060089,GO:0065007,GO:0071214,GO:0071470,GO:0071704,GO:0071944,GO:0104004,GO:0140096,GO:1901564	2.7.13.3	ko:K07677,ko:K07679	ko02020,ko02026,ko05133,map02020,map02026,map05133	M00474,M00477	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,RcsC,Response_reg,SBP_bac_3
CMS3_k127_3352944_12	138119.DSY3073	5.505e-11	70.0	COG1309@1|root,COG1309@2|Bacteria,1VDU2@1239|Firmicutes,24Q7T@186801|Clostridia,264AT@186807|Peptococcaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_3352944_0	266117.Rxyl_0975	3.528e-141	457.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4CPHP@84995|Rubrobacteria	84995|Rubrobacteria	H	Elongator protein 3 MiaB NifB	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
CMS3_k127_3402922_2	1460634.JCM19037_3596	6.113e-30	131.0	COG5276@1|root,COG5276@2|Bacteria,1UUVN@1239|Firmicutes,4HBJX@91061|Bacilli	91061|Bacilli	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
CMS3_k127_3402922_0	644966.Tmar_0901	1.093e-243	782.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,3WD0A@538999|Clostridiales incertae sedis	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
CMS3_k127_3402922_1	1382356.JQMP01000003_gene2493	2.962e-44	180.0	COG1595@1|root,COG1595@2|Bacteria,2GBDV@200795|Chloroflexi,27Z17@189775|Thermomicrobia	189775|Thermomicrobia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
CMS3_k127_3402922_3	1123508.JH636445_gene6576	5.281e-10	72.0	COG2931@1|root,COG3209@1|root,COG2931@2|Bacteria,COG3209@2|Bacteria,2IYH3@203682|Planctomycetes	203682|Planctomycetes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
CMS3_k127_3411635_1	446466.Cfla_3661	1.483e-55	199.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
CMS3_k127_3411635_5	521096.Tpau_4284	1.204e-06	51.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
CMS3_k127_3411635_6	1416759.AYMR01000001_gene1454	5.736e-05	46.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4FMJD@85023|Microbacteriaceae	201174|Actinobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
CMS3_k127_3411635_2	1449355.JQNR01000005_gene4851	9.703e-47	172.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
CMS3_k127_3411635_4	234267.Acid_5713	1.479e-14	78.0	COG1520@1|root,COG1520@2|Bacteria,3Y74A@57723|Acidobacteria	57723|Acidobacteria	S	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	PQQ_2
CMS3_k127_3411635_3	525909.Afer_1452	2.764e-29	122.0	COG1959@1|root,COG1959@2|Bacteria,2GS0E@201174|Actinobacteria,4CNRF@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS3_k127_3411635_7	1121877.JQKF01000033_gene2001	0.000695	46.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria	201174|Actinobacteria	L	Transposase IS116 IS110 IS902	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS3_k127_3421416_14	1122609.AUGT01000004_gene1364	0.0002535	46.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4DPR9@85009|Propionibacteriales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_3421416_12	1120973.AQXL01000130_gene1299	3.837e-15	87.0	COG1277@1|root,COG1277@2|Bacteria,1V2H6@1239|Firmicutes,4HC35@91061|Bacilli,2797C@186823|Alicyclobacillaceae	91061|Bacilli	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
CMS3_k127_3421416_1	326427.Cagg_0207	1.45e-109	366.0	COG0714@1|root,COG0714@2|Bacteria,2GACN@200795|Chloroflexi,375BZ@32061|Chloroflexia	32061|Chloroflexia	S	PFAM ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_3421416_7	1303518.CCALI_00370	2.103e-48	184.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_3421416_9	1128421.JAGA01000003_gene3247	1.09e-42	177.0	COG2304@1|root,COG2304@2|Bacteria,2NQHG@2323|unclassified Bacteria	2|Bacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
CMS3_k127_3421416_0	1128421.JAGA01000003_gene3234	1.583e-112	403.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,2NQSS@2323|unclassified Bacteria	2|Bacteria	S	Putative glutamine amidotransferase	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,GATase1_like,VWA,VWA_2,VWA_3
CMS3_k127_3421416_10	356851.JOAN01000007_gene4036	1.102e-23	106.0	COG5496@1|root,COG5496@2|Bacteria,2IKZP@201174|Actinobacteria,4DE8F@85008|Micromonosporales	201174|Actinobacteria	S	Thioesterase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS3_k127_3421416_13	429009.Adeg_0923	3.124e-06	57.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24BK7@186801|Clostridia,42JBW@68295|Thermoanaerobacterales	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CMS3_k127_3421416_11	483219.LILAB_24040	2.096e-18	97.0	COG0526@1|root,COG0526@2|Bacteria,1N726@1224|Proteobacteria,42U61@68525|delta/epsilon subdivisions,2WQRF@28221|Deltaproteobacteria,2YVYE@29|Myxococcales	28221|Deltaproteobacteria	CO	Redoxin	dsbE	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
CMS3_k127_3421416_5	562970.Btus_2167	2.351e-51	190.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1UYNA@1239|Firmicutes,4HA9R@91061|Bacilli,279NY@186823|Alicyclobacillaceae	91061|Bacilli	E	Histidine biosynthesis bifunctional protein HisIE	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS14110,iYO844.BSU34860	PRA-CH,PRA-PH
CMS3_k127_3421416_2	1280950.HJO_11482	1.876e-92	316.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2TQXD@28211|Alphaproteobacteria,43WDK@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CMS3_k127_3421416_6	1442599.JAAN01000024_gene1922	1.176e-48	183.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,1X5IB@135614|Xanthomonadales	135614|Xanthomonadales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
CMS3_k127_3421416_4	940282.CADQ01000031_gene1961	8.037e-63	221.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2TTVV@28211|Alphaproteobacteria,2JPDI@204441|Rhodospirillales	204441|Rhodospirillales	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
CMS3_k127_3421416_8	1304880.JAGB01000001_gene290	1.479e-44	175.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_3421416_3	525904.Tter_0659	3.475e-92	313.0	COG0141@1|root,COG0141@2|Bacteria,2NNTS@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,1.1.1.308	ko:K00013,ko:K15509	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
CMS3_k127_3423476_2	395963.Bind_0035	4.202e-31	124.0	COG5470@1|root,COG5470@2|Bacteria,1MWI7@1224|Proteobacteria,2U0S6@28211|Alphaproteobacteria,3NCGV@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
CMS3_k127_3423476_3	395963.Bind_0035	1.984e-05	53.0	COG5470@1|root,COG5470@2|Bacteria,1MWI7@1224|Proteobacteria,2U0S6@28211|Alphaproteobacteria,3NCGV@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
CMS3_k127_3423476_0	471852.Tcur_2882	2.38e-165	541.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EGNQ@85012|Streptosporangiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K02021,ko:K06147,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_membrane,ABC_tran
CMS3_k127_3423476_1	526225.Gobs_3228	2.091e-44	165.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EUMQ@85013|Frankiales	201174|Actinobacteria	V	ABC transporter, transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
CMS3_k127_342394_1	1380347.JNII01000009_gene2309	3.849e-96	327.0	COG1404@1|root,COG1404@2|Bacteria,2IAS7@201174|Actinobacteria,4ERYY@85013|Frankiales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS3_k127_342394_5	345341.KUTG_01617	2.102e-45	174.0	COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria,4E3XB@85010|Pseudonocardiales	201174|Actinobacteria	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
CMS3_k127_342394_10	1416759.AYMR01000041_gene1925	8.172e-05	47.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_342394_4	926560.KE387025_gene4044	5.812e-68	244.0	2C1EG@1|root,2Z7MZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_342394_8	760192.Halhy_2094	2.561e-12	75.0	2C1EG@1|root,2Z7MZ@2|Bacteria,4NYQE@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_342394_6	1298867.AUES01000005_gene217	3.112e-24	105.0	COG3631@1|root,COG3631@2|Bacteria,1RI43@1224|Proteobacteria,2UAI9@28211|Alphaproteobacteria,3JZCQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Ketosteroid isomerase-related protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_342394_0	930169.B5T_00549	1.555e-258	818.0	28IUR@1|root,2Z8TE@2|Bacteria,1NW7C@1224|Proteobacteria,1RP4W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_342394_9	1313172.YM304_22460	5.365e-08	56.0	COG0484@1|root,COG0484@2|Bacteria,2HAB8@201174|Actinobacteria,4CP1J@84992|Acidimicrobiia	84992|Acidimicrobiia	O	DnaJ molecular chaperone homology domain	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ
CMS3_k127_342394_2	1869.MB27_02930	2.657e-83	287.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4D9AV@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	tcsR3	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_342394_3	479435.Kfla_1238	5.569e-72	258.0	COG1983@1|root,COG4585@1|root,COG1983@2|Bacteria,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4DNII@85009|Propionibacteriales	201174|Actinobacteria	T	PspC domain	tcsS3	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,PspC
CMS3_k127_3439517_0	649638.Trad_1259	2.383e-196	619.0	COG0045@1|root,COG0045@2|Bacteria,1WIT1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
CMS3_k127_3439517_3	649638.Trad_1258	3.565e-149	477.0	COG0074@1|root,COG0074@2|Bacteria,1WJBR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
CMS3_k127_3439517_11	926550.CLDAP_01990	1.534e-46	174.0	COG1280@1|root,COG1280@2|Bacteria,2G702@200795|Chloroflexi	200795|Chloroflexi	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
CMS3_k127_3439517_9	287986.DV20_14535	1.359e-57	212.0	arCOG08211@1|root,2ZBM3@2|Bacteria,2IDNP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3439517_10	1380346.JNIH01000003_gene2144	5.866e-55	204.0	COG0299@1|root,COG0299@2|Bacteria,2H8QB@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
CMS3_k127_3439517_4	401526.TcarDRAFT_0399	1.075e-144	476.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H34D@909932|Negativicutes	909932|Negativicutes	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
CMS3_k127_3439517_8	690850.Desaf_0472	2.523e-88	300.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2WJ90@28221|Deltaproteobacteria,2M9FA@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
CMS3_k127_3439517_1	525909.Afer_1881	5.106e-181	573.0	COG0538@1|root,COG0538@2|Bacteria,2IBM8@201174|Actinobacteria,4CNHG@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CMS3_k127_3439517_6	222534.KB893748_gene2766	1.446e-125	409.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria,4ESBM@85013|Frankiales	201174|Actinobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
CMS3_k127_3439517_5	469383.Cwoe_4099	1.351e-128	421.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_3439517_2	469383.Cwoe_4100	1.138e-172	556.0	COG0044@1|root,COG0044@2|Bacteria,2GKEC@201174|Actinobacteria,4CRXW@84995|Rubrobacteria	84995|Rubrobacteria	F	PFAM amidohydrolase	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
CMS3_k127_3439517_7	1120960.ATXG01000005_gene2524	4.112e-109	362.0	COG1073@1|root,COG1073@2|Bacteria,2GNB6@201174|Actinobacteria,4FQUP@85023|Microbacteriaceae	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
CMS3_k127_3439517_12	1122201.AUAZ01000002_gene945	5.355e-26	109.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria,467ZY@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS3_k127_3439517_13	1122137.AQXF01000001_gene2798	2.639e-05	50.0	COG3255@1|root,COG3255@2|Bacteria,1N0RD@1224|Proteobacteria,2UBXK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
CMS3_k127_3445369_5	326427.Cagg_1682	2.11e-19	92.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	MA20_23570	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_34
CMS3_k127_3445369_0	1033802.SSPSH_000964	6.798e-130	428.0	COG2271@1|root,COG2271@2|Bacteria,1QXP5@1224|Proteobacteria,1T4EF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_3445369_6	1313172.YM304_32920	9.79e-05	51.0	COG3324@1|root,COG3324@2|Bacteria,2I6WX@201174|Actinobacteria	201174|Actinobacteria	E	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3445369_3	1183377.Py04_0265	4.667e-24	113.0	COG5623@1|root,arCOG04127@2157|Archaea,2XT4Z@28890|Euryarchaeota,243KY@183968|Thermococci	183968|Thermococci	A	Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of both single-stranded RNA (ssRNA) and single- stranded DNA (ssDNA). Exhibits a strong preference for ssRNA	-	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019205,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0051731,GO:0071704,GO:0090304,GO:1901360	-	ko:K06947	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	CLP1_P
CMS3_k127_3445369_2	485913.Krac_2372	7.875e-67	237.0	2DBVK@1|root,2ZBBH@2|Bacteria,2G7SF@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3445369_4	1227739.Hsw_0299	1.428e-20	95.0	2DBVK@1|root,2ZBBH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3445369_1	195250.CM001776_gene2980	2.132e-109	360.0	COG0365@1|root,COG0365@2|Bacteria,1G0E7@1117|Cyanobacteria,1GZ2X@1129|Synechococcus	1117|Cyanobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
CMS3_k127_346918_8	42256.RradSPS_1289	1.033e-54	199.0	COG0003@1|root,COG0003@2|Bacteria,2GISZ@201174|Actinobacteria,4CPDY@84995|Rubrobacteria	84995|Rubrobacteria	P	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
CMS3_k127_346918_6	106370.Francci3_3092	2.076e-61	226.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,4ERT7@85013|Frankiales	201174|Actinobacteria	GK	PFAM ROK family protein	glkA	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0051156,GO:0071704,GO:1901135	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
CMS3_k127_346918_14	335541.Swol_1633	4.192e-15	84.0	COG3339@1|root,COG3339@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
CMS3_k127_346918_0	880072.Desac_2029	1.825e-153	496.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2MQW6@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	yfdZ	-	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_346918_7	1123226.KB899277_gene1253	1.857e-57	211.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4HBCU@91061|Bacilli,26QJX@186822|Paenibacillaceae	91061|Bacilli	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
CMS3_k127_346918_3	1448139.AI20_14100	7.056e-110	365.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1Y51Z@135624|Aeromonadales	135624|Aeromonadales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS3_k127_346918_5	525903.Taci_1097	5.716e-81	277.0	COG1028@1|root,COG1028@2|Bacteria,3TAAZ@508458|Synergistetes	508458|Synergistetes	IQ	TIGRFAM 3-oxoacyl-(acyl-carrier-protein) reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_346918_13	1121403.AUCV01000002_gene514	1.726e-16	82.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,42V9M@68525|delta/epsilon subdivisions,2WRDW@28221|Deltaproteobacteria,2MKUS@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CMS3_k127_346918_1	485916.Dtox_1182	1.146e-152	493.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,2602N@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS3_k127_346918_11	710111.FraQA3DRAFT_3959	3.048e-22	104.0	COG0406@1|root,COG0406@2|Bacteria,2GMXF@201174|Actinobacteria,4ESMJ@85013|Frankiales	201174|Actinobacteria	G	phosphoglycerate mutase	-	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	His_Phos_1
CMS3_k127_346918_4	1150864.MILUP08_45145	5.736e-86	299.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4D8ZI@85008|Micromonosporales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
CMS3_k127_346918_17	1121877.JQKF01000004_gene1087	1.446e-08	60.0	2ERJT@1|root,33J59@2|Bacteria,2HGGQ@201174|Actinobacteria,4CNDW@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3040
CMS3_k127_346918_12	479433.Caci_3131	1.207e-21	102.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
CMS3_k127_346918_9	1048339.KB913029_gene4588	9.822e-43	181.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria,4ERJY@85013|Frankiales	201174|Actinobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
CMS3_k127_346918_10	710111.FraQA3DRAFT_2868	1.744e-32	141.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4ERVY@85013|Frankiales	201174|Actinobacteria	J	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_346918_2	390989.JOEG01000008_gene1350	6.424e-115	379.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4D9JV@85008|Micromonosporales	201174|Actinobacteria	S	ATPase associated with various cellular activities	yeaC	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_346918_18	861299.J421_2311	1.645e-07	59.0	2FKCY@1|root,34C0C@2|Bacteria,1ZU3I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_346918_19	1353537.TP2_04140	0.0005751	51.0	COG1961@1|root,COG1961@2|Bacteria,1MV0C@1224|Proteobacteria,2TTJT@28211|Alphaproteobacteria,2XKGI@285107|Thioclava	28211|Alphaproteobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
CMS3_k127_346918_15	1313421.JHBV01000019_gene5357	1.519e-13	77.0	COG1595@1|root,COG1595@2|Bacteria,4NU6U@976|Bacteroidetes,1J0AR@117747|Sphingobacteriia	976|Bacteroidetes	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_346918_16	219305.MCAG_03422	6.422e-09	61.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4D9V4@85008|Micromonosporales	201174|Actinobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS3_k127_3479065_10	1313421.JHBV01000020_gene5292	2.05e-22	112.0	COG1409@1|root,COG1409@2|Bacteria,4NGK2@976|Bacteroidetes,1IWCK@117747|Sphingobacteriia	976|Bacteroidetes	S	Purple acid Phosphatase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
CMS3_k127_3479065_7	35754.JNYJ01000002_gene6869	1.895e-35	153.0	COG1874@1|root,COG4733@1|root,COG1874@2|Bacteria,COG4733@2|Bacteria,2GNR4@201174|Actinobacteria,4D9D5@85008|Micromonosporales	201174|Actinobacteria	G	Domain of unknown function (DUF4832)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4832
CMS3_k127_3479065_15	1336243.JAEA01000001_gene1892	1.632e-08	67.0	COG2374@1|root,COG2931@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,1JSIH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Calx-beta,Exo_endo_phos,HemolysinCabind,Peptidase_M10_C
CMS3_k127_3479065_11	471852.Tcur_0793	3.6e-21	96.0	2CUM0@1|root,32SVJ@2|Bacteria,2IQG7@201174|Actinobacteria,4EK6A@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF3263)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3263
CMS3_k127_3479065_4	406124.ACPC01000048_gene216	7.181e-38	160.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,4H9SR@91061|Bacilli,1ZCDX@1386|Bacillus	91061|Bacilli	S	transporter activity	yueF	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CMS3_k127_3479065_18	880073.Calab_2749	0.000589	51.0	COG1286@1|root,COG1286@2|Bacteria,2NQ58@2323|unclassified Bacteria	2|Bacteria	S	Colicin V production protein	cvpA	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
CMS3_k127_3479065_19	866895.HBHAL_5030	0.0008945	50.0	2EAZJ@1|root,3350E@2|Bacteria,1VGFD@1239|Firmicutes,4HNX8@91061|Bacilli,3NEZQ@45667|Halobacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3153
CMS3_k127_3479065_6	1229780.BN381_680006	4.377e-36	149.0	COG0697@1|root,COG0697@2|Bacteria,2GU83@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_3479065_0	710111.FraQA3DRAFT_3341	1.964e-175	579.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_3479065_2	568703.LGG_00033	4.559e-60	221.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,4HB8D@91061|Bacilli,3F3YU@33958|Lactobacillaceae	91061|Bacilli	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_3479065_9	316274.Haur_4580	1.826e-22	103.0	COG1510@1|root,COG1510@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
CMS3_k127_3479065_16	350054.Mflv_0699	6.333e-07	59.0	2B15X@1|root,31TJX@2|Bacteria,2GSJS@201174|Actinobacteria,23BBM@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510
CMS3_k127_3479065_14	471857.Svir_26810	5.63e-09	60.0	COG2356@1|root,COG2356@2|Bacteria,2GJ38@201174|Actinobacteria,4EB2A@85010|Pseudonocardiales	201174|Actinobacteria	L	Protein of unknown function (DUF1524)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1524
CMS3_k127_3479065_12	331869.BAL199_17483	1.766e-10	65.0	COG2356@1|root,COG2356@2|Bacteria,1RI3H@1224|Proteobacteria,2U9E4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Protein of unknown function (DUF1524)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1524
CMS3_k127_3479065_3	1370120.AUWR01000035_gene1874	1.196e-39	164.0	COG0584@1|root,COG0584@2|Bacteria,2GIY5@201174|Actinobacteria,233QN@1762|Mycobacteriaceae	201174|Actinobacteria	C	Glycerophosphoryl diester phosphodiesterase family	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS3_k127_3479065_8	2002.JOEQ01000017_gene7855	1.621e-22	108.0	COG2334@1|root,COG2334@2|Bacteria,2GIYP@201174|Actinobacteria	201174|Actinobacteria	M	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS3_k127_3479065_1	926550.CLDAP_35110	6.166e-135	439.0	COG0205@1|root,COG0205@2|Bacteria,2G6CJ@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
CMS3_k127_3479065_5	1306174.JODP01000011_gene6700	4.119e-37	146.0	COG1595@1|root,COG1595@2|Bacteria,2GTC7@201174|Actinobacteria	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3479065_17	935866.JAER01000003_gene1293	1.77e-05	56.0	COG4932@1|root,COG4932@2|Bacteria,2I2ZN@201174|Actinobacteria	201174|Actinobacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
CMS3_k127_3479065_13	1122604.JONR01000002_gene1627	2.608e-10	68.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,1S5YV@1236|Gammaproteobacteria,1X5ZB@135614|Xanthomonadales	135614|Xanthomonadales	CO	Thiol disulfide interchange protein	ccmG1	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
CMS3_k127_3479206_0	1379698.RBG1_1C00001G1211	4.092e-108	358.0	COG0034@1|root,COG0034@2|Bacteria,2NNSY@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iSB619.SA_RS05225	GATase_6,GATase_7,Pribosyltran
CMS3_k127_3536489_1	1120949.KB903322_gene2809	1.843e-94	312.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,4DCG6@85008|Micromonosporales	201174|Actinobacteria	E	Choline dehydrogenase and related flavoproteins	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
CMS3_k127_3536489_4	1123065.ATWL01000002_gene1481	8.913e-09	62.0	2E6D0@1|root,3310N@2|Bacteria,2GQP8@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3054)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3054
CMS3_k127_3536489_2	285514.JNWO01000002_gene5488	5.897e-55	218.0	COG3507@1|root,COG4733@1|root,COG3507@2|Bacteria,COG4733@2|Bacteria,2GK1U@201174|Actinobacteria	201174|Actinobacteria	E	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,F5_F8_type_C,RicinB_lectin_2
CMS3_k127_3536489_0	1313172.YM304_32480	4.939e-145	469.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4CMW3@84992|Acidimicrobiia	84992|Acidimicrobiia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran
CMS3_k127_3536489_3	926554.KI912680_gene858	4.119e-18	87.0	COG0662@1|root,COG0662@2|Bacteria,1WMY9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_3555254_16	608538.HTH_1885	4.899e-15	86.0	COG2210@1|root,COG2210@2|Bacteria,2G565@200783|Aquificae	200783|Aquificae	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
CMS3_k127_3555254_17	932678.THERU_00150	8.132e-15	77.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE,TusA
CMS3_k127_3555254_4	1125863.JAFN01000001_gene198	1.117e-112	373.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42M6M@68525|delta/epsilon subdivisions,2WIQM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EJ	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	cysM	-	2.5.1.47,6.1.1.16	ko:K01738,ko:K01883,ko:K12339	ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00359,M00360	R00897,R03132,R03601,R03650,R04859	RC00020,RC00055,RC00523,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,PALP,tRNA-synt_1e
CMS3_k127_3555254_1	1297569.MESS2_300088	7.821e-193	608.0	COG0604@1|root,COG0604@2|Bacteria,1MXIK@1224|Proteobacteria,2TQPR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	ccrA	-	1.1.1.1,1.3.1.85	ko:K00001,ko:K14446	ko00010,ko00071,ko00350,ko00625,ko00626,ko00630,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00071,map00350,map00625,map00626,map00630,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220	M00373	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R09291	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC02481	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_3555254_20	272942.RCAP_rcc00590	7.441e-09	63.0	COG3703@1|root,COG3703@2|Bacteria,1N0A5@1224|Proteobacteria,2UDPP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	AIG2-like family	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2
CMS3_k127_3555254_5	314345.SPV1_05467	3.282e-106	364.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria	1224|Proteobacteria	Q	COG1233 Phytoene dehydrogenase and related proteins	-	-	1.3.99.23,5.2.1.13	ko:K09516,ko:K09835	ko00830,ko00906,ko01100,ko01110,map00830,map00906,map01100,map01110	M00097	R07163,R07512	RC01835,RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
CMS3_k127_3555254_9	290315.Clim_1925	1.718e-59	217.0	COG4995@1|root,COG4995@2|Bacteria,1FEVM@1090|Chlorobi	1090|Chlorobi	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
CMS3_k127_3555254_0	555088.DealDRAFT_2538	1.442e-260	816.0	COG1960@1|root,COG1960@2|Bacteria,1V03D@1239|Firmicutes,24A8N@186801|Clostridia	186801|Clostridia	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
CMS3_k127_3555254_18	749414.SBI_05562	8.738e-12	73.0	2EBG5@1|root,335GQ@2|Bacteria,2GRUT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3555254_19	945713.IALB_2166	1.129e-11	73.0	COG2820@1|root,COG2820@2|Bacteria	2|Bacteria	F	uridine phosphorylase activity	amn	-	2.4.2.3,3.2.2.4	ko:K00757,ko:K01241	ko00230,ko00240,ko00983,ko01100,map00230,map00240,map00983,map01100	-	R00182,R01876,R02484,R08229	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
CMS3_k127_3555254_2	471852.Tcur_3392	5.522e-166	534.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria,4EFKQ@85012|Streptosporangiales	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
CMS3_k127_3555254_15	1382306.JNIM01000001_gene2489	2.409e-23	108.0	2C5C8@1|root,345UA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3555254_13	356851.JOAN01000001_gene3909	6.654e-42	160.0	COG1522@1|root,COG1522@2|Bacteria,2GP1P@201174|Actinobacteria,4DBHK@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
CMS3_k127_3555254_3	1122239.AULS01000001_gene1850	2.521e-147	481.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4FM80@85023|Microbacteriaceae	201174|Actinobacteria	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_3555254_8	1469245.JFBG01000072_gene70	1.328e-60	215.0	COG1853@1|root,COG1853@2|Bacteria,1MUPP@1224|Proteobacteria,1RR4T@1236|Gammaproteobacteria,1WYXT@135613|Chromatiales	135613|Chromatiales	S	PFAM flavin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
CMS3_k127_3555254_12	649747.HMPREF0083_06230	3.958e-43	167.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1UYB2@1239|Firmicutes,4HIMD@91061|Bacilli,26TDP@186822|Paenibacillaceae	91061|Bacilli	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
CMS3_k127_3555254_21	395495.Lcho_0047	0.0004414	48.0	COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1N58A@1224|Proteobacteria,2VHVP@28216|Betaproteobacteria,1KN51@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	yfhK	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_3555254_7	1313172.YM304_27160	3.583e-65	238.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria	201174|Actinobacteria	CP	ABC-type Na efflux pump, permease	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
CMS3_k127_3555254_6	1313172.YM304_27150	4.846e-92	312.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS3_k127_3555254_10	1031288.AXAA01000010_gene419	4.17e-58	228.0	COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,2491Y@186801|Clostridia,36ERD@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.1.3.6,3.1.4.16	ko:K01081,ko:K01119	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos,SH3_3,SLH
CMS3_k127_356780_4	285514.JNWO01000017_gene7478	1.998e-09	61.0	COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,2GJ4Y@201174|Actinobacteria	201174|Actinobacteria	L	helicase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3427,Helicase_C,PLDc_2,ResIII
CMS3_k127_356780_2	981384.AEYW01000014_gene141	2.259e-55	208.0	COG2114@1|root,COG2114@2|Bacteria,1NC69@1224|Proteobacteria,2VFPU@28211|Alphaproteobacteria,4NDPS@97050|Ruegeria	1224|Proteobacteria	T	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,SnoaL_3
CMS3_k127_356780_1	717606.PaecuDRAFT_1144	3.001e-60	222.0	2DBMF@1|root,2Z9YG@2|Bacteria,1VYCA@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_356780_0	1255043.TVNIR_1740	1.384e-96	325.0	COG0457@1|root,COG0457@2|Bacteria,1R1XZ@1224|Proteobacteria	1224|Proteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4071
CMS3_k127_3571361_4	1089549.AZUQ01000001_gene2442	3.86e-56	202.0	COG1922@1|root,COG1922@2|Bacteria,2ICDG@201174|Actinobacteria,4EYRY@85014|Glycomycetales	201174|Actinobacteria	M	Glycosyl transferase WecB/TagA/CpsF family	rffM	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
CMS3_k127_3571361_0	309798.COPRO5265_1333	1.115e-87	299.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,42F5I@68295|Thermoanaerobacterales	186801|Clostridia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS3_k127_3571361_2	1242864.D187_005375	4.747e-70	246.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria,2YXQ1@29|Myxococcales	28221|Deltaproteobacteria	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
CMS3_k127_3571361_3	316055.RPE_3491	7.372e-69	261.0	COG3420@1|root,COG3420@2|Bacteria,1NNDG@1224|Proteobacteria,2UNM9@28211|Alphaproteobacteria,3K2HK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS3_k127_3571361_1	926554.KI912677_gene2502	1.936e-80	282.0	COG0438@1|root,COG0438@2|Bacteria,1WJ3P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_3571361_5	426355.Mrad2831_3343	7.102e-08	63.0	COG3307@1|root,COG3307@2|Bacteria,1N0EK@1224|Proteobacteria,2UCUX@28211|Alphaproteobacteria,1JU6P@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	O-Antigen ligase	exoQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K16567	-	-	-	-	ko00000	-	-	-	Wzy_C
CMS3_k127_3575173_2	1223523.H340_24285	2.402e-77	269.0	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria	201174|Actinobacteria	E	LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
CMS3_k127_3575173_4	562970.Btus_1081	3.306e-14	78.0	COG0694@1|root,COG0694@2|Bacteria,1VAAU@1239|Firmicutes,4HKQ8@91061|Bacilli,278KT@186823|Alicyclobacillaceae	91061|Bacilli	O	NifU-like domain	yutI	-	-	-	-	-	-	-	-	-	-	-	NifU
CMS3_k127_3575173_3	584708.Apau_1433	1.314e-35	151.0	COG2385@1|root,COG2385@2|Bacteria,3T9PB@508458|Synergistetes	508458|Synergistetes	D	SpoIID LytB domain protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
CMS3_k127_3575173_1	351607.Acel_0657	6.806e-130	427.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4ERJ6@85013|Frankiales	201174|Actinobacteria	M	Belongs to the EPSP synthase family. MurA subfamily	murA	GO:0008150,GO:0040007	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
CMS3_k127_3575173_0	1380347.JNII01000007_gene699	2.939e-207	663.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,4ERTG@85013|Frankiales	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
CMS3_k127_3582710_10	1283283.ATXA01000019_gene2945	5.886e-13	72.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
CMS3_k127_3582710_8	1410624.JNKK01000048_gene1383	2.869e-20	100.0	COG2340@1|root,COG2931@1|root,COG3209@1|root,COG5184@1|root,COG5263@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG5184@2|Bacteria,COG5263@2|Bacteria,1UPJN@1239|Firmicutes,25HIC@186801|Clostridia,27Q8S@186928|unclassified Lachnospiraceae	186801|Clostridia	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3582710_4	446462.Amir_3391	2.461e-42	161.0	COG1670@1|root,COG1670@2|Bacteria,2HJTN@201174|Actinobacteria,4E73N@85010|Pseudonocardiales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
CMS3_k127_3582710_9	1122182.KB903813_gene2441	1.445e-15	81.0	COG4634@1|root,COG4634@2|Bacteria,2GWC9@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3582710_7	526225.Gobs_3728	3.094e-27	117.0	2E73E@1|root,331MX@2|Bacteria,2IRHV@201174|Actinobacteria,4EVZR@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
CMS3_k127_3582710_5	1229780.BN381_130142	1.547e-39	151.0	COG2337@1|root,COG2337@2|Bacteria,2IR5D@201174|Actinobacteria	201174|Actinobacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
CMS3_k127_3582710_3	1240349.ANGC01000009_gene2805	2.101e-50	190.0	COG3832@1|root,COG3832@2|Bacteria,2GY9A@201174|Actinobacteria,4G0ZK@85025|Nocardiaceae	201174|Actinobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3582710_0	429009.Adeg_0010	4.029e-131	436.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia,42EYX@68295|Thermoanaerobacterales	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase catalytic region	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
CMS3_k127_3582710_6	1000565.METUNv1_01440	1.405e-33	142.0	COG0560@1|root,COG0560@2|Bacteria	2|Bacteria	E	Phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD,Hydrolase
CMS3_k127_3582710_12	1048339.KB913029_gene788	5.501e-12	77.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,PAP2
CMS3_k127_3582710_1	28072.Nos7524_1364	8.057e-98	335.0	COG0477@1|root,COG0477@2|Bacteria,1GHCR@1117|Cyanobacteria,1HKQS@1161|Nostocales	1117|Cyanobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
CMS3_k127_3582710_11	222534.KB893670_gene3715	6.293e-13	76.0	COG1846@1|root,COG1846@2|Bacteria,2IJHQ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator (MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
CMS3_k127_3582710_2	28444.JODQ01000009_gene3637	1.007e-82	312.0	COG2319@1|root,COG3629@1|root,COG2319@2|Bacteria,COG3629@2|Bacteria,2GJN3@201174|Actinobacteria,4EMXK@85012|Streptosporangiales	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,HTH_31,Trans_reg_C,WD40
CMS3_k127_3613937_11	1459636.NTE_01663	1.2e-16	94.0	COG2237@1|root,COG3794@1|root,arCOG02926@2157|Archaea,arCOG02929@2157|Archaea,arCOG04151@2157|Archaea,41SHN@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
CMS3_k127_3613937_8	1229909.NSED_07010	4.051e-25	122.0	COG3794@1|root,arCOG10350@1|root,arCOG02926@2157|Archaea,arCOG10350@2157|Archaea	2157|Archaea	C	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Kazal_1
CMS3_k127_3613937_13	1041522.MCOL_V216469	7.734e-15	89.0	COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria,23AQX@1762|Mycobacteriaceae	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
CMS3_k127_3613937_3	479432.Sros_4744	4.403e-47	176.0	COG2197@1|root,COG2197@2|Bacteria,2H2NU@201174|Actinobacteria,4EM9W@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_3613937_5	869210.Marky_0355	7.908e-33	147.0	COG4585@1|root,COG4585@2|Bacteria,1WJNH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA_3,PAS,PAS_4,PAS_8
CMS3_k127_3613937_7	765420.OSCT_1793	1.467e-27	124.0	COG0526@1|root,COG0526@2|Bacteria,2GACV@200795|Chloroflexi,375FU@32061|Chloroflexia	32061|Chloroflexia	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
CMS3_k127_3613937_2	1205680.CAKO01000040_gene788	9.502e-64	232.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JP9V@204441|Rhodospirillales	28211|Alphaproteobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
CMS3_k127_3613937_1	1068980.ARVW01000001_gene6741	1.231e-127	420.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4DZPY@85010|Pseudonocardiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
CMS3_k127_3613937_0	498761.HM1_0975	1.754e-135	446.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia	186801|Clostridia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
CMS3_k127_3613937_6	1229780.BN381_100140	5.384e-29	124.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,3UWRZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
CMS3_k127_3613937_9	211114.JOEF01000003_gene2768	2.344e-18	87.0	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4E5E1@85010|Pseudonocardiales	201174|Actinobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
CMS3_k127_3613937_4	1121877.JQKF01000007_gene976	1.649e-43	163.0	COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,4CN4R@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Single-strand binding protein family	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
CMS3_k127_3613937_10	1229780.BN381_100143	4.869e-17	88.0	COG0360@1|root,COG0360@2|Bacteria,2IQHD@201174|Actinobacteria,3UWQU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
CMS3_k127_3613937_12	1111069.TCCBUS3UF1_5630	2.178e-16	87.0	COG1430@1|root,COG1430@2|Bacteria,1WJRZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
CMS3_k127_3716055_1	981384.AEYW01000023_gene3838	5.678e-81	275.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,4NCYD@97050|Ruegeria	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
CMS3_k127_3716055_0	45351.EDO48725	8.305e-91	307.0	COG0620@1|root,KOG2263@2759|Eukaryota,38GZS@33154|Opisthokonta,3BNKS@33208|Metazoa	33208|Metazoa	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
CMS3_k127_3736164_4	525909.Afer_1585	6.605e-104	361.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4CMUW@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS3_k127_3736164_1	1120983.KB894571_gene2483	1.98e-154	493.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS3_k127_3736164_6	1123023.JIAI01000001_gene7771	7.436e-87	299.0	COG1071@1|root,COG1071@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	-	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K11381,ko:K21416	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
CMS3_k127_3736164_0	543632.JOJL01000020_gene629	7.987e-176	560.0	COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
CMS3_k127_3736164_3	1380394.JADL01000002_gene1393	7.211e-105	351.0	COG2084@1|root,COG2084@2|Bacteria,1P0X0@1224|Proteobacteria,2U2X9@28211|Alphaproteobacteria,2JTJW@204441|Rhodospirillales	204441|Rhodospirillales	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
CMS3_k127_3736164_15	796606.BMMGA3_16535	5.823e-29	122.0	COG1765@1|root,COG1765@2|Bacteria,1V7SR@1239|Firmicutes,4HK3E@91061|Bacilli,1ZR2H@1386|Bacillus	91061|Bacilli	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
CMS3_k127_3736164_13	351607.Acel_0891	1.403e-48	182.0	COG2128@1|root,COG2128@2|Bacteria,2HTUG@201174|Actinobacteria,4EUKU@85013|Frankiales	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3736164_18	216595.PFLU_2767	4.082e-15	88.0	COG0477@1|root,COG2814@2|Bacteria,1QUAS@1224|Proteobacteria,1RPFC@1236|Gammaproteobacteria,1YQR7@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	EGP	Transporter	stp_1	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
CMS3_k127_3736164_5	1449353.JQMQ01000004_gene5930	3.66e-87	299.0	COG1609@1|root,COG1609@2|Bacteria,2GNVD@201174|Actinobacteria,2NJ4S@228398|Streptacidiphilus	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS3_k127_3736164_14	196162.Noca_4459	4.393e-34	142.0	COG2128@1|root,COG2128@2|Bacteria,2HZX3@201174|Actinobacteria,4DUDY@85009|Propionibacteriales	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3736164_7	1242864.D187_003344	6.346e-73	258.0	COG1064@1|root,COG1064@2|Bacteria,1RAY7@1224|Proteobacteria	1224|Proteobacteria	S	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_3736164_2	397278.JOJN01000002_gene614	3.061e-149	481.0	COG5276@1|root,COG5276@2|Bacteria,2IH2N@201174|Actinobacteria	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
CMS3_k127_3736164_8	1038858.AXBA01000021_gene4758	1.856e-67	241.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3F1EG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
CMS3_k127_3736164_11	1220534.B655_0836	7.343e-50	184.0	COG4430@1|root,arCOG10241@2157|Archaea,2XUJA@28890|Euryarchaeota,23PV8@183925|Methanobacteria	183925|Methanobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
CMS3_k127_3736164_19	1313172.YM304_03670	2.942e-10	68.0	COG1388@1|root,COG1595@1|root,COG1388@2|Bacteria,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02656,ko:K03088,ko:K14196	ko05150,map05150	-	-	-	ko00000,ko00001,ko02035,ko02044,ko03021	-	-	-	LysM,SPOR,TPR_12,TPR_17,TPR_2,TPR_8,Whib
CMS3_k127_3736164_20	443143.GM18_3141	1.998e-09	61.0	2DQBG@1|root,335T7@2|Bacteria,1R35T@1224|Proteobacteria,42ZVK@68525|delta/epsilon subdivisions,2WV6B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	1.21.4.1	ko:K10794	ko00330,map00330	-	R02825	RC00790	ko00000,ko00001,ko01000	-	-	-	GRDB
CMS3_k127_3736164_16	324602.Caur_0049	8.923e-23	105.0	2DQBG@1|root,335T7@2|Bacteria,2G8Y8@200795|Chloroflexi,377IB@32061|Chloroflexia	32061|Chloroflexia	S	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	-	-	-	-	-	-	-	-	-	-	GRDB
CMS3_k127_3736164_17	679926.Mpet_1615	7.297e-22	109.0	COG0596@1|root,arCOG01657@2157|Archaea,2XXEE@28890|Euryarchaeota	28890|Euryarchaeota	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,DUF1100
CMS3_k127_3736164_9	36809.MAB_4797	1.615e-62	229.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,234RA@1762|Mycobacteriaceae	201174|Actinobacteria	C	F420-dependent oxidoreductase, Rv1855c family	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_3736164_12	43354.JOIJ01000012_gene937	2.368e-49	185.0	COG0479@1|root,COG0479@2|Bacteria,2GP9C@201174|Actinobacteria,4DXT9@85010|Pseudonocardiales	201174|Actinobacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	frdB	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1553	Fer2_3,Fer4_8
CMS3_k127_3736164_10	43354.JOIJ01000012_gene936	3.161e-50	184.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4DZPA@85010|Pseudonocardiales	201174|Actinobacteria	C	succinate dehydrogenase	sdhA	-	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CMS3_k127_3737099_3	652103.Rpdx1_0631	3.145e-53	196.0	COG4106@1|root,COG4106@2|Bacteria,1QWJU@1224|Proteobacteria,2TWZZ@28211|Alphaproteobacteria,3K6QN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_3737099_2	1122611.KB903969_gene2392	5.823e-109	370.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4EHEC@85012|Streptosporangiales	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
CMS3_k127_3737099_1	882083.SacmaDRAFT_2583	3.041e-131	438.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4EBQT@85010|Pseudonocardiales	201174|Actinobacteria	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
CMS3_k127_3737099_5	350058.Mvan_4028	1.907e-16	83.0	COG0607@1|root,COG0607@2|Bacteria,2HS2C@201174|Actinobacteria,23A8E@1762|Mycobacteriaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CMS3_k127_3737099_0	710696.Intca_2820	1.822e-148	486.0	COG0437@1|root,COG3301@1|root,COG0437@2|Bacteria,COG3301@2|Bacteria,2I2DV@201174|Actinobacteria,4FF0K@85021|Intrasporangiaceae	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_3,Fer4_4,Fer4_7,NrfD
CMS3_k127_3737099_4	1122176.KB903565_gene3328	1.158e-38	151.0	COG0243@1|root,COG0243@2|Bacteria,4NITD@976|Bacteroidetes	976|Bacteroidetes	C	Molybdopterin oxidoreductase	-	-	1.7.2.3,1.8.5.5	ko:K07812,ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.4,5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS3_k127_3754196_0	298655.KI912266_gene5297	8.75e-74	252.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4ERX9@85013|Frankiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS3_k127_3754196_1	446466.Cfla_0194	2.127e-24	112.0	COG1595@1|root,COG1595@2|Bacteria,2IRNG@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3754196_2	411902.CLOBOL_04982	1.107e-05	58.0	COG0526@1|root,COG0526@2|Bacteria,1V7JP@1239|Firmicutes,25ET7@186801|Clostridia,21XXE@1506553|Lachnoclostridium	186801|Clostridia	CO	Redoxin	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,Redoxin
CMS3_k127_3760087_11	1463853.JOHW01000017_gene5286	1.973e-30	123.0	COG1917@1|root,COG1917@2|Bacteria,2IHSV@201174|Actinobacteria	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_3760087_7	1206733.BAGC01000107_gene6551	1.146e-63	227.0	COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria,4FWXB@85025|Nocardiaceae	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
CMS3_k127_3760087_3	1121272.KB903290_gene4659	1.904e-89	305.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4D8QU@85008|Micromonosporales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS3_k127_3760087_8	1255043.TVNIR_1014	7.047e-54	204.0	COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,1RRKZ@1236|Gammaproteobacteria,1WWQA@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
CMS3_k127_3760087_9	1380386.JIAW01000004_gene345	7.411e-48	181.0	COG3541@1|root,COG3541@2|Bacteria,2GUQV@201174|Actinobacteria,238C4@1762|Mycobacteriaceae	201174|Actinobacteria	S	Predicted nucleotidyltransferase	-	-	-	ko:K07074	-	-	-	-	ko00000	-	-	-	Nuc-transf
CMS3_k127_3760087_18	1499967.BAYZ01000048_gene2701	3.484e-07	56.0	2DMDR@1|root,32QSY@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1475)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1475
CMS3_k127_3760087_5	1463821.JOGR01000001_gene1395	6.567e-67	236.0	COG3361@1|root,COG3361@2|Bacteria,2I6N0@201174|Actinobacteria,4EZIP@85014|Glycomycetales	201174|Actinobacteria	S	Uncharacterized conserved protein (COG2071)	wcoQ	-	-	ko:K09166	-	-	-	-	ko00000	-	-	-	DUF2071
CMS3_k127_3760087_0	1380394.JADL01000013_gene582	2.427e-125	410.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2TUI2@28211|Alphaproteobacteria,2JSEI@204441|Rhodospirillales	204441|Rhodospirillales	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
CMS3_k127_3760087_16	404380.Gbem_3041	3.274e-17	89.0	COG3157@1|root,COG3157@2|Bacteria,1RBTU@1224|Proteobacteria,42XEQ@68525|delta/epsilon subdivisions,2WTD9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Type VI secretion system effector, Hcp	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
CMS3_k127_3760087_15	1122599.AUGR01000010_gene1097	1.542e-17	89.0	COG1226@1|root,COG1226@2|Bacteria,1R97G@1224|Proteobacteria,1RQAR@1236|Gammaproteobacteria,1XS1M@135619|Oceanospirillales	135619|Oceanospirillales	P	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	-
CMS3_k127_3760087_1	526225.Gobs_2629	7.831e-102	349.0	COG1807@1|root,COG1807@2|Bacteria,2GK3Q@201174|Actinobacteria,4EU3N@85013|Frankiales	201174|Actinobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_3760087_4	1283299.AUKG01000003_gene675	1.206e-72	253.0	COG1028@1|root,COG1028@2|Bacteria,2GKW9@201174|Actinobacteria,4CRZW@84995|Rubrobacteria	84995|Rubrobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_3760087_17	1051632.TPY_2991	9.193e-09	62.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia	186801|Clostridia	H	PFAM Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_3760087_6	1336243.JAEA01000002_gene2692	5.4e-65	232.0	COG2114@1|root,COG2114@2|Bacteria,1N6I7@1224|Proteobacteria,2U3M0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4242,Guanylate_cyc
CMS3_k127_3760087_14	1500897.JQNA01000001_gene6879	1.536e-17	91.0	COG3157@1|root,COG3157@2|Bacteria,1R651@1224|Proteobacteria,2VRTT@28216|Betaproteobacteria,1K79V@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Type VI secretion system effector, Hcp	-	-	-	ko:K06887,ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
CMS3_k127_3760087_2	1120934.KB894429_gene1664	4.301e-98	327.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria,4DZUQ@85010|Pseudonocardiales	201174|Actinobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
CMS3_k127_3760087_12	477641.MODMU_1923	2.171e-27	122.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,4EWGW@85013|Frankiales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
CMS3_k127_3760087_13	1316936.K678_15566	6.106e-26	112.0	COG0642@1|root,COG3829@1|root,COG4191@1|root,COG5000@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2JQQV@204441|Rhodospirillales	204441|Rhodospirillales	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_4,PAS_7,PAS_9
CMS3_k127_3760087_19	596151.DesfrDRAFT_1127	5.387e-06	54.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,435QG@68525|delta/epsilon subdivisions,2X04R@28221|Deltaproteobacteria,2MAHT@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
CMS3_k127_3760087_10	1121403.AUCV01000014_gene4616	3.707e-32	134.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PDY@68525|delta/epsilon subdivisions,2WMD0@28221|Deltaproteobacteria,2MPRX@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9
CMS3_k127_3766844_7	479431.Namu_4107	4.9e-81	285.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4ERCG@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM 2-oxoglutarate dehydrogenase, E2 component	-	-	2.3.1.168,2.3.1.61	ko:K00658,ko:K09699	ko00020,ko00280,ko00310,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00280,map00310,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00036	R02570,R02571,R02662,R03174,R04097,R08549,R10998	RC00004,RC02727,RC02833,RC02870	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CMS3_k127_3766844_5	1382304.JNIL01000001_gene313	5.015e-96	335.0	COG0320@1|root,COG0320@2|Bacteria,1TQM4@1239|Firmicutes,4H9SW@91061|Bacilli,2785A@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
CMS3_k127_3766844_3	1313172.YM304_15060	3.133e-112	377.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4CMRJ@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
CMS3_k127_3766844_15	1121380.JNIW01000006_gene494	4.212e-14	76.0	COG1922@1|root,COG1922@2|Bacteria,1WJJ7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Glycosyl transferase WecB/TagA/CpsF family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
CMS3_k127_3766844_10	1123389.ATXJ01000021_gene1074	3.404e-44	167.0	COG1922@1|root,COG1922@2|Bacteria,1WJJ7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Glycosyl transferase WecB/TagA/CpsF family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
CMS3_k127_3766844_9	1283300.ATXB01000001_gene1495	1.651e-48	184.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,1RREJ@1236|Gammaproteobacteria,1XG6S@135618|Methylococcales	135618|Methylococcales	G	Domain of unknown function (DUF3473)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
CMS3_k127_3766844_1	391625.PPSIR1_28621	6.374e-200	646.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,2YUJ3@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
CMS3_k127_3766844_14	1229780.BN381_210111	5.584e-15	83.0	2C8AG@1|root,33SQR@2|Bacteria,2H3BF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3766844_11	1304865.JAGF01000001_gene3122	4.305e-42	161.0	COG2096@1|root,COG2096@2|Bacteria,2GMHN@201174|Actinobacteria	201174|Actinobacteria	S	adenosyltransferase	yvqK	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
CMS3_k127_3766844_4	1394178.AWOO02000084_gene1153	2.818e-105	365.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4EHZN@85012|Streptosporangiales	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
CMS3_k127_3766844_13	351607.Acel_1209	3.923e-20	98.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP
CMS3_k127_3766844_2	1144275.COCOR_06186	1.446e-122	404.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,1MW7H@1224|Proteobacteria,42NEC@68525|delta/epsilon subdivisions,2WK08@28221|Deltaproteobacteria,2YUA5@29|Myxococcales	28221|Deltaproteobacteria	HP	domain protein	moeB1	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
CMS3_k127_3766844_8	1120954.ATXE01000001_gene1503	1.365e-49	186.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4DWS0@85009|Propionibacteriales	201174|Actinobacteria	K	Sir2 family	cobB2	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
CMS3_k127_3766844_6	251229.Chro_2995	9.679e-90	326.0	COG0744@1|root,COG0744@2|Bacteria,1G1XF@1117|Cyanobacteria,3VIDV@52604|Pleurocapsales	1117|Cyanobacteria	M	PFAM Penicillin binding protein transpeptidase domain	mrcB	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
CMS3_k127_3766844_0	525909.Afer_0726	1.372e-209	662.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4CMX5@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
CMS3_k127_3766844_16	1184609.KILIM_014_00080	4.464e-08	64.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4F7T9@85018|Dermatophilaceae	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_3766844_12	1312959.KI914672_gene3453	8.363e-40	158.0	COG3745@1|root,COG3745@2|Bacteria,2INHS@201174|Actinobacteria	201174|Actinobacteria	U	Pilus assembly protein	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
CMS3_k127_3842337_7	404589.Anae109_1775	4.683e-26	110.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,42ZD0@68525|delta/epsilon subdivisions,2WU4P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
CMS3_k127_3842337_6	382464.ABSI01000023_gene533	1.495e-36	147.0	COG1825@1|root,COG1825@2|Bacteria,46SZS@74201|Verrucomicrobia,2IUP1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
CMS3_k127_3842337_4	1206733.BAGC01000051_gene2600	1.251e-46	174.0	COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,4FWYC@85025|Nocardiaceae	201174|Actinobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
CMS3_k127_3842337_1	1027371.GOALK_067_00550	1.501e-206	655.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4GBHD@85026|Gordoniaceae	201174|Actinobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
CMS3_k127_3842337_5	1380390.JIAT01000010_gene4305	2.563e-40	156.0	COG0558@1|root,COG0558@2|Bacteria,2GK5D@201174|Actinobacteria,4CQIK@84995|Rubrobacteria	84995|Rubrobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS3_k127_3842337_0	996637.SGM_5933	1.422e-286	916.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
CMS3_k127_3842337_8	756499.Desde_0101	1.093e-11	75.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,25C37@186801|Clostridia,261JY@186807|Peptococcaceae	186801|Clostridia	M	peptidyl-prolyl isomerase	-	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Cu_amine_oxidN1,Rotamase_2,Rotamase_3,SurA_N_3
CMS3_k127_3842337_3	1313172.YM304_33140	2.285e-95	332.0	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria,4CN31@84992|Acidimicrobiia	84992|Acidimicrobiia	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG
CMS3_k127_3842337_2	765910.MARPU_02035	1.976e-159	519.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1WXUR@135613|Chromatiales	135613|Chromatiales	P	PFAM Na Picotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
CMS3_k127_3873409_1	1283283.ATXA01000004_gene4400	3.174e-133	439.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4ERJ2@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
CMS3_k127_3873409_2	765910.MARPU_10005	2.012e-22	108.0	COG0589@1|root,COG0589@2|Bacteria,1NAHQ@1224|Proteobacteria	1224|Proteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_3873409_0	1121861.KB899912_gene1111	1.961e-136	445.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRII@28211|Alphaproteobacteria,2JQB3@204441|Rhodospirillales	204441|Rhodospirillales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_3895598_3	272134.KB731326_gene263	5.303e-31	131.0	COG0640@1|root,COG0640@2|Bacteria,1G7VI@1117|Cyanobacteria,1HG3F@1150|Oscillatoriales	1117|Cyanobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
CMS3_k127_3895598_2	219305.MCAG_01078	1.234e-34	143.0	COG1280@1|root,COG1280@2|Bacteria,2IIQ3@201174|Actinobacteria,4DDUC@85008|Micromonosporales	201174|Actinobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
CMS3_k127_3895598_4	436229.JOEH01000012_gene5055	3.489e-20	94.0	2E8ZP@1|root,33396@2|Bacteria,2IS4U@201174|Actinobacteria,2NJ8Q@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3895598_5	754252.PFREUD_13190	0.0003889	50.0	COG0558@1|root,COG0558@2|Bacteria,2GK5D@201174|Actinobacteria,4DQPW@85009|Propionibacteriales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS3_k127_3895598_0	861299.J421_1425	2.631e-68	245.0	COG0682@1|root,COG0682@2|Bacteria	2|Bacteria	M	lipoprotein biosynthetic process	-	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CMS3_k127_3895598_1	1206730.BAGA01000079_gene1310	2.262e-55	197.0	COG1964@1|root,COG1964@2|Bacteria,2I9RQ@201174|Actinobacteria,4FU0I@85025|Nocardiaceae	201174|Actinobacteria	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS3_k127_3897495_9	33876.JNXY01000016_gene7055	2.598e-14	78.0	COG4106@1|root,COG4106@2|Bacteria,2GJMG@201174|Actinobacteria,4D92Q@85008|Micromonosporales	201174|Actinobacteria	S	Methyltransferase small domain	tam	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044424,GO:0044464,GO:0051704	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_23,Methyltransf_25
CMS3_k127_3897495_7	1037409.BJ6T_70260	1.834e-45	171.0	COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,2TU5T@28211|Alphaproteobacteria,3JXPE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate	tam	-	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS3_k127_3897495_5	937777.Deipe_2804	1.652e-50	191.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS3_k127_3897495_1	351160.RCIX872	2.809e-84	294.0	COG2234@1|root,arCOG02959@2157|Archaea	2157|Archaea	S	Peptidase M28	ywaD2	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
CMS3_k127_3897495_8	391037.Sare_0439	1.671e-43	166.0	COG4292@1|root,COG4292@2|Bacteria,2GJPB@201174|Actinobacteria,4D8ES@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial low temperature requirement A protein (LtrA)	ltrA	-	-	-	-	-	-	-	-	-	-	-	LtrA
CMS3_k127_3897495_10	391037.Sare_0439	0.0001857	44.0	COG4292@1|root,COG4292@2|Bacteria,2GJPB@201174|Actinobacteria,4D8ES@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial low temperature requirement A protein (LtrA)	ltrA	-	-	-	-	-	-	-	-	-	-	-	LtrA
CMS3_k127_3897495_2	1430440.MGMSRv2_3361	1.539e-78	272.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2TSKN@28211|Alphaproteobacteria,2JPIS@204441|Rhodospirillales	204441|Rhodospirillales	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
CMS3_k127_3897495_4	118161.KB235922_gene2997	3.112e-57	211.0	COG0062@1|root,COG0062@2|Bacteria	2|Bacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
CMS3_k127_3897495_6	344747.PM8797T_12618	2.065e-49	188.0	COG1011@1|root,COG1011@2|Bacteria,2IZ1C@203682|Planctomycetes	203682|Planctomycetes	S	cryptic haloacid dehalogenase 1	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS3_k127_3897495_3	313589.JNB_16464	1.329e-73	254.0	2AP53@1|root,32UTP@2|Bacteria,2I8BG@201174|Actinobacteria,4FG4B@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3897495_0	1313172.YM304_33630	3.052e-291	930.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1,Thiol-ester_cl
CMS3_k127_3918110_4	485918.Cpin_3448	6.259e-64	224.0	COG0167@1|root,COG1146@1|root,COG0167@2|Bacteria,COG1146@2|Bacteria,4NGSB@976|Bacteroidetes,1IUH6@117747|Sphingobacteriia	976|Bacteroidetes	C	dihydroorotate dehydrogenase	-	-	1.3.1.1,1.3.98.1	ko:K00226,ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046,M00051	R00977,R01414,R01867,R11026	RC00051,RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_21
CMS3_k127_3918110_7	1304865.JAGF01000001_gene1543	1.301e-36	147.0	COG3629@1|root,COG3629@2|Bacteria,2IC17@201174|Actinobacteria	201174|Actinobacteria	T	DNA-binding transcriptional activator of the SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
CMS3_k127_3918110_1	926560.KE387023_gene3745	2.178e-108	363.0	COG4870@1|root,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	3.4.22.15	ko:K01365,ko:K14475	ko04140,ko04142,ko04145,ko04210,ko04612,ko05143,ko05205,ko05323,ko05418,map04140,map04142,map04145,map04210,map04612,map05143,map05205,map05323,map05418	-	-	-	ko00000,ko00001,ko00537,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I42,Peptidase_C1
CMS3_k127_3918110_11	694440.JOMF01000004_gene1431	1.29e-13	75.0	COG5513@1|root,arCOG03544@2157|Archaea	2157|Archaea	S	Chagasin family peptidase inhibitor I42	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	Inhibitor_I42
CMS3_k127_3918110_0	1122135.KB893144_gene1397	5.18e-154	494.0	COG3938@1|root,COG3938@2|Bacteria,1N02K@1224|Proteobacteria,2VGM8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the proline racemase family	-	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0050346	-	-	-	-	-	-	-	-	-	-	Pro_racemase
CMS3_k127_3918110_10	1380390.JIAT01000013_gene31	1.558e-16	85.0	28TIQ@1|root,2ZFSJ@2|Bacteria,2I6IR@201174|Actinobacteria,4CSHG@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3918110_6	1121440.AUMA01000008_gene842	5.086e-39	158.0	COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria,1R6YN@1224|Proteobacteria,42Q4G@68525|delta/epsilon subdivisions,2WJM9@28221|Deltaproteobacteria,2M947@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM Metal-dependent hydrolase HDOD	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Response_reg
CMS3_k127_3918110_9	1380347.JNII01000007_gene185	1.03e-20	96.0	2BKPP@1|root,32F5B@2|Bacteria,2GZGW@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_2
CMS3_k127_3918110_2	1122138.AQUZ01000056_gene6929	4.466e-96	318.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4DPH5@85009|Propionibacteriales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_3918110_3	1380347.JNII01000007_gene187	6.008e-84	298.0	COG0642@1|root,COG0642@2|Bacteria,2I2YP@201174|Actinobacteria	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_3918110_5	696281.Desru_0782	3.869e-47	184.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,260IY@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
CMS3_k127_3918110_13	1502852.FG94_02403	1.599e-10	72.0	COG0664@1|root,COG0664@2|Bacteria,1N4C9@1224|Proteobacteria,2VVJC@28216|Betaproteobacteria,4761J@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
CMS3_k127_3918110_8	706587.Desti_2505	4.552e-22	113.0	COG0664@1|root,COG1413@1|root,COG3202@1|root,COG0664@2|Bacteria,COG1413@2|Bacteria,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	CP_0465	-	-	ko:K15762	ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220	M00538	R02550,R03562,R05666,R09513	RC00269,RC00490,RC02556	ko00000,ko00001,ko00002	-	-	-	HEAT_2,HTH_Crp_2,cNMP_binding
CMS3_k127_3918110_14	469383.Cwoe_5808	1.773e-08	64.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,4CPNY@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K21564	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CMS3_k127_3937897_4	1382356.JQMP01000003_gene1468	4.117e-40	155.0	COG1131@1|root,COG1131@2|Bacteria,2G6HA@200795|Chloroflexi,27Z66@189775|Thermomicrobia	189775|Thermomicrobia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_3937897_1	118166.JH976537_gene4842	6.572e-60	215.0	COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria,1HAGW@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
CMS3_k127_3937897_0	1122176.KB903576_gene4887	3.702e-189	623.0	COG1640@1|root,COG1640@2|Bacteria,4NF7Z@976|Bacteroidetes,1IPKN@117747|Sphingobacteriia	976|Bacteroidetes	G	PFAM Glycoside hydrolase, family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	CBM_20,Glyco_hydro_77
CMS3_k127_3937897_3	1313172.YM304_20890	1.808e-51	195.0	COG4427@1|root,COG4427@2|Bacteria,2HVQW@201174|Actinobacteria,4CNUG@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Uncharacterized protein conserved in bacteria (DUF2332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2332
CMS3_k127_3937897_2	1121370.AQUY01000002_gene1846	6.734e-58	205.0	COG1120@1|root,COG1120@2|Bacteria,2I5PA@201174|Actinobacteria	201174|Actinobacteria	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS3_k127_3948286_1	324831.LGAS_0661	1.808e-15	78.0	COG1475@1|root,COG1475@2|Bacteria	2|Bacteria	K	chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase,ParBc
CMS3_k127_3948286_0	195250.CM001776_gene2551	3.981e-21	109.0	COG2931@1|root,COG3209@1|root,COG2931@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,RHS_repeat,VCBS
CMS3_k127_3956509_1	240016.ABIZ01000001_gene2203	1.703e-33	131.0	COG2021@1|root,COG2021@2|Bacteria,46U58@74201|Verrucomicrobia,2ITGZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	alpha/beta hydrolase fold	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
CMS3_k127_3956509_0	383372.Rcas_0265	1.343e-91	321.0	COG0596@1|root,COG0596@2|Bacteria,2G6Y2@200795|Chloroflexi	200795|Chloroflexi	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
CMS3_k127_3999276_17	573061.Clocel_2465	1.199e-16	92.0	COG2931@1|root,COG2931@2|Bacteria,1U2V0@1239|Firmicutes,24BFA@186801|Clostridia	186801|Clostridia	Q	PFAM Hemolysin-type calcium-binding region	-	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,HemolysinCabind
CMS3_k127_3999276_0	760568.Desku_1733	8.786e-141	474.0	COG1086@1|root,COG1086@2|Bacteria,1TR3W@1239|Firmicutes,247PW@186801|Clostridia,26076@186807|Peptococcaceae	186801|Clostridia	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_syn_2C,Polysacc_synt_2
CMS3_k127_3999276_2	395493.BegalDRAFT_2231	9.849e-134	439.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RMCS@1236|Gammaproteobacteria,461RD@72273|Thiotrichales	72273|Thiotrichales	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS3_k127_3999276_10	1286631.X805_21660	1.652e-58	209.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VQBN@28216|Betaproteobacteria,1KKM2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Sugar transferase	bplG	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
CMS3_k127_3999276_4	227377.CBU_0841	5.146e-104	350.0	COG0438@1|root,COG0707@1|root,COG0438@2|Bacteria,COG0707@2|Bacteria,1N0DG@1224|Proteobacteria,1S0D6@1236|Gammaproteobacteria,1JFE2@118969|Legionellales	118969|Legionellales	M	Glycosyl transferases group 1	-	-	-	ko:K21011	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	Glyco_trans_4_2,Glycos_transf_1
CMS3_k127_3999276_14	1464048.JNZS01000033_gene2819	2.986e-28	126.0	COG0457@1|root,COG0457@2|Bacteria,2I61K@201174|Actinobacteria,4DMQM@85008|Micromonosporales	201174|Actinobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
CMS3_k127_3999276_9	383372.Rcas_0498	8.914e-67	248.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
CMS3_k127_3999276_20	1192759.AKIB01000014_gene1750	1.744e-11	77.0	COG0615@1|root,COG0615@2|Bacteria,1N9T6@1224|Proteobacteria,2TX79@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IM	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
CMS3_k127_3999276_18	598467.BrE312_3054	7.118e-14	85.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	protein involved in exopolysaccharide biosynthesis	wzc	-	-	ko:K16692	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_31,GNVR,Wzz
CMS3_k127_3999276_11	637905.SVI_1922	7.554e-42	168.0	COG3291@1|root,COG5640@1|root,COG3291@2|Bacteria,COG5640@2|Bacteria,1PDUK@1224|Proteobacteria,1S8QS@1236|Gammaproteobacteria,2Q8NA@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Pregnancy-associated plasma protein-A	-	-	-	-	-	-	-	-	-	-	-	-	PKD,PPC,Peptidase_M43
CMS3_k127_3999276_19	1121924.ATWH01000001_gene4299	1.861e-12	72.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4FKX3@85023|Microbacteriaceae	201174|Actinobacteria	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
CMS3_k127_3999276_13	710687.KI912270_gene2635	5.67e-30	123.0	COG3209@1|root,COG4254@1|root,COG5184@1|root,COG3209@2|Bacteria,COG4254@2|Bacteria,COG5184@2|Bacteria,2I60K@201174|Actinobacteria,2375A@1762|Mycobacteriaceae	201174|Actinobacteria	M	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,RCC1_2
CMS3_k127_3999276_3	1120983.KB894574_gene833	2.675e-107	369.0	COG1409@1|root,COG1409@2|Bacteria,1QI4K@1224|Proteobacteria,2TV5Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS3_k127_3999276_5	1123242.JH636435_gene796	5.279e-93	326.0	COG0477@1|root,COG0477@2|Bacteria,2J4Z6@203682|Planctomycetes	203682|Planctomycetes	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_3999276_8	1122135.KB893135_gene1076	1.135e-68	244.0	COG0697@1|root,COG0697@2|Bacteria,1R4G2@1224|Proteobacteria,2TTS7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_3999276_7	926569.ANT_01800	5.576e-73	265.0	COG0395@1|root,COG0395@2|Bacteria,2G5SY@200795|Chloroflexi	200795|Chloroflexi	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17317	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	BPD_transp_1
CMS3_k127_3999276_12	420324.KI911947_gene5535	7.883e-40	169.0	COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,2U06F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidoreductase	socC	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_3999276_22	405948.SACE_5003	3.759e-05	52.0	COG2197@1|root,COG2197@2|Bacteria,2IE0X@201174|Actinobacteria	201174|Actinobacteria	K	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_3999276_23	981369.JQMJ01000004_gene121	0.0005504	49.0	COG1595@1|root,COG1595@2|Bacteria,2IC8V@201174|Actinobacteria,2NIKR@228398|Streptacidiphilus	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3999276_21	1108045.GORHZ_154_00240	4.351e-08	60.0	COG4978@1|root,COG4978@2|Bacteria,2HV0Y@201174|Actinobacteria,4GFEK@85026|Gordoniaceae	201174|Actinobacteria	KT	Bacterial transcription activator, effector binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
CMS3_k127_3999276_1	1246995.AFR_01125	3.988e-135	451.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4D8P2@85008|Micromonosporales	201174|Actinobacteria	V	COG0577 ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_3999276_6	1394178.AWOO02000011_gene3949	3.661e-83	284.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_3999276_15	1150864.MILUP08_46831	1.948e-27	118.0	COG3409@1|root,COG3409@2|Bacteria,2I9HW@201174|Actinobacteria,4DAG2@85008|Micromonosporales	201174|Actinobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,PG_binding_1
CMS3_k127_3999276_16	1137269.AZWL01000016_gene297	2.524e-25	112.0	COG3409@1|root,COG3409@2|Bacteria,2I9HW@201174|Actinobacteria	201174|Actinobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,PG_binding_1
CMS3_k127_400233_0	102129.Lepto7375DRAFT_2106	1.591e-115	386.0	COG2021@1|root,COG2021@2|Bacteria,1G4G5@1117|Cyanobacteria,1HHP2@1150|Oscillatoriales	1117|Cyanobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
CMS3_k127_400233_5	313612.L8106_01087	5.662e-15	86.0	COG0810@1|root,COG2931@1|root,COG0810@2|Bacteria,COG2931@2|Bacteria,1G13Z@1117|Cyanobacteria,1H9F4@1150|Oscillatoriales	1117|Cyanobacteria	Q	RTX toxins and related Ca2 binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	CAP,HemolysinCabind
CMS3_k127_400233_3	706587.Desti_4505	4.875e-55	196.0	COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,42U27@68525|delta/epsilon subdivisions,2WR2V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
CMS3_k127_400233_2	192952.MM_3157	1.601e-79	279.0	COG1680@1|root,arCOG00771@2157|Archaea	2157|Archaea	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A1202	Beta-lactamase
CMS3_k127_400233_4	345341.KUTG_05962	7.642e-19	90.0	COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,2H1NS@201174|Actinobacteria,4E1WI@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NB-ARC,TPR_12,TPR_7,Trans_reg_C
CMS3_k127_400233_1	2002.JOEQ01000042_gene5939	1.568e-106	372.0	COG2319@1|root,COG3629@1|root,COG2319@2|Bacteria,COG3629@2|Bacteria,2GJN3@201174|Actinobacteria,4EMXK@85012|Streptosporangiales	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,HTH_31,WD40
CMS3_k127_4006109_0	1229780.BN381_420007	5.088e-286	894.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,3UWC3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
CMS3_k127_4006109_5	1284679.HMPREF1626_10060	1.737e-30	129.0	COG0237@1|root,COG2039@1|root,COG0237@2|Bacteria,COG2039@2|Bacteria,2GN96@201174|Actinobacteria,4D5UC@85005|Actinomycetales	201174|Actinobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE,GrpB
CMS3_k127_4006109_7	240015.ACP_1323	8.944e-20	105.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,3Y2ZI@57723|Acidobacteria,2JI9X@204432|Acidobacteriia	204432|Acidobacteriia	T	Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
CMS3_k127_4006109_6	1385520.N802_15905	2.05e-30	132.0	COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria,4FGN8@85021|Intrasporangiaceae	201174|Actinobacteria	T	LuxR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_4006109_4	338963.Pcar_1756	1.702e-30	137.0	COG1287@1|root,COG1287@2|Bacteria,1N1IK@1224|Proteobacteria,42RRN@68525|delta/epsilon subdivisions,2WNAY@28221|Deltaproteobacteria,43SI2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4006109_2	309801.trd_1009	8.76e-54	204.0	COG2064@1|root,COG2064@2|Bacteria,2G6CF@200795|Chloroflexi,27XSY@189775|Thermomicrobia	189775|Thermomicrobia	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
CMS3_k127_4006109_3	1380370.JIBA01000003_gene2733	1.059e-51	198.0	COG2304@1|root,COG4965@1|root,COG2304@2|Bacteria,COG4965@2|Bacteria,2H577@201174|Actinobacteria,4FFVW@85021|Intrasporangiaceae	201174|Actinobacteria	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF,VWA_2
CMS3_k127_4006109_1	110319.CF8_2739	1.578e-82	277.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4DPMF@85009|Propionibacteriales	201174|Actinobacteria	U	Type II/IV secretion system protein	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
CMS3_k127_4007911_13	1444309.JAQG01000177_gene4402	0.0008902	49.0	2C5RJ@1|root,318NV@2|Bacteria,1V8CJ@1239|Firmicutes,4HJF7@91061|Bacilli,275E6@186822|Paenibacillaceae	91061|Bacilli	S	Sigma factor regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Sigma_reg_C,Sigma_reg_N
CMS3_k127_4007911_3	1906.SFRA_16800	9.847e-96	328.0	COG2807@1|root,COG2807@2|Bacteria,2I37C@201174|Actinobacteria	201174|Actinobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_4007911_1	1122134.KB893650_gene33	9.698e-158	510.0	COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,1RPY3@1236|Gammaproteobacteria,1XMD8@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
CMS3_k127_4007911_2	756272.Plabr_2410	4.094e-121	396.0	COG2084@1|root,COG2084@2|Bacteria,2IWXN@203682|Planctomycetes	203682|Planctomycetes	C	COG2084 3-hydroxyisobutyrate dehydrogenase and related	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
CMS3_k127_4007911_8	326427.Cagg_3808	1.672e-44	167.0	COG1528@1|root,COG1528@2|Bacteria,2G8JG@200795|Chloroflexi,37728@32061|Chloroflexia	32061|Chloroflexia	C	Iron-storage protein	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
CMS3_k127_4007911_4	316274.Haur_2171	8.891e-64	230.0	COG2197@1|root,COG2197@2|Bacteria,2G6K1@200795|Chloroflexi,376D3@32061|Chloroflexia	32061|Chloroflexia	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_4007911_6	316274.Haur_2170	2.074e-49	192.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
CMS3_k127_4007911_10	926550.CLDAP_20290	8.42e-35	138.0	COG0346@1|root,COG0346@2|Bacteria,2G8UR@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_4007911_5	446468.Ndas_1605	1.193e-62	223.0	COG3467@1|root,COG3467@2|Bacteria,2GJ76@201174|Actinobacteria,4EG1B@85012|Streptosporangiales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
CMS3_k127_4007911_7	926550.CLDAP_11630	8.478e-49	184.0	COG2452@1|root,COG4936@1|root,COG2452@2|Bacteria,COG4936@2|Bacteria	2|Bacteria	KT	Sensory domain found in PocR	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HTH_17,PocR
CMS3_k127_4007911_0	1385519.N801_12760	2.997e-183	581.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria,4FFV5@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
CMS3_k127_4007911_11	1121439.dsat_1462	4.129e-12	77.0	COG2427@1|root,COG2427@2|Bacteria,1P6AT@1224|Proteobacteria,43355@68525|delta/epsilon subdivisions,2WXWE@28221|Deltaproteobacteria,2MBQA@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
CMS3_k127_4007911_9	1184607.AUCHE_22_00930	8.497e-44	161.0	COG2920@1|root,COG2920@2|Bacteria,2IQB2@201174|Actinobacteria	201174|Actinobacteria	P	PFAM DsrC family protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
CMS3_k127_4007911_12	1043493.BBLU01000020_gene1081	6.874e-11	63.0	COG2210@1|root,COG2210@2|Bacteria,2IFXH@201174|Actinobacteria	201174|Actinobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
CMS3_k127_4036482_5	1454010.JEOE01000044_gene1545	1.914e-21	96.0	2E63U@1|root,330SV@2|Bacteria,2GSXM@201174|Actinobacteria,4F2VH@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4036482_0	710696.Intca_0489	2.997e-128	427.0	COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria,4FIKZ@85021|Intrasporangiaceae	201174|Actinobacteria	M	Peptidase inhibitor I9	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,PKD,Peptidase_S8
CMS3_k127_4036482_4	1120953.AUBH01000004_gene3093	3.371e-30	123.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,464PM@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	COG1404 Subtilisin-like serine proteases	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PKD,Peptidase_S8
CMS3_k127_4036482_7	318161.Sden_2996	2.798e-05	48.0	COG0464@1|root,COG0464@2|Bacteria,1NF48@1224|Proteobacteria,1RQNE@1236|Gammaproteobacteria,2QEMF@267890|Shewanellaceae	1236|Gammaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS3_k127_4036482_3	134676.ACPL_6071	2.578e-43	162.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4DB2V@85008|Micromonosporales	201174|Actinobacteria	L	Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS3_k127_4036482_6	1416759.AYMR01000009_gene3212	1.528e-19	90.0	COG4118@1|root,COG4118@2|Bacteria,2GW5I@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
CMS3_k127_4036482_2	469383.Cwoe_3714	4.573e-53	189.0	COG1487@1|root,COG1487@2|Bacteria,2IGMY@201174|Actinobacteria,4CT46@84995|Rubrobacteria	84995|Rubrobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS3_k127_4036482_1	675635.Psed_6858	1.798e-69	241.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4DY23@85010|Pseudonocardiales	201174|Actinobacteria	L	PFAM Transposase, mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
CMS3_k127_4036924_6	1499967.BAYZ01000083_gene1022	5.014e-61	219.0	COG3049@1|root,COG3049@2|Bacteria	2|Bacteria	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	AAT,CBAH
CMS3_k127_4036924_9	936548.HMPREF1136_0727	1.332e-19	93.0	COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,4D4KC@85005|Actinomycetales	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS3_k127_4036924_13	1313172.YM304_23250	5.564e-12	75.0	COG0730@1|root,COG0730@2|Bacteria,2HGFT@201174|Actinobacteria,4CNDC@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS3_k127_4036924_11	1196322.A370_00652	1.346e-14	80.0	COG1988@1|root,COG1988@2|Bacteria,1V7VD@1239|Firmicutes,24IED@186801|Clostridia,36J3U@31979|Clostridiaceae	186801|Clostridia	S	membrane-bound metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	YdjM
CMS3_k127_4036924_15	1313172.YM304_18960	2.886e-06	57.0	COG1579@1|root,COG1579@2|Bacteria	2|Bacteria	-	-	CP_0228	-	3.5.4.16	ko:K07164,ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	zf-RING_7
CMS3_k127_4036924_5	575540.Isop_2843	2.645e-64	234.0	COG0327@1|root,COG3323@1|root,COG0327@2|Bacteria,COG3323@2|Bacteria,2IXMR@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM dinuclear metal center protein, YbgI SA1388 family	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
CMS3_k127_4036924_10	522306.CAP2UW1_2360	1.319e-14	81.0	COG0454@1|root,COG0456@2|Bacteria,1QZ7S@1224|Proteobacteria,2WHVJ@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_4036924_17	1297742.A176_00262	0.0003256	53.0	COG1470@1|root,COG2885@1|root,COG4719@1|root,COG1470@2|Bacteria,COG2885@2|Bacteria,COG4719@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3
CMS3_k127_4036924_4	469383.Cwoe_4738	2.256e-95	316.0	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4CQJ5@84995|Rubrobacteria	84995|Rubrobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
CMS3_k127_4036924_2	1028800.RG540_CH33690	5.64e-129	424.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TTU3@28211|Alphaproteobacteria,4B9HQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	aruH	-	2.6.1.1,2.6.1.84	ko:K00812,ko:K12252	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052,R08197	RC00006,RC00008	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_4036924_1	1049564.TevJSym_ac01750	3.572e-133	430.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1J5NQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk2	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
CMS3_k127_4036924_8	926569.ANT_27860	5.453e-27	121.0	COG3595@1|root,COG3595@2|Bacteria,2G73J@200795|Chloroflexi	200795|Chloroflexi	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
CMS3_k127_4036924_7	1032480.MLP_24830	1.319e-33	137.0	COG1595@1|root,COG1595@2|Bacteria,2HG34@201174|Actinobacteria,4DWA5@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_4036924_12	861208.AGROH133_07462	3.663e-12	75.0	COG0665@1|root,COG0665@2|Bacteria,1R652@1224|Proteobacteria,2TV72@28211|Alphaproteobacteria,4B7D6@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Glycine D-amino acid oxidases (deaminating)	solA	-	-	-	-	-	-	-	-	-	-	-	DAO
CMS3_k127_4036924_3	926569.ANT_01050	1.72e-115	386.0	COG0240@1|root,COG0240@2|Bacteria,2G6HJ@200795|Chloroflexi	200795|Chloroflexi	C	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain	-	-	1.5.1.28	ko:K04940	-	-	-	-	ko00000,ko01000	-	-	-	NAD_Gly3P_dh_N,Octopine_DH
CMS3_k127_4036924_0	644966.Tmar_0906	4.058e-161	527.0	COG5012@1|root,COG5012@2|Bacteria,1UZP9@1239|Firmicutes,24CTM@186801|Clostridia	186801|Clostridia	S	Cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Met_asp_mut_E
CMS3_k127_4036924_16	1429046.RR21198_3660	9.081e-06	50.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
CMS3_k127_4071930_14	710696.Intca_1879	2.961e-09	66.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	pknD	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009405,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010565,GO:0016020,GO:0016021,GO:0016036,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031667,GO:0031668,GO:0031669,GO:0032091,GO:0033554,GO:0036211,GO:0042304,GO:0042594,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043393,GO:0043412,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051100,GO:0051704,GO:0051716,GO:0062012,GO:0062014,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08282,ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	NHL,Pkinase
CMS3_k127_4071930_15	1330700.JQNC01000003_gene552	1.083e-08	66.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,1WIGW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
CMS3_k127_4071930_16	670487.Ocepr_0101	7.067e-08	65.0	COG2010@1|root,COG2010@2|Bacteria,1WIF2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
CMS3_k127_4071930_17	745776.DGo_CA2019	3.461e-06	60.0	COG0457@1|root,COG0457@2|Bacteria,1WJ9G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,TPR_11,TPR_16,TPR_19,TPR_8
CMS3_k127_4071930_4	1146883.BLASA_0688	2.22e-44	174.0	COG4974@1|root,COG4974@2|Bacteria,2HD2H@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
CMS3_k127_4071930_18	1121447.JONL01000001_gene735	0.0002496	43.0	2EG8N@1|root,33A0G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4071930_8	298655.KI912266_gene2901	1.565e-29	121.0	COG1752@1|root,COG1752@2|Bacteria,2I9XW@201174|Actinobacteria	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
CMS3_k127_4071930_2	1123319.AUBE01000029_gene5158	4.803e-75	259.0	COG1752@1|root,COG1752@2|Bacteria,2I9XW@201174|Actinobacteria	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
CMS3_k127_4071930_13	1127134.NOCYR_2592	1.303e-15	87.0	COG3576@1|root,COG3576@2|Bacteria,2II3S@201174|Actinobacteria,4G174@85025|Nocardiaceae	201174|Actinobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_4071930_10	1304865.JAGF01000001_gene1568	2.42e-20	98.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx,Pyridox_ox_2
CMS3_k127_4071930_7	525909.Afer_1899	2.114e-36	147.0	COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,4CN59@84992|Acidimicrobiia	84992|Acidimicrobiia	J	RNA 2'-O ribose methyltransferase substrate binding	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
CMS3_k127_4071930_0	439235.Dalk_0769	5.264e-135	445.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,2MIN7@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
CMS3_k127_4071930_9	404589.Anae109_0978	1.68e-23	109.0	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,42U7W@68525|delta/epsilon subdivisions,2WQ9A@28221|Deltaproteobacteria,2YVEF@29|Myxococcales	28221|Deltaproteobacteria	C	glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS3_k127_4071930_1	1380394.JADL01000003_gene5182	1.923e-76	269.0	COG2267@1|root,COG2267@2|Bacteria,1NK3M@1224|Proteobacteria,2TRP8@28211|Alphaproteobacteria,2JS7D@204441|Rhodospirillales	204441|Rhodospirillales	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_4071930_11	679926.Mpet_0486	2.538e-20	100.0	arCOG14808@1|root,arCOG14808@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
CMS3_k127_4071930_12	1120954.ATXE01000004_gene242	2.398e-17	86.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4DPBH@85009|Propionibacteriales	201174|Actinobacteria	O	C-terminal, D2-small domain, of ClpB protein	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
CMS3_k127_4071930_6	227882.SAV_2600	4.039e-38	153.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria	201174|Actinobacteria	O	associated with various cellular activities	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
CMS3_k127_4071930_5	1380394.JADL01000005_gene5487	1.709e-40	156.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,2JPA7@204441|Rhodospirillales	204441|Rhodospirillales	I	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)	ispDF	-	2.7.7.60,4.6.1.12	ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
CMS3_k127_4071930_3	351607.Acel_0079	3.736e-52	195.0	COG4956@1|root,COG4956@2|Bacteria	2|Bacteria	S	nuclease activity	yacL	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	PIN,PIN_4,TRAM
CMS3_k127_4074372_2	1121877.JQKF01000004_gene1125	8.478e-124	409.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4CMPR@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
CMS3_k127_4074372_7	1120972.AUMH01000011_gene183	1.182e-25	113.0	COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,4HH88@91061|Bacilli,279QR@186823|Alicyclobacillaceae	91061|Bacilli	S	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
CMS3_k127_4074372_0	1380346.JNIH01000031_gene1013	1.048e-219	697.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
CMS3_k127_4074372_1	525909.Afer_0633	3.712e-158	511.0	COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4CMRA@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
CMS3_k127_4074372_4	561175.KB894094_gene1813	1.127e-58	220.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4EFKK@85012|Streptosporangiales	201174|Actinobacteria	M	Domain present in PSD-95, Dlg, and ZO-1/2.	rip1	GO:0008150,GO:0040007	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
CMS3_k127_4074372_3	1121468.AUBR01000029_gene1579	3.11e-98	334.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,2483M@186801|Clostridia,42F80@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06420	DXPR_C,DXP_redisom_C,DXP_reductoisom
CMS3_k127_4074372_6	105420.BBPO01000103_gene7320	3.825e-28	133.0	COG4589@1|root,COG4589@2|Bacteria,2GNWK@201174|Actinobacteria,2NFQP@228398|Streptacidiphilus	201174|Actinobacteria	S	Cytidylyltransferase family	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
CMS3_k127_4074372_5	351607.Acel_1539	2.139e-34	134.0	COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4ESC9@85013|Frankiales	201174|Actinobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
CMS3_k127_4108923_1	324602.Caur_1161	3.247e-205	648.0	COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
CMS3_k127_4108923_4	1211815.CBYP010000021_gene3282	3.841e-161	517.0	COG0448@1|root,COG0448@2|Bacteria,2I2EF@201174|Actinobacteria,4ERNH@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	GO:0000271,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901576	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
CMS3_k127_4108923_6	1313172.YM304_18910	3.135e-148	483.0	COG0297@1|root,COG0297@2|Bacteria,2GWGE@201174|Actinobacteria	201174|Actinobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
CMS3_k127_4108923_0	713586.KB900536_gene50	1.078e-295	923.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
CMS3_k127_4108923_3	446466.Cfla_1098	6.345e-168	550.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria,4F0SU@85016|Cellulomonadaceae	201174|Actinobacteria	G	Protein of unknown function (DUF3417)	glgP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
CMS3_k127_4108923_12	292459.STH3129	9.783e-71	254.0	COG1605@1|root,COG2876@1|root,COG1605@2|Bacteria,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia	186801|Clostridia	E	PFAM DAHP synthetase I	-	-	2.5.1.54,5.4.99.5	ko:K03856,ko:K04516	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022,M00024,M00025	R01715,R01826	RC00435,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,DAHP_synth_1
CMS3_k127_4108923_8	518766.Rmar_2209	7.267e-98	331.0	COG3173@1|root,COG3173@2|Bacteria,4NFE7@976|Bacteroidetes,1FJU1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS3_k127_4108923_10	909613.UO65_5417	3.117e-84	288.0	COG0109@1|root,COG0109@2|Bacteria,2GJMY@201174|Actinobacteria,4DXM2@85010|Pseudonocardiales	201174|Actinobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
CMS3_k127_4108923_13	1128421.JAGA01000002_gene1586	5.281e-53	198.0	COG1612@1|root,COG1612@2|Bacteria	2|Bacteria	O	heme a metabolic process	ctaB	-	2.5.1.141	ko:K02257,ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07411,R07412	RC00769,RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	3.D.4.4	-	-	COX15-CtaA,UbiA
CMS3_k127_4108923_16	309801.trd_A0259	6.623e-33	137.0	COG2267@1|root,COG2267@2|Bacteria,2GBHH@200795|Chloroflexi,27Y8T@189775|Thermomicrobia	189775|Thermomicrobia	I	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)	menH	-	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
CMS3_k127_4108923_18	1313172.YM304_12960	3.567e-32	137.0	COG2267@1|root,COG2267@2|Bacteria,2I79Z@201174|Actinobacteria	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_4108923_17	1128421.JAGA01000003_gene2807	6.63e-33	133.0	COG3411@1|root,COG3411@2|Bacteria	2|Bacteria	C	Ferredoxin	-	-	6.6.1.2	ko:K02230	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	-
CMS3_k127_4108923_9	1229520.ADIAL_0710	1.087e-97	329.0	COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,4HB6P@91061|Bacilli,27FPD@186828|Carnobacteriaceae	91061|Bacilli	E	AIR synthase related protein, C-terminal domain	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
CMS3_k127_4108923_11	1121445.ATUZ01000016_gene2596	1.515e-73	265.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2M94B@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
CMS3_k127_4108923_15	469383.Cwoe_5918	5.443e-37	150.0	COG0115@1|root,COG0115@2|Bacteria,2GN5Z@201174|Actinobacteria	201174|Actinobacteria	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CMS3_k127_4108923_2	552811.Dehly_0763	5.038e-169	547.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G8XD@200795|Chloroflexi,34CY9@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
CMS3_k127_4108923_5	1380394.JADL01000001_gene3072	1.508e-157	512.0	COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2TR20@28211|Alphaproteobacteria,2JPF7@204441|Rhodospirillales	204441|Rhodospirillales	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
CMS3_k127_4108923_14	1089553.Tph_c09520	9.204e-42	166.0	COG0287@1|root,COG4747@1|root,COG0287@2|Bacteria,COG4747@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia,42GDJ@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDH
CMS3_k127_4108923_7	498761.HM1_1923	1.976e-123	406.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia	186801|Clostridia	E	PFAM DAHP synthetase I	aroF1	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
CMS3_k127_4108923_19	1386089.N865_02250	3.836e-12	68.0	COG1396@1|root,COG1396@2|Bacteria,2IKVI@201174|Actinobacteria,4FGUQ@85021|Intrasporangiaceae	201174|Actinobacteria	K	DNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS3_k127_4149830_5	211114.JOEF01000028_gene7804	2.84e-32	135.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,4DXBH@85010|Pseudonocardiales	201174|Actinobacteria	C	e3 binding domain	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CMS3_k127_4149830_3	1232410.KI421428_gene1110	1.843e-112	380.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42N06@68525|delta/epsilon subdivisions,2WK5N@28221|Deltaproteobacteria,43T7Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	bkdB	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS3_k127_4149830_4	292459.STH411	1.599e-93	319.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia	186801|Clostridia	C	dehydrogenase, E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
CMS3_k127_4149830_2	392499.Swit_4534	7.152e-146	475.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,2K1AN@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS3_k127_4149830_1	477641.MODMU_2852	3.991e-146	484.0	COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,2GN7D@201174|Actinobacteria,4ERUR@85013|Frankiales	201174|Actinobacteria	EH	PFAM chorismate	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Chorismate_bind
CMS3_k127_4149830_0	1229780.BN381_80302	2.152e-175	573.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,3UW6P@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
CMS3_k127_4206300_0	667014.Thein_1982	7.33e-69	249.0	COG0569@1|root,COG0569@2|Bacteria,2GIEN@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Alanine dehydrogenase/PNT, C-terminal domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS3_k127_4206300_1	1380370.JIBA01000019_gene1075	8.17e-42	170.0	COG1316@1|root,COG1316@2|Bacteria,2IAW9@201174|Actinobacteria,4FG3U@85021|Intrasporangiaceae	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
CMS3_k127_4206300_2	2002.JOEQ01000016_gene7318	3.24e-21	94.0	COG1476@1|root,COG1476@2|Bacteria,2GQIU@201174|Actinobacteria,4EK4N@85012|Streptosporangiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
CMS3_k127_4206300_5	1304875.JAFZ01000001_gene1599	0.0004045	50.0	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
CMS3_k127_4206300_3	1146883.BLASA_2024	8.775e-05	46.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria	201174|Actinobacteria	NU	Type ii secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
CMS3_k127_4275860_0	443144.GM21_3762	7.86e-132	433.0	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,43CTG@68525|delta/epsilon subdivisions,2X810@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	OsmC-like protein	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4,OsmC
CMS3_k127_4275860_1	756272.Plabr_0902	1.124e-125	428.0	COG1696@1|root,COG1696@2|Bacteria,2IX06@203682|Planctomycetes	203682|Planctomycetes	M	membrane protein involved in D-alanine	-	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
CMS3_k127_4275860_7	1487953.JMKF01000056_gene4479	1.398e-07	63.0	COG2755@1|root,COG2755@2|Bacteria,1GBDF@1117|Cyanobacteria,1HF7B@1150|Oscillatoriales	1117|Cyanobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4275860_6	391626.OAN307_c03470	1.503e-08	62.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	mxaD	-	-	ko:K16260	ko00680,ko01120,map00680,map01120	-	-	-	ko00000,ko00001	-	-	-	Polyketide_cyc2
CMS3_k127_4275860_3	69279.BG36_00510	9.39e-54	196.0	COG1280@1|root,COG1280@2|Bacteria,1RBIQ@1224|Proteobacteria,2U7PS@28211|Alphaproteobacteria,43KVA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
CMS3_k127_4275860_5	179408.Osc7112_1799	1.67e-16	86.0	COG1308@1|root,COG1308@2|Bacteria,1G83N@1117|Cyanobacteria,1HC9J@1150|Oscillatoriales	1117|Cyanobacteria	K	Domain of unknown function (DUF4342)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
CMS3_k127_4275860_2	1894.JOER01000030_gene432	6.021e-85	289.0	COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
CMS3_k127_4275860_4	1137271.AZUM01000004_gene3959	5.919e-30	135.0	COG1983@1|root,COG1983@2|Bacteria,2GIVS@201174|Actinobacteria,4E1BF@85010|Pseudonocardiales	201174|Actinobacteria	KT	PFAM PspC domain	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
CMS3_k127_4337564_4	511051.CSE_06880	2.306e-12	68.0	COG0005@1|root,COG0005@2|Bacteria	2|Bacteria	F	purine-nucleoside phosphorylase activity	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
CMS3_k127_4337564_2	502025.Hoch_3596	3.74e-51	190.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WPKC@28221|Deltaproteobacteria,2YVGU@29|Myxococcales	28221|Deltaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
CMS3_k127_4337564_5	1120965.AUBV01000001_gene3366	2.635e-12	73.0	COG3118@1|root,COG3118@2|Bacteria,4NS6N@976|Bacteroidetes,47R18@768503|Cytophagia	976|Bacteroidetes	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS3_k127_4337564_0	553204.CORAM0001_0495	1.337e-103	351.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,22JXM@1653|Corynebacteriaceae	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadB2	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006635,GO:0008150,GO:0008152,GO:0008610,GO:0008691,GO:0009056,GO:0009058,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0030497,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0072330,GO:0075136,GO:1901575,GO:1901576	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0468	3HCDH,3HCDH_N
CMS3_k127_4337564_1	290399.Arth_0983	1.194e-96	325.0	COG0560@1|root,COG0560@2|Bacteria,2IF8R@201174|Actinobacteria	201174|Actinobacteria	E	Phosphoserine phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
CMS3_k127_4337564_3	253839.SSNG_03918	1.805e-49	182.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria	201174|Actinobacteria	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	ctpE	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
CMS3_k127_4343219_0	28444.JODQ01000001_gene2596	6.715e-130	455.0	COG0577@1|root,COG0577@2|Bacteria,2H997@201174|Actinobacteria,4EGB7@85012|Streptosporangiales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
CMS3_k127_4343219_1	1380346.JNIH01000007_gene1826	3.263e-08	64.0	COG0577@1|root,COG0577@2|Bacteria,2GNEX@201174|Actinobacteria	201174|Actinobacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
CMS3_k127_4381478_0	338963.Pcar_1328	8.067e-206	646.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,43S1C@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Phosphoribosylformylglycinamidine (FGAM) synthase	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
CMS3_k127_4381478_1	1232410.KI421413_gene538	1.177e-123	400.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,42MNY@68525|delta/epsilon subdivisions,2WJ6C@28221|Deltaproteobacteria,43S7F@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	CobB/CobQ-like glutamine amidotransferase domain	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
CMS3_k127_445604_9	649639.Bcell_0513	1.381e-40	164.0	COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,4HB9S@91061|Bacilli,1ZAY0@1386|Bacillus	91061|Bacilli	F	Belongs to the 5'-nucleotidase family	yfkN	-	3.1.3.5,3.1.3.6,3.1.4.16	ko:K01081,ko:K06931,ko:K08693	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000	-	-	iYO844.BSU07840	5_nucleotid_C,CBM_5_12,Metallophos
CMS3_k127_445604_6	37919.EP51_03950	7.092e-78	272.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,2GKB8@201174|Actinobacteria,4FY7G@85025|Nocardiaceae	201174|Actinobacteria	P	TrkA-N domain	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
CMS3_k127_445604_10	1235279.C772_02738	2.582e-12	71.0	COG0346@1|root,COG0346@2|Bacteria,1VCGT@1239|Firmicutes,4HKDV@91061|Bacilli,26FTE@186818|Planococcaceae	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_445604_8	1521187.JPIM01000097_gene2717	2.321e-62	219.0	COG2343@1|root,COG2343@2|Bacteria,2GARM@200795|Chloroflexi,3775Q@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
CMS3_k127_445604_5	219305.MCAG_05078	1.68e-80	287.0	COG1409@1|root,COG1409@2|Bacteria,2IM97@201174|Actinobacteria,4D9VR@85008|Micromonosporales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Metallophos
CMS3_k127_445604_4	1313172.YM304_34820	8.797e-99	330.0	COG0395@1|root,COG0395@2|Bacteria,2GK1V@201174|Actinobacteria	201174|Actinobacteria	G	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
CMS3_k127_445604_2	1313172.YM304_34830	1.953e-112	378.0	COG1175@1|root,COG1175@2|Bacteria,2IEK2@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05814	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
CMS3_k127_445604_1	1313172.YM304_34840	1.975e-153	503.0	COG1653@1|root,COG1653@2|Bacteria,2HP0P@201174|Actinobacteria	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
CMS3_k127_445604_0	446462.Amir_3077	6.56e-176	566.0	COG1012@1|root,COG1012@2|Bacteria,2HF1C@201174|Actinobacteria,4EA29@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
CMS3_k127_445604_3	58344.JOEL01000009_gene4988	2.024e-109	365.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS3_k127_445604_7	1121877.JQKF01000003_gene1542	9.912e-72	259.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,4CN0Y@84992|Acidimicrobiia	84992|Acidimicrobiia	U	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CMS3_k127_4469883_1	1227488.C477_02334	9.456e-24	109.0	arCOG03085@1|root,arCOG03085@2157|Archaea,2XWPM@28890|Euryarchaeota,23VFX@183963|Halobacteria	183963|Halobacteria	T	Putative sensor	-	-	-	-	-	-	-	-	-	-	-	-	Sensor
CMS3_k127_4469883_0	797302.Halru_0192	6.217e-35	153.0	COG1033@1|root,arCOG02174@2157|Archaea,2XT5A@28890|Euryarchaeota,23SV0@183963|Halobacteria	183963|Halobacteria	L	exporters of the RND superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
CMS3_k127_4477465_17	357808.RoseRS_2718	7.58e-34	138.0	COG0748@1|root,COG0748@2|Bacteria,2GBMI@200795|Chloroflexi,3782F@32061|Chloroflexia	32061|Chloroflexia	P	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
CMS3_k127_4477465_2	3218.PP1S135_118V6.1	3.707e-154	497.0	COG0436@1|root,KOG0257@2759|Eukaryota,37HWK@33090|Viridiplantae,3G9MN@35493|Streptophyta	35493|Streptophyta	E	Kynurenine--oxoglutarate transaminase	-	GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS3_k127_4477465_5	1380393.JHVP01000024_gene3307	1.063e-137	458.0	COG0671@1|root,COG1718@1|root,COG0671@2|Bacteria,COG1718@2|Bacteria	2|Bacteria	DT	cellular response to dsDNA	kdkA	-	2.7.1.166,3.6.1.27	ko:K11211,ko:K19302	ko00540,ko00550,map00540,map00550	-	R05627,R09767	RC00002,RC00078	ko00000,ko00001,ko01000,ko01011	-	-	-	Kdo,PAP2
CMS3_k127_4477465_18	1380356.JNIK01000018_gene823	3.354e-32	138.0	COG0671@1|root,COG0671@2|Bacteria,2GVMI@201174|Actinobacteria	201174|Actinobacteria	I	phosphoesterase, PA-phosphatase	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
CMS3_k127_4477465_21	1206737.BAGF01000150_gene6134	3.697e-24	113.0	COG0671@1|root,COG0671@2|Bacteria,2HYHW@201174|Actinobacteria,4G3GX@85025|Nocardiaceae	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
CMS3_k127_4477465_22	65393.PCC7424_2216	3.927e-24	115.0	COG1503@1|root,COG1503@2|Bacteria,1G29A@1117|Cyanobacteria,3KGPZ@43988|Cyanothece	1117|Cyanobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4477465_16	1380356.JNIK01000011_gene1782	5.874e-34	137.0	COG1595@1|root,COG1595@2|Bacteria,2GN5Y@201174|Actinobacteria,4ESZT@85013|Frankiales	201174|Actinobacteria	K	sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_4477465_11	558169.AGAV01000017_gene1080	6.008e-84	298.0	COG0405@1|root,COG0405@2|Bacteria,1TR9U@1239|Firmicutes,4HB23@91061|Bacilli	91061|Bacilli	E	gamma-glutamyltransferase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CMS3_k127_4477465_15	358681.BBR47_23070	3.943e-41	163.0	COG1752@1|root,COG1752@2|Bacteria,1TRJW@1239|Firmicutes,4HB8J@91061|Bacilli,26R0U@186822|Paenibacillaceae	91061|Bacilli	S	esterase of the alpha-beta hydrolase superfamily	yqhO	GO:0003674,GO:0003824,GO:0016787	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
CMS3_k127_4477465_20	345341.KUTG_07065	1.415e-29	123.0	COG1051@1|root,COG1051@2|Bacteria,2IQZT@201174|Actinobacteria,4E5NW@85010|Pseudonocardiales	201174|Actinobacteria	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS3_k127_4477465_19	1242864.D187_000561	1.4e-29	127.0	COG1309@1|root,COG1309@2|Bacteria,1N4J6@1224|Proteobacteria	1224|Proteobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
CMS3_k127_4477465_7	1313172.YM304_00980	5.315e-115	401.0	COG1948@1|root,COG4880@2|Bacteria,2I8JU@201174|Actinobacteria	201174|Actinobacteria	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
CMS3_k127_4477465_23	196162.Noca_4098	6.825e-18	95.0	2AE7Y@1|root,3141Y@2|Bacteria,2HDMT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4477465_1	1540257.JQMW01000011_gene1734	7.707e-159	516.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,36UI0@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS3_k127_4477465_9	1313172.YM304_01530	1.972e-105	352.0	COG1744@1|root,COG1744@2|Bacteria,2IEKS@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	-	-	-	-	-	-	-	-	-	Bmp
CMS3_k127_4477465_10	1313172.YM304_01540	8.691e-97	342.0	COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS3_k127_4477465_8	1313172.YM304_01550	1.858e-110	368.0	COG4603@1|root,COG4603@2|Bacteria,2GKAZ@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS3_k127_4477465_0	926569.ANT_14510	4.59e-245	777.0	COG1529@1|root,COG1529@2|Bacteria,2G5PH@200795|Chloroflexi	200795|Chloroflexi	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS3_k127_4477465_4	1382356.JQMP01000001_gene751	3.308e-140	461.0	COG1319@1|root,COG2080@1|root,COG1319@2|Bacteria,COG2080@2|Bacteria,2G5XD@200795|Chloroflexi	200795|Chloroflexi	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
CMS3_k127_4477465_14	266117.Rxyl_2842	6.446e-52	192.0	COG0590@1|root,COG0590@2|Bacteria,2I9KR@201174|Actinobacteria	201174|Actinobacteria	FJ	CMP dCMP deaminase, zinc-binding	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
CMS3_k127_4477465_6	765420.OSCT_2196	8.711e-123	407.0	COG1744@1|root,COG1744@2|Bacteria,2G6CN@200795|Chloroflexi	200795|Chloroflexi	M	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
CMS3_k127_4477465_3	864702.OsccyDRAFT_1800	3.565e-149	486.0	COG3845@1|root,COG3845@2|Bacteria,1G4UA@1117|Cyanobacteria,1HH79@1150|Oscillatoriales	1117|Cyanobacteria	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS3_k127_4477465_12	1125863.JAFN01000001_gene149	2.88e-82	287.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,42MWE@68525|delta/epsilon subdivisions,2WKIZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS3_k127_4477465_13	765420.OSCT_2199	2.289e-73	258.0	COG1079@1|root,COG1079@2|Bacteria,2G6CY@200795|Chloroflexi,377XG@32061|Chloroflexia	32061|Chloroflexia	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS3_k127_448777_12	469383.Cwoe_3159	1.313e-60	220.0	COG2050@1|root,COG2050@2|Bacteria,2HMKZ@201174|Actinobacteria,4CSHW@84995|Rubrobacteria	84995|Rubrobacteria	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
CMS3_k127_448777_10	485913.Krac_9346	2.508e-69	251.0	COG1073@1|root,COG1073@2|Bacteria,2G95Q@200795|Chloroflexi	200795|Chloroflexi	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DUF1100
CMS3_k127_448777_11	1463857.JOFZ01000001_gene5441	7.205e-63	230.0	COG2159@1|root,COG2159@2|Bacteria,2HEB4@201174|Actinobacteria	201174|Actinobacteria	CH	amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
CMS3_k127_448777_4	1120949.KB903324_gene3339	8.673e-130	429.0	COG1082@1|root,COG1082@2|Bacteria,2GN0M@201174|Actinobacteria,4DBKA@85008|Micromonosporales	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS3_k127_448777_24	1121861.KB899914_gene2088	3.487e-05	52.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2TT57@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_448777_21	1120950.KB892742_gene2956	3.635e-16	87.0	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,4DQ7D@85009|Propionibacteriales	201174|Actinobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
CMS3_k127_448777_0	926550.CLDAP_20730	0.0	1041.0	COG0058@1|root,COG0058@2|Bacteria,2G5KG@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycosyl transferase, family 35	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
CMS3_k127_448777_5	1400525.JNIU01000001_gene137	2.079e-109	373.0	COG0404@1|root,COG0404@2|Bacteria,1R3WG@1224|Proteobacteria,2U2ZT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the GcvT family	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
CMS3_k127_448777_19	1323663.AROI01000026_gene1885	1.734e-19	89.0	2DS3D@1|root,33EC4@2|Bacteria,1P2RI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_448777_18	1313172.YM304_14670	4.866e-28	115.0	2E6FA@1|root,3312Q@2|Bacteria,2GUWJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_448777_2	1211815.CBYP010000063_gene1892	5.64e-174	563.0	COG0526@1|root,COG0526@2|Bacteria,2IET9@201174|Actinobacteria	201174|Actinobacteria	CO	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_448777_7	1122609.AUGT01000023_gene576	3.812e-93	339.0	COG0028@1|root,COG0028@2|Bacteria,2GKGX@201174|Actinobacteria,4DUUR@85009|Propionibacteriales	201174|Actinobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_448777_23	1259795.ARJK01000003_gene1247	4.932e-11	69.0	COG0329@1|root,COG0329@2|Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.1.2.34	ko:K11949	ko00624,ko01120,map00624,map01120	-	R07713	RC00924,RC00936	ko00000,ko00001,ko01000	-	-	-	DHDPS
CMS3_k127_448777_14	1121324.CLIT_2c03230	7.554e-59	213.0	COG2998@1|root,COG2998@2|Bacteria,1V9V8@1239|Firmicutes,25H3U@186801|Clostridia	186801|Clostridia	H	Copper amine oxidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1
CMS3_k127_448777_6	408672.NBCG_04849	1.187e-104	346.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4DP52@85009|Propionibacteriales	201174|Actinobacteria	E	amino acid ABC transporter, ATP-binding protein	glnQ	-	3.6.3.21	ko:K02028,ko:K17076	ko02010,map02010	M00236,M00589	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.20	-	-	ABC_tran
CMS3_k127_448777_9	1122182.KB903835_gene4482	8.918e-84	287.0	COG0765@1|root,COG0765@2|Bacteria,2GM0I@201174|Actinobacteria,4DBWF@85008|Micromonosporales	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
CMS3_k127_448777_13	494419.ALPM01000029_gene3146	8.755e-60	219.0	COG0834@1|root,COG0834@2|Bacteria,2GJQW@201174|Actinobacteria,1W95W@1268|Micrococcaceae	201174|Actinobacteria	ET	Belongs to the bacterial solute-binding protein 3 family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
CMS3_k127_448777_22	1144275.COCOR_03122	3.779e-14	76.0	COG3832@1|root,COG5646@1|root,COG3832@2|Bacteria,COG5646@2|Bacteria,1NKMZ@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,DUF1801
CMS3_k127_448777_8	526225.Gobs_0019	9.371e-92	314.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
CMS3_k127_448777_1	1313172.YM304_03530	1.139e-195	632.0	COG3046@1|root,COG3046@2|Bacteria,2GMF6@201174|Actinobacteria,4CNN7@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Deoxyribodipyrimidine photo-lyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
CMS3_k127_448777_15	237368.SCABRO_02834	1.114e-53	195.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_448777_3	358823.DF19_14875	5.271e-158	503.0	COG1741@1|root,COG1741@2|Bacteria,2GIY9@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
CMS3_k127_448777_20	222534.KB893670_gene3715	1.063e-18	91.0	COG1846@1|root,COG1846@2|Bacteria,2IJHQ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator (MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
CMS3_k127_448777_17	1137269.AZWL01000005_gene2268	3.866e-36	153.0	COG4292@1|root,COG4292@2|Bacteria,2GJPB@201174|Actinobacteria	201174|Actinobacteria	S	Low temperature requirement	-	-	-	-	-	-	-	-	-	-	-	-	LtrA
CMS3_k127_448777_16	552811.Dehly_0581	9.345e-50	181.0	COG0221@1|root,COG0221@2|Bacteria,2G6T4@200795|Chloroflexi,34CZD@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
CMS3_k127_4512310_13	1313172.YM304_35680	5.454e-44	169.0	COG1414@1|root,COG1414@2|Bacteria,2HGKJ@201174|Actinobacteria,4CNIR@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix isocitrate lyase regulation	-	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
CMS3_k127_4512310_17	349124.Hhal_0081	3.718e-16	87.0	COG0704@1|root,COG0704@2|Bacteria,1NRGK@1224|Proteobacteria,1SMQP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	PhoU domain	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
CMS3_k127_4512310_6	1229780.BN381_150112	2.361e-103	348.0	COG1283@1|root,COG1283@2|Bacteria,2IAMX@201174|Actinobacteria	201174|Actinobacteria	P	Na+/Pi-cotransporter	nptA	-	-	ko:K03324,ko:K14683	-	-	-	-	ko00000,ko02000,ko04147	2.A.58.1,2.A.58.2	-	-	Na_Pi_cotrans
CMS3_k127_4512310_10	1157635.KB892011_gene1199	6.003e-59	215.0	COG3285@1|root,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase LigD polymerase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_primase_S
CMS3_k127_4512310_2	886293.Sinac_4708	2.073e-159	520.0	COG0281@1|root,COG0281@2|Bacteria,2J0KC@203682|Planctomycetes	203682|Planctomycetes	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT_4,Malic_M,malic
CMS3_k127_4512310_8	1120934.KB894410_gene6848	2.524e-81	278.0	COG2120@1|root,COG2120@2|Bacteria,2GIUS@201174|Actinobacteria,4DZX7@85010|Pseudonocardiales	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS3_k127_4512310_5	219305.MCAG_04658	2.386e-117	390.0	COG2327@1|root,COG2327@2|Bacteria,2H256@201174|Actinobacteria,4DHFQ@85008|Micromonosporales	201174|Actinobacteria	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
CMS3_k127_4512310_1	1120959.ATXF01000009_gene798	6.339e-189	610.0	COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria,4FRFT@85023|Microbacteriaceae	201174|Actinobacteria	I	Acetyl-CoA dehydrogenase C-terminal like	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
CMS3_k127_4512310_12	2074.JNYD01000014_gene7070	2.716e-48	186.0	COG1295@1|root,COG1295@2|Bacteria,2GM6P@201174|Actinobacteria,4E0J5@85010|Pseudonocardiales	201174|Actinobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
CMS3_k127_4512310_3	1229780.BN381_80340	7.011e-129	423.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,3UW8N@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
CMS3_k127_4512310_11	1128421.JAGA01000001_gene2135	1.429e-53	194.0	COG0652@1|root,COG0652@2|Bacteria,2NPSW@2323|unclassified Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.11.1,5.2.1.8	ko:K01802,ko:K03767,ko:K03768,ko:K12132	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03110,ko04147	-	-	-	Pro_isomerase
CMS3_k127_4512310_9	479434.Sthe_0511	1.891e-68	249.0	COG1306@1|root,COG1306@2|Bacteria,2G81Y@200795|Chloroflexi,27XJ9@189775|Thermomicrobia	189775|Thermomicrobia	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF4015
CMS3_k127_4512310_16	1121365.AQXB01000004_gene2007	4.82e-17	84.0	2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,22NJY@1653|Corynebacteriaceae	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB2	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
CMS3_k127_4512310_0	644283.Micau_2391	1.77e-203	662.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4DIFC@85008|Micromonosporales	201174|Actinobacteria	G	PEP-utilising enzyme, mobile domain	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS3_k127_4512310_14	266940.Krad_0259	1.231e-31	134.0	291ZT@1|root,2ZPJ4@2|Bacteria,2GR7R@201174|Actinobacteria	201174|Actinobacteria	S	regulation of cellular protein catabolic process	bpa	GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369	-	-	-	-	-	-	-	-	-	-	DUF2587
CMS3_k127_4512310_4	644283.Micau_5428	1.794e-125	421.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4D8HC@85008|Micromonosporales	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
CMS3_k127_4512310_15	926550.CLDAP_13740	1.86e-22	105.0	2DRD4@1|root,33B9X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4512310_7	926550.CLDAP_13750	1.093e-97	334.0	COG1404@1|root,COG1404@2|Bacteria,2G7GP@200795|Chloroflexi	200795|Chloroflexi	M	LPXTG-motif cell wall anchor domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
CMS3_k127_4517757_17	1385510.N781_02185	5.496e-22	103.0	2CYAI@1|root,32T3W@2|Bacteria,1U9TU@1239|Firmicutes,4IK18@91061|Bacilli,2YBKS@289201|Pontibacillus	91061|Bacilli	S	Electron transfer DM13	-	-	-	-	-	-	-	-	-	-	-	-	DM13
CMS3_k127_4517757_1	1121441.AUCX01000007_gene1090	1.216e-186	589.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2MA8W@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	kbl	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2,BioW
CMS3_k127_4517757_3	1121456.ATVA01000011_gene1386	1.404e-152	489.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PCA@68525|delta/epsilon subdivisions,2WM39@28221|Deltaproteobacteria,2MGBC@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_4517757_12	1313172.YM304_41870	3.531e-36	141.0	2DMMQ@1|root,32SHK@2|Bacteria,2IHWW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3052
CMS3_k127_4517757_18	639282.DEFDS_1750	9.883e-19	88.0	COG0361@1|root,COG0361@2|Bacteria,2GFTE@200930|Deferribacteres	200930|Deferribacteres	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
CMS3_k127_4517757_14	479433.Caci_7704	9.488e-29	122.0	COG5516@1|root,COG5516@2|Bacteria,2GJZN@201174|Actinobacteria	201174|Actinobacteria	S	CGNR zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
CMS3_k127_4517757_15	926560.KE387023_gene3156	2.593e-28	124.0	COG3369@1|root,COG3592@1|root,COG3369@2|Bacteria,COG3592@2|Bacteria,1WMWX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Divergent 4Fe-4S mono-cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_19,zf-CDGSH
CMS3_k127_4517757_2	266835.14025264	1.353e-154	503.0	COG5598@1|root,COG5598@2|Bacteria,1N18H@1224|Proteobacteria,2TRUE@28211|Alphaproteobacteria,43IVD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	mttB2	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
CMS3_k127_4517757_19	485913.Krac_8724	5.524e-18	91.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS3_k127_4517757_20	2002.JOEQ01000020_gene7074	7.332e-16	81.0	2E7QZ@1|root,3326A@2|Bacteria,2GR1A@201174|Actinobacteria,4EKGI@85012|Streptosporangiales	201174|Actinobacteria	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
CMS3_k127_4517757_6	926550.CLDAP_01830	9.665e-135	436.0	COG1071@1|root,COG1071@2|Bacteria,2G6HY@200795|Chloroflexi	200795|Chloroflexi	C	PFAM dehydrogenase, E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
CMS3_k127_4517757_4	926550.CLDAP_01840	6.463e-147	472.0	COG0022@1|root,COG0022@2|Bacteria,2G5JU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Transketolase central region	-	-	-	-	-	-	-	-	-	-	-	-	Transket_pyr,Transketolase_C
CMS3_k127_4517757_10	2002.JOEQ01000012_gene5606	5.621e-38	153.0	COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria,4EQYN@85012|Streptosporangiales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_4517757_0	502025.Hoch_3456	3.696e-222	710.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MQS@68525|delta/epsilon subdivisions,2WINP@28221|Deltaproteobacteria,2YU7W@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	fadJ	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
CMS3_k127_4517757_5	1144275.COCOR_02197	4.466e-144	478.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42N7F@68525|delta/epsilon subdivisions,2WJB2@28221|Deltaproteobacteria,2YUH3@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the thiolase family	fadI	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_4517757_16	263358.VAB18032_23810	1.364e-24	121.0	2C72U@1|root,32W8F@2|Bacteria,2GTSA@201174|Actinobacteria,4DG1X@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4517757_13	1337093.MBE-LCI_0637	2.403e-31	141.0	COG0477@1|root,COG2814@2|Bacteria,1MX2Q@1224|Proteobacteria,2TRNS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_4517757_9	375286.mma_0137	1.182e-65	241.0	COG1225@1|root,COG1225@2|Bacteria,1MWJP@1224|Proteobacteria,2VQ0B@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Redoxin	bcpB	-	-	-	-	-	-	-	-	-	-	-	Redoxin
CMS3_k127_4517757_11	351607.Acel_0489	6.249e-38	159.0	COG0500@1|root,COG0500@2|Bacteria,2I305@201174|Actinobacteria,4EXEX@85013|Frankiales	201174|Actinobacteria	Q	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_4517757_7	1380393.JHVP01000001_gene2445	6.134e-101	339.0	COG1793@1|root,COG1793@2|Bacteria,2I2EA@201174|Actinobacteria,4ERYT@85013|Frankiales	201174|Actinobacteria	L	DNA ligase	ligC	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
CMS3_k127_4517757_8	469383.Cwoe_3833	1.234e-96	326.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4CS2X@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA primase, small subunit	-	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
CMS3_k127_4537066_4	1313172.YM304_06520	3.566e-42	158.0	COG3153@1|root,COG3153@2|Bacteria,2IKX0@201174|Actinobacteria	201174|Actinobacteria	Q	acetyltransferase	-	-	-	ko:K03824	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_9
CMS3_k127_4537066_7	326427.Cagg_1682	9.304e-23	100.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	MA20_23570	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_34
CMS3_k127_4537066_0	635013.TherJR_0239	1.586e-198	638.0	COG1032@1|root,COG1032@2|Bacteria,1UZQC@1239|Firmicutes,24PDA@186801|Clostridia	186801|Clostridia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS3_k127_4537066_5	1123366.TH3_17749	1.948e-33	138.0	COG1247@1|root,COG1247@2|Bacteria,1RDHN@1224|Proteobacteria,2U98I@28211|Alphaproteobacteria,2JSWH@204441|Rhodospirillales	204441|Rhodospirillales	M	COG1247 Sortase and related acyltransferases	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
CMS3_k127_4537066_1	1382306.JNIM01000001_gene1030	2.196e-172	554.0	COG2873@1|root,COG2873@2|Bacteria,2G5NS@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	CoA_binding_2,Cys_Met_Meta_PP
CMS3_k127_4537066_3	926564.KI911756_gene6012	5.845e-56	199.0	COG1832@1|root,COG1832@2|Bacteria,2IHSP@201174|Actinobacteria,4F5WT@85017|Promicromonosporaceae	201174|Actinobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
CMS3_k127_4537066_6	105425.BBPL01000051_gene5767	3.632e-31	134.0	COG2755@1|root,COG2755@2|Bacteria,2IC8X@201174|Actinobacteria,2NGHK@228398|Streptacidiphilus	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS3_k127_4537066_2	1547437.LL06_20730	7.288e-69	246.0	COG1744@1|root,COG1744@2|Bacteria,1NGHH@1224|Proteobacteria,2TR36@28211|Alphaproteobacteria,43GX8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	ABC-type transport system, periplasmic component surface lipoprotein	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
CMS3_k127_4537656_5	28444.JODQ01000008_gene966	0.0002378	45.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4EI2I@85012|Streptosporangiales	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
CMS3_k127_4537656_0	1313172.YM304_30950	8.414e-236	740.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4CMVZ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
CMS3_k127_4537656_3	1313172.YM304_30950	2.534e-26	109.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4CMVZ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
CMS3_k127_4537656_2	1394178.AWOO02000093_gene8064	4.573e-32	141.0	COG1404@1|root,COG1404@2|Bacteria,2GNIX@201174|Actinobacteria,4EIJI@85012|Streptosporangiales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS3_k127_4537656_1	1380370.JIBA01000015_gene98	6.432e-102	366.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4FE8Z@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_12
CMS3_k127_4537656_4	1348114.OM33_20185	1.822e-07	61.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria,2Q1A2@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_16,TPR_19,TPR_20,TPR_8
CMS3_k127_4557824_5	1410665.JNKR01000004_gene1468	8.666e-49	179.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,4H271@909932|Negativicutes	909932|Negativicutes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
CMS3_k127_4557824_3	521098.Aaci_2780	8.281e-115	380.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,4H9MB@91061|Bacilli,27865@186823|Alicyclobacillaceae	91061|Bacilli	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CMS3_k127_4557824_6	1297742.A176_01908	6.939e-47	179.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WNH0@28221|Deltaproteobacteria,2YVC9@29|Myxococcales	28221|Deltaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
CMS3_k127_4557824_8	67257.JODR01000008_gene3437	7.761e-36	144.0	COG0009@1|root,COG0009@2|Bacteria,2GK2X@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the SUA5 family	ywlC	GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
CMS3_k127_4557824_14	557599.MKAN_28615	4.304e-12	78.0	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria,235HD@1762|Mycobacteriaceae	201174|Actinobacteria	L	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,PD40,TIR_2,WD40
CMS3_k127_4557824_2	644966.Tmar_0757	3.658e-148	484.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,3WCFT@538999|Clostridiales incertae sedis	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
CMS3_k127_4557824_7	1229780.BN381_10042	1.594e-42	166.0	COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria,3UWN7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
CMS3_k127_4557824_12	443906.CMM_1164	1.286e-21	95.0	COG0636@1|root,COG0636@2|Bacteria,2GQI6@201174|Actinobacteria,4FPGX@85023|Microbacteriaceae	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
CMS3_k127_4557824_11	1157634.KB912967_gene931	2.369e-25	114.0	COG0711@1|root,COG0711@2|Bacteria,2GJS4@201174|Actinobacteria	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
CMS3_k127_4557824_10	1313172.YM304_10630	1.842e-30	126.0	COG0712@1|root,COG0712@2|Bacteria,2HGFG@201174|Actinobacteria,4CND3@84992|Acidimicrobiia	84992|Acidimicrobiia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
CMS3_k127_4557824_1	1313172.YM304_10640	7.735e-205	648.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4CMTI@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
CMS3_k127_4557824_4	635013.TherJR_2888	2.226e-68	242.0	COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia,2601T@186807|Peptococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
CMS3_k127_4557824_0	525909.Afer_1795	1.727e-213	672.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4CMWB@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
CMS3_k127_4557824_13	675635.Psed_1686	1.078e-15	88.0	COG0355@1|root,COG0355@2|Bacteria,2IHNZ@201174|Actinobacteria,4E4C5@85010|Pseudonocardiales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
CMS3_k127_4557824_9	371731.Rsw2DRAFT_1386	1.31e-33	141.0	COG0697@1|root,COG0697@2|Bacteria,1RFZW@1224|Proteobacteria,2TRXD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_4609478_2	1032480.MLP_34170	8.652e-10	61.0	COG1848@1|root,COG1848@2|Bacteria,2HMSG@201174|Actinobacteria,4DVFP@85009|Propionibacteriales	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4609478_1	1122135.KB893135_gene653	1.821e-57	204.0	COG0346@1|root,COG0346@2|Bacteria,1N4SE@1224|Proteobacteria,2UDXY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_4609478_0	1403819.BATR01000022_gene806	1.217e-127	426.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,46TZ3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,NB-ARC
CMS3_k127_4693722_0	450851.PHZ_c0252	3.908e-180	575.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,2KEZN@204458|Caulobacterales	204458|Caulobacterales	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_4693722_11	1380390.JIAT01000011_gene2335	1.172e-60	216.0	COG2197@1|root,COG2197@2|Bacteria,2IIDD@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_4693722_17	298654.FraEuI1c_6801	3.578e-25	109.0	COG2197@1|root,COG2197@2|Bacteria,2INZX@201174|Actinobacteria,4EW4I@85013|Frankiales	201174|Actinobacteria	T	PFAM response regulator receiver	-	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
CMS3_k127_4693722_8	1246995.AFR_16250	2.541e-69	262.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2I8X1@201174|Actinobacteria,4DH0K@85008|Micromonosporales	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HisKA_3
CMS3_k127_4693722_12	298655.KI912266_gene533	9.359e-60	232.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2I8X1@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HisKA_3
CMS3_k127_4693722_2	1380356.JNIK01000014_gene3473	6.819e-154	497.0	COG2114@1|root,COG2197@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,2GJRI@201174|Actinobacteria,4EU4G@85013|Frankiales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
CMS3_k127_4693722_14	1210046.B277_08255	2.094e-36	146.0	2EG29@1|root,339U9@2|Bacteria,2GPUY@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (Hypoth_ymh)	-	-	-	-	-	-	-	-	-	-	-	-	Hypoth_Ymh
CMS3_k127_4693722_20	1122182.KB903821_gene1310	5.157e-22	108.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,2GJB4@201174|Actinobacteria,4DM4Z@85008|Micromonosporales	201174|Actinobacteria	CE	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
CMS3_k127_4693722_13	479433.Caci_7341	1.5e-38	164.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	1.14.14.5	ko:K04091	ko00920,map00920	-	R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
CMS3_k127_4693722_4	215803.DB30_8503	9.128e-133	443.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M0V@68525|delta/epsilon subdivisions,2WIQ1@28221|Deltaproteobacteria,2YXMX@29|Myxococcales	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	larD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_3245	FAD-oxidase_C,FAD_binding_4
CMS3_k127_4693722_7	1229780.BN381_10208	1.112e-80	282.0	COG0263@1|root,COG0263@2|Bacteria,2GM8U@201174|Actinobacteria,3UWHH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
CMS3_k127_4693722_5	526225.Gobs_1590	6.756e-101	343.0	COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,4ES3D@85013|Frankiales	201174|Actinobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
CMS3_k127_4693722_15	1313172.YM304_18470	4.723e-27	111.0	COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4CN91@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal L27 protein	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
CMS3_k127_4693722_16	767029.HMPREF9154_1825	6.502e-27	119.0	COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria,4DRJ6@85009|Propionibacteriales	201174|Actinobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
CMS3_k127_4693722_3	1449058.JQKT01000007_gene1282	1.152e-146	482.0	COG1530@1|root,COG1530@2|Bacteria,2GMM5@201174|Actinobacteria,4FM45@85023|Microbacteriaceae	201174|Actinobacteria	J	Ribonuclease E/G family	rne	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	IF2_N,RNase_E_G,S1
CMS3_k127_4693722_10	1340493.JNIF01000004_gene501	4.661e-64	225.0	COG1435@1|root,COG1435@2|Bacteria,3Y4XG@57723|Acidobacteria	57723|Acidobacteria	F	PFAM Thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
CMS3_k127_4693722_9	110319.CF8_1100	7.211e-68	252.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4DN3V@85009|Propionibacteriales	201174|Actinobacteria	D	Cell cycle protein	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
CMS3_k127_4693722_6	1121866.AUGK01000011_gene535	3.861e-97	344.0	COG0768@1|root,COG0768@2|Bacteria,2GJ61@201174|Actinobacteria,4CUTW@84998|Coriobacteriia	84998|Coriobacteriia	M	Penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
CMS3_k127_4693722_22	408672.NBCG_02197	9.203e-07	57.0	COG2891@1|root,COG2891@2|Bacteria,2GN0I@201174|Actinobacteria,4DRR5@85009|Propionibacteriales	201174|Actinobacteria	M	rod shape-determining protein (MreD)	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
CMS3_k127_4693722_19	566461.SSFG_04763	2.264e-24	114.0	COG1792@1|root,COG1792@2|Bacteria,2GJN0@201174|Actinobacteria	201174|Actinobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
CMS3_k127_4693722_1	298654.FraEuI1c_1957	1.201e-154	497.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4ES3S@85013|Frankiales	201174|Actinobacteria	D	TIGRFAM Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
CMS3_k127_4693722_18	404380.Gbem_2532	4.098e-25	109.0	2DFV1@1|root,2ZT9B@2|Bacteria	2|Bacteria	S	Alkylmercury lyase	-	-	-	-	-	-	-	-	-	-	-	-	MerB
CMS3_k127_4693722_21	404380.Gbem_2532	7.24e-17	81.0	2DFV1@1|root,2ZT9B@2|Bacteria	2|Bacteria	S	Alkylmercury lyase	-	-	-	-	-	-	-	-	-	-	-	-	MerB
CMS3_k127_4695343_1	479432.Sros_3854	3.34e-183	578.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,4ENHD@85012|Streptosporangiales	201174|Actinobacteria	E	GMC oxidoreductase	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
CMS3_k127_4695343_12	521674.Plim_1587	1.192e-24	107.0	COG0724@1|root,COG0724@2|Bacteria,2IZPY@203682|Planctomycetes	203682|Planctomycetes	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS3_k127_4695343_7	760011.Spico_1294	1.225e-53	205.0	COG0634@1|root,COG0634@2|Bacteria,2J8PE@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
CMS3_k127_4695343_13	1114959.SZMC14600_09898	5.736e-19	89.0	COG0491@1|root,COG0491@2|Bacteria,2HJB4@201174|Actinobacteria,4E04N@85010|Pseudonocardiales	201174|Actinobacteria	S	Zn-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_4695343_11	595593.JREV01000005_gene2977	5.451e-25	111.0	COG1186@1|root,COG1186@2|Bacteria,2IFEJ@201174|Actinobacteria,1W95H@1268|Micrococcaceae	201174|Actinobacteria	J	RF-1 domain	yaeJ	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
CMS3_k127_4695343_0	285535.JOEY01000105_gene5505	4.001e-267	838.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria	201174|Actinobacteria	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	ko:K21833	-	-	-	-	ko00000	-	-	-	NAD_binding_8,Oxidored_FMN,Pyr_redox_2
CMS3_k127_4695343_9	928724.SacglDRAFT_02507	6.588e-37	150.0	COG0730@1|root,COG0730@2|Bacteria,2IIY7@201174|Actinobacteria,4E3NW@85010|Pseudonocardiales	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS3_k127_4695343_5	1313172.YM304_38950	1.727e-113	381.0	COG2733@1|root,COG2733@2|Bacteria,2GKGM@201174|Actinobacteria	201174|Actinobacteria	M	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
CMS3_k127_4695343_6	1128421.JAGA01000003_gene3248	4.672e-64	235.0	COG0477@1|root,COG2814@2|Bacteria,2NQ08@2323|unclassified Bacteria	2|Bacteria	EGP	MFS_1 like family	-	-	-	ko:K08151,ko:K08153	-	M00668,M00717	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75,2.A.1.2.8	-	-	MFS_1,MFS_1_like,Sugar_tr
CMS3_k127_4695343_8	384765.SIAM614_17214	3.991e-37	151.0	COG3743@1|root,COG3743@2|Bacteria,1RA3K@1224|Proteobacteria,2U7GQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4332)	MA20_15755	-	-	-	-	-	-	-	-	-	-	-	DUF4332
CMS3_k127_4695343_10	1313172.YM304_13550	6.432e-35	141.0	COG2259@1|root,COG2259@2|Bacteria,2IQ5C@201174|Actinobacteria	201174|Actinobacteria	S	DoxX family	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
CMS3_k127_4695343_3	1298864.AUEQ01000003_gene5714	7.554e-150	489.0	COG1793@1|root,COG1793@2|Bacteria,2GJ2P@201174|Actinobacteria,235KI@1762|Mycobacteriaceae	201174|Actinobacteria	F	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
CMS3_k127_4695343_14	1288079.AUKN01000003_gene3543	1.6e-09	64.0	299KI@1|root,2ZWNZ@2|Bacteria,2IT8K@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4695343_2	1121403.AUCV01000065_gene4170	4.308e-161	525.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,42M9Y@68525|delta/epsilon subdivisions,2X5IZ@28221|Deltaproteobacteria,2MPF3@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
CMS3_k127_4695343_4	1120950.KB892785_gene223	2.948e-131	423.0	COG1960@1|root,COG1960@2|Bacteria,2GMEM@201174|Actinobacteria,4DNK5@85009|Propionibacteriales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	fadE19	GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681	1.3.8.1,1.3.99.12	ko:K00248,ko:K11410	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_472514_0	234267.Acid_5749	2.031e-94	319.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
CMS3_k127_472514_1	1267533.KB906733_gene3215	6.689e-69	257.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
CMS3_k127_4729071_8	1869.MB27_03395	3.014e-31	128.0	COG1522@1|root,COG1522@2|Bacteria,2GP1P@201174|Actinobacteria,4DBHK@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
CMS3_k127_4729071_4	1313172.YM304_16810	2.652e-98	332.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.82	ko:K18815	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
CMS3_k127_4729071_7	926550.CLDAP_13130	4.615e-57	207.0	COG3153@1|root,COG3153@2|Bacteria,2G8MF@200795|Chloroflexi	200795|Chloroflexi	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_4729071_2	1380347.JNII01000008_gene4085	1.802e-114	383.0	COG0687@1|root,COG0687@2|Bacteria,2GKVG@201174|Actinobacteria,4ESHI@85013|Frankiales	201174|Actinobacteria	E	PFAM extracellular solute-binding protein family 1	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_6,SBP_bac_8
CMS3_k127_4729071_1	469383.Cwoe_4279	1.323e-125	413.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4CRCY@84995|Rubrobacteria	84995|Rubrobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
CMS3_k127_4729071_3	1380347.JNII01000008_gene4083	1.124e-107	357.0	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria,4ET85@85013|Frankiales	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	potB	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
CMS3_k127_4729071_5	1380347.JNII01000008_gene4082	6.128e-95	317.0	COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria,4ESYW@85013|Frankiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
CMS3_k127_4729071_0	215803.DB30_7204	1.024e-278	878.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,42YZ6@68525|delta/epsilon subdivisions,2WU2X@28221|Deltaproteobacteria,2YXQD@29|Myxococcales	28221|Deltaproteobacteria	E	FAD dependent oxidoreductase central domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
CMS3_k127_4729071_9	1957.JODX01000003_gene4756	2.393e-10	72.0	2DPU0@1|root,333DA@2|Bacteria,2GNE1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LppX_LprAFG
CMS3_k127_4729071_6	1380600.AUYN01000001_gene2907	2.178e-63	230.0	28JUF@1|root,2Z9JH@2|Bacteria,4NHS3@976|Bacteroidetes,1HYHH@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RskA
CMS3_k127_4729071_10	406818.XBJ1_3704	4.155e-09	62.0	2DRA2@1|root,33AVQ@2|Bacteria,1NKZA@1224|Proteobacteria,1SH2Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4767586_1	479434.Sthe_1438	3.069e-299	945.0	COG0495@1|root,COG0495@2|Bacteria,2G5MX@200795|Chloroflexi,27XYD@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
CMS3_k127_4767586_8	479431.Namu_0440	7.373e-17	89.0	COG1876@1|root,COG1876@2|Bacteria,2IS17@201174|Actinobacteria,4EX4K@85013|Frankiales	201174|Actinobacteria	M	PFAM peptidase M15B and M15C DD-carboxypeptidase VanY endolysin	-	-	-	-	-	-	-	-	-	-	-	-	VanY
CMS3_k127_4767586_7	1123023.JIAI01000007_gene1963	4.092e-21	100.0	COG0404@1|root,COG0446@1|root,COG4583@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,COG4583@2|Bacteria,2GMBK@201174|Actinobacteria,4E081@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the GcvT family	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
CMS3_k127_4767586_0	1123024.AUII01000011_gene4455	0.0	1182.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,2GMBK@201174|Actinobacteria,4E081@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the GcvT family	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
CMS3_k127_4767586_6	1123024.AUII01000011_gene4456	1.873e-26	110.0	COG4311@1|root,COG4311@2|Bacteria,2GVD9@201174|Actinobacteria	201174|Actinobacteria	E	Sarcosine oxidase, delta subunit family	-	-	1.5.3.1	ko:K00304	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxD
CMS3_k127_4767586_2	1123023.JIAI01000007_gene1965	7.441e-207	649.0	COG0665@1|root,COG0665@2|Bacteria,2GNAE@201174|Actinobacteria,4EEMB@85010|Pseudonocardiales	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
CMS3_k127_4767586_3	1265505.ATUG01000001_gene3190	2.717e-152	492.0	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAO
CMS3_k127_4767586_9	349163.Acry_2562	1.588e-13	81.0	2EFVH@1|root,339MR@2|Bacteria,1NQE9@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4767586_5	1121930.AQXG01000006_gene791	3.132e-59	217.0	COG0615@1|root,COG0615@2|Bacteria,4NY73@976|Bacteroidetes,1IUPI@117747|Sphingobacteriia	976|Bacteroidetes	IM	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
CMS3_k127_4767586_4	1536775.H70737_27840	2.385e-65	231.0	COG0463@1|root,COG0463@2|Bacteria,1TPR3@1239|Firmicutes,4HC2Z@91061|Bacilli,26RTV@186822|Paenibacillaceae	91061|Bacilli	M	Glycosyl transferase family 2	arnC	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
CMS3_k127_4773983_0	1313172.YM304_01060	2.707e-163	522.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CMTJ@84992|Acidimicrobiia	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_4773983_4	351607.Acel_0016	1.026e-34	143.0	COG3764@1|root,COG3764@2|Bacteria,2GKT6@201174|Actinobacteria,4ESQZ@85013|Frankiales	201174|Actinobacteria	M	PFAM peptidase C60, sortase A and B	srtB	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
CMS3_k127_4773983_3	479434.Sthe_1877	4.823e-66	230.0	COG0512@1|root,COG0512@2|Bacteria,2G69G@200795|Chloroflexi,27Y8S@189775|Thermomicrobia	189775|Thermomicrobia	EH	Peptidase C26	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
CMS3_k127_4773983_1	1313172.YM304_02120	1.299e-116	403.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4CMUZ@84992|Acidimicrobiia	84992|Acidimicrobiia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS3_k127_4773983_2	590998.Celf_0031	2.146e-72	254.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,4F0UK@85016|Cellulomonadaceae	201174|Actinobacteria	M	Penicillin binding protein transpeptidase domain	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
CMS3_k127_4790755_0	479435.Kfla_6667	2.426e-31	130.0	COG1595@1|root,COG1595@2|Bacteria,2IRNG@201174|Actinobacteria,4DRJR@85009|Propionibacteriales	201174|Actinobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_480333_1	338966.Ppro_0746	4.325e-56	204.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2WIZZ@28221|Deltaproteobacteria,43T1T@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
CMS3_k127_480333_2	1245475.ANAE01000163_gene1729	1.556e-42	171.0	COG5479@1|root,COG5479@2|Bacteria,2GMJR@201174|Actinobacteria,4EJ9Y@85012|Streptosporangiales	201174|Actinobacteria	M	Protein of unknown function (DUF3152)	peg3	-	-	-	-	-	-	-	-	-	-	-	DUF3152
CMS3_k127_480333_0	1313172.YM304_09930	5.234e-82	283.0	28TMF@1|root,2ZFV1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_480333_4	1227453.C444_17607	1.493e-06	56.0	COG2141@1|root,arCOG02410@2157|Archaea,2XT6F@28890|Euryarchaeota,23TX5@183963|Halobacteria	183963|Halobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_4835818_9	195250.CM001776_gene2489	2.426e-93	311.0	COG0276@1|root,COG0276@2|Bacteria,1G0H9@1117|Cyanobacteria,1GZVE@1129|Synechococcus	1117|Cyanobacteria	H	Belongs to the ferrochelatase family	-	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
CMS3_k127_4835818_22	494419.ALPM01000063_gene2257	0.0004874	46.0	COG0596@1|root,COG0596@2|Bacteria,2GJ4I@201174|Actinobacteria,1WA0N@1268|Micrococcaceae	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
CMS3_k127_4835818_19	1123234.AUKI01000019_gene486	8.451e-21	100.0	COG2335@1|root,COG2335@2|Bacteria,4NVI8@976|Bacteroidetes,1I598@117743|Flavobacteriia	976|Bacteroidetes	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
CMS3_k127_4835818_18	1449351.RISW2_11890	8.513e-22	103.0	COG1309@1|root,COG1309@2|Bacteria,1RE7W@1224|Proteobacteria,2U8AN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_4835818_14	393305.YE2492	1.632e-58	211.0	COG1136@1|root,COG1136@2|Bacteria,1Q3QX@1224|Proteobacteria,1RQIZ@1236|Gammaproteobacteria,41E8V@629|Yersinia	1236|Gammaproteobacteria	V	ATPases associated with a variety of cellular activities	macB_2	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_4835818_3	1394178.AWOO02000044_gene4477	8.124e-197	640.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_4835818_12	391625.PPSIR1_18797	8.05e-67	236.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
CMS3_k127_4835818_0	1121935.AQXX01000115_gene4993	0.0	1034.0	COG2866@1|root,COG4412@1|root,COG2866@2|Bacteria,COG4412@2|Bacteria,1MZYN@1224|Proteobacteria,1RXX1@1236|Gammaproteobacteria,1XQQE@135619|Oceanospirillales	135619|Oceanospirillales	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14,Peptidase_M6
CMS3_k127_4835818_17	479431.Namu_0508	1.107e-51	196.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	CP_0620	-	3.1.3.5,3.6.1.45	ko:K06889,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Abhydrolase_1,DLH,Hydrolase_4,Metallophos,Peptidase_S9,SLH
CMS3_k127_4835818_16	258533.BN977_03935	1.848e-52	192.0	COG0778@1|root,COG0778@2|Bacteria,2GW57@201174|Actinobacteria,2374Z@1762|Mycobacteriaceae	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS3_k127_4835818_6	861299.J421_1756	1.345e-140	462.0	COG0624@1|root,COG0624@2|Bacteria,1ZUA4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_4835818_5	1232429.CBLL010000048_gene1806	9.677e-146	468.0	COG0620@1|root,COG0620@2|Bacteria,2GIXA@201174|Actinobacteria,1W81R@1268|Micrococcaceae	201174|Actinobacteria	E	Cobalamin-independent synthase, Catalytic domain	metE	-	2.1.1.14,4.4.1.23	ko:K00549,ko:K22363	ko00270,ko00450,ko00625,ko01100,ko01110,ko01230,map00270,map00450,map00625,map01100,map01110,map01230	M00017	R04405,R09365,R11897,R11899	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
CMS3_k127_4835818_10	1169152.AXVD01000023_gene3256	2.341e-89	305.0	COG2021@1|root,COG2021@2|Bacteria,2HIEG@201174|Actinobacteria,4G3VG@85025|Nocardiaceae	201174|Actinobacteria	E	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_4835818_2	909663.KI867150_gene97	3.546e-216	690.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MQ8Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
CMS3_k127_4835818_1	555779.Dthio_PD3239	7.305e-264	833.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
CMS3_k127_4835818_8	903818.KI912268_gene1657	5.97e-97	326.0	COG2069@1|root,COG2069@2|Bacteria	2|Bacteria	C	one-carbon metabolic process	acsD	-	1.2.7.4,2.1.1.245	ko:K00194,ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R07157,R08034,R09096,R10219,R10243	RC00004,RC00113,RC00250,RC02800,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,MTHFR
CMS3_k127_4835818_7	429009.Adeg_0337	6.753e-121	403.0	COG1456@1|root,COG1456@2|Bacteria,1TPWJ@1239|Firmicutes,24CTU@186801|Clostridia,42EP5@68295|Thermoanaerobacterales	186801|Clostridia	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	acsC	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
CMS3_k127_4835818_4	1009370.ALO_06363	1.097e-160	527.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,4H3SW@909932|Negativicutes	909932|Negativicutes	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
CMS3_k127_4835818_15	555779.Dthio_PD3223	4.655e-54	201.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42Q13@68525|delta/epsilon subdivisions,2WIT3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM dihydropteroate synthase, DHPS	-	-	2.1.1.258	ko:K15023	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R02289,R10243	RC00004,RC00113,RC01144,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CMS3_k127_4835818_20	314271.RB2654_18223	1.136e-18	100.0	COG0685@1|root,COG0685@2|Bacteria,1RHDY@1224|Proteobacteria,2U4I0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR_C
CMS3_k127_4835818_11	429009.Adeg_0345	1.184e-77	279.0	COG0685@1|root,COG0685@2|Bacteria,1UHX4@1239|Firmicutes,25E62@186801|Clostridia,42FH6@68295|Thermoanaerobacterales	186801|Clostridia	C	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
CMS3_k127_4835818_13	555779.Dthio_PD3224	1.409e-60	213.0	COG3640@1|root,COG3640@2|Bacteria,1RB02@1224|Proteobacteria,42NBP@68525|delta/epsilon subdivisions,2WKS7@28221|Deltaproteobacteria,2MEWX@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	Cellulose biosynthesis protein BcsQ	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
CMS3_k127_4849838_10	526225.Gobs_4168	0.0002708	49.0	2DKVQ@1|root,30HQN@2|Bacteria,2GPA0@201174|Actinobacteria,4EWA0@85013|Frankiales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_4
CMS3_k127_4849838_2	1445613.JALM01000094_gene3780	1.117e-122	401.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4E9T9@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_4849838_6	471852.Tcur_1528	3.63e-59	225.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,4EI7Y@85012|Streptosporangiales	201174|Actinobacteria	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
CMS3_k127_4849838_5	945713.IALB_1708	1.257e-75	259.0	COG0740@1|root,COG0740@2|Bacteria	2|Bacteria	OU	serine-type endopeptidase activity	clpP	GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0006355,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019538,GO:0030163,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051603,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
CMS3_k127_4849838_0	2002.JOEQ01000021_gene6733	3.018e-202	636.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,4EI0M@85012|Streptosporangiales	201174|Actinobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
CMS3_k127_4849838_8	419947.MRA_2312	4.132e-51	187.0	COG3196@1|root,COG3196@2|Bacteria,2IJUG@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterised protein family (UPF0167)	-	GO:0002682,GO:0002683,GO:0008150,GO:0009605,GO:0009607,GO:0031347,GO:0031348,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0065007,GO:0075136,GO:0080134	-	ko:K09925	-	-	-	-	ko00000	-	-	-	UPF0167
CMS3_k127_4849838_3	1120934.KB894408_gene4666	2.417e-90	306.0	COG2843@1|root,COG2843@2|Bacteria,2GP72@201174|Actinobacteria,4E1BJ@85010|Pseudonocardiales	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
CMS3_k127_4849838_7	1273125.Rrhod_0910	8.343e-55	213.0	COG2268@1|root,COG2268@2|Bacteria,2GK9I@201174|Actinobacteria,4FYES@85025|Nocardiaceae	201174|Actinobacteria	S	Flotillin	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
CMS3_k127_4849838_9	679197.HMPREF9336_01964	9.533e-09	64.0	2EPUV@1|root,33HFB@2|Bacteria,2ISBN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
CMS3_k127_4849838_1	1449976.KALB_2089	1.313e-136	446.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4E1ST@85010|Pseudonocardiales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_4849838_4	338963.Pcar_2315	2.783e-80	270.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,43S3P@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Valyl tRNA synthetase tRNA binding arm	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
CMS3_k127_4885353_2	1048339.KB913029_gene4945	4.137e-91	321.0	COG0668@1|root,COG0668@2|Bacteria,2GMFK@201174|Actinobacteria,4ES6X@85013|Frankiales	201174|Actinobacteria	M	mechanosensitive ion channel	mscS	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
CMS3_k127_4885353_3	1229780.BN381_60027	4.659e-61	217.0	COG1335@1|root,COG1335@2|Bacteria,2IFQW@201174|Actinobacteria,3UWWF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	Q	Isochorismatase family	pncA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
CMS3_k127_4885353_0	1521187.JPIM01000123_gene3604	4.983e-193	616.0	COG1488@1|root,COG1488@2|Bacteria,2G8NC@200795|Chloroflexi,376TD@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
CMS3_k127_4885353_4	298653.Franean1_4337	4.542e-34	138.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_4885353_1	215803.DB30_1702	7.405e-123	404.0	COG1611@1|root,COG1611@2|Bacteria,1R7TB@1224|Proteobacteria,43F31@68525|delta/epsilon subdivisions,2X36V@28221|Deltaproteobacteria,2YUKD@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the LOG family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4885353_5	1463825.JNXC01000002_gene4470	3.01e-17	90.0	2EBG5@1|root,335GQ@2|Bacteria,2GRUT@201174|Actinobacteria,4E78M@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4885353_6	1313172.YM304_32180	1.061e-05	54.0	COG0845@1|root,COG3409@1|root,COG0845@2|Bacteria,COG3409@2|Bacteria,2I9HW@201174|Actinobacteria	201174|Actinobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,PG_binding_1
CMS3_k127_491481_3	1294142.CINTURNW_0685	2.995e-14	76.0	COG1246@1|root,COG1246@2|Bacteria,1VUUV@1239|Firmicutes,25E0G@186801|Clostridia,36VY1@31979|Clostridiaceae	186801|Clostridia	E	Bacterial inner membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Imp-YgjV
CMS3_k127_491481_2	134676.ACPL_5090	5.031e-19	94.0	28VK2@1|root,2ZHNE@2|Bacteria,2IBCS@201174|Actinobacteria	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
CMS3_k127_491481_4	391625.PPSIR1_00967	1.654e-05	53.0	2DN1Z@1|root,32V20@2|Bacteria,1Q8W3@1224|Proteobacteria,43E1M@68525|delta/epsilon subdivisions,2WZFP@28221|Deltaproteobacteria,2Z21B@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_491481_1	1385521.N803_10210	3.371e-40	156.0	COG1309@1|root,COG1309@2|Bacteria,2GV75@201174|Actinobacteria,4FHF1@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
CMS3_k127_491481_0	196162.Noca_4966	1.745e-62	229.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria	201174|Actinobacteria	F	Drug exporters of the RND superfamily	-	-	-	ko:K06994,ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS3_k127_4944376_2	1128421.JAGA01000003_gene3009	1.353e-79	273.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,SGL,VCBS
CMS3_k127_4944376_0	35754.JNYJ01000044_gene4354	2.419e-122	414.0	COG1404@1|root,COG1404@2|Bacteria,2IAS7@201174|Actinobacteria,4DHP7@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
CMS3_k127_4944376_6	1229780.BN381_130349	8.513e-29	125.0	COG2755@1|root,COG2755@2|Bacteria,2HFQG@201174|Actinobacteria,3UXQ1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS3_k127_4944376_1	446470.Snas_2493	1.73e-114	378.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4EY8G@85014|Glycomycetales	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	moxR1	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_4944376_3	1380347.JNII01000005_gene3537	2.022e-77	268.0	COG1721@1|root,COG1721@2|Bacteria,2GKSJ@201174|Actinobacteria,4ES3V@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function DUF58	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_4944376_5	1385518.N798_04745	2.172e-65	235.0	COG2304@1|root,COG2304@2|Bacteria,2GNKP@201174|Actinobacteria,4FGG7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Von Willebrand factor A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
CMS3_k127_4944376_4	103733.JNYO01000009_gene4711	2.215e-67	251.0	COG1073@1|root,COG1073@2|Bacteria,2GMK3@201174|Actinobacteria,4E10C@85010|Pseudonocardiales	201174|Actinobacteria	S	Prolyl oligopeptidase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_4,Hydrolase_4,Peptidase_S9
CMS3_k127_4949787_4	1341181.FLJC2902T_25260	7.549e-05	48.0	COG0421@1|root,COG0421@2|Bacteria,4NTHI@976|Bacteroidetes,1IDKX@117743|Flavobacteriia,2NYQ7@237|Flavobacterium	976|Bacteroidetes	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4949787_3	1382306.JNIM01000001_gene3713	5.123e-16	80.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS3_k127_4949787_1	1123023.JIAI01000006_gene67	7.204e-21	100.0	COG0044@1|root,COG0044@2|Bacteria,2IARA@201174|Actinobacteria,4EENJ@85010|Pseudonocardiales	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
CMS3_k127_4949787_0	1123023.JIAI01000006_gene67	3.704e-126	413.0	COG0044@1|root,COG0044@2|Bacteria,2IARA@201174|Actinobacteria,4EENJ@85010|Pseudonocardiales	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
CMS3_k127_4949787_2	1380356.JNIK01000017_gene3066	5.592e-18	89.0	COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,LZ_Tnp_IS481,rve
CMS3_k127_4951309_4	397278.JOJN01000002_gene17	2.798e-19	96.0	COG2720@1|root,COG2720@2|Bacteria,2GISH@201174|Actinobacteria,4DN8K@85009|Propionibacteriales	201174|Actinobacteria	V	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
CMS3_k127_4951309_0	1449126.JQKL01000041_gene998	4.825e-111	375.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,267SX@186813|unclassified Clostridiales	186801|Clostridia	G	Pyruvate kinase, barrel domain	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
CMS3_k127_4951309_5	1088721.NSU_0477	4.379e-10	68.0	COG1920@1|root,COG1920@2|Bacteria,1RJPN@1224|Proteobacteria,2UAA7@28211|Alphaproteobacteria,2K6KN@204457|Sphingomonadales	204457|Sphingomonadales	S	Guanylyl transferase CofC like	-	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
CMS3_k127_4951309_1	1313172.YM304_14930	4.129e-62	224.0	COG2120@1|root,COG2120@2|Bacteria,2IR6Y@201174|Actinobacteria,4CN50@84992|Acidimicrobiia	84992|Acidimicrobiia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
CMS3_k127_4951309_2	278963.ATWD01000002_gene779	3.356e-39	155.0	COG4221@1|root,COG4221@2|Bacteria,3Y6ZB@57723|Acidobacteria,2JKUG@204432|Acidobacteriia	204432|Acidobacteriia	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_4951309_3	326424.FRAAL1760	7.606e-27	115.0	COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria,4ESUR@85013|Frankiales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
CMS3_k127_4968324_1	196162.Noca_4966	2.76e-98	332.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria	201174|Actinobacteria	F	Drug exporters of the RND superfamily	-	-	-	ko:K06994,ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS3_k127_4968324_4	1123023.JIAI01000003_gene3072	9.171e-38	145.0	COG0346@1|root,COG0346@2|Bacteria,2IQE0@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_4968324_3	1229780.BN381_70127	1.171e-52	195.0	294HY@1|root,2ZRXK@2|Bacteria	2|Bacteria	S	YwiC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YwiC
CMS3_k127_4968324_2	446466.Cfla_3072	5.772e-58	214.0	COG0520@1|root,COG0520@2|Bacteria,2GJA4@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase class v	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_4968324_0	1122138.AQUZ01000044_gene4502	1.192e-103	353.0	COG0701@1|root,COG0701@2|Bacteria,2HZBT@201174|Actinobacteria	201174|Actinobacteria	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
CMS3_k127_4968324_5	1894.JOER01000051_gene5467	1.879e-30	123.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
CMS3_k127_4968324_6	1229780.BN381_310004	1.275e-25	113.0	COG2050@1|root,COG2050@2|Bacteria,2HP0Q@201174|Actinobacteria,3UXPT@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS3_k127_4968634_0	929712.KI912613_gene3662	1.261e-66	237.0	COG1305@1|root,COG1305@2|Bacteria,2GMGI@201174|Actinobacteria	201174|Actinobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
CMS3_k127_4968634_1	861299.J421_1282	2.559e-22	101.0	COG2911@1|root,COG3209@1|root,COG4625@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria,COG4625@2|Bacteria	2|Bacteria	T	pathogenesis	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_5,CHU_C,Calx-beta,DUF4347,HemolysinCabind,PATR
CMS3_k127_4968634_4	1380390.JIAT01000010_gene4927	8.904e-13	72.0	COG1595@1|root,COG1595@2|Bacteria,2IRNG@201174|Actinobacteria,4CTBE@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_4968634_3	477641.MODMU_4215	1.879e-13	81.0	COG2374@1|root,COG2931@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,2I2E0@201174|Actinobacteria,4ESXB@85013|Frankiales	201174|Actinobacteria	Q	Endonuclease/Exonuclease/phosphatase family	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Exo_endo_phos,LTD
CMS3_k127_4968634_5	1449355.JQNR01000003_gene72	1.179e-11	71.0	COG1595@1|root,COG1595@2|Bacteria,2GM6A@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_4968634_2	882083.SacmaDRAFT_1428	7.179e-20	91.0	2ESE5@1|root,33JYU@2|Bacteria,2IS59@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4968634_6	101510.RHA1_ro11304	1.551e-09	61.0	2A15N@1|root,30PBK@2|Bacteria,2HMDE@201174|Actinobacteria,4G58F@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5036252_0	298653.Franean1_6600	5.59e-105	375.0	COG2319@1|root,COG3629@1|root,COG2319@2|Bacteria,COG3629@2|Bacteria,2GJN3@201174|Actinobacteria,4ES8H@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,PD40,Trans_reg_C,WD40
CMS3_k127_5036252_1	756272.Plabr_1631	1.06e-27	117.0	COG0569@1|root,COG0569@2|Bacteria	2|Bacteria	P	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TrkA_C
CMS3_k127_5043825_0	1380394.JADL01000004_gene6111	9.122e-181	576.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,2JREU@204441|Rhodospirillales	204441|Rhodospirillales	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
CMS3_k127_5052746_0	1128421.JAGA01000002_gene864	1.483e-133	437.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_5052746_4	529818.AMSG_09806T0	7.982e-40	163.0	COG0153@1|root,KOG0631@2759|Eukaryota	2759|Eukaryota	G	galactokinase activity	-	GO:0003674,GO:0003824,GO:0004335,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006012,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0019320,GO:0019388,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.157	ko:K18674	-	-	-	-	ko00000,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
CMS3_k127_5052746_5	497964.CfE428DRAFT_2729	5.463e-34	141.0	COG1209@1|root,COG1209@2|Bacteria,46T9Q@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Nucleotidyl transferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CMS3_k127_5052746_3	35754.JNYJ01000050_gene7957	2.194e-105	353.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria,4DAEY@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
CMS3_k127_5052746_7	471856.Jden_2019	5.796e-18	86.0	COG1749@1|root,COG1749@2|Bacteria,2I62V@201174|Actinobacteria	201174|Actinobacteria	N	Flagellar basal body rod protein	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
CMS3_k127_5052746_8	1231241.Mc24_08119	3.836e-12	68.0	COG1582@1|root,COG1582@2|Bacteria,2GDIZ@200918|Thermotogae	200918|Thermotogae	N	flagellar	-	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
CMS3_k127_5052746_6	1283299.AUKG01000006_gene858	6.486e-23	107.0	2E2N6@1|root,32XRB@2|Bacteria,2IH9D@201174|Actinobacteria,4CTPC@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5052746_2	476272.RUMHYD_02346	1.628e-105	357.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,3XZ92@572511|Blautia	186801|Clostridia	H	Psort location Cytoplasmic, score 8.87	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_5052746_1	1123320.KB889675_gene4065	1.18e-107	356.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
CMS3_k127_5059821_3	465541.ATCJ01000005_gene5839	4.945e-28	124.0	COG1524@1|root,COG1524@2|Bacteria,2GISU@201174|Actinobacteria	201174|Actinobacteria	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
CMS3_k127_5059821_2	1179778.PMM47T1_16273	1.646e-38	153.0	COG3531@1|root,COG3531@2|Bacteria,1RIN9@1224|Proteobacteria,1S4YF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Protein-disulfide isomerase	-	-	-	ko:K07396	-	-	-	-	ko00000	-	-	-	DSBA
CMS3_k127_5059821_4	1120936.KB907226_gene2805	2.194e-27	121.0	COG3675@1|root,COG3675@2|Bacteria,2HBD6@201174|Actinobacteria	201174|Actinobacteria	I	Lipase (class 3)	-	-	3.1.1.3	ko:K01046	ko00561,ko01100,map00561,map01100	M00098	R02250,R02687	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko00002,ko01000	-	-	-	Lipase_3
CMS3_k127_5059821_0	247639.MGP2080_02126	5.946e-121	400.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1S0H1@1236|Gammaproteobacteria,1JBTT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Zn-dependent alcohol dehydrogenases	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_5059821_1	1123504.JQKD01000002_gene3996	7.604e-89	304.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2VM19@28216|Betaproteobacteria,4ABT0@80864|Comamonadaceae	28216|Betaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
CMS3_k127_5064794_2	448385.sce0574	3.086e-64	235.0	COG2114@1|root,COG3322@1|root,COG2114@2|Bacteria,COG3322@2|Bacteria,1QWNC@1224|Proteobacteria,42ZRB@68525|delta/epsilon subdivisions,2WV1J@28221|Deltaproteobacteria,2YV0C@29|Myxococcales	28221|Deltaproteobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE4,Guanylate_cyc
CMS3_k127_5064794_3	1380347.JNII01000007_gene307	9.53e-60	221.0	2E9HK@1|root,333QQ@2|Bacteria,2I89Z@201174|Actinobacteria,4ETI2@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5064794_1	1313172.YM304_00870	4.741e-112	371.0	COG0388@1|root,COG0388@2|Bacteria,2H03Y@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.5.1	ko:K01501	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
CMS3_k127_5064794_0	479434.Sthe_2363	0.0	1516.0	COG0209@1|root,COG0209@2|Bacteria,2G8RN@200795|Chloroflexi,27Y2V@189775|Thermomicrobia	189775|Thermomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
CMS3_k127_5087604_5	1120705.FG95_02214	7.151e-09	67.0	COG0657@1|root,COG0657@2|Bacteria,1N2XW@1224|Proteobacteria,2U3QT@28211|Alphaproteobacteria,2K2SB@204457|Sphingomonadales	204457|Sphingomonadales	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,COesterase
CMS3_k127_5087604_1	66373.JOFQ01000020_gene6870	1.615e-59	216.0	COG0491@1|root,COG0491@2|Bacteria,2H8JM@201174|Actinobacteria	201174|Actinobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_5087604_2	1429046.RR21198_1573	7.949e-52	193.0	COG2021@1|root,COG2021@2|Bacteria,2IMKC@201174|Actinobacteria,4G03M@85025|Nocardiaceae	201174|Actinobacteria	E	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4
CMS3_k127_5087604_0	1121272.KB903289_gene4363	5.58e-63	234.0	COG1403@1|root,COG1403@2|Bacteria,2INVR@201174|Actinobacteria	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
CMS3_k127_5087604_4	1120941.AUBL01000009_gene832	6.552e-17	92.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,4D4DN@85005|Actinomycetales	201174|Actinobacteria	NU	Type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
CMS3_k127_5087604_3	222534.KB893683_gene1113	1.86e-35	145.0	COG4965@1|root,COG4965@2|Bacteria,2I3KW@201174|Actinobacteria,4EXBE@85013|Frankiales	201174|Actinobacteria	U	Type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
CMS3_k127_5093215_1	47763.JNZA01000001_gene4238	3.709e-33	143.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_5093215_0	1085623.GNIT_3021	1.598e-139	457.0	COG1073@1|root,COG1073@2|Bacteria,1QY08@1224|Proteobacteria,1SJFT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5093257_0	504728.K649_07895	8.093e-71	252.0	COG1171@1|root,COG1171@2|Bacteria,1WJZG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_5093257_1	751945.Theos_0153	5.811e-44	164.0	COG0663@1|root,COG0663@2|Bacteria,1WIVI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Carbonic anhydrase acetyltransferase isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
CMS3_k127_5097617_10	35754.JNYJ01000001_gene7247	0.0002251	51.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS3_k127_5097617_6	1206726.BAFV01000015_gene832	1.087e-54	207.0	COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria,4FVMK@85025|Nocardiaceae	201174|Actinobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
CMS3_k127_5097617_1	926569.ANT_01210	5.252e-185	588.0	COG0402@1|root,COG0402@2|Bacteria,2G5X1@200795|Chloroflexi	200795|Chloroflexi	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_5097617_5	313589.JNB_08044	3.46e-60	211.0	COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4FGEI@85021|Intrasporangiaceae	201174|Actinobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
CMS3_k127_5097617_8	1294265.JCM21738_3752	7.221e-38	155.0	COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,4HH3B@91061|Bacilli,1ZG6R@1386|Bacillus	91061|Bacilli	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
CMS3_k127_5097617_2	110319.CF8_0740	5.788e-115	385.0	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4DNFP@85009|Propionibacteriales	201174|Actinobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0008150,GO:0040007	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS3_k127_5097617_0	697284.ERIC2_c37770	6.95e-209	667.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,4H9R4@91061|Bacilli,26QAT@186822|Paenibacillaceae	91061|Bacilli	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
CMS3_k127_5097617_9	234267.Acid_6712	5.006e-24	105.0	COG0736@1|root,COG0736@2|Bacteria,3Y590@57723|Acidobacteria	57723|Acidobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
CMS3_k127_5097617_4	429009.Adeg_1759	2.102e-62	233.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,42EWB@68295|Thermoanaerobacterales	186801|Clostridia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	ACPS,Carb_kinase,YjeF_N
CMS3_k127_5097617_3	1313172.YM304_08920	2.087e-94	322.0	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4CN11@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
CMS3_k127_5097617_7	1192124.LIG30_3193	4.222e-51	190.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2VPZQ@28216|Betaproteobacteria,1K1QM@119060|Burkholderiaceae	28216|Betaproteobacteria	L	TIGRFAM phage SPO1 DNA polymerase-related protein	dpo	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS3_k127_5109756_11	1123368.AUIS01000009_gene2452	3.326e-24	114.0	COG0739@1|root,COG0739@2|Bacteria,1RK0U@1224|Proteobacteria,1S6P9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Peptidase family M23	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
CMS3_k127_5109756_6	644282.Deba_3053	7.645e-63	239.0	COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BT2@68525|delta/epsilon subdivisions,2WM4H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
CMS3_k127_5109756_8	644966.Tmar_1372	4.315e-39	156.0	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,25B1X@186801|Clostridia,3WDTH@538999|Clostridiales incertae sedis	186801|Clostridia	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K11618	ko02020,map02020	M00481,M00754	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
CMS3_k127_5109756_0	744979.R2A130_1503	5.943e-134	443.0	COG0604@1|root,COG0604@2|Bacteria,1MW2V@1224|Proteobacteria,2U07M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_5109756_2	1121272.KB903290_gene4678	5.734e-103	346.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria,4DHRJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5109756_3	268407.PWYN_26870	4.66e-91	310.0	COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,4H9WF@91061|Bacilli,26SJF@186822|Paenibacillaceae	91061|Bacilli	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
CMS3_k127_5109756_7	525246.HMPREF0058_0256	1.002e-62	230.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4D440@85005|Actinomycetales	201174|Actinobacteria	P	CBS domain protein	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
CMS3_k127_5109756_10	1384484.AEQU_1076	2.577e-24	109.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4CVZI@84998|Coriobacteriia	84998|Coriobacteriia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
CMS3_k127_5109756_4	1121468.AUBR01000018_gene2706	2.347e-73	276.0	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,249W0@186801|Clostridia,42EY4@68295|Thermoanaerobacterales	186801|Clostridia	S	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
CMS3_k127_5109756_1	1121272.KB903258_gene5365	6.988e-113	372.0	COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,4DC9N@85008|Micromonosporales	201174|Actinobacteria	T	PhoH-like protein	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
CMS3_k127_5109756_9	1229780.BN381_80274	9.318e-37	145.0	COG1396@1|root,COG1396@2|Bacteria,2I569@201174|Actinobacteria	201174|Actinobacteria	K	PFAM helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
CMS3_k127_5109756_5	1298863.AUEP01000005_gene2556	1.123e-69	245.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,4DPD2@85009|Propionibacteriales	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
CMS3_k127_5111855_6	290397.Adeh_3081	4.244e-39	149.0	COG2303@1|root,COG2303@2|Bacteria,1NV3A@1224|Proteobacteria,42NVR@68525|delta/epsilon subdivisions,2WM9A@28221|Deltaproteobacteria,2YU0T@29|Myxococcales	28221|Deltaproteobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
CMS3_k127_5111855_5	593117.TGAM_1016	5.379e-53	200.0	COG1840@1|root,arCOG00227@2157|Archaea,2Y6PD@28890|Euryarchaeota,24507@183968|Thermococci	183968|Thermococci	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
CMS3_k127_5111855_4	177437.HRM2_47620	8.475e-76	265.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42MHF@68525|delta/epsilon subdivisions,2WJ1R@28221|Deltaproteobacteria,2MJ2Y@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Dehydrogenase E1 component	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
CMS3_k127_5111855_3	1449126.JQKL01000003_gene1819	4.321e-90	306.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,26AI0@186813|unclassified Clostridiales	186801|Clostridia	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS3_k127_5111855_7	319003.Bra1253DRAFT_01647	2.054e-17	85.0	COG3360@1|root,COG3360@2|Bacteria,1PE74@1224|Proteobacteria,2UCH8@28211|Alphaproteobacteria,3K04J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
CMS3_k127_5111855_8	91464.S7335_2703	2.66e-15	79.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
CMS3_k127_5111855_0	1121861.KB899953_gene2383	1.945e-196	641.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,2TVN2@28211|Alphaproteobacteria,2JVBX@204441|Rhodospirillales	204441|Rhodospirillales	HP	MoeA C-terminal region (domain IV)	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
CMS3_k127_5111855_2	1254432.SCE1572_52485	2.773e-115	389.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42M5U@68525|delta/epsilon subdivisions,2WJ06@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
CMS3_k127_5111855_1	592015.HMPREF1705_01067	8.969e-183	592.0	COG2414@1|root,COG2414@2|Bacteria	2|Bacteria	C	aldehyde ferredoxin oxidoreductase activity	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS3_k127_5171588_4	1214101.BN159_0381	1.288e-10	66.0	2CD54@1|root,332HS@2|Bacteria,2I8A2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5171588_5	1246995.AFR_13425	5.248e-09	63.0	2CD54@1|root,332HS@2|Bacteria,2I8A2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5171588_2	1227360.C176_20619	9.831e-54	194.0	COG0105@1|root,COG0105@2|Bacteria,1V44G@1239|Firmicutes,4HH8C@91061|Bacilli,26EXX@186818|Planococcaceae	91061|Bacilli	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
CMS3_k127_5171588_1	356851.JOAN01000031_gene5220	6.861e-84	294.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4D95V@85008|Micromonosporales	201174|Actinobacteria	H	Belongs to the folylpolyglutamate synthase family	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2447c	Mur_ligase_C,Mur_ligase_M
CMS3_k127_5171588_0	485915.Dret_0251	4.992e-96	328.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2M99R@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
CMS3_k127_5200853_0	1386089.N865_02050	3.878e-33	131.0	COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria,4FI6F@85021|Intrasporangiaceae	201174|Actinobacteria	L	transposase	-	-	-	-	-	-	-	-	-	-	-	-	LZ_Tnp_IS481,rve,rve_3
CMS3_k127_5200853_2	1349820.M707_23260	1.683e-09	65.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,1W7QH@1268|Micrococcaceae	201174|Actinobacteria	L	PFAM Transposase, Mutator family	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
CMS3_k127_5200853_1	653045.Strvi_4707	1.9e-19	93.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	tnp3508a	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
CMS3_k127_5200853_3	670487.Ocepr_0101	3.016e-09	70.0	COG2010@1|root,COG2010@2|Bacteria,1WIF2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
CMS3_k127_5200853_5	1485545.JQLW01000007_gene653	0.0005988	53.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	FixQ
CMS3_k127_5200853_4	1385512.N784_12705	3.097e-06	60.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,1TRS8@1239|Firmicutes,4H9XH@91061|Bacilli,2Y9QT@289201|Pontibacillus	91061|Bacilli	C	Cytochrome Cbb3	qcrC	-	-	ko:K03888	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_C,Cytochrome_CBB3
CMS3_k127_52097_4	1136417.AZWE01000066_gene1147	5.094e-28	115.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4D9V4@85008|Micromonosporales	201174|Actinobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS3_k127_52097_0	404589.Anae109_2804	3.957e-91	315.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,42SJR@68525|delta/epsilon subdivisions,2WRRB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
CMS3_k127_52097_2	713587.THITH_07545	1.251e-45	169.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,1S6HB@1236|Gammaproteobacteria,1X24R@135613|Chromatiales	135613|Chromatiales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS3_k127_52097_3	43354.JOIJ01000001_gene396	9.838e-44	179.0	COG3147@1|root,COG3147@2|Bacteria,2GYC2@201174|Actinobacteria,4ECZ4@85010|Pseudonocardiales	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_52097_1	1169152.AXVD01000023_gene3256	3.979e-90	306.0	COG2021@1|root,COG2021@2|Bacteria,2HIEG@201174|Actinobacteria,4G3VG@85025|Nocardiaceae	201174|Actinobacteria	E	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_5235083_2	1121033.AUCF01000014_gene1318	3.143e-30	124.0	COG1545@1|root,COG1545@2|Bacteria,1RB09@1224|Proteobacteria,2U5BV@28211|Alphaproteobacteria,2JU23@204441|Rhodospirillales	204441|Rhodospirillales	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N,OB_aCoA_assoc
CMS3_k127_5235083_1	323097.Nham_3239	8.536e-72	249.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2U9HZ@28211|Alphaproteobacteria,3K0YK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044424,GO:0044464	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
CMS3_k127_5235083_0	675635.Psed_6203	6.899e-125	409.0	COG2141@1|root,COG2141@2|Bacteria,2GMUP@201174|Actinobacteria,4EBZH@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_5235083_3	1382306.JNIM01000001_gene536	1.013e-28	121.0	COG2079@1|root,COG2079@2|Bacteria	2|Bacteria	S	2-methylcitrate dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
CMS3_k127_5266005_20	710696.Intca_0171	2.119e-18	91.0	COG1196@1|root,COG1196@2|Bacteria,2IMXX@201174|Actinobacteria,4FHC2@85021|Intrasporangiaceae	201174|Actinobacteria	D	Protein of unknown function (DUF4446)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4446
CMS3_k127_5266005_1	28444.JODQ01000009_gene3755	3.797e-129	424.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4EH2Z@85012|Streptosporangiales	201174|Actinobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
CMS3_k127_5266005_17	1254432.SCE1572_18290	7.759e-25	114.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,42P2Z@68525|delta/epsilon subdivisions,2WNJ6@28221|Deltaproteobacteria,2YU8C@29|Myxococcales	28221|Deltaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
CMS3_k127_5266005_7	1116375.VEJY3_20426	1.839e-68	261.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1XTQN@135623|Vibrionales	135623|Vibrionales	M	Belongs to the peptidase S8 family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I9,PKD,PPC,Peptidase_S8
CMS3_k127_5266005_21	180281.CPCC7001_1703	2.244e-13	76.0	COG0589@1|root,COG0589@2|Bacteria,1GHFZ@1117|Cyanobacteria,22STZ@167375|Cyanobium	1117|Cyanobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_5266005_26	1194972.MVAC_10302	0.000164	49.0	COG3467@1|root,COG3467@2|Bacteria,2IKUR@201174|Actinobacteria,23AWY@1762|Mycobacteriaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
CMS3_k127_5266005_19	436114.SYO3AOP1_0081	1.072e-22	102.0	COG0589@1|root,COG0589@2|Bacteria,2G4D6@200783|Aquificae	200783|Aquificae	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_5266005_13	1313172.YM304_28460	2.139e-55	207.0	COG4585@1|root,COG4585@2|Bacteria,2I312@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HATPase_c_2,HisKA_3
CMS3_k127_5266005_9	1449353.JQMQ01000005_gene2960	7.06e-64	227.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,2NF0X@228398|Streptacidiphilus	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_5266005_6	309803.CTN_0476	1.778e-68	248.0	COG0205@1|root,COG0205@2|Bacteria,2GBZ8@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
CMS3_k127_5266005_15	469371.Tbis_3536	1.264e-45	169.0	COG0590@1|root,COG0590@2|Bacteria,2IM3Z@201174|Actinobacteria,4E3MF@85010|Pseudonocardiales	201174|Actinobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.1,3.5.4.33	ko:K01485,ko:K11991	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922,R10223	RC00074,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
CMS3_k127_5266005_22	1157640.AQWO01000010_gene2863	4.79e-08	60.0	2BH8E@1|root,32B9R@2|Bacteria,2IJMM@201174|Actinobacteria	201174|Actinobacteria	S	Chagasin family peptidase inhibitor I42	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	Inhibitor_I42
CMS3_k127_5266005_8	1146883.BLASA_4688	3.982e-67	259.0	COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,TIG
CMS3_k127_5266005_16	749927.AMED_2106	1.699e-35	154.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria,4DYBQ@85010|Pseudonocardiales	201174|Actinobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
CMS3_k127_5266005_5	103733.JNYO01000031_gene1574	1.414e-84	291.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria,4DX3X@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS3_k127_5266005_10	1121381.JNIV01000001_gene2856	1.026e-62	226.0	COG1834@1|root,COG1834@2|Bacteria	2|Bacteria	E	dimethylargininase activity	-	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
CMS3_k127_5266005_4	35754.JNYJ01000021_gene430	9.103e-85	296.0	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria,4DHJ8@85008|Micromonosporales	201174|Actinobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS3_k127_5266005_3	1166018.FAES_3034	3.006e-96	323.0	COG0006@1|root,COG0006@2|Bacteria,4NF0F@976|Bacteroidetes,47JWC@768503|Cytophagia	976|Bacteroidetes	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
CMS3_k127_5266005_18	1247963.JPHU01000020_gene2982	9.078e-25	107.0	COG0006@1|root,COG0006@2|Bacteria,1MVHD@1224|Proteobacteria,2UCJB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
CMS3_k127_5266005_11	316274.Haur_1012	8.499e-60	219.0	COG0454@1|root,COG1246@1|root,COG0456@2|Bacteria,COG1246@2|Bacteria,2G8UQ@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_5266005_0	1123023.JIAI01000010_gene8509	2.479e-225	710.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DXDJ@85010|Pseudonocardiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_5266005_25	187272.Mlg_0315	1.881e-05	53.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_5266005_23	28229.ND2E_3464	2.77e-07	63.0	COG2223@1|root,COG2223@2|Bacteria,1QUWD@1224|Proteobacteria,1T23J@1236|Gammaproteobacteria,2Q7YC@267889|Colwelliaceae	1236|Gammaproteobacteria	P	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_5266005_24	1133850.SHJG_7316	4.297e-06	57.0	COG0477@1|root,COG2814@2|Bacteria,2GMWE@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_5266005_2	373903.Hore_21510	1.557e-110	372.0	COG0517@1|root,COG4175@1|root,COG0517@2|Bacteria,COG4175@2|Bacteria,1UHNE@1239|Firmicutes,25EJ1@186801|Clostridia,3WAF7@53433|Halanaerobiales	186801|Clostridia	E	TIGRFAM glycine betaine L-proline transport ATP binding subunit	opuAA	-	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran,CBS
CMS3_k127_5266005_12	1122211.JMLW01000017_gene1618	1.375e-57	225.0	COG4176@1|root,COG4176@2|Bacteria,1MUM4@1224|Proteobacteria,1RPQS@1236|Gammaproteobacteria,1XI8C@135619|Oceanospirillales	135619|Oceanospirillales	E	ABC transporter permease	-	-	-	ko:K02001	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
CMS3_k127_5266005_14	570967.JMLV01000008_gene1338	5.525e-53	203.0	COG2113@1|root,COG2113@2|Bacteria,1MWZU@1224|Proteobacteria,2TSYB@28211|Alphaproteobacteria,2JQ0I@204441|Rhodospirillales	204441|Rhodospirillales	E	Substrate binding domain of ABC-type glycine betaine transport system	proX	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
CMS3_k127_5272722_10	1869.MB27_02745	2.719e-22	108.0	COG1277@1|root,COG1277@2|Bacteria,2GKKP@201174|Actinobacteria,4D8U0@85008|Micromonosporales	201174|Actinobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
CMS3_k127_5272722_3	479434.Sthe_1081	1.59e-85	300.0	COG1131@1|root,COG1131@2|Bacteria,2G6B8@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_5272722_11	1246995.AFR_05235	1.909e-11	74.0	COG1277@1|root,COG1277@2|Bacteria,2GK3E@201174|Actinobacteria,4D9FS@85008|Micromonosporales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
CMS3_k127_5272722_2	1121434.AULY01000006_gene901	6.196e-95	331.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2MA1S@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
CMS3_k127_5272722_6	1313172.YM304_26230	2.48e-56	201.0	293MU@1|root,2ZR3M@2|Bacteria,2IFCB@201174|Actinobacteria,4CN73@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Nickel-containing superoxide dismutase	sodN	-	1.15.1.1	ko:K00518	-	-	-	-	ko00000,ko01000	-	-	-	Sod_Ni
CMS3_k127_5272722_9	1229780.BN381_90102	2.957e-23	106.0	COG0681@1|root,COG0681@2|Bacteria	2|Bacteria	U	signal peptide processing	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
CMS3_k127_5272722_5	1313172.YM304_41130	2.907e-63	228.0	COG1112@1|root,COG1198@1|root,COG1112@2|Bacteria,COG1198@2|Bacteria	2|Bacteria	L	DNA replication, synthesis of RNA primer	ydjG	-	3.6.4.12	ko:K04066,ko:K10742	ko03030,ko03440,map03030,map03440	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	AAA_11,AAA_12,Band_7_1,DUF4011,DZR,TF_Zn_Ribbon
CMS3_k127_5272722_7	164757.Mjls_5709	1.601e-50	187.0	COG4912@1|root,COG4912@2|Bacteria,2GNQD@201174|Actinobacteria,23D40@1762|Mycobacteriaceae	201174|Actinobacteria	L	DNA alkylation repair enzyme	alkD	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
CMS3_k127_5272722_8	446469.Sked_07280	2.501e-43	172.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
CMS3_k127_5272722_4	1382304.JNIL01000001_gene660	8.039e-75	269.0	COG0154@1|root,COG0154@2|Bacteria,1TR9X@1239|Firmicutes,4HAYP@91061|Bacilli,27AQ0@186823|Alicyclobacillaceae	91061|Bacilli	J	Amidase	gatA3	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS3_k127_5272722_0	58123.JOFJ01000002_gene2665	1.734e-243	766.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4EFQQ@85012|Streptosporangiales	201174|Actinobacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
CMS3_k127_5272722_1	1120936.KB907214_gene4557	3.803e-142	458.0	COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria,4EH97@85012|Streptosporangiales	201174|Actinobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
CMS3_k127_5272722_12	1121272.KB903249_gene1465	2.817e-11	70.0	COG3557@1|root,COG3557@2|Bacteria,2IQ8M@201174|Actinobacteria,4DCQR@85008|Micromonosporales	201174|Actinobacteria	J	domain protein associated with RNAses G and E	-	-	-	ko:K07586	-	-	-	-	ko00000	-	-	-	DUF402
CMS3_k127_5295111_0	471857.Svir_13420	0.0	1305.0	COG1643@1|root,COG1643@2|Bacteria,2GIWX@201174|Actinobacteria,4E02F@85010|Pseudonocardiales	201174|Actinobacteria	L	TIGRFAM ATP-dependent helicase HrpA	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
CMS3_k127_5295111_3	1313172.YM304_07120	1.232e-68	241.0	COG3836@1|root,COG3836@2|Bacteria,2HGEA@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
CMS3_k127_5295111_2	1313172.YM304_07180	5.642e-85	290.0	COG2141@1|root,COG2141@2|Bacteria,2GMMJ@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	rutA_3	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_5295111_1	1380347.JNII01000007_gene334	9.667e-155	507.0	COG0671@1|root,COG1718@1|root,COG0671@2|Bacteria,COG1718@2|Bacteria	2|Bacteria	DT	cellular response to dsDNA	kdkA	-	2.7.1.166,3.6.1.27	ko:K11211,ko:K19302	ko00540,ko00550,map00540,map00550	-	R05627,R09767	RC00002,RC00078	ko00000,ko00001,ko01000,ko01011	-	-	-	Kdo,PAP2
CMS3_k127_5305588_1	1242864.D187_005729	5.859e-65	232.0	COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria,43C66@68525|delta/epsilon subdivisions,2X7GD@28221|Deltaproteobacteria,2Z3G5@29|Myxococcales	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_5305588_0	106370.Francci3_2796	2.729e-170	555.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4ERWA@85013|Frankiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpE	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
CMS3_k127_5364219_1	266117.Rxyl_0238	1.836e-143	464.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4CPJR@84995|Rubrobacteria	84995|Rubrobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
CMS3_k127_5364219_4	1313172.YM304_05060	5.864e-18	91.0	COG1413@1|root,COG1413@2|Bacteria,2HA0J@201174|Actinobacteria,4CNCY@84992|Acidimicrobiia	84992|Acidimicrobiia	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
CMS3_k127_5364219_3	526227.Mesil_2065	2.055e-42	163.0	COG1309@1|root,COG1309@2|Bacteria,1WI7P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_C_5,TetR_N
CMS3_k127_5364219_2	1121033.AUCF01000014_gene1279	5.348e-126	422.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TSGF@28211|Alphaproteobacteria,2JPV5@204441|Rhodospirillales	204441|Rhodospirillales	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	paaH	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
CMS3_k127_5364219_0	1238182.C882_1306	1.126e-157	506.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2JQ5R@204441|Rhodospirillales	204441|Rhodospirillales	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_5384662_11	68194.JNXR01000016_gene7403	4.431e-12	78.0	COG5485@1|root,COG5485@2|Bacteria,2GJYB@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL
CMS3_k127_5384662_12	251221.35214038	2.477e-11	75.0	COG5485@1|root,COG5485@2|Bacteria,1GEUM@1117|Cyanobacteria	1117|Cyanobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
CMS3_k127_5384662_5	1128912.GMES_2241	3.876e-45	171.0	COG1028@1|root,COG1028@2|Bacteria,1MW46@1224|Proteobacteria,1S08S@1236|Gammaproteobacteria,46B8W@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
CMS3_k127_5384662_6	1123023.JIAI01000002_gene5798	3.689e-43	171.0	COG1522@1|root,COG1522@2|Bacteria,2GP1P@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
CMS3_k127_5384662_1	479431.Namu_4720	1.223e-178	576.0	COG3243@1|root,COG3243@2|Bacteria,2GNYP@201174|Actinobacteria,4ETZS@85013|Frankiales	201174|Actinobacteria	I	PFAM Poly-beta-hydroxybutyrate polymerase domain protein	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
CMS3_k127_5384662_10	1121440.AUMA01000010_gene356	2.662e-16	86.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2MESR@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CMS3_k127_5384662_8	1121440.AUMA01000010_gene356	1.08e-19	91.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2MESR@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CMS3_k127_5384662_9	391625.PPSIR1_24954	8.83e-17	85.0	COG1225@1|root,COG1225@2|Bacteria,1NN23@1224|Proteobacteria,42XJF@68525|delta/epsilon subdivisions,2WTAE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	AhpC/TSA antioxidant enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA_2
CMS3_k127_5384662_13	391625.PPSIR1_24954	1.994e-07	54.0	COG1225@1|root,COG1225@2|Bacteria,1NN23@1224|Proteobacteria,42XJF@68525|delta/epsilon subdivisions,2WTAE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	AhpC/TSA antioxidant enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA_2
CMS3_k127_5384662_2	1463934.JOCF01000086_gene375	6.49e-153	492.0	COG1834@1|root,COG1834@2|Bacteria,2I99J@201174|Actinobacteria	201174|Actinobacteria	E	amidinotransferase	gatM	-	2.1.4.1	ko:K00613	ko00260,ko00330,ko01100,map00260,map00330,map01100	M00047	R00565,R01989	RC00024,RC02749	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidinotransf
CMS3_k127_5384662_0	927658.AJUM01000037_gene2274	5.319e-208	662.0	COG2403@1|root,COG2403@2|Bacteria,4NHIW@976|Bacteroidetes,2FNNX@200643|Bacteroidia	976|Bacteroidetes	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5384662_7	448385.sce1138	8.309e-43	162.0	COG1670@1|root,COG1670@2|Bacteria,1N4JG@1224|Proteobacteria,43DM6@68525|delta/epsilon subdivisions,2X65M@28221|Deltaproteobacteria,2Z393@29|Myxococcales	28221|Deltaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
CMS3_k127_5384662_4	33898.JRHJ01000069_gene7054	1.21e-69	248.0	COG1028@1|root,COG1028@2|Bacteria,2I41V@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_5384662_3	469383.Cwoe_2179	1.956e-107	366.0	COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria,4CQ2U@84995|Rubrobacteria	201174|Actinobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
CMS3_k127_540863_11	590998.Celf_1386	2.78e-24	108.0	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria,4F0FD@85016|Cellulomonadaceae	201174|Actinobacteria	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N,MMR_HSR1
CMS3_k127_540863_15	1122611.KB903960_gene4337	1.995e-18	94.0	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria,4EHPC@85012|Streptosporangiales	201174|Actinobacteria	S	50S ribosome-binding GTPase	PPA1638	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
CMS3_k127_540863_18	571166.KI421509_gene1872	4.126e-10	68.0	COG2847@1|root,COG2847@2|Bacteria,1N6G9@1224|Proteobacteria,2UERI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Copper chaperone PCu(A)C	-	-	-	-	-	-	-	-	-	-	-	-	PCuAC
CMS3_k127_540863_4	1156919.QWC_24387	5.336e-110	377.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,2VJZV@28216|Betaproteobacteria,3T4JU@506|Alcaligenaceae	28216|Betaproteobacteria	F	COG0044 Dihydroorotase and related cyclic amidohydrolases	-	-	3.5.2.2,3.5.2.5	ko:K01464,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00546	R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
CMS3_k127_540863_5	257310.BB4720	1.508e-81	282.0	COG0329@1|root,COG0329@2|Bacteria,1MWV5@1224|Proteobacteria,2VMFS@28216|Betaproteobacteria,3T49Q@506|Alcaligenaceae	28216|Betaproteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CMS3_k127_540863_8	391624.OIHEL45_03450	3.4e-40	159.0	COG4126@1|root,COG4126@2|Bacteria,1Q1CD@1224|Proteobacteria,2TXDM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Hydantoin racemase	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Glu_race
CMS3_k127_540863_14	1116369.KB890024_gene2922	4.16e-20	97.0	COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,2VGT2@28211|Alphaproteobacteria,43RQ6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
CMS3_k127_540863_12	644282.Deba_1257	5.019e-23	104.0	COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,42RKE@68525|delta/epsilon subdivisions,2WS0D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
CMS3_k127_540863_17	1048339.KB913029_gene3242	1.248e-10	69.0	COG1309@1|root,COG1309@2|Bacteria,2HE48@201174|Actinobacteria,4ET8R@85013|Frankiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_540863_0	269800.Tfu_0210	7.389e-198	633.0	COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria,4EFZX@85012|Streptosporangiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase N terminal	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
CMS3_k127_540863_7	1128421.JAGA01000003_gene3009	3.608e-48	186.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,SGL,VCBS
CMS3_k127_540863_2	443143.GM18_0358	2.184e-142	473.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS3_k127_540863_3	1961.JOAK01000023_gene3767	1.608e-129	426.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria	201174|Actinobacteria	M	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_540863_1	443143.GM18_0358	4.615e-148	490.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS3_k127_540863_19	1127134.NOCYR_3065	3.93e-08	58.0	COG1977@1|root,COG1977@2|Bacteria,2GQM9@201174|Actinobacteria,4G3HC@85025|Nocardiaceae	201174|Actinobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
CMS3_k127_540863_9	875328.JDM601_0284	5.564e-30	128.0	COG1571@1|root,COG1571@2|Bacteria,2IHSS@201174|Actinobacteria,23DEG@1762|Mycobacteriaceae	201174|Actinobacteria	S	tRNA wobble cytosine modification	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_540863_20	262316.MAP_0120c	8.922e-06	53.0	291VV@1|root,2ZPFK@2|Bacteria,2GYIS@201174|Actinobacteria,23DVY@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_540863_13	118163.Ple7327_3596	5.506e-22	113.0	COG1028@1|root,COG3291@1|root,COG1028@2|Bacteria,COG3291@2|Bacteria,1G2IN@1117|Cyanobacteria	1117|Cyanobacteria	IQ	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_540863_16	243090.RB10416	2.239e-13	85.0	COG3693@1|root,COG3693@2|Bacteria,2J229@203682|Planctomycetes	203682|Planctomycetes	G	Glycosyl hydrolase family 10	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	Calx-beta,Glyco_hydro_10
CMS3_k127_540863_6	1283287.KB822588_gene1157	6.029e-59	235.0	COG3087@1|root,COG3211@1|root,COG3087@2|Bacteria,COG3211@2|Bacteria	2|Bacteria	O	Phosphatase	phoX	-	-	ko:K01932,ko:K03531,ko:K03980,ko:K07093	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01011,ko02000,ko02048,ko03036,ko04812	2.A.66.4	-	-	DUF839,SPOR
CMS3_k127_540863_10	1206732.BAGD01000278_gene6348	9.793e-26	112.0	COG0778@1|root,COG0778@2|Bacteria,2IPN9@201174|Actinobacteria,4G1KT@85025|Nocardiaceae	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS3_k127_5440418_2	1122247.C731_3634	3.793e-78	266.0	COG1932@1|root,COG1932@2|Bacteria,2GKYK@201174|Actinobacteria,232BR@1762|Mycobacteriaceae	201174|Actinobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
CMS3_k127_5440418_0	1385515.N791_07270	3.31e-152	497.0	COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria	1224|Proteobacteria	I	myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
CMS3_k127_5440418_6	1223542.GM1_007_00220	3.512e-18	94.0	COG0583@1|root,COG0583@2|Bacteria,2GK13@201174|Actinobacteria,4GB5N@85026|Gordoniaceae	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
CMS3_k127_5440418_3	118166.JH976537_gene890	1.464e-36	143.0	COG2062@1|root,COG2062@2|Bacteria,1G74G@1117|Cyanobacteria	1117|Cyanobacteria	T	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
CMS3_k127_5440418_1	196367.JNFG01000020_gene4843	1.9e-106	357.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2VIVJ@28216|Betaproteobacteria,1KC20@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Beta-eliminating lyase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
CMS3_k127_5440418_4	331869.BAL199_04239	1.209e-30	132.0	COG0346@1|root,COG0346@2|Bacteria,1MZT5@1224|Proteobacteria,2U4GS@28211|Alphaproteobacteria,4BQXY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
CMS3_k127_5440418_5	1125863.JAFN01000001_gene2742	7.008e-26	110.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42P0M@68525|delta/epsilon subdivisions,2WJMC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.1,6.2.1.32	ko:K01895,ko:K08295	ko00010,ko00620,ko00627,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00627,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R00982,R01354	RC00004,RC00012,RC00043,RC00070,RC00174,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_5479138_9	322710.Avin_04470	5.1e-25	108.0	COG3640@1|root,COG3640@2|Bacteria,1RB02@1224|Proteobacteria,1SGMS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	CobQ/CobB/MinD/ParA nucleotide binding domain	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
CMS3_k127_5479138_4	868131.MSWAN_1931	7.252e-61	220.0	COG3640@1|root,arCOG00587@2157|Archaea,2XT61@28890|Euryarchaeota	28890|Euryarchaeota	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
CMS3_k127_5479138_6	477974.Daud_0108	1.945e-54	199.0	COG1810@1|root,COG1905@1|root,COG1810@2|Bacteria,COG1905@2|Bacteria,1V737@1239|Firmicutes,24HFB@186801|Clostridia,261VF@186807|Peptococcaceae	186801|Clostridia	C	PFAM Respiratory-chain NADH dehydrogenase 24 Kd subunit	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS3_k127_5479138_5	865861.AZSU01000006_gene1437	6.809e-57	218.0	COG1785@1|root,COG1785@2|Bacteria,1TQCI@1239|Firmicutes,248GG@186801|Clostridia,36GQQ@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
CMS3_k127_5479138_0	554065.XP_005849246.1	1.401e-188	599.0	COG4992@1|root,KOG1401@2759|Eukaryota,37NS6@33090|Viridiplantae,34GPP@3041|Chlorophyta	2759|Eukaryota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
CMS3_k127_5479138_7	1340434.AXVA01000004_gene2790	9.91e-46	180.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,4HA0E@91061|Bacilli,1ZDF1@1386|Bacillus	91061|Bacilli	E	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
CMS3_k127_5479138_10	1121091.AUMP01000031_gene1438	4.41e-21	107.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,4HA8B@91061|Bacilli	91061|Bacilli	E	Saccharopine dehydrogenase	LYS1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
CMS3_k127_5479138_2	1157637.KB892115_gene4639	6.454e-119	402.0	COG2508@1|root,COG2508@2|Bacteria,2GW2W@201174|Actinobacteria	201174|Actinobacteria	QT	Transcriptional regulator	-	-	-	ko:K09684	-	-	-	-	ko00000,ko03000	-	-	-	HTH_30,PucR
CMS3_k127_5479138_1	647113.Metok_1158	5.723e-127	420.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,23QNJ@183939|Methanococci	183939|Methanococci	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
CMS3_k127_5479138_3	1125863.JAFN01000001_gene983	8.965e-71	261.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,42Q1H@68525|delta/epsilon subdivisions,2WK7W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM MOFRL domain protein	Glyctk	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
CMS3_k127_5479138_8	1150599.MPHLEI_19160	2.926e-44	172.0	COG0687@1|root,COG0687@2|Bacteria,2HSPH@201174|Actinobacteria,23DCN@1762|Mycobacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
CMS3_k127_5494341_5	711393.AYRX01000017_gene3081	1.069e-98	327.0	COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria	201174|Actinobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
CMS3_k127_5494341_1	485916.Dtox_0766	2.989e-147	481.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,260XG@186807|Peptococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
CMS3_k127_5494341_0	118163.Ple7327_0971	1.119e-161	522.0	COG0154@1|root,COG0154@2|Bacteria,1G0HS@1117|Cyanobacteria,3VNJR@52604|Pleurocapsales	1117|Cyanobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS3_k127_5494341_8	446471.Xcel_2395	1.675e-22	99.0	COG0721@1|root,COG0721@2|Bacteria,2IQJN@201174|Actinobacteria,4F4P4@85017|Promicromonosporaceae	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
CMS3_k127_5494341_7	1122247.C731_1633	1.253e-58	214.0	COG2364@1|root,COG2364@2|Bacteria,2GKA1@201174|Actinobacteria,235BF@1762|Mycobacteriaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5494341_6	266117.Rxyl_0072	6.72e-85	295.0	COG0624@1|root,COG0624@2|Bacteria,2GK09@201174|Actinobacteria,4CP61@84995|Rubrobacteria	84995|Rubrobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS3_k127_5494341_4	502025.Hoch_5272	3.185e-99	331.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,42SPQ@68525|delta/epsilon subdivisions,2WPX1@28221|Deltaproteobacteria,2YWQX@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
CMS3_k127_5494341_3	42256.RradSPS_2674	1.088e-102	346.0	COG0436@1|root,COG0436@2|Bacteria,2GJMI@201174|Actinobacteria,4CP8N@84995|Rubrobacteria	84995|Rubrobacteria	E	Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_5494341_2	710696.Intca_3240	1.667e-114	383.0	COG0737@1|root,COG0737@2|Bacteria,2GKC3@201174|Actinobacteria,4FEPR@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
CMS3_k127_5511699_6	1463821.JOGR01000012_gene4072	0.0008318	51.0	COG2339@1|root,COG2339@2|Bacteria,2GKR5@201174|Actinobacteria,4EYHJ@85014|Glycomycetales	201174|Actinobacteria	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
CMS3_k127_5511699_0	215803.DB30_7204	0.0	1262.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,42YZ6@68525|delta/epsilon subdivisions,2WU2X@28221|Deltaproteobacteria,2YXQD@29|Myxococcales	28221|Deltaproteobacteria	E	FAD dependent oxidoreductase central domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
CMS3_k127_5511699_1	324602.Caur_2455	5.683e-37	152.0	COG2162@1|root,COG2162@2|Bacteria,2G8H7@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the arylamine N-acetyltransferase family	-	-	2.3.1.118	ko:K00675	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_2
CMS3_k127_5511699_5	1415166.NONO_c14330	1.425e-05	47.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria,4FXBC@85025|Nocardiaceae	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_5511699_4	287986.DV20_11045	6.698e-14	75.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria,4E253@85010|Pseudonocardiales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_5511699_2	1306990.BARG01000030_gene3363	2.154e-32	128.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_5511699_3	1463921.JODF01000057_gene4356	1.596e-29	124.0	COG3629@1|root,COG3629@2|Bacteria,2IAV3@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
CMS3_k127_5521183_1	1313172.YM304_12030	1.496e-160	513.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4CP4J@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_5521183_11	316274.Haur_4578	1.427e-48	188.0	COG1277@1|root,COG1277@2|Bacteria,2GB1V@200795|Chloroflexi,377RP@32061|Chloroflexia	32061|Chloroflexia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
CMS3_k127_5521183_5	316274.Haur_4579	8.223e-95	319.0	COG1131@1|root,COG1131@2|Bacteria,2G5QI@200795|Chloroflexi,376R4@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_5521183_6	933262.AXAM01000100_gene3386	1.631e-72	255.0	COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,42R5A@68525|delta/epsilon subdivisions,2WN5N@28221|Deltaproteobacteria,2MN9Y@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Cation efflux family	catA	-	-	ko:K14696	-	-	-	-	ko00000,ko02000	2.A.4.6	-	-	Cation_efflux,ZT_dimer
CMS3_k127_5521183_14	1380763.BG53_08195	9.081e-34	141.0	COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,4HCQN@91061|Bacilli,26R1M@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
CMS3_k127_5521183_20	390989.JOEG01000011_gene398	5.613e-12	80.0	COG1595@1|root,COG1595@2|Bacteria,2II44@201174|Actinobacteria	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5521183_15	448385.sce2055	3.864e-29	136.0	COG3055@1|root,COG3203@1|root,COG3055@2|Bacteria,COG3203@2|Bacteria,1QA41@1224|Proteobacteria,43DXI@68525|delta/epsilon subdivisions,2X90U@28221|Deltaproteobacteria,2Z1C1@29|Myxococcales	28221|Deltaproteobacteria	M	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5521183_13	33876.JNXY01000041_gene6475	7.046e-38	149.0	COG1595@1|root,COG1595@2|Bacteria,2GM5V@201174|Actinobacteria,4DEI6@85008|Micromonosporales	201174|Actinobacteria	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5521183_24	446462.Amir_4744	8.046e-06	56.0	COG3806@1|root,COG3806@2|Bacteria,2GNHG@201174|Actinobacteria,4E4BZ@85010|Pseudonocardiales	201174|Actinobacteria	T	Anti-sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
CMS3_k127_5521183_0	89187.ISM_03660	1.416e-259	823.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2U2F4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the GcvT family	-	-	1.5.8.4	ko:K00315	ko00260,ko01100,map00260,map01100	-	R01565	RC00181	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
CMS3_k127_5521183_17	1142394.PSMK_22920	5.728e-21	97.0	COG0009@1|root,COG0394@1|root,COG0009@2|Bacteria,COG0394@2|Bacteria,2IX5F@203682|Planctomycetes	203682|Planctomycetes	T	Belongs to the SUA5 family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc,Sua5_yciO_yrdC
CMS3_k127_5521183_9	1397278.AYMV01000019_gene1173	4.989e-53	196.0	COG2071@1|root,COG2071@2|Bacteria,2GQ39@201174|Actinobacteria,4FPWP@85023|Microbacteriaceae	201174|Actinobacteria	S	Peptidase C26	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C26
CMS3_k127_5521183_16	573370.DMR_27290	2.434e-28	118.0	COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42PDY@68525|delta/epsilon subdivisions,2WMD0@28221|Deltaproteobacteria,2M7R7@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
CMS3_k127_5521183_26	1121403.AUCV01000014_gene4615	0.0003381	48.0	COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria,1R6YN@1224|Proteobacteria,42Q4G@68525|delta/epsilon subdivisions,2WJM9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Response_reg
CMS3_k127_5521183_12	1049564.TevJSym_af00930	5.355e-42	164.0	COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria,1RCW6@1224|Proteobacteria,1S3XV@1236|Gammaproteobacteria,1J6BK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Response_reg
CMS3_k127_5521183_21	1121448.DGI_1406	1.346e-10	69.0	COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria,1R6YN@1224|Proteobacteria,42Q4G@68525|delta/epsilon subdivisions,2WJM9@28221|Deltaproteobacteria,2M947@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM Metal-dependent hydrolase HDOD	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Response_reg
CMS3_k127_5521183_18	1191523.MROS_0846	4.998e-16	82.0	COG3437@1|root,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HDOD,HD_5,Response_reg
CMS3_k127_5521183_10	573370.DMR_27270	4.751e-50	192.0	COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,42R6F@68525|delta/epsilon subdivisions,2WN2B@28221|Deltaproteobacteria,2M95Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,Response_reg
CMS3_k127_5521183_23	1394178.AWOO02000072_gene422	7.758e-09	65.0	2E8WU@1|root,3336Z@2|Bacteria,2GR5V@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5521183_8	1120950.KB892708_gene4411	1.708e-67	239.0	COG1938@1|root,COG1938@2|Bacteria,2GK10@201174|Actinobacteria,4DNMH@85009|Propionibacteriales	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
CMS3_k127_5521183_3	1177928.TH2_00330	1.497e-105	376.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2JRKY@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
CMS3_k127_5521183_22	755731.Clo1100_1687	1.916e-10	75.0	COG4447@1|root,COG4447@2|Bacteria,1VCI4@1239|Firmicutes,24CF6@186801|Clostridia,36N4E@31979|Clostridiaceae	186801|Clostridia	M	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS3_k127_5521183_25	1122135.KB893135_gene672	6.547e-05	45.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	SGL
CMS3_k127_5521183_2	1283299.AUKG01000001_gene1980	1.233e-129	423.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4CRTD@84995|Rubrobacteria	84995|Rubrobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
CMS3_k127_5521183_7	1380394.JADL01000001_gene2595	3.411e-71	254.0	COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2U5X1@28211|Alphaproteobacteria,2JRT6@204441|Rhodospirillales	204441|Rhodospirillales	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
CMS3_k127_5521183_4	1267533.KB906738_gene2239	4.06e-102	340.0	COG0626@1|root,COG0626@2|Bacteria,3Y2K5@57723|Acidobacteria,2JHVD@204432|Acidobacteriia	204432|Acidobacteriia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	4.4.1.1	ko:K01758	ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230	M00338	R00782,R01001,R02408,R04770,R04930,R09366	RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
CMS3_k127_5530972_9	222534.KB893671_gene3404	4.91e-15	79.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,4ESJ2@85013|Frankiales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K01992,ko:K18233	ko02010,map02010	M00254,M00634	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	3.A.1,3.A.1.105.2	-	-	ABC2_membrane
CMS3_k127_5530972_0	446470.Snas_1840	2.373e-96	325.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4EZEQ@85014|Glycomycetales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS3_k127_5530972_7	1033730.CAHG01000014_gene1748	5.665e-47	174.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,4DPQ2@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
CMS3_k127_5530972_8	671143.DAMO_2813	2.009e-35	141.0	COG1102@1|root,COG1102@2|Bacteria,2NRB0@2323|unclassified Bacteria	2|Bacteria	F	Cytidylate kinase-like family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Cytidylate_kin2,GAF_2,Pribosyltran
CMS3_k127_5530972_3	1463821.JOGR01000007_gene170	1.208e-89	307.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4EXUB@85014|Glycomycetales	201174|Actinobacteria	E	Aminomethyltransferase folate-binding domain	gcvT	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
CMS3_k127_5530972_4	926554.KI912668_gene5093	1.882e-78	273.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
CMS3_k127_5530972_5	1313172.YM304_33770	1.696e-55	203.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria	201174|Actinobacteria	I	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS3_k127_5530972_2	561175.KB894093_gene3206	7.473e-91	310.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria,4EGXN@85012|Streptosporangiales	201174|Actinobacteria	F	Adenosine/AMP deaminase	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3313c	A_deaminase
CMS3_k127_5530972_1	235985.BBPN01000001_gene1378	9.059e-92	316.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,2NGHU@228398|Streptacidiphilus	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CMS3_k127_5530972_6	351607.Acel_1704	2.892e-47	176.0	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria,4ESYT@85013|Frankiales	201174|Actinobacteria	K	Uncharacterized ACR, COG1678	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
CMS3_k127_5533848_0	880074.BARVI_03030	1.137e-162	536.0	COG1874@1|root,COG1874@2|Bacteria,4PNM8@976|Bacteroidetes,2G105@200643|Bacteroidia,22YWU@171551|Porphyromonadaceae	976|Bacteroidetes	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5545729_6	326427.Cagg_2096	1.662e-108	376.0	COG0022@1|root,COG0022@2|Bacteria,2G5JU@200795|Chloroflexi,374SG@32061|Chloroflexia	32061|Chloroflexia	C	PFAM Transketolase central region	-	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS3_k127_5545729_7	42256.RradSPS_0429	4.531e-100	351.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4CT3Y@84995|Rubrobacteria	84995|Rubrobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
CMS3_k127_5545729_5	997346.HMPREF9374_0320	2.469e-110	368.0	COG0334@1|root,COG0334@2|Bacteria,1TQU2@1239|Firmicutes,4HAB2@91061|Bacilli,27BNG@186824|Thermoactinomycetaceae	91061|Bacilli	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	ldh	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_5545729_22	134676.ACPL_242	5.696e-28	125.0	2BPHM@1|root,32IA4@2|Bacteria,2GM2J@201174|Actinobacteria,4DAHJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5545729_9	997346.HMPREF9374_3746	1.363e-74	264.0	COG4948@1|root,COG4948@2|Bacteria,1TQMS@1239|Firmicutes,4HBMX@91061|Bacilli,27CMB@186824|Thermoactinomycetaceae	91061|Bacilli	H	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
CMS3_k127_5545729_13	1173028.ANKO01000077_gene5349	8.291e-59	219.0	COG2931@1|root,COG2931@2|Bacteria,1G1I0@1117|Cyanobacteria,1H84J@1150|Oscillatoriales	1117|Cyanobacteria	Q	RTX toxins and related Ca2 binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
CMS3_k127_5545729_29	87626.PTD2_04958	0.0002298	44.0	2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5545729_1	1313172.YM304_18000	6.772e-187	588.0	COG0798@1|root,COG0798@2|Bacteria,2GJ4H@201174|Actinobacteria	201174|Actinobacteria	P	arsenical-resistance protein	arsB	-	1.20.4.1	ko:K03325,ko:K03741	-	-	-	-	ko00000,ko01000,ko02000	2.A.59	-	-	SBF
CMS3_k127_5545729_12	314275.MADE_1014900	1.808e-61	220.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1S30T@1236|Gammaproteobacteria,4655K@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Histidine kinase response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Response_reg
CMS3_k127_5545729_18	1385519.N801_05955	3.098e-37	145.0	2F7D1@1|root,33ZU2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5545729_15	1122138.AQUZ01000036_gene5466	2.686e-53	194.0	COG1595@1|root,COG1595@2|Bacteria,2GKFQ@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5545729_24	313589.JNB_15518	2.659e-24	112.0	2F7D1@1|root,33ZU2@2|Bacteria,2ITDT@201174|Actinobacteria,4FISI@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5545729_11	219305.MCAG_01808	9.081e-70	244.0	COG0266@1|root,COG0266@2|Bacteria,2GKUI@201174|Actinobacteria,4D97D@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the FPG family	nei1	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0003906,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0090304,GO:0097159,GO:0097506,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K05522,ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
CMS3_k127_5545729_14	1313172.YM304_09200	1.121e-56	212.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K07552,ko:K19577	-	-	-	-	ko00000,ko02000	2.A.1.2,2.A.1.2.65	-	-	MFS_1,Sugar_tr,Usp
CMS3_k127_5545729_17	1173029.JH980292_gene4085	4.582e-43	162.0	COG4067@1|root,COG4067@2|Bacteria,1G6KI@1117|Cyanobacteria,1HBYC@1150|Oscillatoriales	1117|Cyanobacteria	O	Putative ATP-dependant zinc protease	-	-	-	-	-	-	-	-	-	-	-	-	Zn_protease
CMS3_k127_5545729_0	1313172.YM304_07060	3.301e-198	625.0	COG0189@1|root,COG0189@2|Bacteria,2HGGM@201174|Actinobacteria,4CNDT@84992|Acidimicrobiia	84992|Acidimicrobiia	HJ	Prokaryotic glutathione synthetase, ATP-grasp domain	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
CMS3_k127_5545729_4	1313172.YM304_07050	5.738e-115	378.0	COG3608@1|root,COG3608@2|Bacteria,2HGZV@201174|Actinobacteria,4CP02@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
CMS3_k127_5545729_25	1121116.KB894767_gene2152	4.997e-22	100.0	COG2050@1|root,COG2050@2|Bacteria,1MZRJ@1224|Proteobacteria,2VSE3@28216|Betaproteobacteria,4AEDB@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS3_k127_5545729_28	1298880.AUEV01000001_gene5526	4.169e-08	63.0	COG1522@1|root,COG1522@2|Bacteria,2IMT5@201174|Actinobacteria	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
CMS3_k127_5545729_16	234267.Acid_2204	1.059e-43	168.0	COG0698@1|root,COG0698@2|Bacteria	2|Bacteria	G	galactose-6-phosphate isomerase activity	upp	-	2.4.2.9,5.3.1.6	ko:K00761,ko:K01808	ko00030,ko00051,ko00240,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00240,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R00966,R01056,R09030	RC00063,RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB,UPRTase
CMS3_k127_5545729_10	1120917.AQXM01000057_gene794	1.39e-72	262.0	COG0274@1|root,COG1109@1|root,COG0274@2|Bacteria,COG1109@2|Bacteria,2GJ3Q@201174|Actinobacteria,1W7VY@1268|Micrococcaceae	201174|Actinobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pmmB	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS3_k127_5545729_8	1173029.JH980292_gene4046	3.961e-80	273.0	COG4577@1|root,COG4577@2|Bacteria,1G0GA@1117|Cyanobacteria,1H73J@1150|Oscillatoriales	1117|Cyanobacteria	CQ	PFAM BMC domain	-	-	-	-	-	-	-	-	-	-	-	-	BMC
CMS3_k127_5545729_19	1499967.BAYZ01000012_gene2485	2.203e-35	136.0	COG4577@1|root,COG4577@2|Bacteria,2NRBW@2323|unclassified Bacteria	2|Bacteria	CQ	COGs COG4577 Carbon dioxide concentrating mechanism carboxysome shell protein	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
CMS3_k127_5545729_21	502025.Hoch_5814	3.674e-30	121.0	COG4576@1|root,COG4576@2|Bacteria,1RIK4@1224|Proteobacteria,4362N@68525|delta/epsilon subdivisions,2X9F2@28221|Deltaproteobacteria,2Z246@29|Myxococcales	28221|Deltaproteobacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	-	-	-	-	-	-	-	-	-	-	-	-	EutN_CcmL
CMS3_k127_5545729_3	1499967.BAYZ01000013_gene6421	7.98e-141	462.0	COG1012@1|root,COG1012@2|Bacteria,2NQI9@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde dehydrogenase family	eutE	GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.87	ko:K04021,ko:K13922	ko00620,ko00640,ko01100,ko01120,map00620,map00640,map01100,map01120	-	R00228,R09097	RC00004,RC00184,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh
CMS3_k127_5545729_20	293826.Amet_0267	2.573e-34	138.0	COG4577@1|root,COG4577@2|Bacteria,1UKDS@1239|Firmicutes,24IS5@186801|Clostridia,36DFM@31979|Clostridiaceae	186801|Clostridia	CQ	Microcompartments protein	-	-	-	-	-	-	-	-	-	-	-	-	BMC
CMS3_k127_5545729_26	215803.DB30_2247	1.398e-17	90.0	COG4576@1|root,COG4576@2|Bacteria,1Q0YX@1224|Proteobacteria,434YC@68525|delta/epsilon subdivisions,2WZ99@28221|Deltaproteobacteria,2Z1MJ@29|Myxococcales	28221|Deltaproteobacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	-	-	-	-	-	-	-	-	-	-	-	-	EutN_CcmL
CMS3_k127_5545729_27	215803.DB30_2248	7.872e-12	72.0	COG4576@1|root,COG4576@2|Bacteria,1Q8QH@1224|Proteobacteria,4354D@68525|delta/epsilon subdivisions,2WZFG@28221|Deltaproteobacteria,2Z20V@29|Myxococcales	28221|Deltaproteobacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	-	-	-	-	-	-	-	-	-	-	-	-	EutN_CcmL
CMS3_k127_5545729_2	1121381.JNIV01000003_gene3421	5.645e-142	463.0	COG0579@1|root,COG0579@2|Bacteria,1WMNW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	FAD dependent oxidoreductase	-	-	-	ko:K15736	-	-	-	-	ko00000,ko01000	-	-	-	DAO
CMS3_k127_5547233_1	28444.JODQ01000007_gene5157	8.244e-44	178.0	COG2720@1|root,COG2720@2|Bacteria,2GISH@201174|Actinobacteria,4EGMA@85012|Streptosporangiales	201174|Actinobacteria	V	VanW like protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
CMS3_k127_5547233_6	1123488.ATUF01000002_gene67	1.519e-05	55.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,4D319@85005|Actinomycetales	201174|Actinobacteria	L	RecB family exonuclease	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
CMS3_k127_5547233_0	675635.Psed_0943	1.502e-72	254.0	COG2120@1|root,COG2120@2|Bacteria,2H2NY@201174|Actinobacteria,4DYKF@85010|Pseudonocardiales	201174|Actinobacteria	S	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics	mca	GO:0003674,GO:0005488,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010126,GO:0010127,GO:0016137,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0071704,GO:0098754,GO:1901135,GO:1901657	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
CMS3_k127_5547233_3	1449355.JQNR01000003_gene810	1.483e-32	145.0	COG0699@1|root,COG0699@2|Bacteria,2GJX9@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
CMS3_k127_5547233_2	1095767.CAHD01000233_gene2778	1.485e-34	147.0	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria,4F0FD@85016|Cellulomonadaceae	201174|Actinobacteria	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N,MMR_HSR1
CMS3_k127_5547233_4	469383.Cwoe_3189	1.672e-30	133.0	COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria,4CR9C@84995|Rubrobacteria	84995|Rubrobacteria	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
CMS3_k127_5547233_5	349161.Dred_1555	4.105e-23	103.0	COG0745@1|root,COG0745@2|Bacteria,1VAYR@1239|Firmicutes,255NT@186801|Clostridia	186801|Clostridia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS3_k127_5547233_7	1120972.AUMH01000006_gene1837	0.0002586	47.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4HBS1@91061|Bacilli	91061|Bacilli	C	Belongs to the aldehyde dehydrogenase family	rocA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
CMS3_k127_5553950_10	1122939.ATUD01000008_gene2495	3.071e-21	97.0	COG4221@1|root,COG4221@2|Bacteria,2GP05@201174|Actinobacteria,4CSD7@84995|Rubrobacteria	84995|Rubrobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_5553950_4	504728.K649_13075	7.518e-81	280.0	COG1028@1|root,COG1028@2|Bacteria,1WJW2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	with different specificities (related to short-chain alcohol	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_5553950_8	596152.DesU5LDRAFT_1828	7.082e-32	130.0	COG0454@1|root,COG0456@2|Bacteria,1Q1ZZ@1224|Proteobacteria,42USA@68525|delta/epsilon subdivisions,2WQ2Q@28221|Deltaproteobacteria,2MB9I@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_5553950_5	477641.MODMU_4885	2.218e-73	255.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4ES1V@85013|Frankiales	201174|Actinobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
CMS3_k127_5553950_0	926550.CLDAP_30940	2.655e-162	523.0	COG0076@1|root,COG0076@2|Bacteria,2G7N6@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28,4.1.2.27	ko:K01593,ko:K01634	ko00350,ko00360,ko00380,ko00600,ko00901,ko00950,ko00965,ko01100,ko01110,ko04071,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00600,map00901,map00950,map00965,map01100,map01110,map04071,map04726,map04728,map05030,map05031,map05034	M00037,M00042,M00100	R00685,R00699,R00736,R02080,R02464,R02701,R04909,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
CMS3_k127_5553950_2	1050202.KB913024_gene1468	1.96e-95	323.0	COG0111@1|root,COG0111@2|Bacteria,2I94K@201174|Actinobacteria,407E9@622450|Actinopolysporales	201174|Actinobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS3_k127_5553950_3	1123322.KB904647_gene1699	3.877e-90	306.0	COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria	201174|Actinobacteria	IQ	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
CMS3_k127_5553950_1	1254432.SCE1572_10355	3.451e-153	504.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,43BBS@68525|delta/epsilon subdivisions,2X6QY@28221|Deltaproteobacteria,2YU79@29|Myxococcales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
CMS3_k127_5553950_9	66875.JODY01000021_gene102	3.28e-26	118.0	COG1595@1|root,COG1595@2|Bacteria,2HGII@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5553950_6	1068980.ARVW01000001_gene2852	2.227e-58	216.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,2IH0Y@201174|Actinobacteria,4E30J@85010|Pseudonocardiales	201174|Actinobacteria	FL	Metal binding domain of Ada	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1
CMS3_k127_5553950_11	1151126.AQYI01000003_gene672	3.519e-07	58.0	COG1715@1|root,COG1715@2|Bacteria,2GY47@201174|Actinobacteria	201174|Actinobacteria	V	Restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5561787_2	1385517.N800_04515	4.693e-36	152.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Laminin_G_3,Reprolysin_4,VPEP
CMS3_k127_5561787_0	479434.Sthe_0236	1.85e-51	198.0	COG1840@1|root,COG1840@2|Bacteria,2GBNE@200795|Chloroflexi,27ZCW@189775|Thermomicrobia	2|Bacteria	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
CMS3_k127_5561787_1	1125971.ASJB01000080_gene7213	1.808e-42	180.0	COG1404@1|root,COG1472@1|root,COG3828@1|root,COG4932@1|root,COG1404@2|Bacteria,COG1472@2|Bacteria,COG3828@2|Bacteria,COG4932@2|Bacteria,2I4SB@201174|Actinobacteria,4EE04@85010|Pseudonocardiales	201174|Actinobacteria	GMO	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,PKD,Peptidase_S8,Ricin_B_lectin
CMS3_k127_5561787_3	1385517.N800_04515	1.093e-35	158.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Laminin_G_3,Reprolysin_4,VPEP
CMS3_k127_5561787_4	337191.KTR9_3307	3.07e-07	61.0	COG2815@1|root,COG2815@2|Bacteria,2GRNB@201174|Actinobacteria,4GE71@85026|Gordoniaceae	201174|Actinobacteria	S	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,PASTA
CMS3_k127_5616560_8	1312959.KI914672_gene3455	5.061e-05	52.0	COG4961@1|root,COG4961@2|Bacteria,2IS3K@201174|Actinobacteria	201174|Actinobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
CMS3_k127_5616560_0	935548.KI912159_gene4474	0.0	1261.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,43HUP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the GcvT family	-	-	1.5.8.4	ko:K00315	ko00260,ko01100,map00260,map01100	-	R01565	RC00181	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
CMS3_k127_5616560_7	293826.Amet_3290	4.023e-05	50.0	COG2897@1|root,COG2897@2|Bacteria,1TS7E@1239|Firmicutes,24CNW@186801|Clostridia,36DJP@31979|Clostridiaceae	186801|Clostridia	P	domain protein	-	-	2.8.1.11	ko:K21028	ko04122,map04122	-	R07461	-	ko00000,ko00001,ko01000	-	-	-	Rhodanese
CMS3_k127_5616560_5	742159.HMPREF0004_5121	1.918e-89	302.0	COG1028@1|root,COG1028@2|Bacteria,1PP5H@1224|Proteobacteria,2VJ4Y@28216|Betaproteobacteria,3T2MY@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_5616560_4	177437.HRM2_38480	7.588e-99	336.0	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,42NTX@68525|delta/epsilon subdivisions,2WMFG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	sarcosine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
CMS3_k127_5616560_1	414684.RC1_1843	3.611e-311	962.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TQJR@28211|Alphaproteobacteria,2JQA5@204441|Rhodospirillales	204441|Rhodospirillales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
CMS3_k127_5616560_3	1047013.AQSP01000134_gene1365	3.302e-102	343.0	COG2423@1|root,COG2423@2|Bacteria	2|Bacteria	E	ornithine cyclodeaminase activity	ocd	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
CMS3_k127_5616560_2	1142394.PSMK_09280	5.18e-123	407.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_5616560_6	494419.ALPM01000060_gene2026	3.934e-05	46.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria,1WC7A@1268|Micrococcaceae	201174|Actinobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
CMS3_k127_564735_12	1137268.AZXF01000005_gene3168	4.243e-12	68.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,4EH9B@85012|Streptosporangiales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
CMS3_k127_564735_10	1177179.A11A3_05494	1.941e-26	124.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1XJI1@135619|Oceanospirillales	135619|Oceanospirillales	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
CMS3_k127_564735_7	1449353.JQMQ01000005_gene3307	7.452e-62	220.0	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,2NEBJ@228398|Streptacidiphilus	201174|Actinobacteria	F	Phosphoribosyl transferase domain	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
CMS3_k127_564735_0	570268.ANBB01000033_gene2038	1.412e-224	714.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4EGHW@85012|Streptosporangiales	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CMS3_k127_564735_4	1125863.JAFN01000001_gene2162	6.545e-70	247.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CMS3_k127_564735_9	1229780.BN381_110026	1.666e-30	129.0	2F3QB@1|root,33WH4@2|Bacteria,2H50W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_564735_8	1123386.AUIW01000015_gene531	3.011e-37	147.0	COG0801@1|root,COG0801@2|Bacteria,1WJU9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	TIGRFAM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
CMS3_k127_564735_5	1122939.ATUD01000002_gene1180	4.185e-68	246.0	COG1521@1|root,COG1521@2|Bacteria,2GMRQ@201174|Actinobacteria,4CQ5C@84995|Rubrobacteria	84995|Rubrobacteria	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
CMS3_k127_564735_1	1313172.YM304_28830	2.852e-158	517.0	COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,4CMX2@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
CMS3_k127_564735_2	477184.KYC_19439	5.209e-89	295.0	2DB76@1|root,2Z7JZ@2|Bacteria,1R41X@1224|Proteobacteria,2VMX8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
CMS3_k127_564735_11	114615.BRADO4383	9.512e-25	111.0	2CI52@1|root,2ZC5H@2|Bacteria,1R9WI@1224|Proteobacteria,2UBH1@28211|Alphaproteobacteria,3K483@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_564735_6	1313172.YM304_03920	5.099e-67	241.0	COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4CMZ7@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Polyprenyl synthetase	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
CMS3_k127_564735_3	1123258.AQXZ01000015_gene4717	8.553e-72	243.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4FUFV@85025|Nocardiaceae	201174|Actinobacteria	O	C-terminal, D2-small domain, of ClpB protein	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
CMS3_k127_5650890_10	36809.MAB_3296	1.876e-32	134.0	COG3871@1|root,COG3871@2|Bacteria,2I2QZ@201174|Actinobacteria,234WV@1762|Mycobacteriaceae	201174|Actinobacteria	S	PFAM pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_5650890_9	1411123.JQNH01000001_gene3191	1.62e-45	175.0	COG0431@1|root,COG0431@2|Bacteria,1RAFI@1224|Proteobacteria,2TUBI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NAD(P)H-dependent FMN reductase	-	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
CMS3_k127_5650890_6	1229780.BN381_10280	2.737e-61	232.0	COG2720@1|root,COG2720@2|Bacteria,2GISH@201174|Actinobacteria,3UXFH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	V	VanW like protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
CMS3_k127_5650890_3	1385519.N801_17765	3.483e-86	293.0	COG0648@1|root,COG0648@2|Bacteria,2GJJQ@201174|Actinobacteria,4FEYU@85021|Intrasporangiaceae	201174|Actinobacteria	L	AP endonuclease family 2	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
CMS3_k127_5650890_11	525909.Afer_1944	5.724e-30	125.0	COG0461@1|root,COG0461@2|Bacteria,2HG8J@201174|Actinobacteria,4CN64@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	-
CMS3_k127_5650890_8	502025.Hoch_0349	4.509e-55	200.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	-	-	3.1.3.3,3.1.3.73,5.4.2.11,5.4.2.12	ko:K01834,ko:K02226,ko:K15634,ko:K22305	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003,M00122	R00582,R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
CMS3_k127_5650890_5	935866.JAER01000052_gene2876	4.747e-69	251.0	COG0477@1|root,COG2814@2|Bacteria,2GIR8@201174|Actinobacteria,4DPRP@85009|Propionibacteriales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
CMS3_k127_5650890_13	1410668.JNKC01000001_gene1977	4.451e-09	65.0	2E6HR@1|root,33150@2|Bacteria,1VF6G@1239|Firmicutes,255A1@186801|Clostridia,36T7R@31979|Clostridiaceae	186801|Clostridia	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
CMS3_k127_5650890_7	1236902.ANAS01000005_gene4788	3.288e-56	213.0	COG2113@1|root,COG2113@2|Bacteria,2GP39@201174|Actinobacteria,4ENIK@85012|Streptosporangiales	201174|Actinobacteria	E	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
CMS3_k127_5650890_2	649831.L083_4090	5.855e-108	363.0	COG4175@1|root,COG4175@2|Bacteria,2GJC0@201174|Actinobacteria,4DGRA@85008|Micromonosporales	201174|Actinobacteria	E	TIGRFAM glycine betaine L-proline ABC transporter, ATPase subunit	-	-	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran,CBS
CMS3_k127_5650890_0	284031.JNXD01000002_gene6147	3.909e-121	412.0	COG4176@1|root,COG4176@2|Bacteria,2GKRF@201174|Actinobacteria	201174|Actinobacteria	E	ABC-type proline glycine betaine transport system permease component	proW	-	-	ko:K02001	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
CMS3_k127_5650890_12	1278078.G419_16810	1.074e-17	95.0	COG3187@1|root,COG3187@2|Bacteria,2I9ND@201174|Actinobacteria,4FW9C@85025|Nocardiaceae	201174|Actinobacteria	O	META domain	hslJ	-	-	ko:K03668	-	-	-	-	ko00000	-	-	-	META
CMS3_k127_5650890_4	649638.Trad_0396	8.728e-79	270.0	2C3PP@1|root,2Z954@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5650890_1	649638.Trad_0395	4.438e-108	355.0	COG0115@1|root,COG0115@2|Bacteria,1WIHP@1297|Deinococcus-Thermus	2|Bacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE_1	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CMS3_k127_5651104_6	665571.STHERM_c15920	6.63e-57	203.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
CMS3_k127_5651104_13	887062.HGR_12177	1.127e-11	72.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,2VWDY@28216|Betaproteobacteria,4AG1R@80864|Comamonadaceae	28216|Betaproteobacteria	S	DUF167	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
CMS3_k127_5651104_10	1120948.KB903248_gene4261	1.586e-26	117.0	COG0597@1|root,COG0597@2|Bacteria,2GKRX@201174|Actinobacteria,4E3F6@85010|Pseudonocardiales	201174|Actinobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	GO:0006464,GO:0006497,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0019538,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044419,GO:0051704,GO:0071704,GO:1901564,GO:1901566,GO:1901576	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
CMS3_k127_5651104_5	643648.Slip_0836	3.074e-58	216.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,42JJW@68298|Syntrophomonadaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS3_k127_5651104_2	469383.Cwoe_3478	2.587e-108	370.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria	201174|Actinobacteria	Q	Belongs to the long-chain O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
CMS3_k127_5651104_0	1313172.YM304_19620	0.0	1202.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CMWT@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DNA polymerase alpha chain like domain	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
CMS3_k127_5651104_4	1380394.JADL01000010_gene4202	7.435e-62	224.0	COG2040@1|root,COG2040@2|Bacteria,1QU2A@1224|Proteobacteria,2TS3P@28211|Alphaproteobacteria,2JQ6P@204441|Rhodospirillales	204441|Rhodospirillales	E	Homocysteine S-methyltransferase	-	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
CMS3_k127_5651104_3	1288494.EBAPG3_1550	1.518e-72	267.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,372DJ@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_4,PAS_9,Response_reg
CMS3_k127_5651104_7	1229780.BN381_310066	1.268e-45	180.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria	201174|Actinobacteria	D	anion-transporting ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
CMS3_k127_5651104_9	1121877.JQKF01000016_gene165	8.559e-30	130.0	COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria,4CMZD@84992|Acidimicrobiia	84992|Acidimicrobiia	P	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
CMS3_k127_5651104_12	1121877.JQKF01000027_gene2453	9.45e-13	70.0	2ANAN@1|root,31D8Y@2|Bacteria,2HGVW@201174|Actinobacteria,4CNX0@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5651104_8	1502851.FG93_01462	1.17e-37	149.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2U9GC@28211|Alphaproteobacteria,3JQWH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
CMS3_k127_5651104_1	880526.KE386488_gene925	5.158e-122	396.0	COG0207@1|root,COG0207@2|Bacteria,4NEC2@976|Bacteroidetes,2FM46@200643|Bacteroidia,22U3J@171550|Rikenellaceae	976|Bacteroidetes	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
CMS3_k127_5656537_7	1151119.KB895501_gene2900	1.03e-08	60.0	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
CMS3_k127_5656537_8	1035308.AQYY01000001_gene2018	0.0001057	49.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF836
CMS3_k127_5656537_2	1304865.JAGF01000001_gene3359	5.558e-78	273.0	COG0785@1|root,COG0785@2|Bacteria,2GMXW@201174|Actinobacteria	201174|Actinobacteria	O	cytochrome c biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
CMS3_k127_5656537_6	446466.Cfla_0356	1.048e-26	117.0	COG1225@1|root,COG1225@2|Bacteria,2IGFI@201174|Actinobacteria	201174|Actinobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
CMS3_k127_5656537_3	928724.SacglDRAFT_02966	5.457e-69	241.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria,4E95J@85010|Pseudonocardiales	201174|Actinobacteria	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,DsbD
CMS3_k127_5656537_4	928724.SacglDRAFT_02958	3.604e-62	221.0	COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria,4E3DR@85010|Pseudonocardiales	201174|Actinobacteria	CO	Thiol-disulfide isomerase-like thioredoxin	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
CMS3_k127_5656537_0	68219.JNXI01000040_gene5489	2.875e-86	301.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_5656537_1	1157640.AQWO01000010_gene2792	4.626e-82	283.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_5656537_5	926550.CLDAP_14460	4.983e-34	136.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
CMS3_k127_5687825_8	319795.Dgeo_2227	1.545e-22	114.0	COG0739@1|root,COG0739@2|Bacteria,1WK9B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM Peptidase family M23	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
CMS3_k127_5687825_7	1460634.JCM19037_3596	2.98e-42	177.0	COG5276@1|root,COG5276@2|Bacteria,1UUVN@1239|Firmicutes,4HBJX@91061|Bacilli	91061|Bacilli	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
CMS3_k127_5687825_9	1207076.ALAT01000198_gene1229	1.529e-07	59.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1Z109@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	M	esterase of the alpha-beta hydrolase superfamily	plpD	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
CMS3_k127_5687825_6	304371.MCP_0389	3.218e-54	206.0	arCOG11014@1|root,arCOG11014@2157|Archaea,2XZ0A@28890|Euryarchaeota	2157|Archaea	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
CMS3_k127_5687825_2	134676.ACPL_4726	6.083e-130	442.0	COG1404@1|root,COG1404@2|Bacteria,2IAS7@201174|Actinobacteria,4DHP7@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
CMS3_k127_5687825_10	6183.Smp_171820.2	4.207e-05	51.0	COG0664@1|root,KOG2968@2759|Eukaryota,38ERP@33154|Opisthokonta,3BAG1@33208|Metazoa,3CVZD@33213|Bilateria	33208|Metazoa	I	lysophospholipase activity	sws	GO:0001894,GO:0001895,GO:0001932,GO:0001933,GO:0003008,GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0006469,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0007272,GO:0007275,GO:0007399,GO:0007600,GO:0007606,GO:0007608,GO:0008104,GO:0008150,GO:0008152,GO:0008219,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0012501,GO:0012505,GO:0016020,GO:0016043,GO:0016298,GO:0016787,GO:0016788,GO:0019220,GO:0019222,GO:0019637,GO:0019899,GO:0019900,GO:0019901,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0031984,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0033036,GO:0033673,GO:0034236,GO:0034349,GO:0034613,GO:0042175,GO:0042325,GO:0042326,GO:0042592,GO:0043086,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043549,GO:0044092,GO:0044237,GO:0044238,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045494,GO:0045859,GO:0045936,GO:0046470,GO:0046486,GO:0048519,GO:0048523,GO:0048731,GO:0048856,GO:0048871,GO:0050789,GO:0050790,GO:0050794,GO:0050877,GO:0051018,GO:0051171,GO:0051172,GO:0051174,GO:0051179,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0051402,GO:0051641,GO:0052689,GO:0060249,GO:0060255,GO:0061024,GO:0065007,GO:0065008,GO:0065009,GO:0070727,GO:0070997,GO:0071704,GO:0071840,GO:0071900,GO:0071901,GO:0071944,GO:0072657,GO:0080090,GO:0097164,GO:0098827,GO:1901564,GO:2000479,GO:2000480	3.1.1.5	ko:K14676	ko00564,map00564	-	R02746,R02747,R03416,R03417	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko01000	-	-	-	Patatin,cNMP_binding
CMS3_k127_5687825_0	1048339.KB913029_gene2528	6.934e-169	561.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4ERZ6@85013|Frankiales	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_5687825_3	1313172.YM304_27930	3.012e-106	353.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CNT1@84992|Acidimicrobiia	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_5687825_4	1214242.B446_08540	1.638e-85	290.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_5687825_5	1043493.BBLU01000003_gene2373	1.316e-74	269.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
CMS3_k127_5687825_1	1236902.ANAS01000022_gene187	1.27e-159	516.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,4EH4Z@85012|Streptosporangiales	201174|Actinobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
CMS3_k127_5697267_5	861299.J421_4524	1.575e-100	340.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS3_k127_5697267_1	926550.CLDAP_26270	2.337e-146	471.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
CMS3_k127_5697267_2	391623.TERMP_00016	1.157e-109	365.0	COG1402@1|root,arCOG04536@2157|Archaea	2157|Archaea	S	Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
CMS3_k127_5697267_0	1410620.SHLA_38c000530	3.794e-158	511.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,4B9XR@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_5697267_7	381666.H16_B1070	2.992e-80	275.0	COG2021@1|root,COG2021@2|Bacteria,1QVBR@1224|Proteobacteria,2WHMR@28216|Betaproteobacteria,1KAIW@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Serine hydrolase (FSH1)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_5697267_11	1265505.ATUG01000002_gene2469	8.67e-50	187.0	2C3PP@1|root,2Z954@2|Bacteria,1MXGR@1224|Proteobacteria,42V57@68525|delta/epsilon subdivisions,2WRWG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Branched-chain amino acid aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5697267_9	742735.HMPREF9467_04544	2.745e-77	272.0	COG1063@1|root,COG1063@2|Bacteria,1UI0K@1239|Firmicutes,24ATX@186801|Clostridia,220EH@1506553|Lachnoclostridium	186801|Clostridia	E	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_5697267_10	138119.DSY0967	1.406e-55	205.0	COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,24R48@186801|Clostridia,2637S@186807|Peptococcaceae	186801|Clostridia	S	PFAM Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
CMS3_k127_5697267_4	1218076.BAYB01000049_gene5957	9.466e-106	364.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJJV@28216|Betaproteobacteria,1K7HU@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_5697267_6	1205680.CAKO01000002_gene3120	1.07e-96	336.0	COG2421@1|root,COG2421@2|Bacteria,1MXKY@1224|Proteobacteria,2TSVA@28211|Alphaproteobacteria,2JR7H@204441|Rhodospirillales	204441|Rhodospirillales	C	Acetamidase/Formamidase family	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
CMS3_k127_5697267_3	118166.JH976537_gene4234	4.454e-106	377.0	COG3211@1|root,COG4222@1|root,COG3211@2|Bacteria,COG4222@2|Bacteria,1GQ3P@1117|Cyanobacteria,1HI0H@1150|Oscillatoriales	1117|Cyanobacteria	Q	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	Alk_phosphatase,Exo_endo_phos,GDPD,HemolysinCabind,Phytase-like
CMS3_k127_5697267_16	1122182.KB903813_gene2186	3.613e-05	50.0	COG2128@1|root,COG2128@2|Bacteria,2I829@201174|Actinobacteria,4DKN3@85008|Micromonosporales	201174|Actinobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	CMD
CMS3_k127_5697267_17	397278.JOJN01000002_gene601	0.0009181	45.0	COG2128@1|root,COG2128@2|Bacteria,2HZX3@201174|Actinobacteria,4DUDY@85009|Propionibacteriales	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5697267_15	43354.JOIJ01000001_gene396	2.286e-06	60.0	COG3147@1|root,COG3147@2|Bacteria,2GYC2@201174|Actinobacteria,4ECZ4@85010|Pseudonocardiales	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5697267_14	390989.JOEG01000004_gene3789	1.311e-06	56.0	COG1595@1|root,COG1595@2|Bacteria,2GKDD@201174|Actinobacteria,4DDN5@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5697267_8	96561.Dole_0567	1.868e-78	292.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,2MI1W@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
CMS3_k127_5697267_12	1123258.AQXZ01000019_gene2736	6.992e-39	153.0	COG0347@1|root,COG0347@2|Bacteria,2IKN1@201174|Actinobacteria,4G17M@85025|Nocardiaceae	201174|Actinobacteria	K	nitrogen regulatory protein P-II	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
CMS3_k127_5697267_13	1304885.AUEY01000011_gene1748	7.996e-31	124.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42MFT@68525|delta/epsilon subdivisions,2WIXC@28221|Deltaproteobacteria,2MHRV@213118|Desulfobacterales	28221|Deltaproteobacteria	P	TIGRFAM ammonium transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
CMS3_k127_5730313_12	395961.Cyan7425_4434	5.409e-06	56.0	28P9J@1|root,2ZC30@2|Bacteria,1G5N2@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5730313_4	869210.Marky_1177	4.032e-70	251.0	COG0120@1|root,COG0120@2|Bacteria,1WIR4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
CMS3_k127_5730313_6	1123059.KB823011_gene1419	2.904e-49	179.0	COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,2U9GG@28211|Alphaproteobacteria,43Y20@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	MaoC like domain	nodN	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
CMS3_k127_5730313_0	1168065.DOK_03073	8.498e-175	562.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1J55J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_5730313_2	876044.IMCC3088_2705	7.279e-105	349.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,1SYCA@1236|Gammaproteobacteria,1J8PP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_5730313_11	81824.XP_001750646.1	3.474e-10	72.0	KOG1217@1|root,KOG4729@1|root,KOG1217@2759|Eukaryota,KOG4729@2759|Eukaryota	2759|Eukaryota	O	carbohydrate binding	SUSD1	GO:0003674,GO:0005488,GO:0005515	1.1.5.3	ko:K00111,ko:K04593,ko:K19904	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000,ko04030,ko04131	-	-	-	EGF_CA,Gal_Lectin,Sushi,TIL
CMS3_k127_5730313_8	1137268.AZXF01000001_gene238	3.138e-28	130.0	COG0642@1|root,COG2205@2|Bacteria,2GNUQ@201174|Actinobacteria,4EG9P@85012|Streptosporangiales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_5730313_7	518766.Rmar_1125	1.207e-43	181.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,4NER4@976|Bacteroidetes,1FJZ0@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Bacterial sugar transferase	-	-	-	ko:K13012	-	-	-	-	ko00000,ko01005	-	-	-	Bac_transf,CoA_binding_3
CMS3_k127_5730313_9	203119.Cthe_2077	1.303e-24	110.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24P0N@186801|Clostridia	186801|Clostridia	S	CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
CMS3_k127_5730313_1	797209.ZOD2009_20967	1.057e-151	508.0	COG0531@1|root,arCOG00009@2157|Archaea,2XTX6@28890|Euryarchaeota,23S2B@183963|Halobacteria	183963|Halobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
CMS3_k127_5730313_3	292459.STH590	5.388e-87	289.0	COG2224@1|root,COG2224@2|Bacteria,1TP1U@1239|Firmicutes	1239|Firmicutes	C	Isocitrate lyase	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
CMS3_k127_5771965_3	391595.RLO149_c037000	5.058e-23	102.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS3_k127_5771965_0	1173026.Glo7428_4866	3.308e-153	498.0	COG1473@1|root,COG1473@2|Bacteria,1G01G@1117|Cyanobacteria	2|Bacteria	S	PFAM Peptidase family M20 M25 M40	yxeP_1	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_5771965_2	1121875.KB907546_gene2192	6.12e-48	183.0	2C0ZU@1|root,32R7S@2|Bacteria,4P4KK@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5771965_1	223926.28806353	8.208e-52	189.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria,1XVZK@135623|Vibrionales	135623|Vibrionales	E	Peptidase dimerisation domain	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS3_k127_5796738_0	1232410.KI421418_gene2233	3.169e-260	807.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,42P36@68525|delta/epsilon subdivisions,2WKGD@28221|Deltaproteobacteria,43TSV@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Predicted Permease Membrane Region	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
CMS3_k127_5805290_0	463191.SSEG_06046	5.764e-74	266.0	COG1073@1|root,COG5297@1|root,COG1073@2|Bacteria,COG5297@2|Bacteria,2GJXK@201174|Actinobacteria	201174|Actinobacteria	G	Alpha-L-arabinofuranosidase B, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	AbfB,ArabFuran-catal,RicinB_lectin_2
CMS3_k127_584139_0	713586.KB900536_gene2659	2.366e-119	395.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3
CMS3_k127_584139_1	1237149.C900_00913	0.0006156	49.0	COG0666@1|root,COG0666@2|Bacteria,4NEYY@976|Bacteroidetes,47MVD@768503|Cytophagia	976|Bacteroidetes	U	Ankyrin repeats (3 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,Lipocalin_5,SecA_DEAD
CMS3_k127_5855809_0	1043205.AFYF01000071_gene2243	7.631e-29	118.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4FFP0@85021|Intrasporangiaceae	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS3_k127_5859354_5	353496.LBU_0273	5.536e-21	96.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli,3F3N2@33958|Lactobacillaceae	91061|Bacilli	L	hydrolase, TatD family	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
CMS3_k127_5859354_3	1313172.YM304_33050	4.707e-55	204.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4CN5A@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	-	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
CMS3_k127_5859354_4	1121472.AQWN01000007_gene1167	7.804e-32	139.0	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,261HE@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
CMS3_k127_5859354_2	106370.Francci3_3961	1.903e-56	206.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4ERCR@85013|Frankiales	201174|Actinobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
CMS3_k127_5859354_1	525909.Afer_1597	5.374e-112	371.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,4CMVQ@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
CMS3_k127_5859354_0	1128421.JAGA01000001_gene2203	1.953e-131	434.0	COG4579@1|root,COG4579@2|Bacteria	2|Bacteria	F	[isocitrate dehydrogenase (NADP+)] phosphatase activity	aceK	GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
CMS3_k127_5880515_3	1048339.KB913029_gene4841	2.891e-24	109.0	COG0799@1|root,COG0799@2|Bacteria,2IKZ3@201174|Actinobacteria,4ESRQ@85013|Frankiales	201174|Actinobacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
CMS3_k127_5880515_5	644966.Tmar_2199	5.576e-06	58.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,24AAY@186801|Clostridia,3WD9K@538999|Clostridiales incertae sedis	186801|Clostridia	K	Cell envelope-related transcriptional attenuator domain	lytR	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
CMS3_k127_5880515_1	552811.Dehly_1340	3.183e-40	158.0	COG1057@1|root,COG1057@2|Bacteria,2G6MY@200795|Chloroflexi,34D3W@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
CMS3_k127_5880515_4	321327.CYA_1627	7.159e-12	74.0	COG4942@1|root,COG4942@2|Bacteria,1G2JU@1117|Cyanobacteria,1H467@1129|Synechococcus	1117|Cyanobacteria	D	peptidase	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
CMS3_k127_5880515_2	479432.Sros_1560	1.469e-24	108.0	COG0745@1|root,COG0745@2|Bacteria,2I2Z1@201174|Actinobacteria,4EJHI@85012|Streptosporangiales	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS3_k127_5880515_0	1313172.YM304_23520	6e-90	306.0	COG3552@1|root,COG3825@1|root,COG3552@2|Bacteria,COG3825@2|Bacteria,2GNTS@201174|Actinobacteria,4CMU1@84992|Acidimicrobiia	84992|Acidimicrobiia	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
CMS3_k127_5889995_4	1211815.CBYP010000042_gene2358	9.927e-136	444.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4ES2Q@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM 2-oxoglutarate dehydrogenase, E1	kgd	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
CMS3_k127_5889995_1	1229780.BN381_60088	3.235e-253	801.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,2GJ7M@201174|Actinobacteria,3UX6A@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	4Fe-4S dicluster domain	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
CMS3_k127_5889995_5	35754.JNYJ01000046_gene3102	5.468e-120	411.0	COG1520@1|root,COG1520@2|Bacteria,2I9S4@201174|Actinobacteria,4D97G@85008|Micromonosporales	201174|Actinobacteria	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS3_k127_5889995_2	1385519.N801_15180	7.133e-156	507.0	COG2232@1|root,COG2232@2|Bacteria,2HPI0@201174|Actinobacteria,4FK2A@85021|Intrasporangiaceae	201174|Actinobacteria	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
CMS3_k127_5889995_13	926560.KE387023_gene2224	8.102e-47	177.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	eryCVI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0046983	2.1.1.234	ko:K13311,ko:K13326,ko:K21335	ko00523,ko01130,map00523,map01130	M00797,M00800	R06427,R11045,R11476	RC00003,RC01515,RC02262	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
CMS3_k127_5889995_14	1414719.CBYN010000001_gene907	2.08e-28	123.0	COG1842@1|root,COG1842@2|Bacteria,2GJGD@201174|Actinobacteria,22KB8@1653|Corynebacteriaceae	201174|Actinobacteria	KT	Phage shock protein A (IM30), suppresses sigma54-dependent transcription	pspA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044464,GO:0071944	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
CMS3_k127_5889995_10	44060.JODL01000001_gene2941	2.306e-68	243.0	COG0506@1|root,COG0506@2|Bacteria,2GJTK@201174|Actinobacteria	201174|Actinobacteria	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
CMS3_k127_5889995_11	1032480.MLP_48140	2.908e-59	215.0	COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,4DNEJ@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
CMS3_k127_5889995_3	1449080.JQMV01000003_gene1002	4.655e-148	485.0	COG1541@1|root,COG1541@2|Bacteria,1WJ2G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006082,GO:0006725,GO:0006805,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0017076,GO:0019439,GO:0019748,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0047475,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0097159,GO:0097367,GO:0098754,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
CMS3_k127_5889995_12	1120948.KB903217_gene1626	2.268e-47	187.0	COG4585@1|root,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4DXQC@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	tcsS3	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,PspC
CMS3_k127_5889995_8	1121272.KB903250_gene2900	1.979e-81	281.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4D9AV@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	tcsR3	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_5889995_7	521011.Mpal_2572	2.59e-86	293.0	COG4063@1|root,arCOG03221@2157|Archaea	2157|Archaea	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrA-2	-	2.1.1.86	ko:K00577	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrA
CMS3_k127_5889995_9	357808.RoseRS_3665	1.201e-72	268.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
CMS3_k127_5889995_6	1131814.JAFO01000001_gene1546	3.181e-104	355.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TU1G@28211|Alphaproteobacteria,3F0F7@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_5889995_0	570967.JMLV01000012_gene3173	1.612e-284	895.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TSAP@28211|Alphaproteobacteria,2JRAB@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.2.3	ko:K07812,ko:K08351	ko00780,ko01100,map00780,map01100	-	R10127	RC03056	ko00000,ko00001,ko01000,ko02000	5.A.3.4	-	-	Molybdopterin,Molydop_binding,TAT_signal
CMS3_k127_5890610_4	469371.Tbis_1374	1.039e-87	296.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GIWJ@201174|Actinobacteria,4DXCJ@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	GO:0005575,GO:0005576,GO:0008150,GO:0040007	3.5.4.25,4.1.99.12	ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1415	DHBP_synthase,GTP_cyclohydro2
CMS3_k127_5890610_9	1896.JOAU01000013_gene1969	1.203e-59	225.0	COG0307@1|root,COG0307@2|Bacteria,2GKC5@201174|Actinobacteria	201174|Actinobacteria	H	riboflavin synthase, alpha	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
CMS3_k127_5890610_5	1033802.SSPSH_002748	4.52e-72	258.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008703,GO:0008835,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.193,3.5.4.26	ko:K01498,ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	iB21_1397.B21_00366,iECBD_1354.ECBD_3247,iECB_1328.ECB_00362,iECD_1391.ECD_00362,iECED1_1282.ECED1_0437,iECNA114_1301.ECNA114_0391,iECSF_1327.ECSF_0374,iEcolC_1368.EcolC_3219,iLF82_1304.LF82_1880,iNRG857_1313.NRG857_01945,iYL1228.KPN_00366,ic_1306.c0524	RibD_C,dCMP_cyt_deam_1
CMS3_k127_5890610_3	390989.JOEG01000007_gene596	3.943e-95	321.0	COG2199@1|root,COG3706@2|Bacteria,2IABQ@201174|Actinobacteria,4D9W3@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
CMS3_k127_5890610_7	1121468.AUBR01000005_gene42	8.981e-61	223.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,42EWH@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Ribulose-phosphate 3-epimerase	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
CMS3_k127_5890610_1	1122221.JHVI01000013_gene2784	8.559e-109	359.0	COG2326@1|root,COG2326@2|Bacteria,1WKEJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
CMS3_k127_5890610_10	1035308.AQYY01000001_gene2668	3.241e-59	220.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia,260EN@186807|Peptococcaceae	186801|Clostridia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
CMS3_k127_5890610_12	1121877.JQKF01000023_gene2244	1.066e-49	181.0	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,4CN7F@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
CMS3_k127_5890610_14	1089553.Tph_c14300	1.777e-32	145.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,42EMV@68295|Thermoanaerobacterales	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
CMS3_k127_5890610_2	1313172.YM304_20510	6.701e-100	339.0	COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,4CMYE@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
CMS3_k127_5890610_16	1313172.YM304_20500	4.076e-16	86.0	COG1758@1|root,COG1758@2|Bacteria,2HG9P@201174|Actinobacteria,4CN82@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
CMS3_k127_5890610_11	321332.CYB_0056	2.876e-53	195.0	COG0194@1|root,COG0194@2|Bacteria,1G515@1117|Cyanobacteria,1GZ3I@1129|Synechococcus	1117|Cyanobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
CMS3_k127_5890610_15	1121353.H924_07605	5.829e-30	121.0	COG0099@1|root,COG0099@2|Bacteria,2IKPU@201174|Actinobacteria,22NIS@1653|Corynebacteriaceae	201174|Actinobacteria	J	integration host factor	mihF	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5890610_13	1121033.AUCF01000005_gene5376	2.231e-47	179.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2TTB3@28211|Alphaproteobacteria,2JRPW@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
CMS3_k127_5890610_8	767817.Desgi_3049	4.553e-60	223.0	COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,248CQ@186801|Clostridia,260Y3@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
CMS3_k127_5890610_0	351607.Acel_1298	0.0	1238.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4ERGS@85013|Frankiales	201174|Actinobacteria	F	Belongs to the CarB family	carB	GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
CMS3_k127_5890610_6	867845.KI911784_gene1947	2.037e-69	242.0	COG0505@1|root,COG0505@2|Bacteria,2G5S1@200795|Chloroflexi,3755X@32061|Chloroflexia	32061|Chloroflexia	F	TIGRFAM carbamoyl-phosphate synthase, small subunit	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
CMS3_k127_5915076_2	263358.VAB18032_20545	4.965e-32	146.0	COG0577@1|root,COG0577@2|Bacteria,2H997@201174|Actinobacteria,4DBGI@85008|Micromonosporales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
CMS3_k127_5915076_0	1458462.JNLK01000001_gene1140	1.458e-67	239.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,27KAQ@186928|unclassified Lachnospiraceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_5915076_1	543632.JOJL01000007_gene5544	3.393e-50	188.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4DAEI@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_5927313_17	469383.Cwoe_5927	3.884e-25	108.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4CQ40@84995|Rubrobacteria	84995|Rubrobacteria	C	Cytochrome b	-	-	-	ko:K03887	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_B
CMS3_k127_5927313_18	234267.Acid_6209	1.219e-22	105.0	COG0723@1|root,COG0723@2|Bacteria,3Y7YJ@57723|Acidobacteria	57723|Acidobacteria	C	Rieske [2Fe-2S] domain	-	-	-	ko:K03886	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
CMS3_k127_5927313_9	383372.Rcas_0843	2.065e-74	253.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi,3764A@32061|Chloroflexia	32061|Chloroflexia	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CMS3_k127_5927313_1	644966.Tmar_0545	3.676e-223	717.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,3WD5H@538999|Clostridiales incertae sedis	186801|Clostridia	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain	-	-	1.17.1.4,1.2.5.3	ko:K03520,ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
CMS3_k127_5927313_11	479434.Sthe_1400	2.022e-63	233.0	COG1319@1|root,COG1319@2|Bacteria,2G60Y@200795|Chloroflexi,27XP9@189775|Thermomicrobia	189775|Thermomicrobia	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
CMS3_k127_5927313_16	751944.HALDL1_02160	1.413e-26	126.0	COG0784@1|root,COG2203@1|root,arCOG02333@2157|Archaea,arCOG02369@2157|Archaea,2XST7@28890|Euryarchaeota,23S1Y@183963|Halobacteria	183963|Halobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
CMS3_k127_5927313_8	2002.JOEQ01000001_gene4746	2.692e-76	274.0	COG4191@1|root,COG4191@2|Bacteria,2I3H5@201174|Actinobacteria	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_5927313_6	1246995.AFR_10220	3.498e-84	285.0	COG0745@1|root,COG0745@2|Bacteria,2GMVN@201174|Actinobacteria,4D8W6@85008|Micromonosporales	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_5927313_0	1123024.AUII01000015_gene3726	9.652e-273	863.0	COG0466@1|root,COG0466@2|Bacteria,2GK9D@201174|Actinobacteria,4DYVW@85010|Pseudonocardiales	201174|Actinobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
CMS3_k127_5927313_14	309807.SRU_0882	1.479e-54	201.0	COG0566@1|root,COG0566@2|Bacteria,4NFH3@976|Bacteroidetes,1FJBJ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA	trmH	-	2.1.1.34	ko:K00556	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
CMS3_k127_5927313_15	1123057.P872_06335	2.812e-46	181.0	COG0823@1|root,COG0823@2|Bacteria,4PME8@976|Bacteroidetes,47Y2Q@768503|Cytophagia	976|Bacteroidetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5927313_3	390989.JOEG01000001_gene5220	1.45e-154	499.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4D8NU@85008|Micromonosporales	201174|Actinobacteria	E	Peptidase dimerisation domain	argE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_5927313_5	216594.MMAR_0112	4.908e-122	397.0	COG0596@1|root,COG0596@2|Bacteria,2I99I@201174|Actinobacteria,2350U@1762|Mycobacteriaceae	201174|Actinobacteria	S	Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons	dhaA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009410,GO:0009987,GO:0016020,GO:0016787,GO:0016824,GO:0018786,GO:0019120,GO:0030312,GO:0042178,GO:0042197,GO:0042206,GO:0042221,GO:0044237,GO:0044248,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071466,GO:0071704,GO:0071944,GO:1901575	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
CMS3_k127_5927313_19	1312959.KI914653_gene515	1.577e-17	88.0	COG3832@1|root,COG3832@2|Bacteria,2IN0A@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
CMS3_k127_5927313_2	1089550.ATTH01000001_gene162	1.011e-172	555.0	COG0364@1|root,COG0364@2|Bacteria,4NE59@976|Bacteroidetes,1FIS5@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
CMS3_k127_5927313_4	84531.JMTZ01000030_gene152	1.946e-127	414.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,1T1KM@1236|Gammaproteobacteria,1X4EG@135614|Xanthomonadales	135614|Xanthomonadales	G	6-phosphogluconate dehydrogenase	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
CMS3_k127_5927313_7	1449976.KALB_1497	5.213e-82	278.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4E84S@85010|Pseudonocardiales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07669,ko:K07672	ko02020,map02020	M00460,M00463	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_5927313_10	1380390.JIAT01000013_gene221	1.543e-73	271.0	COG0642@1|root,COG2205@2|Bacteria,2GM17@201174|Actinobacteria,4CREI@84995|Rubrobacteria	84995|Rubrobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS3_k127_5927313_20	68223.JNZY01000039_gene4473	6.828e-11	67.0	2DM0Y@1|root,318KY@2|Bacteria,2IMIX@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF1992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1992
CMS3_k127_5927313_13	349124.Hhal_1267	1.411e-56	213.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,1RPKA@1236|Gammaproteobacteria,1WXPP@135613|Chromatiales	135613|Chromatiales	G	pfam mofrl	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
CMS3_k127_5927313_12	926569.ANT_04400	2.493e-61	224.0	COG0454@1|root,COG1247@1|root,COG0456@2|Bacteria,COG1247@2|Bacteria,2G6N6@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_5996150_16	1123024.AUII01000019_gene3963	7.227e-53	190.0	COG1878@1|root,COG1878@2|Bacteria	2|Bacteria	S	arylformamidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
CMS3_k127_5996150_18	1380355.JNIJ01000008_gene1879	6.992e-43	163.0	COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,2TU74@28211|Alphaproteobacteria,3JVQG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_5996150_12	1187851.A33M_2608	3.054e-67	241.0	COG2084@1|root,COG2084@2|Bacteria,1R889@1224|Proteobacteria,2TUEY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
CMS3_k127_5996150_9	1231391.AMZF01000018_gene1831	2.286e-78	273.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2VPKM@28216|Betaproteobacteria,3T38J@506|Alcaligenaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
CMS3_k127_5996150_25	221288.JH992901_gene2572	2.447e-17	89.0	COG2267@1|root,COG2267@2|Bacteria,1G4F2@1117|Cyanobacteria,1JHUI@1189|Stigonemataceae	1117|Cyanobacteria	I	TAP-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
CMS3_k127_5996150_31	1173026.Glo7428_3910	5.62e-10	63.0	COG2267@1|root,COG2267@2|Bacteria,1G4F2@1117|Cyanobacteria	1117|Cyanobacteria	I	COGs COG0596 hydrolase or acyltransferase (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
CMS3_k127_5996150_17	1242864.D187_000281	2.135e-48	195.0	COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,42WQU@68525|delta/epsilon subdivisions,2WTEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Inosine-uridine preferring nucleoside hydrolase	-	-	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
CMS3_k127_5996150_20	1123060.JONP01000015_gene4343	2.215e-36	153.0	COG0673@1|root,COG0673@2|Bacteria,1N0VK@1224|Proteobacteria,2VFQZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_5996150_8	543632.JOJL01000020_gene629	3.688e-79	279.0	COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
CMS3_k127_5996150_32	710111.FraQA3DRAFT_6231	1.111e-09	71.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GMN4@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
CMS3_k127_5996150_38	1056816.JAFQ01000004_gene5594	0.0009085	52.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GMN4@201174|Actinobacteria,4FUX8@85025|Nocardiaceae	201174|Actinobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007,ko:K21787	ko00333,ko00620,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00333,map00620,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00374,M00837,M00838	R00199,R11662,R11673	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS3_k127_5996150_0	1342299.Z947_120	4.003e-278	865.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Hydrolase CocE NonD family	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS3_k127_5996150_7	66874.JOFS01000008_gene2255	4.863e-85	289.0	COG0491@1|root,COG0491@2|Bacteria,2GJ6X@201174|Actinobacteria	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_5996150_21	68570.DC74_1275	4.217e-36	150.0	COG2423@1|root,COG2423@2|Bacteria	2|Bacteria	E	ornithine cyclodeaminase activity	-	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
CMS3_k127_5996150_10	285535.JOEY01000073_gene9814	2.575e-72	255.0	COG0329@1|root,COG0329@2|Bacteria,2I92Q@201174|Actinobacteria	201174|Actinobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CMS3_k127_5996150_11	89187.ISM_09961	1.939e-69	253.0	28NPB@1|root,2ZBP9@2|Bacteria,1R3HY@1224|Proteobacteria	1224|Proteobacteria	S	Sulfotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
CMS3_k127_5996150_33	1035308.AQYY01000001_gene1475	3.861e-09	68.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
CMS3_k127_5996150_23	436229.JOEH01000002_gene3431	1.152e-25	111.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
CMS3_k127_5996150_1	1352941.M877_29430	4.261e-231	730.0	COG2936@1|root,COG2936@2|Bacteria,2GKZH@201174|Actinobacteria	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS3_k127_5996150_3	1131814.JAFO01000001_gene741	2.239e-109	366.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,3EY3I@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	PFAM aldo keto reductase	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
CMS3_k127_5996150_37	1114856.C496_05977	3.525e-06	59.0	COG0697@1|root,arCOG00272@2157|Archaea,2XUHA@28890|Euryarchaeota,23UY1@183963|Halobacteria	183963|Halobacteria	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_5996150_30	113355.CM001775_gene2074	2.701e-10	72.0	COG0715@1|root,COG0715@2|Bacteria,1G0R1@1117|Cyanobacteria	1117|Cyanobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	nrtA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K15576	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
CMS3_k127_5996150_14	397278.JOJN01000002_gene616	4.334e-56	209.0	COG0600@1|root,COG0600@2|Bacteria,2IRG7@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
CMS3_k127_5996150_5	397278.JOJN01000002_gene617	4.457e-98	329.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4DQM4@85009|Propionibacteriales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
CMS3_k127_5996150_2	1120983.KB894571_gene2468	3.013e-116	385.0	COG1073@1|root,COG1073@2|Bacteria,1PJHR@1224|Proteobacteria,2U2QB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5996150_29	101510.RHA1_ro02732	6.958e-13	75.0	COG3631@1|root,COG3631@2|Bacteria	2|Bacteria	S	light absorption	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
CMS3_k127_5996150_4	1229780.BN381_80377	1.925e-108	368.0	COG1894@1|root,COG1894@2|Bacteria,2GNN9@201174|Actinobacteria,3UXSE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	nuoF_1	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,NADH_4Fe-4S
CMS3_k127_5996150_15	1229780.BN381_290011	5.519e-54	199.0	COG2375@1|root,COG2375@2|Bacteria,2HEWI@201174|Actinobacteria,3UWVN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Siderophore-interacting FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_9,SIP
CMS3_k127_5996150_34	1196031.ALEG01000067_gene4769	6.091e-08	59.0	2DRDY@1|root,33BC0@2|Bacteria,1VFFN@1239|Firmicutes,4HP9H@91061|Bacilli,1ZJ53@1386|Bacillus	91061|Bacilli	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
CMS3_k127_5996150_28	243274.THEMA_07715	2.045e-15	86.0	COG0842@1|root,COG0842@2|Bacteria,2GBXF@200918|Thermotogae	200918|Thermotogae	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CMS3_k127_5996150_19	272557.APE_2516	3.044e-39	160.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPS7@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_5996150_27	397945.Aave_0961	2.427e-16	93.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VQRU@28216|Betaproteobacteria,4AIYG@80864|Comamonadaceae	28216|Betaproteobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS3_k127_5996150_26	1150626.PHAMO_210085	1.23e-16	91.0	COG1493@1|root,COG1493@2|Bacteria,1RE0J@1224|Proteobacteria,2UFMX@28211|Alphaproteobacteria,2JZUA@204441|Rhodospirillales	204441|Rhodospirillales	T	HPr Serine kinase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5996150_35	1120936.KB907220_gene2021	7.713e-08	60.0	COG0465@1|root,COG0465@2|Bacteria,2H5KC@201174|Actinobacteria,4EFWZ@85012|Streptosporangiales	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CMS3_k127_5996150_24	1218108.KB908302_gene2782	3.42e-22	113.0	COG1520@1|root,COG5635@1|root,COG1520@2|Bacteria,COG5635@2|Bacteria,4NHWU@976|Bacteroidetes	976|Bacteroidetes	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA,DUF4365,NACHT
CMS3_k127_5996150_13	1144275.COCOR_07898	1.175e-66	253.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2YU5Y@29|Myxococcales	28221|Deltaproteobacteria	M	Penicillin-binding Protein dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	MecA_N,PBP_dimer,Transpeptidase
CMS3_k127_6015341_3	1122603.ATVI01000005_gene2971	5.402e-83	289.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1X4K6@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia	gatAX	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase,Lipocalin_5
CMS3_k127_6015341_13	1042876.PPS_3259	4.872e-12	75.0	COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,1S7F3@1236|Gammaproteobacteria,1YXPC@136845|Pseudomonas putida group	1236|Gammaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS3_k127_6015341_0	1121374.KB891575_gene1538	4.898e-202	639.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
CMS3_k127_6015341_5	469371.Tbis_2610	3.628e-54	199.0	COG0804@1|root,COG0804@2|Bacteria,2GM7X@201174|Actinobacteria,4E07M@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
CMS3_k127_6015341_9	28444.JODQ01000012_gene3333	5.166e-24	109.0	COG1309@1|root,COG1309@2|Bacteria,2IC0Q@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_6015341_4	204669.Acid345_1819	2.412e-79	279.0	COG0078@1|root,COG0078@2|Bacteria,3Y4R3@57723|Acidobacteria,2JP1M@204432|Acidobacteriia	204432|Acidobacteriia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS3_k127_6015341_10	1123367.C666_15095	2.078e-23	111.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase,Glyoxalase_4
CMS3_k127_6015341_1	298653.Franean1_6600	5.963e-143	508.0	COG2319@1|root,COG3629@1|root,COG2319@2|Bacteria,COG3629@2|Bacteria,2GJN3@201174|Actinobacteria,4ES8H@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,PD40,Trans_reg_C,WD40
CMS3_k127_6015341_2	483218.BACPEC_00796	5.737e-137	448.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,267NA@186813|unclassified Clostridiales	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
CMS3_k127_6015341_7	158190.SpiGrapes_2343	2.129e-28	119.0	COG1764@1|root,COG1764@2|Bacteria	2|Bacteria	O	response to oxidative stress	ymaD	-	-	-	-	-	-	-	-	-	-	-	OsmC
CMS3_k127_6015341_8	1313172.YM304_40350	2.152e-25	110.0	COG0607@1|root,COG0607@2|Bacteria,2GR81@201174|Actinobacteria	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CMS3_k127_6015341_12	1382356.JQMP01000001_gene879	1.683e-15	81.0	COG0607@1|root,COG0607@2|Bacteria,2G71Z@200795|Chloroflexi,27YN5@189775|Thermomicrobia	189775|Thermomicrobia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CMS3_k127_6015341_14	1123368.AUIS01000003_gene1732	2.552e-11	71.0	COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,1S8ZI@1236|Gammaproteobacteria,2NCVA@225057|Acidithiobacillales	225057|Acidithiobacillales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CMS3_k127_6015341_11	235985.BBPN01000020_gene6503	1.766e-19	91.0	COG1937@1|root,COG1937@2|Bacteria,2IQ7U@201174|Actinobacteria,2NJCG@228398|Streptacidiphilus	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Trns_repr_metal
CMS3_k127_6015341_6	35754.JNYJ01000047_gene3527	7.8e-33	133.0	COG1404@1|root,COG1404@2|Bacteria,2IAS7@201174|Actinobacteria,4DHP7@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
CMS3_k127_6031205_6	1151061.CAJY01000040_gene4143	4.864e-23	98.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS3_k127_6031205_4	931627.MycrhDRAFT_6817	3.204e-49	203.0	COG1752@1|root,COG1752@2|Bacteria,2IAR4@201174|Actinobacteria	201174|Actinobacteria	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6031205_2	291985.CCSI01000001_gene2150	3.312e-87	305.0	COG1835@1|root,COG1835@2|Bacteria,1PVUR@1224|Proteobacteria,2TTRB@28211|Alphaproteobacteria,2K98C@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
CMS3_k127_6031205_1	243231.GSU1538	3.337e-154	499.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N38@68525|delta/epsilon subdivisions,2WK56@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,Cytochrom_C
CMS3_k127_6031205_3	1122182.KB903836_gene5080	6.685e-76	264.0	COG3173@1|root,COG3173@2|Bacteria,2GKUU@201174|Actinobacteria,4DD6T@85008|Micromonosporales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS3_k127_6031205_5	596151.DesfrDRAFT_0282	2.102e-42	174.0	2AD1R@1|root,312PX@2|Bacteria,1QCNM@1224|Proteobacteria,433DK@68525|delta/epsilon subdivisions,2WY1V@28221|Deltaproteobacteria,2M8UB@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
CMS3_k127_6031205_7	1123508.JH636443_gene4900	1.331e-06	59.0	COG0500@1|root,COG2226@2|Bacteria,2J02U@203682|Planctomycetes	203682|Planctomycetes	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
CMS3_k127_6031205_0	1229780.BN381_50096	2.283e-205	655.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,3UWEG@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
CMS3_k127_603941_0	1313172.YM304_29400	8.047e-173	563.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CMRZ@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
CMS3_k127_603941_5	1313172.YM304_37230	0.0003226	51.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,RDD
CMS3_k127_603941_2	751944.HALDL1_13135	5.333e-40	169.0	COG2203@1|root,arCOG02360@1|root,arCOG02360@2157|Archaea,arCOG02369@2157|Archaea,2XW05@28890|Euryarchaeota	28890|Euryarchaeota	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_4
CMS3_k127_603941_4	1122182.KB903835_gene4670	3.567e-07	59.0	COG1714@1|root,COG1714@2|Bacteria,2GN0D@201174|Actinobacteria,4DCSS@85008|Micromonosporales	201174|Actinobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,RDD
CMS3_k127_603941_3	596151.DesfrDRAFT_1475	8.535e-13	73.0	COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,42RTD@68525|delta/epsilon subdivisions,2WNC2@28221|Deltaproteobacteria,2MBI7@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Amino acid-binding ACT	-	-	-	-	-	-	-	-	-	-	-	-	ACT
CMS3_k127_603941_1	1227497.C491_10969	1.287e-41	159.0	COG2141@1|root,arCOG02410@2157|Archaea,2XT6F@28890|Euryarchaeota,23TX5@183963|Halobacteria	183963|Halobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_6044223_11	469383.Cwoe_5927	2.829e-32	128.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4CQ40@84995|Rubrobacteria	84995|Rubrobacteria	C	Cytochrome b	-	-	-	ko:K03887	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_B
CMS3_k127_6044223_12	237368.SCABRO_01591	7.679e-27	128.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,2IX9E@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome b subunit of the bc complex	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2,Cytochrom_C,Cytochrome_B
CMS3_k127_6044223_15	1384056.N787_10295	8.426e-13	82.0	COG0607@1|root,COG2010@1|root,COG0607@2|Bacteria,COG2010@2|Bacteria,1R6Z0@1224|Proteobacteria,1RXZ9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,Rhodanese
CMS3_k127_6044223_9	797209.ZOD2009_18889	6.04e-47	177.0	COG1296@1|root,arCOG04452@2157|Archaea,2XWP8@28890|Euryarchaeota,23VF2@183963|Halobacteria	183963|Halobacteria	E	branched-chain amino acid permease (azaleucine resistance)	azlC	-	-	-	-	-	-	-	-	-	-	-	AzlC
CMS3_k127_6044223_13	1395571.TMS3_0106300	1.731e-21	102.0	COG4392@1|root,COG4392@2|Bacteria,1NH6U@1224|Proteobacteria,1SGUY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	branched-chain amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
CMS3_k127_6044223_10	693977.Deipr_1853	3.374e-37	146.0	COG4843@1|root,COG4843@2|Bacteria,1WKI2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179
CMS3_k127_6044223_8	314345.SPV1_05168	1.777e-66	239.0	COG0590@1|root,COG0590@2|Bacteria,1RE8P@1224|Proteobacteria	1224|Proteobacteria	FJ	deaminase	cdd	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
CMS3_k127_6044223_5	1121013.P873_09275	2.691e-73	257.0	COG0330@1|root,COG0330@2|Bacteria,1P8ZI@1224|Proteobacteria,1RUQU@1236|Gammaproteobacteria,1X4NG@135614|Xanthomonadales	135614|Xanthomonadales	O	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS3_k127_6044223_16	1122223.KB890700_gene1913	9.504e-10	64.0	COG4877@1|root,COG4877@2|Bacteria,1WKMS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_5
CMS3_k127_6044223_6	994479.GL877878_gene768	5.452e-72	252.0	COG0685@1|root,COG0685@2|Bacteria,2I92A@201174|Actinobacteria,4E35Z@85010|Pseudonocardiales	201174|Actinobacteria	E	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
CMS3_k127_6044223_1	247633.GP2143_05680	1.456e-218	694.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,1S1SA@1236|Gammaproteobacteria,1J8ND@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
CMS3_k127_6044223_0	1380394.JADL01000010_gene4323	2.484e-245	776.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2TUJB@28211|Alphaproteobacteria,2JQGJ@204441|Rhodospirillales	204441|Rhodospirillales	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
CMS3_k127_6044223_3	1469245.JFBG01000006_gene1587	2.619e-139	448.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RZF4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	COG1410 Methionine synthase I cobalamin-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Pterin_bind
CMS3_k127_6044223_14	748247.AZKH_p0167	1.53e-20	102.0	2CDZD@1|root,32RYT@2|Bacteria,1N0AT@1224|Proteobacteria	1224|Proteobacteria	S	Virulence factor	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_fact
CMS3_k127_6044223_7	570967.JMLV01000010_gene1278	3.294e-67	235.0	28I8Y@1|root,2Z8BR@2|Bacteria,1MXN1@1224|Proteobacteria,2TRAQ@28211|Alphaproteobacteria,2JS8U@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
CMS3_k127_6044223_4	1469245.JFBG01000006_gene1588	3.703e-114	373.0	COG5012@1|root,COG5012@2|Bacteria,1QDZ3@1224|Proteobacteria,1RYST@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
CMS3_k127_6044223_2	1123251.ATWM01000009_gene2831	6.032e-141	455.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria,4FENX@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the GcvT family	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
CMS3_k127_6062392_7	44056.XP_009035066.1	7.792e-68	238.0	COG0626@1|root,KOG0053@2759|Eukaryota	2759|Eukaryota	E	cystathionine gamma-synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cys_Met_Meta_PP
CMS3_k127_6062392_8	1499967.BAYZ01000090_gene4964	3.233e-61	223.0	COG1738@1|root,COG1738@2|Bacteria	2|Bacteria	S	queuosine salvage	M1-344	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
CMS3_k127_6062392_6	604331.AUHY01000008_gene468	8.577e-71	252.0	COG5640@1|root,COG5640@2|Bacteria,1WN2M@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Trypsin-like serine protease	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin
CMS3_k127_6062392_12	1229780.BN381_80176	1.751e-40	162.0	COG0697@1|root,COG0697@2|Bacteria,2GMPU@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_6062392_3	469383.Cwoe_0665	1.777e-128	421.0	COG0520@1|root,COG0520@2|Bacteria,2H9MG@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_6062392_11	65497.JODV01000007_gene635	2.473e-45	178.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4DXB2@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Cell envelope-related transcriptional attenuator	lytR2	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
CMS3_k127_6062392_13	35754.JNYJ01000003_gene6394	4.576e-35	143.0	COG0500@1|root,COG2226@2|Bacteria,2IAGR@201174|Actinobacteria,4DIQB@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_6062392_0	395493.BegalDRAFT_1084	6.285e-265	826.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,4608Q@72273|Thiotrichales	72273|Thiotrichales	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
CMS3_k127_6062392_18	502025.Hoch_0529	1.802e-10	63.0	COG3526@1|root,COG3526@2|Bacteria	2|Bacteria	O	Rdx family	-	-	-	ko:K07401	-	-	-	-	ko00000	-	-	-	Rdx
CMS3_k127_6062392_17	1142394.PSMK_20550	5.644e-11	70.0	2CBRY@1|root,33DAH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6062392_9	685778.AORL01000016_gene2292	5.89e-60	235.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,2K1UV@204457|Sphingomonadales	204457|Sphingomonadales	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS3_k127_6062392_10	40571.JOEA01000041_gene4672	2.336e-46	186.0	COG0815@1|root,COG0815@2|Bacteria,2GJ9F@201174|Actinobacteria,4DXYD@85010|Pseudonocardiales	201174|Actinobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
CMS3_k127_6062392_2	338966.Ppro_0566	3.672e-133	438.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria,43TEH@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_6062392_5	247634.GPB2148_2986	2.484e-79	273.0	COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,1S2FJ@1236|Gammaproteobacteria,1J7UA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS3_k127_6062392_15	443144.GM21_1097	1.46e-18	93.0	COG0746@1|root,COG0746@2|Bacteria,1PJ8E@1224|Proteobacteria,42VYH@68525|delta/epsilon subdivisions,2WRBB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	-	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS3_k127_6062392_16	1452535.JARD01000015_gene633	6.358e-13	79.0	2EGCD@1|root,33A46@2|Bacteria,2HST0@201174|Actinobacteria,4FQBR@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,Septum_form
CMS3_k127_6062392_4	1229780.BN381_130022	1.075e-84	291.0	COG0150@1|root,COG0150@2|Bacteria,2GJNY@201174|Actinobacteria,3UWBB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	AIR synthase related protein, C-terminal domain	purM	GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016882,GO:0044424,GO:0044444,GO:0044464	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
CMS3_k127_6062392_1	272134.KB731324_gene4737	4.95e-145	473.0	COG0034@1|root,COG0034@2|Bacteria,1G1C9@1117|Cyanobacteria,1H8KH@1150|Oscillatoriales	1117|Cyanobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
CMS3_k127_6062392_14	469371.Tbis_0058	1.994e-30	130.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria,4E02H@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Rhomboid family	gluP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,zf-B_box
CMS3_k127_6081001_0	665577.JH993790_gene2750	7.536e-16	87.0	COG3415@1|root,COG3415@2|Bacteria,2HK0D@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,Terminase_5
CMS3_k127_6081001_2	562973.HMPREF0059_00949	0.0004335	47.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria,4D3ZA@85005|Actinomycetales	201174|Actinobacteria	L	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
CMS3_k127_6081001_1	1410668.JNKC01000016_gene993	4.319e-06	50.0	2DES4@1|root,2ZP1M@2|Bacteria,1W3CF@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6082144_3	635013.TherJR_2703	8.989e-73	254.0	COG1131@1|root,COG1131@2|Bacteria,1TPZR@1239|Firmicutes,247NW@186801|Clostridia,2613B@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_6082144_2	635013.TherJR_2703	6.326e-87	303.0	COG1131@1|root,COG1131@2|Bacteria,1TPZR@1239|Firmicutes,247NW@186801|Clostridia,2613B@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_6082144_5	555088.DealDRAFT_0085	2.261e-43	162.0	COG1725@1|root,COG1725@2|Bacteria,1V9ZC@1239|Firmicutes,24NTW@186801|Clostridia,42KP5@68298|Syntrophomonadaceae	186801|Clostridia	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS3_k127_6082144_0	1440053.JOEI01000001_gene1664	0.0	1286.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS3_k127_6082144_8	309801.trd_0152	2.503e-15	78.0	2EQM1@1|root,33I6Z@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
CMS3_k127_6082144_7	1313172.YM304_01150	3.876e-38	156.0	COG1808@1|root,COG1808@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
CMS3_k127_6082144_4	285535.JOEY01000073_gene9814	8.32e-62	224.0	COG0329@1|root,COG0329@2|Bacteria,2I92Q@201174|Actinobacteria	201174|Actinobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CMS3_k127_6082144_6	439235.Dalk_0153	2.798e-38	161.0	COG0786@1|root,COG0786@2|Bacteria,1RKK8@1224|Proteobacteria,43BET@68525|delta/epsilon subdivisions,2X6T9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Sodium/glutamate symporter	-	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
CMS3_k127_6082144_1	1463825.JNXC01000012_gene1808	2.892e-96	331.0	COG0076@1|root,COG0076@2|Bacteria,2GKIH@201174|Actinobacteria,4DZY2@85010|Pseudonocardiales	201174|Actinobacteria	E	glutamate decarboxylase	-	-	4.1.1.11,4.1.1.25,4.1.2.27	ko:K01634,ko:K18933	ko00350,ko00410,ko00600,ko00680,ko00770,ko01100,ko01110,ko04071,map00350,map00410,map00600,map00680,map00770,map01100,map01110,map04071	M00100	R00489,R00736,R02464,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
CMS3_k127_6088906_4	1229203.KI301992_gene2687	2.507e-53	202.0	COG0683@1|root,COG0683@2|Bacteria,2GMCF@201174|Actinobacteria	201174|Actinobacteria	E	ABC-type branched-chain amino acid transport	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
CMS3_k127_6088906_2	585531.HMPREF0063_10397	2.128e-96	334.0	COG4177@1|root,COG4177@2|Bacteria,2GMGD@201174|Actinobacteria,4DNIE@85009|Propionibacteriales	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS3_k127_6088906_3	40571.JOEA01000006_gene4406	2.633e-67	241.0	COG0559@1|root,COG0559@2|Bacteria,2HDZ9@201174|Actinobacteria,4DZD5@85010|Pseudonocardiales	201174|Actinobacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS3_k127_6088906_0	935866.JAER01000010_gene4131	3.614e-249	783.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4DPKK@85009|Propionibacteriales	201174|Actinobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
CMS3_k127_6088906_1	1430440.MGMSRv2_3172	1.58e-185	595.0	COG1012@1|root,COG1012@2|Bacteria,1MY4N@1224|Proteobacteria,2TV5F@28211|Alphaproteobacteria,2JQJC@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
CMS3_k127_6096762_2	1265505.ATUG01000002_gene2331	7.687e-67	235.0	COG1028@1|root,COG3427@1|root,COG1028@2|Bacteria,COG3427@2|Bacteria,1P9R4@1224|Proteobacteria,42TE9@68525|delta/epsilon subdivisions,2WPGF@28221|Deltaproteobacteria,2MIUD@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2,adh_short
CMS3_k127_6096762_8	1380346.JNIH01000010_gene3018	2.923e-19	92.0	COG0640@1|root,COG0640@2|Bacteria,2IKWF@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
CMS3_k127_6096762_5	1160137.KB907308_gene7286	7.768e-26	112.0	COG3832@1|root,COG3832@2|Bacteria,2ISCU@201174|Actinobacteria,4G1QF@85025|Nocardiaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
CMS3_k127_6096762_1	1380386.JIAW01000004_gene88	2.737e-87	294.0	COG0684@1|root,COG0684@2|Bacteria,2IH5H@201174|Actinobacteria,237HZ@1762|Mycobacteriaceae	201174|Actinobacteria	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
CMS3_k127_6096762_10	35754.JNYJ01000055_gene9949	7.206e-13	70.0	COG1595@1|root,COG1595@2|Bacteria,2IMAP@201174|Actinobacteria,4DJR1@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r4_2
CMS3_k127_6096762_0	296591.Bpro_4279	7.707e-105	370.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
CMS3_k127_6096762_3	935863.AWZR01000007_gene259	4.292e-66	237.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1X3XJ@135614|Xanthomonadales	1236|Gammaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm2	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CMS3_k127_6096762_9	1121877.JQKF01000003_gene1511	3.908e-19	100.0	2CD9C@1|root,2ZWAS@2|Bacteria,2GYGD@201174|Actinobacteria,4CNXP@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6096762_7	314285.KT71_01645	1.185e-19	103.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1J8TX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
CMS3_k127_6096762_4	1416759.AYMR01000005_gene3720	1.639e-51	195.0	COG1305@1|root,COG1305@2|Bacteria,2GN5D@201174|Actinobacteria,4FMS0@85023|Microbacteriaceae	201174|Actinobacteria	E	Bacterial transglutaminase-like N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
CMS3_k127_6096762_6	644283.Micau_1840	1.582e-20	102.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4DGFS@85008|Micromonosporales	201174|Actinobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS3_k127_6120175_0	1230476.C207_02861	1.768e-72	260.0	COG2114@1|root,COG2114@2|Bacteria,1QWNC@1224|Proteobacteria,2TRQB@28211|Alphaproteobacteria,3JQN6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,Guanylate_cyc,HAMP
CMS3_k127_6120175_1	909613.UO65_4177	3.602e-44	169.0	COG0545@1|root,COG0545@2|Bacteria,2IHQC@201174|Actinobacteria,4E3SA@85010|Pseudonocardiales	201174|Actinobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	fkbP	-	5.2.1.8	ko:K01802,ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
CMS3_k127_615147_1	1121033.AUCF01000032_gene2622	8.999e-21	92.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria,2JPDU@204441|Rhodospirillales	204441|Rhodospirillales	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
CMS3_k127_615147_0	502025.Hoch_3028	1.911e-87	304.0	COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,43CF5@68525|delta/epsilon subdivisions,2WMDP@28221|Deltaproteobacteria,2Z2D8@29|Myxococcales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
CMS3_k127_6181453_2	1179773.BN6_08330	1.529e-53	212.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4DXIX@85010|Pseudonocardiales	201174|Actinobacteria	E	ABC transporter	fbpC	-	3.6.3.30	ko:K02010,ko:K02052,ko:K02062	ko02010,ko02024,map02010,map02024	M00190,M00191,M00193	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11,3.A.1.19	-	-	ABC_tran,TOBE_2
CMS3_k127_6181453_0	1944.JOAZ01000027_gene1592	1.94e-157	514.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria,4188P@629295|Streptomyces griseus group	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	thiP	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1
CMS3_k127_6181453_1	765420.OSCT_0522	3.778e-106	354.0	COG4143@1|root,COG4143@2|Bacteria,2G615@200795|Chloroflexi,376Q5@32061|Chloroflexia	32061|Chloroflexia	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
CMS3_k127_6181453_3	1121472.AQWN01000001_gene43	2.26e-22	107.0	COG1564@1|root,COG1564@2|Bacteria,1VA0W@1239|Firmicutes,24NG6@186801|Clostridia,261Z3@186807|Peptococcaceae	186801|Clostridia	H	PFAM Thiamin pyrophosphokinase, vitamin B1 binding domain	thiN	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
CMS3_k127_6198850_0	1214242.B446_22340	2.031e-220	696.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria	201174|Actinobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL2	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009295,GO:0009408,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016465,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042026,GO:0042262,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043388,GO:0043590,GO:0044093,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051716,GO:0061077,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090143,GO:0090304,GO:0097159,GO:0101031,GO:1901360,GO:1901363,GO:1990220,GO:2000677,GO:2000679	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS3_k127_6198850_5	1288079.AUKN01000012_gene766	3.779e-37	141.0	COG0234@1|root,COG0234@2|Bacteria,2IKTH@201174|Actinobacteria	201174|Actinobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
CMS3_k127_6198850_2	326427.Cagg_2155	5.23e-90	312.0	COG2133@1|root,COG2133@2|Bacteria,2G62S@200795|Chloroflexi,375V8@32061|Chloroflexia	32061|Chloroflexia	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
CMS3_k127_6198850_3	219305.MCAG_01435	5.192e-51	199.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4DCDB@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
CMS3_k127_6198850_1	1229780.BN381_130036	2.387e-98	331.0	COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria,3UWA4@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
CMS3_k127_6198850_6	401526.TcarDRAFT_0379	1.395e-33	136.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,4H4WN@909932|Negativicutes	909932|Negativicutes	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
CMS3_k127_6198850_4	1313172.YM304_08940	2.357e-39	154.0	COG1214@1|root,COG1214@2|Bacteria	2|Bacteria	O	tRNA threonylcarbamoyladenosine modification	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CMS3_k127_6213686_0	984262.SGRA_1904	0.0	1427.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,1INXI@117747|Sphingobacteriia	976|Bacteroidetes	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
CMS3_k127_6213686_1	35754.JNYJ01000060_gene2493	4.717e-109	363.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4D8KQ@85008|Micromonosporales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
CMS3_k127_6291902_6	1118054.CAGW01000080_gene2751	0.0003227	52.0	2DFAH@1|root,2ZR3V@2|Bacteria,1W1ZU@1239|Firmicutes,4I1J2@91061|Bacilli,2743W@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6291902_2	1313172.YM304_04910	1.376e-28	120.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6291902_0	1038859.AXAU01000015_gene939	3.253e-39	149.0	2DBSD@1|root,2ZARI@2|Bacteria,1MX0F@1224|Proteobacteria,2TUNC@28211|Alphaproteobacteria,3JQX7@41294|Bradyrhizobiaceae	1224|Proteobacteria	S	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6291902_1	1313172.YM304_12600	4.507e-38	152.0	2DBSD@1|root,2ZARI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6291902_3	595460.RRSWK_02125	2.237e-11	69.0	COG1357@1|root,COG1511@1|root,COG2931@1|root,COG3291@1|root,COG1357@2|Bacteria,COG1511@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,2IZ0P@203682|Planctomycetes	203682|Planctomycetes	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Laminin_G_3
CMS3_k127_6291902_4	1120936.KB907216_gene3838	2.293e-07	65.0	COG3147@1|root,COG3147@2|Bacteria,2ID4R@201174|Actinobacteria,4EHHH@85012|Streptosporangiales	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6291902_5	585531.HMPREF0063_10478	3.58e-06	57.0	COG1404@1|root,COG4932@1|root,COG1404@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Peptidase_S8,SLH
CMS3_k127_6311236_1	653045.Strvi_4853	2.823e-85	289.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
CMS3_k127_6311236_0	644283.Micau_5092	1.557e-129	432.0	COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria,4DGZ6@85008|Micromonosporales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_6311236_2	1122611.KB903939_gene559	8.843e-82	280.0	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria	201174|Actinobacteria	E	Acetylornithine deacetylase	-	-	3.5.1.18	ko:K01439,ko:K05831	ko00220,ko00300,ko01100,ko01120,ko01210,ko01230,map00220,map00300,map01100,map01120,map01210,map01230	M00016,M00031,M00763	R02734,R09779,R10933	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS3_k127_6321685_1	1120950.KB892776_gene793	3.44e-82	286.0	COG2021@1|root,COG2021@2|Bacteria,2GIZI@201174|Actinobacteria,4DVIS@85009|Propionibacteriales	201174|Actinobacteria	E	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_6321685_6	68170.KL590535_gene3759	2.427e-14	82.0	COG5401@1|root,COG5401@2|Bacteria,2H4HT@201174|Actinobacteria	201174|Actinobacteria	S	Immunoglobulin-like domain of bacterial spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
CMS3_k127_6321685_9	358823.DF19_18065	0.0006281	49.0	COG3832@1|root,COG3832@2|Bacteria,2IHQS@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
CMS3_k127_6321685_0	642492.Clole_1307	8.662e-158	513.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS3_k127_6321685_4	1120980.JQKH01000081_gene857	8.029e-43	173.0	2BZ6D@1|root,2ZC6J@2|Bacteria,1RBC8@1224|Proteobacteria,2W4E7@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6321685_3	1226325.HMPREF1548_06752	1.386e-66	246.0	COG0814@1|root,COG0814@2|Bacteria,1UTY5@1239|Firmicutes,24BAJ@186801|Clostridia,36SUU@31979|Clostridiaceae	186801|Clostridia	E	Tryptophan/tyrosine permease family	-	-	-	-	-	-	-	-	-	-	-	-	Trp_Tyr_perm
CMS3_k127_6321685_8	1125971.ASJB01000062_gene4503	7.665e-11	71.0	COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria,4E4EZ@85010|Pseudonocardiales	201174|Actinobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	LZ_Tnp_IS481,rve,rve_3
CMS3_k127_6321685_2	858619.CVAR_1819	2.997e-74	259.0	COG1119@1|root,COG1119@2|Bacteria,2GIXX@201174|Actinobacteria,22JVJ@1653|Corynebacteriaceae	201174|Actinobacteria	P	ABC-type molybdenum transport system ATPase component photorepair protein PhrA	ylmA	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS3_k127_6321685_5	1123023.JIAI01000006_gene60	3.256e-24	107.0	COG1802@1|root,COG1802@2|Bacteria,2GKH7@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS3_k127_6341478_7	1184609.KILIM_007_00120	2.17e-47	184.0	COG3662@1|root,COG3662@2|Bacteria,2GJD2@201174|Actinobacteria,4F7Q1@85018|Dermatophilaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
CMS3_k127_6341478_5	288000.BBta_4037	4.205e-55	202.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,3JTG8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	MA20_30275	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
CMS3_k127_6341478_3	1380391.JIAS01000012_gene4124	4.405e-94	323.0	COG2114@1|root,COG2114@2|Bacteria,1ND4Q@1224|Proteobacteria,2U51W@28211|Alphaproteobacteria,2JXWG@204441|Rhodospirillales	204441|Rhodospirillales	T	Protein of unknown function (DUF2652)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2652
CMS3_k127_6341478_11	35754.JNYJ01000022_gene8187	5.068e-32	133.0	COG1846@1|root,COG1846@2|Bacteria,2GJ6W@201174|Actinobacteria,4DEDI@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
CMS3_k127_6341478_6	443218.AS9A_2374	3.918e-54	199.0	COG4923@1|root,COG4923@2|Bacteria,2IJP8@201174|Actinobacteria,238UV@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF429)	-	-	-	-	-	-	-	-	-	-	-	-	DUF429
CMS3_k127_6341478_14	1121019.AUMN01000024_gene3616	2.14e-15	82.0	COG0735@1|root,COG0735@2|Bacteria,2IFBR@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the Fur family	catR	-	-	ko:K22297	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS3_k127_6341478_8	1288083.AUKR01000009_gene1850	1.476e-40	158.0	COG3576@1|root,COG3576@2|Bacteria,2IG3P@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_6341478_9	1123023.JIAI01000007_gene1796	2.539e-37	157.0	COG1721@1|root,COG1721@2|Bacteria,2I9E2@201174|Actinobacteria,4DY7U@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_6341478_2	479433.Caci_3076	4.128e-113	378.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria	201174|Actinobacteria	S	associated with various cellular activities	moxR3	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_6341478_15	1713.JOFV01000007_gene2897	2.615e-13	80.0	2DPEM@1|root,331S3@2|Bacteria,2HXXS@201174|Actinobacteria,4F1KD@85016|Cellulomonadaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
CMS3_k127_6341478_4	485913.Krac_10783	7.142e-64	226.0	COG3382@1|root,COG3382@2|Bacteria,2G96A@200795|Chloroflexi	200795|Chloroflexi	S	B3/4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
CMS3_k127_6341478_13	311424.DhcVS_41	2.139e-17	91.0	COG0500@1|root,COG2226@2|Bacteria,2GBVK@200795|Chloroflexi,34D1G@301297|Dehalococcoidia	301297|Dehalococcoidia	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_6341478_0	1385519.N801_07210	5.982e-152	508.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria,4FFGY@85021|Intrasporangiaceae	201174|Actinobacteria	CP	Subunit A of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali	mrpA/mrpB	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
CMS3_k127_6341478_12	33876.JNXY01000049_gene2332	5.365e-22	108.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria,4D9ZF@85008|Micromonosporales	201174|Actinobacteria	CP	Na H antiporter	mrpA/mrpB	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
CMS3_k127_6341478_10	471853.Bcav_3817	6.67e-34	133.0	COG1006@1|root,COG1006@2|Bacteria,2ISBC@201174|Actinobacteria	201174|Actinobacteria	P	Multisubunit Na H antiporter MnhC subunit	mrpC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
CMS3_k127_6341478_1	1229780.BN381_150134	1.183e-135	449.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria,3UX2B@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	CP	Proton-conducting membrane transporter	mrpD	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
CMS3_k127_6344752_2	350058.Mvan_1052	1.095e-107	362.0	COG0438@1|root,COG0438@2|Bacteria,2GNPG@201174|Actinobacteria,232RQ@1762|Mycobacteriaceae	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_6344752_4	326424.FRAAL1701	9.03e-91	313.0	COG1331@1|root,COG1331@2|Bacteria,2I5YD@201174|Actinobacteria,4EU7H@85013|Frankiales	201174|Actinobacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6344752_0	68170.KL590544_gene764	3.084e-155	505.0	COG2152@1|root,COG2152@2|Bacteria,2HNS8@201174|Actinobacteria,4EA2Q@85010|Pseudonocardiales	201174|Actinobacteria	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
CMS3_k127_6344752_3	643648.Slip_0761	8.482e-105	357.0	COG3934@1|root,COG3934@2|Bacteria,1UEWM@1239|Firmicutes,24AQC@186801|Clostridia,42KI0@68298|Syntrophomonadaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Cellulase,Glyco_hydro_42M
CMS3_k127_6344752_1	518766.Rmar_2613	3.045e-146	473.0	COG0438@1|root,COG0438@2|Bacteria,4NIWP@976|Bacteroidetes	976|Bacteroidetes	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_6344752_5	43354.JOIJ01000001_gene396	1.46e-22	112.0	COG3147@1|root,COG3147@2|Bacteria,2GYC2@201174|Actinobacteria,4ECZ4@85010|Pseudonocardiales	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6453748_4	886293.Sinac_1926	2.089e-14	76.0	COG1011@1|root,COG1011@2|Bacteria,2J05I@203682|Planctomycetes	203682|Planctomycetes	GK	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CMS3_k127_6453748_2	82654.Pse7367_3168	3.383e-26	126.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2202@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G13T@1117|Cyanobacteria,1H77Q@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_8,PAS_9,Response_reg
CMS3_k127_6453748_0	756272.Plabr_0410	1.739e-72	252.0	COG5587@1|root,COG5587@2|Bacteria,2J2RK@203682|Planctomycetes	203682|Planctomycetes	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
CMS3_k127_6453748_3	1206739.BAGJ01000272_gene5324	5.314e-15	79.0	COG0346@1|root,COG0346@2|Bacteria,2IM7G@201174|Actinobacteria,4G93D@85025|Nocardiaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_6453748_1	1108045.GORHZ_205_00160	2.14e-28	120.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
CMS3_k127_649502_7	1521187.JPIM01000028_gene1594	1.545e-82	280.0	COG0745@1|root,COG0745@2|Bacteria,2G6JT@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_649502_20	1492737.FEM08_02620	2.57e-06	60.0	COG5662@1|root,COG5662@2|Bacteria,4PP3I@976|Bacteroidetes,1IKMR@117743|Flavobacteriia,2P0SG@237|Flavobacterium	976|Bacteroidetes	K	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
CMS3_k127_649502_4	926550.CLDAP_36880	2.987e-111	368.0	COG0167@1|root,COG0167@2|Bacteria,2G5T6@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
CMS3_k127_649502_0	1304874.JAFY01000002_gene756	0.0	1478.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,3T9V0@508458|Synergistetes	508458|Synergistetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
CMS3_k127_649502_9	1541959.KQ51_00619	9.661e-74	274.0	COG1033@1|root,COG1033@2|Bacteria	2|Bacteria	S	growth of symbiont in host cell	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS3_k127_649502_5	1449353.JQMQ01000004_gene6153	1e-100	335.0	COG1024@1|root,COG1024@2|Bacteria,2GJ1A@201174|Actinobacteria,2NMNN@228398|Streptacidiphilus	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_649502_13	1169161.KB897721_gene4177	6.52e-33	136.0	COG3797@1|root,COG3797@2|Bacteria,2GPDB@201174|Actinobacteria	201174|Actinobacteria	I	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
CMS3_k127_649502_14	1313172.YM304_29220	6.703e-27	112.0	COG1393@1|root,COG1393@2|Bacteria	2|Bacteria	P	arsenate reductase (glutaredoxin) activity	arsC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
CMS3_k127_649502_3	926550.CLDAP_37920	1.289e-156	509.0	COG5598@1|root,COG5598@2|Bacteria	2|Bacteria	H	trimethylamine methyltransferase	mttB2	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
CMS3_k127_649502_8	118173.KB235914_gene3782	1.471e-80	283.0	COG4292@1|root,COG4292@2|Bacteria,1G40Y@1117|Cyanobacteria,1HA5V@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Bacterial low temperature requirement A protein (LtrA)	-	-	-	-	-	-	-	-	-	-	-	-	LtrA
CMS3_k127_649502_11	215803.DB30_6179	1.877e-49	186.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,42PTI@68525|delta/epsilon subdivisions,2WIWT@28221|Deltaproteobacteria,2YURS@29|Myxococcales	28221|Deltaproteobacteria	T	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CMS3_k127_649502_12	640081.Dsui_0053	3.327e-44	170.0	COG1600@1|root,COG1600@2|Bacteria,1R9XX@1224|Proteobacteria,2VQKW@28216|Betaproteobacteria,2KW60@206389|Rhodocyclales	206389|Rhodocyclales	C	COG1145 Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_649502_18	111780.Sta7437_4194	3.139e-16	84.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1FZVR@1117|Cyanobacteria,3VIH3@52604|Pleurocapsales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
CMS3_k127_649502_21	42256.RradSPS_1549	0.0002712	52.0	29DTG@1|root,300RC@2|Bacteria,2HCYB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_649502_15	1125863.JAFN01000001_gene2943	1.979e-21	99.0	COG0824@1|root,COG0824@2|Bacteria,1PEU7@1224|Proteobacteria,42X83@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2
CMS3_k127_649502_2	2002.JOEQ01000024_gene206	1.35e-172	560.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EG83@85012|Streptosporangiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
CMS3_k127_649502_1	471852.Tcur_2882	4.252e-191	614.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EGNQ@85012|Streptosporangiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K02021,ko:K06147,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_membrane,ABC_tran
CMS3_k127_649502_6	384765.SIAM614_12418	2.423e-89	305.0	COG0646@1|root,COG0646@2|Bacteria,1NPFY@1224|Proteobacteria,2UJRS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain	yitJ	-	2.1.1.13,2.1.1.5	ko:K00544,ko:K00548	ko00260,ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00260,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R02821,R09365	RC00035,RC00113,RC00496,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
CMS3_k127_649502_17	520999.PROVALCAL_00099	6.304e-17	86.0	COG3153@1|root,COG3153@2|Bacteria,1MYY0@1224|Proteobacteria,1S7S3@1236|Gammaproteobacteria,3Z8GN@586|Providencia	1236|Gammaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
CMS3_k127_649502_19	1336243.JAEA01000003_gene2227	5.779e-07	57.0	2BW2J@1|root,331CU@2|Bacteria,1N7GK@1224|Proteobacteria,2U7KS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_649502_10	1123024.AUII01000008_gene1849	6.091e-61	220.0	COG1396@1|root,COG1396@2|Bacteria,2GK1R@201174|Actinobacteria,4DXKX@85010|Pseudonocardiales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
CMS3_k127_649502_16	1121921.KB898706_gene3381	9.639e-20	101.0	COG3291@1|root,COG3325@1|root,COG3979@1|root,COG3291@2|Bacteria,COG3325@2|Bacteria,COG3979@2|Bacteria,1MWAR@1224|Proteobacteria,1RPNS@1236|Gammaproteobacteria,2PMUU@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	G	Glyco_18	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_5_12,Glyco_hydro_18,PKD,fn3
CMS3_k127_6497663_4	525904.Tter_1692	1.901e-33	135.0	COG2178@1|root,COG2178@2|Bacteria,2NR1U@2323|unclassified Bacteria	2|Bacteria	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	-
CMS3_k127_6497663_3	429009.Adeg_0922	1.529e-35	147.0	COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,24HG2@186801|Clostridia,42G8D@68295|Thermoanaerobacterales	186801|Clostridia	H	TIGRFAM molybdenum cofactor synthesis domain	mog	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
CMS3_k127_6497663_2	1122612.AUBA01000005_gene2908	1.029e-44	169.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria,2K4GG@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
CMS3_k127_6497663_0	710111.FraQA3DRAFT_5329	1.757e-80	289.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4ERWC@85013|Frankiales	201174|Actinobacteria	H	MoeA domain protein domain I and II	moeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1,2.7.7.9	ko:K00963,ko:K03750	ko00040,ko00052,ko00500,ko00520,ko00790,ko01100,ko01130,map00040,map00052,map00500,map00520,map00790,map01100,map01130	M00129,M00361,M00362,M00549	R00289,R09735	RC00002,RC03462	ko00000,ko00001,ko00002,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
CMS3_k127_6497663_5	887898.HMPREF0551_1531	1.292e-32	134.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,1K08V@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
CMS3_k127_6497663_1	643648.Slip_0897	1.225e-70	244.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,42JJA@68298|Syntrophomonadaceae	186801|Clostridia	F	Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
CMS3_k127_653953_2	1280953.HOC_14048	1.42e-80	277.0	COG1024@1|root,COG1024@2|Bacteria,1NQM5@1224|Proteobacteria,2TSP1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS3_k127_653953_4	1121877.JQKF01000003_gene1502	3.936e-72	250.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria,4CN01@84992|Acidimicrobiia	84992|Acidimicrobiia	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
CMS3_k127_653953_3	979556.MTES_0779	7.899e-74	264.0	COG0702@1|root,COG0702@2|Bacteria,2IQ0Z@201174|Actinobacteria,4FM9R@85023|Microbacteriaceae	201174|Actinobacteria	GM	NmrA-like family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Methyltransf_21,NAD_binding_10
CMS3_k127_653953_8	436229.JOEH01000016_gene7109	1.042e-29	120.0	COG0640@1|root,COG0640@2|Bacteria,2IM1K@201174|Actinobacteria	201174|Actinobacteria	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
CMS3_k127_653953_6	1382306.JNIM01000001_gene2482	1.759e-44	171.0	COG3662@1|root,COG3662@2|Bacteria,2G8VS@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
CMS3_k127_653953_5	446462.Amir_3104	1.034e-58	219.0	COG4552@1|root,COG4552@2|Bacteria,2I8IN@201174|Actinobacteria,4E54H@85010|Pseudonocardiales	201174|Actinobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
CMS3_k127_653953_0	675635.Psed_3988	2.846e-204	647.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DXDJ@85010|Pseudonocardiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_653953_9	247633.GP2143_04440	7.877e-10	64.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,1RMGK@1236|Gammaproteobacteria,1J7VM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_653953_7	479435.Kfla_6176	5.738e-31	123.0	COG1350@1|root,COG1350@2|Bacteria,2GP7D@201174|Actinobacteria,4DPK3@85009|Propionibacteriales	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_653953_1	1313172.YM304_05120	3.221e-174	551.0	COG1350@1|root,COG1350@2|Bacteria,2GP7D@201174|Actinobacteria	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_653953_10	644283.Micau_2031	1.079e-09	63.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DAIN@85008|Micromonosporales	201174|Actinobacteria	S	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Malectin,PKD
CMS3_k127_6539812_1	1125863.JAFN01000001_gene401	1.013e-89	314.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,42P72@68525|delta/epsilon subdivisions,2WKRS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	-	1.1.1.26	ko:K00015,ko:K15893	ko00260,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map01100,map01110,map01120,map01130,map01200	M00532	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS3_k127_6539812_0	1179773.BN6_30480	2.611e-215	678.0	COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria,4DYSV@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_6539812_2	67315.JOBD01000002_gene2662	1.041e-24	117.0	COG0791@1|root,COG1404@1|root,COG0791@2|Bacteria,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,NLPC_P60,PG_binding_1,Trypsin,VCBS
CMS3_k127_6548252_6	765912.Thimo_0834	1.491e-06	59.0	COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1RQ6G@1236|Gammaproteobacteria,1WX95@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
CMS3_k127_6548252_0	360910.BAV2162	3.288e-153	509.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2VHR6@28216|Betaproteobacteria,3T23Q@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the formation of L-threonine from O-phospho-L-homoserine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
CMS3_k127_6548252_1	1449355.JQNR01000005_gene5023	7.153e-92	310.0	COG1387@1|root,COG1387@2|Bacteria,2IR14@201174|Actinobacteria	201174|Actinobacteria	E	Histidinol phosphate phosphatase, HisJ	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
CMS3_k127_6548252_3	1296416.JACB01000003_gene628	2.491e-47	176.0	COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,1HWM1@117743|Flavobacteriia,2YH2K@290174|Aquimarina	976|Bacteroidetes	M	Membrane bound O-acyl transferase family	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
CMS3_k127_6548252_5	1382306.JNIM01000001_gene2489	1.72e-20	99.0	2C5C8@1|root,345UA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6548252_2	390874.Tpet_0541	2.373e-50	187.0	COG0730@1|root,COG0730@2|Bacteria,2GCSH@200918|Thermotogae	200918|Thermotogae	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS3_k127_6548252_4	865861.AZSU01000006_gene1327	7.295e-35	138.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,247Q5@186801|Clostridia,36FN2@31979|Clostridiaceae	186801|Clostridia	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	acoC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,CMD,E3_binding
CMS3_k127_6554067_0	1125863.JAFN01000001_gene456	5.96e-87	293.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2WIZZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
CMS3_k127_6554067_4	47839.CCAU010000008_gene2069	1.657e-05	55.0	COG2755@1|root,COG2755@2|Bacteria,2GJUC@201174|Actinobacteria,233K4@1762|Mycobacteriaceae	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS3_k127_6554067_1	926550.CLDAP_16210	3.335e-72	251.0	COG0572@1|root,COG0572@2|Bacteria,2G6D5@200795|Chloroflexi	200795|Chloroflexi	F	Cytidine monophosphokinase	udk	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
CMS3_k127_6554067_2	446462.Amir_5813	6.278e-16	87.0	COG3595@1|root,COG3595@2|Bacteria,2HIX2@201174|Actinobacteria,4DYUW@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS3_k127_6554067_3	1123065.ATWL01000004_gene2890	6.939e-10	66.0	COG4226@1|root,COG4226@2|Bacteria,2IKXB@201174|Actinobacteria	201174|Actinobacteria	S	protein encoded in hypervariable junctions of pilus gene clusters	-	-	-	-	-	-	-	-	-	-	-	-	HicB,RHH_1
CMS3_k127_6618153_6	543632.JOJL01000027_gene2695	1.624e-13	78.0	COG2197@1|root,COG2197@2|Bacteria,2GW8G@201174|Actinobacteria,4DJTR@85008|Micromonosporales	201174|Actinobacteria	KT	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6618153_0	562973.HMPREF0059_02100	5.847e-148	486.0	COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4D4H7@85005|Actinomycetales	201174|Actinobacteria	J	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
CMS3_k127_6618153_2	698769.JFBD01000028_gene1253	4.831e-79	278.0	COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,4H9K9@91061|Bacilli,4C4I9@84406|Virgibacillus	91061|Bacilli	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CMS3_k127_6618153_5	1128421.JAGA01000002_gene1688	2.918e-54	201.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	-	-	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
CMS3_k127_6618153_3	1458275.AZ34_17685	9.165e-71	253.0	COG1672@1|root,COG1672@2|Bacteria,1MWQD@1224|Proteobacteria,2VK8E@28216|Betaproteobacteria,4ADU1@80864|Comamonadaceae	28216|Betaproteobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
CMS3_k127_6618153_4	471852.Tcur_3321	5.611e-61	220.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4EHD9@85012|Streptosporangiales	201174|Actinobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2773c	DapB_C,DapB_N
CMS3_k127_6618153_1	105420.BBPO01000089_gene4857	1.815e-117	391.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,2NGPG@228398|Streptacidiphilus	201174|Actinobacteria	S	Insulinase (Peptidase family M16)	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_6618153_7	1121019.AUMN01000009_gene1947	9.224e-05	54.0	COG1073@1|root,COG1073@2|Bacteria,2IPZT@201174|Actinobacteria	201174|Actinobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,DLH,Hydrolase_4
CMS3_k127_6647716_0	1179773.BN6_16710	2.495e-210	671.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4E13K@85010|Pseudonocardiales	201174|Actinobacteria	L	DEAD DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
CMS3_k127_6647716_8	644283.Micau_5930	5.29e-16	91.0	COG0637@1|root,COG0637@2|Bacteria,2I2XT@201174|Actinobacteria,4DMIF@85008|Micromonosporales	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	Hydrolase
CMS3_k127_6647716_5	396588.Tgr7_2551	1.807e-46	172.0	COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,1RS9U@1236|Gammaproteobacteria,1WY1P@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions	-	-	-	ko:K02553	-	-	-	-	ko00000,ko03019	-	-	-	RraA-like
CMS3_k127_6647716_2	1463881.KL591008_gene2018	2.57e-71	249.0	COG0663@1|root,COG0663@2|Bacteria,2GP22@201174|Actinobacteria	201174|Actinobacteria	K	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
CMS3_k127_6647716_3	582515.KR51_00018030	5.528e-63	225.0	COG0434@1|root,COG0434@2|Bacteria,1G0P7@1117|Cyanobacteria	1117|Cyanobacteria	S	TIGRFAM membrane complex biogenesis protein, BtpA family	btpA	-	-	ko:K06971	-	-	-	-	ko00000	-	-	-	BtpA
CMS3_k127_6647716_4	298654.FraEuI1c_3598	1.514e-46	177.0	28HG7@1|root,32T0H@2|Bacteria,2IFQ1@201174|Actinobacteria,4EVYV@85013|Frankiales	201174|Actinobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
CMS3_k127_6647716_1	118005.AWNK01000006_gene1372	2.402e-86	297.0	COG1611@1|root,COG1611@2|Bacteria	2|Bacteria	S	cytokinin biosynthetic process	fas6	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS3_k127_6647716_6	1120949.KB903306_gene7439	2.249e-46	178.0	COG0546@1|root,COG0546@2|Bacteria,2GNCU@201174|Actinobacteria,4DC5V@85008|Micromonosporales	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD,HAD_2,Hydrolase_like
CMS3_k127_6647716_7	1121946.AUAX01000004_gene928	3.126e-32	139.0	COG0454@1|root,COG0456@2|Bacteria,2HW3C@201174|Actinobacteria,4DI9Y@85008|Micromonosporales	201174|Actinobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_6647716_10	573065.Astex_1084	1.193e-12	79.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2TS1Z@28211|Alphaproteobacteria,2KF2M@204458|Caulobacterales	204458|Caulobacterales	S	TIGRFAM cobalt chelatase, pCobS small subunit	-	-	6.6.1.2	ko:K09882	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	AAA_5,CbbQ_C,CobS_N
CMS3_k127_6647716_11	626418.bglu_2g03100	7.168e-06	58.0	COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2W642@28216|Betaproteobacteria,1KGXD@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Cobalamin biosynthesis protein CobT VWA domain	-	-	6.6.1.2	ko:K09883	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobT_C
CMS3_k127_6654748_0	316056.RPC_0345	2.371e-117	384.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TS0T@28211|Alphaproteobacteria,3JRJ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	phosphoribosylaminoimidazole-succinocarboxamide synthase	purC2	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
CMS3_k127_6654748_1	861299.J421_3375	1.846e-61	218.0	COG0688@1|root,COG0688@2|Bacteria,1ZU9Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
CMS3_k127_6654748_2	379066.GAU_1734	6.638e-54	204.0	COG1183@1|root,COG1183@2|Bacteria,1ZTJP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
CMS3_k127_6673171_3	1120936.KB907209_gene1422	9.457e-39	152.0	COG1595@1|root,COG1595@2|Bacteria,2IKVM@201174|Actinobacteria,4EJS8@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6673171_1	448385.sce8915	3.918e-72	256.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2WJDR@28221|Deltaproteobacteria,2YUC9@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_6673171_0	867903.ThesuDRAFT_01196	2.346e-94	331.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia	186801|Clostridia	C	dehydrogenase, E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
CMS3_k127_6673171_2	797114.C475_03009	4.482e-68	253.0	COG0022@1|root,arCOG01052@2157|Archaea,2XT3K@28890|Euryarchaeota,23SKR@183963|Halobacteria	183963|Halobacteria	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	pdhB1	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS3_k127_6673655_27	1146883.BLASA_2870	1.445e-06	51.0	2C59E@1|root,2ZDAY@2|Bacteria	2|Bacteria	S	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
CMS3_k127_6673655_23	1123075.AUDP01000012_gene3498	1.582e-13	78.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,3WGIW@541000|Ruminococcaceae	186801|Clostridia	IQ	reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
CMS3_k127_6673655_28	1122182.KB903834_gene5863	0.0005064	46.0	COG1028@1|root,COG1028@2|Bacteria,2GKW9@201174|Actinobacteria,4D9G6@85008|Micromonosporales	201174|Actinobacteria	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_6673655_26	1144310.PMI07_006476	8.232e-09	58.0	COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria,4BNVM@82115|Rhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.53	ko:K00038	ko00140,ko01100,map00140,map01100	-	R04831,R04834,R04844,R04847	RC00139,RC01219,RC01220	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
CMS3_k127_6673655_12	1122247.C731_4953	1.731e-37	151.0	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,2378P@1762|Mycobacteriaceae	201174|Actinobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	garR	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
CMS3_k127_6673655_18	693444.D782_1273	2.046e-21	108.0	COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,1RY5G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_6673655_20	222534.KB893715_gene1700	1.037e-17	85.0	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria,4ESYD@85013|Frankiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_6673655_6	1123320.KB889746_gene8003	6.286e-82	287.0	COG0477@1|root,COG0477@2|Bacteria,2GKFJ@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	ko:K08225	-	-	-	-	ko00000,ko02000	2.A.1.38	-	-	MFS_3
CMS3_k127_6673655_21	1234364.AMSF01000015_gene3300	3.851e-16	83.0	COG1359@1|root,COG1359@2|Bacteria,1N8A9@1224|Proteobacteria,1SGVW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
CMS3_k127_6673655_22	1366046.HIMB11_02092	1.587e-14	82.0	COG2128@1|root,COG2128@2|Bacteria,1NFKC@1224|Proteobacteria,2TQSD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	decarboxylase	MA20_22785	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
CMS3_k127_6673655_9	1194972.MVAC_10122	1.666e-43	168.0	COG1802@1|root,COG1802@2|Bacteria,2GKH7@201174|Actinobacteria,236SS@1762|Mycobacteriaceae	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS3_k127_6673655_7	570952.ATVH01000015_gene1306	5.385e-56	209.0	COG0697@1|root,COG0697@2|Bacteria,1P38S@1224|Proteobacteria,2U1BY@28211|Alphaproteobacteria,2JQWZ@204441|Rhodospirillales	204441|Rhodospirillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_6673655_14	1122603.ATVI01000009_gene2716	3.239e-36	140.0	COG0737@1|root,COG2931@1|root,COG0737@2|Bacteria,COG2931@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1X88H@135614|Xanthomonadales	135614|Xanthomonadales	F	5'-nucleotidase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Metallophos
CMS3_k127_6673655_2	1313172.YM304_03270	1.227e-128	431.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4CNI4@84992|Acidimicrobiia	84992|Acidimicrobiia	JKL	DEAD-like helicases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
CMS3_k127_6673655_15	644966.Tmar_2032	4.621e-29	123.0	COG1495@1|root,COG1495@2|Bacteria,1V79S@1239|Firmicutes,253UQ@186801|Clostridia	186801|Clostridia	C	PFAM Disulfide bond formation protein DsbB	-	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
CMS3_k127_6673655_19	1229780.BN381_350095	5.993e-18	87.0	COG0526@1|root,COG0526@2|Bacteria,2H8ZP@201174|Actinobacteria	201174|Actinobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6673655_3	351607.Acel_0883	7.516e-124	408.0	COG0388@1|root,COG0388@2|Bacteria,2H03Y@201174|Actinobacteria,4EVT7@85013|Frankiales	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.5.1,3.5.5.7	ko:K01501,ko:K01502	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05358,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC01336,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
CMS3_k127_6673655_17	877455.Metbo_1723	2.167e-27	120.0	COG3548@1|root,arCOG04887@2157|Archaea,2XUMU@28890|Euryarchaeota,23PS6@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
CMS3_k127_6673655_4	366602.Caul_4465	1.297e-89	301.0	COG1024@1|root,COG1024@2|Bacteria,1NDT7@1224|Proteobacteria,2U2R9@28211|Alphaproteobacteria,2KGBJ@204458|Caulobacterales	204458|Caulobacterales	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_6673655_5	500153.JOEK01000009_gene5062	3.661e-83	284.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_6673655_10	1429046.RR21198_1254	6.881e-43	166.0	2CK59@1|root,32VV2@2|Bacteria,2I7N7@201174|Actinobacteria,4G9UM@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6673655_25	479432.Sros_6523	1.038e-09	68.0	COG0457@1|root,COG0457@2|Bacteria	479432.Sros_6523|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6673655_16	450851.PHZ_c0812	2.957e-28	118.0	COG3794@1|root,COG3794@2|Bacteria,1QWIK@1224|Proteobacteria,2TWY9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
CMS3_k127_6673655_0	292459.STH1426	9.946e-178	575.0	COG1132@1|root,COG1132@2|Bacteria,1TRCZ@1239|Firmicutes,24C4R@186801|Clostridia	186801|Clostridia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_6673655_1	1007103.AFHW01000145_gene4105	2.204e-162	534.0	COG1132@1|root,COG1132@2|Bacteria,1UZA0@1239|Firmicutes,4HC2E@91061|Bacilli,26VPZ@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
CMS3_k127_6673655_8	215803.DB30_1677	1.41e-46	184.0	COG1073@1|root,COG1073@2|Bacteria,1Q31F@1224|Proteobacteria,438RK@68525|delta/epsilon subdivisions,2X999@28221|Deltaproteobacteria,2YXKS@29|Myxococcales	28221|Deltaproteobacteria	S	Abhydrolase domain containing 18	-	-	-	-	-	-	-	-	-	-	-	-	DUF2048
CMS3_k127_6673655_11	3067.XP_002958724.1	3.115e-39	151.0	COG0225@1|root,COG0545@1|root,KOG0544@2759|Eukaryota,KOG1635@2759|Eukaryota,37JIQ@33090|Viridiplantae,34ID2@3041|Chlorophyta	3041|Chlorophyta	O	Peptide methionine sulfoxide reductase	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C,PMSR
CMS3_k127_668894_18	457425.XNR_2278	2.193e-24	109.0	2DMA2@1|root,32B92@2|Bacteria,2IMA7@201174|Actinobacteria	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
CMS3_k127_668894_5	1382356.JQMP01000001_gene1210	1.95e-107	362.0	COG0001@1|root,COG0001@2|Bacteria,2G67D@200795|Chloroflexi,27XJ3@189775|Thermomicrobia	189775|Thermomicrobia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_668894_15	266265.Bxe_B1965	1.192e-39	151.0	COG0599@1|root,COG0599@2|Bacteria,1RJU6@1224|Proteobacteria,2W36K@28216|Betaproteobacteria,1K73E@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
CMS3_k127_668894_23	1303518.CCALI_00056	2.976e-17	90.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CaMKII_AD,DUF4440,SnoaL_2,SnoaL_3,SnoaL_4
CMS3_k127_668894_4	1337093.MBE-LCI_1744	3.898e-111	378.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TUVG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_668894_11	1122182.KB903836_gene4982	1.058e-47	177.0	COG0346@1|root,COG0346@2|Bacteria,2IFBN@201174|Actinobacteria,4DGJ9@85008|Micromonosporales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_668894_8	323097.Nham_3239	6.499e-77	261.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2U9HZ@28211|Alphaproteobacteria,3K0YK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044424,GO:0044464	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
CMS3_k127_668894_14	1313172.YM304_26180	3.502e-40	156.0	COG2802@1|root,COG2802@2|Bacteria,2GNWA@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase S16, lon domain protein	-	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
CMS3_k127_668894_0	1121946.AUAX01000005_gene5377	8.427e-241	755.0	COG0520@1|root,COG0520@2|Bacteria,2GP7W@201174|Actinobacteria,4DAKS@85008|Micromonosporales	201174|Actinobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_668894_16	1043493.BBLU01000005_gene2022	9.661e-27	123.0	COG5646@1|root,COG5646@2|Bacteria	2|Bacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
CMS3_k127_668894_2	331869.BAL199_21644	2.379e-169	540.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2TRS9@28211|Alphaproteobacteria,4BPN9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	dgoD	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
CMS3_k127_668894_22	756272.Plabr_2113	3.523e-18	87.0	2BZBR@1|root,32YH6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
CMS3_k127_668894_6	1122182.KB903839_gene1125	2.446e-99	336.0	COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria,4DC3S@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
CMS3_k127_668894_12	266940.Krad_1636	6.715e-47	177.0	COG2071@1|root,COG2071@2|Bacteria,2GIV6@201174|Actinobacteria	201174|Actinobacteria	K	peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
CMS3_k127_668894_27	477974.Daud_1410	0.0003551	50.0	COG3599@1|root,COG3599@2|Bacteria,1V27M@1239|Firmicutes,24MM3@186801|Clostridia,262G3@186807|Peptococcaceae	186801|Clostridia	D	PFAM DivIVA	divIVA	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
CMS3_k127_668894_17	1172181.KB911699_gene1473	2.343e-25	117.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria	201174|Actinobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
CMS3_k127_668894_13	1123322.KB904703_gene59	3.736e-44	172.0	COG0454@1|root,COG0456@2|Bacteria,2GM35@201174|Actinobacteria	201174|Actinobacteria	K	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol	mshD	GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
CMS3_k127_668894_26	350688.Clos_2404	0.0002622	52.0	COG0510@1|root,COG0510@2|Bacteria,1TQ5R@1239|Firmicutes,25CDY@186801|Clostridia,36GQ3@31979|Clostridiaceae	186801|Clostridia	M	choline ethanolamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Choline_kinase,HTH_24,NTP_transf_3
CMS3_k127_668894_1	1229780.BN381_50171	8.167e-218	693.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,3UW80@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
CMS3_k127_668894_9	439481.Aboo_0020	1.738e-70	269.0	COG1033@1|root,arCOG02174@2157|Archaea,2XT5A@28890|Euryarchaeota,3F2U6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Patched family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS3_k127_668894_7	439481.Aboo_0020	9.797e-84	310.0	COG1033@1|root,arCOG02174@2157|Archaea,2XT5A@28890|Euryarchaeota,3F2U6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Patched family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS3_k127_668894_21	1313172.YM304_19740	1.375e-19	96.0	2F9Q3@1|root,34209@2|Bacteria,2H616@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_668894_24	1123321.KB905816_gene2628	1.207e-11	69.0	COG3593@1|root,COG3593@2|Bacteria,2GMN5@201174|Actinobacteria	201174|Actinobacteria	L	DNA synthesis involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_668894_3	479431.Namu_4703	1.036e-161	534.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4ESB0@85013|Frankiales	201174|Actinobacteria	C	Belongs to the citrate synthase family	gltA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
CMS3_k127_668894_19	525245.HMPREF0044_1349	1.816e-23	107.0	COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4D4D1@85005|Actinomycetales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.11,2.7.8.5	ko:K00995,ko:K00999	ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070	-	R01801,R01802	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS3_k127_668894_10	1996.JOFO01000006_gene451	5.471e-54	203.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4EHU2@85012|Streptosporangiales	201174|Actinobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
CMS3_k127_668894_20	411466.ACTODO_01425	1.019e-21	102.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,4D3G5@85005|Actinomycetales	201174|Actinobacteria	M	Glycosyltransferase, group 1 family protein	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
CMS3_k127_6775081_1	44060.JODL01000015_gene5241	1.901e-22	107.0	COG0470@1|root,COG0470@2|Bacteria,2GJ8C@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase III	holB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
CMS3_k127_6775081_2	1120958.AULD01000006_gene425	5.888e-13	79.0	COG0204@1|root,COG0204@2|Bacteria,2GKVA@201174|Actinobacteria,4FKY5@85023|Microbacteriaceae	201174|Actinobacteria	I	Phosphate acyltransferases	plsC2	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS3_k127_6775081_0	1133850.SHJG_3669	6.921e-72	250.0	COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria	201174|Actinobacteria	S	epimerase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
CMS3_k127_6779505_0	1380393.JHVP01000005_gene3634	3.014e-138	469.0	COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria,4EU4Q@85013|Frankiales	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
CMS3_k127_6779505_1	1410625.JHWK01000002_gene39	3.566e-06	55.0	COG2179@1|root,COG2179@2|Bacteria,1V6KM@1239|Firmicutes,24KK7@186801|Clostridia,27JDV@186928|unclassified Lachnospiraceae	186801|Clostridia	F	HAD-hyrolase-like	yqeG	-	-	ko:K07015	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase,Hydrolase_like,PGP_phosphatase
CMS3_k127_6792063_4	529818.AMSG_12001T0	4.352e-05	57.0	COG0708@1|root,COG5069@1|root,KOG0035@2759|Eukaryota,KOG1294@2759|Eukaryota	2759|Eukaryota	L	double-stranded DNA 3'-5' exodeoxyribonuclease activity	-	GO:0000003,GO:0000139,GO:0000278,GO:0000281,GO:0000902,GO:0000904,GO:0000910,GO:0000916,GO:0001932,GO:0001934,GO:0002064,GO:0003382,GO:0003674,GO:0003779,GO:0005488,GO:0005515,GO:0005543,GO:0005546,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005795,GO:0005815,GO:0005819,GO:0005826,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0006935,GO:0006950,GO:0006996,GO:0007010,GO:0007015,GO:0007049,GO:0007154,GO:0007155,GO:0007275,GO:0008092,GO:0008104,GO:0008150,GO:0008289,GO:0009267,GO:0009581,GO:0009582,GO:0009605,GO:0009612,GO:0009628,GO:0009653,GO:0009847,GO:0009888,GO:0009893,GO:0009987,GO:0009991,GO:0010324,GO:0010468,GO:0010562,GO:0010604,GO:0010628,GO:0010638,GO:0012505,GO:0015629,GO:0015630,GO:0016020,GO:0016043,GO:0019220,GO:0019222,GO:0019953,GO:0022402,GO:0022414,GO:0022607,GO:0022610,GO:0030029,GO:0030036,GO:0030154,GO:0030587,GO:0030855,GO:0030863,GO:0030864,GO:0030865,GO:0030866,GO:0031032,GO:0031090,GO:0031150,GO:0031152,GO:0031154,GO:0031252,GO:0031254,GO:0031255,GO:0031288,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0031667,GO:0031668,GO:0031669,GO:0031965,GO:0031967,GO:0031975,GO:0031982,GO:0031984,GO:0031985,GO:0032153,GO:0032154,GO:0032155,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032506,GO:0032580,GO:0032956,GO:0032970,GO:0032989,GO:0033036,GO:0033043,GO:0033554,GO:0034613,GO:0035091,GO:0036089,GO:0036213,GO:0036360,GO:0040011,GO:0042175,GO:0042221,GO:0042325,GO:0042327,GO:0042330,GO:0042594,GO:0042802,GO:0042803,GO:0043087,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043254,GO:0043327,GO:0043519,GO:0043520,GO:0044085,GO:0044087,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044430,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044448,GO:0044459,GO:0044464,GO:0044703,GO:0044764,GO:0044837,GO:0044877,GO:0045178,GO:0045180,GO:0045184,GO:0045937,GO:0046983,GO:0048468,GO:0048518,GO:0048522,GO:0048856,GO:0048869,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0050982,GO:0051015,GO:0051017,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051233,GO:0051234,GO:0051246,GO:0051247,GO:0051301,GO:0051336,GO:0051493,GO:0051495,GO:0051606,GO:0051639,GO:0051641,GO:0051703,GO:0051704,GO:0051716,GO:0060255,GO:0060429,GO:0061024,GO:0061572,GO:0061640,GO:0065007,GO:0065009,GO:0070727,GO:0070938,GO:0071496,GO:0071840,GO:0071944,GO:0072657,GO:0072686,GO:0072741,GO:0080090,GO:0090702,GO:0097435,GO:0097574,GO:0098588,GO:0098590,GO:0098609,GO:0098630,GO:0098743,GO:0098791,GO:0098827,GO:0099024,GO:0099120,GO:0099568,GO:0099738,GO:1901981,GO:1902936,GO:1903047,GO:1905345,GO:1990023,GO:1990778	3.1.11.2,4.2.99.18	ko:K01142,ko:K05699,ko:K10771,ko:K18620	ko03410,ko04510,ko04520,ko04530,ko04670,ko04810,ko05146,ko05203,ko05322,map03410,map04510,map04520,map04530,map04670,map04810,map05146,map05203,map05322	M00296	-	-	ko00000,ko00001,ko00002,ko01000,ko03400,ko04131,ko04147,ko04812	-	-	-	CH,Cortex-I_coil,Exo_endo_phos
CMS3_k127_6792063_5	479435.Kfla_4990	9.957e-05	56.0	COG1196@1|root,COG1196@2|Bacteria,2I579@201174|Actinobacteria,4DWXY@85009|Propionibacteriales	201174|Actinobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	DivIVA
CMS3_k127_6792063_1	1172180.KB911792_gene3677	3.966e-177	560.0	COG1830@1|root,COG1830@2|Bacteria,2I9V1@201174|Actinobacteria	201174|Actinobacteria	G	PFAM deoxyribose-phosphate aldolase phospho-2- dehydro-3-deoxyheptonate aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
CMS3_k127_6792063_2	246197.MXAN_5717	3.901e-130	435.0	COG1109@1|root,COG1109@2|Bacteria,1QUGD@1224|Proteobacteria,43BUU@68525|delta/epsilon subdivisions,2WKYP@28221|Deltaproteobacteria,2YTV9@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II	-	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS3_k127_6792063_0	656024.FsymDg_1329	1.533e-215	686.0	COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4ES07@85013|Frankiales	201174|Actinobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
CMS3_k127_6792063_3	1254432.SCE1572_09945	1.043e-108	368.0	COG5555@1|root,COG5555@2|Bacteria,1QX82@1224|Proteobacteria,43CYG@68525|delta/epsilon subdivisions,2X86M@28221|Deltaproteobacteria,2Z3M6@29|Myxococcales	28221|Deltaproteobacteria	N	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP
CMS3_k127_679486_16	502558.EGYY_13340	1.52e-22	109.0	COG1232@1|root,COG1232@2|Bacteria,2I0C8@201174|Actinobacteria,4CXDQ@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_679486_18	216594.MMAR_2066	1.175e-18	96.0	COG3945@1|root,COG3945@2|Bacteria	2|Bacteria	P	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
CMS3_k127_679486_14	452863.Achl_1114	2.719e-30	131.0	2AFVV@1|root,33H4H@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_679486_13	1078020.KEK_07317	3.105e-32	132.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,234FU@1762|Mycobacteriaceae	201174|Actinobacteria	L	Transposase, mutator	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
CMS3_k127_679486_20	314287.GB2207_00280	2.027e-10	68.0	COG3787@1|root,COG3787@2|Bacteria	2|Bacteria	S	Belongs to the UPF0306 family	-	-	-	ko:K09979	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
CMS3_k127_679486_22	1454004.AW11_01670	1.467e-09	65.0	COG0604@1|root,COG2905@1|root,COG0604@2|Bacteria,COG2905@2|Bacteria,1MXIK@1224|Proteobacteria,2W1P8@28216|Betaproteobacteria	28216|Betaproteobacteria	CT	Domain in cystathionine beta-synthase and other proteins.	-	-	1.3.1.85	ko:K14446	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09291	RC02481	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N,CBS
CMS3_k127_679486_21	211114.JOEF01000001_gene7406	5.242e-10	71.0	COG1502@1|root,COG1502@2|Bacteria,2IBN6@201174|Actinobacteria,4E5AY@85010|Pseudonocardiales	201174|Actinobacteria	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
CMS3_k127_679486_9	653045.Strvi_5056	7.914e-53	211.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator, SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NB-ARC,TPR_10,TPR_12,TPR_7,TPR_8,Trans_reg_C
CMS3_k127_679486_24	58344.JOEL01000044_gene886	0.0002146	48.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria	201174|Actinobacteria	I	hydrolase	-	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
CMS3_k127_679486_1	1121877.JQKF01000026_gene2444	3.989e-202	651.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CNJF@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
CMS3_k127_679486_3	1127134.NOCYR_2205	1.659e-116	395.0	COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,4FUTC@85025|Nocardiaceae	201174|Actinobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	Cytidylate_kin,KH_dom-like,MMR_HSR1
CMS3_k127_679486_2	1313172.YM304_25530	3.653e-131	434.0	COG1625@1|root,COG1625@2|Bacteria,2H3RR@201174|Actinobacteria,4CMW9@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Protein of unknown function (DUF512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
CMS3_k127_679486_4	1313172.YM304_25520	9.389e-97	328.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4CMP7@84992|Acidimicrobiia	84992|Acidimicrobiia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
CMS3_k127_679486_10	1223544.GSI01S_47_00030	9.761e-47	181.0	COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,4GCWB@85026|Gordoniaceae	201174|Actinobacteria	F	Cytidylate kinase	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0040007,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
CMS3_k127_679486_5	765420.OSCT_1394	3.672e-85	307.0	COG0128@1|root,COG0128@2|Bacteria,2G5TT@200795|Chloroflexi,375C6@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
CMS3_k127_679486_8	1229780.BN381_290070	7.535e-63	224.0	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,3UWKC@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	RNA pseudouridylate synthase	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS3_k127_679486_11	1313172.YM304_24970	9.324e-44	168.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4CN9J@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
CMS3_k127_679486_12	211114.JOEF01000008_gene1350	6.256e-43	167.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria,4DXFN@85010|Pseudonocardiales	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
CMS3_k127_679486_19	1298863.AUEP01000020_gene3620	1.447e-13	75.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4DRE5@85009|Propionibacteriales	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
CMS3_k127_679486_7	103733.JNYO01000003_gene8351	6.394e-77	268.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4DYBT@85010|Pseudonocardiales	201174|Actinobacteria	L	Tyrosine recombinase XerD	xerD	GO:0008150,GO:0040007	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS3_k127_679486_15	391037.Sare_1912	3.248e-30	128.0	COG0494@1|root,COG0494@2|Bacteria,2GNW6@201174|Actinobacteria,4D9G2@85008|Micromonosporales	201174|Actinobacteria	L	Nudix hydrolase	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
CMS3_k127_679486_0	536227.CcarbDRAFT_2770	9.1e-225	708.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,36DBK@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
CMS3_k127_679486_6	926560.KE387023_gene2754	2.095e-79	287.0	COG0497@1|root,COG0497@2|Bacteria,1WI2N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	May be involved in recombinational repair of damaged DNA	recN	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
CMS3_k127_679486_17	365528.KB891223_gene1301	1.536e-21	96.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4ES4X@85013|Frankiales	201174|Actinobacteria	J	Ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
CMS3_k127_6823038_5	309801.trd_1134	2.799e-48	188.0	COG1921@1|root,COG1921@2|Bacteria	2|Bacteria	E	L-seryl-tRNASec selenium transferase activity	-	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,Cys_Met_Meta_PP,SelA
CMS3_k127_6823038_0	521096.Tpau_0381	5.263e-280	878.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria	201174|Actinobacteria	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.5.8.1,1.5.8.2	ko:K00317	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R01588,R02511	RC00185,RC00556,RC00557,RC00732	ko00000,ko00001,ko01000	-	-	-	NAD_binding_8,Oxidored_FMN,Pyr_redox_2
CMS3_k127_6823038_1	1121918.ARWE01000001_gene1360	4.471e-192	610.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2X70U@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	E	PFAM Cys Met metabolism	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
CMS3_k127_6823038_6	118163.Ple7327_0421	1.553e-45	169.0	COG1522@1|root,COG1522@2|Bacteria,1G9VY@1117|Cyanobacteria	1117|Cyanobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
CMS3_k127_6823038_2	1297570.MESS4_750064	1.355e-121	404.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TRWG@28211|Alphaproteobacteria,43I37@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C
CMS3_k127_6823038_4	1489678.RDMS_11110	9.264e-56	202.0	COG1926@1|root,COG1926@2|Bacteria,1WKAM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
CMS3_k127_6823038_7	468556.AQYG01000045_gene1847	3.077e-43	173.0	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4GEH4@85026|Gordoniaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_6823038_10	196490.AUEZ01000055_gene261	0.0001145	48.0	COG3360@1|root,COG3360@2|Bacteria,1N6UT@1224|Proteobacteria,2UFCS@28211|Alphaproteobacteria,3K077@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
CMS3_k127_6823038_9	1173028.ANKO01000064_gene3081	5.865e-35	148.0	COG0477@1|root,COG0477@2|Bacteria,1GHCR@1117|Cyanobacteria,1H7ZA@1150|Oscillatoriales	1117|Cyanobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
CMS3_k127_6823038_8	28072.Nos7524_1364	3.105e-38	151.0	COG0477@1|root,COG0477@2|Bacteria,1GHCR@1117|Cyanobacteria,1HKQS@1161|Nostocales	1117|Cyanobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
CMS3_k127_6823038_3	1382356.JQMP01000001_gene1156	1.121e-110	369.0	COG1060@1|root,COG1060@2|Bacteria,2G7YI@200795|Chloroflexi,27YSR@189775|Thermomicrobia	189775|Thermomicrobia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
CMS3_k127_6917225_3	1410618.JNKI01000002_gene1059	4.378e-58	214.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,4H34E@909932|Negativicutes	909932|Negativicutes	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
CMS3_k127_6917225_1	1223544.GSI01S_09_00460	3.553e-77	269.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4GC5S@85026|Gordoniaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_6917225_4	1120950.KB892775_gene1195	4.716e-36	158.0	COG0477@1|root,COG2814@2|Bacteria,2GKRT@201174|Actinobacteria,4DNAP@85009|Propionibacteriales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_6917225_0	1282876.BAOK01000001_gene3449	2.775e-98	331.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2TT75@28211|Alphaproteobacteria,4BP8N@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus	gpsA	GO:0003674,GO:0003824,GO:0006072,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
CMS3_k127_6917225_2	290397.Adeh_2154	3.421e-76	263.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,42ZH7@68525|delta/epsilon subdivisions,2WV12@28221|Deltaproteobacteria,2Z0K0@29|Myxococcales	28221|Deltaproteobacteria	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
CMS3_k127_6917225_5	543728.Vapar_1978	3.436e-32	132.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria,4ACF1@80864|Comamonadaceae	28216|Betaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
CMS3_k127_6927448_12	977880.RALTA_B2256	9.894e-05	49.0	28HCU@1|root,2Z7PM@2|Bacteria,1MXCC@1224|Proteobacteria,2VMUA@28216|Betaproteobacteria,1K951@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6927448_0	419947.MRA_1057	1.981e-58	216.0	COG4861@1|root,COG4861@2|Bacteria,2H1DQ@201174|Actinobacteria	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_2
CMS3_k127_6927448_2	1448139.AI20_02565	7.66e-54	197.0	COG0110@1|root,COG0110@2|Bacteria,1RKM6@1224|Proteobacteria,1S7HK@1236|Gammaproteobacteria,1Y6EU@135624|Aeromonadales	135624|Aeromonadales	S	Maltose acetyltransferase	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2,Mac
CMS3_k127_6927448_1	1237149.C900_01842	4.375e-58	215.0	2C2FI@1|root,32T83@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6927448_13	1536774.H70357_03950	0.000368	49.0	COG1695@1|root,COG1695@2|Bacteria,1VA8U@1239|Firmicutes,4HKPC@91061|Bacilli,26Z28@186822|Paenibacillaceae	91061|Bacilli	K	transcriptional	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
CMS3_k127_6927448_9	1313172.YM304_05710	1.101e-09	65.0	COG1808@1|root,COG1808@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
CMS3_k127_6927448_11	290399.Arth_1741	3.911e-06	50.0	COG3263@1|root,COG3263@2|Bacteria,2GJ9B@201174|Actinobacteria,1WAER@1268|Micrococcaceae	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
CMS3_k127_6927448_5	1122238.AULR01000008_gene848	3.85e-30	121.0	COG2261@1|root,COG2261@2|Bacteria,2GQR5@201174|Actinobacteria,4FQ3U@85023|Microbacteriaceae	201174|Actinobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
CMS3_k127_6927448_4	384765.SIAM614_07133	1.253e-33	133.0	COG2329@1|root,COG2329@2|Bacteria,1N2ZS@1224|Proteobacteria,2UEPY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6927448_10	1122915.AUGY01000011_gene3991	3.068e-06	51.0	28PQP@1|root,2ZCCM@2|Bacteria,1V1II@1239|Firmicutes,4HGJG@91061|Bacilli,26T2P@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
CMS3_k127_6927448_6	994479.GL877878_gene2228	4.224e-29	124.0	COG1518@1|root,COG3293@1|root,COG1518@2|Bacteria,COG3293@2|Bacteria	2|Bacteria	L	Transposase	cas1	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1,DUF4096
CMS3_k127_6927448_7	35754.JNYJ01000002_gene6880	2.174e-26	116.0	2DG2H@1|root,32U6K@2|Bacteria,2IQJX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6927448_8	32057.KB217482_gene8706	2.48e-13	75.0	COG0454@1|root,COG0456@2|Bacteria,1GJH2@1117|Cyanobacteria,1HRW5@1161|Nostocales	1117|Cyanobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6935674_1	1499967.BAYZ01000028_gene1233	8.181e-38	156.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14
CMS3_k127_6935674_0	867845.KI911784_gene2277	8.312e-75	270.0	COG0457@1|root,COG1404@1|root,COG3055@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,COG3055@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
CMS3_k127_6957638_2	1313172.YM304_20400	1.251e-38	163.0	COG3463@1|root,COG3463@2|Bacteria	2|Bacteria	T	Predicted membrane protein (DUF2079)	-	-	2.7.13.3	ko:K07778	ko02020,map02020	M00479	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF2079,HisKA_3
CMS3_k127_6957638_1	216594.MMAR_1373	1.413e-108	360.0	COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria,233GJ@1762|Mycobacteriaceae	201174|Actinobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_32,rve,rve_3
CMS3_k127_6957638_0	1121377.KB906436_gene921	6.055e-133	455.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
CMS3_k127_6957638_3	56110.Oscil6304_1312	1.145e-19	96.0	28N7T@1|root,2ZBCE@2|Bacteria,1G50K@1117|Cyanobacteria,1H966@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6978672_4	552811.Dehly_1295	2.402e-60	213.0	COG1131@1|root,COG1131@2|Bacteria,2G6HN@200795|Chloroflexi,34D7R@301297|Dehalococcoidia	301297|Dehalococcoidia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_6978672_3	1125863.JAFN01000001_gene1864	7.565e-105	353.0	COG1748@1|root,COG1748@2|Bacteria,1MY1G@1224|Proteobacteria,43B3P@68525|delta/epsilon subdivisions,2WM2X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
CMS3_k127_6978672_12	748280.NH8B_1561	3.764e-27	115.0	COG1359@1|root,COG1359@2|Bacteria,1NBVY@1224|Proteobacteria,2W67Z@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
CMS3_k127_6978672_13	1232410.KI421416_gene2675	2.16e-19	91.0	COG0599@1|root,COG0599@2|Bacteria,1N2ZQ@1224|Proteobacteria,42VDR@68525|delta/epsilon subdivisions,2WRKS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_6978672_0	526225.Gobs_1518	1.153e-185	623.0	COG1215@1|root,COG2199@1|root,COG1215@2|Bacteria,COG3706@2|Bacteria,2GNN5@201174|Actinobacteria,4ETQT@85013|Frankiales	201174|Actinobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Glyco_tranf_2_3,Response_reg
CMS3_k127_6978672_11	1007096.BAGW01000023_gene165	2.815e-27	129.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,2N6CH@216572|Oscillospiraceae	186801|Clostridia	T	PAS domain	yycG	-	2.7.13.3	ko:K07652	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_8,PAS_9
CMS3_k127_6978672_7	351607.Acel_1905	4.971e-39	166.0	COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4ERVM@85013|Frankiales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,HAMP,PAS
CMS3_k127_6978672_5	2002.JOEQ01000019_gene7478	1.74e-54	209.0	COG1316@1|root,COG1316@2|Bacteria,2GM55@201174|Actinobacteria,4EHUC@85012|Streptosporangiales	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
CMS3_k127_6978672_8	479432.Sros_0822	1.076e-38	150.0	COG2318@1|root,COG2318@2|Bacteria,2I1DJ@201174|Actinobacteria,4EK4Y@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
CMS3_k127_6978672_10	1123368.AUIS01000006_gene626	3.874e-32	137.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,1S3WJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Deacetylates O-acetyl-ADP ribose. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization activation	ymdB	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1900190,GO:1900231	-	-	-	-	-	-	-	-	-	-	Macro
CMS3_k127_6978672_6	1120950.KB892820_gene710	2.647e-42	168.0	COG3214@1|root,COG3214@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
CMS3_k127_6978672_2	1151122.AQYD01000006_gene1700	4.181e-146	479.0	COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria	201174|Actinobacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS3_k127_6978672_1	1123320.KB889718_gene7445	8.727e-162	522.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
CMS3_k127_6978672_9	479433.Caci_1549	3.581e-32	134.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
CMS3_k127_7002232_21	1122611.KB903948_gene6717	8.027e-14	83.0	COG0577@1|root,COG0577@2|Bacteria,2GNEX@201174|Actinobacteria,4EI9Q@85012|Streptosporangiales	201174|Actinobacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
CMS3_k127_7002232_5	1122611.KB903948_gene6716	8.676e-110	365.0	COG1136@1|root,COG1136@2|Bacteria,2GIV7@201174|Actinobacteria,4EGJX@85012|Streptosporangiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS3_k127_7002232_9	1150864.MILUP08_41743	8.753e-83	282.0	COG1136@1|root,COG1136@2|Bacteria,2GJQV@201174|Actinobacteria,4D9QK@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_7002232_10	1121028.ARQE01000005_gene2778	3.824e-76	271.0	COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria,2PKZY@255475|Aurantimonadaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	3.13.1.4	ko:K19966	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_7002232_12	1179773.BN6_17770	5.718e-66	236.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4DY5T@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigB	GO:0000988,GO:0000990,GO:0001666,GO:0002791,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009410,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0016020,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032879,GO:0032880,GO:0036293,GO:0040007,GO:0042221,GO:0043175,GO:0043254,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051173,GO:0051223,GO:0051252,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0070063,GO:0070201,GO:0070482,GO:0071944,GO:0080090,GO:0090087,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:1903530,GO:2000112,GO:2000142,GO:2001141	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS3_k127_7002232_0	935840.JAEQ01000003_gene279	4.486e-226	708.0	COG0404@1|root,COG0404@2|Bacteria,1MWZS@1224|Proteobacteria,2TSVD@28211|Alphaproteobacteria,43JE4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Aminomethyltransferase folate-binding domain	-	-	2.1.1.341	ko:K15066	ko00627,ko01120,map00627,map01120	-	R09271,R10136	RC00113,RC00392	ko00000,ko00001,ko01000	-	-	-	GCV_T,GCV_T_C
CMS3_k127_7002232_6	479434.Sthe_0603	9.152e-95	317.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	pcaH	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
CMS3_k127_7002232_15	479434.Sthe_0604	1.194e-51	193.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	pcaG	-	1.13.11.3	ko:K00448	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
CMS3_k127_7002232_3	479434.Sthe_0605	1.127e-129	418.0	COG1788@1|root,COG1788@2|Bacteria,2G6IM@200795|Chloroflexi	200795|Chloroflexi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
CMS3_k127_7002232_4	1500257.JQNM01000008_gene1394	4.636e-116	381.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,2TUZ8@28211|Alphaproteobacteria,4BCK8@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Coenzyme A transferase	catJ	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
CMS3_k127_7002232_13	1437882.AZRU01000042_gene4595	9.236e-66	238.0	COG0015@1|root,COG0015@2|Bacteria,1MXNN@1224|Proteobacteria,1RS00@1236|Gammaproteobacteria,1YCXV@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	F	Adenylosuccinate lyase C-terminus	pcaB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	5.5.1.2	ko:K01857	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03307	RC00902	ko00000,ko00001,ko01000	-	-	-	ADSL_C,Lyase_1
CMS3_k127_7002232_14	1112217.PPL19_13690	8.391e-64	231.0	COG0596@1|root,COG0596@2|Bacteria,1QTTN@1224|Proteobacteria	1224|Proteobacteria	S	hydrolases or acyltransferases, alpha beta hydrolase superfamily	pcaD	-	3.1.1.24,4.1.1.44	ko:K01055,ko:K14727,ko:K19707	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991,R03470	RC00825,RC00938	ko00000,ko00001,ko00002,ko01000,ko03021	-	-	iJN746.PP_1380	Abhydrolase_1
CMS3_k127_7002232_20	1380358.JADJ01000013_gene3430	9.464e-20	99.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Usp
CMS3_k127_7002232_8	1095769.CAHF01000011_gene2117	4.383e-84	287.0	COG3777@1|root,COG3777@2|Bacteria,1P96N@1224|Proteobacteria,2VIUS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	N-terminal half of MaoC dehydratase	-	-	4.2.1.153,4.2.1.56	ko:K09709,ko:K18291	ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200	M00376	R02491,R09282	RC00730,RC02479	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydrat_N
CMS3_k127_7002232_1	383372.Rcas_0911	4.212e-146	473.0	COG1804@1|root,COG1804@2|Bacteria	2|Bacteria	C	formyl-CoA transferase activity	mct	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0015977,GO:0016853,GO:0016866,GO:0016867,GO:0043427,GO:0071704	5.4.1.3	ko:K14470	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00376	R09283	RC02480	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
CMS3_k127_7002232_11	1123319.AUBE01000027_gene4809	2.839e-67	239.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
CMS3_k127_7002232_2	1229780.BN381_210057	1.228e-142	469.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,3UX9W@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1,1.3.8.12	ko:K00248,ko:K14448	ko00071,ko00280,ko00630,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00630,map00650,map01100,map01110,map01120,map01200,map01212	M00373	R01175,R01178,R02661,R03172,R04751,R09293	RC00052,RC00068,RC00076,RC00120,RC00148,RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_7002232_16	547559.Nmag_3457	9.23e-34	147.0	COG2079@1|root,arCOG04285@2157|Archaea,2XTMT@28890|Euryarchaeota,23T4R@183963|Halobacteria	183963|Halobacteria	S	protein involved in propionate catabolism	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
CMS3_k127_7002232_7	867903.ThesuDRAFT_01275	8.81e-87	301.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia,3WD6V@538999|Clostridiales incertae sedis	186801|Clostridia	C	acyl-CoA transferase carnitine dehydratase	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
CMS3_k127_7002232_23	717605.Theco_2847	8.491e-11	72.0	COG2010@1|root,COG2010@2|Bacteria,1VEEP@1239|Firmicutes,4HP6N@91061|Bacilli,26ZR6@186822|Paenibacillaceae	91061|Bacilli	C	Cytochrome C oxidase, cbb3-type, subunit III	cccB	-	-	ko:K12263	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
CMS3_k127_7002232_17	926550.CLDAP_14460	1.615e-31	129.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
CMS3_k127_7002232_19	1313172.YM304_31800	1.674e-28	119.0	COG2010@1|root,COG2010@2|Bacteria,2H614@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
CMS3_k127_7002232_18	1163409.UUA_05407	2.065e-29	120.0	COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,1S9CQ@1236|Gammaproteobacteria,1X7SJ@135614|Xanthomonadales	135614|Xanthomonadales	S	metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF411
CMS3_k127_7002232_22	1122182.KB903814_gene3487	1.589e-13	76.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2H2BE@201174|Actinobacteria,4DHIR@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
CMS3_k127_7025410_0	247490.KSU1_D0507	9.703e-256	816.0	COG2132@1|root,COG2132@2|Bacteria,2J4J4@203682|Planctomycetes	203682|Planctomycetes	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7090979_1	1259795.ARJK01000006_gene644	1.687e-05	55.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia	186801|Clostridia	E	Family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_7090979_0	1137269.AZWL01000006_gene6845	2.872e-96	323.0	COG0588@1|root,COG0588@2|Bacteria,2GK8F@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
CMS3_k127_7117356_3	1395571.TMS3_0103315	8.36e-108	366.0	COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,1RP39@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
CMS3_k127_7117356_9	1089551.KE386572_gene2812	2.761e-33	136.0	COG0824@1|root,COG1250@1|root,COG0824@2|Bacteria,COG1250@2|Bacteria,1MV8M@1224|Proteobacteria,2TRAW@28211|Alphaproteobacteria,4BPFC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	lcdH	-	1.1.1.108	ko:K17735	-	-	-	-	ko00000,ko01000	-	-	-	3HCDH,3HCDH_N,4HBT_2
CMS3_k127_7117356_1	545695.TREAZ_1389	4.954e-228	722.0	COG2759@1|root,COG2759@2|Bacteria,2J5JZ@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
CMS3_k127_7117356_8	1043493.BBLU01000002_gene1863	1.959e-41	164.0	2EJRI@1|root,32U8K@2|Bacteria,2IT18@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
CMS3_k127_7117356_21	485914.Hmuk_2921	2.126e-07	62.0	COG3979@1|root,arCOG07581@2157|Archaea	2157|Archaea	C	PKD domain containing protein	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Glyco_hydro_18,PKD
CMS3_k127_7117356_0	903818.KI912268_gene1122	0.0	1247.0	COG3383@1|root,COG3383@2|Bacteria,3Y2KP@57723|Acidobacteria	57723|Acidobacteria	C	Formate dehydrogenase, alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
CMS3_k127_7117356_2	903818.KI912268_gene1123	1.603e-212	677.0	COG1894@1|root,COG1894@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
CMS3_k127_7117356_6	903818.KI912268_gene1124	4.55e-49	179.0	COG1905@1|root,COG1905@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS3_k127_7117356_10	1038860.AXAP01000001_gene6476	5.579e-31	134.0	COG3427@1|root,COG3427@2|Bacteria,1N4EQ@1224|Proteobacteria,2UJUX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Carbon monoxide dehydrogenase subunit G (CoxG)	-	-	-	-	-	-	-	-	-	-	-	-	COXG
CMS3_k127_7117356_7	591158.SSMG_02437	9.391e-49	186.0	COG0491@1|root,COG0491@2|Bacteria,2GMSA@201174|Actinobacteria	201174|Actinobacteria	S	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_7117356_13	1394178.AWOO02000078_gene2024	3.239e-25	107.0	2CAFG@1|root,32ZDZ@2|Bacteria,2I800@201174|Actinobacteria,4EKB0@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF3039)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3039
CMS3_k127_7117356_12	1146883.BLASA_1767	1.125e-28	124.0	2DRPS@1|root,33CHR@2|Bacteria,2GXSD@201174|Actinobacteria,4EX0H@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7117356_20	591158.SSMG_06420	7.199e-10	64.0	COG1396@1|root,COG1396@2|Bacteria,2IMPS@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS3_k127_7117356_4	471853.Bcav_4211	7.849e-62	221.0	COG2411@1|root,COG2411@2|Bacteria,2IN3A@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7117356_17	394221.Mmar10_1569	1.281e-19	93.0	COG2852@1|root,COG2852@2|Bacteria,1N0QU@1224|Proteobacteria,2UFZ7@28211|Alphaproteobacteria,4404S@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
CMS3_k127_7117356_22	1206733.BAGC01000110_gene6635	2.144e-05	51.0	2BKTU@1|root,32FA2@2|Bacteria,2HZ4Z@201174|Actinobacteria,4G4ZQ@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7117356_18	67356.KL575690_gene177	8.934e-14	78.0	2C57P@1|root,2ZME3@2|Bacteria,2GZDG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7117356_11	103733.JNYO01000028_gene9040	8.599e-30	122.0	COG0346@1|root,COG0346@2|Bacteria,2IQJB@201174|Actinobacteria,4E611@85010|Pseudonocardiales	201174|Actinobacteria	E	glyoxalase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_7117356_14	1385519.N801_17210	1.997e-23	113.0	2EVIQ@1|root,33NYW@2|Bacteria,2IIIZ@201174|Actinobacteria	201174|Actinobacteria	S	Ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase
CMS3_k127_7125914_4	383372.Rcas_2920	5.434e-42	163.0	COG0106@1|root,COG0106@2|Bacteria,2G6EC@200795|Chloroflexi,376JE@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CMS3_k127_7125914_6	1380387.JADM01000043_gene4174	1.265e-16	91.0	COG4932@1|root,COG4932@2|Bacteria,1QVU9@1224|Proteobacteria,1T2J1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD,REJ
CMS3_k127_7125914_8	1122225.AULQ01000001_gene1899	0.0009311	51.0	2DTJ7@1|root,33KM8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7125914_5	926550.CLDAP_25210	4.068e-41	158.0	COG2335@1|root,COG2335@2|Bacteria,2G7AJ@200795|Chloroflexi	200795|Chloroflexi	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
CMS3_k127_7125914_2	1448860.BBJO01000030_gene319	5.284e-85	307.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,23SA6@183963|Halobacteria	183963|Halobacteria	O	COG0464 ATPases of the AAA class	cdc48b	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
CMS3_k127_7125914_1	1229780.BN381_140046	2.246e-131	440.0	COG0322@1|root,COG2176@1|root,COG0322@2|Bacteria,COG2176@2|Bacteria,2GMC0@201174|Actinobacteria,3UWMB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	GIY-YIG type nucleases (URI domain)	dnaQ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
CMS3_k127_7125914_7	526225.Gobs_0728	1.176e-06	56.0	COG3631@1|root,COG3631@2|Bacteria,2GRE5@201174|Actinobacteria,4EW7K@85013|Frankiales	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
CMS3_k127_7125914_0	1120949.KB903315_gene251	1.074e-133	465.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4D9Z5@85008|Micromonosporales	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
CMS3_k127_7125914_3	504728.K649_05080	2.885e-50	196.0	COG0566@1|root,COG0566@2|Bacteria,1WJ5I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind,TSNR_N
CMS3_k127_7126025_7	1229780.BN381_290055	5.363e-05	55.0	COG4188@1|root,COG4188@2|Bacteria,2GZAJ@201174|Actinobacteria	201174|Actinobacteria	S	Platelet-activating factor acetylhydrolase, isoform II	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
CMS3_k127_7126025_2	1463845.JOIG01000006_gene905	3.765e-70	248.0	COG0457@1|root,COG0457@2|Bacteria,2GJED@201174|Actinobacteria	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7126025_0	1122138.AQUZ01000023_gene7874	6.344e-155	502.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_7126025_4	1122138.AQUZ01000023_gene7873	3.931e-44	164.0	COG3795@1|root,COG3795@2|Bacteria,2GQ62@201174|Actinobacteria	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
CMS3_k127_7126025_6	1313172.YM304_34510	1.363e-21	100.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
CMS3_k127_7126025_1	1382306.JNIM01000001_gene587	4.596e-129	424.0	COG1237@1|root,COG1237@2|Bacteria,2G73K@200795|Chloroflexi	200795|Chloroflexi	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
CMS3_k127_7126025_5	1713.JOFV01000004_gene3311	3.238e-29	119.0	2EG8Z@1|root,332XF@2|Bacteria,2GTHG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7126025_3	748247.AZKH_0523	3.346e-59	212.0	COG2128@1|root,COG2128@2|Bacteria,1RBG0@1224|Proteobacteria,2VKY2@28216|Betaproteobacteria,2KWHV@206389|Rhodocyclales	206389|Rhodocyclales	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_7146258_3	196162.Noca_1615	0.000369	46.0	COG4974@1|root,COG4974@2|Bacteria,2I5BM@201174|Actinobacteria	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
CMS3_k127_7146258_1	263358.VAB18032_04595	1.995e-93	312.0	COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,4DBWJ@85008|Micromonosporales	201174|Actinobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,UPF0114
CMS3_k127_7146258_0	1120950.KB892723_gene1935	2.251e-152	493.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4DNKP@85009|Propionibacteriales	201174|Actinobacteria	L	Transposase, Mutator family	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
CMS3_k127_7146258_2	28444.JODQ01000006_gene555	1.181e-06	53.0	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria,4EG08@85012|Streptosporangiales	201174|Actinobacteria	M	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,HTH_31,Trans_reg_C,WD40
CMS3_k127_7148676_4	710111.FraQA3DRAFT_0116	3.866e-85	289.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran
CMS3_k127_7148676_3	644283.Micau_5085	3.182e-89	302.0	COG1173@1|root,COG1173@2|Bacteria,2GNQ5@201174|Actinobacteria,4DIE1@85008|Micromonosporales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	oppC4	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS3_k127_7148676_1	1122939.ATUD01000016_gene1861	3.591e-102	341.0	COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4CSMS@84995|Rubrobacteria	84995|Rubrobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS3_k127_7148676_2	649638.Trad_2584	9.404e-92	308.0	COG1028@1|root,COG1028@2|Bacteria,1WIMS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_7148676_5	693977.Deipr_0148	9.843e-58	220.0	COG3191@1|root,COG3191@2|Bacteria,1WJKZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EQ	PFAM peptidase S58 DmpA	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
CMS3_k127_7148676_6	1048834.TC41_2569	1.5e-55	204.0	COG0483@1|root,COG0483@2|Bacteria,1UKWB@1239|Firmicutes,4ITKN@91061|Bacilli	91061|Bacilli	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
CMS3_k127_7148676_0	518766.Rmar_1856	3.574e-252	790.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria	2|Bacteria	P	Belongs to the sulfate adenylyltransferase family	cysC	GO:0000096,GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0004779,GO:0004781,GO:0006082,GO:0006520,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010134,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019379,GO:0019419,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0070566,GO:0071704,GO:1901564	1.8.4.10,1.8.4.8,2.7.1.25,2.7.7.4	ko:K00390,ko:K00860,ko:K00958,ko:K13811	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R02021,R04928,R04929	RC00002,RC00007,RC00078,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
CMS3_k127_7148676_7	593907.Celgi_1112	4.235e-37	154.0	COG2385@1|root,COG2385@2|Bacteria,2IEPH@201174|Actinobacteria,4F2HG@85016|Cellulomonadaceae	201174|Actinobacteria	D	SpoIID LytB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LGFP,SpoIID
CMS3_k127_7180400_25	455632.SGR_4321	1.038e-70	249.0	COG0310@1|root,COG0310@2|Bacteria,2GK2U@201174|Actinobacteria,417FU@629295|Streptomyces griseus group	201174|Actinobacteria	P	PDGLE domain	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
CMS3_k127_7180400_46	290397.Adeh_1564	9.805e-21	97.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42MN8@68525|delta/epsilon subdivisions,2WQKR@28221|Deltaproteobacteria,2YVE5@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS3_k127_7180400_11	631362.Thi970DRAFT_04267	9.953e-133	438.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales	135613|Chromatiales	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_7180400_45	369723.Strop_3506	1.703e-21	98.0	COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,2GMG7@201174|Actinobacteria,4DDUD@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR,MerR_1
CMS3_k127_7180400_28	391037.Sare_4810	6.188e-66	231.0	COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,2GMG7@201174|Actinobacteria,4DDUD@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR,MerR_1
CMS3_k127_7180400_6	1313172.YM304_01440	3.027e-155	498.0	COG2070@1|root,COG2070@2|Bacteria,2GKGT@201174|Actinobacteria	201174|Actinobacteria	S	2-nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
CMS3_k127_7180400_1	1313172.YM304_22380	1.771e-267	839.0	COG3185@1|root,COG3185@2|Bacteria,2GJNC@201174|Actinobacteria,4CNFT@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Pfam:DUF1446	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
CMS3_k127_7180400_2	1313172.YM304_22370	8.876e-263	825.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4CNKR@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Pfam:CPSase_L_chain	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
CMS3_k127_7180400_0	1313172.YM304_22360	2.316e-283	877.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CNMV@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
CMS3_k127_7180400_20	1211815.CBYP010000063_gene1909	6.213e-91	306.0	28HG7@1|root,2Z7S3@2|Bacteria,2GMJK@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Wyosine base formation	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N,Wyosine_form
CMS3_k127_7180400_24	298654.FraEuI1c_2880	1.558e-77	269.0	COG1024@1|root,COG1024@2|Bacteria,2GJ0N@201174|Actinobacteria,4ESJA@85013|Frankiales	201174|Actinobacteria	I	Enoyl-CoA hydratase	-	-	4.2.1.17,4.2.1.18	ko:K01692,ko:K13766	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00036,M00087	R02085,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_7180400_8	1197906.CAJQ02000023_gene2282	6.245e-150	487.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR15@28211|Alphaproteobacteria,3JSPS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	MA20_22980	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_7180400_35	1313172.YM304_22350	2.993e-47	177.0	COG1309@1|root,COG1309@2|Bacteria,2ID86@201174|Actinobacteria	201174|Actinobacteria	K	TetR Family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7180400_32	1120797.KB908255_gene700	1.1e-55	200.0	COG3651@1|root,COG3651@2|Bacteria,2IHNI@201174|Actinobacteria,2396K@1762|Mycobacteriaceae	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
CMS3_k127_7180400_41	552811.Dehly_1481	5.609e-27	117.0	COG3945@1|root,COG3945@2|Bacteria	2|Bacteria	P	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
CMS3_k127_7180400_34	1227487.C474_16639	1.636e-47	188.0	COG0683@1|root,arCOG01020@2157|Archaea,2XUWA@28890|Euryarchaeota,23TUR@183963|Halobacteria	183963|Halobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
CMS3_k127_7180400_31	1254432.SCE1572_20260	1.099e-60	218.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,42QV6@68525|delta/epsilon subdivisions,2WMN1@28221|Deltaproteobacteria,2Z08T@29|Myxococcales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
CMS3_k127_7180400_27	1265505.ATUG01000002_gene1745	7.846e-67	234.0	COG0410@1|root,COG0410@2|Bacteria,1PEAZ@1224|Proteobacteria,42YA8@68525|delta/epsilon subdivisions,2X2AX@28221|Deltaproteobacteria,2MNBB@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
CMS3_k127_7180400_44	1001240.GY21_11175	1.214e-23	113.0	COG0559@1|root,COG0559@2|Bacteria,2GKAR@201174|Actinobacteria,4FPHI@85023|Microbacteriaceae	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	urtB	-	-	ko:K11960	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
CMS3_k127_7180400_38	1202768.JROF01000013_gene870	8.844e-42	169.0	COG4177@1|root,arCOG01274@2157|Archaea,2XWFD@28890|Euryarchaeota,23SM0@183963|Halobacteria	183963|Halobacteria	E	COG4177 ABC-type branched-chain amino acid transport system, permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
CMS3_k127_7180400_7	1380390.JIAT01000010_gene3414	2.606e-153	501.0	COG0365@1|root,COG0365@2|Bacteria,2GJVK@201174|Actinobacteria,4CRKB@84995|Rubrobacteria	84995|Rubrobacteria	I	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_7180400_4	113395.AXAI01000007_gene1373	2.868e-226	713.0	COG1024@1|root,COG1024@2|Bacteria,1N817@1224|Proteobacteria,2TQTE@28211|Alphaproteobacteria,3JTG3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	boxC	-	4.1.2.44	ko:K15513	ko00362,map00362	-	R09556	RC03426	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS3_k127_7180400_3	114615.BRADO6788	1.382e-234	739.0	COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2TTIG@28211|Alphaproteobacteria,3JSI1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	benzoyl-CoA oxygenase	boxB	-	1.14.13.208	ko:K15512	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	-
CMS3_k127_7180400_39	266117.Rxyl_1747	4.665e-31	132.0	COG1309@1|root,COG1309@2|Bacteria,2HRRV@201174|Actinobacteria,4CTUM@84995|Rubrobacteria	84995|Rubrobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
CMS3_k127_7180400_17	526227.Mesil_2458	6.267e-104	350.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1WMSA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Diguanylate cyclase with GAF sensor	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF
CMS3_k127_7180400_48	1038862.KB893860_gene2623	1.356e-17	92.0	COG1361@1|root,COG1361@2|Bacteria,1P1RW@1224|Proteobacteria,2UV6I@28211|Alphaproteobacteria,3K4M6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7180400_53	886377.Murru_3025	0.0005817	44.0	COG1361@1|root,COG1361@2|Bacteria,4NMB8@976|Bacteroidetes,1I065@117743|Flavobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CHU_C,Calx-beta,DUF11,SdrD_B
CMS3_k127_7180400_18	1123290.AUDQ01000006_gene1800	6.84e-98	349.0	COG2366@1|root,COG2366@2|Bacteria,1UFHA@1239|Firmicutes,4HACM@91061|Bacilli,26EP7@186818|Planococcaceae	91061|Bacilli	S	Penicillin acylase	-	-	-	-	-	-	-	-	-	-	-	-	Penicil_amidase
CMS3_k127_7180400_52	479432.Sros_8401	4.603e-05	54.0	COG3147@1|root,COG3147@2|Bacteria,2ID4R@201174|Actinobacteria,4EHHH@85012|Streptosporangiales	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7180400_43	330214.NIDE3836	1.154e-24	112.0	COG2197@1|root,COG3290@1|root,COG2197@2|Bacteria,COG3290@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	prhJ	-	-	ko:K06375	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	GerE,HATPase_c,PAS,PAS_4,PAS_8,PAS_9,Response_reg
CMS3_k127_7180400_36	1521187.JPIM01000039_gene487	1.65e-43	171.0	COG0596@1|root,COG0596@2|Bacteria,2G6VQ@200795|Chloroflexi,377CS@32061|Chloroflexia	32061|Chloroflexia	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CMS3_k127_7180400_37	573064.Mefer_0041	3.969e-43	162.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,23QQ2@183939|Methanococci	183939|Methanococci	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	GO:0003674,GO:0003824,GO:0003861,GO:0016829,GO:0016835,GO:0016836	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
CMS3_k127_7180400_12	429009.Adeg_1100	2.755e-129	426.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,42FQ2@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
CMS3_k127_7180400_22	767817.Desgi_0644	1.895e-81	277.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,260VS@186807|Peptococcaceae	186801|Clostridia	IQ	PFAM short chain dehydrogenase	-	-	1.1.1.100	ko:K00059,ko:K07535	ko00061,ko00333,ko00362,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,ko01220,map00061,map00333,map00362,map00780,map01040,map01100,map01120,map01130,map01212,map01220	M00083,M00540,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05582,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117,RC00154	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_7180400_30	1125863.JAFN01000001_gene160	1.473e-62	224.0	COG1024@1|root,COG1024@2|Bacteria,1MW41@1224|Proteobacteria,42N51@68525|delta/epsilon subdivisions,2WKBV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_7180400_15	1245471.PCA10_26520	4.367e-109	368.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
CMS3_k127_7180400_40	1068980.ARVW01000001_gene4154	3.024e-29	126.0	COG1309@1|root,COG1309@2|Bacteria,2GMNZ@201174|Actinobacteria,4E3N6@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_7180400_42	1121422.AUMW01000022_gene1605	6.293e-27	125.0	COG1014@1|root,COG1014@2|Bacteria,1V3RG@1239|Firmicutes,24I3Y@186801|Clostridia,26231@186807|Peptococcaceae	186801|Clostridia	C	PFAM Pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
CMS3_k127_7180400_21	443144.GM21_1328	1.322e-82	289.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2WJQ0@28221|Deltaproteobacteria,43SWR@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM thiamine pyrophosphate	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
CMS3_k127_7180400_10	1121468.AUBR01000007_gene242	4.294e-142	468.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,42FG2@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
CMS3_k127_7180400_26	316055.RPE_0985	1.951e-68	243.0	COG1014@1|root,COG1146@1|root,COG1014@2|Bacteria,COG1146@2|Bacteria,1RH9B@1224|Proteobacteria,2U5CY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR
CMS3_k127_7180400_5	316056.RPC_0693	3.361e-214	681.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,3JRVJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4_10,POR_N,TPP_enzyme_C
CMS3_k127_7180400_13	1192034.CAP_5366	2.172e-123	408.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2YTZB@29|Myxococcales	28221|Deltaproteobacteria	E	synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
CMS3_k127_7180400_47	1114856.C496_19835	8.694e-20	95.0	COG1545@1|root,arCOG01285@2157|Archaea	2157|Archaea	I	nucleic-acid-binding protein containing a Zn-ribbon	acaC	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
CMS3_k127_7180400_16	1343740.M271_50210	8.357e-106	359.0	COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_7180400_19	1232443.BAIA02000043_gene2288	5.848e-96	332.0	COG2828@1|root,COG2828@2|Bacteria,1TPP6@1239|Firmicutes,24E0P@186801|Clostridia,26A56@186813|unclassified Clostridiales	186801|Clostridia	S	PrpF protein	-	-	5.3.3.6	ko:K20451	ko00760,ko01120,map00760,map01120	-	R03070	RC00844	ko00000,ko00001,ko01000	-	-	-	PrpF
CMS3_k127_7180400_14	1232410.KI421412_gene166	1.032e-114	382.0	COG1064@1|root,COG1064@2|Bacteria,1QVIH@1224|Proteobacteria,42NMX@68525|delta/epsilon subdivisions,2WJGB@28221|Deltaproteobacteria,43TA2@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Alanine dehydrogenase/PNT, C-terminal domain	bamQ	-	1.1.1.368	ko:K07538	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05581	RC00850	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_7180400_9	1187851.A33M_3194	3.257e-148	477.0	COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,2U4PY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	3.7.1.21	ko:K07539	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05593,R05594,R10696	RC01430,RC01431,RC03237	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_7180400_33	706587.Desti_1480	1.67e-49	192.0	COG1024@1|root,COG1024@2|Bacteria,1R8QP@1224|Proteobacteria,42S3Y@68525|delta/epsilon subdivisions,2WNXJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	bamR	-	4.2.1.100	ko:K07537	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05597	RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_7180400_50	1206733.BAGC01000114_gene7147	1.437e-15	80.0	2ASXR@1|root,31IDA@2|Bacteria,2GWS7@201174|Actinobacteria,4G579@85025|Nocardiaceae	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
CMS3_k127_7180400_23	1382306.JNIM01000001_gene2431	7.666e-81	278.0	COG2084@1|root,COG2084@2|Bacteria,2G8RG@200795|Chloroflexi	200795|Chloroflexi	C	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
CMS3_k127_7180400_51	797299.HALLA_00370	2.402e-07	60.0	COG0662@1|root,arCOG03003@2157|Archaea,2XX6B@28890|Euryarchaeota,23WEI@183963|Halobacteria	183963|Halobacteria	G	COG2140 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_7180400_49	279238.Saro_3689	6.564e-16	87.0	COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2TUWC@28211|Alphaproteobacteria,2K2PP@204457|Sphingomonadales	204457|Sphingomonadales	Q	2-keto-4-pentenoate hydratase	-	-	4.2.1.132,4.2.1.80	ko:K18364	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R02601,R05864	RC00750,RC02676	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
CMS3_k127_7180400_29	502025.Hoch_5114	2.022e-65	230.0	28XBK@1|root,2ZJ9G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7209369_2	526226.Gbro_2828	2.616e-46	173.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4GC2R@85026|Gordoniaceae	201174|Actinobacteria	J	FtsJ-like methyltransferase	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
CMS3_k127_7209369_3	1121946.AUAX01000036_gene1901	4.562e-45	172.0	COG0705@1|root,COG0705@2|Bacteria,2GNPK@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Rhomboid family protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS3_k127_7209369_4	351607.Acel_1250	3.728e-39	156.0	COG0647@1|root,COG0647@2|Bacteria,2GK7V@201174|Actinobacteria,4ESEC@85013|Frankiales	201174|Actinobacteria	G	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
CMS3_k127_7209369_1	631454.N177_1671	5.939e-81	280.0	COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,2TSR9@28211|Alphaproteobacteria,1JNZW@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
CMS3_k127_7209369_5	1238182.C882_3002	2.11e-14	79.0	COG0748@1|root,COG0748@2|Bacteria,1RFVC@1224|Proteobacteria,2TV14@28211|Alphaproteobacteria,2JS7X@204441|Rhodospirillales	204441|Rhodospirillales	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07226	-	-	-	-	ko00000	-	-	-	DUF2470,Putative_PNPOx,Pyrid_oxidase_2
CMS3_k127_7209369_0	1392838.AWNM01000027_gene4532	3.923e-96	325.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2VIJP@28216|Betaproteobacteria,3T2X7@506|Alcaligenaceae	28216|Betaproteobacteria	E	Belongs to the peptidase M20A family. ArgE subfamily	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_723014_3	935866.JAER01000002_gene1899	9.565e-33	130.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4DN4X@85009|Propionibacteriales	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
CMS3_k127_723014_4	1229204.AMYY01000006_gene1089	1.064e-22	104.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,2TRRN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
CMS3_k127_723014_1	67332.FM21_08385	6.129e-85	290.0	COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria	201174|Actinobacteria	S	Displays ATPase and GTPase activities	yvcJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
CMS3_k127_723014_2	702437.HMPREF9432_01624	2.848e-63	232.0	COG0391@1|root,COG0391@2|Bacteria,1TPNV@1239|Firmicutes,4H2S9@909932|Negativicutes	909932|Negativicutes	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
CMS3_k127_723014_0	452652.KSE_55400	7.111e-135	437.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,2M14Z@2063|Kitasatospora	201174|Actinobacteria	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
CMS3_k127_723014_5	368407.Memar_0928	4.011e-09	59.0	COG0126@1|root,arCOG00496@2157|Archaea	2157|Archaea	F	Belongs to the phosphoglycerate kinase family	pgk	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
CMS3_k127_7235946_1	1229781.C272_07207	1.696e-72	252.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4F9BH@85019|Brevibacteriaceae	201174|Actinobacteria	GM	ATPases associated with a variety of cellular activities	tagH	-	3.6.3.40	ko:K09693	ko02010,map02010	M00251	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.104	-	-	ABC_tran
CMS3_k127_7235946_3	661478.OP10G_0950	2.007e-19	104.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
CMS3_k127_7235946_0	1254432.SCE1572_09945	6.488e-95	337.0	COG5555@1|root,COG5555@2|Bacteria,1QX82@1224|Proteobacteria,43CYG@68525|delta/epsilon subdivisions,2X86M@28221|Deltaproteobacteria,2Z3M6@29|Myxococcales	28221|Deltaproteobacteria	N	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP
CMS3_k127_7235946_2	247156.NFA_9200	2.911e-51	186.0	COG0219@1|root,COG0219@2|Bacteria,2IHN9@201174|Actinobacteria,4G0KA@85025|Nocardiaceae	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	spoU	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
CMS3_k127_7235946_4	754027.HMPREF9554_02481	1.942e-13	80.0	COG0824@1|root,COG0824@2|Bacteria,2J837@203691|Spirochaetes	203691|Spirochaetes	S	acyl-CoA thioester hydrolase, YbgC YbaW family	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
CMS3_k127_7254404_4	398527.Bphyt_4253	1.907e-16	83.0	COG0391@1|root,COG0391@2|Bacteria,1NK78@1224|Proteobacteria,2VMUY@28216|Betaproteobacteria,1K5SP@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Uncharacterised protein family UPF0052	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
CMS3_k127_7254404_3	525904.Tter_1862	1.455e-61	220.0	COG1478@1|root,COG1478@2|Bacteria,2NQRM@2323|unclassified Bacteria	2|Bacteria	S	F420-0:Gamma-glutamyl ligase	fbiB	GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase,Nitroreductase
CMS3_k127_7254404_2	452637.Oter_1629	1.986e-105	351.0	COG0266@1|root,COG0266@2|Bacteria	2|Bacteria	L	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
CMS3_k127_7254404_0	4006.Lus10041823	3.116e-141	463.0	COG1089@1|root,KOG1372@2759|Eukaryota,37HE5@33090|Viridiplantae,3G75T@35493|Streptophyta,4JRKX@91835|fabids	35493|Streptophyta	G	GDP-mannose 4,6 dehydratase	-	GO:0000902,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0008446,GO:0009058,GO:0009225,GO:0009226,GO:0009653,GO:0009826,GO:0009987,GO:0016043,GO:0016049,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0032502,GO:0032989,GO:0034641,GO:0034654,GO:0040007,GO:0042350,GO:0042351,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046368,GO:0046483,GO:0048589,GO:0048856,GO:0048869,GO:0055086,GO:0060560,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
CMS3_k127_7254404_1	671143.DAMO_0912	1.322e-128	419.0	COG0451@1|root,COG0451@2|Bacteria,2NPS7@2323|unclassified Bacteria	2|Bacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
CMS3_k127_7261274_1	1265313.HRUBRA_02705	4.898e-26	111.0	COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,1S4VY@1236|Gammaproteobacteria,1JAMV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7261274_0	1121935.AQXX01000042_gene4588	2.345e-28	130.0	COG4733@1|root,COG4733@2|Bacteria,1R55I@1224|Proteobacteria,1S5X2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7261274_2	1123367.C666_16985	1.705e-18	88.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VJ9G@28216|Betaproteobacteria,2KV5H@206389|Rhodocyclales	206389|Rhodocyclales	O	Belongs to the peptidase S1C family	-	-	-	ko:K04691,ko:K04772	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_7302203_3	469371.Tbis_2990	3.484e-72	255.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,4E10U@85010|Pseudonocardiales	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
CMS3_k127_7302203_7	1223544.GSI01S_24_00030	4.04e-34	147.0	COG4585@1|root,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4GC9N@85026|Gordoniaceae	201174|Actinobacteria	T	PspC domain	tcsS3	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,PspC
CMS3_k127_7302203_6	1869.MB27_02930	2.112e-43	169.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4D9AV@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	tcsR3	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_7302203_5	1304876.AZVC01000011_gene3757	9.557e-59	217.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria,1W81P@1268|Micrococcaceae	201174|Actinobacteria	L	DNA polymerase Ligase (LigD)	ligD	GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
CMS3_k127_7302203_8	502025.Hoch_5724	1.029e-32	134.0	COG1610@1|root,COG1610@2|Bacteria,1PS1I@1224|Proteobacteria,43A7B@68525|delta/epsilon subdivisions,2X2EM@28221|Deltaproteobacteria,2Z2BW@29|Myxococcales	28221|Deltaproteobacteria	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
CMS3_k127_7302203_9	1229780.BN381_310068	6.11e-29	119.0	2DMIE@1|root,32RSG@2|Bacteria,2IQCG@201174|Actinobacteria,3UWR8@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB	GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
CMS3_k127_7302203_14	1961.JOAK01000021_gene7159	9.446e-10	68.0	2F5KP@1|root,33Y5V@2|Bacteria,2GP4A@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SMI1_KNR4
CMS3_k127_7302203_1	1229780.BN381_310061	4.285e-125	410.0	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,3UWC1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0008150,GO:0040007	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
CMS3_k127_7302203_10	1121877.JQKF01000016_gene162	4.73e-26	117.0	COG2345@1|root,COG2345@2|Bacteria,2HGTI@201174|Actinobacteria,4CNV8@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
CMS3_k127_7302203_13	1089550.ATTH01000002_gene47	4.632e-14	76.0	COG2128@1|root,COG2128@2|Bacteria,4NN22@976|Bacteroidetes,1FK4T@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	PA26 p53-induced protein (sestrin)	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_7302203_12	1342299.Z947_3314	1.733e-14	76.0	COG2128@1|root,COG2128@2|Bacteria,1PQ1G@1224|Proteobacteria,2U17A@28211|Alphaproteobacteria,3ZX1D@60136|Sulfitobacter	28211|Alphaproteobacteria	S	Alkylhydroperoxidase AhpD family core domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_7302203_2	1123242.JH636435_gene2759	5.893e-107	360.0	COG2355@1|root,COG2355@2|Bacteria,2IXYG@203682|Planctomycetes	203682|Planctomycetes	E	PFAM peptidase M19 renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
CMS3_k127_7302203_0	344747.PM8797T_17839	0.0	1177.0	COG1048@1|root,COG1048@2|Bacteria,2IY29@203682|Planctomycetes	203682|Planctomycetes	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
CMS3_k127_7302203_4	1157490.EL26_00610	1.447e-69	241.0	COG2041@1|root,COG2041@2|Bacteria,1V1P9@1239|Firmicutes,4HFQC@91061|Bacilli,278B0@186823|Alicyclobacillaceae	91061|Bacilli	S	Oxidoreductase molybdopterin binding domain	yuiH	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
CMS3_k127_7302203_11	357808.RoseRS_0325	6.551e-20	97.0	COG0526@1|root,COG0526@2|Bacteria,2G72F@200795|Chloroflexi,377HE@32061|Chloroflexia	32061|Chloroflexia	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_7303573_3	1317118.ATO8_09498	3.203e-09	65.0	COG2267@1|root,COG2267@2|Bacteria,1QUPE@1224|Proteobacteria,2TT7G@28211|Alphaproteobacteria,4KK3S@93682|Roseivivax	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	bchO	-	-	ko:K06049	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_7303573_0	1380393.JHVP01000003_gene1188	1.286e-134	440.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4EUKK@85013|Frankiales	201174|Actinobacteria	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_7303573_1	525909.Afer_1269	1.999e-71	256.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4CP58@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
CMS3_k127_7303573_5	1442599.JAAN01000012_gene118	5.734e-07	61.0	COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,1RP39@1236|Gammaproteobacteria,1X3HY@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Permeases of the major facilitator superfamily	ycaD	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
CMS3_k127_7303573_4	1131462.DCF50_p435	5.855e-09	65.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24BRX@186801|Clostridia,260H8@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
CMS3_k127_7303573_2	649638.Trad_0252	1.754e-10	65.0	COG0365@1|root,COG0365@2|Bacteria,1WI8W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
CMS3_k127_7306238_0	1312959.KI914652_gene478	6.095e-67	239.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_7307433_5	1379270.AUXF01000006_gene165	3.452e-14	75.0	COG0134@1|root,COG0134@2|Bacteria,1ZTMA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Indole-3-glycerol phosphate synthase	-	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
CMS3_k127_7307433_7	1462527.CCDM010000002_gene1698	0.0009028	47.0	COG2010@1|root,COG2010@2|Bacteria,1VA0V@1239|Firmicutes,4HKF3@91061|Bacilli,23KU4@182709|Oceanobacillus	91061|Bacilli	C	Cytochrome c	cccA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K13300	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
CMS3_k127_7307433_2	1172188.KB911822_gene963	8.592e-59	222.0	COG5002@1|root,COG5002@2|Bacteria,2GMH4@201174|Actinobacteria,4FIT2@85021|Intrasporangiaceae	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	baeS	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_7307433_1	138119.DSY4391	2.868e-66	236.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,2643U@186807|Peptococcaceae	186801|Clostridia	K	PFAM response regulator receiver	-	-	-	ko:K07668	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_7307433_4	401053.AciPR4_0709	6.671e-19	99.0	COG0354@1|root,COG0354@2|Bacteria,3Y2PI@57723|Acidobacteria,2JJ3H@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
CMS3_k127_7307433_0	1449976.KALB_7044	1.657e-138	456.0	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4DYDE@85010|Pseudonocardiales	201174|Actinobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
CMS3_k127_7307433_3	1121877.JQKF01000002_gene1731	4.664e-47	179.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria,4CNHE@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
CMS3_k127_7307433_6	1463921.JODF01000016_gene6936	1.498e-05	54.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
CMS3_k127_7320480_1	1043493.BBLU01000017_gene1365	1.506e-121	399.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the aspartokinase family	ask	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
CMS3_k127_7320480_3	292459.STH2625	3.224e-46	176.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,247XN@186801|Clostridia	186801|Clostridia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppi	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Cu_amine_oxidN1,Pro_isomerase
CMS3_k127_7320480_2	1123371.ATXH01000003_gene1914	1.697e-62	225.0	COG0613@1|root,COG0613@2|Bacteria,2GGVB@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
CMS3_k127_7320480_5	258533.BN977_04094	2.92e-36	153.0	COG0642@1|root,COG1716@1|root,COG1716@2|Bacteria,COG2205@2|Bacteria,2GK5I@201174|Actinobacteria,23869@1762|Mycobacteriaceae	201174|Actinobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	DZR,FHA,zinc_ribbon_2
CMS3_k127_7320480_7	1158602.I590_01097	2.135e-05	48.0	COG1226@1|root,COG1226@2|Bacteria,1UP09@1239|Firmicutes,4IUWN@91061|Bacilli,4B6PU@81852|Enterococcaceae	91061|Bacilli	P	Ion transport protein	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
CMS3_k127_7320480_4	1283299.AUKG01000001_gene1898	5.592e-39	151.0	COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,4CQ97@84995|Rubrobacteria	84995|Rubrobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
CMS3_k127_7320480_0	1146883.BLASA_0208	3.715e-124	415.0	COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,4EU3Z@85013|Frankiales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
CMS3_k127_7320480_6	326427.Cagg_2466	2.326e-06	51.0	COG0183@1|root,COG0183@2|Bacteria,2G66E@200795|Chloroflexi,3753E@32061|Chloroflexia	32061|Chloroflexia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_7372763_8	926564.KI911649_gene1793	1.283e-68	242.0	COG0557@1|root,COG0557@2|Bacteria,2GNSM@201174|Actinobacteria,4F3GI@85017|Promicromonosporaceae	201174|Actinobacteria	K	RNB	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
CMS3_k127_7372763_13	469383.Cwoe_0932	3.625e-21	96.0	COG2337@1|root,COG2337@2|Bacteria	2|Bacteria	T	Toxic component of a toxin-antitoxin (TA) module	mazF5	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
CMS3_k127_7372763_10	215803.DB30_0685	5.589e-39	149.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
CMS3_k127_7372763_15	1172188.KB911824_gene3471	1.551e-08	71.0	COG2374@1|root,COG2374@2|Bacteria,2I2E0@201174|Actinobacteria,4FFZJ@85021|Intrasporangiaceae	201174|Actinobacteria	M	Lamin Tail Domain	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Big_3_5,Big_5,CW_binding_2,DUF3616,Exo_endo_phos,LTD
CMS3_k127_7372763_1	68170.KL590499_gene4927	1.299e-203	717.0	COG2931@1|root,COG2931@2|Bacteria,2GR03@201174|Actinobacteria,4E8ZQ@85010|Pseudonocardiales	201174|Actinobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,HemolysinCabind,Peptidase_M91,fn3
CMS3_k127_7372763_14	443218.AS9A_2782	4.767e-14	79.0	2DZHZ@1|root,31ZDG@2|Bacteria,2IN6I@201174|Actinobacteria,23A9W@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7372763_0	1122222.AXWR01000003_gene1381	0.0	1240.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1WI44@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
CMS3_k127_7372763_9	2074.JNYD01000022_gene1416	5.89e-50	187.0	COG0500@1|root,COG0500@2|Bacteria,2I3S9@201174|Actinobacteria,4EF8J@85010|Pseudonocardiales	201174|Actinobacteria	Q	Ribosomal RNA adenine dimethylase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_7372763_6	1306174.JODP01000005_gene1403	2.092e-84	297.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_7372763_4	1174684.EBMC1_07035	6e-121	405.0	COG0154@1|root,COG0154@2|Bacteria,1MWWQ@1224|Proteobacteria,2TSN9@28211|Alphaproteobacteria,2K183@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
CMS3_k127_7372763_3	1117943.SFHH103_02949	8.926e-132	436.0	COG1679@1|root,COG1679@2|Bacteria,1NFH4@1224|Proteobacteria,2TTR6@28211|Alphaproteobacteria,4BJD8@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
CMS3_k127_7372763_12	1117943.SFHH103_02948	1.187e-28	119.0	COG1786@1|root,COG1786@2|Bacteria,1N5DN@1224|Proteobacteria,2UGA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
CMS3_k127_7372763_5	1206741.BAFX01000113_gene7289	2.329e-114	376.0	COG0053@1|root,COG0053@2|Bacteria,2GKSG@201174|Actinobacteria,4FUEZ@85025|Nocardiaceae	201174|Actinobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
CMS3_k127_7372763_2	1123261.AXDW01000003_gene2011	7.695e-181	587.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria,1X4B6@135614|Xanthomonadales	135614|Xanthomonadales	O	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M13,Peptidase_M13_N
CMS3_k127_7372763_11	1146883.BLASA_1347	3.527e-35	151.0	2DXTJ@1|root,346GW@2|Bacteria,2H9GA@201174|Actinobacteria	201174|Actinobacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7372763_7	1440774.Y900_006330	4.436e-76	264.0	COG2267@1|root,COG2267@2|Bacteria,2I4BW@201174|Actinobacteria,236TM@1762|Mycobacteriaceae	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_7397512_3	926550.CLDAP_13750	3.741e-145	481.0	COG1404@1|root,COG1404@2|Bacteria,2G7GP@200795|Chloroflexi	200795|Chloroflexi	M	LPXTG-motif cell wall anchor domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
CMS3_k127_7397512_1	502025.Hoch_6605	2.117e-202	645.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria,2YX9H@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase beta thumb	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
CMS3_k127_7397512_10	1457250.BBMO01000001_gene1756	3.824e-18	91.0	COG3402@1|root,arCOG04622@2157|Archaea,2XXVX@28890|Euryarchaeota,23W3G@183963|Halobacteria	183963|Halobacteria	S	Membrane-flanked domain	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
CMS3_k127_7397512_7	268739.Nmlp_2382	3.217e-29	133.0	COG3428@1|root,arCOG04619@2157|Archaea,2XU23@28890|Euryarchaeota,23T8S@183963|Halobacteria	183963|Halobacteria	S	membrane	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
CMS3_k127_7397512_9	192952.MM_1452	3.553e-21	104.0	COG0589@1|root,arCOG00449@2157|Archaea,2Y8D8@28890|Euryarchaeota	28890|Euryarchaeota	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS3_k127_7397512_4	1265505.ATUG01000002_gene1358	1.514e-140	455.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,43060@68525|delta/epsilon subdivisions,2WVAA@28221|Deltaproteobacteria,2MNEB@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS3_k127_7397512_5	110319.CF8_0231	2.321e-113	381.0	COG3004@1|root,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria,4DNTA@85009|Propionibacteriales	201174|Actinobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1,Thioredoxin_4
CMS3_k127_7397512_8	467661.RKLH11_2185	4.359e-28	123.0	COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,2U6B6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
CMS3_k127_7397512_2	1229780.BN381_640016	5.761e-163	529.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	bglIM	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
CMS3_k127_7397512_6	2045.KR76_25885	5.594e-41	172.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4DN8Z@85009|Propionibacteriales	201174|Actinobacteria	E	Prephenate dehydratase	pheA	-	1.3.1.12,4.2.1.51,5.4.99.5	ko:K04518,ko:K14170,ko:K14187	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715,R01728	RC00125,RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
CMS3_k127_7397512_0	469371.Tbis_2890	3.206e-259	820.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4DYC3@85010|Pseudonocardiales	201174|Actinobacteria	C	Dehydrogenase E1 component	kgd	-	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
CMS3_k127_7435414_0	1304284.L21TH_1542	0.0	1248.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,36E0I@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS3_k127_7435414_1	1429916.X566_04850	1.42e-13	82.0	2CIPC@1|root,2Z9HB@2|Bacteria,1R3W8@1224|Proteobacteria,2TST7@28211|Alphaproteobacteria,3JTHB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
CMS3_k127_7436257_0	756883.Halar_1515	2.922e-25	123.0	COG1033@1|root,arCOG02174@2157|Archaea	2157|Archaea	L	of the RND superfamily	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS3_k127_7437096_2	1229780.BN381_130019	3.291e-104	347.0	COG0046@1|root,COG0046@2|Bacteria,2GKG6@201174|Actinobacteria,3UWF7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
CMS3_k127_7437096_4	697281.Mahau_1635	1.763e-80	275.0	COG0047@1|root,COG0047@2|Bacteria,1TP1B@1239|Firmicutes,24A2E@186801|Clostridia,42EVD@68295|Thermoanaerobacterales	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
CMS3_k127_7437096_10	1528106.JRJE01000009_gene1687	3.698e-13	73.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,2JTEV@204441|Rhodospirillales	204441|Rhodospirillales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
CMS3_k127_7437096_3	1123242.JH636434_gene4773	7.546e-96	323.0	COG0152@1|root,COG0152@2|Bacteria,2IY7D@203682|Planctomycetes	203682|Planctomycetes	F	SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
CMS3_k127_7437096_8	1394178.AWOO02000026_gene5179	2.366e-28	124.0	COG1595@1|root,COG1595@2|Bacteria,2IRNG@201174|Actinobacteria,4EJHC@85012|Streptosporangiales	201174|Actinobacteria	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_7437096_7	861299.J421_0312	1.306e-32	132.0	COG2346@1|root,COG2346@2|Bacteria,1ZTRZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
CMS3_k127_7437096_5	1122247.C731_0954	1.504e-54	206.0	COG3876@1|root,COG3876@2|Bacteria,2GJ19@201174|Actinobacteria,236UN@1762|Mycobacteriaceae	201174|Actinobacteria	S	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
CMS3_k127_7437096_0	997346.HMPREF9374_3070	3.69e-139	460.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,4HACW@91061|Bacilli,27BMB@186824|Thermoactinomycetaceae	91061|Bacilli	F	Adenylosuccinate lyase C-terminus	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS09895	ADSL_C,Lyase_1
CMS3_k127_7437096_6	1105031.HMPREF1141_2115	4.059e-44	165.0	COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,24HCB@186801|Clostridia,36WW8@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
CMS3_k127_7437096_1	411684.HPDFL43_03309	5.501e-111	372.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,43IG4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
CMS3_k127_7437096_9	1338011.BD94_1436	3.866e-19	87.0	COG0104@1|root,COG0104@2|Bacteria,4NGRZ@976|Bacteroidetes,1HWP1@117743|Flavobacteriia,34R16@308865|Elizabethkingia	976|Bacteroidetes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
CMS3_k127_7454214_4	479435.Kfla_2974	3.616e-108	362.0	COG1018@1|root,COG1018@2|Bacteria,2GKGS@201174|Actinobacteria,4DNQQ@85009|Propionibacteriales	201174|Actinobacteria	C	Oxidoreductase FAD-binding domain	paaK	-	-	ko:K02613	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
CMS3_k127_7454214_9	1003200.AXXA_18306	3.404e-44	167.0	COG2151@1|root,COG3677@1|root,COG2151@2|Bacteria,COG3677@2|Bacteria,1RF3S@1224|Proteobacteria,2VRKV@28216|Betaproteobacteria,3T3VP@506|Alcaligenaceae	28216|Betaproteobacteria	L	Phenylacetate-CoA oxygenase, PaaJ subunit	paaD	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
CMS3_k127_7454214_6	258594.RPA3766	2.151e-77	271.0	COG3396@1|root,COG3396@2|Bacteria,1MVYQ@1224|Proteobacteria,2TRYF@28211|Alphaproteobacteria,3JUK9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Phenylacetic acid catabolic protein	paaC	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
CMS3_k127_7454214_11	1160718.SU9_14591	8.895e-36	147.0	COG3460@1|root,COG3460@2|Bacteria,2IKMJ@201174|Actinobacteria	201174|Actinobacteria	Q	Phenylacetate-CoA oxygenase	paaB	-	-	ko:K02610	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	PaaB
CMS3_k127_7454214_1	43759.JNWK01000004_gene1167	2.442e-152	486.0	COG3396@1|root,COG3396@2|Bacteria,2GMQ3@201174|Actinobacteria	201174|Actinobacteria	S	Phenylacetate-CoA oxygenase	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
CMS3_k127_7454214_8	1463855.JOHV01000020_gene3024	1.001e-69	247.0	COG0600@1|root,COG0600@2|Bacteria,2HDX7@201174|Actinobacteria	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
CMS3_k127_7454214_5	1121381.JNIV01000043_gene1803	2.126e-93	316.0	COG1116@1|root,COG1116@2|Bacteria,1WM71@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
CMS3_k127_7454214_10	1121380.JNIW01000044_gene982	1.072e-43	172.0	COG0600@1|root,COG0600@2|Bacteria,1WM4A@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
CMS3_k127_7454214_3	1380354.JIAN01000007_gene219	8.183e-127	415.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	thiY	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
CMS3_k127_7454214_2	465541.ATCJ01000005_gene6165	4.974e-147	469.0	COG0388@1|root,COG0388@2|Bacteria,2GKRJ@201174|Actinobacteria	201174|Actinobacteria	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
CMS3_k127_7454214_0	345341.KUTG_02737	6.617e-181	587.0	COG0160@1|root,COG0160@2|Bacteria,2GKVH@201174|Actinobacteria,4DZMQ@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	1.2.1.18,1.2.1.27,2.6.1.19	ko:K00140,ko:K00823	ko00250,ko00280,ko00410,ko00562,ko00640,ko00650,ko01100,ko01120,ko01200,map00250,map00280,map00410,map00562,map00640,map00650,map01100,map01120,map01200	M00013,M00027	R00705,R00706,R00908,R00922,R00935,R01648	RC00004,RC00006,RC00062,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_7454214_7	1172180.KB911775_gene5874	1.781e-72	247.0	COG0044@1|root,COG0044@2|Bacteria,2GK4A@201174|Actinobacteria	201174|Actinobacteria	F	Dihydropyrimidinase	hyuA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
CMS3_k127_7468552_18	648996.Theam_1507	6.798e-20	91.0	COG3743@1|root,COG3743@2|Bacteria,2G52I@200783|Aquificae	200783|Aquificae	S	Domain of unknown function (DUF4332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332
CMS3_k127_7468552_21	996637.SGM_5396	6.282e-13	77.0	COG2068@1|root,COG2068@2|Bacteria,2GK5R@201174|Actinobacteria	201174|Actinobacteria	NU	MobA-related protein	nboR	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS3_k127_7468552_13	243231.GSU0012	8.426e-49	194.0	COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,42NBG@68525|delta/epsilon subdivisions,2WKMN@28221|Deltaproteobacteria,43SUB@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemY	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
CMS3_k127_7468552_1	1278073.MYSTI_06112	6.34e-130	429.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42M87@68525|delta/epsilon subdivisions,2WMB0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS3_k127_7468552_8	604331.AUHY01000020_gene1908	6.681e-81	280.0	COG0407@1|root,COG0407@2|Bacteria,1WIHR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
CMS3_k127_7468552_0	518766.Rmar_1199	5.37e-146	475.0	COG0001@1|root,COG0001@2|Bacteria,4NDXG@976|Bacteroidetes,1FIZB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_7468552_3	546271.Selsp_0361	6.424e-115	379.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,4H2HM@909932|Negativicutes	909932|Negativicutes	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
CMS3_k127_7468552_24	649638.Trad_0226	2.808e-05	55.0	COG1587@1|root,COG1587@2|Bacteria	2|Bacteria	H	uroporphyrinogen-III synthase activity	hemD	GO:0003674,GO:0003824,GO:0004852,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.107,2.5.1.61,4.2.1.75	ko:K01719,ko:K01749,ko:K02496,ko:K13542,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084,R03165,R03194	RC00003,RC00871,RC01861,RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0187,iSBO_1134.SBO_3815	HEM4,HemX
CMS3_k127_7468552_10	1385518.N798_13775	2.133e-60	222.0	COG0181@1|root,COG0181@2|Bacteria,2GMWI@201174|Actinobacteria,4FE32@85021|Intrasporangiaceae	201174|Actinobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0510	Porphobil_deam,Porphobil_deamC
CMS3_k127_7468552_17	134676.ACPL_7863	6.228e-23	113.0	COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4DBQN@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0008150,GO:0040007	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
CMS3_k127_7468552_5	1183438.GKIL_1292	1.249e-95	322.0	COG0408@1|root,COG0408@2|Bacteria,1G1PA@1117|Cyanobacteria	1117|Cyanobacteria	H	Involved in the heme and chlorophyll biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
CMS3_k127_7468552_15	1220583.GOACH_05_03220	2.592e-42	162.0	COG3871@1|root,COG3871@2|Bacteria,2IKYK@201174|Actinobacteria,4GE6M@85026|Gordoniaceae	201174|Actinobacteria	S	Pfam:Pyridox_oxidase	-	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0030312,GO:0031406,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_7468552_4	378806.STAUR_2312	7.268e-114	378.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,2YY0V@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
CMS3_k127_7468552_20	1121877.JQKF01000072_gene2093	1.056e-15	81.0	2EG9A@1|root,33A12@2|Bacteria,2GQ7U@201174|Actinobacteria,4CNB5@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7468552_2	1307759.JOMJ01000003_gene1044	3.334e-115	389.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria,2M8CP@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS3_k127_7468552_12	929712.KI912613_gene1358	2.16e-49	193.0	COG5002@1|root,COG5002@2|Bacteria,2I2WW@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_7468552_6	1394178.AWOO02000107_gene5811	7.161e-93	310.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4EGJ6@85012|Streptosporangiales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	tcrA	GO:0000156,GO:0000160,GO:0003674,GO:0005575,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009966,GO:0009968,GO:0009987,GO:0010646,GO:0010648,GO:0016020,GO:0023051,GO:0023052,GO:0023057,GO:0035556,GO:0044464,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070297,GO:0070298,GO:0071944,GO:1902531,GO:1902532	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_7468552_25	1283287.KB822580_gene1729	0.0002607	53.0	COG2268@1|root,COG2268@2|Bacteria,2GKTJ@201174|Actinobacteria,4DX16@85009|Propionibacteriales	201174|Actinobacteria	S	Cellulose-binding protein	abpS	-	-	-	-	-	-	-	-	-	-	-	DivIVA
CMS3_k127_7468552_19	1121382.JQKG01000023_gene1521	3.534e-17	87.0	COG2832@1|root,COG2832@2|Bacteria,1WK7X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function (DUF454)	-	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
CMS3_k127_7468552_9	1121924.ATWH01000014_gene3470	3.388e-78	272.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria,4FSIH@85023|Microbacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_7468552_14	1313172.YM304_37310	4.957e-44	168.0	COG3871@1|root,COG3871@2|Bacteria,2GWY2@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_7468552_7	1121370.AQUY01000002_gene1845	1.979e-86	294.0	COG1108@1|root,COG1108@2|Bacteria,2GJ7H@201174|Actinobacteria,22KZF@1653|Corynebacteriaceae	201174|Actinobacteria	P	ABC-type Mn2 Zn2 transport systems permease components	mntB	-	-	ko:K02075,ko:K09819	-	M00243,M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
CMS3_k127_7468552_11	101510.RHA1_ro02548	2.944e-57	211.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,4FX1P@85025|Nocardiaceae	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	mntC	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
CMS3_k127_7468552_16	1313172.YM304_21830	4.356e-23	104.0	COG0735@1|root,COG0735@2|Bacteria,2HGFN@201174|Actinobacteria,4CND6@84992|Acidimicrobiia	84992|Acidimicrobiia	P	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS3_k127_7468552_22	1045009.AFXQ01000011_gene475	3.529e-11	66.0	COG1120@1|root,COG1120@2|Bacteria,2I5PA@201174|Actinobacteria,1WCNF@1268|Micrococcaceae	201174|Actinobacteria	HP	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS3_k127_7472086_1	398767.Glov_2401	2.575e-97	331.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,43V0Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
CMS3_k127_7472086_0	398767.Glov_2400	2.172e-121	404.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,430HE@68525|delta/epsilon subdivisions,2WVZI@28221|Deltaproteobacteria,43V4N@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
CMS3_k127_7472086_2	398767.Glov_2399	4.48e-96	321.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,43V8M@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	yjiL	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
CMS3_k127_7472086_3	398767.Glov_2398	7.918e-62	225.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42R04@68525|delta/epsilon subdivisions,2WMZ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
CMS3_k127_7481549_11	1385519.N801_12445	1.214e-06	55.0	COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria,4FHJI@85021|Intrasporangiaceae	201174|Actinobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0008150,GO:0040007	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
CMS3_k127_7481549_5	1123320.KB889730_gene6007	1.827e-125	419.0	COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria	201174|Actinobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C
CMS3_k127_7481549_6	1313172.YM304_00020	6.571e-81	282.0	COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria,4CN18@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DNA polymerase III beta subunit	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
CMS3_k127_7481549_7	263358.VAB18032_04485	3.75e-71	253.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4DBQ4@85008|Micromonosporales	201174|Actinobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
CMS3_k127_7481549_12	1242864.D187_004790	0.0002776	49.0	COG5512@1|root,COG5512@2|Bacteria	2|Bacteria	L	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
CMS3_k127_7481549_1	269800.Tfu_0006	6.183e-248	785.0	COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4EGRF@85012|Streptosporangiales	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
CMS3_k127_7481549_0	1229780.BN381_100172	6.164e-266	841.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,3UWEZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CMS3_k127_7481549_10	351607.Acel_0007	8.937e-10	66.0	COG3266@1|root,COG3266@2|Bacteria,2GKZP@201174|Actinobacteria,4ET7R@85013|Frankiales	201174|Actinobacteria	S	Transmembrane domain of unknown function (DUF3566)	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF3566
CMS3_k127_7481549_2	1340493.JNIF01000003_gene3441	1.998e-152	505.0	COG0526@1|root,COG3391@1|root,COG0526@2|Bacteria,COG3391@2|Bacteria,3Y3U8@57723|Acidobacteria	57723|Acidobacteria	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD
CMS3_k127_7481549_4	1123368.AUIS01000002_gene1535	6.967e-128	424.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,2NCHN@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Aminopeptidase P, N-terminal domain	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
CMS3_k127_7481549_8	2850.Phatr37632	2.342e-47	179.0	COG1814@1|root,KOG4473@2759|Eukaryota,2XC42@2836|Bacillariophyta	2836|Bacillariophyta	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
CMS3_k127_7481549_9	208444.JNYY01000026_gene4644	1.046e-23	106.0	COG0748@1|root,COG0748@2|Bacteria,2IFYD@201174|Actinobacteria,4E59B@85010|Pseudonocardiales	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
CMS3_k127_7481549_3	357808.RoseRS_0270	3.196e-148	491.0	COG0596@1|root,COG0596@2|Bacteria,2G6Y2@200795|Chloroflexi	200795|Chloroflexi	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
CMS3_k127_7481932_13	994573.T472_0215450	7.412e-36	150.0	29DE2@1|root,300BX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7481932_14	1229780.BN381_330024	2.687e-21	105.0	COG5340@1|root,COG5340@2|Bacteria	2|Bacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4,DUF559
CMS3_k127_7481932_10	1380393.JHVP01000005_gene3591	8.673e-87	296.0	COG4947@1|root,COG4947@2|Bacteria,2I9H9@201174|Actinobacteria,4EWIE@85013|Frankiales	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS3_k127_7481932_6	649638.Trad_2691	2.623e-122	407.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7481932_12	1122622.ATWJ01000008_gene2999	6.924e-55	207.0	COG2382@1|root,COG2382@2|Bacteria,2I844@201174|Actinobacteria,4FE3S@85021|Intrasporangiaceae	201174|Actinobacteria	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	DUF3327,Esterase
CMS3_k127_7481932_9	1132441.KI519455_gene3317	1.101e-95	328.0	COG1473@1|root,COG1473@2|Bacteria,2GNEG@201174|Actinobacteria,1W8HX@1268|Micrococcaceae	201174|Actinobacteria	S	Peptidase family M20/M25/M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_7481932_0	324602.Caur_2963	0.0	1064.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2G5W2@200795|Chloroflexi,376J5@32061|Chloroflexia	32061|Chloroflexia	H	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS3_k127_7481932_5	926550.CLDAP_11120	1.028e-123	405.0	COG0444@1|root,COG0444@2|Bacteria,2G61B@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_7481932_3	1381123.AYOD01000001_gene1118	1.867e-139	453.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,43HF5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	oppF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_7481932_2	290400.Jann_3294	7.177e-159	520.0	COG0747@1|root,COG0747@2|Bacteria,1MUP8@1224|Proteobacteria,2TQXX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system periplasmic component	MA20_20695	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_7481932_4	1381123.AYOD01000001_gene1120	9.113e-135	436.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TSF3@28211|Alphaproteobacteria,43NDR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	appB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS3_k127_7481932_7	1381123.AYOD01000001_gene1121	6.32e-122	398.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2TTEV@28211|Alphaproteobacteria,43MWA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	N-terminal TM domain of oligopeptide transport permease C	MA20_20685	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
CMS3_k127_7481932_1	1210884.HG799466_gene12501	1.006e-163	526.0	COG0498@1|root,COG0498@2|Bacteria,2IXK6@203682|Planctomycetes	203682|Planctomycetes	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_7481932_15	471854.Dfer_0264	2.521e-15	90.0	COG4733@1|root,COG4733@2|Bacteria,4NK2V@976|Bacteroidetes,47P6C@768503|Cytophagia	976|Bacteroidetes	G	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
CMS3_k127_7481932_8	1469245.JFBG01000080_gene290	1.204e-113	377.0	COG1163@1|root,COG1163@2|Bacteria,1RFPD@1224|Proteobacteria	1224|Proteobacteria	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
CMS3_k127_7509940_15	304371.MCP_2042	1.943e-07	61.0	COG1277@1|root,arCOG02436@2157|Archaea	2157|Archaea	S	ABC-type transport system involved in multi-copper enzyme maturation, permease	nosY2	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
CMS3_k127_7509940_5	448385.sce3847	1.257e-87	306.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2WM9K@28221|Deltaproteobacteria,2YV33@29|Myxococcales	28221|Deltaproteobacteria	E	Threonine dehydratase	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_7509940_8	187272.Mlg_0239	5.915e-63	234.0	2DT9M@1|root,33JBY@2|Bacteria,1NK7A@1224|Proteobacteria,1SIHR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tubulin-tyrosine ligase family	-	-	-	-	-	-	-	-	-	-	-	-	TTL
CMS3_k127_7509940_14	1370125.AUWT01000032_gene1633	6.845e-08	61.0	COG2203@1|root,COG2203@2|Bacteria,2I97I@201174|Actinobacteria	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2
CMS3_k127_7509940_2	1123258.AQXZ01000018_gene1121	1.827e-105	351.0	COG1404@1|root,COG1404@2|Bacteria,2IRXR@201174|Actinobacteria,4FZ50@85025|Nocardiaceae	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS3_k127_7509940_7	1163617.SCD_n02227	9.013e-70	249.0	COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,2WGKB@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
CMS3_k127_7509940_6	479434.Sthe_2682	5.362e-77	273.0	COG2265@1|root,COG2265@2|Bacteria,2G6IV@200795|Chloroflexi,27XG5@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
CMS3_k127_7509940_0	518766.Rmar_2202	2.242e-179	581.0	COG0318@1|root,COG0318@2|Bacteria,4NFPF@976|Bacteroidetes,1FJSN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	IQ	AMP-binding enzyme C-terminal domain	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
CMS3_k127_7509940_10	557599.MKAN_09175	3.068e-31	131.0	COG2105@1|root,COG4195@1|root,COG2105@2|Bacteria,COG4195@2|Bacteria,2GU51@201174|Actinobacteria,235BA@1762|Mycobacteriaceae	201174|Actinobacteria	C	Replication protein	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2,GGACT,Gamma_PGA_hydro
CMS3_k127_7509940_16	1229780.BN381_10335	6.561e-07	56.0	291CY@1|root,2ZNZT@2|Bacteria,2HDEE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7509940_3	1278073.MYSTI_06661	9.291e-97	323.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,42MA4@68525|delta/epsilon subdivisions,2WIPU@28221|Deltaproteobacteria,2YZ50@29|Myxococcales	28221|Deltaproteobacteria	I	Enoyl-(Acyl carrier protein) reductase	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_7509940_9	358823.DF19_00585	3.348e-41	173.0	COG0642@1|root,COG2205@2|Bacteria	358823.DF19_00585|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7509940_4	1108045.GORHZ_169_00540	4.127e-94	319.0	COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,4GB5I@85026|Gordoniaceae	201174|Actinobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
CMS3_k127_7509940_11	994479.GL877878_gene334	3.145e-26	113.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,4E5C4@85010|Pseudonocardiales	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
CMS3_k127_7509940_13	1229780.BN381_10341	2.08e-10	68.0	COG1278@1|root,COG1278@2|Bacteria,2HC2C@201174|Actinobacteria	201174|Actinobacteria	K	Cold shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	-
CMS3_k127_7509940_12	515635.Dtur_1508	3.644e-17	83.0	COG0227@1|root,COG0227@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
CMS3_k127_7509940_1	868595.Desca_1069	2.092e-162	537.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,260I6@186807|Peptococcaceae	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
CMS3_k127_7525748_0	526225.Gobs_2332	1.291e-135	443.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria	201174|Actinobacteria	E	gamma-glutamyltransferase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CMS3_k127_7529832_7	1313172.YM304_38190	5.397e-10	69.0	COG1030@1|root,COG1030@2|Bacteria,2IATM@201174|Actinobacteria	201174|Actinobacteria	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
CMS3_k127_7529832_6	1229780.BN381_100122	4.044e-10	68.0	COG0745@1|root,COG0745@2|Bacteria	1229780.BN381_100122|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7529832_2	574087.Acear_0620	6.555e-76	275.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3WAE6@53433|Halanaerobiales	186801|Clostridia	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
CMS3_k127_7529832_5	264730.PSPPH_0770	2.371e-14	85.0	COG0642@1|root,COG4251@1|root,COG0642@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K20971,ko:K20974	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg,SBP_bac_3,dCache_1
CMS3_k127_7529832_8	1386089.N865_20345	2.971e-06	55.0	COG3832@1|root,COG3832@2|Bacteria,2I61C@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
CMS3_k127_7529832_1	1043493.BBLU01000011_gene279	9.802e-77	274.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_7529832_3	188626.HMPREF0321_1792	1.245e-72	252.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,1ZVX0@145357|Dermacoccaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_7529832_0	913325.N799_10105	2.858e-94	321.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1X2X5@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
CMS3_k127_7529832_4	469383.Cwoe_5290	2.073e-16	80.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4CPEZ@84995|Rubrobacteria	84995|Rubrobacteria	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
CMS3_k127_75549_7	351607.Acel_0544	5.559e-27	122.0	2C0MY@1|root,2ZC2Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_75549_4	1211815.CBYP010000048_gene1668	5.812e-98	340.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4EUJP@85013|Frankiales	201174|Actinobacteria	E	Gamma-glutamyltranspeptidase	ywrD	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CMS3_k127_75549_6	1499967.BAYZ01000095_gene4087	4.032e-78	268.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
CMS3_k127_75549_0	1463855.JOHV01000052_gene2025	9.688e-290	902.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
CMS3_k127_75549_10	1382306.JNIM01000001_gene3477	4.033e-05	54.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	rlpA	-	3.5.1.104	ko:K03642,ko:K03791,ko:K22278	-	-	-	-	ko00000,ko01000	-	GH19	-	3D,DPBB_1,Hydrolase_2,LysM
CMS3_k127_75549_9	1210908.HSB1_16680	1.903e-06	55.0	COG0550@1|root,arCOG06233@2157|Archaea,2Y1NG@28890|Euryarchaeota,23YNS@183963|Halobacteria	183963|Halobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	-	-	-	-	-	-	-	-	-	-	-	-	HHH_5
CMS3_k127_75549_5	526225.Gobs_3980	1.126e-88	304.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4ERPT@85013|Frankiales	201174|Actinobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
CMS3_k127_75549_2	570952.ATVH01000016_gene2528	2.812e-116	382.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2TRT6@28211|Alphaproteobacteria,2JPPP@204441|Rhodospirillales	204441|Rhodospirillales	M	UTP--glucose-1-phosphate uridylyltransferase	exoN	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CMS3_k127_75549_3	1266925.JHVX01000002_gene1002	1.751e-115	383.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,2VHIN@28216|Betaproteobacteria,371UZ@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2,5.3.1.9	ko:K00616,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
CMS3_k127_75549_1	309807.SRU_0080	7.935e-149	489.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,4NDWV@976|Bacteroidetes,1FJJA@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Phosphoglucose isomerase	tal	-	2.2.1.2,5.3.1.9	ko:K00616,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	PGI,TAL_FSA
CMS3_k127_75549_8	1123276.KB893259_gene2508	1.247e-12	70.0	COG1011@1|root,COG1011@2|Bacteria,4NKAU@976|Bacteroidetes,47RGD@768503|Cytophagia	976|Bacteroidetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CMS3_k127_7563890_3	1313172.YM304_38770	2.189e-18	88.0	COG1024@1|root,COG1024@2|Bacteria,2H2U8@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17,4.2.1.18	ko:K01692,ko:K13766	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00036,M00087	R02085,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_7563890_1	1265313.HRUBRA_02440	2.276e-79	280.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
CMS3_k127_7563890_0	1121403.AUCV01000003_gene1787	2.3e-94	334.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2WJ9N@28221|Deltaproteobacteria,2MHX8@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,TrkA_C,Voltage_CLC
CMS3_k127_7563890_2	1136417.AZWE01000012_gene2526	4.166e-21	98.0	COG0842@1|root,COG0842@2|Bacteria,2IITR@201174|Actinobacteria	201174|Actinobacteria	V	Abc-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CMS3_k127_7594916_0	1385510.N781_17030	1.088e-77	271.0	2CUQ5@1|root,32SVT@2|Bacteria,1VW80@1239|Firmicutes,4HW7I@91061|Bacilli,2YBJM@289201|Pontibacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7594916_2	28444.JODQ01000018_gene7278	1.83e-42	167.0	COG0510@1|root,COG0510@2|Bacteria,2HE1I@201174|Actinobacteria	201174|Actinobacteria	M	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS3_k127_7594916_1	266117.Rxyl_2683	1.03e-70	257.0	COG4424@1|root,COG4424@2|Bacteria,2HETZ@201174|Actinobacteria	201174|Actinobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
CMS3_k127_7605066_5	512565.AMIS_48900	3.629e-28	121.0	COG1309@1|root,COG1309@2|Bacteria,2GZ1Y@201174|Actinobacteria,4DDXG@85008|Micromonosporales	201174|Actinobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
CMS3_k127_7605066_0	1114856.C496_04038	1.265e-57	212.0	COG0508@1|root,arCOG01706@2157|Archaea,2XUGY@28890|Euryarchaeota,23V33@183963|Halobacteria	183963|Halobacteria	C	COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
CMS3_k127_7605066_4	419947.MRA_1953	1.799e-29	121.0	2FDS3@1|root,345T0@2|Bacteria,2GUMT@201174|Actinobacteria,23BJN@1762|Mycobacteriaceae	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
CMS3_k127_7605066_1	1299327.I546_4012	1.503e-49	178.0	COG2337@1|root,COG2337@2|Bacteria,2IMGQ@201174|Actinobacteria,23B5D@1762|Mycobacteriaceae	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	mazF5	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
CMS3_k127_7605066_7	479432.Sros_0229	3.217e-06	55.0	COG1595@1|root,COG1595@2|Bacteria,2IJRT@201174|Actinobacteria,4EJ7R@85012|Streptosporangiales	201174|Actinobacteria	K	RNA polymerase, sigma-24 subunit, ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_7605066_3	1499967.BAYZ01000090_gene4936	1.03e-41	169.0	COG0823@1|root,COG0823@2|Bacteria,2NPHZ@2323|unclassified Bacteria	2|Bacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
CMS3_k127_7605066_6	1246995.AFR_02420	6.341e-16	83.0	COG1595@1|root,COG1595@2|Bacteria,2IMAP@201174|Actinobacteria,4DJR1@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r4_2
CMS3_k127_7605066_2	1128421.JAGA01000002_gene1190	1.838e-48	182.0	COG3059@1|root,COG3059@2|Bacteria	2|Bacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF417,DoxX
CMS3_k127_7618585_5	570952.ATVH01000014_gene2068	9.285e-48	184.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_7618585_16	1125971.ASJB01000099_gene2300	2.187e-09	66.0	COG4758@1|root,COG4758@2|Bacteria,2HQN6@201174|Actinobacteria,4E9G5@85010|Pseudonocardiales	201174|Actinobacteria	S	Cell wall-active antibiotics response 4TMS YvqF	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
CMS3_k127_7618585_8	1172179.AUKV01000001_gene912	8.853e-41	160.0	COG3467@1|root,COG3467@2|Bacteria,2IQIK@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
CMS3_k127_7618585_14	765420.OSCT_2991	1.076e-10	71.0	COG2010@1|root,COG3258@1|root,COG2010@2|Bacteria,COG3258@2|Bacteria	2|Bacteria	C	Cytochrome c	qcrC	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005507,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016667,GO:0016669,GO:0016740,GO:0016782,GO:0016783,GO:0018192,GO:0018193,GO:0018198,GO:0018307,GO:0019417,GO:0019538,GO:0020037,GO:0022900,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0046982,GO:0046983,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0098822,GO:1901363,GO:1901564	1.8.2.2	ko:K00406,ko:K03889,ko:K17222,ko:K19713	ko00190,ko00920,ko01100,ko01120,ko02020,map00190,map00920,map01100,map01120,map02020	M00151,M00156,M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cytochrome_CBB3
CMS3_k127_7618585_10	1229780.BN381_450009	8.137e-22	101.0	COG0723@1|root,COG0723@2|Bacteria,2H0R5@201174|Actinobacteria	201174|Actinobacteria	C	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
CMS3_k127_7618585_7	1382306.JNIM01000001_gene1048	4.963e-42	167.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	pcmD	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
CMS3_k127_7618585_2	1313172.YM304_04010	7.318e-75	261.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4CN9T@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cytochrome b/b6/petB	-	-	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
CMS3_k127_7618585_1	671143.DAMO_0766	2.687e-147	487.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	pcmB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9	ko:K03388,ko:K12527	ko00450,ko00680,ko01100,ko01120,ko01200,map00450,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R07229,R11928,R11931,R11943,R11944	RC00011,RC02420	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,FlpD,Pyr_redox_2,Pyr_redox_3
CMS3_k127_7618585_11	1123389.ATXJ01000001_gene565	1.943e-21	105.0	COG2010@1|root,COG2010@2|Bacteria,1WIF2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
CMS3_k127_7618585_9	383372.Rcas_1574	3.003e-37	153.0	COG1622@1|root,COG1622@2|Bacteria,2G8QU@200795|Chloroflexi,3774N@32061|Chloroflexia	32061|Chloroflexia	C	cytochrome c oxidase subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
CMS3_k127_7618585_0	926550.CLDAP_28410	2.243e-197	630.0	COG0843@1|root,COG0843@2|Bacteria,2G628@200795|Chloroflexi	200795|Chloroflexi	C	PFAM cytochrome c oxidase, subunit I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
CMS3_k127_7618585_4	1123360.thalar_02888	4.644e-52	209.0	COG1145@1|root,COG1290@1|root,COG1908@1|root,COG1145@2|Bacteria,COG1290@2|Bacteria,COG1908@2|Bacteria,1QSPU@1224|Proteobacteria,2UQID@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B,FlpD
CMS3_k127_7618585_13	316274.Haur_3763	8.806e-12	79.0	COG3474@1|root,COG3474@2|Bacteria,2GA7P@200795|Chloroflexi,3760W@32061|Chloroflexia	32061|Chloroflexia	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
CMS3_k127_7618585_17	383372.Rcas_1188	1.693e-07	59.0	COG3474@1|root,COG3474@2|Bacteria,2GA7P@200795|Chloroflexi,3760W@32061|Chloroflexia	32061|Chloroflexia	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
CMS3_k127_7618585_18	398767.Glov_1080	0.0007426	51.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,1R3WZ@1224|Proteobacteria,43AG7@68525|delta/epsilon subdivisions,2X5W8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
CMS3_k127_7618585_3	479434.Sthe_0242	4.223e-58	210.0	COG1999@1|root,COG1999@2|Bacteria,2G9UW@200795|Chloroflexi,27ZCD@189775|Thermomicrobia	189775|Thermomicrobia	S	signal sequence binding	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	-
CMS3_k127_7618585_6	479434.Sthe_0241	1.324e-43	166.0	COG1999@1|root,COG1999@2|Bacteria,2G6UW@200795|Chloroflexi,27Z5W@189775|Thermomicrobia	189775|Thermomicrobia	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
CMS3_k127_7618585_15	288000.BBta_4537	3.557e-10	68.0	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria,3JX1P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Copper chaperone PCu(A)C	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
CMS3_k127_7618585_12	1313421.JHBV01000020_gene5217	2.193e-14	78.0	COG0076@1|root,COG0076@2|Bacteria,4NFUP@976|Bacteroidetes	976|Bacteroidetes	E	COG0076 Glutamate decarboxylase and related PLP-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
CMS3_k127_7627905_0	1385519.N801_03195	1.886e-196	625.0	COG2234@1|root,COG2234@2|Bacteria,2IDP0@201174|Actinobacteria,4FE57@85021|Intrasporangiaceae	201174|Actinobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
CMS3_k127_7627905_1	1123276.KB893313_gene3914	4.65e-24	108.0	COG5485@1|root,COG5485@2|Bacteria,4NQU9@976|Bacteroidetes	976|Bacteroidetes	S	Ester cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
CMS3_k127_7627905_3	443152.MDG893_15347	4.884e-08	64.0	COG0697@1|root,COG2510@1|root,COG0697@2|Bacteria,COG2510@2|Bacteria	2|Bacteria	EG	membrane	-	-	-	ko:K08978,ko:K12962	ko01503,map01503	M00721	-	-	ko00000,ko00001,ko00002,ko01005,ko02000	2.A.7.2,2.A.7.22	-	-	EamA
CMS3_k127_7631718_3	234267.Acid_7660	9.184e-116	376.0	COG0167@1|root,COG1149@1|root,COG0167@2|Bacteria,COG1149@2|Bacteria,3Y3D8@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM Dihydroorotate dehydrogenase	-	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_21
CMS3_k127_7631718_5	1122221.JHVI01000023_gene473	1.441e-105	357.0	COG0493@1|root,COG0493@2|Bacteria,1WJAP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	COG0493 NADPH-dependent glutamate synthase beta chain and related	-	-	1.3.1.1	ko:K17722	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Pyr_redox_2
CMS3_k127_7631718_1	1313172.YM304_10800	1.43e-127	419.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_7631718_11	485913.Krac_5508	1.009e-23	111.0	COG2318@1|root,COG2318@2|Bacteria,2G92D@200795|Chloroflexi	2|Bacteria	S	SPTR D1C1B9 DinB family protein	dinB	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB
CMS3_k127_7631718_12	926550.CLDAP_13740	1.5e-18	95.0	2DRD4@1|root,33B9X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7631718_14	1003195.SCAT_2661	3.284e-05	48.0	COG0789@1|root,COG0789@2|Bacteria,2H5GI@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	tipA	-	-	ko:K21744	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1,TipAS
CMS3_k127_7631718_9	246197.MXAN_5120	1.817e-38	149.0	COG0789@1|root,COG0789@2|Bacteria,1REB7@1224|Proteobacteria,4347C@68525|delta/epsilon subdivisions,2X9UQ@28221|Deltaproteobacteria,2YWCK@29|Myxococcales	28221|Deltaproteobacteria	K	TipAS antibiotic-recognition domain	-	-	-	ko:K21744	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1,TipAS
CMS3_k127_7631718_0	1394178.AWOO02000064_gene61	4.119e-156	505.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4EN0I@85012|Streptosporangiales	201174|Actinobacteria	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS3_k127_7631718_13	264198.Reut_A1633	8.885e-07	59.0	COG0730@1|root,COG0730@2|Bacteria,1MWAN@1224|Proteobacteria,2VQPW@28216|Betaproteobacteria,1K07M@119060|Burkholderiaceae	28216|Betaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS3_k127_7631718_2	1121933.AUHH01000003_gene1334	4.859e-121	394.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4DQPN@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
CMS3_k127_7631718_4	1229780.BN381_100074	1.223e-113	374.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,3UW6J@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS3_k127_7631718_6	68170.KL590533_gene5260	2.067e-81	287.0	COG0842@1|root,COG0842@2|Bacteria,2IART@201174|Actinobacteria,4E1XJ@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
CMS3_k127_7631718_7	1121272.KB903290_gene4686	2.378e-73	270.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
CMS3_k127_7631718_8	196162.Noca_3341	1.608e-70	241.0	COG1832@1|root,COG1832@2|Bacteria,2IJYY@201174|Actinobacteria	201174|Actinobacteria	S	PFAM CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
CMS3_k127_7631718_10	512565.AMIS_18720	1.232e-35	145.0	COG0491@1|root,COG0491@2|Bacteria,2GPEX@201174|Actinobacteria	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_843044_1	208439.AJAP_30705	3.185e-67	235.0	COG1028@1|root,COG1028@2|Bacteria,2IT0Y@201174|Actinobacteria,4EEGJ@85010|Pseudonocardiales	201174|Actinobacteria	IQ	RmlD substrate binding domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_843044_0	749927.AMED_6970	2.03e-112	378.0	COG1024@1|root,COG1024@2|Bacteria,2GJ7Z@201174|Actinobacteria,4E2EI@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	echA5	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS3_k127_866804_4	696747.NIES39_E01620	2.471e-05	48.0	COG4663@1|root,COG4663@2|Bacteria,1G1BA@1117|Cyanobacteria,1H7NS@1150|Oscillatoriales	1117|Cyanobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	GO:0003674,GO:0005215,GO:0005342,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0015849,GO:0022857,GO:0031317,GO:0032991,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0046983,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:1903825,GO:1990351	-	-	-	-	-	-	-	-	-	-	DctP
CMS3_k127_866804_1	469371.Tbis_1787	1.41e-47	181.0	COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria,4EF86@85010|Pseudonocardiales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_866804_5	211114.JOEF01000051_gene4753	0.0003824	50.0	2A2F3@1|root,30QS7@2|Bacteria,2HS6G@201174|Actinobacteria,4ECK4@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_866804_2	1184609.KILIM_003_00050	1.173e-23	110.0	COG0782@1|root,COG0782@2|Bacteria,2GNZV@201174|Actinobacteria,4F6TQ@85018|Dermatophilaceae	201174|Actinobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0071944	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
CMS3_k127_866804_3	935866.JAER01000016_gene2068	2.568e-19	95.0	COG0268@1|root,COG0268@2|Bacteria,2IQ73@201174|Actinobacteria,4DS53@85009|Propionibacteriales	201174|Actinobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
CMS3_k127_866804_0	471852.Tcur_3261	4.165e-108	356.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4EGDX@85012|Streptosporangiales	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
CMS3_k127_968221_5	40571.JOEA01000006_gene4408	5.526e-15	79.0	COG0683@1|root,COG0683@2|Bacteria,2GMCF@201174|Actinobacteria,4E14S@85010|Pseudonocardiales	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
CMS3_k127_968221_1	1068978.AMETH_0145	1.27e-104	345.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4DY02@85010|Pseudonocardiales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
CMS3_k127_968221_0	103733.JNYO01000003_gene8319	2.227e-109	360.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4E1TV@85010|Pseudonocardiales	201174|Actinobacteria	E	pfam abc	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
CMS3_k127_968221_4	1121381.JNIV01000012_gene4120	5.369e-19	94.0	COG2050@1|root,COG2050@2|Bacteria,1WK2I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	phenylacetic acid degradation protein PaaD	-	GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
CMS3_k127_968221_3	479435.Kfla_0586	2.705e-47	176.0	COG1268@1|root,COG1268@2|Bacteria,2GJ53@201174|Actinobacteria,4DSED@85009|Propionibacteriales	201174|Actinobacteria	S	BioY family	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
CMS3_k127_968221_2	272558.10175207	2.465e-54	205.0	COG3480@1|root,COG3480@2|Bacteria,1TRUF@1239|Firmicutes,4HBAY@91061|Bacilli,1ZAW6@1386|Bacillus	91061|Bacilli	T	Belongs to the peptidase S16 family	ylbL	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
CMS3_k127_968221_6	97096.XP_007798054.1	0.0008197	51.0	2CUQQ@1|root,2RNQJ@2759|Eukaryota,39W23@33154|Opisthokonta,3NZ4E@4751|Fungi,3QPRI@4890|Ascomycota,214AE@147550|Sordariomycetes	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_970753_1	1089546.AQUI01000002_gene1904	2.302e-14	76.0	COG3311@1|root,COG3311@2|Bacteria	2|Bacteria	K	DNA excision	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
CMS3_k127_970753_2	477641.MODMU_0792	3.593e-08	61.0	COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
CMS3_k127_970753_0	330084.JNYZ01000026_gene2573	4.206e-67	238.0	COG1061@1|root,COG4951@1|root,COG1061@2|Bacteria,COG4951@2|Bacteria,2GIR9@201174|Actinobacteria	201174|Actinobacteria	L	helicase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Helicase_C,Lsr2,ResIII
CMS3_k127_983448_3	1521187.JPIM01000019_gene378	5.563e-36	139.0	COG2343@1|root,COG2343@2|Bacteria,2G79F@200795|Chloroflexi,377I0@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
CMS3_k127_983448_5	1313172.YM304_39170	3.179e-29	121.0	COG0789@1|root,COG0789@2|Bacteria,2GR1T@201174|Actinobacteria,4CN4Z@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix, mercury resistance	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
CMS3_k127_983448_2	1122175.ATXU01000003_gene546	9.204e-79	273.0	COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,4FM9B@85023|Microbacteriaceae	201174|Actinobacteria	O	DnaJ molecular chaperone homology domain	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
CMS3_k127_983448_6	42256.RradSPS_0658	1.68e-23	108.0	COG0576@1|root,COG0576@2|Bacteria,2GP4F@201174|Actinobacteria,4CQBV@84995|Rubrobacteria	84995|Rubrobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
CMS3_k127_983448_0	1463879.JOHP01000014_gene2097	6.369e-244	768.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria	201174|Actinobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
CMS3_k127_983448_4	288000.BBta_3060	2.497e-35	152.0	COG2885@1|root,COG2885@2|Bacteria,1MWHF@1224|Proteobacteria,2TUGX@28211|Alphaproteobacteria,3JTJQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	BON,OmpA
CMS3_k127_983448_7	1122218.KB893653_gene364	3.552e-15	87.0	COG3743@1|root,COG3743@2|Bacteria,1N76A@1224|Proteobacteria,2U93Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	NADH ubiquinone oxidoreductase 41 kD complex I subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_983448_1	309807.SRU_1701	3.787e-183	593.0	COG1960@1|root,COG3793@1|root,COG1960@2|Bacteria,COG3793@2|Bacteria,4NF87@976|Bacteroidetes,1FJZY@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	IP	Acyl-CoA oxidase	-	-	1.3.3.6	ko:K00232	ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146	M00087,M00113	R01175,R01279,R03777,R03857,R03990,R04751,R04754,R07888,R07892,R07896,R07934,R07950	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	ACOX,Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
## 3014 queries scanned
## Total time (seconds): 133.6616928577423
## Rate: 22.55 q/s