## Mon Nov 11 04:04:10 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bins_4635/CMS3_bin.80.fa -m mmseqs --itype genome -o CMS3_bin.80 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/CMS3_bin.80 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
CMS3_k127_1007016_1	1380390.JIAT01000010_gene4354	2.21e-35	143.0	COG1409@1|root,COG1409@2|Bacteria,2GVVJ@201174|Actinobacteria	201174|Actinobacteria	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	Big_5
CMS3_k127_1007016_2	1232410.KI421415_gene2932	1.493e-34	136.0	COG2138@1|root,COG2138@2|Bacteria	2|Bacteria	S	sirohydrochlorin cobaltochelatase activity	cbiX	-	4.99.1.3,4.99.1.4	ko:K03794,ko:K03795	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R05807	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	CbiX
CMS3_k127_1007016_0	378806.STAUR_2315	1.941e-138	456.0	COG1090@1|root,COG4276@1|root,COG1090@2|Bacteria,COG4276@2|Bacteria,1MUB4@1224|Proteobacteria,42PQ2@68525|delta/epsilon subdivisions,2WK6V@28221|Deltaproteobacteria,2YUBK@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase,Polyketide_cyc
CMS3_k127_1007016_4	867845.KI911784_gene1499	2.975e-24	112.0	COG1404@1|root,COG1404@2|Bacteria,2G7GP@200795|Chloroflexi,375SG@32061|Chloroflexia	32061|Chloroflexia	O	TIGRFAM LPXTG-motif cell wall anchor domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
CMS3_k127_1007016_3	886882.PPSC2_c2013	1.588e-30	128.0	COG5012@1|root,COG5012@2|Bacteria,1V5DK@1239|Firmicutes,4HNZ5@91061|Bacilli,26UUT@186822|Paenibacillaceae	91061|Bacilli	S	B12 binding domain	metSY	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
CMS3_k127_1024841_0	1323663.AROI01000014_gene130	8.158e-268	850.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS3_k127_1024841_1	631362.Thi970DRAFT_04891	3.037e-94	334.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RNNF@1236|Gammaproteobacteria,1X05T@135613|Chromatiales	135613|Chromatiales	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
CMS3_k127_1034221_1	1122134.KB893651_gene2066	3.925e-180	581.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,1XMZK@135619|Oceanospirillales	135619|Oceanospirillales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
CMS3_k127_1034221_0	1408473.JHXO01000011_gene3210	2.53e-184	598.0	COG0421@1|root,COG0421@2|Bacteria,4NTHI@976|Bacteroidetes	976|Bacteroidetes	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1039040_2	1296415.JACC01000010_gene2206	0.0004705	50.0	COG2825@1|root,COG2825@2|Bacteria,4NQHJ@976|Bacteroidetes,1I3XJ@117743|Flavobacteriia,2YHSF@290174|Aquimarina	976|Bacteroidetes	M	Outer membrane protein (OmpH-like)	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
CMS3_k127_1039040_1	1379698.RBG1_1C00001G1848	1.332e-87	305.0	COG1044@1|root,COG1044@2|Bacteria,2NNSF@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	ic_1306.c0216	Hexapep,Hexapep_2,LpxD
CMS3_k127_1039040_0	1403819.BATR01000181_gene6175	5.402e-94	327.0	COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,46SG1@74201|Verrucomicrobia,2ITYH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	IM	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	fabZ	-	3.5.1.108,4.2.1.59	ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	M00060,M00083	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	-	-	-	FabA,LpxC
CMS3_k127_1039931_2	518766.Rmar_1207	1.255e-12	74.0	COG2062@1|root,COG2062@2|Bacteria	2|Bacteria	T	phosphohistidine phosphatase, SixA	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
CMS3_k127_1039931_0	234267.Acid_3432	3.296e-69	256.0	COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4DC@57723|Acidobacteria	57723|Acidobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_3,SpoIIE
CMS3_k127_1039931_1	247490.KSU1_B0459	1.674e-30	125.0	COG0363@1|root,COG0363@2|Bacteria,2J0I5@203682|Planctomycetes	203682|Planctomycetes	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
CMS3_k127_1041552_3	1530186.JQEY01000002_gene1720	1.608e-17	94.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,2U9FW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
CMS3_k127_1041552_0	1382306.JNIM01000001_gene2519	1.093e-132	434.0	COG1015@1|root,COG1015@2|Bacteria,2G7S7@200795|Chloroflexi	200795|Chloroflexi	F	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
CMS3_k127_1041552_1	56780.SYN_01482	9.998e-87	301.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,42MGU@68525|delta/epsilon subdivisions,2WIVG@28221|Deltaproteobacteria,2MQVF@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
CMS3_k127_1041552_2	443144.GM21_2548	1.9e-63	231.0	COG3481@1|root,COG3481@2|Bacteria,1NH0C@1224|Proteobacteria,42Q7X@68525|delta/epsilon subdivisions,2WJW2@28221|Deltaproteobacteria,43T29@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	nucleic acid binding OB-fold tRNA helicase-type	yhaM	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
CMS3_k127_1046539_4	452637.Oter_0599	8.257e-05	56.0	COG0457@1|root,COG0457@2|Bacteria,46V1N@74201|Verrucomicrobia,3KA0R@414999|Opitutae	74201|Verrucomicrobia	M	SMART Tetratricopeptide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_11,TPR_16,TPR_2,TPR_8
CMS3_k127_1046539_3	234267.Acid_7472	4.189e-17	87.0	COG1917@1|root,COG1917@2|Bacteria,3Y596@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_1046539_1	1297742.A176_07125	1.268e-89	316.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1046539_2	290397.Adeh_0767	5.533e-61	222.0	COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,43DRN@68525|delta/epsilon subdivisions,2WYQA@28221|Deltaproteobacteria,2Z0CV@29|Myxococcales	28221|Deltaproteobacteria	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
CMS3_k127_1046539_0	391625.PPSIR1_36697	8.768e-115	375.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42PGQ@68525|delta/epsilon subdivisions,2WMJB@28221|Deltaproteobacteria,2YUUP@29|Myxococcales	28221|Deltaproteobacteria	C	Cysteine-rich domain	glpC	-	1.1.5.3	ko:K00113	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17,Fer4_8
CMS3_k127_1052450_2	247490.KSU1_C0023	3.551e-09	61.0	COG0500@1|root,COG2835@1|root,COG0500@2|Bacteria,COG2835@2|Bacteria,2IYVX@203682|Planctomycetes	203682|Planctomycetes	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_1052450_0	1288963.ADIS_4011	8.781e-47	186.0	COG1331@1|root,COG1331@2|Bacteria,4NIPN@976|Bacteroidetes	976|Bacteroidetes	O	Highly conserved protein containing a thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
CMS3_k127_1052450_1	247490.KSU1_C0025	8.61e-12	66.0	COG2192@1|root,COG2192@2|Bacteria,2IYCS@203682|Planctomycetes	2|Bacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS3_k127_1074859_2	1385517.N800_06160	8.218e-06	53.0	COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria,1X3WH@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
CMS3_k127_1074859_0	459349.CLOAM0524	1.978e-116	396.0	COG0737@1|root,COG0737@2|Bacteria,2NQR9@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the 5'-nucleotidase family	soxB	-	3.1.3.5,3.6.1.45	ko:K01081,ko:K11751,ko:K17224	ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120	M00595	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151	RC00017,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_4246,iECS88_1305.ECS88_4396,iLF82_1304.LF82_624	5_nucleotid_C,Metallophos
CMS3_k127_1074859_1	1246484.D479_07217	5.731e-25	120.0	COG2247@1|root,COG2333@1|root,COG2247@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,4H9N3@91061|Bacilli,3NFYQ@45667|Halobacillus	91061|Bacilli	L	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,LTD,Lactamase_B
CMS3_k127_1081295_1	1463825.JNXC01000006_gene2153	2.487e-80	284.0	COG2304@1|root,COG4257@1|root,COG2304@2|Bacteria,COG4257@2|Bacteria,2IDJM@201174|Actinobacteria,4E2D1@85010|Pseudonocardiales	201174|Actinobacteria	V	Calx-beta domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HYR,VWA
CMS3_k127_1081295_0	234267.Acid_4393	7.43e-182	606.0	COG0515@1|root,COG0515@2|Bacteria	234267.Acid_4393|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1081295_3	1437882.AZRU01000025_gene5893	0.0002709	51.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1S96A@1236|Gammaproteobacteria,1YF78@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS3_k127_1081295_2	880073.Calab_3531	7.063e-54	204.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2NNNP@2323|unclassified Bacteria	2|Bacteria	D	CobQ CobB MinD ParA nucleotide binding domain	-	-	-	ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
CMS3_k127_1087109_1	1382359.JIAL01000001_gene85	1.107e-24	122.0	COG2972@1|root,COG2972@2|Bacteria,3Y3NH@57723|Acidobacteria,2JHT4@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	5TM-5TMR_LYT,HATPase_c,His_kinase
CMS3_k127_1087109_0	886293.Sinac_6595	4.517e-27	128.0	COG1807@1|root,COG3063@1|root,COG1807@2|Bacteria,COG3063@2|Bacteria,2J0A8@203682|Planctomycetes	203682|Planctomycetes	NU	O-linked GlcNAc transferase-putative TPR-containing transmembrane protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_1087109_2	1210884.HG799463_gene10108	2.069e-16	94.0	COG0457@1|root,COG0457@2|Bacteria,2J306@203682|Planctomycetes	203682|Planctomycetes	KLT	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_8
CMS3_k127_1087109_3	714943.Mucpa_3816	2.191e-05	47.0	COG0568@1|root,COG0568@2|Bacteria,4NEBF@976|Bacteroidetes,1INNM@117747|Sphingobacteriia	976|Bacteroidetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS3_k127_1091667_2	290397.Adeh_2395	1.717e-29	129.0	COG0457@1|root,COG0457@2|Bacteria,1QX47@1224|Proteobacteria,42Y0X@68525|delta/epsilon subdivisions,2WT7V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,Zincin_1
CMS3_k127_1091667_3	1457250.BBMO01000002_gene2887	1.33e-28	119.0	COG0599@1|root,arCOG02148@2157|Archaea,2XXZ4@28890|Euryarchaeota,23W39@183963|Halobacteria	183963|Halobacteria	S	gamma-carboxymuconolactone decarboxylase subunit	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_1091667_0	1047013.AQSP01000099_gene1499	5.562e-194	616.0	COG0112@1|root,COG0112@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	-	-	2.1.2.1,2.1.2.10,2.2.1.8	ko:K00600,ko:K00605,ko:K18847	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R01221,R02300,R04125,R09099	RC00022,RC00069,RC00112,RC00183,RC01583,RC02834,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C,SHMT
CMS3_k127_1091667_1	1125863.JAFN01000001_gene766	2.126e-110	365.0	COG1055@1|root,COG1055@2|Bacteria,1MXKG@1224|Proteobacteria,42PAX@68525|delta/epsilon subdivisions,2WKEP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Putative citrate transport	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS_2
CMS3_k127_1107931_3	67352.JODS01000041_gene7801	4.416e-10	71.0	COG3420@1|root,COG3420@2|Bacteria,2GNYS@201174|Actinobacteria	201174|Actinobacteria	P	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
CMS3_k127_1107931_0	1267534.KB906757_gene868	8.163e-72	257.0	COG0303@1|root,COG0303@2|Bacteria,3Y3F0@57723|Acidobacteria,2JICE@204432|Acidobacteriia	204432|Acidobacteriia	H	TIGRFAM molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
CMS3_k127_1107931_2	1191523.MROS_1582	1.177e-15	91.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,Fn3-like,Glyco_hydro_3_C,SLH
CMS3_k127_1107931_1	443143.GM18_4316	1.627e-48	194.0	COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,1MU3S@1224|Proteobacteria,42Q3Z@68525|delta/epsilon subdivisions,2WJPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the peptidase S8 family	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Big_2,CUB,He_PIG,Peptidase_S8
CMS3_k127_1149127_0	246197.MXAN_5712	1.034e-126	419.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,42NTY@68525|delta/epsilon subdivisions,2WK4F@28221|Deltaproteobacteria,2YUKQ@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS3_k127_1149127_1	861299.J421_2316	4.909e-75	270.0	COG4603@1|root,COG4603@2|Bacteria,1ZTDA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS3_k127_1161851_0	945713.IALB_2995	8.934e-22	104.0	COG4288@1|root,COG4288@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,Big_5,CHU_C,FlgD_ig,LTD
CMS3_k127_1170353_0	1380600.AUYN01000001_gene2794	7.75e-60	226.0	COG1409@1|root,COG1409@2|Bacteria,4NGK2@976|Bacteroidetes,1I0BV@117743|Flavobacteriia	976|Bacteroidetes	M	Purple acid Phosphatase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
CMS3_k127_1170353_1	314230.DSM3645_22174	4.554e-47	193.0	COG2081@1|root,COG2081@2|Bacteria,2IWW4@203682|Planctomycetes	203682|Planctomycetes	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
CMS3_k127_1172609_6	1443665.JACA01000014_gene4453	3.995e-05	50.0	2C7KN@1|root,32RJD@2|Bacteria,4NR1V@976|Bacteroidetes,1I42C@117743|Flavobacteriia,2YJFG@290174|Aquimarina	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1172609_4	1121920.AUAU01000011_gene222	4.325e-50	183.0	COG3189@1|root,COG3189@2|Bacteria,3Y86R@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
CMS3_k127_1172609_1	530564.Psta_0329	8.124e-160	517.0	COG0205@1|root,COG0205@2|Bacteria,2IX8A@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfk	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K00895	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
CMS3_k127_1172609_0	373994.Riv7116_5818	2.449e-306	959.0	COG1554@1|root,COG1554@2|Bacteria,1G0DN@1117|Cyanobacteria,1HIEI@1161|Nostocales	1117|Cyanobacteria	G	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
CMS3_k127_1172609_2	469371.Tbis_2886	7.774e-83	282.0	COG0637@1|root,COG0637@2|Bacteria,2I2IT@201174|Actinobacteria,4DZZF@85010|Pseudonocardiales	201174|Actinobacteria	S	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	pgcM	GO:0003674,GO:0003824,GO:0008801,GO:0016853,GO:0016866,GO:0016868	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase
CMS3_k127_1172609_3	1279009.ADICEAN_03372	1.914e-76	266.0	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,47NT4@768503|Cytophagia	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS3_k127_118902_2	1123248.KB893314_gene3680	0.0005785	53.0	COG2730@1|root,COG3055@1|root,COG2730@2|Bacteria,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase,Kelch_1,Kelch_4,Kelch_6,RicinB_lectin_2
CMS3_k127_118902_0	530564.Psta_4082	3.289e-46	188.0	COG3209@1|root,COG4932@1|root,COG3209@2|Bacteria,COG4932@2|Bacteria,2IYH3@203682|Planctomycetes	203682|Planctomycetes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Dockerin_1,SdrD_B
CMS3_k127_118902_1	459349.CLOAM1690	8.103e-08	65.0	COG1361@1|root,COG1361@2|Bacteria,2NS3P@2323|unclassified Bacteria	2|Bacteria	M	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FlgD_ig,Peptidase_C25,Peptidase_C25_C,Propeptide_C25
CMS3_k127_1204824_3	1430331.EP10_03315	4.727e-58	209.0	COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,4H9YS@91061|Bacilli,1WFTF@129337|Geobacillus	91061|Bacilli	E	histidine ammonia-lyase activity	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
CMS3_k127_1204824_2	1121396.KB893001_gene3985	1.509e-81	282.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42MFD@68525|delta/epsilon subdivisions,2WJCZ@28221|Deltaproteobacteria,2MI2F@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Sir2 family	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
CMS3_k127_1204824_1	696281.Desru_2232	1.122e-83	310.0	COG1199@1|root,COG2176@1|root,COG1199@2|Bacteria,COG2176@2|Bacteria,1TQHQ@1239|Firmicutes,25C6H@186801|Clostridia,2601V@186807|Peptococcaceae	186801|Clostridia	L	helicase involved in DNA repair and perhaps also replication	dinG	-	2.7.7.7,3.6.4.12	ko:K02342,ko:K03722	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,RNase_T,RadC,ResIII
CMS3_k127_1204824_0	1125863.JAFN01000001_gene929	3.271e-94	318.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
CMS3_k127_1207884_1	204669.Acid345_2966	7.477e-171	547.0	COG2079@1|root,COG2079@2|Bacteria,3Y5N1@57723|Acidobacteria,2JK64@204432|Acidobacteriia	204432|Acidobacteriia	S	MmgE/PrpD family	-	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
CMS3_k127_1207884_2	1047013.AQSP01000140_gene2449	2.115e-38	164.0	COG1418@1|root,COG1418@2|Bacteria,2NPXI@2323|unclassified Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950,ko:K09163	-	-	-	-	ko00000	-	-	-	HD
CMS3_k127_1207884_0	880073.Calab_1833	6.125e-233	736.0	COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria,2NNYT@2323|unclassified Bacteria	2|Bacteria	E	Aconitase family (aconitate hydratase)	leuD	-	4.2.1.33,4.2.1.35,4.2.1.36	ko:K01703,ko:K01704,ko:K01705	ko00290,ko00300,ko00660,ko00966,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00966,map01100,map01110,map01120,map01130,map01210,map01230	M00030,M00432,M00433,M00535	R03896,R03898,R03968,R04001,R04371,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
CMS3_k127_1220861_1	28564.XP_002483884.1	3.044e-69	251.0	KOG4155@1|root,KOG4155@2759|Eukaryota,3AG0Y@33154|Opisthokonta,3Q4RG@4751|Fungi,3RN16@4890|Ascomycota,20UKC@147545|Eurotiomycetes,3SE9V@5042|Eurotiales	4751|Fungi	S	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,NACHT,PNP_UDP_1,WD40
CMS3_k127_1220861_2	1192034.CAP_2998	1.163e-24	120.0	COG1309@1|root,COG1309@2|Bacteria,1MYFS@1224|Proteobacteria,42T8F@68525|delta/epsilon subdivisions,2WPCH@28221|Deltaproteobacteria,2Z34T@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_1220861_0	483219.LILAB_01975	9.78e-277	865.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42M33@68525|delta/epsilon subdivisions,2WJGS@28221|Deltaproteobacteria,2YU96@29|Myxococcales	28221|Deltaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
CMS3_k127_1230810_0	1123248.KB893370_gene5054	3.272e-161	525.0	COG1112@1|root,COG2251@1|root,COG1112@2|Bacteria,COG2251@2|Bacteria,4NEK7@976|Bacteroidetes	976|Bacteroidetes	L	COG1112 Superfamily I DNA and RNA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,AAA_30,RNase_H_2
CMS3_k127_1230810_1	331113.SNE_A06590	7.472e-50	192.0	COG4247@1|root,COG4247@2|Bacteria	2|Bacteria	I	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)	phy	-	3.1.3.8	ko:K01083	ko00562,map00562	-	R03371	RC00078	ko00000,ko00001,ko01000	-	-	-	NHL,Phytase
CMS3_k127_1230810_2	870967.VIS19158_06535	1.305e-16	86.0	COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,1P0NB@1224|Proteobacteria,1RPQZ@1236|Gammaproteobacteria,1XSNC@135623|Vibrionales	135623|Vibrionales	G	COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)	VVA0192	-	-	ko:K11201,ko:K11202,ko:K11203	-	M00306	-	-	ko00000,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
CMS3_k127_1297398_1	1232410.KI421421_gene3267	3.507e-61	219.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,42QAM@68525|delta/epsilon subdivisions,2WM04@28221|Deltaproteobacteria,43U4W@69541|Desulfuromonadales	28221|Deltaproteobacteria	IQ	KR domain	-	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_1297398_2	867903.ThesuDRAFT_00732	4.163e-27	122.0	COG1309@1|root,COG1309@2|Bacteria,1V3QD@1239|Firmicutes,24TIW@186801|Clostridia	186801|Clostridia	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
CMS3_k127_1297398_0	420324.KI911970_gene1564	3.945e-304	943.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
CMS3_k127_1306167_1	945713.IALB_1477	3.638e-59	219.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K13276	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
CMS3_k127_1306167_0	313628.LNTAR_10466	8.888e-71	251.0	COG0847@1|root,COG0847@2|Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
CMS3_k127_1343461_0	909613.UO65_3906	0.0006694	53.0	COG0457@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator, SARP family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,NB-ARC,TPR_12,Trans_reg_C
CMS3_k127_1346559_3	452637.Oter_0373	8.392e-39	148.0	COG1509@1|root,COG1509@2|Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	kamA3	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
CMS3_k127_1346559_1	861299.J421_1661	3.187e-152	494.0	COG0534@1|root,COG0534@2|Bacteria,1ZUGI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS3_k127_1346559_0	1121930.AQXG01000010_gene3099	4.032e-261	831.0	COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes,1IQMB@117747|Sphingobacteriia	976|Bacteroidetes	O	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
CMS3_k127_1346559_5	706587.Desti_4763	2.669e-23	110.0	COG3025@1|root,COG3025@2|Bacteria	2|Bacteria	S	triphosphatase activity	ygiF	-	3.6.1.25	ko:K18446	-	-	-	-	ko00000,ko01000	-	-	-	CHAD,CYTH
CMS3_k127_1346559_6	861299.J421_3051	6.728e-22	107.0	COG0597@1|root,COG0597@2|Bacteria,1ZTVD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	-	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
CMS3_k127_1346559_2	1121448.DGI_1634	3.817e-83	295.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria,2MF83@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
CMS3_k127_1346559_4	404380.Gbem_2872	3.826e-38	154.0	2DQIT@1|root,33749@2|Bacteria,1N9CN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
CMS3_k127_1347983_0	502025.Hoch_3436	5.791e-103	349.0	COG1196@1|root,COG1196@2|Bacteria,1R3XQ@1224|Proteobacteria,42YF5@68525|delta/epsilon subdivisions,2WUDV@28221|Deltaproteobacteria,2YUE5@29|Myxococcales	28221|Deltaproteobacteria	D	HAD superfamily (subfamily IG) hydrolase 5'-Nucleotidase	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid
CMS3_k127_1347983_1	1382359.JIAL01000001_gene1562	1.211e-15	82.0	29ITM@1|root,305QZ@2|Bacteria,3Y4F3@57723|Acidobacteria,2JJ2C@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1356157_5	1210884.HG799464_gene11089	2.918e-07	63.0	COG2148@1|root,COG2148@2|Bacteria,2IX7E@203682|Planctomycetes	203682|Planctomycetes	M	involved in lipopolysaccharide	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
CMS3_k127_1356157_2	760568.Desku_0718	3.732e-78	273.0	COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia,261FK@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
CMS3_k127_1356157_0	351607.Acel_0413	2.376e-138	448.0	COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria,4ET4A@85013|Frankiales	201174|Actinobacteria	M	PFAM Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CMS3_k127_1356157_4	518766.Rmar_2624	1.847e-32	146.0	COG1596@1|root,COG1596@2|Bacteria,4P33T@976|Bacteroidetes	976|Bacteroidetes	M	Polysaccharide biosynthesis/export protein	-	-	-	-	-	-	-	-	-	-	-	-	Poly_export,SLBB
CMS3_k127_1356157_3	458817.Shal_1233	1.478e-54	199.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,2Q8IB@267890|Shewanellaceae	1236|Gammaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474	DHHA1,tRNA-synt_2c,tRNA_SAD
CMS3_k127_1356157_1	1125863.JAFN01000001_gene3028	2.126e-108	366.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
CMS3_k127_1376127_0	518766.Rmar_0508	1.911e-75	270.0	COG2203@1|root,COG2204@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,1FJ5I@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	Sigma54_activat
CMS3_k127_1376127_3	309801.trd_0841	3.703e-07	63.0	COG3307@1|root,COG3307@2|Bacteria,2G6TE@200795|Chloroflexi,27XXU@189775|Thermomicrobia	189775|Thermomicrobia	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
CMS3_k127_1376127_1	635013.TherJR_2108	6.145e-39	161.0	COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,261PX@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_1376127_2	1232452.BAIB02000016_gene2434	6.24e-09	64.0	COG0613@1|root,COG0613@2|Bacteria,1V6HN@1239|Firmicutes,24DQ6@186801|Clostridia	186801|Clostridia	S	DNA polymerase alpha chain like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1382863_1	1453500.AT05_00055	8.484e-57	211.0	COG1028@1|root,COG1028@2|Bacteria,4NFXD@976|Bacteroidetes,1HX5Z@117743|Flavobacteriia	976|Bacteroidetes	IQ	with different specificities (Related to short-chain alcohol	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_1382863_0	706587.Desti_2026	6.265e-112	381.0	COG4262@1|root,COG4262@2|Bacteria,1QX9D@1224|Proteobacteria,42Q62@68525|delta/epsilon subdivisions,2WMHX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Spermine spermidine synthase	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
CMS3_k127_138963_4	994479.GL877879_gene5375	3.143e-15	79.0	COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria,4E09P@85010|Pseudonocardiales	201174|Actinobacteria	C	NADPH quinone reductase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_138963_1	867903.ThesuDRAFT_01144	1.879e-87	299.0	COG1028@1|root,COG1028@2|Bacteria,1TR53@1239|Firmicutes,247XS@186801|Clostridia	186801|Clostridia	IQ	Dehydrogenase	ydaD	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_138963_5	393921.HQ45_03355	2.156e-05	51.0	COG3631@1|root,COG3631@2|Bacteria,4NQEU@976|Bacteroidetes	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
CMS3_k127_138963_0	335543.Sfum_2279	9.316e-140	473.0	COG1404@1|root,COG1404@2|Bacteria,1PFBD@1224|Proteobacteria,43A1G@68525|delta/epsilon subdivisions,2X9U2@28221|Deltaproteobacteria,2MSGE@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS3_k127_138963_2	1379698.RBG1_1C00001G1345	3.873e-85	297.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2NQ3V@2323|unclassified Bacteria	2|Bacteria	KT	COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit	rsbU	-	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	GAF,GAF_2,HATPase_c_2,SSF,SpoIIE
CMS3_k127_138963_3	1089550.ATTH01000001_gene1585	5.097e-79	276.0	COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes,1FIK8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
CMS3_k127_13952_1	349521.HCH_04109	1.519e-52	190.0	COG5113@1|root,COG3236@2|Bacteria,1RK58@1224|Proteobacteria,1T154@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products. Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do. Helps maintain flavin levels. May act on other substrates in vivo. Has no activity against GTP, nucleoside monophosphates or ADP-ribose. Is Required for swarming motility	ybiA	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016070,GO:0016787,GO:0016798,GO:0016799,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901135,GO:1901360	-	ko:K09935	-	-	-	-	ko00000	-	-	-	DUF1768
CMS3_k127_13952_0	880073.Calab_3424	1.592e-65	234.0	COG3698@1|root,COG3698@2|Bacteria,2NR44@2323|unclassified Bacteria	2|Bacteria	S	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
CMS3_k127_13952_2	1242864.D187_009043	1.748e-44	163.0	2CD85@1|root,32RB4@2|Bacteria,1NGNI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1398877_0	1123354.AUDR01000013_gene825	5.214e-76	263.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,1KRCP@119069|Hydrogenophilales	119069|Hydrogenophilales	F	AICARFT/IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
CMS3_k127_1398877_1	1123023.JIAI01000002_gene4570	4.661e-16	92.0	COG4412@1|root,COG4412@2|Bacteria,2GMKQ@201174|Actinobacteria	201174|Actinobacteria	M	PFAM peptidase M6, immune inhibitor A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
CMS3_k127_140376_0	1254432.SCE1572_24070	0.0	1008.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42M0A@68525|delta/epsilon subdivisions,2WIQY@28221|Deltaproteobacteria,2Z2XJ@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787,ko:K15726	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.2,2.A.6.1.4	-	-	ACR_tran
CMS3_k127_140376_3	448385.sce2736	6.449e-122	405.0	COG0845@1|root,COG0845@2|Bacteria,1MX8W@1224|Proteobacteria,42T6A@68525|delta/epsilon subdivisions,2WPV8@28221|Deltaproteobacteria,2YUNA@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
CMS3_k127_140376_5	448385.sce2735	3.375e-36	139.0	COG0845@1|root,COG0845@2|Bacteria,1P3X6@1224|Proteobacteria,431K1@68525|delta/epsilon subdivisions,2WWAD@28221|Deltaproteobacteria,2Z240@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_140376_2	215803.DB30_0854	1.251e-151	488.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2X1W0@28221|Deltaproteobacteria,2YUZR@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	-	-	2.6.1.17	ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_140376_4	926569.ANT_27040	1.301e-78	270.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	ycdQ	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
CMS3_k127_140376_1	215803.DB30_7050	3.224e-194	633.0	COG0457@1|root,COG0457@2|Bacteria,1NTKG@1224|Proteobacteria,439AJ@68525|delta/epsilon subdivisions,2X4I4@28221|Deltaproteobacteria,2YZ2B@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1413229_3	1352941.M877_21225	0.0006103	52.0	COG4886@1|root,COG4886@2|Bacteria,2ICIK@201174|Actinobacteria	201174|Actinobacteria	S	Leucine-rich repeat (LRR) protein	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	LRR_4
CMS3_k127_1413229_0	448385.sce7999	1.597e-126	429.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,2Z30B@29|Myxococcales	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
CMS3_k127_1413229_2	420247.Msm_1279	2.161e-38	147.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,23P3X@183925|Methanobacteria	183925|Methanobacteria	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
CMS3_k127_1413229_1	479434.Sthe_0112	1.901e-44	164.0	COG0183@1|root,COG0183@2|Bacteria,2G63J@200795|Chloroflexi,27YZ2@189775|Thermomicrobia	189775|Thermomicrobia	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_1414409_3	1089550.ATTH01000001_gene1070	1.57e-06	56.0	COG3391@1|root,COG4733@1|root,COG3391@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,EGF_3,Fibrinogen_C,VCBS,fn3
CMS3_k127_1414409_0	1192034.CAP_0368	9.164e-100	338.0	COG0639@1|root,COG0639@2|Bacteria,1QEIM@1224|Proteobacteria,4307J@68525|delta/epsilon subdivisions,2WV6F@28221|Deltaproteobacteria,2YVCQ@29|Myxococcales	28221|Deltaproteobacteria	T	COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS3_k127_1414409_1	118166.JH976537_gene3679	7.356e-87	296.0	COG0412@1|root,COG0412@2|Bacteria,1G3JS@1117|Cyanobacteria,1HA80@1150|Oscillatoriales	1117|Cyanobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
CMS3_k127_1414409_2	543728.Vapar_3891	1.825e-44	164.0	COG3408@1|root,COG3408@2|Bacteria,1PGVT@1224|Proteobacteria,2VHTH@28216|Betaproteobacteria,4ACK3@80864|Comamonadaceae	28216|Betaproteobacteria	G	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_100
CMS3_k127_1443709_0	378806.STAUR_6932	1.206e-228	731.0	COG3962@1|root,COG3962@2|Bacteria,1QX94@1224|Proteobacteria,43C26@68525|delta/epsilon subdivisions,2X7CR@28221|Deltaproteobacteria,2YYEC@29|Myxococcales	28221|Deltaproteobacteria	E	Thiamine pyrophosphate enzyme, central domain	-	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS3_k127_1443709_1	378806.STAUR_6933	3.992e-91	311.0	COG3718@1|root,COG3718@2|Bacteria,1MWGD@1224|Proteobacteria,42VSE@68525|delta/epsilon subdivisions,2WRJ3@28221|Deltaproteobacteria,2YY72@29|Myxococcales	28221|Deltaproteobacteria	G	KduI/IolB family	-	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
CMS3_k127_1443709_2	743719.PaelaDRAFT_5082	6.461e-13	70.0	COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,4HAKY@91061|Bacilli,26QTU@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	idhA	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS3_k127_1449100_1	1519464.HY22_10230	2.057e-64	230.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1FEH6@1090|Chlorobi	1090|Chlorobi	GM	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
CMS3_k127_1449100_0	525904.Tter_2810	8.828e-108	361.0	COG0399@1|root,COG0399@2|Bacteria,2NNS2@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the DegT DnrJ EryC1 family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS3_k127_1451842_1	1267535.KB906767_gene1933	1.652e-45	167.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	ywzG	-	-	-	-	-	-	-	-	-	-	-	PadR
CMS3_k127_1451842_0	404589.Anae109_3084	4.821e-77	278.0	2C6TZ@1|root,32RHS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1455927_0	1379698.RBG1_1C00001G1865	3.149e-107	375.0	COG0557@1|root,COG0557@2|Bacteria,2NNV2@2323|unclassified Bacteria	2|Bacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573,ko:K12585	ko03018,map03018	M00391	-	-	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
CMS3_k127_1458507_0	1121468.AUBR01000051_gene2000	1.183e-124	414.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,42F2X@68295|Thermoanaerobacterales	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
CMS3_k127_1458507_1	1449063.JMLS01000004_gene2600	4.96e-22	104.0	COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,4HC55@91061|Bacilli,26SNK@186822|Paenibacillaceae	91061|Bacilli	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
CMS3_k127_1465491_0	357808.RoseRS_1213	5.912e-93	313.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,2G5M1@200795|Chloroflexi,376VN@32061|Chloroflexia	32061|Chloroflexia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
CMS3_k127_1465491_2	1162668.LFE_1500	1.542e-38	153.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Cytochrome_C554,DUF11,SLH
CMS3_k127_1465491_1	555779.Dthio_PD2279	3.796e-82	293.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_1465491_5	56780.SYN_00862	1.827e-07	59.0	COG3945@1|root,COG3945@2|Bacteria,1RG8J@1224|Proteobacteria,42S6P@68525|delta/epsilon subdivisions,2WNYW@28221|Deltaproteobacteria,2MS0X@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
CMS3_k127_1465491_3	278963.ATWD01000001_gene2227	1.696e-20	97.0	COG1959@1|root,COG1959@2|Bacteria,3Y4X0@57723|Acidobacteria,2JJEV@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS3_k127_1465491_4	944480.ATUV01000001_gene1024	1.745e-19	91.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,42NRM@68525|delta/epsilon subdivisions,2WJ0S@28221|Deltaproteobacteria,2M6J4@213113|Desulfurellales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoH	-	-	ko:K03086,ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS3_k127_1479574_1	867903.ThesuDRAFT_00468	3.844e-133	441.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,3WCSH@538999|Clostridiales incertae sedis	186801|Clostridia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
CMS3_k127_1479574_7	1408444.JHYC01000002_gene541	6.145e-12	67.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,1SGDJ@1236|Gammaproteobacteria,1JF92@118969|Legionellales	118969|Legionellales	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
CMS3_k127_1479574_8	469383.Cwoe_5949	1.482e-05	52.0	COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria,4CQCA@84995|Rubrobacteria	84995|Rubrobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
CMS3_k127_1479574_6	637389.Acaty_c2682	9.918e-17	85.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,2ND8W@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
CMS3_k127_1479574_3	880073.Calab_0952	1.398e-70	264.0	COG0706@1|root,COG0706@2|Bacteria,2NP6C@2323|unclassified Bacteria	2|Bacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
CMS3_k127_1479574_4	1382358.JHVN01000001_gene1264	1.911e-33	139.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,4HHHU@91061|Bacilli,21VRU@150247|Anoxybacillus	91061|Bacilli	S	Putative single-stranded nucleic acids-binding domain	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
CMS3_k127_1479574_2	1121468.AUBR01000004_gene114	9.845e-103	351.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia,42FFQ@68295|Thermoanaerobacterales	186801|Clostridia	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
CMS3_k127_1479574_0	521674.Plim_2536	1.067e-185	602.0	COG0445@1|root,COG0445@2|Bacteria,2IXGA@203682|Planctomycetes	203682|Planctomycetes	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
CMS3_k127_1479574_5	1536769.P40081_37485	6.419e-21	102.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,4HAAZ@91061|Bacilli,26QDI@186822|Paenibacillaceae	91061|Bacilli	J	Specifically methylates the N7 position of guanine in position 535 of 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
CMS3_k127_1500030_2	234267.Acid_0492	2.184e-34	133.0	COG2010@1|root,COG2010@2|Bacteria,3Y3HF@57723|Acidobacteria	57723|Acidobacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
CMS3_k127_1500030_1	1123242.JH636434_gene3646	2.037e-52	197.0	COG2010@1|root,COG2010@2|Bacteria,2J13R@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
CMS3_k127_1500030_0	1128421.JAGA01000003_gene2874	5.304e-121	402.0	COG4531@1|root,COG4531@2|Bacteria,2NP5Y@2323|unclassified Bacteria	2|Bacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	actF	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1500030_3	234267.Acid_0495	4.838e-18	89.0	2EJZ3@1|root,33DPP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1514197_0	502025.Hoch_2162	8.59e-136	441.0	COG1233@1|root,COG3349@1|root,COG4638@1|root,COG1233@2|Bacteria,COG3349@2|Bacteria,COG4638@2|Bacteria,1RAVN@1224|Proteobacteria,433WH@68525|delta/epsilon subdivisions,2X3VQ@28221|Deltaproteobacteria,2YX9K@29|Myxococcales	28221|Deltaproteobacteria	Q	FAD dependent oxidoreductase	-	-	-	ko:K09879	ko00906,map00906	-	R07541,R07560,R07857,R07858	RC01901,RC01965	ko00000,ko00001	-	-	-	Amino_oxidase
CMS3_k127_1514197_1	502025.Hoch_2162	1.683e-111	371.0	COG1233@1|root,COG3349@1|root,COG4638@1|root,COG1233@2|Bacteria,COG3349@2|Bacteria,COG4638@2|Bacteria,1RAVN@1224|Proteobacteria,433WH@68525|delta/epsilon subdivisions,2X3VQ@28221|Deltaproteobacteria,2YX9K@29|Myxococcales	28221|Deltaproteobacteria	Q	FAD dependent oxidoreductase	-	-	-	ko:K09879	ko00906,map00906	-	R07541,R07560,R07857,R07858	RC01901,RC01965	ko00000,ko00001	-	-	-	Amino_oxidase
CMS3_k127_1514197_2	697282.Mettu_2031	9.501e-55	194.0	COG3258@1|root,COG3258@2|Bacteria,1N1U2@1224|Proteobacteria,1SD42@1236|Gammaproteobacteria,1XFNF@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1514197_3	743836.AYNA01000037_gene806	3.924e-24	104.0	COG1409@1|root,COG1409@2|Bacteria,1MUQJ@1224|Proteobacteria,2TTSK@28211|Alphaproteobacteria,36YJE@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS3_k127_1525743_1	1267533.KB906737_gene1567	1.206e-32	137.0	COG2945@1|root,COG2945@2|Bacteria,3Y35I@57723|Acidobacteria,2JIVZ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4
CMS3_k127_1525743_0	1047013.AQSP01000094_gene20	7.76e-176	568.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2NNXZ@2323|unclassified Bacteria	2|Bacteria	E	Formiminotransferase-cyclodeaminase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
CMS3_k127_1525743_3	1526927.Plano_1571	1.594e-17	93.0	COG1409@1|root,COG1409@2|Bacteria,1VHY9@1239|Firmicutes,4HPAR@91061|Bacilli	91061|Bacilli	S	Phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS3_k127_1525743_2	518766.Rmar_0611	4.239e-32	138.0	COG1376@1|root,COG1376@2|Bacteria,4P35B@976|Bacteroidetes	976|Bacteroidetes	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
CMS3_k127_1525888_1	1265845.PWEIH_11430	4.968e-48	176.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,4HGXA@91061|Bacilli,26IMU@186820|Listeriaceae	91061|Bacilli	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
CMS3_k127_1525888_4	861299.J421_3313	1.966e-31	129.0	COG0394@1|root,COG0394@2|Bacteria,1ZTSE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Low molecular weight phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
CMS3_k127_1525888_6	410359.Pcal_1129	2.188e-23	111.0	COG0009@1|root,arCOG01952@2157|Archaea,2XPW0@28889|Crenarchaeota	28889|Crenarchaeota	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua5	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
CMS3_k127_1525888_2	768066.HELO_1531	3.397e-42	164.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,1XJ83@135619|Oceanospirillales	135619|Oceanospirillales	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
CMS3_k127_1525888_0	717605.Theco_3090	2.746e-115	385.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,4HA70@91061|Bacilli,26SBN@186822|Paenibacillaceae	91061|Bacilli	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS05245,iYO844.BSU06530	GARS_A,GARS_C,GARS_N
CMS3_k127_1525888_5	318424.EU78_16565	1.145e-26	125.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,2GMC0@201174|Actinobacteria,235F4@1762|Mycobacteriaceae	201174|Actinobacteria	L	DNA polymerase III, epsilon subunit	dnaQ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
CMS3_k127_1525888_3	1382356.JQMP01000003_gene1897	5.256e-35	138.0	COG3358@1|root,COG3358@2|Bacteria,2G9CX@200795|Chloroflexi,27Z2J@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
CMS3_k127_1535056_0	518766.Rmar_0089	1.135e-230	743.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_1535056_1	768671.ThimaDRAFT_0873	5.082e-54	193.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGB@1236|Gammaproteobacteria,1X1MI@135613|Chromatiales	135613|Chromatiales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CMS3_k127_1539799_1	1379698.RBG1_1C00001G0646	1.669e-126	414.0	COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
CMS3_k127_1539799_4	1128421.JAGA01000002_gene285	5.639e-13	81.0	COG0859@1|root,COG0859@2|Bacteria,2NP5P@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase, family 9	-	-	-	ko:K02843,ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS3_k127_1539799_0	1379698.RBG1_1C00001G1033	3.917e-155	514.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	msbA	-	-	ko:K02021,ko:K06147,ko:K06148,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_1539799_3	644282.Deba_2092	5.115e-47	184.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42NEW@68525|delta/epsilon subdivisions,2WJNJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM glycosyl transferase family 9	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS3_k127_1539799_2	404589.Anae109_2578	1.585e-68	245.0	COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_0922	CTP_transf_like,PfkB
CMS3_k127_1539799_5	546271.Selsp_0389	1.523e-11	70.0	COG0615@1|root,COG0615@2|Bacteria,1UJSU@1239|Firmicutes,4H4AI@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE_2	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
CMS3_k127_1548680_1	234267.Acid_0090	1.607e-36	151.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	msrA	-	1.1.98.6,1.8.1.9,1.8.4.11,1.8.4.12	ko:K00384,ko:K12057,ko:K12267,ko:K21636	ko00230,ko00240,ko00450,ko01100,map00230,map00240,map00450,map01100	M00053	R02016,R03596,R09372,R11633,R11634,R11635,R11636	RC00013,RC00613,RC02518,RC02873	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.7.11.1	-	-	AhpC-TSA,PMSR,Pyr_redox_2,SelR,Thioredoxin,Thioredoxin_3,Thioredoxin_7,TraF
CMS3_k127_1548680_0	518766.Rmar_1847	3.02e-76	270.0	28PR2@1|root,2ZCCZ@2|Bacteria,4NMVK@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1551399_3	234267.Acid_5658	1.098e-06	57.0	COG0457@1|root,COG0457@2|Bacteria,3Y5YE@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1551399_0	637905.SVI_3141	7.552e-75	266.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,2Q9VE@267890|Shewanellaceae	1236|Gammaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CMS3_k127_1551399_1	595537.Varpa_5318	1.657e-19	100.0	COG1247@1|root,COG1247@2|Bacteria,1R6UW@1224|Proteobacteria,2W2QC@28216|Betaproteobacteria,4AHQC@80864|Comamonadaceae	28216|Betaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_1551399_2	1242864.D187_003289	2.524e-11	76.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,43AGY@68525|delta/epsilon subdivisions,2X5WX@28221|Deltaproteobacteria,2YWWR@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,TPR_4,TPR_7,TPR_8
CMS3_k127_1555523_1	5341.XP_007330371.1	6.248e-13	72.0	COG1048@1|root,KOG0453@2759|Eukaryota,38FZD@33154|Opisthokonta,3NUC6@4751|Fungi,3UXT3@5204|Basidiomycota,22BTY@155619|Agaricomycetes,3W465@5338|Agaricales	4751|Fungi	E	Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis	LYS4	GO:0003674,GO:0003824,GO:0004409,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006536,GO:0006553,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009066,GO:0009067,GO:0009085,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019725,GO:0019752,GO:0019878,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0098771,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.36	ko:K01705	ko00300,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map01100,map01120,map01130,map01210,map01230	M00030,M00433	R04371	RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
CMS3_k127_1555523_3	880073.Calab_2081	0.0002978	51.0	COG3291@1|root,COG5276@1|root,COG3291@2|Bacteria,COG5276@2|Bacteria,2NQ2P@2323|unclassified Bacteria	2|Bacteria	P	LVIVD repeat	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	LVIVD
CMS3_k127_1555523_2	314264.ROS217_13711	1.427e-11	75.0	COG2067@1|root,COG2067@2|Bacteria,1REWT@1224|Proteobacteria,2TXXB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1555523_0	587753.EY04_14590	4.543e-47	176.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	ubiE_2	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS3_k127_1564573_1	945713.IALB_2994	9.223e-08	64.0	28P4Q@1|root,2ZBZV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1564573_0	378806.STAUR_1517	2.022e-54	199.0	COG1028@1|root,COG1028@2|Bacteria,1RA3U@1224|Proteobacteria,42TV0@68525|delta/epsilon subdivisions,2WR1B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS3_k127_1597838_1	713586.KB900536_gene2414	2.922e-104	345.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
CMS3_k127_1597838_2	945713.IALB_0461	6.91e-103	359.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	aprN	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS3_k127_1597838_3	459349.CLOAM0192	5.371e-09	69.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	Autotransporter,FlgD_ig,PKD
CMS3_k127_1597838_0	518766.Rmar_1199	9.354e-147	475.0	COG0001@1|root,COG0001@2|Bacteria,4NDXG@976|Bacteroidetes,1FIZB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_1600304_0	1379698.RBG1_1C00001G1659	6.208e-34	132.0	COG2812@1|root,COG2812@2|Bacteria,2NNK7@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
CMS3_k127_1608494_1	1380356.JNIK01000011_gene1933	5.534e-32	130.0	COG1610@1|root,COG1610@2|Bacteria,2IFFJ@201174|Actinobacteria,4ET0X@85013|Frankiales	201174|Actinobacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
CMS3_k127_1608494_2	742725.HMPREF9450_00129	2.728e-05	55.0	COG1286@1|root,COG1286@2|Bacteria	2|Bacteria	S	toxin biosynthetic process	cvpA	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
CMS3_k127_1608494_0	1009370.ALO_18200	2.898e-47	190.0	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,4H2Z9@909932|Negativicutes	909932|Negativicutes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
CMS3_k127_1652535_0	1379698.RBG1_1C00001G1080	1.378e-180	592.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS3_k127_1654462_0	643648.Slip_0054	9.456e-159	515.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,42JKJ@68298|Syntrophomonadaceae	186801|Clostridia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
CMS3_k127_1654462_2	1379698.RBG1_1C00001G0316	1.106e-33	147.0	COG2812@1|root,COG2812@2|Bacteria,2NPH0@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
CMS3_k127_1654462_1	592015.HMPREF1705_01218	5.418e-48	184.0	COG4942@1|root,COG4942@2|Bacteria,3T9S7@508458|Synergistetes	508458|Synergistetes	D	Peptidase, M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
CMS3_k127_167958_0	1499967.BAYZ01000008_gene5423	4.021e-66	241.0	COG5000@1|root,COG5000@2|Bacteria,2NQRV@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	ntrY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
CMS3_k127_167958_1	1123008.KB905694_gene1719	1.915e-59	217.0	COG0500@1|root,COG2226@2|Bacteria,4NEUC@976|Bacteroidetes,2FPEJ@200643|Bacteroidia,22YY7@171551|Porphyromonadaceae	976|Bacteroidetes	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	arsM	-	2.1.1.137,2.1.1.79	ko:K00574,ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_31
CMS3_k127_167958_2	880073.Calab_3278	4.055e-46	181.0	COG3049@1|root,COG3049@2|Bacteria	2|Bacteria	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
CMS3_k127_1724473_5	932678.THERU_06115	1.814e-33	134.0	COG0044@1|root,COG0044@2|Bacteria,2G3JH@200783|Aquificae	200783|Aquificae	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
CMS3_k127_1724473_0	1379270.AUXF01000005_gene770	5.476e-117	390.0	COG0540@1|root,COG0540@2|Bacteria,1ZSN7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS3_k127_1724473_1	264732.Moth_0878	2.072e-70	244.0	COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,24FQD@186801|Clostridia,42G0W@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family. PyrR subfamily	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	iHN637.CLJU_RS05275	Pribosyltran
CMS3_k127_1724473_3	686340.Metal_3269	1.718e-50	189.0	COG4122@1|root,COG4122@2|Bacteria,1RHWY@1224|Proteobacteria	1224|Proteobacteria	Q	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
CMS3_k127_1724473_4	1304880.JAGB01000003_gene1181	5.456e-48	188.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	cbiO	-	-	ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
CMS3_k127_1724473_2	867903.ThesuDRAFT_00588	3.151e-51	194.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,3WCG3@538999|Clostridiales incertae sedis	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfA	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
CMS3_k127_1752890_3	391625.PPSIR1_24914	7.137e-49	192.0	COG0515@1|root,COG0515@2|Bacteria	391625.PPSIR1_24914|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1752890_5	457398.HMPREF0326_01605	6.089e-13	78.0	COG2839@1|root,COG2839@2|Bacteria,1N4E0@1224|Proteobacteria,42TWS@68525|delta/epsilon subdivisions,2WQX4@28221|Deltaproteobacteria,2MB9W@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF456)	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
CMS3_k127_1752890_1	314345.SPV1_05332	9.111e-62	235.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria	1224|Proteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
CMS3_k127_1752890_0	1379698.RBG1_1C00001G0345	4.065e-108	373.0	COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
CMS3_k127_1752890_4	1125863.JAFN01000001_gene392	7.077e-45	178.0	COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,42RJN@68525|delta/epsilon subdivisions,2WNEI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Divergent polysaccharide deacetylase	yibQ	-	-	ko:K09798	-	-	-	-	ko00000	-	-	-	Polysacc_deac_2
CMS3_k127_1752890_6	518766.Rmar_0713	7.374e-10	69.0	2EGU2@1|root,33AK8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1752890_2	290397.Adeh_3685	2.725e-51	194.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,42QAC@68525|delta/epsilon subdivisions,2WN8H@28221|Deltaproteobacteria,2Z0N2@29|Myxococcales	28221|Deltaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
CMS3_k127_1753456_0	1128421.JAGA01000003_gene2811	5.36e-131	429.0	COG0498@1|root,COG0498@2|Bacteria,2NP42@2323|unclassified Bacteria	2|Bacteria	E	Threonine synthase	MA20_41710	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_1753456_1	204669.Acid345_0631	2.837e-30	125.0	COG2905@1|root,COG2905@2|Bacteria,3Y5NG@57723|Acidobacteria,2JN0N@204432|Acidobacteriia	204432|Acidobacteriia	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS3_k127_1790429_1	1122194.AUHU01000014_gene1221	2.781e-38	153.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,1S38U@1236|Gammaproteobacteria,466VG@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG1512 Beta-propeller domains of methanol dehydrogenase type	Z012_08980	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
CMS3_k127_1790429_0	1191523.MROS_0414	8.39e-53	194.0	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
CMS3_k127_1790429_2	1254432.SCE1572_09015	6.083e-24	107.0	COG4276@1|root,COG4276@2|Bacteria,1R0BS@1224|Proteobacteria,43CU7@68525|delta/epsilon subdivisions,2X81U@28221|Deltaproteobacteria,2Z3JC@29|Myxococcales	28221|Deltaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
CMS3_k127_179045_1	316274.Haur_0787	2.944e-55	207.0	COG1187@1|root,COG1187@2|Bacteria,2G6HU@200795|Chloroflexi,375DQ@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS3_k127_179045_0	1410617.JHXH01000008_gene2147	9.853e-60	226.0	COG0204@1|root,COG0283@1|root,COG0204@2|Bacteria,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,24HEF@186801|Clostridia,3WIDU@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
CMS3_k127_1801549_0	1089553.Tph_c12530	1.641e-07	64.0	COG2234@1|root,COG2234@2|Bacteria,1V13T@1239|Firmicutes,24A8F@186801|Clostridia	186801|Clostridia	S	PFAM Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
CMS3_k127_1826107_2	290397.Adeh_1870	3.827e-09	59.0	COG1196@1|root,COG1196@2|Bacteria,1R3XQ@1224|Proteobacteria,42YF5@68525|delta/epsilon subdivisions,2WUDV@28221|Deltaproteobacteria,2YUE5@29|Myxococcales	28221|Deltaproteobacteria	D	HAD superfamily (subfamily IG) hydrolase 5'-Nucleotidase	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid
CMS3_k127_1826107_0	429009.Adeg_0526	1.522e-142	471.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,42ETH@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
CMS3_k127_1826107_1	596151.DesfrDRAFT_2898	5.848e-13	78.0	COG2755@1|root,COG2755@2|Bacteria,1NHW6@1224|Proteobacteria,42XAM@68525|delta/epsilon subdivisions,2WSXZ@28221|Deltaproteobacteria,2MDU0@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS3_k127_1832089_0	1279009.ADICEAN_01064	9.62e-82	279.0	COG4784@1|root,COG4784@2|Bacteria,4PM59@976|Bacteroidetes,47MK2@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CMS3_k127_1832089_1	1070774.J07HN4v3_02717	1.353e-31	134.0	COG3332@1|root,arCOG06429@2157|Archaea,2XU65@28890|Euryarchaeota,23UCP@183963|Halobacteria	183963|Halobacteria	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
CMS3_k127_1832089_2	926560.KE387027_gene895	5.451e-14	74.0	COG1983@1|root,COG1983@2|Bacteria,1WKSH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	KT	PspC domain	-	-	-	-	-	-	-	-	-	-	-	-	PspC
CMS3_k127_1841616_2	861299.J421_3910	2.779e-06	59.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
CMS3_k127_1841616_3	1267535.KB906767_gene1042	0.0003955	50.0	COG5662@1|root,COG5662@2|Bacteria,3Y4S0@57723|Acidobacteria	57723|Acidobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
CMS3_k127_1841616_1	880073.Calab_1183	3.081e-44	168.0	COG1595@1|root,COG1595@2|Bacteria,2NPRC@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_1841616_0	1345023.M467_12970	2.722e-90	302.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,4HAKI@91061|Bacilli,3WDYC@539002|Bacillales incertae sedis	91061|Bacilli	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
CMS3_k127_1859177_2	316278.SynRCC307_1648	6.478e-23	101.0	COG0001@1|root,COG0001@2|Bacteria,1G162@1117|Cyanobacteria,1GYKV@1129|Synechococcus	1117|Cyanobacteria	H	Glutamate-1-semialdehyde aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_1859177_0	269799.Gmet_0016	2.237e-103	347.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,42MV9@68525|delta/epsilon subdivisions,2WJZK@28221|Deltaproteobacteria,43S1P@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0016	URO-D
CMS3_k127_1859177_1	246197.MXAN_0062	6.053e-45	168.0	COG0662@1|root,COG0662@2|Bacteria,1RHWU@1224|Proteobacteria,42U1Z@68525|delta/epsilon subdivisions,2WQ05@28221|Deltaproteobacteria,2Z1RY@29|Myxococcales	28221|Deltaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS3_k127_186531_0	1569209.BBPH01000022_gene347	2.54e-109	366.0	COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,2U2EI@28211|Alphaproteobacteria,2PY78@265|Paracoccus	28211|Alphaproteobacteria	E	Thermolysin metallopeptidase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M4,Peptidase_M4_C
CMS3_k127_186531_1	1417296.U879_20655	1.053e-47	177.0	COG0010@1|root,COG0010@2|Bacteria,1N8KF@1224|Proteobacteria,2UN2I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
CMS3_k127_188480_0	1278073.MYSTI_04407	6.307e-205	666.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2YVB7@29|Myxococcales	28221|Deltaproteobacteria	J	Amidase	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS3_k127_188480_1	861299.J421_2387	7.329e-26	125.0	COG1680@1|root,COG1680@2|Bacteria,1ZV34@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_1919829_0	641524.ADICYQ_1863	2.446e-88	297.0	COG2225@1|root,COG2225@2|Bacteria,4NF5H@976|Bacteroidetes,47JKU@768503|Cytophagia	976|Bacteroidetes	C	Malate synthase	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
CMS3_k127_1919829_1	1122963.AUHB01000011_gene1315	1.879e-72	257.0	COG1680@1|root,COG1680@2|Bacteria,1PDR2@1224|Proteobacteria,2U487@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_1922691_1	710111.FraQA3DRAFT_5393	5.219e-42	160.0	COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,4ESK5@85013|Frankiales	201174|Actinobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
CMS3_k127_1922691_4	136273.GY22_04885	5.371e-18	88.0	COG0360@1|root,COG0360@2|Bacteria,2IQHD@201174|Actinobacteria,1W9TM@1268|Micrococcaceae	201174|Actinobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
CMS3_k127_1922691_3	1235835.C814_01371	3.372e-23	100.0	COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,24MQV@186801|Clostridia,3WJU7@541000|Ruminococcaceae	186801|Clostridia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
CMS3_k127_1922691_2	1123376.AUIU01000011_gene1050	3.343e-28	124.0	COG0359@1|root,COG0359@2|Bacteria,3J0MQ@40117|Nitrospirae	40117|Nitrospirae	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
CMS3_k127_1922691_0	373903.Hore_22860	2.765e-93	317.0	COG0836@1|root,COG0836@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia,3WAC4@53433|Halanaerobiales	186801|Clostridia	M	PFAM Nucleotidyl transferase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
CMS3_k127_1922691_5	551789.ATVJ01000001_gene1784	9.957e-10	71.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2TVQD@28211|Alphaproteobacteria,43XE3@69657|Hyphomonadaceae	28211|Alphaproteobacteria	O	Peptidylprolyl isomerase	prsA	-	5.2.1.8	ko:K01802,ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3
CMS3_k127_1934576_0	290397.Adeh_3068	1.152e-44	173.0	COG3005@1|root,COG3005@2|Bacteria,1QYGG@1224|Proteobacteria,42NFU@68525|delta/epsilon subdivisions,2WKHN@28221|Deltaproteobacteria,2Z2AP@29|Myxococcales	28221|Deltaproteobacteria	C	Class III cytochrome C family	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
CMS3_k127_1934576_2	290397.Adeh_3070	2.74e-11	73.0	2EUMZ@1|root,33N3U@2|Bacteria,1NUNW@1224|Proteobacteria,42ZFD@68525|delta/epsilon subdivisions,2WV00@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_1934576_1	243231.GSU2498	1.098e-17	90.0	COG4380@1|root,COG4380@2|Bacteria,1NJYS@1224|Proteobacteria,42X1E@68525|delta/epsilon subdivisions,2WTEE@28221|Deltaproteobacteria,43VPV@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Putative bacterial lipoprotein (DUF799)	-	-	-	-	-	-	-	-	-	-	-	-	DUF799
CMS3_k127_1946067_1	1265313.HRUBRA_00543	2.487e-09	68.0	COG0457@1|root,COG4976@1|root,COG0457@2|Bacteria,COG4976@2|Bacteria,1RAIT@1224|Proteobacteria,1S6MW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	methyltransferase	yrrB	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31,TPR_1,TPR_16,TPR_2,TPR_4,TPR_7,TPR_8
CMS3_k127_1946067_0	479434.Sthe_1246	4.788e-37	160.0	COG0515@1|root,COG1520@1|root,COG0515@2|Bacteria,COG1520@2|Bacteria,2G5NM@200795|Chloroflexi,27Z13@189775|Thermomicrobia	189775|Thermomicrobia	KLT	PQQ-like domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PQQ_3,Pkinase
CMS3_k127_1948500_0	880072.Desac_1035	3.912e-38	164.0	COG0067@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0070@2|Bacteria,1NZ4D@1224|Proteobacteria,43B3T@68525|delta/epsilon subdivisions,2X6HR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	GXGXG motif	-	-	-	-	-	-	-	-	-	-	-	-	GATase_6,GXGXG
CMS3_k127_1948500_1	1158756.AQXQ01000011_gene718	5.486e-07	57.0	COG0394@1|root,COG3919@1|root,COG0394@2|Bacteria,COG3919@2|Bacteria,1R94Z@1224|Proteobacteria,1RQ74@1236|Gammaproteobacteria,1WZV0@135613|Chromatiales	135613|Chromatiales	T	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	LMWPc
CMS3_k127_1960504_0	365044.Pnap_0437	6.957e-16	84.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,4AA9F@80864|Comamonadaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,Response_reg,dCache_1
CMS3_k127_196915_1	1094980.Mpsy_1210	5.611e-42	158.0	COG2426@1|root,arCOG01330@2157|Archaea,2XZ2Y@28890|Euryarchaeota,2NAQX@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
CMS3_k127_196915_0	329726.AM1_3472	6.001e-170	546.0	COG0591@1|root,COG0591@2|Bacteria,1G3Y2@1117|Cyanobacteria	1117|Cyanobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS3_k127_196915_2	215803.DB30_1330	6.431e-32	132.0	COG0546@1|root,COG0546@2|Bacteria,1Q3MM@1224|Proteobacteria,439F0@68525|delta/epsilon subdivisions,2X4Q9@28221|Deltaproteobacteria,2YZDY@29|Myxococcales	28221|Deltaproteobacteria	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS3_k127_1975737_3	1304874.JAFY01000002_gene95	9.971e-05	50.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3TAX3@508458|Synergistetes	508458|Synergistetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_16
CMS3_k127_1975737_2	65672.G4TFE9	3.749e-06	59.0	COG2234@1|root,KOG2194@2759|Eukaryota,38F29@33154|Opisthokonta,3NV70@4751|Fungi,3V48J@5204|Basidiomycota,227M3@155619|Agaricomycetes,3H2PZ@355688|Agaricomycetes incertae sedis	4751|Fungi	O	Peptidase family M28	-	GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0030163,GO:0031090,GO:0031224,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0098588,GO:0098805,GO:0098852,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K13095	-	-	-	-	ko00000,ko03041	-	-	-	Peptidase_M28
CMS3_k127_1975737_1	1178540.BA70_11820	1.165e-06	58.0	COG0454@1|root,COG0456@2|Bacteria,1VAU8@1239|Firmicutes,4HMA6@91061|Bacilli,1ZFP4@1386|Bacillus	91061|Bacilli	K	Acetyltransferase	yycN	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_1975737_0	1177928.TH2_13919	1.446e-63	239.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,2JPK4@204441|Rhodospirillales	204441|Rhodospirillales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	ntrC	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_1991211_0	935836.JAEL01000080_gene76	2.438e-09	70.0	COG2234@1|root,COG2234@2|Bacteria,1UFM1@1239|Firmicutes,4HBE5@91061|Bacilli,1ZC0A@1386|Bacillus	91061|Bacilli	S	PA domain	-	-	3.4.11.10,3.4.11.6	ko:K19701	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28
CMS3_k127_1993129_2	1123371.ATXH01000006_gene840	2.897e-91	316.0	COG0536@1|root,COG0536@2|Bacteria,2GHPW@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
CMS3_k127_1993129_1	867903.ThesuDRAFT_02205	2.067e-93	327.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,3WCM1@538999|Clostridiales incertae sedis	186801|Clostridia	E	Aminotransferase class I and II	aspB	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	iHN637.CLJU_RS06550	Aminotran_1_2
CMS3_k127_1993129_3	1121015.N789_02650	1.846e-44	171.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1X5VI@135614|Xanthomonadales	135614|Xanthomonadales	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
CMS3_k127_1993129_4	1442599.JAAN01000036_gene530	1.198e-32	134.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,1X6P7@135614|Xanthomonadales	135614|Xanthomonadales	L	Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
CMS3_k127_1993129_5	1385514.N782_08545	9.976e-24	113.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,4HKD6@91061|Bacilli,2YANB@289201|Pontibacillus	91061|Bacilli	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
CMS3_k127_1993129_0	264732.Moth_1557	2.204e-124	410.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,42F8N@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
CMS3_k127_1997300_0	1379698.RBG1_1C00001G0659	5.106e-89	297.0	COG0178@1|root,COG0178@2|Bacteria,2NNT3@2323|unclassified Bacteria	2|Bacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS3_k127_1997300_1	309801.trd_A0811	2.028e-61	220.0	COG1032@1|root,COG1032@2|Bacteria,2G7MA@200795|Chloroflexi,27Y05@189775|Thermomicrobia	189775|Thermomicrobia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS3_k127_2022267_4	926569.ANT_17840	4.934e-23	110.0	COG0375@1|root,COG0375@2|Bacteria,2G7H5@200795|Chloroflexi	200795|Chloroflexi	C	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
CMS3_k127_2022267_2	926569.ANT_17850	2.362e-75	260.0	COG0378@1|root,COG0378@2|Bacteria,2G6EP@200795|Chloroflexi	200795|Chloroflexi	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K03189,ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
CMS3_k127_2022267_0	926569.ANT_17860	5.894e-232	743.0	COG0068@1|root,COG0068@2|Bacteria,2G5QN@200795|Chloroflexi	200795|Chloroflexi	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
CMS3_k127_2022267_3	926550.CLDAP_24420	3.207e-26	114.0	COG0298@1|root,COG0298@2|Bacteria,2G7GW@200795|Chloroflexi	200795|Chloroflexi	O	PFAM hydrogenase expression formation protein (HUPF HYPC)	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
CMS3_k127_2022267_1	1206744.BAGL01000128_gene6782	2.472e-114	373.0	COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria,4FVKR@85025|Nocardiaceae	201174|Actinobacteria	O	Hydrogenase formation hypA family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
CMS3_k127_2024966_0	290397.Adeh_0259	2.022e-114	375.0	COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,42P03@68525|delta/epsilon subdivisions,2WIPY@28221|Deltaproteobacteria,2YUA4@29|Myxococcales	28221|Deltaproteobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
CMS3_k127_2024966_1	1094508.Tsac_2168	1.416e-50	183.0	COG2185@1|root,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,24HAR@186801|Clostridia,42GHH@68295|Thermoanaerobacterales	186801|Clostridia	I	methylmalonyl-CoA mutase C-terminal	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
CMS3_k127_2024966_2	536019.Mesop_0175	3.274e-47	176.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,43JRE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
CMS3_k127_2024966_3	13690.CP98_04528	3.83e-36	151.0	COG0500@1|root,COG0726@1|root,COG1215@1|root,COG0500@2|Bacteria,COG0726@2|Bacteria,COG1215@2|Bacteria,1RIMV@1224|Proteobacteria,2TW81@28211|Alphaproteobacteria,2KECZ@204457|Sphingomonadales	204457|Sphingomonadales	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	NodS
CMS3_k127_2024966_4	1379698.RBG1_1C00001G1024	4.094e-16	89.0	COG0382@1|root,COG0382@2|Bacteria,2NRJ9@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	-	-	2.5.1.133,2.5.1.39,2.5.1.62	ko:K03179,ko:K04040	ko00130,ko00860,ko01100,ko01110,map00130,map00860,map01100,map01110	M00117	R05000,R05615,R06284,R09067,R11514,R11517	RC00020,RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
CMS3_k127_2032589_1	330214.NIDE4162	2.184e-66	234.0	COG0177@1|root,COG0177@2|Bacteria,3J0K6@40117|Nitrospirae	2|Bacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.2,4.2.99.18	ko:K01142,ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
CMS3_k127_2032589_4	1121930.AQXG01000001_gene1251	3.566e-11	72.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS3_k127_2032589_2	870187.Thini_0382	3.627e-29	129.0	COG3695@1|root,COG3695@2|Bacteria,1N7J2@1224|Proteobacteria,1SCIZ@1236|Gammaproteobacteria,463F1@72273|Thiotrichales	72273|Thiotrichales	L	PFAM 6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
CMS3_k127_2032589_3	709991.Odosp_2650	2.078e-14	80.0	COG2832@1|root,COG2832@2|Bacteria,4NS6H@976|Bacteroidetes,2FSGM@200643|Bacteroidia,22YP7@171551|Porphyromonadaceae	976|Bacteroidetes	S	Protein of unknown function (DUF454)	-	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
CMS3_k127_2032589_0	395961.Cyan7425_2945	3.568e-98	326.0	COG2020@1|root,COG2020@2|Bacteria,1G4HN@1117|Cyanobacteria,3KGIV@43988|Cyanothece	1117|Cyanobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU,PEMT
CMS3_k127_2040568_7	1051632.TPY_1218	3.804e-05	53.0	COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,24QME@186801|Clostridia,3WCPE@538999|Clostridiales incertae sedis	186801|Clostridia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CMS3_k127_2040568_5	1089552.KI911559_gene1529	2.688e-30	135.0	COG1024@1|root,COG1024@2|Bacteria,1PEX7@1224|Proteobacteria,2V7VI@28211|Alphaproteobacteria,2JWT1@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
CMS3_k127_2040568_3	319225.Plut_0972	1.185e-55	224.0	COG1022@1|root,COG1022@2|Bacteria,1FDU1@1090|Chlorobi	1090|Chlorobi	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
CMS3_k127_2040568_0	1123242.JH636435_gene2291	5.164e-126	418.0	COG2327@1|root,COG2327@2|Bacteria	2|Bacteria	S	slime layer polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
CMS3_k127_2040568_4	469383.Cwoe_4933	4.297e-31	143.0	COG3320@1|root,COG3320@2|Bacteria,2I9YC@201174|Actinobacteria	201174|Actinobacteria	Q	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4
CMS3_k127_2040568_2	502025.Hoch_3248	3.547e-89	323.0	COG0204@1|root,COG0236@1|root,COG1022@1|root,COG3320@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG1022@2|Bacteria,COG3320@2|Bacteria,1MU4D@1224|Proteobacteria,42NHQ@68525|delta/epsilon subdivisions,2WJZ5@28221|Deltaproteobacteria,2YU6Q@29|Myxococcales	28221|Deltaproteobacteria	IQ	Male sterility protein	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,NAD_binding_4,PP-binding,Sterile
CMS3_k127_2040568_6	502025.Hoch_3628	9.624e-12	79.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,42TQ7@68525|delta/epsilon subdivisions,2WS2Q@28221|Deltaproteobacteria,2Z36A@29|Myxococcales	28221|Deltaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
CMS3_k127_2040568_1	62928.azo0832	1.577e-100	340.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2VKXU@28216|Betaproteobacteria,2KVSV@206389|Rhodocyclales	206389|Rhodocyclales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_2054734_3	1223523.H340_17487	1.207e-23	100.0	COG1834@1|root,COG1834@2|Bacteria,2H33J@201174|Actinobacteria	201174|Actinobacteria	E	N-dimethylarginine dimethylaminohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
CMS3_k127_2054734_0	1235788.C802_02607	3.483e-72	260.0	COG0534@1|root,COG0534@2|Bacteria,4NFIR@976|Bacteroidetes,2FMSA@200643|Bacteroidia,4AN4V@815|Bacteroidaceae	976|Bacteroidetes	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS3_k127_2054734_2	1267534.KB906755_gene4691	1.621e-60	218.0	COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria	57723|Acidobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_2054734_1	1267534.KB906755_gene4692	8.801e-69	256.0	COG0642@1|root,COG2205@2|Bacteria	1267534.KB906755_gene4692|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2056402_1	1192034.CAP_7000	4.119e-07	54.0	COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria,2YUHN@29|Myxococcales	28221|Deltaproteobacteria	L	Domain of unknown function (DUF1998)	yprA	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C,RNase_H_2
CMS3_k127_2056402_0	243231.GSU3318	8.546e-114	383.0	COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,42QA4@68525|delta/epsilon subdivisions,2WKD1@28221|Deltaproteobacteria,43SDE@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
CMS3_k127_2059503_1	1123274.KB899414_gene3603	3.407e-15	78.0	COG0574@1|root,COG0784@1|root,COG2197@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria,COG2197@2|Bacteria	2|Bacteria	K	response regulator	ppsA	-	2.7.9.2	ko:K01007,ko:K07699	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02020,ko02024,map00620,map00680,map00720,map01100,map01120,map01200,map02020,map02024	M00173,M00374,M00485	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	PPDK_N,Response_reg,SpoIIE
CMS3_k127_2059503_0	1191523.MROS_2800	1.795e-213	679.0	COG0334@1|root,COG0334@2|Bacteria	2|Bacteria	E	glutamate dehydrogenase [NAD(P)+] activity	gluD	GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.2,1.4.1.3,1.4.1.4	ko:K00260,ko:K00261,ko:K00262	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.gdhA	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_2059503_2	489825.LYNGBM3L_67650	1.213e-13	82.0	COG0457@1|root,COG1216@1|root,COG3914@1|root,COG0457@2|Bacteria,COG1216@2|Bacteria,COG3914@2|Bacteria,1G0YS@1117|Cyanobacteria,1H82I@1150|Oscillatoriales	1117|Cyanobacteria	O	O-linked N-acetylglucosamine transferase SPINDLY family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,Sulfotransfer_2,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
CMS3_k127_2060654_0	321327.CYA_2808	5.657e-152	492.0	COG0277@1|root,COG0277@2|Bacteria,1G1U2@1117|Cyanobacteria,1GZG1@1129|Synechococcus	1117|Cyanobacteria	C	Glycolate oxidase subunit GlcD	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
CMS3_k127_2060654_1	1449346.JQMO01000003_gene2678	3.333e-28	126.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_206237_0	240015.ACP_0050	4.846e-145	467.0	COG0567@1|root,COG0567@2|Bacteria,3Y3EF@57723|Acidobacteria,2JICX@204432|Acidobacteriia	204432|Acidobacteriia	C	2-oxoglutarate dehydrogenase, E1	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,OxoGdeHyase_C,Transket_pyr
CMS3_k127_206237_1	1305737.JAFX01000001_gene2200	1.761e-31	140.0	COG5276@1|root,COG5276@2|Bacteria,4NIBK@976|Bacteroidetes,47TH3@768503|Cytophagia	976|Bacteroidetes	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
CMS3_k127_2069125_0	101510.RHA1_ro11226	2.176e-117	395.0	COG0437@1|root,COG5557@1|root,COG0437@2|Bacteria,COG5557@2|Bacteria,2H0W0@201174|Actinobacteria,4G8WN@85025|Nocardiaceae	201174|Actinobacteria	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_3,Fer4_4,Fer4_7,NrfD
CMS3_k127_2069125_1	391625.PPSIR1_23459	1.276e-82	286.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2WJ43@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS3_k127_2084444_1	1232410.KI421413_gene670	1.847e-24	113.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,42V1F@68525|delta/epsilon subdivisions,2WR79@28221|Deltaproteobacteria,43SR6@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
CMS3_k127_2084444_0	194439.CT0092	7.591e-92	311.0	COG0240@1|root,COG0240@2|Bacteria,1FDCM@1090|Chlorobi	1090|Chlorobi	I	NAD-dependent glycerol-3-phosphate dehydrogenase domain protein	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
CMS3_k127_2086319_1	909663.KI867150_gene889	5.972e-07	53.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,42QXH@68525|delta/epsilon subdivisions,2WMN3@28221|Deltaproteobacteria,2MQP4@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	SurA N-terminal domain	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
CMS3_k127_2086319_0	234267.Acid_1726	6.772e-115	394.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
CMS3_k127_2105653_4	1380347.JNII01000011_gene862	6.417e-16	91.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4ERPN@85013|Frankiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_2105653_1	324602.Caur_3360	6.133e-29	134.0	COG0483@1|root,COG0483@2|Bacteria,2G92C@200795|Chloroflexi,375IY@32061|Chloroflexia	32061|Chloroflexia	G	PFAM inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
CMS3_k127_2105653_0	204669.Acid345_3902	1.863e-79	275.0	COG0123@1|root,COG0123@2|Bacteria,3Y46F@57723|Acidobacteria,2JMK7@204432|Acidobacteriia	204432|Acidobacteriia	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
CMS3_k127_2105653_2	1395516.PMO01_19945	8.572e-19	101.0	COG0624@1|root,COG0624@2|Bacteria,1R44A@1224|Proteobacteria,1RZ9X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Dipeptidase	pepV	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_2105653_3	1051632.TPY_3574	1.14e-18	89.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,3WCGV@538999|Clostridiales incertae sedis	186801|Clostridia	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
CMS3_k127_2152682_3	264462.Bd1723	1.825e-30	130.0	COG0142@1|root,COG0142@2|Bacteria,1NXYK@1224|Proteobacteria,430UK@68525|delta/epsilon subdivisions,2WVY1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Belongs to the FPP GGPP synthase family	-	-	-	-	-	-	-	-	-	-	-	-	polyprenyl_synt
CMS3_k127_2152682_0	502025.Hoch_2211	1.374e-235	737.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,43BX1@68525|delta/epsilon subdivisions,2X77U@28221|Deltaproteobacteria,2YTZ8@29|Myxococcales	28221|Deltaproteobacteria	Q	Phytoene dehydrogenase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
CMS3_k127_2152682_1	502025.Hoch_2212	5.676e-91	312.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,430A5@68525|delta/epsilon subdivisions,2WVA4@28221|Deltaproteobacteria,2Z1CK@29|Myxococcales	28221|Deltaproteobacteria	I	PFAM Squalene phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
CMS3_k127_2152682_4	1048983.EL17_17105	1.349e-19	97.0	COG4704@1|root,COG4704@2|Bacteria,4NUS8@976|Bacteroidetes,47S7U@768503|Cytophagia	976|Bacteroidetes	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2141
CMS3_k127_2152682_2	502025.Hoch_2161	8.501e-90	302.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	crtT	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Ubie_methyltran
CMS3_k127_2152682_5	1114959.SZMC14600_00125	2.842e-16	90.0	COG3349@1|root,COG3349@2|Bacteria,2GITE@201174|Actinobacteria,4DX5N@85010|Pseudonocardiales	201174|Actinobacteria	Q	PFAM Flavin containing amine oxidoreductase	crtU	-	-	ko:K09879	ko00906,map00906	-	R07541,R07560,R07857,R07858	RC01901,RC01965	ko00000,ko00001	-	-	-	Amino_oxidase
CMS3_k127_2156773_0	344747.PM8797T_00899	1.98e-188	604.0	COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes	203682|Planctomycetes	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
CMS3_k127_2156773_1	768671.ThimaDRAFT_0364	4.623e-169	562.0	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,1RNUM@1236|Gammaproteobacteria,1WW3E@135613|Chromatiales	135613|Chromatiales	S	Deoxyribodipyrimidine photo-lyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
CMS3_k127_2159318_1	997884.HMPREF1068_01427	2.278e-31	136.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Cna_B,Cu_amine_oxidN1,PSII_BNR,SLH
CMS3_k127_2159318_0	1121878.AUGL01000002_gene2296	5.436e-39	151.0	2A42S@1|root,30SMP@2|Bacteria,1RFZA@1224|Proteobacteria	1224|Proteobacteria	S	Nickel-containing superoxide dismutase	-	-	1.15.1.1	ko:K00518	-	-	-	-	ko00000,ko01000	-	-	-	Sod_Ni
CMS3_k127_2159318_2	765420.OSCT_1275	6.348e-26	123.0	COG1807@1|root,COG1807@2|Bacteria,2G8IK@200795|Chloroflexi,375EI@32061|Chloroflexia	32061|Chloroflexia	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2160458_0	221109.22778124	2.783e-137	445.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,4H9NS@91061|Bacilli,23JRD@182709|Oceanobacillus	91061|Bacilli	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
CMS3_k127_2160458_1	264732.Moth_0225	5.969e-21	103.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,42FNR@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM Phosphoribosyltransferase	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
CMS3_k127_2160458_2	1094980.Mpsy_1421	3.802e-15	76.0	COG0169@1|root,arCOG01033@2157|Archaea,2XV7K@28890|Euryarchaeota,2N9IF@224756|Methanomicrobia	224756|Methanomicrobia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25,2.7.1.71,4.2.1.10	ko:K00014,ko:K00891,ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R02413,R03084	RC00002,RC00078,RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0923	SKI,Shikimate_DH,Shikimate_dh_N
CMS3_k127_2162059_1	1454004.AW11_02485	2.026e-92	305.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS3_k127_2162059_0	1454004.AW11_02484	6.647e-127	412.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
CMS3_k127_2162059_2	1232410.KI421417_gene2703	2.598e-60	217.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,42RV7@68525|delta/epsilon subdivisions,2WNZT@28221|Deltaproteobacteria,43RZE@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Kinase/pyrophosphorylase	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
CMS3_k127_2162059_3	926560.KE387023_gene2407	8.213e-25	110.0	COG1832@1|root,COG1832@2|Bacteria	2|Bacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
CMS3_k127_2174889_1	1242864.D187_001595	1.692e-05	59.0	COG0457@1|root,COG3118@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	hupG	-	-	ko:K03619,ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	BCSC_C,HyaE,TPR_16,TPR_19,TPR_8
CMS3_k127_2174889_0	685727.REQ_25410	6.119e-07	60.0	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4FUSU@85025|Nocardiaceae	201174|Actinobacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
CMS3_k127_2182551_0	483219.LILAB_04485	1.778e-20	106.0	COG0810@1|root,COG1629@1|root,COG0810@2|Bacteria,COG4771@2|Bacteria,1R5B9@1224|Proteobacteria,43C1I@68525|delta/epsilon subdivisions,2X7C6@28221|Deltaproteobacteria,2YWPC@29|Myxococcales	28221|Deltaproteobacteria	MP	Periplasmic protein TonB links inner and outer membranes	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C,TonB_dep_Rec
CMS3_k127_2182551_1	394503.Ccel_0623	0.0005241	49.0	COG4447@1|root,COG4447@2|Bacteria,1VCI4@1239|Firmicutes,24CF6@186801|Clostridia,36N4E@31979|Clostridiaceae	186801|Clostridia	M	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
CMS3_k127_2187315_1	1329516.JPST01000063_gene1783	1.975e-194	636.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,4HA6C@91061|Bacilli,27B14@186824|Thermoactinomycetaceae	91061|Bacilli	L	Bacterial DNA topoisomeraes I ATP-binding domain	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
CMS3_k127_2187315_0	1379698.RBG1_1C00001G1656	1.527e-199	640.0	COG0653@1|root,COG0653@2|Bacteria,2NNRK@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
CMS3_k127_2190804_0	497964.CfE428DRAFT_1955	4.935e-138	454.0	COG3280@1|root,COG3280@2|Bacteria,46SC6@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Alpha amylase, catalytic domain	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
CMS3_k127_2190804_1	314345.SPV1_13177	1.21e-114	379.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria	1224|Proteobacteria	M	mechanosensitive ion channel	ynaI	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
CMS3_k127_2190804_2	349161.Dred_2912	3.827e-20	91.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,260IQ@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM potassium uptake protein, TrkH family	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS3_k127_2198351_1	1232683.ADIMK_1382	2.387e-149	481.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,464PE@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.71	ko:K00128,ko:K06447	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05049,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_2198351_0	756272.Plabr_0481	1.327e-195	627.0	COG0422@1|root,COG0422@2|Bacteria,2IWV7@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
CMS3_k127_2198351_3	981383.AEWH01000029_gene664	1.572e-12	76.0	2E9CG@1|root,333K5@2|Bacteria,1V87Y@1239|Firmicutes,4HIGZ@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TIMP
CMS3_k127_2198351_2	517417.Cpar_1378	2.424e-18	91.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1FFEV@1090|Chlorobi	1090|Chlorobi	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
CMS3_k127_2198616_1	1128421.JAGA01000002_gene744	9.795e-08	59.0	COG2152@1|root,COG3291@1|root,COG2152@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PKD
CMS3_k127_2198616_0	879212.DespoDRAFT_00867	8.289e-143	480.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MIP0@213118|Desulfobacterales	68525|delta/epsilon subdivisions	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
CMS3_k127_2219534_2	479431.Namu_1685	1.911e-10	65.0	COG2259@1|root,COG2259@2|Bacteria,2IQEY@201174|Actinobacteria,4ETDJ@85013|Frankiales	201174|Actinobacteria	O	Methylamine utilisation protein MauE	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,MauE
CMS3_k127_2219534_0	1379698.RBG1_1C00001G0513	1.037e-138	457.0	COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
CMS3_k127_2219534_1	566466.NOR53_1062	3.533e-26	122.0	28MAS@1|root,318XW@2|Bacteria,1NU47@1224|Proteobacteria,1SM4U@1236|Gammaproteobacteria,1J7Z3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
CMS3_k127_2220071_1	760568.Desku_0719	2.296e-119	394.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,247NE@186801|Clostridia,26192@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS02615	GDP_Man_Dehyd
CMS3_k127_2220071_0	1278073.MYSTI_01143	2.82e-136	447.0	COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,42MSY@68525|delta/epsilon subdivisions,2WJXR@28221|Deltaproteobacteria,2YVAN@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	mnaA	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
CMS3_k127_2220071_2	1382304.JNIL01000001_gene3058	5.262e-09	59.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,4H9KT@91061|Bacilli,277YR@186823|Alicyclobacillaceae	91061|Bacilli	M	Glycosyl transferase family 4	tagO	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
CMS3_k127_2247886_0	330214.NIDE3435	5.167e-69	246.0	COG1131@1|root,COG1131@2|Bacteria,3J122@40117|Nitrospirae	40117|Nitrospirae	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_2247886_2	195253.Syn6312_2145	2.39e-31	134.0	COG1277@1|root,COG1277@2|Bacteria,1G09F@1117|Cyanobacteria,1H0C8@1129|Synechococcus	1117|Cyanobacteria	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
CMS3_k127_2247886_3	330214.NIDE3436	3.616e-09	68.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE3436|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2247886_1	1125863.JAFN01000001_gene1507	3.377e-55	205.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
CMS3_k127_2258515_2	880073.Calab_0683	8.849e-08	67.0	COG1404@1|root,COG4932@1|root,COG1404@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CarboxypepD_reg,DUF11,LRR_5,Peptidase_S8,SLH
CMS3_k127_2258515_1	880073.Calab_1374	1.774e-14	87.0	COG2067@1|root,COG2067@2|Bacteria,2NQZT@2323|unclassified Bacteria	2|Bacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2258515_0	880073.Calab_0681	1.388e-48	199.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2NP51@2323|unclassified Bacteria	2|Bacteria	KT	Sigma factor PP2C-like phosphatases	pkn5	-	2.7.11.1,3.1.3.3	ko:K04757,ko:K07315	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	AAA_16,GAF,HAMP,HATPase_c_2,Pkinase,SpoIIE,dCache_1
CMS3_k127_2264938_3	504472.Slin_1991	3.594e-12	78.0	COG0457@1|root,COG0457@2|Bacteria,4NJ1F@976|Bacteroidetes,47NCH@768503|Cytophagia	976|Bacteroidetes	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
CMS3_k127_2264938_4	1068978.AMETH_5596	7.195e-06	53.0	COG1366@1|root,COG1366@2|Bacteria,2HNQ7@201174|Actinobacteria,4E747@85010|Pseudonocardiales	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
CMS3_k127_2264938_0	1379698.RBG1_1C00001G1355	5.936e-57	214.0	COG0811@1|root,COG0811@2|Bacteria,2NPUZ@2323|unclassified Bacteria	2|Bacteria	U	MotA/TolQ/ExbB proton channel family	exbB	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
CMS3_k127_2264938_1	1379698.RBG1_1C00001G1356	1.179e-26	115.0	COG0848@1|root,COG0848@2|Bacteria	2|Bacteria	U	biopolymer transport protein	exbD1	-	-	-	-	-	-	-	-	-	-	-	ExbD
CMS3_k127_2264938_2	517417.Cpar_1513	1.207e-24	109.0	COG0848@1|root,COG0848@2|Bacteria,1FE26@1090|Chlorobi	1090|Chlorobi	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
CMS3_k127_2271281_2	404589.Anae109_0364	1.194e-28	117.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,42M39@68525|delta/epsilon subdivisions,2WJEZ@28221|Deltaproteobacteria,2YTW3@29|Myxococcales	28221|Deltaproteobacteria	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
CMS3_k127_2271281_1	1122217.KB899583_gene1248	2.8e-50	195.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,4H26F@909932|Negativicutes	909932|Negativicutes	O	PDZ DHR GLGF domain protein	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin,Trypsin_2
CMS3_k127_2271281_0	997346.HMPREF9374_3070	2.09e-53	194.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,4HACW@91061|Bacilli,27BMB@186824|Thermoactinomycetaceae	91061|Bacilli	F	Adenylosuccinate lyase C-terminus	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS09895	ADSL_C,Lyase_1
CMS3_k127_2278869_2	1379698.RBG1_1C00001G1788	5.404e-18	90.0	COG2067@1|root,COG3292@1|root,COG2067@2|Bacteria,COG3292@2|Bacteria,2NPQZ@2323|unclassified Bacteria	2|Bacteria	I	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,Reg_prop,Reprolysin_5,VCBS
CMS3_k127_2278869_1	1379698.RBG1_1C00001G1787	1.512e-54	220.0	COG1520@1|root,COG4412@1|root,COG1520@2|Bacteria,COG4412@2|Bacteria,2NPRE@2323|unclassified Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	DUF1863,PQQ_2
CMS3_k127_2278869_3	1379698.RBG1_1C00001G1786	5.534e-13	81.0	2CUTJ@1|root,32SW3@2|Bacteria,2NRD1@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2278869_4	269797.Mbar_A0416	2.076e-10	72.0	arCOG03561@1|root,arCOG03561@2157|Archaea,2Y1Q9@28890|Euryarchaeota,2N9M9@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,NHL
CMS3_k127_2278869_0	309807.SRU_1860	8.959e-61	237.0	COG5448@1|root,COG5448@2|Bacteria,4NGRS@976|Bacteroidetes,1FJ4S@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Glycoside hydrolase family 24	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2289759_1	344747.PM8797T_26780	1.136e-81	294.0	COG0642@1|root,COG2205@2|Bacteria,2J1RP@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
CMS3_k127_2289759_2	1444711.CCJF01000004_gene2434	2.713e-80	277.0	COG1090@1|root,COG1090@2|Bacteria,2JFV6@204428|Chlamydiae	204428|Chlamydiae	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
CMS3_k127_2289759_0	1279038.KB907341_gene1895	2.601e-107	357.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,2UAJA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
CMS3_k127_2289759_4	448385.sce6412	0.0009181	45.0	COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria,42NWP@68525|delta/epsilon subdivisions,2WJUA@28221|Deltaproteobacteria,2YUE6@29|Myxococcales	28221|Deltaproteobacteria	L	Deoxyribodipyrimidine photo-lyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
CMS3_k127_229966_0	1047013.AQSP01000002_gene1397	4.528e-108	361.0	COG0330@1|root,COG0330@2|Bacteria,2NP3W@2323|unclassified Bacteria	2|Bacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
CMS3_k127_229966_1	1278073.MYSTI_05633	2.086e-82	293.0	COG0249@1|root,COG0249@2|Bacteria,1N9K4@1224|Proteobacteria,42ZN5@68525|delta/epsilon subdivisions,2WUW7@28221|Deltaproteobacteria,2YTSE@29|Myxococcales	28221|Deltaproteobacteria	L	ATPase domain of DNA mismatch repair MUTS family	-	-	-	-	-	-	-	-	-	-	-	-	MutS_III,MutS_V
CMS3_k127_2301044_1	404589.Anae109_0939	1.719e-76	264.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,42U99@68525|delta/epsilon subdivisions,2WQ5W@28221|Deltaproteobacteria,2YWMR@29|Myxococcales	28221|Deltaproteobacteria	L	ATP dependent DNA ligase domain protein	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
CMS3_k127_2301044_0	404589.Anae109_0938	8.71e-86	293.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YWME@29|Myxococcales	28221|Deltaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
CMS3_k127_2301044_2	404589.Anae109_0937	4.782e-65	233.0	COG0457@1|root,COG0457@2|Bacteria,1N4HS@1224|Proteobacteria,43753@68525|delta/epsilon subdivisions,2X219@28221|Deltaproteobacteria,2Z10F@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11
CMS3_k127_2314447_2	1408473.JHXO01000015_gene1906	1.189e-25	113.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	nanA	GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Gram_pos_anchor,Sialidase,YSIRK_signal
CMS3_k127_2314447_1	1121920.AUAU01000002_gene1987	1.839e-56	202.0	COG2080@1|root,COG2080@2|Bacteria,3Y4U1@57723|Acidobacteria	57723|Acidobacteria	C	2Fe-2S -binding domain protein	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CMS3_k127_2314447_0	1121920.AUAU01000002_gene1986	2.759e-144	486.0	COG1529@1|root,COG1529@2|Bacteria,3Y35Q@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
CMS3_k127_2315776_2	1035193.HMPREF9073_01396	1.303e-15	85.0	COG2227@1|root,COG2227@2|Bacteria,4NM91@976|Bacteroidetes,1HZAR@117743|Flavobacteriia,1EQN2@1016|Capnocytophaga	976|Bacteroidetes	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2315776_1	378806.STAUR_4666	3.703e-66	233.0	COG0321@1|root,COG1051@1|root,COG0321@2|Bacteria,COG1051@2|Bacteria,1MU6A@1224|Proteobacteria,42RIC@68525|delta/epsilon subdivisions,2WPRF@28221|Deltaproteobacteria,2YVCE@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,NUDIX
CMS3_k127_2315776_0	1121920.AUAU01000004_gene789	4.715e-122	406.0	COG0508@1|root,COG0508@2|Bacteria,3Y3CV@57723|Acidobacteria	57723|Acidobacteria	C	e3 binding domain	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CMS3_k127_2315776_3	247490.KSU1_C1364	1.699e-10	62.0	COG0022@1|root,COG0022@2|Bacteria,2IYRX@203682|Planctomycetes	203682|Planctomycetes	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
CMS3_k127_2318372_0	518766.Rmar_0288	2.339e-52	210.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,4NI98@976|Bacteroidetes	976|Bacteroidetes	KT	Serine phosphatase RsbU regulator of sigma subunit	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
CMS3_k127_2318372_2	1395513.P343_01110	1.027e-22	103.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,4HH04@91061|Bacilli,26P0C@186821|Sporolactobacillaceae	91061|Bacilli	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
CMS3_k127_2318372_1	861299.J421_2620	1.831e-46	181.0	COG1559@1|root,COG1559@2|Bacteria,1ZTA7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
CMS3_k127_2324537_0	1469245.JFBG01000013_gene1935	4.185e-213	667.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,1RNFN@1236|Gammaproteobacteria,1WZY2@135613|Chromatiales	135613|Chromatiales	C	Aldehyde dehydrogenase family	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_2324537_2	1047013.AQSP01000097_gene1952	9.571e-08	64.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,TolB_like
CMS3_k127_2324537_1	370438.PTH_1876	9.293e-66	234.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,2607W@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
CMS3_k127_2331965_1	926550.CLDAP_20960	2.596e-61	238.0	COG0647@1|root,COG0647@2|Bacteria,2G6G5@200795|Chloroflexi	200795|Chloroflexi	G	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.1.3.41	ko:K01101,ko:K02566	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
CMS3_k127_2331965_0	373903.Hore_14820	6.142e-188	598.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,3WB84@53433|Halanaerobiales	186801|Clostridia	H	Belongs to the UbiD family	-	-	4.1.1.61,4.1.1.98	ko:K03182,ko:K16239	ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120	M00117	R01238,R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
CMS3_k127_2331965_2	933262.AXAM01000041_gene1891	9.398e-07	60.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,42P2Z@68525|delta/epsilon subdivisions,2WNJ6@28221|Deltaproteobacteria,2MJ9N@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
CMS3_k127_2343667_0	1122176.KB903576_gene4938	1.201e-10	76.0	COG1572@1|root,COG1572@2|Bacteria,4NDY7@976|Bacteroidetes,1IW9T@117747|Sphingobacteriia	976|Bacteroidetes	S	Peptidase family C25	porU	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
CMS3_k127_234752_0	945713.IALB_0639	6.369e-174	570.0	COG0532@1|root,COG0532@2|Bacteria	2|Bacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
CMS3_k127_234752_2	671143.DAMO_0572	1.68e-05	51.0	COG1358@1|root,COG1358@2|Bacteria	2|Bacteria	J	ncRNA processing	ylxRQ	-	-	ko:K07590,ko:K07742	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	DUF448,Ribosomal_L7Ae
CMS3_k127_234752_1	1187851.A33M_0732	7.007e-40	158.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,3FCQ9@34008|Rhodovulum	28211|Alphaproteobacteria	J	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
CMS3_k127_2358235_2	1209984.BN978_03096	2.185e-101	353.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,236M2@1762|Mycobacteriaceae	201174|Actinobacteria	E	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system	ugpC	-	3.6.3.20	ko:K05816	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1.3	-	-	ABC_tran,TOBE_2
CMS3_k127_2358235_0	215803.DB30_8576	6.238e-187	600.0	COG5368@1|root,COG5368@2|Bacteria,1NX2K@1224|Proteobacteria	1224|Proteobacteria	N	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Glycoamylase
CMS3_k127_2358235_1	215803.DB30_8575	1.093e-141	459.0	COG1653@1|root,COG1653@2|Bacteria,1MX59@1224|Proteobacteria	1224|Proteobacteria	G	ABC transporter substrate-binding protein	malE	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
CMS3_k127_235842_0	880073.Calab_3349	1.365e-135	445.0	COG0457@1|root,COG0457@2|Bacteria	880073.Calab_3349|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_235842_1	756272.Plabr_3629	6.58e-14	81.0	COG0457@1|root,COG0457@2|Bacteria	756272.Plabr_3629|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2360974_0	1242864.D187_008369	1.018e-59	235.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42S6I@68525|delta/epsilon subdivisions,2WNNW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TOBE domain	-	-	3.6.3.29,3.6.3.55	ko:K02017,ko:K06857	ko02010,map02010	M00186,M00189	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4,3.A.1.8	-	-	ABC_tran,TOBE
CMS3_k127_2360974_1	251221.35214857	2.84e-48	192.0	COG4149@1|root,COG4149@2|Bacteria,1G08P@1117|Cyanobacteria	1117|Cyanobacteria	P	molybdate ABC transporter, permease protein	modB	-	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1
CMS3_k127_2360974_2	697282.Mettu_3313	3.731e-06	55.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,1RQCV@1236|Gammaproteobacteria,1XEWF@135618|Methylococcales	135618|Methylococcales	P	ABC transporter, ATP-binding protein	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
CMS3_k127_2368459_3	575540.Isop_3510	1.052e-57	214.0	COG1801@1|root,COG1801@2|Bacteria,2IYWM@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
CMS3_k127_2368459_1	1128421.JAGA01000003_gene2922	5.249e-113	372.0	COG0479@1|root,COG0479@2|Bacteria,2NPY8@2323|unclassified Bacteria	2|Bacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
CMS3_k127_2368459_0	324602.Caur_1881	0.0	1037.0	COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi,374WX@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CMS3_k127_2368459_5	1267535.KB906767_gene403	4.303e-49	184.0	COG2009@1|root,COG2009@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	sdhC	-	-	ko:K00241,ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	iYO844.BSU28450	Sdh_cyt
CMS3_k127_2368459_2	1123070.KB899259_gene1957	9.822e-96	323.0	COG0545@1|root,COG0545@2|Bacteria,46U5S@74201|Verrucomicrobia,2IVK3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C
CMS3_k127_2368459_4	518766.Rmar_2582	6.091e-53	193.0	COG0493@1|root,COG0493@2|Bacteria,4NG9R@976|Bacteroidetes	976|Bacteroidetes	C	glutamate synthase	gltA	-	1.3.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K17722	ko00240,ko00250,ko00410,ko00770,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00410,map00770,map00910,map01100,map01110,map01120,map01130,map01230	M00046	R00093,R00114,R00248,R00977,R01414,R11026	RC00006,RC00010,RC00072,RC00123,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,Fer4_20,NAD_binding_1,Pyr_redox_2
CMS3_k127_238061_0	224308.BSU37890	1.269e-83	297.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,4HDN8@91061|Bacilli,1ZQW8@1386|Bacillus	91061|Bacilli	E	Belongs to the DegT DnrJ EryC1 family	spsC	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
CMS3_k127_238061_1	391587.KAOT1_15838	7.469e-09	68.0	COG3292@1|root,COG3292@2|Bacteria,4NDWE@976|Bacteroidetes,1HY9S@117743|Flavobacteriia	976|Bacteroidetes	T	periplasmic ligand-binding sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	Reg_prop
CMS3_k127_2388223_0	886293.Sinac_3361	1.068e-125	432.0	COG0357@1|root,COG0566@1|root,COG0357@2|Bacteria,COG0566@2|Bacteria,2J158@203682|Planctomycetes	203682|Planctomycetes	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB,SpoU_methylase
CMS3_k127_2388223_1	945713.IALB_3118	8.652e-55	205.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PKD,Peptidase_S8
CMS3_k127_2395652_0	1173027.Mic7113_0442	4.54e-50	193.0	COG0745@1|root,COG3437@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3437@2|Bacteria,COG5002@2|Bacteria,1G2MH@1117|Cyanobacteria,1H902@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
CMS3_k127_2395652_1	459349.CLOAM0132	4.635e-11	68.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NNRF@2323|unclassified Bacteria	2|Bacteria	MU	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,2.C.1.2	-	-	BSP,Bac_surface_Ag,PD40,Peptidase_MA_2
CMS3_k127_2399198_0	521011.Mpal_2209	7.236e-48	187.0	COG0614@1|root,COG3291@1|root,arCOG02510@2157|Archaea,arCOG03611@2157|Archaea	2157|Archaea	P	PFAM PKD domain containing protein	ush	-	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	CBM_6,DUF839,NHL,NosD,PKD,Peptidase_C1,Peptidase_S8
CMS3_k127_2399198_3	945713.IALB_1400	0.0002346	53.0	COG2911@1|root,COG2931@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	rtxA	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	ASH,CBM_2,Calx-beta,DUF4214,FlgD_ig,HemolysinCabind,SdrD_B
CMS3_k127_2399198_2	1298858.AUEL01000008_gene3529	0.0001512	54.0	COG0745@1|root,COG0745@2|Bacteria,1MX29@1224|Proteobacteria,2TV8G@28211|Alphaproteobacteria,43J4D@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	KT	RESPONSE REGULATOR receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2399198_1	697303.Thewi_0160	4.317e-47	181.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,247M7@186801|Clostridia,42EVR@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase family 4	tagO	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
CMS3_k127_2420664_0	502025.Hoch_6136	4.063e-167	535.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,42Q48@68525|delta/epsilon subdivisions,2X5G4@28221|Deltaproteobacteria,2YZF5@29|Myxococcales	28221|Deltaproteobacteria	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CMS3_k127_2420664_1	1210884.HG799464_gene10632	4.044e-68	246.0	COG1018@1|root,COG1018@2|Bacteria,2IXKZ@203682|Planctomycetes	203682|Planctomycetes	C	Oxidoreductase NAD-binding domain	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	NAD_binding_1
CMS3_k127_2429813_3	637390.AFOH01000112_gene2924	2.04e-21	99.0	COG1959@1|root,COG1959@2|Bacteria,1RE3F@1224|Proteobacteria,1TDGB@1236|Gammaproteobacteria,2NCVI@225057|Acidithiobacillales	225057|Acidithiobacillales	K	TIGRFAM Transcriptional regulator, Rrf2	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS3_k127_2429813_4	768671.ThimaDRAFT_4411	3.189e-08	60.0	COG3062@1|root,COG3062@2|Bacteria,1PUNN@1224|Proteobacteria,1TKDR@1236|Gammaproteobacteria,1X21U@135613|Chromatiales	135613|Chromatiales	P	NapD protein	-	-	-	ko:K02570	-	-	-	-	ko00000	-	-	-	NapD
CMS3_k127_2429813_0	768671.ThimaDRAFT_4410	0.0	1349.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1WW7D@135613|Chromatiales	135613|Chromatiales	C	Molybdopterin oxidoreductase Fe4S4 domain	napA	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS3_k127_2429813_2	354242.CJJ81176_0804	3.838e-28	119.0	COG3043@1|root,COG3043@2|Bacteria,1NAZB@1224|Proteobacteria,42SN1@68525|delta/epsilon subdivisions,2YPF9@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB	napB	-	-	ko:K02568	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798	RC02812	ko00000,ko00001,ko00002	-	-	-	NapB
CMS3_k127_2429813_1	156889.Mmc1_3025	3.208e-94	314.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,2UFYK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Seven times multi-haem cytochrome CxxCH	-	-	1.7.2.6	ko:K10535	ko00910,ko01120,map00910,map01120	M00528,M00804	R10164	RC00383	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrome_C554,Multi-haem_cyto
CMS3_k127_2436453_0	1499967.BAYZ01000011_gene5215	7.58e-152	511.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NNRF@2323|unclassified Bacteria	2|Bacteria	MU	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,2.C.1.2	-	-	BSP,Bac_surface_Ag,PD40,Peptidase_MA_2
CMS3_k127_2436453_1	237368.SCABRO_03458	4.448e-07	60.0	COG1520@1|root,COG3391@1|root,COG1520@2|Bacteria,COG3391@2|Bacteria,2J4EP@203682|Planctomycetes	203682|Planctomycetes	S	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS3_k127_2437367_0	247490.KSU1_C0025	5.478e-159	516.0	COG2192@1|root,COG2192@2|Bacteria,2IYCS@203682|Planctomycetes	2|Bacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS3_k127_2437367_2	1121405.dsmv_2878	6.006e-56	211.0	COG0438@1|root,COG0438@2|Bacteria,1N8I7@1224|Proteobacteria,430YI@68525|delta/epsilon subdivisions,2WVV4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1
CMS3_k127_2437367_1	316274.Haur_3584	2.493e-68	246.0	COG0367@1|root,COG0367@2|Bacteria,2G7R3@200795|Chloroflexi,374YC@32061|Chloroflexia	32061|Chloroflexia	F	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS3_k127_2438583_0	234267.Acid_5088	8.666e-209	660.0	COG1012@1|root,COG1012@2|Bacteria,3Y3CY@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_2438583_1	290397.Adeh_1677	3.835e-70	253.0	COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria,42NU5@68525|delta/epsilon subdivisions,2WJV4@28221|Deltaproteobacteria,2YX9Q@29|Myxococcales	28221|Deltaproteobacteria	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
CMS3_k127_2443127_1	443143.GM18_0341	6.102e-54	211.0	COG2133@1|root,COG2133@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2443127_2	378806.STAUR_8052	3.59e-14	81.0	2EV1C@1|root,33NGG@2|Bacteria,1NKKY@1224|Proteobacteria,42X6Y@68525|delta/epsilon subdivisions,2WTH7@28221|Deltaproteobacteria,2Z0VE@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2443127_0	1242864.D187_007813	1.726e-144	475.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	twitching motility protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS3_k127_245932_1	1449080.JQMV01000003_gene1264	3.407e-31	139.0	COG0849@1|root,COG0849@2|Bacteria,1WJ8M@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
CMS3_k127_245932_0	491915.Aflv_1823	5.34e-119	403.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,4H9WZ@91061|Bacilli,21W5U@150247|Anoxybacillus	91061|Bacilli	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
CMS3_k127_2471083_0	644966.Tmar_0429	5.012e-24	113.0	COG0741@1|root,COG0741@2|Bacteria,1V6K4@1239|Firmicutes,24JB5@186801|Clostridia,3WDCQ@538999|Clostridiales incertae sedis	186801|Clostridia	M	Transglycosylase SLT domain	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
CMS3_k127_2471083_1	7739.XP_002586161.1	2.449e-11	76.0	KOG2177@1|root,KOG2177@2759|Eukaryota	7739.XP_002586161.1|-	O	zinc ion binding	-	-	-	ko:K11997	-	-	-	-	ko00000,ko04121	-	-	-	-
CMS3_k127_2471083_2	194439.CT1714	4.006e-11	74.0	COG0170@1|root,COG0170@2|Bacteria,1FDXW@1090|Chlorobi	1090|Chlorobi	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2472047_0	247490.KSU1_C0744	5.405e-167	537.0	COG2403@1|root,COG2403@2|Bacteria,2J2N6@203682|Planctomycetes	203682|Planctomycetes	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2472047_1	635013.TherJR_0353	7.475e-118	384.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,2608G@186807|Peptococcaceae	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.6,2.1.3.9	ko:K00611,ko:K09065,ko:K13252	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12430	OTCace,OTCace_N
CMS3_k127_2484664_1	1128421.JAGA01000003_gene2871	2.253e-22	100.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	nrfD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
CMS3_k127_2484664_0	649638.Trad_1026	3.949e-234	741.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1WI5T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
CMS3_k127_2487777_0	562970.Btus_0129	7.056e-132	436.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,4HAKH@91061|Bacilli,2783Y@186823|Alicyclobacillaceae	91061|Bacilli	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0009986,GO:0030246,GO:0030247,GO:0044464,GO:2001065	6.1.1.24	ko:K09698	ko00970,ko01100,map00970,map01100	M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iSB619.SA_RS02860	tRNA-synt_1c
CMS3_k127_2487777_1	471852.Tcur_3455	1.027e-35	143.0	COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,4EI19@85012|Streptosporangiales	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
CMS3_k127_2499415_0	1125863.JAFN01000001_gene2068	1.472e-211	696.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
CMS3_k127_2499415_2	713586.KB900536_gene2644	0.0003958	52.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1WW9X@135613|Chromatiales	135613|Chromatiales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
CMS3_k127_2499415_1	1379698.RBG1_1C00001G1136	9.902e-25	117.0	COG2956@1|root,COG2956@2|Bacteria	2|Bacteria	G	lipopolysaccharide metabolic process	ciaB	-	-	ko:K07502,ko:K08309,ko:K19804,ko:K21572	-	-	-	-	ko00000,ko01000,ko01011,ko02000	8.A.46.1,8.A.46.3	GH23	-	SusD-like_3,SusD_RagB,TPR_16,TPR_6,TPR_8
CMS3_k127_2520311_1	215803.DB30_8578	1.38e-86	299.0	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,42RM3@68525|delta/epsilon subdivisions,2WNTS@28221|Deltaproteobacteria,2Z0EJ@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529,ko:K03435	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
CMS3_k127_2520311_0	240016.ABIZ01000001_gene2509	0.0	1142.0	COG3459@1|root,COG3459@2|Bacteria,46UFY@74201|Verrucomicrobia,2IU75@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36
CMS3_k127_2520311_2	84531.JMTZ01000011_gene3095	8.55e-71	246.0	COG3408@1|root,COG3408@2|Bacteria,1QU1Q@1224|Proteobacteria,1RRX2@1236|Gammaproteobacteria,1X4YN@135614|Xanthomonadales	135614|Xanthomonadales	G	coagulation factor 5 8 type	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,F5_F8_type_C,GDE_C
CMS3_k127_2537992_0	396588.Tgr7_1432	7.063e-71	248.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1WW3F@135613|Chromatiales	135613|Chromatiales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
CMS3_k127_2537992_1	161156.JQKW01000006_gene1394	9.681e-46	182.0	COG2518@1|root,COG2518@2|Bacteria,2GH2E@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CMS3_k127_2541174_0	1131269.AQVV01000007_gene1061	3.983e-32	127.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup	-	-	ko:K03530,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS3_k127_2541174_1	926569.ANT_00730	9.144e-25	118.0	COG1287@1|root,COG1287@2|Bacteria,2G9P1@200795|Chloroflexi	200795|Chloroflexi	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_2541174_2	1049564.TevJSym_aq00520	3.177e-06	58.0	2DYV5@1|root,34B8N@2|Bacteria,1N2KH@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2571816_3	443143.GM18_1469	1.718e-56	217.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42N7S@68525|delta/epsilon subdivisions,2WMBC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	SMART AAA ATPase	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
CMS3_k127_2571816_1	290397.Adeh_2455	1.681e-70	246.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
CMS3_k127_2571816_0	861299.J421_2672	2.311e-85	293.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2571816_2	1379698.RBG1_1C00001G1249	1.262e-61	220.0	COG3170@1|root,COG3170@2|Bacteria,2NPQF@2323|unclassified Bacteria	2|Bacteria	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
CMS3_k127_2573492_2	1121440.AUMA01000009_gene708	0.0004084	48.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL,Lipase_GDSL_2
CMS3_k127_2573492_0	880073.Calab_0984	2.876e-96	334.0	COG0265@1|root,COG0265@2|Bacteria,2NQK9@2323|unclassified Bacteria	2|Bacteria	O	Trypsin	degQ	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_2573492_1	880073.Calab_0985	2.147e-06	57.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	FGE-sulfatase,PDZ_2
CMS3_k127_2580383_0	1191523.MROS_0773	0.0	1373.0	COG3696@1|root,COG3696@2|Bacteria	2|Bacteria	P	silver ion transport	czcA	-	-	ko:K07787,ko:K15726	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.2,2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
CMS3_k127_2580383_1	945713.IALB_0866	1.166e-22	100.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23
CMS3_k127_25845_1	485918.Cpin_5859	1.426e-52	189.0	COG4119@1|root,COG4119@2|Bacteria,4NRRR@976|Bacteroidetes,1ITJZ@117747|Sphingobacteriia	976|Bacteroidetes	L	pfam nudix	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS3_k127_25845_0	391587.KAOT1_14757	8.422e-291	908.0	COG0339@1|root,COG0339@2|Bacteria,4NFYA@976|Bacteroidetes,1HY0G@117743|Flavobacteriia	976|Bacteroidetes	E	Peptidase family M3	-	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
CMS3_k127_2589262_0	1123242.JH636435_gene1286	5.457e-50	188.0	COG1131@1|root,COG1131@2|Bacteria,2IY79@203682|Planctomycetes	203682|Planctomycetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_2589262_3	1382304.JNIL01000001_gene1007	3.489e-20	94.0	COG1725@1|root,COG1725@2|Bacteria,1VFD0@1239|Firmicutes,4HNIT@91061|Bacilli,27A9H@186823|Alicyclobacillaceae	91061|Bacilli	K	helix_turn_helix gluconate operon transcriptional repressor	ytrA	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS3_k127_2589262_1	234267.Acid_5354	1.894e-38	154.0	COG2204@1|root,COG2208@1|root,COG2204@2|Bacteria,COG2208@2|Bacteria,3Y49J@57723|Acidobacteria	57723|Acidobacteria	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
CMS3_k127_2589262_4	1177179.A11A3_11182	3.43e-06	53.0	COG2906@1|root,COG2906@2|Bacteria,1NGGY@1224|Proteobacteria,1SGGM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Bacterioferritin-associated ferredoxin	bfd	-	-	ko:K02192	-	-	-	-	ko00000	-	-	-	Fer2_BFD
CMS3_k127_2589262_2	222534.KB893694_gene97	4.305e-35	139.0	COG2193@1|root,COG2193@2|Bacteria,2GJEI@201174|Actinobacteria,4ESV8@85013|Frankiales	201174|Actinobacteria	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
CMS3_k127_2591097_0	1499689.CCNN01000007_gene1053	6.773e-47	187.0	COG0420@1|root,COG0420@2|Bacteria,1TWMI@1239|Firmicutes,24BN3@186801|Clostridia,36FXK@31979|Clostridiaceae	186801|Clostridia	L	DNA repair exonuclease	-	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
CMS3_k127_2604341_1	251221.35214697	3.314e-123	402.0	COG0444@1|root,COG0444@2|Bacteria,1G1NU@1117|Cyanobacteria	1117|Cyanobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS3_k127_2604341_2	1183438.GKIL_1123	8.048e-103	357.0	COG1173@1|root,COG1173@2|Bacteria,1G0CD@1117|Cyanobacteria	1117|Cyanobacteria	P	'ABC-type dipeptide oligopeptide nickel transport	appC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
CMS3_k127_2604341_3	1254432.SCE1572_21010	4.764e-97	351.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,43AFB@68525|delta/epsilon subdivisions,2X5XK@28221|Deltaproteobacteria,2Z2YK@29|Myxococcales	28221|Deltaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	appB	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
CMS3_k127_2604341_0	314287.GB2207_02287	2.423e-130	447.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,1J6HF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	ABC-type oligopeptide transport system, periplasmic component	oppA	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
CMS3_k127_2604341_4	909663.KI867150_gene1727	9.546e-13	82.0	29YAX@1|root,30K55@2|Bacteria,1NQ6Z@1224|Proteobacteria,42XV0@68525|delta/epsilon subdivisions,2WTAS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_2605220_0	1499967.BAYZ01000159_gene546	2.28e-174	580.0	2EYYT@1|root,33S5J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2605220_3	1472716.KBK24_0127695	3.377e-47	193.0	COG3637@1|root,COG3637@2|Bacteria,1R94P@1224|Proteobacteria,2VQ60@28216|Betaproteobacteria,1K652@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2605220_1	864702.OsccyDRAFT_3828	1.096e-148	488.0	COG1215@1|root,COG1215@2|Bacteria,1G1PN@1117|Cyanobacteria,1H9ZX@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3
CMS3_k127_2605220_2	670292.JH26_15675	1.75e-77	280.0	COG0457@1|root,COG0457@2|Bacteria,1NQ71@1224|Proteobacteria,2UQI7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tetratrico peptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_5
CMS3_k127_2607038_0	574087.Acear_2111	1.748e-91	312.0	COG1086@1|root,COG1086@2|Bacteria,1TR3W@1239|Firmicutes,247PW@186801|Clostridia,3WB7N@53433|Halanaerobiales	186801|Clostridia	GM	PFAM polysaccharide biosynthesis protein CapD	capD	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
CMS3_k127_2607038_1	1237149.C900_02873	8.122e-71	252.0	COG0500@1|root,COG2226@2|Bacteria,4P2IZ@976|Bacteroidetes	976|Bacteroidetes	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2607038_2	82654.Pse7367_2906	1.867e-06	51.0	COG2242@1|root,COG2242@2|Bacteria	2|Bacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
CMS3_k127_2611613_11	639030.JHVA01000001_gene2022	8.12e-58	211.0	COG3794@1|root,COG3794@2|Bacteria,3Y4C0@57723|Acidobacteria,2JJME@204432|Acidobacteriia	204432|Acidobacteriia	C	Polysaccharide lyase family 4, domain II	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_2611613_7	644966.Tmar_0543	9.958e-73	254.0	COG1573@1|root,COG1573@2|Bacteria,1V2PR@1239|Firmicutes,24JK1@186801|Clostridia	186801|Clostridia	L	UreE urease accessory protein, C-terminal domain	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS3_k127_2611613_4	743722.Sph21_1081	9.431e-81	291.0	COG2355@1|root,COG2355@2|Bacteria,4NEBG@976|Bacteroidetes,1IQAA@117747|Sphingobacteriia	976|Bacteroidetes	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
CMS3_k127_2611613_15	1357272.AVEO02000188_gene4380	2.702e-12	75.0	COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,1RMEM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	ABC transporter ATP-binding protein	-	-	-	ko:K11963	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
CMS3_k127_2611613_0	1121430.JMLG01000005_gene717	5.052e-150	497.0	COG3276@1|root,COG3276@2|Bacteria,1TPQS@1239|Firmicutes,2484U@186801|Clostridia,260IK@186807|Peptococcaceae	186801|Clostridia	J	Elongation factor Tu domain 2	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
CMS3_k127_2611613_9	886293.Sinac_2319	3.593e-68	235.0	COG0432@1|root,COG0432@2|Bacteria,2IZ7Q@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CMS3_k127_2611613_6	309807.SRU_0977	3.774e-76	284.0	2AB2F@1|root,310G6@2|Bacteria,4PEZP@976|Bacteroidetes,1FJWS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2611613_14	574087.Acear_2201	4.279e-15	88.0	COG4775@1|root,COG4775@2|Bacteria,1UMDS@1239|Firmicutes,24F0X@186801|Clostridia,3WAA6@53433|Halanaerobiales	186801|Clostridia	M	PFAM Surface antigen variable number repeat	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
CMS3_k127_2611613_12	187272.Mlg_1738	6.686e-32	133.0	COG0704@1|root,COG0704@2|Bacteria,1NRGK@1224|Proteobacteria,1SMQP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	PhoU domain	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
CMS3_k127_2611613_5	1125863.JAFN01000001_gene2573	3.711e-79	283.0	COG1283@1|root,COG1283@2|Bacteria,1MXWU@1224|Proteobacteria	1224|Proteobacteria	P	phosphate symporter	nptA	-	-	ko:K14683	-	-	-	-	ko00000,ko02000,ko04147	2.A.58.1	-	-	Na_Pi_cotrans
CMS3_k127_2611613_1	398767.Glov_0818	4.685e-136	445.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the EPSP synthase family. MurA subfamily	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
CMS3_k127_2611613_10	338963.Pcar_2691	1.715e-62	226.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WM9R@28221|Deltaproteobacteria,43S3F@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Putative RNA methylase family UPF0020	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_25,Methyltransf_31
CMS3_k127_2611613_3	555079.Toce_2072	4.111e-124	408.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,42FEW@68295|Thermoanaerobacterales	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CMS3_k127_2611613_8	546271.Selsp_2190	7.361e-72	257.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,4H271@909932|Negativicutes	909932|Negativicutes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
CMS3_k127_2611613_13	1379698.RBG1_1C00001G0690	7.136e-27	111.0	COG0254@1|root,COG0254@2|Bacteria,2NPUV@2323|unclassified Bacteria	2|Bacteria	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
CMS3_k127_2611613_2	1379698.RBG1_1C00001G0312	6.51e-136	436.0	COG1158@1|root,COG1158@2|Bacteria,2NNXC@2323|unclassified Bacteria	2|Bacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02887,ko:K03628	ko03010,ko03018,map03010,map03018	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
CMS3_k127_261610_0	1379698.RBG1_1C00001G1218	1.752e-107	385.0	COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria	2|Bacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_8
CMS3_k127_261610_1	251221.35211586	1.777e-87	297.0	COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria	1117|Cyanobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
CMS3_k127_261977_0	1379698.RBG1_1C00001G0342	5.492e-45	171.0	COG2908@1|root,COG2908@2|Bacteria,2NPKW@2323|unclassified Bacteria	2|Bacteria	S	Calcineurin-like phosphoesterase	lpxH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iE2348C_1286.E2348C_0457	Metallophos,Metallophos_2
CMS3_k127_261977_1	1121033.AUCF01000028_gene377	1.38e-31	132.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2JQVG@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the peptidase S1C family	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_2623805_0	880073.Calab_0513	5.792e-84	295.0	2C3GN@1|root,31EWU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2623805_1	743299.Acife_1096	5.029e-47	178.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,2NBQP@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	2.1.1.200	ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
CMS3_k127_2623805_2	1047013.AQSP01000088_gene1634	2.641e-07	61.0	COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,2NR7I@2323|unclassified Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF560,Dynamin_N,Peptidase_M48,TPR_19,TPR_8
CMS3_k127_2627200_5	871968.DESME_03115	1.811e-14	85.0	COG1012@1|root,COG1012@2|Bacteria,1UN2Y@1239|Firmicutes,25GVM@186801|Clostridia	186801|Clostridia	C	Acyl-CoA reductase (LuxC)	-	-	-	-	-	-	-	-	-	-	-	-	LuxC
CMS3_k127_2627200_3	123899.JPQP01000023_gene3013	1.977e-50	196.0	COG1541@1|root,COG1541@2|Bacteria,1NR5G@1224|Proteobacteria,2VHRP@28216|Betaproteobacteria,3T77K@506|Alcaligenaceae	28216|Betaproteobacteria	H	Acyl-protein synthetase, LuxE	luxE	-	-	-	-	-	-	-	-	-	-	-	LuxE
CMS3_k127_2627200_0	1123070.KB899254_gene1284	3.267e-111	378.0	COG0160@1|root,COG0160@2|Bacteria,46UEH@74201|Verrucomicrobia,2IVU9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
CMS3_k127_2627200_2	1120999.JONM01000004_gene3644	7.891e-73	254.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2VGZ7@28216|Betaproteobacteria,2KQB7@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
CMS3_k127_2627200_4	1191523.MROS_1662	5.553e-38	152.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27	ko:K01096,ko:K19302	ko00550,ko00564,ko01100,map00550,map00564,map01100	-	R02029,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
CMS3_k127_2627200_1	448385.sce7626	2.012e-84	291.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42RBW@68525|delta/epsilon subdivisions,2X5G8@28221|Deltaproteobacteria,2Z35G@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_2634607_6	405948.SACE_0607	1.43e-23	104.0	COG0688@1|root,COG0688@2|Bacteria,2IGKJ@201174|Actinobacteria,4EAPT@85010|Pseudonocardiales	201174|Actinobacteria	I	Phosphatidylserine decarboxylase	-	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
CMS3_k127_2634607_3	469383.Cwoe_4173	1.461e-48	186.0	COG0354@1|root,COG0354@2|Bacteria,2GKP0@201174|Actinobacteria,4CQCX@84995|Rubrobacteria	84995|Rubrobacteria	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
CMS3_k127_2634607_1	204669.Acid345_3487	7.878e-90	302.0	COG3279@1|root,COG3279@2|Bacteria,3Y3B3@57723|Acidobacteria,2JP1W@204432|Acidobacteriia	204432|Acidobacteriia	KT	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
CMS3_k127_2634607_2	204669.Acid345_3488	4.5e-80	279.0	COG2972@1|root,COG2972@2|Bacteria,3Y4BE@57723|Acidobacteria,2JMFY@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
CMS3_k127_2634607_4	883126.HMPREF9710_04256	1.315e-45	176.0	COG4758@1|root,COG4758@2|Bacteria,1RFX6@1224|Proteobacteria,2WCSU@28216|Betaproteobacteria,4772Z@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2634607_7	1229276.DI53_0788	0.000776	48.0	2AX7X@1|root,31P6Q@2|Bacteria,4NGGX@976|Bacteroidetes,1ISH8@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2634607_0	880073.Calab_3175	4.265e-143	463.0	COG1064@1|root,COG1064@2|Bacteria,2NP06@2323|unclassified Bacteria	2|Bacteria	S	Alcohol dehydrogenase GroES-like domain	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_2634607_5	215803.DB30_3073	3.005e-40	170.0	COG0726@1|root,COG4319@1|root,COG0726@2|Bacteria,COG4319@2|Bacteria,1RFCG@1224|Proteobacteria,43BYQ@68525|delta/epsilon subdivisions,2X79K@28221|Deltaproteobacteria,2Z21H@29|Myxococcales	28221|Deltaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
CMS3_k127_2648083_2	1097668.BYI23_B003500	4.878e-10	64.0	COG2331@1|root,COG2331@2|Bacteria,1NMRY@1224|Proteobacteria,2W531@28216|Betaproteobacteria,1KAFV@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
CMS3_k127_2648083_0	1382359.JIAL01000001_gene1560	1.25e-160	518.0	COG1960@1|root,COG1960@2|Bacteria,3Y32R@57723|Acidobacteria,2JIRM@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1,1.3.99.12	ko:K00248,ko:K09478	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_2648083_1	298655.KI912266_gene1062	2.415e-30	121.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4ESB0@85013|Frankiales	201174|Actinobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
CMS3_k127_267399_0	926569.ANT_14860	1.523e-79	271.0	COG1167@1|root,COG1167@2|Bacteria,2G61E@200795|Chloroflexi	200795|Chloroflexi	EK	PFAM Aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
CMS3_k127_267399_2	945713.IALB_1840	1.069e-38	151.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Cytochrome_C554,DUF11,SLH
CMS3_k127_267399_1	379066.GAU_2304	1.759e-39	162.0	COG3595@1|root,COG3595@2|Bacteria,1ZTJA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS3_k127_2674226_2	1121405.dsmv_1571	2.275e-12	77.0	2FHTG@1|root,349KR@2|Bacteria,1P1C2@1224|Proteobacteria,4318F@68525|delta/epsilon subdivisions,2WWJT@28221|Deltaproteobacteria,2MNZ8@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2674226_1	682795.AciX8_3927	5.927e-14	85.0	COG1269@1|root,COG1269@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_2674226_0	518766.Rmar_1322	6.89e-28	121.0	COG0438@1|root,COG0438@2|Bacteria,4NE6S@976|Bacteroidetes,1FIXH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_2683388_0	880073.Calab_1754	2.992e-90	318.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.4,3.4.21.66	ko:K01179,ko:K08651	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH5,GH9	-	Autotransporter,PKD,Peptidase_S8,Peptidase_S8_N,fn3
CMS3_k127_2683388_1	323261.Noc_1193	4.947e-23	106.0	COG1266@1|root,COG1266@2|Bacteria,1RI59@1224|Proteobacteria,1S8JI@1236|Gammaproteobacteria,1X1V3@135613|Chromatiales	135613|Chromatiales	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
CMS3_k127_2707760_3	1191523.MROS_0297	1.213e-53	198.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria	2|Bacteria	M	undecaprenyl-phosphate glucose phosphotransferase activity	wcaJ	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046402,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.187,2.7.8.40	ko:K05946,ko:K21303	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01005	-	GT26	-	Bac_transf,CoA_binding_3
CMS3_k127_2707760_1	1121439.dsat_1281	1.563e-73	265.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42T55@68525|delta/epsilon subdivisions,2WPW2@28221|Deltaproteobacteria,2MG3X@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_2707760_0	1121439.dsat_1279	1.665e-134	454.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42PY9@68525|delta/epsilon subdivisions,2WMGG@28221|Deltaproteobacteria,2MATU@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	coenzyme F390	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	-
CMS3_k127_2707760_5	1234595.C725_1135	0.0005216	51.0	COG4932@1|root,COG4932@2|Bacteria,1NKJ9@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
CMS3_k127_2707760_2	1121439.dsat_1282	2.069e-61	228.0	COG1215@1|root,COG1215@2|Bacteria,1NDPE@1224|Proteobacteria,439Z2@68525|delta/epsilon subdivisions,2X1YW@28221|Deltaproteobacteria,2M834@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_2707760_4	194867.ALBQ01000034_gene1060	8.128e-15	81.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2TT1Y@28211|Alphaproteobacteria,2K00D@204457|Sphingomonadales	204457|Sphingomonadales	D	protein involved in exopolysaccharide biosynthesis	-	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,GNVR,Wzz
CMS3_k127_2708563_1	279714.FuraDRAFT_2524	4.412e-35	138.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria	28216|Betaproteobacteria	L	DEAD DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
CMS3_k127_2708563_0	880073.Calab_3313	1.185e-62	228.0	COG1331@1|root,COG1331@2|Bacteria	2|Bacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Pec_lyase,Thioredoxin_7
CMS3_k127_2710992_1	589865.DaAHT2_2481	4.647e-44	173.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1NPFY@1224|Proteobacteria,43BU7@68525|delta/epsilon subdivisions,2X757@28221|Deltaproteobacteria,2MJ6M@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10,2.1.1.13	ko:K00297,ko:K00547,ko:K00548	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,ko01523,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230,map01523	M00017,M00377	R00650,R00946,R01224,R07168,R09365	RC00003,RC00035,RC00081,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
CMS3_k127_2710992_0	525904.Tter_0425	1.811e-113	380.0	COG0627@1|root,COG0627@2|Bacteria,2NQQ3@2323|unclassified Bacteria	2|Bacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS3_k127_2710992_2	1522072.IL54_2675	0.0004289	50.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2K26Q@204457|Sphingomonadales	204457|Sphingomonadales	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_16,TPR_19,TPR_8
CMS3_k127_2711654_3	1254432.SCE1572_01825	8.105e-24	117.0	COG3857@1|root,COG3857@2|Bacteria,1QXU1@1224|Proteobacteria,43C6K@68525|delta/epsilon subdivisions,2X7GU@28221|Deltaproteobacteria,2Z1DQ@29|Myxococcales	28221|Deltaproteobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
CMS3_k127_2711654_1	1191523.MROS_0145	5.943e-41	164.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	pagO	-	-	ko:K07790	ko02020,map02020	-	-	-	ko00000,ko00001	2.A.7	-	-	EamA
CMS3_k127_2711654_5	265729.GS18_0203050	2.57e-10	70.0	COG1525@1|root,COG1525@2|Bacteria,1V3MZ@1239|Firmicutes,4HHPS@91061|Bacilli,1ZFIZ@1386|Bacillus	91061|Bacilli	L	Staphylococcal nuclease homologues	nucH	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	Excalibur,SNase
CMS3_k127_2711654_0	65393.PCC7424_4795	3.079e-205	648.0	COG1690@1|root,COG1690@2|Bacteria,1G0YE@1117|Cyanobacteria,3KJTQ@43988|Cyanothece	1117|Cyanobacteria	H	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
CMS3_k127_2711654_4	118163.Ple7327_0387	1.208e-20	96.0	COG1371@1|root,COG1371@2|Bacteria,1G81W@1117|Cyanobacteria	1117|Cyanobacteria	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
CMS3_k127_2711654_2	1550091.JROE01000007_gene2705	1.531e-32	132.0	COG2259@1|root,COG2259@2|Bacteria,4NTM8@976|Bacteroidetes,1ITB2@117747|Sphingobacteriia	976|Bacteroidetes	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
CMS3_k127_2715701_1	1128421.JAGA01000001_gene2365	2.2e-19	89.0	COG1600@1|root,COG1600@2|Bacteria,2NNWV@2323|unclassified Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
CMS3_k127_2715701_0	797209.ZOD2009_13017	6.078e-137	451.0	COG0076@1|root,arCOG00027@2157|Archaea,2Y37G@28890|Euryarchaeota,23ZDQ@183963|Halobacteria	183963|Halobacteria	E	COG0076 Glutamate decarboxylase and related PLP-dependent proteins	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
CMS3_k127_2715701_2	944480.ATUV01000002_gene84	1.427e-13	83.0	COG2050@1|root,COG2050@2|Bacteria,1N8F8@1224|Proteobacteria,42V78@68525|delta/epsilon subdivisions,2WRBA@28221|Deltaproteobacteria,2M7BC@213113|Desulfurellales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS3_k127_2728519_0	1121104.AQXH01000001_gene1789	4.563e-49	200.0	COG1572@1|root,COG1572@2|Bacteria,4NDY7@976|Bacteroidetes,1IW9T@117747|Sphingobacteriia	976|Bacteroidetes	S	Peptidase family C25	porU	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
CMS3_k127_2740419_0	330214.NIDE2284	3.913e-112	379.0	COG2204@1|root,COG2204@2|Bacteria,3J0FP@40117|Nitrospirae	40117|Nitrospirae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_2740419_1	518766.Rmar_0760	0.000137	53.0	COG1419@1|root,COG1419@2|Bacteria,4PF3E@976|Bacteroidetes,1FK2R@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	N	SRP54-type protein, GTPase domain	-	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
CMS3_k127_2744275_0	1125863.JAFN01000001_gene1462	4.447e-181	578.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
CMS3_k127_2745600_3	1191523.MROS_1592	2.986e-108	370.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS3_k127_2745600_5	1191523.MROS_1577	3.54e-90	324.0	COG2152@1|root,COG2152@2|Bacteria	2|Bacteria	G	transferase activity, transferring glycosyl groups	-	-	2.4.1.319,2.4.1.320	ko:K18785	-	-	R10811,R10829	RC00049	ko00000,ko01000	-	-	-	Glyco_hydro_130
CMS3_k127_2745600_4	518766.Rmar_2792	6.969e-105	353.0	COG3509@1|root,COG3509@2|Bacteria,4NENB@976|Bacteroidetes,1FJW7@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS3_k127_2745600_2	1333856.L686_07050	1.284e-123	411.0	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,1RP78@1236|Gammaproteobacteria,1Z2DE@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	Belongs to the carbamate kinase family	arcC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	iE2348C_1286.E2348C_0454,iECED1_1282.ECED1_0540,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641	AA_kinase
CMS3_k127_2745600_0	404589.Anae109_1659	2.799e-217	689.0	28MMZ@1|root,2ZAXK@2|Bacteria,1R7WU@1224|Proteobacteria,42QIC@68525|delta/epsilon subdivisions,2WKJJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2745600_1	414684.RC1_2706	2.432e-173	571.0	COG0591@1|root,COG0591@2|Bacteria,1PNHU@1224|Proteobacteria	1224|Proteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
CMS3_k127_2745600_6	1121468.AUBR01000004_gene141	1.69e-10	73.0	COG5423@1|root,COG5423@2|Bacteria,1UQP8@1239|Firmicutes,24E21@186801|Clostridia,42GUN@68295|Thermoanaerobacterales	186801|Clostridia	S	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284,Dimerisation2,Methyltransf_2
CMS3_k127_2746411_0	748280.NH8B_2766	0.0	1585.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria	28216|Betaproteobacteria	L	DEAD DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
CMS3_k127_2746411_5	1437603.BMON_0615	3.827e-07	60.0	COG4262@1|root,COG4262@2|Bacteria,2I372@201174|Actinobacteria,4D060@85004|Bifidobacteriales	201174|Actinobacteria	S	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
CMS3_k127_2746411_3	869210.Marky_0294	1.539e-68	244.0	COG4665@1|root,COG4665@2|Bacteria,1WJCH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	TRAP-type mannitol chloroaromatic compound transport system small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
CMS3_k127_2746411_1	518766.Rmar_2648	1.54e-203	641.0	COG4664@1|root,COG4664@2|Bacteria,4PM5T@976|Bacteroidetes,1FIK6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
CMS3_k127_2746411_2	1242864.D187_009598	9.953e-142	464.0	COG1502@1|root,COG1502@2|Bacteria,1R9I4@1224|Proteobacteria,4340H@68525|delta/epsilon subdivisions,2X4F2@28221|Deltaproteobacteria,2YYWF@29|Myxococcales	28221|Deltaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
CMS3_k127_2747642_1	584708.Apau_0378	3.609e-51	205.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	4.6.1.1	ko:K01768,ko:K20977	ko00230,ko02020,ko02025,ko04113,ko04213,map00230,map02020,map02025,map04113,map04213	M00695,M00820	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GAF,HATPase_c,HATPase_c_2,HisKA,Response_reg,SpoIIE
CMS3_k127_2747642_2	1117943.SFHH103_03615	2.976e-26	114.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2U745@28211|Alphaproteobacteria,4BFWW@82115|Rhizobiaceae	28211|Alphaproteobacteria	KT	cheY-homologous receiver domain	divK	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
CMS3_k127_2747642_0	671143.DAMO_2593	3.29e-71	263.0	COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,2NS4N@2323|unclassified Bacteria	2|Bacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	2.7.13.3	ko:K03407,ko:K07678,ko:K18143	ko01501,ko02020,ko02025,ko02026,ko02030,ko05111,map01501,map02020,map02025,map02026,map02030,map05111	M00475,M00506,M00649,M00655	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022,ko02035	-	-	-	4HB_MCP_1,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
CMS3_k127_275142_0	945713.IALB_1035	1.519e-264	837.0	COG1217@1|root,COG1217@2|Bacteria	2|Bacteria	T	GTPase activity	typA	GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
CMS3_k127_275142_2	1254432.SCE1572_26695	1.35e-23	115.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,42PWI@68525|delta/epsilon subdivisions,2WPU4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
CMS3_k127_275142_1	671143.DAMO_2498	2.502e-58	207.0	COG1180@1|root,COG1180@2|Bacteria,2NP82@2323|unclassified Bacteria	2|Bacteria	O	Radical SAM superfamily	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS3_k127_2753337_4	251229.Chro_0876	5.633e-22	109.0	COG1216@1|root,COG3250@1|root,COG1216@2|Bacteria,COG3250@2|Bacteria,1G2MT@1117|Cyanobacteria,3VNJZ@52604|Pleurocapsales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
CMS3_k127_2753337_1	572477.Alvin_1965	3.715e-132	429.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1WWNR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2,5.1.3.5	ko:K01784,ko:K12448	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01473,R02984	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
CMS3_k127_2753337_0	395493.BegalDRAFT_2277	1.999e-158	507.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,1RNJD@1236|Gammaproteobacteria,46189@72273|Thiotrichales	72273|Thiotrichales	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS3_k127_2753337_2	574966.KB898647_gene2265	1.421e-57	210.0	COG0221@1|root,COG0221@2|Bacteria,1RF8Z@1224|Proteobacteria,1S4VZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Inorganic pyrophosphatase	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
CMS3_k127_2753337_5	1183438.GKIL_1975	2.743e-07	63.0	COG1396@1|root,COG2856@1|root,COG1396@2|Bacteria,COG2856@2|Bacteria,1GAYI@1117|Cyanobacteria	1117|Cyanobacteria	K	Pfam:DUF955	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Peptidase_M78
CMS3_k127_2753337_3	696281.Desru_2333	1.313e-34	136.0	COG0461@1|root,COG0461@2|Bacteria,1V1BZ@1239|Firmicutes,25CGM@186801|Clostridia,261GR@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
CMS3_k127_2758050_0	1408433.JHXV01000005_gene2233	4.382e-46	184.0	COG2357@1|root,COG2357@2|Bacteria,4NFMF@976|Bacteroidetes,1HWNT@117743|Flavobacteriia	976|Bacteroidetes	S	RelA SpoT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GTA_TIM
CMS3_k127_2758050_1	1173026.Glo7428_3255	2.616e-40	151.0	COG2343@1|root,COG2343@2|Bacteria,1G7U6@1117|Cyanobacteria	1117|Cyanobacteria	S	COGs COG2343 conserved	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
CMS3_k127_2766564_3	1380355.JNIJ01000009_gene1689	8.812e-28	119.0	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,2TUJD@28211|Alphaproteobacteria,3JWCP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_2766564_1	1340493.JNIF01000003_gene2503	1.623e-80	283.0	COG0577@1|root,COG0577@2|Bacteria,3Y4C7@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS3_k127_2766564_0	1121468.AUBR01000015_gene2268	9.919e-100	351.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,42ESC@68295|Thermoanaerobacterales	186801|Clostridia	P	TIGRFAM potassium uptake protein, TrkH family	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS3_k127_2766564_2	373903.Hore_11690	4.087e-47	177.0	COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia,3WAZ8@53433|Halanaerobiales	186801|Clostridia	P	PFAM TrkA-N domain	ktrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS3_k127_2766863_1	1159870.KB907784_gene553	1.218e-36	140.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria,3T708@506|Alcaligenaceae	28216|Betaproteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
CMS3_k127_2766863_0	1121904.ARBP01000004_gene917	0.0	1165.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,4NFBV@976|Bacteroidetes,47K85@768503|Cytophagia	976|Bacteroidetes	EQ	Hydantoinase/oxoprolinase	-	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
CMS3_k127_2766863_2	195250.CM001776_gene2702	0.0008282	42.0	2CCCK@1|root,2Z7UH@2|Bacteria,1GGQS@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2772855_1	1380390.JIAT01000010_gene4361	1.589e-60	225.0	2C1GN@1|root,33V5B@2|Bacteria,2H4C5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2772855_6	1312959.KI914642_gene1220	3.297e-09	71.0	2E2EJ@1|root,32XJ3@2|Bacteria,2ISI6@201174|Actinobacteria	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS3_k127_2772855_0	357808.RoseRS_2371	9.367e-109	379.0	COG0438@1|root,COG0438@2|Bacteria,2G9B8@200795|Chloroflexi,376I5@32061|Chloroflexia	32061|Chloroflexia	H	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_2772855_4	670292.JH26_16725	2.37e-32	138.0	COG0726@1|root,COG0726@2|Bacteria,1R7PS@1224|Proteobacteria,2TU1B@28211|Alphaproteobacteria,1JSKP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,NodS,Polysacc_deac_1
CMS3_k127_2772855_8	1382359.JIAL01000001_gene543	1.364e-06	57.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	-	2.1.1.45,2.7.4.9	ko:K00560,ko:K00943	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02094,R02098,R02101	RC00002,RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
CMS3_k127_2772855_5	1158050.KB895461_gene2928	4.677e-23	109.0	COG0125@1|root,COG3173@1|root,COG0125@2|Bacteria,COG3173@2|Bacteria,2H78H@201174|Actinobacteria	201174|Actinobacteria	F	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2772855_3	1158050.KB895452_gene605	2.101e-32	144.0	2AFPW@1|root,319YB@2|Bacteria,2HCD4@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2772855_2	1276756.AUEX01000004_gene2492	1.237e-37	159.0	COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,2VJT7@28216|Betaproteobacteria,4ABSS@80864|Comamonadaceae	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
CMS3_k127_2772855_7	269799.Gmet_0559	6.53e-08	63.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD
CMS3_k127_2779048_0	909663.KI867150_gene2054	2.093e-86	293.0	COG2836@1|root,COG2836@2|Bacteria,1QVGG@1224|Proteobacteria,432GS@68525|delta/epsilon subdivisions,2WXZW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
CMS3_k127_2779048_1	313606.M23134_02341	1.431e-23	106.0	2EA12@1|root,3346D@2|Bacteria,4NWBJ@976|Bacteroidetes,47VPK@768503|Cytophagia	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
CMS3_k127_2792544_0	1191523.MROS_2663	0.0	1244.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	nifJ	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0016625,GO:0016903,GO:0043873,GO:0050896,GO:0055114	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iJN678.nifJ,iLF82_1304.LF82_2789,iNRG857_1313.NRG857_06920	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
CMS3_k127_2792544_1	1123392.AQWL01000005_gene3212	9.953e-09	65.0	COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,2VK6N@28216|Betaproteobacteria,1KSMP@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Dihydroorotate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DHO_dh
CMS3_k127_2792732_1	479434.Sthe_2091	1.172e-46	184.0	COG3857@1|root,COG3857@2|Bacteria	2|Bacteria	L	exonuclease activity	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
CMS3_k127_2792732_0	479434.Sthe_2092	5.079e-132	459.0	COG1074@1|root,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	-	-	3.1.11.5,3.1.12.1,3.6.4.12	ko:K01144,ko:K07464,ko:K16898	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
CMS3_k127_2828098_1	880072.Desac_0403	1.306e-75	264.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,42PE5@68525|delta/epsilon subdivisions,2WK7C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
CMS3_k127_2828098_0	1303518.CCALI_00297	8.108e-92	320.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
CMS3_k127_284688_2	1379698.RBG1_1C00001G0172	7.246e-35	142.0	COG1825@1|root,COG1825@2|Bacteria,2NPVU@2323|unclassified Bacteria	2|Bacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
CMS3_k127_284688_0	1379698.RBG1_1C00001G0643	2.881e-108	360.0	COG0462@1|root,COG0462@2|Bacteria,2NNP6@2323|unclassified Bacteria	2|Bacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2848	Pribosyl_synth,Pribosyltran_N
CMS3_k127_284688_1	1410665.JNKR01000024_gene70	8.667e-51	194.0	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,4H1VY@909932|Negativicutes	909932|Negativicutes	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
CMS3_k127_2863319_1	362418.IW19_06415	1.544e-19	96.0	COG2067@1|root,COG2067@2|Bacteria,4NE43@976|Bacteroidetes,1HZ3R@117743|Flavobacteriia,2NSNZ@237|Flavobacterium	976|Bacteroidetes	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2863319_0	1379698.RBG1_1C00001G1866	6.352e-87	298.0	COG2204@1|root,COG2204@2|Bacteria,2NQDH@2323|unclassified Bacteria	2|Bacteria	T	Sigma-54 interaction domain	fhlA	-	-	ko:K03413,ko:K13589	ko02020,ko02030,ko04112,map02020,map02030,map04112	M00506,M00512	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_2864611_1	635013.TherJR_1408	1.729e-16	91.0	COG1287@1|root,COG1287@2|Bacteria,1V7EF@1239|Firmicutes,24M0T@186801|Clostridia,265QD@186807|Peptococcaceae	186801|Clostridia	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2864611_0	1120972.AUMH01000012_gene21	8.236e-245	787.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,4HAW9@91061|Bacilli,2781C@186823|Alicyclobacillaceae	91061|Bacilli	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS3_k127_2877983_0	1123278.KB893411_gene2872	1.598e-58	230.0	COG3209@1|root,COG4932@1|root,COG3209@2|Bacteria,COG4932@2|Bacteria,4PKBQ@976|Bacteroidetes,47XXU@768503|Cytophagia	976|Bacteroidetes	M	SprB repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,SdrD_B,SprB
CMS3_k127_2877983_2	1197477.IA57_12525	2.632e-22	113.0	COG2304@1|root,COG4932@1|root,COG2304@2|Bacteria,COG4932@2|Bacteria,4NK3C@976|Bacteroidetes,1I0WF@117743|Flavobacteriia	976|Bacteroidetes	M	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2877983_1	335541.Swol_1116	3.007e-40	156.0	COG1401@1|root,COG1401@2|Bacteria,1TRK1@1239|Firmicutes,24BUZ@186801|Clostridia	186801|Clostridia	V	ATPase associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5,DUF3578
CMS3_k127_2903901_2	880073.Calab_3213	5.74e-14	87.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Arylsulfotrans,PQQ_2
CMS3_k127_2903901_1	1121101.HMPREF1532_03733	9.812e-110	402.0	COG1361@1|root,COG1520@1|root,COG4870@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG4870@2|Bacteria,4NVQ3@976|Bacteroidetes,2G321@200643|Bacteroidia,4ATRZ@815|Bacteroidaceae	976|Bacteroidetes	MO	Peptidase family C25	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25,VCBS
CMS3_k127_2903901_0	1379270.AUXF01000007_gene934	5.185e-206	654.0	COG0021@1|root,COG0021@2|Bacteria,1ZTA2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
CMS3_k127_2905030_4	1452536.JARE01000081_gene1151	2.404e-10	73.0	COG2247@1|root,COG3170@1|root,COG4932@1|root,COG2247@2|Bacteria,COG3170@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K14645,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_3_2,CW_binding_2,SLH
CMS3_k127_2905030_0	502025.Hoch_4734	6.712e-238	755.0	COG1164@1|root,COG1164@2|Bacteria,1Q3C4@1224|Proteobacteria,4393F@68525|delta/epsilon subdivisions,2X49B@28221|Deltaproteobacteria,2YYJ7@29|Myxococcales	28221|Deltaproteobacteria	E	Oligoendopeptidase f	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2905030_1	1333856.L686_04510	5.388e-161	518.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,1Z1JK@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	DinB superfamily	egtB	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
CMS3_k127_2905030_3	671143.DAMO_0398	5.853e-57	214.0	COG0316@1|root,COG0694@1|root,COG0316@2|Bacteria,COG0694@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	iscA	-	-	ko:K07400,ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn,Nfu_N,NifU
CMS3_k127_2905030_2	290397.Adeh_2440	2.779e-108	367.0	COG0151@1|root,COG0151@2|Bacteria,1NA76@1224|Proteobacteria,43CA7@68525|delta/epsilon subdivisions,2X7KS@28221|Deltaproteobacteria,2Z204@29|Myxococcales	28221|Deltaproteobacteria	F	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
CMS3_k127_2925786_1	1178825.ALIH01000011_gene42	0.0007278	51.0	2ED2B@1|root,336Z9@2|Bacteria,4NVY5@976|Bacteroidetes,1I5D3@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2925786_0	867903.ThesuDRAFT_02150	1.945e-31	137.0	COG1845@1|root,COG1845@2|Bacteria	2|Bacteria	C	cytochrome c oxidase, subunit III	coxO	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
CMS3_k127_2937086_0	1121422.AUMW01000001_gene2324	6.911e-17	84.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia	186801|Clostridia	KT	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_8,PAS,PAS_9,PrpR_N,Sigma54_activat
CMS3_k127_2937086_1	1005048.CFU_2703	2.692e-06	60.0	28M2S@1|root,2ZAH5@2|Bacteria,1MVH5@1224|Proteobacteria,2VM5E@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2946577_2	550540.Fbal_1133	1.167e-38	149.0	COG1472@1|root,COG1472@2|Bacteria,1QUPT@1224|Proteobacteria,1T20E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
CMS3_k127_2946577_0	349161.Dred_2488	1.332e-137	445.0	COG4864@1|root,COG4864@2|Bacteria,1TPTD@1239|Firmicutes,24APU@186801|Clostridia,260UQ@186807|Peptococcaceae	186801|Clostridia	S	UPF0365 protein	-	-	-	-	-	-	-	-	-	-	-	-	YdfA_immunity
CMS3_k127_2946577_1	945713.IALB_2104	4.208e-48	180.0	COG1030@1|root,COG1030@2|Bacteria	2|Bacteria	-	-	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD,Peptidase_S49,SDH_sah
CMS3_k127_2952539_0	1191523.MROS_2048	2.275e-32	138.0	COG0737@1|root,COG3303@1|root,COG0737@2|Bacteria,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	5_nucleotid_C,Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1,SBP_bac_8,SLH
CMS3_k127_2952539_1	215803.DB30_1421	1.641e-10	74.0	COG3005@1|root,COG3005@2|Bacteria,1QX4N@1224|Proteobacteria,43BXD@68525|delta/epsilon subdivisions,2X786@28221|Deltaproteobacteria,2Z3DX@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
CMS3_k127_2959158_1	935863.AWZR01000007_gene259	8.664e-19	90.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1X3XJ@135614|Xanthomonadales	1236|Gammaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm2	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CMS3_k127_2959158_0	502025.Hoch_2603	4.446e-125	415.0	COG0167@1|root,COG0479@1|root,COG0167@2|Bacteria,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	-	-	1.3.1.1,1.3.1.2,1.97.1.9	ko:K00207,ko:K12527,ko:K17723	ko00240,ko00410,ko00450,ko00770,ko00983,ko01100,map00240,map00410,map00450,map00770,map00983,map01100	M00046	R00977,R00978,R01414,R01415,R07229,R08226,R11026	RC00072,RC00123,RC02245,RC02420	ko00000,ko00001,ko00002,ko01000	-	-	-	ATC_hydrolase,CCG,DHO_dh,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_20,Fer4_8,Pyr_redox_2
CMS3_k127_2961229_0	1416760.AYMS01000040_gene818	5.651e-216	687.0	COG2978@1|root,COG2978@2|Bacteria,4NH64@976|Bacteroidetes,1I0S9@117743|Flavobacteriia	976|Bacteroidetes	H	AbgT putative transporter family	ydaH	-	-	ko:K12942	-	-	-	-	ko00000	-	-	-	ABG_transport
CMS3_k127_2961229_4	489825.LYNGBM3L_48360	2.615e-14	83.0	COG5505@1|root,COG5505@2|Bacteria,1G9X6@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF819
CMS3_k127_2961229_5	221288.JH992901_gene4048	0.0001516	48.0	COG0265@1|root,COG0265@2|Bacteria,1GQ2N@1117|Cyanobacteria	1117|Cyanobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
CMS3_k127_2961229_3	509635.N824_20655	3.466e-18	89.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,4NWGZ@976|Bacteroidetes,1IV92@117747|Sphingobacteriia	976|Bacteroidetes	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin,Trypsin_2
CMS3_k127_2961229_1	1380355.JNIJ01000046_gene1377	1.219e-133	434.0	28HGI@1|root,2Z7SC@2|Bacteria,1MWKC@1224|Proteobacteria,2TUQY@28211|Alphaproteobacteria,3JWHK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_2961229_2	886293.Sinac_1395	3.573e-28	118.0	COG3682@1|root,COG3682@2|Bacteria,2J0N4@203682|Planctomycetes	203682|Planctomycetes	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS3_k127_2981646_0	1267005.KB911265_gene3608	5.583e-305	944.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2TUPJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
CMS3_k127_2981646_1	871963.Desdi_0486	1.761e-17	85.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,2649C@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS3_k127_2997318_0	584708.Apau_0258	2.4e-31	142.0	COG4206@1|root,COG4206@2|Bacteria,3TA5R@508458|Synergistetes	508458|Synergistetes	H	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
CMS3_k127_2997318_1	1125863.JAFN01000001_gene2857	5.859e-21	101.0	COG3391@1|root,COG3391@2|Bacteria,1RJQF@1224|Proteobacteria,42VW9@68525|delta/epsilon subdivisions,2WRUS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3011369_2	1449126.JQKL01000022_gene152	8.945e-15	75.0	COG1752@1|root,COG1752@2|Bacteria,1UUVB@1239|Firmicutes,24HQS@186801|Clostridia,26BCB@186813|unclassified Clostridiales	186801|Clostridia	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
CMS3_k127_3011369_0	379066.GAU_2856	1.377e-167	552.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1ZT1A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Enoyl-CoA hydratase/isomerase	fadJ	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
CMS3_k127_3011369_1	1379698.RBG1_1C00001G0786	2.955e-135	443.0	COG0183@1|root,COG0183@2|Bacteria,2NQJA@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_3011369_3	1382315.JPOI01000001_gene1905	7.823e-07	60.0	COG3290@1|root,COG3829@1|root,COG3290@2|Bacteria,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,4HADT@91061|Bacilli,1WE9X@129337|Geobacillus	91061|Bacilli	KT	Bacterial regulatory protein, Fis family	bkdR	-	-	-	-	-	-	-	-	-	-	-	DapB_N,HTH_8,PAS,Sigma54_activat
CMS3_k127_3018273_0	518766.Rmar_0638	4.264e-257	823.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1FIMH@1100069|Bacteroidetes Order II. Incertae sedis	2|Bacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
CMS3_k127_3018273_3	1254432.SCE1572_22505	1.283e-157	517.0	COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_3018273_1	404589.Anae109_3623	1.179e-175	565.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42MBP@68525|delta/epsilon subdivisions,2WTMD@28221|Deltaproteobacteria,2YZR1@29|Myxococcales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
CMS3_k127_3018273_7	1286171.EAL2_808p06090	1.298e-30	138.0	COG3768@1|root,COG3768@2|Bacteria,1V39W@1239|Firmicutes,24GI5@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF697
CMS3_k127_3018273_4	1121920.AUAU01000003_gene1177	3.036e-85	295.0	2BVWN@1|root,33U5I@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3018273_5	756272.Plabr_0265	1.783e-83	297.0	COG2211@1|root,COG2211@2|Bacteria,2IY9C@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_3018273_2	518766.Rmar_2786	5.124e-162	520.0	COG2239@1|root,COG2239@2|Bacteria,4NGGN@976|Bacteroidetes,1FJBY@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	MgtE intracellular N domain	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
CMS3_k127_3035416_0	1121930.AQXG01000001_gene1203	9.496e-240	773.0	COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS3_k127_3035416_1	1123053.AUDG01000010_gene1553	2.343e-37	148.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS3_k127_3040305_1	1433126.BN938_1162	2.742e-59	223.0	COG3104@1|root,COG3104@2|Bacteria,4NIIT@976|Bacteroidetes,2FR16@200643|Bacteroidia	976|Bacteroidetes	E	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_3040305_0	234267.Acid_5036	3.856e-96	329.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	cya3	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8,Trans_reg_C
CMS3_k127_3060010_0	880073.Calab_1105	2.919e-64	250.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	ko:K17713,ko:K20952	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.33.1	-	-	Beta-prism_lec,PQQ_2,PQQ_3,Peptidase_S8,Pkinase,VCBS
CMS3_k127_3072776_4	1313304.CALK_1771	1.643e-19	92.0	COG0718@1|root,COG0718@2|Bacteria	2|Bacteria	S	YbaB/EbfC DNA-binding family	yaaK	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
CMS3_k127_3072776_1	446470.Snas_6148	2.165e-62	223.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4EXKR@85014|Glycomycetales	201174|Actinobacteria	L	RecR protein	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
CMS3_k127_3072776_2	379066.GAU_1115	2.731e-32	139.0	COG2018@1|root,COG2018@2|Bacteria,1ZTK7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Roadblock/LC7 domain	-	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
CMS3_k127_3072776_0	1278073.MYSTI_02214	8.166e-77	266.0	COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,2YU2F@29|Myxococcales	28221|Deltaproteobacteria	S	ADP-ribosylation factor family	mglA	GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,Ras
CMS3_k127_3072776_3	517417.Cpar_1697	6.616e-23	112.0	COG1267@1|root,COG1267@2|Bacteria,1FE6P@1090|Chlorobi	1090|Chlorobi	I	PFAM phosphatidylglycerophosphatase A	-	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
CMS3_k127_308668_3	1298867.AUES01000066_gene4694	2.046e-14	82.0	COG1287@1|root,COG1287@2|Bacteria,1N1IK@1224|Proteobacteria,2TUYH@28211|Alphaproteobacteria,3JSAB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_308668_1	706587.Desti_3787	6.161e-57	217.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,42R48@68525|delta/epsilon subdivisions,2WMAR@28221|Deltaproteobacteria,2MQMA@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	TIGRFAM MazG family protein	mazG	-	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
CMS3_k127_308668_2	448385.sce7551	1.188e-34	151.0	COG2885@1|root,COG2885@2|Bacteria,1R7WJ@1224|Proteobacteria,42QJK@68525|delta/epsilon subdivisions,2WJX0@28221|Deltaproteobacteria,2YWI7@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,TSP_3
CMS3_k127_308668_0	880073.Calab_2162	1.384e-60	216.0	COG1428@1|root,COG1428@2|Bacteria,2NR23@2323|unclassified Bacteria	2|Bacteria	F	Deoxynucleoside kinase	dck	-	-	-	-	-	-	-	-	-	-	-	dNK
CMS3_k127_3087583_0	886293.Sinac_2431	2.674e-43	164.0	COG2318@1|root,COG2318@2|Bacteria,2IZP2@203682|Planctomycetes	203682|Planctomycetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
CMS3_k127_3087583_1	234267.Acid_5354	7.433e-30	131.0	COG2204@1|root,COG2208@1|root,COG2204@2|Bacteria,COG2208@2|Bacteria,3Y49J@57723|Acidobacteria	57723|Acidobacteria	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
CMS3_k127_3087583_3	660470.Theba_1359	1.191e-07	63.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1700,DUF4097
CMS3_k127_3087583_4	356851.JOAN01000011_gene5404	0.0008779	52.0	COG5297@1|root,COG5297@2|Bacteria,2GMQN@201174|Actinobacteria,4DAAV@85008|Micromonosporales	201174|Actinobacteria	G	Endoglucanase	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_2,CBM_4_9,CelD_N,Glyco_hydro_9,I-set
CMS3_k127_3087583_2	1191523.MROS_1825	7.422e-15	89.0	COG4412@1|root,COG4447@1|root,COG4412@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF4859,FlgD_ig,PSII_BNR
CMS3_k127_3088066_0	1254432.SCE1572_37375	2.206e-156	508.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,42N8C@68525|delta/epsilon subdivisions,2WM3N@28221|Deltaproteobacteria,2YUFY@29|Myxococcales	28221|Deltaproteobacteria	K	AlkA N-terminal domain	-	-	3.2.2.21	ko:K13529,ko:K13530	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
CMS3_k127_3088066_2	1155718.KB891877_gene5318	1.499e-44	168.0	COG0350@1|root,COG0350@2|Bacteria,2IHXW@201174|Actinobacteria	201174|Actinobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	GO:0003674,GO:0003824,GO:0003908,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051409,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
CMS3_k127_3088066_1	926550.CLDAP_30940	3.131e-58	205.0	COG0076@1|root,COG0076@2|Bacteria,2G7N6@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28,4.1.2.27	ko:K01593,ko:K01634	ko00350,ko00360,ko00380,ko00600,ko00901,ko00950,ko00965,ko01100,ko01110,ko04071,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00600,map00901,map00950,map00965,map01100,map01110,map04071,map04726,map04728,map05030,map05031,map05034	M00037,M00042,M00100	R00685,R00699,R00736,R02080,R02464,R02701,R04909,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
CMS3_k127_3139731_1	1120972.AUMH01000017_gene690	6.339e-44	164.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,4HACY@91061|Bacilli,277VJ@186823|Alicyclobacillaceae	91061|Bacilli	O	Belongs to the ClpA ClpB family	clpC	GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
CMS3_k127_3139731_0	1379698.RBG1_1C00001G1846	4.444e-122	419.0	COG4775@1|root,COG4775@2|Bacteria,2NNNW@2323|unclassified Bacteria	2|Bacteria	M	Surface antigen	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
CMS3_k127_3142826_2	518766.Rmar_1770	1.466e-96	334.0	COG1131@1|root,COG1131@2|Bacteria,4NEH0@976|Bacteroidetes,1FJR1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	ABC transporter	gldA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_3142826_3	530564.Psta_0818	1.491e-49	190.0	COG3437@1|root,COG3437@2|Bacteria,2IXR5@203682|Planctomycetes	203682|Planctomycetes	T	metal-dependent phosphohydrolase HD sub domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Pkinase,Response_reg
CMS3_k127_3142826_1	861299.J421_0447	5.804e-97	324.0	COG2107@1|root,COG2107@2|Bacteria,1ZTVU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
CMS3_k127_3142826_0	665571.STHERM_c15920	1.807e-108	365.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
CMS3_k127_3181086_2	395493.BegalDRAFT_0025	8.369e-05	49.0	COG0607@1|root,COG0607@2|Bacteria,1R71B@1224|Proteobacteria,1S2D9@1236|Gammaproteobacteria,4637I@72273|Thiotrichales	72273|Thiotrichales	KP	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CMS3_k127_3181086_0	1089552.KI911559_gene814	1.198e-121	404.0	2CC5D@1|root,2ZAC9@2|Bacteria,1R5ZC@1224|Proteobacteria	1224|Proteobacteria	S	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase
CMS3_k127_3181086_1	1158609.I586_01058	1.319e-13	82.0	COG4932@1|root,COG5492@1|root,COG4932@2|Bacteria,COG5492@2|Bacteria,1V0GB@1239|Firmicutes	1239|Firmicutes	N	von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,SdrD_B,VWA,VWA_2
CMS3_k127_3194181_6	604331.AUHY01000038_gene132	1.203e-18	90.0	COG0438@1|root,COG0438@2|Bacteria,1WI3Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM Glycosyl transferase, group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_3194181_1	1163617.SCD_n00988	2.648e-172	546.0	COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,2VPZ0@28216|Betaproteobacteria	28216|Betaproteobacteria	G	deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
CMS3_k127_3194181_7	880073.Calab_2084	4.181e-12	80.0	COG2911@1|root,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C,FlgD_ig,Peptidase_S74
CMS3_k127_3194181_3	1379698.RBG1_1C00001G1831	4.412e-34	152.0	COG2706@1|root,COG4733@1|root,COG2706@2|Bacteria,COG4733@2|Bacteria,2NR81@2323|unclassified Bacteria	2|Bacteria	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	PKD,VCBS
CMS3_k127_3194181_2	382464.ABSI01000012_gene2139	2.199e-44	185.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,VPEP
CMS3_k127_3194181_0	1124780.ANNU01000008_gene2769	1.351e-255	805.0	COG1164@1|root,COG1164@2|Bacteria,4NJFW@976|Bacteroidetes,47TFT@768503|Cytophagia	976|Bacteroidetes	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
CMS3_k127_3194181_5	909663.KI867151_gene3027	3.545e-21	98.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria,2MS84@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	SMART Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CMS3_k127_3194181_4	1191523.MROS_0141	1.44e-31	139.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	waaC	-	-	ko:K02841,ko:K02843,ko:K12982	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS3_k127_3203571_2	879212.DespoDRAFT_01390	4.346e-05	56.0	COG0457@1|root,COG4235@1|root,COG0457@2|Bacteria,COG4235@2|Bacteria,1MXMD@1224|Proteobacteria,42NZK@68525|delta/epsilon subdivisions,2WIY5@28221|Deltaproteobacteria,2MJAV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8,zinc_ribbon_4
CMS3_k127_3203571_0	235909.GK1170	4.706e-174	569.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,4H9WW@91061|Bacilli,1WEMW@129337|Geobacillus	91061|Bacilli	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
CMS3_k127_3203571_1	981369.JQMJ01000004_gene2935	8.089e-22	96.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria,2NH5C@228398|Streptacidiphilus	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	resD	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_3204416_1	439235.Dalk_1426	6.567e-95	328.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,2MI1J@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
CMS3_k127_3204416_0	945713.IALB_1902	3.284e-128	428.0	COG0226@1|root,COG0226@2|Bacteria	2|Bacteria	P	phosphate ion binding	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
CMS3_k127_3204416_2	338963.Pcar_0656	4.425e-83	298.0	COG4590@1|root,COG4590@2|Bacteria,1QTTD@1224|Proteobacteria,43CG2@68525|delta/epsilon subdivisions,2X7R2@28221|Deltaproteobacteria,43S7A@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
CMS3_k127_3206336_0	335543.Sfum_3516	2.183e-251	787.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2MQTV@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C
CMS3_k127_3206336_1	1121405.dsmv_0256	3.418e-91	311.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42N2T@68525|delta/epsilon subdivisions,2WMYV@28221|Deltaproteobacteria,2MI58@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CMS3_k127_3239950_0	485913.Krac_8827	2.201e-72	261.0	COG2872@1|root,COG2872@2|Bacteria,2GA6P@200795|Chloroflexi	200795|Chloroflexi	S	Threonyl alanyl tRNA synthetase SAD	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
CMS3_k127_3239950_1	192875.XP_004346289.1	2.433e-44	170.0	COG0624@1|root,KOG2275@2759|Eukaryota,38BH3@33154|Opisthokonta	33154|Opisthokonta	E	peptidase activity	-	GO:0003674,GO:0003824,GO:0006508,GO:0006518,GO:0006575,GO:0006749,GO:0006751,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009636,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0042219,GO:0042221,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0070011,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1990748	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS3_k127_3294835_4	1499967.BAYZ01000181_gene4482	1.838e-24	109.0	COG1522@1|root,COG1522@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	lrp	GO:0000096,GO:0000098,GO:0000976,GO:0001067,GO:0001101,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006351,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006534,GO:0006551,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009059,GO:0009063,GO:0009069,GO:0009071,GO:0009078,GO:0009080,GO:0009081,GO:0009082,GO:0009093,GO:0009098,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016053,GO:0016054,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019752,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031334,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0043170,GO:0043200,GO:0043201,GO:0043254,GO:0043436,GO:0043565,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046394,GO:0046395,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901698,GO:1901700,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000144,GO:2001141	-	ko:K03719,ko:K05800,ko:K15782	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
CMS3_k127_3294835_0	1144275.COCOR_06542	1.19e-185	592.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,42N09@68525|delta/epsilon subdivisions,2WIRX@28221|Deltaproteobacteria,2YUYT@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_3294835_1	272123.Anacy_2819	6.192e-129	424.0	COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,1HJ2V@1161|Nostocales	1117|Cyanobacteria	C	PFAM Alanine dehydrogenase PNT, C-terminal domain	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
CMS3_k127_3294835_3	756067.MicvaDRAFT_5491	1.931e-28	129.0	COG3288@1|root,COG3288@2|Bacteria,1G711@1117|Cyanobacteria,1HBSG@1150|Oscillatoriales	1117|Cyanobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	pntA-2	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
CMS3_k127_3294835_2	221288.JH992901_gene2984	2.14e-45	171.0	COG1282@1|root,COG1282@2|Bacteria,1G2AX@1117|Cyanobacteria,1JHQ2@1189|Stigonemataceae	1117|Cyanobacteria	C	NAD(P) transhydrogenase beta subunit	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
CMS3_k127_329497_1	314230.DSM3645_09692	7.302e-29	124.0	COG1595@1|root,COG1595@2|Bacteria,2J08Y@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_329497_3	269798.CHU_0194	2.022e-08	66.0	COG1366@1|root,COG1366@2|Bacteria,4NT5G@976|Bacteroidetes,47RJ2@768503|Cytophagia	976|Bacteroidetes	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS3_k127_329497_2	945713.IALB_0016	5.625e-18	96.0	2EGEF@1|root,33A6F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_329497_4	1192868.CAIU01000040_gene4440	7.755e-08	59.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,43HGG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
CMS3_k127_329497_0	888727.HMPREF9092_0615	4.675e-43	161.0	COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,24JM2@186801|Clostridia,3WCJG@538999|Clostridiales incertae sedis	186801|Clostridia	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
CMS3_k127_330240_1	123899.JPQP01000019_gene2617	2.762e-11	68.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2VU93@28216|Betaproteobacteria,3T94M@506|Alcaligenaceae	28216|Betaproteobacteria	O	Thioredoxin	tlpA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
CMS3_k127_330240_0	1121957.ATVL01000014_gene1421	4.43e-47	184.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_3,Cellulase
CMS3_k127_3323760_2	1125863.JAFN01000001_gene2234	2.439e-07	53.0	COG1342@1|root,COG1342@2|Bacteria,1N80T@1224|Proteobacteria,42WDZ@68525|delta/epsilon subdivisions,2WSGS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function  DUF134	-	-	-	-	-	-	-	-	-	-	-	-	DUF134
CMS3_k127_3323760_0	331113.SNE_A06590	1.925e-48	190.0	COG4247@1|root,COG4247@2|Bacteria	2|Bacteria	I	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)	phy	-	3.1.3.8	ko:K01083	ko00562,map00562	-	R03371	RC00078	ko00000,ko00001,ko01000	-	-	-	NHL,Phytase
CMS3_k127_3323760_1	1158294.JOMI01000003_gene2250	1.888e-12	73.0	COG1216@1|root,COG1216@2|Bacteria,4P1S5@976|Bacteroidetes,2FX1U@200643|Bacteroidia	976|Bacteroidetes	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3342228_0	1125863.JAFN01000001_gene2450	4.387e-196	619.0	COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,42N5K@68525|delta/epsilon subdivisions,2WK1G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase isomerase	bamA	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788	3.7.1.21	ko:K07539	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05593,R05594,R10696	RC01430,RC01431,RC03237	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_3342228_5	1191523.MROS_1655	1.048e-13	83.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,HisKA_7TM,Hpt,PMT_2,Response_reg
CMS3_k127_3342228_4	483219.LILAB_28620	9.136e-21	102.0	COG1595@1|root,COG1595@2|Bacteria,1Q4ZI@1224|Proteobacteria,42TYH@68525|delta/epsilon subdivisions,2WQNG@28221|Deltaproteobacteria,2YYP8@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	carQ	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_3342228_3	1096769.Pelub83DRAFT_0415	1.98e-22	100.0	2FDFA@1|root,345GY@2|Bacteria,1P1RR@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3342228_1	1242864.D187_000932	1.305e-83	300.0	COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria	1224|Proteobacteria	G	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
CMS3_k127_3342228_2	1121104.AQXH01000001_gene1400	5.046e-34	139.0	COG0624@1|root,COG0624@2|Bacteria,4NEA7@976|Bacteroidetes,1IWTY@117747|Sphingobacteriia	976|Bacteroidetes	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_337631_3	706587.Desti_2514	1.584e-09	62.0	COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DEAD DEAH box helicase	yprA	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C,RNase_H_2
CMS3_k127_337631_1	1173029.JH980292_gene2124	1.065e-33	150.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298,PMT,PMT_2
CMS3_k127_337631_0	1206741.BAFX01000183_gene7620	1.56e-114	385.0	COG0438@1|root,COG0438@2|Bacteria,2GSQI@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
CMS3_k127_337631_2	562970.Btus_1333	5.414e-27	117.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,4HBG2@91061|Bacilli,2782F@186823|Alicyclobacillaceae	91061|Bacilli	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS3_k127_3385271_3	472759.Nhal_1379	5.323e-32	128.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1S0BH@1236|Gammaproteobacteria,1X076@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
CMS3_k127_3385271_2	309807.SRU_1523	1.913e-38	150.0	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,4NFWN@976|Bacteroidetes,1FINF@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	OsmC-like protein	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4,OsmC
CMS3_k127_3385271_0	1117315.AHCA01000009_gene456	1.519e-189	626.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RYP9@1236|Gammaproteobacteria,2PZTK@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	ERAP1-like C-terminal domain	-	-	3.4.11.14,3.4.11.2	ko:K01256,ko:K01263	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
CMS3_k127_3385271_4	644282.Deba_1057	3.141e-10	66.0	COG0745@1|root,COG0745@2|Bacteria,1N3R6@1224|Proteobacteria,42TU3@68525|delta/epsilon subdivisions,2WQ9W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS3_k127_3385271_1	945713.IALB_0461	1.799e-41	161.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	aprN	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CMS3_k127_3393147_0	1379698.RBG1_1C00001G1725	0.0	1384.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrD	-	-	ko:K03296,ko:K18138,ko:K18307	ko01501,ko01503,ko02024,map01501,map01503,map02024	M00644,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.20,2.A.6.2.32	-	-	ACR_tran
CMS3_k127_3393147_1	1379698.RBG1_1C00001G1724	1.272e-109	366.0	COG0845@1|root,COG0845@2|Bacteria,2NR7K@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	mdtA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
CMS3_k127_3393147_2	1340493.JNIF01000003_gene2324	1.162e-14	87.0	COG1538@1|root,COG1538@2|Bacteria,3Y7Q2@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS3_k127_3398311_0	570952.ATVH01000002_gene953	2.082e-89	313.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,2JPB5@204441|Rhodospirillales	204441|Rhodospirillales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
CMS3_k127_3398311_2	1499967.BAYZ01000008_gene5426	3.354e-56	211.0	COG0324@1|root,COG0324@2|Bacteria,2NP6D@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
CMS3_k127_3398311_3	1158318.ATXC01000001_gene948	2.99e-05	48.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,TonB_2,TonB_C
CMS3_k127_3398311_1	1121413.JMKT01000012_gene575	3.644e-61	214.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2WK5J@28221|Deltaproteobacteria,2M9C6@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS3_k127_3408433_0	441620.Mpop_1587	5.674e-117	389.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria,1JT64@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
CMS3_k127_3408433_1	379066.GAU_1412	3.433e-05	48.0	COG0457@1|root,COG0457@2|Bacteria,1ZSPN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,TPR_16,TPR_2
CMS3_k127_3422962_0	595460.RRSWK_01304	1.079e-124	403.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2IYB9@203682|Planctomycetes	203682|Planctomycetes	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,GDC-P
CMS3_k127_3422962_1	1121930.AQXG01000023_gene1641	0.0001148	55.0	COG3209@1|root,COG3209@2|Bacteria,4P5ZD@976|Bacteroidetes	976|Bacteroidetes	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3425657_1	745411.B3C1_09697	1.677e-15	85.0	2DBWE@1|root,2ZBGD@2|Bacteria,1R6MH@1224|Proteobacteria,1SP99@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3425657_0	338966.Ppro_2250	1.378e-51	188.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,43TGS@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
CMS3_k127_3432632_3	1219375.CM002139_gene4107	1.878e-19	93.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,1X4H7@135614|Xanthomonadales	135614|Xanthomonadales	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
CMS3_k127_3432632_2	309807.SRU_0528	2.568e-24	114.0	COG1521@1|root,COG1521@2|Bacteria,4NE9E@976|Bacteroidetes,1FJDU@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
CMS3_k127_3432632_1	671143.DAMO_2458	1.97e-35	138.0	COG0234@1|root,COG0234@2|Bacteria,2NPW2@2323|unclassified Bacteria	2|Bacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
CMS3_k127_3432632_0	379066.GAU_1536	2.378e-237	743.0	COG0459@1|root,COG0459@2|Bacteria,1ZTC5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS3_k127_3438686_4	329726.AM1_1742	7.496e-90	304.0	COG4313@1|root,COG4313@2|Bacteria,1G150@1117|Cyanobacteria	1117|Cyanobacteria	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
CMS3_k127_3438686_2	96561.Dole_1419	4.803e-125	415.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42MH7@68525|delta/epsilon subdivisions,2WK12@28221|Deltaproteobacteria,2MIA2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Electron transfer flavoprotein alpha	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
CMS3_k127_3438686_3	1121396.KB893101_gene477	1.664e-110	368.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42PYM@68525|delta/epsilon subdivisions,2WJ37@28221|Deltaproteobacteria,2MIP8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
CMS3_k127_3438686_0	933262.AXAM01000018_gene1017	9.715e-287	895.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42MIV@68525|delta/epsilon subdivisions,2WJ5X@28221|Deltaproteobacteria,2MIC5@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,Fer4_9
CMS3_k127_3438686_1	1121405.dsmv_2196	1.374e-251	792.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42MUH@68525|delta/epsilon subdivisions,2WJ16@28221|Deltaproteobacteria,2MJ7S@213118|Desulfobacterales	28221|Deltaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
CMS3_k127_3461220_3	382464.ABSI01000010_gene3558	2.374e-81	286.0	COG1668@1|root,COG1668@2|Bacteria	2|Bacteria	CP	transmembrane transport	natB	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
CMS3_k127_3461220_2	382464.ABSI01000010_gene3557	1.518e-103	346.0	COG4152@1|root,COG4152@2|Bacteria	2|Bacteria	S	ATPase activity	natA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS3_k127_3461220_0	378806.STAUR_1666	2.199e-158	507.0	2C57D@1|root,2Z7RS@2|Bacteria,1MX6G@1224|Proteobacteria,42Y78@68525|delta/epsilon subdivisions,2X3CW@28221|Deltaproteobacteria,2YUS0@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2891
CMS3_k127_3461220_4	240015.ACP_2973	9.917e-09	64.0	COG1366@1|root,COG1366@2|Bacteria,3Y4U6@57723|Acidobacteria,2JJH2@204432|Acidobacteriia	204432|Acidobacteriia	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS3_k127_3461220_1	929556.Solca_4204	1.578e-127	422.0	COG1538@1|root,COG1538@2|Bacteria,4NDZK@976|Bacteroidetes,1IRJE@117747|Sphingobacteriia	976|Bacteroidetes	MU	TIGRFAM efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family	-	-	-	ko:K18139,ko:K18300	ko01501,ko02024,map01501,map02024	M00641,M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
CMS3_k127_3468217_3	1118054.CAGW01000071_gene1806	3.194e-07	55.0	COG2120@1|root,COG2120@2|Bacteria,1TV10@1239|Firmicutes,4HFJQ@91061|Bacilli,26RWT@186822|Paenibacillaceae	91061|Bacilli	S	deacetylase	bshB1	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
CMS3_k127_3468217_0	1379698.RBG1_1C00001G1765	2.47e-108	366.0	COG0438@1|root,COG0438@2|Bacteria,2NNTN@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	bshA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_3468217_4	585530.HMPREF0183_0198	8.014e-06	57.0	COG0737@1|root,COG0737@2|Bacteria,2GKC3@201174|Actinobacteria,4F9D0@85019|Brevibacteriaceae	201174|Actinobacteria	F	5'-nucleotidase, C-terminal domain	cpdB	-	3.1.3.5,3.1.3.6,3.1.4.16	ko:K01081,ko:K01119	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
CMS3_k127_3468217_1	530564.Psta_3995	9.397e-52	190.0	COG1403@1|root,COG1403@2|Bacteria,2IXXW@203682|Planctomycetes	203682|Planctomycetes	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
CMS3_k127_3468217_2	797299.HALLA_04925	5.579e-36	150.0	COG1893@1|root,arCOG04139@2157|Archaea,2XTBD@28890|Euryarchaeota,23T98@183963|Halobacteria	183963|Halobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
CMS3_k127_3471808_1	204669.Acid345_2243	5.044e-84	295.0	COG0436@1|root,COG0436@2|Bacteria,3Y3DG@57723|Acidobacteria,2JMAM@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS3_k127_3471808_0	877414.ATWA01000048_gene1895	3.478e-120	401.0	COG0498@1|root,COG0498@2|Bacteria,1TP25@1239|Firmicutes,25B08@186801|Clostridia,2686W@186813|unclassified Clostridiales	186801|Clostridia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_3471808_2	511051.CSE_09040	4.138e-22	102.0	COG0402@1|root,COG0402@2|Bacteria	2|Bacteria	F	S-adenosylhomocysteine deaminase activity	ssnA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS3_k127_3476718_2	926562.Oweho_1918	5.074e-05	55.0	2CIBF@1|root,2Z85N@2|Bacteria,4NF0J@976|Bacteroidetes,1HYX2@117743|Flavobacteriia,2PA9Q@246874|Cryomorphaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3476718_0	945713.IALB_2658	1.305e-28	125.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_3476718_1	502025.Hoch_6401	7.001e-09	67.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	-	-	-	ko:K03496,ko:K22491	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	B12-binding_2,DUF3967,HTH_17,MerR_1
CMS3_k127_3505389_2	765420.OSCT_1742	0.0004987	51.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_3505389_0	861299.J421_4356	1.512e-73	254.0	COG1136@1|root,COG1136@2|Bacteria,1ZUKE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_3505389_1	861299.J421_4355	4.007e-70	266.0	2AETJ@1|root,314QN@2|Bacteria,1ZU8F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3514041_2	105420.BBPO01000035_gene493	2.019e-08	59.0	COG5653@1|root,COG5653@2|Bacteria,2GXY9@201174|Actinobacteria,2NFBA@228398|Streptacidiphilus	201174|Actinobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
CMS3_k127_3514041_1	1121448.DGI_2106	2.542e-21	106.0	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,42UKB@68525|delta/epsilon subdivisions,2WQD0@28221|Deltaproteobacteria,2MDAN@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
CMS3_k127_3514041_0	443143.GM18_1632	8.46e-25	112.0	2ART5@1|root,31H4G@2|Bacteria,1R86P@1224|Proteobacteria,43DJP@68525|delta/epsilon subdivisions,2X8QY@28221|Deltaproteobacteria,43VV9@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3548130_2	290397.Adeh_1117	1.691e-12	73.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,42USC@68525|delta/epsilon subdivisions,2WQMY@28221|Deltaproteobacteria,2Z2ZG@29|Myxococcales	28221|Deltaproteobacteria	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS3_k127_3548130_1	502025.Hoch_0369	5.899e-34	146.0	COG2340@1|root,COG2340@2|Bacteria,1REVB@1224|Proteobacteria,4386P@68525|delta/epsilon subdivisions,2X3GI@28221|Deltaproteobacteria,2YW01@29|Myxococcales	28221|Deltaproteobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
CMS3_k127_3548130_0	880073.Calab_0603	2.859e-59	208.0	COG0438@1|root,COG0438@2|Bacteria,2NQ20@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_3555029_1	314230.DSM3645_20072	6.757e-77	262.0	COG0056@1|root,COG0056@2|Bacteria,2IXN5@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
CMS3_k127_3555029_2	886293.Sinac_6879	4.475e-73	256.0	COG0224@1|root,COG0224@2|Bacteria,2IXDI@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
CMS3_k127_3555029_0	565034.BHWA1_00203	5.052e-153	489.0	COG0055@1|root,COG0055@2|Bacteria,2J6GD@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
CMS3_k127_3570405_1	634498.mru_0145	1.11e-38	152.0	COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,23P0H@183925|Methanobacteria	183925|Methanobacteria	O	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
CMS3_k127_3570405_0	1499967.BAYZ01000103_gene3745	2.406e-56	225.0	COG0013@1|root,COG0013@2|Bacteria,2NPQB@2323|unclassified Bacteria	2|Bacteria	J	Threonyl and Alanyl tRNA synthetase second additional domain	alaS_2	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
CMS3_k127_3594999_1	946077.W5A_03249	3.045e-09	69.0	COG0457@1|root,COG0457@2|Bacteria,4NE2V@976|Bacteroidetes,1HWRP@117743|Flavobacteriia	976|Bacteroidetes	S	FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_6,TPR_8
CMS3_k127_3594999_0	880073.Calab_1878	2.066e-170	545.0	2CD20@1|root,2Z7SQ@2|Bacteria,2NNUF@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3610147_2	880073.Calab_3296	3.932e-15	89.0	COG0737@1|root,COG0737@2|Bacteria	2|Bacteria	F	nucleotide catabolic process	-	-	3.4.17.18	ko:K05996	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	5_nucleotid_C,Cytochrome_C554,SBP_bac_8,SLH
CMS3_k127_3610147_1	1379698.RBG1_1C00001G1377	6.223e-26	124.0	COG4409@1|root,COG4409@2|Bacteria,2NRD7@2323|unclassified Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase
CMS3_k127_3610147_0	1197130.BAFM01000012_gene2204	5.039e-235	779.0	arCOG02903@1|root,arCOG03612@1|root,arCOG02903@2157|Archaea,arCOG03612@2157|Archaea	2157|Archaea	P	PhoD-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Big_1,DUF1573,PKD,VWA
CMS3_k127_3613923_0	1121918.ARWE01000001_gene3644	2.102e-57	218.0	COG0500@1|root,COG0500@2|Bacteria,1QW86@1224|Proteobacteria,42N1Q@68525|delta/epsilon subdivisions,2WJJS@28221|Deltaproteobacteria,43TSG@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
CMS3_k127_362293_2	1380394.JADL01000013_gene680	5.591e-68	238.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,2JVT5@204441|Rhodospirillales	204441|Rhodospirillales	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2,5.3.1.9	ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	PGI,TAL_FSA
CMS3_k127_362293_0	215803.DB30_2856	3.942e-227	715.0	COG0304@1|root,COG0304@2|Bacteria,1Q3B2@1224|Proteobacteria,43927@68525|delta/epsilon subdivisions,2X47V@28221|Deltaproteobacteria,2YYFV@29|Myxococcales	28221|Deltaproteobacteria	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS3_k127_362293_1	504472.Slin_5436	7.976e-131	443.0	COG3172@1|root,COG3172@2|Bacteria,4NEQF@976|Bacteroidetes,47KCU@768503|Cytophagia	976|Bacteroidetes	H	Domain of unknown function (DUF4301)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4301
CMS3_k127_362293_3	1121403.AUCV01000002_gene474	3.752e-43	161.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	hom	-	1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00570	R00220,R00996,R01513,R01773,R01775	RC00031,RC00087,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3
CMS3_k127_3625281_3	1238182.C882_1820	1.77e-31	128.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2U5FM@28211|Alphaproteobacteria,2JRTE@204441|Rhodospirillales	204441|Rhodospirillales	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
CMS3_k127_3625281_0	264732.Moth_0703	1.398e-100	340.0	COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,249C5@186801|Clostridia,42I51@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
CMS3_k127_3625281_1	868595.Desca_0705	1.512e-38	156.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia,261RD@186807|Peptococcaceae	186801|Clostridia	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
CMS3_k127_3625281_2	1192034.CAP_4484	4.41e-37	160.0	COG1621@1|root,COG1807@1|root,COG1621@2|Bacteria,COG1807@2|Bacteria,1NPGH@1224|Proteobacteria,4322Q@68525|delta/epsilon subdivisions,2WWF0@28221|Deltaproteobacteria,2YVRQ@29|Myxococcales	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3636578_1	331678.Cphamn1_1502	2.195e-40	157.0	COG2318@1|root,COG2318@2|Bacteria,1FF6X@1090|Chlorobi	1090|Chlorobi	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS3_k127_3636578_0	672.VV93_v1c17940	5.445e-43	168.0	COG1874@1|root,COG1874@2|Bacteria,1PBWS@1224|Proteobacteria,1RYV8@1236|Gammaproteobacteria,1XWI1@135623|Vibrionales	135623|Vibrionales	G	Domain of unknown function (DUF4832)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4832,Glyco_hydro_42
CMS3_k127_3637185_4	671143.DAMO_0483	4.399e-29	126.0	COG3222@1|root,COG3222@2|Bacteria,2NRHT@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
CMS3_k127_3637185_2	709991.Odosp_3286	5.649e-59	230.0	COG0534@1|root,COG0534@2|Bacteria,4NHCU@976|Bacteroidetes,2FMEH@200643|Bacteroidia,22VWJ@171551|Porphyromonadaceae	976|Bacteroidetes	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS3_k127_3637185_0	880073.Calab_1920	1.152e-78	275.0	COG1801@1|root,COG1801@2|Bacteria,2NPDU@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
CMS3_k127_3637185_3	880073.Calab_2740	4.2e-35	136.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
CMS3_k127_3637185_1	1120973.AQXL01000119_gene533	7.278e-70	252.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,4HADJ@91061|Bacilli,279NS@186823|Alicyclobacillaceae	91061|Bacilli	L	IMS family HHH motif	dinB	GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0050896	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
CMS3_k127_3637185_5	880073.Calab_2038	1.391e-15	81.0	2DEXR@1|root,2ZPPS@2|Bacteria,2NRXB@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3650153_1	246197.MXAN_2663	7.38e-141	465.0	COG2271@1|root,COG2271@2|Bacteria,1MX4V@1224|Proteobacteria,42QEQ@68525|delta/epsilon subdivisions,2WQEB@28221|Deltaproteobacteria,2YTVI@29|Myxococcales	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	glp	-	-	ko:K02445	-	-	-	-	ko00000,ko02000	2.A.1.4.3	-	-	MFS_1
CMS3_k127_3650153_5	314230.DSM3645_12431	7.638e-35	136.0	COG3070@1|root,COG3070@2|Bacteria,2J0Y3@203682|Planctomycetes	203682|Planctomycetes	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
CMS3_k127_3650153_3	485913.Krac_4681	1.7e-59	218.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	dcsG	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP
CMS3_k127_3650153_0	1121920.AUAU01000012_gene2698	9.878e-254	805.0	COG0308@1|root,COG0308@2|Bacteria,3Y2XM@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Leuk-A4-hydro_C,Peptidase_M1
CMS3_k127_3650153_4	1121920.AUAU01000006_gene301	3.595e-49	182.0	2BYAB@1|root,32R2Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3650153_2	314285.KT71_03277	5.6e-93	317.0	COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,1SM0B@1236|Gammaproteobacteria,1J7TW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3656744_1	926569.ANT_29620	4.711e-28	120.0	COG1180@1|root,COG1180@2|Bacteria,2G6B2@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS3_k127_3656744_0	608538.HTH_0254	2.914e-35	143.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	sscB	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
CMS3_k127_3656744_2	1317124.DW2_17180	0.0003054	51.0	COG0438@1|root,COG0438@2|Bacteria,1P8MT@1224|Proteobacteria,2TRKC@28211|Alphaproteobacteria,2XM2M@285107|Thioclava	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_3658421_2	679926.Mpet_0551	2.381e-81	277.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
CMS3_k127_3658421_0	420247.Msm_1561	7.445e-136	441.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,23NSI@183925|Methanobacteria	183925|Methanobacteria	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
CMS3_k127_3658421_1	518766.Rmar_2195	7.608e-118	388.0	COG0320@1|root,COG0320@2|Bacteria,4NEB5@976|Bacteroidetes,1FIV9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
CMS3_k127_3658421_3	1192034.CAP_4484	2.287e-58	224.0	COG1621@1|root,COG1807@1|root,COG1621@2|Bacteria,COG1807@2|Bacteria,1NPGH@1224|Proteobacteria,4322Q@68525|delta/epsilon subdivisions,2WWF0@28221|Deltaproteobacteria,2YVRQ@29|Myxococcales	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3658421_4	635013.TherJR_1892	0.0002252	49.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_3661443_0	1124780.ANNU01000036_gene34	1.323e-285	898.0	COG0531@1|root,COG0531@2|Bacteria,4NFFX@976|Bacteroidetes,47M9P@768503|Cytophagia	976|Bacteroidetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease
CMS3_k127_3674571_2	880073.Calab_0773	1.129e-54	198.0	COG0449@1|root,COG0449@2|Bacteria,2NNWC@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
CMS3_k127_3674571_0	1379698.RBG1_1C00001G0687	1.089e-116	391.0	COG1109@1|root,COG1109@2|Bacteria,2NNM3@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	glmM	-	5.4.2.10,5.4.2.2,5.4.2.8	ko:K01840,ko:K03431,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R02060,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS3_k127_3674571_1	635013.TherJR_1499	2.642e-79	276.0	COG2199@1|root,COG3706@2|Bacteria,1UHZ8@1239|Firmicutes,25E7W@186801|Clostridia	186801|Clostridia	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
CMS3_k127_3679278_3	768671.ThimaDRAFT_3128	1.413e-08	64.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RZRG@1236|Gammaproteobacteria,1WVXI@135613|Chromatiales	135613|Chromatiales	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_3679278_0	234267.Acid_4515	1.787e-92	313.0	COG1131@1|root,COG1131@2|Bacteria,3Y6FZ@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_3679278_1	880073.Calab_2471	4.577e-51	192.0	COG1277@1|root,COG1277@2|Bacteria,2NPGK@2323|unclassified Bacteria	2|Bacteria	S	ABC-2 family transporter protein	yxlG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
CMS3_k127_3679278_2	1499967.BAYZ01000095_gene4168	5.09e-33	137.0	COG3225@1|root,COG3225@2|Bacteria,2NNVN@2323|unclassified Bacteria	2|Bacteria	N	ABC-type uncharacterized transport system	gldG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC_transp_aux
CMS3_k127_3683338_1	1162668.LFE_0249	3.032e-25	113.0	COG0607@1|root,COG0607@2|Bacteria,3J17U@40117|Nitrospirae	40117|Nitrospirae	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CMS3_k127_3683338_2	575540.Isop_0265	8.055e-10	66.0	COG1872@1|root,COG1872@2|Bacteria,2J1ES@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
CMS3_k127_3683338_0	530564.Psta_3616	5.641e-227	722.0	COG0243@1|root,COG0243@2|Bacteria,2IXVV@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
CMS3_k127_3684212_2	1279019.ARQK01000058_gene747	1.538e-90	313.0	COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,1T2GI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1,1.8.5.3	ko:K00370,ko:K07306,ko:K17050	ko00910,ko00920,ko01120,ko02020,map00910,map00920,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497,R09501	RC02555,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.3,5.A.3.8	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
CMS3_k127_3684212_3	234267.Acid_3506	2.762e-37	160.0	COG2010@1|root,COG2010@2|Bacteria,3Y5X3@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,FixO
CMS3_k127_3684212_0	1125863.JAFN01000001_gene2794	1.216e-195	629.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WMNX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cytochrome b b6 domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
CMS3_k127_3684212_4	1125863.JAFN01000001_gene2795	1.149e-30	136.0	COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42VKD@68525|delta/epsilon subdivisions,2WRHY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Rieske 2Fe-2S domain	pcmE	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
CMS3_k127_3684212_1	1125863.JAFN01000001_gene2796	9.585e-95	325.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42PJ7@68525|delta/epsilon subdivisions,2WMEM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
CMS3_k127_3697382_1	479434.Sthe_1838	2.836e-90	309.0	COG0448@1|root,COG0448@2|Bacteria,2G66Q@200795|Chloroflexi,27XFC@189775|Thermomicrobia	189775|Thermomicrobia	H	Nucleotidyl transferase	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
CMS3_k127_3697382_0	880073.Calab_3649	3.876e-94	332.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2NP1D@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase SLT domain	CP_0155	-	-	ko:K08307,ko:K12204	-	-	-	-	ko00000,ko01000,ko01011,ko02044	3.A.7.10.1,3.A.7.9.1	-	-	LysM,SLT,T4SS_TraI
CMS3_k127_3697382_2	926560.KE387023_gene1893	1.318e-33	147.0	COG2199@1|root,COG3706@2|Bacteria,1WI95@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	TIGRFAM diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HisKA_7TM,PAS_4
CMS3_k127_3707053_1	1127673.GLIP_0967	2.281e-24	108.0	COG1680@1|root,COG1680@2|Bacteria,1RIU7@1224|Proteobacteria	1224|Proteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS3_k127_3707053_2	309807.SRU_0566	3.561e-18	93.0	2ESEN@1|root,33JZB@2|Bacteria,4NZ9T@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3707053_0	1191523.MROS_2451	4.604e-139	449.0	COG0332@1|root,COG0332@2|Bacteria	2|Bacteria	I	beta-ketoacyl-acyl-carrier-protein synthase III activity	fabH	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0071704	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS3_k127_3708464_1	1121930.AQXG01000004_gene2843	5.197e-08	55.0	COG0737@1|root,COG2356@1|root,COG0737@2|Bacteria,COG2356@2|Bacteria,4PPNB@976|Bacteroidetes,1IY1S@117747|Sphingobacteriia	976|Bacteroidetes	F	Belongs to the 5'-nucleotidase family	-	-	-	-	-	-	-	-	-	-	-	-	LTD
CMS3_k127_3708464_0	880073.Calab_3359	3.24e-15	89.0	COG4632@1|root,COG4632@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,Metallophos,NAGPA,Polysacc_deac_1,SLH
CMS3_k127_3713796_0	1051632.TPY_1321	5.771e-197	627.0	COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,249W6@186801|Clostridia	186801|Clostridia	F	PFAM amidohydrolase	hydA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
CMS3_k127_3713796_2	240015.ACP_3154	1.887e-09	70.0	COG1664@1|root,COG1664@2|Bacteria,3Y5MK@57723|Acidobacteria,2JJXQ@204432|Acidobacteriia	204432|Acidobacteriia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
CMS3_k127_3713796_1	404589.Anae109_1720	2.07e-70	245.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,42N2B@68525|delta/epsilon subdivisions,2WJS9@28221|Deltaproteobacteria,2YVFZ@29|Myxococcales	28221|Deltaproteobacteria	S	Major facilitator	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
CMS3_k127_3727593_2	1121438.JNJA01000022_gene430	2.432e-55	205.0	COG4961@1|root,COG4961@2|Bacteria,1NIG7@1224|Proteobacteria,42X7K@68525|delta/epsilon subdivisions,2WSKV@28221|Deltaproteobacteria,2M9N1@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
CMS3_k127_3727593_4	404380.Gbem_1834	5.767e-50	194.0	COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,42QEH@68525|delta/epsilon subdivisions,2WKVC@28221|Deltaproteobacteria,43SJ6@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Flp pilus polar localization response receiver ATPase TadZ, FlhG domain-containing	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ,ParA,Response_reg
CMS3_k127_3727593_0	279714.FuraDRAFT_0828	1.198e-163	527.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2VJWJ@28216|Betaproteobacteria,2KTWA@206351|Neisseriales	206351|Neisseriales	U	Type II/IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
CMS3_k127_3727593_3	29581.BW37_01876	3.396e-50	190.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2VJ80@28216|Betaproteobacteria,4751W@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Type II secretion system (T2SS), protein F	tadB	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
CMS3_k127_3727593_1	279714.FuraDRAFT_0830	1.355e-58	216.0	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2VIA4@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Type II secretion system	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
CMS3_k127_3741630_0	1189612.A33Q_0360	3.094e-51	205.0	COG0389@1|root,COG0389@2|Bacteria,4NE9N@976|Bacteroidetes,47JI6@768503|Cytophagia	976|Bacteroidetes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
CMS3_k127_3741630_1	1283299.AUKG01000002_gene4280	3.382e-43	166.0	COG1974@1|root,COG1974@2|Bacteria,2GMBN@201174|Actinobacteria,4CQK7@84995|Rubrobacteria	84995|Rubrobacteria	K	LexA DNA binding domain	-	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
CMS3_k127_3741630_2	358396.C445_20845	4.532e-13	74.0	COG4274@1|root,arCOG01119@2157|Archaea,2Y0W5@28890|Euryarchaeota,23XG3@183963|Halobacteria	183963|Halobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
CMS3_k127_3741630_3	46681.XP_001740279.1	8.561e-13	80.0	298CG@1|root,2RF28@2759|Eukaryota,3XE7N@554915|Amoebozoa	554915|Amoebozoa	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_3744247_0	706587.Desti_5065	2.069e-75	259.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2MRKV@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM response regulator receiver	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_3744247_1	861299.J421_3830	8.391e-05	54.0	COG2856@1|root,COG2856@2|Bacteria,1ZSXU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3762319_0	871963.Desdi_2783	8.724e-105	355.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,248U7@186801|Clostridia,261AX@186807|Peptococcaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
CMS3_k127_3762319_1	345219.Bcoa_2272	9.522e-41	169.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli,1ZGG0@1386|Bacillus	91061|Bacilli	E	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate	gcvH	GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
CMS3_k127_3762319_2	319225.Plut_1329	5.126e-17	87.0	COG0095@1|root,COG0095@2|Bacteria,1FDZ6@1090|Chlorobi	1090|Chlorobi	H	PFAM biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
CMS3_k127_3772775_0	479434.Sthe_1906	4.94e-104	348.0	COG1200@1|root,COG1200@2|Bacteria,2G5YM@200795|Chloroflexi,27XT4@189775|Thermomicrobia	189775|Thermomicrobia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
CMS3_k127_3772775_2	861299.J421_3210	5.17e-15	86.0	2F3JX@1|root,33WDB@2|Bacteria,1ZTZI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_4
CMS3_k127_3772775_1	1121380.JNIW01000041_gene783	9.688e-49	179.0	COG1100@1|root,COG1100@2|Bacteria,1WJAD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
CMS3_k127_3776577_1	1379698.RBG1_1C00001G0356	7.254e-77	274.0	COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,2NS3S@2323|unclassified Bacteria	2|Bacteria	EG	Protein of unknown function (DUF2723)	-	-	-	ko:K16928	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.33	-	-	DUF2723,QueT
CMS3_k127_3776577_3	118173.KB235914_gene4082	2.005e-16	91.0	COG0392@1|root,COG0392@2|Bacteria,1G41A@1117|Cyanobacteria,1HD8Q@1150|Oscillatoriales	1117|Cyanobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS3_k127_3776577_0	861299.J421_3119	3.228e-89	318.0	COG0438@1|root,COG0438@2|Bacteria,1ZTBC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_3776577_2	59374.Fisuc_0695	5.172e-60	218.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
CMS3_k127_3782767_3	292459.STH2950	6.781e-29	120.0	COG2353@1|root,COG2353@2|Bacteria,1V1NX@1239|Firmicutes,24PTW@186801|Clostridia	186801|Clostridia	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
CMS3_k127_3782767_0	1379698.RBG1_1C00001G0178	1.092e-124	413.0	COG2265@1|root,COG2265@2|Bacteria,2NNWX@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
CMS3_k127_3782767_5	385682.AFSL01000105_gene72	2.37e-08	67.0	COG2244@1|root,COG2244@2|Bacteria,4NU9R@976|Bacteroidetes,2G2GA@200643|Bacteroidia,3XJ53@558415|Marinilabiliaceae	976|Bacteroidetes	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
CMS3_k127_3782767_1	671143.DAMO_3020	7.738e-51	193.0	COG1051@1|root,COG2138@1|root,COG1051@2|Bacteria,COG2138@2|Bacteria,2NPZ5@2323|unclassified Bacteria	2|Bacteria	F	NUDIX domain	cbiX	-	1.1.1.169,3.1.3.25,3.6.1.55,4.99.1.3	ko:K00077,ko:K01092,ko:K03574,ko:K03795	ko00521,ko00562,ko00770,ko00860,ko01100,ko01110,ko01120,ko04070,map00521,map00562,map00770,map00860,map01100,map01110,map01120,map04070	M00119,M00131	R01185,R01186,R01187,R02472,R05807	RC00078,RC00726,RC01012	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	CbiX,NUDIX
CMS3_k127_3782767_2	370438.PTH_1946	3.469e-47	180.0	COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,24FRV@186801|Clostridia,261K2@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
CMS3_k127_3782767_4	204669.Acid345_2643	1.314e-10	67.0	COG0477@1|root,COG2814@2|Bacteria,3Y2VT@57723|Acidobacteria,2JIIT@204432|Acidobacteriia	204432|Acidobacteriia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_3792982_2	204669.Acid345_1106	0.0002154	53.0	COG0457@1|root,COG0457@2|Bacteria,3Y3JH@57723|Acidobacteria,2JI8K@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
CMS3_k127_3792982_3	1121933.AUHH01000023_gene959	0.0008715	51.0	COG1807@1|root,COG1807@2|Bacteria,2GNPY@201174|Actinobacteria	201174|Actinobacteria	M	capsule polysaccharide biosynthetic process	-	-	-	ko:K13687	-	-	-	-	ko00000,ko01000,ko01003	-	GT89	-	-
CMS3_k127_3792982_1	1121920.AUAU01000004_gene583	6.792e-06	59.0	COG2199@1|root,COG3292@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,3Y3YU@57723|Acidobacteria	57723|Acidobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Reg_prop,Y_Y_Y
CMS3_k127_3792982_0	158189.SpiBuddy_0713	1.281e-136	448.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N,XFP,XFP_N
CMS3_k127_3793517_1	530564.Psta_2696	1.132e-13	83.0	COG2304@1|root,COG2304@2|Bacteria,2IYCE@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
CMS3_k127_3793517_0	684949.ATTJ01000001_gene1853	1.177e-17	94.0	COG4085@1|root,COG4085@2|Bacteria	2|Bacteria	S	PFAM nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,LTD
CMS3_k127_3794270_5	479434.Sthe_3345	3.694e-12	73.0	COG1595@1|root,COG1595@2|Bacteria,2G6UE@200795|Chloroflexi,27YF3@189775|Thermomicrobia	189775|Thermomicrobia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3794270_6	1172188.KB911820_gene3085	1.013e-10	69.0	28RB9@1|root,2ZDQU@2|Bacteria,2GZQK@201174|Actinobacteria,4FIZG@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3794270_3	1121920.AUAU01000027_gene1499	5.445e-72	260.0	COG1335@1|root,COG1335@2|Bacteria,3Y5W2@57723|Acidobacteria	57723|Acidobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS3_k127_3794270_0	1192034.CAP_2428	1.422e-106	378.0	COG0488@1|root,COG0488@2|Bacteria,1R0NJ@1224|Proteobacteria,43CZ8@68525|delta/epsilon subdivisions,2X87F@28221|Deltaproteobacteria,2Z03E@29|Myxococcales	28221|Deltaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3794270_2	1192034.CAP_2429	4.25e-82	280.0	COG0668@1|root,COG0668@2|Bacteria,1QATN@1224|Proteobacteria,42RFA@68525|delta/epsilon subdivisions,2WNFU@28221|Deltaproteobacteria,2YWRD@29|Myxococcales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
CMS3_k127_3794270_1	278957.ABEA03000106_gene1831	3.656e-86	300.0	COG1055@1|root,COG1055@2|Bacteria,46Y27@74201|Verrucomicrobia,3K8TR@414999|Opitutae	414999|Opitutae	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
CMS3_k127_3794270_4	1356852.N008_08475	1.917e-56	216.0	COG0204@1|root,COG0204@2|Bacteria,4NK8Z@976|Bacteroidetes,47NT5@768503|Cytophagia	976|Bacteroidetes	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
CMS3_k127_3817769_2	1089550.ATTH01000001_gene2122	3.481e-96	323.0	COG1192@1|root,COG1192@2|Bacteria,4NFEX@976|Bacteroidetes,1FJ0J@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	D	Cellulose biosynthesis protein BcsQ	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS3_k127_3817769_3	555079.Toce_2275	4.017e-72	253.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,42FPF@68295|Thermoanaerobacterales	186801|Clostridia	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
CMS3_k127_3817769_5	1131269.AQVV01000061_gene2124	3.092e-33	139.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
CMS3_k127_3817769_6	273068.TTE0840	9.676e-21	99.0	COG1664@1|root,COG1664@2|Bacteria,1VEVU@1239|Firmicutes,24QT5@186801|Clostridia,42GQS@68295|Thermoanaerobacterales	186801|Clostridia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
CMS3_k127_3817769_0	1379698.RBG1_1C00001G0201	4.454e-131	429.0	COG0714@1|root,COG0714@2|Bacteria,2NNV8@2323|unclassified Bacteria	2|Bacteria	O	ATPase family associated with various cellular activities (AAA)	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_3817769_1	1379698.RBG1_1C00001G0202	1.149e-109	362.0	COG1721@1|root,COG1721@2|Bacteria,2NP6B@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_3817769_4	1123242.JH636437_gene6154	6.762e-39	166.0	COG5426@1|root,COG5426@2|Bacteria,2IY0Y@203682|Planctomycetes	203682|Planctomycetes	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
CMS3_k127_3827173_1	383372.Rcas_0812	3.697e-169	563.0	COG1449@1|root,COG1449@2|Bacteria,2G5XB@200795|Chloroflexi,3768X@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
CMS3_k127_3827173_0	1089553.Tph_c09150	1.676e-218	690.0	COG1543@1|root,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,248UF@186801|Clostridia,42FVE@68295|Thermoanaerobacterales	186801|Clostridia	G	Domain of unknown function (DUF1957)	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
CMS3_k127_3827173_3	485916.Dtox_0802	3.876e-30	132.0	COG3330@1|root,COG3330@2|Bacteria,1V2ZT@1239|Firmicutes,24H5R@186801|Clostridia,261HH@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4912)	-	-	-	ko:K09942	-	-	-	-	ko00000	-	-	-	DUF4912
CMS3_k127_3827173_2	521674.Plim_0560	8.345e-34	135.0	COG1832@1|root,COG1832@2|Bacteria,2J066@203682|Planctomycetes	203682|Planctomycetes	S	CoA-binding protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
CMS3_k127_3827457_2	314230.DSM3645_26649	1.88e-34	147.0	COG0737@1|root,COG0737@2|Bacteria,2IXWK@203682|Planctomycetes	203682|Planctomycetes	C	5'-nucleotidase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
CMS3_k127_3827457_3	635013.TherJR_1371	2.203e-32	137.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,2619M@186807|Peptococcaceae	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
CMS3_k127_3827457_4	243090.RB252	5.1e-21	102.0	COG0727@1|root,COG0727@2|Bacteria,2IZU5@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
CMS3_k127_3827457_5	518766.Rmar_1812	8.045e-15	84.0	COG1254@1|root,COG1254@2|Bacteria,4NVB4@976|Bacteroidetes,1FJMR@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Acylphosphatase	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
CMS3_k127_3827457_1	479434.Sthe_2024	3.743e-138	456.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,2G698@200795|Chloroflexi,27YAJ@189775|Thermomicrobia	189775|Thermomicrobia	E	Cysteine synthase	-	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738,ko:K12339	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03132,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_3827457_0	945713.IALB_2140	7.406e-147	477.0	COG0626@1|root,COG0626@2|Bacteria	2|Bacteria	E	cystathionine gamma-synthase activity	metC	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004121,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8	ko:K01739,ko:K01758,ko:K01760,ko:K01761	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00654,R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
CMS3_k127_3840998_5	497964.CfE428DRAFT_1901	4.045e-26	108.0	COG0236@1|root,COG0236@2|Bacteria,46T18@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CMS3_k127_3840998_0	635013.TherJR_2071	1.278e-154	499.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,2602N@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS3_k127_3840998_2	1379698.RBG1_1C00001G1823	9.479e-56	204.0	COG0571@1|root,COG0571@2|Bacteria,2NPCJ@2323|unclassified Bacteria	2|Bacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
CMS3_k127_3840998_3	1499967.BAYZ01000195_gene3095	2.994e-44	182.0	COG0457@1|root,COG0457@2|Bacteria,2NPEN@2323|unclassified Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
CMS3_k127_3840998_4	518766.Rmar_2628	3.477e-39	160.0	COG1595@1|root,COG1595@2|Bacteria,4NQE0@976|Bacteroidetes,1FISP@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_3840998_7	999419.HMPREF1077_00715	1.133e-07	63.0	COG0322@1|root,COG0322@2|Bacteria,4NGEV@976|Bacteroidetes,2FNVF@200643|Bacteroidia,22XZM@171551|Porphyromonadaceae	976|Bacteroidetes	L	Domain of unknown function (DUF4837)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4837
CMS3_k127_3840998_1	1385515.N791_03495	1.877e-63	242.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1X42C@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
CMS3_k127_3840998_6	269799.Gmet_0979	2.61e-08	67.0	COG0457@1|root,COG0457@2|Bacteria,1NEMW@1224|Proteobacteria,42WBX@68525|delta/epsilon subdivisions,2WRAD@28221|Deltaproteobacteria,43VAR@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_8
CMS3_k127_385917_1	1444711.CCJF01000005_gene1446	1.222e-140	461.0	COG3280@1|root,COG3280@2|Bacteria,2JFUZ@204428|Chlamydiae	204428|Chlamydiae	G	Alpha amylase, catalytic domain	-	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
CMS3_k127_385917_0	1382356.JQMP01000004_gene486	9.091e-314	971.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia	189775|Thermomicrobia	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
CMS3_k127_3867729_2	1210884.HG799474_gene15186	3.657e-37	147.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
CMS3_k127_3867729_0	1515746.HR45_10035	1.277e-236	751.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria,2Q9TR@267890|Shewanellaceae	1236|Gammaproteobacteria	O	PFAM peptidase M13, neprilysin	pepO	-	3.4.24.71	ko:K01415,ko:K07386	-	-	-	-	ko00000,ko01000,ko01002,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
CMS3_k127_3867729_3	880073.Calab_2082	1.985e-12	81.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF4114,DUF4157
CMS3_k127_3867729_1	946362.XP_004997743.1	1.635e-179	591.0	COG2132@1|root,2QR4X@2759|Eukaryota,38BK4@33154|Opisthokonta	33154|Opisthokonta	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
CMS3_k127_3905066_0	314230.DSM3645_10052	8.83e-147	484.0	COG0457@1|root,COG0457@2|Bacteria,2IXTF@203682|Planctomycetes	203682|Planctomycetes	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_3905066_4	452637.Oter_0807	7.476e-32	129.0	COG2010@1|root,COG2010@2|Bacteria,46TBB@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
CMS3_k127_3905066_1	1267535.KB906767_gene1129	6.284e-124	436.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_3905066_3	1265502.KB905959_gene247	1.638e-44	170.0	290UJ@1|root,2ZNGJ@2|Bacteria,1RBSP@1224|Proteobacteria,2VZ0V@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3905066_2	1151122.AQYD01000007_gene53	1.321e-44	171.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,4FKAJ@85023|Microbacteriaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
CMS3_k127_390826_0	880073.Calab_2517	1.385e-161	522.0	COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48,4.4.1.11,4.4.1.8	ko:K01739,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
CMS3_k127_390826_2	1121405.dsmv_0026	3.239e-64	233.0	COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,42RKY@68525|delta/epsilon subdivisions,2WNSM@28221|Deltaproteobacteria,2MJZR@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS3_k127_390826_3	234267.Acid_1599	2.57e-07	59.0	COG0793@1|root,COG0793@2|Bacteria,3Y6R0@57723|Acidobacteria	57723|Acidobacteria	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
CMS3_k127_390826_1	682795.AciX8_1998	1.656e-73	261.0	COG0793@1|root,COG0793@2|Bacteria,3Y6R0@57723|Acidobacteria	57723|Acidobacteria	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
CMS3_k127_3914809_1	278957.ABEA03000013_gene2660	5.839e-08	63.0	2DMI2@1|root,32RP8@2|Bacteria,46Y4T@74201|Verrucomicrobia,3K8XN@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3914809_0	1123489.AUAN01000008_gene142	1.028e-22	112.0	COG4775@1|root,COG4775@2|Bacteria,1UMDS@1239|Firmicutes,4H27F@909932|Negativicutes	909932|Negativicutes	M	Outer membrane protein, OMP85 family	yaeT	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
CMS3_k127_3955422_0	1267535.KB906767_gene2623	2.414e-62	229.0	COG0616@1|root,COG0616@2|Bacteria,3Y3M1@57723|Acidobacteria	57723|Acidobacteria	OU	PFAM peptidase S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
CMS3_k127_3955422_1	1125863.JAFN01000001_gene739	5.543e-46	184.0	COG1503@1|root,COG1503@2|Bacteria,1NHEV@1224|Proteobacteria,42XGN@68525|delta/epsilon subdivisions,2WTEW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	translation release factor activity	-	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	-
CMS3_k127_3956412_3	572478.Vdis_0681	2.606e-29	138.0	COG0069@1|root,arCOG00619@2157|Archaea,2XQF1@28889|Crenarchaeota	28889|Crenarchaeota	E	Glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	GXGXG,Glu_syn_central,Glu_synthase
CMS3_k127_3956412_5	406327.Mevan_1110	1.927e-05	58.0	arCOG01611@1|root,arCOG01611@2157|Archaea,2Y0ZE@28890|Euryarchaeota,23R9V@183939|Methanococci	183939|Methanococci	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
CMS3_k127_3956412_4	1094980.Mpsy_1043	3.399e-11	77.0	COG0277@1|root,arCOG00340@2157|Archaea,2XVP5@28890|Euryarchaeota,2NABB@224756|Methanomicrobia	224756|Methanomicrobia	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD_binding_4,Fer4_17
CMS3_k127_3956412_1	1449126.JQKL01000002_gene1625	8.779e-66	251.0	COG0421@1|root,COG0421@2|Bacteria,1VRGK@1239|Firmicutes,24C37@186801|Clostridia	186801|Clostridia	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
CMS3_k127_3956412_2	880073.Calab_0150	8.858e-47	181.0	COG1597@1|root,COG1597@2|Bacteria,2NQYH@2323|unclassified Bacteria	2|Bacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
CMS3_k127_3956412_0	457415.HMPREF1006_00027	1.248e-70	248.0	COG0542@1|root,COG0542@2|Bacteria,3TA3A@508458|Synergistetes	508458|Synergistetes	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
CMS3_k127_3958866_0	234267.Acid_0353	2.946e-140	462.0	COG0022@1|root,COG0022@2|Bacteria,3Y48G@57723|Acidobacteria	57723|Acidobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS3_k127_3958866_4	1128421.JAGA01000002_gene1753	1.19e-10	72.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,2NPIU@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
CMS3_k127_3958866_6	768670.Calni_0951	6.403e-09	64.0	COG0265@1|root,COG0265@2|Bacteria,2GERQ@200930|Deferribacteres	2|Bacteria	M	PFAM peptidase S1 and S6 chymotrypsin Hap	degQ	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_3958866_1	309807.SRU_2467	1.077e-88	310.0	COG4409@1|root,COG4409@2|Bacteria,4NI5M@976|Bacteroidetes	976|Bacteroidetes	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3958866_3	1089544.KB912942_gene587	2.349e-50	189.0	COG1647@1|root,COG1647@2|Bacteria,2GM1Y@201174|Actinobacteria,4DZX1@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM alpha beta hydrolase fold	yvaK	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
CMS3_k127_3958866_2	1499967.BAYZ01000196_gene3072	1.799e-64	233.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	AAA_31,Patatin,cNMP_binding
CMS3_k127_3958866_7	1267600.JFGT01000002_gene324	2.924e-07	53.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,3VXJZ@53335|Pantoea	1236|Gammaproteobacteria	I	Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities	fadJ	GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c26730,iETEC_1333.ETEC_2476,iEcE24377_1341.EcE24377A_2637,ic_1306.c2886	3HCDH,3HCDH_N,ECH_1
CMS3_k127_3969981_1	1122134.KB893650_gene305	1.744e-40	161.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
CMS3_k127_3969981_0	1321778.HMPREF1982_00036	8.585e-198	638.0	COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,26881@186813|unclassified Clostridiales	186801|Clostridia	EJ	Psort location Cytoplasmic, score	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
CMS3_k127_3969981_2	1047013.AQSP01000142_gene242	3.043e-37	156.0	COG2511@1|root,COG2511@2|Bacteria	2|Bacteria	J	GatB/GatE catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	GatB_N
CMS3_k127_3993395_3	172088.AUGA01000021_gene5214	0.0002703	51.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TVAX@28211|Alphaproteobacteria,3JXIS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_3993395_2	1121918.ARWE01000001_gene3348	1.002e-06	60.0	COG1102@1|root,COG1102@2|Bacteria,1R4GX@1224|Proteobacteria,42QKV@68525|delta/epsilon subdivisions,2WJS2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
CMS3_k127_3993395_1	382464.ABSI01000020_gene227	1.866e-48	192.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_3993395_0	264462.Bd0364	5.632e-134	439.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2MSTI@213481|Bdellovibrionales,2WJDZ@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
CMS3_k127_4051390_1	1499967.BAYZ01000026_gene1590	0.0001116	55.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_4051390_0	120017.I2FXI9	6.901e-06	59.0	KOG0547@1|root,KOG0547@2759|Eukaryota,38BB8@33154|Opisthokonta,3NUNW@4751|Fungi,3UZ4M@5204|Basidiomycota,3N0MB@452284|Ustilaginomycotina	4751|Fungi	U	Tetratricopeptide repeat	TOM70	GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005742,GO:0006605,GO:0006626,GO:0006810,GO:0006839,GO:0006886,GO:0006996,GO:0007005,GO:0007006,GO:0007007,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0017038,GO:0019867,GO:0030150,GO:0030943,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031306,GO:0031307,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0032592,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044743,GO:0045039,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070585,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0072594,GO:0072655,GO:0072657,GO:0090150,GO:0090151,GO:0098573,GO:0098588,GO:0098796,GO:0098798,GO:0098799,GO:0098805,GO:1990542	-	ko:K17768	-	-	-	-	ko00000,ko02000,ko03029	3.A.8.1	-	-	TPR_1,TPR_16,TPR_17,TPR_2,TPR_8
CMS3_k127_4093771_1	1267534.KB906757_gene1075	2.603e-96	332.0	COG0457@1|root,COG1225@1|root,COG0457@2|Bacteria,COG1225@2|Bacteria,3Y6YV@57723|Acidobacteria,2JKEW@204432|Acidobacteriia	204432|Acidobacteriia	O	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,TPR_11,TPR_2,TPR_8,UnbV_ASPIC,VCBS
CMS3_k127_4093771_2	1267534.KB906757_gene1075	2.175e-57	221.0	COG0457@1|root,COG1225@1|root,COG0457@2|Bacteria,COG1225@2|Bacteria,3Y6YV@57723|Acidobacteria,2JKEW@204432|Acidobacteriia	204432|Acidobacteriia	O	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,TPR_11,TPR_2,TPR_8,UnbV_ASPIC,VCBS
CMS3_k127_4093771_0	1379698.RBG1_1C00001G0900	6.955e-140	465.0	COG1529@1|root,COG1529@2|Bacteria,2NNTR@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.5,1.2.5.3	ko:K03520,ko:K20447,ko:K20448	ko00760,ko01120,map00760,map01120	-	R01720,R11168	RC00589,RC02800	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS3_k127_411336_1	1506583.JQJY01000008_gene3897	1.289e-17	89.0	COG1917@1|root,COG1917@2|Bacteria,4NQ5U@976|Bacteroidetes,1I3YX@117743|Flavobacteriia,2NX02@237|Flavobacterium	976|Bacteroidetes	S	Domain of unknown function (DUF4437)	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
CMS3_k127_411336_0	234267.Acid_7660	1.344e-204	645.0	COG0167@1|root,COG1149@1|root,COG0167@2|Bacteria,COG1149@2|Bacteria,3Y3D8@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM Dihydroorotate dehydrogenase	-	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_21
CMS3_k127_4142966_0	1054860.KB913030_gene6307	3.213e-117	396.0	COG1793@1|root,COG1793@2|Bacteria,2GJ2P@201174|Actinobacteria	201174|Actinobacteria	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
CMS3_k127_4149660_1	945713.IALB_2607	2.998e-05	56.0	COG4783@1|root,COG4783@2|Bacteria	2|Bacteria	L	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6,TPR_8
CMS3_k127_4149660_0	1408303.JNJJ01000055_gene1873	1.132e-08	58.0	COG4644@1|root,COG4644@2|Bacteria,1TRGX@1239|Firmicutes,4HAJF@91061|Bacilli,1ZB7A@1386|Bacillus	91061|Bacilli	L	Transposase and inactivated derivatives, TnpA family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
CMS3_k127_4156141_4	1122978.AUFP01000005_gene1449	0.0006732	51.0	COG2819@1|root,COG2819@2|Bacteria,4NGJB@976|Bacteroidetes,2FR8R@200643|Bacteroidia	976|Bacteroidetes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS3_k127_4156141_3	929556.Solca_4057	4.478e-28	128.0	COG0793@1|root,COG0793@2|Bacteria,4NEF4@976|Bacteroidetes,1IQVH@117747|Sphingobacteriia	976|Bacteroidetes	M	PDZ DHR GLGF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,PDZ,PDZ_2
CMS3_k127_4156141_1	391625.PPSIR1_02668	1.262e-103	349.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PYA@68525|delta/epsilon subdivisions,2WKM5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM aminotransferase class V	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
CMS3_k127_4156141_0	886293.Sinac_2294	2.458e-297	940.0	COG1032@1|root,COG1032@2|Bacteria,2IY6B@203682|Planctomycetes	203682|Planctomycetes	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
CMS3_k127_4156141_2	234267.Acid_6173	1.192e-29	121.0	COG1741@1|root,COG1741@2|Bacteria,3Y367@57723|Acidobacteria	57723|Acidobacteria	S	Pirin C-terminal cupin domain	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
CMS3_k127_4161059_0	330214.NIDE3501	7.551e-98	341.0	COG4907@1|root,COG4907@2|Bacteria	2|Bacteria	P	membrane protein (DUF2207)	yciQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2207
CMS3_k127_4161059_1	1042326.AZNV01000041_gene251	8.407e-43	160.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2U6EM@28211|Alphaproteobacteria,4B7ZG@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
CMS3_k127_416576_0	234267.Acid_0400	3.738e-84	291.0	COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	-
CMS3_k127_416576_1	234267.Acid_0399	3.397e-74	253.0	COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria	2|Bacteria	C	Polysulphide reductase, NrfD	qrcD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
CMS3_k127_4206773_6	1469245.JFBG01000013_gene1935	1.067e-14	87.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,1RNFN@1236|Gammaproteobacteria,1WZY2@135613|Chromatiales	135613|Chromatiales	C	Aldehyde dehydrogenase family	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_4206773_2	323850.Shew_3533	3.432e-54	202.0	COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,1RYXR@1236|Gammaproteobacteria,2QB1M@267890|Shewanellaceae	1236|Gammaproteobacteria	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
CMS3_k127_4206773_1	1121930.AQXG01000001_gene1127	2.675e-119	389.0	COG0388@1|root,COG0388@2|Bacteria,4NEME@976|Bacteroidetes,1IPIY@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	pabB	-	3.5.1.53,3.5.1.6	ko:K01431,ko:K12251	ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100	M00046	R00905,R01152,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
CMS3_k127_4206773_0	926550.CLDAP_28000	4.082e-191	608.0	COG0626@1|root,COG0626@2|Bacteria,2G7Q6@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Cys Met metabolism pyridoxal-phosphate-dependent	-	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
CMS3_k127_4206773_5	1330700.JQNC01000003_gene31	6.048e-22	103.0	COG2110@1|root,COG2110@2|Bacteria,1WJ1P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	phosphatase homologous to the C-terminal domain of histone macroH2A1	-	-	-	-	-	-	-	-	-	-	-	-	Macro
CMS3_k127_4206773_4	1123371.ATXH01000001_gene1188	4.123e-23	100.0	2CHNQ@1|root,2Z7KM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4210516_0	1254432.SCE1572_13050	2.57e-162	525.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,43BBS@68525|delta/epsilon subdivisions,2X6QY@28221|Deltaproteobacteria,2YU79@29|Myxococcales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
CMS3_k127_4210516_1	1379698.RBG1_1C00001G0457	2.107e-63	225.0	COG0705@1|root,COG0705@2|Bacteria,2NPGI@2323|unclassified Bacteria	2|Bacteria	S	(Rhomboid) family	GlpG	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid
CMS3_k127_4210516_2	1237149.C900_05113	2.949e-38	148.0	COG0405@1|root,COG0405@2|Bacteria,4NF2H@976|Bacteroidetes,47K06@768503|Cytophagia	976|Bacteroidetes	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CMS3_k127_421485_2	1121468.AUBR01000019_gene2618	3.258e-75	265.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,42F2M@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
CMS3_k127_421485_0	760568.Desku_0346	4.412e-101	344.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,26184@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
CMS3_k127_421485_1	357808.RoseRS_0842	1.761e-95	342.0	COG4992@1|root,COG4992@2|Bacteria,2G5TW@200795|Chloroflexi,3758Z@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM acetylornithine and succinylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_421485_4	880073.Calab_2281	4.755e-13	76.0	COG1438@1|root,COG1438@2|Bacteria,2NRVI@2323|unclassified Bacteria	2|Bacteria	K	Arginine repressor, DNA binding domain	argR	GO:0000820,GO:0000821,GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006259,GO:0006310,GO:0006355,GO:0006520,GO:0006521,GO:0006525,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016043,GO:0016597,GO:0019219,GO:0019222,GO:0019752,GO:0022607,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031329,GO:0031333,GO:0031334,GO:0031406,GO:0032991,GO:0032993,GO:0033238,GO:0033241,GO:0034214,GO:0034618,GO:0034641,GO:0036094,GO:0042150,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043254,GO:0043436,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044424,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051259,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140110,GO:1900079,GO:1900081,GO:1901360,GO:1901363,GO:1901564,GO:1901605,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2000144,GO:2000282,GO:2001141	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
CMS3_k127_4251196_9	861299.J421_3279	7.414e-05	54.0	COG0045@1|root,COG0045@2|Bacteria,1ZSZ4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
CMS3_k127_4251196_1	264462.Bd2106	4.166e-56	219.0	COG3016@1|root,COG3016@2|Bacteria,1N1D9@1224|Proteobacteria,42TQT@68525|delta/epsilon subdivisions,2MT10@213481|Bdellovibrionales,2WQ8G@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	Haem-binding uptake, Tiki superfamily, ChaN	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg
CMS3_k127_4251196_7	667014.Thein_1588	4.698e-10	64.0	COG1826@1|root,COG1826@2|Bacteria,2GIP7@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	U	mttA/Hcf106 family	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
CMS3_k127_4251196_2	357808.RoseRS_0543	4.124e-40	164.0	COG0315@1|root,COG0315@2|Bacteria,2G6PC@200795|Chloroflexi,375NJ@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
CMS3_k127_4251196_5	1340493.JNIF01000003_gene1727	5.727e-12	74.0	COG0746@1|root,COG0746@2|Bacteria,3Y5GH@57723|Acidobacteria	57723|Acidobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS3_k127_4251196_8	285535.JOEY01000019_gene2410	7.434e-07	62.0	COG3170@1|root,COG3170@2|Bacteria,2I40K@201174|Actinobacteria	201174|Actinobacteria	NU	Glycosyltransferase family 87	-	-	-	ko:K13671	-	-	-	-	ko00000,ko01000,ko01003	-	GT87	-	GT87
CMS3_k127_4251196_6	880073.Calab_2081	4.594e-11	77.0	COG3291@1|root,COG5276@1|root,COG3291@2|Bacteria,COG5276@2|Bacteria,2NQ2P@2323|unclassified Bacteria	2|Bacteria	P	LVIVD repeat	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	LVIVD
CMS3_k127_4251196_0	1379698.RBG1_1C00001G1092	1.241e-81	303.0	COG2866@1|root,COG4412@1|root,COG2866@2|Bacteria,COG4412@2|Bacteria,2NPI7@2323|unclassified Bacteria	2|Bacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.4.17.18,3.4.17.22	ko:K05996,ko:K07752	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	F5_F8_type_C,Peptidase_M14,Peptidase_M6,Ricin_B_lectin,fn3
CMS3_k127_4251196_3	1379698.RBG1_1C00001G0502	3.06e-28	124.0	COG1729@1|root,COG1729@2|Bacteria,2NQ0B@2323|unclassified Bacteria	2|Bacteria	S	Outer membrane lipoprotein	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
CMS3_k127_4251196_4	319225.Plut_0616	7.192e-22	95.0	COG2885@1|root,COG2885@2|Bacteria,1FEC5@1090|Chlorobi	1090|Chlorobi	M	PFAM OmpA MotB domain protein	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
CMS3_k127_4254708_1	511051.CSE_02040	4.451e-20	101.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
CMS3_k127_4254708_2	414684.RC1_0803	3.723e-07	62.0	COG0810@1|root,COG0810@2|Bacteria,1PEDH@1224|Proteobacteria,2UEEK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
CMS3_k127_4254708_0	1121423.JONT01000011_gene247	2.797e-92	317.0	COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,2498U@186801|Clostridia,2608U@186807|Peptococcaceae	186801|Clostridia	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
CMS3_k127_4277180_2	408672.NBCG_02241	8.94e-28	120.0	COG1524@1|root,COG1524@2|Bacteria,2HY6Q@201174|Actinobacteria,4DT1Q@85009|Propionibacteriales	201174|Actinobacteria	S	Metalloenzyme superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
CMS3_k127_4277180_3	1268622.AVS7_03365	9.848e-11	72.0	COG3428@1|root,COG3428@2|Bacteria,1NBZS@1224|Proteobacteria,2VYKU@28216|Betaproteobacteria,4AIQ7@80864|Comamonadaceae	28216|Betaproteobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_4
CMS3_k127_4277180_4	637910.ROD_31411	1.356e-07	58.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,3WYJD@544|Citrobacter	1236|Gammaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	ygaV	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0044212,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	HTH_5
CMS3_k127_4277180_0	404589.Anae109_4110	3.193e-100	339.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,43BMM@68525|delta/epsilon subdivisions,2X64M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Molydopterin dinucleotide binding domain	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdopterin,Molydop_binding
CMS3_k127_4277180_5	234267.Acid_2432	3.568e-07	63.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
CMS3_k127_4277180_1	760192.Halhy_5410	1.003e-69	245.0	COG0457@1|root,COG0526@1|root,COG0457@2|Bacteria,COG0526@2|Bacteria,4NQI3@976|Bacteroidetes,1ITTM@117747|Sphingobacteriia	976|Bacteroidetes	CO	thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin,Thioredoxin_9
CMS3_k127_4284039_0	867845.KI911784_gene2185	4.713e-101	338.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,2G6C1@200795|Chloroflexi,376FK@32061|Chloroflexia	32061|Chloroflexia	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
CMS3_k127_4284039_2	525904.Tter_1596	3.922e-90	301.0	COG3880@1|root,COG3880@2|Bacteria,2NPCX@2323|unclassified Bacteria	2|Bacteria	S	Cytochrome c7 and related cytochrome c	mcsA	GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170	2.7.14.1	ko:K19405,ko:K19411	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	Cytochrom_CIII,Cytochrome_C7,GSu_C4xC__C2xCH,UVR
CMS3_k127_4284039_1	675635.Psed_3380	1.189e-91	313.0	COG4301@1|root,COG4301@2|Bacteria,2GJAX@201174|Actinobacteria,4DYPU@85010|Pseudonocardiales	201174|Actinobacteria	S	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine	egtD	-	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
CMS3_k127_4284039_3	266117.Rxyl_0297	2.181e-73	256.0	COG1914@1|root,COG1914@2|Bacteria,2IBKH@201174|Actinobacteria	201174|Actinobacteria	P	Mn2 and Fe2 transporters of the NRAMP family	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
CMS3_k127_428548_0	1232410.KI421428_gene1067	6.699e-144	467.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,42P1M@68525|delta/epsilon subdivisions,2WKJ2@28221|Deltaproteobacteria,43S3B@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
CMS3_k127_428548_1	292459.STH658	5.367e-103	347.0	COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,248FK@186801|Clostridia	186801|Clostridia	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS3_k127_428548_2	338963.Pcar_3021	5.088e-60	214.0	COG4894@1|root,COG4894@2|Bacteria,1RHRT@1224|Proteobacteria,42TF0@68525|delta/epsilon subdivisions,2WPE4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Scramblase	-	-	-	-	-	-	-	-	-	-	-	-	Scramblase
CMS3_k127_428548_4	1316936.K678_08324	1.793e-17	89.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2U5B9@28211|Alphaproteobacteria,2JRRT@204441|Rhodospirillales	204441|Rhodospirillales	K	transcriptional regulator	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
CMS3_k127_428548_3	1125863.JAFN01000001_gene2796	1.035e-25	117.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42PJ7@68525|delta/epsilon subdivisions,2WMEM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
CMS3_k127_4318239_0	886293.Sinac_7091	0.0	1158.0	COG0458@1|root,COG0458@2|Bacteria,2IXR6@203682|Planctomycetes	203682|Planctomycetes	F	Carbamoylphosphate synthase large subunit	carB	GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
CMS3_k127_4318239_1	1267533.KB906739_gene2546	6.871e-115	392.0	COG0505@1|root,COG0505@2|Bacteria,3Y31Y@57723|Acidobacteria,2JIB8@204432|Acidobacteriia	204432|Acidobacteriia	F	TIGRFAM Carbamoyl-phosphate synthase, small subunit	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
CMS3_k127_4328414_2	1232437.KL662036_gene2701	1.878e-68	247.0	COG2220@1|root,COG2220@2|Bacteria,1QB9E@1224|Proteobacteria,42N7W@68525|delta/epsilon subdivisions,2WMED@28221|Deltaproteobacteria,2MQ1N@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CMS3_k127_4328414_1	1123228.AUIH01000007_gene2581	4.46e-109	364.0	COG0667@1|root,COG0667@2|Bacteria,1PDY4@1224|Proteobacteria,1RQYV@1236|Gammaproteobacteria,1XIDK@135619|Oceanospirillales	135619|Oceanospirillales	C	Aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS3_k127_4328414_3	1232410.KI421428_gene1021	2.055e-30	125.0	COG0011@1|root,COG0011@2|Bacteria,1N2GU@1224|Proteobacteria,42UPF@68525|delta/epsilon subdivisions,2WR94@28221|Deltaproteobacteria,43W2X@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
CMS3_k127_4328414_0	1185876.BN8_05813	3.202e-142	457.0	COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,47ME9@768503|Cytophagia	976|Bacteroidetes	M	membrane protein involved in D-alanine export	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
CMS3_k127_4353777_1	1121904.ARBP01000012_gene1371	6.931e-99	341.0	COG3264@1|root,COG3264@2|Bacteria,4NEAM@976|Bacteroidetes,47KYP@768503|Cytophagia	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
CMS3_k127_4353777_0	309801.trd_1930	3.607e-231	727.0	COG0366@1|root,COG0366@2|Bacteria,2G89J@200795|Chloroflexi,27XYW@189775|Thermomicrobia	189775|Thermomicrobia	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
CMS3_k127_4380111_0	1125863.JAFN01000001_gene3585	1.771e-145	486.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	PFAM cell divisionFtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
CMS3_k127_4385302_5	1131269.AQVV01000008_gene964	1.664e-34	138.0	COG0803@1|root,COG0803@2|Bacteria	2|Bacteria	P	Belongs to the bacterial solute-binding protein 9 family	znuA	-	-	ko:K02077,ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
CMS3_k127_4385302_6	387092.NIS_0025	6.267e-19	100.0	COG3170@1|root,COG3170@2|Bacteria,1QX7F@1224|Proteobacteria,42NQR@68525|delta/epsilon subdivisions,2YTDF@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4385302_4	1121920.AUAU01000014_gene2815	2.2e-35	140.0	COG0735@1|root,COG0735@2|Bacteria,3Y5IN@57723|Acidobacteria	57723|Acidobacteria	P	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS3_k127_4385302_0	404589.Anae109_2250	8.179e-212	684.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42PVA@68525|delta/epsilon subdivisions,2WJ10@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB-1	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
CMS3_k127_4385302_2	290397.Adeh_1566	6.025e-53	194.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,1N3ZM@1224|Proteobacteria,42TUU@68525|delta/epsilon subdivisions,2WQ8Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KP	PFAM iron dependent repressor	ideR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,FeoA
CMS3_k127_4385302_1	1288826.MSNKSG1_16491	1.017e-68	239.0	COG2129@1|root,COG2129@2|Bacteria,1RFU9@1224|Proteobacteria,1S4S2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	phosphoesterases, related to the Icc protein	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
CMS3_k127_4385302_8	1071085.KK033115_gene1816	2.398e-10	70.0	28HQU@1|root,2N5R0@2157|Archaea,2XW58@28890|Euryarchaeota,23V1K@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4385302_3	304371.MCP_0732	1.007e-45	169.0	COG0432@1|root,arCOG04214@2157|Archaea,2XYW0@28890|Euryarchaeota,2N9WB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CMS3_k127_4385302_7	1288079.AUKN01000003_gene3817	2.364e-12	79.0	COG0697@1|root,COG0697@2|Bacteria,2H1HG@201174|Actinobacteria	201174|Actinobacteria	EG	Permeases of the drug metabolite transporter DMT superfamily	eamA	-	-	ko:K15268	-	-	-	-	ko00000,ko02000	2.A.7.3.2	-	-	EamA
CMS3_k127_4390761_0	1502850.FG91_02597	3.161e-89	304.0	COG1335@1|root,COG1335@2|Bacteria,1N48X@1224|Proteobacteria,2U17G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG1335 Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS3_k127_4390761_1	62928.azo1484	7.285e-59	211.0	COG2132@1|root,COG2374@1|root,COG2132@2|Bacteria,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,2VK7U@28216|Betaproteobacteria,2KY0R@206389|Rhodocyclales	206389|Rhodocyclales	Q	Endonuclease/Exonuclease/phosphatase family	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Exo_endo_phos
CMS3_k127_4426821_1	330214.NIDE2037	3.511e-108	363.0	COG1916@1|root,COG1916@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4426821_0	530564.Psta_2121	1.118e-146	473.0	COG0714@1|root,COG0714@2|Bacteria,2IY43@203682|Planctomycetes	203682|Planctomycetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
CMS3_k127_4426821_2	1123242.JH636434_gene3634	2.024e-65	229.0	COG0294@1|root,COG0294@2|Bacteria,2IYYU@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CMS3_k127_4438283_4	1278073.MYSTI_07139	4.084e-06	56.0	COG3716@1|root,COG3716@2|Bacteria,1MWTZ@1224|Proteobacteria,42SXR@68525|delta/epsilon subdivisions,2WPQN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	system, mannose fructose sorbose family, IID component	-	-	-	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1	-	-	EIID-AGA
CMS3_k127_4438283_3	500635.MITSMUL_04292	2.866e-11	74.0	COG1925@1|root,COG1925@2|Bacteria,1VA0R@1239|Firmicutes,4H5F2@909932|Negativicutes	909932|Negativicutes	G	Phosphocarrier protein hpr	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
CMS3_k127_4438283_0	555079.Toce_1427	4.208e-176	569.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,42FHW@68295|Thermoanaerobacterales	186801|Clostridia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsP	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
CMS3_k127_4438283_2	1121430.JMLG01000009_gene429	1.378e-59	221.0	COG2222@1|root,COG2222@2|Bacteria,1TRBS@1239|Firmicutes,24A9W@186801|Clostridia,25ZZA@186807|Peptococcaceae	186801|Clostridia	G	Sugar isomerase (SIS)	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
CMS3_k127_4438283_1	867903.ThesuDRAFT_02381	5.743e-66	230.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,3WCCV@538999|Clostridiales incertae sedis	186801|Clostridia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
CMS3_k127_4439551_3	1219084.AP014508_gene1160	2.338e-07	61.0	COG1404@1|root,COG1404@2|Bacteria,2GDZM@200918|Thermotogae	200918|Thermotogae	O	Subtilase family	-	-	3.4.21.62	ko:K01342	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
CMS3_k127_4439551_4	1085623.GNIT_3312	0.0003713	51.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,465UW@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PKD,Peptidase_S8
CMS3_k127_4439551_1	1279017.AQYJ01000024_gene1001	2.095e-84	307.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S41,TPR_8,Tricorn_C1
CMS3_k127_4439551_0	1278073.MYSTI_05278	2.154e-230	726.0	COG0520@1|root,COG0520@2|Bacteria,1N124@1224|Proteobacteria,42M1A@68525|delta/epsilon subdivisions	1224|Proteobacteria	E	Aminotransferase	csdA	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_4439551_2	596151.DesfrDRAFT_0647	1.006e-31	130.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,42QJC@68525|delta/epsilon subdivisions,2WPI2@28221|Deltaproteobacteria,2M9VY@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_10,TPR_16,TPR_19,TPR_4,TPR_8
CMS3_k127_4440284_1	420324.KI911943_gene5343	5.376e-70	246.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
CMS3_k127_4440284_0	314285.KT71_02867	2.27e-115	383.0	COG5505@1|root,COG5505@2|Bacteria,1RAF4@1224|Proteobacteria,1RW3T@1236|Gammaproteobacteria,1J85W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF819
CMS3_k127_4443205_2	1499967.BAYZ01000188_gene3892	1.028e-117	383.0	COG0031@1|root,COG0031@2|Bacteria,2NNZI@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47,6.2.1.30	ko:K01738,ko:K01912	ko00270,ko00360,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko05111,map00270,map00360,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map05111	M00021	R00897,R02539,R03601,R04859	RC00004,RC00014,RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_4443205_1	330214.NIDE3598	1.717e-143	461.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
CMS3_k127_4443205_0	485915.Dret_1750	3.109e-294	925.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N,XFP,XFP_N
CMS3_k127_4443205_3	338963.Pcar_2716	5.698e-114	376.0	COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria,42NWP@68525|delta/epsilon subdivisions,2WJUA@28221|Deltaproteobacteria,43TPM@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	FAD binding domain of DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
CMS3_k127_4460022_2	1198452.Jab_2c34270	9.03e-100	333.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2VMB3@28216|Betaproteobacteria,4779T@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_4460022_4	1499967.BAYZ01000159_gene523	5.057e-05	48.0	COG3199@1|root,COG3199@2|Bacteria	2|Bacteria	S	ATP-NAD kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
CMS3_k127_4460022_0	446470.Snas_2731	1.17e-219	692.0	COG1003@1|root,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria,4EY8S@85014|Glycomycetales	201174|Actinobacteria	E	Glycine cleavage system P-protein	-	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
CMS3_k127_4460022_1	1047013.AQSP01000134_gene1369	1.481e-182	587.0	COG0403@1|root,COG0403@2|Bacteria,2NQS4@2323|unclassified Bacteria	2|Bacteria	E	Glycine cleavage system P-protein	gcvPA	-	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
CMS3_k127_4460022_3	189753.AXAS01000056_gene5966	4.631e-57	203.0	COG1028@1|root,COG1028@2|Bacteria,1MXVZ@1224|Proteobacteria,2TVJW@28211|Alphaproteobacteria,3JXVQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100,1.1.1.304,1.1.1.76	ko:K00059,ko:K18009	ko00061,ko00333,ko00650,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00650,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R03707,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R09078,R10116,R10120,R10505,R11671	RC00029,RC00117,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_4479303_1	1123371.ATXH01000001_gene1278	7.026e-27	116.0	COG0071@1|root,COG0071@2|Bacteria,2GHTW@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS3_k127_4479303_3	999550.KI421507_gene2108	4.792e-07	57.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2UFRX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS3_k127_4479303_0	232348.ADXL01000055_gene1895	4.158e-75	264.0	COG0796@1|root,COG0796@2|Bacteria,1G0W6@1117|Cyanobacteria,1GZ94@1129|Synechococcus	1117|Cyanobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
CMS3_k127_4479303_2	426117.M446_5142	2.821e-08	61.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,1JZ33@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM extracellular solute-binding protein family 5	-	-	-	ko:K02035,ko:K13889	ko02010,ko02024,map02010,map02024	M00239,M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11	-	-	SBP_bac_5
CMS3_k127_4486848_1	1379698.RBG1_1C00001G0322	3.164e-51	202.0	COG2385@1|root,COG2385@2|Bacteria,2NPRR@2323|unclassified Bacteria	2|Bacteria	D	Stage II sporulation protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
CMS3_k127_4486848_0	518766.Rmar_2058	1.921e-80	282.0	COG2377@1|root,COG2377@2|Bacteria,4NFZU@976|Bacteroidetes,1FIM0@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
CMS3_k127_4487800_2	1041139.KB902683_gene2759	8.863e-51	192.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria,4BA0J@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
CMS3_k127_4487800_0	1502851.FG93_06077	2.695e-63	228.0	COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2U874@28211|Alphaproteobacteria,3JRK1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2
CMS3_k127_4487800_1	247490.KSU1_C0511	2.289e-61	222.0	COG0624@1|root,COG0624@2|Bacteria,2IYA5@203682|Planctomycetes	203682|Planctomycetes	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS3_k127_4494131_0	243164.DET1552	1.925e-140	467.0	COG1961@1|root,COG1961@2|Bacteria,2G7BH@200795|Chloroflexi,34DMJ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
CMS3_k127_4494131_1	517418.Ctha_1321	2.812e-64	229.0	COG1657@1|root,COG1657@2|Bacteria,1FEQI@1090|Chlorobi	1090|Chlorobi	I	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
CMS3_k127_4494131_2	1519464.HY22_07320	2.272e-18	98.0	COG1196@1|root,COG1196@2|Bacteria,1FESH@1090|Chlorobi	1090|Chlorobi	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4498429_2	1340493.JNIF01000003_gene3106	4.998e-34	135.0	COG0399@1|root,COG0399@2|Bacteria,3Y2G1@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS3_k127_4498429_0	997296.PB1_06782	1.387e-44	172.0	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,4HH2N@91061|Bacilli,1ZCWR@1386|Bacillus	91061|Bacilli	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
CMS3_k127_4498429_1	521098.Aaci_2734	1.692e-44	177.0	COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,4HG1X@91061|Bacilli,279SY@186823|Alicyclobacillaceae	91061|Bacilli	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
CMS3_k127_4519534_1	1382359.JIAL01000001_gene2266	3.368e-34	146.0	COG0265@1|root,COG0265@2|Bacteria,3Y7GN@57723|Acidobacteria,2JM8V@204432|Acidobacteriia	204432|Acidobacteriia	O	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4519534_0	1096546.WYO_4178	1.741e-96	327.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TT1R@28211|Alphaproteobacteria,1JTWJ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	PFAM pyruvate carboxyltransferase	hmgL	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
CMS3_k127_4519534_2	1123229.AUBC01000010_gene3392	5.527e-08	57.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,3JQQI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Belongs to the peptidase S1C family	MA20_15480	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_4530122_5	1298593.TOL_2770	3.395e-33	128.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1XIE9@135619|Oceanospirillales	135619|Oceanospirillales	C	belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
CMS3_k127_4530122_1	1254432.SCE1572_02795	3.029e-126	423.0	COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_4530122_2	448385.sce6976	2.867e-110	384.0	COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	-	-	-	ko:K01932,ko:K03301	-	-	-	-	ko00000,ko01000	2.A.12	-	-	Glyco_transf_4,Glycos_transf_1,HEAT_2,TLC
CMS3_k127_4530122_0	243231.GSU2317	6.456e-189	608.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,43S4X@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
CMS3_k127_4530122_4	243231.GSU3292	1.078e-35	141.0	COG0735@1|root,COG0735@2|Bacteria,1N0HW@1224|Proteobacteria,42TU6@68525|delta/epsilon subdivisions,2WPZ1@28221|Deltaproteobacteria,43VCX@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Ferric uptake regulator family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS3_k127_4530122_3	211165.AJLN01000141_gene2399	1.176e-46	175.0	COG0783@1|root,COG0783@2|Bacteria,1G54E@1117|Cyanobacteria,1JJKM@1189|Stigonemataceae	1117|Cyanobacteria	P	Ferritin-like domain	dps	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
CMS3_k127_4535228_0	1158150.KB906246_gene1915	1.743e-231	728.0	COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,1T2GI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1,1.8.5.3	ko:K00370,ko:K07306,ko:K17050	ko00910,ko00920,ko01120,ko02020,map00910,map00920,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497,R09501	RC02555,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.3,5.A.3.8	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
CMS3_k127_4535228_1	1255043.TVNIR_1120	3.992e-173	549.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,1RNMJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	nitrate reductase beta subunit	-	-	1.7.5.1	ko:K00371,ko:K17051	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Fer4_11
CMS3_k127_4535228_4	178306.PAE3613	2.27e-10	71.0	arCOG04198@1|root,arCOG04198@2157|Archaea	2157|Archaea	S	Ethylbenzene dehydrogenase	-	-	-	ko:K17052	-	-	-	-	ko00000,ko02000	5.A.3.8	-	-	EB_dh
CMS3_k127_4535228_5	1255043.TVNIR_1121	0.0002771	51.0	COG2180@1|root,COG2180@2|Bacteria,1NDAU@1224|Proteobacteria	1224|Proteobacteria	C	nitrate reductase molybdenum cofactor assembly chaperone	-	-	-	ko:K17052	-	-	-	-	ko00000,ko02000	5.A.3.8	-	-	EB_dh
CMS3_k127_4535228_2	96561.Dole_2719	1.39e-78	275.0	2CAK6@1|root,30G7R@2|Bacteria,1NVEF@1224|Proteobacteria,42ZJU@68525|delta/epsilon subdivisions,2WV1X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Poly (ADP-ribose) glycohydrolase (PARG)	-	-	-	-	-	-	-	-	-	-	-	-	PARG_cat
CMS3_k127_4535228_3	1254432.SCE1572_18260	7.176e-27	122.0	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,42MNW@68525|delta/epsilon subdivisions,2WWA5@28221|Deltaproteobacteria,2YX60@29|Myxococcales	28221|Deltaproteobacteria	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrome_CBB3,FTR1
CMS3_k127_4535762_3	331678.Cphamn1_2303	2.075e-66	248.0	COG5617@1|root,COG5617@2|Bacteria,1FDV6@1090|Chlorobi	1090|Chlorobi	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
CMS3_k127_4535762_2	867845.KI911784_gene700	1.701e-81	299.0	COG0438@1|root,COG0438@2|Bacteria,2G99J@200795|Chloroflexi,374RQ@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_4535762_1	479434.Sthe_0859	4.415e-96	328.0	COG0463@1|root,COG0463@2|Bacteria,2G5X5@200795|Chloroflexi,27XQE@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_4535762_0	582515.KR51_00017720	1.133e-102	343.0	COG0451@1|root,COG0451@2|Bacteria,1G0GJ@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM NAD dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS3_k127_4537035_2	1120949.KB903325_gene3006	1.567e-05	57.0	COG5662@1|root,COG5662@2|Bacteria,2HUDT@201174|Actinobacteria,4DEJK@85008|Micromonosporales	201174|Actinobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
CMS3_k127_4537035_1	1047013.AQSP01000079_gene2042	2.536e-28	123.0	COG1595@1|root,COG1595@2|Bacteria,2NQ4E@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_4537035_0	880073.Calab_3018	1.213e-215	682.0	COG4799@1|root,COG4799@2|Bacteria,2NNWQ@2323|unclassified Bacteria	2|Bacteria	I	carboxyl transferase	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
CMS3_k127_4541269_2	383372.Rcas_2505	3.958e-67	249.0	COG1807@1|root,COG1807@2|Bacteria,2G8IK@200795|Chloroflexi,375EI@32061|Chloroflexia	32061|Chloroflexia	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4541269_5	357808.RoseRS_0687	3.426e-08	66.0	COG0457@1|root,COG5635@1|root,COG0457@2|Bacteria,COG5635@2|Bacteria,2G9QS@200795|Chloroflexi	200795|Chloroflexi	T	SMART RNA-processing protein HAT helix repeating-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,TPR_16,TPR_19,TPR_8
CMS3_k127_4541269_0	1463855.JOHV01000008_gene5348	6.212e-100	338.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS3_k127_4541269_4	1267535.KB906767_gene2130	1.954e-09	70.0	COG0457@1|root,COG0457@2|Bacteria,3Y4S2@57723|Acidobacteria	57723|Acidobacteria	NU	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
CMS3_k127_4541269_1	309798.COPRO5265_1310	1.318e-69	246.0	COG0388@1|root,COG0388@2|Bacteria,1V357@1239|Firmicutes,24GBQ@186801|Clostridia,42G0H@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.3	ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
CMS3_k127_4541269_6	428126.CLOSPI_00860	5.307e-06	59.0	COG4753@1|root,COG4753@2|Bacteria,1UK30@1239|Firmicutes	1239|Firmicutes	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS3_k127_4541269_3	999550.KI421507_gene1854	9.315e-10	62.0	COG3311@1|root,COG3311@2|Bacteria,1N72I@1224|Proteobacteria,2UM3F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	DNA binding domain, excisionase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
CMS3_k127_4551597_0	1125863.JAFN01000001_gene3190	2.307e-53	201.0	COG2199@1|root,COG3706@2|Bacteria,1QUKY@1224|Proteobacteria,42NYY@68525|delta/epsilon subdivisions,2WKIY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
CMS3_k127_4563301_1	1379698.RBG1_1C00001G0509	4.116e-143	466.0	COG1042@1|root,COG1042@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
CMS3_k127_4563301_0	869210.Marky_1642	3.826e-205	648.0	COG3033@1|root,COG3033@2|Bacteria,1WM62@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
CMS3_k127_4564071_2	292414.TM1040_0337	3.541e-42	159.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria,4NC77@97050|Ruegeria	28211|Alphaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
CMS3_k127_4564071_3	1387312.BAUS01000004_gene1427	7.221e-36	142.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2VR5S@28216|Betaproteobacteria,2KMQS@206350|Nitrosomonadales	206350|Nitrosomonadales	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
CMS3_k127_4564071_0	1125863.JAFN01000001_gene3029	7.187e-120	397.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ28@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	PFAM Type II secretion system protein E	pilT-1	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS3_k127_4564071_1	1379270.AUXF01000006_gene36	7.704e-108	359.0	COG0439@1|root,COG0439@2|Bacteria,1ZT0Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
CMS3_k127_45688_0	1267535.KB906767_gene880	1.934e-107	371.0	COG0612@1|root,COG0612@2|Bacteria,3Y2FB@57723|Acidobacteria,2JHWY@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16_C
CMS3_k127_45688_1	1340493.JNIF01000003_gene4422	1.424e-39	153.0	COG0612@1|root,COG0612@2|Bacteria,3Y3XF@57723|Acidobacteria	57723|Acidobacteria	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_4576107_0	448385.sce6491	3.269e-261	823.0	COG1964@1|root,COG1964@2|Bacteria,1QE02@1224|Proteobacteria,42M4B@68525|delta/epsilon subdivisions,2WJDI@28221|Deltaproteobacteria,2YZG3@29|Myxococcales	28221|Deltaproteobacteria	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
CMS3_k127_4576107_1	1454004.AW11_00525	1.987e-09	64.0	COG0596@1|root,COG0596@2|Bacteria,1QXP7@1224|Proteobacteria,2VPPV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS3_k127_457740_0	234267.Acid_7765	1.443e-67	243.0	COG0272@1|root,COG0272@2|Bacteria,3Y2UR@57723|Acidobacteria	57723|Acidobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
CMS3_k127_457740_1	1519464.HY22_11245	2.134e-18	95.0	COG4775@1|root,COG4775@2|Bacteria,1FEGD@1090|Chlorobi	1090|Chlorobi	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
CMS3_k127_458581_0	439235.Dalk_2389	1.726e-142	465.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2MHR7@213118|Desulfobacterales	28221|Deltaproteobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	algC	-	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS3_k127_458581_1	471223.GWCH70_2482	4.803e-65	231.0	COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,4HAVR@91061|Bacilli,1WEX8@129337|Geobacillus	91061|Bacilli	F	uridine kinase activity	udk	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
CMS3_k127_458581_2	1499967.BAYZ01000193_gene3921	2.125e-57	210.0	COG0382@1|root,COG0382@2|Bacteria,2NNVJ@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	ubiA	-	-	-	-	-	-	-	-	-	-	-	UbiA
CMS3_k127_4635080_1	945713.IALB_0376	4.491e-65	229.0	COG1207@1|root,COG1207@2|Bacteria	2|Bacteria	M	glucosamine-1-phosphate N-acetyltransferase activity	glmU	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_4
CMS3_k127_4635080_3	1499967.BAYZ01000012_gene2485	4.175e-34	133.0	COG4577@1|root,COG4577@2|Bacteria,2NRBW@2323|unclassified Bacteria	2|Bacteria	CQ	COGs COG4577 Carbon dioxide concentrating mechanism carboxysome shell protein	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
CMS3_k127_4635080_4	215803.DB30_1142	7.071e-24	104.0	COG4576@1|root,COG4576@2|Bacteria,1RIK4@1224|Proteobacteria,4362N@68525|delta/epsilon subdivisions,2X9F2@28221|Deltaproteobacteria,2Z246@29|Myxococcales	28221|Deltaproteobacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	-	-	-	-	-	-	-	-	-	-	-	-	EutN_CcmL
CMS3_k127_4635080_0	1499967.BAYZ01000013_gene6421	3.825e-147	481.0	COG1012@1|root,COG1012@2|Bacteria,2NQI9@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde dehydrogenase family	eutE	GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.87	ko:K04021,ko:K13922	ko00620,ko00640,ko01100,ko01120,map00620,map00640,map01100,map01120	-	R00228,R09097	RC00004,RC00184,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh
CMS3_k127_4635080_2	349161.Dred_3269	2.248e-35	153.0	COG4577@1|root,COG4577@2|Bacteria,1UKDS@1239|Firmicutes,24IS5@186801|Clostridia,263Q8@186807|Peptococcaceae	186801|Clostridia	CQ	Carbon dioxide concentrating mechanism carboxysome shell protein	csoS1C	-	-	-	-	-	-	-	-	-	-	-	BMC
CMS3_k127_4635080_6	234267.Acid_0324	1.954e-08	64.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	eutN	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
CMS3_k127_4635080_5	880073.Calab_3434	6.231e-14	74.0	COG4576@1|root,COG4576@2|Bacteria,2NS06@2323|unclassified Bacteria	2|Bacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	eutN	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
CMS3_k127_4663050_0	882.DVU_2359	3.611e-55	218.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YU@28221|Deltaproteobacteria,2MGPQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Sigma-54 interaction domain	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,PAS_9,Sigma54_activat
CMS3_k127_4663727_1	1487953.JMKF01000050_gene1926	3.065e-76	266.0	2CCCK@1|root,2Z7UH@2|Bacteria,1GGQS@1117|Cyanobacteria,1HH0S@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4663727_0	640511.BC1002_5570	6.115e-113	399.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae	28216|Betaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
CMS3_k127_4674363_0	215803.DB30_7007	5.437e-89	308.0	COG1181@1|root,COG2940@1|root,COG1181@2|Bacteria,COG2940@2|Bacteria,1Q3H4@1224|Proteobacteria,4399M@68525|delta/epsilon subdivisions,2X4H1@28221|Deltaproteobacteria,2YZ01@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
CMS3_k127_4674363_1	452637.Oter_3038	2.599e-82	289.0	2BSEF@1|root,32MGE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4674363_2	1485544.JQKP01000001_gene879	1.239e-17	88.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2VISD@28216|Betaproteobacteria,44VAU@713636|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM membrane bound O-acyl transferase MBOAT family protein	pacA	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
CMS3_k127_4675767_3	1121904.ARBP01000028_gene1685	3.686e-06	51.0	COG3047@1|root,COG3047@2|Bacteria,4NWCT@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4675767_1	1267534.KB906756_gene341	3.442e-29	123.0	2E3RZ@1|root,32YPK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4675767_2	1121373.KB903664_gene2660	1.553e-12	77.0	2C7HJ@1|root,31BFZ@2|Bacteria,4NRGQ@976|Bacteroidetes,47WSM@768503|Cytophagia	976|Bacteroidetes	S	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
CMS3_k127_4675767_0	880072.Desac_2078	1.282e-35	156.0	COG4775@1|root,COG4775@2|Bacteria,1QX52@1224|Proteobacteria,43CEZ@68525|delta/epsilon subdivisions,2X7PY@28221|Deltaproteobacteria,2MRBQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
CMS3_k127_4677199_1	926556.Echvi_0018	4.91e-47	178.0	COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,47PDZ@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA,PD40
CMS3_k127_4677199_0	644966.Tmar_0304	2.787e-67	247.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,25CC3@186801|Clostridia	186801|Clostridia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	dat	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
CMS3_k127_4677199_2	525897.Dbac_1126	3.207e-36	141.0	COG0517@1|root,COG0517@2|Bacteria,1N0EB@1224|Proteobacteria,42W96@68525|delta/epsilon subdivisions,2WP5S@28221|Deltaproteobacteria,2MC10@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	ko:K07168	-	-	-	-	ko00000	-	-	-	CBS
CMS3_k127_4677199_3	985665.HPL003_09305	1.441e-23	114.0	COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,4HFNQ@91061|Bacilli,26SCR@186822|Paenibacillaceae	91061|Bacilli	C	glycerophosphoryl diester phosphodiesterase	yqiK	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS3_k127_4680976_0	1047013.AQSP01000092_gene323	4.204e-94	312.0	COG0798@1|root,COG0798@2|Bacteria,2NNWJ@2323|unclassified Bacteria	2|Bacteria	P	Sodium Bile acid symporter family	arsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
CMS3_k127_4680976_1	882.DVU_1646	2.51e-51	186.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,42RQI@68525|delta/epsilon subdivisions,2WNEC@28221|Deltaproteobacteria,2MBFG@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM Protein-tyrosine phosphatase, low molecular weight	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
CMS3_k127_4680976_2	391625.PPSIR1_42079	1.85e-48	179.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,42SP5@68525|delta/epsilon subdivisions,2WP39@28221|Deltaproteobacteria,2YUQU@29|Myxococcales	28221|Deltaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
CMS3_k127_470261_0	292459.STH3140	4.094e-85	296.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia	186801|Clostridia	J	elongation factor g	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS3_k127_470261_1	330214.NIDE0890	7.057e-10	66.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	3.1.21.3	ko:K01153,ko:K05789,ko:K07011,ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01005,ko02000,ko02048	8.A.3.1	-	-	GNVR,Wzz
CMS3_k127_4709968_2	1121422.AUMW01000013_gene1512	6.961e-08	61.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,266TR@186807|Peptococcaceae	186801|Clostridia	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07668,ko:K07775	ko02020,map02020	M00458,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_4709968_0	204669.Acid345_1733	6.668e-44	184.0	COG5000@1|root,COG5000@2|Bacteria,3Y32D@57723|Acidobacteria,2JIN2@204432|Acidobacteriia	2|Bacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_4709968_1	1305732.JAGG01000001_gene268	1.359e-10	74.0	COG0747@1|root,COG0747@2|Bacteria,2GK4Y@201174|Actinobacteria,4FTC4@85023|Microbacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS3_k127_4711611_1	247490.KSU1_C0659	2.871e-101	363.0	COG0612@1|root,COG0612@2|Bacteria,2IWSI@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_4711611_0	1232437.KL661961_gene3053	2.181e-164	528.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N38@68525|delta/epsilon subdivisions,2WK56@28221|Deltaproteobacteria,2MHP9@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Di-haem cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,Cytochrom_C
CMS3_k127_4711611_2	1121930.AQXG01000004_gene2870	1.059e-07	57.0	COG0737@1|root,COG0737@2|Bacteria	2|Bacteria	F	nucleotide catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Cytochrome_C554,SBP_bac_8,SLH
CMS3_k127_4728157_2	643562.Daes_3232	2.078e-16	91.0	COG0457@1|root,COG0457@2|Bacteria,1N336@1224|Proteobacteria,42UTQ@68525|delta/epsilon subdivisions,2WQW8@28221|Deltaproteobacteria,2MCP0@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	SMART Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
CMS3_k127_4728157_1	485916.Dtox_1077	6.93e-28	120.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,2605V@186807|Peptococcaceae	186801|Clostridia	K	PFAM response regulator receiver	phoB	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_4728157_0	357808.RoseRS_1736	1.707e-58	230.0	COG1413@1|root,COG1674@1|root,COG5635@1|root,COG1413@2|Bacteria,COG1674@2|Bacteria,COG5635@2|Bacteria,2G8R0@200795|Chloroflexi,3766B@32061|Chloroflexia	32061|Chloroflexia	CDT	Armadillo/beta-catenin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS3_k127_4729277_2	373903.Hore_02320	3.404e-15	80.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,24RIE@186801|Clostridia,3WAWT@53433|Halanaerobiales	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
CMS3_k127_4729277_1	1463821.JOGR01000009_gene1918	1.572e-37	151.0	COG4122@1|root,COG4122@2|Bacteria,2GP7A@201174|Actinobacteria,4EYZM@85014|Glycomycetales	201174|Actinobacteria	S	O-methyltransferase	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
CMS3_k127_4729277_0	1303518.CCALI_02195	2.045e-43	168.0	COG0210@1|root,COG0210@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03656,ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
CMS3_k127_4730392_1	479434.Sthe_3006	1.467e-11	71.0	COG0318@1|root,COG0318@2|Bacteria,2G5Q8@200795|Chloroflexi,27YVR@189775|Thermomicrobia	189775|Thermomicrobia	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
CMS3_k127_4730392_2	1201288.M900_1808	3.906e-08	64.0	2EQTX@1|root,33IDK@2|Bacteria,1NJ7Q@1224|Proteobacteria,42XE5@68525|delta/epsilon subdivisions,2MTFJ@213481|Bdellovibrionales,2WTE3@28221|Deltaproteobacteria	213481|Bdellovibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SirB
CMS3_k127_4730392_0	765420.OSCT_1275	1.414e-36	152.0	COG1807@1|root,COG1807@2|Bacteria,2G8IK@200795|Chloroflexi,375EI@32061|Chloroflexia	32061|Chloroflexia	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4742521_1	330214.NIDE0755	3.077e-70	252.0	COG0768@1|root,COG0768@2|Bacteria,3J0FH@40117|Nitrospirae	40117|Nitrospirae	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
CMS3_k127_4742521_0	760568.Desku_1150	2.036e-114	387.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,260X6@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS3_k127_4742521_2	187272.Mlg_2197	3.089e-63	233.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1WWTC@135613|Chromatiales	135613|Chromatiales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS3_k127_4762987_1	391625.PPSIR1_12373	1.904e-103	346.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,42M1K@68525|delta/epsilon subdivisions,2WJRH@28221|Deltaproteobacteria,2YUBV@29|Myxococcales	28221|Deltaproteobacteria	E	Aminopeptidase P, N-terminal domain	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
CMS3_k127_4762987_3	1123368.AUIS01000013_gene832	1.985e-21	105.0	COG4911@1|root,COG4911@2|Bacteria,1NPJ8@1224|Proteobacteria,1T8JU@1236|Gammaproteobacteria,2ND17@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
CMS3_k127_4762987_0	926550.CLDAP_07090	6.109e-154	513.0	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
CMS3_k127_4762987_2	880071.Fleli_3626	1.733e-27	129.0	COG0697@1|root,COG0697@2|Bacteria,4NGZ3@976|Bacteroidetes,47PHD@768503|Cytophagia	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_4770015_2	1232436.CAPF01000016_gene624	5.55e-45	168.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4CVKY@84998|Coriobacteriia	84998|Coriobacteriia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
CMS3_k127_4770015_1	264732.Moth_0890	3.183e-57	210.0	COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,24824@186801|Clostridia,42EU9@68295|Thermoanaerobacterales	186801|Clostridia	S	domain protein	yicC	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
CMS3_k127_4770015_0	1131269.AQVV01000001_gene1399	2.183e-90	307.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	pksB	GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
CMS3_k127_4770538_10	391625.PPSIR1_09331	1.613e-26	125.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria	2|Bacteria	I	3-hydroxyacyl-CoA dehydrogenase	paaH	GO:0003674,GO:0003824,GO:0003857,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0008691,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	iECO103_1326.ECO103_1532,iJN746.PP_3282	3HCDH,3HCDH_N
CMS3_k127_4770538_7	768066.HELO_3947	1.666e-76	273.0	COG0183@1|root,COG0183@2|Bacteria,1MXYM@1224|Proteobacteria,1S0V9@1236|Gammaproteobacteria,1XN9H@135619|Oceanospirillales	135619|Oceanospirillales	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_4770538_4	1121405.dsmv_3638	3.166e-120	398.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria	1224|Proteobacteria	I	Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
CMS3_k127_4770538_11	909663.KI867150_gene1036	1.045e-20	98.0	COG1545@1|root,COG1545@2|Bacteria,1N4S9@1224|Proteobacteria,42U3D@68525|delta/epsilon subdivisions,2WQNA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
CMS3_k127_4770538_3	706587.Desti_2452	2.055e-124	409.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_4770538_6	269799.Gmet_2059	2.286e-92	310.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,42QAM@68525|delta/epsilon subdivisions,2WM04@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_4770538_12	646529.Desaci_2258	1.247e-18	96.0	28ISQ@1|root,33DSE@2|Bacteria,1VQKR@1239|Firmicutes,24WZ0@186801|Clostridia,2662P@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4770538_0	1379698.RBG1_1C00001G1165	6.321e-293	918.0	COG0495@1|root,COG0495@2|Bacteria,2NNQH@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_2300	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
CMS3_k127_4770538_13	880073.Calab_3215	7.001e-18	99.0	COG0366@1|root,COG0708@1|root,COG0366@2|Bacteria,COG0708@2|Bacteria,2NREA@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolase family 70	-	-	3.1.11.2,3.2.1.1	ko:K01142,ko:K01176	ko00500,ko01100,ko03410,ko04973,map00500,map01100,map03410,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000,ko03400	-	GH13	-	Alpha-amylase,CBM_25,DUF1939,He_PIG
CMS3_k127_4770538_9	485918.Cpin_1703	2.51e-32	134.0	2B9NZ@1|root,3231D@2|Bacteria,4NR0T@976|Bacteroidetes,1IUNH@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1579)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1579
CMS3_k127_4770538_5	1254432.SCE1572_37590	5.285e-96	330.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,438CB@68525|delta/epsilon subdivisions,2X3MN@28221|Deltaproteobacteria,2YWIY@29|Myxococcales	28221|Deltaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	-
CMS3_k127_4770538_2	234267.Acid_7662	2.777e-149	484.0	COG0160@1|root,COG0160@2|Bacteria,3Y4EV@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.55	ko:K00823,ko:K15372	ko00250,ko00410,ko00430,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00430,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R01684	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_4770538_8	1192034.CAP_8584	2.908e-74	250.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,42M1Y@68525|delta/epsilon subdivisions,2WP4Z@28221|Deltaproteobacteria,2YU7V@29|Myxococcales	28221|Deltaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.1.53,3.5.1.6	ko:K01431,ko:K12251	ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100	M00046	R00905,R01152,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
CMS3_k127_4784367_1	948106.AWZT01000053_gene1579	3.263e-63	222.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2VMJ9@28216|Betaproteobacteria,1K26K@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Uncharacterized protein family (UPF0051)	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
CMS3_k127_4784367_0	472759.Nhal_0691	3.996e-177	565.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1WWTN@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,SufE
CMS3_k127_4784367_2	1198232.CYCME_1545	6.557e-50	181.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,461GC@72273|Thiotrichales	72273|Thiotrichales	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
CMS3_k127_4784367_3	1191523.MROS_0340	1.447e-33	139.0	COG2151@1|root,COG2151@2|Bacteria	2|Bacteria	L	metal-sulfur cluster biosynthetic enzyme	paaD	-	-	ko:K02612,ko:K03593	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko03029,ko03036	-	-	-	FeS_assembly_P
CMS3_k127_4784981_2	1128421.JAGA01000002_gene1425	3.144e-12	78.0	COG0791@1|root,COG0791@2|Bacteria,2NREJ@2323|unclassified Bacteria	2|Bacteria	M	NlpC/P60 family	ykfC	-	3.4.14.13	ko:K20742,ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SH3_3
CMS3_k127_4784981_1	1379698.RBG1_1C00001G1368	2.933e-18	99.0	COG4219@1|root,COG4219@2|Bacteria,2NS3V@2323|unclassified Bacteria	2|Bacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_6,DUF4309,DUF5301
CMS3_k127_4784981_0	568816.Acin_1776	1.294e-21	109.0	COG1538@1|root,COG1538@2|Bacteria,1TRDS@1239|Firmicutes,4H2S7@909932|Negativicutes	909932|Negativicutes	MU	outer membrane efflux protein	tolC	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS3_k127_4797567_0	1380763.BG53_03300	1.39e-157	511.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,4H9PN@91061|Bacilli,26TDB@186822|Paenibacillaceae	91061|Bacilli	I	catalyzes the conversion of acetate and CoA to acetyl-CoA	acsA_1	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
CMS3_k127_4797567_1	1399115.U719_06360	8.803e-68	246.0	COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,4HAN8@91061|Bacilli,3WEPY@539002|Bacillales incertae sedis	91061|Bacilli	C	belongs to the iron- containing alcohol dehydrogenase family	adhE	-	1.1.1.1,1.2.1.10	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS00885	Aldedh,Fe-ADH
CMS3_k127_4802571_0	555079.Toce_1711	9.675e-42	172.0	COG3437@1|root,COG3437@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia,42J5U@68295|Thermoanaerobacterales	186801|Clostridia	KT	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	GGDEF,HD,HD_5,Hpt,Response_reg
CMS3_k127_4807581_0	246197.MXAN_6555	6.943e-191	607.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,42UR5@68525|delta/epsilon subdivisions,2WQET@28221|Deltaproteobacteria,2YU29@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolase family 1	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
CMS3_k127_4833685_2	502025.Hoch_6665	9.787e-05	45.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2YXKT@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_4833685_1	406327.Mevan_0058	7.169e-07	56.0	COG0535@1|root,arCOG02736@2157|Archaea,2Y1UX@28890|Euryarchaeota,23RNH@183939|Methanococci	183939|Methanococci	S	PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
CMS3_k127_4833685_0	404589.Anae109_2697	9.26e-46	179.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,42SE9@68525|delta/epsilon subdivisions,2WMQE@28221|Deltaproteobacteria,2YVJ7@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
CMS3_k127_4843536_3	357808.RoseRS_2867	1.096e-12	80.0	COG1816@1|root,COG1816@2|Bacteria,2G6AT@200795|Chloroflexi,374T6@32061|Chloroflexia	32061|Chloroflexia	F	PFAM adenosine AMP deaminase	-	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
CMS3_k127_4843536_0	1379698.RBG1_1C00001G1066	1.601e-130	433.0	COG0260@1|root,COG0260@2|Bacteria,2NNKH@2323|unclassified Bacteria	2|Bacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141	3.4.11.1,3.4.11.5	ko:K01255,ko:K01259	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00135,R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
CMS3_k127_4843536_2	357808.RoseRS_3027	1.055e-18	98.0	COG1184@1|root,COG1184@2|Bacteria,2G9CC@200795|Chloroflexi,3762Q@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the eIF-2B alpha beta delta subunits family	-	-	-	ko:K03680	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	IF-2B
CMS3_k127_4843536_1	251229.Chro_0793	1.576e-39	158.0	COG0030@1|root,COG0030@2|Bacteria	2|Bacteria	J	rRNA (adenine-N6,N6-)-dimethyltransferase activity	ksgA	-	2.1.1.182,2.1.1.184	ko:K00561,ko:K02528	-	-	R10716	RC00003,RC03257	br01600,ko00000,ko01000,ko01504,ko03009	-	-	-	Methyltransf_21,RrnaAD
CMS3_k127_484414_1	945713.IALB_0695	2.826e-74	280.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS3_k127_484414_0	1047013.AQSP01000079_gene2041	2.712e-182	608.0	COG0841@1|root,COG0841@2|Bacteria,2NQI6@2323|unclassified Bacteria	2|Bacteria	V	AcrB/AcrD/AcrF family	mdtC	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS3_k127_4863443_0	1379698.RBG1_1C00001G1772	1.815e-27	121.0	COG0457@1|root,COG0457@2|Bacteria,2NQ3H@2323|unclassified Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2
CMS3_k127_4885918_11	1410617.JHXH01000010_gene2030	6.419e-15	74.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,3WGI1@541000|Ruminococcaceae	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
CMS3_k127_4885918_5	373903.Hore_01160	5.864e-41	154.0	COG0051@1|root,COG0051@2|Bacteria,1V6C9@1239|Firmicutes,24JDC@186801|Clostridia,3WAR4@53433|Halanaerobiales	186801|Clostridia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
CMS3_k127_4885918_2	429009.Adeg_1524	1.078e-65	231.0	COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,42FAS@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
CMS3_k127_4885918_4	1279009.ADICEAN_00791	7.889e-45	179.0	COG0088@1|root,COG0088@2|Bacteria,4NEWZ@976|Bacteroidetes,47J8V@768503|Cytophagia	976|Bacteroidetes	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
CMS3_k127_4885918_9	706587.Desti_5264	1.209e-22	102.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,42V3Y@68525|delta/epsilon subdivisions,2WRMX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
CMS3_k127_4885918_0	644282.Deba_2935	5.541e-122	398.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,42MBV@68525|delta/epsilon subdivisions,2WIRE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
CMS3_k127_4885918_6	1340493.JNIF01000003_gene3211	9.439e-37	141.0	COG0185@1|root,COG0185@2|Bacteria,3Y560@57723|Acidobacteria	57723|Acidobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
CMS3_k127_4885918_7	351607.Acel_0311	1.158e-27	117.0	COG0091@1|root,COG0091@2|Bacteria,2IM3J@201174|Actinobacteria,4ET3T@85013|Frankiales	201174|Actinobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
CMS3_k127_4885918_1	243231.GSU2851	1.685e-78	278.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,42N5W@68525|delta/epsilon subdivisions,2WIU3@28221|Deltaproteobacteria,43T5Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
CMS3_k127_4885918_3	289376.THEYE_A1439	2.165e-59	208.0	COG0197@1|root,COG0197@2|Bacteria,3J0H7@40117|Nitrospirae	40117|Nitrospirae	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
CMS3_k127_4885918_12	706587.Desti_5270	7.552e-06	55.0	COG0255@1|root,COG0255@2|Bacteria,1Q1R3@1224|Proteobacteria,42WYX@68525|delta/epsilon subdivisions,2WSTS@28221|Deltaproteobacteria,2MSF9@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
CMS3_k127_4885918_8	555088.DealDRAFT_1514	1.009e-25	109.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,42K48@68298|Syntrophomonadaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
CMS3_k127_4885918_10	350688.Clos_0502	1.506e-15	82.0	COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,24H98@186801|Clostridia,36IUH@31979|Clostridiaceae	186801|Clostridia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
CMS3_k127_4905102_1	264732.Moth_1809	5.563e-225	714.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,42FTG@68295|Thermoanaerobacterales	186801|Clostridia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48,DUF3459
CMS3_k127_4905102_0	1382356.JQMP01000004_gene488	5.267e-252	782.0	COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi,27XZS@189775|Thermomicrobia	189775|Thermomicrobia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
CMS3_k127_4906282_4	1260251.SPISAL_05480	1.005e-08	66.0	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1WY02@135613|Chromatiales	135613|Chromatiales	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
CMS3_k127_4906282_2	472175.EL18_01057	3.301e-40	159.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2TZPK@28211|Alphaproteobacteria,43HBX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF502)	MA20_12960	-	-	-	-	-	-	-	-	-	-	-	DUF502
CMS3_k127_4906282_1	574087.Acear_0620	2.819e-61	229.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3WAE6@53433|Halanaerobiales	186801|Clostridia	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
CMS3_k127_4906282_3	1278073.MYSTI_05194	5.549e-16	89.0	COG0319@1|root,COG0662@1|root,COG0319@2|Bacteria,COG0662@2|Bacteria,1MZ67@1224|Proteobacteria,42W3M@68525|delta/epsilon subdivisions,2WRMB@28221|Deltaproteobacteria,2YYJR@29|Myxococcales	28221|Deltaproteobacteria	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	Cupin_2,UPF0054
CMS3_k127_4906282_0	562970.Btus_0771	4.139e-97	327.0	COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,4HBD5@91061|Bacilli,2785Z@186823|Alicyclobacillaceae	91061|Bacilli	T	AAA domain	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
CMS3_k127_4911925_0	290397.Adeh_1209	2.66e-145	496.0	COG0457@1|root,COG4262@1|root,COG0457@2|Bacteria,COG4262@2|Bacteria,1QTYC@1224|Proteobacteria,42Q43@68525|delta/epsilon subdivisions,2WKQF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
CMS3_k127_4911925_1	234267.Acid_2212	4.601e-89	301.0	COG2304@1|root,COG2304@2|Bacteria,3Y33Z@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase M64 N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	M64_N,Peptidase_M64
CMS3_k127_4912137_1	1499967.BAYZ01000153_gene1545	8.322e-42	173.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
CMS3_k127_4912137_0	234267.Acid_0950	1.57e-56	220.0	COG0515@1|root,COG0515@2|Bacteria,3Y4M5@57723|Acidobacteria	57723|Acidobacteria	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_4912137_2	745776.DGo_CA0986	2.735e-05	50.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	rpoE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0006970,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_4920860_1	1382356.JQMP01000003_gene2357	2.768e-83	294.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2G5Q5@200795|Chloroflexi,27Y10@189775|Thermomicrobia	189775|Thermomicrobia	EU	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS3_k127_4920860_0	644966.Tmar_1299	4.584e-120	396.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia,3WD3X@538999|Clostridiales incertae sedis	186801|Clostridia	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
CMS3_k127_4920860_2	1379698.RBG1_1C00001G0517	2.585e-27	114.0	COG0489@1|root,COG0489@2|Bacteria,2NNX1@2323|unclassified Bacteria	2|Bacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
CMS3_k127_4920860_3	547559.Nmag_3434	0.0006487	51.0	COG3919@1|root,arCOG06897@2157|Archaea,2XUFQ@28890|Euryarchaeota,23SN4@183963|Halobacteria	183963|Halobacteria	S	COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
CMS3_k127_4928899_4	1121456.ATVA01000012_gene2757	6.121e-11	64.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,42SD5@68525|delta/epsilon subdivisions,2WP5M@28221|Deltaproteobacteria,2MBR8@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
CMS3_k127_4928899_2	941639.BCO26_0151	2.376e-40	153.0	COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,4HH3B@91061|Bacilli,1ZG6R@1386|Bacillus	91061|Bacilli	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
CMS3_k127_4928899_0	760011.Spico_0690	2.616e-80	279.0	COG0052@1|root,COG0052@2|Bacteria,2J5GZ@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
CMS3_k127_4928899_1	1262914.BN533_01480	1.008e-75	259.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,4H35I@909932|Negativicutes	909932|Negativicutes	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
CMS3_k127_4928899_3	1267535.KB906767_gene4503	1.645e-35	138.0	COG0528@1|root,COG0528@2|Bacteria,3Y2FI@57723|Acidobacteria,2JISS@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
CMS3_k127_4953274_2	504472.Slin_5366	9.639e-22	111.0	28HMX@1|root,2Z7WB@2|Bacteria,4NFY2@976|Bacteroidetes,47MX8@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_4953274_1	504472.Slin_5365	9.853e-61	235.0	COG1131@1|root,COG1131@2|Bacteria,4NJ0D@976|Bacteroidetes,47K40@768503|Cytophagia	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_4953274_0	880073.Calab_3685	4.732e-188	613.0	COG0473@1|root,COG0473@2|Bacteria,2NNUM@2323|unclassified Bacteria	2|Bacteria	CE	Isocitrate/isopropylmalate dehydrogenase	dlpA	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh,MoCF_biosynth,RraA-like
CMS3_k127_495814_3	497964.CfE428DRAFT_0285	5.072e-14	72.0	COG0393@1|root,COG0393@2|Bacteria,46WT4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
CMS3_k127_495814_1	301.JNHE01000028_gene786	2.174e-89	313.0	COG0834@1|root,COG0834@2|Bacteria,1NN6F@1224|Proteobacteria,1RZ35@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	ko:K02030,ko:K10036	ko02010,map02010	M00227,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.2	-	-	Lig_chan,SBP_bac_3
CMS3_k127_495814_4	66869.JNXG01000004_gene2690	2.322e-05	55.0	COG5464@1|root,COG5464@2|Bacteria,2HYF7@201174|Actinobacteria,41CZB@629295|Streptomyces griseus group	201174|Actinobacteria	S	transposase or invertase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_495814_0	404589.Anae109_3441	1.252e-94	319.0	COG4690@1|root,COG4690@2|Bacteria,1R4YQ@1224|Proteobacteria,42NQZ@68525|delta/epsilon subdivisions,2WMGS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM peptidase U34 dipeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
CMS3_k127_496683_1	243233.MCA0142	7.796e-90	302.0	COG0387@1|root,COG0387@2|Bacteria,1N1MR@1224|Proteobacteria,1S1GI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
CMS3_k127_496683_3	65393.PCC7424_0613	2.951e-44	166.0	COG4067@1|root,COG4067@2|Bacteria,1G6KI@1117|Cyanobacteria,3KI1C@43988|Cyanothece	1117|Cyanobacteria	O	Putative ATP-dependant zinc protease	-	-	-	-	-	-	-	-	-	-	-	-	Zn_protease
CMS3_k127_496683_0	56110.Oscil6304_5627	2.563e-151	486.0	COG0189@1|root,COG0189@2|Bacteria,1G0DT@1117|Cyanobacteria,1H6ZT@1150|Oscillatoriales	1117|Cyanobacteria	F	Belongs to the RimK family	rimK	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK,Zn_protease
CMS3_k127_496683_2	56110.Oscil6304_5628	5.057e-75	257.0	COG3608@1|root,COG3608@2|Bacteria,1G167@1117|Cyanobacteria,1H7T8@1150|Oscillatoriales	1117|Cyanobacteria	S	Succinylglutamate desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
CMS3_k127_500358_0	1385517.N800_00715	7.624e-220	721.0	COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,1XDD9@135614|Xanthomonadales	135614|Xanthomonadales	M	Ompa motb domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_500358_1	1499967.BAYZ01000159_gene546	6.491e-39	155.0	2EYYT@1|root,33S5J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5005381_4	1123487.KB892868_gene1175	2.819e-18	88.0	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,2VNEP@28216|Betaproteobacteria,2KXVX@206389|Rhodocyclales	206389|Rhodocyclales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
CMS3_k127_5005381_0	1379698.RBG1_1C00001G1666	2.355e-95	319.0	COG1136@1|root,COG1136@2|Bacteria,2NPA8@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_5005381_3	443144.GM21_0986	3.085e-65	239.0	COG0845@1|root,COG0845@2|Bacteria,1MUMV@1224|Proteobacteria,42PK1@68525|delta/epsilon subdivisions,2WJ65@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
CMS3_k127_5005381_2	1379698.RBG1_1C00001G1364	4.809e-85	298.0	COG0845@1|root,COG0845@2|Bacteria,2NP97@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	macA	-	-	ko:K02005,ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP
CMS3_k127_5005381_1	452637.Oter_1638	9.098e-95	315.0	COG1136@1|root,COG1136@2|Bacteria,46SI5@74201|Verrucomicrobia,3K7NZ@414999|Opitutae	414999|Opitutae	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_5005381_5	1298608.JCM18900_12431	3.883e-05	50.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,3NRC0@468|Moraxellaceae	1236|Gammaproteobacteria	V	ATPases associated with a variety of cellular activities	macB	-	-	ko:K05685	ko02010,map02010	M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
CMS3_k127_5016959_1	483219.LILAB_36190	1.837e-101	340.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2YUMA@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
CMS3_k127_5016959_0	1278073.MYSTI_04838	4.114e-143	467.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2YX7D@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA1	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_5017667_1	644076.SCH4B_2840	7.815e-06	54.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2TTZ4@28211|Alphaproteobacteria,4NAGJ@97050|Ruegeria	28211|Alphaproteobacteria	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
CMS3_k127_5017667_0	1278073.MYSTI_05079	7.364e-155	502.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2YUGG@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CMS3_k127_5035089_2	1454004.AW11_02488	2.005e-83	289.0	COG0394@1|root,COG0704@1|root,COG0394@2|Bacteria,COG0704@2|Bacteria	2|Bacteria	P	negative regulation of phosphate transmembrane transport	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	1.20.4.1,3.1.3.48	ko:K01104,ko:K02039,ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	PhoU
CMS3_k127_5035089_0	1454004.AW11_02487	8.04e-130	421.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria	28216|Betaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
CMS3_k127_5035089_1	1454004.AW11_02486	5.71e-98	329.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	P	phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
CMS3_k127_5035689_2	1082933.MEA186_21359	2.912e-31	126.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TUKX@28211|Alphaproteobacteria,43IHE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5035689_1	1121920.AUAU01000006_gene330	1.271e-61	223.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y6VR@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS3_k127_5035689_0	1449065.JMLL01000012_gene3494	1.208e-84	301.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TUKX@28211|Alphaproteobacteria,43IHE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	-
CMS3_k127_5039307_3	452637.Oter_4345	3.286e-06	52.0	COG1295@1|root,COG1295@2|Bacteria	2|Bacteria	S	lipopolysaccharide transmembrane transporter activity	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
CMS3_k127_5039307_1	1123033.ARNF01000060_gene15	3.887e-25	110.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,3NNIM@468|Moraxellaceae	1236|Gammaproteobacteria	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4,Fer4_9
CMS3_k127_5039307_2	1122921.KB898196_gene1179	1.035e-17	93.0	COG0084@1|root,COG0084@2|Bacteria,1TQUP@1239|Firmicutes,4HBEN@91061|Bacilli,26UES@186822|Paenibacillaceae	91061|Bacilli	L	TatD related DNase	M1-591	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
CMS3_k127_5039307_0	378806.STAUR_3879	6.175e-193	624.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2YTW8@29|Myxococcales	28221|Deltaproteobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
CMS3_k127_5059056_0	1387197.AWGA01000063_gene308	7.126e-68	243.0	COG0463@1|root,COG0463@2|Bacteria,1PVP4@1224|Proteobacteria,1RQUH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_5059056_1	1191523.MROS_0886	5.666e-43	173.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS3_k127_50772_4	653733.Selin_0884	1.82e-18	91.0	COG1005@1|root,COG1005@2|Bacteria	2|Bacteria	C	quinone binding	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
CMS3_k127_50772_1	1121403.AUCV01000026_gene2347	3.42e-49	188.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,43B19@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
CMS3_k127_50772_3	765914.ThisiDRAFT_0706	7.004e-20	101.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria,1WXHS@135613|Chromatiales	135613|Chromatiales	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
CMS3_k127_50772_2	443144.GM21_4000	1.319e-25	109.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42VAT@68525|delta/epsilon subdivisions,2WRE5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
CMS3_k127_50772_0	1125863.JAFN01000001_gene2410	1.481e-175	568.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
CMS3_k127_5103974_5	580327.Tthe_0193	1.453e-20	94.0	COG2088@1|root,COG2088@2|Bacteria,1V9ZG@1239|Firmicutes,24MVQ@186801|Clostridia,42GP6@68295|Thermoanaerobacterales	186801|Clostridia	D	Could be involved in septation	spoVG	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
CMS3_k127_5103974_2	237368.SCABRO_03965	2.712e-35	145.0	COG0705@1|root,COG0705@2|Bacteria,2J0D1@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS3_k127_5103974_7	311424.DhcVS_496	4.955e-05	49.0	2BPKF@1|root,32IDF@2|Bacteria,2GAWX@200795|Chloroflexi,34DI2@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	-	-	-	-	-	-	-	-	-	ATPase_gene1
CMS3_k127_5103974_1	1191523.MROS_0276	6.897e-60	215.0	COG0356@1|root,COG0356@2|Bacteria	2|Bacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
CMS3_k127_5103974_6	1268240.ATFI01000007_gene355	1.547e-18	87.0	COG0636@1|root,COG0636@2|Bacteria,4NURW@976|Bacteroidetes,2FTSZ@200643|Bacteroidia,4ARQC@815|Bacteroidaceae	976|Bacteroidetes	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
CMS3_k127_5103974_4	1191523.MROS_0274	1.035e-20	106.0	COG0711@1|root,COG0711@2|Bacteria	2|Bacteria	C	ATP synthesis coupled proton transport	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
CMS3_k127_5103974_3	1144275.COCOR_00379	9.614e-29	124.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,42U68@68525|delta/epsilon subdivisions,2WQJS@28221|Deltaproteobacteria,2YVS8@29|Myxococcales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
CMS3_k127_5103974_0	344747.PM8797T_28844	5.117e-109	357.0	COG0056@1|root,COG0056@2|Bacteria,2IXN5@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
CMS3_k127_5110391_2	1047013.AQSP01000003_gene2020	3.151e-92	308.0	COG0330@1|root,COG0330@2|Bacteria,2NP2X@2323|unclassified Bacteria	2|Bacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
CMS3_k127_5110391_1	1313304.CALK_1047	6.676e-142	472.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria	2|Bacteria	F	GMP synthase (glutamine-hydrolyzing) activity	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iJN746.PP_1032,iLJ478.TM1820,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833	GATase,GMP_synt_C,NAD_synthase
CMS3_k127_5110391_6	349521.HCH_07020	7.205e-27	116.0	2DCYH@1|root,32U0I@2|Bacteria,1NXZI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5110391_5	690850.Desaf_0047	1.884e-32	129.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2WRRT@28221|Deltaproteobacteria,2MCID@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS3_k127_5110391_4	1121013.P873_02380	6.924e-51	195.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,1RN0S@1236|Gammaproteobacteria,1X433@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
CMS3_k127_5110391_0	1121930.AQXG01000001_gene1203	3.91e-154	502.0	COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS3_k127_5122142_0	562970.Btus_1445	3.689e-113	381.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,2786J@186823|Alicyclobacillaceae	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF_1	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS3_k127_5122142_1	1378168.N510_01776	4.554e-37	151.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes	1239|Firmicutes	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_5122142_4	1268635.Loa_00422	2.373e-09	67.0	COG0236@1|root,COG0236@2|Bacteria,1NM9E@1224|Proteobacteria,1SINP@1236|Gammaproteobacteria,1JEJN@118969|Legionellales	118969|Legionellales	IQ	Phosphopantetheine attachment site	acpP_2	-	-	-	-	-	-	-	-	-	-	-	PP-binding
CMS3_k127_5122142_3	517418.Ctha_2098	7.297e-35	144.0	COG1028@1|root,COG1028@2|Bacteria,1FEYT@1090|Chlorobi	1090|Chlorobi	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS3_k127_5122142_2	927658.AJUM01000034_gene567	6.066e-36	155.0	29X8I@1|root,30IXV@2|Bacteria,4P0MB@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5123638_0	1278073.MYSTI_06440	4.074e-233	739.0	COG0339@1|root,COG0339@2|Bacteria,1R4AJ@1224|Proteobacteria,43BI1@68525|delta/epsilon subdivisions,2WMHM@28221|Deltaproteobacteria,2YUF2@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase family M3	prlC1	-	3.4.24.15	ko:K01392	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
CMS3_k127_5124448_3	95619.PM1_0222090	5.347e-09	66.0	COG2188@1|root,COG2188@2|Bacteria,1QVF7@1224|Proteobacteria,1S5D3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Putative porin	-	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Porin_5
CMS3_k127_5124448_0	859657.RPSI07_mp0608	9.178e-85	291.0	COG0697@1|root,COG0697@2|Bacteria,1MXJ6@1224|Proteobacteria,2VIA7@28216|Betaproteobacteria,1K5U4@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_5124448_2	1173020.Cha6605_1992	7.082e-54	207.0	COG0546@1|root,COG0546@2|Bacteria,1G6EE@1117|Cyanobacteria	1117|Cyanobacteria	S	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
CMS3_k127_5124448_1	1267534.KB906760_gene1549	6.77e-73	252.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y6A7@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
CMS3_k127_5134577_0	1452718.JBOY01000024_gene350	0.0	1157.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS3_k127_5142418_0	926550.CLDAP_00650	2.326e-224	711.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2G5NF@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	xdh	-	-	ko:K12528	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
CMS3_k127_5142418_1	1150474.JQJI01000029_gene902	2.986e-36	143.0	COG1529@1|root,COG1529@2|Bacteria,2GCJ6@200918|Thermotogae	200918|Thermotogae	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS3_k127_5142418_2	76114.ebA3604	9.584e-08	54.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ75@28216|Betaproteobacteria,2KW1Q@206389|Rhodocyclales	206389|Rhodocyclales	C	[2Fe-2S] binding domain	hcrC	-	1.3.7.9	ko:K04107	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	Fer2,Fer2_2
CMS3_k127_5164940_1	472759.Nhal_2060	1.809e-78	271.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RY8P@1236|Gammaproteobacteria,1WWGX@135613|Chromatiales	135613|Chromatiales	E	PFAM amino acid permease-associated region	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
CMS3_k127_5164940_0	1265313.HRUBRA_01379	1.082e-79	286.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1J4WP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
CMS3_k127_5164940_3	1122194.AUHU01000003_gene2427	8.413e-06	53.0	COG0500@1|root,COG2226@2|Bacteria,1N2R0@1224|Proteobacteria,1S422@1236|Gammaproteobacteria,46ASK@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS3_k127_5164940_4	1206743.BAGM01000207_gene175	0.0002689	46.0	COG1672@1|root,COG1672@2|Bacteria,2I39W@201174|Actinobacteria,4FZBA@85025|Nocardiaceae	201174|Actinobacteria	S	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,HTH_31,TIR_2,Trans_reg_C,Trypsin_2
CMS3_k127_5164940_2	880073.Calab_1488	1.178e-50	186.0	COG1600@1|root,COG1600@2|Bacteria,2NNWV@2323|unclassified Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
CMS3_k127_5167792_2	1191523.MROS_2406	7.711e-63	224.0	COG0686@1|root,COG0686@2|Bacteria	2|Bacteria	E	alanine dehydrogenase activity	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
CMS3_k127_5167792_0	1111069.TCCBUS3UF1_4090	1.398e-175	572.0	COG0427@1|root,COG0427@2|Bacteria,1WJIT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Acetyl-CoA hydrolase/transferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
CMS3_k127_5167792_1	1499967.BAYZ01000177_gene5733	6.142e-153	491.0	COG0677@1|root,COG0677@2|Bacteria,2NNV9@2323|unclassified Bacteria	2|Bacteria	M	UDP binding domain	-	-	1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520	-	R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS3_k127_5173142_1	388413.ALPR1_16858	3.373e-91	308.0	COG0500@1|root,COG2226@2|Bacteria,4NIN6@976|Bacteroidetes,47JAJ@768503|Cytophagia	976|Bacteroidetes	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Ubie_methyltran
CMS3_k127_5173142_2	234267.Acid_5194	3.232e-52	195.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
CMS3_k127_5173142_0	1379698.RBG1_1C00001G0365	3.661e-100	336.0	COG0501@1|root,COG0501@2|Bacteria,2NP1V@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
CMS3_k127_5173142_3	1283300.ATXB01000001_gene593	1.382e-06	56.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1XE13@135618|Methylococcales	135618|Methylococcales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
CMS3_k127_5185310_0	404589.Anae109_1169	1.715e-214	684.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,42NAD@68525|delta/epsilon subdivisions,2WKEY@28221|Deltaproteobacteria,2Z1IJ@29|Myxococcales	28221|Deltaproteobacteria	E	PFAM peptidase M3A and M3B thimet oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
CMS3_k127_5185310_1	880073.Calab_3390	6.725e-196	616.0	COG1740@1|root,COG1740@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor	hyaA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0048037,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_76,iUTI89_1310.UTI89_C1040	NiFe_hyd_SSU_C,Oxidored_q6
CMS3_k127_5185310_2	880073.Calab_3389	1.118e-132	425.0	COG0374@1|root,COG0374@2|Bacteria	2|Bacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hyaB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016151,GO:0016491,GO:0022900,GO:0030288,GO:0030313,GO:0031975,GO:0032991,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0044569,GO:0045333,GO:0046872,GO:0046914,GO:0055114,GO:0071944,GO:1902494	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	iSbBS512_1146.SbBS512_E2342	NiFeSe_Hases
CMS3_k127_5207599_1	1121430.JMLG01000003_gene627	5.207e-78	272.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,260DT@186807|Peptococcaceae	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
CMS3_k127_5207599_3	68570.DC74_769	0.0008753	49.0	COG1366@1|root,COG1366@2|Bacteria,2IHX1@201174|Actinobacteria	201174|Actinobacteria	T	STAS domain	-	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS,STAS_2
CMS3_k127_5207599_2	1321814.HMPREF9089_00613	1.796e-22	102.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,25X03@186806|Eubacteriaceae	186801|Clostridia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
CMS3_k127_5207599_0	42256.RradSPS_2004	5.074e-117	390.0	COG4398@1|root,COG4398@2|Bacteria,2I3VH@201174|Actinobacteria,4CQGG@84995|Rubrobacteria	84995|Rubrobacteria	S	FIST_C	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
CMS3_k127_5265140_0	485915.Dret_0887	3.729e-62	239.0	COG2203@1|root,COG2204@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria,2MHBW@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HD,HD_5,Response_reg
CMS3_k127_5265140_1	309801.trd_0227	3.014e-22	99.0	COG2206@1|root,COG2206@2|Bacteria,2GAMR@200795|Chloroflexi,27XPB@189775|Thermomicrobia	189775|Thermomicrobia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5
CMS3_k127_5265844_2	330214.NIDE3508	6.125e-52	190.0	28N6F@1|root,2ZBBB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5265844_5	1224318.DT73_25230	2.101e-08	59.0	COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	arsenate reductase	arsC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
CMS3_k127_5265844_4	335543.Sfum_2417	1.192e-19	101.0	COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,42UW2@68525|delta/epsilon subdivisions,2WQFD@28221|Deltaproteobacteria,2MS52@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
CMS3_k127_5265844_3	335543.Sfum_2416	6.126e-46	179.0	COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,42RZ3@68525|delta/epsilon subdivisions,2WNF0@28221|Deltaproteobacteria,2MRII@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
CMS3_k127_5265844_1	335543.Sfum_2415	3.33e-95	317.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,2MQ9V@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
CMS3_k127_5265844_0	1089552.KI911559_gene1174	3.615e-99	336.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria,2JRCW@204441|Rhodospirillales	204441|Rhodospirillales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
CMS3_k127_5266888_1	7739.XP_002610855.1	1.226e-13	74.0	COG0693@1|root,KOG2764@2759|Eukaryota,3A1YC@33154|Opisthokonta,3BQJG@33208|Metazoa,3CY3Z@33213|Bilateria,482Y6@7711|Chordata	33208|Metazoa	V	guanine deglycation, methylglyoxal removal	PARK7	GO:0000003,GO:0000302,GO:0000785,GO:0001504,GO:0001505,GO:0001817,GO:0001819,GO:0001932,GO:0001933,GO:0001934,GO:0001963,GO:0002020,GO:0002082,GO:0002237,GO:0002673,GO:0002675,GO:0002682,GO:0002684,GO:0002790,GO:0002861,GO:0002863,GO:0002864,GO:0002866,GO:0003674,GO:0003676,GO:0003712,GO:0003713,GO:0003723,GO:0003729,GO:0003824,GO:0005102,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005759,GO:0005783,GO:0005829,GO:0006066,GO:0006081,GO:0006082,GO:0006089,GO:0006091,GO:0006119,GO:0006139,GO:0006140,GO:0006163,GO:0006259,GO:0006281,GO:0006355,GO:0006357,GO:0006464,GO:0006469,GO:0006508,GO:0006517,GO:0006518,GO:0006521,GO:0006575,GO:0006584,GO:0006725,GO:0006749,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0006950,GO:0006974,GO:0006979,GO:0006996,GO:0007005,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007267,GO:0007268,GO:0007276,GO:0007283,GO:0007565,GO:0007568,GO:0007610,GO:0007626,GO:0008047,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008233,GO:0008283,GO:0008344,GO:0009058,GO:0009100,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009306,GO:0009438,GO:0009441,GO:0009566,GO:0009605,GO:0009607,GO:0009617,GO:0009636,GO:0009712,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009896,GO:0009914,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010155,GO:0010273,GO:0010310,GO:0010466,GO:0010468,GO:0010469,GO:0010506,GO:0010508,GO:0010556,GO:0010557,GO:0010562,GO:0010563,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010638,GO:0010646,GO:0010647,GO:0010648,GO:0010817,GO:0010821,GO:0010822,GO:0010941,GO:0010942,GO:0010951,GO:0012505,GO:0014065,GO:0015031,GO:0015696,GO:0015833,GO:0015844,GO:0015850,GO:0015872,GO:0015893,GO:0015980,GO:0016020,GO:0016043,GO:0016053,GO:0016209,GO:0016310,GO:0016491,GO:0016530,GO:0016531,GO:0016532,GO:0016604,GO:0016605,GO:0016684,GO:0016787,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0018158,GO:0018171,GO:0018193,GO:0018195,GO:0018198,GO:0018205,GO:0018307,GO:0018323,GO:0018958,GO:0019219,GO:0019220,GO:0019222,GO:0019249,GO:0019538,GO:0019637,GO:0019693,GO:0019725,GO:0019752,GO:0019899,GO:0019900,GO:0019953,GO:0019955,GO:0022414,GO:0022898,GO:0022900,GO:0022904,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0023061,GO:0030072,GO:0030073,GO:0030091,GO:0030162,GO:0030234,GO:0030424,GO:0030534,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0031331,GO:0031333,GO:0031347,GO:0031349,GO:0031396,GO:0031397,GO:0031399,GO:0031400,GO:0031401,GO:0031647,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0031981,GO:0031982,GO:0032091,GO:0032092,GO:0032101,GO:0032103,GO:0032147,GO:0032148,GO:0032268,GO:0032269,GO:0032270,GO:0032386,GO:0032387,GO:0032409,GO:0032410,GO:0032411,GO:0032412,GO:0032413,GO:0032434,GO:0032435,GO:0032496,GO:0032501,GO:0032502,GO:0032504,GO:0032507,GO:0032677,GO:0032757,GO:0032768,GO:0032770,GO:0032787,GO:0032879,GO:0032880,GO:0032940,GO:0033036,GO:0033043,GO:0033135,GO:0033138,GO:0033143,GO:0033145,GO:0033157,GO:0033233,GO:0033234,GO:0033238,GO:0033240,GO:0033365,GO:0033500,GO:0033554,GO:0033673,GO:0033674,GO:0033860,GO:0033864,GO:0033993,GO:0034308,GO:0034309,GO:0034504,GO:0034599,GO:0034613,GO:0034614,GO:0034641,GO:0034762,GO:0034763,GO:0034764,GO:0034765,GO:0034766,GO:0034767,GO:0035257,GO:0035258,GO:0035556,GO:0035690,GO:0036211,GO:0036470,GO:0036471,GO:0036478,GO:0036524,GO:0036525,GO:0036526,GO:0036527,GO:0036528,GO:0036529,GO:0036530,GO:0036531,GO:0040008,GO:0042053,GO:0042069,GO:0042176,GO:0042177,GO:0042180,GO:0042221,GO:0042325,GO:0042326,GO:0042327,GO:0042391,GO:0042417,GO:0042493,GO:0042542,GO:0042592,GO:0042593,GO:0042743,GO:0042773,GO:0042775,GO:0042802,GO:0042803,GO:0042886,GO:0042981,GO:0042995,GO:0043005,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043085,GO:0043086,GO:0043154,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043230,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043269,GO:0043270,GO:0043271,GO:0043281,GO:0043388,GO:0043393,GO:0043412,GO:0043436,GO:0043457,GO:0043467,GO:0043496,GO:0043523,GO:0043524,GO:0043549,GO:0043603,GO:0043900,GO:0043902,GO:0044087,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044297,GO:0044388,GO:0044390,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044427,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0044703,GO:0044706,GO:0045121,GO:0045184,GO:0045185,GO:0045333,GO:0045340,GO:0045764,GO:0045859,GO:0045860,GO:0045861,GO:0045893,GO:0045915,GO:0045926,GO:0045935,GO:0045936,GO:0045937,GO:0045944,GO:0045964,GO:0045981,GO:0046034,GO:0046165,GO:0046295,GO:0046394,GO:0046483,GO:0046677,GO:0046688,GO:0046689,GO:0046822,GO:0046823,GO:0046825,GO:0046826,GO:0046872,GO:0046879,GO:0046903,GO:0046914,GO:0046983,GO:0048015,GO:0048017,GO:0048232,GO:0048471,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048609,GO:0048638,GO:0048640,GO:0048878,GO:0050681,GO:0050727,GO:0050729,GO:0050776,GO:0050778,GO:0050787,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050821,GO:0050896,GO:0051049,GO:0051050,GO:0051051,GO:0051090,GO:0051091,GO:0051093,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051186,GO:0051193,GO:0051223,GO:0051224,GO:0051234,GO:0051235,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0051254,GO:0051336,GO:0051338,GO:0051339,GO:0051340,GO:0051341,GO:0051346,GO:0051347,GO:0051348,GO:0051349,GO:0051352,GO:0051353,GO:0051427,GO:0051438,GO:0051444,GO:0051457,GO:0051583,GO:0051595,GO:0051641,GO:0051649,GO:0051651,GO:0051704,GO:0051707,GO:0051716,GO:0051881,GO:0051896,GO:0051897,GO:0051899,GO:0051920,GO:0051934,GO:0051937,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060081,GO:0060135,GO:0060249,GO:0060255,GO:0060341,GO:0060548,GO:0060765,GO:0061136,GO:0061687,GO:0061827,GO:0062012,GO:0062013,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070050,GO:0070062,GO:0070201,GO:0070301,GO:0070491,GO:0070727,GO:0070887,GO:0071216,GO:0071219,GO:0071222,GO:0071236,GO:0071310,GO:0071396,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072330,GO:0072521,GO:0072593,GO:0072595,GO:0080090,GO:0080134,GO:0080135,GO:0080154,GO:0090073,GO:0090085,GO:0090086,GO:0090087,GO:0090304,GO:0090317,GO:0090322,GO:0090493,GO:0090494,GO:0097110,GO:0097159,GO:0097164,GO:0097223,GO:0097237,GO:0097238,GO:0097458,GO:0097501,GO:0098589,GO:0098657,GO:0098754,GO:0098772,GO:0098805,GO:0098810,GO:0098857,GO:0098869,GO:0098916,GO:0099536,GO:0099537,GO:0099601,GO:0106044,GO:0106045,GO:0106046,GO:0110095,GO:0110096,GO:0120025,GO:0140041,GO:0140096,GO:0140104,GO:0140110,GO:1900180,GO:1900182,GO:1900407,GO:1900408,GO:1900409,GO:1900449,GO:1900450,GO:1900542,GO:1900544,GO:1901031,GO:1901032,GO:1901033,GO:1901135,GO:1901214,GO:1901215,GO:1901298,GO:1901299,GO:1901360,GO:1901363,GO:1901564,GO:1901576,GO:1901615,GO:1901617,GO:1901654,GO:1901655,GO:1901668,GO:1901671,GO:1901700,GO:1901701,GO:1901799,GO:1901857,GO:1901983,GO:1901984,GO:1902041,GO:1902042,GO:1902175,GO:1902176,GO:1902177,GO:1902235,GO:1902236,GO:1902531,GO:1902532,GO:1902533,GO:1902680,GO:1902882,GO:1902883,GO:1902884,GO:1902903,GO:1902956,GO:1902958,GO:1903050,GO:1903051,GO:1903072,GO:1903073,GO:1903093,GO:1903094,GO:1903121,GO:1903122,GO:1903135,GO:1903136,GO:1903146,GO:1903167,GO:1903168,GO:1903176,GO:1903178,GO:1903179,GO:1903181,GO:1903189,GO:1903195,GO:1903197,GO:1903198,GO:1903200,GO:1903201,GO:1903202,GO:1903203,GO:1903204,GO:1903205,GO:1903206,GO:1903207,GO:1903208,GO:1903209,GO:1903320,GO:1903321,GO:1903362,GO:1903363,GO:1903376,GO:1903377,GO:1903383,GO:1903384,GO:1903426,GO:1903427,GO:1903428,GO:1903506,GO:1903508,GO:1903561,GO:1903573,GO:1903578,GO:1903580,GO:1903599,GO:1903750,GO:1903751,GO:1903827,GO:1903828,GO:1903829,GO:1903862,GO:1904062,GO:1904063,GO:1904064,GO:1904782,GO:1904833,GO:1904950,GO:1905258,GO:1905259,GO:1905446,GO:1905448,GO:1905516,GO:1905897,GO:1990169,GO:1990381,GO:1990748,GO:2000058,GO:2000059,GO:2000112,GO:2000116,GO:2000117,GO:2000121,GO:2000152,GO:2000157,GO:2000241,GO:2000243,GO:2000272,GO:2000273,GO:2000275,GO:2000277,GO:2000282,GO:2000284,GO:2000310,GO:2000377,GO:2000378,GO:2000379,GO:2000677,GO:2000679,GO:2000823,GO:2000825,GO:2001023,GO:2001024,GO:2001038,GO:2001039,GO:2001141,GO:2001233,GO:2001234,GO:2001235,GO:2001236,GO:2001237,GO:2001242,GO:2001243,GO:2001244,GO:2001257,GO:2001258,GO:2001267,GO:2001268	3.5.1.124	ko:K05687	ko05012,map05012	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	DJ-1_PfpI
CMS3_k127_5266888_0	177437.HRM2_07790	1.142e-147	483.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42MAP@68525|delta/epsilon subdivisions,2WIYI@28221|Deltaproteobacteria,2MJA8@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sodium:sulfate symporter transmembrane region	sdcS	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
CMS3_k127_5269183_1	748280.NH8B_0069	5.23e-55	198.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VI60@28216|Betaproteobacteria,2KQM5@206351|Neisseriales	206351|Neisseriales	M	Psort location Periplasmic, score 9.44	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CMS3_k127_5269183_4	997346.HMPREF9374_2813	3.045e-07	59.0	COG3688@1|root,COG3688@2|Bacteria,1V9XR@1239|Firmicutes,4HFW4@91061|Bacilli,27C4F@186824|Thermoactinomycetaceae	91061|Bacilli	S	YacP-like NYN domain	yacP	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	NYN_YacP
CMS3_k127_5269183_0	264732.Moth_0704	6.479e-57	215.0	COG0235@1|root,COG0235@2|Bacteria,1TS5G@1239|Firmicutes,248NY@186801|Clostridia,42FQD@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Class II aldolase adducin	fucA	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
CMS3_k127_5269183_3	187303.BN69_2485	2.36e-19	99.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2TV3A@28211|Alphaproteobacteria,36Y5H@31993|Methylocystaceae	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS3_k127_5269183_2	485918.Cpin_3446	4.861e-46	171.0	COG0388@1|root,COG0388@2|Bacteria,4NEME@976|Bacteroidetes,1IV6M@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.53,3.5.1.6	ko:K01431,ko:K12251	ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100	M00046	R00905,R01152,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
CMS3_k127_5284720_0	404589.Anae109_0232	2.565e-53	208.0	2DDTE@1|root,2ZJ6F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5284720_2	1313301.AUGC01000012_gene1354	0.0002607	53.0	COG2172@1|root,COG2172@2|Bacteria,4NRAA@976|Bacteroidetes	976|Bacteroidetes	T	Pfam Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	rsbW	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
CMS3_k127_5284720_1	1121013.P873_04890	3.818e-51	194.0	COG3595@1|root,COG3595@2|Bacteria,1P19T@1224|Proteobacteria,1RRSR@1236|Gammaproteobacteria,1X62K@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS3_k127_5293977_0	1379698.RBG1_1C00001G1545	2.219e-169	556.0	COG0745@1|root,COG0745@2|Bacteria,2NNXK@2323|unclassified Bacteria	2|Bacteria	KT	PglZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PglZ,Response_reg
CMS3_k127_5293977_3	649764.HMPREF0762_01927	4.831e-26	112.0	COG0802@1|root,COG0802@2|Bacteria,2IKV2@201174|Actinobacteria,4CVWX@84998|Coriobacteriia	84998|Coriobacteriia	S	Hydrolase, P-loop family	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
CMS3_k127_5293977_4	1229204.AMYY01000014_gene2047	2.027e-16	92.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2TTM2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG1214 Inactive homolog of metal-dependent proteases	yeaZ	-	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CMS3_k127_5293977_2	1297742.A176_02689	2.637e-32	131.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,42V77@68525|delta/epsilon subdivisions,2WRQF@28221|Deltaproteobacteria,2YVTX@29|Myxococcales	28221|Deltaproteobacteria	K	FR47-like protein	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
CMS3_k127_5293977_1	1379698.RBG1_1C00001G1549	1.367e-92	315.0	COG0777@1|root,COG0777@2|Bacteria,2NP40@2323|unclassified Bacteria	2|Bacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.accD,iPC815.YPO2768,iUTI89_1310.UTI89_C2601	Carboxyl_trans
CMS3_k127_5293977_5	706587.Desti_5086	1.668e-05	51.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,42N08@68525|delta/epsilon subdivisions,2WIW9@28221|Deltaproteobacteria,2MQBB@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Mur ligase, middle domain	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2475	Mur_ligase_C,Mur_ligase_M
CMS3_k127_5303436_0	1254432.SCE1572_02795	3.133e-113	390.0	COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_5303436_1	1121943.KB899996_gene511	5.834e-109	369.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1XIJ5@135619|Oceanospirillales	135619|Oceanospirillales	O	ATPase with chaperone activity	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
CMS3_k127_5359515_2	883.DvMF_2252	3.595e-10	63.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42Q0K@68525|delta/epsilon subdivisions,2WJUW@28221|Deltaproteobacteria,2M8AC@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Belongs to the DEAD box helicase family	dedA	-	3.6.4.13	ko:K03732,ko:K05592	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
CMS3_k127_5359515_0	1121920.AUAU01000013_gene1721	6.974e-122	401.0	COG0667@1|root,COG0667@2|Bacteria,3Y3TE@57723|Acidobacteria	57723|Acidobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS3_k127_5359515_1	236814.IX39_05235	1.282e-101	346.0	COG3104@1|root,COG3104@2|Bacteria,4NGWH@976|Bacteroidetes,1HY6B@117743|Flavobacteriia,3ZNTZ@59732|Chryseobacterium	976|Bacteroidetes	E	Amino acid transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
CMS3_k127_5363023_2	459349.CLOAM0984	1.537e-21	109.0	COG1361@1|root,COG1361@2|Bacteria,2NS3P@2323|unclassified Bacteria	2|Bacteria	M	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FlgD_ig,Peptidase_C25,Peptidase_C25_C,Propeptide_C25
CMS3_k127_5363023_0	1128421.JAGA01000002_gene730	7.611e-74	255.0	COG0225@1|root,COG0225@2|Bacteria,2NPBE@2323|unclassified Bacteria	2|Bacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
CMS3_k127_5363023_3	1121374.KB891591_gene3506	3.352e-15	84.0	2EFI3@1|root,339AJ@2|Bacteria,1N96F@1224|Proteobacteria,1SE0P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4252
CMS3_k127_5363023_4	1121430.JMLG01000019_gene1643	0.0003668	51.0	COG5662@1|root,COG5662@2|Bacteria,1VKS6@1239|Firmicutes,24VD1@186801|Clostridia	186801|Clostridia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
CMS3_k127_5363023_1	1089550.ATTH01000001_gene2333	6.084e-36	142.0	COG1595@1|root,COG1595@2|Bacteria,4PF4G@976|Bacteroidetes,1FK4D@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_5366612_2	768671.ThimaDRAFT_0675	3.592e-07	53.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1WX35@135613|Chromatiales	135613|Chromatiales	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	-	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	hDGE_amylase
CMS3_k127_5366612_0	671143.DAMO_0748	3.01e-50	194.0	COG1071@1|root,COG1071@2|Bacteria,2NPBB@2323|unclassified Bacteria	2|Bacteria	C	Dehydrogenase E1 component	bfmBA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166,ko:K11381,ko:K21416	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
CMS3_k127_5366612_1	877420.ATVW01000019_gene5	4.153e-10	63.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,27INP@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
CMS3_k127_5381809_0	216594.MMAR_2821	0.0	1090.0	COG2224@1|root,COG2224@2|Bacteria,2I926@201174|Actinobacteria,232A9@1762|Mycobacteriaceae	201174|Actinobacteria	C	Isocitrate lyase	aceAb	GO:0003674,GO:0003824,GO:0004451,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046421,GO:0046487,GO:0071704,GO:0072350	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
CMS3_k127_5381809_1	926549.KI421517_gene3224	6.108e-210	658.0	COG2225@1|root,COG2225@2|Bacteria,4NF5H@976|Bacteroidetes,47JKU@768503|Cytophagia	976|Bacteroidetes	C	Malate synthase	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
CMS3_k127_5402778_0	1173263.Syn7502_02027	1.062e-78	268.0	COG1166@1|root,COG1166@2|Bacteria,1G1C4@1117|Cyanobacteria,1GYFT@1129|Synechococcus	1117|Cyanobacteria	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
CMS3_k127_5433624_1	552811.Dehly_0396	2.765e-20	93.0	COG1960@1|root,COG1960@2|Bacteria,2G5K3@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_5433624_0	323850.Shew_2104	1.558e-110	377.0	COG3104@1|root,COG3104@2|Bacteria,1R5E8@1224|Proteobacteria,1RQR0@1236|Gammaproteobacteria,2QA3H@267890|Shewanellaceae	1236|Gammaproteobacteria	E	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_5433624_2	1379270.AUXF01000002_gene1561	5.162e-12	72.0	COG0393@1|root,COG0393@2|Bacteria,1ZU21@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
CMS3_k127_5433755_3	523850.TON_1151	3.479e-17	93.0	COG0308@1|root,arCOG02969@2157|Archaea,2Y34R@28890|Euryarchaeota,24392@183968|Thermococci	183968|Thermococci	E	Peptidase M1 membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
CMS3_k127_5433755_2	243231.GSU1926	2.341e-19	95.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,42X7G@68525|delta/epsilon subdivisions,2WSX9@28221|Deltaproteobacteria,43VJC@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NnrU,PEMT
CMS3_k127_5433755_1	338969.Rfer_3495	2.897e-65	233.0	COG0431@1|root,COG0431@2|Bacteria,1RAFI@1224|Proteobacteria,2VKQS@28216|Betaproteobacteria,4AC8E@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM NADPH-dependent FMN reductase	-	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
CMS3_k127_5433755_0	502025.Hoch_6851	1.813e-113	377.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,42NNY@68525|delta/epsilon subdivisions,2X9B9@28221|Deltaproteobacteria,2YX2A@29|Myxococcales	28221|Deltaproteobacteria	P	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
CMS3_k127_5441059_0	1120797.KB908255_gene447	2.578e-165	527.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria,2337J@1762|Mycobacteriaceae	201174|Actinobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
CMS3_k127_5441059_3	69395.JQLZ01000001_gene2996	0.0004065	53.0	COG3420@1|root,COG3420@2|Bacteria,1R5YP@1224|Proteobacteria	1224|Proteobacteria	P	Periplasmic copper-binding protein (NosD)	quiC	-	4.2.1.118	ko:K09483	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R01627	RC00568	ko00000,ko00001,ko01000	-	-	-	Beta_helix,NosD
CMS3_k127_5441059_1	208439.AJAP_27270	9.53e-15	79.0	COG1249@1|root,COG1249@2|Bacteria,2I5DW@201174|Actinobacteria,4EDWA@85010|Pseudonocardiales	201174|Actinobacteria	C	Alkylmercury lyase	-	-	-	-	-	-	-	-	-	-	-	-	MerB
CMS3_k127_5441059_2	33178.CADATEAP00004055	1.827e-10	63.0	2AAWD@1|root,2SAUR@2759|Eukaryota,39YPR@33154|Opisthokonta,3NYJM@4751|Fungi,3R1JE@4890|Ascomycota,20P6X@147545|Eurotiomycetes	4751|Fungi	S	Alkylmercury lyase	-	-	-	-	-	-	-	-	-	-	-	-	MerB
CMS3_k127_5441524_0	760568.Desku_1196	4.782e-197	628.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,260CE@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
CMS3_k127_5441524_1	443143.GM18_2316	3.737e-88	305.0	COG0438@1|root,COG0438@2|Bacteria,1NA28@1224|Proteobacteria,42NZA@68525|delta/epsilon subdivisions,2WK1T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	DUF3524,Glycos_transf_1
CMS3_k127_5441524_2	1254432.SCE1572_19815	3.91e-48	183.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,2YZNI@29|Myxococcales	28221|Deltaproteobacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
CMS3_k127_5450079_0	502025.Hoch_5203	2.093e-154	513.0	COG2866@1|root,COG2866@2|Bacteria,1N9W9@1224|Proteobacteria,433QQ@68525|delta/epsilon subdivisions,2WY7P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS3_k127_5456679_0	326423.RBAM_038080	1.922e-55	204.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,4HAYM@91061|Bacilli,1ZBXG@1386|Bacillus	91061|Bacilli	D	COG1192 ATPases involved in chromosome partitioning	soj	GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS3_k127_5456679_4	1449080.JQMV01000003_gene248	3.369e-19	95.0	COG0791@1|root,COG1388@1|root,COG0791@2|Bacteria,COG1388@2|Bacteria,1WJI4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Cell wall-associated hydrolase (invasion-associated protein)	-	-	-	-	-	-	-	-	-	-	-	-	LysM,NLPC_P60
CMS3_k127_5456679_3	749222.Nitsa_0770	3.424e-31	133.0	COG1225@1|root,COG1225@2|Bacteria,1NZF4@1224|Proteobacteria,42ZRX@68525|delta/epsilon subdivisions,2YRRA@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5456679_2	1125863.JAFN01000001_gene527	1.104e-47	186.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,42N6U@68525|delta/epsilon subdivisions,2WQ3X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
CMS3_k127_5456679_1	429009.Adeg_0571	1.688e-49	184.0	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,42FQZ@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
CMS3_k127_5479769_2	1403819.BATR01000093_gene2905	2.909e-117	387.0	COG3239@1|root,COG3239@2|Bacteria,46SX7@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Fatty acid desaturase	desA	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
CMS3_k127_5479769_0	472759.Nhal_1703	7.77e-139	453.0	COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria	1224|Proteobacteria	C	radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS3_k127_5479769_1	761193.Runsl_5264	2.192e-137	444.0	COG0667@1|root,COG0667@2|Bacteria,4NEDK@976|Bacteroidetes,47KXI@768503|Cytophagia	976|Bacteroidetes	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS3_k127_5479769_3	926566.Terro_4363	1.454e-11	68.0	COG0258@1|root,COG0258@2|Bacteria,3Y2FG@57723|Acidobacteria,2JME1@204432|Acidobacteriia	204432|Acidobacteriia	L	Helix-hairpin-helix class 2 (Pol1 family) motifs	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
CMS3_k127_5504649_4	1242864.D187_002897	0.0001516	48.0	COG4733@1|root,COG4733@2|Bacteria,1N010@1224|Proteobacteria,42M7U@68525|delta/epsilon subdivisions,2WRUR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Fibronectin, type III domain	-	-	3.2.1.4	ko:K01179,ko:K06882	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	fn3
CMS3_k127_5504649_1	1379698.RBG1_1C00001G1143	1.73e-27	114.0	COG0776@1|root,COG0776@2|Bacteria,2NPU6@2323|unclassified Bacteria	2|Bacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup_1	-	-	ko:K03530,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS3_k127_5504649_0	234267.Acid_2445	8.792e-135	447.0	COG2234@1|root,COG2234@2|Bacteria,3Y3KE@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
CMS3_k127_5504649_2	1210884.HG799462_gene8487	2.3e-21	102.0	COG0517@1|root,COG0517@2|Bacteria,2J0FD@203682|Planctomycetes	203682|Planctomycetes	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS3_k127_5504649_3	1341151.ASZU01000003_gene2540	1.858e-06	51.0	COG0388@1|root,COG0388@2|Bacteria,1UHWF@1239|Firmicutes,4HEQ4@91061|Bacilli,27BEE@186824|Thermoactinomycetaceae	91061|Bacilli	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
CMS3_k127_5515845_0	861299.J421_3809	1.085e-189	614.0	COG0058@1|root,COG0058@2|Bacteria,1ZSZ3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
CMS3_k127_5515845_1	118173.KB235914_gene2616	4.224e-111	377.0	COG2304@1|root,COG2304@2|Bacteria,1GQAG@1117|Cyanobacteria,1H979@1150|Oscillatoriales	1117|Cyanobacteria	T	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
CMS3_k127_5520361_5	880073.Calab_1858	6.528e-16	93.0	COG1361@1|root,COG4447@1|root,COG4935@1|root,COG1361@2|Bacteria,COG4447@2|Bacteria,COG4935@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FlgD_ig,TM_helix
CMS3_k127_5520361_7	1379270.AUXF01000005_gene471	1.097e-13	76.0	COG2966@1|root,COG3610@1|root,COG2966@2|Bacteria,COG3610@2|Bacteria,1ZTIR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Threonine/Serine exporter, ThrE	-	-	-	-	-	-	-	-	-	-	-	-	ThrE
CMS3_k127_5520361_0	204669.Acid345_2614	2.422e-184	586.0	COG2256@1|root,COG2256@2|Bacteria,3Y3F7@57723|Acidobacteria,2JIAH@204432|Acidobacteriia	204432|Acidobacteriia	L	AAA ATPase	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
CMS3_k127_5520361_1	880073.Calab_0541	2.402e-43	163.0	COG1993@1|root,COG1993@2|Bacteria,2NPXF@2323|unclassified Bacteria	2|Bacteria	T	Uncharacterized ACR, COG1993	-	-	-	ko:K06199,ko:K09137	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CBS,DUF190
CMS3_k127_5520361_2	1232437.KL661988_gene214	1.627e-30	124.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,42V4I@68525|delta/epsilon subdivisions,2WRJJ@28221|Deltaproteobacteria,2MKW0@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
CMS3_k127_5520361_6	1502851.FG93_06079	5.108e-15	79.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,3K2N3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
CMS3_k127_5520361_4	1382356.JQMP01000001_gene991	7.257e-19	98.0	COG0823@1|root,COG0823@2|Bacteria,2G8Z9@200795|Chloroflexi,27XTF@189775|Thermomicrobia	189775|Thermomicrobia	U	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
CMS3_k127_5520361_3	290317.Cpha266_0120	1.988e-24	103.0	COG0243@1|root,COG0243@2|Bacteria,1FDP0@1090|Chlorobi	1090|Chlorobi	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS3_k127_5520927_1	1118054.CAGW01000051_gene1339	1.238e-19	103.0	COG0419@1|root,COG0419@2|Bacteria,1UI2P@1239|Firmicutes,4ITDN@91061|Bacilli,277DC@186822|Paenibacillaceae	91061|Bacilli	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23
CMS3_k127_5520927_0	1123376.AUIU01000004_gene1166	2.315e-131	428.0	COG1004@1|root,COG1004@2|Bacteria,3J0EJ@40117|Nitrospirae	40117|Nitrospirae	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS3_k127_5526409_0	1123322.KB904634_gene2252	1.462e-41	163.0	COG0604@1|root,COG0604@2|Bacteria,2GK40@201174|Actinobacteria	201174|Actinobacteria	C	NADPH quinone reductase	fadB5	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
CMS3_k127_5526409_2	1206729.BAFZ01000089_gene2489	0.0004888	47.0	COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria,4FV36@85025|Nocardiaceae	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
CMS3_k127_5526409_1	1316936.K678_07081	2.084e-23	102.0	COG3155@1|root,COG3155@2|Bacteria,1MW2K@1224|Proteobacteria,2U6J6@28211|Alphaproteobacteria,2JRI9@204441|Rhodospirillales	204441|Rhodospirillales	Q	biosynthesis protein	elbB	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
CMS3_k127_5540495_1	653733.Selin_0317	1.509e-68	256.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS3_k127_5540495_4	543632.JOJL01000020_gene529	3.956e-05	55.0	COG3568@1|root,COG3568@2|Bacteria,2GNF9@201174|Actinobacteria,4DG4M@85008|Micromonosporales	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS3_k127_5540495_2	986075.CathTA2_1857	5.056e-33	130.0	COG1225@1|root,COG1225@2|Bacteria,1V6MU@1239|Firmicutes,4HK8J@91061|Bacilli	91061|Bacilli	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_5540495_3	986075.CathTA2_1858	7.246e-12	67.0	COG1225@1|root,COG1225@2|Bacteria,1VGP9@1239|Firmicutes,4HQ3V@91061|Bacilli	91061|Bacilli	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS3_k127_5540495_0	1283300.ATXB01000001_gene1800	6.966e-166	531.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria,1XDMT@135618|Methylococcales	1236|Gammaproteobacteria	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_5548564_1	1298598.JCM21714_74	2.832e-17	91.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli,470HZ@74385|Gracilibacillus	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
CMS3_k127_5548564_0	1379698.RBG1_1C00001G1491	4.15e-47	183.0	COG1420@1|root,COG1420@2|Bacteria,2NPAK@2323|unclassified Bacteria	2|Bacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA,HrcA_DNA-bdg
CMS3_k127_5548564_2	1410631.JHWZ01000007_gene636	0.0003061	48.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,27I7P@186928|unclassified Lachnospiraceae	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS3_k127_5550388_3	700598.Niako_5548	0.0002138	50.0	2DBCF@1|root,2Z8DB@2|Bacteria,4NG6B@976|Bacteroidetes,1IQA3@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi
CMS3_k127_5550388_2	1461577.CCMH01000003_gene1085	4.871e-09	61.0	COG0268@1|root,COG0268@2|Bacteria,4NSB1@976|Bacteroidetes,1I3XI@117743|Flavobacteriia	976|Bacteroidetes	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
CMS3_k127_5550388_0	706587.Desti_5005	1.139e-197	640.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WKA2@28221|Deltaproteobacteria,2MQBJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
CMS3_k127_5550388_1	1191523.MROS_2577	1.312e-22	102.0	COG0308@1|root,COG0823@1|root,COG4775@1|root,COG0308@2|Bacteria,COG0823@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K03641,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,2.C.1.2	-	-	BSP,Bac_surface_Ag,CarbopepD_reg_2,NAAA-beta,PD40,Peptidase_M1,Phospholip_B
CMS3_k127_5562334_1	264732.Moth_1695	3.743e-71	251.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,42ETD@68295|Thermoanaerobacterales	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
CMS3_k127_5562334_0	880073.Calab_3729	1.537e-120	402.0	COG0343@1|root,COG0343@2|Bacteria,2NNQS@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
CMS3_k127_5562334_4	889378.Spiaf_0201	2.353e-15	81.0	COG1862@1|root,COG1862@2|Bacteria,2J8D6@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
CMS3_k127_5562334_2	518766.Rmar_0874	2.43e-48	181.0	COG0242@1|root,COG0242@2|Bacteria,4NFB4@976|Bacteroidetes,1FJAZ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
CMS3_k127_5562334_3	331869.BAL199_15002	4.222e-26	112.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2TSWX@28211|Alphaproteobacteria,4BP6B@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
CMS3_k127_5564258_0	880072.Desac_2474	2.449e-121	409.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,42M48@68525|delta/epsilon subdivisions,2WISV@28221|Deltaproteobacteria,2MQ63@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
CMS3_k127_5564258_1	861299.J421_3964	1.285e-63	229.0	COG5405@1|root,COG5405@2|Bacteria,1ZSVH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
CMS3_k127_5564258_2	269799.Gmet_3042	1.242e-34	136.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42Q4U@68525|delta/epsilon subdivisions,2WJ08@28221|Deltaproteobacteria,43U9P@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS3_k127_5575211_1	880073.Calab_3775	9.014e-76	263.0	COG0621@1|root,COG0621@2|Bacteria,2NP2U@2323|unclassified Bacteria	2|Bacteria	J	Uncharacterized protein family UPF0004	yqeV	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
CMS3_k127_5575211_0	502025.Hoch_3784	2.128e-144	483.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,1MV5G@1224|Proteobacteria,42MPT@68525|delta/epsilon subdivisions,2WJG9@28221|Deltaproteobacteria,2YUJ4@29|Myxococcales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
CMS3_k127_5580397_2	1205753.A989_01840	1.301e-44	169.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1X4A7@135614|Xanthomonadales	135614|Xanthomonadales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
CMS3_k127_5580397_4	1210884.HG799463_gene9988	5.116e-08	59.0	COG5343@1|root,COG5343@2|Bacteria	2|Bacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA,zf-HC2
CMS3_k127_5580397_1	391625.PPSIR1_34817	1.092e-47	180.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
CMS3_k127_5580397_3	1121405.dsmv_1897	1.109e-10	67.0	COG1225@1|root,COG1225@2|Bacteria,1NN23@1224|Proteobacteria,42XJF@68525|delta/epsilon subdivisions,2WTAE@28221|Deltaproteobacteria,2MNXB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	AhpC/TSA antioxidant enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA_2
CMS3_k127_5580397_0	521011.Mpal_0423	2.578e-73	260.0	COG3391@1|root,arCOG02516@1|root,arCOG02516@2157|Archaea,arCOG03563@2157|Archaea,2Y7Y4@28890|Euryarchaeota,2NBN4@224756|Methanomicrobia	2157|Archaea	S	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,HemolysinCabind,Kelch_4,NHL,PKD
CMS3_k127_5580397_5	1254432.SCE1572_24245	0.0001618	50.0	COG5012@1|root,COG5012@2|Bacteria,1RE0V@1224|Proteobacteria,42VZ0@68525|delta/epsilon subdivisions,2WRFJ@28221|Deltaproteobacteria,2YX04@29|Myxococcales	28221|Deltaproteobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
CMS3_k127_558178_0	1379698.RBG1_1C00001G0805	4.71e-180	575.0	COG1012@1|root,COG1012@2|Bacteria,2NNWB@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the aldehyde dehydrogenase family	aldH	-	1.2.1.3	ko:K00128,ko:K00138	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00711,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_558178_1	861299.J421_5582	2.549e-85	291.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	bamU	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
CMS3_k127_558178_2	869210.Marky_1692	1.02e-16	81.0	COG0604@1|root,COG0604@2|Bacteria,1WI1Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	COG0604 NADPH quinone reductase and related Zn-dependent	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_5650829_2	234267.Acid_4844	1.71e-34	139.0	COG1164@1|root,COG1164@2|Bacteria,3Y2SB@57723|Acidobacteria	57723|Acidobacteria	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
CMS3_k127_5650829_1	234267.Acid_3868	1.995e-43	169.0	COG0053@1|root,COG0053@2|Bacteria,3Y5VF@57723|Acidobacteria	57723|Acidobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
CMS3_k127_5650829_0	1185876.BN8_02139	1.504e-97	334.0	COG2866@1|root,COG2866@2|Bacteria,4NGIE@976|Bacteroidetes,47N2M@768503|Cytophagia	976|Bacteroidetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS3_k127_5669294_4	1380390.JIAT01000010_gene4359	1.4e-27	124.0	COG0125@1|root,COG0125@2|Bacteria,2H78H@201174|Actinobacteria	201174|Actinobacteria	F	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5669294_1	765913.ThidrDRAFT_4503	1.487e-74	267.0	COG0394@1|root,COG1073@1|root,COG3919@1|root,COG0394@2|Bacteria,COG1073@2|Bacteria,COG3919@2|Bacteria,1R61B@1224|Proteobacteria,1S0E7@1236|Gammaproteobacteria,1WYBD@135613|Chromatiales	135613|Chromatiales	T	TIGRFAM Hydrolase, ortholog 1, exosortase system type 1 associated	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
CMS3_k127_5669294_3	272562.CA_C3056	3.535e-47	182.0	COG1208@1|root,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,36UK6@31979|Clostridiaceae	186801|Clostridia	GJM	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	gmhB	-	2.7.7.13,2.7.7.71,3.1.3.82,3.1.3.83,5.4.2.8	ko:K00966,ko:K03273,ko:K15669,ko:K16881	ko00051,ko00520,ko00540,ko01100,ko01110,ko01130,map00051,map00520,map00540,map01100,map01110,map01130	M00064,M00114,M00361,M00362	R00885,R01818,R05647,R09771,R09772	RC00002,RC00017,RC00408	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hydrolase_like,NTP_transferase,PNK3P
CMS3_k127_5669294_0	592015.HMPREF1705_00545	3.867e-122	402.0	COG2605@1|root,COG2605@2|Bacteria,3TC8T@508458|Synergistetes	508458|Synergistetes	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
CMS3_k127_5669294_2	383372.Rcas_3096	2.644e-50	188.0	COG0279@1|root,COG0279@2|Bacteria,2G6QD@200795|Chloroflexi,375VE@32061|Chloroflexia	32061|Chloroflexia	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
CMS3_k127_5679106_2	945713.IALB_1339	2.512e-77	263.0	COG0302@1|root,COG0302@2|Bacteria	2|Bacteria	H	gtp cyclohydrolase	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
CMS3_k127_5679106_0	1121405.dsmv_0201	2.961e-80	278.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,42NS5@68525|delta/epsilon subdivisions,2WNQ5@28221|Deltaproteobacteria,2MJ7B@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
CMS3_k127_5679106_3	1121904.ARBP01000001_gene5713	2.367e-37	148.0	2E1HF@1|root,32WVJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3996
CMS3_k127_5679106_1	237368.SCABRO_02564	6.393e-80	286.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,2IZEZ@203682|Planctomycetes	203682|Planctomycetes	S	Memo-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1,Memo
CMS3_k127_5683157_1	452637.Oter_0373	7.079e-134	430.0	COG1509@1|root,COG1509@2|Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	kamA3	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
CMS3_k127_5683157_0	1304888.ATWF01000001_gene788	2.17e-184	588.0	COG0436@1|root,COG0436@2|Bacteria,2GENK@200930|Deferribacteres	200930|Deferribacteres	E	Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_5683157_2	440512.C211_11437	1.18e-33	141.0	COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,1RNBI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_5703267_0	290397.Adeh_1613	3.514e-220	699.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA1	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
CMS3_k127_5703267_7	1254432.SCE1572_51465	1.045e-33	135.0	COG0838@1|root,COG0838@2|Bacteria,1PPP3@1224|Proteobacteria,42VF4@68525|delta/epsilon subdivisions,2WRIV@28221|Deltaproteobacteria,2Z22Z@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
CMS3_k127_5703267_4	404589.Anae109_1288	9.013e-69	244.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2WNNV@28221|Deltaproteobacteria,2Z08H@29|Myxococcales	28221|Deltaproteobacteria	C	Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
CMS3_k127_5703267_5	880073.Calab_2691	1.389e-47	175.0	COG0852@1|root,COG0852@2|Bacteria,2NPN6@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
CMS3_k127_5703267_2	1254432.SCE1572_51480	4.139e-144	469.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2YWJS@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
CMS3_k127_5703267_3	1254432.SCE1572_43755	4.951e-122	404.0	COG0265@1|root,COG1005@1|root,COG0265@2|Bacteria,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2YYND@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh,PDZ_2
CMS3_k127_5703267_6	1254432.SCE1572_46100	1.674e-42	165.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42SZV@68525|delta/epsilon subdivisions,2WP8T@28221|Deltaproteobacteria,2Z0UI@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338,ko:K05580	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_4,Fer4_7
CMS3_k127_5703267_8	331678.Cphamn1_1601	1.908e-33	136.0	COG0839@1|root,COG0839@2|Bacteria,1FDZK@1090|Chlorobi	1090|Chlorobi	C	PFAM NADH-ubiquinone plastoquinone oxidoreductase, chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
CMS3_k127_5703267_9	1254432.SCE1572_46090	1.162e-22	102.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42WIQ@68525|delta/epsilon subdivisions,2WS3A@28221|Deltaproteobacteria,2Z1V8@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
CMS3_k127_5703267_1	700598.Niako_7073	2.399e-183	597.0	COG1009@1|root,COG1009@2|Bacteria,4NEBM@976|Bacteroidetes,1IQ9D@117747|Sphingobacteriia	976|Bacteroidetes	CP	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
CMS3_k127_5708584_7	1514668.JOOA01000002_gene2286	8.08e-09	63.0	COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia,3WIMH@541000|Ruminococcaceae	186801|Clostridia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
CMS3_k127_5708584_2	586413.CCDL010000002_gene2492	5.653e-71	255.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,23IWX@182709|Oceanobacillus	91061|Bacilli	J	tRNA (Guanine-1)-methyltransferase	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
CMS3_k127_5708584_5	1304880.JAGB01000001_gene45	4.436e-39	149.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia	186801|Clostridia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
CMS3_k127_5708584_4	1125863.JAFN01000001_gene2290	6.622e-48	181.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,42REG@68525|delta/epsilon subdivisions,2WNK2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DUF208,RNase_HII
CMS3_k127_5708584_8	446466.Cfla_1478	2.272e-08	64.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4F2QP@85016|Cellulomonadaceae	201174|Actinobacteria	L	Belongs to the UPF0102 family	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
CMS3_k127_5708584_9	404380.Gbem_0247	0.0003462	48.0	COG2952@1|root,COG2952@2|Bacteria,1NKWU@1224|Proteobacteria,42XJT@68525|delta/epsilon subdivisions,2WSNN@28221|Deltaproteobacteria,43SST@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF507)	-	-	-	-	-	-	-	-	-	-	-	-	DUF507
CMS3_k127_5708584_1	768710.DesyoDRAFT_4626	3.952e-107	357.0	COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,260DU@186807|Peptococcaceae	186801|Clostridia	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
CMS3_k127_5708584_3	357808.RoseRS_3316	2.726e-59	227.0	COG0483@1|root,COG0483@2|Bacteria,2G6JD@200795|Chloroflexi,375ER@32061|Chloroflexia	32061|Chloroflexia	G	PFAM inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
CMS3_k127_5708584_6	1379698.RBG1_1C00001G0461	3.021e-28	121.0	COG2143@1|root,COG2143@2|Bacteria	2|Bacteria	O	COG2143 Thioredoxin-related protein	-	-	-	-	-	-	-	-	-	-	-	-	Thioredox_DsbH,Thioredoxin_2,Thioredoxin_7
CMS3_k127_5708584_0	706587.Desti_5519	3.153e-126	412.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2WIT7@28221|Deltaproteobacteria,2MQ90@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_3528	Seryl_tRNA_N,tRNA-synt_2b
CMS3_k127_5717304_0	1265505.ATUG01000001_gene3440	2.755e-25	121.0	COG5000@1|root,COG5000@2|Bacteria,1R9K1@1224|Proteobacteria,42NHR@68525|delta/epsilon subdivisions,2WJUQ@28221|Deltaproteobacteria,2MMGT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Cache 3/Cache 2 fusion domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,dCache_1
CMS3_k127_5717304_1	1123274.KB899419_gene1882	1.327e-15	79.0	COG1551@1|root,COG1551@2|Bacteria,2J8VE@203691|Spirochaetes	203691|Spirochaetes	J	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
CMS3_k127_5717304_2	443144.GM21_3832	2.683e-08	66.0	COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria	1224|Proteobacteria	Q	Tpr repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_17,TPR_19,TPR_2,TPR_8
CMS3_k127_5720776_1	321332.CYB_2318	2.949e-42	167.0	COG1011@1|root,COG1011@2|Bacteria,1G51I@1117|Cyanobacteria,1H0H2@1129|Synechococcus	1117|Cyanobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
CMS3_k127_5720776_0	485913.Krac_9382	1.222e-140	456.0	COG1505@1|root,COG1505@2|Bacteria,2GBNH@200795|Chloroflexi	200795|Chloroflexi	E	Peptidase S9, prolyl oligopeptidase active site domain protein	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
CMS3_k127_5727024_2	452637.Oter_1700	6.576e-57	206.0	COG2197@1|root,COG2197@2|Bacteria,46UGC@74201|Verrucomicrobia,3K7ZK@414999|Opitutae	74201|Verrucomicrobia	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_5727024_0	452637.Oter_2821	1.545e-153	507.0	COG0755@1|root,COG0755@2|Bacteria,46SIH@74201|Verrucomicrobia,3K7UF@414999|Opitutae	414999|Opitutae	O	PFAM cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
CMS3_k127_5727024_1	452637.Oter_2587	1.275e-93	321.0	COG1333@1|root,COG1333@2|Bacteria,46SUY@74201|Verrucomicrobia,3K75U@414999|Opitutae	414999|Opitutae	O	ResB-like family	-	-	-	-	-	-	-	-	-	-	-	-	ResB
CMS3_k127_5727024_3	452637.Oter_2586	2.118e-38	158.0	2E533@1|root,32ZW9@2|Bacteria,46SZX@74201|Verrucomicrobia,3K856@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5727024_4	1298867.AUES01000016_gene3879	3.276e-07	59.0	COG2203@1|root,COG4191@1|root,COG5002@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3K6MV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,dCache_1
CMS3_k127_5741214_1	945713.IALB_2429	6.507e-74	261.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02481,ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_5741214_0	204669.Acid345_2603	4.218e-119	404.0	COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria,2JP3M@204432|Acidobacteriia	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_5741214_2	1232437.KL662008_gene3441	7.126e-13	79.0	COG0509@1|root,COG0509@2|Bacteria,1RC80@1224|Proteobacteria,42R79@68525|delta/epsilon subdivisions,2WN04@28221|Deltaproteobacteria,2MJJZ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	GCV_H
CMS3_k127_575185_2	316067.Geob_0737	5.565e-08	55.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS3_k127_575185_0	644282.Deba_2069	1.03e-26	113.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2WRRT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS3_k127_575185_3	1340493.JNIF01000003_gene4784	0.00011	53.0	COG0515@1|root,COG0515@2|Bacteria	1340493.JNIF01000003_gene4784|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_577782_1	448385.sce0197	6.719e-120	401.0	COG3857@1|root,COG3857@2|Bacteria	2|Bacteria	L	exonuclease activity	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
CMS3_k127_577782_0	84531.JMTZ01000023_gene4233	3.929e-221	728.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1X499@135614|Xanthomonadales	1236|Gammaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small
CMS3_k127_577782_3	1303692.SFUL_7019	4.795e-06	54.0	COG1366@1|root,COG1366@2|Bacteria,2IR28@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS_2
CMS3_k127_577782_2	479434.Sthe_2092	1.051e-11	67.0	COG1074@1|root,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	-	-	3.1.11.5,3.1.12.1,3.6.4.12	ko:K01144,ko:K07464,ko:K16898	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
CMS3_k127_5785634_1	575540.Isop_2111	2.263e-79	275.0	COG1131@1|root,COG1131@2|Bacteria,2IZ5V@203682|Planctomycetes	203682|Planctomycetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_5785634_0	1047013.AQSP01000128_gene414	1.848e-80	279.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	nosF	-	-	ko:K01990,ko:K19340	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC_tran
CMS3_k127_578963_3	1461580.CCAS010000087_gene4362	1.517e-07	58.0	COG4448@1|root,COG4448@2|Bacteria,1TRWI@1239|Firmicutes,4HAM1@91061|Bacilli,1ZEJW@1386|Bacillus	91061|Bacilli	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
CMS3_k127_578963_0	1313301.AUGC01000003_gene2146	2.706e-175	562.0	COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes	976|Bacteroidetes	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.32,1.2.1.85	ko:K10217	ko00362,ko00380,ko00622,ko01100,ko01120,ko01220,map00362,map00380,map00622,map01100,map01120,map01220	M00038,M00569	R02762,R03889,R05353	RC00218,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS3_k127_578963_1	762376.AXYL_02641	2.803e-113	386.0	COG3384@1|root,COG3384@2|Bacteria,1PUF4@1224|Proteobacteria,2VZW8@28216|Betaproteobacteria,3T6P8@506|Alcaligenaceae	28216|Betaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	1.13.11.74,1.13.11.76	ko:K15059	ko00627,ko01120,map00627,map01120	-	R05405	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
CMS3_k127_578963_2	263358.VAB18032_17820	1.637e-39	166.0	COG3384@1|root,COG3384@2|Bacteria,2H395@201174|Actinobacteria	201174|Actinobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15058	ko00627,ko01120,map00627,map01120	-	R05405	RC00387	ko00000,ko00001	-	-	-	LigB
CMS3_k127_5814171_0	1163617.SCD_n02152	2.22e-81	281.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2VQVG@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase type 11	arsM	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
CMS3_k127_5814171_3	309799.DICTH_0595	8.583e-17	81.0	COG3634@1|root,COG3634@2|Bacteria	2|Bacteria	C	alkyl hydroperoxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
CMS3_k127_5814171_1	880073.Calab_1228	5.452e-50	183.0	COG3634@1|root,COG3634@2|Bacteria,2NPR2@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
CMS3_k127_5814171_2	861299.J421_5989	7.112e-22	97.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
CMS3_k127_584661_1	1304885.AUEY01000006_gene719	4.184e-60	227.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2WJ7A@28221|Deltaproteobacteria,2MIEV@213118|Desulfobacterales	28221|Deltaproteobacteria	M	SMART PDZ DHR GLGF domain protein	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
CMS3_k127_584661_0	370438.PTH_1260	1.744e-112	376.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,2483M@186801|Clostridia,260S5@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06420	DXPR_C,DXP_redisom_C,DXP_reductoisom
CMS3_k127_584661_2	945713.IALB_0622	3.211e-35	141.0	COG4589@1|root,COG4589@2|Bacteria	2|Bacteria	S	phosphatidate cytidylyltransferase activity	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
CMS3_k127_587065_2	767434.Fraau_2520	8.75e-28	115.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1X3TR@135614|Xanthomonadales	135614|Xanthomonadales	J	Specifically methylates the ribose of guanosine 2251 in 23S rRNA	rlmB	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
CMS3_k127_587065_3	644282.Deba_2952	7.407e-15	76.0	COG0267@1|root,COG0267@2|Bacteria,1NJ67@1224|Proteobacteria,42V5X@68525|delta/epsilon subdivisions,2WSIR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
CMS3_k127_587065_4	880072.Desac_1469	7.981e-12	68.0	COG0690@1|root,COG0690@2|Bacteria,1Q1BI@1224|Proteobacteria,42X4Z@68525|delta/epsilon subdivisions,2WSQ8@28221|Deltaproteobacteria,2MSHF@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
CMS3_k127_587065_0	404589.Anae109_2226	5.959e-77	264.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,42MPQ@68525|delta/epsilon subdivisions,2WMP6@28221|Deltaproteobacteria,2YV7X@29|Myxococcales	28221|Deltaproteobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
CMS3_k127_587065_1	338963.Pcar_0690	3.572e-61	213.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,42RE7@68525|delta/epsilon subdivisions,2WNAH@28221|Deltaproteobacteria,43UY3@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein L11/L12	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
CMS3_k127_5874417_1	1437425.CSEC_1981	6.494e-93	312.0	COG1158@1|root,COG1158@2|Bacteria,2JFQF@204428|Chlamydiae	204428|Chlamydiae	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
CMS3_k127_5874417_0	1300345.LF41_1045	4.477e-169	544.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,1RQRJ@1236|Gammaproteobacteria,1X83S@135614|Xanthomonadales	135614|Xanthomonadales	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
CMS3_k127_5874417_2	886293.Sinac_2960	7.565e-35	140.0	COG0463@1|root,COG0463@2|Bacteria,2J550@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_5876722_0	886293.Sinac_3294	1.58e-84	288.0	COG0399@1|root,COG0399@2|Bacteria,2IXRE@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS3_k127_5876722_1	316067.Geob_3309	7.91e-28	132.0	COG1657@1|root,COG4932@1|root,COG1657@2|Bacteria,COG4932@2|Bacteria,1PF83@1224|Proteobacteria,430QE@68525|delta/epsilon subdivisions	1224|Proteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
CMS3_k127_5876722_2	1123278.KB893570_gene2430	5.915e-07	63.0	COG3291@1|root,COG4447@1|root,COG3291@2|Bacteria,COG4447@2|Bacteria,4NGJJ@976|Bacteroidetes,47KNC@768503|Cytophagia	976|Bacteroidetes	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5879473_0	880073.Calab_3241	2.187e-160	518.0	COG0439@1|root,COG0439@2|Bacteria,2NNWM@2323|unclassified Bacteria	2|Bacteria	I	acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
CMS3_k127_5879473_1	391625.PPSIR1_32173	2.618e-63	242.0	COG4799@1|root,COG4799@2|Bacteria,1QXDB@1224|Proteobacteria	1224|Proteobacteria	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
CMS3_k127_5891821_0	868595.Desca_0098	1.59e-194	638.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,2600Y@186807|Peptococcaceae	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
CMS3_k127_5892224_2	1304874.JAFY01000002_gene864	1.592e-15	79.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	thiJ	-	2.7.11.1,3.5.1.124	ko:K03152,ko:K05520,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko01002	-	-	-	DJ-1_PfpI
CMS3_k127_5892224_3	886379.AEWI01000013_gene2117	9.089e-11	74.0	2D6WA@1|root,32TMZ@2|Bacteria,4NU16@976|Bacteroidetes,2FYYU@200643|Bacteroidia,3XKM2@558415|Marinilabiliaceae	976|Bacteroidetes	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
CMS3_k127_5892224_0	518766.Rmar_1768	3.862e-122	410.0	COG3225@1|root,COG3225@2|Bacteria,4NF62@976|Bacteroidetes,1FJTM@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
CMS3_k127_5892224_1	518766.Rmar_1769	5.906e-62	221.0	COG1277@1|root,COG1277@2|Bacteria,4NG5G@976|Bacteroidetes,1FK62@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
CMS3_k127_5910659_9	159450.NH14_03140	0.0001812	44.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,1K01W@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS3_k127_5910659_1	1232410.KI421415_gene3092	2.388e-103	354.0	COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,42NBG@68525|delta/epsilon subdivisions,2WKMN@28221|Deltaproteobacteria,43SUB@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemY	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
CMS3_k127_5910659_2	485916.Dtox_1611	7.839e-100	344.0	COG0535@1|root,COG0535@2|Bacteria,1URM8@1239|Firmicutes,24XB8@186801|Clostridia	186801|Clostridia	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS3_k127_5910659_0	330214.NIDE2194	4.941e-113	377.0	COG1533@1|root,COG1533@2|Bacteria,3J0QV@40117|Nitrospirae	40117|Nitrospirae	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS3_k127_5910659_5	861299.J421_0735	5.488e-40	159.0	COG0457@1|root,COG0457@2|Bacteria	861299.J421_0735|-	S	peptidyl-tyrosine sulfation	-	-	-	ko:K13992	-	-	-	-	ko00000,ko00194	-	-	-	-
CMS3_k127_5910659_6	1304885.AUEY01000095_gene2623	2.507e-36	144.0	COG2010@1|root,COG2010@2|Bacteria,1NKKK@1224|Proteobacteria,42UAC@68525|delta/epsilon subdivisions,2WXVI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
CMS3_k127_5910659_3	631454.N177_4027	3.816e-53	196.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2TU68@28211|Alphaproteobacteria,1JNSI@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
CMS3_k127_5910659_7	1379698.RBG1_1C00001G1317	1.365e-16	91.0	COG1361@1|root,COG3391@1|root,COG1361@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
CMS3_k127_5910659_4	395495.Lcho_3084	7.8e-47	184.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VIBU@28216|Betaproteobacteria,1KMCE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_5935116_0	1034943.BN1094_02167	2.969e-74	269.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1JDPB@118969|Legionellales	118969|Legionellales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
CMS3_k127_5935116_2	1408445.JHXP01000009_gene2837	1.121e-49	187.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,1SVID@1236|Gammaproteobacteria,1JD85@118969|Legionellales	118969|Legionellales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
CMS3_k127_5935116_1	1267535.KB906767_gene3785	1.632e-51	192.0	COG0034@1|root,COG0034@2|Bacteria,3Y3RG@57723|Acidobacteria,2JHXM@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
CMS3_k127_5938389_0	879212.DespoDRAFT_00867	1.95e-65	238.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MIP0@213118|Desulfobacterales	68525|delta/epsilon subdivisions	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
CMS3_k127_5938389_1	768671.ThimaDRAFT_1377	3.043e-42	162.0	2CUA5@1|root,32SUX@2|Bacteria,1RJP0@1224|Proteobacteria,1S7U4@1236|Gammaproteobacteria,1X2QJ@135613|Chromatiales	135613|Chromatiales	C	NADH ubiquinone oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CIA30
CMS3_k127_5938389_2	1123242.JH636434_gene5238	6.189e-10	69.0	2E55N@1|root,32ZYI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5940798_0	1111069.TCCBUS3UF1_4370	6.768e-99	335.0	COG1404@1|root,COG1404@2|Bacteria,1WIDU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	3.4.21.111	ko:K20754	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Inhibitor_I9,Peptidase_S8
CMS3_k127_5940798_1	395493.BegalDRAFT_3451	0.0006689	46.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,460F4@72273|Thiotrichales	72273|Thiotrichales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
CMS3_k127_595277_2	880073.Calab_2216	8.852e-11	65.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	ebh	-	-	-	-	-	-	-	-	-	-	-	DUF1611,Inhibitor_I9,Peptidase_S8,SLH
CMS3_k127_595277_0	880073.Calab_1556	3.511e-52	197.0	COG2067@1|root,COG2067@2|Bacteria,2NR34@2323|unclassified Bacteria	2|Bacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_595277_1	234267.Acid_0899	3.28e-13	83.0	COG4219@1|root,COG4219@2|Bacteria,3Y4QS@57723|Acidobacteria	2|Bacteria	KT	Peptidase M56, BlaR1	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56,TonB_C
CMS3_k127_595277_3	251221.35212970	2.547e-05	53.0	COG0811@1|root,COG0811@2|Bacteria,1G1RE@1117|Cyanobacteria	1117|Cyanobacteria	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
CMS3_k127_595548_0	344747.PM8797T_24386	2.336e-135	449.0	COG1473@1|root,COG1473@2|Bacteria,2IX7P@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_595548_2	1242864.D187_005264	3.277e-12	80.0	COG2382@1|root,COG2382@2|Bacteria,1R2QZ@1224|Proteobacteria,43DG9@68525|delta/epsilon subdivisions,2X8N7@28221|Deltaproteobacteria,2Z3N0@29|Myxococcales	28221|Deltaproteobacteria	P	Starch binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CBM_20,Esterase
CMS3_k127_595548_1	867903.ThesuDRAFT_02300	1.395e-23	105.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,3WCCE@538999|Clostridiales incertae sedis	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CMS3_k127_5966942_1	706587.Desti_2066	1.268e-05	56.0	COG1807@1|root,COG1807@2|Bacteria,1NPGH@1224|Proteobacteria,4322Q@68525|delta/epsilon subdivisions,2WWF0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_5966942_0	404589.Anae109_4442	6.078e-12	79.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF222,HNH
CMS3_k127_5969870_2	742738.HMPREF9460_03624	6.734e-32	129.0	COG1703@1|root,COG1703@2|Bacteria,1TQT4@1239|Firmicutes,24944@186801|Clostridia,2691Z@186813|unclassified Clostridiales	186801|Clostridia	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
CMS3_k127_5969870_1	765177.Desmu_0529	1.059e-35	153.0	COG1319@1|root,arCOG01926@2157|Archaea,2XQPN@28889|Crenarchaeota	28889|Crenarchaeota	C	CO dehydrogenase flavoprotein domain protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
CMS3_k127_5969870_0	1499967.BAYZ01000154_gene1444	9.615e-39	155.0	COG2080@1|root,COG2080@2|Bacteria,2NPPX@2323|unclassified Bacteria	2|Bacteria	C	PFAM 2Fe-2S -binding	-	-	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CMS3_k127_5972598_3	671143.DAMO_3172	4.186e-37	156.0	COG0277@1|root,COG0277@2|Bacteria,2NP55@2323|unclassified Bacteria	2|Bacteria	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
CMS3_k127_5972598_1	1123242.JH636434_gene5053	5.621e-106	376.0	COG0247@1|root,COG0247@2|Bacteria,2IXBR@203682|Planctomycetes	203682|Planctomycetes	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
CMS3_k127_5972598_2	1142394.PSMK_09230	7.921e-46	181.0	COG1363@1|root,COG1363@2|Bacteria	2|Bacteria	G	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28,Peptidase_M42
CMS3_k127_5972598_0	526222.Desal_2757	1.069e-152	497.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2M7U6@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K01338,ko:K04076,ko:K04770	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Lon_C
CMS3_k127_5992514_2	666685.R2APBS1_1272	3.321e-09	59.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,1RNBX@1236|Gammaproteobacteria,1X45S@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA dehydrogenase	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_5992514_0	1167006.UWK_02488	3.507e-70	253.0	COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria	1224|Proteobacteria	G	Major facilitator Superfamily	MA20_01130	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS3_k127_5992514_1	391625.PPSIR1_31098	1.199e-38	145.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,42YUJ@68525|delta/epsilon subdivisions,2WTUY@28221|Deltaproteobacteria,2YVT1@29|Myxococcales	28221|Deltaproteobacteria	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
CMS3_k127_5998408_4	1379698.RBG1_1C00001G0315	9.725e-16	88.0	COG4942@1|root,COG4942@2|Bacteria,2NPDY@2323|unclassified Bacteria	2|Bacteria	D	Peptidase family M23	envC	GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
CMS3_k127_5998408_3	671143.DAMO_2528	3.991e-40	162.0	COG2177@1|root,COG2177@2|Bacteria,2NPIM@2323|unclassified Bacteria	2|Bacteria	D	Belongs to the ABC-4 integral membrane protein family. FtsX subfamily	ftsX	GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006928,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0032506,GO:0034097,GO:0040007,GO:0040011,GO:0042173,GO:0042221,GO:0043207,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0048870,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0071976,GO:0090529,GO:1902531	-	ko:K09811,ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
CMS3_k127_5998408_2	264732.Moth_0244	1.248e-68	245.0	COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,42EW3@68295|Thermoanaerobacterales	186801|Clostridia	D	TIGRFAM Cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
CMS3_k127_5998408_1	1297742.A176_01068	6.91e-69	239.0	COG3382@1|root,COG3382@2|Bacteria,1N6A7@1224|Proteobacteria,4337M@68525|delta/epsilon subdivisions,2WXR0@28221|Deltaproteobacteria,2YUZ2@29|Myxococcales	28221|Deltaproteobacteria	S	B3/4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
CMS3_k127_5998408_5	584708.Apau_1697	2.644e-14	76.0	COG1188@1|root,COG1188@2|Bacteria,3TBIC@508458|Synergistetes	508458|Synergistetes	J	S4 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	S4
CMS3_k127_5998408_6	1116375.VEJY3_18121	0.0002248	53.0	COG3055@1|root,COG3391@1|root,COG3055@2|Bacteria,COG3391@2|Bacteria,1QSB4@1224|Proteobacteria,1S2EP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Kelch repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,Kelch_4,Kelch_6
CMS3_k127_5998408_0	1042377.AFPJ01000007_gene1789	1.601e-154	507.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RPRP@1236|Gammaproteobacteria,464U8@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG2366 Protein related to penicillin acylase	quiP	-	3.5.1.11,3.5.1.97	ko:K01434,ko:K07116	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
CMS3_k127_6006524_0	502025.Hoch_6876	2.751e-56	211.0	COG0392@1|root,COG0392@2|Bacteria,1R4IS@1224|Proteobacteria,42WRK@68525|delta/epsilon subdivisions,2WSAB@28221|Deltaproteobacteria,2Z0VY@29|Myxococcales	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
CMS3_k127_6006524_1	1499967.BAYZ01000074_gene2083	7.124e-47	172.0	COG0451@1|root,COG0451@2|Bacteria,2NNNX@2323|unclassified Bacteria	2|Bacteria	GM	NAD(P)H-binding	wbpP	-	5.1.3.2,5.1.3.7	ko:K01784,ko:K02473	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R00418,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS3_k127_6012698_0	404589.Anae109_3729	5.015e-173	574.0	COG3202@1|root,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	HEAT_2,TLC,cNMP_binding
CMS3_k127_6032180_5	1210884.HG799466_gene12651	7.312e-06	51.0	2FGP8@1|root,348IU@2|Bacteria,2J3N9@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6032180_3	1479238.JQMZ01000001_gene395	2.286e-22	98.0	COG3655@1|root,COG3655@2|Bacteria,1N6VH@1224|Proteobacteria,2UFAM@28211|Alphaproteobacteria,43Y68@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K07727	-	-	-	-	ko00000,ko03000	-	-	-	HTH_26
CMS3_k127_6032180_1	861299.J421_6210	1.252e-46	190.0	COG0457@1|root,COG0457@2|Bacteria	861299.J421_6210|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6032180_2	1173027.Mic7113_1623	8.843e-41	157.0	COG2947@1|root,COG2947@2|Bacteria,1G63D@1117|Cyanobacteria,1HHB6@1150|Oscillatoriales	1117|Cyanobacteria	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
CMS3_k127_6032180_0	1123371.ATXH01000003_gene1949	8.252e-95	321.0	COG0265@1|root,COG0265@2|Bacteria,2GHRY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_6049353_0	313606.M23134_02452	2.638e-254	801.0	COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,47KZ5@768503|Cytophagia	976|Bacteroidetes	G	PFAM Glycosyl Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,F5_F8_type_C,Fn3_assoc,Glyco_hydro_92
CMS3_k127_6054785_0	861299.J421_1748	1.091e-69	252.0	2E4Q1@1|root,32ZIN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6054785_1	1123073.KB899243_gene574	2.278e-46	174.0	COG5553@1|root,COG5553@2|Bacteria,1R5RR@1224|Proteobacteria,1S0Y6@1236|Gammaproteobacteria,1X3J0@135614|Xanthomonadales	135614|Xanthomonadales	S	Cysteine dioxygenase type I	-	-	-	-	-	-	-	-	-	-	-	-	CDO_I
CMS3_k127_6054785_2	246969.TAM4_345	5.96e-44	166.0	COG0346@1|root,arCOG02706@2157|Archaea,2XY0R@28890|Euryarchaeota,24458@183968|Thermococci	183968|Thermococci	E	Glyoxalase-like domain	-	GO:0003674,GO:0003824,GO:0004493,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016853,GO:0016854,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046491,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
CMS3_k127_6054785_3	459349.CLOAM0984	1.156e-07	64.0	COG1361@1|root,COG1361@2|Bacteria,2NS3P@2323|unclassified Bacteria	2|Bacteria	M	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FlgD_ig,Peptidase_C25,Peptidase_C25_C,Propeptide_C25
CMS3_k127_6056965_1	356851.JOAN01000016_gene6166	4.979e-67	241.0	COG0438@1|root,COG0438@2|Bacteria,2GM53@201174|Actinobacteria,4D8SV@85008|Micromonosporales	201174|Actinobacteria	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_6056965_0	1170562.Cal6303_3088	3.147e-94	317.0	COG0673@1|root,COG0673@2|Bacteria,1G1CZ@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_6065082_0	489825.LYNGBM3L_21220	1.659e-274	863.0	COG1216@1|root,COG5309@1|root,COG1216@2|Bacteria,COG5309@2|Bacteria,1G2MT@1117|Cyanobacteria,1H8YG@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
CMS3_k127_6065082_1	1173026.Glo7428_0931	1.876e-134	442.0	COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_6072400_0	861299.J421_2707	1.826e-156	515.0	COG1022@1|root,COG1022@2|Bacteria,1ZT60@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
CMS3_k127_6072400_2	1128421.JAGA01000002_gene1502	5.937e-70	252.0	COG0611@1|root,COG0611@2|Bacteria,2NP8J@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU05900	AIRS,AIRS_C
CMS3_k127_6072400_1	1304883.KI912532_gene2007	4.416e-135	454.0	COG0744@1|root,COG0744@2|Bacteria,1NRPB@1224|Proteobacteria,2VJ7F@28216|Betaproteobacteria,2KVVR@206389|Rhodocyclales	206389|Rhodocyclales	M	COG0744 Membrane carboxypeptidase (penicillin-binding protein)	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
CMS3_k127_6089054_0	56780.SYN_03100	6.792e-44	171.0	2DM5T@1|root,31U0Y@2|Bacteria,1RJ9U@1224|Proteobacteria,42ZSQ@68525|delta/epsilon subdivisions,2WUZS@28221|Deltaproteobacteria,2MRKB@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
CMS3_k127_6089054_1	521011.Mpal_1784	2.249e-36	146.0	COG1520@1|root,COG3291@1|root,arCOG02515@1|root,arCOG02554@1|root,arCOG02482@2157|Archaea,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02515@2157|Archaea,arCOG02554@2157|Archaea	2157|Archaea	O	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CBM_6,CHB_HEX_C_1,DUF3344,NosD,PKD,PQQ_2,PQQ_3
CMS3_k127_6094616_1	1121472.AQWN01000001_gene182	1.071e-141	484.0	COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,2602M@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
CMS3_k127_6094616_2	580327.Tthe_1801	3.851e-116	387.0	COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,42EPG@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
CMS3_k127_6094616_6	1121335.Clst_1057	5.319e-40	152.0	COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia,3WIYY@541000|Ruminococcaceae	186801|Clostridia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
CMS3_k127_6094616_7	1121914.AUDW01000006_gene1557	2.127e-12	71.0	COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,4HNIQ@91061|Bacilli,3WF0E@539002|Bacillales incertae sedis	91061|Bacilli	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
CMS3_k127_6094616_5	1379698.RBG1_1C00001G1116	3.055e-55	203.0	COG0290@1|root,COG0290@2|Bacteria,2NPDH@2323|unclassified Bacteria	2|Bacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
CMS3_k127_6094616_0	313628.LNTAR_10061	4.532e-196	630.0	COG0441@1|root,COG0441@2|Bacteria	2|Bacteria	J	threonyl-tRNA aminoacylation	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
CMS3_k127_6094616_4	448385.sce3769	1.887e-73	259.0	COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,42NRH@68525|delta/epsilon subdivisions,2WNIB@28221|Deltaproteobacteria,2Z01C@29|Myxococcales	28221|Deltaproteobacteria	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
CMS3_k127_6094616_3	349741.Amuc_1636	3.078e-96	329.0	COG0617@1|root,COG0617@2|Bacteria,46S8B@74201|Verrucomicrobia,2ITTG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Poly A polymerase head domain	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
CMS3_k127_6099775_0	945713.IALB_2157	1.819e-177	584.0	COG1297@1|root,COG1297@2|Bacteria	2|Bacteria	S	iron-nicotianamine transmembrane transporter activity	oliA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085	-	-	-	-	-	-	-	-	-	-	OPT
CMS3_k127_6099775_1	404589.Anae109_1583	4.214e-56	210.0	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,42TE9@68525|delta/epsilon subdivisions,2WPGF@28221|Deltaproteobacteria,2YUH5@29|Myxococcales	28221|Deltaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS3_k127_6124705_6	78245.Xaut_1595	6.419e-27	117.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U5A1@28211|Alphaproteobacteria,3F1EC@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	Sigma-70, region 4	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6124705_1	1125863.JAFN01000001_gene1250	8.1e-141	464.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MXG@68525|delta/epsilon subdivisions,2WJ6G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS3_k127_6124705_0	1379698.RBG1_1C00001G1779	6.407e-149	483.0	COG0714@1|root,COG0714@2|Bacteria,2NNMQ@2323|unclassified Bacteria	2|Bacteria	S	ATPase associated with various cellular	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS3_k127_6124705_2	237368.SCABRO_01880	4.692e-105	357.0	COG1721@1|root,COG1721@2|Bacteria,2IXT7@203682|Planctomycetes	203682|Planctomycetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS3_k127_6124705_7	1121129.KB903359_gene1254	2.067e-19	103.0	COG3088@1|root,COG3088@2|Bacteria,4NGHU@976|Bacteroidetes,2FP8Y@200643|Bacteroidia,22XR6@171551|Porphyromonadaceae	976|Bacteroidetes	O	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6124705_5	880073.Calab_2474	5.436e-91	310.0	COG2304@1|root,COG2304@2|Bacteria,2NNYH@2323|unclassified Bacteria	2|Bacteria	NU	von Willebrand factor (vWF) type A domain	batA	-	-	ko:K07114,ko:K12511	-	-	-	-	ko00000,ko02000,ko02044	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
CMS3_k127_6124705_4	1379698.RBG1_1C00001G1774	2.444e-92	329.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,2NP2F@2323|unclassified Bacteria	2|Bacteria	S	von Willebrand factor (vWF) type A domain	batB	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
CMS3_k127_6124705_3	1379698.RBG1_1C00001G1773	3.712e-99	351.0	COG0457@1|root,COG0457@2|Bacteria,2NP5J@2323|unclassified Bacteria	2|Bacteria	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
CMS3_k127_6133010_3	448385.sce2021	1.763e-05	53.0	COG4970@1|root,COG4970@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	-	-	-	ko:K02246,ko:K08084	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.15.2	-	-	GspH,N_methyl
CMS3_k127_6133010_0	240015.ACP_2544	1.271e-138	454.0	COG1104@1|root,COG1104@2|Bacteria,3Y3CG@57723|Acidobacteria,2JI55@204432|Acidobacteriia	204432|Acidobacteriia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS3_k127_6133010_2	1382359.JIAL01000001_gene823	3.026e-23	108.0	COG0316@1|root,COG0316@2|Bacteria,3Y518@57723|Acidobacteria,2JJGN@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
CMS3_k127_6133010_1	1172188.KB911827_gene4335	1.638e-125	411.0	COG0379@1|root,COG0379@2|Bacteria,2GM59@201174|Actinobacteria,4FEYF@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
CMS3_k127_6145972_1	404589.Anae109_0046	2.055e-66	248.0	COG0451@1|root,COG0451@2|Bacteria,1MXYR@1224|Proteobacteria	1224|Proteobacteria	GM	Nad-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
CMS3_k127_6145972_4	1343739.PAP_08085	3.83e-20	99.0	COG0697@1|root,arCOG00271@2157|Archaea,2XY2J@28890|Euryarchaeota	28890|Euryarchaeota	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS3_k127_6145972_0	1501230.ET33_13240	3.475e-90	306.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.7.1.83	ko:K16328	ko00240,map00240	-	R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
CMS3_k127_6145972_3	326297.Sama_0384	2.889e-36	148.0	COG1506@1|root,COG1506@2|Bacteria,1QZ1F@1224|Proteobacteria	1224|Proteobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6145972_2	195250.CM001776_gene3334	5.56e-38	143.0	COG0346@1|root,COG0346@2|Bacteria,1GERF@1117|Cyanobacteria	1117|Cyanobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS3_k127_6188914_4	1202532.FF52_09002	3.762e-10	70.0	COG3637@1|root,COG3637@2|Bacteria,4NR9K@976|Bacteroidetes,1I34P@117743|Flavobacteriia,2NWCZ@237|Flavobacterium	976|Bacteroidetes	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl_2
CMS3_k127_6188914_1	1206741.BAFX01000183_gene7621	4.154e-66	241.0	COG0438@1|root,COG0438@2|Bacteria,2HFN4@201174|Actinobacteria,4G7AY@85025|Nocardiaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_6188914_3	1121904.ARBP01000001_gene5713	4.282e-28	121.0	2E1HF@1|root,32WVJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3996
CMS3_k127_6188914_0	368407.Memar_1357	7.846e-103	346.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia	224756|Methanomicrobia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_6188914_2	555779.Dthio_PD2268	1.048e-40	161.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42QFH@68525|delta/epsilon subdivisions,2WKWR@28221|Deltaproteobacteria,2M7U5@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Glycos_transf_2,Radical_SAM
CMS3_k127_6191607_0	234267.Acid_5749	1.208e-93	334.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
CMS3_k127_6191607_1	1166018.FAES_4084	3.959e-70	259.0	COG4775@1|root,COG4775@2|Bacteria,4NF38@976|Bacteroidetes,47KMS@768503|Cytophagia	976|Bacteroidetes	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_620382_1	292459.STH112	1.638e-11	71.0	COG2864@1|root,COG2864@2|Bacteria,1V757@1239|Firmicutes,24FMN@186801|Clostridia	186801|Clostridia	C	formate dehydrogenase	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
CMS3_k127_620382_0	204669.Acid345_0471	3.883e-184	597.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_621052_4	1125863.JAFN01000001_gene2827	1.308e-22	114.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	gnfL	-	2.7.13.3	ko:K02668,ko:K07708,ko:K07709	ko02020,map02020	M00497,M00499,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
CMS3_k127_621052_6	748658.KB907313_gene2363	5.823e-09	69.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,1X2AG@135613|Chromatiales	135613|Chromatiales	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc,PilZ
CMS3_k127_621052_2	247490.KSU1_C1270	1.076e-51	198.0	COG1262@1|root,COG1262@2|Bacteria,2IXQ0@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DZR,FGE-sulfatase,TPR_11
CMS3_k127_621052_0	266117.Rxyl_0222	8.369e-179	572.0	COG1953@1|root,COG1953@2|Bacteria,2GJXN@201174|Actinobacteria	201174|Actinobacteria	FH	permease for cytosine purines, uracil, thiamine, allantoin	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
CMS3_k127_621052_3	568816.Acin_1459	3.903e-47	174.0	COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,4H4C1@909932|Negativicutes	909932|Negativicutes	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
CMS3_k127_621052_1	756499.Desde_3893	5.931e-79	278.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,260BA@186807|Peptococcaceae	186801|Clostridia	C	electron transfer flavoprotein, alpha subunit	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
CMS3_k127_621052_5	1408254.T458_05260	3.353e-09	60.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,4H9QY@91061|Bacilli,26UCB@186822|Paenibacillaceae	91061|Bacilli	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
CMS3_k127_6225968_1	1254432.SCE1572_39760	1.351e-52	186.0	COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,42NWK@68525|delta/epsilon subdivisions,2WM2T@28221|Deltaproteobacteria,2YYFZ@29|Myxococcales	28221|Deltaproteobacteria	I	synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
CMS3_k127_6225968_3	941449.dsx2_0326	1.538e-08	68.0	COG0296@1|root,COG0296@2|Bacteria,1NEFK@1224|Proteobacteria,42VRH@68525|delta/epsilon subdivisions,2WRD5@28221|Deltaproteobacteria,2MC6U@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM glycoside hydrolase family 13 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
CMS3_k127_6225968_2	1121448.DGI_1947	4.029e-25	120.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42QZV@68525|delta/epsilon subdivisions,2WN5Z@28221|Deltaproteobacteria,2M8T8@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB40H-2	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
CMS3_k127_6225968_0	1452718.JBOY01000142_gene1502	1.818e-94	320.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed	atoB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS3_k127_6231644_1	5671.XP_001467459.1	7.864e-12	73.0	COG1986@1|root,2S3KM@2759|Eukaryota,3XUPF@5653|Kinetoplastida	5653|Kinetoplastida	F	Protein of unknown function DUF84	-	-	-	-	-	-	-	-	-	-	-	-	NTPase_I-T
CMS3_k127_6231644_0	269797.Mbar_A0416	5.382e-39	160.0	arCOG03561@1|root,arCOG03561@2157|Archaea,2Y1Q9@28890|Euryarchaeota,2N9M9@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,NHL
CMS3_k127_6241374_5	1033802.SSPSH_002801	2.124e-17	85.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
CMS3_k127_6241374_0	1379698.RBG1_1C00001G0407	2.089e-135	441.0	COG0823@1|root,COG0823@2|Bacteria,2NQA4@2323|unclassified Bacteria	2|Bacteria	U	Periplasmic component of the Tol biopolymer transport system	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PA,PD40,PDZ_2,Peptidase_M28
CMS3_k127_6241374_2	1415166.NONO_c70380	2.017e-58	212.0	COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,4FVV6@85025|Nocardiaceae	201174|Actinobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
CMS3_k127_6241374_4	204669.Acid345_1709	4.479e-34	144.0	COG0491@1|root,COG0491@2|Bacteria,3Y4D7@57723|Acidobacteria,2JKB5@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_6241374_1	1499967.BAYZ01000194_gene3127	1.597e-68	241.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
CMS3_k127_6241374_3	1124780.ANNU01000016_gene1821	2.47e-40	165.0	COG0729@1|root,COG0729@2|Bacteria,4NMUN@976|Bacteroidetes,47Y2C@768503|Cytophagia	976|Bacteroidetes	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
CMS3_k127_6241374_6	1479237.JMLY01000001_gene3211	9.6e-16	80.0	29QWA@1|root,30BWM@2|Bacteria,1REIR@1224|Proteobacteria,1S50N@1236|Gammaproteobacteria,468FT@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CBM_11,VanZ
CMS3_k127_6242285_0	1173023.KE650771_gene4388	3.283e-176	557.0	COG0277@1|root,COG0277@2|Bacteria,1G207@1117|Cyanobacteria	1117|Cyanobacteria	C	FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
CMS3_k127_6242285_2	1300345.LF41_1785	3.859e-19	97.0	COG1266@1|root,COG1266@2|Bacteria,1R5RA@1224|Proteobacteria,1S0ZC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
CMS3_k127_6242285_1	1278073.MYSTI_02808	7.67e-103	347.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria	1224|Proteobacteria	S	major pilin protein fima	MA20_16755	-	-	-	-	-	-	-	-	-	-	-	DUF1028
CMS3_k127_624513_1	638303.Thal_1002	2.687e-124	412.0	COG0635@1|root,COG0635@2|Bacteria,2G4M1@200783|Aquificae	200783|Aquificae	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS3_k127_624513_3	1288826.MSNKSG1_06828	4.487e-24	112.0	2B52F@1|root,31XVQ@2|Bacteria,1MYIZ@1224|Proteobacteria,1SPHQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114,VPEP
CMS3_k127_624513_2	1036674.A28LD_0671	1.489e-46	176.0	2DPEU@1|root,331SS@2|Bacteria,1NDKB@1224|Proteobacteria,1RTE7@1236|Gammaproteobacteria,2QG29@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Golgi phosphoprotein 3 (GPP34)	-	-	-	-	-	-	-	-	-	-	-	-	GPP34
CMS3_k127_624513_0	234267.Acid_5892	3.399e-153	497.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	B12-binding,Radical_SAM
CMS3_k127_6245839_2	713586.KB900536_gene2579	5.63e-104	356.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CMS3_k127_6245839_1	396588.Tgr7_0459	1.014e-117	394.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
CMS3_k127_6245839_0	713586.KB900536_gene2577	1.779e-149	500.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RNQN@1236|Gammaproteobacteria,1WX6D@135613|Chromatiales	135613|Chromatiales	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS3_k127_626878_2	671143.DAMO_1931	1.204e-46	182.0	COG1538@1|root,COG1538@2|Bacteria,2NPKK@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS3_k127_626878_1	517418.Ctha_2707	7.344e-56	209.0	COG0845@1|root,COG0845@2|Bacteria,1FE89@1090|Chlorobi	1090|Chlorobi	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
CMS3_k127_626878_0	177437.HRM2_47440	1.129e-148	481.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,2MIUG@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS3_k127_6278405_1	880073.Calab_0887	3.227e-74	254.0	COG1493@1|root,COG1493@2|Bacteria,2NP5B@2323|unclassified Bacteria	2|Bacteria	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
CMS3_k127_6278405_3	398767.Glov_2162	1.459e-08	62.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,42SST@68525|delta/epsilon subdivisions,2WPWN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM PTS system fructose subfamily IIA component	-	-	2.7.1.191	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1	-	-	EIIA-man
CMS3_k127_6278405_2	379066.GAU_1479	6.43e-21	99.0	COG3444@1|root,COG3444@2|Bacteria,1ZTQR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	PTS system sorbose subfamily IIB component	-	-	-	ko:K19507	ko02060,map02060	M00764	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1.19	-	-	PTSIIB_sorb
CMS3_k127_6278405_0	1150474.JQJI01000024_gene1593	2.07e-112	379.0	COG1449@1|root,COG1449@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	amyA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
CMS3_k127_6292379_0	67356.KL575631_gene7330	2.5e-69	250.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria	201174|Actinobacteria	M	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_6292379_1	926562.Oweho_0806	6.103e-26	115.0	2CHCP@1|root,32S5R@2|Bacteria,4NS9G@976|Bacteroidetes,1I4BI@117743|Flavobacteriia,2PBSI@246874|Cryomorphaceae	976|Bacteroidetes	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
CMS3_k127_6298493_2	546271.Selsp_1868	1.892e-24	111.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,4H2Y2@909932|Negativicutes	909932|Negativicutes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
CMS3_k127_6298493_1	439235.Dalk_1768	5.321e-53	196.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WNPT@28221|Deltaproteobacteria,2MIZH@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CMS3_k127_6298493_0	1379698.RBG1_1C00001G1004	5.89e-54	195.0	COG0772@1|root,COG0772@2|Bacteria,2NNRP@2323|unclassified Bacteria	2|Bacteria	D	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
CMS3_k127_6308978_1	85643.Tmz1t_1628	1.525e-08	66.0	COG0457@1|root,COG3063@1|root,COG0457@2|Bacteria,COG3063@2|Bacteria,1MXMD@1224|Proteobacteria,2VIMP@28216|Betaproteobacteria,2KV97@206389|Rhodocyclales	206389|Rhodocyclales	NU	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
CMS3_k127_6308978_0	290397.Adeh_1640	2.265e-80	286.0	COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,42M34@68525|delta/epsilon subdivisions,2WKJ6@28221|Deltaproteobacteria,2YX5K@29|Myxococcales	28221|Deltaproteobacteria	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
CMS3_k127_6308978_2	1957.JODX01000011_gene726	0.0007856	50.0	COG0457@1|root,COG0457@2|Bacteria,2GKS8@201174|Actinobacteria	201174|Actinobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_631758_2	1348662.CARG_05435	0.0001088	45.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,22K77@1653|Corynebacteriaceae	201174|Actinobacteria	M	Glycosyltransferase	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
CMS3_k127_631758_0	448385.sce7277	6.135e-125	418.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PCA@68525|delta/epsilon subdivisions,2WM39@28221|Deltaproteobacteria,2Z0ZC@29|Myxococcales	28221|Deltaproteobacteria	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS3_k127_631758_1	502025.Hoch_2444	1.203e-23	104.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2YVGD@29|Myxococcales	28221|Deltaproteobacteria	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
CMS3_k127_6324840_1	1121920.AUAU01000016_gene1278	9.986e-06	58.0	COG0840@1|root,COG2208@1|root,COG0840@2|Bacteria,COG2208@2|Bacteria,3Y2P9@57723|Acidobacteria	57723|Acidobacteria	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
CMS3_k127_6324840_0	483219.LILAB_09765	4.279e-112	381.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42N1B@68525|delta/epsilon subdivisions,2WJWS@28221|Deltaproteobacteria,2YTWC@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
CMS3_k127_6342697_0	525904.Tter_1099	1.666e-34	153.0	COG2856@1|root,COG2856@2|Bacteria,2NQY0@2323|unclassified Bacteria	2|Bacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6342697_1	635013.TherJR_2108	1.985e-19	102.0	COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,261PX@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_6342697_2	656024.FsymDg_4433	4.892e-05	54.0	COG5650@1|root,COG5650@2|Bacteria,2GJBC@201174|Actinobacteria,4ET2P@85013|Frankiales	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	ko:K13671	-	-	-	-	ko00000,ko01000,ko01003	-	GT87	-	GT87
CMS3_k127_6349545_0	880073.Calab_0665	1.267e-190	615.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2NNT2@2323|unclassified Bacteria	2|Bacteria	C	Transketolase, pyrimidine binding domain	CP_0743	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
CMS3_k127_6349545_1	483219.LILAB_23725	3.456e-134	449.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,2YY78@29|Myxococcales	28221|Deltaproteobacteria	T	Large family of predicted nucleotide-binding domains	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
CMS3_k127_6349545_2	1313304.CALK_2296	2.143e-33	136.0	COG1562@1|root,COG1562@2|Bacteria	2|Bacteria	I	ergosterol biosynthetic process	crtB	-	2.5.1.21,2.5.1.32,2.5.1.99	ko:K00801,ko:K02291,ko:K18163	ko00100,ko00906,ko00909,ko01062,ko01100,ko01110,ko01130,ko04714,map00100,map00906,map00909,map01062,map01100,map01110,map01130,map04714	M00097	R00702,R02065,R02872,R04218,R06223,R07270,R10177	RC00362,RC00796,RC01101,RC02839,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	SQS_PSY
CMS3_k127_6364549_1	1049564.TevJSym_aj00120	7.343e-81	277.0	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,1S6AN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KT	phosphohydrolase	rela3	-	-	-	-	-	-	-	-	-	-	-	HD_4
CMS3_k127_6364549_0	580340.Tlie_1159	3.468e-113	377.0	COG0460@1|root,COG0460@2|Bacteria,3TA0A@508458|Synergistetes	508458|Synergistetes	E	PFAM Homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
CMS3_k127_6364549_3	880073.Calab_2875	5.562e-14	72.0	COG0704@1|root,COG0704@2|Bacteria,2NPWX@2323|unclassified Bacteria	2|Bacteria	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
CMS3_k127_6368959_0	518766.Rmar_1115	1.172e-102	344.0	COG2008@1|root,COG2008@2|Bacteria,4NEIH@976|Bacteroidetes,1FIQX@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Beta-eliminating lyase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
CMS3_k127_6368959_3	1348635.BBJY01000006_gene373	9.139e-16	87.0	COG2346@1|root,COG2346@2|Bacteria,1QM27@1224|Proteobacteria,1TJ9G@1236|Gammaproteobacteria,1Y0UV@135623|Vibrionales	135623|Vibrionales	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
CMS3_k127_6368959_2	292415.Tbd_2082	8.436e-17	88.0	2DMII@1|root,32RTH@2|Bacteria	2|Bacteria	S	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,VPEP
CMS3_k127_6368959_4	391625.PPSIR1_11165	9.184e-06	55.0	2DEWU@1|root,2ZPJP@2|Bacteria,1PVUN@1224|Proteobacteria,4384A@68525|delta/epsilon subdivisions,2X3E6@28221|Deltaproteobacteria,2YVNZ@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6385703_1	945713.IALB_0802	4.167e-94	319.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6385703_3	983920.Y88_3325	1.303e-07	64.0	COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,2U31V@28211|Alphaproteobacteria,2K3PY@204457|Sphingomonadales	204457|Sphingomonadales	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6385703_0	404589.Anae109_2645	1.316e-129	439.0	COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,4397N@68525|delta/epsilon subdivisions,2X4EI@28221|Deltaproteobacteria,2YYVA@29|Myxococcales	28221|Deltaproteobacteria	C	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
CMS3_k127_6385703_2	880073.Calab_3335	7.369e-11	67.0	COG0492@1|root,COG0492@2|Bacteria	2|Bacteria	C	ferredoxin-NADP+ reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thioredoxin_3,cNMP_binding
CMS3_k127_6385703_4	1245469.S58_30880	0.0003575	48.0	COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1PR9I@1224|Proteobacteria,2U1SM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_6,Pyr_redox_3
CMS3_k127_6395464_1	518766.Rmar_2721	1.992e-103	352.0	COG2262@1|root,COG2262@2|Bacteria,4NF0P@976|Bacteroidetes,1FIUG@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
CMS3_k127_6395464_2	383372.Rcas_2505	3.595e-55	214.0	COG1807@1|root,COG1807@2|Bacteria,2G8IK@200795|Chloroflexi,375EI@32061|Chloroflexia	32061|Chloroflexia	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6395464_0	344747.PM8797T_30057	6.991e-117	388.0	COG1899@1|root,COG1899@2|Bacteria,2IYQN@203682|Planctomycetes	203682|Planctomycetes	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
CMS3_k127_6395464_3	215803.DB30_0693	2.9e-22	109.0	COG2885@1|root,COG2885@2|Bacteria,1R7WJ@1224|Proteobacteria,42QJK@68525|delta/epsilon subdivisions,2WJX0@28221|Deltaproteobacteria,2YWI7@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,TSP_3
CMS3_k127_6411093_1	562970.Btus_1825	2.609e-52	192.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,4HC7B@91061|Bacilli,278YZ@186823|Alicyclobacillaceae	91061|Bacilli	H	Lumazine binding domain	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08950,iYO844.BSU23270	Lum_binding
CMS3_k127_6411093_0	572477.Alvin_1772	5.878e-63	236.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1WVVQ@135613|Chromatiales	135613|Chromatiales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
CMS3_k127_6411093_2	243365.CV_0096	2.226e-34	143.0	COG2273@1|root,COG2273@2|Bacteria,1RD4E@1224|Proteobacteria	1224|Proteobacteria	G	Hydrolase Family 16	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6412642_0	1232410.KI421428_gene1054	5.421e-136	449.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria,43S25@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains REC, sigma54 interaction, HTH8	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_6412642_1	484770.UFO1_0202	6.223e-56	210.0	COG5000@1|root,COG5000@2|Bacteria,1VS6X@1239|Firmicutes	1239|Firmicutes	T	Histidine kinase	-	-	2.7.13.3	ko:K07710	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,dCache_1
CMS3_k127_6423322_0	378806.STAUR_4671	8.99e-122	403.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2WIR7@28221|Deltaproteobacteria,2YTYX@29|Myxococcales	28221|Deltaproteobacteria	C	dihydrolipoamide dehydrogenase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
CMS3_k127_6424557_1	243231.GSU2317	9.584e-59	213.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,43S4X@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
CMS3_k127_6424557_0	215803.DB30_1185	6.411e-126	410.0	COG0010@1|root,COG0010@2|Bacteria,1RCQX@1224|Proteobacteria,42R4M@68525|delta/epsilon subdivisions,2X5RQ@28221|Deltaproteobacteria,2YYRW@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
CMS3_k127_6447352_3	880073.Calab_1130	4.481e-82	287.0	COG1638@1|root,COG1638@2|Bacteria,2NS33@2323|unclassified Bacteria	2|Bacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	ko:K11688,ko:K21395	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
CMS3_k127_6447352_5	1121456.ATVA01000014_gene792	2.28e-27	119.0	COG3090@1|root,COG3090@2|Bacteria,1MZNX@1224|Proteobacteria,42TZJ@68525|delta/epsilon subdivisions,2WQB8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Tripartite ATP-independent periplasmic transporter, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
CMS3_k127_6447352_2	1167006.UWK_01424	8.504e-141	461.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2MI9P@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
CMS3_k127_6447352_1	880073.Calab_2352	2.695e-248	771.0	COG0334@1|root,COG0334@2|Bacteria,2NNTY@2323|unclassified Bacteria	2|Bacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	gdhA	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_6447352_4	768706.Desor_4046	1.053e-45	186.0	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,24IAA@186801|Clostridia	186801|Clostridia	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS3_k127_6447352_0	945713.IALB_0304	8.617e-289	917.0	COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PPDK_N,Response_reg,SpoIIE
CMS3_k127_6447352_6	264732.Moth_1646	4.263e-18	84.0	COG0624@1|root,COG0624@2|Bacteria,1TR99@1239|Firmicutes,248DC@186801|Clostridia,42FC4@68295|Thermoanaerobacterales	186801|Clostridia	E	Peptidase dimerisation domain	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
CMS3_k127_644944_1	1382315.JPOI01000001_gene698	1.277e-06	58.0	COG2318@1|root,COG2318@2|Bacteria,1V8A0@1239|Firmicutes,4HIW8@91061|Bacilli,1WGBX@129337|Geobacillus	91061|Bacilli	S	Protein of unknown function (DUF1569)	yuaE	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS3_k127_644944_0	644966.Tmar_1343	1.301e-92	321.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,3WCXQ@538999|Clostridiales incertae sedis	186801|Clostridia	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
CMS3_k127_645434_1	1267535.KB906767_gene2214	1.182e-95	327.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	vioA	GO:0005575,GO:0005576,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043207,GO:0044403,GO:0044419,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0075136,GO:0098771	2.6.1.33	ko:K13308,ko:K20429	ko00523,ko01130,map00523,map01130	M00797	R02773	RC00006,RC00781	ko00000,ko00001,ko00002,ko01000	-	-	-	DegT_DnrJ_EryC1
CMS3_k127_645434_0	743525.TSC_c03010	2.678e-135	445.0	COG1086@1|root,COG1086@2|Bacteria,1WIQA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
CMS3_k127_645434_2	1123278.KB893600_gene2767	8.658e-08	59.0	COG2374@1|root,COG4447@1|root,COG2374@2|Bacteria,COG4447@2|Bacteria,4NX71@976|Bacteroidetes,47W14@768503|Cytophagia	976|Bacteroidetes	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6455333_3	391037.Sare_1405	9.924e-10	64.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4DBBI@85008|Micromonosporales	201174|Actinobacteria	Q	Multicopper oxidase	-	-	1.3.3.5	ko:K08100	ko00860,ko01110,map00860,map01110	-	R02394	RC01983	ko00000,ko00001,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
CMS3_k127_6455333_2	880073.Calab_3071	4.163e-23	103.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11,Flg_new,SLH
CMS3_k127_6455333_0	1125863.JAFN01000001_gene1391	5.441e-142	477.0	COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1PEPK@1224|Proteobacteria,42NJ8@68525|delta/epsilon subdivisions,2WM57@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0348	Peptidase_M1
CMS3_k127_6455333_1	1125863.JAFN01000001_gene1391	9.117e-86	301.0	COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1PEPK@1224|Proteobacteria,42NJ8@68525|delta/epsilon subdivisions,2WM57@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0348	Peptidase_M1
CMS3_k127_6472868_1	1313265.JNIE01000004_gene418	4.123e-44	176.0	COG1924@1|root,COG1924@2|Bacteria,2G3VW@200783|Aquificae	200783|Aquificae	I	ATPase BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
CMS3_k127_6472868_0	608538.HTH_0935	3.812e-211	668.0	COG3581@1|root,COG3581@2|Bacteria,2G4PU@200783|Aquificae	200783|Aquificae	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6481573_0	1089550.ATTH01000001_gene2391	2.457e-30	136.0	COG0642@1|root,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes,1FJVE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
CMS3_k127_6481573_1	886293.Sinac_6595	5.096e-23	112.0	COG1807@1|root,COG3063@1|root,COG1807@2|Bacteria,COG3063@2|Bacteria,2J0A8@203682|Planctomycetes	203682|Planctomycetes	NU	O-linked GlcNAc transferase-putative TPR-containing transmembrane protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_6492022_2	1191523.MROS_1361	1.355e-24	117.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	4.2.2.3	ko:K01729	ko00051,map00051	-	R03706	-	ko00000,ko00001,ko01000	-	-	-	Chondroitinas_B
CMS3_k127_6492022_3	1463820.JOGW01000001_gene5446	6.605e-14	83.0	COG1409@1|root,COG5492@1|root,COG1409@2|Bacteria,COG5492@2|Bacteria,2GKTR@201174|Actinobacteria	201174|Actinobacteria	N	polysaccharide lyase family 8	-	-	4.2.2.1	ko:K01727	-	-	-	-	ko00000,ko01000	-	PL8	-	Lyase_8,Lyase_8_C,Lyase_8_N
CMS3_k127_6492022_0	745411.B3C1_10727	3.268e-194	625.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1J8W5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	oligopeptide transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
CMS3_k127_6492022_1	575540.Isop_0794	6.138e-52	191.0	COG1163@1|root,COG1163@2|Bacteria,2IWYP@203682|Planctomycetes	203682|Planctomycetes	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
CMS3_k127_6541022_1	867903.ThesuDRAFT_00082	6.402e-38	153.0	COG0329@1|root,COG0329@2|Bacteria,1TPSG@1239|Firmicutes,24H6N@186801|Clostridia	186801|Clostridia	EM	Belongs to the DapA family	-	-	4.1.3.16	ko:K18123	ko00330,ko00630,ko01100,map00330,map00630,map01100	-	R00470,R00471	RC00307,RC00308	ko00000,ko00001,ko01000	-	-	-	DHDPS
CMS3_k127_6541022_2	198467.NP92_01940	1.572e-31	141.0	COG0566@1|root,COG0566@2|Bacteria,1UZXJ@1239|Firmicutes,4HEW2@91061|Bacilli,21W1P@150247|Anoxybacillus	91061|Bacilli	J	Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA	trmH	-	2.1.1.34	ko:K00556	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
CMS3_k127_6541022_0	886293.Sinac_3668	1.654e-46	176.0	COG0534@1|root,COG0534@2|Bacteria,2IX5Q@203682|Planctomycetes	203682|Planctomycetes	V	COG0534 Na -driven multidrug efflux pump	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
CMS3_k127_6547490_0	266117.Rxyl_0566	9.71e-42	167.0	COG0438@1|root,COG0438@2|Bacteria,2I8FJ@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_6547490_1	404589.Anae109_3728	8.129e-40	160.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	1.8.1.9	ko:K00384,ko:K10914,ko:K16922	ko00450,ko02020,ko02024,ko02025,ko02026,ko05111,map00450,map02020,map02024,map02025,map02026,map05111	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko01002,ko03000	-	-	-	cNMP_binding
CMS3_k127_6565067_3	479434.Sthe_1579	8.001e-38	145.0	COG0251@1|root,COG0251@2|Bacteria,2G6XT@200795|Chloroflexi,27YDZ@189775|Thermomicrobia	189775|Thermomicrobia	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
CMS3_k127_6565067_4	1341155.FSS13T_21270	2.547e-06	58.0	28PR3@1|root,2ZCD0@2|Bacteria,4NMAF@976|Bacteroidetes,1I18T@117743|Flavobacteriia,2NSUZ@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6565067_0	518766.Rmar_2045	8.08e-267	835.0	COG0481@1|root,COG0481@2|Bacteria,4NEJ9@976|Bacteroidetes,1FIPT@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
CMS3_k127_6565067_1	1123376.AUIU01000012_gene1496	2.006e-60	216.0	COG0681@1|root,COG0681@2|Bacteria,3J0IP@40117|Nitrospirae	40117|Nitrospirae	U	Signal peptidase, peptidase S26	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
CMS3_k127_6565067_2	742817.HMPREF9449_02391	2.173e-44	171.0	COG0635@1|root,COG0635@2|Bacteria,4NFEE@976|Bacteroidetes,2FPFC@200643|Bacteroidia,22VY4@171551|Porphyromonadaceae	976|Bacteroidetes	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS3_k127_6577811_1	1410620.SHLA_25c000370	3.013e-07	63.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2USBQ@28211|Alphaproteobacteria,4BBR5@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	Peptidase C39 family	lagD	-	3.6.3.27	ko:K06021,ko:K20344	ko02010,ko02024,map02010,map02024	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.112	-	-	ABC_membrane,ABC_tran,Peptidase_C39
CMS3_k127_6577811_0	765914.ThisiDRAFT_0881	1.749e-82	285.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WWGD@135613|Chromatiales	135613|Chromatiales	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Sigma54_activat
CMS3_k127_658294_1	1121920.AUAU01000004_gene809	5.793e-98	331.0	COG0006@1|root,COG0006@2|Bacteria,3Y36W@57723|Acidobacteria	57723|Acidobacteria	E	peptidase M24B X-Pro dipeptidase aminopeptidase domain protein	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
CMS3_k127_658294_4	1150474.JQJI01000045_gene1614	3.145e-07	58.0	2FCRF@1|root,344UM@2|Bacteria,2GE8C@200918|Thermotogae	200918|Thermotogae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_658294_3	1232437.KL662038_gene2304	5.756e-51	193.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42NUP@68525|delta/epsilon subdivisions,2WKSD@28221|Deltaproteobacteria,2MNKG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	mscS-1	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
CMS3_k127_658294_2	756272.Plabr_4506	3.928e-63	228.0	COG0652@1|root,COG0652@2|Bacteria,2IZWK@203682|Planctomycetes	203682|Planctomycetes	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
CMS3_k127_658294_0	518766.Rmar_0089	1.225e-175	571.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_6597523_1	1122939.ATUD01000002_gene1367	2.451e-12	78.0	COG3325@1|root,COG3325@2|Bacteria,2IGIW@201174|Actinobacteria,4CPKA@84995|Rubrobacteria	84995|Rubrobacteria	G	Belongs to the glycosyl hydrolase 18 family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6597523_0	1183438.GKIL_3356	4.06e-145	482.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS3_k127_6598107_1	1236514.BAKL01000065_gene4256	2.351e-17	94.0	COG4249@1|root,COG4249@2|Bacteria,4PKVQ@976|Bacteroidetes,2G05C@200643|Bacteroidia,4AWEM@815|Bacteroidaceae	976|Bacteroidetes	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6598107_0	1121405.dsmv_0379	8.565e-168	548.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2WJ9N@28221|Deltaproteobacteria,2MHX8@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,TrkA_C,Voltage_CLC
CMS3_k127_6598107_2	471854.Dfer_2800	2.306e-16	89.0	COG0616@1|root,COG0616@2|Bacteria,4NES1@976|Bacteroidetes,47KQH@768503|Cytophagia	976|Bacteroidetes	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
CMS3_k127_6599032_1	682795.AciX8_1412	2.098e-57	209.0	COG2972@1|root,COG2972@2|Bacteria,3Y3NH@57723|Acidobacteria,2JHT4@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	5TM-5TMR_LYT,HATPase_c,His_kinase
CMS3_k127_6599032_2	574087.Acear_1035	9.78e-57	206.0	COG3279@1|root,COG3279@2|Bacteria,1V14X@1239|Firmicutes,24BG9@186801|Clostridia,3WAQ3@53433|Halanaerobiales	186801|Clostridia	K	Two component transcriptional regulator, LytTR family	-	-	-	ko:K02477,ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
CMS3_k127_6599032_4	237368.SCABRO_02044	3.776e-41	165.0	COG0428@1|root,COG0428@2|Bacteria,2IZ3C@203682|Planctomycetes	203682|Planctomycetes	P	ZIP Zinc transporter	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
CMS3_k127_6599032_0	1379698.RBG1_1C00001G0383	4.063e-65	235.0	COG0438@1|root,COG0438@2|Bacteria,2NQ17@2323|unclassified Bacteria	2|Bacteria	M	glycosyl transferase group 1	remC	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_6599032_5	204669.Acid345_2946	6.497e-36	156.0	COG2208@1|root,COG3437@1|root,COG2208@2|Bacteria,COG3437@2|Bacteria,3Y56X@57723|Acidobacteria,2JM0P@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,SpoIIE
CMS3_k127_6599032_3	290397.Adeh_0418	6.999e-43	182.0	COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,1QYFP@1224|Proteobacteria,43CBV@68525|delta/epsilon subdivisions,2X7MN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_3,HATPase_c,HisKA
CMS3_k127_6599032_6	215803.DB30_8469	5.638e-24	117.0	COG1729@1|root,COG1729@2|Bacteria,1N780@1224|Proteobacteria,42V4V@68525|delta/epsilon subdivisions,2WR6U@28221|Deltaproteobacteria,2YW0N@29|Myxococcales	28221|Deltaproteobacteria	S	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6606664_2	234267.Acid_0024	1.736e-64	233.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
CMS3_k127_6606664_3	551275.KB899544_gene914	8.937e-05	55.0	28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,2TUAV@28211|Alphaproteobacteria,43ZIZ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6606664_0	880073.Calab_3681	1.623e-244	768.0	COG3051@1|root,COG3051@2|Bacteria,2NP8D@2323|unclassified Bacteria	2|Bacteria	C	Citrate lyase, alpha subunit (CitF)	citF	-	2.8.3.10	ko:K01643	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	CitF
CMS3_k127_6606664_1	204669.Acid345_2963	6.878e-140	459.0	COG2301@1|root,COG3052@1|root,COG2301@2|Bacteria,COG3052@2|Bacteria,3Y8FI@57723|Acidobacteria,2JNED@204432|Acidobacteriia	204432|Acidobacteriia	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
CMS3_k127_6616745_6	234267.Acid_0495	1.826e-19	93.0	2EJZ3@1|root,33DPP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6616745_2	234267.Acid_0496	2.554e-79	275.0	COG1999@1|root,COG1999@2|Bacteria,3Y3XH@57723|Acidobacteria	57723|Acidobacteria	S	signal sequence binding	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
CMS3_k127_6616745_1	204669.Acid345_2996	1.496e-118	388.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,3Y2GR@57723|Acidobacteria,2JHRF@204432|Acidobacteriia	204432|Acidobacteriia	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
CMS3_k127_6616745_0	234267.Acid_0498	3.249e-272	845.0	COG0843@1|root,COG0843@2|Bacteria,3Y2X6@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
CMS3_k127_6616745_3	204669.Acid345_2994	2.164e-70	244.0	COG1845@1|root,COG1845@2|Bacteria,3Y414@57723|Acidobacteria,2JI50@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
CMS3_k127_6616745_7	1382359.JIAL01000001_gene967	2.147e-17	85.0	2DR0H@1|root,339NS@2|Bacteria,3Y59F@57723|Acidobacteria,2JJP9@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM Caa(3)-type oxidase, subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
CMS3_k127_6616745_4	314278.NB231_11914	2.399e-32	141.0	COG3137@1|root,COG3137@2|Bacteria,1RCKQ@1224|Proteobacteria,1S0GK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
CMS3_k127_6616745_5	326297.Sama_1484	4.414e-32	131.0	COG3137@1|root,COG3137@2|Bacteria,1RCKQ@1224|Proteobacteria,1S0GK@1236|Gammaproteobacteria,2QA2B@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
CMS3_k127_6626906_0	1286106.MPL1_11008	1.68e-273	854.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,4600V@72273|Thiotrichales	72273|Thiotrichales	E	Vitamin B12 dependent methionine synthase, activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
CMS3_k127_6627886_2	867845.KI911784_gene2183	2.337e-30	130.0	COG0012@1|root,COG0012@2|Bacteria,2G5UY@200795|Chloroflexi,376AC@32061|Chloroflexia	32061|Chloroflexia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
CMS3_k127_6627886_1	324925.Ppha_2152	5.832e-43	168.0	COG1595@1|root,COG1595@2|Bacteria,1FDU7@1090|Chlorobi	1090|Chlorobi	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_6627886_0	289377.HL41_09135	7.436e-87	298.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,2GGVM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
CMS3_k127_6630773_3	690850.Desaf_2821	4.057e-35	140.0	COG0726@1|root,COG0726@2|Bacteria,1RH3I@1224|Proteobacteria,42T75@68525|delta/epsilon subdivisions,2WPC1@28221|Deltaproteobacteria,2MEZ8@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Archaea-specific editing domain of threonyl-tRNA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-Thr_ED
CMS3_k127_6630773_1	879212.DespoDRAFT_03349	1.143e-153	512.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2WJ3T@28221|Deltaproteobacteria,2MHMX@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS3_k127_6630773_0	247490.KSU1_A0037	8.781e-173	566.0	COG0367@1|root,COG0367@2|Bacteria,2IXAI@203682|Planctomycetes	203682|Planctomycetes	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS3_k127_6630773_2	1144932.ATTF01000017_gene1171	6.227e-41	160.0	COG1285@1|root,COG1285@2|Bacteria,1PD3I@1224|Proteobacteria,2UKD1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
CMS3_k127_6645874_0	1049564.TevJSym_aj00120	6.628e-55	197.0	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,1S6AN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KT	phosphohydrolase	rela3	-	-	-	-	-	-	-	-	-	-	-	HD_4
CMS3_k127_6645874_1	234267.Acid_4431	7.192e-48	194.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
CMS3_k127_6673750_3	953739.SVEN_4246	0.0008042	51.0	COG0739@1|root,COG0823@1|root,COG0739@2|Bacteria,COG0823@2|Bacteria,2GZMS@201174|Actinobacteria	201174|Actinobacteria	MU	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	PD40,VCBS
CMS3_k127_6673750_2	1449357.JQLK01000001_gene214	8.84e-26	113.0	COG0801@1|root,COG0801@2|Bacteria,1WJU9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	TIGRFAM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
CMS3_k127_6673750_0	1144275.COCOR_06037	7.521e-71	246.0	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria	1224|Proteobacteria	F	Deoxynucleoside kinase	dgk	-	-	-	-	-	-	-	-	-	-	-	dNK
CMS3_k127_6673750_1	1382356.JQMP01000001_gene1202	1.045e-56	202.0	COG0413@1|root,COG0413@2|Bacteria,2G5TQ@200795|Chloroflexi,27XR8@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
CMS3_k127_6683424_2	861299.J421_1261	3.182e-83	290.0	COG0612@1|root,COG0612@2|Bacteria,1ZT7N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16_C
CMS3_k127_6683424_0	379066.GAU_0129	6.689e-119	402.0	COG0612@1|root,COG0612@2|Bacteria,1ZT1J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_6683424_4	662479.C440_04593	2.869e-05	56.0	COG2244@1|root,arCOG02209@2157|Archaea,2XVVS@28890|Euryarchaeota,23UCY@183963|Halobacteria	183963|Halobacteria	S	Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
CMS3_k127_6683424_3	1382359.JIAL01000001_gene928	3.476e-66	232.0	COG0110@1|root,COG0110@2|Bacteria,3Y5CT@57723|Acidobacteria,2JNBI@204432|Acidobacteriia	204432|Acidobacteriia	JM	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
CMS3_k127_6683424_1	1183438.GKIL_2151	8.664e-91	319.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
CMS3_k127_6685128_1	880073.Calab_3331	2.154e-37	161.0	2919D@1|root,2ZNWG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6685128_0	945713.IALB_0571	4.244e-42	171.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	ntcA	-	-	ko:K01420,ko:K10716,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko02000,ko03000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	HTH_Crp_2,cNMP_binding
CMS3_k127_6685690_0	1379698.RBG1_1C00001G1605	2.125e-273	856.0	COG0085@1|root,COG0085@2|Bacteria,2NNM9@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03043,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
CMS3_k127_6685690_2	580340.Tlie_0449	8.042e-41	154.0	COG0222@1|root,COG0222@2|Bacteria,3TB80@508458|Synergistetes	508458|Synergistetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
CMS3_k127_6685690_1	867903.ThesuDRAFT_00549	8.664e-43	162.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,3WCJV@538999|Clostridiales incertae sedis	186801|Clostridia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
CMS3_k127_6716760_1	1198114.AciX9_1400	1.601e-153	504.0	COG1132@1|root,COG1132@2|Bacteria,3Y32T@57723|Acidobacteria,2JIBZ@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter, transmembrane	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
CMS3_k127_6716760_0	671143.DAMO_2494	4.602e-167	553.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	MdlB	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS3_k127_6720763_1	1236518.BAKP01000004_gene484	2.156e-25	122.0	COG1611@1|root,COG1611@2|Bacteria,4NRW5@976|Bacteroidetes,2FQSJ@200643|Bacteroidia	976|Bacteroidetes	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS3_k127_6720763_0	1232410.KI421412_gene169	3.604e-205	647.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NQ1@68525|delta/epsilon subdivisions,2X5KW@28221|Deltaproteobacteria,43SYA@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
CMS3_k127_6720763_2	1121015.N789_03735	4.084e-07	53.0	COG1834@1|root,COG1834@2|Bacteria,1MZ9U@1224|Proteobacteria,1RN0M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
CMS3_k127_6725511_7	1123251.ATWM01000006_gene2129	0.0004618	50.0	COG2348@1|root,COG2348@2|Bacteria,2GJUD@201174|Actinobacteria,4FFD3@85021|Intrasporangiaceae	201174|Actinobacteria	V	FemAB family	femX	-	2.3.2.10	ko:K05363,ko:K18354	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	R08779	RC00055,RC00096	ko00000,ko00001,ko00002,ko01000,ko01011,ko01504	-	-	-	FemAB
CMS3_k127_6725511_1	1121439.dsat_1294	3.927e-77	273.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,2MD02@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Glu Leu Phe Val dehydrogenase , Glu Leu Phe Val dehydrogenase dimerization region	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,ELFV_dehydrog,ELFV_dehydrog_N
CMS3_k127_6725511_3	706587.Desti_1480	9.95e-63	224.0	COG1024@1|root,COG1024@2|Bacteria,1R8QP@1224|Proteobacteria,42S3Y@68525|delta/epsilon subdivisions,2WNXJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	bamR	-	4.2.1.100	ko:K07537	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05597	RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
CMS3_k127_6725511_0	1122176.KB903541_gene156	1.918e-104	362.0	COG0708@1|root,COG0708@2|Bacteria,4NM12@976|Bacteroidetes	976|Bacteroidetes	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS3_k127_6725511_2	861299.J421_0690	1.339e-65	229.0	2AYX9@1|root,31R2Z@2|Bacteria,1ZTNZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS3_k127_6725511_4	324602.Caur_3283	7.323e-43	162.0	COG0454@1|root,COG0456@2|Bacteria,2GB7E@200795|Chloroflexi,377FB@32061|Chloroflexia	32061|Chloroflexia	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_6725511_5	349521.HCH_06631	3.137e-24	111.0	2DQIT@1|root,33749@2|Bacteria,1N9CN@1224|Proteobacteria,1ST3J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
CMS3_k127_6737574_2	1298867.AUES01000022_gene2880	3.571e-23	104.0	COG4566@1|root,COG4566@2|Bacteria,1N5R5@1224|Proteobacteria,2UE41@28211|Alphaproteobacteria,3K0DI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS3_k127_6737574_1	891968.Anamo_1626	1.036e-85	301.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS3_k127_6737574_0	1379698.RBG1_1C00001G1677	1.005e-107	356.0	COG3239@1|root,COG3239@2|Bacteria,2NNTZ@2323|unclassified Bacteria	2|Bacteria	I	Fatty acid desaturase	des	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
CMS3_k127_673883_1	1131269.AQVV01000036_gene1493	2.919e-149	479.0	COG0086@1|root,COG0086@2|Bacteria	2|Bacteria	K	DNA-directed 5'-3' RNA polymerase activity	rpoC	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
CMS3_k127_673883_0	1379698.RBG1_1C00001G1605	5.214e-243	763.0	COG0085@1|root,COG0085@2|Bacteria,2NNM9@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03043,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
CMS3_k127_6767725_1	1211114.ALIP01000079_gene646	1.963e-27	120.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1X459@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
CMS3_k127_6767725_0	493475.GARC_4550	4.895e-50	188.0	COG1506@1|root,COG2374@1|root,COG1506@2|Bacteria,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,1RMHH@1236|Gammaproteobacteria,46500@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Extracellular nuclease	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Big_5,Endonuclease_1,Exo_endo_phos,LTD
CMS3_k127_6767725_2	1330700.JQNC01000003_gene1229	5.373e-22	106.0	COG1324@1|root,COG1324@2|Bacteria,1WKG6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	PFAM CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
CMS3_k127_6772262_1	1379698.RBG1_1C00001G0675	4.299e-73	260.0	COG1748@1|root,COG1748@2|Bacteria,2NPF8@2323|unclassified Bacteria	2|Bacteria	E	Saccharopine dehydrogenase C-terminal domain	lysDH	-	1.4.1.18	ko:K19064	ko00960,ko01100,ko01110,map00960,map01100,map01110	-	R00446,R02317	RC00062,RC00694	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
CMS3_k127_6772262_0	518766.Rmar_1680	5.761e-94	312.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,4NFUD@976|Bacteroidetes,1FIWE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	HP	ThiF family	moeZ	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
CMS3_k127_6778696_0	935863.AWZR01000003_gene2771	1.264e-221	715.0	COG3408@1|root,COG3408@2|Bacteria,1QU1Q@1224|Proteobacteria,1RRX2@1236|Gammaproteobacteria,1X4YN@135614|Xanthomonadales	135614|Xanthomonadales	G	coagulation factor 5 8 type	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,F5_F8_type_C,GDE_C
CMS3_k127_6778696_1	1211114.ALIP01000042_gene499	6.755e-76	258.0	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,1S4G6@1236|Gammaproteobacteria,1X3NS@135614|Xanthomonadales	135614|Xanthomonadales	P	ABC-type sugar transport system, permease component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS3_k127_6784019_3	1123401.JHYQ01000028_gene3199	3.408e-31	132.0	COG0220@1|root,COG0220@2|Bacteria,1QVWK@1224|Proteobacteria,1S7J8@1236|Gammaproteobacteria,460TB@72273|Thiotrichales	72273|Thiotrichales	J	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_6784019_0	316067.Geob_2120	2.106e-142	467.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,43TN4@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_0922	CTP_transf_like,PfkB
CMS3_k127_6784019_1	316067.Geob_3483	3.956e-60	214.0	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,43ADJ@68525|delta/epsilon subdivisions,2WMPS@28221|Deltaproteobacteria,43TG6@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_0920	SIS_2
CMS3_k127_6784019_2	1379698.RBG1_1C00001G0529	8.466e-33	137.0	COG0520@1|root,COG0520@2|Bacteria,2NP4B@2323|unclassified Bacteria	2|Bacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS3_k127_680369_0	1379698.RBG1_1C00001G0679	5.026e-120	391.0	COG2192@1|root,COG2192@2|Bacteria,2NNRR@2323|unclassified Bacteria	2|Bacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CMS3_k127_680369_3	1379698.RBG1_1C00001G0680	1.119e-12	74.0	2EGPU@1|root,31UHW@2|Bacteria,2NRWE@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_680369_1	324925.Ppha_0258	6.54e-73	260.0	COG0438@1|root,COG0438@2|Bacteria,1FE7C@1090|Chlorobi	1090|Chlorobi	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
CMS3_k127_680369_4	926569.ANT_17320	0.0001258	55.0	29XJU@1|root,30JAW@2|Bacteria,2G9DS@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6806857_2	518766.Rmar_0089	4.502e-30	135.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS3_k127_6806857_1	1207063.P24_08649	1.073e-48	178.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2U99Y@28211|Alphaproteobacteria,2JSN1@204441|Rhodospirillales	204441|Rhodospirillales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
CMS3_k127_6806857_3	525257.HMPREF0204_10417	0.0004578	51.0	COG3137@1|root,COG3137@2|Bacteria,4NGB2@976|Bacteroidetes,1HY5S@117743|Flavobacteriia,3ZPSH@59732|Chryseobacterium	976|Bacteroidetes	M	Protein of unknown function (DUF3078)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3078
CMS3_k127_6806857_0	716928.AJQT01000077_gene940	1.392e-177	563.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria,4BDDU@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Peptidase family M41	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CMS3_k127_6812183_1	517722.AEUE01000001_gene2499	3.346e-58	217.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria,2K0R5@204457|Sphingomonadales	204457|Sphingomonadales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
CMS3_k127_6812183_0	644282.Deba_1365	2.354e-99	344.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	PFAM SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
CMS3_k127_6812183_2	1121472.AQWN01000002_gene2267	1.218e-56	211.0	COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,261MS@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04225	Formyl_trans_N
CMS3_k127_6812183_3	1134413.ANNK01000114_gene1945	3.939e-16	82.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,4H9M4@91061|Bacilli,1ZBWR@1386|Bacillus	91061|Bacilli	S	Competence protein ComEC	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
CMS3_k127_6813578_0	1366050.N234_32720	7.577e-131	422.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria,1K2TY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6813578_3	748247.AZKH_0458	3.731e-18	94.0	COG1977@1|root,COG1977@2|Bacteria,1N9QE@1224|Proteobacteria,2VVR6@28216|Betaproteobacteria,2KXHZ@206389|Rhodocyclales	206389|Rhodocyclales	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
CMS3_k127_6813578_2	443598.AUFA01000004_gene5150	1.347e-48	192.0	COG0793@1|root,COG0793@2|Bacteria,1MX41@1224|Proteobacteria,2U26V@28211|Alphaproteobacteria,3JZYP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Tricorn protease homolog	-	-	3.4.21.102	ko:K03797,ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,PDZ_2,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
CMS3_k127_6813578_1	1121123.AUAO01000003_gene2394	2.154e-122	407.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,2KIF5@204458|Caulobacterales	204458|Caulobacterales	E	Membrane dipeptidase (Peptidase family M19)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M19
CMS3_k127_6822155_0	945713.IALB_2155	7.964e-131	434.0	COG2195@1|root,COG2195@2|Bacteria	2|Bacteria	E	Cleaves the N-terminal amino acid of tripeptides	pepD	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	iPC815.YPO3230,iSBO_1134.SBO_0243	M20_dimer,Peptidase_M20
CMS3_k127_6822155_3	1223410.KN050846_gene405	1.976e-08	67.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,4NGEX@976|Bacteroidetes,1HZV9@117743|Flavobacteriia	976|Bacteroidetes	U	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6822155_1	1254432.SCE1572_26700	1.171e-72	260.0	COG3396@1|root,COG3396@2|Bacteria,1Q169@1224|Proteobacteria,4374A@68525|delta/epsilon subdivisions,2X3NW@28221|Deltaproteobacteria,2YWPZ@29|Myxococcales	28221|Deltaproteobacteria	S	Phenylacetate-CoA oxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6822155_2	1123070.KB899249_gene273	2.321e-32	143.0	COG0782@1|root,COG1747@1|root,COG0782@2|Bacteria,COG1747@2|Bacteria,46S7F@74201|Verrucomicrobia,2ITY2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Transcription elongation factor, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB,GreA_GreB_N
CMS3_k127_6837813_0	243231.GSU0580	1.034e-310	974.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,43TQ2@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS3_k127_6837813_4	797302.Halru_3121	1.851e-13	84.0	COG1253@1|root,arCOG00626@2157|Archaea,2XT1Z@28890|Euryarchaeota,23S5R@183963|Halobacteria	183963|Halobacteria	S	COG1253 Hemolysins and related proteins containing CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
CMS3_k127_6837813_1	1449126.JQKL01000011_gene3579	3.242e-67	245.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,268U9@186813|unclassified Clostridiales	186801|Clostridia	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
CMS3_k127_6837813_2	1125863.JAFN01000001_gene536	3.801e-41	166.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42UES@68525|delta/epsilon subdivisions,2WQD1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM glycosyl transferase family 9	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CMS3_k127_6837813_3	379066.GAU_0725	2.905e-34	145.0	COG1519@1|root,COG1519@2|Bacteria,1ZSXB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
CMS3_k127_684303_3	876044.IMCC3088_635	2.701e-11	75.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1MWNX@1224|Proteobacteria,1RQHG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,LZ_Tnp_IS481,rve
CMS3_k127_684303_0	1123368.AUIS01000033_gene1370	8.136e-108	357.0	COG0426@1|root,COG0426@2|Bacteria,1MXIE@1224|Proteobacteria	1224|Proteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS3_k127_684303_2	331869.BAL199_18058	8.096e-19	94.0	COG1309@1|root,COG1309@2|Bacteria,1RBV0@1224|Proteobacteria,2U7VY@28211|Alphaproteobacteria,4BT49@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_684303_1	1279009.ADICEAN_02310	3.032e-48	176.0	COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,47KZ5@768503|Cytophagia	976|Bacteroidetes	G	PFAM Glycosyl Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_92
CMS3_k127_6843364_2	378806.STAUR_1288	3.35e-47	180.0	COG3358@1|root,COG3358@2|Bacteria,1RBIA@1224|Proteobacteria,4384Y@68525|delta/epsilon subdivisions,2X9XK@28221|Deltaproteobacteria,2YVS9@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
CMS3_k127_6843364_0	926560.KE387027_gene562	3.358e-131	426.0	COG0113@1|root,COG0113@2|Bacteria,1WINH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
CMS3_k127_6843364_3	649747.HMPREF0083_00366	5.899e-14	82.0	COG1587@1|root,COG1587@2|Bacteria,1UHSJ@1239|Firmicutes,4ITCT@91061|Bacilli,277CB@186822|Paenibacillaceae	91061|Bacilli	H	Uroporphyrinogen-III synthase HemD	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
CMS3_k127_6843364_1	1321781.HMPREF1985_00077	2.492e-100	357.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,4H2Z8@909932|Negativicutes	909932|Negativicutes	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
CMS3_k127_6843364_4	215803.DB30_3947	1.522e-07	64.0	COG3509@1|root,COG3509@2|Bacteria,1MXUI@1224|Proteobacteria,430Q8@68525|delta/epsilon subdivisions,2WVYQ@28221|Deltaproteobacteria,2YU06@29|Myxococcales	28221|Deltaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
CMS3_k127_6845123_3	880073.Calab_2485	6.439e-08	56.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,Fn3-like,Glyco_hydro_3_C,SLH
CMS3_k127_6845123_0	655811.HMPREF0078_0214	4.606e-78	277.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,22GBK@1570339|Peptoniphilaceae	186801|Clostridia	C	dehydrogenase	bcd	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_6845123_1	443143.GM18_0717	3.223e-56	217.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
CMS3_k127_6845123_2	671143.DAMO_0301	3.084e-25	120.0	COG0457@1|root,COG4745@1|root,COG0457@2|Bacteria,COG4745@2|Bacteria,2NQJ6@2323|unclassified Bacteria	2|Bacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL,PMT_2,TPR_2,TPR_8
CMS3_k127_6852977_1	765420.OSCT_1792	2.324e-35	139.0	COG0196@1|root,COG0196@2|Bacteria,2G6JF@200795|Chloroflexi,374TG@32061|Chloroflexia	32061|Chloroflexia	H	TIGRFAM riboflavin biosynthesis protein RibF	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
CMS3_k127_6852977_2	1499967.BAYZ01000080_gene915	2.829e-34	134.0	COG0184@1|root,COG0184@2|Bacteria,2NPTZ@2323|unclassified Bacteria	2|Bacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
CMS3_k127_6852977_0	1131269.AQVV01000001_gene1389	2.376e-226	726.0	COG1185@1|root,COG1185@2|Bacteria	2|Bacteria	J	polyribonucleotide nucleotidyltransferase activity	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
CMS3_k127_686827_1	926550.CLDAP_19010	5.592e-90	299.0	COG2818@1|root,COG2818@2|Bacteria,2G78E@200795|Chloroflexi	200795|Chloroflexi	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
CMS3_k127_686827_0	1121104.AQXH01000001_gene2028	0.0	1114.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1IQYT@117747|Sphingobacteriia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS3_k127_686827_3	518766.Rmar_0880	1.628e-53	203.0	COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,1FJ10@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
CMS3_k127_686827_2	1121930.AQXG01000001_gene1200	2.085e-60	233.0	COG1538@1|root,COG1538@2|Bacteria,4NF4X@976|Bacteroidetes	976|Bacteroidetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS3_k127_686827_4	1173026.Glo7428_4540	3.049e-22	105.0	COG1309@1|root,COG1309@2|Bacteria,1G4S5@1117|Cyanobacteria	1117|Cyanobacteria	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS3_k127_6869241_4	1122169.AREN01000008_gene773	4.15e-24	111.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1JDVY@118969|Legionellales	118969|Legionellales	E	indole-3-glycerol-phosphate synthase activity	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
CMS3_k127_6869241_0	1535422.ND16A_3444	1.796e-103	348.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,2Q8CP@267889|Colwelliaceae	1236|Gammaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
CMS3_k127_6869241_2	1191523.MROS_0613	9.434e-39	156.0	COG0755@1|root,COG0755@2|Bacteria	2|Bacteria	O	cytochrome complex assembly	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
CMS3_k127_6869241_1	945713.IALB_0543	2.693e-91	315.0	COG0373@1|root,COG0373@2|Bacteria	2|Bacteria	H	glutamyl-tRNA reductase activity	hemA	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	1.2.1.70	ko:K02407,ko:K02492	ko00860,ko01100,ko01110,ko01120,ko02040,map00860,map01100,map01110,map01120,map02040	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000,ko02035	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
CMS3_k127_6869241_3	393595.ABO_2322	2.692e-26	111.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1XI0C@135619|Oceanospirillales	135619|Oceanospirillales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
CMS3_k127_6875539_5	518766.Rmar_1712	2.843e-35	141.0	COG0352@1|root,COG0352@2|Bacteria,4NNFB@976|Bacteroidetes,1FJ8Z@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin,TMP-TENI
CMS3_k127_6875539_4	518766.Rmar_2095	1.661e-73	260.0	COG0351@1|root,COG0351@2|Bacteria,4NE0F@976|Bacteroidetes,1FIQS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
CMS3_k127_6875539_3	926569.ANT_14480	3.518e-91	308.0	COG1975@1|root,COG1975@2|Bacteria,2G6H0@200795|Chloroflexi	200795|Chloroflexi	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
CMS3_k127_6875539_2	452637.Oter_1528	1.177e-93	315.0	COG4555@1|root,COG4555@2|Bacteria	2|Bacteria	CP	ABC transporter	natA	-	3.6.3.7	ko:K01990,ko:K09697	ko02010,ko02020,map02010,map02020	M00253,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.115	-	iYO844.BSU02750	ABC_tran
CMS3_k127_6875539_1	452637.Oter_1529	1.606e-101	347.0	COG1668@1|root,COG1668@2|Bacteria,46VFH@74201|Verrucomicrobia	74201|Verrucomicrobia	CP	ABC-2 family transporter protein	-	-	-	ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	ABC2_membrane_3
CMS3_k127_6875539_0	330214.NIDE3178	2.386e-102	345.0	COG0464@1|root,COG0464@2|Bacteria	2|Bacteria	O	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS3_k127_6878947_0	266117.Rxyl_3086	2.39e-11	74.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	ahyR	-	-	ko:K07782,ko:K15852	ko02020,ko02024,ko02026,map02020,map02024,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	Autoind_bind,GerE
CMS3_k127_6878947_1	1173027.Mic7113_5158	9.556e-08	58.0	COG0457@1|root,COG0457@2|Bacteria,1G39E@1117|Cyanobacteria,1H8XZ@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_2,TPR_8
CMS3_k127_6880681_1	1379698.RBG1_1C00001G0108	1.313e-30	123.0	COG0803@1|root,COG0803@2|Bacteria,2NPH3@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the bacterial solute-binding protein 9 family	znuA	-	-	ko:K02077,ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
CMS3_k127_6880681_0	234267.Acid_0827	2.644e-66	236.0	COG1108@1|root,COG1108@2|Bacteria,3Y93X@57723|Acidobacteria	57723|Acidobacteria	P	ABC 3 transport family	-	-	-	ko:K02075	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
CMS3_k127_6886786_2	562970.Btus_2079	2.791e-33	132.0	COG0454@1|root,COG0456@2|Bacteria,1V562@1239|Firmicutes,4HMAE@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
CMS3_k127_6886786_1	522306.CAP2UW1_1074	3.8e-56	216.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,2WEJI@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Ion transport 2 domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
CMS3_k127_6886786_0	96561.Dole_2292	7.463e-152	506.0	COG0025@1|root,COG0569@1|root,COG0025@2|Bacteria,COG0569@2|Bacteria,1QTUE@1224|Proteobacteria,43BRM@68525|delta/epsilon subdivisions,2WM4A@28221|Deltaproteobacteria,2MHXR@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger,TrkA_N
CMS3_k127_6887401_1	945713.IALB_1181	1.32e-77	269.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	UPF0164
CMS3_k127_6887401_0	1123276.KB893245_gene1108	2.159e-125	420.0	COG5368@1|root,COG5368@2|Bacteria,4NE34@976|Bacteroidetes,47M1C@768503|Cytophagia	976|Bacteroidetes	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF3131,Glycoamylase
CMS3_k127_6887401_2	316067.Geob_0814	4.221e-19	103.0	COG1361@1|root,COG1520@1|root,COG1657@1|root,COG4257@1|root,COG4733@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG1657@2|Bacteria,COG4257@2|Bacteria,COG4733@2|Bacteria,1QYWJ@1224|Proteobacteria,43CDC@68525|delta/epsilon subdivisions,2X7P6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
CMS3_k127_6902690_1	237368.SCABRO_00708	1.502e-54	195.0	COG1671@1|root,COG1671@2|Bacteria,2IZRB@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the UPF0178 family	-	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
CMS3_k127_6902690_0	1265505.ATUG01000002_gene1433	5.092e-128	430.0	COG3023@1|root,COG3023@2|Bacteria,1PD4C@1224|Proteobacteria,42PQW@68525|delta/epsilon subdivisions,2WK9V@28221|Deltaproteobacteria,2MI3K@213118|Desulfobacterales	28221|Deltaproteobacteria	V	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
CMS3_k127_6902690_2	1249997.JHZW01000002_gene1835	4.15e-32	138.0	COG0421@1|root,COG0421@2|Bacteria	2|Bacteria	E	spermidine synthase activity	speE	GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
CMS3_k127_6903689_1	234267.Acid_3794	2.674e-09	70.0	COG3266@1|root,COG3266@2|Bacteria,3Y4N4@57723|Acidobacteria	57723|Acidobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
CMS3_k127_6906320_2	373903.Hore_18260	1.642e-09	70.0	COG0296@1|root,COG0296@2|Bacteria,1VTPY@1239|Firmicutes,24Z69@186801|Clostridia,3WB8U@53433|Halanaerobiales	186801|Clostridia	G	Glycogen recognition site of AMP-activated protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
CMS3_k127_6906320_0	443143.GM18_3369	4.023e-141	462.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,43TKB@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_6906320_1	1191523.MROS_1634	2.268e-17	97.0	COG0457@1|root,COG0457@2|Bacteria	1191523.MROS_1634|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_6910171_0	379066.GAU_2797	2.009e-278	875.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1ZT89@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
CMS3_k127_6910171_3	518766.Rmar_1352	1.541e-51	188.0	COG1898@1|root,COG1898@2|Bacteria	2|Bacteria	M	dTDP-4-dehydrorhamnose 3,5-epimerase activity	rfbC	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
CMS3_k127_6910171_4	671143.DAMO_0343	9.281e-16	83.0	COG1314@1|root,COG1314@2|Bacteria,2NPYV@2323|unclassified Bacteria	2|Bacteria	U	Preprotein translocase SecG subunit	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
CMS3_k127_6910171_2	1144275.COCOR_05244	4.568e-81	285.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,42MIF@68525|delta/epsilon subdivisions,2WIQF@28221|Deltaproteobacteria,2YU88@29|Myxococcales	28221|Deltaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
CMS3_k127_6910171_1	1519464.HY22_01240	7.178e-121	394.0	COG0126@1|root,COG0126@2|Bacteria,1FDBD@1090|Chlorobi	1090|Chlorobi	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
CMS3_k127_6917893_0	1123256.KB907927_gene1718	1.467e-21	106.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,1RQSM@1236|Gammaproteobacteria,1XCPR@135614|Xanthomonadales	135614|Xanthomonadales	M	Polysaccharide biosynthesis/export protein	-	-	-	-	-	-	-	-	-	-	-	-	Poly_export,SLBB
CMS3_k127_6917893_1	525897.Dbac_2584	2.18e-11	77.0	COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,42M2D@68525|delta/epsilon subdivisions,2WJU6@28221|Deltaproteobacteria,2MG98@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Chain length determinant protein	wzc1	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
CMS3_k127_6930357_3	118173.KB235914_gene660	5.173e-05	54.0	COG0845@1|root,COG0845@2|Bacteria,1G01U@1117|Cyanobacteria,1H98V@1150|Oscillatoriales	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23,OEP
CMS3_k127_6930357_2	880073.Calab_0631	3.152e-08	66.0	COG3292@1|root,COG3292@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3,Reg_prop,Y_Y_Y,YceI
CMS3_k127_6930357_0	448385.sce4861	3.191e-33	145.0	COG5337@1|root,COG5337@2|Bacteria,1Q378@1224|Proteobacteria,438XY@68525|delta/epsilon subdivisions,2X9VC@28221|Deltaproteobacteria,2YY5I@29|Myxococcales	28221|Deltaproteobacteria	M	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH
CMS3_k127_6930357_1	1278078.G419_19835	1.499e-09	64.0	COG5036@1|root,COG5036@2|Bacteria,2GKBU@201174|Actinobacteria,4FYJY@85025|Nocardiaceae	201174|Actinobacteria	P	VTC domain	-	-	-	-	-	-	-	-	-	-	-	-	VTC
CMS3_k127_6937451_0	269796.Rru_A3104	4.922e-117	407.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,2JR3B@204441|Rhodospirillales	204441|Rhodospirillales	T	Sigma-54 interaction domain	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_6937451_3	269799.Gmet_1993	1.42e-57	230.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,42PTN@68525|delta/epsilon subdivisions,2WKBJ@28221|Deltaproteobacteria,43SC3@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_3,HATPase_c
CMS3_k127_6937451_5	1260251.SPISAL_07065	0.0002037	54.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales	135613|Chromatiales	U	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
CMS3_k127_6937451_1	1479237.JMLY01000001_gene2547	3.074e-95	321.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,1RREJ@1236|Gammaproteobacteria,4663C@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	xylanase chitin deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
CMS3_k127_6937451_4	1249627.D779_3216	1.72e-16	93.0	COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,1RQYZ@1236|Gammaproteobacteria,1WX9D@135613|Chromatiales	135613|Chromatiales	C	eight transmembrane protein EpsH	-	-	-	-	-	-	-	-	-	-	-	-	DUF3485,Exosortase_EpsH
CMS3_k127_6937451_2	1125863.JAFN01000001_gene383	6.883e-58	213.0	COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,42R3N@68525|delta/epsilon subdivisions,2WMY8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	eight transmembrane protein EpsH	epsH	-	-	-	-	-	-	-	-	-	-	-	DUF3485,Exosortase_EpsH
CMS3_k127_694366_0	383372.Rcas_3108	3.807e-79	269.0	COG2148@1|root,COG2148@2|Bacteria,2G66B@200795|Chloroflexi,376EB@32061|Chloroflexia	32061|Chloroflexia	M	PFAM sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
CMS3_k127_694366_1	1388763.O165_008245	1.431e-66	243.0	COG1215@1|root,COG1215@2|Bacteria,1QUFX@1224|Proteobacteria,1RN4M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG1215 Glycosyltransferases, probably involved in cell wall biogenesis	sypQ	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
CMS3_k127_694366_2	1380390.JIAT01000010_gene4360	4.567e-59	224.0	COG2244@1|root,COG2244@2|Bacteria,2I4II@201174|Actinobacteria,4CTZ7@84995|Rubrobacteria	84995|Rubrobacteria	S	Polysaccharide biosynthesis C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
CMS3_k127_694366_4	526225.Gobs_0360	2.264e-08	66.0	COG3173@1|root,COG3173@2|Bacteria,2H3VQ@201174|Actinobacteria	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS3_k127_694366_3	1158050.KB895461_gene2929	5.052e-22	110.0	COG3173@1|root,COG3173@2|Bacteria,2H3VQ@201174|Actinobacteria	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS3_k127_6946742_0	1122176.KB903576_gene4913	1.323e-176	567.0	COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,1IQ09@117747|Sphingobacteriia	976|Bacteroidetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
CMS3_k127_6946742_1	1379698.RBG1_1C00001G0607	3.498e-70	247.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
CMS3_k127_6955798_1	870187.Thini_3011	1.388e-95	331.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,461R7@72273|Thiotrichales	72273|Thiotrichales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_6955798_2	292459.STH976	2.559e-76	263.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia	186801|Clostridia	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_6955798_3	1286631.X805_28860	3.432e-60	223.0	COG0845@1|root,COG0845@2|Bacteria,1MV1R@1224|Proteobacteria,2VHJC@28216|Betaproteobacteria,1KMMN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
CMS3_k127_6955798_0	404589.Anae109_3011	8.699e-260	819.0	COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,2YU3V@29|Myxococcales	28221|Deltaproteobacteria	G	glycosyl transferase family	otsAB	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,S6PP,Trehalose_PPase
CMS3_k127_6955798_4	258594.RPA3933	0.0005045	47.0	COG0745@1|root,COG5000@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TWK5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HWE_HK,HisKA,PAS_4,Reg_prop,Response_reg
CMS3_k127_6965331_2	1123368.AUIS01000024_gene948	1.738e-121	394.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,2NCCI@225057|Acidithiobacillales	225057|Acidithiobacillales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS3_k127_6965331_1	1123368.AUIS01000024_gene949	4.784e-144	480.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,2NBU9@225057|Acidithiobacillales	225057|Acidithiobacillales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
CMS3_k127_6965331_0	1123368.AUIS01000024_gene950	3.211e-150	495.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,2NCJF@225057|Acidithiobacillales	225057|Acidithiobacillales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
CMS3_k127_6979678_1	1121405.dsmv_2608	9.203e-155	494.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	-	-	2.5.1.76,4.2.3.1	ko:K01733,ko:K15527	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,PALP
CMS3_k127_6979678_2	1121405.dsmv_2609	9.11e-151	486.0	COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,42PSH@68525|delta/epsilon subdivisions,2WJYZ@28221|Deltaproteobacteria,2MIFM@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
CMS3_k127_6979678_0	1121405.dsmv_2611	3.405e-288	915.0	COG0603@1|root,COG1402@1|root,COG0603@2|Bacteria,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2X9RQ@28221|Deltaproteobacteria,2MPA0@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
CMS3_k127_6979678_3	1121405.dsmv_2612	1.285e-128	420.0	COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,42Q93@68525|delta/epsilon subdivisions,2WKAA@28221|Deltaproteobacteria,2MJ2T@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
CMS3_k127_6979678_4	118173.KB235914_gene3352	4.046e-66	230.0	COG2343@1|root,COG2343@2|Bacteria,1G50P@1117|Cyanobacteria,1HAMP@1150|Oscillatoriales	1117|Cyanobacteria	S	COGs COG2343 conserved	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
CMS3_k127_6979678_5	215803.DB30_7217	1.283e-10	73.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS3_k127_698017_2	1169143.KB911035_gene2453	3.169e-82	281.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VJIJ@28216|Betaproteobacteria,1JZQJ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
CMS3_k127_698017_1	269799.Gmet_2620	1.646e-148	478.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,42MJI@68525|delta/epsilon subdivisions,2WJQP@28221|Deltaproteobacteria,43UD6@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	6-phosphogluconate dehydrogenase, C-terminal domain	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2620	6PGD,NAD_binding_2
CMS3_k127_698017_0	530564.Psta_0883	6.939e-152	494.0	COG1236@1|root,COG1236@2|Bacteria,2IXNS@203682|Planctomycetes	203682|Planctomycetes	J	Exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
CMS3_k127_6986152_2	110662.Syncc9605_2524	1.39e-07	63.0	COG2931@1|root,COG2931@2|Bacteria,1G1I0@1117|Cyanobacteria,1GZV9@1129|Synechococcus	1117|Cyanobacteria	Q	Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind,Peptidase_M10_C
CMS3_k127_6986152_0	292459.STH2818	1.649e-75	269.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
CMS3_k127_6986152_1	1231190.NA8A_05828	3.491e-26	108.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2TS40@28211|Alphaproteobacteria,43HD7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
CMS3_k127_6990830_0	234267.Acid_1201	4.011e-128	427.0	COG3591@1|root,COG3591@2|Bacteria,3Y2TU@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
CMS3_k127_6990830_3	161156.JQKW01000006_gene1234	6.502e-26	120.0	COG0859@1|root,COG2227@1|root,COG0859@2|Bacteria,COG2227@2|Bacteria,2GHC1@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	HM	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
CMS3_k127_6990830_2	331113.SNE_A09700	1.058e-35	143.0	COG2154@1|root,COG2154@2|Bacteria,2JGH7@204428|Chlamydiae	204428|Chlamydiae	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
CMS3_k127_6990830_1	227086.JGI_V11_55451	2.681e-38	145.0	COG0605@1|root,KOG0876@2759|Eukaryota	2759|Eukaryota	P	oxidoreductase activity, acting on superoxide radicals as acceptor	SODB1	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
CMS3_k127_7023741_1	945713.IALB_2034	2.585e-73	254.0	COG0733@1|root,COG0733@2|Bacteria	2|Bacteria	S	neurotransmitter:sodium symporter activity	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
CMS3_k127_7023741_0	518766.Rmar_2586	1.309e-80	283.0	COG0479@1|root,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
CMS3_k127_7044675_2	319225.Plut_0173	1.093e-21	104.0	COG5617@1|root,COG5617@2|Bacteria,1FDV6@1090|Chlorobi	1090|Chlorobi	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
CMS3_k127_7044675_1	1379698.RBG1_1C00001G0996	7.183e-86	301.0	COG0463@1|root,COG0463@2|Bacteria,2NS3Y@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase like family 2	dpm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
CMS3_k127_7044675_0	1499967.BAYZ01000063_gene6022	1.791e-142	481.0	COG1216@1|root,COG2148@1|root,COG1216@2|Bacteria,COG2148@2|Bacteria,2NP9Z@2323|unclassified Bacteria	2|Bacteria	GM	Glycosyltransferase like family 2	-	-	-	ko:K03606,ko:K07011	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,CoA_binding_3,Glyco_tranf_2_3,Glycos_transf_2
CMS3_k127_7044675_3	1219375.CM002139_gene3211	3.544e-06	60.0	COG2199@1|root,COG3292@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,1R9NB@1224|Proteobacteria,1S1MC@1236|Gammaproteobacteria,1XCAK@135614|Xanthomonadales	135614|Xanthomonadales	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Reg_prop,Y_Y_Y
CMS3_k127_707018_2	1163408.UU9_12982	4.063e-19	91.0	COG2835@1|root,COG2835@2|Bacteria,1P6IM@1224|Proteobacteria,1SV7D@1236|Gammaproteobacteria,1X7IE@135614|Xanthomonadales	135614|Xanthomonadales	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
CMS3_k127_707018_0	251229.Chro_0270	2.639e-87	297.0	COG2084@1|root,COG2084@2|Bacteria,1G34X@1117|Cyanobacteria,3VN43@52604|Pleurocapsales	1117|Cyanobacteria	I	PFAM NAD binding domain of 6-phosphogluconate dehydrogenase	mmsB	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
CMS3_k127_707018_1	1123278.KB893388_gene5776	3.599e-47	176.0	COG2318@1|root,COG2318@2|Bacteria,4NNQA@976|Bacteroidetes,47Q00@768503|Cytophagia	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS3_k127_707018_3	203119.Cthe_0876	1.654e-16	93.0	COG1807@1|root,COG1807@2|Bacteria,1UYMG@1239|Firmicutes,247PB@186801|Clostridia	186801|Clostridia	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_707018_4	1379698.RBG1_1C00001G1816	1.286e-05	55.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,2NR9R@2323|unclassified Bacteria	2|Bacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT_2,TPR_8
CMS3_k127_7073310_0	190650.CC_3726	0.0002069	54.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria,2KF6H@204458|Caulobacterales	204458|Caulobacterales	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
CMS3_k127_7094744_0	264732.Moth_0532	6.074e-255	808.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,42ET0@68295|Thermoanaerobacterales	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
CMS3_k127_7094744_1	880073.Calab_2727	6.506e-41	167.0	COG0382@1|root,COG0382@2|Bacteria,2NQZV@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	ubiA	-	2.5.1.39,2.5.1.42	ko:K03179,ko:K17105	ko00130,ko00564,ko01100,ko01110,map00130,map00564,map01100,map01110	M00117	R04520,R05000,R05615	RC00209,RC01171,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
CMS3_k127_7094744_2	1379698.RBG1_1C00001G1726	2.258e-23	115.0	29YZ1@1|root,30KVZ@2|Bacteria,2NRNQ@2323|unclassified Bacteria	2|Bacteria	S	Capsule assembly protein Wzi	-	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi
CMS3_k127_7094744_3	118161.KB235922_gene1026	3.232e-20	104.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1G0YS@1117|Cyanobacteria	1117|Cyanobacteria	O	O-linked N-acetylglucosamine transferase SPINDLY family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,Sulfotransfer_2,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
CMS3_k127_7104195_0	243231.GSU2569	7.849e-62	221.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2WK6B@28221|Deltaproteobacteria,43SZM@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
CMS3_k127_7104195_1	402880.MmarC5_0901	6.186e-12	74.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota,23RCX@183939|Methanococci	183939|Methanococci	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
CMS3_k127_7104195_2	1121875.KB907547_gene3028	1.82e-06	56.0	COG2067@1|root,COG2067@2|Bacteria,4NEP1@976|Bacteroidetes,1HXXP@117743|Flavobacteriia	976|Bacteroidetes	I	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7105768_2	379066.GAU_1468	7.31e-101	339.0	COG0524@1|root,COG0524@2|Bacteria,1ZSUT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CMS3_k127_7105768_1	1304874.JAFY01000005_gene1251	2.27e-137	456.0	COG0018@1|root,COG0018@2|Bacteria,3TA5K@508458|Synergistetes	508458|Synergistetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
CMS3_k127_7105768_4	517418.Ctha_0064	3.2e-34	135.0	COG0799@1|root,COG0799@2|Bacteria,1FE3F@1090|Chlorobi	1090|Chlorobi	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
CMS3_k127_7105768_5	1232410.KI421412_gene65	4.443e-21	104.0	COG4769@1|root,COG4769@2|Bacteria,1RJIB@1224|Proteobacteria,42UKZ@68525|delta/epsilon subdivisions,2WQ3H@28221|Deltaproteobacteria,43SPR@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Heptaprenyl diphosphate synthase component I	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
CMS3_k127_7105768_6	396588.Tgr7_2907	0.0001369	51.0	COG5341@1|root,COG5341@2|Bacteria,1N1PN@1224|Proteobacteria,1SHVA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	NusG domain II	-	-	-	-	-	-	-	-	-	-	-	-	NusG_II
CMS3_k127_7105768_3	335543.Sfum_1586	2.127e-63	233.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,42M1B@68525|delta/epsilon subdivisions,2WK2M@28221|Deltaproteobacteria,2MQBX@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K02523,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
CMS3_k127_7105768_0	575540.Isop_2730	1.067e-208	659.0	COG2719@1|root,COG2719@2|Bacteria,2IXSH@203682|Planctomycetes	203682|Planctomycetes	S	PFAM SpoVR like protein	-	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
CMS3_k127_7112449_0	1340493.JNIF01000003_gene3558	4.685e-201	631.0	COG1164@1|root,COG1164@2|Bacteria,3Y2SB@57723|Acidobacteria	57723|Acidobacteria	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
CMS3_k127_7113415_1	1449346.JQMO01000002_gene581	2.953e-06	59.0	COG1277@1|root,COG1277@2|Bacteria,2I1PU@201174|Actinobacteria,2M4RN@2063|Kitasatospora	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
CMS3_k127_7113415_0	219305.MCAG_05178	1.526e-66	237.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4D8QU@85008|Micromonosporales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_7113415_2	391735.Veis_0283	4.968e-06	59.0	COG0346@1|root,COG0346@2|Bacteria,1MZT5@1224|Proteobacteria	1224|Proteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
CMS3_k127_7125976_3	671143.DAMO_0822	2.306e-59	224.0	COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
CMS3_k127_7125976_5	525904.Tter_1772	3.415e-23	114.0	COG3153@1|root,COG3153@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
CMS3_k127_7125976_2	1279009.ADICEAN_01391	6.275e-119	398.0	COG0812@1|root,COG0812@2|Bacteria,4NE78@976|Bacteroidetes,47KJJ@768503|Cytophagia	976|Bacteroidetes	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
CMS3_k127_7125976_0	880073.Calab_1598	0.0	1217.0	COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria	2|Bacteria	P	Prokaryotic cytochrome b561	cbcY	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese
CMS3_k127_7125976_1	880073.Calab_1599	6.592e-132	445.0	COG2864@1|root,COG2864@2|Bacteria,2NNNM@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b subunit of formate dehydrogenase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
CMS3_k127_7125976_4	1232410.KI421424_gene1754	2.484e-26	109.0	COG3005@1|root,COG3005@2|Bacteria,1R956@1224|Proteobacteria,42Q0X@68525|delta/epsilon subdivisions,2WMHI@28221|Deltaproteobacteria,43TAB@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
CMS3_k127_714483_5	596151.DesfrDRAFT_0648	1.328e-35	140.0	COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42X9Z@68525|delta/epsilon subdivisions,2WSPW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Rieske 2Fe-2S	cbcV	-	1.10.9.1	ko:K02636	ko00195,ko01100,map00195,map01100	M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske
CMS3_k127_714483_0	641491.DND132_0695	2.049e-107	381.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WMNX@28221|Deltaproteobacteria,2MEFN@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Cytochrome b b6 domain	cbcP	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_N_2,Cytochrome_B
CMS3_k127_714483_2	886293.Sinac_6278	9.427e-43	181.0	COG4219@1|root,COG4219@2|Bacteria,2J205@203682|Planctomycetes	203682|Planctomycetes	KT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56,Thioredoxin_7
CMS3_k127_714483_3	886293.Sinac_6279	1.261e-40	154.0	COG3682@1|root,COG3682@2|Bacteria,2J0QT@203682|Planctomycetes	203682|Planctomycetes	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
CMS3_k127_714483_4	204669.Acid345_2317	1.686e-39	151.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	2.7.11.1	ko:K04757,ko:K17752	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c,HATPase_c_2,Response_reg,SpoIIE
CMS3_k127_714483_1	1219084.AP014508_gene1160	2.206e-68	241.0	COG1404@1|root,COG1404@2|Bacteria,2GDZM@200918|Thermotogae	200918|Thermotogae	O	Subtilase family	-	-	3.4.21.62	ko:K01342	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
CMS3_k127_7147455_1	1382315.JPOI01000001_gene642	9.281e-72	248.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,4HANB@91061|Bacilli,1WEYR@129337|Geobacillus	91061|Bacilli	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CMS3_k127_7147455_2	1304885.AUEY01000002_gene348	1.295e-25	117.0	COG0389@1|root,COG0389@2|Bacteria,1NEMK@1224|Proteobacteria,42X8R@68525|delta/epsilon subdivisions,2WRT5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Pathogenicity locus	-	-	-	-	-	-	-	-	-	-	-	-	Cdd1
CMS3_k127_7147455_4	1234664.AMRO01000027_gene1215	6.96e-19	93.0	2AFVE@1|root,315XY@2|Bacteria,1V9WC@1239|Firmicutes,4HJ2Y@91061|Bacilli,1WHEF@129337|Geobacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7147455_0	522306.CAP2UW1_0198	2.084e-146	471.0	COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,2VN83@28216|Betaproteobacteria	28216|Betaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
CMS3_k127_7147455_3	404589.Anae109_0046	1.385e-25	109.0	COG0451@1|root,COG0451@2|Bacteria,1MXYR@1224|Proteobacteria	1224|Proteobacteria	GM	Nad-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
CMS3_k127_7171343_3	269799.Gmet_3465	6.465e-10	69.0	COG1538@1|root,COG1538@2|Bacteria,1PDZP@1224|Proteobacteria,42MJH@68525|delta/epsilon subdivisions,2WJ2X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
CMS3_k127_7171343_1	1123368.AUIS01000024_gene946	3.25e-107	362.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RS3I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Secretion protein	yhiI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS3_k127_7171343_0	1123368.AUIS01000024_gene947	9.419e-122	399.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,2NDPN@225057|Acidithiobacillales	225057|Acidithiobacillales	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_7171343_2	1278073.MYSTI_04097	1.525e-15	88.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WK9W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990,ko:K01992,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC2_membrane_3,ABC_tran
CMS3_k127_7175216_6	468059.AUHA01000004_gene2315	6.198e-06	55.0	COG2017@1|root,COG2017@2|Bacteria,4NE32@976|Bacteroidetes,1IZKH@117747|Sphingobacteriia	976|Bacteroidetes	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7175216_1	1192034.CAP_7003	2.94e-133	441.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Cys Met metabolism	-	-	2.5.1.48,4.4.1.11,4.4.1.8	ko:K01739,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
CMS3_k127_7175216_0	448385.sce3157	1.614e-201	647.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIND@28221|Deltaproteobacteria,2YUEV@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	GATase,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS3_k127_7175216_3	1128421.JAGA01000001_gene2144	1.027e-60	217.0	COG3127@1|root,COG3127@2|Bacteria	2|Bacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS3_k127_7175216_5	1128421.JAGA01000001_gene2145	2.829e-33	135.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	MA20_05735	-	-	-	-	-	-	-	-	-	-	-	HTH_34
CMS3_k127_7175216_2	234267.Acid_6294	1.611e-74	259.0	COG0020@1|root,COG0020@2|Bacteria,3Y4GH@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
CMS3_k127_7175216_4	886293.Sinac_1548	4.403e-47	176.0	COG0564@1|root,COG0564@2|Bacteria,2IZYH@203682|Planctomycetes	203682|Planctomycetes	J	Pseudouridine synthase	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
CMS3_k127_7182166_2	765420.OSCT_2272	3.225e-22	100.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi,376XE@32061|Chloroflexia	32061|Chloroflexia	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS3_k127_7182166_0	1499967.BAYZ01000118_gene3248	1.521e-48	189.0	COG0845@1|root,COG0845@2|Bacteria,2NR8R@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3,HlyD_D23
CMS3_k127_7182166_1	398767.Glov_0749	7.431e-28	129.0	COG1538@1|root,COG1538@2|Bacteria,1R705@1224|Proteobacteria,42V98@68525|delta/epsilon subdivisions,2WRX2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS3_k127_7182166_3	28072.Nos7524_1738	3.716e-15	78.0	COG0438@1|root,COG0438@2|Bacteria,1G271@1117|Cyanobacteria,1HPCT@1161|Nostocales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	icsA	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_7187808_2	1192034.CAP_8990	7.842e-17	86.0	COG1807@1|root,COG1807@2|Bacteria,1NPGH@1224|Proteobacteria,434QI@68525|delta/epsilon subdivisions,2X8Z6@28221|Deltaproteobacteria,2Z152@29|Myxococcales	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7187808_0	404589.Anae109_2748	0.0	1559.0	COG0493@1|root,COG0543@1|root,COG1633@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,COG1633@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM glutamate synthase (NADPH), homotetrameric	nfnA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
CMS3_k127_7187808_1	926569.ANT_28850	3.345e-38	148.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	ycaO	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	OsmC,YcaO
CMS3_k127_7191120_0	686340.Metal_3843	3.959e-70	259.0	COG4262@1|root,COG4262@2|Bacteria,1QUK8@1224|Proteobacteria,1T460@1236|Gammaproteobacteria,1XEF0@135618|Methylococcales	135618|Methylococcales	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7195918_1	479434.Sthe_2317	1.111e-112	375.0	COG0154@1|root,COG0154@2|Bacteria,2G7S4@200795|Chloroflexi,27YVX@189775|Thermomicrobia	189775|Thermomicrobia	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
CMS3_k127_7195918_3	448385.sce8116	2.188e-73	258.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42NY7@68525|delta/epsilon subdivisions,2WIXK@28221|Deltaproteobacteria,2Z364@29|Myxococcales	28221|Deltaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
CMS3_k127_7195918_5	240015.ACP_0124	5.701e-21	93.0	COG3369@1|root,COG3369@2|Bacteria,3Y5KG@57723|Acidobacteria,2JJXU@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Iron sulphur-containing domain, CDGSH-type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
CMS3_k127_7195918_4	266117.Rxyl_2055	2.018e-29	123.0	COG2127@1|root,COG2127@2|Bacteria	2|Bacteria	T	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
CMS3_k127_7195918_2	448385.sce4660	1.444e-73	264.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,43BMH@68525|delta/epsilon subdivisions,2X6ZP@28221|Deltaproteobacteria,2Z3JZ@29|Myxococcales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS3_k127_7195918_0	234267.Acid_1998	5.041e-143	460.0	COG0667@1|root,COG0667@2|Bacteria,3Y35T@57723|Acidobacteria	57723|Acidobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS3_k127_7195918_8	219305.MCAG_01591	0.0009133	46.0	COG0443@1|root,COG0443@2|Bacteria,2GMNN@201174|Actinobacteria,4D91S@85008|Micromonosporales	201174|Actinobacteria	O	Hsp70 protein	hscA	-	-	-	-	-	-	-	-	-	-	-	HSP70,PQQ_2
CMS3_k127_7195918_6	195250.CM001776_gene435	5.336e-06	58.0	COG0265@1|root,COG0265@2|Bacteria,1G0U4@1117|Cyanobacteria,1GYHE@1129|Synechococcus	1117|Cyanobacteria	O	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
CMS3_k127_7237066_2	886293.Sinac_5748	2.139e-42	174.0	COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,2IXD0@203682|Planctomycetes	203682|Planctomycetes	C	COG0437 Fe-S-cluster-containing hydrogenase components 1	-	-	-	-	-	-	-	-	-	-	-	-	DmsC,Fer4_11
CMS3_k127_7237066_0	868595.Desca_0835	3.147e-131	444.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,2601P@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CMS3_k127_7237066_1	1459636.NTE_01932	1.418e-82	293.0	COG2133@1|root,arCOG02796@2157|Archaea	1459636.NTE_01932|-	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	-
CMS3_k127_7237066_3	880073.Calab_0513	4.855e-36	141.0	2C3GN@1|root,31EWU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7238308_3	292459.STH885	3.083e-39	165.0	COG0500@1|root,COG2226@2|Bacteria,1TR7I@1239|Firmicutes,24FG4@186801|Clostridia	186801|Clostridia	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS3_k127_7238308_4	1274.HX89_08545	5.297e-25	122.0	COG0647@1|root,COG0647@2|Bacteria,2GK7V@201174|Actinobacteria,1ZVZ0@145357|Dermacoccaceae	201174|Actinobacteria	G	Belongs to the HAD-like hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
CMS3_k127_7238308_0	1201290.M902_1567	1.063e-135	441.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acyl-coa dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_7238308_1	1120971.AUCA01000015_gene294	5.135e-100	335.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4HA59@91061|Bacilli	91061|Bacilli	I	Dehydrogenase	hbd	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
CMS3_k127_7238308_2	1382306.JNIM01000001_gene268	2.078e-85	288.0	COG1024@1|root,COG1024@2|Bacteria,2G5JW@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
CMS3_k127_7240128_0	266117.Rxyl_2540	1.513e-209	680.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4CPJ8@84995|Rubrobacteria	84995|Rubrobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
CMS3_k127_7240128_1	1089550.ATTH01000001_gene2547	5.08e-159	522.0	COG1757@1|root,COG1757@2|Bacteria,4NHP9@976|Bacteroidetes,1FIXG@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
CMS3_k127_7240128_4	471870.BACINT_03124	2.584e-12	79.0	COG2819@1|root,COG2819@2|Bacteria,4NGJB@976|Bacteroidetes,2FR8R@200643|Bacteroidia,4AQA2@815|Bacteroidaceae	976|Bacteroidetes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS3_k127_7240128_3	696369.KI912183_gene1990	2.477e-40	164.0	COG1573@1|root,COG1573@2|Bacteria,1V267@1239|Firmicutes,24DFW@186801|Clostridia,261VB@186807|Peptococcaceae	186801|Clostridia	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS3_k127_7240128_2	1121374.KB891576_gene458	6.366e-42	172.0	COG2885@1|root,COG2885@2|Bacteria,1P1AB@1224|Proteobacteria,1RMCQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the ompA family	oprF	-	-	-	-	-	-	-	-	-	-	-	OmpA
CMS3_k127_7243804_3	1379698.RBG1_1C00001G0779	0.0006581	50.0	COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
CMS3_k127_7243804_1	1379698.RBG1_1C00001G0780	1.191e-123	411.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	ko:K00410,ko:K00412,ko:K02635,ko:K02637	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	-	-	ko00000,ko00001,ko00002,ko00194,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
CMS3_k127_7243804_2	1379698.RBG1_1C00001G0781	9.275e-38	149.0	COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria	2|Bacteria	C	Rieske [2Fe-2S] domain	petA	-	1.10.2.2,1.10.9.1	ko:K00411,ko:K02636,ko:K03886	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske,UCR_Fe-S_N
CMS3_k127_7243804_0	298653.Franean1_7227	3.58e-207	652.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4ESB0@85013|Frankiales	201174|Actinobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
CMS3_k127_7245479_1	926569.ANT_11490	1.998e-19	98.0	COG1807@1|root,COG1807@2|Bacteria,2G9HX@200795|Chloroflexi	200795|Chloroflexi	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7245479_0	644966.Tmar_0637	1.037e-29	133.0	COG0438@1|root,COG0438@2|Bacteria,1TSNT@1239|Firmicutes,248MH@186801|Clostridia,3WDTF@538999|Clostridiales incertae sedis	186801|Clostridia	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_7245479_2	216595.PFLU_1658	5.36e-06	54.0	COG0451@1|root,COG1898@1|root,COG0451@2|Bacteria,COG1898@2|Bacteria,1MXGB@1224|Proteobacteria,1RSK7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	COG0451 Nucleoside-diphosphate-sugar epimerases	fnlB	-	1.1.1.367	ko:K19068	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
CMS3_k127_7271690_0	1089553.Tph_c26180	1.046e-167	541.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,42EMJ@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
CMS3_k127_7271690_1	1125863.JAFN01000001_gene3405	1.648e-71	272.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
CMS3_k127_7271690_2	1125863.JAFN01000001_gene3407	2.255e-63	230.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42QNS@68525|delta/epsilon subdivisions,2WMSN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
CMS3_k127_7271690_3	521098.Aaci_2742	1.514e-26	121.0	COG3880@1|root,COG3880@2|Bacteria,1V6YM@1239|Firmicutes,4HH4R@91061|Bacilli,278EU@186823|Alicyclobacillaceae	91061|Bacilli	S	UvrB/uvrC motif	mcsA	GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
CMS3_k127_7271690_4	1123508.JH636445_gene6811	1.913e-06	59.0	COG3869@1|root,COG3869@2|Bacteria,2IXJG@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the specific phosphorylation of arginine residues in proteins	mcsB	-	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
CMS3_k127_7292070_2	357808.RoseRS_0459	1.291e-16	92.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
CMS3_k127_7292070_0	1123368.AUIS01000023_gene925	5.515e-111	370.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	antiporter	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS3_k127_7292070_1	1232410.KI421417_gene2711	3.832e-58	212.0	COG0730@1|root,COG0730@2|Bacteria,1R3ZH@1224|Proteobacteria,42W0W@68525|delta/epsilon subdivisions,2WSCE@28221|Deltaproteobacteria,43VGX@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS3_k127_7292477_3	379066.GAU_0002	8.634e-80	281.0	COG0592@1|root,COG0592@2|Bacteria,1ZT22@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_3
CMS3_k127_7292477_5	1120973.AQXL01000114_gene716	1.805e-54	206.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,4HA0W@91061|Bacilli,277VW@186823|Alicyclobacillaceae	91061|Bacilli	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
CMS3_k127_7292477_6	515635.Dtur_1548	1.823e-17	88.0	COG5512@1|root,COG5512@2|Bacteria	2|Bacteria	L	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
CMS3_k127_7292477_1	370438.PTH_0005	9.929e-269	841.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,260WQ@186807|Peptococcaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
CMS3_k127_7292477_0	404380.Gbem_0005	5.138e-315	986.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,43T5S@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CMS3_k127_7292477_4	880073.Calab_0942	3.141e-57	211.0	COG2344@1|root,COG2344@2|Bacteria,2NPI1@2323|unclassified Bacteria	2|Bacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
CMS3_k127_7292477_2	1122143.AUEG01000017_gene1911	5.759e-121	413.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4HBVV@91061|Bacilli,27F7B@186828|Carnobacteriaceae	91061|Bacilli	S	ABC transporter C-terminal domain	ydiF	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
CMS3_k127_7309616_0	1232410.KI421412_gene323	4.593e-123	413.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS3_k127_7309616_1	518766.Rmar_0734	5.735e-81	282.0	COG0569@1|root,COG0569@2|Bacteria,4NE31@976|Bacteroidetes,1FJEY@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS3_k127_731420_2	1121930.AQXG01000002_gene2242	7.129e-23	104.0	COG1239@1|root,COG1239@2|Bacteria,4NF1J@976|Bacteroidetes,1IQK5@117747|Sphingobacteriia	976|Bacteroidetes	H	Sigma-54 interaction domain	chlI	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Sigma54_activat
CMS3_k127_731420_0	1379698.RBG1_1C00001G1660	2.239e-122	407.0	COG4867@1|root,COG4867@2|Bacteria,2NQZ8@2323|unclassified Bacteria	2|Bacteria	S	von Willebrand factor (vWF) type A domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
CMS3_k127_731420_1	1122919.KB905616_gene200	1.294e-61	225.0	COG0477@1|root,COG2814@2|Bacteria,1TRDJ@1239|Firmicutes,4H9Q9@91061|Bacilli,26TUC@186822|Paenibacillaceae	91061|Bacilli	EGP	Multidrug transporter	mdtG	-	-	ko:K08161	-	-	-	-	ko00000,ko02000	2.A.1.2.20	-	-	MFS_1,MFS_1_like,Sugar_tr
CMS3_k127_7329369_0	593750.Metfor_1976	5.457e-47	188.0	COG2208@1|root,arCOG02362@1|root,arCOG02362@2157|Archaea,arCOG06893@2157|Archaea,2Y2MD@28890|Euryarchaeota	2157|Archaea	T	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE,dCache_1
CMS3_k127_7334806_0	1122921.KB898185_gene3633	1.626e-263	821.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,4H9NH@91061|Bacilli,26UV8@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
CMS3_k127_7334806_1	484770.UFO1_4404	6.855e-81	279.0	COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,4H301@909932|Negativicutes	909932|Negativicutes	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
CMS3_k127_7345971_1	243231.GSU2614	2.477e-106	367.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,42MYF@68525|delta/epsilon subdivisions,2WJE3@28221|Deltaproteobacteria,43UIB@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
CMS3_k127_7345971_0	697303.Thewi_1171	4.918e-209	675.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,42F3U@68295|Thermoanaerobacterales	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
CMS3_k127_7345971_2	768710.DesyoDRAFT_0858	9.552e-41	156.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia,2626H@186807|Peptococcaceae	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
CMS3_k127_7394789_0	309807.SRU_0982	1.634e-59	220.0	COG5505@1|root,COG5505@2|Bacteria,4NE2H@976|Bacteroidetes,1FJQG@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Protein of unknown function (DUF819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF819
CMS3_k127_7470949_0	1499967.BAYZ01000017_gene6221	3.446e-88	301.0	COG2148@1|root,COG2148@2|Bacteria,2NP0Q@2323|unclassified Bacteria	2|Bacteria	M	Bacterial sugar transferase	wcaJ	-	-	ko:K03606	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,CoA_binding_3
CMS3_k127_7470949_1	326427.Cagg_1177	2.371e-27	115.0	COG0438@1|root,COG0438@2|Bacteria,2G683@200795|Chloroflexi,374UN@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_7483111_1	1131269.AQVV01000018_gene1908	8.468e-27	117.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
CMS3_k127_7483111_0	330214.NIDE2199	3.147e-56	216.0	COG2206@1|root,COG2206@2|Bacteria,3J14V@40117|Nitrospirae	40117|Nitrospirae	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD
CMS3_k127_7483111_2	903818.KI912269_gene200	1.32e-07	62.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,MFS_1,TLC,cNMP_binding
CMS3_k127_7492320_0	1121859.KB890750_gene108	9.126e-47	185.0	COG2067@1|root,COG2067@2|Bacteria,4NRUP@976|Bacteroidetes	976|Bacteroidetes	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7492320_1	1191523.MROS_0956	1.466e-24	118.0	28PR2@1|root,2ZCCZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7508988_0	1120936.KB907215_gene3950	6.411e-32	144.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Big_2,CBM_25,Calx-beta,DUF4114,P_proprotein,Peptidase_S8,SBBP,SLH,VCBS
CMS3_k127_7515155_4	1430331.EP10_05385	1.441e-72	252.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,1WF0Q@129337|Geobacillus	91061|Bacilli	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
CMS3_k127_7515155_2	404589.Anae109_0662	1.164e-120	401.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,42PCD@68525|delta/epsilon subdivisions,2WKGQ@28221|Deltaproteobacteria,2YU9M@29|Myxococcales	28221|Deltaproteobacteria	F	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis	pdp	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
CMS3_k127_7515155_3	266117.Rxyl_2923	2.692e-79	286.0	COG0506@1|root,COG0506@2|Bacteria,2GJTK@201174|Actinobacteria,4CQPH@84995|Rubrobacteria	84995|Rubrobacteria	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
CMS3_k127_7515155_0	1379698.RBG1_1C00001G1562	2.004e-162	541.0	COG5009@1|root,COG5009@2|Bacteria,2NS4K@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase	mrcA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
CMS3_k127_7515155_1	639282.DEFDS_0113	7.996e-143	469.0	COG0162@1|root,COG0162@2|Bacteria,2GENZ@200930|Deferribacteres	200930|Deferribacteres	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
CMS3_k127_7515155_5	1380408.AVGH01000044_gene1352	3.391e-23	109.0	2DSQW@1|root,33H3S@2|Bacteria,1VP4J@1239|Firmicutes,4HSVH@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7515486_2	1244869.H261_03128	2.94e-66	228.0	COG1924@1|root,COG1924@2|Bacteria,1R411@1224|Proteobacteria,2U1DN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Benzoyl-CoA reductase subunit	-	-	1.3.7.8	ko:K04114	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	BcrAD_BadFG
CMS3_k127_7515486_0	1232410.KI421421_gene3273	7.719e-87	301.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42PM0@68525|delta/epsilon subdivisions,2X5NK@28221|Deltaproteobacteria,43W2S@69541|Desulfuromonadales	68525|delta/epsilon subdivisions	I	BadF/BadG/BcrA/BcrD ATPase family	hgdC	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
CMS3_k127_7515486_3	1125863.JAFN01000001_gene2436	5.793e-30	130.0	COG0454@1|root,COG0456@2|Bacteria,1N43K@1224|Proteobacteria,42VN3@68525|delta/epsilon subdivisions,2WRDJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS3_k127_7515486_1	1232437.KL662043_gene2235	1.471e-82	296.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,42Z5J@68525|delta/epsilon subdivisions,2X7Z6@28221|Deltaproteobacteria,2MMYR@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
CMS3_k127_7515486_4	1121459.AQXE01000007_gene717	9.329e-24	114.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42PHH@68525|delta/epsilon subdivisions,2WV9C@28221|Deltaproteobacteria,2M8TF@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_9,Response_reg
CMS3_k127_7520591_2	667014.Thein_0261	2.86e-24	113.0	COG0204@1|root,COG0204@2|Bacteria,2GH4C@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS3_k127_7520591_1	1265505.ATUG01000002_gene1414	1.37e-48	186.0	COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,42RSB@68525|delta/epsilon subdivisions,2X6V6@28221|Deltaproteobacteria,2MMG6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
CMS3_k127_7520591_0	378806.STAUR_2302	7.28e-82	295.0	COG0204@1|root,COG0236@1|root,COG1022@1|root,COG3320@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG1022@2|Bacteria,COG3320@2|Bacteria,1MU4D@1224|Proteobacteria,42NHQ@68525|delta/epsilon subdivisions,2WJZ5@28221|Deltaproteobacteria,2YU6Q@29|Myxococcales	28221|Deltaproteobacteria	IQ	Male sterility protein	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,NAD_binding_4,PP-binding,Sterile
CMS3_k127_7545169_1	1173028.ANKO01000116_gene5724	0.0002141	51.0	COG0546@1|root,COG0546@2|Bacteria,1G6AW@1117|Cyanobacteria,1HCZI@1150|Oscillatoriales	1117|Cyanobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
CMS3_k127_7545169_0	290397.Adeh_3951	5.39e-118	392.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,2YUI6@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Thioredoxin
CMS3_k127_7551841_2	880073.Calab_0513	9.536e-41	169.0	2C3GN@1|root,31EWU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7551841_3	765420.OSCT_1929	2.554e-24	119.0	2E65M@1|root,330UB@2|Bacteria	2|Bacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
CMS3_k127_7551841_0	1124780.ANNU01000072_gene1068	9.827e-268	849.0	COG2866@1|root,COG2866@2|Bacteria,4NEJA@976|Bacteroidetes,47KZ0@768503|Cytophagia	976|Bacteroidetes	E	PFAM Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
CMS3_k127_7551841_1	886293.Sinac_2956	9.117e-46	180.0	COG0859@1|root,COG0859@2|Bacteria,2J1VG@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
CMS3_k127_7581583_1	880073.Calab_2398	5.74e-25	118.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7581583_0	880073.Calab_2399	9.775e-111	392.0	COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria	2|Bacteria	P	COGs COG1629 Outer membrane receptor protein mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
CMS3_k127_7581583_2	309807.SRU_1917	4.336e-10	70.0	COG2374@1|root,COG2374@2|Bacteria,4PF3F@976|Bacteroidetes,1FK2U@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7584786_2	1415780.JPOG01000001_gene1473	8.782e-23	115.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1X3DM@135614|Xanthomonadales	135614|Xanthomonadales	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
CMS3_k127_7584786_1	1123368.AUIS01000016_gene2521	2.504e-32	146.0	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,1SACF@1236|Gammaproteobacteria,2NBVJ@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
CMS3_k127_7584786_0	861299.J421_3224	9.851e-76	267.0	COG0763@1|root,COG0763@2|Bacteria,1ZTAD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
CMS3_k127_7584786_3	1396141.BATP01000007_gene5602	1.741e-06	53.0	COG0673@1|root,COG0673@2|Bacteria,46SAE@74201|Verrucomicrobia,2IU1W@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS3_k127_7592207_4	459349.CLOAM0871	1.245e-06	57.0	COG2843@1|root,COG3291@1|root,COG2843@2|Bacteria,COG3291@2|Bacteria,2NPJI@2323|unclassified Bacteria	2|Bacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap,PKD,Peptidase_M15_4
CMS3_k127_7592207_1	1519464.HY22_01020	1.831e-28	132.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
CMS3_k127_7592207_2	1267533.KB906736_gene1246	6.076e-17	86.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
CMS3_k127_7592207_0	234267.Acid_7572	3.67e-29	126.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
CMS3_k127_7592207_3	1196323.ALKF01000149_gene1456	8.303e-15	78.0	COG1277@1|root,COG1277@2|Bacteria,1UP3Z@1239|Firmicutes,4IUZZ@91061|Bacilli,276YX@186822|Paenibacillaceae	2|Bacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7602293_2	665956.HMPREF1032_02389	4.621e-33	135.0	COG0211@1|root,COG0211@2|Bacteria,1V6HW@1239|Firmicutes,24N3D@186801|Clostridia,3WJU0@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
CMS3_k127_7602293_3	1121351.AUAP01000013_gene1107	2.855e-25	108.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2VSHZ@28216|Betaproteobacteria,2KRDC@206351|Neisseriales	206351|Neisseriales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
CMS3_k127_7602293_0	379066.GAU_1700	5.975e-149	492.0	COG1530@1|root,COG1530@2|Bacteria,1ZSZS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribonuclease E/G family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
CMS3_k127_7602293_1	1379698.RBG1_1C00001G1211	1.486e-88	299.0	COG0034@1|root,COG0034@2|Bacteria,2NNSY@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iSB619.SA_RS05225	GATase_6,GATase_7,Pribosyltran
CMS3_k127_7606965_0	443143.GM18_4316	2.172e-39	171.0	COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,1MU3S@1224|Proteobacteria,42Q3Z@68525|delta/epsilon subdivisions,2WJPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the peptidase S8 family	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Big_2,CUB,He_PIG,Peptidase_S8
CMS3_k127_7606965_1	1379698.RBG1_1C00001G0490	1.379e-20	98.0	COG2067@1|root,COG2067@2|Bacteria,2NR8A@2323|unclassified Bacteria	2|Bacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_762181_4	1434929.X946_3758	1.619e-10	61.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2VIWI@28216|Betaproteobacteria,1K590@119060|Burkholderiaceae	28216|Betaproteobacteria	S	penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
CMS3_k127_762181_5	742740.HMPREF9474_04453	1.767e-07	58.0	COG2227@1|root,COG2227@2|Bacteria,1VSM2@1239|Firmicutes,24G5E@186801|Clostridia	186801|Clostridia	H	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS3_k127_762181_1	63737.Npun_F5304	3.591e-63	240.0	COG1011@1|root,COG1011@2|Bacteria,1G4JI@1117|Cyanobacteria	1117|Cyanobacteria	S	dehalogenase, type II	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS3_k127_762181_0	1499967.BAYZ01000048_gene2706	1.803e-103	349.0	COG3616@1|root,COG3616@2|Bacteria,2NPWK@2323|unclassified Bacteria	2|Bacteria	E	Putative serine dehydratase domain	-	-	4.3.1.27	ko:K20757	-	-	-	-	ko00000,ko01000	-	-	-	Ala_racemase_N,D-ser_dehydrat
CMS3_k127_762181_2	237368.SCABRO_00828	5.213e-19	87.0	COG2036@1|root,COG2036@2|Bacteria	2|Bacteria	B	protein heterodimerization activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7630336_0	1207063.P24_06132	1.639e-248	778.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria,2JPZX@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0488 ATPase components of ABC transporters with duplicated ATPase domains	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
CMS3_k127_7630336_2	1183438.GKIL_2126	7.269e-13	78.0	COG1266@1|root,COG1266@2|Bacteria,1GFE4@1117|Cyanobacteria	1117|Cyanobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
CMS3_k127_7630336_1	926560.KE387027_gene665	3.215e-75	261.0	28JJ5@1|root,2Z9C9@2|Bacteria,1WJSQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	infection protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_7631375_2	990285.RGCCGE502_16355	7.585e-28	127.0	COG2370@1|root,COG2370@2|Bacteria,1PPXD@1224|Proteobacteria,2V2C6@28211|Alphaproteobacteria,4BI58@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ
CMS3_k127_7631375_0	395492.Rleg2_5110	1.462e-66	235.0	COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2UA0Y@28211|Alphaproteobacteria,4B7VB@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	hupE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
CMS3_k127_7631375_1	585423.KR49_03395	5.371e-50	180.0	COG2370@1|root,COG2370@2|Bacteria,1G65K@1117|Cyanobacteria,1GZTA@1129|Synechococcus	1117|Cyanobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
CMS3_k127_7633888_1	880073.Calab_1769	0.0008007	44.0	COG5563@1|root,COG5563@2|Bacteria	2|Bacteria	-	-	CP_1072	-	-	-	-	-	-	-	-	-	-	-	Autotransporter
CMS3_k127_7633888_0	502025.Hoch_0068	9.007e-32	145.0	COG3227@1|root,COG3227@2|Bacteria,1Q6DC@1224|Proteobacteria,432XR@68525|delta/epsilon subdivisions,2WYJ7@28221|Deltaproteobacteria,2Z34H@29|Myxococcales	28221|Deltaproteobacteria	E	Zinc metalloprotease (Elastase)	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_788268_1	65071.PYU1_T010871	0.0001598	51.0	2CZB7@1|root,2S9GS@2759|Eukaryota,1MHX1@121069|Pythiales	121069|Pythiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_788268_0	574087.Acear_2323	9.586e-109	364.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,3WAAB@53433|Halanaerobiales	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
CMS3_k127_79021_0	319224.Sputcn32_2196	2.785e-163	528.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,2QA1K@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Patched family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS3_k127_79021_1	743720.Psefu_1831	1.018e-70	254.0	COG4447@1|root,COG4447@2|Bacteria,1RCNG@1224|Proteobacteria,1S1N2@1236|Gammaproteobacteria,1YZN6@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Photosynthesis system II assembly factor YCF48	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
CMS3_k127_79021_2	452637.Oter_3166	8.515e-15	75.0	28H52@1|root,2Z7HQ@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
CMS3_k127_799614_0	686340.Metal_1558	9.966e-220	689.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1XEUJ@135618|Methylococcales	135618|Methylococcales	C	Isocitrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Iso_dh
CMS3_k127_799614_2	234267.Acid_3676	1.026e-45	181.0	COG0231@1|root,COG0231@2|Bacteria,3Y373@57723|Acidobacteria	57723|Acidobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	-	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
CMS3_k127_799614_3	880073.Calab_2082	8.788e-25	123.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF4114,DUF4157
CMS3_k127_799614_4	222534.KB893671_gene3328	8.65e-22	113.0	COG1073@1|root,COG1520@1|root,COG1073@2|Bacteria,COG1520@2|Bacteria,2IJK1@201174|Actinobacteria	201174|Actinobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DUF5050
CMS3_k127_799614_1	886293.Sinac_4686	5.032e-48	179.0	COG0229@1|root,COG0229@2|Bacteria,2IZVK@203682|Planctomycetes	203682|Planctomycetes	O	peptide-methionine (R)-S-oxide reductase	-	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
CMS3_k127_799614_5	1117379.BABA_12835	6.444e-11	65.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,4HA0E@91061|Bacilli,1ZDF1@1386|Bacillus	91061|Bacilli	E	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
CMS3_k127_809075_1	1121104.AQXH01000001_gene1619	3.631e-32	131.0	COG0160@1|root,COG0160@2|Bacteria,4NGPB@976|Bacteroidetes,1IP2R@117747|Sphingobacteriia	976|Bacteroidetes	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lat	-	2.6.1.36	ko:K03918	ko01100,map01100	-	R00457	RC00006,RC00062	ko00000,ko01000,ko01007	-	-	-	Aminotran_3
CMS3_k127_809075_0	1125863.JAFN01000001_gene1590	5.685e-129	437.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	SMART Nucleotide binding protein, PINc	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
CMS3_k127_809075_2	518766.Rmar_1620	9.944e-23	113.0	COG1762@1|root,COG1762@2|Bacteria,4NY7D@976|Bacteroidetes,1FJF6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	2.7.1.202	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
CMS3_k127_810412_5	1267533.KB906733_gene3096	1.223e-07	60.0	COG1215@1|root,COG1215@2|Bacteria,3Y31I@57723|Acidobacteria,2JIKW@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
CMS3_k127_810412_4	118166.JH976537_gene307	2.008e-39	163.0	COG0463@1|root,COG0463@2|Bacteria,1G0TT@1117|Cyanobacteria,1H9MU@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_810412_3	102129.Lepto7375DRAFT_1220	2.857e-41	153.0	COG1960@1|root,COG1960@2|Bacteria,1G4UB@1117|Cyanobacteria	1117|Cyanobacteria	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_810412_1	313596.RB2501_08725	1.863e-68	257.0	COG1215@1|root,COG1215@2|Bacteria,4NFM1@976|Bacteroidetes,1HX0G@117743|Flavobacteriia	976|Bacteroidetes	M	Pfam Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS3_k127_810412_2	1089550.ATTH01000001_gene1359	3.827e-46	189.0	COG0398@1|root,COG0398@2|Bacteria,4NIT2@976|Bacteroidetes,1FK2Q@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
CMS3_k127_810412_0	330214.NIDE0312	1.07e-298	934.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,3J0XT@40117|Nitrospirae	40117|Nitrospirae	E	Glycine cleavage system P-protein	-	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	-
CMS3_k127_811103_0	251221.35214444	4.804e-204	657.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	dpp4	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,PD40,Peptidase_S9
CMS3_k127_817420_2	344747.PM8797T_16735	6.096e-11	69.0	COG0501@1|root,COG0501@2|Bacteria,2IXM0@203682|Planctomycetes	203682|Planctomycetes	O	Zn-dependent protease with chaperone function	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CMS3_k127_817420_0	247490.KSU1_D0395	1.317e-75	266.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS3_k127_817420_1	1120956.JHZK01000026_gene763	7.215e-71	254.0	COG0428@1|root,COG0428@2|Bacteria,1MWEZ@1224|Proteobacteria,2TTF1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	divalent heavy-metal cations transporter	zupT	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
CMS3_k127_818539_0	204669.Acid345_0343	1.269e-84	287.0	COG1085@1|root,COG1085@2|Bacteria,3Y41K@57723|Acidobacteria,2JMKJ@204432|Acidobacteriia	204432|Acidobacteriia	C	Domain of unknown function (DUF4921)	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C
CMS3_k127_818539_2	485918.Cpin_7286	2.391e-07	60.0	2AFPJ@1|root,315RB@2|Bacteria,4PJWT@976|Bacteroidetes,1IUP5@117747|Sphingobacteriia	976|Bacteroidetes	S	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
CMS3_k127_818539_1	1121456.ATVA01000012_gene2804	2.099e-70	253.0	COG0438@1|root,COG0438@2|Bacteria,1MUYN@1224|Proteobacteria,43F2S@68525|delta/epsilon subdivisions,2X35V@28221|Deltaproteobacteria,2ME5E@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS3_k127_819481_1	234267.Acid_0392	1.162e-160	522.0	COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria	57723|Acidobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
CMS3_k127_819481_4	234267.Acid_0393	4.787e-32	145.0	COG1913@1|root,COG1913@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
CMS3_k127_819481_0	234267.Acid_0394	8.651e-211	663.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02481,ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_819481_3	234267.Acid_0398	1.176e-50	193.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H,Response_reg
CMS3_k127_819481_2	234267.Acid_0399	1.205e-96	321.0	COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria	2|Bacteria	C	Polysulphide reductase, NrfD	qrcD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
CMS3_k127_829953_0	448385.sce4763	3.593e-191	608.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2X37C@28221|Deltaproteobacteria,2YUQZ@29|Myxococcales	28221|Deltaproteobacteria	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
CMS3_k127_829953_1	234267.Acid_4431	5.294e-168	575.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
CMS3_k127_83543_0	316274.Haur_4503	0.000189	51.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS3_k127_843592_2	696747.NIES39_O05180	2.051e-43	163.0	COG0515@1|root,COG1520@1|root,COG0515@2|Bacteria,COG1520@2|Bacteria,1G7CP@1117|Cyanobacteria	1117|Cyanobacteria	KLT	PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
CMS3_k127_843592_3	404589.Anae109_1755	6.228e-32	142.0	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,43C89@68525|delta/epsilon subdivisions,2X7IN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CMS3_k127_843592_0	1379698.RBG1_1C00001G1627	1.666e-231	738.0	COG0465@1|root,COG0465@2|Bacteria,2NNQ5@2323|unclassified Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CMS3_k127_843592_1	1259795.ARJK01000003_gene741	7.34e-57	208.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,42G9G@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
CMS3_k127_843592_4	357808.RoseRS_0321	2.496e-11	74.0	COG0037@1|root,COG0634@1|root,COG0037@2|Bacteria,COG0634@2|Bacteria,2G6AD@200795|Chloroflexi,374VQ@32061|Chloroflexia	32061|Chloroflexia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	2.4.2.8,6.3.4.19	ko:K00760,ko:K04075	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,Pribosyltran,TilS,TilS_C
CMS3_k127_903614_2	643562.Daes_2668	6.517e-29	127.0	COG0644@1|root,COG1145@1|root,COG0644@2|Bacteria,COG1145@2|Bacteria,1MVU6@1224|Proteobacteria,42PTE@68525|delta/epsilon subdivisions,2WKRZ@28221|Deltaproteobacteria,2MA78@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein-ubiquinone	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO
CMS3_k127_903614_0	234267.Acid_0094	0.0	1030.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	fadE23	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
CMS3_k127_903614_1	1226325.HMPREF1548_04171	3.629e-51	197.0	COG0535@1|root,COG0535@2|Bacteria,1UXWS@1239|Firmicutes,247NG@186801|Clostridia,36PAN@31979|Clostridiaceae	186801|Clostridia	C	Iron-sulfur cluster-binding domain	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS3_k127_903614_3	479434.Sthe_2317	1.141e-21	98.0	COG0154@1|root,COG0154@2|Bacteria,2G7S4@200795|Chloroflexi,27YVX@189775|Thermomicrobia	189775|Thermomicrobia	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
CMS3_k127_908030_2	1408473.JHXO01000006_gene1212	2.671e-39	152.0	COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,2FMPG@200643|Bacteroidia	976|Bacteroidetes	T	acetoacetate metabolism regulatory protein AtoC K07714	ntrX	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS3_k127_908030_0	688269.Theth_1776	6.512e-72	256.0	COG0820@1|root,COG0820@2|Bacteria,2GC5D@200918|Thermotogae	200918|Thermotogae	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
CMS3_k127_908030_1	290397.Adeh_3342	2.261e-59	232.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2YUYF@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
CMS3_k127_931779_1	1304874.JAFY01000007_gene1895	8.059e-33	139.0	COG0358@1|root,COG0358@2|Bacteria,3TAFM@508458|Synergistetes	508458|Synergistetes	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_2,Toprim_4,Toprim_N,zf-CHC2
CMS3_k127_931779_0	926569.ANT_30000	6.611e-82	288.0	COG1193@1|root,COG1193@2|Bacteria,2G5R8@200795|Chloroflexi	200795|Chloroflexi	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_III,MutS_V,Smr
CMS3_k127_933739_1	118166.JH976537_gene853	1.388e-36	149.0	COG0438@1|root,COG0438@2|Bacteria,1G2QJ@1117|Cyanobacteria,1H8BQ@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS3_k127_933739_0	309801.trd_0916	1.144e-81	282.0	COG0451@1|root,COG0451@2|Bacteria,2GBGX@200795|Chloroflexi,27Y3C@189775|Thermomicrobia	189775|Thermomicrobia	M	Polysaccharide biosynthesis protein	-	-	1.1.1.281	ko:K15856	ko00051,ko00520,map00051,map00520	-	R03397,R03399	RC00182	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
CMS3_k127_933739_2	1041930.Mtc_0628	8.711e-12	66.0	COG1089@1|root,arCOG01373@2157|Archaea,2XUVY@28890|Euryarchaeota,2N9AM@224756|Methanomicrobia	224756|Methanomicrobia	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
CMS3_k127_938118_3	1118054.CAGW01000091_gene3551	1.211e-47	173.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,4H9S9@91061|Bacilli,26QRT@186822|Paenibacillaceae	91061|Bacilli	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
CMS3_k127_938118_6	398767.Glov_1912	4.341e-34	132.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,42TRU@68525|delta/epsilon subdivisions,2WPZK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
CMS3_k127_938118_8	573370.DMR_12420	1.456e-13	75.0	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,42WXD@68525|delta/epsilon subdivisions,2WSYK@28221|Deltaproteobacteria,2MDXC@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
CMS3_k127_938118_4	646529.Desaci_0515	3.155e-47	173.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,261QX@186807|Peptococcaceae	186801|Clostridia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
CMS3_k127_938118_1	266940.Krad_0714	1.694e-52	188.0	COG0100@1|root,COG0100@2|Bacteria,2IFFC@201174|Actinobacteria	201174|Actinobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
CMS3_k127_938118_7	1089553.Tph_c25580	1.098e-20	93.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,42ENH@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
CMS3_k127_938118_2	1125863.JAFN01000001_gene3321	1.12e-47	175.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
CMS3_k127_938118_0	1379698.RBG1_1C00001G1568	6.396e-104	347.0	COG0202@1|root,COG0202@2|Bacteria,2NNQQ@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
CMS3_k127_938118_5	1121403.AUCV01000025_gene2272	2.573e-40	156.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,42SBD@68525|delta/epsilon subdivisions,2WP9P@28221|Deltaproteobacteria,2MKCX@213118|Desulfobacterales	28221|Deltaproteobacteria	J	PFAM ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
CMS3_k127_960940_2	289376.THEYE_A0044	7.131e-64	227.0	COG1624@1|root,COG1624@2|Bacteria,3J0XP@40117|Nitrospirae	40117|Nitrospirae	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
CMS3_k127_960940_4	517418.Ctha_0250	4.534e-07	57.0	COG1366@1|root,COG1366@2|Bacteria,1FFJ9@1090|Chlorobi	1090|Chlorobi	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS
CMS3_k127_960940_3	696369.KI912183_gene1026	5.109e-47	171.0	COG0599@1|root,COG0599@2|Bacteria,1UWS5@1239|Firmicutes,24J92@186801|Clostridia,26232@186807|Peptococcaceae	186801|Clostridia	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS3_k127_960940_0	330214.NIDE3701	2.52e-131	428.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
CMS3_k127_960940_1	391625.PPSIR1_33119	8.295e-73	254.0	COG0778@1|root,COG0778@2|Bacteria,1PEI0@1224|Proteobacteria,43A62@68525|delta/epsilon subdivisions,2X9UY@28221|Deltaproteobacteria,2Z2MI@29|Myxococcales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	1.13.11.79	ko:K04719	ko00740,ko01100,map00740,map01100	-	R09083	RC00435,RC02413	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
CMS3_k127_960940_5	360911.EAT1b_2044	1.358e-06	56.0	28NT3@1|root,2ZBRV@2|Bacteria,1V1C2@1239|Firmicutes,4HFYQ@91061|Bacilli	91061|Bacilli	S	YwiC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YwiC
CMS3_k127_962088_1	1379698.RBG1_1C00001G1491	2.789e-40	161.0	COG1420@1|root,COG1420@2|Bacteria,2NPAK@2323|unclassified Bacteria	2|Bacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA,HrcA_DNA-bdg
CMS3_k127_962088_2	1298598.JCM21714_74	2.157e-28	122.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli,470HZ@74385|Gracilibacillus	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
CMS3_k127_962088_0	1379698.RBG1_1C00001G1489	9.985e-270	840.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
CMS3_k127_978522_0	290397.Adeh_3929	6.181e-116	383.0	COG0266@1|root,COG0266@2|Bacteria,1MVHK@1224|Proteobacteria,43791@68525|delta/epsilon subdivisions,2X9X0@28221|Deltaproteobacteria,2YZTI@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the FPG family	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
CMS3_k127_978522_1	1242864.D187_007363	3.333e-101	355.0	COG1807@1|root,COG1807@2|Bacteria,1NPGH@1224|Proteobacteria,4322Q@68525|delta/epsilon subdivisions,2WWF0@28221|Deltaproteobacteria,2YVRQ@29|Myxococcales	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_989650_3	518766.Rmar_1887	2.057e-14	73.0	COG2442@1|root,COG2442@2|Bacteria,4P9SX@976|Bacteroidetes,1FJP2@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
CMS3_k127_989650_2	518766.Rmar_1888	6.695e-25	107.0	COG4634@1|root,COG4634@2|Bacteria,4NUV6@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS3_k127_989650_0	1089550.ATTH01000001_gene1831	3.854e-63	241.0	COG0515@1|root,COG0515@2|Bacteria,4NPN9@976|Bacteroidetes,1FJI6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	NERD,Pkinase,TPR_12,TPR_8
CMS3_k127_989650_1	861299.J421_4375	2.593e-40	158.0	COG1595@1|root,COG1595@2|Bacteria,1ZTNR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS3_k127_989650_4	1384056.N787_04780	2.679e-05	58.0	2CKCT@1|root,32SC5@2|Bacteria,1N1BJ@1224|Proteobacteria,1T6U5@1236|Gammaproteobacteria,1X85I@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
## 2275 queries scanned
## Total time (seconds): 353.1258451938629
## Rate: 6.44 q/s