## Sat Dec 13 07:52:59 2025
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/qs/new/DEZH2_bin.2.fa -m mmseqs --itype genome -o DEZH2_bin.2 --output_dir /data/result/bins/wyx/egg/DEZH2_bin.2 --cpu 32
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
DEZH2_k127_10004880_1	251229.Chro_0663	1.546e-78	273.0	COG0313@1|root,COG0313@2|Bacteria,1G0IF@1117|Cyanobacteria,3VHX0@52604|Pleurocapsales	1117|Cyanobacteria	J	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
DEZH2_k127_10004880_4	1410624.JNKK01000002_gene945	2.907e-40	162.0	COG4123@1|root,COG4123@2|Bacteria,1TQ25@1239|Firmicutes,249UH@186801|Clostridia,27ID2@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Methyltransferase small domain	yfiC	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS,Methyltransf_31
DEZH2_k127_10004880_5	1123075.AUDP01000013_gene3069	4.544e-21	95.0	COG1148@1|root,COG1148@2|Bacteria,1UI0M@1239|Firmicutes,25E99@186801|Clostridia,3WMHU@541000|Ruminococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
DEZH2_k127_10004880_0	398512.JQKC01000029_gene4300	3.28e-105	350.0	COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,247Q6@186801|Clostridia,3WHA4@541000|Ruminococcaceae	186801|Clostridia	S	PSP1 C-terminal domain protein	yaaT	-	-	-	-	-	-	-	-	-	-	-	PSP1
DEZH2_k127_10004880_2	1392491.JIAE01000001_gene2336	4.087e-48	186.0	COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia,3WI7S@541000|Ruminococcaceae	186801|Clostridia	L	DNA polymerase III	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
DEZH2_k127_10004880_3	699246.HMPREF0868_1014	1.99e-44	164.0	COG3870@1|root,COG3870@2|Bacteria,1V6NI@1239|Firmicutes,24N37@186801|Clostridia	186801|Clostridia	S	protein conserved in bacteria	yaaQ	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
DEZH2_k127_10042875_1	411471.SUBVAR_07274	7.428e-40	155.0	COG3250@1|root,COG3250@2|Bacteria,1TQAM@1239|Firmicutes,248XS@186801|Clostridia,3WI0J@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
DEZH2_k127_10042875_0	931626.Awo_c22460	6.159e-123	400.0	COG1230@1|root,COG1230@2|Bacteria,1TR92@1239|Firmicutes,24AXN@186801|Clostridia	186801|Clostridia	P	cation diffusion facilitator family transporter	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux,ZT_dimer
DEZH2_k127_10042875_2	1410638.JHXJ01000006_gene2598	2.174e-18	90.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,3WGHX@541000|Ruminococcaceae	186801|Clostridia	S	ABC transporter	-	-	-	ko:K06158,ko:K19350	ko02010,map02010	-	-	-	ko00000,ko00001,ko01504,ko02000,ko03012	3.A.1.121	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
DEZH2_k127_10050101_2	1121335.Clst_1371	1.404e-66	237.0	COG1232@1|root,COG1232@2|Bacteria,1UQZD@1239|Firmicutes,24VCQ@186801|Clostridia,3WMB9@541000|Ruminococcaceae	186801|Clostridia	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
DEZH2_k127_10050101_0	1392491.JIAE01000001_gene625	2.441e-145	492.0	COG5427@1|root,COG5427@2|Bacteria,1UY7V@1239|Firmicutes,24BA0@186801|Clostridia,3WHM2@541000|Ruminococcaceae	186801|Clostridia	S	Uncharacterized membrane protein (DUF2298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298
DEZH2_k127_10050101_1	699246.HMPREF0868_1345	1.83e-80	286.0	COG0631@1|root,COG1388@1|root,COG0631@2|Bacteria,COG1388@2|Bacteria,1VW2C@1239|Firmicutes,251FU@186801|Clostridia	186801|Clostridia	T	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10050101_3	1121335.Clst_1563	9.182e-60	224.0	COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,3WGBR@541000|Ruminococcaceae	186801|Clostridia	J	tRNA nucleotidyltransferase poly(A) polymerase	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
DEZH2_k127_10058816_3	1392491.JIAE01000001_gene1806	5.769e-06	48.0	COG4260@1|root,COG4260@2|Bacteria,1TRYU@1239|Firmicutes,24901@186801|Clostridia,3WHZY@541000|Ruminococcaceae	186801|Clostridia	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,SHOCT
DEZH2_k127_10058816_2	537013.CLOSTMETH_03677	5.732e-07	51.0	COG4260@1|root,COG4260@2|Bacteria,1TRYU@1239|Firmicutes,24901@186801|Clostridia,3WHZY@541000|Ruminococcaceae	186801|Clostridia	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1
DEZH2_k127_10058816_0	994573.T472_0201075	1.098e-151	487.0	COG1645@1|root,COG1645@2|Bacteria,1TRYG@1239|Firmicutes,25F3V@186801|Clostridia,36UYV@31979|Clostridiaceae	186801|Clostridia	S	bacterial-type flagellum-dependent swarming motility	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10058816_1	994573.T472_0201070	9.217e-44	166.0	COG1512@1|root,COG1512@2|Bacteria,1V8N5@1239|Firmicutes,24H2W@186801|Clostridia,36IYA@31979|Clostridiaceae	186801|Clostridia	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
DEZH2_k127_10059916_4	500633.CLOHIR_01198	2.265e-50	186.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,25QIE@186804|Peptostreptococcaceae	186801|Clostridia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
DEZH2_k127_10059916_3	1408422.JHYF01000001_gene2762	6.78e-62	215.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,36I0X@31979|Clostridiaceae	186801|Clostridia	C	FeS cluster assembly scaffold protein NifU	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
DEZH2_k127_10059916_1	203119.Cthe_0720	9.597e-155	498.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,3WG87@541000|Ruminococcaceae	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
DEZH2_k127_10059916_0	203119.Cthe_0617	2.42e-192	609.0	COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,247X2@186801|Clostridia,3WGT0@541000|Ruminococcaceae	186801|Clostridia	L	ATPase, AAA family	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
DEZH2_k127_10059916_2	696281.Desru_3700	3.192e-87	291.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,2609R@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
DEZH2_k127_10077118_2	1121335.Clst_0621	8.537e-103	341.0	COG4806@1|root,COG4806@2|Bacteria,1TS42@1239|Firmicutes,2487G@186801|Clostridia,3WN5C@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the rhamnose isomerase family	rhaA	-	5.3.1.14	ko:K01813	ko00051,ko01120,map00051,map01120	-	R02437	RC00434	ko00000,ko00001,ko01000	-	-	-	RhaA
DEZH2_k127_10077118_1	1304880.JAGB01000002_gene1534	1.749e-157	509.0	COG0613@1|root,COG0613@2|Bacteria,1TSQJ@1239|Firmicutes,24EIM@186801|Clostridia	186801|Clostridia	S	PHP domain	-	-	-	-	-	-	-	-	-	-	-	-	PHP
DEZH2_k127_10077118_0	742725.HMPREF9450_01254	7.801e-312	965.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE4N@976|Bacteroidetes,2FQUA@200643|Bacteroidia	976|Bacteroidetes	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
DEZH2_k127_10096470_2	394503.Ccel_3202	3.105e-15	77.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,36EEP@31979|Clostridiaceae	186801|Clostridia	HP	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
DEZH2_k127_10096470_0	755732.Fluta_3445	7.857e-36	151.0	COG2153@1|root,COG2153@2|Bacteria,4NQPR@976|Bacteroidetes,1I23R@117743|Flavobacteriia,2PB3E@246874|Cryomorphaceae	976|Bacteroidetes	S	Acetyltransferase (GNAT) domain	elaA	-	-	ko:K02348	-	-	-	-	ko00000	-	-	-	Acetyltransf_10
DEZH2_k127_10096470_1	645991.Sgly_2780	2.72e-24	106.0	COG2247@1|root,COG2247@2|Bacteria,1TPEQ@1239|Firmicutes,24C0K@186801|Clostridia	186801|Clostridia	M	Putative cell wall binding repeat 2	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2
DEZH2_k127_10100825_4	476272.RUMHYD_00451	3.338e-19	94.0	COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia	186801|Clostridia	C	PFAM Phosphate acetyl butaryl transferase	-	-	2.3.1.19	ko:K00634	ko00650,ko01100,map00650,map01100	-	R01174	RC00004,RC02816	ko00000,ko00001,ko01000	-	-	-	PTA_PTB
DEZH2_k127_10100825_0	1297617.JPJD01000050_gene1939	5.242e-96	324.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia,2696S@186813|unclassified Clostridiales	186801|Clostridia	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
DEZH2_k127_10100825_2	656519.Halsa_0174	4.152e-67	244.0	COG0006@1|root,COG0006@2|Bacteria,1VCQW@1239|Firmicutes,24YZH@186801|Clostridia	186801|Clostridia	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
DEZH2_k127_10100825_1	903818.KI912268_gene2107	3.262e-84	286.0	COG1028@1|root,COG1028@2|Bacteria,3Y3CD@57723|Acidobacteria	57723|Acidobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
DEZH2_k127_10100825_3	1195236.CTER_4904	1.19e-63	222.0	COG0697@1|root,COG0697@2|Bacteria,1TPST@1239|Firmicutes,248K5@186801|Clostridia,3WHTX@541000|Ruminococcaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DEZH2_k127_10114429_2	1321778.HMPREF1982_00916	2.025e-09	60.0	COG3764@1|root,COG3764@2|Bacteria,1UN9R@1239|Firmicutes,24CEQ@186801|Clostridia,269Q1@186813|unclassified Clostridiales	186801|Clostridia	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
DEZH2_k127_10114429_1	1268072.PSAB_19050	7.616e-56	207.0	COG0667@1|root,COG0667@2|Bacteria,1TQYY@1239|Firmicutes,4HDCC@91061|Bacilli,26T55@186822|Paenibacillaceae	91061|Bacilli	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
DEZH2_k127_10114429_0	1195236.CTER_4718	1.648e-165	524.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,3WGNI@541000|Ruminococcaceae	186801|Clostridia	G	Fructose-1,6-bisphosphate aldolase, class II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
DEZH2_k127_10130018_2	509191.AEDB02000040_gene4583	4.506e-62	216.0	COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia,3WIWI@541000|Ruminococcaceae	186801|Clostridia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
DEZH2_k127_10130018_3	699246.HMPREF0868_1006	2.357e-56	199.0	COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,24H94@186801|Clostridia,26924@186813|unclassified Clostridiales	186801|Clostridia	J	Ribosomal protein S9/S16	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
DEZH2_k127_10130018_0	697281.Mahau_1412	2.115e-113	379.0	COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia,42EZJ@68295|Thermoanaerobacterales	186801|Clostridia	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
DEZH2_k127_10130018_5	1121428.DESHY_160205___1	1.647e-31	130.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,2621R@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised P-loop hydrolase UPF0079	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
DEZH2_k127_10130018_6	588581.Cpap_1323	1.679e-31	133.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,3WJ9X@541000|Ruminococcaceae	186801|Clostridia	O	Universal bacterial protein YeaZ	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
DEZH2_k127_10130018_4	1395587.P364_0124585	3.05e-38	149.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,4HIKU@91061|Bacilli,26RAQ@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
DEZH2_k127_10130018_7	1392491.JIAE01000001_gene579	1.457e-22	100.0	COG1925@1|root,COG1925@2|Bacteria,1TTT1@1239|Firmicutes,24PF9@186801|Clostridia,3WRW6@541000|Ruminococcaceae	186801|Clostridia	G	PTS HPr component phosphorylation site	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
DEZH2_k127_10130018_1	699246.HMPREF0868_1001	4.307e-100	334.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,267S1@186813|unclassified Clostridiales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
DEZH2_k127_10157779_1	1392491.JIAE01000001_gene1173	9.689e-24	103.0	COG0188@1|root,COG0188@2|Bacteria,1TPPU@1239|Firmicutes,24CU3@186801|Clostridia,3WG8X@541000|Ruminococcaceae	186801|Clostridia	L	PFAM DNA gyrase topoisomerase IV, subunit A	-	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
DEZH2_k127_10157779_0	1392491.JIAE01000001_gene1174	2.056e-109	376.0	COG0726@1|root,COG0726@2|Bacteria,1TWQ0@1239|Firmicutes,24BEF@186801|Clostridia,3WI2D@541000|Ruminococcaceae	186801|Clostridia	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
DEZH2_k127_10176134_1	325777.GW15_0222500	1.505e-29	121.0	2E8NX@1|root,33304@2|Bacteria,1NEFP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
DEZH2_k127_10176134_0	269482.Bcep1808_7631	3.322e-67	235.0	COG1192@1|root,COG1192@2|Bacteria,1RHQW@1224|Proteobacteria,2W4GY@28216|Betaproteobacteria,1KD4W@119060|Burkholderiaceae	28216|Betaproteobacteria	D	CobQ/CobB/MinD/ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
DEZH2_k127_10178587_1	1280664.AUIX01000036_gene1024	7.695e-26	109.0	COG1172@1|root,COG1172@2|Bacteria,1UYG4@1239|Firmicutes,24A8M@186801|Clostridia,4BYVP@830|Butyrivibrio	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_10178587_0	1449337.JQLL01000001_gene656	7.938e-317	984.0	COG1038@1|root,COG1038@2|Bacteria,1UHP9@1239|Firmicutes,4IS56@91061|Bacilli,27FPH@186828|Carnobacteriaceae	91061|Bacilli	C	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second	pyc	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
DEZH2_k127_1018392_2	1122927.KB895414_gene5445	2.564e-39	152.0	COG1082@1|root,COG1082@2|Bacteria,1UZ90@1239|Firmicutes,4HHIS@91061|Bacilli,26XYV@186822|Paenibacillaceae	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_1018392_1	1122927.KB895414_gene5445	1.355e-84	289.0	COG1082@1|root,COG1082@2|Bacteria,1UZ90@1239|Firmicutes,4HHIS@91061|Bacilli,26XYV@186822|Paenibacillaceae	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_1018392_0	1304880.JAGB01000002_gene2262	6.782e-102	338.0	COG0673@1|root,COG0673@2|Bacteria,1U4A4@1239|Firmicutes,249UF@186801|Clostridia	186801|Clostridia	E	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
DEZH2_k127_10191459_0	696369.KI912183_gene469	7.017e-258	817.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,2619M@186807|Peptococcaceae	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
DEZH2_k127_1025267_11	398512.JQKC01000018_gene2948	2.772e-36	139.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,3WGST@541000|Ruminococcaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
DEZH2_k127_1025267_4	1392491.JIAE01000001_gene1313	3.39e-100	346.0	COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,3WHRU@541000|Ruminococcaceae	186801|Clostridia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
DEZH2_k127_1025267_2	1195236.CTER_2209	5.059e-117	390.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,3WGRD@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
DEZH2_k127_1025267_8	1120973.AQXL01000133_gene1750	7.763e-54	205.0	COG1322@1|root,COG1322@2|Bacteria,1TPWI@1239|Firmicutes,4HE2N@91061|Bacilli	91061|Bacilli	S	RmuC domain protein	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
DEZH2_k127_1025267_3	1140.Synpcc7942_0777	1.09e-100	335.0	COG0190@1|root,COG0190@2|Bacteria,1G0FG@1117|Cyanobacteria,1GYIV@1129|Synechococcus	1117|Cyanobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
DEZH2_k127_1025267_0	398512.JQKC01000004_gene5144	2.782e-246	778.0	COG1032@1|root,COG1032@2|Bacteria,1TQ8X@1239|Firmicutes,248IW@186801|Clostridia,3WGM7@541000|Ruminococcaceae	186801|Clostridia	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
DEZH2_k127_1025267_1	699246.HMPREF0868_0628	1.157e-195	640.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia,267KR@186813|unclassified Clostridiales	186801|Clostridia	D	Ftsk_gamma	spoIIIE	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
DEZH2_k127_1025267_9	1410638.JHXJ01000023_gene835	1.769e-47	177.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,3WJNN@541000|Ruminococcaceae	186801|Clostridia	L	Psort location Cytoplasmic, score	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
DEZH2_k127_1025267_7	273068.TTE1362	1.028e-60	213.0	COG0328@1|root,COG0328@2|Bacteria,1V4A0@1239|Firmicutes,24FSS@186801|Clostridia,42G8B@68295|Thermoanaerobacterales	186801|Clostridia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
DEZH2_k127_1025267_6	1064535.MELS_2224	1.562e-64	230.0	COG0345@1|root,COG0345@2|Bacteria,1TP1E@1239|Firmicutes,4H489@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
DEZH2_k127_1025267_12	445972.ANACOL_01312	6.044e-32	130.0	COG4818@1|root,COG4818@2|Bacteria,1UQ1I@1239|Firmicutes,24SH6@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
DEZH2_k127_1025267_5	1449063.JMLS01000003_gene1894	1.276e-97	353.0	COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,4HANW@91061|Bacilli,26QRR@186822|Paenibacillaceae	91061|Bacilli	G	beta-galactosidase	ebgA	-	3.2.1.23	ko:K01190,ko:K12111	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
DEZH2_k127_1025267_10	1124982.MSI_15580	4.457e-40	155.0	COG0454@1|root,COG0456@2|Bacteria,2J8MB@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DEZH2_k127_10264401_2	1444310.JANV01000136_gene2606	0.0001261	55.0	COG0842@1|root,COG0842@2|Bacteria,1VBDS@1239|Firmicutes,4HMD1@91061|Bacilli,1ZFTX@1386|Bacillus	91061|Bacilli	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
DEZH2_k127_10264401_1	608534.GCWU000341_01206	6.846e-08	64.0	2EBY5@1|root,335XG@2|Bacteria,1UMAR@1239|Firmicutes,25GDW@186801|Clostridia,2PS88@265975|Oribacterium	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
DEZH2_k127_10264401_0	690850.Desaf_1256	9.325e-46	172.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2M8AB@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	pfam abc	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
DEZH2_k127_10269546_0	1121090.KB894685_gene3978	6.407e-63	239.0	COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,4HAY6@91061|Bacilli,1ZC70@1386|Bacillus	91061|Bacilli	L	ATP-dependent helicase deoxyribonuclease subunit B	rexB	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004527,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
DEZH2_k127_10269546_2	986075.CathTA2_2350	8.392e-31	127.0	COG0824@1|root,COG0824@2|Bacteria,1VAGM@1239|Firmicutes,4HIVC@91061|Bacilli	91061|Bacilli	L	thioesterase	yneP	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
DEZH2_k127_10269546_1	1410638.JHXJ01000042_gene2486	6.287e-58	210.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	-	-	2.3.1.51,6.2.1.3	ko:K00655,ko:K01897	ko00061,ko00071,ko00561,ko00564,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00561,map00564,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086,M00089	R01280,R02241,R09381	RC00004,RC00014,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,Acyltransferase
DEZH2_k127_10276416_2	1122921.KB898186_gene5026	2.679e-15	81.0	COG3271@1|root,COG3271@2|Bacteria,1VFV6@1239|Firmicutes,4I8YQ@91061|Bacilli,270QZ@186822|Paenibacillaceae	91061|Bacilli	S	Papain-like cysteine protease AvrRpt2	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C70
DEZH2_k127_10276416_0	203119.Cthe_1317	6.6e-84	287.0	COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,24824@186801|Clostridia,3WNGU@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF1732)	yicC	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
DEZH2_k127_10276416_1	888062.HMPREF9083_0033	6.381e-20	91.0	COG2052@1|root,COG2052@2|Bacteria,1VA40@1239|Firmicutes,4H545@909932|Negativicutes	909932|Negativicutes	S	Belongs to the UPF0296 family	-	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
DEZH2_k127_10315298_0	1009370.ALO_07583	1.215e-155	495.0	COG1897@1|root,COG1897@2|Bacteria,1TQVR@1239|Firmicutes,4H1XC@909932|Negativicutes	909932|Negativicutes	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metA	-	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	HTS
DEZH2_k127_10315298_3	394503.Ccel_2211	5.032e-35	138.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,36KFX@31979|Clostridiaceae	186801|Clostridia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
DEZH2_k127_10315298_1	404589.Anae109_2331	2.985e-90	318.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2YURF@29|Myxococcales	28221|Deltaproteobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
DEZH2_k127_10315298_2	509191.AEDB02000028_gene2878	1.656e-40	153.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,3WGQU@541000|Ruminococcaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
DEZH2_k127_10321351_5	537013.CLOSTMETH_01418	7.655e-26	110.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,3WH1I@541000|Ruminococcaceae	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
DEZH2_k127_10321351_4	1340434.AXVA01000019_gene935	6.264e-35	139.0	COG3797@1|root,COG3797@2|Bacteria,1V4KG@1239|Firmicutes,4HIGT@91061|Bacilli,1ZH6R@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
DEZH2_k127_10321351_3	351627.Csac_0232	1.06e-170	544.0	COG1509@1|root,COG1509@2|Bacteria,1TQQZ@1239|Firmicutes,249JV@186801|Clostridia,42FMB@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM lysine 2,3-aminomutase YodO family protein	-	-	5.4.3.9	ko:K19814	-	-	-	-	ko00000,ko01000	-	-	-	LAM_C,Radical_SAM
DEZH2_k127_10321351_0	545694.TREPR_2444	9.874e-318	985.0	COG3808@1|root,COG3808@2|Bacteria,2J6RD@203691|Spirochaetes	203691|Spirochaetes	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
DEZH2_k127_10321351_1	398512.JQKC01000004_gene5172	3.699e-229	717.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,3WH2N@541000|Ruminococcaceae	186801|Clostridia	C	Pyruvate carboxylase, C-terminal domain subunit K01960	pycB	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
DEZH2_k127_10321351_7	398512.JQKC01000004_gene5173	9.213e-06	52.0	2ES6N@1|root,33JRE@2|Bacteria,1VKZM@1239|Firmicutes,24URQ@186801|Clostridia	186801|Clostridia	S	Oxaloacetate decarboxylase, gamma chain	-	-	-	-	-	-	-	-	-	-	-	-	OAD_gamma
DEZH2_k127_10321351_6	509191.AEDB02000082_gene2531	9.775e-24	106.0	COG4770@1|root,COG4770@2|Bacteria,1VA1E@1239|Firmicutes,24MUJ@186801|Clostridia,3WK2X@541000|Ruminococcaceae	186801|Clostridia	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
DEZH2_k127_10321351_2	509191.AEDB02000082_gene2532	6.271e-178	562.0	COG1883@1|root,COG1883@2|Bacteria,1TPEP@1239|Firmicutes,248ET@186801|Clostridia,3WH3E@541000|Ruminococcaceae	186801|Clostridia	C	decarboxylase beta subunit	gcdB	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
DEZH2_k127_10329312_0	1195236.CTER_3623	4.622e-124	406.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,3WGP5@541000|Ruminococcaceae	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
DEZH2_k127_10329312_1	1392491.JIAE01000001_gene1411	2.521e-59	209.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,3WIZR@541000|Ruminococcaceae	186801|Clostridia	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
DEZH2_k127_10352477_0	720554.Clocl_2755	2.422e-288	893.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,3WG9W@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DEZH2_k127_10374755_1	1196322.A370_05338	7.644e-37	144.0	COG0657@1|root,COG0657@2|Bacteria,1V212@1239|Firmicutes,25B7P@186801|Clostridia,36WIX@31979|Clostridiaceae	186801|Clostridia	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
DEZH2_k127_10374755_0	469617.FUAG_01718	5.996e-124	402.0	COG1024@1|root,COG1024@2|Bacteria,3795J@32066|Fusobacteria	32066|Fusobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
DEZH2_k127_10374755_2	1216362.B437_04630	5.563e-33	131.0	COG1250@1|root,COG1250@2|Bacteria,378WJ@32066|Fusobacteria	32066|Fusobacteria	C	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	hbd	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
DEZH2_k127_10386847_0	1042156.CXIVA_15980	1.171e-65	231.0	COG1082@1|root,COG1082@2|Bacteria,1TPZ2@1239|Firmicutes,24AF7@186801|Clostridia,36GBX@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol)	iolE	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
DEZH2_k127_10386847_1	1298863.AUEP01000011_gene666	4.866e-13	80.0	COG1082@1|root,COG1082@2|Bacteria,2GJKJ@201174|Actinobacteria,4DPUG@85009|Propionibacteriales	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
DEZH2_k127_10416785_0	203119.Cthe_0156	2.136e-236	749.0	COG1032@1|root,COG1032@2|Bacteria,1TR2C@1239|Firmicutes,248HM@186801|Clostridia,3WHME@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DEZH2_k127_10416785_1	1410638.JHXJ01000003_gene1472	3.216e-205	648.0	COG0166@1|root,COG0166@2|Bacteria,1TP29@1239|Firmicutes,2487A@186801|Clostridia,3WHJX@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
DEZH2_k127_10416785_2	411902.CLOBOL_02728	7.643e-112	383.0	COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,21XZR@1506553|Lachnoclostridium	186801|Clostridia	C	Radical SAM domain protein	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,DUF4080,Radical_SAM
DEZH2_k127_10418560_2	699246.HMPREF0868_0347	1.223e-75	273.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,268NH@186813|unclassified Clostridiales	186801|Clostridia	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
DEZH2_k127_10418560_1	699246.HMPREF0868_0346	5.663e-98	325.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,26898@186813|unclassified Clostridiales	186801|Clostridia	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_10418560_3	720554.Clocl_2181	1.197e-64	227.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,3WJ07@541000|Ruminococcaceae	186801|Clostridia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
DEZH2_k127_10418560_0	1392491.JIAE01000001_gene942	2.097e-153	499.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,3WH3G@541000|Ruminococcaceae	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
DEZH2_k127_10418560_5	720554.Clocl_2189	3.698e-35	138.0	COG3856@1|root,COG3856@2|Bacteria,1VA6N@1239|Firmicutes,24N58@186801|Clostridia,3WP9X@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1290)	sbp	-	-	-	-	-	-	-	-	-	-	-	DUF1290
DEZH2_k127_10418560_4	699246.HMPREF0868_0343	3.57e-41	162.0	COG1589@1|root,COG1589@2|Bacteria	2|Bacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	-	6.3.2.4	ko:K01921,ko:K03589	ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	FtsQ,POTRA_1
DEZH2_k127_10418794_0	642492.Clole_2579	1.045e-216	681.0	COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,2484D@186801|Clostridia	186801|Clostridia	J	Asparaginyl-tRNA synthetase	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
DEZH2_k127_10418794_1	292459.STH370	4.83e-43	164.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia	186801|Clostridia	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
DEZH2_k127_10427294_0	1195236.CTER_3924	8.294e-101	333.0	COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,3WIDV@541000|Ruminococcaceae	186801|Clostridia	T	response regulator receiver	walR	-	-	ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_10427294_2	699246.HMPREF0868_1281	9.49e-77	274.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,26886@186813|unclassified Clostridiales	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	2.7.13.3	ko:K02484,ko:K07652	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
DEZH2_k127_10427294_1	1120746.CCNL01000011_gene1618	1.752e-79	271.0	COG0766@1|root,COG0766@2|Bacteria,2NNUV@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
DEZH2_k127_10429369_2	1121396.KB893053_gene2356	1.495e-91	314.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,42S6C@68525|delta/epsilon subdivisions,2WPAP@28221|Deltaproteobacteria,2MKIV@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.335	ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_10429369_4	1195236.CTER_3533	5.7e-67	237.0	COG0348@1|root,COG0348@2|Bacteria,1V66G@1239|Firmicutes	1239|Firmicutes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_9
DEZH2_k127_10429369_3	1220534.B655_1171	5.721e-77	271.0	COG0451@1|root,arCOG01369@2157|Archaea,2XUDM@28890|Euryarchaeota	28890|Euryarchaeota	M	NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
DEZH2_k127_10429369_5	720554.Clocl_3226	4.323e-61	215.0	COG0778@1|root,COG0778@2|Bacteria,1V3YJ@1239|Firmicutes,24BKH@186801|Clostridia,3WJMB@541000|Ruminococcaceae	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
DEZH2_k127_10429369_1	1145276.T479_23425	4.844e-127	414.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1TQ3E@1239|Firmicutes,4IV7U@91061|Bacilli	91061|Bacilli	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11,1.8.4.12	ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
DEZH2_k127_10429369_0	646529.Desaci_0322	1.175e-215	690.0	COG0651@1|root,COG0651@2|Bacteria,1TREH@1239|Firmicutes,248TK@186801|Clostridia,2609T@186807|Peptococcaceae	186801|Clostridia	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD	hyfB	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
DEZH2_k127_10468487_1	697282.Mettu_4161	6.609e-52	198.0	COG2204@1|root,COG4585@1|root,COG2204@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA,HisKA_3,PAS_3,PAS_4,PAS_9,PHY,Response_reg
DEZH2_k127_10468487_0	1485544.JQKP01000011_gene778	6.29e-55	197.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VQ9H@28216|Betaproteobacteria,44VRB@713636|Nitrosomonadales	28216|Betaproteobacteria	K	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DEZH2_k127_105248_0	203119.Cthe_2427	6.82e-88	302.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,25C8E@186801|Clostridia,3WHQ1@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	prmC	-	-	-	-	-	-	-	-	-	-	-	DUF1385,MTS
DEZH2_k127_105248_1	1125863.JAFN01000001_gene1724	1.072e-20	96.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WNH0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
DEZH2_k127_10541896_2	699246.HMPREF0868_0487	1.129e-58	211.0	COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,24HDH@186801|Clostridia,269H5@186813|unclassified Clostridiales	186801|Clostridia	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
DEZH2_k127_10541896_0	1121335.Clst_1372	9.715e-124	404.0	COG0463@1|root,COG0463@2|Bacteria,1TPR3@1239|Firmicutes,248Q5@186801|Clostridia,3WHGJ@541000|Ruminococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
DEZH2_k127_10541896_1	1195236.CTER_3161	2.652e-86	295.0	COG1297@1|root,COG1297@2|Bacteria,1TQJP@1239|Firmicutes,247JY@186801|Clostridia,3WHJB@541000|Ruminococcaceae	186801|Clostridia	S	oligopeptide transporter, OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
DEZH2_k127_10547242_2	1160721.RBI_I00386	2.321e-18	94.0	COG4758@1|root,COG4758@2|Bacteria,1V7WJ@1239|Firmicutes,24A1Z@186801|Clostridia,3WPNI@541000|Ruminococcaceae	186801|Clostridia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
DEZH2_k127_10547242_0	1120746.CCNL01000017_gene3097	3.137e-34	138.0	COG3279@1|root,COG3279@2|Bacteria,2NRMZ@2323|unclassified Bacteria	2|Bacteria	K	LytTr DNA-binding domain	XK27_02470	-	-	-	-	-	-	-	-	-	-	-	LytTR
DEZH2_k127_10547242_1	1451261.AS96_00190	8.044e-31	126.0	COG4420@1|root,COG4420@2|Bacteria,2IHZA@201174|Actinobacteria,4FT5C@85023|Microbacteriaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10557316_0	557598.LHK_02274	2.503e-89	304.0	COG3614@1|root,COG3829@1|root,COG4191@1|root,COG3614@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VKEQ@28216|Betaproteobacteria,2KPI9@206351|Neisseriales	206351|Neisseriales	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE,HATPase_c,HisKA,PAS_4
DEZH2_k127_10557316_1	667632.KB890184_gene402	2.915e-58	209.0	COG4566@1|root,COG4566@2|Bacteria,1R496@1224|Proteobacteria,2VKGB@28216|Betaproteobacteria,1K8JT@119060|Burkholderiaceae	28216|Betaproteobacteria	T	helix_turn_helix, Lux Regulon	fixJ2	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DEZH2_k127_10557316_2	349741.Amuc_0836	1.16e-34	134.0	COG0542@1|root,COG0542@2|Bacteria,46S4S@74201|Verrucomicrobia,2ITN7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
DEZH2_k127_10559397_1	203119.Cthe_1863	2.568e-66	231.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,3WGZJ@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DEZH2_k127_10559397_0	1195236.CTER_3374	1.676e-134	434.0	COG0548@1|root,COG0548@2|Bacteria,1TP0N@1239|Firmicutes,2486J@186801|Clostridia,3WGF0@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10565	AA_kinase
DEZH2_k127_10559397_2	1121335.Clst_2355	3.352e-25	106.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,3WGQA@541000|Ruminococcaceae	186801|Clostridia	E	acetylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DEZH2_k127_10579808_2	1410638.JHXJ01000011_gene700	1.509e-30	130.0	COG5427@1|root,COG5427@2|Bacteria,1UXXM@1239|Firmicutes,24EF9@186801|Clostridia,3WHFN@541000|Ruminococcaceae	186801|Clostridia	M	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10579808_1	203119.Cthe_3097	5.027e-101	338.0	COG1215@1|root,COG1215@2|Bacteria,1UI5W@1239|Firmicutes,25EJ5@186801|Clostridia,3WSJE@541000|Ruminococcaceae	186801|Clostridia	M	Family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
DEZH2_k127_10579808_0	1410638.JHXJ01000011_gene682	1.47e-305	950.0	COG0126@1|root,COG0149@1|root,COG0126@2|Bacteria,COG0149@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,3WGM9@541000|Ruminococcaceae	186801|Clostridia	G	Phosphoglycerate kinase	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
DEZH2_k127_10639254_4	1094980.Mpsy_0306	2.596e-28	123.0	arCOG14172@1|root,arCOG14172@2157|Archaea	1094980.Mpsy_0306|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10639254_3	351627.Csac_2476	1.143e-37	144.0	COG0347@1|root,COG0347@2|Bacteria,1V9Z5@1239|Firmicutes,24MNA@186801|Clostridia,42GTQ@68295|Thermoanaerobacterales	186801|Clostridia	K	PFAM Nitrogen regulatory protein P-II	glnB	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
DEZH2_k127_10639254_0	588581.Cpap_0800	1.142e-178	568.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,3WGAK@541000|Ruminococcaceae	186801|Clostridia	U	Ammonium Transporter Family	nrgA2	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
DEZH2_k127_10639254_1	545695.TREAZ_0056	1.858e-129	426.0	COG0246@1|root,COG0246@2|Bacteria,2J7H6@203691|Spirochaetes	203691|Spirochaetes	C	Mannitol dehydrogenase C-terminal domain	-	-	1.1.1.17	ko:K00009	ko00051,map00051	-	R02703	RC00085	ko00000,ko00001,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
DEZH2_k127_10639254_2	545695.TREAZ_0058	6.733e-128	417.0	COG0524@1|root,COG0524@2|Bacteria,2J7I0@203691|Spirochaetes	203691|Spirochaetes	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
DEZH2_k127_10648326_0	180332.JTGN01000005_gene2955	3.746e-42	164.0	COG1807@1|root,COG1807@2|Bacteria,1V1A0@1239|Firmicutes,24DT2@186801|Clostridia	186801|Clostridia	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1096126_3	445973.CLOBAR_00389	3.708e-39	155.0	COG0679@1|root,COG0679@2|Bacteria,1TR9W@1239|Firmicutes,24AQF@186801|Clostridia,25RD3@186804|Peptostreptococcaceae	186801|Clostridia	S	Transporter, auxin efflux carrier (AEC) family protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
DEZH2_k127_1096126_1	1469948.JPNB01000002_gene3362	3.552e-42	167.0	COG5018@1|root,COG5018@2|Bacteria,1TQJZ@1239|Firmicutes,24845@186801|Clostridia,36UN3@31979|Clostridiaceae	186801|Clostridia	L	Exonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
DEZH2_k127_1096126_0	537013.CLOSTMETH_01018	4.75e-100	336.0	COG0524@1|root,COG0524@2|Bacteria,1TPGM@1239|Firmicutes,247M1@186801|Clostridia,3WGC8@541000|Ruminococcaceae	186801|Clostridia	G	Psort location Cytoplasmic, score	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
DEZH2_k127_1096126_2	1392491.JIAE01000001_gene2043	2.71e-39	150.0	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia,3WGGT@541000|Ruminococcaceae	186801|Clostridia	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
DEZH2_k127_1127804_1	1469245.JFBG01000027_gene1472	7.3e-98	327.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,1SMBI@1236|Gammaproteobacteria,1X2WV@135613|Chromatiales	1236|Gammaproteobacteria	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	3.6.3.24	ko:K02031,ko:K15583,ko:K15587	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439,M00440	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
DEZH2_k127_1127804_0	1128421.JAGA01000002_gene834	1.384e-123	405.0	COG4608@1|root,COG4608@2|Bacteria,2NP9Y@2323|unclassified Bacteria	2|Bacteria	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
DEZH2_k127_1127804_2	1380387.JADM01000003_gene2659	7.783e-81	279.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1XIV4@135619|Oceanospirillales	135619|Oceanospirillales	P	(ABC) transporter, permease	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
DEZH2_k127_1133083_0	1392491.JIAE01000001_gene962	2.665e-128	419.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,3WH82@541000|Ruminococcaceae	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
DEZH2_k127_1133083_1	929506.CbC4_0478	1.601e-29	123.0	COG3402@1|root,COG3402@2|Bacteria,1VFTS@1239|Firmicutes,24KDK@186801|Clostridia,36JQ4@31979|Clostridiaceae	186801|Clostridia	S	Bacterial PH domain	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
DEZH2_k127_1133083_2	457396.CSBG_01666	1.772e-16	88.0	COG3428@1|root,COG3428@2|Bacteria,1TSRJ@1239|Firmicutes,24FG2@186801|Clostridia,36GWZ@31979|Clostridiaceae	186801|Clostridia	S	membrane	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
DEZH2_k127_1155492_0	1121472.AQWN01000006_gene1723	5.491e-119	386.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,260QM@186807|Peptococcaceae	186801|Clostridia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
DEZH2_k127_1155492_7	251221.35210983	1.494e-21	109.0	COG0515@1|root,COG0515@2|Bacteria,1G02X@1117|Cyanobacteria	1117|Cyanobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
DEZH2_k127_1155492_4	580327.Tthe_0281	3.53e-46	183.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,42FW4@68295|Thermoanaerobacterales	186801|Clostridia	U	PFAM Type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
DEZH2_k127_1155492_1	1392491.JIAE01000001_gene2343	9.577e-89	303.0	COG2207@1|root,COG2207@2|Bacteria,1TQ2W@1239|Firmicutes,24AFS@186801|Clostridia,3WIRY@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18,HTH_AraC
DEZH2_k127_1155492_3	340099.Teth39_0319	9.811e-85	287.0	COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,42EVI@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM GTP cyclohydrolase I Nitrile oxidoreductase	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
DEZH2_k127_1155492_2	203119.Cthe_2581	1.237e-86	295.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,3WHB5@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03115	Pterin_bind
DEZH2_k127_1155492_6	1273103.NM10_05366	8.345e-23	105.0	COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,4H54R@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
DEZH2_k127_1155492_5	420246.GTNG_0071	1.21e-39	152.0	COG0801@1|root,COG0801@2|Bacteria,1V6PR@1239|Firmicutes,4HIMG@91061|Bacilli,1WFJ4@129337|Geobacillus	91061|Bacilli	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
DEZH2_k127_1157028_1	658086.HMPREF0994_05357	1.658e-131	431.0	COG2936@1|root,COG2936@2|Bacteria,1TT0H@1239|Firmicutes,24BT1@186801|Clostridia,27KMS@186928|unclassified Lachnospiraceae	186801|Clostridia	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
DEZH2_k127_1157028_0	1235792.C808_03324	1.259e-191	608.0	COG3185@1|root,COG3185@2|Bacteria,1TQT2@1239|Firmicutes,249CY@186801|Clostridia,27ITV@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Pfam:DUF1446	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
DEZH2_k127_1157028_3	1235792.C808_03323	1.845e-43	160.0	2CIU6@1|root,32S8H@2|Bacteria,1VBBK@1239|Firmicutes,24PGQ@186801|Clostridia,27Q5A@186928|unclassified Lachnospiraceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1157028_5	1235792.C808_03325	3.657e-31	128.0	COG3829@1|root,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HTH_8,HisKA,PAS,PAS_3,PAS_4,PAS_9,Reg_prop,Response_reg,Y_Y_Y
DEZH2_k127_1157028_4	1195236.CTER_2595	5.491e-37	140.0	COG2768@1|root,COG2768@2|Bacteria,1UK08@1239|Firmicutes,25FG6@186801|Clostridia,3WK7Y@541000|Ruminococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
DEZH2_k127_1157028_2	646529.Desaci_1621	2.327e-104	346.0	COG1456@1|root,COG1456@2|Bacteria,1TPYJ@1239|Firmicutes,2588C@186801|Clostridia,2601E@186807|Peptococcaceae	186801|Clostridia	C	CO dehydrogenase acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
DEZH2_k127_1180729_0	44251.PDUR_21825	2.452e-47	183.0	COG0604@1|root,COG0604@2|Bacteria,1TT5J@1239|Firmicutes,4HCXG@91061|Bacilli,26X69@186822|Paenibacillaceae	91061|Bacilli	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1180729_2	1071073.KI530550_gene3620	2.587e-36	140.0	COG1695@1|root,COG1695@2|Bacteria,1V85H@1239|Firmicutes,4HJMF@91061|Bacilli,1ZH6V@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
DEZH2_k127_1180729_1	1121335.Clst_0953	3.691e-37	142.0	COG2233@1|root,COG2233@2|Bacteria,1TQKX@1239|Firmicutes,2485Z@186801|Clostridia,3WGSM@541000|Ruminococcaceae	186801|Clostridia	F	Psort location CytoplasmicMembrane, score 10.00	uraA	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
DEZH2_k127_1187063_2	33035.JPJF01000073_gene4411	2.704e-34	140.0	2EFH0@1|root,2ZA40@2|Bacteria,1V0W1@1239|Firmicutes,24BY4@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1187063_1	33035.JPJF01000073_gene4412	3.44e-111	373.0	COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia,3XZ6F@572511|Blautia	186801|Clostridia	S	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	AATase
DEZH2_k127_1187063_0	431943.CKL_3062	3.868e-239	747.0	COG1350@1|root,COG1350@2|Bacteria,1UI01@1239|Firmicutes,25E8Q@186801|Clostridia,36UNS@31979|Clostridiaceae	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DEZH2_k127_1200341_2	1321778.HMPREF1982_04502	3.565e-149	476.0	COG0031@1|root,COG0031@2|Bacteria,1TZEW@1239|Firmicutes,249RW@186801|Clostridia,267P0@186813|unclassified Clostridiales	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
DEZH2_k127_1200341_1	748727.CLJU_c23840	1.045e-194	613.0	COG0078@1|root,COG0078@2|Bacteria,1TNY4@1239|Firmicutes,249P4@186801|Clostridia,36F9U@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the ATCase OTCase family	ygeW	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
DEZH2_k127_1200341_5	1196322.A370_03992	1.117e-16	88.0	2FG4I@1|root,34811@2|Bacteria,1W01I@1239|Firmicutes,24NTK@186801|Clostridia,36SB8@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1200341_0	1262449.CP6013_0353	4.968e-199	631.0	COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,249W6@186801|Clostridia,36EQM@31979|Clostridiaceae	186801|Clostridia	F	PFAM amidohydrolase	hydA_1	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1,Urease_alpha
DEZH2_k127_1200341_4	309798.COPRO5265_1461	2.145e-31	126.0	COG3682@1|root,COG3682@2|Bacteria,1V7EY@1239|Firmicutes,24N11@186801|Clostridia,42H8J@68295|Thermoanaerobacterales	186801|Clostridia	K	penicillinase repressor	-	-	-	ko:K02171	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01504,ko03000	-	-	-	Penicillinase_R
DEZH2_k127_1200341_3	1259795.ARJK01000003_gene1244	5.704e-61	226.0	COG4219@1|root,COG4447@1|root,COG4219@2|Bacteria,COG4447@2|Bacteria,1TP3Z@1239|Firmicutes,24A30@186801|Clostridia,42JAQ@68295|Thermoanaerobacterales	186801|Clostridia	KT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
DEZH2_k127_1203436_3	445974.CLORAM_02830	8.35e-07	50.0	COG0346@1|root,COG0346@2|Bacteria,1UYR9@1239|Firmicutes,3VQFX@526524|Erysipelotrichia	1239|Firmicutes	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759,ko:K08234	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
DEZH2_k127_1203436_1	221288.JH992901_gene1848	2.205e-57	208.0	COG1028@1|root,COG1028@2|Bacteria,1G2PQ@1117|Cyanobacteria,1JIMZ@1189|Stigonemataceae	1117|Cyanobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
DEZH2_k127_1203436_2	1195236.CTER_1953	3.149e-36	145.0	COG1285@1|root,COG1285@2|Bacteria,1V409@1239|Firmicutes,249SQ@186801|Clostridia	186801|Clostridia	E	MgtC SapB transporter	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	ACT,MgtC
DEZH2_k127_1203436_0	1042156.CXIVA_21410	1.064e-86	296.0	COG0407@1|root,COG0407@2|Bacteria,1TPQ6@1239|Firmicutes,24A8C@186801|Clostridia,36EVJ@31979|Clostridiaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DEZH2_k127_1209702_1	696369.KI912183_gene2605	9.996e-30	121.0	COG0321@1|root,COG0321@2|Bacteria,1V44P@1239|Firmicutes,24GE9@186801|Clostridia	186801|Clostridia	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
DEZH2_k127_1209702_0	868595.Desca_0395	4.288e-117	383.0	COG0320@1|root,COG0320@2|Bacteria,1TQM4@1239|Firmicutes,2495Q@186801|Clostridia,2619Z@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
DEZH2_k127_1209702_2	1282360.ABAC460_01000	5.699e-13	74.0	COG1082@1|root,COG1082@2|Bacteria,1RA5P@1224|Proteobacteria,2U6VD@28211|Alphaproteobacteria,2KGWP@204458|Caulobacterales	204458|Caulobacterales	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_1214461_3	742735.HMPREF9467_00612	1.439e-42	162.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,21XFP@1506553|Lachnoclostridium	186801|Clostridia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
DEZH2_k127_1214461_0	386415.NT01CX_1071	5.982e-109	359.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,36EKX@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
DEZH2_k127_1214461_1	1487921.DP68_16800	1.649e-97	326.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,36E8S@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
DEZH2_k127_1214461_2	86416.Clopa_3980	5.4e-45	166.0	COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia,36K0M@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
DEZH2_k127_1246544_0	1392491.JIAE01000001_gene1555	1.51e-154	492.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,3WHFT@541000|Ruminococcaceae	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
DEZH2_k127_1246544_1	69042.WH5701_04060	4.608e-117	386.0	COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria,1GYG1@1129|Synechococcus	1117|Cyanobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
DEZH2_k127_1246544_4	1304875.JAFZ01000001_gene1113	1.322e-25	117.0	COG1284@1|root,COG1284@2|Bacteria,3T9XK@508458|Synergistetes	508458|Synergistetes	S	protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
DEZH2_k127_1246544_3	755731.Clo1100_2327	1.86e-57	205.0	COG1670@1|root,COG1670@2|Bacteria,1V9VH@1239|Firmicutes,25BC3@186801|Clostridia,36WCV@31979|Clostridiaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
DEZH2_k127_1246544_2	658655.HMPREF0988_02769	8.219e-117	384.0	COG3250@1|root,COG3250@2|Bacteria,1TPK7@1239|Firmicutes,247VE@186801|Clostridia,27J10@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Domain of unknown function (DUF4982)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
DEZH2_k127_1265593_1	411463.EUBVEN_01531	7.832e-72	250.0	COG1940@1|root,COG1940@2|Bacteria,1V1EQ@1239|Firmicutes,24FHR@186801|Clostridia	186801|Clostridia	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
DEZH2_k127_1265593_0	545695.TREAZ_0999	1.938e-246	766.0	COG1486@1|root,COG1486@2|Bacteria,2J6Z5@203691|Spirochaetes	203691|Spirochaetes	G	Family 4 glycosyl hydrolase	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
DEZH2_k127_1265593_2	1536773.R70331_11680	1e-28	122.0	COG0346@1|root,COG0346@2|Bacteria,1UYR9@1239|Firmicutes,4IG96@91061|Bacilli,2700C@186822|Paenibacillaceae	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
DEZH2_k127_1265593_3	1500306.JQLA01000003_gene4358	6.247e-07	53.0	COG0346@1|root,COG0346@2|Bacteria,1PJ3N@1224|Proteobacteria,2UF0Z@28211|Alphaproteobacteria,4BEYH@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
DEZH2_k127_1291851_5	203119.Cthe_2149	3.836e-25	108.0	COG1232@1|root,COG1232@2|Bacteria,1UQZD@1239|Firmicutes,24VCQ@186801|Clostridia,3WMB9@541000|Ruminococcaceae	186801|Clostridia	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
DEZH2_k127_1291851_1	1392491.JIAE01000001_gene627	5.311e-127	420.0	COG4198@1|root,COG4198@2|Bacteria,1TQ52@1239|Firmicutes,24985@186801|Clostridia,3WGM6@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
DEZH2_k127_1291851_4	886882.PPSC2_c2691	8.982e-30	130.0	COG0583@1|root,COG0583@2|Bacteria,1VH9J@1239|Firmicutes,4HQDD@91061|Bacilli,26TSV@186822|Paenibacillaceae	91061|Bacilli	K	Bacterial regulatory helix-turn-helix protein, lysR family	ywbI2	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
DEZH2_k127_1291851_2	931626.Awo_c12120	2.502e-105	347.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,24BBC@186801|Clostridia,25YSH@186806|Eubacteriaceae	186801|Clostridia	C	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
DEZH2_k127_1291851_3	309801.trd_A0012	3.45e-44	170.0	COG1028@1|root,COG1028@2|Bacteria,2G6SC@200795|Chloroflexi,27YY5@189775|Thermomicrobia	189775|Thermomicrobia	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
DEZH2_k127_1291851_0	699246.HMPREF0868_1344	3.783e-248	777.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,267ZC@186813|unclassified Clostridiales	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
DEZH2_k127_1292537_1	1123302.KB904155_gene1894	8.984e-08	57.0	COG0711@1|root,COG0711@2|Bacteria,1VB85@1239|Firmicutes,4HM64@91061|Bacilli	91061|Bacilli	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iYO844.BSU36850	ATP-synt_B
DEZH2_k127_1292537_0	1392491.JIAE01000001_gene1579	9.494e-217	690.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,3WGXD@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,OSCP
DEZH2_k127_1292537_2	1284708.HMPREF1634_05295	2.437e-07	56.0	COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia,3WCHP@538999|Clostridiales incertae sedis	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
DEZH2_k127_1307222_2	485918.Cpin_4916	1.329e-17	87.0	COG2911@1|root,COG3210@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,4NKIP@976|Bacteroidetes,1IW86@117747|Sphingobacteriia	976|Bacteroidetes	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4394,Gal_Lectin
DEZH2_k127_1307222_0	1304284.L21TH_1480	5.805e-140	453.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,36DZS@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
DEZH2_k127_1307222_1	469596.HMPREF9488_00176	1.167e-73	254.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,3VPCC@526524|Erysipelotrichia	526524|Erysipelotrichia	EP	Psort location CytoplasmicMembrane, score 10.00	oppC	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,OppC_N
DEZH2_k127_1314819_0	1345695.CLSA_c21450	6.411e-121	398.0	COG3275@1|root,COG3437@1|root,COG3275@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD_5,PAS,PAS_4
DEZH2_k127_1314819_2	1463887.KL590016_gene6323	1.453e-67	240.0	COG4932@1|root,COG4932@2|Bacteria,2GJ4T@201174|Actinobacteria	201174|Actinobacteria	M	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,DUF3494
DEZH2_k127_1314819_6	96561.Dole_2317	4.605e-14	73.0	2EFZF@1|root,339RM@2|Bacteria,1NH6S@1224|Proteobacteria,42WYZ@68525|delta/epsilon subdivisions,2WT48@28221|Deltaproteobacteria,2MPCB@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1314819_4	1410668.JNKC01000004_gene240	1.447e-24	107.0	COG0762@1|root,COG0762@2|Bacteria,1VN1M@1239|Firmicutes,24X1E@186801|Clostridia	186801|Clostridia	S	YGGT family	-	-	-	-	-	-	-	-	-	-	-	-	YGGT
DEZH2_k127_1314819_5	37659.JNLN01000001_gene1258	8.355e-24	102.0	COG2261@1|root,COG2261@2|Bacteria,1VEUE@1239|Firmicutes,24RAN@186801|Clostridia,36N4Z@31979|Clostridiaceae	186801|Clostridia	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
DEZH2_k127_1314819_1	1347369.CCAD010000080_gene3124	4.692e-90	306.0	COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,4HBGH@91061|Bacilli,1ZB4N@1386|Bacillus	91061|Bacilli	V	ABC transporter, ATP-binding protein	yhcH	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_1314819_3	1216932.CM240_3338	2.371e-35	154.0	COG1277@1|root,COG1277@2|Bacteria,1TT9E@1239|Firmicutes,25C7U@186801|Clostridia,36WR3@31979|Clostridiaceae	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
DEZH2_k127_1314819_8	888439.HMPREF9240_00390	3.422e-10	70.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4D3IX@85005|Actinomycetales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
DEZH2_k127_1315049_0	1121335.Clst_1023	1.361e-196	626.0	COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,3WI3M@541000|Ruminococcaceae	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
DEZH2_k127_1337160_2	1280689.AUJC01000001_gene2426	2.52e-09	61.0	COG0636@1|root,COG0636@2|Bacteria,1V8SD@1239|Firmicutes,24QMQ@186801|Clostridia,36MIS@31979|Clostridiaceae	186801|Clostridia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01165	ATP-synt_C
DEZH2_k127_1337160_1	1392491.JIAE01000001_gene1582	1.76e-67	238.0	COG0356@1|root,COG0356@2|Bacteria,1TQIT@1239|Firmicutes,24A6Q@186801|Clostridia,3WIAV@541000|Ruminococcaceae	186801|Clostridia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
DEZH2_k127_1337160_0	699246.HMPREF0868_0709	5.912e-109	354.0	COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,248FV@186801|Clostridia,2689H@186813|unclassified Clostridiales	186801|Clostridia	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
DEZH2_k127_1360760_0	457421.CBFG_01311	7.98e-153	491.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,26A52@186813|unclassified Clostridiales	186801|Clostridia	C	Acetokinase family	-	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
DEZH2_k127_1360760_1	1163671.JAGI01000002_gene2726	1.234e-79	272.0	COG2057@1|root,COG2057@2|Bacteria,1TNY5@1239|Firmicutes,247ZM@186801|Clostridia,36GAR@31979|Clostridiaceae	186801|Clostridia	I	3-oxoacid CoA-transferase, B subunit	ctfB1	-	2.8.3.5,2.8.3.8,2.8.3.9	ko:K01029,ko:K01035	ko00072,ko00280,ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00072,map00280,map00310,map00627,map00640,map00650,map01100,map01120,map02020	-	R00410,R01179,R01359,R01365,R07832	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
DEZH2_k127_1360760_2	1163671.JAGI01000002_gene2727	1.301e-63	222.0	COG1788@1|root,COG1788@2|Bacteria,1V21Q@1239|Firmicutes,25E61@186801|Clostridia,36UK0@31979|Clostridiaceae	186801|Clostridia	I	TIGRFAM 3-oxoacid CoA-transferase, A subunit	-	-	-	-	-	-	-	-	-	-	-	-	CoA_trans
DEZH2_k127_138023_0	56107.Cylst_1884	3.075e-107	351.0	COG1819@1|root,COG1819@2|Bacteria,1G036@1117|Cyanobacteria,1HMT6@1161|Nostocales	1117|Cyanobacteria	CG	Glycosyltransferase family 28 N-terminal domain	-	-	2.4.1.173	ko:K05841	-	-	-	-	ko00000,ko01000,ko01003	-	GT1	-	Glyco_transf_28,UDPGT
DEZH2_k127_138023_1	931277.C448_00722	1.772e-73	255.0	COG0702@1|root,arCOG03015@2157|Archaea,2Y1X3@28890|Euryarchaeota,23YEJ@183963|Halobacteria	183963|Halobacteria	M	NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
DEZH2_k127_1381494_1	1392491.JIAE01000001_gene2553	7.998e-16	85.0	28UUX@1|root,2ZGYY@2|Bacteria,1W4NC@1239|Firmicutes,257A0@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1381494_0	398512.JQKC01000001_gene2155	1.303e-44	170.0	COG1392@1|root,COG1392@2|Bacteria,1UYRI@1239|Firmicutes,24BCU@186801|Clostridia,3WKDM@541000|Ruminococcaceae	186801|Clostridia	P	phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
DEZH2_k127_1381494_2	1158608.I583_01456	3.427e-08	54.0	COG0306@1|root,COG0306@2|Bacteria,1TQ3D@1239|Firmicutes,4HAPD@91061|Bacilli,4B0CV@81852|Enterococcaceae	91061|Bacilli	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
DEZH2_k127_1387477_1	1410638.JHXJ01000010_gene146	1.113e-118	389.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,3WGVK@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the ribose-phosphate pyrophosphokinase family	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
DEZH2_k127_1387477_3	1392491.JIAE01000001_gene1367	1.735e-56	203.0	COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,3WH1B@541000|Ruminococcaceae	186801|Clostridia	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
DEZH2_k127_1387477_2	720554.Clocl_2538	8.53e-72	271.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,3WH2S@541000|Ruminococcaceae	186801|Clostridia	S	DNA internalization-related competence protein ComEC Rec2	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
DEZH2_k127_1387477_4	1392491.JIAE01000001_gene1371	5.663e-46	181.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,24ASN@186801|Clostridia,3WH6N@541000|Ruminococcaceae	186801|Clostridia	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
DEZH2_k127_1387477_0	1392491.JIAE01000001_gene1372	2.525e-207	649.0	COG0538@1|root,COG0538@2|Bacteria,1TSKB@1239|Firmicutes,247KX@186801|Clostridia,3WGXI@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the isocitrate and isopropylmalate dehydrogenases family	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DEZH2_k127_1387477_5	1128398.Curi_c13190	2.336e-43	163.0	COG3012@1|root,COG3012@2|Bacteria,1V1CC@1239|Firmicutes,24FYC@186801|Clostridia,2694V@186813|unclassified Clostridiales	186801|Clostridia	U	SEC-C motif	secA_2	-	-	-	-	-	-	-	-	-	-	-	SEC-C
DEZH2_k127_1399746_4	1230342.CTM_00665	1.038e-10	65.0	COG0642@1|root,COG2205@2|Bacteria,1TQHB@1239|Firmicutes,247S4@186801|Clostridia,36DXC@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
DEZH2_k127_1399746_1	1230342.CTM_00685	8.267e-26	111.0	COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia,36ERV@31979|Clostridiaceae	186801|Clostridia	P	domain protein	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
DEZH2_k127_1399746_3	658659.HMPREF0983_03180	4.771e-11	70.0	COG0569@1|root,COG0569@2|Bacteria,1V2ZF@1239|Firmicutes,3VRF7@526524|Erysipelotrichia	526524|Erysipelotrichia	P	Putative NAD(P)-binding	-	-	-	-	-	-	-	-	-	-	-	-	TrkA_N
DEZH2_k127_1399746_0	663278.Ethha_0174	6.656e-232	733.0	COG0531@1|root,COG0531@2|Bacteria,1TQE1@1239|Firmicutes,249N1@186801|Clostridia,3WG8M@541000|Ruminococcaceae	186801|Clostridia	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
DEZH2_k127_1399746_2	1042156.CXIVA_00960	1.334e-23	100.0	COG0407@1|root,COG0407@2|Bacteria,1TPQ6@1239|Firmicutes,24A8C@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DEZH2_k127_1404848_0	699246.HMPREF0868_0196	2.81e-312	962.0	COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,267JY@186813|unclassified Clostridiales	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
DEZH2_k127_1429978_1	997884.HMPREF1068_00803	5.184e-19	88.0	COG1649@1|root,COG4225@1|root,COG1649@2|Bacteria,COG4225@2|Bacteria,4NJ45@976|Bacteroidetes,2FMC1@200643|Bacteroidia,4AKDR@815|Bacteroidaceae	976|Bacteroidetes	G	COG NOG04984 non supervised orthologous group	-	-	3.1.1.53,3.2.1.172	ko:K05970,ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_88,SASA
DEZH2_k127_1429978_0	588581.Cpap_2802	4.005e-76	269.0	COG1940@1|root,COG1940@2|Bacteria,1TRT1@1239|Firmicutes,24A9E@186801|Clostridia,3WH5F@541000|Ruminococcaceae	186801|Clostridia	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
DEZH2_k127_1437805_0	1410638.JHXJ01000013_gene2280	1.885e-315	982.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,3WGW6@541000|Ruminococcaceae	186801|Clostridia	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
DEZH2_k127_1439090_1	1009370.ALO_01764	6.558e-60	209.0	COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,4H2UK@909932|Negativicutes	909932|Negativicutes	P	Metal cation transporter, ZIP family	gufA	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
DEZH2_k127_1439090_0	86416.Clopa_2120	1.906e-98	324.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia,36FVM@31979|Clostridiaceae	186801|Clostridia	S	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
DEZH2_k127_1439090_2	86416.Clopa_2120	1.73e-56	200.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia,36FVM@31979|Clostridiaceae	186801|Clostridia	S	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
DEZH2_k127_1439090_4	1158604.I591_00929	6.434e-06	55.0	2DFCB@1|root,2ZRAQ@2|Bacteria,1W1VF@1239|Firmicutes,4I1RY@91061|Bacilli,4B488@81852|Enterococcaceae	91061|Bacilli	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
DEZH2_k127_1439090_3	1123511.KB905839_gene581	5.178e-12	67.0	COG2199@1|root,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,4H568@909932|Negativicutes	909932|Negativicutes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9
DEZH2_k127_1468787_1	411474.COPEUT_01397	9.234e-44	163.0	COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,24JET@186801|Clostridia	186801|Clostridia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
DEZH2_k127_1468787_0	203119.Cthe_0566	5.543e-68	239.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,3WGTG@541000|Ruminococcaceae	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
DEZH2_k127_1471910_0	509191.AEDB02000064_gene554	5.381e-119	398.0	COG1022@1|root,COG1022@2|Bacteria,1TS22@1239|Firmicutes,24AZW@186801|Clostridia,3WHKE@541000|Ruminococcaceae	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
DEZH2_k127_1471910_4	1237149.C900_05730	2.297e-09	63.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
DEZH2_k127_1471910_2	592027.CLG_B2135	2.077e-37	145.0	COG1846@1|root,COG1846@2|Bacteria,1V6GY@1239|Firmicutes,24HTB@186801|Clostridia,36IZQ@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator, MarR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR,MarR_2
DEZH2_k127_1471910_1	203119.Cthe_2081	1.446e-114	386.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,3WH00@541000|Ruminococcaceae	186801|Clostridia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
DEZH2_k127_1471910_3	1195236.CTER_0503	1.882e-33	134.0	COG1180@1|root,COG1180@2|Bacteria,1V1GP@1239|Firmicutes,24G76@186801|Clostridia,3WIQV@541000|Ruminococcaceae	186801|Clostridia	O	TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
DEZH2_k127_1483457_1	903814.ELI_4480	1.757e-111	365.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,249CQ@186801|Clostridia,25YC1@186806|Eubacteriaceae	186801|Clostridia	P	E1-E2 ATPase	copB	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
DEZH2_k127_1483457_0	720554.Clocl_0475	1.964e-190	618.0	COG1609@1|root,COG1653@1|root,COG1609@2|Bacteria,COG1653@2|Bacteria,1V31R@1239|Firmicutes,249JU@186801|Clostridia,3WPJP@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_1,Peripla_BP_4,SBP_bac_8
DEZH2_k127_1508702_4	698758.AXY_22830	2.806e-40	153.0	COG3534@1|root,COG3534@2|Bacteria,1TPJ0@1239|Firmicutes,4HD18@91061|Bacilli	91061|Bacilli	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
DEZH2_k127_1508702_2	931276.Cspa_c29040	4.834e-85	294.0	COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1TS6T@1239|Firmicutes,247QK@186801|Clostridia,36DVX@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
DEZH2_k127_1508702_0	1227352.C173_11910	9.309e-172	552.0	COG3534@1|root,COG3534@2|Bacteria,1TPJ0@1239|Firmicutes,4HD18@91061|Bacilli,26TKE@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
DEZH2_k127_1508702_3	1499684.CCNP01000018_gene1308	8.277e-84	293.0	COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1TS6T@1239|Firmicutes,247QK@186801|Clostridia,36IQ0@31979|Clostridiaceae	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
DEZH2_k127_1508702_1	1536773.R70331_07055	4.566e-169	544.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli,26UYP@186822|Paenibacillaceae	91061|Bacilli	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
DEZH2_k127_1508702_5	1536774.H70357_08025	1.62e-15	82.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,26VZC@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_1525017_2	1206729.BAFZ01000034_gene4956	1.118e-15	76.0	COG2936@1|root,COG2936@2|Bacteria,2GKZH@201174|Actinobacteria,4G0KC@85025|Nocardiaceae	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
DEZH2_k127_1525017_1	536232.CLM_1855	3.069e-121	402.0	COG2223@1|root,COG2223@2|Bacteria,1TPR9@1239|Firmicutes,2483N@186801|Clostridia,36FJK@31979|Clostridiaceae	186801|Clostridia	P	Major Facilitator	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
DEZH2_k127_1525017_0	903818.KI912268_gene702	2.147e-271	855.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria	2|Bacteria	C	formate dehydrogenase (NAD+) activity	bzdV	-	1.97.1.9	ko:K12527	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_7,NADH-G_4Fe-4S_3,NADH_4Fe-4S,Pyr_redox_2
DEZH2_k127_1525017_3	1047013.AQSP01000091_gene642	5.669e-08	59.0	COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	sfrB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0055114,GO:0071944	1.12.1.3,1.17.1.10,1.6.5.3	ko:K00335,ko:K15022,ko:K18331	ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00134,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
DEZH2_k127_1569164_0	1120985.AUMI01000015_gene1650	7.255e-64	222.0	COG1897@1|root,COG1897@2|Bacteria,1TQVR@1239|Firmicutes,4H1XC@909932|Negativicutes	909932|Negativicutes	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metA	-	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	HTS
DEZH2_k127_1569164_1	1211844.CBLM010000096_gene763	1.06e-45	173.0	COG1272@1|root,COG1272@2|Bacteria,1TTA5@1239|Firmicutes,3VUPQ@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Haemolysin-III related	-	-	-	-	-	-	-	-	-	-	-	-	HlyIII
DEZH2_k127_1605546_0	1487923.DP73_03220	2.007e-309	972.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1TPR4@1239|Firmicutes,248TM@186801|Clostridia,266U2@186807|Peptococcaceae	186801|Clostridia	CE	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	1.97.1.9	ko:K12527	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
DEZH2_k127_1605546_2	1122947.FR7_3686	2.973e-181	576.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,4H362@909932|Negativicutes	909932|Negativicutes	F	selenium metabolism protein SsnA	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
DEZH2_k127_1605546_1	941824.TCEL_00051	1.02e-216	677.0	COG0624@1|root,COG0624@2|Bacteria,1TR99@1239|Firmicutes,248DC@186801|Clostridia,36G77@31979|Clostridiaceae	186801|Clostridia	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
DEZH2_k127_1611182_2	1235800.C819_01173	3.083e-28	118.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,27IGM@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Electron transfer flavoprotein FAD-binding domain	etfA	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha
DEZH2_k127_1611182_0	903814.ELI_0541	1.802e-126	410.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,25UTI@186806|Eubacteriaceae	186801|Clostridia	C	Psort location Cytoplasmic, score	etfB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363	1.3.1.108	ko:K03521,ko:K22431	-	-	-	-	ko00000,ko01000	-	-	-	ETF
DEZH2_k127_1611182_1	445971.ANASTE_01221	2.038e-98	323.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,25USM@186806|Eubacteriaceae	186801|Clostridia	C	Psort location Cytoplasmic, score	bcd	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DEZH2_k127_1616559_0	203119.Cthe_1312	1.004e-248	773.0	COG0423@1|root,COG0423@2|Bacteria,1TP94@1239|Firmicutes,248FB@186801|Clostridia,3WGTU@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
DEZH2_k127_1616559_1	699246.HMPREF0868_1481	4.194e-42	155.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,268N0@186813|unclassified Clostridiales	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DEZH2_k127_1656295_1	742733.HMPREF9469_02162	3.207e-55	196.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,21ZEC@1506553|Lachnoclostridium	186801|Clostridia	S	ABC transporter	yfmM	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
DEZH2_k127_1656295_0	1449050.JNLE01000003_gene1650	1.158e-75	261.0	COG1811@1|root,COG1811@2|Bacteria,1UH19@1239|Firmicutes,24AZ3@186801|Clostridia,36FKD@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF554)	-	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
DEZH2_k127_1656295_2	1121344.JHZO01000003_gene886	5.363e-05	51.0	COG3291@1|root,COG4733@1|root,COG5279@1|root,COG3291@2|Bacteria,COG4733@2|Bacteria,COG5279@2|Bacteria	2|Bacteria	D	protein involved in cytokinesis, contains TGc (transglutaminase protease-like) domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Flg_new,SLH,fn3
DEZH2_k127_1659858_1	394503.Ccel_2879	6.318e-125	405.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia,36DFR@31979|Clostridiaceae	186801|Clostridia	J	elongation factor G	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DEZH2_k127_1659858_3	1131462.DCF50_p968	7.458e-33	145.0	COG2197@1|root,COG2197@2|Bacteria,1U63E@1239|Firmicutes,24F84@186801|Clostridia,26450@186807|Peptococcaceae	186801|Clostridia	KT	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1659858_0	699246.HMPREF0868_0178	1.753e-141	462.0	COG1253@1|root,COG3064@1|root,COG1253@2|Bacteria,COG3064@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,267YU@186813|unclassified Clostridiales	186801|Clostridia	M	Psort location CytoplasmicMembrane, score	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
DEZH2_k127_1659858_2	1031288.AXAA01000010_gene432	9.059e-34	136.0	COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,24GK6@186801|Clostridia,36IAM@31979|Clostridiaceae	186801|Clostridia	F	IA, variant 1	ppaX	-	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
DEZH2_k127_1666187_3	1392491.JIAE01000001_gene1532	3.17e-56	205.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,3WGII@541000|Ruminococcaceae	186801|Clostridia	IJM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
DEZH2_k127_1666187_4	699246.HMPREF0868_1043	2.118e-40	158.0	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,25B02@186801|Clostridia	186801|Clostridia	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
DEZH2_k127_1666187_1	697281.Mahau_1600	6.797e-68	239.0	COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,24HEF@186801|Clostridia,42GBW@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
DEZH2_k127_1666187_0	509191.AEDB02000086_gene2751	7.892e-111	365.0	COG1737@1|root,COG1737@2|Bacteria,1TP7H@1239|Firmicutes,248ZD@186801|Clostridia,3WGRZ@541000|Ruminococcaceae	186801|Clostridia	K	transcriptional regulator RpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
DEZH2_k127_1666187_2	203119.Cthe_0701	2.368e-66	229.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,3WH2N@541000|Ruminococcaceae	186801|Clostridia	C	Pyruvate carboxylase, C-terminal domain subunit K01960	oadA	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
DEZH2_k127_1669504_0	935837.JAEK01000047_gene3152	7.173e-122	402.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,4HBUQ@91061|Bacilli,1ZEFX@1386|Bacillus	91061|Bacilli	E	Thermophilic metalloprotease (M29)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
DEZH2_k127_1669504_1	699246.HMPREF0868_1361	4.914e-32	143.0	COG1511@1|root,COG1511@2|Bacteria	2|Bacteria	Q	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
DEZH2_k127_1669504_2	1195236.CTER_4930	2.345e-30	120.0	COG3666@1|root,COG3666@2|Bacteria,1UZV8@1239|Firmicutes,24F4P@186801|Clostridia	186801|Clostridia	L	COG3666 Transposase and inactivated derivatives	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
DEZH2_k127_1669650_1	1195236.CTER_4930	2.345e-30	120.0	COG3666@1|root,COG3666@2|Bacteria,1UZV8@1239|Firmicutes,24F4P@186801|Clostridia	186801|Clostridia	L	COG3666 Transposase and inactivated derivatives	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
DEZH2_k127_1669650_0	56780.SYN_02383	2.536e-201	644.0	COG0574@1|root,COG0574@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2MR7X@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
DEZH2_k127_1685605_1	1280692.AUJL01000028_gene1923	2.586e-35	138.0	2CCSR@1|root,32RWC@2|Bacteria,1VHG8@1239|Firmicutes,24N36@186801|Clostridia,36K2K@31979|Clostridiaceae	186801|Clostridia	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
DEZH2_k127_1685605_0	1304866.K413DRAFT_2517	1.873e-39	163.0	COG1305@1|root,COG1305@2|Bacteria,1TP7G@1239|Firmicutes,24BSB@186801|Clostridia,36EZK@31979|Clostridiaceae	186801|Clostridia	E	Transglutaminase-like	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
DEZH2_k127_1685605_2	1297617.JPJD01000025_gene1186	1.867e-16	83.0	COG1459@1|root,COG1459@2|Bacteria,1TQRZ@1239|Firmicutes,249FV@186801|Clostridia,26919@186813|unclassified Clostridiales	186801|Clostridia	NU	Type II secretion system (T2SS), protein F	gspF	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
DEZH2_k127_1693888_0	443144.GM21_0189	2.191e-154	500.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,43U3R@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
DEZH2_k127_1726331_8	509191.AEDB02000035_gene2134	3.803e-36	139.0	COG4660@1|root,COG4660@2|Bacteria,1TSE7@1239|Firmicutes,24972@186801|Clostridia,3WHAI@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
DEZH2_k127_1726331_11	665956.HMPREF1032_01728	1.778e-22	104.0	COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,24JVM@186801|Clostridia,3WKJX@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfG	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
DEZH2_k127_1726331_4	537013.CLOSTMETH_01649	1.117e-87	298.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,3WGC0@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
DEZH2_k127_1726331_1	203119.Cthe_2430	1.078e-126	421.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,3WGZ1@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,MTHFR_C,RnfC_N,SLBB
DEZH2_k127_1726331_5	1105031.HMPREF1141_0162	9.562e-83	284.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,36E20@31979|Clostridiaceae	186801|Clostridia	C	Thioredoxin reductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
DEZH2_k127_1726331_0	1131462.DCF50_p1182	4.244e-219	691.0	COG0369@1|root,COG1151@2|Bacteria,1TP8X@1239|Firmicutes,247IN@186801|Clostridia,2601X@186807|Peptococcaceae	186801|Clostridia	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
DEZH2_k127_1726331_3	398512.JQKC01000012_gene258	2.636e-93	312.0	COG1149@1|root,COG1149@2|Bacteria,1VUEG@1239|Firmicutes,2503A@186801|Clostridia,3WSJM@541000|Ruminococcaceae	186801|Clostridia	C	PFAM 4Fe-4S	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_21,Fer4_6
DEZH2_k127_1726331_7	370438.PTH_0781	3.346e-65	230.0	COG0664@1|root,COG0664@2|Bacteria,1TSP9@1239|Firmicutes,24FRD@186801|Clostridia,261Q8@186807|Peptococcaceae	186801|Clostridia	K	Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
DEZH2_k127_1726331_6	1116232.AHBF01000026_gene6779	2.985e-65	243.0	COG2746@1|root,COG2746@2|Bacteria,2GNV9@201174|Actinobacteria	201174|Actinobacteria	V	aminoglycoside	yokD	-	2.3.1.81	ko:K00662	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Antibiotic_NAT
DEZH2_k127_1726331_10	665956.HMPREF1032_03554	5.881e-34	149.0	COG3393@1|root,COG3393@2|Bacteria,1UFJG@1239|Firmicutes,24M7G@186801|Clostridia	186801|Clostridia	S	PFAM GCN5-related N-acetyltransferase	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,GNAT_acetyltran
DEZH2_k127_1726331_2	1123405.AUMM01000019_gene2826	2.032e-117	390.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,4HBUQ@91061|Bacilli,26PD4@186821|Sporolactobacillaceae	91061|Bacilli	E	Thermophilic metalloprotease (M29)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
DEZH2_k127_1726331_9	1392493.JIAB01000001_gene2619	5.825e-34	147.0	COG4099@1|root,COG4099@2|Bacteria,1UPEI@1239|Firmicutes,249RF@186801|Clostridia,27KSZ@186928|unclassified Lachnospiraceae	186801|Clostridia	S	phospholipase Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1732306_3	1392491.JIAE01000001_gene2299	3.67e-32	127.0	COG4108@1|root,COG4108@2|Bacteria,1TPYT@1239|Firmicutes,247X3@186801|Clostridia,3WGUR@541000|Ruminococcaceae	186801|Clostridia	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
DEZH2_k127_1732306_2	1270193.JARP01000001_gene2250	1.407e-38	153.0	2C6BU@1|root,32S87@2|Bacteria,4NRX1@976|Bacteroidetes,1I6S7@117743|Flavobacteriia,2NYWP@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1732306_1	931626.Awo_c14140	1.92e-85	296.0	COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,248S5@186801|Clostridia,25WAN@186806|Eubacteriaceae	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
DEZH2_k127_1732306_0	1392491.JIAE01000001_gene2303	3.429e-209	662.0	COG0498@1|root,COG0498@2|Bacteria,1TPR0@1239|Firmicutes,248YY@186801|Clostridia,3WGWF@541000|Ruminococcaceae	186801|Clostridia	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS16355	PALP,Thr_synth_N
DEZH2_k127_1780350_0	394503.Ccel_2868	7.004e-136	446.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,36EBZ@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
DEZH2_k127_1780350_1	1408437.JNJN01000045_gene579	8.488e-12	76.0	COG4193@1|root,COG4942@1|root,COG4193@2|Bacteria,COG4942@2|Bacteria,1TYY9@1239|Firmicutes,248KE@186801|Clostridia,25Y9U@186806|Eubacteriaceae	186801|Clostridia	G	PFAM Phage late control gene D protein (GPD)	-	-	-	-	-	-	-	-	-	-	-	-	Glucosaminidase,NLPC_P60,Peptidase_M23
DEZH2_k127_1805742_1	1536772.R70723_32190	7.014e-07	52.0	COG0477@1|root,COG2814@2|Bacteria,1TRZB@1239|Firmicutes,4HBXV@91061|Bacilli,26SD3@186822|Paenibacillaceae	91061|Bacilli	EGP	Transporter	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1,MFS_3
DEZH2_k127_1805742_0	411473.RUMCAL_01693	9.448e-125	405.0	COG1373@1|root,COG1373@2|Bacteria,1TP7X@1239|Firmicutes,247ZX@186801|Clostridia,3WGAI@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
DEZH2_k127_18181_11	877421.AUJT01000036_gene1557	1.525e-05	53.0	COG2843@1|root,COG2843@2|Bacteria,1V20N@1239|Firmicutes,24AI2@186801|Clostridia,27M7I@186928|unclassified Lachnospiraceae	186801|Clostridia	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
DEZH2_k127_18181_1	1449126.JQKL01000022_gene141	1.298e-115	380.0	COG2070@1|root,COG2070@2|Bacteria,1TPX1@1239|Firmicutes,247YZ@186801|Clostridia,268W2@186813|unclassified Clostridiales	186801|Clostridia	S	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
DEZH2_k127_18181_4	1449337.JQLL01000001_gene1668	1.272e-68	245.0	COG2021@1|root,COG2021@2|Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	bioH	-	2.1.1.197,3.1.1.85,3.7.1.13,3.7.1.9,4.2.99.20	ko:K02169,ko:K02170,ko:K08680,ko:K10216,ko:K15756,ko:K16264	ko00130,ko00362,ko00621,ko00622,ko00643,ko00780,ko01100,ko01110,ko01120,ko01220,map00130,map00362,map00621,map00622,map00643,map00780,map01100,map01110,map01120,map01220	M00116,M00544,M00569,M00572	R02604,R05362,R05365,R05865,R08166,R09543,R09725	RC00003,RC00272,RC00460,RC00461,RC00753,RC00754,RC00755,RC00757,RC01337,RC01485,RC02148,RC02475	br01602,ko00000,ko00001,ko00002,ko01000,ko02000	2.A.4.1	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
DEZH2_k127_18181_0	315749.Bcer98_2013	1.587e-259	808.0	COG0488@1|root,COG0488@2|Bacteria,1TPW0@1239|Firmicutes,4HATH@91061|Bacilli,1ZBVV@1386|Bacillus	91061|Bacilli	S	COG0488 ATPase components of ABC transporters with duplicated ATPase domains	ykpA	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
DEZH2_k127_18181_9	994573.T472_0209535	1.559e-18	88.0	COG2732@1|root,COG2732@2|Bacteria,1VM0Z@1239|Firmicutes,24USA@186801|Clostridia,36VYH@31979|Clostridiaceae	186801|Clostridia	K	Barstar (barnase inhibitor)	-	-	-	ko:K03623	-	-	-	-	ko00000	-	-	-	Barstar
DEZH2_k127_18181_6	1121024.AUCD01000071_gene283	3.476e-44	166.0	COG4290@1|root,COG4290@2|Bacteria,1V7IV@1239|Firmicutes,4HMCP@91061|Bacilli,27HHA@186828|Carnobacteriaceae	91061|Bacilli	F	ribonuclease	-	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	Ribonuclease
DEZH2_k127_18181_8	646529.Desaci_4179	3.417e-24	112.0	COG5492@1|root,COG5492@2|Bacteria,1VX65@1239|Firmicutes,24K3U@186801|Clostridia	186801|Clostridia	N	domain, Protein	-	-	-	ko:K11059	-	-	-	-	ko00000,ko02042	-	-	-	-
DEZH2_k127_18181_5	645991.Sgly_1626	6.656e-56	201.0	COG0590@1|root,COG0590@2|Bacteria,1V7G0@1239|Firmicutes,24PS1@186801|Clostridia	186801|Clostridia	FJ	MafB19-like deaminase	-	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
DEZH2_k127_18181_10	537013.CLOSTMETH_01413	1.297e-16	81.0	COG5036@1|root,COG5036@2|Bacteria,1TYFN@1239|Firmicutes,24AGZ@186801|Clostridia,3WJCF@541000|Ruminococcaceae	186801|Clostridia	P	VTC domain	-	-	-	-	-	-	-	-	-	-	-	-	VTC
DEZH2_k127_18181_7	537013.CLOSTMETH_01413	7.447e-40	153.0	COG5036@1|root,COG5036@2|Bacteria,1TYFN@1239|Firmicutes,24AGZ@186801|Clostridia,3WJCF@541000|Ruminococcaceae	186801|Clostridia	P	VTC domain	-	-	-	-	-	-	-	-	-	-	-	-	VTC
DEZH2_k127_18181_3	767817.Desgi_0979	1.621e-82	282.0	COG1285@1|root,COG1285@2|Bacteria,1TRUW@1239|Firmicutes,248G4@186801|Clostridia,261Q6@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
DEZH2_k127_18181_2	394503.Ccel_0251	4.594e-83	286.0	COG5337@1|root,COG5337@2|Bacteria,1U0PJ@1239|Firmicutes,248HG@186801|Clostridia,36E1D@31979|Clostridiaceae	186801|Clostridia	M	CotH protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH
DEZH2_k127_1834955_1	871968.DESME_09425	9.693e-166	526.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,248FH@186801|Clostridia,264IZ@186807|Peptococcaceae	186801|Clostridia	L	Nucleotidyltransferase DNA polymerase involved in DNA repair	-	-	-	ko:K03502	-	-	-	-	ko00000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
DEZH2_k127_1834955_5	871968.DESME_09420	9.797e-26	110.0	2CD9B@1|root,32Y5H@2|Bacteria,1VEWC@1239|Firmicutes,24RYD@186801|Clostridia	186801|Clostridia	S	YolD-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YolD
DEZH2_k127_1834955_4	1313304.CALK_0146	3.212e-46	171.0	COG0245@1|root,COG0245@2|Bacteria	2|Bacteria	I	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity	ispF	GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0051483,GO:0071704,GO:1901576	2.1.1.228,2.7.7.60,4.6.1.12	ko:K00554,ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R00597,R05633,R05637	RC00002,RC00003,RC00334,RC01440	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	iNJ661.Rv3581c	IspD,YgbB
DEZH2_k127_1834955_0	1123008.KB905697_gene3183	1.387e-209	664.0	COG0365@1|root,COG0365@2|Bacteria,4NEAD@976|Bacteroidetes,2FNEM@200643|Bacteroidia,22VYT@171551|Porphyromonadaceae	976|Bacteroidetes	I	AMP-binding enzyme C-terminal domain	acsA	-	6.2.1.1,6.2.1.32	ko:K01895,ko:K08295	ko00010,ko00620,ko00627,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00627,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R00982,R01354	RC00004,RC00012,RC00043,RC00070,RC00174,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
DEZH2_k127_1834955_3	1235794.C811_00683	4.008e-60	213.0	COG1917@1|root,COG1917@2|Bacteria,2HUIY@201174|Actinobacteria,4CUVP@84998|Coriobacteriia	84998|Coriobacteriia	K	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_19,HTH_31
DEZH2_k127_1834955_7	1166018.FAES_2948	0.0004154	50.0	COG3118@1|root,COG3118@2|Bacteria,4NQ5B@976|Bacteroidetes,47QDT@768503|Cytophagia	976|Bacteroidetes	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
DEZH2_k127_1834955_2	398512.JQKC01000027_gene3905	3.834e-90	305.0	COG0489@1|root,COG0489@2|Bacteria,1TQ34@1239|Firmicutes,24817@186801|Clostridia,3WGBQ@541000|Ruminococcaceae	186801|Clostridia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co,ParA
DEZH2_k127_1834955_6	574376.BAMA_11550	2.909e-13	70.0	COG2813@1|root,COG2813@2|Bacteria,1V1BG@1239|Firmicutes,4HHCA@91061|Bacilli,1ZBPR@1386|Bacillus	91061|Bacilli	J	Methyltransferase	rsmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464	2.1.1.172	ko:K00564	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS
DEZH2_k127_183626_1	1519439.JPJG01000004_gene1062	2.037e-79	271.0	COG4277@1|root,COG4277@2|Bacteria,1TRT2@1239|Firmicutes,247UD@186801|Clostridia,2N6MX@216572|Oscillospiraceae	186801|Clostridia	S	Helix-hairpin-helix DNA-binding motif class 1	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Radical_SAM
DEZH2_k127_183626_4	1121335.Clst_2212	7.023e-30	130.0	COG1573@1|root,COG1573@2|Bacteria,1UY78@1239|Firmicutes,24FDP@186801|Clostridia,3WIWM@541000|Ruminococcaceae	186801|Clostridia	L	DNA metabolism protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4130
DEZH2_k127_183626_2	1392491.JIAE01000001_gene918	1.629e-40	154.0	COG0433@1|root,COG0433@2|Bacteria,1VF8X@1239|Firmicutes,24N9T@186801|Clostridia,3WJSW@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_183626_3	1195236.CTER_3599	3.172e-34	136.0	COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,24N1G@186801|Clostridia,3WJSY@541000|Ruminococcaceae	186801|Clostridia	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
DEZH2_k127_183626_0	699246.HMPREF0868_0247	5.59e-163	521.0	COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia,268A5@186813|unclassified Clostridiales	186801|Clostridia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
DEZH2_k127_183626_5	755731.Clo1100_1453	2.616e-24	105.0	COG2740@1|root,COG2740@2|Bacteria,1VEJS@1239|Firmicutes,24QSJ@186801|Clostridia,36KH1@31979|Clostridiaceae	186801|Clostridia	K	Nucleic-acid-binding protein implicated in transcription termination	ylxR	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
DEZH2_k127_183626_6	877420.ATVW01000001_gene2242	6.163e-12	71.0	COG1358@1|root,COG1358@2|Bacteria,1VEYG@1239|Firmicutes,24QP3@186801|Clostridia,27PF5@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_L7Ae
DEZH2_k127_1842552_2	1123075.AUDP01000004_gene875	6.537e-08	64.0	COG2508@1|root,COG2508@2|Bacteria,1TRRH@1239|Firmicutes	1239|Firmicutes	QT	COG2508 Regulator of polyketide synthase expression	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
DEZH2_k127_1842552_0	1232453.BAIF02000054_gene1157	2.209e-150	490.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia	186801|Clostridia	G	import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
DEZH2_k127_1842552_1	1469948.JPNB01000001_gene877	9.598e-25	109.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,36DTM@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440,ko:K17214	ko02010,map02010	M00212,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_185672_0	1120746.CCNL01000008_gene614	5.27e-317	979.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
DEZH2_k127_185672_1	871968.DESME_13310	2.558e-33	132.0	2DG6B@1|root,2ZUQ3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1869369_1	935837.JAEK01000016_gene1303	3.323e-14	85.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UCUQ@1239|Firmicutes,4I2MQ@91061|Bacilli,1ZMWY@1386|Bacillus	91061|Bacilli	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
DEZH2_k127_1869369_0	1449126.JQKL01000037_gene2047	1.018e-101	344.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,26ANK@186813|unclassified Clostridiales	186801|Clostridia	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
DEZH2_k127_1889114_0	720554.Clocl_1971	5.303e-170	544.0	COG1206@1|root,COG1206@2|Bacteria,1TP67@1239|Firmicutes,24971@186801|Clostridia,3WGA0@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
DEZH2_k127_1889114_3	1121335.Clst_1143	1.389e-50	191.0	COG5578@1|root,COG5578@2|Bacteria,1V87X@1239|Firmicutes,24J7V@186801|Clostridia,3WJA5@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function, DUF624	-	-	-	-	-	-	-	-	-	-	-	-	DUF624
DEZH2_k127_1889114_1	1280698.AUJS01000006_gene2845	7.143e-83	282.0	COG0289@1|root,COG0289@2|Bacteria,1TR9D@1239|Firmicutes,248FY@186801|Clostridia,27V9C@189330|Dorea	186801|Clostridia	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17035	DapB_C,DapB_N
DEZH2_k127_1889114_2	1121335.Clst_1145	2.451e-52	188.0	COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,247T5@186801|Clostridia,3WGWA@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS02100	DHDPS
DEZH2_k127_1929595_0	1195236.CTER_0502	0.0	1144.0	COG1328@1|root,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,3WGUQ@541000|Ruminococcaceae	186801|Clostridia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Glutaredoxin,NRDD
DEZH2_k127_1929595_2	1307761.L21SP2_2883	1.741e-24	105.0	arCOG15062@1|root,32Y8D@2|Bacteria,2J908@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PQ-loop
DEZH2_k127_1929595_1	411474.COPEUT_00107	5.31e-41	155.0	COG0461@1|root,COG0461@2|Bacteria,1V23H@1239|Firmicutes,24FTS@186801|Clostridia	186801|Clostridia	F	orotate phosphoribosyltransferase K00762	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	-
DEZH2_k127_192989_0	1382306.JNIM01000001_gene2353	2e-52	209.0	2DVYA@1|root,33XPC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1960564_3	1042156.CXIVA_00830	7.444e-48	175.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,36EGP@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the acetokinase family	buk	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
DEZH2_k127_1960564_5	1232436.CAPF01000063_gene1594	4.408e-18	87.0	COG0736@1|root,COG0736@2|Bacteria	2|Bacteria	I	holo-[acyl-carrier-protein] synthase activity	acpS	-	2.7.8.7,4.3.1.14	ko:K00997,ko:K18014	ko00310,ko00770,map00310,map00770	-	R01625,R03030	RC00002,RC00833	ko00000,ko00001,ko01000	-	-	-	ACPS
DEZH2_k127_1960564_4	1042156.CXIVA_00920	3.41e-18	88.0	COG3884@1|root,COG3884@2|Bacteria	2|Bacteria	I	thiolester hydrolase activity	-	-	3.1.2.21	ko:K01071	ko00061,ko01100,map00061,map01100	-	R04014,R08157,R08158	RC00014,RC00039	ko00000,ko00001,ko01000,ko01004	-	-	-	Acyl-ACP_TE
DEZH2_k127_1960564_1	5722.XP_001579287.1	7.247e-111	369.0	COG1621@1|root,KOG0228@2759|Eukaryota	2759|Eukaryota	G	beta-fructofuranosidase activity	-	-	3.2.1.26,3.2.1.65	ko:K01193,ko:K01212	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00802,R02410,R03635,R03921,R05624,R06088,R11311	RC00028,RC00077,RC03278	ko00000,ko00001,ko01000	-	GH32	-	Glyco_hydro_32C,Glyco_hydro_32N
DEZH2_k127_1960564_7	717772.THIAE_05875	3.824e-07	52.0	COG2865@1|root,COG2865@2|Bacteria	2|Bacteria	-	-	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_11,HTH_24,TrmB
DEZH2_k127_1960564_2	645991.Sgly_0732	1.251e-104	340.0	COG0317@1|root,COG0317@2|Bacteria,1TQW3@1239|Firmicutes,2483C@186801|Clostridia,26478@186807|Peptococcaceae	186801|Clostridia	KT	PFAM Region found in RelA SpoT proteins	-	-	-	-	-	-	-	-	-	-	-	-	RelA_SpoT
DEZH2_k127_1960564_6	509191.AEDB02000100_gene4086	4.144e-08	59.0	COG4980@1|root,COG4980@2|Bacteria,1VK4M@1239|Firmicutes,24VID@186801|Clostridia,3WPPA@541000|Ruminococcaceae	186801|Clostridia	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
DEZH2_k127_1960564_0	658655.HMPREF0988_00632	1.1e-120	392.0	COG0395@1|root,COG0395@2|Bacteria,1TP1G@1239|Firmicutes,247T2@186801|Clostridia,27JW4@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
DEZH2_k127_1963035_0	931626.Awo_c14850	3.841e-119	387.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia,25VEF@186806|Eubacteriaceae	186801|Clostridia	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
DEZH2_k127_1963035_1	871968.DESME_02690	1.624e-107	354.0	COG3384@1|root,COG3384@2|Bacteria,1TSRZ@1239|Firmicutes,24B3B@186801|Clostridia	186801|Clostridia	S	Extradiol ring-cleavage dioxygenase class III protein subunit B	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
DEZH2_k127_1963035_2	714943.Mucpa_5451	1.021e-14	76.0	COG1914@1|root,COG1914@2|Bacteria,4NDZ1@976|Bacteroidetes,1IQNY@117747|Sphingobacteriia	976|Bacteroidetes	P	COGs COG1914 Mn2 and Fe2 transporter of the NRAMP family	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
DEZH2_k127_198956_1	394503.Ccel_3251	6.771e-15	77.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
DEZH2_k127_198956_0	642492.Clole_0158	1.019e-231	721.0	COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,247XK@186801|Clostridia	186801|Clostridia	E	O-acetylhomoserine	mdeA1	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
DEZH2_k127_1997929_3	935837.JAEK01000013_gene4916	7.939e-35	137.0	COG0657@1|root,COG0657@2|Bacteria,1V212@1239|Firmicutes,4IQCI@91061|Bacilli,1ZRIR@1386|Bacillus	91061|Bacilli	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1997929_0	398512.JQKC01000013_gene1408	3.405e-216	695.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,3WNSP@541000|Ruminococcaceae	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
DEZH2_k127_1997929_1	509191.AEDB02000081_gene2467	3.663e-204	642.0	COG0019@1|root,COG0019@2|Bacteria,1TPQI@1239|Firmicutes,248NH@186801|Clostridia,3WGYP@541000|Ruminococcaceae	186801|Clostridia	E	carboxynorspermidine decarboxylase	nspC	-	4.1.1.96	ko:K13747	ko00330,ko01100,map00330,map01100	-	R09081,R09082	RC00299	ko00000,ko00001,ko01000	-	-	-	Orn_DAP_Arg_deC
DEZH2_k127_1997929_2	1487923.DP73_13350	1.465e-103	337.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,24AHW@186801|Clostridia,26029@186807|Peptococcaceae	186801|Clostridia	E	Saccharopine dehydrogenase	LYS1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
DEZH2_k127_200617_1	138119.DSY1690	4.129e-20	100.0	COG1196@1|root,COG1196@2|Bacteria,1UIE6@1239|Firmicutes,25EJB@186801|Clostridia,267AD@186807|Peptococcaceae	186801|Clostridia	D	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349,zf-HC2
DEZH2_k127_200617_0	1408422.JHYF01000013_gene623	2.855e-38	150.0	COG1695@1|root,COG1695@2|Bacteria,1V4KT@1239|Firmicutes,24954@186801|Clostridia,36W7U@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator, PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4180,PadR,Vir_act_alpha_C
DEZH2_k127_200617_2	1487923.DP73_03075	4.27e-14	74.0	COG1373@1|root,COG1373@2|Bacteria,1TP7X@1239|Firmicutes,247ZX@186801|Clostridia,2611C@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
DEZH2_k127_2017543_2	1460635.JCM19038_3956	3.053e-10	61.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,4HATE@91061|Bacilli	91061|Bacilli	V	ABC-type antimicrobial peptide transport system, permease component	yknZ	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DEZH2_k127_2017543_0	1151292.QEW_2084	9.157e-230	736.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
DEZH2_k127_2017543_1	1499683.CCFF01000016_gene785	8.753e-31	126.0	COG2182@1|root,COG2182@2|Bacteria,1VRPK@1239|Firmicutes,24Y63@186801|Clostridia,36W96@31979|Clostridiaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K15770	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	SBP_bac_8
DEZH2_k127_2056327_7	706587.Desti_5138	2.033e-09	66.0	COG1593@1|root,COG4665@1|root,COG1593@2|Bacteria,COG4665@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
DEZH2_k127_2056327_2	1461694.ATO9_16290	8.833e-65	238.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
DEZH2_k127_2056327_6	388399.SSE37_02735	1.746e-09	69.0	COG1638@1|root,COG1638@2|Bacteria,1RGMW@1224|Proteobacteria,2U7TF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
DEZH2_k127_2056327_5	903814.ELI_0552	2.911e-27	126.0	COG2207@1|root,COG2207@2|Bacteria,1V029@1239|Firmicutes,24GJ2@186801|Clostridia	186801|Clostridia	K	PFAM helix-turn-helix- domain containing protein, AraC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,dCache_1
DEZH2_k127_2056327_3	1256908.HMPREF0373_03454	1.628e-55	196.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	4.4.1.5,5.1.99.1	ko:K01759,ko:K05606,ko:K08234	ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02530,R02765,R09979	RC00004,RC00740,RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
DEZH2_k127_2056327_1	1256908.HMPREF0373_03457	4.091e-155	496.0	COG1063@1|root,COG1063@2|Bacteria,1VJ7E@1239|Firmicutes,25BYH@186801|Clostridia	186801|Clostridia	E	N-terminal domain of oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N
DEZH2_k127_2056327_4	696281.Desru_0068	2.008e-46	170.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,260GV@186807|Peptococcaceae	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
DEZH2_k127_2070602_2	1158338.JNLJ01000005_gene1475	4.654e-46	171.0	COG0698@1|root,COG0698@2|Bacteria,2G43P@200783|Aquificae	200783|Aquificae	G	ribose 5-phosphate isomerase B	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
DEZH2_k127_2070602_0	1121472.AQWN01000001_gene96	2.242e-170	544.0	COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,248NX@186801|Clostridia,260NX@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
DEZH2_k127_2070602_1	97138.C820_02415	1.36e-55	200.0	COG1208@1|root,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
DEZH2_k127_2080409_0	720554.Clocl_0016	0.0	1013.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,3WHE2@541000|Ruminococcaceae	186801|Clostridia	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
DEZH2_k127_2080409_1	370438.PTH_0734	2.712e-192	611.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,260N1@186807|Peptococcaceae	186801|Clostridia	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
DEZH2_k127_2086696_4	293227.XP_008717468.1	0.0003244	48.0	COG0553@1|root,KOG1001@2759|Eukaryota,38E02@33154|Opisthokonta,3NTZ9@4751|Fungi,3QPWB@4890|Ascomycota,20BPE@147545|Eurotiomycetes,3MRCP@451870|Chaetothyriomycetidae	4751|Fungi	A	HIRAN domain	-	-	2.3.2.27	ko:K15711	-	-	-	-	ko00000,ko01000,ko03400,ko04121	-	-	-	HIRAN,Helicase_C,SNF2_N,zf-C3HC4_2,zf-C3HC4_3,zf-PARP,zf-RING_2
DEZH2_k127_2086696_2	882378.RBRH_01597	8.506e-20	92.0	COG4627@1|root,COG4627@2|Bacteria,1N56P@1224|Proteobacteria,2VV7A@28216|Betaproteobacteria,1KHC7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
DEZH2_k127_2086696_1	868595.Desca_1814	2.437e-39	155.0	28JDD@1|root,2Z97S@2|Bacteria,1TRNJ@1239|Firmicutes,24HDV@186801|Clostridia,263EA@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2086696_0	1304880.JAGB01000003_gene1295	1.05e-133	432.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS11880	GDC-P
DEZH2_k127_2086696_3	1382306.JNIM01000001_gene77	1.711e-08	55.0	COG1003@1|root,COG1003@2|Bacteria,2G5MU@200795|Chloroflexi	200795|Chloroflexi	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
DEZH2_k127_2086921_3	768710.DesyoDRAFT_5205	3.697e-06	53.0	COG3793@1|root,COG3793@2|Bacteria,1UMIF@1239|Firmicutes,25GV0@186801|Clostridia	186801|Clostridia	P	PFAM Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2086921_1	1232447.BAHW02000022_gene1390	4.617e-90	305.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia	186801|Clostridia	C	glycyl-radical enzyme activating protein family	hpdA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
DEZH2_k127_2086921_2	536233.CLO_3132	5.646e-67	236.0	COG1349@1|root,COG1349@2|Bacteria,1TNYH@1239|Firmicutes,24BT5@186801|Clostridia,36GFV@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator, DeoR	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
DEZH2_k127_2086921_0	1262449.CP6013_0652	2.836e-121	399.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,36EFE@31979|Clostridiaceae	186801|Clostridia	C	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
DEZH2_k127_2090875_2	1415775.U729_948	1.175e-32	135.0	COG1807@1|root,COG1807@2|Bacteria,1V693@1239|Firmicutes,24M9H@186801|Clostridia	186801|Clostridia	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
DEZH2_k127_2090875_0	663278.Ethha_2084	3.295e-70	243.0	COG1776@1|root,COG1776@2|Bacteria,1UNKB@1239|Firmicutes,247MX@186801|Clostridia,3WJHJ@541000|Ruminococcaceae	186801|Clostridia	NT	Chemotaxis protein CheC, inhibitor of MCP methylation	cheC	-	-	ko:K03410	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheC
DEZH2_k127_2090875_1	663278.Ethha_2085	1.983e-42	159.0	COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,24HH7@186801|Clostridia,3WKBQ@541000|Ruminococcaceae	186801|Clostridia	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
DEZH2_k127_2095238_1	1117647.M5M_00060	5.27e-37	143.0	COG0226@1|root,COG0226@2|Bacteria,1N7RX@1224|Proteobacteria,1S97W@1236|Gammaproteobacteria,1J70Y@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0226 ABC-type phosphate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	PBP_like_2
DEZH2_k127_2095238_0	104623.Ser39006_00620	3.13e-94	316.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,1RNI1@1236|Gammaproteobacteria,4008P@613|Serratia	1236|Gammaproteobacteria	J	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0015976,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036307,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
DEZH2_k127_2095238_2	279714.FuraDRAFT_0622	2.074e-23	103.0	28JXP@1|root,2Z9N4@2|Bacteria,1MXG4@1224|Proteobacteria,2W49D@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
DEZH2_k127_2098111_4	1123405.AUMM01000034_gene1685	0.0007795	51.0	COG3595@1|root,COG3595@2|Bacteria,1VATC@1239|Firmicutes,4HKW2@91061|Bacilli,26PWN@186821|Sporolactobacillaceae	91061|Bacilli	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
DEZH2_k127_2098111_1	592010.GCWU000182_001346	1.178e-30	128.0	COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,4HKJ1@91061|Bacilli,27E41@186827|Aerococcaceae	91061|Bacilli	L	SLBB domain	comEA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
DEZH2_k127_2098111_2	699246.HMPREF0868_0800	2.076e-30	126.0	COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,24MVA@186801|Clostridia	186801|Clostridia	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
DEZH2_k127_2098111_0	1392491.JIAE01000001_gene1091	1.959e-65	239.0	COG1057@1|root,COG1713@1|root,COG1057@2|Bacteria,COG1713@2|Bacteria,1V6Y1@1239|Firmicutes,24HN2@186801|Clostridia,3WJZX@541000|Ruminococcaceae	186801|Clostridia	H	HD superfamily hydrolase involved in NAD metabolism	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,HD
DEZH2_k127_2098111_3	635013.TherJR_0831	6.014e-12	66.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,2609N@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
DEZH2_k127_2101936_2	665950.HMPREF1025_00919	6.983e-110	370.0	COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,27IK5@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Uncharacterized protein family UPF0004	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
DEZH2_k127_2101936_3	1121335.Clst_2057	8.322e-23	99.0	COG1925@1|root,COG1925@2|Bacteria,1VAQP@1239|Firmicutes,24N19@186801|Clostridia,3WKEN@541000|Ruminococcaceae	186801|Clostridia	G	PTS HPr component phosphorylation site	-	-	-	-	-	-	-	-	-	-	-	-	PTS-HPr
DEZH2_k127_2101936_1	429009.Adeg_0210	1.692e-138	461.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,42FKG@68295|Thermoanaerobacterales	186801|Clostridia	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
DEZH2_k127_2101936_4	699246.HMPREF0868_0051	7.915e-18	85.0	COG1314@1|root,COG1314@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
DEZH2_k127_2101936_0	1209989.TepiRe1_1537	1.428e-227	725.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
DEZH2_k127_2104812_0	1121335.Clst_2244	4.499e-92	319.0	COG1524@1|root,COG1524@2|Bacteria,1UZDM@1239|Firmicutes,24DP2@186801|Clostridia	186801|Clostridia	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
DEZH2_k127_2104812_1	1105031.HMPREF1141_1035	1.047e-71	254.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,36F7S@31979|Clostridiaceae	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
DEZH2_k127_2104812_2	1123511.KB905877_gene2401	6.25e-35	140.0	COG1268@1|root,COG1268@2|Bacteria,1VAY6@1239|Firmicutes,4H4H5@909932|Negativicutes	909932|Negativicutes	S	PFAM BioY protein	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
DEZH2_k127_2110883_1	97139.C824_03949	1.504e-81	276.0	COG0280@1|root,COG0280@2|Bacteria,1TS7B@1239|Firmicutes,2496E@186801|Clostridia	186801|Clostridia	C	Phosphate acetyl/butaryl transferase	-	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
DEZH2_k127_2110883_0	397288.C806_04064	5.4e-259	805.0	COG1053@1|root,COG1053@2|Bacteria,1TT1Q@1239|Firmicutes,249N4@186801|Clostridia,27JNF@186928|unclassified Lachnospiraceae	186801|Clostridia	C	FAD dependent oxidoreductase	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Fer4,NADH_4Fe-4S
DEZH2_k127_2116881_2	663278.Ethha_0043	1.182e-33	140.0	COG2199@1|root,COG5002@1|root,COG2199@2|Bacteria,COG5002@2|Bacteria,1UQA9@1239|Firmicutes,24G0P@186801|Clostridia,3WSRV@541000|Ruminococcaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,PAS_9
DEZH2_k127_2116881_1	1131462.DCF50_p699	1.52e-94	329.0	COG2199@1|root,COG5002@1|root,COG2199@2|Bacteria,COG5002@2|Bacteria,1TS5J@1239|Firmicutes,25E4Y@186801|Clostridia,267DZ@186807|Peptococcaceae	186801|Clostridia	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,GGDEF,PAS_3,PAS_9
DEZH2_k127_2116881_0	1226325.HMPREF1548_06302	1.225e-221	693.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,36F3K@31979|Clostridiaceae	186801|Clostridia	G	Carbohydrate kinase, FGGY	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
DEZH2_k127_2125017_1	720554.Clocl_0114	4.722e-32	138.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,3WHFQ@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the V-ATPase 116 kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
DEZH2_k127_2125017_0	1410638.JHXJ01000033_gene31	3.421e-85	290.0	COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,3WGEY@541000|Ruminococcaceae	186801|Clostridia	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain	pgcA	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
DEZH2_k127_2135268_11	509191.AEDB02000028_gene2901	3.182e-09	58.0	2EFGV@1|root,3399G@2|Bacteria,1U5Y2@1239|Firmicutes,24WP5@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2135268_15	398512.JQKC01000019_gene3454	0.0007318	42.0	2BBRW@1|root,325A1@2|Bacteria,1URDA@1239|Firmicutes,24WPQ@186801|Clostridia,3WR30@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2135268_14	1499680.CCFE01000025_gene3185	0.0001254	46.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2135268_9	509191.AEDB02000023_gene3585	2.703e-30	132.0	2EAFW@1|root,334J8@2|Bacteria,1VH80@1239|Firmicutes,24TFF@186801|Clostridia,3WM0I@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2135268_13	398512.JQKC01000019_gene3454	9.87e-06	48.0	2BBRW@1|root,325A1@2|Bacteria,1URDA@1239|Firmicutes,24WPQ@186801|Clostridia,3WR30@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2135268_1	699246.HMPREF0868_1264	8.738e-143	458.0	COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,24999@186801|Clostridia,26815@186813|unclassified Clostridiales	186801|Clostridia	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
DEZH2_k127_2135268_10	1122947.FR7_3941	1.369e-11	66.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,4H20N@909932|Negativicutes	909932|Negativicutes	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
DEZH2_k127_2135268_6	720554.Clocl_1133	1.029e-66	235.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,3WGX6@541000|Ruminococcaceae	186801|Clostridia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
DEZH2_k127_2135268_3	699246.HMPREF0868_1262	3.124e-97	326.0	COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia,268CJ@186813|unclassified Clostridiales	186801|Clostridia	S	Displays ATPase and GTPase activities	yvcJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
DEZH2_k127_2135268_2	1304880.JAGB01000001_gene357	1.418e-102	344.0	COG0391@1|root,COG0391@2|Bacteria,1TPNV@1239|Firmicutes,248G0@186801|Clostridia	186801|Clostridia	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
DEZH2_k127_2135268_8	699246.HMPREF0868_1261	2.297e-51	194.0	COG1481@1|root,COG1481@2|Bacteria,1TP2X@1239|Firmicutes,2484M@186801|Clostridia,268FN@186813|unclassified Clostridiales	186801|Clostridia	K	May be required for sporulation	whiA	-	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
DEZH2_k127_2135268_7	1408437.JNJN01000001_gene1721	3.955e-59	209.0	COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,24HVV@186801|Clostridia,25W60@186806|Eubacteriaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
DEZH2_k127_2135268_4	1469948.JPNB01000001_gene903	2.224e-91	312.0	COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,36EEA@31979|Clostridiaceae	186801|Clostridia	E	Cleaves the N-terminal amino acid of tripeptides	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
DEZH2_k127_2135268_0	1410638.JHXJ01000004_gene2075	2.161e-151	499.0	COG1520@1|root,COG1520@2|Bacteria,1TQ7F@1239|Firmicutes,249BV@186801|Clostridia,3WHZZ@541000|Ruminococcaceae	186801|Clostridia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2
DEZH2_k127_2135268_5	226185.EF_2442	2.001e-89	302.0	COG0306@1|root,COG0306@2|Bacteria,1TQ3D@1239|Firmicutes,4HAPD@91061|Bacilli,4B0CV@81852|Enterococcaceae	91061|Bacilli	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
DEZH2_k127_2146149_2	1454004.AW11_01169	2.154e-60	215.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,2VUA6@28216|Betaproteobacteria	28216|Betaproteobacteria	L	nuclease	-	-	-	-	-	-	-	-	-	-	-	-	SNase
DEZH2_k127_2146149_0	375286.mma_3159	4.58e-175	556.0	COG3392@1|root,COG3392@2|Bacteria,1PRRN@1224|Proteobacteria,2W5K4@28216|Betaproteobacteria	28216|Betaproteobacteria	H	D12 class N6 adenine-specific DNA methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	MethyltransfD12
DEZH2_k127_2146149_1	375286.mma_3160	1.223e-123	407.0	2DNFJ@1|root,32X9K@2|Bacteria,1N1YY@1224|Proteobacteria,2W653@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2150012_2	1226325.HMPREF1548_03071	1.278e-47	173.0	COG2843@1|root,COG2843@2|Bacteria,1V20N@1239|Firmicutes,24AI2@186801|Clostridia	186801|Clostridia	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
DEZH2_k127_2150012_3	1499684.CCNP01000021_gene2937	2.485e-13	77.0	2DA7D@1|root,32TUU@2|Bacteria,1VAVQ@1239|Firmicutes,24UAT@186801|Clostridia,36Q98@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2150012_1	1226325.HMPREF1548_00823	1.981e-66	229.0	COG1803@1|root,COG1803@2|Bacteria,1V3KQ@1239|Firmicutes,24FUQ@186801|Clostridia,36IPD@31979|Clostridiaceae	186801|Clostridia	G	methylglyoxal synthase	mgsA	-	2.7.1.24,4.2.3.3	ko:K00859,ko:K01734	ko00640,ko00770,ko01100,ko01120,map00640,map00770,map01100,map01120	M00120	R00130,R01016	RC00002,RC00078,RC00424	ko00000,ko00001,ko00002,ko01000	-	-	-	MGS
DEZH2_k127_2150012_0	522772.Dacet_0227	2.202e-106	351.0	COG1145@1|root,COG1145@2|Bacteria,2GF4R@200930|Deferribacteres	200930|Deferribacteres	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
DEZH2_k127_215847_2	1230460.C495_16870	8.123e-05	52.0	arCOG02499@1|root,arCOG02521@1|root,arCOG04500@1|root,arCOG07560@1|root,arCOG02499@2157|Archaea,arCOG02521@2157|Archaea,arCOG04500@2157|Archaea,arCOG07560@2157|Archaea	2157|Archaea	Q	Archaeal Type IV pilin, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,Glyco_hydro_28,NosD,PKD,Pectate_lyase_3
DEZH2_k127_215847_1	553973.CLOHYLEM_06434	2.092e-15	88.0	COG1879@1|root,COG1879@2|Bacteria,1V0EN@1239|Firmicutes,24IY5@186801|Clostridia	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
DEZH2_k127_215847_0	1469948.JPNB01000001_gene877	2.78e-64	228.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,36DTM@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440,ko:K17214	ko02010,map02010	M00212,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_2203278_3	1088721.NSU_1592	3.021e-06	54.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,2K1BU@204457|Sphingomonadales	204457|Sphingomonadales	S	PFAM amidohydrolase 2	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
DEZH2_k127_2203278_0	1301100.HG529390_gene5070	5.189e-111	362.0	COG0247@1|root,COG0247@2|Bacteria,1TPAM@1239|Firmicutes,24I1E@186801|Clostridia,36WH8@31979|Clostridiaceae	186801|Clostridia	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CCG
DEZH2_k127_2203278_1	33035.JPJF01000028_gene2768	3.307e-57	201.0	COG0346@1|root,COG0346@2|Bacteria,1V6K3@1239|Firmicutes,24J94@186801|Clostridia,3Y06G@572511|Blautia	186801|Clostridia	E	Psort location Cytoplasmic, score 8.87	gloA	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
DEZH2_k127_2203318_0	1321784.HMPREF1987_00764	6.707e-102	341.0	COG2211@1|root,COG2211@2|Bacteria,1TRP7@1239|Firmicutes,24B5F@186801|Clostridia	186801|Clostridia	G	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_2,PUCC
DEZH2_k127_2203318_1	1209989.TepiRe1_1756	5.819e-43	165.0	COG2059@1|root,COG2059@2|Bacteria,1V43H@1239|Firmicutes,24JTX@186801|Clostridia,42GI8@68295|Thermoanaerobacterales	186801|Clostridia	P	chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
DEZH2_k127_2203318_2	994573.T472_0215605	2.994e-09	59.0	COG2059@1|root,COG2059@2|Bacteria,1V42U@1239|Firmicutes,24HA0@186801|Clostridia,36ICK@31979|Clostridiaceae	186801|Clostridia	P	Chromate	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
DEZH2_k127_2224393_0	1209989.TepiRe1_1944	6.771e-192	605.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,42F5T@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM malic	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
DEZH2_k127_2224393_1	398512.JQKC01000030_gene4408	2.861e-57	203.0	COG1522@1|root,COG1522@2|Bacteria,1V3PB@1239|Firmicutes,24I3N@186801|Clostridia,3WIWV@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulator, AsnC family	Lrp	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
DEZH2_k127_2224393_2	1121333.JMLH01000002_gene205	8.282e-09	57.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,3VPD3@526524|Erysipelotrichia	526524|Erysipelotrichia	E	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
DEZH2_k127_2246201_1	1356854.N007_13570	0.0008302	46.0	COG1277@1|root,COG1277@2|Bacteria,1TT9E@1239|Firmicutes,4HJPV@91061|Bacilli	91061|Bacilli	S	ABC-type transport system involved in multi-copper enzyme maturation, permease component	bcrB3	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
DEZH2_k127_2246201_0	428125.CLOLEP_00228	9.986e-96	320.0	COG0119@1|root,COG0119@2|Bacteria,1TRIK@1239|Firmicutes,249Q4@186801|Clostridia,3WI0A@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
DEZH2_k127_2258247_3	1131462.DCF50_p699	4.596e-72	252.0	COG2199@1|root,COG5002@1|root,COG2199@2|Bacteria,COG5002@2|Bacteria,1TS5J@1239|Firmicutes,25E4Y@186801|Clostridia,267DZ@186807|Peptococcaceae	186801|Clostridia	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,GGDEF,PAS_3,PAS_9
DEZH2_k127_2258247_0	756499.Desde_1533	2.962e-132	431.0	COG0310@1|root,COG0310@2|Bacteria,1TPEN@1239|Firmicutes,248S9@186801|Clostridia,260YP@186807|Peptococcaceae	186801|Clostridia	P	PFAM Cobalt uptake substrate-specific transmembrane region	cbiM2	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
DEZH2_k127_2258247_2	634956.Geoth_2320	9.382e-76	261.0	COG0619@1|root,COG0619@2|Bacteria,1U6XW@1239|Firmicutes,4IFQU@91061|Bacilli,1WHFY@129337|Geobacillus	91061|Bacilli	P	Cobalt transport protein	-	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
DEZH2_k127_2258247_1	645991.Sgly_3326	4.041e-83	283.0	COG1122@1|root,COG1122@2|Bacteria,1TSSM@1239|Firmicutes,249KS@186801|Clostridia,2602Q@186807|Peptococcaceae	186801|Clostridia	P	ABC-type cobalt transport system ATPase component	cbiO	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
DEZH2_k127_2261706_0	1121334.KB911072_gene2553	5.684e-227	710.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,3WGXK@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
DEZH2_k127_2261706_1	1410632.JHWW01000001_gene989	2.718e-202	638.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,27I7J@186928|unclassified Lachnospiraceae	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
DEZH2_k127_2294648_2	1280680.AUJU01000008_gene157	5.825e-06	50.0	COG0395@1|root,COG0395@2|Bacteria,1TP1G@1239|Firmicutes,24BAS@186801|Clostridia,4C1Y6@830|Butyrivibrio	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
DEZH2_k127_2294648_0	658655.HMPREF0988_00633	1.562e-147	472.0	COG4209@1|root,COG4209@2|Bacteria,1TQFY@1239|Firmicutes,24923@186801|Clostridia,27INJ@186928|unclassified Lachnospiraceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
DEZH2_k127_2294648_1	658655.HMPREF0988_00634	5.289e-103	346.0	COG1653@1|root,COG1653@2|Bacteria,1TPWV@1239|Firmicutes,24AWQ@186801|Clostridia,27KF0@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Domain of unknown function (DUF3502)	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	DUF3502,SBP_bac_1,SBP_bac_8
DEZH2_k127_2299469_2	1122143.AUEG01000001_gene512	1.466e-47	173.0	COG3631@1|root,COG3631@2|Bacteria,1V898@1239|Firmicutes,4HVDM@91061|Bacilli,27GZR@186828|Carnobacteriaceae	91061|Bacilli	S	Uncharacterized conserved protein (DUF2358)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2358
DEZH2_k127_2299469_0	768704.Desmer_3316	4.206e-89	296.0	28H95@1|root,2Z7KY@2|Bacteria,1TQTR@1239|Firmicutes,24BKB@186801|Clostridia,264M7@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF4256)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4256
DEZH2_k127_2299469_1	33035.JPJF01000049_gene626	2.625e-49	182.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,24XW6@186801|Clostridia,3XYRM@572511|Blautia	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_2313787_7	1444306.JFZC01000089_gene1311	2.786e-33	130.0	COG1695@1|root,COG1695@2|Bacteria,1VA8U@1239|Firmicutes,4HKPC@91061|Bacilli,26PVE@186821|Sporolactobacillaceae	91061|Bacilli	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
DEZH2_k127_2313787_0	398512.JQKC01000030_gene4368	1.154e-271	846.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,3WGVM@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
DEZH2_k127_2313787_5	2754.EH55_13230	5.179e-46	169.0	COG1598@1|root,COG1598@2|Bacteria,3TB3Z@508458|Synergistetes	508458|Synergistetes	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
DEZH2_k127_2313787_4	755731.Clo1100_3406	4.374e-50	182.0	COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,24MUB@186801|Clostridia,36NHZ@31979|Clostridiaceae	186801|Clostridia	S	TIGRFAM C_GCAxxG_C_C family	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
DEZH2_k127_2313787_1	1121335.Clst_2020	2.839e-144	461.0	COG0207@1|root,COG0207@2|Bacteria,1TSIR@1239|Firmicutes,249QG@186801|Clostridia,3WHH9@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
DEZH2_k127_2313787_3	1232452.BAIB02000007_gene1694	2.732e-50	184.0	COG0262@1|root,COG0262@2|Bacteria,1VB80@1239|Firmicutes,24FTH@186801|Clostridia,2694W@186813|unclassified Clostridiales	186801|Clostridia	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
DEZH2_k127_2313787_8	1380763.BG53_05600	7.367e-08	65.0	COG1653@1|root,COG1653@2|Bacteria,1TYXS@1239|Firmicutes,4I83W@91061|Bacilli,26YTB@186822|Paenibacillaceae	91061|Bacilli	G	transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
DEZH2_k127_2313787_6	1392491.JIAE01000001_gene1260	7.336e-45	177.0	COG0350@1|root,COG0350@2|Bacteria,1VA03@1239|Firmicutes,24JAA@186801|Clostridia,3WS5T@541000|Ruminococcaceae	186801|Clostridia	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
DEZH2_k127_2313787_2	1410638.JHXJ01000030_gene289	9.629e-67	233.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,3WIF0@541000|Ruminococcaceae	186801|Clostridia	S	Flavin reductase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
DEZH2_k127_2330725_0	1195236.CTER_4567	1.594e-90	302.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia,3WG9R@541000|Ruminococcaceae	186801|Clostridia	C	aconitate hydratase	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
DEZH2_k127_2330725_1	509191.AEDB02000066_gene757	2.878e-37	149.0	COG1802@1|root,COG1802@2|Bacteria,1TRX1@1239|Firmicutes,25B92@186801|Clostridia,3WS4S@541000|Ruminococcaceae	186801|Clostridia	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
DEZH2_k127_2330725_2	1392491.JIAE01000001_gene1785	4.059e-15	83.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia,3WGKI@541000|Ruminococcaceae	186801|Clostridia	C	citrate synthase	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
DEZH2_k127_2330725_3	42256.RradSPS_1321	2.212e-09	66.0	COG1002@1|root,COG1002@2|Bacteria,2IA5I@201174|Actinobacteria	201174|Actinobacteria	V	Type II restriction enzyme, methylase subunits	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
DEZH2_k127_2354377_2	683837.lse_0534	6.851e-64	226.0	COG2755@1|root,COG2755@2|Bacteria,1TQEE@1239|Firmicutes,4HK3V@91061|Bacilli,26K55@186820|Listeriaceae	91061|Bacilli	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
DEZH2_k127_2354377_0	394503.Ccel_0635	2.972e-150	482.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,248TR@186801|Clostridia,36E6Q@31979|Clostridiaceae	186801|Clostridia	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	ltaE	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
DEZH2_k127_2354377_1	1499683.CCFF01000014_gene3883	4.401e-83	284.0	COG1284@1|root,COG1284@2|Bacteria,1TR9J@1239|Firmicutes,24BGW@186801|Clostridia,36DT5@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterised 5xTM membrane BCR, YitT family COG1284	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
DEZH2_k127_2354377_3	1232428.CAVO010000013_gene722	6.956e-36	144.0	COG1194@1|root,COG1194@2|Bacteria,1TPUT@1239|Firmicutes,4H1YX@909932|Negativicutes	909932|Negativicutes	L	A G-specific adenine glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
DEZH2_k127_236667_3	1195236.CTER_4338	5.306e-41	156.0	COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia,3WJ0F@541000|Ruminococcaceae	186801|Clostridia	E	Acetolactate synthase small	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
DEZH2_k127_236667_2	588581.Cpap_3957	8.835e-251	790.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3WGVP@541000|Ruminococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DEZH2_k127_236667_1	1410653.JHVC01000029_gene1164	1.089e-255	811.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,36EMB@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DEZH2_k127_236667_0	398512.JQKC01000009_gene484	0.0	1014.0	COG3968@1|root,COG3968@2|Bacteria,1UHUF@1239|Firmicutes,2481B@186801|Clostridia,3WHCK@541000|Ruminococcaceae	186801|Clostridia	S	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
DEZH2_k127_2372411_2	118005.AWNK01000005_gene1430	5.023e-53	196.0	COG5001@1|root,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,DUF4118,EAL,GGDEF,PAS_3,PAS_9
DEZH2_k127_2372411_5	765911.Thivi_0673	1.383e-35	148.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2203@1|root,COG2984@1|root,COG3290@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2984@2|Bacteria,COG3290@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K10715,ko:K20974	ko02020,ko02024,ko02025,map02020,map02024,map02025	M00517,M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
DEZH2_k127_2372411_8	441768.ACL_0673	1.75e-19	100.0	COG2199@1|root,COG3275@1|root,COG3437@1|root,COG2199@2|Bacteria,COG3275@2|Bacteria,COG3437@2|Bacteria,3WU98@544448|Tenericutes	544448|Tenericutes	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,GGDEF,HD_5,PAS_9
DEZH2_k127_2372411_1	1121324.CLIT_10c01790	1.409e-66	234.0	COG2041@1|root,COG2041@2|Bacteria,1UZMG@1239|Firmicutes,25DEZ@186801|Clostridia	186801|Clostridia	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
DEZH2_k127_2372411_0	1195236.CTER_3072	5.75e-113	370.0	COG2119@1|root,COG2119@2|Bacteria,1UFX2@1239|Firmicutes,24DHF@186801|Clostridia,3WJB8@541000|Ruminococcaceae	186801|Clostridia	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
DEZH2_k127_2372411_7	521003.COLINT_02626	1.739e-24	106.0	COG0607@1|root,COG0607@2|Bacteria,2HV5N@201174|Actinobacteria,4CWCQ@84998|Coriobacteriia	84998|Coriobacteriia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
DEZH2_k127_2372411_3	158189.SpiBuddy_0550	4.69e-50	184.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
DEZH2_k127_2372411_6	1304880.JAGB01000002_gene1832	2.558e-33	132.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia	186801|Clostridia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
DEZH2_k127_2372411_4	395494.Galf_1739	1.798e-39	156.0	COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2VN3A@28216|Betaproteobacteria,44VNG@713636|Nitrosomonadales	28216|Betaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	nnr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
DEZH2_k127_2393291_1	545695.TREAZ_0221	4.163e-49	179.0	COG0191@1|root,COG0191@2|Bacteria,2J9U8@203691|Spirochaetes	203691|Spirochaetes	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
DEZH2_k127_2393291_0	160799.PBOR_26045	4.648e-73	253.0	COG2755@1|root,COG2755@2|Bacteria,1V1CQ@1239|Firmicutes,4HGVZ@91061|Bacilli,26WB3@186822|Paenibacillaceae	91061|Bacilli	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
DEZH2_k127_2393291_2	1536774.H70357_13405	3.559e-41	157.0	COG4799@1|root,COG4799@2|Bacteria,1TSPB@1239|Firmicutes,4HAM5@91061|Bacilli,26VD4@186822|Paenibacillaceae	91061|Bacilli	I	Malonate decarboxylase gamma subunit (MdcE)	mdcD	-	4.1.1.87	ko:K13932	-	-	-	-	ko00000,ko01000	-	-	-	Carboxyl_trans,MdcE
DEZH2_k127_2398714_0	1410638.JHXJ01000013_gene2281	8.496e-49	179.0	COG0749@1|root,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,3WGRT@541000|Ruminococcaceae	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
DEZH2_k127_2398714_4	1120999.JONM01000002_gene540	4.398e-08	64.0	COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2VSSM@28216|Betaproteobacteria	28216|Betaproteobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
DEZH2_k127_2398714_1	457570.Nther_1894	8.433e-36	145.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DEZH2_k127_2398714_3	1235798.C817_02795	1.623e-21	102.0	COG4720@1|root,COG4720@2|Bacteria,1VBJP@1239|Firmicutes,25CJQ@186801|Clostridia,27VIN@189330|Dorea	186801|Clostridia	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
DEZH2_k127_2398714_2	1121448.DGI_0976	1.714e-24	104.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2WQ6E@28221|Deltaproteobacteria,2MCM3@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
DEZH2_k127_2416779_1	537013.CLOSTMETH_00739	8.648e-89	298.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,25E48@186801|Clostridia,3WHD3@541000|Ruminococcaceae	186801|Clostridia	I	acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
DEZH2_k127_2416779_2	195103.CPF_1329	4.338e-47	173.0	COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,24JAW@186801|Clostridia,36IPJ@31979|Clostridiaceae	186801|Clostridia	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
DEZH2_k127_2416779_3	398527.Bphyt_3426	1.299e-27	117.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2VR5S@28216|Betaproteobacteria,1K707@119060|Burkholderiaceae	28216|Betaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
DEZH2_k127_2416779_0	760568.Desku_2292	3.794e-153	495.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,2602N@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
DEZH2_k127_2443250_4	665956.HMPREF1032_01728	4.34e-16	81.0	COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,24JVM@186801|Clostridia,3WKJX@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfG	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
DEZH2_k127_2443250_2	1120746.CCNL01000014_gene2076	3.733e-75	260.0	COG4660@1|root,COG4660@2|Bacteria,2NP80@2323|unclassified Bacteria	2|Bacteria	U	Part of a membrane complex involved in electron transport	rnfE	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944	2.3.1.243,4.2.99.18	ko:K02560,ko:K03613,ko:K10773	ko00540,ko01100,ko03410,map00540,map01100,map03410	M00060	R05075	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005,ko03400	-	-	iHN637.CLJU_RS05585	Rnf-Nqr
DEZH2_k127_2443250_3	1507.HMPREF0262_00233	4.762e-71	245.0	COG4657@1|root,COG4657@2|Bacteria,1TS06@1239|Firmicutes,247UE@186801|Clostridia,36ESS@31979|Clostridiaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
DEZH2_k127_2443250_1	203119.Cthe_2435	7.378e-78	269.0	COG1142@1|root,COG2878@1|root,COG1142@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,24904@186801|Clostridia,3WIFS@541000|Ruminococcaceae	186801|Clostridia	C	electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_13,Fer4_4,Fer4_9
DEZH2_k127_2443250_0	1042156.CXIVA_13860	2.406e-126	421.0	COG2801@1|root,COG2801@2|Bacteria,1TQQY@1239|Firmicutes,2487W@186801|Clostridia,36W78@31979|Clostridiaceae	186801|Clostridia	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_2
DEZH2_k127_2448898_4	1163671.JAGI01000002_gene2286	0.000105	50.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,36EYT@31979|Clostridiaceae	186801|Clostridia	G	Glycosyltransferase 36 associated	ndvB	-	-	-	-	-	-	-	-	-	-	-	DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase
DEZH2_k127_2448898_0	1121335.Clst_0740	2.14e-101	343.0	COG0438@1|root,COG0438@2|Bacteria,1UBCE@1239|Firmicutes,24DYC@186801|Clostridia	186801|Clostridia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DEZH2_k127_2448898_2	608506.COB47_0985	1.778e-38	150.0	COG0778@1|root,COG0778@2|Bacteria,1V1BQ@1239|Firmicutes,25B0F@186801|Clostridia,42GTE@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DEZH2_k127_2448898_1	1123514.KB905899_gene1163	2.276e-43	162.0	COG3743@1|root,COG3743@2|Bacteria,1RA3K@1224|Proteobacteria,1S9SF@1236|Gammaproteobacteria,462QA@72273|Thiotrichales	72273|Thiotrichales	S	Domain of unknown function (DUF4332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332
DEZH2_k127_2448898_3	871963.Desdi_0610	4.425e-06	49.0	COG1122@1|root,COG1122@2|Bacteria,1TSSM@1239|Firmicutes,249KS@186801|Clostridia,2602Q@186807|Peptococcaceae	186801|Clostridia	P	ABC-type cobalt transport system ATPase component	cbiO	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
DEZH2_k127_2461065_0	1122169.AREN01000019_gene2040	1.324e-21	106.0	COG2207@1|root,COG2207@2|Bacteria,1RH01@1224|Proteobacteria,1S57M@1236|Gammaproteobacteria,1JCMN@118969|Legionellales	118969|Legionellales	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
DEZH2_k127_2461065_1	626887.J057_12876	1.777e-07	56.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RMA9@1236|Gammaproteobacteria,46AM5@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
DEZH2_k127_2461150_0	1392491.JIAE01000001_gene2344	1.501e-55	214.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	lacM	-	3.2.1.23,3.2.1.35,3.2.1.51,3.2.1.97	ko:K01190,ko:K01197,ko:K01206,ko:K17624	ko00052,ko00511,ko00531,ko00600,ko01100,map00052,map00511,map00531,map00600,map01100	M00076,M00077	R01105,R01678,R03355,R04783,R06114,R07824,R07825,R10905	RC00049,RC00452	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042,ko04147	-	GH101,GH29	-	Bgal_small_N,DUF5011,F5_F8_type_C,Glyco_hydro_2_C,NPCBM,Peptidase_M60
DEZH2_k127_2461150_1	1280390.CBQR020000039_gene860	5.088e-31	125.0	COG0602@1|root,COG0602@2|Bacteria,1V1HG@1239|Firmicutes,4HMKT@91061|Bacilli,26UQF@186822|Paenibacillaceae	91061|Bacilli	O	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	nrdG	-	1.97.1.4	ko:K04068	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
DEZH2_k127_2465985_7	1304880.JAGB01000001_gene575	3.132e-40	156.0	COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia	186801|Clostridia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
DEZH2_k127_2465985_3	509191.AEDB02000108_gene1523	6.635e-104	345.0	COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,248CQ@186801|Clostridia,3WGC5@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
DEZH2_k127_2465985_4	398512.JQKC01000024_gene3187	2.734e-80	276.0	COG0461@1|root,COG0461@2|Bacteria,1TS3K@1239|Firmicutes,24D7Z@186801|Clostridia,3WICY@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	-
DEZH2_k127_2465985_8	411462.DORLON_02946	1.574e-28	122.0	COG1451@1|root,COG1451@2|Bacteria,1V6WP@1239|Firmicutes,24JGH@186801|Clostridia,27VP1@189330|Dorea	186801|Clostridia	S	WLM domain	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
DEZH2_k127_2465985_6	694427.Palpr_2079	1.069e-57	211.0	COG0300@1|root,COG0300@2|Bacteria,4PKR6@976|Bacteroidetes,2G0WN@200643|Bacteroidia	976|Bacteroidetes	S	Fungal family of unknown function (DUF1776)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
DEZH2_k127_2465985_1	699246.HMPREF0868_0882	7.488e-177	569.0	COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,2482Y@186801|Clostridia,267K9@186813|unclassified Clostridiales	186801|Clostridia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
DEZH2_k127_2465985_0	398512.JQKC01000013_gene1366	1.917e-321	1007.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,3WGM4@541000|Ruminococcaceae	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
DEZH2_k127_2465985_2	398512.JQKC01000013_gene1365	1.073e-141	469.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,3WHC5@541000|Ruminococcaceae	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
DEZH2_k127_2465985_5	1304880.JAGB01000001_gene246	1.567e-79	274.0	COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia	186801|Clostridia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
DEZH2_k127_2487753_1	1280664.AUIX01000008_gene3211	2.315e-70	246.0	COG0635@1|root,COG0635@2|Bacteria,1TREM@1239|Firmicutes,247JT@186801|Clostridia,4BX6Z@830|Butyrivibrio	186801|Clostridia	H	Elongator protein 3, MiaB family, Radical SAM	hemZ	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DEZH2_k127_2487753_2	1111454.HMPREF1250_0993	1.273e-07	63.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,4H466@909932|Negativicutes	909932|Negativicutes	T	phosphatase	prpC	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
DEZH2_k127_2487753_3	1321778.HMPREF1982_02335	5.062e-07	57.0	arCOG13226@1|root,32BWE@2|Bacteria,1UGHD@1239|Firmicutes,24X70@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2487753_0	720554.Clocl_1048	0.0	1215.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,3WG9B@541000|Ruminococcaceae	186801|Clostridia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
DEZH2_k127_2496646_3	1410632.JHWW01000001_gene929	6.293e-32	126.0	COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,27IVF@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
DEZH2_k127_2496646_1	699246.HMPREF0868_1160	7.775e-86	295.0	COG0564@1|root,COG0564@2|Bacteria,1TR1M@1239|Firmicutes,248W3@186801|Clostridia,267R6@186813|unclassified Clostridiales	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
DEZH2_k127_2496646_0	699246.HMPREF0868_0353	8.022e-97	329.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia	186801|Clostridia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.1.2.1,6.3.2.35,6.3.2.4	ko:K01921,ko:K15739,ko:K18856	ko00473,ko00550,ko01100,ko01502,ko02020,map00473,map00550,map01100,map01502,map02020	M00651,M00652	R01150,R09588	RC00037,RC00064,RC00094,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko01504	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
DEZH2_k127_2496646_2	1392491.JIAE01000001_gene654	3.606e-79	271.0	COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,3WGBW@541000|Ruminococcaceae	186801|Clostridia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
DEZH2_k127_25122_1	1304880.JAGB01000002_gene1915	3.754e-93	319.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DEZH2_k127_25122_0	315749.Bcer98_3965	3.667e-153	490.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,4H9U5@91061|Bacilli,1ZB5V@1386|Bacillus	91061|Bacilli	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
DEZH2_k127_2520080_0	1280668.ATVT01000011_gene3303	7.355e-211	665.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,4BXM3@830|Butyrivibrio	186801|Clostridia	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
DEZH2_k127_2523679_0	555088.DealDRAFT_0819	1.839e-173	577.0	COG2273@1|root,COG5337@1|root,COG2273@2|Bacteria,COG5337@2|Bacteria,1TRAW@1239|Firmicutes,24AQY@186801|Clostridia	186801|Clostridia	M	PFAM Spore coat protein CotH	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Dockerin_1,Fn3_assoc,LTD
DEZH2_k127_2523679_1	935845.JADQ01000064_gene73	1.008e-53	198.0	COG5036@1|root,COG5036@2|Bacteria,1TYFN@1239|Firmicutes,4HE77@91061|Bacilli,274W1@186822|Paenibacillaceae	91061|Bacilli	P	VTC domain	-	-	-	-	-	-	-	-	-	-	-	-	VTC
DEZH2_k127_2523679_2	1128398.Curi_c25020	1.181e-46	175.0	COG1285@1|root,COG1285@2|Bacteria,1TRUW@1239|Firmicutes,248G4@186801|Clostridia,26AYT@186813|unclassified Clostridiales	186801|Clostridia	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
DEZH2_k127_2523679_3	140626.JHWB01000013_gene310	1.97e-31	126.0	COG3862@1|root,COG3862@2|Bacteria,1VA4U@1239|Firmicutes,24MN9@186801|Clostridia	186801|Clostridia	S	protein with conserved CXXC pairs	-	-	-	-	-	-	-	-	-	-	-	-	DUF1667
DEZH2_k127_2532220_3	588581.Cpap_2107	8.212e-26	113.0	COG1247@1|root,COG1247@2|Bacteria,1V6X5@1239|Firmicutes,24IB5@186801|Clostridia	186801|Clostridia	M	Acetyltransferase GNAT family	yncA	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
DEZH2_k127_2532220_0	1410638.JHXJ01000013_gene2277	4.908e-214	680.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia,3WGCZ@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,HTH_18,LeuA_dimer
DEZH2_k127_2532220_1	1121472.AQWN01000011_gene1206	2.619e-85	294.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,261SM@186807|Peptococcaceae	186801|Clostridia	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02525,ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
DEZH2_k127_2532220_2	1232443.BAIA02000110_gene2600	1.98e-48	180.0	COG2267@1|root,COG2267@2|Bacteria,1TRM1@1239|Firmicutes,247J5@186801|Clostridia,268F2@186813|unclassified Clostridiales	186801|Clostridia	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Peptidase_S9
DEZH2_k127_2540451_1	588581.Cpap_0535	1.486e-45	171.0	COG1022@1|root,COG1022@2|Bacteria,1TS22@1239|Firmicutes,24AZW@186801|Clostridia,3WHKE@541000|Ruminococcaceae	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
DEZH2_k127_2540451_0	1321784.HMPREF1987_00924	3.754e-52	197.0	COG1597@1|root,COG1597@2|Bacteria,1V1DP@1239|Firmicutes,24K52@186801|Clostridia	186801|Clostridia	I	lipid kinase, YegS Rv2252 BmrU family	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
DEZH2_k127_2567288_2	1536775.H70737_10635	2.323e-61	215.0	COG0110@1|root,COG0110@2|Bacteria,1V06U@1239|Firmicutes,4HVWV@91061|Bacilli,26TK8@186822|Paenibacillaceae	91061|Bacilli	S	Maltose acetyltransferase	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Mac
DEZH2_k127_2567288_0	573061.Clocel_0284	6.059e-98	327.0	arCOG06802@1|root,335UQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2567288_3	285535.JOEY01000090_gene7679	1.525e-24	111.0	2EXVQ@1|root,33R4U@2|Bacteria,2IDZ0@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
DEZH2_k127_2567288_1	697284.ERIC2_c29850	1.123e-93	310.0	COG4813@1|root,COG4813@2|Bacteria,1TPZ1@1239|Firmicutes,4HARS@91061|Bacilli,26S59@186822|Paenibacillaceae	91061|Bacilli	G	Trehalose utilization protein	thuA	-	-	-	-	-	-	-	-	-	-	-	ThuA
DEZH2_k127_2572625_4	697284.ERIC2_c35240	1.483e-21	104.0	COG0671@1|root,COG0671@2|Bacteria,1V2ZH@1239|Firmicutes,4HMGP@91061|Bacilli,26XGP@186822|Paenibacillaceae	91061|Bacilli	I	COG0671 Membrane-associated phospholipid phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
DEZH2_k127_2572625_3	1444309.JAQG01000152_gene4361	1.262e-43	166.0	COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,4HH7S@91061|Bacilli,26WR2@186822|Paenibacillaceae	91061|Bacilli	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
DEZH2_k127_2572625_1	632292.Calhy_2341	1.024e-78	268.0	COG0637@1|root,COG0637@2|Bacteria,1UZE0@1239|Firmicutes,24DWR@186801|Clostridia,42JEI@68295|Thermoanaerobacterales	186801|Clostridia	S	HAD-superfamily hydrolase, subfamily IA, variant 3	pgmB	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
DEZH2_k127_2572625_0	1122919.KB905569_gene2971	3.833e-237	745.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,4HBDB@91061|Bacilli,26TD5@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
DEZH2_k127_2572625_2	720554.Clocl_1494	1.008e-44	166.0	COG2519@1|root,COG2519@2|Bacteria,1V6VU@1239|Firmicutes,24JEE@186801|Clostridia,3WIXW@541000|Ruminococcaceae	186801|Clostridia	J	Putative rRNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	rRNA_methylase
DEZH2_k127_2582445_3	867903.ThesuDRAFT_01161	3.852e-05	47.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,3WCY5@538999|Clostridiales incertae sedis	186801|Clostridia	U	Binding-protein-dependent transport system inner membrane component	oppB	-	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
DEZH2_k127_2582445_0	526218.Sterm_3851	2.014e-121	408.0	COG4166@1|root,COG4166@2|Bacteria,379CV@32066|Fusobacteria	32066|Fusobacteria	E	ABC transporter, substrate-binding protein, family 5	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
DEZH2_k127_2582445_1	588581.Cpap_1900	3.241e-82	278.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,3WHNZ@541000|Ruminococcaceae	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
DEZH2_k127_2582445_2	1291050.JAGE01000001_gene1911	5.082e-27	113.0	COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,3WJW1@541000|Ruminococcaceae	186801|Clostridia	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
DEZH2_k127_2587265_2	1392491.JIAE01000001_gene1072	2.416e-66	242.0	COG2234@1|root,COG2234@2|Bacteria,1UVEY@1239|Firmicutes,2588N@186801|Clostridia,3WMA7@541000|Ruminococcaceae	186801|Clostridia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
DEZH2_k127_2587265_1	1121428.DESHY_160013___1	2.112e-89	308.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,260TE@186807|Peptococcaceae	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
DEZH2_k127_2587265_0	1392491.JIAE01000001_gene958	6.653e-127	416.0	COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,3WI1X@541000|Ruminococcaceae	186801|Clostridia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
DEZH2_k127_2587265_4	632518.Calow_1330	2.818e-36	144.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,42GBG@68295|Thermoanaerobacterales	186801|Clostridia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
DEZH2_k127_2587265_3	1226322.HMPREF1545_01333	6.949e-46	168.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,2N6EU@216572|Oscillospiraceae	186801|Clostridia	O	MreB/Mbl protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
DEZH2_k127_2621216_1	1410638.JHXJ01000002_gene1364	2.018e-117	382.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,3WGJK@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
DEZH2_k127_2621216_2	720554.Clocl_1443	9.896e-85	291.0	COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia,3WIME@541000|Ruminococcaceae	186801|Clostridia	O	PFAM AIR synthase related protein	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
DEZH2_k127_2621216_0	1410638.JHXJ01000002_gene1362	1.439e-130	427.0	COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia,3WGMK@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
DEZH2_k127_2621216_3	1458462.JNLK01000001_gene2295	1.16e-44	169.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,27IC3@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Aminotransferase class-V	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
DEZH2_k127_262922_2	1321778.HMPREF1982_00895	7.292e-40	166.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,26ADQ@186813|unclassified Clostridiales	186801|Clostridia	T	Psort location Cytoplasmic, score 9.97	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
DEZH2_k127_262922_3	397287.C807_03227	5.927e-34	144.0	COG1172@1|root,COG1172@2|Bacteria,1V9PU@1239|Firmicutes,24PGN@186801|Clostridia,27TI1@186928|unclassified Lachnospiraceae	186801|Clostridia	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_262922_4	1123250.KB908406_gene1975	1.644e-30	135.0	COG1609@1|root,COG1609@2|Bacteria,1TQIU@1239|Firmicutes	1239|Firmicutes	K	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
DEZH2_k127_262922_1	397287.C807_03229	4.891e-48	187.0	COG1172@1|root,COG1172@2|Bacteria,1U0FI@1239|Firmicutes,24B5S@186801|Clostridia,27J2Q@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
DEZH2_k127_262922_0	397287.C807_00562	3.275e-158	513.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,27IA2@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
DEZH2_k127_2634751_0	1123308.KB904546_gene1550	1.315e-120	392.0	COG2313@1|root,COG2313@2|Bacteria,1TR5J@1239|Firmicutes,4HC38@91061|Bacilli	91061|Bacilli	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
DEZH2_k127_2634751_5	1041522.MCOL_V216469	2.545e-20	95.0	COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria,23AQX@1762|Mycobacteriaceae	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
DEZH2_k127_2634751_2	1408445.JHXP01000006_gene139	1.85e-71	246.0	COG0431@1|root,COG0431@2|Bacteria,1RAFI@1224|Proteobacteria,1S3MG@1236|Gammaproteobacteria,1JDG0@118969|Legionellales	118969|Legionellales	S	Flavodoxin-like fold	yieF	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
DEZH2_k127_2634751_6	357809.Cphy_0801	1.547e-17	87.0	COG4892@1|root,COG4892@2|Bacteria,1VPPE@1239|Firmicutes,24KBV@186801|Clostridia	186801|Clostridia	S	Cytochrome b5	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2634751_3	411483.FAEPRAA2165_01168	2.045e-55	201.0	COG2755@1|root,COG2755@2|Bacteria,1V1CQ@1239|Firmicutes,24G68@186801|Clostridia,3WS1K@541000|Ruminococcaceae	186801|Clostridia	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
DEZH2_k127_2634751_4	1408323.JQKK01000007_gene805	9.714e-42	168.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1UNTF@1239|Firmicutes,248YN@186801|Clostridia,27M1Y@186928|unclassified Lachnospiraceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
DEZH2_k127_2634751_1	632292.Calhy_2347	7.258e-95	319.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia	186801|Clostridia	G	import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
DEZH2_k127_2638626_6	1123303.AQVD01000001_gene618	1.788e-10	62.0	COG2755@1|root,COG2755@2|Bacteria,1VB88@1239|Firmicutes,4HKEW@91061|Bacilli	91061|Bacilli	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Lipase_GDSL_2
DEZH2_k127_2638626_2	504472.Slin_4020	1.339e-79	278.0	COG0657@1|root,COG0657@2|Bacteria,4NIQ0@976|Bacteroidetes,47JK6@768503|Cytophagia	976|Bacteroidetes	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
DEZH2_k127_2638626_5	1286171.EAL2_808p04280	3.354e-22	97.0	COG3360@1|root,COG3360@2|Bacteria	2|Bacteria	P	Dodecin	secE2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
DEZH2_k127_2638626_3	428125.CLOLEP_00221	7.238e-53	199.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,2493B@186801|Clostridia,3WPQQ@541000|Ruminococcaceae	186801|Clostridia	M	YceG-like family	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
DEZH2_k127_2638626_4	646529.Desaci_1641	1.202e-37	144.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia	186801|Clostridia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
DEZH2_k127_2638626_0	699246.HMPREF0868_0868	1.791e-145	468.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,267PJ@186813|unclassified Clostridiales	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
DEZH2_k127_2638626_1	1469948.JPNB01000001_gene1871	2.972e-82	283.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,36EW8@31979|Clostridiaceae	186801|Clostridia	S	basic membrane	tmpC	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
DEZH2_k127_2646329_1	589865.DaAHT2_0107	6.444e-67	231.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42NKD@68525|delta/epsilon subdivisions,2WIWV@28221|Deltaproteobacteria,2MIVW@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1825	AMP-binding,AMP-binding_C_2
DEZH2_k127_2646329_2	1009370.ALO_06478	8.104e-55	207.0	COG0204@1|root,COG0204@2|Bacteria,1V11X@1239|Firmicutes	1239|Firmicutes	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
DEZH2_k127_2646329_0	203119.Cthe_1955	6.633e-206	653.0	COG2183@1|root,COG2183@2|Bacteria,1TPFE@1239|Firmicutes,248P0@186801|Clostridia,3WGWI@541000|Ruminococcaceae	186801|Clostridia	K	Tex-like protein N-terminal domain	yhgF	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
DEZH2_k127_2649318_3	398512.JQKC01000007_gene1028	4.495e-103	343.0	COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,3WHBB@541000|Ruminococcaceae	186801|Clostridia	J	phenylalanyl-tRNA synthetase (beta subunit)	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
DEZH2_k127_2649318_2	1392491.JIAE01000001_gene1379	1.716e-161	516.0	COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,3WGWV@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
DEZH2_k127_2649318_7	1378168.N510_03039	2.63e-06	59.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40
DEZH2_k127_2649318_6	138119.DSY2449	7.091e-37	147.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia,261Y2@186807|Peptococcaceae	186801|Clostridia	P	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DEZH2_k127_2649318_4	1122221.JHVI01000007_gene2237	3.556e-50	183.0	COG1490@1|root,COG1490@2|Bacteria,1WJUX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
DEZH2_k127_2649318_0	398512.JQKC01000002_gene1674	6.097e-234	729.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,3WGP0@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
DEZH2_k127_2649318_5	699246.HMPREF0868_1098	7.036e-42	157.0	COG1803@1|root,COG1803@2|Bacteria	2|Bacteria	G	methylglyoxal synthase activity	mgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576	2.7.1.24,4.2.3.3	ko:K00859,ko:K01734	ko00640,ko00770,ko01100,ko01120,map00640,map00770,map01100,map01120	M00120	R00130,R01016	RC00002,RC00078,RC00424	ko00000,ko00001,ko00002,ko01000	-	-	-	MGS
DEZH2_k127_2649318_1	1392491.JIAE01000001_gene1376	3.314e-163	530.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia,3WGCH@541000|Ruminococcaceae	186801|Clostridia	M	Penicillin-binding protein, transpeptidase domain protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
DEZH2_k127_2652192_1	755731.Clo1100_1230	7.617e-37	141.0	COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,24MX9@186801|Clostridia,36KY4@31979|Clostridiaceae	186801|Clostridia	S	protein, YerC YecD	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
DEZH2_k127_2652192_0	699246.HMPREF0868_1091	7.565e-229	716.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,267T4@186813|unclassified Clostridiales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
DEZH2_k127_2659139_0	522306.CAP2UW1_3740	7.131e-178	564.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_32
DEZH2_k127_2659139_1	1121035.AUCH01000001_gene1792	5.767e-16	78.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,2KVRV@206389|Rhodocyclales	206389|Rhodocyclales	T	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
DEZH2_k127_2674094_2	877415.JNJQ01000002_gene2287	8.154e-82	285.0	COG1172@1|root,COG1172@2|Bacteria,1V9PU@1239|Firmicutes	1239|Firmicutes	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_2674094_4	1121115.AXVN01000103_gene857	1.783e-19	102.0	COG1609@1|root,COG1609@2|Bacteria,1UZFZ@1239|Firmicutes,24H13@186801|Clostridia	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2674094_1	877415.JNJQ01000002_gene2285	1.438e-92	314.0	COG1172@1|root,COG1172@2|Bacteria,1U0FI@1239|Firmicutes	1239|Firmicutes	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_2674094_0	877415.JNJQ01000002_gene2284	1.764e-209	661.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,3VUVP@526524|Erysipelotrichia	1239|Firmicutes	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
DEZH2_k127_2674094_3	180332.JTGN01000015_gene1089	2.515e-34	143.0	COG2207@1|root,COG2207@2|Bacteria,1V28B@1239|Firmicutes,24GF0@186801|Clostridia	186801|Clostridia	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC
DEZH2_k127_267542_1	1304284.L21TH_0351	1.283e-86	297.0	COG0477@1|root,COG2814@2|Bacteria,1TQDU@1239|Firmicutes,25ESY@186801|Clostridia,36V3T@31979|Clostridiaceae	186801|Clostridia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,PUCC,Sugar_tr
DEZH2_k127_267542_0	189425.PGRAT_25820	2.694e-116	381.0	COG2321@1|root,COG2321@2|Bacteria,1TQKF@1239|Firmicutes,4HB7I@91061|Bacilli,26U6Z@186822|Paenibacillaceae	91061|Bacilli	S	Metalloprotease	XK27_03670	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
DEZH2_k127_267542_3	1096546.WYO_0122	9.198e-22	104.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,2TRK0@28211|Alphaproteobacteria,1JQRH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	oxidoreductase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
DEZH2_k127_267542_4	515635.Dtur_0291	1.707e-16	84.0	COG0679@1|root,COG0679@2|Bacteria	2|Bacteria	S	auxin-activated signaling pathway	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
DEZH2_k127_2680221_0	742733.HMPREF9469_02823	1.855e-146	469.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,21XXY@1506553|Lachnoclostridium	186801|Clostridia	C	NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
DEZH2_k127_2680221_1	1125712.HMPREF1316_1084	2.475e-39	149.0	COG1917@1|root,COG1917@2|Bacteria,2I46U@201174|Actinobacteria	201174|Actinobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
DEZH2_k127_2686595_3	1487921.DP68_08295	3.974e-14	73.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia,36IU5@31979|Clostridiaceae	186801|Clostridia	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
DEZH2_k127_2686595_1	1209989.TepiRe1_1654	3.832e-59	213.0	COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia,42EWM@68295|Thermoanaerobacterales	186801|Clostridia	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
DEZH2_k127_2686595_0	1392491.JIAE01000001_gene1374	1.697e-62	225.0	COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia,3WKDC@541000|Ruminococcaceae	186801|Clostridia	M	rod shape-determining protein MreC	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
DEZH2_k127_2686595_2	1392491.JIAE01000001_gene1376	1.173e-23	110.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia,3WGCH@541000|Ruminococcaceae	186801|Clostridia	M	Penicillin-binding protein, transpeptidase domain protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
DEZH2_k127_269201_1	1158607.UAU_00923	1.943e-47	178.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,4HTTR@91061|Bacilli,4B4J7@81852|Enterococcaceae	91061|Bacilli	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
DEZH2_k127_269201_0	573061.Clocel_2508	1.736e-77	269.0	COG2207@1|root,COG2207@2|Bacteria,1V4GS@1239|Firmicutes,24HHT@186801|Clostridia,36M0D@31979|Clostridiaceae	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
DEZH2_k127_2703476_6	929506.CbC4_2233	0.0003352	48.0	COG2059@1|root,COG2059@2|Bacteria,1V43H@1239|Firmicutes,24JTX@186801|Clostridia,36IGJ@31979|Clostridiaceae	186801|Clostridia	P	Chromate transport protein	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
DEZH2_k127_2703476_2	1121335.Clst_0706	5.607e-57	205.0	COG2059@1|root,COG2059@2|Bacteria,1V42U@1239|Firmicutes,24HA0@186801|Clostridia,3WJYR@541000|Ruminococcaceae	186801|Clostridia	P	Psort location CytoplasmicMembrane, score	chrA2	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
DEZH2_k127_2703476_1	665956.HMPREF1032_00456	6.974e-145	473.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3WH49@541000|Ruminococcaceae	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	MatE
DEZH2_k127_2703476_4	1232453.BAIF02000098_gene3874	5.739e-48	180.0	COG2755@1|root,COG2755@2|Bacteria,1VB88@1239|Firmicutes,24NGQ@186801|Clostridia	186801|Clostridia	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
DEZH2_k127_2703476_5	1298920.KI911353_gene4686	9.584e-11	74.0	2DNHB@1|root,32XHV@2|Bacteria,1VAWM@1239|Firmicutes,25DB0@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2703476_0	1033810.HLPCO_001765	6.607e-178	572.0	COG3507@1|root,COG3507@2|Bacteria,2NQ5H@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolases family 43	xynB	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	DUF1349,Glyco_hydro_43
DEZH2_k127_2703476_3	657322.FPR_17820	4.659e-53	204.0	COG0657@1|root,COG0657@2|Bacteria,1UEU5@1239|Firmicutes,24BRQ@186801|Clostridia	2|Bacteria	I	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
DEZH2_k127_2712355_2	509191.AEDB02000099_gene3963	1.487e-08	56.0	COG1108@1|root,COG1108@2|Bacteria,1TR79@1239|Firmicutes,24875@186801|Clostridia,3WIIH@541000|Ruminococcaceae	186801|Clostridia	P	ABC-type Mn2 Zn2 transport	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
DEZH2_k127_2712355_1	485916.Dtox_0334	6.933e-60	216.0	COG1121@1|root,COG1121@2|Bacteria,1TQJ3@1239|Firmicutes,25B2N@186801|Clostridia,260VF@186807|Peptococcaceae	186801|Clostridia	P	ABC transporter	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
DEZH2_k127_2712355_0	1256908.HMPREF0373_03455	3.366e-69	250.0	2EY82@1|root,33RGJ@2|Bacteria,1VRAX@1239|Firmicutes,24YSC@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2723621_5	1303518.CCALI_02189	8.451e-59	211.0	COG0118@1|root,COG0118@2|Bacteria	2|Bacteria	E	glutamine metabolic process	hisH	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
DEZH2_k127_2723621_6	697281.Mahau_0268	8.997e-59	215.0	COG0106@1|root,COG0106@2|Bacteria,1V1IR@1239|Firmicutes,24GBJ@186801|Clostridia,42G05@68295|Thermoanaerobacterales	186801|Clostridia	E	TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
DEZH2_k127_2723621_1	1089553.Tph_c08870	1.616e-102	346.0	COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,42FAR@68295|Thermoanaerobacterales	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05755	His_biosynth
DEZH2_k127_2723621_9	203119.Cthe_2889	5.214e-34	132.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1UYNA@1239|Firmicutes,247RS@186801|Clostridia,3WJ30@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05760	His_biosynth,PRA-CH,PRA-PH
DEZH2_k127_2723621_10	398512.JQKC01000005_gene5344	2.098e-22	97.0	COG0267@1|root,COG0267@2|Bacteria,1VEJ4@1239|Firmicutes,24QK0@186801|Clostridia,3WKQN@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
DEZH2_k127_2723621_12	699246.HMPREF0868_1277	2.074e-05	52.0	COG0690@1|root,COG0690@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
DEZH2_k127_2723621_2	699246.HMPREF0868_1276	5.144e-87	289.0	COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,248XB@186801|Clostridia,26860@186813|unclassified Clostridiales	186801|Clostridia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
DEZH2_k127_2723621_4	699246.HMPREF0868_1275	1.153e-70	241.0	COG0080@1|root,COG0080@2|Bacteria,1V1BS@1239|Firmicutes,24FSQ@186801|Clostridia,268Y4@186813|unclassified Clostridiales	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
DEZH2_k127_2723621_0	1392491.JIAE01000001_gene2507	5.372e-118	382.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,247JB@186801|Clostridia,3WH4A@541000|Ruminococcaceae	186801|Clostridia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
DEZH2_k127_2723621_7	699246.HMPREF0868_1273	1.171e-49	184.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,268RU@186813|unclassified Clostridiales	186801|Clostridia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
DEZH2_k127_2723621_8	699246.HMPREF0868_1272	8.469e-44	163.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia,269AI@186813|unclassified Clostridiales	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
DEZH2_k127_2723621_3	574087.Acear_0858	2.932e-72	261.0	COG0675@1|root,COG0675@2|Bacteria,1TQAH@1239|Firmicutes,249JS@186801|Clostridia,3WCA2@53433|Halanaerobiales	186801|Clostridia	L	TIGRFAM transposase, IS605 OrfB family, central region	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
DEZH2_k127_2723621_11	509191.AEDB02000028_gene2901	4.415e-15	75.0	2EFGV@1|root,3399G@2|Bacteria,1U5Y2@1239|Firmicutes,24WP5@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_275570_2	1232453.BAIF02000062_gene1894	1.586e-15	79.0	COG0407@1|root,COG0407@2|Bacteria,1UZTT@1239|Firmicutes,24E86@186801|Clostridia	1232453.BAIF02000062_gene1894|-	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_275570_0	180332.JTGN01000016_gene985	4.212e-60	225.0	28MXM@1|root,2ZB4M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_275570_1	1232453.BAIF02000031_gene2556	1.242e-34	136.0	COG4952@1|root,COG4952@2|Bacteria,1UD8H@1239|Firmicutes,24HDU@186801|Clostridia	186801|Clostridia	G	isomerase	-	-	5.3.1.14	ko:K01820	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01906,R02437,R06589	RC00376,RC00434,RC00516	ko00000,ko00001,ko01000	-	-	-	-
DEZH2_k127_276443_0	1511.CLOST_2430	1.348e-20	103.0	COG4219@1|root,COG4219@2|Bacteria,1VISW@1239|Firmicutes,24PPN@186801|Clostridia	186801|Clostridia	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	YARHG
DEZH2_k127_276443_1	552398.HMPREF0866_01758	1.436e-16	80.0	COG0846@1|root,COG0846@2|Bacteria,1TQKD@1239|Firmicutes,2491J@186801|Clostridia,3WGSY@541000|Ruminococcaceae	186801|Clostridia	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
DEZH2_k127_2808247_2	1163671.JAGI01000002_gene971	7.073e-17	80.0	COG1028@1|root,COG1028@2|Bacteria,1TUP6@1239|Firmicutes,24AU9@186801|Clostridia,36HJV@31979|Clostridiaceae	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
DEZH2_k127_2808247_0	903818.KI912268_gene2109	5.194e-117	384.0	COG1250@1|root,COG1250@2|Bacteria,3Y3S5@57723|Acidobacteria	57723|Acidobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
DEZH2_k127_2808247_1	768706.Desor_2360	7.892e-107	347.0	COG1878@1|root,COG1878@2|Bacteria,1TT6T@1239|Firmicutes,24CVX@186801|Clostridia	186801|Clostridia	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
DEZH2_k127_2835704_3	1121334.KB911081_gene431	7.944e-36	138.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia,3WGZC@541000|Ruminococcaceae	186801|Clostridia	E	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
DEZH2_k127_2835704_1	720554.Clocl_2211	3.987e-93	310.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,248BR@186801|Clostridia	186801|Clostridia	K	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_2835704_0	398512.JQKC01000008_gene938	2.091e-131	433.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3WN3N@541000|Ruminococcaceae	186801|Clostridia	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
DEZH2_k127_2835704_2	1304866.K413DRAFT_4364	3.328e-48	178.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,36DJE@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
DEZH2_k127_2836006_3	1126627.BAWE01000004_gene4118	3.383e-05	49.0	COG1396@1|root,COG1396@2|Bacteria,1PX03@1224|Proteobacteria,2U2AW@28211|Alphaproteobacteria,3JW08@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,PilZ
DEZH2_k127_2836006_0	1301100.HG529263_gene672	2.444e-136	448.0	COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,36DVM@31979|Clostridiaceae	186801|Clostridia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
DEZH2_k127_2836006_1	1226322.HMPREF1545_01193	1.074e-128	421.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,2N6V5@216572|Oscillospiraceae	186801|Clostridia	L	helicase superfamily c-terminal domain	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
DEZH2_k127_2836006_2	756499.Desde_0329	3.065e-110	369.0	COG4826@1|root,COG4826@2|Bacteria,1UYKX@1239|Firmicutes,24B76@186801|Clostridia,260NR@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
DEZH2_k127_2857740_0	1122925.KB895378_gene2568	2.141e-167	534.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,4HF7I@91061|Bacilli,26TFY@186822|Paenibacillaceae	91061|Bacilli	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
DEZH2_k127_2857740_2	445973.CLOBAR_00705	1.797e-10	64.0	COG0454@1|root,COG0456@2|Bacteria,1VC3M@1239|Firmicutes,25AZ4@186801|Clostridia	186801|Clostridia	K	acetyltransferase, GNAT family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DEZH2_k127_2857740_1	269799.Gmet_0011	1.387e-29	125.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,43C40@68525|delta/epsilon subdivisions,2X7EG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	fgrK	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
DEZH2_k127_2862248_0	431943.CKL_1689	3.948e-124	406.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
DEZH2_k127_2862248_1	720554.Clocl_0919	4.763e-114	374.0	COG1304@1|root,COG1304@2|Bacteria,1TPC4@1239|Firmicutes,249TX@186801|Clostridia,3WKTR@541000|Ruminococcaceae	186801|Clostridia	C	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
DEZH2_k127_286756_4	1226325.HMPREF1548_01452	8.248e-34	134.0	COG0673@1|root,COG0673@2|Bacteria,1U4A4@1239|Firmicutes,249UF@186801|Clostridia,36FXW@31979|Clostridiaceae	186801|Clostridia	E	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_286756_1	1256908.HMPREF0373_03128	2.102e-76	275.0	COG2610@1|root,COG2610@2|Bacteria,1TQJ6@1239|Firmicutes,24839@186801|Clostridia	186801|Clostridia	EG	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	GntP_permease
DEZH2_k127_286756_5	1123075.AUDP01000036_gene1271	2.024e-26	124.0	COG2508@1|root,COG2508@2|Bacteria,1TRRH@1239|Firmicutes,24C6R@186801|Clostridia,3WNTJ@541000|Ruminococcaceae	186801|Clostridia	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
DEZH2_k127_286756_2	1043205.AFYF01000056_gene2656	1.553e-66	235.0	COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria,4FGCV@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
DEZH2_k127_286756_0	97138.C820_01512	1.027e-141	464.0	COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,24848@186801|Clostridia,36DHU@31979|Clostridiaceae	186801|Clostridia	F	pyrimidine-nucleoside phosphorylase	pdp	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08925	Glycos_trans_3N,Glycos_transf_3,PYNP_C
DEZH2_k127_286756_3	903814.ELI_2168	1.339e-46	171.0	COG3467@1|root,COG3467@2|Bacteria,1VB7Q@1239|Firmicutes,24MUQ@186801|Clostridia,25XMW@186806|Eubacteriaceae	186801|Clostridia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
DEZH2_k127_2869463_4	1215915.BN193_06595	9.422e-27	126.0	COG2815@1|root,COG2815@2|Bacteria,1V00M@1239|Firmicutes,4HD0Y@91061|Bacilli	91061|Bacilli	S	PASTA	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA
DEZH2_k127_2869463_0	509191.AEDB02000098_gene3513	9.915e-215	683.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247Q9@186801|Clostridia,3WGT9@541000|Ruminococcaceae	186801|Clostridia	S	ABC transporter	yfmR	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
DEZH2_k127_2869463_3	158190.SpiGrapes_0956	3.501e-46	171.0	COG2246@1|root,COG2246@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
DEZH2_k127_2869463_2	1511.CLOST_0106	6.213e-110	368.0	COG0025@1|root,COG0025@2|Bacteria,1UHUI@1239|Firmicutes,25E2Y@186801|Clostridia,25SQJ@186804|Peptostreptococcaceae	186801|Clostridia	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
DEZH2_k127_2869463_5	744872.Spica_2276	1.872e-11	71.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
DEZH2_k127_2869463_1	994573.T472_0206155	1.305e-149	488.0	COG4485@1|root,COG4485@2|Bacteria,1TRR1@1239|Firmicutes,24BHM@186801|Clostridia,36VYW@31979|Clostridiaceae	186801|Clostridia	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	GtrA,YfhO
DEZH2_k127_2882398_2	931626.Awo_c14850	2.335e-35	136.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia,25VEF@186806|Eubacteriaceae	186801|Clostridia	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
DEZH2_k127_2882398_0	903814.ELI_2538	8.91e-181	578.0	COG0437@1|root,COG4624@1|root,COG0437@2|Bacteria,COG4624@2|Bacteria,1TQIR@1239|Firmicutes,248BS@186801|Clostridia,25VE9@186806|Eubacteriaceae	186801|Clostridia	C	4Fe-4S binding domain protein	-	-	1.12.7.2	ko:K00533	-	-	R00019	-	ko00000,ko01000	-	-	-	Fe_hyd_lg_C,Fer4,Fer4_6
DEZH2_k127_2882398_3	1410668.JNKC01000004_gene238	5.175e-12	69.0	2EKY6@1|root,33EMQ@2|Bacteria,1VNMY@1239|Firmicutes,24UJM@186801|Clostridia,36SYD@31979|Clostridiaceae	186801|Clostridia	S	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
DEZH2_k127_2882398_1	693746.OBV_28750	1.005e-46	173.0	COG1595@1|root,COG1595@2|Bacteria,1V9ZH@1239|Firmicutes,24JR8@186801|Clostridia,2N7IW@216572|Oscillospiraceae	186801|Clostridia	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DEZH2_k127_2882752_1	1042156.CXIVA_14450	2.011e-66	234.0	COG1878@1|root,COG1878@2|Bacteria,1V07X@1239|Firmicutes,24EXW@186801|Clostridia,36GI4@31979|Clostridiaceae	186801|Clostridia	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
DEZH2_k127_2882752_0	1111135.HMPREF1248_0206	5.945e-284	893.0	COG0366@1|root,COG1640@1|root,COG0366@2|Bacteria,COG1640@2|Bacteria,2GJUT@201174|Actinobacteria,4CV47@84998|Coriobacteriia	84998|Coriobacteriia	G	Alpha amylase catalytic	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Alpha-amylase,Glyco_hydro_77
DEZH2_k127_2891668_2	575540.Isop_0444	2.346e-06	54.0	COG1506@1|root,COG1506@2|Bacteria,2J52Y@203682|Planctomycetes	203682|Planctomycetes	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2891668_1	1285586.H131_08088	5.352e-38	149.0	COG1266@1|root,COG1266@2|Bacteria,1VVP0@1239|Firmicutes,4HWDD@91061|Bacilli	91061|Bacilli	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
DEZH2_k127_2891668_0	489825.LYNGBM3L_30250	3.733e-92	308.0	COG0604@1|root,COG0604@2|Bacteria,1G0N4@1117|Cyanobacteria,1H9U9@1150|Oscillatoriales	1117|Cyanobacteria	C	NADPH quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
DEZH2_k127_2908458_3	697303.Thewi_2199	2.985e-11	66.0	COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,24GK6@186801|Clostridia,42GMH@68295|Thermoanaerobacterales	186801|Clostridia	S	HAD-superfamily hydrolase, subfamily IA	Gph	-	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
DEZH2_k127_2908458_2	370438.PTH_2445	5.649e-23	106.0	COG1961@1|root,COG1961@2|Bacteria,1TQAX@1239|Firmicutes,24B05@186801|Clostridia,262CM@186807|Peptococcaceae	186801|Clostridia	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Resolvase
DEZH2_k127_2908458_1	693746.OBV_15600	4.928e-61	230.0	COG0760@1|root,COG0760@2|Bacteria,1TSCQ@1239|Firmicutes,24CC5@186801|Clostridia,2N6T0@216572|Oscillospiraceae	186801|Clostridia	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03770,ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N_3
DEZH2_k127_2908458_0	203119.Cthe_2724	0.0	1678.0	COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,3WH6H@541000|Ruminococcaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
DEZH2_k127_2934886_0	357809.Cphy_1669	2.116e-129	418.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,21ZDG@1506553|Lachnoclostridium	186801|Clostridia	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
DEZH2_k127_2934886_1	357809.Cphy_1670	3.125e-128	413.0	COG1117@1|root,COG1117@2|Bacteria,1VR9J@1239|Firmicutes,24XMR@186801|Clostridia,222MS@1506553|Lachnoclostridium	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
DEZH2_k127_2934886_2	765910.MARPU_04570	2.345e-17	85.0	COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,1S69P@1236|Gammaproteobacteria,1WX67@135613|Chromatiales	135613|Chromatiales	K	cyclic nucleotide-binding	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
DEZH2_k127_3020392_3	509191.AEDB02000022_gene2959	0.0001136	55.0	COG0823@1|root,COG0823@2|Bacteria,1VUY2@1239|Firmicutes,24TVJ@186801|Clostridia	186801|Clostridia	U	Domain of unknown function (DUF5050)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5050
DEZH2_k127_3020392_2	208596.CAR_c19190	1.214e-23	113.0	2E9V0@1|root,3340V@2|Bacteria,1V6HR@1239|Firmicutes,4HIXZ@91061|Bacilli,27GRI@186828|Carnobacteriaceae	91061|Bacilli	M	carotenoid biosynthetic process	-	-	-	ko:K10212	ko00906,map00906	-	R07656	RC00041	ko00000,ko00001,ko01000	-	-	-	-
DEZH2_k127_3020392_1	1236976.JCM16418_1676	1e-63	233.0	COG1215@1|root,COG1215@2|Bacteria,1TRAD@1239|Firmicutes,4HAR8@91061|Bacilli,26S7X@186822|Paenibacillaceae	91061|Bacilli	M	glycosyl transferase family 2	crtQ	-	-	ko:K10211	ko00906,map00906	-	R07655	RC00523	ko00000,ko00001,ko01000	-	-	-	Glycos_transf_2
DEZH2_k127_3020392_0	158190.SpiGrapes_3087	2.018e-108	361.0	COG0493@1|root,COG1233@1|root,COG0493@2|Bacteria,COG1233@2|Bacteria,2J838@203691|Spirochaetes	203691|Spirochaetes	Q	Flavin containing amine oxidoreductase	-	-	1.3.99.23,5.2.1.13	ko:K09516,ko:K09835	ko00830,ko00906,ko01100,ko01110,map00830,map00906,map01100,map01110	M00097	R07163,R07512	RC01835,RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
DEZH2_k127_3031402_0	699246.HMPREF0868_0847	1.054e-205	646.0	COG0205@1|root,COG0205@2|Bacteria,1TRJQ@1239|Firmicutes,247IV@186801|Clostridia,2688K@186813|unclassified Clostridiales	186801|Clostridia	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
DEZH2_k127_3043925_0	588581.Cpap_2800	4.449e-149	475.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
DEZH2_k127_3043925_3	1392491.JIAE01000001_gene2524	1.318e-42	161.0	COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia,3WIDB@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
DEZH2_k127_3043925_2	903814.ELI_0149	9.982e-75	261.0	COG1235@1|root,COG1235@2|Bacteria,1TQ8E@1239|Firmicutes,249U2@186801|Clostridia,25VQ5@186806|Eubacteriaceae	186801|Clostridia	S	Metallo-beta-lactamase domain protein	yycJ	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
DEZH2_k127_3043925_1	699246.HMPREF0868_1280	5.523e-109	359.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,267K0@186813|unclassified Clostridiales	186801|Clostridia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
DEZH2_k127_305177_0	203119.Cthe_3200	8.074e-95	321.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
DEZH2_k127_305177_3	553184.ATORI0001_0367	5.32e-33	130.0	COG0537@1|root,COG0537@2|Bacteria	2|Bacteria	FG	bis(5'-adenosyl)-triphosphatase activity	hinT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019478,GO:0019752,GO:0043436,GO:0043530,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055130,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.1.1.226,2.1.1.227	ko:K02503,ko:K06442	-	-	-	-	ko00000,ko01000,ko03009,ko04147	-	-	-	DcpS_C,HIT
DEZH2_k127_305177_4	1392491.JIAE01000001_gene640	1.816e-24	104.0	COG0828@1|root,COG0828@2|Bacteria,1VEHU@1239|Firmicutes,24QP9@186801|Clostridia,3WKHJ@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
DEZH2_k127_305177_2	588581.Cpap_0682	6.767e-42	159.0	COG1610@1|root,COG1610@2|Bacteria,1V6F2@1239|Firmicutes,24JB0@186801|Clostridia,3WK1B@541000|Ruminococcaceae	186801|Clostridia	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
DEZH2_k127_305177_1	398512.JQKC01000008_gene970	5.819e-60	215.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,3WI09@541000|Ruminococcaceae	186801|Clostridia	L	exonuclease	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,ssDNA-exonuc_C
DEZH2_k127_3058492_3	1410638.JHXJ01000013_gene2336	8.487e-39	146.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,3WGP5@541000|Ruminococcaceae	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
DEZH2_k127_3058492_2	545694.TREPR_0314	1.233e-56	207.0	COG1968@1|root,COG1968@2|Bacteria,2J5SC@203691|Spirochaetes	203691|Spirochaetes	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
DEZH2_k127_3058492_1	1392491.JIAE01000001_gene1413	7.466e-68	244.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,249J1@186801|Clostridia,3WHEU@541000|Ruminococcaceae	186801|Clostridia	S	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Peptidase_S9
DEZH2_k127_3058492_0	500632.CLONEX_00160	4.914e-117	384.0	COG0463@1|root,COG0463@2|Bacteria,1UI8D@1239|Firmicutes,247P4@186801|Clostridia	186801|Clostridia	M	Glycosyltransferase, group 2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DEZH2_k127_3070977_1	411463.EUBVEN_01531	1.527e-70	244.0	COG1940@1|root,COG1940@2|Bacteria,1V1EQ@1239|Firmicutes,24FHR@186801|Clostridia	186801|Clostridia	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
DEZH2_k127_3070977_0	397288.C806_03395	3.482e-162	516.0	COG0673@1|root,COG0673@2|Bacteria,1TR8S@1239|Firmicutes,25AZV@186801|Clostridia	186801|Clostridia	S	oxidoreductase	-	-	1.1.1.371	ko:K16044	ko00562,ko01120,map00562,map01120	-	R09954	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_3070977_2	397287.C807_02997	7.985e-32	127.0	COG0673@1|root,COG0673@2|Bacteria,1TQSS@1239|Firmicutes,249QZ@186801|Clostridia,27ITG@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	ko:K22230	ko00562,ko01120,map00562,map01120	-	R09954	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA
DEZH2_k127_3079305_0	1298920.KI911353_gene4477	4.617e-221	700.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,21Y2R@1506553|Lachnoclostridium	186801|Clostridia	G	glycosyltransferase 36 associated	-	-	2.4.1.20,2.4.1.280	ko:K00702,ko:K18675	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00952,R09942	RC00049	ko00000,ko00001,ko01000	-	GH94,GT36	-	Glyco_hydro_36,Glyco_transf_36
DEZH2_k127_3094559_3	1123377.AUIV01000020_gene2446	1.389e-24	104.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,1RMB0@1236|Gammaproteobacteria,1X32Z@135614|Xanthomonadales	135614|Xanthomonadales	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
DEZH2_k127_3094559_2	1444306.JFZC01000038_gene2858	4.552e-37	147.0	COG1641@1|root,COG1641@2|Bacteria,1TPAV@1239|Firmicutes,4HC7I@91061|Bacilli	91061|Bacilli	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
DEZH2_k127_3094559_0	1410638.JHXJ01000030_gene275	2.531e-53	192.0	COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,24HCB@186801|Clostridia,3WITM@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
DEZH2_k127_3094559_1	665956.HMPREF1032_02810	4.314e-45	167.0	COG0299@1|root,COG3363@1|root,COG0299@2|Bacteria,COG3363@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,3WIAG@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04225	Formyl_trans_N
DEZH2_k127_3099514_5	1519439.JPJG01000064_gene1785	1.133e-10	63.0	COG0834@1|root,COG0834@2|Bacteria,1TQNR@1239|Firmicutes,249Y5@186801|Clostridia,2N76T@216572|Oscillospiraceae	186801|Clostridia	ET	Bacterial periplasmic substrate-binding proteins	fliY1	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
DEZH2_k127_3099514_4	622312.ROSEINA2194_00469	4.722e-81	276.0	COG0765@1|root,COG0765@2|Bacteria,1V280@1239|Firmicutes,25C2S@186801|Clostridia	186801|Clostridia	P	Abc transporter, permease protein	tcyB	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
DEZH2_k127_3099514_3	500632.CLONEX_03077	1.656e-103	342.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia	186801|Clostridia	E	abc transporter atp-binding protein	glnQ	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
DEZH2_k127_3099514_2	180332.JTGN01000010_gene4451	6.033e-112	368.0	COG1082@1|root,COG1082@2|Bacteria,1UYHR@1239|Firmicutes,25C7S@186801|Clostridia	186801|Clostridia	G	Psort location Cytoplasmic, score 8.87	-	GO:0003674,GO:0003824,GO:0005488,GO:0016853,GO:0016854,GO:0016857,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050897	5.1.3.30,5.1.3.31	ko:K18910	-	-	R10817,R10818	RC03111,RC03283	ko00000,ko01000	-	-	-	AP_endonuc_2
DEZH2_k127_3099514_0	588581.Cpap_3547	2.345e-176	562.0	COG4573@1|root,COG4573@2|Bacteria,1TQDN@1239|Firmicutes,24A03@186801|Clostridia,3WP0J@541000|Ruminococcaceae	186801|Clostridia	G	Tagatose 6 phosphate kinase	-	-	-	ko:K16371	ko00052,ko01100,map00052,map01100	-	R01069	RC00438,RC00439	ko00000,ko00001	-	-	-	Tagatose_6_P_K
DEZH2_k127_3099514_1	1122947.FR7_1360	1.83e-140	449.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes	1239|Firmicutes	E	Dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
DEZH2_k127_3103188_1	29495.EA26_04605	1.097e-73	252.0	COG1187@1|root,COG1187@2|Bacteria,1MXQE@1224|Proteobacteria,1RMC7@1236|Gammaproteobacteria,1XTHG@135623|Vibrionales	135623|Vibrionales	J	Belongs to the pseudouridine synthase RsuA family	rluF	-	5.4.99.21	ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
DEZH2_k127_3103188_2	138119.DSY3621	1.649e-18	90.0	COG0642@1|root,COG2205@2|Bacteria	138119.DSY3621|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3103188_0	1392491.JIAE01000001_gene1545	2.003e-80	275.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3WGR7@541000|Ruminococcaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07651	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS
DEZH2_k127_3114300_2	926692.AZYG01000038_gene1056	7.925e-26	108.0	COG0364@1|root,COG0364@2|Bacteria,1TPYF@1239|Firmicutes,24939@186801|Clostridia,3WA9J@53433|Halanaerobiales	186801|Clostridia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
DEZH2_k127_3114300_0	580327.Tthe_1639	4.182e-72	248.0	COG1878@1|root,COG1878@2|Bacteria,1UFUJ@1239|Firmicutes,24HGD@186801|Clostridia,42F34@68295|Thermoanaerobacterales	186801|Clostridia	S	cyclase family	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
DEZH2_k127_3114300_1	411489.CLOL250_00519	3.924e-64	225.0	COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,247U8@186801|Clostridia,36DF7@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
DEZH2_k127_312070_1	1122947.FR7_3691	7.01e-103	338.0	COG1319@1|root,COG1319@2|Bacteria,1UZF3@1239|Firmicutes,4H909@909932|Negativicutes	909932|Negativicutes	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
DEZH2_k127_312070_0	370438.PTH_2319	3.527e-155	500.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,2643H@186807|Peptococcaceae	186801|Clostridia	F	Cytosine deaminase-like metal-dependent hydrolase	guaD	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
DEZH2_k127_312070_2	1304284.L21TH_0351	1.632e-52	192.0	COG0477@1|root,COG2814@2|Bacteria,1TQDU@1239|Firmicutes,25ESY@186801|Clostridia,36V3T@31979|Clostridiaceae	186801|Clostridia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,PUCC,Sugar_tr
DEZH2_k127_3122437_5	1121335.Clst_1303	2.204e-42	162.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia,3WGPQ@541000|Ruminococcaceae	186801|Clostridia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
DEZH2_k127_3122437_3	203119.Cthe_0570	3.108e-68	239.0	COG2738@1|root,COG2738@2|Bacteria,1TPD3@1239|Firmicutes,2490Y@186801|Clostridia,3WICN@541000|Ruminococcaceae	186801|Clostridia	S	zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
DEZH2_k127_3122437_2	1121468.AUBR01000005_gene33	1.61e-91	317.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,42EKD@68295|Thermoanaerobacterales	186801|Clostridia	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
DEZH2_k127_3122437_0	398512.JQKC01000008_gene991	5.859e-121	399.0	COG0820@1|root,COG0820@2|Bacteria,1TPVF@1239|Firmicutes,248BC@186801|Clostridia,3WGYF@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
DEZH2_k127_3122437_4	699246.HMPREF0868_1150	1.364e-58	212.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,26800@186813|unclassified Clostridiales	186801|Clostridia	T	Serine/threonine phosphatases, family 2C, catalytic domain	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
DEZH2_k127_3122437_1	1392491.JIAE01000001_gene1055	6.594e-117	383.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3WGK8@541000|Ruminococcaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
DEZH2_k127_3124957_3	457421.CBFG_02676	4.181e-21	98.0	COG1345@1|root,COG1345@2|Bacteria,1TQ66@1239|Firmicutes,248Q9@186801|Clostridia,269BU@186813|unclassified Clostridiales	186801|Clostridia	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	-	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
DEZH2_k127_3124957_2	697281.Mahau_2728	2.688e-27	115.0	COG1516@1|root,COG1516@2|Bacteria,1VA8K@1239|Firmicutes,24MRW@186801|Clostridia,42GV2@68295|Thermoanaerobacterales	186801|Clostridia	N	PFAM flagellar protein FliS	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
DEZH2_k127_3124957_0	1292035.H476_0857	7.322e-48	173.0	COG2201@1|root,COG2201@2|Bacteria,1VBRC@1239|Firmicutes,24J81@186801|Clostridia,25TDB@186804|Peptostreptococcaceae	186801|Clostridia	NT	cheY-homologous receiver domain	cheY2	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
DEZH2_k127_3124957_1	203119.Cthe_0810	1.67e-38	149.0	COG0643@1|root,COG0643@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,3WH05@541000|Ruminococcaceae	186801|Clostridia	NT	Signal transducing histidine kinase homodimeric	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
DEZH2_k127_3133083_1	556261.HMPREF0240_00633	5.127e-102	341.0	COG0716@1|root,COG0716@2|Bacteria,1VF5I@1239|Firmicutes	1239|Firmicutes	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
DEZH2_k127_3133083_0	696369.KI912183_gene364	1.615e-120	416.0	COG3290@1|root,COG3437@1|root,COG3290@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24Y6H@186801|Clostridia,267AY@186807|Peptococcaceae	186801|Clostridia	T	diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HAMP,HD,HD_5,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3,dCache_1
DEZH2_k127_3133083_2	1123075.AUDP01000037_gene141	1.093e-37	153.0	COG0583@1|root,COG0583@2|Bacteria,1VI7P@1239|Firmicutes,24MQD@186801|Clostridia	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
DEZH2_k127_3133083_3	573413.Spirs_3380	1.675e-09	63.0	COG0407@1|root,COG0407@2|Bacteria,2JAKX@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DEZH2_k127_3187144_1	160799.PBOR_26030	2.891e-53	200.0	COG2207@1|root,COG2207@2|Bacteria,1V5I2@1239|Firmicutes,4HMB9@91061|Bacilli,26QSW@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_18
DEZH2_k127_3187144_0	1122927.KB895414_gene5445	1.09e-57	207.0	COG1082@1|root,COG1082@2|Bacteria,1UZ90@1239|Firmicutes,4HHIS@91061|Bacilli,26XYV@186822|Paenibacillaceae	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_3195628_1	1123228.AUIH01000011_gene2141	7.53e-22	103.0	COG1011@1|root,COG1011@2|Bacteria,1QSY2@1224|Proteobacteria,1RWK3@1236|Gammaproteobacteria,1XM90@135619|Oceanospirillales	135619|Oceanospirillales	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	3.1.3.10	ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
DEZH2_k127_3195628_0	699246.HMPREF0868_0093	1.128e-84	288.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,267W5@186813|unclassified Clostridiales	186801|Clostridia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
DEZH2_k127_3232792_5	1449050.JNLE01000003_gene1627	3.427e-46	171.0	COG4989@1|root,COG4989@2|Bacteria,1TQ12@1239|Firmicutes,248NF@186801|Clostridia,36F2U@31979|Clostridiaceae	186801|Clostridia	S	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
DEZH2_k127_3232792_6	1034769.KB910518_gene2951	2.25e-35	139.0	COG5646@1|root,COG5646@2|Bacteria,1V6QB@1239|Firmicutes,4HINV@91061|Bacilli,26YRN@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
DEZH2_k127_3232792_3	768704.Desmer_1317	5.595e-51	190.0	COG3279@1|root,COG3279@2|Bacteria,1TSDB@1239|Firmicutes,24MQ4@186801|Clostridia,262WU@186807|Peptococcaceae	186801|Clostridia	K	Response regulator of the LytR AlgR family	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
DEZH2_k127_3232792_7	397287.C807_00240	3.321e-08	63.0	COG3290@1|root,COG3290@2|Bacteria,1UVCX@1239|Firmicutes,2553Z@186801|Clostridia,27P5T@186928|unclassified Lachnospiraceae	186801|Clostridia	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_5
DEZH2_k127_3232792_4	768710.DesyoDRAFT_1319	1.917e-49	183.0	COG3290@1|root,COG3290@2|Bacteria,1V34R@1239|Firmicutes,25AZ0@186801|Clostridia	186801|Clostridia	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_5
DEZH2_k127_3232792_2	411463.EUBVEN_02306	2.994e-83	287.0	COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,248DH@186801|Clostridia,25UQH@186806|Eubacteriaceae	186801|Clostridia	C	Belongs to the LDH MDH superfamily. LDH family	ldh	-	1.1.1.27	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	-	R00703,R01000,R03104	RC00031,RC00044	ko00000,ko00001,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
DEZH2_k127_3232792_0	1078085.HMPREF1210_00099	9.122e-262	829.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,4HAAG@91061|Bacilli	91061|Bacilli	G	Belongs to the glycosyl hydrolase 3 family	bglB	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
DEZH2_k127_3232792_1	580327.Tthe_1962	4.558e-156	503.0	COG2223@1|root,COG2223@2|Bacteria,1UM9S@1239|Firmicutes,25GD1@186801|Clostridia,42J88@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DEZH2_k127_3232792_8	1220534.B655_2414	9.963e-07	51.0	COG0716@1|root,arCOG00519@2157|Archaea,2Y43Z@28890|Euryarchaeota	28890|Euryarchaeota	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
DEZH2_k127_3234839_1	699246.HMPREF0868_1451	8.874e-33	138.0	COG0860@1|root,COG0860@2|Bacteria	2|Bacteria	M	N-Acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448,ko:K02172	ko01501,ko01503,map01501,map01503	M00627,M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko03036	-	-	-	Amidase_3,Cu_amine_oxidN1,Glucosaminidase,PG_binding_1,Peptidase_M56,Y_Y_Y
DEZH2_k127_3234839_0	319795.Dgeo_2783	2.313e-78	271.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
DEZH2_k127_3237460_4	335543.Sfum_1210	1.51e-08	61.0	COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,42MHJ@68525|delta/epsilon subdivisions,2WM6S@28221|Deltaproteobacteria,2MS5F@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	NIF3 (NGG1p interacting factor 3)	-	-	3.5.4.16	ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	NIF3
DEZH2_k127_3237460_1	1410638.JHXJ01000002_gene1410	1.38e-158	511.0	COG0150@1|root,COG0150@2|Bacteria	2|Bacteria	F	phosphoribosylformylglycinamidine cyclo-ligase activity	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C
DEZH2_k127_3237460_2	699246.HMPREF0868_0874	2.581e-38	146.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
DEZH2_k127_3237460_0	699246.HMPREF0868_0875	1.552e-301	936.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,2681N@186813|unclassified Clostridiales	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
DEZH2_k127_3285342_6	502558.EGYY_13370	7.989e-07	58.0	COG4509@1|root,COG4509@2|Bacteria	2|Bacteria	S	Sortase family	-	-	3.4.22.70	ko:K08600	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	CarboxypepD_reg,Flg_new,Sortase,fn3
DEZH2_k127_3285342_5	941824.TCEL_01963	4.655e-60	217.0	COG0561@1|root,COG0561@2|Bacteria,1TR16@1239|Firmicutes,248MW@186801|Clostridia,36F52@31979|Clostridiaceae	186801|Clostridia	S	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
DEZH2_k127_3285342_4	699246.HMPREF0868_1248	6.034e-72	246.0	COG0048@1|root,COG0048@2|Bacteria,1V1FJ@1239|Firmicutes,24FQT@186801|Clostridia,268YZ@186813|unclassified Clostridiales	186801|Clostridia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
DEZH2_k127_3285342_3	699246.HMPREF0868_1247	7.55e-83	277.0	COG0049@1|root,COG0049@2|Bacteria,1V1GG@1239|Firmicutes,24FQN@186801|Clostridia,268CC@186813|unclassified Clostridiales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
DEZH2_k127_3285342_0	699246.HMPREF0868_1246	0.0	1124.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,267V9@186813|unclassified Clostridiales	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DEZH2_k127_3285342_1	699246.HMPREF0868_1245	5.29e-219	684.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,267PG@186813|unclassified Clostridiales	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
DEZH2_k127_3285342_2	203119.Cthe_0082	1.028e-127	422.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,3WH4M@541000|Ruminococcaceae	186801|Clostridia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
DEZH2_k127_3319103_1	1042156.CXIVA_15500	2.181e-07	55.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,36EIX@31979|Clostridiaceae	186801|Clostridia	G	Aldolase	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
DEZH2_k127_3319103_0	1034769.KB910518_gene2775	0.0	1042.0	COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,4HDFB@91061|Bacilli,26RVF@186822|Paenibacillaceae	91061|Bacilli	G	Alpha-L-rhamnosidase	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
DEZH2_k127_3321907_3	720554.Clocl_2519	1.589e-24	105.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,3WGNU@541000|Ruminococcaceae	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
DEZH2_k127_3321907_0	1410624.JNKK01000004_gene302	3.945e-113	382.0	COG1625@1|root,COG1625@2|Bacteria,1TSFU@1239|Firmicutes,247JK@186801|Clostridia,27IIF@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Protein of unknown function (DUF512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
DEZH2_k127_3321907_4	720554.Clocl_2521	1.453e-21	95.0	COG0333@1|root,COG0333@2|Bacteria,1VEFI@1239|Firmicutes,24QM0@186801|Clostridia,3WKRF@541000|Ruminococcaceae	186801|Clostridia	J	Ribosomal L32p protein family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
DEZH2_k127_3321907_2	699246.HMPREF0868_0452	4.594e-34	136.0	COG1399@1|root,COG1399@2|Bacteria,1VEXU@1239|Firmicutes,24RKT@186801|Clostridia	186801|Clostridia	S	acr, cog1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
DEZH2_k127_3321907_1	1195236.CTER_0329	5.698e-101	341.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,1TQ02@1239|Firmicutes,249HC@186801|Clostridia,3WNAJ@541000|Ruminococcaceae	186801|Clostridia	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
DEZH2_k127_3326957_0	203119.Cthe_0896	3.724e-121	398.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,3WGFW@541000|Ruminococcaceae	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
DEZH2_k127_3326957_1	203119.Cthe_0905	2.711e-71	248.0	COG3294@1|root,COG3294@2|Bacteria,1UXSS@1239|Firmicutes,24A8Y@186801|Clostridia,3WGCK@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
DEZH2_k127_3326957_3	1268072.PSAB_13600	1.025e-34	144.0	COG0663@1|root,COG0663@2|Bacteria,1V6CZ@1239|Firmicutes,4HFPC@91061|Bacilli,26X34@186822|Paenibacillaceae	91061|Bacilli	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	caiE	-	-	-	-	-	-	-	-	-	-	-	Hexapep
DEZH2_k127_3326957_2	699246.HMPREF0868_0866	1.263e-57	203.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,267WA@186813|unclassified Clostridiales	186801|Clostridia	C	4Fe-4S single cluster domain	scfB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
DEZH2_k127_3343026_4	1121335.Clst_0497	7.086e-10	61.0	COG2367@1|root,COG2367@2|Bacteria,1V5VP@1239|Firmicutes,25B0P@186801|Clostridia,3WS8C@541000|Ruminococcaceae	186801|Clostridia	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2,LysM,PG_binding_1
DEZH2_k127_3343026_1	699246.HMPREF0868_0982	5.604e-74	259.0	COG1284@1|root,COG1284@2|Bacteria,1TR9J@1239|Firmicutes,24BGW@186801|Clostridia,268IY@186813|unclassified Clostridiales	186801|Clostridia	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
DEZH2_k127_3343026_2	690585.JNNU01000037_gene1083	1.473e-15	85.0	COG0346@1|root,COG0346@2|Bacteria,1PJ3N@1224|Proteobacteria,2UF0Z@28211|Alphaproteobacteria,4BF72@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
DEZH2_k127_3343026_0	203119.Cthe_2144	8.111e-105	347.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,3WGA1@541000|Ruminococcaceae	186801|Clostridia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
DEZH2_k127_3343026_3	1291050.JAGE01000001_gene1910	7.622e-11	71.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,3WGA1@541000|Ruminococcaceae	186801|Clostridia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
DEZH2_k127_3353075_2	1195236.CTER_5037	2.009e-16	84.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,3WJKQ@541000|Ruminococcaceae	186801|Clostridia	S	basic membrane	tmpC	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
DEZH2_k127_3353075_0	748224.HMPREF9436_00937	2.169e-254	793.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,3WSIS@541000|Ruminococcaceae	186801|Clostridia	S	transport systems ATPase components	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
DEZH2_k127_3353075_1	411471.SUBVAR_05521	1.382e-40	153.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,3WHM5@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
DEZH2_k127_3362739_1	1408322.JHYK01000009_gene2235	2.031e-94	315.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,27K0S@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
DEZH2_k127_3362739_0	1408322.JHYK01000009_gene2234	1.236e-138	449.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,27JMJ@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
DEZH2_k127_3362739_2	1410628.JNKS01000005_gene1154	4.412e-80	271.0	COG1435@1|root,COG1435@2|Bacteria,1TRVM@1239|Firmicutes,24CVH@186801|Clostridia,27KRC@186928|unclassified Lachnospiraceae	186801|Clostridia	F	Thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
DEZH2_k127_3362739_3	748727.CLJU_c33520	1.77e-18	89.0	COG0463@1|root,COG0463@2|Bacteria,1TT6C@1239|Firmicutes,248F2@186801|Clostridia,36DBP@31979|Clostridiaceae	186801|Clostridia	M	Glycosyl transferase family 2	kfoC_2	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DEZH2_k127_3372537_0	1163617.SCD_n01025	1.824e-49	184.0	COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Belongs to the ompA family	rmpM	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA,SmpA_OmlA
DEZH2_k127_3372537_1	697282.Mettu_0612	2.577e-33	132.0	COG2823@1|root,COG2823@2|Bacteria,1N0SU@1224|Proteobacteria,1S926@1236|Gammaproteobacteria,1XFQA@135618|Methylococcales	135618|Methylococcales	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
DEZH2_k127_3372537_2	159087.Daro_2052	2.376e-16	81.0	COG2823@1|root,COG2823@2|Bacteria,1NIM8@1224|Proteobacteria,2VX5E@28216|Betaproteobacteria	28216|Betaproteobacteria	S	SMART Transport-associated and nodulation	-	-	-	-	-	-	-	-	-	-	-	-	BON
DEZH2_k127_3387297_2	742738.HMPREF9460_03160	1.049e-41	157.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2499D@186801|Clostridia,26AMM@186813|unclassified Clostridiales	186801|Clostridia	I	Thiolase, C-terminal domain	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
DEZH2_k127_3387297_1	768706.Desor_1756	6.413e-84	287.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia,261F6@186807|Peptococcaceae	186801|Clostridia	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
DEZH2_k127_3387297_0	457421.CBFG_04637	1.697e-312	962.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,267KG@186813|unclassified Clostridiales	186801|Clostridia	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	1.14.14.9	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	-	R02698,R03299	RC00046	ko00000,ko00001,ko01000	-	-	-	HpaB,HpaB_N
DEZH2_k127_3389629_0	203119.Cthe_1221	3.575e-224	708.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,3WGK9@541000|Ruminococcaceae	186801|Clostridia	G	Glycosyltransferase family 36	ndvB	-	-	-	-	-	-	-	-	-	-	-	DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase
DEZH2_k127_339310_2	646529.Desaci_2496	6.808e-60	210.0	COG3369@1|root,COG3369@2|Bacteria,1TV60@1239|Firmicutes,24D1A@186801|Clostridia,264MH@186807|Peptococcaceae	186801|Clostridia	S	CDGSH-type zinc finger. Function unknown.	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_19,zf-CDGSH
DEZH2_k127_339310_4	1235800.C819_00616	5.207e-10	63.0	COG0454@1|root,COG0456@2|Bacteria,1V615@1239|Firmicutes,24RHN@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
DEZH2_k127_339310_5	1231377.C426_1206	0.0004167	46.0	COG0454@1|root,COG0456@2|Bacteria,1V615@1239|Firmicutes,4HIB2@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
DEZH2_k127_339310_1	742738.HMPREF9460_02333	4.801e-145	469.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia,267ST@186813|unclassified Clostridiales	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	pdxB	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
DEZH2_k127_339310_0	428125.CLOLEP_03881	1.232e-162	518.0	COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,247SM@186801|Clostridia,3WGD1@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
DEZH2_k127_339310_3	204669.Acid345_2517	7.038e-51	189.0	COG3809@1|root,COG3809@2|Bacteria,3Y803@57723|Acidobacteria	57723|Acidobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	DZR,zf-TFIIB
DEZH2_k127_3402931_0	755731.Clo1100_4087	8.212e-203	637.0	COG1070@1|root,COG1070@2|Bacteria,1TP91@1239|Firmicutes,24A4Z@186801|Clostridia,36G1B@31979|Clostridiaceae	186801|Clostridia	G	Carbohydrate kinase, FGGY	araB	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
DEZH2_k127_3402931_1	1449050.JNLE01000003_gene367	4.047e-187	596.0	COG2160@1|root,COG2160@2|Bacteria,1TPXC@1239|Firmicutes,24A08@186801|Clostridia,36EAS@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the conversion of L-arabinose to L-ribulose	araA	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Iso_C,Arabinose_Isome
DEZH2_k127_3433251_1	394503.Ccel_2098	2.234e-52	189.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,36E48@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
DEZH2_k127_3433251_2	203119.Cthe_3044	8.458e-34	143.0	COG5523@1|root,COG5523@2|Bacteria,1V6FC@1239|Firmicutes,24JPX@186801|Clostridia,3WJR0@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF975
DEZH2_k127_3433251_3	1499683.CCFF01000017_gene1956	1.041e-33	140.0	COG5523@1|root,COG5523@2|Bacteria,1V6FC@1239|Firmicutes,24JPX@186801|Clostridia,36WXQ@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF975)	-	-	-	-	-	-	-	-	-	-	-	-	DUF975
DEZH2_k127_3433251_0	994573.T472_0201080	4.177e-186	590.0	COG4260@1|root,COG4260@2|Bacteria,1TRYU@1239|Firmicutes,24901@186801|Clostridia,36GFC@31979|Clostridiaceae	186801|Clostridia	L	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1
DEZH2_k127_3433251_4	994573.T472_0201075	9.597e-27	110.0	COG1645@1|root,COG1645@2|Bacteria,1TRYG@1239|Firmicutes,25F3V@186801|Clostridia,36UYV@31979|Clostridiaceae	186801|Clostridia	S	bacterial-type flagellum-dependent swarming motility	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3454630_4	699246.HMPREF0868_0046	2.133e-29	119.0	COG4472@1|root,COG4472@2|Bacteria,1VAC4@1239|Firmicutes,24QVQ@186801|Clostridia	186801|Clostridia	S	Belongs to the UPF0297 family	yrzL	-	-	-	-	-	-	-	-	-	-	-	DUF965
DEZH2_k127_3454630_0	498761.HM1_0532	1.231e-93	317.0	COG0667@1|root,COG1145@1|root,COG0667@2|Bacteria,COG1145@2|Bacteria,1UHXA@1239|Firmicutes,25E68@186801|Clostridia	186801|Clostridia	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,Fer4
DEZH2_k127_3454630_2	1410638.JHXJ01000003_gene1478	2.276e-44	165.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,3WJ8E@541000|Ruminococcaceae	186801|Clostridia	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
DEZH2_k127_3454630_5	1392491.JIAE01000001_gene1944	1.117e-18	90.0	2911U@1|root,2ZNPD@2|Bacteria,1W5JX@1239|Firmicutes,256U0@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF1292)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1292
DEZH2_k127_3454630_1	699246.HMPREF0868_0042	4.922e-65	233.0	COG4866@1|root,COG4866@2|Bacteria,1TR2J@1239|Firmicutes,2480E@186801|Clostridia	186801|Clostridia	J	Psort location Cytoplasmic, score	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
DEZH2_k127_3454630_6	857293.CAAU_2540	5.392e-18	94.0	COG1266@1|root,COG1266@2|Bacteria,1VF60@1239|Firmicutes,24QSC@186801|Clostridia	186801|Clostridia	S	CAAX amino terminal protease family protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
DEZH2_k127_3482974_1	1514668.JOOA01000002_gene2074	3.689e-21	100.0	COG1470@1|root,COG1470@2|Bacteria,1TRGE@1239|Firmicutes,24EHG@186801|Clostridia,3WJFN@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
DEZH2_k127_3482974_0	1347369.CCAD010000074_gene3493	9.746e-22	104.0	COG1285@1|root,COG1285@2|Bacteria,1TRUW@1239|Firmicutes,4HCNB@91061|Bacilli,1ZBK9@1386|Bacillus	91061|Bacilli	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
DEZH2_k127_3482974_4	658088.HMPREF0987_02525	3.198e-07	59.0	2DPVJ@1|root,333JK@2|Bacteria,1VGI4@1239|Firmicutes,24R70@186801|Clostridia,27PIS@186928|unclassified Lachnospiraceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DZR,zinc_ribbon_2
DEZH2_k127_3482974_2	318464.IO99_18535	1.357e-18	87.0	2E5HW@1|root,33098@2|Bacteria,1VFFD@1239|Firmicutes,24QMD@186801|Clostridia,36NNW@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3482974_3	580331.Thit_1413	1.953e-09	63.0	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,24QK6@186801|Clostridia,42GMV@68295|Thermoanaerobacterales	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
DEZH2_k127_3488865_1	357809.Cphy_1668	9.37e-62	215.0	COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia,21XIB@1506553|Lachnoclostridium	186801|Clostridia	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
DEZH2_k127_3488865_0	1298920.KI911353_gene1395	6.316e-115	376.0	COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia,2219W@1506553|Lachnoclostridium	186801|Clostridia	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
DEZH2_k127_3488865_2	552811.Dehly_1323	2e-58	206.0	COG0704@1|root,COG0704@2|Bacteria,2G6HD@200795|Chloroflexi,34D3P@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
DEZH2_k127_3492908_3	1410668.JNKC01000001_gene1749	1.348e-45	171.0	COG4894@1|root,COG4894@2|Bacteria,1V3WA@1239|Firmicutes,24MB0@186801|Clostridia,36KCK@31979|Clostridiaceae	186801|Clostridia	S	LURP-one-related	-	-	-	-	-	-	-	-	-	-	-	-	LOR
DEZH2_k127_3492908_5	1449126.JQKL01000084_gene1174	5.758e-13	77.0	COG0653@1|root,COG3012@1|root,COG0653@2|Bacteria,COG3012@2|Bacteria,1VC2R@1239|Firmicutes,24SRY@186801|Clostridia	186801|Clostridia	U	SEC-C motif	-	-	-	-	-	-	-	-	-	-	-	-	SEC-C
DEZH2_k127_3492908_0	1121335.Clst_0964	4.544e-112	367.0	COG2013@1|root,COG2013@2|Bacteria,1TPN2@1239|Firmicutes,2499B@186801|Clostridia,3WHAW@541000|Ruminococcaceae	186801|Clostridia	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
DEZH2_k127_3492908_1	1291050.JAGE01000001_gene2404	4.241e-73	259.0	COG1575@1|root,COG1575@2|Bacteria,1TSZV@1239|Firmicutes,24A9J@186801|Clostridia	186801|Clostridia	H	PFAM UbiA prenyltransferase	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
DEZH2_k127_3492908_2	1469948.JPNB01000003_gene152	4.462e-61	223.0	COG0142@1|root,COG0142@2|Bacteria,1TR0U@1239|Firmicutes,24AW3@186801|Clostridia,36DFW@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
DEZH2_k127_3492908_4	1120746.CCNL01000014_gene2153	3.093e-43	160.0	COG1252@1|root,COG1252@2|Bacteria,2NP3T@2323|unclassified Bacteria	2|Bacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	DoxD,DoxX,Pyr_redox_2
DEZH2_k127_35040_1	1122211.JMLW01000017_gene1552	1.161e-51	197.0	COG2244@1|root,COG2244@2|Bacteria,1RC2S@1224|Proteobacteria,1S5QR@1236|Gammaproteobacteria,1XNBJ@135619|Oceanospirillales	135619|Oceanospirillales	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3
DEZH2_k127_35040_0	360104.CCC13826_0524	4.293e-108	359.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2YM9T@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
DEZH2_k127_3509952_6	1122915.AUGY01000025_gene6851	3.607e-13	70.0	COG1125@1|root,COG1125@2|Bacteria,1TPV8@1239|Firmicutes,4H9SI@91061|Bacilli,26SM2@186822|Paenibacillaceae	91061|Bacilli	E	Glycine betaine	proV	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
DEZH2_k127_3509952_1	1227352.C173_17276	1.397e-128	416.0	COG1732@1|root,COG1732@2|Bacteria,1TQ7D@1239|Firmicutes,4HBDR@91061|Bacilli,26V68@186822|Paenibacillaceae	91061|Bacilli	M	Glycine betaine ABC transporter substrate-binding protein	proWX	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
DEZH2_k127_3509952_3	665942.HMPREF1022_02341	1.901e-72	250.0	COG1174@1|root,COG1174@2|Bacteria,1MXA1@1224|Proteobacteria,42UI3@68525|delta/epsilon subdivisions,2WQ1V@28221|Deltaproteobacteria,2MHB8@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
DEZH2_k127_3509952_4	562743.JH976434_gene1834	3.656e-53	192.0	2EGE1@1|root,33A5Y@2|Bacteria,1VV4C@1239|Firmicutes,4HVGE@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3509952_5	158190.SpiGrapes_2376	3.145e-30	121.0	COG1476@1|root,COG1476@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
DEZH2_k127_3509952_2	158190.SpiGrapes_2377	6.505e-102	343.0	COG0604@1|root,COG0604@2|Bacteria,2J6WP@203691|Spirochaetes	203691|Spirochaetes	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
DEZH2_k127_3509952_0	903814.ELI_4480	1.706e-178	568.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,249CQ@186801|Clostridia,25YC1@186806|Eubacteriaceae	186801|Clostridia	P	E1-E2 ATPase	copB	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
DEZH2_k127_3516415_0	1410638.JHXJ01000042_gene2487	5.373e-170	552.0	COG1022@1|root,COG1022@2|Bacteria,1TS22@1239|Firmicutes,24AZW@186801|Clostridia,3WHKE@541000|Ruminococcaceae	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
DEZH2_k127_3522562_0	1410638.JHXJ01000013_gene2319	9.586e-215	673.0	COG2848@1|root,COG2848@2|Bacteria,1TQG8@1239|Firmicutes,247K4@186801|Clostridia,3WGZM@541000|Ruminococcaceae	186801|Clostridia	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
DEZH2_k127_3522562_1	272562.CA_C0415	3.328e-10	72.0	COG0457@1|root,COG0457@2|Bacteria,1UYZH@1239|Firmicutes,24BU9@186801|Clostridia,36NTK@31979|Clostridiaceae	186801|Clostridia	S	Anaphase-promoting complex, cyclosome, subunit 3	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
DEZH2_k127_3529961_3	1408473.JHXO01000011_gene3178	3.835e-55	194.0	COG0524@1|root,COG0524@2|Bacteria,4NH8K@976|Bacteroidetes,2FM8P@200643|Bacteroidia	976|Bacteroidetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
DEZH2_k127_3529961_0	138119.DSY1210	5.301e-239	754.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,261F5@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system, ATPase and permease component	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DEZH2_k127_3529961_4	1120998.AUFC01000006_gene877	2.734e-25	110.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR
DEZH2_k127_3529961_2	720554.Clocl_0391	2.38e-87	301.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,3WGDN@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
DEZH2_k127_3529961_1	1392491.JIAE01000001_gene383	6.28e-153	495.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia,3WGA7@541000|Ruminococcaceae	186801|Clostridia	J	translation elongation	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DEZH2_k127_3537075_3	748727.CLJU_c20660	8.324e-31	126.0	COG5423@1|root,COG5423@2|Bacteria,1V5K8@1239|Firmicutes,25DJ3@186801|Clostridia,36UC1@31979|Clostridiaceae	186801|Clostridia	S	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
DEZH2_k127_3537075_1	1226325.HMPREF1548_02728	2.789e-76	267.0	COG1609@1|root,COG1609@2|Bacteria,1UXXV@1239|Firmicutes,24A5P@186801|Clostridia,36WA8@31979|Clostridiaceae	186801|Clostridia	K	Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
DEZH2_k127_3537075_0	1195236.CTER_4234	1.525e-89	302.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,3WHTT@541000|Ruminococcaceae	186801|Clostridia	G	Dehydrogenase E1 component	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
DEZH2_k127_3537075_2	632518.Calow_0321	5.153e-62	218.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,42HY9@68295|Thermoanaerobacterales	186801|Clostridia	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
DEZH2_k127_3537385_0	720554.Clocl_0779	5.427e-60	220.0	COG0407@1|root,COG0407@2|Bacteria,1UYXW@1239|Firmicutes,25DH8@186801|Clostridia,3WI68@541000|Ruminococcaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DEZH2_k127_3617337_2	1121335.Clst_0179	1.564e-11	65.0	COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,3WGFC@541000|Ruminococcaceae	186801|Clostridia	KL	SNF2 family	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
DEZH2_k127_3617337_1	1499967.BAYZ01000032_gene1133	2.036e-14	74.0	COG0205@1|root,COG0205@2|Bacteria,2NP3J@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
DEZH2_k127_3667601_3	1195236.CTER_0151	3.078e-11	64.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,3WHR4@541000|Ruminococcaceae	186801|Clostridia	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
DEZH2_k127_3667601_0	699246.HMPREF0868_1294	2.817e-69	247.0	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,267IV@186813|unclassified Clostridiales	186801|Clostridia	U	60Kd inner membrane protein	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
DEZH2_k127_3667601_1	1410638.JHXJ01000008_gene416	4.619e-27	111.0	COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,24QN4@186801|Clostridia,3WKGN@541000|Ruminococcaceae	186801|Clostridia	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
DEZH2_k127_3667601_2	203119.Cthe_2369	1.79e-22	100.0	COG0594@1|root,COG0594@2|Bacteria,1VA78@1239|Firmicutes,24QK5@186801|Clostridia,3WKGV@541000|Ruminococcaceae	186801|Clostridia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
DEZH2_k127_3683660_2	1304880.JAGB01000001_gene293	4.913e-05	47.0	COG0124@1|root,COG0124@2|Bacteria,1UIUT@1239|Firmicutes,25ESP@186801|Clostridia	186801|Clostridia	J	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
DEZH2_k127_3683660_0	1408422.JHYF01000013_gene505	3.472e-47	181.0	28IUJ@1|root,2Z8T8@2|Bacteria,1W5W7@1239|Firmicutes,25E72@186801|Clostridia,36UMA@31979|Clostridiaceae	186801|Clostridia	S	Putative ATP-binding cassette	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
DEZH2_k127_3724491_0	1122919.KB905584_gene3897	3.951e-45	181.0	COG1653@1|root,COG1653@2|Bacteria,1TPWV@1239|Firmicutes,4HEIR@91061|Bacilli,275IK@186822|Paenibacillaceae	91061|Bacilli	G	Extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	DUF3502,SBP_bac_1,SBP_bac_8
DEZH2_k127_3724491_1	1280680.AUJU01000008_gene160	5.875e-21	96.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V8U9@1239|Firmicutes,24J0N@186801|Clostridia,4C0Y8@830|Butyrivibrio	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC,Response_reg
DEZH2_k127_3770086_1	1392491.JIAE01000001_gene1348	5.115e-69	235.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,3WGG9@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
DEZH2_k127_3770086_0	1291050.JAGE01000001_gene500	1.723e-201	637.0	COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia,3WGBU@541000|Ruminococcaceae	186801|Clostridia	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
DEZH2_k127_3773032_2	1408422.JHYF01000004_gene1708	7.561e-86	292.0	COG2265@1|root,COG2265@2|Bacteria	2|Bacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rsmJ	-	2.1.1.11,2.1.1.242	ko:K03428,ko:K07003,ko:K15984	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R04237	RC00003,RC00460	ko00000,ko00001,ko01000,ko03009	-	-	-	Methyltransf_21,Methyltransf_25,Methyltransf_31,rRNA_methylase
DEZH2_k127_3773032_1	1410668.JNKC01000005_gene2180	3.194e-181	583.0	COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,36UQ3@31979|Clostridiaceae	186801|Clostridia	I	long-chain acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
DEZH2_k127_3773032_0	1280668.ATVT01000011_gene3302	6.034e-256	813.0	COG2207@1|root,COG3664@1|root,COG2207@2|Bacteria,COG3664@2|Bacteria,1TQGI@1239|Firmicutes,2490Q@186801|Clostridia,4BXID@830|Butyrivibrio	186801|Clostridia	G	Glycosyl hydrolases family 39	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Glyco_hydro_39,HTH_18
DEZH2_k127_3780884_2	1415775.U729_948	3.138e-102	346.0	COG1807@1|root,COG1807@2|Bacteria,1V693@1239|Firmicutes,24M9H@186801|Clostridia	186801|Clostridia	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
DEZH2_k127_3780884_5	742723.HMPREF9477_01664	6.991e-40	154.0	COG1956@1|root,COG1956@2|Bacteria,1V6GQ@1239|Firmicutes,24J9S@186801|Clostridia,27NI4@186928|unclassified Lachnospiraceae	186801|Clostridia	T	GAF domain	-	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF,GAF_2
DEZH2_k127_3780884_4	755731.Clo1100_2101	3.443e-45	167.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24P0N@186801|Clostridia,36UCP@31979|Clostridiaceae	186801|Clostridia	S	CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
DEZH2_k127_3780884_0	556261.HMPREF0240_00633	6.583e-128	416.0	COG0716@1|root,COG0716@2|Bacteria,1VF5I@1239|Firmicutes	1239|Firmicutes	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
DEZH2_k127_3780884_1	632518.Calow_1759	6.611e-108	369.0	COG2272@1|root,COG2272@2|Bacteria,1UXY5@1239|Firmicutes,249A6@186801|Clostridia	186801|Clostridia	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase,Glyco_hydro_43
DEZH2_k127_3780884_7	1033737.CAEV01000112_gene3434	9.162e-13	72.0	COG1359@1|root,COG1359@2|Bacteria,1VJ7Y@1239|Firmicutes,24RJ7@186801|Clostridia,36MX3@31979|Clostridiaceae	186801|Clostridia	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
DEZH2_k127_3780884_6	931626.Awo_c04160	1.015e-13	84.0	COG2508@1|root,COG2508@2|Bacteria,1VC60@1239|Firmicutes,24KVR@186801|Clostridia	186801|Clostridia	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
DEZH2_k127_3780884_3	1131462.DCF50_p2414	2.437e-66	238.0	COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia,26302@186807|Peptococcaceae	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DEZH2_k127_3784160_1	1291050.JAGE01000001_gene1371	5.115e-144	462.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia,3WGZC@541000|Ruminococcaceae	186801|Clostridia	E	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
DEZH2_k127_3784160_3	1195236.CTER_3312	3.212e-15	76.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,25E6I@186801|Clostridia,3WI37@541000|Ruminococcaceae	186801|Clostridia	E	PFAM Cys Met metabolism	mccB	-	2.5.1.48,4.4.1.8	ko:K01739,ko:K01760	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
DEZH2_k127_3784160_0	1121335.Clst_1891	2.328e-157	501.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,25E6I@186801|Clostridia,3WI37@541000|Ruminococcaceae	186801|Clostridia	E	PFAM Cys Met metabolism	mccB	-	2.5.1.48,4.4.1.8	ko:K01739,ko:K01760	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
DEZH2_k127_3784160_2	1105031.HMPREF1141_3206	7.365e-58	204.0	COG1959@1|root,COG1959@2|Bacteria,1V6RP@1239|Firmicutes,24KGB@186801|Clostridia,36K3U@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
DEZH2_k127_3784160_4	994573.T472_0205440	1.772e-12	68.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,36EJD@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DEZH2_k127_3793054_6	138119.DSY2873	3.44e-48	181.0	COG2081@1|root,COG2081@2|Bacteria,1TR7U@1239|Firmicutes,2497W@186801|Clostridia,2616Y@186807|Peptococcaceae	186801|Clostridia	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
DEZH2_k127_3793054_11	637389.Acaty_c1975	6.761e-18	92.0	COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,1RMP4@1236|Gammaproteobacteria,2NCK5@225057|Acidithiobacillales	225057|Acidithiobacillales	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
DEZH2_k127_3793054_1	498761.HM1_0557	4.368e-172	559.0	COG1164@1|root,COG1164@2|Bacteria,1TP4P@1239|Firmicutes,248TP@186801|Clostridia	186801|Clostridia	E	Oligoendopeptidase f	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
DEZH2_k127_3793054_9	588581.Cpap_1970	2.746e-32	143.0	2DBSS@1|root,2ZATI@2|Bacteria,1V481@1239|Firmicutes,24C13@186801|Clostridia,3WICM@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
DEZH2_k127_3793054_4	720554.Clocl_0641	8.401e-59	224.0	COG3225@1|root,COG3225@2|Bacteria,1TT1J@1239|Firmicutes,24BC2@186801|Clostridia,3WIU9@541000|Ruminococcaceae	186801|Clostridia	N	transport system	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_transp_aux
DEZH2_k127_3793054_5	1121335.Clst_0897	1.818e-48	184.0	COG1277@1|root,COG1277@2|Bacteria,1UZXS@1239|Firmicutes,248ME@186801|Clostridia,3WI9V@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_5
DEZH2_k127_3793054_3	1392491.JIAE01000001_gene1332	1.636e-119	391.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,3WH5S@541000|Ruminococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_3793054_7	1392491.JIAE01000001_gene1331	4.132e-34	141.0	COG3884@1|root,COG3884@2|Bacteria	2|Bacteria	I	thiolester hydrolase activity	-	-	3.1.2.21	ko:K01071	ko00061,ko01100,map00061,map01100	-	R04014,R08157,R08158	RC00014,RC00039	ko00000,ko00001,ko01000,ko01004	-	-	-	Acyl-ACP_TE
DEZH2_k127_3793054_2	1395513.P343_15425	3.11e-167	542.0	COG2270@1|root,COG2270@2|Bacteria,1TRTH@1239|Firmicutes,4H9VB@91061|Bacilli	91061|Bacilli	S	COG2270 Permeases of the major facilitator superfamily	yxiO	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
DEZH2_k127_3793054_8	588581.Cpap_2062	1.559e-32	134.0	2E823@1|root,332G5@2|Bacteria,1V8A8@1239|Firmicutes,24S4J@186801|Clostridia,3WKR3@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3793054_0	509191.AEDB02000042_gene4888	9.101e-267	829.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,3WGUG@541000|Ruminococcaceae	186801|Clostridia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
DEZH2_k127_3813619_2	1123288.SOV_6c01970	1.372e-69	245.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,4H232@909932|Negativicutes	909932|Negativicutes	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
DEZH2_k127_3813619_5	699246.HMPREF0868_0665	2.055e-30	125.0	COG4443@1|root,COG4443@2|Bacteria,1VEFE@1239|Firmicutes,24QV3@186801|Clostridia	186801|Clostridia	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	PC4
DEZH2_k127_3813619_3	1291050.JAGE01000001_gene2712	2.464e-50	191.0	COG1408@1|root,COG1408@2|Bacteria,1UU17@1239|Firmicutes,248PS@186801|Clostridia,3WGVG@541000|Ruminococcaceae	186801|Clostridia	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
DEZH2_k127_3813619_1	537013.CLOSTMETH_03685	1.257e-87	306.0	COG1653@1|root,COG1653@2|Bacteria,1TRST@1239|Firmicutes,24APZ@186801|Clostridia,3WI9M@541000|Ruminococcaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
DEZH2_k127_3813619_6	1392491.JIAE01000001_gene663	4.854e-22	105.0	COG1989@1|root,COG1989@2|Bacteria,1VMQF@1239|Firmicutes,24VEC@186801|Clostridia	186801|Clostridia	NOU	Type IV leader peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_A24
DEZH2_k127_3813619_8	1284708.HMPREF1634_05180	0.0001061	54.0	COG1266@1|root,COG1266@2|Bacteria,1V1B4@1239|Firmicutes,25CEY@186801|Clostridia	186801|Clostridia	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
DEZH2_k127_3813619_4	1392491.JIAE01000001_gene661	4.479e-48	192.0	COG0628@1|root,COG0628@2|Bacteria,1TS4S@1239|Firmicutes,248E5@186801|Clostridia,3WJEJ@541000|Ruminococcaceae	186801|Clostridia	S	sporulation integral membrane protein YtvI	ytvI	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
DEZH2_k127_3813619_0	509191.AEDB02000108_gene1602	3.9e-140	456.0	COG0826@1|root,COG0826@2|Bacteria,1TPRE@1239|Firmicutes,248I3@186801|Clostridia,3WGFB@541000|Ruminococcaceae	186801|Clostridia	O	Peptidase U32	yegQ	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
DEZH2_k127_3813619_7	1123288.SOV_4c01360	1.181e-20	95.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,4H20Z@909932|Negativicutes	909932|Negativicutes	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
DEZH2_k127_3836826_2	592028.GCWU000321_00262	2.036e-17	94.0	COG0614@1|root,COG0614@2|Bacteria,1V1QH@1239|Firmicutes,4H41G@909932|Negativicutes	909932|Negativicutes	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
DEZH2_k127_3836826_0	755731.Clo1100_3857	1.118e-84	292.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,36EB1@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	yvrB	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
DEZH2_k127_3836826_1	1291050.JAGE01000001_gene1386	9.839e-56	203.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,3WHJY@541000|Ruminococcaceae	186801|Clostridia	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
DEZH2_k127_3849059_9	1195236.CTER_2336	5.035e-24	103.0	COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia,3WG83@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N,PyrI_C
DEZH2_k127_3849059_5	1195236.CTER_2337	1.72e-73	252.0	COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,24FQD@186801|Clostridia,3WIVY@541000|Ruminococcaceae	186801|Clostridia	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	iHN637.CLJU_RS05275	Pribosyltran
DEZH2_k127_3849059_11	1448860.BBJO01000030_gene283	1.162e-08	67.0	COG2248@1|root,arCOG10198@2157|Archaea,2XVNM@28890|Euryarchaeota,23TKW@183963|Halobacteria	183963|Halobacteria	S	Putative, 10TM heavy-metal exporter	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_2
DEZH2_k127_3849059_1	2423.NA23_0210395	1.737e-145	469.0	COG0562@1|root,COG0562@2|Bacteria,2GDZ9@200918|Thermotogae	200918|Thermotogae	M	UDP-galactopyranose mutase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,NAD_binding_8
DEZH2_k127_3849059_10	509191.AEDB02000003_gene1019	1.858e-09	61.0	2DPV4@1|root,333HA@2|Bacteria,1VH7Z@1239|Firmicutes,24SC2@186801|Clostridia,3WQ8C@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3849059_7	720554.Clocl_3488	7.88e-64	226.0	COG2267@1|root,COG2267@2|Bacteria,1V3S1@1239|Firmicutes,24GGH@186801|Clostridia,3WIHR@541000|Ruminococcaceae	186801|Clostridia	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_5
DEZH2_k127_3849059_8	1195236.CTER_4194	8.263e-33	143.0	COG2207@1|root,COG2207@2|Bacteria,1V029@1239|Firmicutes,24CBP@186801|Clostridia	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
DEZH2_k127_3849059_0	1304865.JAGF01000001_gene2243	1.632e-196	625.0	COG1053@1|root,COG1053@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
DEZH2_k127_3849059_3	646529.Desaci_2340	9.939e-115	376.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia,261F6@186807|Peptococcaceae	186801|Clostridia	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
DEZH2_k127_3849059_6	643648.Slip_0579	8.891e-70	245.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia	186801|Clostridia	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
DEZH2_k127_3849059_4	1307436.PBF_11482	1.262e-79	274.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,4HB6V@91061|Bacilli,1ZB50@1386|Bacillus	91061|Bacilli	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
DEZH2_k127_3849059_2	138119.DSY4732	7.112e-129	415.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,266YR@186807|Peptococcaceae	186801|Clostridia	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	1.14.14.9,4.2.1.120,5.3.3.3	ko:K00483,ko:K14534	ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220	M00374,M00375	R02698,R03031,R03299,R10782	RC00046,RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
DEZH2_k127_3851120_0	720554.Clocl_2755	2.164e-253	789.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,3WG9W@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DEZH2_k127_3886146_0	203275.BFO_0442	1.4e-240	750.0	COG0362@1|root,COG0362@2|Bacteria,4NG05@976|Bacteroidetes,2FMFW@200643|Bacteroidia,22WS9@171551|Porphyromonadaceae	976|Bacteroidetes	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
DEZH2_k127_3886146_1	1304880.JAGB01000001_gene981	9.115e-183	580.0	COG3875@1|root,COG3875@2|Bacteria,1UYM4@1239|Firmicutes,24AR5@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
DEZH2_k127_3886146_2	385682.AFSL01000072_gene1322	3.352e-25	106.0	COG0524@1|root,COG0524@2|Bacteria,4NH8K@976|Bacteroidetes,2FM8P@200643|Bacteroidia,3XIZT@558415|Marinilabiliaceae	976|Bacteroidetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
DEZH2_k127_3886651_4	768706.Desor_1044	4.37e-31	127.0	COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,248DE@186801|Clostridia,2606Y@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
DEZH2_k127_3886651_0	398512.JQKC01000011_gene335	7.541e-179	579.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,3WGVF@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
DEZH2_k127_3886651_1	699246.HMPREF0868_1231	5.831e-65	232.0	COG0061@1|root,COG0061@2|Bacteria,1TRB3@1239|Firmicutes,24BG6@186801|Clostridia,2680A@186813|unclassified Clostridiales	186801|Clostridia	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS05480	NAD_kinase
DEZH2_k127_3886651_3	1410638.JHXJ01000002_gene1341	6.344e-40	155.0	COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,24HGQ@186801|Clostridia,3WJZ0@541000|Ruminococcaceae	186801|Clostridia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
DEZH2_k127_3886651_2	1291050.JAGE01000001_gene2	5.345e-43	162.0	COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia,3WHDP@541000|Ruminococcaceae	186801|Clostridia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
DEZH2_k127_3886651_5	1408323.JQKK01000017_gene2912	7.106e-09	60.0	COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia,27ITD@186928|unclassified Lachnospiraceae	186801|Clostridia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
DEZH2_k127_3888355_3	290402.Cbei_3779	7.405e-47	171.0	COG1053@1|root,COG1053@2|Bacteria,1TT1Q@1239|Firmicutes,249N4@186801|Clostridia,36FZX@31979|Clostridiaceae	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
DEZH2_k127_3888355_1	1158607.UAU_04199	1.184e-96	326.0	COG1082@1|root,COG1082@2|Bacteria,1TZBT@1239|Firmicutes,4I84X@91061|Bacilli,4B2UN@81852|Enterococcaceae	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_3888355_4	69328.PVLB_10645	6.846e-22	100.0	COG1082@1|root,COG1082@2|Bacteria,1RFAW@1224|Proteobacteria,1S4VR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3888355_2	580327.Tthe_0640	8.85e-55	205.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,42FY5@68295|Thermoanaerobacterales	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	-	-	5.1.1.1	ko:K01775,ko:K02529,ko:K05499	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011,ko03000	-	-	-	LacI,Peripla_BP_3
DEZH2_k127_3888355_0	33035.JPJF01000049_gene630	1.551e-184	580.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,24XW6@186801|Clostridia,3XYRM@572511|Blautia	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_3919336_1	1410638.JHXJ01000027_gene1164	5.329e-58	206.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,3WIX7@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
DEZH2_k127_3919336_0	994573.T472_0206080	1.395e-96	326.0	COG1102@1|root,COG1102@2|Bacteria,1V4Q1@1239|Firmicutes,24IJ0@186801|Clostridia,36PDN@31979|Clostridiaceae	186801|Clostridia	F	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
DEZH2_k127_3934675_1	1423321.AS29_10565	6.939e-05	52.0	COG3764@1|root,COG3764@2|Bacteria,1UN9R@1239|Firmicutes,4HGDU@91061|Bacilli	91061|Bacilli	M	Sortase (surface protein transpeptidase)	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
DEZH2_k127_3934675_0	755731.Clo1100_3855	7.777e-101	349.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,36DDZ@31979|Clostridiaceae	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
DEZH2_k127_3975331_1	877415.JNJQ01000002_gene2288	8.892e-197	618.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes	1239|Firmicutes	G	hydrolase, family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
DEZH2_k127_3975331_3	877415.JNJQ01000002_gene2289	6.114e-113	371.0	COG0546@1|root,COG0546@2|Bacteria,1V1RB@1239|Firmicutes	1239|Firmicutes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
DEZH2_k127_3975331_2	1291050.JAGE01000001_gene1869	8.978e-175	559.0	COG1904@1|root,COG1904@2|Bacteria,1TRI0@1239|Firmicutes,248C0@186801|Clostridia,3WH1J@541000|Ruminococcaceae	186801|Clostridia	G	glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
DEZH2_k127_3975331_0	264732.Moth_0429	4.42e-208	659.0	COG0246@1|root,COG0246@2|Bacteria,1TQ97@1239|Firmicutes,247TG@186801|Clostridia,42FDZ@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Mannitol dehydrogenase	-	-	1.1.1.57	ko:K00040	ko00040,ko01100,map00040,map01100	M00061	R02454	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
DEZH2_k127_4014620_2	536227.CcarbDRAFT_1789	6.663e-09	69.0	2BNX7@1|root,32HM6@2|Bacteria,1V9A7@1239|Firmicutes,24HSM@186801|Clostridia,36KBF@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4014620_1	1378168.N510_01861	2.83e-16	93.0	COG4219@1|root,COG4219@2|Bacteria,1TQ0K@1239|Firmicutes	1239|Firmicutes	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	DUF4825,DUF5301,Peptidase_M23,Peptidase_M56
DEZH2_k127_4014620_0	290397.Adeh_0883	7.561e-19	89.0	COG0457@1|root,COG0457@2|Bacteria,1N4HS@1224|Proteobacteria,43753@68525|delta/epsilon subdivisions,2X219@28221|Deltaproteobacteria,2Z10F@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11
DEZH2_k127_4016135_8	697282.Mettu_0542	0.0001697	46.0	COG3861@1|root,COG3861@2|Bacteria,1RD6Y@1224|Proteobacteria,1S4FS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	PRC
DEZH2_k127_4016135_6	1195236.CTER_5033	1.412e-32	130.0	COG2832@1|root,COG2832@2|Bacteria,1V6I1@1239|Firmicutes,24U8T@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF454)	-	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
DEZH2_k127_4016135_1	398512.JQKC01000028_gene3881	3.825e-98	327.0	COG1030@1|root,COG1030@2|Bacteria,1V6UR@1239|Firmicutes,24D2S@186801|Clostridia,3WNWF@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
DEZH2_k127_4016135_7	1123318.KB904632_gene1202	2.922e-14	79.0	arCOG09454@1|root,30G4A@2|Bacteria,1V448@1239|Firmicutes,4HHA0@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4016135_3	994573.T472_0215350	1.327e-90	303.0	COG1309@1|root,COG1309@2|Bacteria,1VDSK@1239|Firmicutes,24MTE@186801|Clostridia,36JUY@31979|Clostridiaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
DEZH2_k127_4016135_5	378806.STAUR_8083	1.406e-51	190.0	COG2085@1|root,COG2085@2|Bacteria,1NI54@1224|Proteobacteria	1224|Proteobacteria	S	NADP oxidoreductase coenzyme F420-dependent	npdG	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
DEZH2_k127_4016135_4	1232410.KI421413_gene953	4.033e-78	269.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,43UZQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Ku70/Ku80 beta-barrel domain	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
DEZH2_k127_4016135_0	913865.DOT_5118	1.02e-246	775.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1TSAC@1239|Firmicutes,25EIJ@186801|Clostridia,261GW@186807|Peptococcaceae	186801|Clostridia	L	Eukaryotic and archaeal DNA primase small subunit	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
DEZH2_k127_4042771_1	1158601.I585_04545	2.354e-18	89.0	COG0526@1|root,COG0526@2|Bacteria,1VEYC@1239|Firmicutes,4HPG7@91061|Bacilli	91061|Bacilli	CO	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
DEZH2_k127_4042771_0	545243.BAEV01000051_gene3766	3.356e-210	667.0	COG0446@1|root,COG0446@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36EYM@31979|Clostridiaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Pyr_redox_dim,Rhodanese
DEZH2_k127_4042771_2	1487921.DP68_05775	7.112e-06	48.0	COG0798@1|root,COG0798@2|Bacteria,1TRMD@1239|Firmicutes,24958@186801|Clostridia,36FGQ@31979|Clostridiaceae	186801|Clostridia	P	TIGRFAM Arsenical-resistance protein	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
DEZH2_k127_4043860_1	33905.BTHE_1191	1.013e-06	56.0	COG0726@1|root,COG0726@2|Bacteria,2GN6G@201174|Actinobacteria,4D08Y@85004|Bifidobacteriales	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	3.2.1.8,3.5.1.104	ko:K01181,ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
DEZH2_k127_4043860_0	1519439.JPJG01000054_gene2145	2.784e-86	289.0	COG1139@1|root,COG1139@2|Bacteria,1V4FE@1239|Firmicutes,24DW6@186801|Clostridia,2N8X9@216572|Oscillospiraceae	186801|Clostridia	C	LUD domain	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
DEZH2_k127_4049411_0	699246.HMPREF0868_0863	9.51e-185	582.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,267ZX@186813|unclassified Clostridiales	186801|Clostridia	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
DEZH2_k127_4049411_1	699246.HMPREF0868_0862	1.297e-139	451.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,268H6@186813|unclassified Clostridiales	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
DEZH2_k127_4049411_2	1123288.SOV_3c07840	1.049e-55	198.0	COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,4H2BR@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
DEZH2_k127_4053712_0	1042156.CXIVA_07070	7.144e-135	435.0	COG3246@1|root,COG3246@2|Bacteria,1UYNM@1239|Firmicutes,24C69@186801|Clostridia	186801|Clostridia	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
DEZH2_k127_4053712_1	1461582.BN1048_00155	1.053e-34	142.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,4GYWT@90964|Staphylococcaceae	91061|Bacilli	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
DEZH2_k127_4062108_6	1410668.JNKC01000009_gene2555	1.348e-14	74.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,36EK4@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_4062108_0	994573.T472_0205580	1.539e-253	820.0	COG0577@1|root,COG1511@1|root,COG0577@2|Bacteria,COG1511@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia,36E94@31979|Clostridiaceae	186801|Clostridia	V	Permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DEZH2_k127_4062108_4	1410668.JNKC01000009_gene2557	8.968e-46	174.0	COG1309@1|root,COG1309@2|Bacteria,1TPXF@1239|Firmicutes,24F9Q@186801|Clostridia,36N3C@31979|Clostridiaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
DEZH2_k127_4062108_1	1120998.AUFC01000035_gene1270	2.307e-156	499.0	COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,247RH@186801|Clostridia,3WCSR@538999|Clostridiales incertae sedis	186801|Clostridia	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
DEZH2_k127_4062108_3	398512.JQKC01000001_gene2483	8.6e-51	186.0	COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia,3WJ0F@541000|Ruminococcaceae	186801|Clostridia	E	Acetolactate synthase small	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
DEZH2_k127_4062108_5	1123009.AUID01000003_gene1902	1.078e-34	137.0	COG1970@1|root,COG1970@2|Bacteria,1VA14@1239|Firmicutes,24JAB@186801|Clostridia,269KW@186813|unclassified Clostridiales	186801|Clostridia	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
DEZH2_k127_4062108_2	1196095.GAPWK_1744	5.236e-72	246.0	COG4277@1|root,COG4277@2|Bacteria,1MVCV@1224|Proteobacteria,1RY4T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DNA-binding protein with the Helix-hairpin-helix motif	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Radical_SAM
DEZH2_k127_40798_2	411460.RUMTOR_00775	5.122e-103	342.0	COG0524@1|root,COG0524@2|Bacteria,1TRRY@1239|Firmicutes,25BA0@186801|Clostridia	186801|Clostridia	G	belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
DEZH2_k127_40798_3	1120746.CCNL01000004_gene34	1.655e-62	224.0	COG1349@1|root,COG1349@2|Bacteria,2NPT7@2323|unclassified Bacteria	2|Bacteria	K	DeoR C terminal sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
DEZH2_k127_40798_0	1487921.DP68_16700	8.011e-204	643.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,24C9J@186801|Clostridia,36F9D@31979|Clostridiaceae	186801|Clostridia	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
DEZH2_k127_40798_1	1487921.DP68_16710	1.002e-170	539.0	COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes,24DB5@186801|Clostridia,36HV5@31979|Clostridiaceae	186801|Clostridia	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
DEZH2_k127_40798_4	1487921.DP68_16705	2.127e-32	126.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,36E3Q@31979|Clostridiaceae	186801|Clostridia	E	Dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N,Glu_dehyd_C
DEZH2_k127_4162092_4	767817.Desgi_3508	7.479e-99	327.0	COG2304@1|root,COG2304@2|Bacteria,1TRPP@1239|Firmicutes,249HV@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	VWA
DEZH2_k127_4162092_6	1200557.JHWV01000013_gene1296	3.259e-54	200.0	COG3741@1|root,COG3741@2|Bacteria	2|Bacteria	E	N-formylglutamate amidohydrolase	hutG	-	3.5.3.8	ko:K01479	ko00340,ko01100,map00340,map01100	M00045	R02285	RC00221,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	FGase
DEZH2_k127_4162092_2	871968.DESME_05135	5.878e-133	429.0	COG1741@1|root,COG1741@2|Bacteria,1TQDV@1239|Firmicutes,2497R@186801|Clostridia,263S8@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
DEZH2_k127_4162092_9	768704.Desmer_2835	1.01e-41	156.0	COG1695@1|root,COG1695@2|Bacteria,1UHRK@1239|Firmicutes,25F64@186801|Clostridia,267FZ@186807|Peptococcaceae	186801|Clostridia	K	Domain of unknown function (DUF4180)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4180,PadR,Vir_act_alpha_C
DEZH2_k127_4162092_8	1449050.JNLE01000003_gene2110	2.498e-48	184.0	COG0583@1|root,COG0583@2|Bacteria,1TST3@1239|Firmicutes,24CMV@186801|Clostridia,36II5@31979|Clostridiaceae	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
DEZH2_k127_4162092_7	478749.BRYFOR_06821	5.577e-52	197.0	COG2755@1|root,COG2755@2|Bacteria,1V4VT@1239|Firmicutes	1239|Firmicutes	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
DEZH2_k127_4162092_10	1122927.KB895412_gene1014	2.885e-28	119.0	COG3815@1|root,COG3815@2|Bacteria,1VFP9@1239|Firmicutes,4HPXS@91061|Bacilli	91061|Bacilli	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
DEZH2_k127_4162092_11	290402.Cbei_3297	1.867e-22	98.0	2DS2C@1|root,33E7H@2|Bacteria,1VM6D@1239|Firmicutes,25JFW@186801|Clostridia,36M4C@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4162092_3	243231.GSU0168	3.833e-109	364.0	COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,42MWV@68525|delta/epsilon subdivisions,2WJJZ@28221|Deltaproteobacteria,43SI6@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Fic/DOC family N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N,HTH_24
DEZH2_k127_4162092_0	1131462.DCF50_p788	4.845e-227	719.0	COG0477@1|root,COG2814@2|Bacteria,1VSW8@1239|Firmicutes,25ET5@186801|Clostridia,265II@186807|Peptococcaceae	186801|Clostridia	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
DEZH2_k127_4162092_1	158190.SpiGrapes_3088	1.922e-165	538.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	-	-	1.3.99.23,5.2.1.13	ko:K09516,ko:K09835	ko00830,ko00906,ko01100,ko01110,map00830,map00906,map01100,map01110	M00097	R07163,R07512	RC01835,RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
DEZH2_k127_4162092_5	158190.SpiGrapes_3087	1.17e-60	212.0	COG0493@1|root,COG1233@1|root,COG0493@2|Bacteria,COG1233@2|Bacteria,2J838@203691|Spirochaetes	203691|Spirochaetes	Q	Flavin containing amine oxidoreductase	-	-	1.3.99.23,5.2.1.13	ko:K09516,ko:K09835	ko00830,ko00906,ko01100,ko01110,map00830,map00906,map01100,map01110	M00097	R07163,R07512	RC01835,RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
DEZH2_k127_4162656_2	1410638.JHXJ01000012_gene2637	4.796e-53	191.0	COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia,3WH0Q@541000|Ruminococcaceae	186801|Clostridia	C	alcohol dehydrogenase	-	-	-	ko:K19955	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
DEZH2_k127_4162656_0	699246.HMPREF0868_0765	1.965e-264	824.0	COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,247Y0@186801|Clostridia,267XP@186813|unclassified Clostridiales	186801|Clostridia	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
DEZH2_k127_4162656_1	428125.CLOLEP_01561	5.342e-207	654.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,3WGJQ@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
DEZH2_k127_4162656_3	457396.CSBG_02147	1.068e-43	170.0	2A16J@1|root,30PCK@2|Bacteria,1UPNY@1239|Firmicutes,25HKA@186801|Clostridia,36VB7@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4162656_4	1410632.JHWW01000009_gene2514	4.591e-20	95.0	COG0484@1|root,COG0484@2|Bacteria,1V1GK@1239|Firmicutes,2494E@186801|Clostridia,27KQA@186928|unclassified Lachnospiraceae	186801|Clostridia	O	DnaJ molecular chaperone homology domain	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,TPR_2
DEZH2_k127_4164495_0	720554.Clocl_0473	9.224e-171	542.0	COG0673@1|root,COG0673@2|Bacteria,1VQWT@1239|Firmicutes,24ZDH@186801|Clostridia,3WN1T@541000|Ruminococcaceae	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
DEZH2_k127_4164495_1	720554.Clocl_0474	2.466e-114	374.0	COG1082@1|root,COG1082@2|Bacteria,1VXWF@1239|Firmicutes	1239|Firmicutes	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4170843_4	1216932.CM240_0069	5.89e-22	96.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,36E36@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
DEZH2_k127_4170843_2	1380763.BG53_05695	1.669e-47	175.0	COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,4HJ2V@91061|Bacilli,26XJ0@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
DEZH2_k127_4170843_1	1408437.JNJN01000007_gene906	6.207e-64	233.0	COG0077@1|root,COG0077@2|Bacteria,1TPDN@1239|Firmicutes,248G7@186801|Clostridia,25VRD@186806|Eubacteriaceae	186801|Clostridia	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
DEZH2_k127_4170843_0	398512.JQKC01000002_gene2005	3.166e-105	346.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,3WH0B@541000|Ruminococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_4170843_3	509191.AEDB02000099_gene3966	8.522e-44	173.0	28IUJ@1|root,2Z8T8@2|Bacteria,1W5W7@1239|Firmicutes,25E72@186801|Clostridia,3WG7C@541000|Ruminococcaceae	186801|Clostridia	S	Putative ATP-binding cassette	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
DEZH2_k127_4195781_0	203119.Cthe_2356	1.685e-126	411.0	COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,247IJ@186801|Clostridia,3WGEP@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12020	NadA
DEZH2_k127_4195781_2	1291050.JAGE01000001_gene143	1.239e-42	163.0	COG2135@1|root,COG2135@2|Bacteria,1TRRV@1239|Firmicutes,24GD7@186801|Clostridia,3WK2W@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
DEZH2_k127_4195781_1	1131462.DCF50_p2262	9.807e-109	360.0	COG4632@1|root,COG4632@2|Bacteria,1TR6Z@1239|Firmicutes,25B3H@186801|Clostridia	186801|Clostridia	G	Exopolysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
DEZH2_k127_4195781_4	1291050.JAGE01000002_gene3638	1.145e-15	78.0	COG1846@1|root,COG1846@2|Bacteria,1V4IP@1239|Firmicutes,25CPP@186801|Clostridia	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
DEZH2_k127_4239503_2	1349767.GJA_544	4.356e-24	102.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,475IE@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DEZH2_k127_4239503_1	1392491.JIAE01000001_gene1175	1.301e-37	147.0	COG3428@1|root,COG3428@2|Bacteria,1V9YB@1239|Firmicutes,24MQT@186801|Clostridia,3WJDY@541000|Ruminococcaceae	186801|Clostridia	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
DEZH2_k127_4239503_0	203119.Cthe_1319	2.327e-62	222.0	COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia,3WIFN@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
DEZH2_k127_4239503_3	699246.HMPREF0868_0724	3.043e-06	49.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,268MT@186813|unclassified Clostridiales	186801|Clostridia	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
DEZH2_k127_4244628_3	1235797.C816_02620	1.255e-33	132.0	COG1695@1|root,COG1695@2|Bacteria,1VESB@1239|Firmicutes,25CVC@186801|Clostridia,2N7KB@216572|Oscillospiraceae	186801|Clostridia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
DEZH2_k127_4244628_4	1280689.AUJC01000005_gene566	3.064e-12	79.0	2A88Y@1|root,30XA4@2|Bacteria,1V3M4@1239|Firmicutes,24C57@186801|Clostridia,36IC9@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF2812)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2812
DEZH2_k127_4244628_2	1120746.CCNL01000011_gene1844	4.673e-49	183.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.128,3.6.1.55	ko:K03574,ko:K03789	-	-	-	-	ko00000,ko01000,ko03009,ko03400	-	-	-	Acetyltransf_1,Acetyltransf_10,FR47
DEZH2_k127_4244628_1	86416.Clopa_2120	2.846e-55	195.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia,36FVM@31979|Clostridiaceae	186801|Clostridia	S	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
DEZH2_k127_4249044_0	3988.XP_002536358.1	3.139e-16	84.0	COG0324@1|root,KOG1384@2759|Eukaryota	2759|Eukaryota	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37	-	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	Band_7,GTP-bdg_M,GTP-bdg_N,IPPT,MMR_HSR1
DEZH2_k127_4249044_1	543913.D521_0650	1.879e-13	75.0	COG2114@1|root,COG2114@2|Bacteria,1PG87@1224|Proteobacteria,2W8ZT@28216|Betaproteobacteria,1KR50@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
DEZH2_k127_4272572_3	1123306.KB904357_gene654	2.975e-51	190.0	COG2313@1|root,COG2313@2|Bacteria,1TR5J@1239|Firmicutes,4HC38@91061|Bacilli	91061|Bacilli	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
DEZH2_k127_4272572_1	1034347.CAHJ01000074_gene2799	4.183e-80	280.0	COG0524@1|root,COG1522@1|root,COG0524@2|Bacteria,COG1522@2|Bacteria,1TQR4@1239|Firmicutes,4H9VM@91061|Bacilli,1ZBUP@1386|Bacillus	91061|Bacilli	GK	pfkB family carbohydrate kinase	fruK	-	2.7.1.83	ko:K16328	ko00240,map00240	-	R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HTH_24,PfkB
DEZH2_k127_4272572_0	1042156.CXIVA_19430	3.08e-148	480.0	COG0407@1|root,COG0407@2|Bacteria,1TRJG@1239|Firmicutes,249EI@186801|Clostridia,36SGJ@31979|Clostridiaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DEZH2_k127_4272572_2	1042156.CXIVA_19420	1.869e-61	222.0	COG0583@1|root,COG0583@2|Bacteria,1VDIV@1239|Firmicutes,24I2M@186801|Clostridia,36JNH@31979|Clostridiaceae	1042156.CXIVA_19420|-	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4303527_1	883103.HMPREF9703_00263	7.516e-20	100.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,27FZZ@186828|Carnobacteriaceae	91061|Bacilli	G	Belongs to the binding-protein-dependent transport system permease family	rbsC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_4303527_0	1408254.T458_20860	1.981e-58	216.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,26R5U@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the binding-protein-dependent transport system permease family	rbsC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_4317455_19	1410638.JHXJ01000008_gene376	9.536e-11	62.0	COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,3WHH0@541000|Ruminococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
DEZH2_k127_4317455_3	1392491.JIAE01000001_gene2496	2.787e-81	277.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,3WGQT@541000|Ruminococcaceae	186801|Clostridia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
DEZH2_k127_4317455_13	699246.HMPREF0868_1538	1.653e-40	153.0	COG0089@1|root,COG0089@2|Bacteria,1VA4W@1239|Firmicutes,24MN8@186801|Clostridia	186801|Clostridia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
DEZH2_k127_4317455_0	699246.HMPREF0868_1537	2.279e-133	429.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,267V8@186813|unclassified Clostridiales	186801|Clostridia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
DEZH2_k127_4317455_12	699246.HMPREF0868_1536	1.172e-43	160.0	COG0185@1|root,COG0185@2|Bacteria,1V6CX@1239|Firmicutes,24JN3@186801|Clostridia,269DU@186813|unclassified Clostridiales	186801|Clostridia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
DEZH2_k127_4317455_9	699246.HMPREF0868_1535	1.543e-61	215.0	COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,24JF4@186801|Clostridia,2695W@186813|unclassified Clostridiales	186801|Clostridia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
DEZH2_k127_4317455_1	699246.HMPREF0868_1534	2.825e-102	336.0	COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,24833@186801|Clostridia,2680N@186813|unclassified Clostridiales	186801|Clostridia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
DEZH2_k127_4317455_6	1226322.HMPREF1545_02728	1.709e-72	248.0	COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,2N76R@216572|Oscillospiraceae	186801|Clostridia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
DEZH2_k127_4317455_17	1392491.JIAE01000001_gene2489	1.522e-17	86.0	COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,24QV1@186801|Clostridia,3WKVV@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
DEZH2_k127_4317455_14	411469.EUBHAL_01743	2.681e-38	144.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,25WUN@186806|Eubacteriaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
DEZH2_k127_4317455_7	699246.HMPREF0868_1530	6.354e-65	223.0	COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,24H98@186801|Clostridia,26916@186813|unclassified Clostridiales	186801|Clostridia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
DEZH2_k127_4317455_15	1195236.CTER_2786	1.501e-36	141.0	COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,24MY0@186801|Clostridia,3WJBH@541000|Ruminococcaceae	186801|Clostridia	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
DEZH2_k127_4317455_2	1392491.JIAE01000001_gene2485	6.919e-93	306.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,247X0@186801|Clostridia,3WGYQ@541000|Ruminococcaceae	186801|Clostridia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
DEZH2_k127_4317455_16	862517.HMPREF9225_0163	9.311e-29	117.0	COG0199@1|root,COG0199@2|Bacteria,1VEF6@1239|Firmicutes,24QR1@186801|Clostridia	186801|Clostridia	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
DEZH2_k127_4317455_10	1392491.JIAE01000001_gene2483	1.049e-59	209.0	COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,24HCP@186801|Clostridia,3WPC7@541000|Ruminococcaceae	186801|Clostridia	J	Ribosomal protein S8	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
DEZH2_k127_4317455_5	509191.AEDB02000040_gene4606	1.461e-76	260.0	COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,2496R@186801|Clostridia,3WIFT@541000|Ruminococcaceae	186801|Clostridia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
DEZH2_k127_4317455_11	1392491.JIAE01000001_gene2481	1.056e-50	182.0	COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,24JCS@186801|Clostridia,3WJ8R@541000|Ruminococcaceae	186801|Clostridia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
DEZH2_k127_4317455_4	1291050.JAGE01000001_gene2108	3.288e-79	267.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,24G5D@186801|Clostridia,3WICZ@541000|Ruminococcaceae	186801|Clostridia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
DEZH2_k127_4317455_18	699246.HMPREF0868_1522	8.062e-14	73.0	COG1841@1|root,COG1841@2|Bacteria	2|Bacteria	J	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rpmD	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
DEZH2_k127_4317455_8	699246.HMPREF0868_1521	3.043e-62	217.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia,268S2@186813|unclassified Clostridiales	186801|Clostridia	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
DEZH2_k127_4317455_20	509191.AEDB02000040_gene4601	2.192e-09	58.0	COG0201@1|root,COG0201@2|Bacteria,1TPHB@1239|Firmicutes,248T9@186801|Clostridia,3WG8Z@541000|Ruminococcaceae	186801|Clostridia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
DEZH2_k127_431987_2	1120998.AUFC01000006_gene878	1.526e-53	210.0	COG2041@1|root,COG3867@1|root,COG4733@1|root,COG5184@1|root,COG5492@1|root,COG2041@2|Bacteria,COG3867@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria,1UNSB@1239|Firmicutes,25H3W@186801|Clostridia,3WDUT@538999|Clostridiales incertae sedis	2|Bacteria	DZ	S-layer homology domain	-	-	3.2.1.14,3.2.1.22,3.2.1.23,3.2.1.89	ko:K01183,ko:K01190,ko:K01224,ko:K07407	ko00052,ko00511,ko00520,ko00561,ko00600,ko00603,ko01100,map00052,map00511,map00520,map00561,map00600,map00603,map01100	-	R01101,R01103,R01104,R01105,R01194,R01206,R01329,R01678,R02334,R02926,R03355,R03634,R04019,R04470,R04783,R05549,R05961,R06091,R06114	RC00049,RC00059,RC00451,RC00452,RC00467	ko00000,ko00001,ko01000	-	GH18	-	Big_2,F5_F8_type_C,Glyco_hydro_53,RCC1,RicinB_lectin_2,SLH,fn3
DEZH2_k127_431987_3	1552123.EP57_01390	3.097e-11	76.0	COG4907@1|root,COG4907@2|Bacteria,1TS3Q@1239|Firmicutes,4HF7D@91061|Bacilli	91061|Bacilli	S	the current gene model (or a revised gene model) may contain a frame shift	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
DEZH2_k127_431987_1	931276.Cspa_c29070	2.551e-66	235.0	COG0491@1|root,COG0491@2|Bacteria,1V3ZB@1239|Firmicutes,24G09@186801|Clostridia	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DEZH2_k127_431987_0	1035308.AQYY01000001_gene3504	1.493e-102	346.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,2608N@186807|Peptococcaceae	186801|Clostridia	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	2.3.1.40,6.2.1.20,6.2.1.3,6.2.1.48	ko:K01897,ko:K02182,ko:K05939	ko00061,ko00071,ko00564,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00564,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280,R01406,R04864	RC00004,RC00014,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
DEZH2_k127_4327803_0	1410638.JHXJ01000033_gene28	1.449e-311	965.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia,3WH0Y@541000|Ruminococcaceae	186801|Clostridia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
DEZH2_k127_4332765_1	1122917.KB899666_gene3354	2.153e-54	195.0	COG5337@1|root,COG5337@2|Bacteria,1U0PJ@1239|Firmicutes,4HA85@91061|Bacilli,26QW0@186822|Paenibacillaceae	91061|Bacilli	M	Spore coat protein CotH	-	-	-	-	-	-	-	-	-	-	-	-	CotH
DEZH2_k127_4332765_0	1345695.CLSA_c21450	8.189e-156	502.0	COG3275@1|root,COG3437@1|root,COG3275@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD_5,PAS,PAS_4
DEZH2_k127_4344270_1	1105031.HMPREF1141_1882	2.635e-22	102.0	COG0679@1|root,COG0679@2|Bacteria,1UY4N@1239|Firmicutes,25CBA@186801|Clostridia,36WSU@31979|Clostridiaceae	186801|Clostridia	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
DEZH2_k127_4344270_0	316274.Haur_1250	1.982e-65	239.0	COG0477@1|root,COG2814@2|Bacteria,2G7YK@200795|Chloroflexi,376E9@32061|Chloroflexia	32061|Chloroflexia	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1
DEZH2_k127_4355831_0	1410612.JNKO01000005_gene1024	1.548e-147	473.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
DEZH2_k127_4355831_1	537013.CLOSTMETH_00790	2.435e-59	217.0	COG1073@1|root,COG1073@2|Bacteria,1V3U9@1239|Firmicutes,24IWS@186801|Clostridia,3WMHG@541000|Ruminococcaceae	186801|Clostridia	S	Prolyl oligopeptidase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	AXE1,Abhydrolase_1,Hydrolase_4
DEZH2_k127_4385044_2	1410617.JHXH01000002_gene1946	1.947e-67	237.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,3WHBA@541000|Ruminococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
DEZH2_k127_4385044_0	537013.CLOSTMETH_00734	6.904e-126	412.0	COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,24831@186801|Clostridia,3WGKK@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	fabK	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iHN637.CLJU_RS20775	NMO
DEZH2_k127_4385044_1	645991.Sgly_3033	1.062e-76	264.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,260VS@186807|Peptococcaceae	186801|Clostridia	IQ	PFAM short chain dehydrogenase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
DEZH2_k127_4393120_2	1094980.Mpsy_2377	2.566e-66	240.0	COG0675@1|root,arCOG00684@2157|Archaea,2Y38N@28890|Euryarchaeota,2NAM7@224756|Methanomicrobia	224756|Methanomicrobia	L	Probable transposase	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
DEZH2_k127_4393120_0	699246.HMPREF0868_1493	2.459e-179	566.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,268FY@186813|unclassified Clostridiales	186801|Clostridia	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
DEZH2_k127_4393120_1	1536770.R50345_07995	1.587e-133	431.0	28H6R@1|root,2Z7J3@2|Bacteria,1TQ2I@1239|Firmicutes,4HCYQ@91061|Bacilli,26UIN@186822|Paenibacillaceae	91061|Bacilli	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4393120_3	1230342.CTM_06811	7.655e-40	149.0	COG0375@1|root,COG0375@2|Bacteria,1V8EK@1239|Firmicutes,25CVT@186801|Clostridia,36JK2@31979|Clostridiaceae	186801|Clostridia	S	Hydrogenase/urease nickel incorporation, metallochaperone, hypA	-	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
DEZH2_k127_4414457_4	394503.Ccel_3480	1.957e-17	84.0	COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,247IJ@186801|Clostridia,36E6G@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12020	NadA
DEZH2_k127_4414457_2	285514.JNWO01000027_gene2264	9.522e-43	168.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
DEZH2_k127_4414457_1	931626.Awo_c03140	8.083e-46	169.0	COG3304@1|root,COG3304@2|Bacteria,1VADH@1239|Firmicutes,24NFV@186801|Clostridia,25X39@186806|Eubacteriaceae	186801|Clostridia	S	Inner membrane component domain	yccF	-	-	-	-	-	-	-	-	-	-	-	YccF
DEZH2_k127_4414457_0	1449050.JNLE01000003_gene3389	4.68e-106	353.0	COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,248MV@186801|Clostridia,36EYN@31979|Clostridiaceae	186801|Clostridia	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_4414457_3	1449063.JMLS01000026_gene3799	2.443e-32	134.0	COG2199@1|root,COG3706@2|Bacteria,1V5VN@1239|Firmicutes,4HHPQ@91061|Bacilli,26TRD@186822|Paenibacillaceae	91061|Bacilli	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
DEZH2_k127_4431402_4	1209989.TepiRe1_0777	1.008e-14	75.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,42FY5@68295|Thermoanaerobacterales	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	-	-	5.1.1.1	ko:K01775,ko:K02529,ko:K05499	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011,ko03000	-	-	-	LacI,Peripla_BP_3
DEZH2_k127_4431402_1	545695.TREAZ_2536	2.228e-113	375.0	COG0673@1|root,COG0673@2|Bacteria,2J6T7@203691|Spirochaetes	203691|Spirochaetes	E	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_4431402_3	1232436.CAPF01000098_gene1003	7.472e-50	192.0	COG1879@1|root,COG1879@2|Bacteria,2HVNK@201174|Actinobacteria,4CX5U@84998|Coriobacteriia	84998|Coriobacteriia	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
DEZH2_k127_4431402_0	411459.RUMOBE_00014	1.168e-189	604.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,3XZ1W@572511|Blautia	186801|Clostridia	P	import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441,ko:K10542	ko02010,map02010	M00212,M00214	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3	-	-	ABC_tran
DEZH2_k127_4431402_2	1123304.AQYA01000035_gene947	1.686e-55	206.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli	91061|Bacilli	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_4437329_5	635013.TherJR_1611	3.59e-59	216.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,247S5@186801|Clostridia,2607U@186807|Peptococcaceae	186801|Clostridia	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
DEZH2_k127_4437329_3	1195236.CTER_0022	6.018e-97	323.0	COG4636@1|root,COG4636@2|Bacteria,1V4N9@1239|Firmicutes,24CZ1@186801|Clostridia,3WS1T@541000|Ruminococcaceae	186801|Clostridia	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
DEZH2_k127_4437329_0	1487923.DP73_10920	9.084e-288	899.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,260Y1@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
DEZH2_k127_4437329_6	1304880.JAGB01000003_gene1115	1.774e-51	185.0	COG0640@1|root,COG0640@2|Bacteria,1VA6G@1239|Firmicutes,24JCN@186801|Clostridia	186801|Clostridia	K	transcriptional regulator	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
DEZH2_k127_4437329_1	431943.CKL_1491	5.581e-205	647.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	ko:K08166	-	-	-	-	ko00000,ko02000	2.A.1.3.10	-	-	MFS_1
DEZH2_k127_4437329_7	1345023.M467_11680	1.292e-45	173.0	COG2968@1|root,COG2968@2|Bacteria	2|Bacteria	S	cellular response to heat	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
DEZH2_k127_4437329_8	101510.RHA1_ro06994	4.623e-30	123.0	COG1917@1|root,COG1917@2|Bacteria,2IIQY@201174|Actinobacteria,4G1A2@85025|Nocardiaceae	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,Cupin_3
DEZH2_k127_4437329_2	903818.KI912268_gene2903	5.335e-150	493.0	COG2936@1|root,COG2936@2|Bacteria	2|Bacteria	V	dipeptidyl-peptidase activity	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
DEZH2_k127_4437329_9	768706.Desor_2694	2.177e-15	89.0	COG2508@1|root,COG2508@2|Bacteria,1VDTX@1239|Firmicutes,24NVQ@186801|Clostridia,263GS@186807|Peptococcaceae	186801|Clostridia	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
DEZH2_k127_4437329_4	1007103.AFHW01000048_gene3444	9.363e-84	285.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,4HAGN@91061|Bacilli,26ST6@186822|Paenibacillaceae	91061|Bacilli	K	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_4452782_4	720554.Clocl_2786	7.447e-66	242.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,3WI09@541000|Ruminococcaceae	186801|Clostridia	L	exonuclease	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,ssDNA-exonuc_C
DEZH2_k127_4452782_0	699246.HMPREF0868_1337	9.37e-320	995.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,267JM@186813|unclassified Clostridiales	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
DEZH2_k127_4452782_2	720554.Clocl_0781	1.777e-127	422.0	COG2207@1|root,COG4936@1|root,COG2207@2|Bacteria,COG4936@2|Bacteria,1U23Q@1239|Firmicutes,24CZ9@186801|Clostridia,3WIZZ@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_18,HTH_AraC,PocR
DEZH2_k127_4452782_3	1291050.JAGE01000001_gene1383	8.236e-80	271.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,3WIZU@541000|Ruminococcaceae	186801|Clostridia	S	B12 binding domain	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
DEZH2_k127_4452782_1	720554.Clocl_0522	1.122e-130	423.0	COG2199@1|root,COG3706@2|Bacteria,1UHZ8@1239|Firmicutes,25E7W@186801|Clostridia,3WGN1@541000|Ruminococcaceae	186801|Clostridia	T	Diguanylate cyclase, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
DEZH2_k127_4468725_2	1408287.AXUR01000036_gene1018	1.202e-41	161.0	COG1373@1|root,COG1373@2|Bacteria,378EK@32066|Fusobacteria	32066|Fusobacteria	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143,FUR
DEZH2_k127_4468725_4	931626.Awo_c16080	1.891e-14	85.0	28ITW@1|root,2Z8SQ@2|Bacteria,1TSYI@1239|Firmicutes,24CX0@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4468725_0	246194.CHY_0489	1.517e-99	336.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,248U7@186801|Clostridia,42EZ9@68295|Thermoanaerobacterales	186801|Clostridia	H	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
DEZH2_k127_4468725_3	1457393.AZ09_10160	2.167e-29	122.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2U9BY@28211|Alphaproteobacteria,2JSV1@204441|Rhodospirillales	204441|Rhodospirillales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
DEZH2_k127_4468725_1	1304880.JAGB01000003_gene1296	2.086e-51	187.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,2492A@186801|Clostridia	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
DEZH2_k127_4535554_1	1038862.KB893807_gene2137	9.069e-113	375.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2TT3X@28211|Alphaproteobacteria,3JS7G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DEZH2_k127_4535554_0	1410638.JHXJ01000017_gene580	1.642e-158	511.0	COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia,3WGCJ@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
DEZH2_k127_4535554_2	203119.Cthe_2881	4.788e-42	156.0	COG0040@1|root,COG0040@2|Bacteria,1TSVZ@1239|Firmicutes,249AR@186801|Clostridia,3WH70@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
DEZH2_k127_4549508_5	1392491.JIAE01000001_gene1072	9.223e-20	96.0	COG2234@1|root,COG2234@2|Bacteria,1UVEY@1239|Firmicutes,2588N@186801|Clostridia,3WMA7@541000|Ruminococcaceae	186801|Clostridia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
DEZH2_k127_4549508_0	1121335.Clst_1406	1.797e-191	605.0	COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,247XK@186801|Clostridia,3WGNF@541000|Ruminococcaceae	186801|Clostridia	E	O-acetylhomoserine	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
DEZH2_k127_4549508_2	411467.BACCAP_04563	1.919e-121	411.0	COG0419@1|root,COG0419@2|Bacteria,1TPCS@1239|Firmicutes,24A22@186801|Clostridia,268J9@186813|unclassified Clostridiales	186801|Clostridia	L	Putative exonuclease SbcCD, C subunit	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,AAA_29,SbcCD_C
DEZH2_k127_4549508_3	552398.HMPREF0866_00529	2.301e-105	351.0	COG0419@1|root,COG0419@2|Bacteria,1TPCS@1239|Firmicutes,24A22@186801|Clostridia,3WG9M@541000|Ruminococcaceae	186801|Clostridia	L	exonuclease SbcC	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,AAA_29,SbcCD_C
DEZH2_k127_4549508_1	411467.BACCAP_04564	3.049e-169	539.0	COG0420@1|root,COG0420@2|Bacteria,1TQY6@1239|Firmicutes,248VE@186801|Clostridia,2692D@186813|unclassified Clostridiales	186801|Clostridia	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
DEZH2_k127_4549508_4	552396.HMPREF0863_02260	2.801e-22	107.0	COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1TQ2W@1239|Firmicutes,3VP91@526524|Erysipelotrichia	526524|Erysipelotrichia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18,HTH_AraC
DEZH2_k127_4549508_6	697284.ERIC2_c12800	2.818e-12	79.0	COG1686@1|root,COG1686@2|Bacteria,1TQN0@1239|Firmicutes,4HBCE@91061|Bacilli,26QSM@186822|Paenibacillaceae	91061|Bacilli	M	Belongs to the peptidase S11 family	dacF	GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
DEZH2_k127_4549508_7	1347392.CCEZ01000011_gene2473	3.217e-06	55.0	2DQ8Z@1|root,335CG@2|Bacteria,1V9R5@1239|Firmicutes,24JTW@186801|Clostridia,36KXI@31979|Clostridiaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_456492_0	1304880.JAGB01000002_gene1661	1.467e-176	563.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia	186801|Clostridia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS04230	AICARFT_IMPCHas,MGS
DEZH2_k127_456492_1	588581.Cpap_0931	8.222e-24	102.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,3WGPD@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
DEZH2_k127_4581920_1	350688.Clos_2048	5.743e-82	278.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,36E9C@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
DEZH2_k127_4581920_2	1449050.JNLE01000003_gene1984	5.924e-59	220.0	COG2207@1|root,COG2207@2|Bacteria,1U23Q@1239|Firmicutes,25BMJ@186801|Clostridia,36WGY@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
DEZH2_k127_4581920_0	1408424.JHYI01000006_gene481	2.639e-172	557.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,4HAAG@91061|Bacilli,1ZPV2@1386|Bacillus	91061|Bacilli	G	Belongs to the glycosyl hydrolase 3 family	bglB	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
DEZH2_k127_4605952_0	1291050.JAGE01000001_gene2623	1.407e-230	723.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,3WGBI@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
DEZH2_k127_4624218_3	658655.HMPREF0988_02223	6.097e-80	274.0	COG1874@1|root,COG1874@2|Bacteria,1UZ5Q@1239|Firmicutes,24CFY@186801|Clostridia,27REH@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Glycosyl hydrolases family 35	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_35,Glyco_hydro_42
DEZH2_k127_4624218_4	97139.C824_03844	1.125e-56	207.0	COG2207@1|root,COG2207@2|Bacteria,1V4GS@1239|Firmicutes,24HHT@186801|Clostridia,36M0D@31979|Clostridiaceae	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
DEZH2_k127_4624218_1	1321782.HMPREF1986_01160	1.799e-108	356.0	COG1101@1|root,COG1101@2|Bacteria,1TPAN@1239|Firmicutes,247WW@186801|Clostridia,2PR9M@265975|Oribacterium	186801|Clostridia	S	ATPases associated with a variety of cellular activities	-	-	-	ko:K05833	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
DEZH2_k127_4624218_2	1123511.KB905850_gene3196	1.325e-96	324.0	COG4120@1|root,COG4120@2|Bacteria,1TPDJ@1239|Firmicutes,4H2HW@909932|Negativicutes	909932|Negativicutes	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	BPD_transp_2
DEZH2_k127_4624218_0	1120746.CCNL01000010_gene1175	1.492e-123	404.0	COG2984@1|root,COG2984@2|Bacteria,2NPCT@2323|unclassified Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	XK27_00670	-	-	ko:K01989,ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
DEZH2_k127_4645305_2	1392491.JIAE01000001_gene1816	1.349e-05	47.0	COG1533@1|root,COG1533@2|Bacteria,1TQA6@1239|Firmicutes,24A2T@186801|Clostridia,3WIAI@541000|Ruminococcaceae	186801|Clostridia	L	Domain of unknown function (DUF1848)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1848
DEZH2_k127_4645305_0	478749.BRYFOR_07296	1.355e-161	518.0	COG1373@1|root,COG1373@2|Bacteria,1TP7X@1239|Firmicutes,247ZX@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
DEZH2_k127_4645305_1	767817.Desgi_3510	5.687e-69	238.0	COG2110@1|root,COG2110@2|Bacteria,1TPCU@1239|Firmicutes,24ARG@186801|Clostridia,261T9@186807|Peptococcaceae	186801|Clostridia	S	PFAM Appr-1-p processing	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Macro
DEZH2_k127_4647926_0	203119.Cthe_1789	5.005e-296	931.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,3WGYI@541000|Ruminococcaceae	186801|Clostridia	O	Belongs to the ClpA ClpB family	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
DEZH2_k127_4647926_1	699246.HMPREF0868_0471	3.767e-92	313.0	COG3869@1|root,COG3869@2|Bacteria,1TPBA@1239|Firmicutes,247SS@186801|Clostridia,268PQ@186813|unclassified Clostridiales	186801|Clostridia	H	ATP:guanido phosphotransferase, C-terminal catalytic domain	mcsB	-	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
DEZH2_k127_4647926_5	1499968.TCA2_5591	1.099e-28	122.0	COG3880@1|root,COG3880@2|Bacteria,1V6YM@1239|Firmicutes,4HH4R@91061|Bacilli,26R52@186822|Paenibacillaceae	91061|Bacilli	S	protein with conserved CXXC pairs	mcsA	GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
DEZH2_k127_4647926_3	1121335.Clst_0262	1.027e-49	181.0	COG4463@1|root,COG4463@2|Bacteria,1VAXT@1239|Firmicutes,24JH3@186801|Clostridia,3WJYG@541000|Ruminococcaceae	186801|Clostridia	K	transcriptional repressor of class III stress genes	ctsR	-	-	ko:K03708	-	-	-	-	ko00000,ko03000	-	-	-	CtsR
DEZH2_k127_4647926_6	1116369.KB890024_gene1258	1.318e-11	77.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2U4TT@28211|Alphaproteobacteria,43NYG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
DEZH2_k127_4647926_2	1256908.HMPREF0373_02443	6.429e-85	296.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,25VQ1@186806|Eubacteriaceae	186801|Clostridia	H	Psort location Cytoplasmic, score	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
DEZH2_k127_4648054_1	1345695.CLSA_c21450	5.442e-77	269.0	COG3275@1|root,COG3437@1|root,COG3275@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD_5,PAS,PAS_4
DEZH2_k127_4648054_0	293826.Amet_3483	1.573e-120	407.0	COG2199@1|root,COG2206@1|root,COG3290@1|root,COG3829@1|root,COG2199@2|Bacteria,COG2206@2|Bacteria,COG3290@2|Bacteria,COG3829@2|Bacteria,1V6WM@1239|Firmicutes,24FPG@186801|Clostridia,36USB@31979|Clostridiaceae	186801|Clostridia	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HAMP,HD,HD_5,PAS,PAS_4,PAS_8,PAS_9,dCache_1
DEZH2_k127_4648054_3	1392491.JIAE01000001_gene930	1.253e-31	127.0	COG1695@1|root,COG1695@2|Bacteria,1VA8U@1239|Firmicutes,24NA9@186801|Clostridia,3WRW9@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
DEZH2_k127_4648054_5	702113.PP1Y_AT37114	5.921e-05	54.0	COG4709@1|root,COG4709@2|Bacteria,1RAQB@1224|Proteobacteria,2U62C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1700)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1700
DEZH2_k127_4648054_2	1123274.KB899407_gene122	6.901e-58	211.0	COG1028@1|root,COG1028@2|Bacteria	1123274.KB899407_gene122|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4648054_4	1123274.KB899407_gene121	8.091e-11	64.0	COG0300@1|root,COG0300@2|Bacteria,2J5I8@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
DEZH2_k127_4724988_2	1033740.CAEW01000039_gene254	6.904e-32	143.0	COG1305@1|root,COG1305@2|Bacteria,1TP8K@1239|Firmicutes,4HB2E@91061|Bacilli,26CTS@186818|Planococcaceae	91061|Bacilli	E	Transglutaminase/protease-like homologues	yebA	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
DEZH2_k127_4724988_1	994573.T472_0207930	4.194e-44	169.0	COG4430@1|root,COG4430@2|Bacteria,1V1VF@1239|Firmicutes,249ZH@186801|Clostridia,36I7W@31979|Clostridiaceae	186801|Clostridia	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
DEZH2_k127_4724988_0	994573.T472_0204380	7.031e-123	400.0	COG1657@1|root,COG1657@2|Bacteria,1TPY3@1239|Firmicutes,247MQ@186801|Clostridia,36FZF@31979|Clostridiaceae	186801|Clostridia	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_472971_1	340099.Teth39_1666	1.013e-31	125.0	COG3968@1|root,COG3968@2|Bacteria,1UHUF@1239|Firmicutes,2481B@186801|Clostridia,42F1I@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Glutamine synthetase, catalytic	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
DEZH2_k127_472971_0	1304880.JAGB01000003_gene1237	1.504e-136	443.0	COG0021@1|root,COG0021@2|Bacteria,1TPIB@1239|Firmicutes,25E6C@186801|Clostridia	186801|Clostridia	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt1	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
DEZH2_k127_4742180_0	1392491.JIAE01000001_gene2432	1.259e-69	247.0	COG1306@1|root,COG1306@2|Bacteria,1TQZV@1239|Firmicutes,24ADG@186801|Clostridia,3WJWX@541000|Ruminococcaceae	186801|Clostridia	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
DEZH2_k127_4755374_0	1121344.JHZO01000006_gene1840	6.648e-59	226.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,MerR_1,RDD
DEZH2_k127_4755374_1	485916.Dtox_4299	4.305e-35	139.0	COG4826@1|root,COG4826@2|Bacteria,1UYKX@1239|Firmicutes,24B76@186801|Clostridia,260NR@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
DEZH2_k127_481139_1	1120985.AUMI01000005_gene2482	8.37e-72	250.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4H2S5@909932|Negativicutes	909932|Negativicutes	L	hydrolase, TatD family	ycfH	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
DEZH2_k127_481139_2	1414720.CBYM010000012_gene2541	8.708e-72	258.0	COG1917@1|root,COG4977@1|root,COG1917@2|Bacteria,COG4977@2|Bacteria,1UJWB@1239|Firmicutes,25GMB@186801|Clostridia	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
DEZH2_k127_481139_0	1235792.C808_02560	4.777e-157	507.0	COG3507@1|root,COG3507@2|Bacteria,1UZHT@1239|Firmicutes,25GBD@186801|Clostridia	186801|Clostridia	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
DEZH2_k127_481139_4	1298920.KI911353_gene4686	6.718e-09	68.0	2DNHB@1|root,32XHV@2|Bacteria,1VAWM@1239|Firmicutes,25DB0@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_481139_3	1392491.JIAE01000001_gene2326	1.539e-10	62.0	2EGCS@1|root,33A4J@2|Bacteria,1VKIM@1239|Firmicutes,24WP6@186801|Clostridia,3WR8Q@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_481139_5	398512.JQKC01000023_gene3281	9.679e-09	57.0	2DPV4@1|root,333HA@2|Bacteria,1VH7Z@1239|Firmicutes,24SC2@186801|Clostridia,3WQ8C@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4822393_1	1392491.JIAE01000001_gene1354	3.053e-64	225.0	COG0326@1|root,COG0326@2|Bacteria,1TQEU@1239|Firmicutes,247ND@186801|Clostridia,3WGY6@541000|Ruminococcaceae	186801|Clostridia	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
DEZH2_k127_4822393_2	1392491.JIAE01000001_gene1353	1.598e-59	217.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,257WZ@186801|Clostridia,3WK6A@541000|Ruminococcaceae	186801|Clostridia	EH	Amino-transferase class IV	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_4
DEZH2_k127_4822393_0	1392491.JIAE01000001_gene1348	1.792e-108	354.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,3WGG9@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
DEZH2_k127_4876308_0	203119.Cthe_2593	1.892e-138	448.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,3WGA4@541000|Ruminococcaceae	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
DEZH2_k127_4876308_1	401526.TcarDRAFT_1424	2.09e-88	304.0	COG0009@1|root,COG0009@2|Bacteria,1TP1I@1239|Firmicutes,4H30C@909932|Negativicutes	909932|Negativicutes	H	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
DEZH2_k127_4876308_3	246194.CHY_2559	3.54e-28	119.0	COG0394@1|root,COG0394@2|Bacteria,1VA05@1239|Firmicutes,25CRM@186801|Clostridia,42GVA@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Protein-tyrosine phosphatase, low molecular weight	ywlE	-	3.1.3.48,3.9.1.2	ko:K01104,ko:K20201	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
DEZH2_k127_4876308_2	1291050.JAGE01000001_gene1718	2.219e-30	122.0	COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,24QZQ@186801|Clostridia,3WKNW@541000|Ruminococcaceae	186801|Clostridia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
DEZH2_k127_4876308_4	699246.HMPREF0868_1385	1.316e-08	55.0	COG0629@1|root,COG0629@2|Bacteria,1V3WT@1239|Firmicutes,24HF9@186801|Clostridia,268TK@186813|unclassified Clostridiales	186801|Clostridia	L	Single-strand binding protein family	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
DEZH2_k127_4895329_7	699246.HMPREF0868_1539	5.204e-29	117.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,268PJ@186813|unclassified Clostridiales	186801|Clostridia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
DEZH2_k127_4895329_0	1410638.JHXJ01000008_gene376	7.447e-92	305.0	COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,3WHH0@541000|Ruminococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
DEZH2_k127_4895329_6	699246.HMPREF0868_1541	9.641e-50	179.0	COG0051@1|root,COG0051@2|Bacteria,1V6C9@1239|Firmicutes,24JDC@186801|Clostridia,268VG@186813|unclassified Clostridiales	186801|Clostridia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
DEZH2_k127_4895329_5	658088.HMPREF0987_00391	6.874e-56	207.0	COG0726@1|root,COG0726@2|Bacteria,1TT1X@1239|Firmicutes,249PF@186801|Clostridia,27JGP@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Polysaccharide deacetylase	pdaA	-	-	ko:K01567	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
DEZH2_k127_4895329_2	1392491.JIAE01000001_gene515	6.036e-90	312.0	COG1281@1|root,COG1281@2|Bacteria,1TRCH@1239|Firmicutes,24940@186801|Clostridia,3WHW9@541000|Ruminococcaceae	186801|Clostridia	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
DEZH2_k127_4895329_3	755731.Clo1100_3666	2.926e-60	217.0	COG4976@1|root,COG4976@2|Bacteria,1UHZM@1239|Firmicutes,24A6U@186801|Clostridia,36UJF@31979|Clostridiaceae	186801|Clostridia	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
DEZH2_k127_4895329_1	699246.HMPREF0868_1553	4.856e-91	316.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,267R3@186813|unclassified Clostridiales	186801|Clostridia	M	tail specific protease	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
DEZH2_k127_4895329_4	1410638.JHXJ01000008_gene372	8.2e-58	211.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,3WGCB@541000|Ruminococcaceae	186801|Clostridia	D	Peptidase, M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
DEZH2_k127_4934565_6	871968.DESME_02605	8.685e-34	137.0	COG1246@1|root,COG1246@2|Bacteria,1V9D3@1239|Firmicutes,25DDN@186801|Clostridia	186801|Clostridia	E	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DEZH2_k127_4934565_5	994573.T472_0217805	1.964e-118	399.0	arCOG08054@1|root,2Z8AD@2|Bacteria,1TQ1J@1239|Firmicutes,2485U@186801|Clostridia,36EH0@31979|Clostridiaceae	186801|Clostridia	S	Carbohydrate-binding domain-containing protein Cthe_2159	-	GO:0001871,GO:0003674,GO:0005488,GO:0005509,GO:0030246,GO:0030247,GO:0030248,GO:0043167,GO:0043169,GO:0046872,GO:0048028,GO:2001062	-	-	-	-	-	-	-	-	-	-	Cthe_2159
DEZH2_k127_4934565_3	1304880.JAGB01000001_gene739	9.435e-129	427.0	COG1030@1|root,COG1030@2|Bacteria,1TR54@1239|Firmicutes,247N5@186801|Clostridia	186801|Clostridia	O	Membrane-bound serine protease (ClpP class)	yqeZ	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
DEZH2_k127_4934565_1	1499683.CCFF01000016_gene782	1.109e-166	538.0	COG0366@1|root,COG0366@2|Bacteria,1TSEA@1239|Firmicutes,248HJ@186801|Clostridia,36G5W@31979|Clostridiaceae	186801|Clostridia	G	Alpha-amylase domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459
DEZH2_k127_4934565_4	1499683.CCFF01000016_gene783	2.194e-128	415.0	COG3833@1|root,COG3833@2|Bacteria,1TRB7@1239|Firmicutes,248A7@186801|Clostridia,36HET@31979|Clostridiaceae	186801|Clostridia	G	Permease	-	-	-	ko:K15772	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
DEZH2_k127_4934565_0	1499683.CCFF01000016_gene784	9.899e-178	569.0	COG1175@1|root,COG1175@2|Bacteria,1TR2A@1239|Firmicutes,247MA@186801|Clostridia,36E1M@31979|Clostridiaceae	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
DEZH2_k127_4934565_2	1499683.CCFF01000016_gene785	4.861e-153	494.0	COG2182@1|root,COG2182@2|Bacteria,1VRPK@1239|Firmicutes,24Y63@186801|Clostridia,36W96@31979|Clostridiaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K15770	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	SBP_bac_8
DEZH2_k127_5005346_6	661087.HMPREF1008_00561	9.648e-74	255.0	COG0366@1|root,COG1640@1|root,COG0366@2|Bacteria,COG1640@2|Bacteria,2GJUT@201174|Actinobacteria,4CV47@84998|Coriobacteriia	84998|Coriobacteriia	G	Alpha amylase catalytic	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Alpha-amylase,Glyco_hydro_77
DEZH2_k127_5005346_2	1504822.CCNO01000011_gene214	4.81e-193	614.0	COG0297@1|root,COG0297@2|Bacteria,2NP1F@2323|unclassified Bacteria	2|Bacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
DEZH2_k127_5005346_5	1111121.HMPREF1247_0980	7.212e-108	361.0	COG0448@1|root,COG0448@2|Bacteria,2IT7F@201174|Actinobacteria,4CU7K@84998|Coriobacteriia	84998|Coriobacteriia	G	Glucose-1-phosphate adenylyltransferase, GlgD subunit	glgD	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
DEZH2_k127_5005346_4	1504822.CCNO01000011_gene216	2.465e-158	507.0	COG0448@1|root,COG0448@2|Bacteria,2NPBS@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
DEZH2_k127_5005346_0	661087.HMPREF1008_00557	0.0	1048.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria,4CU77@84998|Coriobacteriia	84998|Coriobacteriia	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
DEZH2_k127_5005346_1	679192.HMPREF9013_0192	3.134e-279	870.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,3VPHN@526524|Erysipelotrichia	526524|Erysipelotrichia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Alpha-amylase_C,CBM_48
DEZH2_k127_5005346_7	1121382.JQKG01000035_gene3871	1.772e-72	256.0	2DBC8@1|root,2Z8C9@2|Bacteria,1WKX1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5005346_3	699246.HMPREF0868_0391	1.599e-163	532.0	COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,26CRP@186813|unclassified Clostridiales	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
DEZH2_k127_5005346_8	97138.C820_00283	9.115e-54	192.0	COG0394@1|root,COG0394@2|Bacteria,1V6SG@1239|Firmicutes,24MMZ@186801|Clostridia,36J0M@31979|Clostridiaceae	186801|Clostridia	T	Low molecular weight phosphotyrosine protein phosphatase	yfkJ	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
DEZH2_k127_5005346_9	980584.AFPB01000162_gene2196	7.066e-05	46.0	COG0454@1|root,COG0456@2|Bacteria,4NFWE@976|Bacteroidetes,1HX0Z@117743|Flavobacteriia,406QC@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	K	GTP cyclohydrolase	yghO	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DEZH2_k127_5011988_3	293826.Amet_1334	4.187e-59	213.0	COG2081@1|root,COG2081@2|Bacteria,1TR7U@1239|Firmicutes,2497W@186801|Clostridia,36EA5@31979|Clostridiaceae	186801|Clostridia	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
DEZH2_k127_5011988_0	428125.CLOLEP_02582	2.015e-156	510.0	COG2509@1|root,COG2509@2|Bacteria,1TPBW@1239|Firmicutes,247TR@186801|Clostridia,3WGFA@541000|Ruminococcaceae	186801|Clostridia	S	FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	HI0933_like,NAD_binding_8,Pyr_redox_2
DEZH2_k127_5011988_5	1007096.BAGW01000014_gene1097	2.974e-34	154.0	COG0791@1|root,COG0791@2|Bacteria,1VUWD@1239|Firmicutes,24JFU@186801|Clostridia,2N8X1@216572|Oscillospiraceae	186801|Clostridia	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5011988_6	1410638.JHXJ01000002_gene1421	1.812e-23	118.0	COG5263@1|root,COG5263@2|Bacteria,1V0PX@1239|Firmicutes,25BA4@186801|Clostridia,3WS8S@541000|Ruminococcaceae	186801|Clostridia	D	Putative cell wall binding repeat	tcdB	-	-	ko:K11063	ko02024,map02024	-	-	-	ko00000,ko00001,ko02042	-	-	-	CW_binding_1,LRR_5,NLPC_P60,Peptidase_C80,TcdA_TcdB,TcdA_TcdB_pore,TcdB_N
DEZH2_k127_5011988_4	272558.10173911	2.039e-42	181.0	COG0860@1|root,COG3409@1|root,COG0860@2|Bacteria,COG3409@2|Bacteria,1UJ5S@1239|Firmicutes,4IT2Y@91061|Bacilli,1ZS8P@1386|Bacillus	91061|Bacilli	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
DEZH2_k127_5011988_2	411469.EUBHAL_02549	5.534e-74	260.0	COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,249SY@186801|Clostridia,25VM6@186806|Eubacteriaceae	186801|Clostridia	I	lipid kinase, YegS Rv2252 BmrU family	dagK	-	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
DEZH2_k127_5011988_1	411471.SUBVAR_07274	3.607e-154	502.0	COG3250@1|root,COG3250@2|Bacteria,1TQAM@1239|Firmicutes,248XS@186801|Clostridia,3WI0J@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
DEZH2_k127_5028628_1	1307761.L21SP2_1692	2.41e-95	318.0	COG2211@1|root,COG2211@2|Bacteria,2J6VC@203691|Spirochaetes	203691|Spirochaetes	G	TIGRFAM sugar (Glycoside-Pentoside-Hexuronide) transporter	-	-	-	ko:K11104,ko:K16209,ko:K16248	-	-	-	-	ko00000,ko02000	2.A.2,2.A.2.1,2.A.2.2	-	-	MFS_2
DEZH2_k127_5028628_0	357809.Cphy_1936	1.458e-148	478.0	COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,2489F@186801|Clostridia,21XH7@1506553|Lachnoclostridium	186801|Clostridia	G	Glycosyl hydrolase family 36 C-terminal domain	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
DEZH2_k127_5099737_6	1408813.AYMG01000018_gene5073	0.0003254	48.0	COG0477@1|root,COG2814@2|Bacteria,4NE09@976|Bacteroidetes,1IP67@117747|Sphingobacteriia	976|Bacteroidetes	EGP	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	araE	-	-	ko:K02100	-	-	-	-	ko00000,ko02000	2.A.1.1.2	-	-	Sugar_tr
DEZH2_k127_5099737_2	595460.RRSWK_01193	4.307e-120	392.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_5099737_1	545695.TREAZ_1805	1.232e-146	470.0	COG1082@1|root,COG1082@2|Bacteria,2J9B4@203691|Spirochaetes	203691|Spirochaetes	G	PFAM AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
DEZH2_k127_5099737_5	1499967.BAYZ01000159_gene488	1.166e-10	73.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
DEZH2_k127_5099737_3	1195236.CTER_0376	1.793e-68	245.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,3WJH2@541000|Ruminococcaceae	186801|Clostridia	P	Ribose xylose arabinose galactoside ABC-type transport systems permease components	-	-	-	ko:K02057,ko:K10440,ko:K10560	ko02010,map02010	M00212,M00220,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.9	-	-	BPD_transp_2
DEZH2_k127_5099737_0	1122963.AUHB01000001_gene695	2.097e-166	537.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC transporter	alsA	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
DEZH2_k127_5099737_4	545695.TREAZ_2900	1.461e-49	181.0	COG1482@1|root,COG1482@2|Bacteria	2|Bacteria	G	cell wall glycoprotein biosynthetic process	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
DEZH2_k127_5112946_1	1203606.HMPREF1526_00134	7e-62	229.0	COG0169@1|root,COG0703@1|root,COG0169@2|Bacteria,COG0703@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,36E3G@31979|Clostridiaceae	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI,Shikimate_DH,Shikimate_dh_N
DEZH2_k127_5112946_0	1511.CLOST_0861	3.365e-117	386.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia,25SRY@186804|Peptostreptococcaceae	186801|Clostridia	NU	Type II/IV secretion system protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
DEZH2_k127_5112946_6	1511.CLOST_0860	0.0001785	51.0	2C7ZS@1|root,300B5@2|Bacteria,1UF8Z@1239|Firmicutes,25K9P@186801|Clostridia,25UBE@186804|Peptostreptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5112946_5	864565.HMPREF0379_0176	1.698e-05	53.0	2BAJ8@1|root,323ZZ@2|Bacteria,1UF1R@1239|Firmicutes,25K2F@186801|Clostridia,25U7Q@186804|Peptostreptococcaceae	186801|Clostridia	S	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
DEZH2_k127_5112946_4	1256908.HMPREF0373_01807	9.662e-11	70.0	2E9V5@1|root,33410@2|Bacteria,1VEQY@1239|Firmicutes,24J21@186801|Clostridia,25XVQ@186806|Eubacteriaceae	186801|Clostridia	S	Domain of unknown function (DUF4860)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4860
DEZH2_k127_5112946_3	428125.CLOLEP_00423	5.292e-15	79.0	2E4EX@1|root,32ZA3@2|Bacteria,1VEQT@1239|Firmicutes,24QUI@186801|Clostridia,3WMR3@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5112946_2	497964.CfE428DRAFT_3562	2.713e-39	155.0	COG1459@1|root,COG1459@2|Bacteria,46S5B@74201|Verrucomicrobia	74201|Verrucomicrobia	U	PFAM type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
DEZH2_k127_5129455_1	697329.Rumal_0613	6.341e-57	207.0	COG0834@1|root,COG0834@2|Bacteria,1TT16@1239|Firmicutes,24CEZ@186801|Clostridia,3WIYH@541000|Ruminococcaceae	186801|Clostridia	ET	Belongs to the bacterial solute-binding protein 3 family	artP	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
DEZH2_k127_5129455_0	720554.Clocl_1320	3.846e-162	526.0	COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,3WHBB@541000|Ruminococcaceae	186801|Clostridia	J	phenylalanyl-tRNA synthetase (beta subunit)	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
DEZH2_k127_5130237_1	428125.CLOLEP_02037	6.831e-36	138.0	COG0461@1|root,COG0461@2|Bacteria,1V23H@1239|Firmicutes,24FTS@186801|Clostridia,3WIVV@541000|Ruminococcaceae	186801|Clostridia	F	Orotate phosphoribosyltransferase	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	-
DEZH2_k127_5130237_2	411459.RUMOBE_01120	1.532e-07	61.0	2EZM8@1|root,33SSD@2|Bacteria,1VRPR@1239|Firmicutes,24YKK@186801|Clostridia,3Y0RC@572511|Blautia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5130237_0	748727.CLJU_c03710	9.799e-146	467.0	COG2899@1|root,COG2899@2|Bacteria,1VYX2@1239|Firmicutes,24Z60@186801|Clostridia	1239|Firmicutes	S	Protein of unknown function (DUF475)	-	-	-	ko:K09799	-	-	-	-	ko00000	-	-	-	DUF475
DEZH2_k127_5154620_0	1392493.JIAB01000001_gene1044	1.454e-103	340.0	COG2221@1|root,COG4624@1|root,COG2221@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,25BE5@186801|Clostridia,27U0B@186928|unclassified Lachnospiraceae	186801|Clostridia	C	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_7,PAS,PAS_4
DEZH2_k127_5154620_1	926550.CLDAP_38560	1.678e-46	171.0	COG1764@1|root,COG1764@2|Bacteria,2G6W8@200795|Chloroflexi	200795|Chloroflexi	O	PFAM OsmC family protein	-	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
DEZH2_k127_5154620_2	1286171.EAL2_c08020	3.084e-44	163.0	COG3123@1|root,COG3123@2|Bacteria,1VBF3@1239|Firmicutes,24JI0@186801|Clostridia	186801|Clostridia	S	Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions	ppnP	-	2.4.2.1,2.4.2.2	ko:K09913	ko00230,ko00240,map00230,map00240	-	R01561,R01570,R01863,R01876,R02147,R02296,R02297	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	DUF1255
DEZH2_k127_5228936_1	589924.Ferp_2513	3.988e-31	130.0	COG2193@1|root,arCOG01094@2157|Archaea,2Y22S@28890|Euryarchaeota	28890|Euryarchaeota	P	Ferritin-like domain	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
DEZH2_k127_5228936_0	720554.Clocl_1241	1.956e-92	315.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,1V2ZP@1239|Firmicutes,24G58@186801|Clostridia,3WIKP@541000|Ruminococcaceae	186801|Clostridia	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF5050,PASTA,Pkinase,SH3_3
DEZH2_k127_5228936_2	1423815.BACR01000006_gene288	1.659e-05	57.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,3F4G6@33958|Lactobacillaceae	91061|Bacilli	KLT	serine threonine protein kinase	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
DEZH2_k127_5234601_0	1408254.T458_23765	7.457e-136	439.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli,26SVT@186822|Paenibacillaceae	91061|Bacilli	G	import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441,ko:K10562	ko02010,map02010	M00212,M00220	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.9	-	-	ABC_tran
DEZH2_k127_5234601_1	28444.JODQ01000001_gene2386	3.024e-72	255.0	COG1879@1|root,COG1879@2|Bacteria,2I8KH@201174|Actinobacteria,4EM9C@85012|Streptosporangiales	201174|Actinobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
DEZH2_k127_5234601_2	1122917.KB899661_gene1017	6.984e-60	233.0	COG2207@1|root,COG2207@2|Bacteria,1VUE3@1239|Firmicutes,4ISPH@91061|Bacilli,2775T@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
DEZH2_k127_5234601_3	502558.EGYY_26600	2.747e-50	188.0	28QIE@1|root,2ZD0E@2|Bacteria,2IHCK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5234601_4	1042156.CXIVA_05990	4.632e-36	140.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,36E3Q@31979|Clostridiaceae	186801|Clostridia	E	Dehydrogenase	-	-	1.1.1.1,1.1.1.14,1.1.1.284	ko:K00008,ko:K00121	ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	M00014	R00623,R00754,R00875,R01896,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00085,RC00087,RC00088,RC00099,RC00102,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
DEZH2_k127_5235766_4	1536769.P40081_27855	1.596e-09	60.0	COG1653@1|root,COG1653@2|Bacteria,1TPWV@1239|Firmicutes,4HEIR@91061|Bacilli,271EU@186822|Paenibacillaceae	91061|Bacilli	G	Domain of unknown function (DUF3502)	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	DUF3502
DEZH2_k127_5235766_1	658086.HMPREF0994_00824	8.561e-108	358.0	COG4209@1|root,COG4209@2|Bacteria,1TQFY@1239|Firmicutes,24923@186801|Clostridia,27INJ@186928|unclassified Lachnospiraceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
DEZH2_k127_5235766_2	1280680.AUJU01000008_gene157	1.171e-83	289.0	COG0395@1|root,COG0395@2|Bacteria,1TP1G@1239|Firmicutes,24BAS@186801|Clostridia,4C1Y6@830|Butyrivibrio	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
DEZH2_k127_5235766_0	658086.HMPREF0994_01179	1.017e-174	563.0	COG3507@1|root,COG3507@2|Bacteria,1TP5K@1239|Firmicutes,247R2@186801|Clostridia,27IEH@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Glycosyl hydrolases family 43	-	-	3.2.1.37,3.2.1.55	ko:K01198,ko:K01209	ko00520,ko01100,map00520,map01100	-	R01433,R01762	RC00467	ko00000,ko00001,ko01000	-	GH43,GH51	-	Glyco_hydro_43
DEZH2_k127_5235766_3	1280681.AUJZ01000004_gene2740	4.593e-15	76.0	COG2730@1|root,COG2730@2|Bacteria,1UQKQ@1239|Firmicutes,25BW2@186801|Clostridia	186801|Clostridia	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
DEZH2_k127_5247718_0	768486.EHR_12790	1.119e-217	687.0	COG1038@1|root,COG1038@2|Bacteria,1UHP9@1239|Firmicutes,4IS56@91061|Bacilli,4B0NN@81852|Enterococcaceae	91061|Bacilli	C	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second	pyc	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
DEZH2_k127_5247718_3	357809.Cphy_2327	6.264e-27	116.0	COG1607@1|root,COG1607@2|Bacteria,1V3S2@1239|Firmicutes,24JIT@186801|Clostridia,220Q7@1506553|Lachnoclostridium	186801|Clostridia	I	Thioesterase superfamily	yciA	-	-	-	-	-	-	-	-	-	-	-	4HBT
DEZH2_k127_5247718_2	1195236.CTER_2421	1.8e-37	143.0	COG0347@1|root,COG0347@2|Bacteria,1V9Z5@1239|Firmicutes,24MNA@186801|Clostridia,3WJYJ@541000|Ruminococcaceae	186801|Clostridia	K	Belongs to the P(II) protein family	glnB2	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
DEZH2_k127_5247718_1	663278.Ethha_2198	2.222e-71	244.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,3WGAK@541000|Ruminococcaceae	186801|Clostridia	U	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
DEZH2_k127_5265116_3	1408422.JHYF01000017_gene1872	1.191e-76	259.0	COG0702@1|root,COG0702@2|Bacteria,1UY7W@1239|Firmicutes,24CSQ@186801|Clostridia,36FXU@31979|Clostridiaceae	186801|Clostridia	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
DEZH2_k127_5265116_0	1304866.K413DRAFT_4566	2.248e-132	425.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,36DJ4@31979|Clostridiaceae	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
DEZH2_k127_5265116_2	552811.Dehly_1323	1.933e-79	273.0	COG0704@1|root,COG0704@2|Bacteria,2G6HD@200795|Chloroflexi,34D3P@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
DEZH2_k127_5265116_1	1298920.KI911353_gene1395	9.311e-108	355.0	COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia,2219W@1506553|Lachnoclostridium	186801|Clostridia	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
DEZH2_k127_5267246_1	931276.Cspa_c47530	2.885e-74	260.0	COG0655@1|root,COG0655@2|Bacteria,1UYDQ@1239|Firmicutes,24BAR@186801|Clostridia,36H9Z@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DEZH2_k127_5267246_2	1345695.CLSA_c22280	1.718e-27	120.0	COG1357@1|root,COG1357@2|Bacteria,1VAPB@1239|Firmicutes,24J9N@186801|Clostridia,36I04@31979|Clostridiaceae	186801|Clostridia	S	Pentapeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
DEZH2_k127_5267246_3	157072.XP_008868997.1	2.958e-07	60.0	2AE0J@1|root,2RYUP@2759|Eukaryota	2759|Eukaryota	S	Domain of unknown function (DUF4203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4203
DEZH2_k127_5267246_0	768706.Desor_2748	1.091e-119	389.0	COG0778@1|root,COG0778@2|Bacteria,1UB8S@1239|Firmicutes,249SD@186801|Clostridia,263KU@186807|Peptococcaceae	186801|Clostridia	C	Nitroreductase family	-	-	1.5.1.38	ko:K19285	ko00740,ko01100,map00740,map01100	-	R05706	RC00126	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
DEZH2_k127_5271819_0	537013.CLOSTMETH_00024	1.804e-185	591.0	COG1070@1|root,COG1070@2|Bacteria,1TP7Z@1239|Firmicutes,247ZU@186801|Clostridia,3WHQA@541000|Ruminococcaceae	186801|Clostridia	H	Carbohydrate kinase, FGGY family protein	rhaB	-	2.7.1.5,2.7.1.51	ko:K00848,ko:K00879	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014,R03241	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
DEZH2_k127_5271819_1	1121335.Clst_0622	1.087e-73	261.0	COG3347@1|root,COG3347@2|Bacteria,1UZ1Q@1239|Firmicutes,24B7Y@186801|Clostridia	186801|Clostridia	IQ	Class II aldolase adducin family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
DEZH2_k127_5271819_2	869213.JCM21142_2726	3.364e-12	66.0	COG4806@1|root,COG4806@2|Bacteria,4NHKW@976|Bacteroidetes	976|Bacteroidetes	G	Psort location Cytoplasmic, score 8.96	rhaA	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008740,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019324,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	5.3.1.14	ko:K01813	ko00051,ko01120,map00051,map01120	-	R02437	RC00434	ko00000,ko00001,ko01000	-	-	-	RhaA
DEZH2_k127_5271824_2	1121335.Clst_1016	3.017e-30	124.0	COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia,3WHJG@541000|Ruminococcaceae	186801|Clostridia	G	Alpha-L-rhamnosidase N-terminal domain protein	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
DEZH2_k127_5271824_0	1536774.H70357_08035	9.603e-73	257.0	COG1172@1|root,COG1172@2|Bacteria,1TRVC@1239|Firmicutes,4I7D1@91061|Bacilli,26WEU@186822|Paenibacillaceae	91061|Bacilli	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_5271824_1	1274374.CBLK010000059_gene369	5.051e-36	151.0	COG1609@1|root,COG1609@2|Bacteria,1UNWF@1239|Firmicutes,4IUSK@91061|Bacilli,26W12@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
DEZH2_k127_5271824_3	1235800.C819_03337	1.272e-19	92.0	COG1172@1|root,COG1172@2|Bacteria,1U0FI@1239|Firmicutes,24B5S@186801|Clostridia,27J2Q@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
DEZH2_k127_5283520_3	1007096.BAGW01000014_gene1082	2.74e-21	94.0	COG4974@1|root,COG4974@2|Bacteria,1V2WH@1239|Firmicutes,24GXU@186801|Clostridia,2N89Y@216572|Oscillospiraceae	186801|Clostridia	L	Plasmid pRiA4b ORF-3-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
DEZH2_k127_5283520_0	1094715.CM001373_gene1144	1.769e-94	317.0	COG0656@1|root,COG0656@2|Bacteria,1MWFS@1224|Proteobacteria,1RMX6@1236|Gammaproteobacteria,1JD8I@118969|Legionellales	118969|Legionellales	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
DEZH2_k127_5283520_2	1449343.JQLQ01000002_gene709	4.29e-56	211.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
DEZH2_k127_5283520_1	1461580.CCAS010000049_gene3556	6.608e-72	246.0	2C3KP@1|root,2Z802@2|Bacteria,1TQD1@1239|Firmicutes,4HBGA@91061|Bacilli,1ZC7G@1386|Bacillus	91061|Bacilli	S	Phage tail protein	yjhE	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5283520_4	1049564.TevJSym_bf00250	4.362e-14	79.0	COG2304@1|root,COG3509@1|root,COG4257@1|root,COG2304@2|Bacteria,COG3509@2|Bacteria,COG4257@2|Bacteria,1PDQV@1224|Proteobacteria,1RPGD@1236|Gammaproteobacteria,1J904@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	DUF5011,FG-GAP_2
DEZH2_k127_5300989_0	509191.AEDB02000108_gene1584	5.517e-180	571.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,3WHTD@541000|Ruminococcaceae	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
DEZH2_k127_5300989_4	1121335.Clst_1041	7.836e-31	125.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,3WJ9Y@541000|Ruminococcaceae	186801|Clostridia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
DEZH2_k127_5300989_2	588581.Cpap_1054	1.586e-50	192.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,3WGKS@541000|Ruminococcaceae	186801|Clostridia	S	domain protein	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
DEZH2_k127_5300989_3	443144.GM21_2978	5.964e-50	190.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,42MU5@68525|delta/epsilon subdivisions,2WKWY@28221|Deltaproteobacteria,43UI1@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C,TruB_C_2,TruB_N
DEZH2_k127_5300989_1	1121335.Clst_1044	4.513e-59	230.0	COG0196@1|root,COG0196@2|Bacteria,1TPKS@1239|Firmicutes,2484A@186801|Clostridia,3WJFU@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
DEZH2_k127_5304070_3	1392491.JIAE01000001_gene492	1.322e-25	108.0	2EBDP@1|root,335EB@2|Bacteria,1VGYB@1239|Firmicutes,2584G@186801|Clostridia,3WKSN@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5304070_1	720554.Clocl_0329	2.163e-79	274.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,3WHY1@541000|Ruminococcaceae	186801|Clostridia	S	MazG family	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
DEZH2_k127_5304070_4	1235790.C805_03025	1.448e-25	109.0	COG1188@1|root,COG1188@2|Bacteria,1VEI5@1239|Firmicutes,24QNF@186801|Clostridia,25XAD@186806|Eubacteriaceae	186801|Clostridia	J	S4 domain protein	hslR	-	-	-	-	-	-	-	-	-	-	-	S4
DEZH2_k127_5304070_5	1209989.TepiRe1_0192	2.835e-05	50.0	COG2919@1|root,COG2919@2|Bacteria,1VGDD@1239|Firmicutes,25JJJ@186801|Clostridia,42HFW@68295|Thermoanaerobacterales	186801|Clostridia	D	Septum formation initiator	-	-	-	ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
DEZH2_k127_5304070_0	935948.KE386495_gene1092	3.58e-125	409.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,42FC3@68295|Thermoanaerobacterales	186801|Clostridia	P	Belongs to the ABC transporter superfamily	oppF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
DEZH2_k127_5304070_2	1128398.Curi_c03180	3.561e-32	126.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,2689V@186813|unclassified Clostridiales	186801|Clostridia	EP	Oligopeptide/dipeptide transporter, C-terminal region	oppD	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
DEZH2_k127_5337035_1	1122915.AUGY01000025_gene6851	1.021e-123	400.0	COG1125@1|root,COG1125@2|Bacteria,1TPV8@1239|Firmicutes,4H9SI@91061|Bacilli,26SM2@186822|Paenibacillaceae	91061|Bacilli	E	Glycine betaine	proV	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
DEZH2_k127_5337035_2	180332.JTGN01000011_gene493	2.839e-73	253.0	COG1174@1|root,COG1174@2|Bacteria,1V24D@1239|Firmicutes,24H6D@186801|Clostridia	186801|Clostridia	P	inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
DEZH2_k127_5337035_0	1174504.AJTN02000233_gene2569	2.234e-129	421.0	COG0604@1|root,COG0604@2|Bacteria,1TQ0M@1239|Firmicutes,4HA8M@91061|Bacilli,1ZD7C@1386|Bacillus	91061|Bacilli	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
DEZH2_k127_5337035_3	1282887.AUJG01000009_gene1460	1.003e-40	153.0	COG1733@1|root,COG1733@2|Bacteria,1VA9M@1239|Firmicutes,24JJB@186801|Clostridia	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
DEZH2_k127_5342191_1	742735.HMPREF9467_05229	1.303e-05	50.0	COG1733@1|root,COG1733@2|Bacteria,1V8IJ@1239|Firmicutes,24KW5@186801|Clostridia	186801|Clostridia	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
DEZH2_k127_5342191_0	1158607.UAU_00923	1.264e-119	400.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,4HTTR@91061|Bacilli,4B4J7@81852|Enterococcaceae	91061|Bacilli	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
DEZH2_k127_534957_4	1297617.JPJD01000007_gene86	4.751e-52	186.0	COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,247Q8@186801|Clostridia,267Y9@186813|unclassified Clostridiales	186801|Clostridia	EF	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
DEZH2_k127_534957_1	1392491.JIAE01000001_gene93	4.743e-109	369.0	COG0771@1|root,COG0771@2|Bacteria,1UHPI@1239|Firmicutes,25E9J@186801|Clostridia,3WSID@541000|Ruminococcaceae	186801|Clostridia	M	Mur ligase middle domain	murE2	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	DUF1727,Mur_ligase_M
DEZH2_k127_534957_3	394503.Ccel_2070	1.325e-83	286.0	COG3442@1|root,COG3442@2|Bacteria,1U7I9@1239|Firmicutes,24A80@186801|Clostridia,36DUC@31979|Clostridiaceae	186801|Clostridia	S	glutamine amidotransferase	-	-	-	ko:K07009	-	-	-	-	ko00000	-	-	-	GATase_3
DEZH2_k127_534957_0	1280698.AUJS01000011_gene449	2.652e-109	360.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,27UVB@189330|Dorea	186801|Clostridia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
DEZH2_k127_534957_2	552398.HMPREF0866_01983	2.647e-85	286.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,24969@186801|Clostridia,3WGFU@541000|Ruminococcaceae	186801|Clostridia	H	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DEZH2_k127_5354516_3	350688.Clos_1437	4.852e-34	139.0	COG1564@1|root,COG1564@2|Bacteria,1VA0W@1239|Firmicutes,24NG6@186801|Clostridia,36J5Q@31979|Clostridiaceae	186801|Clostridia	H	thiamine pyrophosphokinase	thiN	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
DEZH2_k127_5354516_1	699246.HMPREF0868_1147	3.261e-70	246.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,268XI@186813|unclassified Clostridiales	186801|Clostridia	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
DEZH2_k127_5354516_2	1392491.JIAE01000001_gene1056	2.544e-66	236.0	COG1162@1|root,COG1162@2|Bacteria,1TPSQ@1239|Firmicutes,248R5@186801|Clostridia,3WGGY@541000|Ruminococcaceae	186801|Clostridia	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
DEZH2_k127_5354516_0	1410638.JHXJ01000010_gene117	2.917e-117	396.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3WGK8@541000|Ruminococcaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
DEZH2_k127_5368234_2	349161.Dred_1750	1.141e-28	126.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1TPYV@1239|Firmicutes,248XC@186801|Clostridia,267C9@186807|Peptococcaceae	186801|Clostridia	H	Homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
DEZH2_k127_5368234_4	441769.ABFU01000130_gene2342	1.245e-09	69.0	2EG8N@1|root,33A0G@2|Bacteria,1VMHK@1239|Firmicutes,4HSIH@91061|Bacilli,1ZJWT@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5368234_1	1380394.JADL01000003_gene4756	3.123e-38	156.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria,2JUHF@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
DEZH2_k127_5368234_0	398512.JQKC01000010_gene102	1.023e-42	157.0	COG0187@1|root,COG0187@2|Bacteria,1TQ6U@1239|Firmicutes,249NI@186801|Clostridia,3WH8Y@541000|Ruminococcaceae	186801|Clostridia	L	DNA topoisomerase	-	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
DEZH2_k127_5368234_3	1160721.RBI_II00266	6.028e-15	74.0	COG0187@1|root,COG0187@2|Bacteria,1TQ6U@1239|Firmicutes,249NI@186801|Clostridia,3WH8Y@541000|Ruminococcaceae	186801|Clostridia	L	DNA topoisomerase	-	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
DEZH2_k127_5374509_1	696369.KI912183_gene2743	1.585e-179	571.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,260N1@186807|Peptococcaceae	186801|Clostridia	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
DEZH2_k127_5374509_0	509191.AEDB02000035_gene2193	3.589e-227	712.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,2490X@186801|Clostridia,3WGBX@541000|Ruminococcaceae	186801|Clostridia	C	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
DEZH2_k127_5374509_2	931276.Cspa_c44330	7.041e-80	268.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,36DYK@31979|Clostridiaceae	186801|Clostridia	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
DEZH2_k127_5383098_2	357809.Cphy_0666	1.247e-100	338.0	COG3250@1|root,COG3250@2|Bacteria,1W77V@1239|Firmicutes,25J0P@186801|Clostridia,222YU@1506553|Lachnoclostridium	186801|Clostridia	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
DEZH2_k127_5383098_3	658655.HMPREF0988_02231	1.531e-86	309.0	COG2508@1|root,COG2508@2|Bacteria,1TRRH@1239|Firmicutes,24C6R@186801|Clostridia,27Q7Y@186928|unclassified Lachnospiraceae	186801|Clostridia	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
DEZH2_k127_5383098_1	931276.Cspa_c47530	1.39e-105	351.0	COG0655@1|root,COG0655@2|Bacteria,1UYDQ@1239|Firmicutes,24BAR@186801|Clostridia,36H9Z@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DEZH2_k127_5383098_0	931276.Cspa_c47480	1.514e-188	600.0	COG1053@1|root,COG1053@2|Bacteria,1TT1Q@1239|Firmicutes,249N4@186801|Clostridia,36FZX@31979|Clostridiaceae	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
DEZH2_k127_5409023_2	720554.Clocl_1103	7.416e-34	131.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,3WGSI@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
DEZH2_k127_5409023_1	871963.Desdi_1818	5.463e-93	310.0	COG0288@1|root,COG0288@2|Bacteria,1V1YB@1239|Firmicutes,24GMG@186801|Clostridia,261GG@186807|Peptococcaceae	186801|Clostridia	P	Reversible hydration of carbon dioxide	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
DEZH2_k127_5409023_0	929506.CbC4_1964	1.384e-168	541.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,2486F@186801|Clostridia,36F8B@31979|Clostridiaceae	186801|Clostridia	O	Negative regulator of genetic competence clpC mecB	-	-	-	ko:K03697	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small
DEZH2_k127_5455199_4	699246.HMPREF0868_0620	7.511e-126	416.0	COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,267KU@186813|unclassified Clostridiales	186801|Clostridia	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	pgcA	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
DEZH2_k127_5455199_0	720554.Clocl_2233	0.0	1283.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,3WGNQ@541000|Ruminococcaceae	186801|Clostridia	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
DEZH2_k127_5455199_3	1392491.JIAE01000001_gene2359	4.312e-136	440.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia,3WH67@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
DEZH2_k127_5455199_5	699246.HMPREF0868_1132	2.066e-50	186.0	COG0558@1|root,COG0558@2|Bacteria,1V35A@1239|Firmicutes,24IIY@186801|Clostridia,269CP@186813|unclassified Clostridiales	186801|Clostridia	I	CDP-alcohol phosphatidyltransferase	pgsA2	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
DEZH2_k127_5455199_1	509191.AEDB02000108_gene1615	2.909e-207	670.0	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia,3WGD7@541000|Ruminococcaceae	186801|Clostridia	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
DEZH2_k127_5455199_2	203119.Cthe_1292	1.072e-140	455.0	COG3635@1|root,COG3635@2|Bacteria,1TQ5S@1239|Firmicutes,248U6@186801|Clostridia,3WH2J@541000|Ruminococcaceae	186801|Clostridia	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
DEZH2_k127_5483872_1	1122915.AUGY01000001_gene7026	1.453e-64	228.0	COG0134@1|root,COG0134@2|Bacteria,1TR94@1239|Firmicutes,4HDZQ@91061|Bacilli,26QYK@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
DEZH2_k127_5483872_0	1069080.KB913028_gene1787	5.901e-95	322.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,4H1UK@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
DEZH2_k127_5491679_0	203119.Cthe_1869	1.502e-128	417.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,3WG9U@541000|Ruminococcaceae	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.6,2.1.3.9	ko:K00611,ko:K09065,ko:K13252	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12430	OTCace,OTCace_N
DEZH2_k127_5491679_1	246194.CHY_2262	1.202e-92	313.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,42F28@68295|Thermoanaerobacterales	186801|Clostridia	E	TIGRFAM acetylornithine and succinylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.13,2.6.1.17	ko:K00819,ko:K00821	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00667,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DEZH2_k127_550064_2	1414720.CBYM010000008_gene1030	3.228e-25	108.0	COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,24MQ3@186801|Clostridia,36KIR@31979|Clostridiaceae	186801|Clostridia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
DEZH2_k127_550064_0	398512.JQKC01000011_gene338	1.221e-125	414.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia,3WGCP@541000|Ruminococcaceae	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
DEZH2_k127_550064_3	1195236.CTER_2142	6.248e-13	72.0	COG1722@1|root,COG1722@2|Bacteria,1VK9I@1239|Firmicutes,24UH5@186801|Clostridia	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
DEZH2_k127_550064_1	203119.Cthe_0831	6.272e-55	199.0	COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,248DE@186801|Clostridia,3WINP@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iHN637.CLJU_RS05465	polyprenyl_synt
DEZH2_k127_5509737_1	1265505.ATUG01000002_gene2019	4.965e-69	238.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,42N3J@68525|delta/epsilon subdivisions,2WJ19@28221|Deltaproteobacteria,2MHRN@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
DEZH2_k127_5509737_0	270374.MELB17_22520	3.599e-217	681.0	COG5433@1|root,COG5433@2|Bacteria,1MY25@1224|Proteobacteria,1RMRM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
DEZH2_k127_5518484_0	1195236.CTER_0649	2.371e-233	735.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,3WH1A@541000|Ruminococcaceae	186801|Clostridia	G	Pyruvate kinase	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
DEZH2_k127_5518484_1	397288.C806_04085	2.613e-40	154.0	2E269@1|root,32XCU@2|Bacteria,1VBFU@1239|Firmicutes,24JDH@186801|Clostridia,27S1S@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Antitoxin of toxin-antitoxin, RelE / RelB, TA system	-	-	-	-	-	-	-	-	-	-	-	-	PHD_like
DEZH2_k127_5518484_2	411473.RUMCAL_01149	1.575e-28	117.0	COG2026@1|root,COG2026@2|Bacteria,1VFJM@1239|Firmicutes,24RGY@186801|Clostridia,3WPZD@541000|Ruminococcaceae	186801|Clostridia	DJ	Toxin-antitoxin system, toxin component, RelE family	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
DEZH2_k127_5518484_3	97139.C824_02961	3.567e-22	99.0	2DT2V@1|root,33IFX@2|Bacteria,1VJD5@1239|Firmicutes	1239|Firmicutes	S	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
DEZH2_k127_555255_2	1298920.KI911353_gene4455	8.774e-06	55.0	COG2199@1|root,COG3706@2|Bacteria,1UZ4B@1239|Firmicutes,249PH@186801|Clostridia,221XK@1506553|Lachnoclostridium	186801|Clostridia	T	diguanylate cyclase	-	-	2.7.7.65	ko:K18968	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko02000	9.B.34.1.2	-	-	GGDEF
DEZH2_k127_555255_0	868595.Desca_1282	4.848e-99	338.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,25ZXR@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
DEZH2_k127_555255_1	742735.HMPREF9467_00612	1.489e-42	164.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,21XFP@1506553|Lachnoclostridium	186801|Clostridia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
DEZH2_k127_5586857_1	387344.LVIS_1945	6.98e-35	136.0	COG1194@1|root,COG1194@2|Bacteria,1TPUT@1239|Firmicutes,4H9UM@91061|Bacilli,3FCD0@33958|Lactobacillaceae	91061|Bacilli	L	A G-specific adenine glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
DEZH2_k127_5586857_2	1195236.CTER_5541	1.551e-22	108.0	29WK4@1|root,30I6K@2|Bacteria,1UUY7@1239|Firmicutes,24UGQ@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5586857_0	1094508.Tsac_1318	3.058e-100	331.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,42F5Y@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DEZH2_k127_5619959_0	1123288.SOV_1c08810	4.761e-143	474.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,4H2RV@909932|Negativicutes	1239|Firmicutes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	-	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SecA_DEAD,SecA_PP_bind,SecA_SW
DEZH2_k127_5619959_1	643648.Slip_1140	2.37e-88	314.0	COG1835@1|root,COG1835@2|Bacteria,1V0J2@1239|Firmicutes,247YD@186801|Clostridia,42KQZ@68298|Syntrophomonadaceae	186801|Clostridia	I	Domain of unknown function (DUF4153)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4153
DEZH2_k127_5619959_4	1007096.BAGW01000009_gene2134	5.729e-41	160.0	COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,24AHX@186801|Clostridia,2N78J@216572|Oscillospiraceae	186801|Clostridia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
DEZH2_k127_5619959_3	1392491.JIAE01000001_gene405	3.071e-46	178.0	COG1876@1|root,COG1876@2|Bacteria,1V1F7@1239|Firmicutes,24E6R@186801|Clostridia,3WRN7@541000|Ruminococcaceae	186801|Clostridia	M	D-alanyl-D-alanine carboxypeptidase	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	DUF348,G5,VanY
DEZH2_k127_5619959_2	1487921.DP68_16830	2.553e-49	185.0	COG0664@1|root,COG0664@2|Bacteria,1V2AH@1239|Firmicutes,24H46@186801|Clostridia,36IIT@31979|Clostridiaceae	186801|Clostridia	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
DEZH2_k127_5623579_2	1195236.CTER_0562	2.959e-17	84.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,3WI2J@541000|Ruminococcaceae	186801|Clostridia	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
DEZH2_k127_5623579_1	573370.DMR_23210	1.469e-19	96.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,42U47@68525|delta/epsilon subdivisions,2WQXE@28221|Deltaproteobacteria,2MGGY@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
DEZH2_k127_5623579_0	273068.TTE0940	5.18e-45	172.0	COG1234@1|root,COG1234@2|Bacteria,1V1TF@1239|Firmicutes,25CI5@186801|Clostridia,42FQ4@68295|Thermoanaerobacterales	186801|Clostridia	S	beta-lactamase domain protein	ElaC	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
DEZH2_k127_5667763_2	545695.TREAZ_2097	1.528e-23	104.0	28M3X@1|root,2ZAHZ@2|Bacteria,2JB7I@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5667763_0	1469948.JPNB01000001_gene1226	0.0	1124.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,36DJE@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
DEZH2_k127_5667763_1	290402.Cbei_3052	1.541e-32	128.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36EQ3@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
DEZH2_k127_5673248_1	1392491.JIAE01000001_gene2539	1.931e-71	248.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,3WHR4@541000|Ruminococcaceae	186801|Clostridia	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
DEZH2_k127_5673248_0	1392491.JIAE01000001_gene2538	3.38e-113	381.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia,3WGHG@541000|Ruminococcaceae	186801|Clostridia	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
DEZH2_k127_5673248_2	509191.AEDB02000035_gene2210	9.863e-64	223.0	COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,3WGGQ@541000|Ruminococcaceae	186801|Clostridia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
DEZH2_k127_5705957_3	37919.EP51_22690	1.3e-22	102.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4FXKH@85025|Nocardiaceae	201174|Actinobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
DEZH2_k127_5705957_0	411468.CLOSCI_02753	3.457e-172	546.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,21YY1@1506553|Lachnoclostridium	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_21,Fer4_6,Fer4_7
DEZH2_k127_5705957_1	1121335.Clst_0450	3.665e-109	359.0	COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,248FK@186801|Clostridia,3WHB2@541000|Ruminococcaceae	186801|Clostridia	S	Aldo keto reductases, related to diketogulonate reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
DEZH2_k127_5705957_2	931626.Awo_c11770	1.015e-48	185.0	COG0407@1|root,COG0407@2|Bacteria,1W73C@1239|Firmicutes,2502K@186801|Clostridia,25YP1@186806|Eubacteriaceae	931626.Awo_c11770|-	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5734272_3	1320556.AVBP01000015_gene913	5.99e-09	60.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,43KDC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
DEZH2_k127_5734272_0	1121116.KB894768_gene2054	4.988e-37	144.0	COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2VSCN@28216|Betaproteobacteria,4AECI@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1178)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1178
DEZH2_k127_5734272_1	381666.H16_A2546	3.022e-21	94.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2VQI2@28216|Betaproteobacteria,1K0ZJ@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
DEZH2_k127_5737248_4	33035.JPJF01000049_gene630	2.731e-24	102.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,24XW6@186801|Clostridia,3XYRM@572511|Blautia	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_5737248_2	33035.JPJF01000049_gene628	2.128e-50	183.0	COG1082@1|root,COG1082@2|Bacteria,1V9CF@1239|Firmicutes,24K6D@186801|Clostridia	186801|Clostridia	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5737248_1	33035.JPJF01000049_gene629	3.971e-151	483.0	COG1082@1|root,COG1082@2|Bacteria,1TP32@1239|Firmicutes,24DX9@186801|Clostridia	186801|Clostridia	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_5737248_0	97139.C824_03951	4.544e-288	893.0	COG2936@1|root,COG2936@2|Bacteria,1TT0H@1239|Firmicutes,248PY@186801|Clostridia,36KCX@31979|Clostridiaceae	186801|Clostridia	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
DEZH2_k127_5737248_3	706587.Desti_3215	9.764e-28	117.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,42QW0@68525|delta/epsilon subdivisions,2WMZW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
DEZH2_k127_5764652_1	663278.Ethha_0056	4.595e-98	333.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,3WGNK@541000|Ruminococcaceae	186801|Clostridia	V	Efflux ABC transporter, permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DEZH2_k127_5764652_2	180332.JTGN01000007_gene3514	1.638e-86	294.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia	186801|Clostridia	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_5764652_3	35754.JNYJ01000013_gene1041	2.469e-15	89.0	COG0845@1|root,COG0845@2|Bacteria,2H154@201174|Actinobacteria,4DB31@85008|Micromonosporales	201174|Actinobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
DEZH2_k127_5764652_0	44251.PDUR_14655	1.398e-117	388.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,4HB4P@91061|Bacilli,26SCI@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
DEZH2_k127_5813542_2	1333856.L686_11430	5.242e-19	89.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1RYEF@1236|Gammaproteobacteria,1Z0D6@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	Bacteriophytochrome (Light-regulated signal transduction histidine kinase)	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_2,PHY
DEZH2_k127_5813542_0	269799.Gmet_0713	7.126e-94	337.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,MASE3,PAS_4,PAS_9,Response_reg
DEZH2_k127_5813542_1	555779.Dthio_PD3577	1.934e-30	124.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,43CDX@68525|delta/epsilon subdivisions,2X7PU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K02485	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg
DEZH2_k127_5813542_3	1209989.TepiRe1_2780	0.0005261	46.0	COG1917@1|root,COG1917@2|Bacteria,1V723@1239|Firmicutes,24K1V@186801|Clostridia	186801|Clostridia	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
DEZH2_k127_5833451_0	1122915.AUGY01000054_gene68	3.864e-146	482.0	COG2972@1|root,COG2972@2|Bacteria,1U6WN@1239|Firmicutes,4HASD@91061|Bacilli,274BU@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
DEZH2_k127_5833451_3	1122915.AUGY01000054_gene69	3.52e-58	208.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UCUQ@1239|Firmicutes,4HC5Q@91061|Bacilli,26QMW@186822|Paenibacillaceae	91061|Bacilli	T	PFAM response regulator receiver	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
DEZH2_k127_5833451_2	1122919.KB905584_gene3898	1.276e-72	256.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UCUQ@1239|Firmicutes,4HC5Q@91061|Bacilli,26QMW@186822|Paenibacillaceae	91061|Bacilli	T	PFAM response regulator receiver	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
DEZH2_k127_5833451_1	1122915.AUGY01000054_gene70	1.239e-139	461.0	COG1653@1|root,COG1653@2|Bacteria,1TPWV@1239|Firmicutes,4HEIR@91061|Bacilli,275IK@186822|Paenibacillaceae	91061|Bacilli	G	Extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	DUF3502,SBP_bac_1,SBP_bac_8
DEZH2_k127_5840771_1	585394.RHOM_09405	2.382e-31	123.0	COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,248T1@186801|Clostridia	186801|Clostridia	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
DEZH2_k127_5840771_0	1408422.JHYF01000013_gene591	0.0	1222.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,36FQY@31979|Clostridiaceae	186801|Clostridia	C	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
DEZH2_k127_5885850_1	485916.Dtox_4299	5.451e-115	377.0	COG4826@1|root,COG4826@2|Bacteria,1UYKX@1239|Firmicutes,24B76@186801|Clostridia,260NR@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
DEZH2_k127_5885850_6	1151292.QEW_2079	0.0001884	47.0	2ER3F@1|root,33IP2@2|Bacteria,1VMA9@1239|Firmicutes,24TRX@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
DEZH2_k127_5885850_4	1197706.AKKK01000006_gene1206	1.101e-09	64.0	COG3070@1|root,COG3070@2|Bacteria,2IRAD@201174|Actinobacteria	201174|Actinobacteria	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
DEZH2_k127_5885850_3	573061.Clocel_2927	2.262e-13	76.0	2BA7T@1|root,323MW@2|Bacteria,1UEZ6@1239|Firmicutes,24WYG@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5885850_2	1120944.JONS01000012_gene830	7.681e-98	329.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,4D44C@85005|Actinomycetales	201174|Actinobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
DEZH2_k127_5885850_5	273677.BW34_01114	5.356e-07	55.0	2E3DE@1|root,32YCK@2|Bacteria,2GRH4@201174|Actinobacteria,4FPZN@85023|Microbacteriaceae	201174|Actinobacteria	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
DEZH2_k127_5885850_0	931276.Cspa_c47390	9.831e-256	799.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,36EFE@31979|Clostridiaceae	186801|Clostridia	C	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
DEZH2_k127_5895466_1	509191.AEDB02000067_gene814	3.803e-36	139.0	COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia,3WH6T@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
DEZH2_k127_5895466_2	679935.Alfi_2313	9.725e-22	99.0	COG0526@1|root,COG0526@2|Bacteria,4NWU4@976|Bacteroidetes,2FT81@200643|Bacteroidia	976|Bacteroidetes	CO	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin,Thioredoxin_3
DEZH2_k127_5895466_0	913865.DOT_0372	2.044e-65	237.0	COG1408@1|root,COG1408@2|Bacteria,1TS43@1239|Firmicutes,248XA@186801|Clostridia,2600B@186807|Peptococcaceae	186801|Clostridia	S	PFAM Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
DEZH2_k127_5943608_2	1392491.JIAE01000001_gene1564	4.535e-14	75.0	COG1939@1|root,COG1939@2|Bacteria,1VA5V@1239|Firmicutes,24MR1@186801|Clostridia,3WJN8@541000|Ruminococcaceae	186801|Clostridia	J	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)	mrnC	-	-	ko:K11145	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Ribonuclease_3
DEZH2_k127_5943608_0	699246.HMPREF0868_0743	3.683e-180	576.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,2684B@186813|unclassified Clostridiales	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
DEZH2_k127_5943608_1	720554.Clocl_3981	1.298e-82	280.0	COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,249SF@186801|Clostridia,3WHD9@541000|Ruminococcaceae	186801|Clostridia	E	serine O-acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
DEZH2_k127_5948802_0	1408473.JHXO01000001_gene2487	3.442e-145	468.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,2FQ0Q@200643|Bacteroidia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
DEZH2_k127_5948802_1	1408473.JHXO01000011_gene3016	3.341e-143	463.0	COG0285@1|root,COG0285@2|Bacteria,4NES8@976|Bacteroidetes,2FNFB@200643|Bacteroidia	976|Bacteroidetes	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
DEZH2_k127_5957833_0	935837.JAEK01000021_gene676	5.784e-152	490.0	COG3507@1|root,COG3507@2|Bacteria,1TP5K@1239|Firmicutes,4HCT0@91061|Bacilli,1ZCKY@1386|Bacillus	91061|Bacilli	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37,3.2.1.55	ko:K01198,ko:K01209	ko00520,ko01100,map00520,map01100	-	R01433,R01762	RC00467	ko00000,ko00001,ko01000	-	GH43,GH51	-	Glyco_hydro_43
DEZH2_k127_5957833_1	1122918.KB907260_gene1928	1.852e-38	151.0	COG3250@1|root,COG3250@2|Bacteria,1TS9P@1239|Firmicutes,4HB8A@91061|Bacilli,26RTY@186822|Paenibacillaceae	91061|Bacilli	G	Glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
DEZH2_k127_5959523_1	877414.ATWA01000035_gene1254	1.003e-28	118.0	COG2755@1|root,COG2755@2|Bacteria,1VJFT@1239|Firmicutes	1239|Firmicutes	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
DEZH2_k127_5959523_0	1121335.Clst_1016	6.534e-152	492.0	COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia,3WHJG@541000|Ruminococcaceae	186801|Clostridia	G	Alpha-L-rhamnosidase N-terminal domain protein	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
DEZH2_k127_5968708_2	610130.Closa_1316	5.886e-13	72.0	COG0144@1|root,COG3270@1|root,COG0144@2|Bacteria,COG3270@2|Bacteria,1TPGQ@1239|Firmicutes,247N0@186801|Clostridia,21XVU@1506553|Lachnoclostridium	186801|Clostridia	J	RNA-binding PUA-like domain of methyltransferase RsmF	-	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI
DEZH2_k127_5968708_0	1410638.JHXJ01000007_gene1077	5.159e-157	512.0	COG1164@1|root,COG1164@2|Bacteria,1TPV4@1239|Firmicutes,2495D@186801|Clostridia,3WHMS@541000|Ruminococcaceae	186801|Clostridia	E	Peptidase family M3	pz-A	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3
DEZH2_k127_5968708_1	1410638.JHXJ01000007_gene1076	4.005e-18	86.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,3WHS0@541000|Ruminococcaceae	186801|Clostridia	J	Arginyl tRNA synthetase N terminal dom	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
DEZH2_k127_5968708_3	1392491.JIAE01000001_gene1185	7.392e-12	66.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,3WHS0@541000|Ruminococcaceae	186801|Clostridia	J	Arginyl tRNA synthetase N terminal dom	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
DEZH2_k127_6000772_0	935845.JADQ01000016_gene3623	1.37e-48	186.0	COG3173@1|root,COG3173@2|Bacteria,1U4B2@1239|Firmicutes,4HG90@91061|Bacilli,26WJ7@186822|Paenibacillaceae	91061|Bacilli	S	Phosphotransferase enzyme family	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	APH
DEZH2_k127_6008075_0	699246.HMPREF0868_1434	9.963e-129	424.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,267VA@186813|unclassified Clostridiales	186801|Clostridia	C	V-type ATPase 116kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
DEZH2_k127_6008075_2	555088.DealDRAFT_1683	1.289e-45	170.0	COG0636@1|root,COG0636@2|Bacteria,1V786@1239|Firmicutes,24HBF@186801|Clostridia	186801|Clostridia	C	Belongs to the V-ATPase proteolipid subunit family	ntpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
DEZH2_k127_6008075_5	1123075.AUDP01000020_gene1465	1.913e-05	54.0	COG1390@1|root,COG1390@2|Bacteria,1VDHZ@1239|Firmicutes,24H5N@186801|Clostridia,3WKRC@541000|Ruminococcaceae	186801|Clostridia	C	ATP synthase (E/31 kDa) subunit	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
DEZH2_k127_6008075_3	555088.DealDRAFT_1681	3.951e-30	134.0	COG1527@1|root,COG1527@2|Bacteria,1U6WZ@1239|Firmicutes,249XD@186801|Clostridia	186801|Clostridia	C	subunit c	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
DEZH2_k127_6008075_4	1120998.AUFC01000008_gene1083	2.387e-23	102.0	COG1436@1|root,COG1436@2|Bacteria,1VAX7@1239|Firmicutes,24MXC@186801|Clostridia,3WDN4@538999|Clostridiales incertae sedis	186801|Clostridia	C	ATP synthase (F/14-kDa) subunit	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
DEZH2_k127_6008075_1	1384066.JAGT01000001_gene452	1.091e-68	239.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,3WGBK@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	ntpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
DEZH2_k127_6022133_0	1392491.JIAE01000001_gene2299	5.684e-217	680.0	COG4108@1|root,COG4108@2|Bacteria,1TPYT@1239|Firmicutes,247X3@186801|Clostridia,3WGUR@541000|Ruminococcaceae	186801|Clostridia	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
DEZH2_k127_6039167_3	1280673.AUJJ01000013_gene1699	4.253e-43	166.0	COG1653@1|root,COG1653@2|Bacteria,1TPWV@1239|Firmicutes,24AWQ@186801|Clostridia,4BYP2@830|Butyrivibrio	186801|Clostridia	G	Domain of unknown function (DUF3502)	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	DUF3502,SBP_bac_1,SBP_bac_8
DEZH2_k127_6039167_1	1280680.AUJU01000008_gene160	2.248e-83	284.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V8U9@1239|Firmicutes,24J0N@186801|Clostridia,4C0Y8@830|Butyrivibrio	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC,Response_reg
DEZH2_k127_6039167_0	658655.HMPREF0988_00636	3.181e-132	441.0	COG2972@1|root,COG2972@2|Bacteria,1U6WN@1239|Firmicutes,24CTB@186801|Clostridia,27NM0@186928|unclassified Lachnospiraceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
DEZH2_k127_6039167_2	1151292.QEW_0855	3.399e-51	188.0	COG0778@1|root,COG0778@2|Bacteria,1VDE9@1239|Firmicutes,24QEX@186801|Clostridia	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DEZH2_k127_6043367_2	658655.HMPREF0988_00635	2.661e-74	259.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1URF2@1239|Firmicutes,24BBP@186801|Clostridia,27K82@186928|unclassified Lachnospiraceae	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC,Response_reg
DEZH2_k127_6043367_1	658655.HMPREF0988_00636	2.097e-107	369.0	COG2972@1|root,COG2972@2|Bacteria,1U6WN@1239|Firmicutes,24CTB@186801|Clostridia,27NM0@186928|unclassified Lachnospiraceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
DEZH2_k127_6043367_0	1291050.JAGE01000001_gene746	1.36e-147	473.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,3WGD9@541000|Ruminococcaceae	186801|Clostridia	L	Belongs to the DEAD box helicase family	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
DEZH2_k127_6044550_0	246194.CHY_0159	9.302e-27	118.0	2DMAW@1|root,32EM1@2|Bacteria,1UPNC@1239|Firmicutes,25HJQ@186801|Clostridia,42JH2@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6044550_1	340099.Teth39_1760	6.091e-08	59.0	COG2206@1|root,COG2206@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,42F3X@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
DEZH2_k127_6052134_3	398512.JQKC01000005_gene5582	9.609e-43	159.0	COG1051@1|root,COG1051@2|Bacteria,1V81X@1239|Firmicutes,24M8P@186801|Clostridia,3WKW7@541000|Ruminococcaceae	186801|Clostridia	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
DEZH2_k127_6052134_2	509191.AEDB02000043_gene4816	7.362e-47	176.0	COG1739@1|root,COG1739@2|Bacteria,1V6MQ@1239|Firmicutes,248W7@186801|Clostridia,3WIHN@541000|Ruminococcaceae	186801|Clostridia	S	YigZ family	yvyE	-	-	-	-	-	-	-	-	-	-	-	DUF1949,UPF0029
DEZH2_k127_6052134_1	1392491.JIAE01000001_gene599	6.379e-102	336.0	COG0217@1|root,COG0217@2|Bacteria,1TPP5@1239|Firmicutes,247NK@186801|Clostridia,3WHDN@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulatory protein	yebC	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
DEZH2_k127_6052134_0	1410638.JHXJ01000039_gene985	3.316e-113	375.0	COG0563@1|root,COG1302@1|root,COG0563@2|Bacteria,COG1302@2|Bacteria,1V1TU@1239|Firmicutes,24E60@186801|Clostridia,3WJ2N@541000|Ruminococcaceae	186801|Clostridia	F	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Asp23,IPT
DEZH2_k127_6052134_4	445972.ANACOL_01368	6.8e-11	68.0	COG0425@1|root,COG0425@2|Bacteria,1V6BY@1239|Firmicutes,24JW8@186801|Clostridia,3WJCH@541000|Ruminococcaceae	186801|Clostridia	O	DsrE/DsrF-like family	yedF	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE,TusA
DEZH2_k127_6054244_0	1304880.JAGB01000001_gene185	1.444e-63	224.0	COG1536@1|root,COG1536@2|Bacteria,1TP01@1239|Firmicutes,2480B@186801|Clostridia	186801|Clostridia	N	Flagellar motor switch protein flig	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
DEZH2_k127_6054244_1	1380391.JIAS01000016_gene406	3.861e-08	65.0	COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,2TR6J@28211|Alphaproteobacteria,2JQ4P@204441|Rhodospirillales	204441|Rhodospirillales	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
DEZH2_k127_6120333_2	1121904.ARBP01000008_gene3237	6.319e-05	49.0	COG1680@1|root,COG1680@2|Bacteria,4NGZR@976|Bacteroidetes,47M6K@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
DEZH2_k127_6120333_1	699246.HMPREF0868_0255	5.835e-74	256.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24APG@186801|Clostridia,267UB@186813|unclassified Clostridiales	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
DEZH2_k127_6120333_0	699246.HMPREF0868_0254	2.116e-74	266.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,267SU@186813|unclassified Clostridiales	186801|Clostridia	S	Insulinase (Peptidase family M16)	ymfH	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
DEZH2_k127_61281_0	699246.HMPREF0868_1289	0.0	1010.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,267YZ@186813|unclassified Clostridiales	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
DEZH2_k127_6150891_0	1280673.AUJJ01000013_gene1701	4.067e-77	278.0	COG2972@1|root,COG2972@2|Bacteria,1VUNN@1239|Firmicutes,24H81@186801|Clostridia,4C21F@830|Butyrivibrio	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
DEZH2_k127_6150891_1	1449063.JMLS01000039_gene714	5.641e-17	86.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UCUQ@1239|Firmicutes,4HC5Q@91061|Bacilli,26QMW@186822|Paenibacillaceae	91061|Bacilli	T	PFAM response regulator receiver	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
DEZH2_k127_6181406_0	658655.HMPREF0988_02770	2.333e-102	340.0	COG3507@1|root,COG3507@2|Bacteria,1UYIB@1239|Firmicutes,24975@186801|Clostridia,27MGB@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
DEZH2_k127_6181406_1	632292.Calhy_2344	2.259e-55	208.0	COG1172@1|root,COG1172@2|Bacteria,1V9PU@1239|Firmicutes,24PGN@186801|Clostridia	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_6185602_0	1195236.CTER_3520	3.161e-196	623.0	COG1252@1|root,COG1252@2|Bacteria,1TR6X@1239|Firmicutes,249J5@186801|Clostridia	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	DoxD,DoxX,Pyr_redox_2
DEZH2_k127_6185602_2	1487921.DP68_03445	5.919e-58	207.0	2C2FW@1|root,32RAE@2|Bacteria,1V7TJ@1239|Firmicutes,24JU9@186801|Clostridia,36U9N@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6185602_4	1235790.C805_00549	1.018e-05	55.0	COG3212@1|root,COG3212@2|Bacteria,1UVDK@1239|Firmicutes,24I8R@186801|Clostridia,25YMX@186806|Eubacteriaceae	186801|Clostridia	S	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
DEZH2_k127_6185602_3	351627.Csac_2727	1.796e-28	132.0	COG2207@1|root,COG2207@2|Bacteria,1TTA3@1239|Firmicutes,25BES@186801|Clostridia	186801|Clostridia	K	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,dCache_1
DEZH2_k127_6185602_5	1123037.AUDE01000012_gene211	0.0001534	54.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,4NI4E@976|Bacteroidetes,1HZZR@117743|Flavobacteriia	976|Bacteroidetes	S	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD
DEZH2_k127_6185602_1	1121335.Clst_1451	3.919e-84	293.0	COG1179@1|root,COG1179@2|Bacteria,1TQ7A@1239|Firmicutes,248RA@186801|Clostridia,3WG8S@541000|Ruminococcaceae	186801|Clostridia	H	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1	thiF	-	-	ko:K22132	-	-	-	-	ko00000,ko03016	-	-	-	ThiF
DEZH2_k127_6198270_2	720554.Clocl_3085	7.625e-69	242.0	COG1641@1|root,COG1641@2|Bacteria,1TPAV@1239|Firmicutes,247ZH@186801|Clostridia,3WGU1@541000|Ruminococcaceae	186801|Clostridia	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
DEZH2_k127_6198270_1	663278.Ethha_1296	4.318e-74	261.0	COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,3WHWU@541000|Ruminococcaceae	186801|Clostridia	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
DEZH2_k127_6198270_3	927704.SELR_02550	1.203e-61	225.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,4H3JI@909932|Negativicutes	909932|Negativicutes	S	TIGR00268 family	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,Asn_synthase,NAD_synthase
DEZH2_k127_6198270_0	1392491.JIAE01000001_gene1495	3.84e-147	471.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,3WG91@541000|Ruminococcaceae	186801|Clostridia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
DEZH2_k127_6216175_0	509191.AEDB02000094_gene4301	2.381e-61	218.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,3WGE4@541000|Ruminococcaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DEZH2_k127_6216175_3	742741.HMPREF9475_01227	3.327e-15	82.0	COG1846@1|root,COG1846@2|Bacteria,1VCZM@1239|Firmicutes,25CQG@186801|Clostridia,2240A@1506553|Lachnoclostridium	186801|Clostridia	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MarR
DEZH2_k127_6216175_1	1195236.CTER_4863	5.757e-27	119.0	COG1266@1|root,COG1266@2|Bacteria,1V47I@1239|Firmicutes,24H0K@186801|Clostridia	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
DEZH2_k127_6216175_2	1121943.KB899992_gene2086	8.532e-19	95.0	COG2865@1|root,COG2865@2|Bacteria,1RDDZ@1224|Proteobacteria,1S277@1236|Gammaproteobacteria,1XPDI@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6216175_4	572547.Amico_1912	8.907e-09	68.0	COG1933@1|root,COG4260@1|root,COG1933@2|Bacteria,COG4260@2|Bacteria,3TBKD@508458|Synergistetes	508458|Synergistetes	L	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,zinc_ribbon_2
DEZH2_k127_6236894_3	293826.Amet_4100	1.021e-23	101.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,36EMP@31979|Clostridiaceae	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
DEZH2_k127_6236894_0	1121335.Clst_0904	1.762e-219	695.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,3WGMQ@541000|Ruminococcaceae	186801|Clostridia	C	hydrogenase large subunit	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,Fer4_9,NADH-G_4Fe-4S_3
DEZH2_k127_6236894_5	1392491.JIAE01000001_gene1208	4.965e-07	54.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,3WGE5@541000|Ruminococcaceae	186801|Clostridia	D	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
DEZH2_k127_6236894_1	1392491.JIAE01000001_gene1208	1.333e-202	638.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,3WGE5@541000|Ruminococcaceae	186801|Clostridia	D	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
DEZH2_k127_6236894_2	699246.HMPREF0868_0962	2.595e-88	298.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,24967@186801|Clostridia,267QK@186813|unclassified Clostridiales	186801|Clostridia	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
DEZH2_k127_6236894_4	690585.JNNU01000009_gene616	9.48e-14	84.0	COG0747@1|root,COG0747@2|Bacteria,1PUV0@1224|Proteobacteria,2TVJT@28211|Alphaproteobacteria,4BCGN@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
DEZH2_k127_6244423_0	203119.Cthe_2096	1.313e-287	893.0	COG0143@1|root,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,3WGEI@541000|Ruminococcaceae	186801|Clostridia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
DEZH2_k127_625580_2	1392491.JIAE01000001_gene2310	1.662e-75	257.0	COG0232@1|root,COG0232@2|Bacteria,1TPEI@1239|Firmicutes,247Q1@186801|Clostridia,3WNBX@541000|Ruminococcaceae	186801|Clostridia	F	Phosphohydrolase-associated domain	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
DEZH2_k127_625580_1	203119.Cthe_1172	4.681e-83	289.0	COG1146@1|root,COG2006@1|root,COG1146@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,3WHJ8@541000|Ruminococcaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
DEZH2_k127_625580_0	1410638.JHXJ01000032_gene248	3.446e-138	457.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,3WGKX@541000|Ruminococcaceae	186801|Clostridia	L	ATP-dependent DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
DEZH2_k127_6271094_7	1280676.AUJO01000005_gene502	6.908e-14	72.0	COG0246@1|root,COG0246@2|Bacteria,1TQ97@1239|Firmicutes,247TG@186801|Clostridia,4BX01@830|Butyrivibrio	186801|Clostridia	G	Mannitol dehydrogenase C-terminal domain	-	-	1.1.1.57	ko:K00040	ko00040,ko01100,map00040,map01100	M00061	R02454	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
DEZH2_k127_6271094_1	394503.Ccel_0214	5.272e-170	549.0	COG1904@1|root,COG1904@2|Bacteria,1TRI0@1239|Firmicutes,248C0@186801|Clostridia,36DFN@31979|Clostridiaceae	186801|Clostridia	G	glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
DEZH2_k127_6271094_2	877415.JNJQ01000002_gene2289	3.192e-110	365.0	COG0546@1|root,COG0546@2|Bacteria,1V1RB@1239|Firmicutes	1239|Firmicutes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
DEZH2_k127_6271094_0	877415.JNJQ01000002_gene2288	2.191e-250	783.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes	1239|Firmicutes	G	hydrolase, family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
DEZH2_k127_6271094_3	632292.Calhy_2344	3.598e-70	250.0	COG1172@1|root,COG1172@2|Bacteria,1V9PU@1239|Firmicutes,24PGN@186801|Clostridia	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_6271094_6	632292.Calhy_2345	3.287e-41	166.0	COG1609@1|root,COG1609@2|Bacteria,1UZFZ@1239|Firmicutes,24H13@186801|Clostridia	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6271094_5	1536773.R70331_07060	6.072e-57	210.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,26VZC@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_6271094_4	1536773.R70331_07055	1.078e-64	226.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli,26UYP@186822|Paenibacillaceae	91061|Bacilli	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
DEZH2_k127_628805_1	699246.HMPREF0868_0832	3.826e-49	192.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,248RH@186801|Clostridia	186801|Clostridia	K	Cell envelope-like function transcriptional attenuator common domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
DEZH2_k127_628805_2	398512.JQKC01000002_gene1760	7.686e-42	155.0	COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,24MMM@186801|Clostridia,3WJT1@541000|Ruminococcaceae	186801|Clostridia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
DEZH2_k127_628805_0	398512.JQKC01000002_gene1761	3.533e-96	317.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,3WGUG@541000|Ruminococcaceae	186801|Clostridia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
DEZH2_k127_6304804_2	416591.Tlet_0803	2.262e-70	247.0	COG0410@1|root,COG0410@2|Bacteria,2GCPJ@200918|Thermotogae	200918|Thermotogae	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
DEZH2_k127_6304804_1	1209989.TepiRe1_1740	7.213e-72	250.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia,42FCE@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM ABC transporter related	braF	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
DEZH2_k127_6304804_5	1121472.AQWN01000006_gene1810	9.983e-17	85.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,248WH@186801|Clostridia,260FB@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DEZH2_k127_6304804_4	1408424.JHYI01000004_gene3410	1.657e-21	100.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,4HBB8@91061|Bacilli,1ZBKN@1386|Bacillus	91061|Bacilli	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DEZH2_k127_6304804_3	484770.UFO1_4518	3.495e-33	139.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,4H29T@909932|Negativicutes	909932|Negativicutes	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DEZH2_k127_6304804_6	1123400.KB904760_gene2126	1.72e-15	89.0	COG0683@1|root,COG0683@2|Bacteria,1MW99@1224|Proteobacteria	1224|Proteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DEZH2_k127_6304804_0	1120746.CCNL01000017_gene3249	7.726e-116	384.0	COG2233@1|root,COG2233@2|Bacteria,2NP6F@2323|unclassified Bacteria	2|Bacteria	F	Permease family	pyrP	GO:0003674,GO:0005215,GO:0005350,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0006810,GO:0006855,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0015205,GO:0015210,GO:0015238,GO:0015851,GO:0015855,GO:0015857,GO:0015893,GO:0016020,GO:0016021,GO:0017144,GO:0019860,GO:0022857,GO:0031224,GO:0031226,GO:0034641,GO:0042221,GO:0042493,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072527,GO:0072529,GO:0072531,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1903791,GO:1904082	-	ko:K02824,ko:K03458,ko:K09016	-	-	-	-	ko00000,ko02000	2.A.40,2.A.40.1.1,2.A.40.1.2,2.A.40.1.3	-	iECO103_1326.ECO103_1052,iECUMN_1333.ECUMN_1189,iLJ478.TM0819,iSFxv_1172.SFxv_2795,iS_1188.S2690	Xan_ur_permease
DEZH2_k127_6311897_2	399795.CtesDRAFT_PD3915	1.266e-25	109.0	2CKE6@1|root,32ZEV@2|Bacteria,1NBRM@1224|Proteobacteria,2VX50@28216|Betaproteobacteria,4AIV1@80864|Comamonadaceae	28216|Betaproteobacteria	S	Family of unknown function (DUF5329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5329
DEZH2_k127_6311897_1	1163617.SCD_n00546	4.269e-29	122.0	2CIC4@1|root,3328Z@2|Bacteria,1N7FS@1224|Proteobacteria,2VX81@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6311897_0	580332.Slit_1233	2.771e-68	238.0	COG3133@1|root,COG3133@2|Bacteria,1PCU8@1224|Proteobacteria,2WAJP@28216|Betaproteobacteria,44WK0@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Glycine zipper 2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	Rick_17kDa_Anti
DEZH2_k127_6336479_4	431943.CKL_1689	1.793e-88	302.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
DEZH2_k127_6336479_2	935948.KE386494_gene532	1.329e-116	391.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,42F2D@68295|Thermoanaerobacterales	186801|Clostridia	V	PFAM multi antimicrobial extrusion protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
DEZH2_k127_6336479_5	657322.FPR_06600	5.527e-41	164.0	COG0226@1|root,COG0226@2|Bacteria,1VT8I@1239|Firmicutes,24IAW@186801|Clostridia,3WJDA@541000|Ruminococcaceae	186801|Clostridia	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
DEZH2_k127_6336479_7	1280692.AUJL01000007_gene1391	4.307e-15	77.0	COG2963@1|root,COG2963@2|Bacteria,1VIRY@1239|Firmicutes,24QMV@186801|Clostridia,36NP8@31979|Clostridiaceae	186801|Clostridia	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_Tnp_1
DEZH2_k127_6336479_8	398511.BpOF4_02310	0.0002003	45.0	2EFZF@1|root,339RM@2|Bacteria,1VMG6@1239|Firmicutes,4HR8G@91061|Bacilli,1ZK3J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6336479_3	545694.TREPR_2998	2.013e-93	317.0	COG0407@1|root,COG0407@2|Bacteria,2J8ZX@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DEZH2_k127_6336479_1	545695.TREAZ_2889	6.859e-130	424.0	COG1063@1|root,COG1063@2|Bacteria,2J5R7@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Alcohol dehydrogenase GroES-like	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
DEZH2_k127_6336479_0	545695.TREAZ_2888	1.224e-166	529.0	COG1063@1|root,COG1063@2|Bacteria,2J6S3@203691|Spirochaetes	203691|Spirochaetes	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
DEZH2_k127_6336479_6	697281.Mahau_1767	1.768e-24	104.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,42EWH@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Ribulose-phosphate 3-epimerase	rpe	-	5.1.3.1	ko:K01783,ko:K17195	ko00030,ko00040,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529,R09031	RC00540,RC03111	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
DEZH2_k127_6347962_0	357809.Cphy_3123	1.254e-202	642.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,22124@1506553|Lachnoclostridium	186801|Clostridia	C	COG COG0674 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, alpha subunit	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
DEZH2_k127_6347962_1	536227.CcarbDRAFT_4012	2.335e-130	421.0	COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,25CAJ@186801|Clostridia,36WSB@31979|Clostridiaceae	186801|Clostridia	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
DEZH2_k127_6347962_2	1131462.DCF50_p2427	1.567e-54	192.0	COG1592@1|root,COG1592@2|Bacteria,1VB12@1239|Firmicutes,24JQ6@186801|Clostridia,262FT@186807|Peptococcaceae	186801|Clostridia	C	PFAM Rubredoxin-type Fe(Cys)4 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6347962_4	742738.HMPREF9460_01101	1.158e-05	48.0	COG2361@1|root,COG2361@2|Bacteria,1VFEB@1239|Firmicutes,24QN5@186801|Clostridia	186801|Clostridia	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
DEZH2_k127_6347962_3	138119.DSY2774	3.419e-14	74.0	COG1669@1|root,COG1669@2|Bacteria,1V5FK@1239|Firmicutes,24WNF@186801|Clostridia	186801|Clostridia	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
DEZH2_k127_6385908_1	370438.PTH_2331	4.426e-47	177.0	COG0765@1|root,COG0834@1|root,COG0765@2|Bacteria,COG0834@2|Bacteria,1TPM3@1239|Firmicutes,248UY@186801|Clostridia,261MM@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1,SBP_bac_3
DEZH2_k127_6385908_0	1408322.JHYK01000002_gene1244	1.358e-106	350.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia,27IAG@186928|unclassified Lachnospiraceae	186801|Clostridia	E	ATPases associated with a variety of cellular activities	glnQ	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
DEZH2_k127_6430253_0	699246.HMPREF0868_1518	1.689e-79	270.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,268HA@186813|unclassified Clostridiales	186801|Clostridia	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
DEZH2_k127_6430253_4	1121344.JHZO01000003_gene1128	4.509e-07	57.0	COG2163@1|root,COG2163@2|Bacteria,1VEPA@1239|Firmicutes,24UP0@186801|Clostridia	186801|Clostridia	J	COG2163 Ribosomal protein L14E L6E L27E	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6430253_2	699246.HMPREF0868_1516	6.032e-37	139.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,24MQE@186801|Clostridia,269B1@186813|unclassified Clostridiales	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
DEZH2_k127_6430253_3	546269.HMPREF0389_01736	2.336e-16	79.0	COG0257@1|root,COG0257@2|Bacteria,1VK4F@1239|Firmicutes,24UGF@186801|Clostridia,25RZI@186804|Peptostreptococcaceae	186801|Clostridia	J	Ribosomal protein L36	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
DEZH2_k127_6430253_1	699246.HMPREF0868_1514	6.816e-58	203.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,26987@186813|unclassified Clostridiales	186801|Clostridia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
DEZH2_k127_6430253_5	1235835.C814_02987	5.826e-07	51.0	COG0100@1|root,COG0100@2|Bacteria,1V3IK@1239|Firmicutes,24HIK@186801|Clostridia,3WIYT@541000|Ruminococcaceae	186801|Clostridia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
DEZH2_k127_6465885_1	665956.HMPREF1032_01496	3.672e-101	338.0	COG2221@1|root,COG4624@1|root,COG2221@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,24YQ5@186801|Clostridia,3WGXS@541000|Ruminococcaceae	186801|Clostridia	C	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,PAS
DEZH2_k127_6465885_0	1280390.CBQR020000120_gene3144	1.818e-172	548.0	COG2208@1|root,COG2208@2|Bacteria,1TQUC@1239|Firmicutes	1239|Firmicutes	KT	stage ii sporulation protein e	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
DEZH2_k127_6465885_2	556261.HMPREF0240_00629	1.25e-30	124.0	COG4922@1|root,COG4922@2|Bacteria,1VEC0@1239|Firmicutes,24JEI@186801|Clostridia,36PYK@31979|Clostridiaceae	186801|Clostridia	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
DEZH2_k127_6467830_0	203119.Cthe_2249	6.307e-191	623.0	COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,3WGP3@541000|Ruminococcaceae	186801|Clostridia	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
DEZH2_k127_6467830_1	1304284.L21TH_0301	3.782e-180	572.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,36DDF@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
DEZH2_k127_6467830_2	1392491.JIAE01000001_gene1571	2.064e-122	403.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,3WGJJ@541000|Ruminococcaceae	186801|Clostridia	U	Type II IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
DEZH2_k127_6467830_3	699246.HMPREF0868_0732	8.571e-21	107.0	COG4965@1|root,COG4965@2|Bacteria,1W08K@1239|Firmicutes,254C1@186801|Clostridia	186801|Clostridia	U	Type ii secretion system	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
DEZH2_k127_6467830_6	588581.Cpap_0021	0.0005555	44.0	2EHSI@1|root,33BI9@2|Bacteria,1VK7K@1239|Firmicutes	1239|Firmicutes	S	Putative Flagellin, Flp1-like, domain	-	-	-	-	-	-	-	-	-	-	-	-	Flp1_like
DEZH2_k127_6467830_5	575593.HMPREF0491_00914	7.812e-09	67.0	COG1716@1|root,COG1716@2|Bacteria,1V0I9@1239|Firmicutes,24F2G@186801|Clostridia,27PEI@186928|unclassified Lachnospiraceae	186801|Clostridia	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
DEZH2_k127_6467830_4	411490.ANACAC_03681	2.376e-13	73.0	COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
DEZH2_k127_6485153_1	645991.Sgly_3164	2.895e-137	450.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	regB	-	2.7.13.3	ko:K07706,ko:K15011	ko02020,ko02024,map02020,map02024	M00495,M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
DEZH2_k127_6485153_0	1131462.DCF50_p2770	8.668e-216	680.0	COG0784@1|root,COG2206@1|root,COG0784@2|Bacteria,COG2206@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,26242@186807|Peptococcaceae	186801|Clostridia	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,GAF,GAF_2,HAMP,HD,HD_5,PAS_9,Response_reg
DEZH2_k127_6486446_4	203119.Cthe_0181	2.501e-50	185.0	COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia,3WIM6@541000|Ruminococcaceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
DEZH2_k127_6486446_3	1392491.JIAE01000001_gene1358	7.175e-55	205.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,3WIS5@541000|Ruminococcaceae	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
DEZH2_k127_6486446_0	1304880.JAGB01000002_gene1747	2.829e-235	736.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2495J@186801|Clostridia	186801|Clostridia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0036440,GO:0046912,GO:0050450	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS03250	HMGL-like
DEZH2_k127_6486446_2	1095747.HMPREF1049_1734	1.409e-70	242.0	COG2131@1|root,COG2131@2|Bacteria,3794S@32066|Fusobacteria	32066|Fusobacteria	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
DEZH2_k127_6486446_1	755731.Clo1100_0670	8.408e-167	533.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,36FIT@31979|Clostridiaceae	186801|Clostridia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
DEZH2_k127_6486446_5	1089553.Tph_c07660	1.058e-44	165.0	COG2033@1|root,COG2033@2|Bacteria,1VA34@1239|Firmicutes,24J9I@186801|Clostridia,42H0Z@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Desulfoferrodoxin ferrous iron-binding region	dfx	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0010035,GO:0016491,GO:0016721,GO:0019430,GO:0022900,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
DEZH2_k127_6486446_6	994573.T472_0206155	1.098e-34	141.0	COG4485@1|root,COG4485@2|Bacteria,1TRR1@1239|Firmicutes,24BHM@186801|Clostridia,36VYW@31979|Clostridiaceae	186801|Clostridia	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	GtrA,YfhO
DEZH2_k127_6488802_0	398512.JQKC01000001_gene2326	6.753e-147	472.0	COG2207@1|root,COG2207@2|Bacteria,1TQDS@1239|Firmicutes,24907@186801|Clostridia,3WGSU@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
DEZH2_k127_6488802_2	552396.HMPREF0863_00209	3.521e-46	182.0	COG3307@1|root,COG3307@2|Bacteria,1V4W4@1239|Firmicutes,3VNTJ@526524|Erysipelotrichia	526524|Erysipelotrichia	M	Psort location CytoplasmicMembrane, score 9.99	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
DEZH2_k127_6488802_1	397287.C807_00899	5.754e-52	188.0	COG3663@1|root,COG3663@2|Bacteria,1V6GI@1239|Firmicutes,24HD8@186801|Clostridia,27MP7@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
DEZH2_k127_6488802_3	1414720.CBYM010000007_gene1072	6.062e-17	83.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,247NA@186801|Clostridia,36EN2@31979|Clostridiaceae	186801|Clostridia	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
DEZH2_k127_651741_3	1140001.I571_00970	1.047e-131	424.0	COG4670@1|root,COG4670@2|Bacteria,1TQ4Z@1239|Firmicutes,4HDEN@91061|Bacilli,4B0WK@81852|Enterococcaceae	91061|Bacilli	I	Malonate decarboxylase, alpha subunit, transporter	mdcA	-	2.3.1.187	ko:K13929	-	-	R08944	RC00012,RC00014	ko00000,ko01000,ko02000	3.B.1.1.4	-	-	Mal_decarbox_Al
DEZH2_k127_651741_6	536227.CcarbDRAFT_0888	2.427e-71	252.0	COG0583@1|root,COG0583@2|Bacteria,1TST3@1239|Firmicutes,25C70@186801|Clostridia,36WQS@31979|Clostridiaceae	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
DEZH2_k127_651741_0	509191.AEDB02000037_gene2105	6.401e-173	545.0	COG3177@1|root,COG3177@2|Bacteria,1TZWX@1239|Firmicutes,247MZ@186801|Clostridia,3WHZR@541000|Ruminococcaceae	186801|Clostridia	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,HTH_17
DEZH2_k127_651741_15	1033739.CAEU01000018_gene2396	6.435e-16	80.0	COG1925@1|root,COG1925@2|Bacteria,1VA0R@1239|Firmicutes,4HKGA@91061|Bacilli,26FVP@186818|Planococcaceae	91061|Bacilli	G	phosphocarrier protein	ptsH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0043610,GO:0044424,GO:0044464,GO:0050789,GO:0065007	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
DEZH2_k127_651741_1	858215.Thexy_2227	1.036e-159	515.0	COG1299@1|root,COG1445@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,1TPKU@1239|Firmicutes,248V6@186801|Clostridia,42FID@68295|Thermoanaerobacterales	186801|Clostridia	G	PTS system, fructose subfamily, IIC subunit	fruA	-	2.7.1.202	ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIC,PTS_IIB
DEZH2_k127_651741_7	1304880.JAGB01000001_gene959	4.125e-68	242.0	COG1105@1|root,COG1105@2|Bacteria,1TQ36@1239|Firmicutes,249RK@186801|Clostridia	186801|Clostridia	H	Belongs to the carbohydrate kinase PfkB family. LacC subfamily	pfkB	-	2.7.1.56	ko:K00882	ko00051,map00051	-	R02071	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
DEZH2_k127_651741_12	264732.Moth_0608	1.236e-45	174.0	COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,25C4D@186801|Clostridia,42J47@68295|Thermoanaerobacterales	186801|Clostridia	K	DeoR C terminal sensor domain	-	-	-	ko:K02081,ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
DEZH2_k127_651741_13	1031288.AXAA01000010_gene475	2.491e-35	140.0	COG1762@1|root,COG1762@2|Bacteria,1VA2N@1239|Firmicutes,24M3K@186801|Clostridia,36WK6@31979|Clostridiaceae	186801|Clostridia	GT	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	2.7.1.202	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
DEZH2_k127_651741_2	555079.Toce_1427	3.077e-157	515.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,42FHW@68295|Thermoanaerobacterales	186801|Clostridia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsP	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
DEZH2_k127_651741_16	1078085.HMPREF1210_00098	0.0009181	45.0	COG2207@1|root,COG2207@2|Bacteria,1TQD7@1239|Firmicutes,4HHKY@91061|Bacilli,26HT4@186818|Planococcaceae	91061|Bacilli	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC
DEZH2_k127_651741_9	1123511.KB905880_gene2444	1.663e-67	247.0	COG1850@1|root,COG1850@2|Bacteria,1TSZQ@1239|Firmicutes,4H3SI@909932|Negativicutes	1239|Firmicutes	G	ribulose- bisphosphate carboxylase large chain	mtnW	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009853,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0016984,GO:0043094,GO:0044237	5.3.2.5	ko:K08965	ko00270,ko01100,map00270,map01100	M00034	R07393	RC02421	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
DEZH2_k127_651741_10	525904.Tter_0092	1.185e-60	222.0	COG0508@1|root,COG0508@2|Bacteria,2NNYD@2323|unclassified Bacteria	2|Bacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	pdhC	-	1.2.4.1,2.3.1.12	ko:K00162,ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R02569,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
DEZH2_k127_651741_5	553973.CLOHYLEM_05690	2.974e-102	342.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,250C5@186801|Clostridia,222PR@1506553|Lachnoclostridium	186801|Clostridia	C	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	E1_dh
DEZH2_k127_651741_4	553973.CLOHYLEM_05689	2.979e-115	381.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,221X6@1506553|Lachnoclostridium	186801|Clostridia	C	Psort location Cytoplasmic, score 8.87	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
DEZH2_k127_651741_11	706191.PANA_0833	1.725e-46	177.0	COG1349@1|root,COG1349@2|Bacteria,1MUJG@1224|Proteobacteria,1RNW4@1236|Gammaproteobacteria,3VYMF@53335|Pantoea	1236|Gammaproteobacteria	K	DeoR C terminal sensor domain	srlR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K02468	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
DEZH2_k127_651741_8	1291050.JAGE01000001_gene549	8.578e-68	239.0	COG0235@1|root,COG0235@2|Bacteria,1TS5G@1239|Firmicutes,248NY@186801|Clostridia,3WHFE@541000|Ruminococcaceae	186801|Clostridia	G	L-fuculose phosphate aldolase	fucA	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
DEZH2_k127_651741_14	180332.JTGN01000004_gene2623	7.839e-27	121.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	HTH_IclR,Peripla_BP_4
DEZH2_k127_6540666_1	397287.C807_02447	2.034e-75	259.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,27IA2@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
DEZH2_k127_6540666_0	1469948.JPNB01000001_gene877	8.62e-101	338.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,36DTM@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440,ko:K17214	ko02010,map02010	M00212,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_6540666_2	931276.Cspa_c42880	5.847e-22	97.0	COG1082@1|root,COG1082@2|Bacteria,1UY4G@1239|Firmicutes,24CXG@186801|Clostridia,36W1Q@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_6545449_8	1131462.DCF50_p2284	1.022e-76	258.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,2610Q@186807|Peptococcaceae	186801|Clostridia	C	formate C-acetyltransferase glycine radical	pflB	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
DEZH2_k127_6545449_2	665956.HMPREF1032_03551	4.301e-123	400.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,3WGGK@541000|Ruminococcaceae	186801|Clostridia	C	TIGRFAM formate acetyltransferase	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
DEZH2_k127_6545449_1	1120998.AUFC01000001_gene2032	7.425e-175	556.0	28IKA@1|root,2Z8M2@2|Bacteria,1TTAG@1239|Firmicutes,24CCS@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6545449_4	1131462.DCF50_p296	5.828e-121	394.0	COG2116@1|root,COG2116@2|Bacteria,1TRTT@1239|Firmicutes,24BU5@186801|Clostridia,260JS@186807|Peptococcaceae	186801|Clostridia	P	PFAM Formate nitrite transporter	fnt	-	-	ko:K21993	-	-	-	-	ko00000,ko02000	1.A.16.2	-	-	Form_Nir_trans
DEZH2_k127_6545449_0	2325.TKV_c19930	2.585e-272	846.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,42FHK@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM formate-tetrahydrofolate ligase FTHFS	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
DEZH2_k127_6545449_5	589865.DaAHT2_1287	7.764e-100	335.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria,2MIMG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
DEZH2_k127_6545449_7	1167006.UWK_02567	6.301e-88	297.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WM55@28221|Deltaproteobacteria,2MPY6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
DEZH2_k127_6545449_3	1128398.Curi_c21360	1.53e-122	398.0	COG0685@1|root,COG0685@2|Bacteria,1USZE@1239|Firmicutes,250HQ@186801|Clostridia	186801|Clostridia	C	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
DEZH2_k127_6545449_6	509191.AEDB02000064_gene502	1.823e-90	301.0	COG1410@1|root,COG1410@2|Bacteria,1V0F4@1239|Firmicutes,25CEI@186801|Clostridia	186801|Clostridia	E	PFAM Pterin binding enzyme	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
DEZH2_k127_6564845_0	1291050.JAGE01000002_gene3901	0.0	1408.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,2498I@186801|Clostridia,3WG9X@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,DAP_epimerase,MGS
DEZH2_k127_6564845_1	1392491.JIAE01000001_gene1399	1.159e-34	140.0	COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,3WGW1@541000|Ruminococcaceae	186801|Clostridia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
DEZH2_k127_6584660_0	699246.HMPREF0868_0789	8.023e-194	617.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,268V2@186813|unclassified Clostridiales	186801|Clostridia	J	Arginyl tRNA synthetase N terminal dom	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
DEZH2_k127_6584660_1	1121904.ARBP01000005_gene4596	6.484e-96	320.0	COG1432@1|root,COG1432@2|Bacteria,4NGF1@976|Bacteroidetes,47KWJ@768503|Cytophagia	976|Bacteroidetes	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
DEZH2_k127_659548_2	1210045.ALNP01000031_gene2616	1.185e-29	123.0	COG0726@1|root,COG0726@2|Bacteria,2HEQK@201174|Actinobacteria	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
DEZH2_k127_659548_0	1203606.HMPREF1526_03009	6.835e-150	483.0	COG3177@1|root,COG3177@2|Bacteria,1TQMC@1239|Firmicutes,248JU@186801|Clostridia,36GRI@31979|Clostridiaceae	186801|Clostridia	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,HTH_24
DEZH2_k127_659548_1	748727.CLJU_c20000	6.232e-61	214.0	COG0778@1|root,COG0778@2|Bacteria,1VCNK@1239|Firmicutes,24D29@186801|Clostridia,36GC4@31979|Clostridiaceae	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DEZH2_k127_659548_4	1150469.RSPPHO_03094	0.0007658	47.0	COG1396@1|root,COG1396@2|Bacteria,1N8AN@1224|Proteobacteria,2UA25@28211|Alphaproteobacteria,2JSP0@204441|Rhodospirillales	28211|Alphaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
DEZH2_k127_659548_3	555088.DealDRAFT_2803	1.928e-08	60.0	COG4679@1|root,COG4679@2|Bacteria,1VBSY@1239|Firmicutes,24PZB@186801|Clostridia	186801|Clostridia	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
DEZH2_k127_6611054_1	445972.ANACOL_00503	8.317e-15	89.0	COG3559@1|root,COG3559@2|Bacteria,1UJBP@1239|Firmicutes,25FWA@186801|Clostridia,3WM7J@541000|Ruminococcaceae	186801|Clostridia	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6611054_0	1121334.KB911066_gene968	2.781e-83	284.0	COG1131@1|root,COG1131@2|Bacteria,1TPQW@1239|Firmicutes,248F7@186801|Clostridia,3WI0G@541000|Ruminococcaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	ytrB	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_6622217_5	158190.SpiGrapes_0278	7.024e-20	91.0	COG4877@1|root,COG4877@2|Bacteria,2J8S8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6622217_2	1121344.JHZO01000007_gene2094	2.15e-120	395.0	COG0330@1|root,COG0330@2|Bacteria,1TRN5@1239|Firmicutes,248UU@186801|Clostridia,3WI4C@541000|Ruminococcaceae	186801|Clostridia	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
DEZH2_k127_6622217_1	1304880.JAGB01000002_gene2262	6.609e-122	402.0	COG0673@1|root,COG0673@2|Bacteria,1U4A4@1239|Firmicutes,249UF@186801|Clostridia	186801|Clostridia	E	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
DEZH2_k127_6622217_0	1499967.BAYZ01000068_gene1989	1.26e-159	509.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
DEZH2_k127_6622217_3	1536773.R70331_06830	5.783e-61	220.0	COG2207@1|root,COG2207@2|Bacteria,1V5I2@1239|Firmicutes,4HMB9@91061|Bacilli,26QSW@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_18
DEZH2_k127_6622217_4	720554.Clocl_0596	1.391e-40	155.0	COG2183@1|root,COG2183@2|Bacteria,1TPFE@1239|Firmicutes,248P0@186801|Clostridia,3WGWI@541000|Ruminococcaceae	186801|Clostridia	K	Tex-like protein N-terminal domain	yhgF	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
DEZH2_k127_662316_2	509191.AEDB02000035_gene2210	2.721e-48	177.0	COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,3WGGQ@541000|Ruminococcaceae	186801|Clostridia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
DEZH2_k127_662316_0	1392491.JIAE01000001_gene2536	4.687e-71	251.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,3WIRQ@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
DEZH2_k127_662316_1	1410638.JHXJ01000008_gene422	1.239e-64	224.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,3WGW0@541000|Ruminococcaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
DEZH2_k127_665814_0	1120746.CCNL01000005_gene108	4.51e-163	522.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2NPG9@2323|unclassified Bacteria	2|Bacteria	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	cdr	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
DEZH2_k127_665814_1	1291050.JAGE01000002_gene3468	4.602e-63	220.0	COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia,3WHA0@541000|Ruminococcaceae	186801|Clostridia	J	Metallo-beta-lactamase domain protein	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
DEZH2_k127_6694678_4	931276.Cspa_c47530	1.465e-99	334.0	COG0655@1|root,COG0655@2|Bacteria,1UYDQ@1239|Firmicutes,24BAR@186801|Clostridia,36H9Z@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DEZH2_k127_6694678_5	931276.Cspa_c42870	4.729e-46	169.0	COG1082@1|root,COG1082@2|Bacteria,1V67Z@1239|Firmicutes,24HF6@186801|Clostridia,36W32@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6694678_2	931276.Cspa_c42880	1.345e-130	425.0	COG1082@1|root,COG1082@2|Bacteria,1UY4G@1239|Firmicutes,24CXG@186801|Clostridia,36W1Q@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_6694678_0	931276.Cspa_c43160	4.666e-158	527.0	COG3664@1|root,COG4977@1|root,COG3664@2|Bacteria,COG4977@2|Bacteria,1TQGI@1239|Firmicutes,2490Q@186801|Clostridia,36GCA@31979|Clostridiaceae	186801|Clostridia	K	family 39	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	AraC_binding,Glyco_hydro_39,HTH_18
DEZH2_k127_6694678_1	1209989.TepiRe1_1688	1.304e-134	442.0	COG5026@1|root,COG5026@2|Bacteria,1TRWA@1239|Firmicutes,24BV4@186801|Clostridia	186801|Clostridia	G	PFAM hexokinase	-	-	2.7.1.1	ko:K00844	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04910,ko04930,ko04973,ko05230,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200,map04066,map04910,map04930,map04973,map05230	M00001,M00549	R00299,R00760,R00867,R01326,R01600,R01786,R01961,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	Hexokinase_1,Hexokinase_2
DEZH2_k127_6694678_3	1235802.C823_02002	1.083e-118	386.0	COG0673@1|root,COG0673@2|Bacteria,1TQFW@1239|Firmicutes,24BIG@186801|Clostridia,25YD2@186806|Eubacteriaceae	186801|Clostridia	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_6696089_2	509191.AEDB02000002_gene1217	1.032e-29	124.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia,3WJA4@541000|Ruminococcaceae	186801|Clostridia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
DEZH2_k127_6696089_0	411459.RUMOBE_01281	4.465e-97	326.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,3XYRA@572511|Blautia	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
DEZH2_k127_6696089_3	1089553.Tph_c19770	9.562e-23	108.0	COG3879@1|root,COG3879@2|Bacteria,1V0FG@1239|Firmicutes,24DRC@186801|Clostridia,42G46@68295|Thermoanaerobacterales	186801|Clostridia	S	Bacterial protein of unknown function (DUF881)	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
DEZH2_k127_6696089_4	720554.Clocl_1427	2.022e-22	106.0	COG3879@1|root,COG3879@2|Bacteria,1VTG1@1239|Firmicutes,24ZU5@186801|Clostridia,3WNA9@541000|Ruminococcaceae	186801|Clostridia	S	Bacterial protein of unknown function (DUF881)	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
DEZH2_k127_6696089_1	720554.Clocl_1431	7.351e-39	151.0	COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia,3WHAN@541000|Ruminococcaceae	186801|Clostridia	T	phosphate starvation-inducible protein	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
DEZH2_k127_6699982_0	877414.ATWA01000007_gene212	1.314e-155	500.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,267IG@186813|unclassified Clostridiales	186801|Clostridia	E	Receptor family ligand binding region	braC	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DEZH2_k127_6699982_1	1499684.CCNP01000018_gene1308	2.219e-29	131.0	COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1TS6T@1239|Firmicutes,247QK@186801|Clostridia,36IQ0@31979|Clostridiaceae	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
DEZH2_k127_6699982_2	657322.FPR_17820	0.0003126	51.0	COG0657@1|root,COG0657@2|Bacteria,1UEU5@1239|Firmicutes,24BRQ@186801|Clostridia	2|Bacteria	I	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
DEZH2_k127_670820_0	1280698.AUJS01000020_gene1358	7.366e-245	761.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,27WA9@189330|Dorea	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
DEZH2_k127_670820_1	509191.AEDB02000049_gene4417	1.465e-27	117.0	COG1394@1|root,COG1394@2|Bacteria,1TQ1Y@1239|Firmicutes,247TC@186801|Clostridia,3WHIG@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
DEZH2_k127_6712472_1	699246.HMPREF0868_0341	2.077e-47	175.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,268A6@186813|unclassified Clostridiales	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
DEZH2_k127_6712472_0	699246.HMPREF0868_0340	6.591e-65	236.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,2682V@186813|unclassified Clostridiales	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
DEZH2_k127_6720392_11	33035.JPJF01000004_gene1973	1.236e-15	85.0	COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24BAQ@186801|Clostridia	186801|Clostridia	V	PFAM SCP-like extracellular	safA	-	-	-	-	-	-	-	-	-	-	-	CAP,LysM
DEZH2_k127_6720392_12	180332.JTGN01000001_gene5139	3.22e-06	57.0	COG3432@1|root,COG3432@2|Bacteria,1V75P@1239|Firmicutes,24JAZ@186801|Clostridia	186801|Clostridia	K	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	DUF4364
DEZH2_k127_6720392_3	699246.HMPREF0868_0695	1.381e-120	399.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,268CF@186813|unclassified Clostridiales	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
DEZH2_k127_6720392_8	563008.HMPREF0665_00469	4.863e-25	104.0	COG1773@1|root,COG1773@2|Bacteria,4NHF0@976|Bacteroidetes,2FUN6@200643|Bacteroidia	976|Bacteroidetes	C	rubredoxin	rubR	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
DEZH2_k127_6720392_9	1121335.Clst_0494	8.062e-21	96.0	COG1534@1|root,COG1534@2|Bacteria,1VEGM@1239|Firmicutes,24QZB@186801|Clostridia,3WKIM@541000|Ruminococcaceae	186801|Clostridia	J	RNA-binding protein, YhbY family	yhbY	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
DEZH2_k127_6720392_1	699246.HMPREF0868_0691	2.671e-165	529.0	COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,268DD@186813|unclassified Clostridiales	186801|Clostridia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
DEZH2_k127_6720392_4	1392491.JIAE01000001_gene2049	1.153e-42	160.0	COG0211@1|root,COG0211@2|Bacteria,1V6HW@1239|Firmicutes,24N3D@186801|Clostridia,3WJU0@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
DEZH2_k127_6720392_10	720554.Clocl_1210	4.841e-17	87.0	COG2868@1|root,COG2868@2|Bacteria,1TU88@1239|Firmicutes,25871@186801|Clostridia,3WM3Q@541000|Ruminococcaceae	186801|Clostridia	J	Cysteine protease Prp	-	-	-	ko:K07584	-	-	-	-	ko00000	-	-	-	Peptidase_Prp
DEZH2_k127_6720392_5	1304284.L21TH_2119	9.118e-34	132.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,24MRS@186801|Clostridia,36JGP@31979|Clostridiaceae	186801|Clostridia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
DEZH2_k127_6720392_7	1042156.CXIVA_02840	7.948e-27	113.0	COG4922@1|root,COG4922@2|Bacteria,1VEC0@1239|Firmicutes,24JEI@186801|Clostridia,36PYK@31979|Clostridiaceae	186801|Clostridia	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
DEZH2_k127_6720392_0	644966.Tmar_1638	9.294e-186	593.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,3WCWS@538999|Clostridiales incertae sedis	186801|Clostridia	H	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
DEZH2_k127_6720392_6	1414720.CBYM010000025_gene2351	2.704e-32	128.0	COG2088@1|root,COG2088@2|Bacteria,1V9ZG@1239|Firmicutes,24MVQ@186801|Clostridia,36JKP@31979|Clostridiaceae	186801|Clostridia	D	Could be involved in septation	spoVG	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
DEZH2_k127_6720392_2	1392491.JIAE01000001_gene2053	3.285e-129	428.0	COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,2484K@186801|Clostridia,3WGQ1@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
DEZH2_k127_6748103_2	556261.HMPREF0240_00590	5.756e-51	184.0	COG1082@1|root,COG1082@2|Bacteria,1V9CF@1239|Firmicutes,24K6D@186801|Clostridia,36KZB@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6748103_0	1158607.UAU_04201	1.83e-176	558.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,4HAGN@91061|Bacilli,4B0Y2@81852|Enterococcaceae	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_6748103_3	931276.Cspa_c42870	2.271e-40	153.0	COG1082@1|root,COG1082@2|Bacteria,1V67Z@1239|Firmicutes,24HF6@186801|Clostridia,36W32@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6748103_1	931276.Cspa_c42880	6.579e-80	273.0	COG1082@1|root,COG1082@2|Bacteria,1UY4G@1239|Firmicutes,24CXG@186801|Clostridia,36W1Q@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_6748163_3	768710.DesyoDRAFT_4696	1.358e-73	260.0	COG2199@1|root,COG3706@2|Bacteria,1V2QN@1239|Firmicutes,249KZ@186801|Clostridia,264MJ@186807|Peptococcaceae	186801|Clostridia	T	TIGRFAM Diguanylate cyclase	-	-	2.7.7.65	ko:K18967	-	-	-	-	ko00000,ko01000,ko02000	9.B.34.1.1	-	-	5TM-5TMR_LYT,GGDEF
DEZH2_k127_6748163_4	203119.Cthe_1798	5.811e-71	246.0	COG2344@1|root,COG2344@2|Bacteria,1TSMR@1239|Firmicutes,247RQ@186801|Clostridia,3WHYJ@541000|Ruminococcaceae	186801|Clostridia	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
DEZH2_k127_6748163_5	1131462.DCF50_p1647	2.206e-47	173.0	COG1905@1|root,COG1905@2|Bacteria,1VBFB@1239|Firmicutes,24PJH@186801|Clostridia	186801|Clostridia	C	PFAM Respiratory-chain NADH dehydrogenase 24 Kd subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
DEZH2_k127_6748163_1	1131462.DCF50_p1648	6.78e-189	598.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,260R6@186807|Peptococcaceae	186801|Clostridia	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
DEZH2_k127_6748163_0	1131462.DCF50_p1649	1.658e-286	888.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,2610M@186807|Peptococcaceae	186801|Clostridia	C	iron hydrogenase, small subunit	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_9,NADH-G_4Fe-4S_3
DEZH2_k127_6748163_6	907931.AEIZ01000018_gene228	4.448e-07	60.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,4HIKU@91061|Bacilli,4AXPG@81850|Leuconostocaceae	91061|Bacilli	K	FR47-like protein	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
DEZH2_k127_6748163_2	931626.Awo_c04110	8.359e-90	301.0	COG2199@1|root,COG2202@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria,1UYXA@1239|Firmicutes	1239|Firmicutes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3
DEZH2_k127_6766576_1	632518.Calow_0325	4.303e-70	244.0	COG5512@1|root,COG5512@2|Bacteria,1TR27@1239|Firmicutes,247Z8@186801|Clostridia,42HVD@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF4038)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
DEZH2_k127_6766576_0	553973.CLOHYLEM_06000	9.82e-133	433.0	COG2407@1|root,COG2407@2|Bacteria,1TQDX@1239|Firmicutes,247N8@186801|Clostridia	186801|Clostridia	G	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Fucose_iso_C
DEZH2_k127_6789351_0	338966.Ppro_2997	2.13e-105	363.0	COG3322@1|root,COG5001@1|root,COG3322@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43U61@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	CHASE4 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,EAL,GGDEF,PAS,PAS_4,PAS_9,dCache_1
DEZH2_k127_6817996_2	580331.Thit_0428	2.089e-13	71.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,42GAF@68295|Thermoanaerobacterales	186801|Clostridia	K	helix-turn-helix- domain containing protein, AraC type	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
DEZH2_k127_6817996_0	1227352.C173_19171	2.215e-36	155.0	COG2972@1|root,COG2972@2|Bacteria,1U0TK@1239|Firmicutes,4HU03@91061|Bacilli,26V64@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
DEZH2_k127_6817996_1	1298598.JCM21714_2289	8.83e-17	85.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,4HC80@91061|Bacilli,4707P@74385|Gracilibacillus	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
DEZH2_k127_6817996_3	290402.Cbei_2657	4.511e-11	64.0	COG2207@1|root,COG2207@2|Bacteria,1TXIY@1239|Firmicutes,248D1@186801|Clostridia,36MIA@31979|Clostridiaceae	186801|Clostridia	K	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
DEZH2_k127_6833783_3	931276.Cspa_c43110	1.748e-16	80.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,36EVW@31979|Clostridiaceae	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
DEZH2_k127_6833783_2	189425.PGRAT_23515	1.024e-56	210.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1UICK@1239|Firmicutes,4ISPU@91061|Bacilli,27766@186822|Paenibacillaceae	91061|Bacilli	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
DEZH2_k127_6833783_0	1449050.JNLE01000003_gene1205	1.469e-231	722.0	COG2115@1|root,COG2115@2|Bacteria,1TQW2@1239|Firmicutes,24869@186801|Clostridia,36EXR@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the xylose isomerase family	xylA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08960	AP_endonuc_2
DEZH2_k127_6833783_1	97139.C824_01953	1.424e-58	205.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,36F3K@31979|Clostridiaceae	186801|Clostridia	G	Carbohydrate kinase, FGGY	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
DEZH2_k127_683965_3	755731.Clo1100_2094	2.425e-82	289.0	COG1323@1|root,COG1323@2|Bacteria,1TPP2@1239|Firmicutes,247UP@186801|Clostridia,36DM0@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0348 family	-	-	-	-	-	-	-	-	-	-	-	-	HIGH_NTase1
DEZH2_k127_683965_6	1045854.WKK_06545	5.027e-11	75.0	COG3405@1|root,COG3405@2|Bacteria,1V4ZT@1239|Firmicutes,4HG8R@91061|Bacilli	91061|Bacilli	G	Belongs to the glycosyl hydrolase 8 (cellulase D) family	ydaJ	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_8
DEZH2_k127_683965_5	1304284.L21TH_2303	3.265e-26	117.0	2C0MY@1|root,2ZC2Z@2|Bacteria,1V9XB@1239|Firmicutes,24PCF@186801|Clostridia,36J6H@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_683965_4	663278.Ethha_0660	4.92e-73	263.0	COG2206@1|root,COG2206@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,3WHPG@541000|Ruminococcaceae	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,Reg_prop
DEZH2_k127_683965_7	1321778.HMPREF1982_01165	1.443e-05	54.0	2BQJZ@1|root,32JG1@2|Bacteria,1UGMN@1239|Firmicutes,25P4F@186801|Clostridia,269UC@186813|unclassified Clostridiales	186801|Clostridia	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
DEZH2_k127_683965_2	509191.AEDB02000108_gene1637	1.266e-144	464.0	COG0280@1|root,COG0280@2|Bacteria,1TPQ0@1239|Firmicutes,247W9@186801|Clostridia,3WGX7@541000|Ruminococcaceae	186801|Clostridia	C	PFAM Phosphate acetyl butaryl transferase	pta	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
DEZH2_k127_683965_1	1408422.JHYF01000001_gene2935	1.85e-160	515.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,36EE0@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
DEZH2_k127_683965_0	1449050.JNLE01000003_gene290	1.894e-232	730.0	COG0441@1|root,COG0441@2|Bacteria,1UHT4@1239|Firmicutes,25E98@186801|Clostridia,36UJY@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
DEZH2_k127_6840250_3	573370.DMR_34220	7.598e-52	184.0	COG0753@1|root,COG0753@2|Bacteria,1MUXZ@1224|Proteobacteria,42MIN@68525|delta/epsilon subdivisions,2WJC5@28221|Deltaproteobacteria,2M91H@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the catalase family	katA	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
DEZH2_k127_6840250_1	1449335.JQLG01000004_gene349	9.527e-125	412.0	COG2133@1|root,COG2133@2|Bacteria,1TR38@1239|Firmicutes,4HBME@91061|Bacilli,27GU9@186828|Carnobacteriaceae	91061|Bacilli	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,GSDH,PKD,ThuA
DEZH2_k127_6840250_4	1123008.KB905701_gene2170	2.5e-44	165.0	COG2764@1|root,COG2764@2|Bacteria,4NQD7@976|Bacteroidetes,2FU3D@200643|Bacteroidia,22YFY@171551|Porphyromonadaceae	976|Bacteroidetes	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
DEZH2_k127_6840250_0	931626.Awo_c01810	7.108e-140	450.0	arCOG12964@1|root,2Z7HP@2|Bacteria,1UZIT@1239|Firmicutes,24G0N@186801|Clostridia,25YS8@186806|Eubacteriaceae	186801|Clostridia	S	Tocopherol cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Tocopherol_cycl
DEZH2_k127_6840250_2	1449343.JQLQ01000002_gene1976	3.01e-117	383.0	arCOG06481@1|root,2ZB4E@2|Bacteria,1V0ND@1239|Firmicutes,4HFG5@91061|Bacilli,27FK3@186828|Carnobacteriaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6865_1	318424.EU78_16965	2.665e-12	68.0	COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria,233VG@1762|Mycobacteriaceae	201174|Actinobacteria	K	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE
DEZH2_k127_6865_0	1444309.JAQG01000004_gene3613	2.284e-21	99.0	COG1961@1|root,COG1961@2|Bacteria,1TPUG@1239|Firmicutes,4HB3H@91061|Bacilli,26U6X@186822|Paenibacillaceae	91061|Bacilli	L	Recombinase zinc beta ribbon domain	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
DEZH2_k127_6869868_3	1035308.AQYY01000001_gene3504	2e-54	198.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,2608N@186807|Peptococcaceae	186801|Clostridia	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	2.3.1.40,6.2.1.20,6.2.1.3,6.2.1.48	ko:K01897,ko:K02182,ko:K05939	ko00061,ko00071,ko00564,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00564,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280,R01406,R04864	RC00004,RC00014,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
DEZH2_k127_6869868_1	484770.UFO1_0777	7.285e-108	353.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,4H42R@909932|Negativicutes	909932|Negativicutes	G	Class II Aldolase and Adducin N-terminal domain	araD	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
DEZH2_k127_6869868_0	720554.Clocl_0564	1.1e-151	492.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia,3WG8G@541000|Ruminococcaceae	186801|Clostridia	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
DEZH2_k127_6869868_4	1408424.JHYI01000030_gene4023	3.066e-51	190.0	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,4HH2N@91061|Bacilli,1ZCWR@1386|Bacillus	91061|Bacilli	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
DEZH2_k127_6869868_2	871968.DESME_09425	5.614e-63	217.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,248FH@186801|Clostridia,264IZ@186807|Peptococcaceae	186801|Clostridia	L	Nucleotidyltransferase DNA polymerase involved in DNA repair	-	-	-	ko:K03502	-	-	-	-	ko00000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
DEZH2_k127_6872235_1	1291050.JAGE01000001_gene653	1.305e-80	273.0	COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,3WH30@541000|Ruminococcaceae	186801|Clostridia	C	Hydrolyase, tartrate alpha subunit fumarate domain protein, Fe-S type	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
DEZH2_k127_6872235_4	398512.JQKC01000002_gene1949	2.769e-32	127.0	COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia,3WKJ9@541000|Ruminococcaceae	186801|Clostridia	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
DEZH2_k127_6872235_5	1507.HMPREF0262_01440	3.87e-17	84.0	COG1918@1|root,COG1918@2|Bacteria,1VEHC@1239|Firmicutes,24QKE@186801|Clostridia,36MTC@31979|Clostridiaceae	186801|Clostridia	P	ferrous iron transport protein	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
DEZH2_k127_6872235_0	1120746.CCNL01000010_gene1223	2.529e-165	539.0	COG0370@1|root,COG0370@2|Bacteria,2NNZ4@2323|unclassified Bacteria	2|Bacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
DEZH2_k127_6872235_3	699246.HMPREF0868_0674	2.825e-41	156.0	COG1321@1|root,COG1321@2|Bacteria,1V3IS@1239|Firmicutes,24MSE@186801|Clostridia	186801|Clostridia	K	iron dependent repressor	mntR_1	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repr_C,Fe_dep_repress
DEZH2_k127_6872235_2	180332.JTGN01000005_gene2817	1.043e-78	274.0	COG2211@1|root,COG2211@2|Bacteria,1URUG@1239|Firmicutes,248SK@186801|Clostridia	186801|Clostridia	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DEZH2_k127_689193_1	1392491.JIAE01000001_gene582	1.518e-46	172.0	COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,24824@186801|Clostridia,3WNGU@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF1732)	yicC	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
DEZH2_k127_689193_3	1007096.BAGW01000019_gene598	3.407e-26	111.0	COG2052@1|root,COG2052@2|Bacteria,1VA40@1239|Firmicutes,24MXV@186801|Clostridia,2N7KR@216572|Oscillospiraceae	186801|Clostridia	S	Domain of unknown function (DUF370)	NPD7_560	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
DEZH2_k127_689193_0	699246.HMPREF0868_1484	3.681e-68	237.0	COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia,2691D@186813|unclassified Clostridiales	186801|Clostridia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
DEZH2_k127_689193_2	699246.HMPREF0868_1483	1.59e-27	116.0	COG1758@1|root,COG1758@2|Bacteria	2|Bacteria	K	DNA-directed 5'-3' RNA polymerase activity	rpoZ	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
DEZH2_k127_6903933_0	365044.Pnap_3122	1.708e-247	764.0	COG0037@1|root,COG0037@2|Bacteria,1NKHX@1224|Proteobacteria,2VJ4Q@28216|Betaproteobacteria	28216|Betaproteobacteria	D	ATPase of the PP-loop superfamily implicated in cell cycle control	-	-	-	-	-	-	-	-	-	-	-	-	Asn_synthase
DEZH2_k127_6903933_1	365044.Pnap_3123	2.4e-144	459.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2VHY0@28216|Betaproteobacteria,4AA0X@80864|Comamonadaceae	28216|Betaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	-	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
DEZH2_k127_6903933_2	365044.Pnap_3124	3.192e-106	349.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,4AA2J@80864|Comamonadaceae	28216|Betaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	-	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
DEZH2_k127_6903933_3	365044.Pnap_3125	1.049e-21	94.0	COG2244@1|root,COG2244@2|Bacteria,1RC2S@1224|Proteobacteria,2VP5H@28216|Betaproteobacteria,4AAEF@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3
DEZH2_k127_6928809_0	699246.HMPREF0868_1328	1.831e-192	617.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,267N0@186813|unclassified Clostridiales	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
DEZH2_k127_6928809_3	699246.HMPREF0868_1321	3.573e-22	98.0	COG0268@1|root,COG0268@2|Bacteria	2|Bacteria	J	rRNA binding	rpsT	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
DEZH2_k127_6928809_2	1341157.RF007C_09990	1.239e-31	128.0	COG2314@1|root,COG2314@2|Bacteria,1VCD2@1239|Firmicutes,24H6T@186801|Clostridia,3WMIM@541000|Ruminococcaceae	186801|Clostridia	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	DZR,TM2,zinc_ribbon_2
DEZH2_k127_6928809_1	1410638.JHXJ01000004_gene1994	3.808e-176	560.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,3WHP7@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
DEZH2_k127_6935573_0	1410638.JHXJ01000013_gene2290	1.65e-268	844.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,3WGDZ@541000|Ruminococcaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
DEZH2_k127_6935573_4	479434.Sthe_0385	2.847e-62	229.0	COG0322@1|root,COG0758@1|root,COG0322@2|Bacteria,COG0758@2|Bacteria,2G5UA@200795|Chloroflexi,27XEI@189775|Thermomicrobia	189775|Thermomicrobia	LU	DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
DEZH2_k127_6935573_3	1121430.JMLG01000031_gene1635	5.078e-124	414.0	COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia,260SA@186807|Peptococcaceae	186801|Clostridia	O	PFAM magnesium chelatase	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
DEZH2_k127_6935573_1	1410638.JHXJ01000013_gene2286	2.261e-170	541.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,3WG9I@541000|Ruminococcaceae	186801|Clostridia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
DEZH2_k127_6935573_5	1392491.JIAE01000001_gene1140	5.845e-57	205.0	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,24GFQ@186801|Clostridia,3WJC8@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
DEZH2_k127_6935573_2	350688.Clos_1206	1.73e-158	525.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,36EWE@31979|Clostridiaceae	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
DEZH2_k127_6961788_3	720554.Clocl_2065	3.565e-08	57.0	COG5547@1|root,COG5547@2|Bacteria,1URQW@1239|Firmicutes,259MM@186801|Clostridia,3WQCN@541000|Ruminococcaceae	186801|Clostridia	S	Small integral membrane protein (DUF2273)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2273
DEZH2_k127_6961788_2	699246.HMPREF0868_1238	2.818e-39	153.0	COG1302@1|root,COG1302@2|Bacteria	2|Bacteria	M	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
DEZH2_k127_6961788_1	699246.HMPREF0868_1239	8.41e-41	154.0	COG1302@1|root,COG1302@2|Bacteria,1W1G6@1239|Firmicutes,253WZ@186801|Clostridia	186801|Clostridia	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
DEZH2_k127_6961788_0	699246.HMPREF0868_1240	4.955e-93	308.0	COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,249DV@186801|Clostridia,268CB@186813|unclassified Clostridiales	186801|Clostridia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
DEZH2_k127_6965873_4	1392491.JIAE01000001_gene1414	2.192e-38	148.0	COG0598@1|root,COG0598@2|Bacteria,1TPI8@1239|Firmicutes,24956@186801|Clostridia,3WGVT@541000|Ruminococcaceae	186801|Clostridia	P	Mg2 transporter protein CorA family protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
DEZH2_k127_6965873_2	1294142.CINTURNW_2982	8.6e-60	213.0	COG0756@1|root,COG0756@2|Bacteria,1V6HX@1239|Firmicutes,24K3X@186801|Clostridia,36IQU@31979|Clostridiaceae	186801|Clostridia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
DEZH2_k127_6965873_5	552398.HMPREF0866_01453	4.261e-19	100.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,3WH8K@541000|Ruminococcaceae	186801|Clostridia	O	Peptidase U32	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
DEZH2_k127_6965873_1	699246.HMPREF0868_1307	6.618e-102	344.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,267MR@186813|unclassified Clostridiales	186801|Clostridia	O	Collagenase	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
DEZH2_k127_6965873_7	999411.HMPREF1092_01165	9.158e-08	59.0	COG3027@1|root,COG3027@2|Bacteria,1VIXT@1239|Firmicutes,24RYN@186801|Clostridia,36ISE@31979|Clostridiaceae	186801|Clostridia	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
DEZH2_k127_6965873_0	935948.KE386495_gene1578	1.386e-270	842.0	COG1274@1|root,COG1274@2|Bacteria,1TQED@1239|Firmicutes,249NP@186801|Clostridia,42FYF@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
DEZH2_k127_6965873_3	1042163.BRLA_c000650	5.784e-59	215.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,4HA4R@91061|Bacilli,26QVV@186822|Paenibacillaceae	91061|Bacilli	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
DEZH2_k127_6965873_6	580327.Tthe_0109	2.103e-08	66.0	COG3583@1|root,COG3584@1|root,COG3583@2|Bacteria,COG3584@2|Bacteria,1TTIK@1239|Firmicutes,24997@186801|Clostridia,42ETJ@68295|Thermoanaerobacterales	186801|Clostridia	S	G5 domain protein	yabE	-	-	-	-	-	-	-	-	-	-	-	3D,DUF348,G5
DEZH2_k127_6972127_0	1392491.JIAE01000001_gene406	3.412e-147	480.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,3WGU5@541000|Ruminococcaceae	186801|Clostridia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
DEZH2_k127_6972127_1	720554.Clocl_0324	4.284e-62	219.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,3WIEP@541000|Ruminococcaceae	186801|Clostridia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
DEZH2_k127_6972127_2	1392491.JIAE01000001_gene408	3.199e-34	139.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,3WGVW@541000|Ruminococcaceae	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
DEZH2_k127_6985778_4	755731.Clo1100_0740	4.675e-41	156.0	COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,36UQ3@31979|Clostridiaceae	186801|Clostridia	I	long-chain acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
DEZH2_k127_6985778_5	697329.Rumal_1258	2.849e-40	160.0	COG2207@1|root,COG2207@2|Bacteria,1UX6U@1239|Firmicutes,25B1Q@186801|Clostridia,3WS9K@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18,HTH_AraC
DEZH2_k127_6985778_0	180332.JTGN01000003_gene2139	1.329e-229	732.0	COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,249UZ@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
DEZH2_k127_6985778_3	138119.DSY1728	3.593e-56	198.0	COG3682@1|root,COG3682@2|Bacteria,1V4WY@1239|Firmicutes,25D48@186801|Clostridia,262UD@186807|Peptococcaceae	186801|Clostridia	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
DEZH2_k127_6985778_2	1121335.Clst_0197	5.355e-172	556.0	COG4219@1|root,COG4219@2|Bacteria,1TP3Z@1239|Firmicutes,24A30@186801|Clostridia	186801|Clostridia	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
DEZH2_k127_6985778_6	228410.NE0267	4.292e-28	118.0	COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,2VSZQ@28216|Betaproteobacteria,374GP@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function (DUF1428)	ybaA	-	-	-	-	-	-	-	-	-	-	-	DUF1428
DEZH2_k127_6985778_1	309798.COPRO5265_0800	3.866e-176	595.0	COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,2491Y@186801|Clostridia,42F9N@68295|Thermoanaerobacterales	186801|Clostridia	F	5'-nucleotidase	-	-	3.1.3.5,3.1.3.6,3.1.4.16	ko:K01081,ko:K01119	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos,SH3_3,SLH
DEZH2_k127_6985778_8	929712.KI912613_gene3842	5.25e-06	50.0	COG0397@1|root,COG0397@2|Bacteria,2GNRX@201174|Actinobacteria,4CP7P@84995|Rubrobacteria	84995|Rubrobacteria	S	Uncharacterized ACR, YdiU/UPF0061 family	-	-	-	-	-	-	-	-	-	-	-	-	UPF0061
DEZH2_k127_6987309_0	1384057.CD33_06835	1.286e-129	419.0	COG4670@1|root,COG4670@2|Bacteria,1TQ4Z@1239|Firmicutes,4HDEN@91061|Bacilli	91061|Bacilli	I	Malonate decarboxylase, alpha subunit, transporter	mdcA	-	2.3.1.187	ko:K13929	-	-	R08944	RC00012,RC00014	ko00000,ko01000,ko02000	3.B.1.1.4	-	-	Mal_decarbox_Al
DEZH2_k127_6987309_1	536227.CcarbDRAFT_0885	1.851e-119	395.0	COG4799@1|root,COG4799@2|Bacteria,1TSPB@1239|Firmicutes	1239|Firmicutes	I	Malonate decarboxylase	mdcD	-	4.1.1.87	ko:K13932	-	-	-	-	ko00000,ko01000	-	-	-	Carboxyl_trans,MdcE
DEZH2_k127_7013008_0	1487921.DP68_18410	6.88e-294	914.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,36DJE@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
DEZH2_k127_7028532_9	1121937.AUHJ01000001_gene589	2.77e-22	101.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,1S98P@1236|Gammaproteobacteria,467XX@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
DEZH2_k127_7028532_10	398512.JQKC01000021_gene3731	3.371e-20	103.0	COG0791@1|root,COG0791@2|Bacteria,1V47C@1239|Firmicutes,24J59@186801|Clostridia,3WJTF@541000|Ruminococcaceae	186801|Clostridia	M	PFAM NlpC P60 family	-	-	3.4.14.13	ko:K20742	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	NLPC_P60,SH3_3
DEZH2_k127_7028532_11	1410638.JHXJ01000033_gene21	7.367e-20	91.0	COG0227@1|root,COG0227@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
DEZH2_k127_7028532_8	1410668.JNKC01000001_gene1999	1.153e-37	152.0	2DPU7@1|root,333E3@2|Bacteria,1VJIB@1239|Firmicutes,24RQU@186801|Clostridia,36NI8@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7028532_0	536227.CcarbDRAFT_3474	1.122e-140	456.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,36F1U@31979|Clostridiaceae	186801|Clostridia	C	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17,Fer4_9
DEZH2_k127_7028532_6	646529.Desaci_2464	2.787e-68	241.0	COG2162@1|root,COG2162@2|Bacteria,1V6M1@1239|Firmicutes,24G0C@186801|Clostridia,265XT@186807|Peptococcaceae	186801|Clostridia	Q	N-acetyltransferase	-	-	2.3.1.118	ko:K00675	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_2
DEZH2_k127_7028532_2	931626.Awo_c33800	9.564e-85	292.0	COG0407@1|root,COG0407@2|Bacteria,1V7V8@1239|Firmicutes,24M1I@186801|Clostridia,25YPS@186806|Eubacteriaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DEZH2_k127_7028532_1	1511.CLOST_0201	4.175e-137	443.0	COG0655@1|root,COG0655@2|Bacteria,1TQ8D@1239|Firmicutes,25CAN@186801|Clostridia	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DEZH2_k127_7028532_3	1069080.KB913028_gene259	5.458e-76	273.0	COG2199@1|root,COG2202@1|root,COG2203@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,4H568@909932|Negativicutes	909932|Negativicutes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9
DEZH2_k127_7028532_5	445335.CBN_1241	8.953e-70	246.0	COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,249J4@186801|Clostridia,36H6X@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
DEZH2_k127_7028532_7	35841.BT1A1_2244	4.659e-40	152.0	COG0295@1|root,COG0295@2|Bacteria,1V6IP@1239|Firmicutes,4HIJ3@91061|Bacilli,1ZG79@1386|Bacillus	91061|Bacilli	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006216,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009972,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042454,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	iYO844.BSU25300	dCMP_cyt_deam_1
DEZH2_k127_7028532_4	1195236.CTER_3161	8.166e-74	257.0	COG1297@1|root,COG1297@2|Bacteria,1TQJP@1239|Firmicutes,247JY@186801|Clostridia,3WHJB@541000|Ruminococcaceae	186801|Clostridia	S	oligopeptide transporter, OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
DEZH2_k127_7038616_2	398512.JQKC01000005_gene5387	3.793e-80	276.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,3WH0E@541000|Ruminococcaceae	186801|Clostridia	O	Trypsin-like serine proteases typically periplasmic contain C-terminal PDZ domain	degQ	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
DEZH2_k127_7038616_1	292459.STH3137	2.583e-107	360.0	COG1092@1|root,COG1092@2|Bacteria,1TRAJ@1239|Firmicutes,247TI@186801|Clostridia	186801|Clostridia	J	SMART PUA domain containing protein	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,PUA
DEZH2_k127_7038616_0	1120746.CCNL01000005_gene108	1.928e-173	553.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2NPG9@2323|unclassified Bacteria	2|Bacteria	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	cdr	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
DEZH2_k127_7048616_4	1392491.JIAE01000001_gene1317	0.0002316	45.0	COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,24J7Y@186801|Clostridia,3WK01@541000|Ruminococcaceae	186801|Clostridia	I	CDP-alcohol phosphatidyltransferase	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
DEZH2_k127_7048616_3	699246.HMPREF0868_0637	1.136e-28	116.0	COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,24QME@186801|Clostridia	186801|Clostridia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
DEZH2_k127_7048616_2	1392491.JIAE01000001_gene1319	1.793e-56	208.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,3WG7D@541000|Ruminococcaceae	186801|Clostridia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
DEZH2_k127_7048616_0	1291050.JAGE01000002_gene3833	1.257e-284	914.0	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia,3WH4V@541000|Ruminococcaceae	186801|Clostridia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
DEZH2_k127_7048616_1	1410638.JHXJ01000023_gene820	2.887e-70	243.0	COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia,3WGFT@541000|Ruminococcaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
DEZH2_k127_7062485_0	398512.JQKC01000008_gene996	2.86e-178	581.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,3WGTG@541000|Ruminococcaceae	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
DEZH2_k127_7062485_1	699246.HMPREF0868_0936	3.727e-122	398.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,267XE@186813|unclassified Clostridiales	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K02342,ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T
DEZH2_k127_7070124_1	1321778.HMPREF1982_04502	3.75e-116	377.0	COG0031@1|root,COG0031@2|Bacteria,1TZEW@1239|Firmicutes,249RW@186801|Clostridia,267P0@186813|unclassified Clostridiales	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
DEZH2_k127_7070124_0	748727.CLJU_c23800	1.81e-138	446.0	COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,2482W@186801|Clostridia,36DJX@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the carbamate kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS13830	AA_kinase
DEZH2_k127_7070124_2	511051.CSE_08970	7.439e-35	138.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DEZH2_k127_70731_4	1232443.BAIA02000110_gene2600	1.249e-41	161.0	COG2267@1|root,COG2267@2|Bacteria,1TRM1@1239|Firmicutes,247J5@186801|Clostridia,268F2@186813|unclassified Clostridiales	186801|Clostridia	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Peptidase_S9
DEZH2_k127_70731_1	1392491.JIAE01000001_gene1290	1.775e-173	550.0	COG0136@1|root,COG0136@2|Bacteria,1TPC6@1239|Firmicutes,248ZR@186801|Clostridia,3WGVU@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the aspartate-semialdehyde dehydrogenase family	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DEZH2_k127_70731_2	697281.Mahau_1395	1.443e-109	364.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,42F6S@68295|Thermoanaerobacterales	186801|Clostridia	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
DEZH2_k127_70731_3	411473.RUMCAL_00856	2.586e-74	262.0	COG1313@1|root,COG1313@2|Bacteria,1TRUV@1239|Firmicutes,247VW@186801|Clostridia,3WHUE@541000|Ruminococcaceae	186801|Clostridia	C	pyruvate formate lyase activating	PflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
DEZH2_k127_70731_0	1392491.JIAE01000001_gene1274	1.571e-175	563.0	COG1362@1|root,COG1362@2|Bacteria,1TP6G@1239|Firmicutes,2486Y@186801|Clostridia,3WHAH@541000|Ruminococcaceae	186801|Clostridia	E	M18 family aminopeptidase	apeA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M18
DEZH2_k127_70731_5	553973.CLOHYLEM_06789	3.423e-17	85.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,21ZMQ@1506553|Lachnoclostridium	186801|Clostridia	E	histidinol phosphate phosphatase HisJ family	hisK	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
DEZH2_k127_7078650_1	1123376.AUIU01000017_gene94	5.564e-109	356.0	COG0798@1|root,COG0798@2|Bacteria,3J0XN@40117|Nitrospirae	40117|Nitrospirae	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
DEZH2_k127_7078650_0	768706.Desor_2641	2.128e-157	501.0	COG0701@1|root,COG0701@2|Bacteria,1TQC7@1239|Firmicutes,24A02@186801|Clostridia,2614E@186807|Peptococcaceae	186801|Clostridia	S	permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
DEZH2_k127_7078650_3	883110.HMPREF9260_01103	1.094e-30	123.0	COG0640@1|root,COG0640@2|Bacteria,1VEER@1239|Firmicutes,4HPIB@91061|Bacilli	91061|Bacilli	K	arsenical resistance operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
DEZH2_k127_7078650_2	41431.PCC8801_0690	6.198e-47	171.0	COG1819@1|root,COG1819@2|Bacteria,1G036@1117|Cyanobacteria,3KIRB@43988|Cyanothece	1117|Cyanobacteria	CG	glycosyl transferase family 28	-	-	2.4.1.173	ko:K05841	-	-	-	-	ko00000,ko01000,ko01003	-	GT1	-	Glyco_transf_28,UDPGT
DEZH2_k127_7079388_2	1280673.AUJJ01000003_gene106	3.916e-05	48.0	COG4813@1|root,COG4813@2|Bacteria,1TPZ1@1239|Firmicutes,24EF0@186801|Clostridia,4BXZM@830|Butyrivibrio	186801|Clostridia	G	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
DEZH2_k127_7079388_0	935837.JAEK01000016_gene1312	8.293e-187	592.0	COG4099@1|root,COG4099@2|Bacteria,1TRER@1239|Firmicutes,4HE5Z@91061|Bacilli	91061|Bacilli	S	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Peptidase_S9
DEZH2_k127_7079388_1	357809.Cphy_0937	3.917e-62	216.0	COG0488@1|root,COG0488@2|Bacteria,1TSB8@1239|Firmicutes,248XT@186801|Clostridia,21ZPC@1506553|Lachnoclostridium	186801|Clostridia	S	ATPases associated with a variety of cellular activities	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
DEZH2_k127_7085516_13	1487923.DP73_01115	2.318e-22	110.0	COG2508@1|root,COG2508@2|Bacteria,1TRRH@1239|Firmicutes,24C6R@186801|Clostridia	186801|Clostridia	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30,PucR
DEZH2_k127_7085516_14	1485543.JMME01000003_gene2015	8.706e-09	68.0	COG0070@1|root,COG0493@1|root,COG1142@1|root,COG0070@2|Bacteria,COG0493@2|Bacteria,COG1142@2|Bacteria,1TQC4@1239|Firmicutes,4H1YM@909932|Negativicutes	909932|Negativicutes	C	GXGXG motif	preT	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Fer4_9,GXGXG,Pyr_redox_2
DEZH2_k127_7085516_11	1294142.CINTURNW_4027	1.028e-36	158.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,36UQE@31979|Clostridiaceae	186801|Clostridia	C	FAD dependent oxidoreductase	-	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FMN_bind
DEZH2_k127_7085516_12	391735.Veis_4964	2.563e-31	141.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,4AD2N@80864|Comamonadaceae	28216|Betaproteobacteria	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
DEZH2_k127_7085516_5	1382306.JNIM01000001_gene1272	4.57e-108	359.0	COG0444@1|root,COG0444@2|Bacteria,2G5PT@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
DEZH2_k127_7085516_3	1128421.JAGA01000002_gene834	2.872e-122	403.0	COG4608@1|root,COG4608@2|Bacteria,2NP9Y@2323|unclassified Bacteria	2|Bacteria	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
DEZH2_k127_7085516_7	1038860.AXAP01000005_gene8108	1.746e-77	271.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,3JUIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
DEZH2_k127_7085516_8	196490.AUEZ01000005_gene3557	1.156e-69	247.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VF5U@28211|Alphaproteobacteria,3JXA1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
DEZH2_k127_7085516_2	1042156.CXIVA_05990	6.104e-144	466.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,36E3Q@31979|Clostridiaceae	186801|Clostridia	E	Dehydrogenase	-	-	1.1.1.1,1.1.1.14,1.1.1.284	ko:K00008,ko:K00121	ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	M00014	R00623,R00754,R00875,R01896,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00085,RC00087,RC00088,RC00099,RC00102,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
DEZH2_k127_7085516_9	1396.DJ87_4296	5.276e-68	246.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,1ZDDG@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_2,PUCC,Sugar_tr
DEZH2_k127_7085516_4	1196322.A370_00999	7.937e-120	390.0	COG2326@1|root,COG2326@2|Bacteria,1TQQR@1239|Firmicutes,249HE@186801|Clostridia,36FGK@31979|Clostridiaceae	186801|Clostridia	S	TIGRFAM polyphosphate nucleotide phosphotransferase, PPK2 family	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
DEZH2_k127_7085516_10	1121024.AUCD01000087_gene1045	3.237e-43	173.0	COG2062@1|root,COG5607@1|root,COG2062@2|Bacteria,COG5607@2|Bacteria,1U4WX@1239|Firmicutes,4IFE0@91061|Bacilli,27HFX@186828|Carnobacteriaceae	91061|Bacilli	T	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
DEZH2_k127_7085516_1	1304284.L21TH_0598	1.466e-154	503.0	COG0248@1|root,COG0248@2|Bacteria,1TS3I@1239|Firmicutes,248EW@186801|Clostridia,36FHQ@31979|Clostridiaceae	186801|Clostridia	FP	Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
DEZH2_k127_7085516_0	483218.BACPEC_02154	3.723e-239	755.0	COG0855@1|root,COG0855@2|Bacteria,1TNZM@1239|Firmicutes,248XY@186801|Clostridia,26A3S@186813|unclassified Clostridiales	186801|Clostridia	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
DEZH2_k127_7114965_0	1121335.Clst_0657	4.84e-75	257.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,2494X@186801|Clostridia,3WIGS@541000|Ruminococcaceae	186801|Clostridia	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
DEZH2_k127_7114965_1	720554.Clocl_0107	3.226e-69	242.0	COG1394@1|root,COG1394@2|Bacteria,1TQ1Y@1239|Firmicutes,247TC@186801|Clostridia,3WHIG@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
DEZH2_k127_712472_1	1038867.AXAY01000031_gene4203	1.737e-80	274.0	COG0639@1|root,COG0639@2|Bacteria,1MUV1@1224|Proteobacteria,2V74D@28211|Alphaproteobacteria,3K3QZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
DEZH2_k127_712472_0	526222.Desal_3605	1.414e-107	357.0	COG0458@1|root,COG0458@2|Bacteria,1RJ88@1224|Proteobacteria,42UEM@68525|delta/epsilon subdivisions,2WREA@28221|Deltaproteobacteria,2MHE0@213115|Desulfovibrionales	28221|Deltaproteobacteria	EF	ATP-grasp domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_3
DEZH2_k127_712472_2	1120746.CCNL01000014_gene2165	1.608e-24	107.0	COG0028@1|root,COG0028@2|Bacteria,2NNMW@2323|unclassified Bacteria	2|Bacteria	EH	thiamine pyrophosphate protein TPP binding domain protein	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
DEZH2_k127_7131930_0	306281.AJLK01000065_gene5420	9.501e-77	271.0	COG1503@1|root,COG1503@2|Bacteria,1G29A@1117|Cyanobacteria,1JI27@1189|Stigonemataceae	1117|Cyanobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7131930_1	1195236.CTER_0036	2.142e-09	59.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,3WGK9@541000|Ruminococcaceae	186801|Clostridia	G	Glycosyltransferase family 36	ndvB	-	-	-	-	-	-	-	-	-	-	-	DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase
DEZH2_k127_7134013_0	1042156.CXIVA_00510	0.0	1345.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,36M9Q@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
DEZH2_k127_7134013_1	748727.CLJU_c25450	1.232e-101	333.0	COG0437@1|root,COG0437@2|Bacteria,1V35R@1239|Firmicutes,24GWA@186801|Clostridia,36HJE@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	ko:K07307,ko:K08358	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R09501,R10150	RC02555,RC03109	ko00000,ko00001,ko02000	5.A.3.10,5.A.3.3	-	-	Fer4_11,Fer4_3,Fer4_4,Fer4_7
DEZH2_k127_7134013_3	748727.CLJU_c25460	4.622e-53	196.0	COG3381@1|root,COG3381@2|Bacteria,1VE7Q@1239|Firmicutes,25DPP@186801|Clostridia	186801|Clostridia	S	PFAM Nitrate reductase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
DEZH2_k127_7134013_2	748727.CLJU_c25470	2.64e-85	287.0	COG0479@1|root,COG0479@2|Bacteria,1TP8R@1239|Firmicutes,247QI@186801|Clostridia,36E7Z@31979|Clostridiaceae	186801|Clostridia	C	Sulfite reductase, subunit A	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
DEZH2_k127_7135963_0	1392491.JIAE01000001_gene1942	1.793e-37	159.0	28YI5@1|root,2ZKC3@2|Bacteria,1W58K@1239|Firmicutes,2557E@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7142511_1	1256908.HMPREF0373_01015	1.454e-57	214.0	COG1802@1|root,COG1802@2|Bacteria,1UFW1@1239|Firmicutes,25MUQ@186801|Clostridia,25Z4W@186806|Eubacteriaceae	186801|Clostridia	K	FCD domain	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
DEZH2_k127_7142511_0	748727.CLJU_c25440	2.119e-78	265.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,36M9Q@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
DEZH2_k127_7159902_0	445972.ANACOL_04416	2.776e-62	217.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,3WGKC@541000|Ruminococcaceae	186801|Clostridia	C	Electron transfer flavoprotein FAD-binding domain	etfA	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha
DEZH2_k127_7159902_1	658086.HMPREF0994_05386	3.655e-50	182.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,27IGM@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Electron transfer flavoprotein FAD-binding domain	etfA	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha
DEZH2_k127_7159902_2	272562.CA_C2560	1.837e-39	151.0	COG0454@1|root,COG0456@2|Bacteria,1VBAE@1239|Firmicutes,24N72@186801|Clostridia,36IGV@31979|Clostridiaceae	186801|Clostridia	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DEZH2_k127_7159902_3	521460.Athe_0359	5.674e-15	78.0	COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,1TQH8@1239|Firmicutes,2491Q@186801|Clostridia,42EU7@68295|Thermoanaerobacterales	186801|Clostridia	S	Extradiol ring-cleavage dioxygenase, class III	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
DEZH2_k127_7187399_3	1211819.CALK01000009_gene2710	1.99e-30	126.0	COG1989@1|root,COG1989@2|Bacteria,1V91J@1239|Firmicutes,3VUQK@526524|Erysipelotrichia	526524|Erysipelotrichia	NOU	Bacterial Peptidase A24 N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DiS_P_DiS,Peptidase_A24
DEZH2_k127_7187399_0	1291050.JAGE01000001_gene2164	1.188e-123	411.0	COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia,3WGS8@541000|Ruminococcaceae	186801|Clostridia	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
DEZH2_k127_7187399_1	720554.Clocl_0671	8.543e-92	306.0	COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,247QY@186801|Clostridia,3WGQP@541000|Ruminococcaceae	186801|Clostridia	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
DEZH2_k127_7187399_2	1089548.KI783301_gene1937	4.354e-45	168.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,4H9U4@91061|Bacilli,3WEH5@539002|Bacillales incertae sedis	91061|Bacilli	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
DEZH2_k127_7211455_0	1410670.JHXF01000006_gene1168	1.738e-130	427.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,3WGE4@541000|Ruminococcaceae	186801|Clostridia	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
DEZH2_k127_7211455_1	903814.ELI_4405	2.902e-130	430.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,25UTB@186806|Eubacteriaceae	186801|Clostridia	V	ABC-type multidrug transport system, ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DEZH2_k127_7220903_15	931626.Awo_c16070	2.052e-07	55.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,24B5A@186801|Clostridia,25WE9@186806|Eubacteriaceae	186801|Clostridia	C	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
DEZH2_k127_7220903_2	1256908.HMPREF0373_02629	1.211e-135	440.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,25V4V@186806|Eubacteriaceae	186801|Clostridia	C	Acetokinase family	buk	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
DEZH2_k127_7220903_10	1304874.JAFY01000002_gene167	1.357e-71	246.0	COG1014@1|root,COG1014@2|Bacteria,3TANM@508458|Synergistetes	508458|Synergistetes	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
DEZH2_k127_7220903_1	1304874.JAFY01000002_gene168	1.814e-244	767.0	COG4231@1|root,COG4231@2|Bacteria,3T9PR@508458|Synergistetes	508458|Synergistetes	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
DEZH2_k127_7220903_13	1476973.JMMB01000007_gene2518	9.97e-26	107.0	COG4895@1|root,COG4895@2|Bacteria,1VEG3@1239|Firmicutes,24QNU@186801|Clostridia,25TX7@186804|Peptostreptococcaceae	186801|Clostridia	S	Uncharacterized conserved protein (DUF2196)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2196
DEZH2_k127_7220903_11	1408422.JHYF01000006_gene1154	1.53e-66	236.0	COG0778@1|root,COG0778@2|Bacteria,1V0NJ@1239|Firmicutes,24FM7@186801|Clostridia,36EJ6@31979|Clostridiaceae	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
DEZH2_k127_7220903_6	1423806.JCM15457_477	1.187e-86	295.0	COG0657@1|root,COG0657@2|Bacteria,1V212@1239|Firmicutes,4HESD@91061|Bacilli,3FBGQ@33958|Lactobacillaceae	91061|Bacilli	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
DEZH2_k127_7220903_0	913865.DOT_4541	3.661e-275	859.0	COG4147@1|root,COG4147@2|Bacteria,1UHT5@1239|Firmicutes,24G6E@186801|Clostridia,261GM@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
DEZH2_k127_7220903_14	913865.DOT_4540	9.93e-23	101.0	2DQ0U@1|root,3349F@2|Bacteria	2|Bacteria	S	Protein of unknown function, DUF485	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
DEZH2_k127_7220903_8	1123511.KB905875_gene1868	4.627e-75	268.0	COG0793@1|root,COG0793@2|Bacteria,1UYV5@1239|Firmicutes	1239|Firmicutes	M	Belongs to the peptidase S41A family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
DEZH2_k127_7220903_4	1232453.BAIF02000023_gene4392	9.632e-105	347.0	COG0395@1|root,COG0395@2|Bacteria,1TP1G@1239|Firmicutes,24BAS@186801|Clostridia	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
DEZH2_k127_7220903_3	1226325.HMPREF1548_06634	1.407e-123	404.0	COG4209@1|root,COG4209@2|Bacteria,1TQFY@1239|Firmicutes,24923@186801|Clostridia,36F9W@31979|Clostridiaceae	186801|Clostridia	G	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
DEZH2_k127_7220903_5	1232453.BAIF02000023_gene4390	9.514e-90	316.0	COG1653@1|root,COG1653@2|Bacteria,1W1JU@1239|Firmicutes,24KGG@186801|Clostridia	186801|Clostridia	G	Domain of unknown function (DUF3502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3502,SBP_bac_1
DEZH2_k127_7220903_7	180332.JTGN01000020_gene1229	1.898e-78	270.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V8U9@1239|Firmicutes,24J0N@186801|Clostridia	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC,Response_reg
DEZH2_k127_7220903_9	1226325.HMPREF1548_06632	5.425e-73	268.0	COG2972@1|root,COG2972@2|Bacteria,1U6WN@1239|Firmicutes,24CTB@186801|Clostridia,36RKJ@31979|Clostridiaceae	186801|Clostridia	T	K07718 two-component system, sensor histidine kinase YesM	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
DEZH2_k127_7220903_12	177437.HRM2_17470	1.151e-39	150.0	COG3370@1|root,COG3370@2|Bacteria,1N27G@1224|Proteobacteria,42TID@68525|delta/epsilon subdivisions,2X5QM@28221|Deltaproteobacteria,2MM1R@213118|Desulfobacterales	28221|Deltaproteobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
DEZH2_k127_7272622_2	153948.NAL212_1434	8.438e-10	61.0	28HIF@1|root,2Z7TX@2|Bacteria,1MY24@1224|Proteobacteria,2VM3H@28216|Betaproteobacteria,37400@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Bacteriophage replication gene A protein (GPA)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPA
DEZH2_k127_7272622_1	1219077.VAZ01S_024_00260	6.079e-12	70.0	COG2963@1|root,COG2963@2|Bacteria,1N1HQ@1224|Proteobacteria,1SBAR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
DEZH2_k127_7272622_0	153948.NAL212_1263	7.904e-251	774.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,373E2@32003|Nitrosomonadales	28216|Betaproteobacteria	L	PFAM Integrase, catalytic core	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
DEZH2_k127_7282472_4	278963.ATWD01000001_gene1385	5.359e-13	77.0	COG4773@1|root,COG4773@2|Bacteria,3Y9AC@57723|Acidobacteria,2JP64@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
DEZH2_k127_7282472_0	1094980.Mpsy_0305	8.728e-171	545.0	COG0535@1|root,arCOG00940@2157|Archaea,2XV7M@28890|Euryarchaeota,2N94R@224756|Methanomicrobia	224756|Methanomicrobia	S	Radical SAM domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DEZH2_k127_7282472_3	1304880.JAGB01000001_gene418	4.222e-51	190.0	COG2949@1|root,COG2949@2|Bacteria,1V1FP@1239|Firmicutes,24HBG@186801|Clostridia	186801|Clostridia	S	DUF218 domain	-	-	-	ko:K03748	-	-	-	-	ko00000	-	-	-	DUF218
DEZH2_k127_7282472_1	398512.JQKC01000013_gene1408	2.15e-154	522.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,3WNSP@541000|Ruminococcaceae	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
DEZH2_k127_7282472_2	370438.PTH_0226	9.944e-90	305.0	COG0157@1|root,COG0157@2|Bacteria,1TPQC@1239|Firmicutes,248P2@186801|Clostridia,26046@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12010	QRPTase_C,QRPTase_N
DEZH2_k127_7335391_1	935948.KE386495_gene1661	6.25e-70	243.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,42F49@68295|Thermoanaerobacterales	186801|Clostridia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
DEZH2_k127_7335391_0	720554.Clocl_0002	7.366e-122	402.0	COG0592@1|root,COG0592@2|Bacteria,1TQ7J@1239|Firmicutes,248EG@186801|Clostridia,3WGZ2@541000|Ruminococcaceae	186801|Clostridia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
DEZH2_k127_7335391_2	699246.HMPREF0868_0091	2.01e-16	79.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia,268Q0@186813|unclassified Clostridiales	186801|Clostridia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
DEZH2_k127_7336832_0	290402.Cbei_4206	2.997e-58	203.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,36DYK@31979|Clostridiaceae	186801|Clostridia	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
DEZH2_k127_7336832_1	1304880.JAGB01000002_gene1966	1.293e-51	185.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia	186801|Clostridia	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
DEZH2_k127_7336832_2	1304880.JAGB01000002_gene1969	0.000135	51.0	COG3707@1|root,COG3707@2|Bacteria,1U6TA@1239|Firmicutes,24G9P@186801|Clostridia	186801|Clostridia	T	response regulator receiver	-	-	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
DEZH2_k127_7354611_0	545695.TREAZ_2900	3.297e-140	456.0	COG1482@1|root,COG1482@2|Bacteria	2|Bacteria	G	cell wall glycoprotein biosynthetic process	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
DEZH2_k127_7354611_1	180332.JTGN01000017_gene135	1.541e-81	284.0	COG1070@1|root,COG1070@2|Bacteria,1UYIG@1239|Firmicutes,24C21@186801|Clostridia	186801|Clostridia	G	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
DEZH2_k127_7355071_6	1392491.JIAE01000001_gene1359	7.364e-16	80.0	COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia,3WIM6@541000|Ruminococcaceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
DEZH2_k127_7355071_1	1392491.JIAE01000001_gene1360	7.249e-151	484.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,3WMVT@541000|Ruminococcaceae	186801|Clostridia	L	Holliday junction DNA helicase ruvB C-terminus	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
DEZH2_k127_7355071_5	588581.Cpap_3497	2.507e-39	153.0	COG1636@1|root,COG1636@2|Bacteria,1TT7H@1239|Firmicutes,248EA@186801|Clostridia,3WGWP@541000|Ruminococcaceae	186801|Clostridia	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
DEZH2_k127_7355071_3	398512.JQKC01000008_gene981	2.323e-131	442.0	COG1293@1|root,COG1293@2|Bacteria,1TQ8A@1239|Firmicutes,248RK@186801|Clostridia,3WG7T@541000|Ruminococcaceae	186801|Clostridia	K	Fibronectin-binding protein	FbpA	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
DEZH2_k127_7355071_2	1304880.JAGB01000002_gene1871	7.58e-149	482.0	COG1883@1|root,COG1883@2|Bacteria,1TPEP@1239|Firmicutes,248ET@186801|Clostridia	186801|Clostridia	C	decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
DEZH2_k127_7355071_0	1410638.JHXJ01000010_gene146	1.429e-194	613.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,3WGVK@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the ribose-phosphate pyrophosphokinase family	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
DEZH2_k127_7355071_4	1410638.JHXJ01000010_gene146	1.528e-76	261.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,3WGVK@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the ribose-phosphate pyrophosphokinase family	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
DEZH2_k127_7355819_0	261292.Nit79A3_2249	0.0	1003.0	COG3039@1|root,COG3039@2|Bacteria,1Q9GN@1224|Proteobacteria,2WCRD@28216|Betaproteobacteria,373TB@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF772
DEZH2_k127_7355819_1	56107.Cylst_3877	1.471e-16	81.0	28IH6@1|root,2Z8IF@2|Bacteria,1G1B5@1117|Cyanobacteria,1HKZI@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7368673_6	699246.HMPREF0868_1047	1.482e-11	66.0	COG1994@1|root,COG1994@2|Bacteria,1V6D4@1239|Firmicutes,24K0D@186801|Clostridia,268X3@186813|unclassified Clostridiales	186801|Clostridia	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
DEZH2_k127_7368673_0	203119.Cthe_0686	1.092e-153	491.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia,3WGS4@541000|Ruminococcaceae	186801|Clostridia	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
DEZH2_k127_7368673_3	1392491.JIAE01000001_gene1536	1.469e-73	256.0	COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,249VW@186801|Clostridia,3WJM6@541000|Ruminococcaceae	186801|Clostridia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
DEZH2_k127_7368673_4	1392491.JIAE01000001_gene1535	1.39e-64	230.0	COG1386@1|root,COG1386@2|Bacteria,1V6HI@1239|Firmicutes,24JW7@186801|Clostridia,3WJD2@541000|Ruminococcaceae	186801|Clostridia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
DEZH2_k127_7368673_2	720554.Clocl_1496	1.623e-122	409.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,247WG@186801|Clostridia,3WH24@541000|Ruminococcaceae	186801|Clostridia	I	Carboxyl transferase domain	yqjD	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
DEZH2_k127_7368673_5	509191.AEDB02000003_gene1108	1.147e-32	132.0	COG4770@1|root,COG4770@2|Bacteria,1VA1E@1239|Firmicutes,24MUJ@186801|Clostridia,3WK2X@541000|Ruminococcaceae	186801|Clostridia	I	Biotin-requiring enzyme	gcdC	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
DEZH2_k127_7368673_1	720554.Clocl_1499	5.475e-147	469.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,3WH2N@541000|Ruminococcaceae	186801|Clostridia	C	Pyruvate carboxylase, C-terminal domain subunit K01960	oadA	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
DEZH2_k127_739097_0	240302.BN982_02920	1.953e-113	379.0	COG0397@1|root,COG0397@2|Bacteria,1TQXD@1239|Firmicutes,4HBKH@91061|Bacilli,3NDAP@45667|Halobacillus	91061|Bacilli	S	Uncharacterized ACR, YdiU/UPF0061 family	-	-	-	-	-	-	-	-	-	-	-	-	UPF0061
DEZH2_k127_739097_1	397288.C806_03394	1.123e-94	316.0	COG0673@1|root,COG0673@2|Bacteria,1TQSS@1239|Firmicutes,249QZ@186801|Clostridia,27ITG@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	ko:K22230	ko00562,ko01120,map00562,map01120	-	R09954	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA
DEZH2_k127_7430228_0	1069080.KB913028_gene1278	9.932e-241	747.0	COG0753@1|root,COG0753@2|Bacteria,1TPPV@1239|Firmicutes,4H3D9@909932|Negativicutes	909932|Negativicutes	C	Belongs to the catalase family	-	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
DEZH2_k127_7430228_2	1410638.JHXJ01000005_gene2138	1.588e-75	263.0	COG3752@1|root,COG3752@2|Bacteria,1V0FI@1239|Firmicutes,24GQX@186801|Clostridia	186801|Clostridia	S	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
DEZH2_k127_7430228_1	445971.ANASTE_00757	1.303e-78	274.0	COG0463@1|root,COG0463@2|Bacteria,1TQ8C@1239|Firmicutes,248MK@186801|Clostridia,25W8N@186806|Eubacteriaceae	186801|Clostridia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
DEZH2_k127_7430228_3	1131462.DCF50_p2925	9.279e-44	166.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,260C9@186807|Peptococcaceae	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	-	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SecA_DEAD,SecA_PP_bind,SecA_SW
DEZH2_k127_7446837_1	1195236.CTER_0545	4.108e-55	198.0	COG0436@1|root,COG0436@2|Bacteria,1TP36@1239|Firmicutes,248ZV@186801|Clostridia,3WH96@541000|Ruminococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	yhdR	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
DEZH2_k127_7446837_0	699246.HMPREF0868_1315	8.942e-71	244.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,268BM@186813|unclassified Clostridiales	186801|Clostridia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
DEZH2_k127_7446837_5	1392491.JIAE01000001_gene1791	6.946e-18	84.0	COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia,3WKXA@541000|Ruminococcaceae	186801|Clostridia	J	Ribosomal protein L35	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
DEZH2_k127_7446837_2	1410638.JHXJ01000002_gene1270	1.89e-47	172.0	COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia,3WIYY@541000|Ruminococcaceae	186801|Clostridia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
DEZH2_k127_7446837_3	1392491.JIAE01000001_gene1787	5.737e-42	164.0	COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,248DV@186801|Clostridia,3WIQ9@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
DEZH2_k127_7446837_4	509191.AEDB02000065_gene730	1.645e-36	141.0	COG0569@1|root,COG0569@2|Bacteria,1V2ZF@1239|Firmicutes,24GNX@186801|Clostridia,3WIPU@541000|Ruminococcaceae	186801|Clostridia	C	TrkA N-terminal domain protein	trkA2	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_N
DEZH2_k127_7449853_2	768704.Desmer_3534	1.954e-39	154.0	COG3682@1|root,COG3682@2|Bacteria,1V7DH@1239|Firmicutes,24JAQ@186801|Clostridia,265HR@186807|Peptococcaceae	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
DEZH2_k127_7449853_0	768704.Desmer_3535	5.249e-113	372.0	COG4219@1|root,COG4219@2|Bacteria,1UXWF@1239|Firmicutes,248KW@186801|Clostridia,2643I@186807|Peptococcaceae	186801|Clostridia	KT	Antirepressor regulating drug resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
DEZH2_k127_7449853_3	1378168.N510_00426	1.486e-31	138.0	2DNG5@1|root,32XBR@2|Bacteria,1V8W9@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LprI
DEZH2_k127_7449853_1	1286171.EAL2_c21710	5.321e-54	190.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,25UZK@186806|Eubacteriaceae	186801|Clostridia	O	Peptidase, U32 family	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
DEZH2_k127_748249_0	699246.HMPREF0868_0196	0.0	1015.0	COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,267JY@186813|unclassified Clostridiales	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
DEZH2_k127_748249_1	1487921.DP68_16340	1.024e-14	78.0	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,24QK6@186801|Clostridia,36MPM@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
DEZH2_k127_7487752_3	457570.Nther_0094	3.385e-08	57.0	COG0857@1|root,COG0857@2|Bacteria,1VEWN@1239|Firmicutes,24QW9@186801|Clostridia	186801|Clostridia	C	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
DEZH2_k127_7487752_0	1195236.CTER_2553	1.181e-131	433.0	COG2000@1|root,COG2221@1|root,COG4624@1|root,COG2000@2|Bacteria,COG2221@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,24BF5@186801|Clostridia,3WGD2@541000|Ruminococcaceae	186801|Clostridia	C	Iron only hydrogenase large subunit, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,Fer4_9
DEZH2_k127_7487752_1	411467.BACCAP_02755	1.019e-45	168.0	COG2172@1|root,COG2172@2|Bacteria,1V6YP@1239|Firmicutes,24JJ0@186801|Clostridia,2691A@186813|unclassified Clostridiales	186801|Clostridia	T	Histidine kinase-like ATPase domain	RsbW	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2
DEZH2_k127_7487752_2	398512.JQKC01000016_gene2854	1.085e-35	139.0	COG4109@1|root,COG4109@2|Bacteria,1VA3T@1239|Firmicutes,24MQM@186801|Clostridia,3WJAV@541000|Ruminococcaceae	186801|Clostridia	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
DEZH2_k127_7505587_0	1121324.CLIT_2c03680	2.081e-47	177.0	COG3434@1|root,COG3434@2|Bacteria,1TPWC@1239|Firmicutes,248M1@186801|Clostridia,25TG5@186804|Peptostreptococcaceae	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,HDOD
DEZH2_k127_7505587_2	994573.T472_0204080	3.585e-15	81.0	2E4E5@1|root,32Z9D@2|Bacteria,1VZM0@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7505587_1	1410638.JHXJ01000027_gene1164	2.991e-43	161.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,3WIX7@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
DEZH2_k127_7509442_2	699246.HMPREF0868_1176	8.581e-122	398.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,2684D@186813|unclassified Clostridiales	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
DEZH2_k127_7509442_11	857293.CAAU_0186	5.176e-38	143.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia,36KP2@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
DEZH2_k127_7509442_12	1392491.JIAE01000001_gene1434	3.782e-18	87.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,3WKWP@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
DEZH2_k127_7509442_10	720554.Clocl_1762	1.564e-38	152.0	COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia,3WIMH@541000|Ruminococcaceae	186801|Clostridia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
DEZH2_k127_7509442_4	1392491.JIAE01000001_gene1432	2.637e-92	310.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,247JF@186801|Clostridia,3WH8Z@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
DEZH2_k127_7509442_7	699246.HMPREF0868_1171	2.337e-52	188.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia,2693H@186813|unclassified Clostridiales	186801|Clostridia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
DEZH2_k127_7509442_5	203119.Cthe_0763	9.286e-88	298.0	COG1161@1|root,COG1161@2|Bacteria,1TQGK@1239|Firmicutes,2490H@186801|Clostridia,3WGB7@541000|Ruminococcaceae	186801|Clostridia	S	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity	ylqF	-	-	ko:K14540	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1
DEZH2_k127_7509442_6	913865.DOT_3485	6.363e-63	224.0	COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,248IT@186801|Clostridia,261GI@186807|Peptococcaceae	186801|Clostridia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
DEZH2_k127_7509442_13	591001.Acfer_0476	1.223e-07	60.0	COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,4H5MB@909932|Negativicutes	909932|Negativicutes	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
DEZH2_k127_7509442_1	484770.UFO1_3289	4.22e-151	489.0	COG1167@1|root,COG1167@2|Bacteria,1TPMY@1239|Firmicutes,4H7D8@909932|Negativicutes	909932|Negativicutes	EK	Alanine-glyoxylate amino-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_MocR
DEZH2_k127_7509442_0	203119.Cthe_0741	1.485e-219	689.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia,3WG9P@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
DEZH2_k127_7509442_3	509191.AEDB02000048_gene4641	5.109e-114	393.0	COG1948@1|root,COG4880@2|Bacteria,1TQK0@1239|Firmicutes,247VC@186801|Clostridia,3WIWG@541000|Ruminococcaceae	186801|Clostridia	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel,Cu_amine_oxidN1
DEZH2_k127_7509442_9	699246.HMPREF0868_1167	1.016e-38	154.0	COG2188@1|root,COG2188@2|Bacteria,1VECH@1239|Firmicutes,24EMG@186801|Clostridia	186801|Clostridia	K	GntR family	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
DEZH2_k127_7509442_8	1291050.JAGE01000002_gene3539	6.862e-42	160.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,3WGVY@541000|Ruminococcaceae	186801|Clostridia	E	aminotransferase class V	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
DEZH2_k127_7552759_1	401526.TcarDRAFT_1647	2.959e-47	183.0	COG1530@1|root,COG1530@2|Bacteria,1TQS4@1239|Firmicutes,4H1WZ@909932|Negativicutes	909932|Negativicutes	J	S1 RNA binding domain protein	rng	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
DEZH2_k127_7552759_0	1121335.Clst_0067	9.904e-95	316.0	COG1328@1|root,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,3WHPK@541000|Ruminococcaceae	186801|Clostridia	F	Ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
DEZH2_k127_7624945_4	545697.HMPREF0216_02947	1.144e-29	118.0	COG0624@1|root,COG0624@2|Bacteria,1TPEG@1239|Firmicutes,247SK@186801|Clostridia,36DX8@31979|Clostridiaceae	186801|Clostridia	E	Dipeptidase	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
DEZH2_k127_7624945_1	869213.JCM21142_62414	5.801e-100	332.0	COG0428@1|root,COG0428@2|Bacteria,4NGQ8@976|Bacteroidetes,47Q1J@768503|Cytophagia	976|Bacteroidetes	P	ZIP Zinc transporter	zupT	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
DEZH2_k127_7624945_3	345219.Bcoa_0726	3.348e-47	177.0	COG1309@1|root,COG1309@2|Bacteria,1VG3M@1239|Firmicutes,4IPKT@91061|Bacilli,1ZRC2@1386|Bacillus	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
DEZH2_k127_7624945_2	1123075.AUDP01000004_gene792	1.063e-47	173.0	COG1393@1|root,COG1393@2|Bacteria,1V6H8@1239|Firmicutes,24JH6@186801|Clostridia,3WK00@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the ArsC family	-	-	-	-	-	-	-	-	-	-	-	-	ArsC,Glutaredoxin
DEZH2_k127_7624945_5	1105031.HMPREF1141_1582	3.194e-25	110.0	COG1846@1|root,COG1846@2|Bacteria,1VDF4@1239|Firmicutes,24SUR@186801|Clostridia	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
DEZH2_k127_7624945_0	41431.PCC8801_0690	1.33e-112	371.0	COG1819@1|root,COG1819@2|Bacteria,1G036@1117|Cyanobacteria,3KIRB@43988|Cyanothece	1117|Cyanobacteria	CG	glycosyl transferase family 28	-	-	2.4.1.173	ko:K05841	-	-	-	-	ko00000,ko01000,ko01003	-	GT1	-	Glyco_transf_28,UDPGT
DEZH2_k127_7672564_1	555088.DealDRAFT_1294	2.097e-58	212.0	28HHD@1|root,2Z7T3@2|Bacteria,1TRKJ@1239|Firmicutes,24A0Y@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF3810
DEZH2_k127_7672564_0	1410638.JHXJ01000039_gene970	4.856e-61	221.0	COG0635@1|root,COG0635@2|Bacteria,1TREM@1239|Firmicutes,247JT@186801|Clostridia,3WGA8@541000|Ruminococcaceae	186801|Clostridia	C	Coproporphyrinogen dehydrogenase	hemZ	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DEZH2_k127_7680577_1	931626.Awo_c21300	3.579e-24	104.0	COG2146@1|root,COG2146@2|Bacteria,1VF0R@1239|Firmicutes,24UDZ@186801|Clostridia	186801|Clostridia	P	PFAM Rieske 2Fe-2S domain	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
DEZH2_k127_7680577_0	319795.Dgeo_2783	2.503e-223	704.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
DEZH2_k127_7681847_1	877414.ATWA01000080_gene2231	1.1e-82	284.0	COG1819@1|root,COG1819@2|Bacteria,1TSPC@1239|Firmicutes,24D1S@186801|Clostridia	186801|Clostridia	CG	TIGRFAM glycosyltransferase, MGT family	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
DEZH2_k127_7681847_0	1301100.HG529388_gene5008	1.519e-223	705.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,36W7H@31979|Clostridiaceae	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
DEZH2_k127_7693864_2	658655.HMPREF0988_00634	1.414e-81	287.0	COG1653@1|root,COG1653@2|Bacteria,1TPWV@1239|Firmicutes,24AWQ@186801|Clostridia,27KF0@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Domain of unknown function (DUF3502)	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	DUF3502,SBP_bac_1,SBP_bac_8
DEZH2_k127_7693864_0	658655.HMPREF0988_00633	3.145e-120	393.0	COG4209@1|root,COG4209@2|Bacteria,1TQFY@1239|Firmicutes,24923@186801|Clostridia,27INJ@186928|unclassified Lachnospiraceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
DEZH2_k127_7693864_1	97139.C824_00434	7.806e-111	366.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,36EVW@31979|Clostridiaceae	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
DEZH2_k127_770538_0	398512.JQKC01000021_gene3667	7.339e-282	879.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,3WGZ0@541000|Ruminococcaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
DEZH2_k127_7722238_1	646529.Desaci_0366	4.039e-69	246.0	COG4974@1|root,COG4974@2|Bacteria,1UCSJ@1239|Firmicutes,24BGK@186801|Clostridia,264TB@186807|Peptococcaceae	186801|Clostridia	L	Plasmid pRiA4b ORF-3-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3,SEC-C
DEZH2_k127_7722238_2	1235802.C823_03656	7.759e-50	187.0	28WNF@1|root,2ZIN7@2|Bacteria,1V2JM@1239|Firmicutes,24H79@186801|Clostridia,25WFM@186806|Eubacteriaceae	186801|Clostridia	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
DEZH2_k127_7722238_3	768706.Desor_1848	7.798e-49	177.0	COG3576@1|root,COG3576@2|Bacteria,1VC6T@1239|Firmicutes,24HPP@186801|Clostridia,2651Y@186807|Peptococcaceae	186801|Clostridia	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
DEZH2_k127_7722238_0	768706.Desor_1849	2.423e-80	270.0	COG1959@1|root,COG1959@2|Bacteria,1V6FG@1239|Firmicutes,24ACI@186801|Clostridia,263M9@186807|Peptococcaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
DEZH2_k127_7768493_6	412965.COSY_0789	0.000792	50.0	COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,1RYZ2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM Nitrate reductase gamma subunit	dsrM	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
DEZH2_k127_7768493_4	706587.Desti_3015	1.806e-28	117.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,42VCF@68525|delta/epsilon subdivisions,2WRI6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
DEZH2_k127_7768493_1	706587.Desti_3016	2.672e-71	244.0	COG2210@1|root,COG2210@2|Bacteria,1QZTN@1224|Proteobacteria,431JI@68525|delta/epsilon subdivisions,2WWC5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,TusA
DEZH2_k127_7768493_3	1443125.Z962_11910	5.617e-34	138.0	COG1671@1|root,COG1671@2|Bacteria,1V9Z0@1239|Firmicutes,24HPW@186801|Clostridia,36J4K@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0178 family	-	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
DEZH2_k127_7768493_2	545696.HOLDEFILI_01068	2.311e-40	158.0	COG2365@1|root,COG2365@2|Bacteria,1VA24@1239|Firmicutes,3VPSP@526524|Erysipelotrichia	526524|Erysipelotrichia	T	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Y_phosphatase3
DEZH2_k127_7768493_0	1118054.CAGW01000092_gene3593	1.766e-74	263.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,4HBBI@91061|Bacilli,26RQZ@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	trmH	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
DEZH2_k127_7769266_0	1392491.JIAE01000001_gene408	4.738e-145	477.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,3WGVW@541000|Ruminococcaceae	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
DEZH2_k127_7773122_5	755731.Clo1100_1223	1.082e-06	61.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC5,TPR_16,TPR_8
DEZH2_k127_7773122_1	203119.Cthe_1384	4.225e-92	320.0	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,3WGH0@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
DEZH2_k127_7773122_3	469596.HMPREF9488_00745	1.4e-19	95.0	COG2246@1|root,COG2246@2|Bacteria,1VESW@1239|Firmicutes,3VRWN@526524|Erysipelotrichia	526524|Erysipelotrichia	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
DEZH2_k127_7773122_4	316067.Geob_3347	8.337e-11	75.0	COG5184@1|root,COG5184@2|Bacteria,1QX3H@1224|Proteobacteria	1224|Proteobacteria	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like
DEZH2_k127_7773122_0	585394.RHOM_04770	4.57e-117	404.0	COG3103@1|root,COG4193@1|root,COG3103@2|Bacteria,COG4193@2|Bacteria,1TRTM@1239|Firmicutes,24C4N@186801|Clostridia	186801|Clostridia	GT	SH3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Dockerin_1,Glucosaminidase,SH3_3
DEZH2_k127_7773122_2	1392491.JIAE01000001_gene2308	4.236e-28	115.0	COG4193@1|root,COG4193@2|Bacteria,1TRTM@1239|Firmicutes,24C4N@186801|Clostridia,3WHI0@541000|Ruminococcaceae	186801|Clostridia	GT	SH3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Dockerin_1,Glucosaminidase,SH3_3
DEZH2_k127_7790903_1	1195236.CTER_4467	8.902e-53	202.0	COG1215@1|root,COG1215@2|Bacteria,1TRCI@1239|Firmicutes,248JA@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
DEZH2_k127_7790903_0	1195236.CTER_4467	7.886e-53	202.0	COG1215@1|root,COG1215@2|Bacteria,1TRCI@1239|Firmicutes,248JA@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
DEZH2_k127_779870_6	1120746.CCNL01000010_gene1177	1.568e-38	145.0	COG0573@1|root,COG0573@2|Bacteria,2NPS2@2323|unclassified Bacteria	2|Bacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037,ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
DEZH2_k127_779870_2	428125.CLOLEP_03849	2.673e-92	312.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,3WGN2@541000|Ruminococcaceae	186801|Clostridia	P	phosphate ABC transporter	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
DEZH2_k127_779870_0	428125.CLOLEP_03850	1.401e-123	402.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,3WGH2@541000|Ruminococcaceae	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
DEZH2_k127_779870_5	509191.AEDB02000109_gene5044	4.562e-49	186.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,3WIXN@541000|Ruminococcaceae	186801|Clostridia	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
DEZH2_k127_779870_3	645991.Sgly_0135	3.971e-70	244.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,2605V@186807|Peptococcaceae	186801|Clostridia	K	PFAM response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_779870_1	394503.Ccel_2107	2.502e-107	369.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36DIS@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636,ko:K07652	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
DEZH2_k127_779870_4	1410638.JHXJ01000005_gene2142	1.301e-55	199.0	COG1573@1|root,COG1573@2|Bacteria,1V267@1239|Firmicutes,24DFW@186801|Clostridia,3WIGX@541000|Ruminococcaceae	186801|Clostridia	L	Uracil-DNA glycosylase	udgA	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
DEZH2_k127_780878_4	1041930.Mtc_0212	7.456e-32	128.0	COG0440@1|root,arCOG04445@2157|Archaea,2XVFX@28890|Euryarchaeota,2N9NK@224756|Methanomicrobia	224756|Methanomicrobia	E	Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
DEZH2_k127_780878_1	1321778.HMPREF1982_00297	1.511e-90	307.0	COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia,26A91@186813|unclassified Clostridiales	186801|Clostridia	C	Phosphate acetyl/butaryl transferase	ptb	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747,GO:0050182	2.3.1.19	ko:K00634	ko00650,ko01100,map00650,map01100	-	R01174	RC00004,RC02816	ko00000,ko00001,ko01000	-	-	-	PTA_PTB
DEZH2_k127_780878_0	511051.CSE_02100	7.579e-106	354.0	COG3426@1|root,COG3426@2|Bacteria	2|Bacteria	C	butyrate kinase activity	buk	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase,PTA_PTB
DEZH2_k127_780878_5	445335.CBN_0412	1.207e-23	114.0	COG5279@1|root,COG5279@2|Bacteria,1V3HU@1239|Firmicutes,24CTX@186801|Clostridia,36VI6@31979|Clostridiaceae	186801|Clostridia	D	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_5,DUF5050,LRR_5,Transglut_core
DEZH2_k127_780878_7	935948.KE386495_gene2144	5.62e-16	82.0	2DNY2@1|root,32ZR4@2|Bacteria,1VEGZ@1239|Firmicutes,24RGC@186801|Clostridia,42H2A@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Late competence development protein ComFB	comFB	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
DEZH2_k127_780878_6	1304885.AUEY01000053_gene146	1.015e-20	102.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,42P8N@68525|delta/epsilon subdivisions,2WIWA@28221|Deltaproteobacteria,2MIT5@213118|Desulfobacterales	28221|Deltaproteobacteria	HP	PFAM ABC transporter related	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
DEZH2_k127_780878_3	742738.HMPREF9460_00116	1.032e-40	159.0	2AJWE@1|root,31AJA@2|Bacteria,1VATY@1239|Firmicutes,24MXD@186801|Clostridia,269EH@186813|unclassified Clostridiales	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_780878_2	203119.Cthe_0666	2.708e-81	281.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia,3WH9Z@541000|Ruminococcaceae	186801|Clostridia	O	SPFH Band 7 PHB domain protein	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
DEZH2_k127_7842399_5	699246.HMPREF0868_0341	2.973e-89	306.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,268A6@186813|unclassified Clostridiales	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
DEZH2_k127_7842399_7	699246.HMPREF0868_0340	4.543e-66	242.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,2682V@186813|unclassified Clostridiales	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
DEZH2_k127_7842399_4	699246.HMPREF0868_0339	1.059e-89	306.0	COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,247S7@186801|Clostridia,268KA@186813|unclassified Clostridiales	186801|Clostridia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
DEZH2_k127_7842399_6	699246.HMPREF0868_0338	1.427e-83	297.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,267JR@186813|unclassified Clostridiales	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
DEZH2_k127_7842399_9	1392491.JIAE01000001_gene937	1.504e-35	138.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,3WHE3@541000|Ruminococcaceae	186801|Clostridia	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
DEZH2_k127_7842399_2	1195236.CTER_5588	4.357e-114	380.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,3WHE3@541000|Ruminococcaceae	186801|Clostridia	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
DEZH2_k127_7842399_0	1392491.JIAE01000001_gene936	8.506e-158	526.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,3WGI4@541000|Ruminococcaceae	186801|Clostridia	M	Penicillin-binding Protein	ftsI	-	-	ko:K08384	ko00550,map00550	-	-	-	ko00000,ko00001,ko01011	-	-	-	PASTA,PBP_dimer,Transpeptidase
DEZH2_k127_7842399_10	588581.Cpap_1072	8.215e-06	55.0	COG2919@1|root,COG2919@2|Bacteria,1VK5R@1239|Firmicutes,24GRJ@186801|Clostridia	186801|Clostridia	D	cell division protein FtsL	-	-	-	-	-	-	-	-	-	-	-	-	DivIC,FtsL
DEZH2_k127_7842399_3	1410622.JNKY01000014_gene177	1.225e-102	346.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,27IQP@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
DEZH2_k127_7842399_8	1392491.JIAE01000001_gene933	2.064e-40	153.0	COG2001@1|root,COG2001@2|Bacteria	2|Bacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
DEZH2_k127_7842399_1	1392491.JIAE01000001_gene929	4.198e-127	417.0	COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,247WS@186801|Clostridia,3WJ15@541000|Ruminococcaceae	186801|Clostridia	D	Belongs to the SEDS family	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
DEZH2_k127_7842399_11	608534.GCWU000341_02844	9.275e-06	52.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24APG@186801|Clostridia,2PR0I@265975|Oribacterium	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
DEZH2_k127_7870830_1	755731.Clo1100_0047	1.865e-51	194.0	COG1484@1|root,COG1484@2|Bacteria,1TPKM@1239|Firmicutes,2483D@186801|Clostridia,36DQQ@31979|Clostridiaceae	186801|Clostridia	L	DNA replication protein	dnaC	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
DEZH2_k127_7870830_0	203119.Cthe_2419	2.903e-67	243.0	COG3935@1|root,COG3935@2|Bacteria,1VJUD@1239|Firmicutes,25Q73@186801|Clostridia,3WHU3@541000|Ruminococcaceae	186801|Clostridia	L	Replication initiation and membrane attachment	-	-	-	-	-	-	-	-	-	-	-	-	DnaB_2
DEZH2_k127_7870830_2	373903.Hore_20820	1.736e-29	119.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia,3WA9F@53433|Halanaerobiales	186801|Clostridia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
DEZH2_k127_7896363_7	1033737.CAEV01000001_gene2299	1.015e-15	81.0	COG0115@1|root,COG0115@2|Bacteria,1V3JS@1239|Firmicutes,24JA5@186801|Clostridia,36ISU@31979|Clostridiaceae	186801|Clostridia	EH	Aminotransferase class IV	pabC	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
DEZH2_k127_7896363_2	748727.CLJU_c36010	1.316e-109	372.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,36DMY@31979|Clostridiaceae	186801|Clostridia	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	pabB	-	2.6.1.85,4.1.3.27,4.1.3.38	ko:K01657,ko:K01665,ko:K03342,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716,R05553	RC00010,RC01418,RC01843,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Anth_synt_I_N,Chorismate_bind
DEZH2_k127_7896363_5	748727.CLJU_c36020	3.845e-59	210.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia,36I54@31979|Clostridiaceae	186801|Clostridia	EH	Glutamine amidotransferase of anthranilate synthase	pabA	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17720	GATase
DEZH2_k127_7896363_3	1280692.AUJL01000013_gene3348	3.253e-96	318.0	COG0655@1|root,COG0655@2|Bacteria,1TT84@1239|Firmicutes,248W0@186801|Clostridia,36E3H@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DEZH2_k127_7896363_4	1297617.JPJD01000020_gene434	1.193e-79	273.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,248AJ@186801|Clostridia,268M4@186813|unclassified Clostridiales	186801|Clostridia	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
DEZH2_k127_7896363_0	203119.Cthe_0372	1.052e-234	733.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3WGEA@541000|Ruminococcaceae	186801|Clostridia	C	glutamate synthase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
DEZH2_k127_7896363_1	755731.Clo1100_0656	1.93e-138	447.0	COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,36DFV@31979|Clostridiaceae	186801|Clostridia	C	Oxidoreductase	nfnA	-	1.18.1.2,1.19.1.1	ko:K00528,ko:K16951	ko00920,ko01120,map00920,map01120	-	R00858,R10146,R10159	RC00065	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
DEZH2_k127_7896363_6	555779.Dthio_PD2497	8.03e-45	168.0	COG1528@1|root,COG1528@2|Bacteria,1R9ZC@1224|Proteobacteria,42S74@68525|delta/epsilon subdivisions,2WNFJ@28221|Deltaproteobacteria,2MBEX@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Iron-storage protein	ftn	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
DEZH2_k127_7896363_8	457421.CBFG_03194	1.895e-15	78.0	COG0021@1|root,COG0021@2|Bacteria,1TPIB@1239|Firmicutes,25E6C@186801|Clostridia,26CJ4@186813|unclassified Clostridiales	186801|Clostridia	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
DEZH2_k127_7900644_7	552398.HMPREF0866_01248	2.208e-14	81.0	COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia,3WGFX@541000|Ruminococcaceae	186801|Clostridia	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
DEZH2_k127_7900644_2	445971.ANASTE_01974	9.04e-73	255.0	COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia,25W11@186806|Eubacteriaceae	186801|Clostridia	P	COG0226 ABC-type phosphate transport system, periplasmic component	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	Big_5,PBP_like_2
DEZH2_k127_7900644_5	699246.HMPREF0868_1352	1.049e-28	118.0	2ED8C@1|root,3374X@2|Bacteria,1W0C5@1239|Firmicutes,24S5N@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Smr
DEZH2_k127_7900644_3	292459.STH1527	6.822e-63	224.0	COG1187@1|root,COG1187@2|Bacteria,1TQZ2@1239|Firmicutes,248HC@186801|Clostridia	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rsuA	-	5.4.99.19	ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
DEZH2_k127_7900644_6	398512.JQKC01000066_gene4736	1.635e-14	83.0	COG2214@1|root,COG2214@2|Bacteria,1VDWZ@1239|Firmicutes,25JJY@186801|Clostridia,3WQ94@541000|Ruminococcaceae	186801|Clostridia	U	Heat shock protein DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7900644_0	699246.HMPREF0868_0952	5.48e-230	721.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,267P2@186813|unclassified Clostridiales	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
DEZH2_k127_7900644_4	699246.HMPREF0868_0953	6.52e-52	188.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia,269F8@186813|unclassified Clostridiales	186801|Clostridia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
DEZH2_k127_7900644_1	1392491.JIAE01000001_gene2218	9.042e-119	383.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,3WGWJ@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
DEZH2_k127_7901193_7	545695.TREAZ_2888	6.818e-13	69.0	COG1063@1|root,COG1063@2|Bacteria,2J6S3@203691|Spirochaetes	203691|Spirochaetes	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
DEZH2_k127_7901193_2	697281.Mahau_1767	4.803e-75	259.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,42EWH@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Ribulose-phosphate 3-epimerase	rpe	-	5.1.3.1	ko:K01783,ko:K17195	ko00030,ko00040,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529,R09031	RC00540,RC03111	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
DEZH2_k127_7901193_5	1123242.JH636435_gene2140	1.693e-48	184.0	COG1082@1|root,COG1082@2|Bacteria,2IWW9@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase domain protein TIM barrel	-	-	5.1.3.30,5.1.3.31	ko:K18910	-	-	R10817,R10818	RC03111,RC03283	ko00000,ko01000	-	-	-	AP_endonuc_2
DEZH2_k127_7901193_3	1410620.SHLA_36c000140	7.108e-61	220.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_7901193_1	1042156.CXIVA_15910	5.226e-111	366.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,Dockerin_1,RicinB_lectin_2
DEZH2_k127_7901193_0	1042156.CXIVA_15960	2.521e-114	378.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,36E3P@31979|Clostridiaceae	186801|Clostridia	C	PFAM Alcohol dehydrogenase	-	-	1.1.1.103,1.1.1.14	ko:K00008,ko:K00060	ko00040,ko00051,ko00260,ko01100,map00040,map00051,map00260,map01100	M00014	R00875,R01465,R01896	RC00085,RC00102,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
DEZH2_k127_7901193_4	986075.CathTA2_1130	2.368e-57	213.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,4HB9M@91061|Bacilli	91061|Bacilli	K	Transcriptional regulator	degA	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
DEZH2_k127_7901193_6	1423816.BACQ01000030_gene1076	6.696e-21	97.0	COG1070@1|root,COG1070@2|Bacteria,1UYIG@1239|Firmicutes,4HUWR@91061|Bacilli,3F9C6@33958|Lactobacillaceae	91061|Bacilli	G	FGGY family of carbohydrate kinases, C-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
DEZH2_k127_7937087_2	1248760.ANFZ01000005_gene2258	8.155e-79	266.0	COG1082@1|root,COG1082@2|Bacteria,1R8Q2@1224|Proteobacteria,2U2U4@28211|Alphaproteobacteria,2K7UW@204457|Sphingomonadales	204457|Sphingomonadales	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_7937087_1	588581.Cpap_2801	9.476e-95	321.0	COG1082@1|root,COG1082@2|Bacteria,1UTRI@1239|Firmicutes,2540X@186801|Clostridia	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
DEZH2_k127_7937087_3	203119.Cthe_0874	1.013e-67	235.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia,3WI4T@541000|Ruminococcaceae	186801|Clostridia	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
DEZH2_k127_7937087_0	203119.Cthe_0875	1.471e-126	414.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,3WHMI@541000|Ruminococcaceae	186801|Clostridia	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
DEZH2_k127_7956542_1	1392491.JIAE01000001_gene2438	6.766e-57	211.0	COG2720@1|root,COG2720@2|Bacteria,1TSH8@1239|Firmicutes,2493X@186801|Clostridia,3WRXM@541000|Ruminococcaceae	186801|Clostridia	V	VanW like protein	-	-	-	ko:K18346	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01504	-	-	-	G5,PG_binding_4,VanW
DEZH2_k127_7956542_4	649754.HMPREF0281_02505	3.767e-16	92.0	COG0494@1|root,COG0494@2|Bacteria,2I2GY@201174|Actinobacteria,22NHH@1653|Corynebacteriaceae	201174|Actinobacteria	L	NTP pyrophosphohydrolases including oxidative damage repair enzymes	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
DEZH2_k127_7956542_2	632292.Calhy_0862	1.4e-37	160.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,42GGH@68295|Thermoanaerobacterales	186801|Clostridia	S	SMART phosphoesterase PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
DEZH2_k127_7956542_0	1304880.JAGB01000001_gene546	1.221e-181	577.0	COG0235@1|root,COG0235@2|Bacteria,1UYFZ@1239|Firmicutes,24B39@186801|Clostridia	186801|Clostridia	G	PFAM class II aldolase adducin family protein	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
DEZH2_k127_7956542_3	1392491.JIAE01000001_gene384	2.192e-25	113.0	COG5427@1|root,COG5427@2|Bacteria,1UXXM@1239|Firmicutes,24EF9@186801|Clostridia,3WHFN@541000|Ruminococcaceae	186801|Clostridia	M	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_796295_1	1195236.CTER_0377	8.047e-96	322.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,3WH2F@541000|Ruminococcaceae	186801|Clostridia	G	ABC-type sugar transport system, ATPase component	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
DEZH2_k127_796295_3	1123075.AUDP01000038_gene249	5.724e-58	213.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,3WJH2@541000|Ruminococcaceae	186801|Clostridia	P	Ribose xylose arabinose galactoside ABC-type transport systems permease components	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_796295_0	545694.TREPR_1522	8.273e-171	547.0	COG0407@1|root,COG0407@2|Bacteria,2J9RK@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DEZH2_k127_796295_2	1069080.KB913028_gene259	5.026e-79	284.0	COG2199@1|root,COG2202@1|root,COG2203@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,4H568@909932|Negativicutes	909932|Negativicutes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9
DEZH2_k127_8025734_3	697329.Rumal_1508	4.629e-06	49.0	arCOG08054@1|root,2Z8AD@2|Bacteria,1TQ1J@1239|Firmicutes,2485U@186801|Clostridia,3WH6F@541000|Ruminococcaceae	186801|Clostridia	S	Carbohydrate-binding domain-containing protein Cthe_2159	-	GO:0001871,GO:0003674,GO:0005488,GO:0005509,GO:0030246,GO:0030247,GO:0030248,GO:0043167,GO:0043169,GO:0046872,GO:0048028,GO:2001062	-	-	-	-	-	-	-	-	-	-	Cthe_2159
DEZH2_k127_8025734_0	699246.HMPREF0868_1557	2.115e-121	400.0	COG3835@1|root,COG3835@2|Bacteria,1TQWD@1239|Firmicutes,24ZMW@186801|Clostridia,267Y4@186813|unclassified Clostridiales	186801|Clostridia	KT	PucR C-terminal helix-turn-helix domain	-	-	-	ko:K02647	-	-	-	-	ko00000,ko03000	-	-	-	HTH_30
DEZH2_k127_8025734_1	699246.HMPREF0868_1556	3.233e-97	323.0	COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,268V0@186813|unclassified Clostridiales	186801|Clostridia	D	ABC transporter	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
DEZH2_k127_8025734_2	1410638.JHXJ01000008_gene371	1.95e-43	165.0	COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia,3WHNT@541000|Ruminococcaceae	186801|Clostridia	D	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
DEZH2_k127_8033442_1	699246.HMPREF0868_1091	1.335e-144	469.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,267T4@186813|unclassified Clostridiales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
DEZH2_k127_8033442_2	1121335.Clst_2106	4.106e-95	319.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,3WGTY@541000|Ruminococcaceae	186801|Clostridia	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
DEZH2_k127_8033442_0	1121430.JMLG01000006_gene1778	1.306e-165	530.0	COG0499@1|root,COG0499@2|Bacteria,1TQY0@1239|Firmicutes,248S3@186801|Clostridia,2604M@186807|Peptococcaceae	186801|Clostridia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
DEZH2_k127_8033650_3	699246.HMPREF0868_1510	3.063e-34	135.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,267NK@186813|unclassified Clostridiales	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfA	-	-	ko:K16784,ko:K16786,ko:K16787	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
DEZH2_k127_8033650_1	588581.Cpap_1334	2.945e-78	269.0	COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,248AB@186801|Clostridia,3WGYM@541000|Ruminococcaceae	186801|Clostridia	P	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfT	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
DEZH2_k127_8033650_2	555079.Toce_0152	5.922e-60	216.0	COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia,42FMH@68295|Thermoanaerobacterales	186801|Clostridia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
DEZH2_k127_8033650_0	1304880.JAGB01000001_gene550	5.543e-193	612.0	COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,247NY@186801|Clostridia	186801|Clostridia	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C,QRPTase_N
DEZH2_k127_8033650_4	697282.Mettu_2040	3.237e-17	82.0	COG2132@1|root,COG4932@1|root,COG2132@2|Bacteria,COG4932@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8051795_1	483216.BACEGG_00986	2.023e-08	66.0	COG4447@1|root,COG4447@2|Bacteria,4NX71@976|Bacteroidetes,2FXP6@200643|Bacteroidia,4ATV2@815|Bacteroidaceae	976|Bacteroidetes	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8051795_0	394503.Ccel_2575	7.804e-147	471.0	COG2502@1|root,COG2502@2|Bacteria,1TP28@1239|Firmicutes,248S4@186801|Clostridia,36DK2@31979|Clostridiaceae	186801|Clostridia	E	aspartate--ammonia ligase	asnA	-	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	-	R00483	RC00010	ko00000,ko00001,ko01000	-	-	-	AsnA
DEZH2_k127_8051795_2	857293.CAAU_2540	8.978e-07	54.0	COG1266@1|root,COG1266@2|Bacteria,1VF60@1239|Firmicutes,24QSC@186801|Clostridia	186801|Clostridia	S	CAAX amino terminal protease family protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
DEZH2_k127_8058457_2	926569.ANT_30250	3.476e-44	166.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DEZH2_k127_8058457_1	1009370.ALO_21776	1.029e-70	248.0	COG0647@1|root,COG0647@2|Bacteria,1TQGM@1239|Firmicutes,4H1Z6@909932|Negativicutes	909932|Negativicutes	G	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro	-	-	-	ko:K02566	-	-	-	-	ko00000	-	-	-	Hydrolase_6,Hydrolase_like
DEZH2_k127_8058457_0	720554.Clocl_2532	6.115e-164	526.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,3WGTP@541000|Ruminococcaceae	186801|Clostridia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
DEZH2_k127_808371_1	1117379.BABA_08061	1.214e-07	60.0	COG1082@1|root,COG1082@2|Bacteria,1UZ90@1239|Firmicutes,4HHIS@91061|Bacilli,1ZEKQ@1386|Bacillus	91061|Bacilli	G	Xylose isomerase-like TIM barrel	inoDHR	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_808371_0	642492.Clole_3150	3.79e-132	428.0	COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1,PMI_typeI
DEZH2_k127_8090044_6	1291050.JAGE01000002_gene3274	8.787e-26	109.0	COG0629@1|root,COG0629@2|Bacteria,1V3WT@1239|Firmicutes,24HF9@186801|Clostridia,3WJ32@541000|Ruminococcaceae	186801|Clostridia	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
DEZH2_k127_8090044_5	699246.HMPREF0868_1384	3.021e-33	130.0	COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,24MQV@186801|Clostridia	186801|Clostridia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
DEZH2_k127_8090044_4	699246.HMPREF0868_0905	5.205e-40	153.0	COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,24MT6@186801|Clostridia	186801|Clostridia	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
DEZH2_k127_8090044_0	720554.Clocl_0124	5.35e-132	436.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,3WH8B@541000|Ruminococcaceae	186801|Clostridia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
DEZH2_k127_8090044_1	935948.KE386495_gene1643	2.411e-71	259.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,42F58@68295|Thermoanaerobacterales	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
DEZH2_k127_8090044_2	1195236.CTER_1582	3.562e-66	230.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,3WIX7@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
DEZH2_k127_8090044_3	699246.HMPREF0868_0901	5.939e-46	172.0	COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,2686J@186813|unclassified Clostridiales	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
DEZH2_k127_8106609_0	1391647.AVSV01000032_gene2693	4.755e-79	275.0	COG1807@1|root,COG1807@2|Bacteria,1V1V9@1239|Firmicutes,24GIM@186801|Clostridia,36NX3@31979|Clostridiaceae	186801|Clostridia	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8106609_1	1294142.CINTURNW_3546	2.462e-72	250.0	COG1285@1|root,COG1285@2|Bacteria,1V1GI@1239|Firmicutes,24G1I@186801|Clostridia,36HHF@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
DEZH2_k127_8125415_0	1121335.Clst_2054	3.63e-199	628.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,3WGBH@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
DEZH2_k127_8125415_1	1321778.HMPREF1982_00266	4.911e-08	59.0	COG4767@1|root,COG4767@2|Bacteria,1W034@1239|Firmicutes,24PYE@186801|Clostridia	186801|Clostridia	V	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
DEZH2_k127_8151388_0	203119.Cthe_2451	6.923e-180	599.0	COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,3WGFC@541000|Ruminococcaceae	186801|Clostridia	KL	SNF2 family	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
DEZH2_k127_8151388_4	1536770.R50345_15450	9.192e-56	206.0	COG2207@1|root,COG2207@2|Bacteria,1V5I2@1239|Firmicutes,4HMB9@91061|Bacilli,26QSW@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_18
DEZH2_k127_8151388_1	1304880.JAGB01000002_gene2262	5.727e-130	426.0	COG0673@1|root,COG0673@2|Bacteria,1U4A4@1239|Firmicutes,249UF@186801|Clostridia	186801|Clostridia	E	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
DEZH2_k127_8151388_2	97139.C824_02892	1.25e-109	361.0	COG0627@1|root,COG0627@2|Bacteria,1TPA9@1239|Firmicutes,24F6M@186801|Clostridia,36JC3@31979|Clostridiaceae	186801|Clostridia	S	Putative esterase	-	-	-	ko:K03930	-	-	-	-	ko00000,ko01000	-	CE1	-	Esterase
DEZH2_k127_8151388_3	1280681.AUJZ01000004_gene2740	3.966e-82	283.0	COG2730@1|root,COG2730@2|Bacteria,1UQKQ@1239|Firmicutes,25BW2@186801|Clostridia	186801|Clostridia	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
DEZH2_k127_8168024_0	509191.AEDB02000064_gene551	2.676e-312	965.0	COG0004@1|root,COG0347@1|root,COG0004@2|Bacteria,COG0347@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,3WH0N@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the P(II) protein family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
DEZH2_k127_8168024_3	588581.Cpap_0781	7.507e-16	81.0	2C033@1|root,337RJ@2|Bacteria,1VMRZ@1239|Firmicutes,24QDC@186801|Clostridia,3WMTZ@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8168024_2	1408321.JNJD01000012_gene2263	3.75e-128	437.0	COG1716@1|root,COG1716@2|Bacteria,1TS4P@1239|Firmicutes,24BY6@186801|Clostridia,27IJW@186928|unclassified Lachnospiraceae	186801|Clostridia	T	Clostripain family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C11
DEZH2_k127_8168024_1	663278.Ethha_2198	3.565e-149	477.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,3WGAK@541000|Ruminococcaceae	186801|Clostridia	U	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
DEZH2_k127_8170901_1	536227.CcarbDRAFT_1270	9.824e-25	113.0	COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,24G73@186801|Clostridia,36HY5@31979|Clostridiaceae	186801|Clostridia	J	GNAT family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
DEZH2_k127_8170901_0	457398.HMPREF0326_00175	7.132e-92	313.0	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,42SS9@68525|delta/epsilon subdivisions,2WPND@28221|Deltaproteobacteria,2MCRN@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	Steryl acetyl hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
DEZH2_k127_817829_0	332101.JIBU02000051_gene3436	3.828e-94	316.0	COG3272@1|root,COG4294@1|root,COG3272@2|Bacteria,COG4294@2|Bacteria,1TTCB@1239|Firmicutes,24BHY@186801|Clostridia,36FIA@31979|Clostridiaceae	186801|Clostridia	L	UV damage endonuclease UvdE	uvdE	-	-	ko:K13281	-	-	-	-	ko00000,ko01000	-	-	-	DUF1722,UvdE
DEZH2_k127_817829_2	1280689.AUJC01000004_gene323	1.409e-08	63.0	2E5T4@1|root,330HF@2|Bacteria,1VGGW@1239|Firmicutes,24RKP@186801|Clostridia,36PZF@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_817829_1	1089553.Tph_c19090	1.75e-45	168.0	COG2159@1|root,COG2159@2|Bacteria,1TRU0@1239|Firmicutes,248VZ@186801|Clostridia,42GGM@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM amidohydrolase 2	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
DEZH2_k127_8214972_3	1125863.JAFN01000001_gene964	9.972e-18	85.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,42NI1@68525|delta/epsilon subdivisions,2WK14@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
DEZH2_k127_8214972_1	699246.HMPREF0868_0938	3.2e-86	301.0	COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,267S9@186813|unclassified Clostridiales	186801|Clostridia	M	Peptidase family M50	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
DEZH2_k127_8214972_0	1121335.Clst_1378	9.75e-135	438.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,3WGBA@541000|Ruminococcaceae	186801|Clostridia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430	GcpE
DEZH2_k127_8214972_2	699246.HMPREF0868_0936	9.277e-57	216.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,267XE@186813|unclassified Clostridiales	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K02342,ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T
DEZH2_k127_8219638_2	1392491.JIAE01000001_gene659	2.687e-75	265.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,2493B@186801|Clostridia,3WHZ1@541000|Ruminococcaceae	186801|Clostridia	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
DEZH2_k127_8219638_0	1392491.JIAE01000001_gene658	1.121e-306	949.0	COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,248EB@186801|Clostridia,3WGEU@541000|Ruminococcaceae	186801|Clostridia	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
DEZH2_k127_8219638_1	699246.HMPREF0868_0455	2.829e-203	643.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,2683X@186813|unclassified Clostridiales	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
DEZH2_k127_8244731_0	699246.HMPREF0868_0967	1.01e-124	410.0	COG0342@1|root,COG0342@2|Bacteria,1TQVT@1239|Firmicutes,247X8@186801|Clostridia,267VQ@186813|unclassified Clostridiales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF
DEZH2_k127_8244731_1	699246.HMPREF0868_0966	5.353e-100	335.0	COG0341@1|root,COG0341@2|Bacteria,1TSZE@1239|Firmicutes,249A3@186801|Clostridia	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
DEZH2_k127_8244731_2	1499689.CCNN01000007_gene1278	7.141e-89	295.0	COG1592@1|root,COG1592@2|Bacteria,1TSUY@1239|Firmicutes,248GY@186801|Clostridia,36EFS@31979|Clostridiaceae	186801|Clostridia	C	Rubrerythrin	rbr3A	GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005506,GO:0006091,GO:0006950,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009266,GO:0009268,GO:0009408,GO:0009409,GO:0009628,GO:0009636,GO:0009651,GO:0009987,GO:0010035,GO:0010446,GO:0016209,GO:0016491,GO:0016684,GO:0016692,GO:0016999,GO:0017001,GO:0017144,GO:0022900,GO:0033554,GO:0034599,GO:0034605,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070417,GO:0070482,GO:0070887,GO:0071214,GO:0071236,GO:0071453,GO:0071467,GO:0071469,GO:0071470,GO:0071472,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:0104004,GO:1901700,GO:1901701,GO:1990748	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DEZH2_k127_8244731_3	1163671.JAGI01000002_gene3401	3.307e-15	83.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,36DXA@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the DEAD box helicase family	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
DEZH2_k127_8252175_1	762984.HMPREF9445_00306	3.27e-85	291.0	COG1979@1|root,COG1979@2|Bacteria,4NF1D@976|Bacteroidetes,2FPAW@200643|Bacteroidia,4AK9J@815|Bacteroidaceae	976|Bacteroidetes	C	Psort location Cytoplasmic, score	-	-	-	ko:K19955	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
DEZH2_k127_8252175_0	880073.Calab_0031	1.277e-104	349.0	COG2017@1|root,COG2017@2|Bacteria,2NQA5@2323|unclassified Bacteria	2|Bacteria	G	Converts alpha-aldose to the beta-anomer	mro	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
DEZH2_k127_8252175_2	1298598.JCM21714_2268	3.219e-75	269.0	COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,1TPJ8@1239|Firmicutes,4HA8X@91061|Bacilli,471P8@74385|Gracilibacillus	91061|Bacilli	G	Phosphotransferase system, EIIC	nagE	-	2.7.1.193,2.7.1.199	ko:K02802,ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	M00267,M00809	R02738,R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9	-	-	PTS_EIIA_1,PTS_EIIB,PTS_EIIC
DEZH2_k127_8252175_3	1121335.Clst_1023	5.611e-11	63.0	COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,3WI3M@541000|Ruminococcaceae	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
DEZH2_k127_8258014_0	641112.ACOK01000055_gene3807	6.02e-278	871.0	COG0318@1|root,COG1082@1|root,COG0318@2|Bacteria,COG1082@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,3WHKA@541000|Ruminococcaceae	186801|Clostridia	GIQ	AMP-dependent synthetase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C,AP_endonuc_2
DEZH2_k127_8258014_1	1392491.JIAE01000001_gene618	2.683e-57	208.0	COG3503@1|root,COG3503@2|Bacteria,1V8H3@1239|Firmicutes,24JRC@186801|Clostridia,3WJIA@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
DEZH2_k127_8258014_2	247490.KSU1_B0710	2.053e-49	184.0	COG0546@1|root,COG0546@2|Bacteria,2J0GC@203682|Planctomycetes	203682|Planctomycetes	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
DEZH2_k127_8258014_3	445972.ANACOL_04270	2.301e-05	53.0	28HHD@1|root,2Z7T3@2|Bacteria,1TRKJ@1239|Firmicutes,24A0Y@186801|Clostridia,3WI6G@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF3810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3810
DEZH2_k127_8260766_0	1304284.L21TH_0249	5.126e-151	494.0	COG1982@1|root,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia,36DPH@31979|Clostridiaceae	186801|Clostridia	E	Orn Lys Arg decarboxylase major	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
DEZH2_k127_8260766_1	663278.Ethha_1611	2.615e-68	238.0	COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,2493V@186801|Clostridia,3WHCY@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
DEZH2_k127_8312965_0	994573.T472_0216900	1.709e-189	598.0	COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,36EFP@31979|Clostridiaceae	186801|Clostridia	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
DEZH2_k127_8312965_1	398512.JQKC01000007_gene1155	5.917e-48	183.0	COG5482@1|root,COG5482@2|Bacteria,1V3FI@1239|Firmicutes,24IKI@186801|Clostridia,3WPKS@541000|Ruminococcaceae	186801|Clostridia	S	Putative PD-(D/E)XK phosphodiesterase (DUF2161)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2161
DEZH2_k127_8312965_2	1033744.CAEL01000019_gene123	5.443e-15	78.0	COG1308@1|root,COG1308@2|Bacteria	2|Bacteria	K	protein transport	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
DEZH2_k127_8335481_3	632292.Calhy_2345	2.091e-30	132.0	COG1609@1|root,COG1609@2|Bacteria,1UZFZ@1239|Firmicutes,24H13@186801|Clostridia	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8335481_2	1536773.R70331_07060	1.333e-63	229.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,26VZC@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_8335481_0	632292.Calhy_2347	8.386e-182	582.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia	186801|Clostridia	G	import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
DEZH2_k127_8335481_1	632292.Calhy_2349	2.436e-71	254.0	COG2207@1|root,COG2207@2|Bacteria,1UNTF@1239|Firmicutes,248YN@186801|Clostridia	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
DEZH2_k127_8335481_4	1280664.AUIX01000019_gene2710	1.655e-26	111.0	COG0119@1|root,COG2207@1|root,COG0119@2|Bacteria,COG2207@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia,4BWT1@830|Butyrivibrio	186801|Clostridia	EK	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,HTH_18,LeuA_dimer
DEZH2_k127_8345316_1	1410628.JNKS01000005_gene1154	8.162e-50	180.0	COG1435@1|root,COG1435@2|Bacteria,1TRVM@1239|Firmicutes,24CVH@186801|Clostridia,27KRC@186928|unclassified Lachnospiraceae	186801|Clostridia	F	Thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
DEZH2_k127_8345316_0	1499683.CCFF01000016_gene911	4.324e-118	391.0	COG1216@1|root,COG1216@2|Bacteria,1VV6P@1239|Firmicutes,25EH9@186801|Clostridia,36UQB@31979|Clostridiaceae	186801|Clostridia	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DEZH2_k127_8349464_10	877455.Metbo_1709	4.258e-27	113.0	arCOG03571@1|root,arCOG03571@2157|Archaea,2Y1I5@28890|Euryarchaeota,23PT8@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
DEZH2_k127_8349464_9	1519439.JPJG01000011_gene46	4.251e-32	131.0	COG1618@1|root,COG1618@2|Bacteria,1VGU5@1239|Firmicutes,24QRA@186801|Clostridia,2N8JT@216572|Oscillospiraceae	186801|Clostridia	F	NTPase	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
DEZH2_k127_8349464_2	411467.BACCAP_02771	6.153e-133	433.0	COG0614@1|root,COG0614@2|Bacteria,1TQ11@1239|Firmicutes,2482R@186801|Clostridia,268Y1@186813|unclassified Clostridiales	186801|Clostridia	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
DEZH2_k127_8349464_5	138119.DSY3094	5.921e-92	310.0	COG1120@1|root,COG1120@2|Bacteria,1UYT8@1239|Firmicutes,24CJY@186801|Clostridia,264C7@186807|Peptococcaceae	186801|Clostridia	HP	ABC-type cobalamin Fe3 -siderophore transport system, ATPase component	-	-	3.6.3.34	ko:K02013,ko:K09820	ko02010,map02010	M00240,M00243	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14,3.A.1.15	-	-	ABC_tran
DEZH2_k127_8349464_3	756499.Desde_3628	5.945e-130	423.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,2612U@186807|Peptococcaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
DEZH2_k127_8349464_8	411461.DORFOR_01323	8.798e-39	151.0	COG0746@1|root,COG1763@1|root,COG0746@2|Bacteria,COG1763@2|Bacteria,1VA6T@1239|Firmicutes,24HFW@186801|Clostridia,27WTZ@189330|Dorea	186801|Clostridia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
DEZH2_k127_8349464_7	44251.PDUR_04360	3.948e-61	220.0	COG2186@1|root,COG2186@2|Bacteria,1V3Z4@1239|Firmicutes,4HG61@91061|Bacilli,274P2@186822|Paenibacillaceae	91061|Bacilli	K	FCD	lutR_1	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
DEZH2_k127_8349464_6	699246.HMPREF0868_1454	1.34e-75	261.0	COG0664@1|root,COG0664@2|Bacteria,1TSP9@1239|Firmicutes,24FRD@186801|Clostridia	186801|Clostridia	K	Cyclic nucleotide-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
DEZH2_k127_8349464_4	699246.HMPREF0868_1453	1.633e-94	326.0	COG1624@1|root,COG4856@1|root,COG1624@2|Bacteria,COG4856@2|Bacteria,1TPRW@1239|Firmicutes,249K8@186801|Clostridia,268WQ@186813|unclassified Clostridiales	186801|Clostridia	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
DEZH2_k127_8349464_1	1304880.JAGB01000003_gene1173	3.09e-154	501.0	COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,2499P@186801|Clostridia	186801|Clostridia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
DEZH2_k127_8349464_0	720554.Clocl_2979	7.561e-234	737.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,3WGUC@541000|Ruminococcaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
DEZH2_k127_8368257_0	1033810.HLPCO_000207	3.393e-106	352.0	COG1131@1|root,COG1131@2|Bacteria,2NP0I@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	cylA	-	-	ko:K01990,ko:K11050	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC_tran,DUF4162
DEZH2_k127_8368257_1	756499.Desde_2707	1.864e-72	256.0	COG0842@1|root,COG0842@2|Bacteria,1TSH0@1239|Firmicutes,24BEN@186801|Clostridia,264UM@186807|Peptococcaceae	186801|Clostridia	V	ABC-2 family transporter protein	-	-	-	ko:K01992,ko:K11051	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC2_membrane,ABC2_membrane_3
DEZH2_k127_8368257_2	1131730.BAVI_07941	1.55e-64	240.0	COG0657@1|root,COG0657@2|Bacteria,1TQHX@1239|Firmicutes,4HB91@91061|Bacilli,1ZB27@1386|Bacillus	91061|Bacilli	I	COG0657 Esterase lipase	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
DEZH2_k127_8368257_3	411470.RUMGNA_03346	8.587e-44	178.0	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia,3Y2DA@572511|Blautia	186801|Clostridia	H	Psort location Cytoplasmic, score 9.98	btuR	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
DEZH2_k127_8373832_1	1392491.JIAE01000001_gene1173	1.552e-157	502.0	COG0188@1|root,COG0188@2|Bacteria,1TPPU@1239|Firmicutes,24CU3@186801|Clostridia,3WG8X@541000|Ruminococcaceae	186801|Clostridia	L	PFAM DNA gyrase topoisomerase IV, subunit A	-	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
DEZH2_k127_8373832_0	699246.HMPREF0868_0974	1.344e-311	964.0	COG0187@1|root,COG0187@2|Bacteria,1TQ6U@1239|Firmicutes,249NI@186801|Clostridia,268KY@186813|unclassified Clostridiales	186801|Clostridia	L	TopoisomeraseII	-	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
DEZH2_k127_8391606_3	699246.HMPREF0868_1513	1.455e-67	231.0	COG0100@1|root,COG0100@2|Bacteria,1V3IK@1239|Firmicutes,24HIK@186801|Clostridia,268PI@186813|unclassified Clostridiales	186801|Clostridia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
DEZH2_k127_8391606_1	1414720.CBYM010000038_gene1774	1.745e-83	281.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,36DKK@31979|Clostridiaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
DEZH2_k127_8391606_0	699246.HMPREF0868_1512	9.83e-142	456.0	COG0202@1|root,COG0202@2|Bacteria,1TPR8@1239|Firmicutes,248DS@186801|Clostridia,2682A@186813|unclassified Clostridiales	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
DEZH2_k127_8391606_2	1392491.JIAE01000001_gene2470	5.244e-71	243.0	COG0203@1|root,COG0203@2|Bacteria,1V6JQ@1239|Firmicutes,24J9T@186801|Clostridia,3WIPC@541000|Ruminococcaceae	186801|Clostridia	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
DEZH2_k127_8391606_4	272563.CD630_01000	1.233e-61	216.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,25QIU@186804|Peptostreptococcaceae	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfA	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
DEZH2_k127_8393895_2	1121335.Clst_0497	4.059e-39	159.0	COG2367@1|root,COG2367@2|Bacteria,1V5VP@1239|Firmicutes,25B0P@186801|Clostridia,3WS8C@541000|Ruminococcaceae	186801|Clostridia	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2,LysM,PG_binding_1
DEZH2_k127_8393895_3	1392491.JIAE01000001_gene500	4.508e-23	101.0	COG4466@1|root,COG4466@2|Bacteria,1VEQM@1239|Firmicutes,24QN2@186801|Clostridia,3WMGE@541000|Ruminococcaceae	186801|Clostridia	S	Biofilm formation stimulator VEG	veg	-	-	-	-	-	-	-	-	-	-	-	VEG
DEZH2_k127_8393895_0	1286171.EAL2_c18010	1.98e-68	242.0	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,25VAB@186806|Eubacteriaceae	186801|Clostridia	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
DEZH2_k127_8393895_1	1408422.JHYF01000009_gene2122	4.105e-61	228.0	COG2843@1|root,COG2843@2|Bacteria,1UZW4@1239|Firmicutes,24950@186801|Clostridia,36WWA@31979|Clostridiaceae	186801|Clostridia	M	Bacterial capsule synthesis protein PGA_cap	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
DEZH2_k127_8393895_6	1209989.TepiRe1_2760	2.554e-09	60.0	2CBZM@1|root,33NU4@2|Bacteria,1VKF8@1239|Firmicutes,24W3W@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8393895_5	699246.HMPREF0868_1297	8.461e-13	70.0	COG0230@1|root,COG0230@2|Bacteria	2|Bacteria	J	Ribosomal protein L34	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
DEZH2_k127_8393895_4	203119.Cthe_2369	7.185e-20	92.0	COG0594@1|root,COG0594@2|Bacteria,1VA78@1239|Firmicutes,24QK5@186801|Clostridia,3WKGV@541000|Ruminococcaceae	186801|Clostridia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
DEZH2_k127_8398340_1	1499967.BAYZ01000151_gene1686	7.576e-66	243.0	COG0371@1|root,COG0371@2|Bacteria,2NRET@2323|unclassified Bacteria	2|Bacteria	C	Iron-containing alcohol dehydrogenase	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
DEZH2_k127_8398340_0	642492.Clole_3150	2.955e-108	355.0	COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1,PMI_typeI
DEZH2_k127_840706_3	706587.Desti_5539	7.655e-40	149.0	COG1951@1|root,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,42MC7@68525|delta/epsilon subdivisions,2WKIV@28221|Deltaproteobacteria,2MRCT@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM hydro-lyases, Fe-S type, tartrate fumarate subfamily, alpha region	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
DEZH2_k127_840706_2	477974.Daud_1253	1.211e-66	237.0	COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,24FRK@186801|Clostridia,261NM@186807|Peptococcaceae	186801|Clostridia	C	Fe-S type, tartrate fumarate subfamily, beta	fumB	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
DEZH2_k127_840706_4	180332.JTGN01000009_gene4264	3.181e-37	151.0	COG2169@1|root,COG2169@2|Bacteria,1UINQ@1239|Firmicutes,24D3G@186801|Clostridia	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
DEZH2_k127_840706_0	445971.ANASTE_00656	3.203e-113	381.0	COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,25URT@186806|Eubacteriaceae	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	MatE
DEZH2_k127_840706_1	1121413.JMKT01000015_gene313	4.937e-71	252.0	COG0642@1|root,COG2202@1|root,COG2203@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43ED4@68525|delta/epsilon subdivisions,2X81C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
DEZH2_k127_8421878_1	1469948.JPNB01000003_gene89	3.495e-39	171.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,36EYT@31979|Clostridiaceae	186801|Clostridia	G	Glycosyltransferase 36 associated	ndvB	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
DEZH2_k127_8421878_0	1120746.CCNL01000017_gene2805	0.0	1210.0	COG3459@1|root,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	ndvB	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase
DEZH2_k127_8446894_0	180332.JTGN01000004_gene2624	3.973e-152	496.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia	186801|Clostridia	G	import. Responsible for energy coupling to the transport system	rbsA	-	3.6.3.17	ko:K10441,ko:K10542	ko02010,map02010	M00212,M00214	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3	-	-	ABC_tran
DEZH2_k127_8446894_1	158189.SpiBuddy_0336	2.016e-52	198.0	COG1172@1|root,COG1172@2|Bacteria,2J6T9@203691|Spirochaetes	203691|Spirochaetes	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
DEZH2_k127_8460764_1	373903.Hore_19290	5.737e-110	364.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3WBKC@53433|Halanaerobiales	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DEZH2_k127_8460764_2	1304284.L21TH_2423	1.653e-70	248.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E4P@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147,ko:K11085,ko:K18888	ko02010,map02010	M00706	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DEZH2_k127_8460764_0	1304880.JAGB01000002_gene1914	1.287e-130	426.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DEZH2_k127_8460948_0	1392491.JIAE01000001_gene1419	0.0	1085.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,3WGRN@541000|Ruminococcaceae	186801|Clostridia	F	phosphoribosylformylglycinamidine synthase	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
DEZH2_k127_8460948_1	1392491.JIAE01000001_gene1354	1.247e-24	108.0	COG0326@1|root,COG0326@2|Bacteria,1TQEU@1239|Firmicutes,247ND@186801|Clostridia,3WGY6@541000|Ruminococcaceae	186801|Clostridia	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
DEZH2_k127_8460948_2	1410638.JHXJ01000013_gene2329	8.874e-12	66.0	COG0326@1|root,COG0326@2|Bacteria,1TQEU@1239|Firmicutes,247ND@186801|Clostridia,3WGY6@541000|Ruminococcaceae	186801|Clostridia	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
DEZH2_k127_8472452_0	446462.Amir_5535	1.262e-67	236.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4DZ0W@85010|Pseudonocardiales	201174|Actinobacteria	E	Branched-chain amino acid transport	livF	-	-	ko:K01995,ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
DEZH2_k127_8472452_1	428126.CLOSPI_01690	1.522e-26	120.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,3VNTH@526524|Erysipelotrichia	526524|Erysipelotrichia	P	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
DEZH2_k127_8483538_2	1256908.HMPREF0373_01934	8.763e-51	198.0	COG2340@1|root,COG2340@2|Bacteria,1VSZA@1239|Firmicutes,24Y3F@186801|Clostridia	186801|Clostridia	S	Cysteine-rich secretory protein family	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	-
DEZH2_k127_8483538_5	608506.COB47_2034	2.994e-27	119.0	2EGRS@1|root,33AHY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8483538_0	266265.Bxe_B1066	5.107e-115	379.0	COG1064@1|root,COG1064@2|Bacteria,1P0UC@1224|Proteobacteria,2VPCZ@28216|Betaproteobacteria,1KGVQ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
DEZH2_k127_8483538_1	926549.KI421517_gene1315	6.33e-71	248.0	COG3967@1|root,COG3967@2|Bacteria,4NJUM@976|Bacteroidetes,47MKC@768503|Cytophagia	976|Bacteroidetes	M	KR domain	-	-	-	ko:K14189	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
DEZH2_k127_8483538_6	67352.JODS01000038_gene6678	7.95e-14	77.0	COG3631@1|root,COG3631@2|Bacteria,2IFV4@201174|Actinobacteria	201174|Actinobacteria	S	Phenazine biosynthesis protein A/B	-	-	-	ko:K20260	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	R11493	RC03452	ko00000,ko00001,ko00002	-	-	-	PHZA_PHZB
DEZH2_k127_8483538_4	1121097.JCM15093_2984	2.9e-34	138.0	COG0778@1|root,COG0778@2|Bacteria,4NPN2@976|Bacteroidetes,2G33A@200643|Bacteroidia,4AW91@815|Bacteroidaceae	976|Bacteroidetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DEZH2_k127_8483538_3	2325.TKV_c12650	1.342e-44	168.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,247S5@186801|Clostridia,42ER8@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
DEZH2_k127_848636_4	699246.HMPREF0868_0959	7.051e-72	244.0	COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia,268FI@186813|unclassified Clostridiales	186801|Clostridia	T	PhoH-like protein	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
DEZH2_k127_848636_1	699246.HMPREF0868_0958	5.931e-137	462.0	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,249W0@186801|Clostridia	186801|Clostridia	O	metal-dependent phosphohydrolase 7TM intracellular region	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
DEZH2_k127_848636_6	398512.JQKC01000013_gene1347	1.383e-28	121.0	COG0319@1|root,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,24MQZ@186801|Clostridia,3WIDY@541000|Ruminococcaceae	186801|Clostridia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	3.5.4.5	ko:K01489,ko:K07042	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000,ko03009	-	-	-	UPF0054
DEZH2_k127_848636_2	699246.HMPREF0868_0957	2.228e-95	322.0	COG0319@1|root,COG1159@1|root,COG0319@2|Bacteria,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,24876@186801|Clostridia,2680T@186813|unclassified Clostridiales	186801|Clostridia	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
DEZH2_k127_848636_5	588581.Cpap_1560	1.387e-40	160.0	COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,249TI@186801|Clostridia,3WJ6A@541000|Ruminococcaceae	186801|Clostridia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
DEZH2_k127_848636_0	699246.HMPREF0868_0955	5.158e-187	612.0	COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia,267T0@186813|unclassified Clostridiales	186801|Clostridia	KL	HELICc2	dinG	-	3.1.12.1,3.6.4.12	ko:K07464,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400	-	-	-	DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1
DEZH2_k127_848636_3	394503.Ccel_3251	5.254e-72	249.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
DEZH2_k127_8501024_4	429009.Adeg_0116	1.651e-35	141.0	COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia,42GVS@68295|Thermoanaerobacterales	186801|Clostridia	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
DEZH2_k127_8501024_2	1121335.Clst_0749	1.496e-42	161.0	COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia,3WJBF@541000|Ruminococcaceae	186801|Clostridia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
DEZH2_k127_8501024_5	1195236.CTER_0897	2.421e-27	117.0	COG0711@1|root,COG0711@2|Bacteria,1V97P@1239|Firmicutes,24JGQ@186801|Clostridia,3WK11@541000|Ruminococcaceae	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8501024_3	445335.CBN_1468	2.957e-40	153.0	COG0537@1|root,COG0537@2|Bacteria,1V6UE@1239|Firmicutes,25CUG@186801|Clostridia,36X0W@31979|Clostridiaceae	186801|Clostridia	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	-	-	-	-	-	-	-	-	-	HIT
DEZH2_k127_8501024_0	1514668.JOOA01000002_gene2307	7.373e-147	472.0	COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,2480D@186801|Clostridia,3WGDG@541000|Ruminococcaceae	186801|Clostridia	E	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
DEZH2_k127_8501024_1	398512.JQKC01000016_gene2804	1.893e-143	460.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,3WGH5@541000|Ruminococcaceae	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
DEZH2_k127_8517734_2	877414.ATWA01000030_gene1206	6.548e-30	123.0	COG1819@1|root,COG1819@2|Bacteria,1TSPC@1239|Firmicutes,24D1S@186801|Clostridia	186801|Clostridia	CG	TIGRFAM glycosyltransferase, MGT family	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
DEZH2_k127_8517734_1	765420.OSCT_1871	2.705e-65	235.0	COG0483@1|root,COG0483@2|Bacteria,2G88V@200795|Chloroflexi	200795|Chloroflexi	G	inositol monophosphate 1-phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8517734_0	82654.Pse7367_0659	5.795e-198	629.0	COG1109@1|root,COG1109@2|Bacteria,1G20X@1117|Cyanobacteria,1H9G6@1150|Oscillatoriales	1117|Cyanobacteria	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
DEZH2_k127_852718_1	699246.HMPREF0868_1259	1.874e-61	217.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,268DQ@186813|unclassified Clostridiales	186801|Clostridia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
DEZH2_k127_852718_0	931276.Cspa_c29940	2.436e-142	473.0	COG2207@1|root,COG3664@1|root,COG2207@2|Bacteria,COG3664@2|Bacteria,1TQGI@1239|Firmicutes,2490Q@186801|Clostridia,36GCA@31979|Clostridiaceae	186801|Clostridia	K	family 39	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Glyco_hydro_39,HTH_18
DEZH2_k127_8536036_0	398512.JQKC01000008_gene954	1.976e-143	460.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,3WG9W@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DEZH2_k127_8536036_1	1256908.HMPREF0373_02020	6.854e-43	168.0	COG0583@1|root,COG0583@2|Bacteria,1TP77@1239|Firmicutes	1239|Firmicutes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
DEZH2_k127_8538136_2	871963.Desdi_1562	1.878e-16	80.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,261F5@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system, ATPase and permease component	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DEZH2_k127_8538136_0	385682.AFSL01000072_gene1322	8.784e-170	542.0	COG0524@1|root,COG0524@2|Bacteria,4NH8K@976|Bacteroidetes,2FM8P@200643|Bacteroidia,3XIZT@558415|Marinilabiliaceae	976|Bacteroidetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
DEZH2_k127_8538136_1	1209989.TepiRe1_1890	1.88e-45	166.0	COG3875@1|root,COG3875@2|Bacteria,1UYM4@1239|Firmicutes,24AR5@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
DEZH2_k127_8592887_1	642492.Clole_0158	3.136e-47	174.0	COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,247XK@186801|Clostridia	186801|Clostridia	E	O-acetylhomoserine	mdeA1	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
DEZH2_k127_8592887_0	1410638.JHXJ01000013_gene2276	8.348e-154	499.0	COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,3WG85@541000|Ruminococcaceae	186801|Clostridia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iHN637.CLJU_RS20420	Mur_ligase_C,Mur_ligase_M
DEZH2_k127_8592887_2	293826.Amet_1436	1.151e-21	94.0	COG1670@1|root,COG1670@2|Bacteria,1V1VS@1239|Firmicutes,24HZU@186801|Clostridia,36IWH@31979|Clostridiaceae	186801|Clostridia	J	GNAT family	-	-	-	ko:K03825	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
DEZH2_k127_8601100_0	469617.FUAG_01525	3.839e-114	376.0	COG0655@1|root,COG0655@2|Bacteria,379NH@32066|Fusobacteria	32066|Fusobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DEZH2_k127_8601100_1	720554.Clocl_1132	8.717e-64	227.0	COG1387@1|root,COG1387@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,3WIW2@541000|Ruminococcaceae	186801|Clostridia	E	PHP domain protein	-	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	PHP
DEZH2_k127_8601100_2	545693.BMQ_3490	9.06e-05	49.0	COG1876@1|root,COG3103@1|root,COG3807@1|root,COG1876@2|Bacteria,COG3103@2|Bacteria,COG3807@2|Bacteria,1V1F7@1239|Firmicutes,4HBR1@91061|Bacilli,1ZCAG@1386|Bacillus	91061|Bacilli	M	D-alanyl-D-alanine carboxypeptidase	vanYB	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	VanY
DEZH2_k127_8621878_1	755731.Clo1100_2794	7.977e-28	115.0	COG1304@1|root,COG1304@2|Bacteria,1TPC4@1239|Firmicutes,249TX@186801|Clostridia,36F63@31979|Clostridiaceae	186801|Clostridia	C	FMN-dependent	-	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
DEZH2_k127_8621878_0	332101.JIBU02000053_gene3504	2.896e-142	467.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,36DME@31979|Clostridiaceae	186801|Clostridia	P	import. Responsible for energy coupling to the transport system	rbsA	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
DEZH2_k127_8632833_5	1195236.CTER_2182	3.067e-53	197.0	COG4636@1|root,COG4636@2|Bacteria,1TT8T@1239|Firmicutes,25DP3@186801|Clostridia	186801|Clostridia	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
DEZH2_k127_8632833_4	1321778.HMPREF1982_01070	4.23e-76	271.0	COG0477@1|root,COG2814@2|Bacteria,1UM9R@1239|Firmicutes,2486D@186801|Clostridia	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DEZH2_k127_8632833_1	585394.RHOM_07990	1.35e-103	343.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia	186801|Clostridia	T	response regulator receiver	-	-	-	ko:K07775	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_8632833_0	1280692.AUJL01000001_gene118	1.377e-160	519.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,36UII@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
DEZH2_k127_8632833_3	479434.Sthe_0724	9.926e-95	323.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2G5WG@200795|Chloroflexi,27XRJ@189775|Thermomicrobia	189775|Thermomicrobia	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
DEZH2_k127_8632833_6	1395513.P343_01585	1.222e-49	196.0	COG0642@1|root,COG2205@2|Bacteria,1TRAB@1239|Firmicutes,4HAXE@91061|Bacilli	91061|Bacilli	T	Domain of unknown function (DUF4173)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4173
DEZH2_k127_8632833_9	588581.Cpap_2329	6.117e-19	92.0	2E2F7@1|root,32XJJ@2|Bacteria,1VD4F@1239|Firmicutes,24IWM@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8632833_8	411467.BACCAP_04451	2.904e-27	111.0	COG3655@1|root,COG3655@2|Bacteria,1VESP@1239|Firmicutes,24QSQ@186801|Clostridia,269GD@186813|unclassified Clostridiales	186801|Clostridia	K	Cro/C1-type HTH DNA-binding domain	-	-	-	ko:K07727	-	-	-	-	ko00000,ko03000	-	-	-	HTH_26
DEZH2_k127_8632833_10	768706.Desor_3614	9.356e-09	63.0	2BREV@1|root,32KDP@2|Bacteria,1V778@1239|Firmicutes,25AY8@186801|Clostridia,265EW@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF2975)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2975
DEZH2_k127_8632833_2	1123009.AUID01000011_gene2270	1.121e-98	335.0	COG0583@1|root,COG0583@2|Bacteria,1V333@1239|Firmicutes,25C6Y@186801|Clostridia,26CHS@186813|unclassified Clostridiales	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
DEZH2_k127_8632833_7	278957.ABEA03000180_gene2021	2.391e-44	165.0	COG1178@1|root,COG1178@2|Bacteria,46SFB@74201|Verrucomicrobia,3K7UZ@414999|Opitutae	414999|Opitutae	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
DEZH2_k127_8668338_1	316067.Geob_2672	3.034e-73	252.0	2CHQE@1|root,33UHW@2|Bacteria,1NVHB@1224|Proteobacteria,42ZMN@68525|delta/epsilon subdivisions,2WUYW@28221|Deltaproteobacteria,43UQN@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8668338_0	316067.Geob_2671	6.706e-104	347.0	2B9FT@1|root,322TS@2|Bacteria,1RKUJ@1224|Proteobacteria,42SNA@68525|delta/epsilon subdivisions,2WPES@28221|Deltaproteobacteria,43SKX@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8696206_1	272623.L145420	1.606e-47	174.0	COG3865@1|root,COG3865@2|Bacteria,1TP7B@1239|Firmicutes,4HDPM@91061|Bacilli,1YCJW@1357|Lactococcus	91061|Bacilli	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
DEZH2_k127_8696206_0	1121422.AUMW01000013_gene1523	2.625e-166	531.0	COG2230@1|root,COG2230@2|Bacteria,1TSG4@1239|Firmicutes,248GV@186801|Clostridia,263MH@186807|Peptococcaceae	186801|Clostridia	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	cfa	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
DEZH2_k127_8696206_2	1123065.ATWL01000056_gene574	8.765e-32	132.0	COG0726@1|root,COG0726@2|Bacteria,2HEQK@201174|Actinobacteria	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
DEZH2_k127_8718505_2	1121121.KB894287_gene3517	4.946e-122	400.0	COG0686@1|root,COG0686@2|Bacteria,1TNZ5@1239|Firmicutes,4HABX@91061|Bacilli,26SM7@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
DEZH2_k127_8718505_1	1121324.CLIT_10c02150	6.853e-143	465.0	COG0477@1|root,COG2814@2|Bacteria,1UY64@1239|Firmicutes,249MW@186801|Clostridia	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DEZH2_k127_8718505_5	1410668.JNKC01000001_gene1701	2.908e-22	100.0	2DNND@1|root,32Y8Y@2|Bacteria,1VHFD@1239|Firmicutes,24TRD@186801|Clostridia,36PAA@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8718505_0	1304880.JAGB01000001_gene985	6.646e-163	522.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia	186801|Clostridia	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DEZH2_k127_8718505_4	1128398.Curi_c27860	1.553e-46	175.0	COG0745@1|root,COG0745@2|Bacteria,1TT73@1239|Firmicutes,2487E@186801|Clostridia,26A01@186813|unclassified Clostridiales	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_8718505_6	1391646.AVSU01000099_gene343	7.761e-16	78.0	COG1141@1|root,COG1141@2|Bacteria,1VKVT@1239|Firmicutes,24RTU@186801|Clostridia,25UEJ@186804|Peptostreptococcaceae	186801|Clostridia	C	4Fe-4S single cluster domain of Ferredoxin I	fdxA	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
DEZH2_k127_8718505_3	643648.Slip_1694	1.443e-67	241.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,42JYS@68298|Syntrophomonadaceae	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
DEZH2_k127_8718505_7	1047013.AQSP01000138_gene1027	0.0002746	48.0	2E9DF@1|root,333M0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8721681_1	1121335.Clst_0657	3.782e-85	287.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,2494X@186801|Clostridia,3WIGS@541000|Ruminococcaceae	186801|Clostridia	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
DEZH2_k127_8721681_0	720554.Clocl_3129	7.359e-223	702.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,3WGH5@541000|Ruminococcaceae	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
DEZH2_k127_8727414_3	1203606.HMPREF1526_02461	1.665e-91	304.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,2480A@186801|Clostridia,36DZ6@31979|Clostridiaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DEZH2_k127_8727414_0	138119.DSY5024	1.925e-140	454.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,248WH@186801|Clostridia,260FB@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DEZH2_k127_8727414_1	1226322.HMPREF1545_03873	8.017e-138	443.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia,2N6JA@216572|Oscillospiraceae	186801|Clostridia	E	Branched-chain amino acid ATP-binding cassette transporter	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
DEZH2_k127_8727414_2	1297617.JPJD01000082_gene1040	4.581e-105	351.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,268B5@186813|unclassified Clostridiales	186801|Clostridia	E	ATPases associated with a variety of cellular activities	livF1	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
DEZH2_k127_8727414_4	138119.DSY2398	1.563e-88	297.0	COG1296@1|root,COG1296@2|Bacteria,1TP8P@1239|Firmicutes,248NN@186801|Clostridia,2640U@186807|Peptococcaceae	186801|Clostridia	E	branched-chain amino acid	azlC	-	-	-	-	-	-	-	-	-	-	-	AzlC
DEZH2_k127_8727414_5	352165.HMPREF7215_1554	9.792e-30	123.0	COG1687@1|root,COG1687@2|Bacteria,3TCBT@508458|Synergistetes	508458|Synergistetes	E	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
DEZH2_k127_8727414_7	660470.Theba_2735	1.423e-14	75.0	COG1141@1|root,COG1141@2|Bacteria,2GDGB@200918|Thermotogae	200918|Thermotogae	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
DEZH2_k127_8727414_6	994573.T472_0218800	8.331e-16	78.0	COG1917@1|root,COG1917@2|Bacteria,1V723@1239|Firmicutes,24K1V@186801|Clostridia,36JQ8@31979|Clostridiaceae	186801|Clostridia	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
DEZH2_k127_8736354_4	697281.Mahau_1083	2.834e-29	119.0	COG1410@1|root,COG1410@2|Bacteria,1V0F4@1239|Firmicutes,25CEI@186801|Clostridia,42G54@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM dihydropteroate synthase, DHPS	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
DEZH2_k127_8736354_0	1410668.JNKC01000003_gene431	1.395e-111	366.0	COG4221@1|root,COG4221@2|Bacteria,1V03W@1239|Firmicutes,24910@186801|Clostridia	186801|Clostridia	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
DEZH2_k127_8736354_3	697281.Mahau_2869	4.862e-57	201.0	COG0569@1|root,COG0569@2|Bacteria,1V2ZF@1239|Firmicutes,24GNX@186801|Clostridia,42H6T@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM TrkA-N domain protein	trkA2	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_N
DEZH2_k127_8736354_1	697281.Mahau_2868	1.912e-79	271.0	COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia,42H8N@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM TrkA-N domain protein	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
DEZH2_k127_8736354_2	697281.Mahau_2866	7.197e-64	224.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,42GHF@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM cation transporter	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
DEZH2_k127_874228_2	710696.Intca_1055	3.887e-28	116.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4FFG4@85021|Intrasporangiaceae	201174|Actinobacteria	L	ATP-dependent DNA helicase	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
DEZH2_k127_874228_1	1042156.CXIVA_12080	1.234e-43	171.0	COG0583@1|root,COG0583@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K21960	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
DEZH2_k127_874228_0	931626.Awo_c11770	3.994e-62	225.0	COG0407@1|root,COG0407@2|Bacteria,1W73C@1239|Firmicutes,2502K@186801|Clostridia,25YP1@186806|Eubacteriaceae	931626.Awo_c11770|-	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_874228_3	883078.HMPREF9695_02692	7.749e-10	64.0	COG2128@1|root,COG2128@2|Bacteria,1QW8V@1224|Proteobacteria,2TWTB@28211|Alphaproteobacteria,3JZDW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8742286_2	1123242.JH636438_gene5872	2.702e-17	84.0	COG2120@1|root,COG2120@2|Bacteria,2IZ27@203682|Planctomycetes	203682|Planctomycetes	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
DEZH2_k127_8742286_1	1298920.KI911353_gene3683	5.325e-37	145.0	COG2452@1|root,COG2452@2|Bacteria,1VBG0@1239|Firmicutes,25H1U@186801|Clostridia	186801|Clostridia	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
DEZH2_k127_8742286_0	1449337.JQLL01000001_gene378	7.395e-55	199.0	COG3596@1|root,COG3597@1|root,COG3596@2|Bacteria,COG3597@2|Bacteria,1TSZW@1239|Firmicutes,4HAIB@91061|Bacilli,27FY3@186828|Carnobacteriaceae	91061|Bacilli	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	DUF697,MMR_HSR1
DEZH2_k127_8755125_1	657322.FPR_17820	3.581e-48	188.0	COG0657@1|root,COG0657@2|Bacteria,1UEU5@1239|Firmicutes,24BRQ@186801|Clostridia	2|Bacteria	I	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
DEZH2_k127_8755125_2	658655.HMPREF0988_02766	2.387e-37	155.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1UNTF@1239|Firmicutes,248YN@186801|Clostridia,27M1Y@186928|unclassified Lachnospiraceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
DEZH2_k127_8755125_0	588581.Cpap_0530	0.0	1031.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,3WJYC@541000|Ruminococcaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	enr	-	1.3.1.31	ko:K10797	ko00360,ko01120,map00360,map01120	-	R02252	RC00669	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
DEZH2_k127_8755125_3	590409.Dd586_2013	0.0003797	46.0	2DBDZ@1|root,2Z8Q4@2|Bacteria,1R552@1224|Proteobacteria,1RR0Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8770700_1	697281.Mahau_0861	2.18e-64	228.0	COG4786@1|root,COG4786@2|Bacteria,1TRA2@1239|Firmicutes,25EBP@186801|Clostridia,42J5Y@68295|Thermoanaerobacterales	186801|Clostridia	N	Flagellar basal body rod protein	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
DEZH2_k127_8770700_4	1128398.Curi_c15940	3.665e-13	72.0	COG1582@1|root,COG1582@2|Bacteria,1VKHB@1239|Firmicutes,24RWI@186801|Clostridia,26CCB@186813|unclassified Clostridiales	186801|Clostridia	N	Flagellar protein (FlbD)	flbD	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
DEZH2_k127_8770700_3	1094508.Tsac_1791	6.304e-17	86.0	COG1580@1|root,COG1580@2|Bacteria,1V9J2@1239|Firmicutes,24J8W@186801|Clostridia,42GMM@68295|Thermoanaerobacterales	186801|Clostridia	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
DEZH2_k127_8770700_0	509191.AEDB02000074_gene1768	3.611e-71	252.0	COG1868@1|root,COG1868@2|Bacteria,1TPTM@1239|Firmicutes,24AGV@186801|Clostridia,3WIQE@541000|Ruminococcaceae	186801|Clostridia	N	flagellar motor switch protein	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
DEZH2_k127_8770700_2	350688.Clos_1494	1.04e-56	205.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,1TPT8@1239|Firmicutes,24821@186801|Clostridia,36FD2@31979|Clostridiaceae	186801|Clostridia	N	flagellar motor switch protein	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	CheC,FliMN_C
DEZH2_k127_8806596_5	1304880.JAGB01000001_gene535	4.951e-61	216.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia	186801|Clostridia	C	dihydrolipoamide dehydrogenase	pdhD	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
DEZH2_k127_8806596_1	1304880.JAGB01000001_gene536	5.732e-141	461.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,247Q5@186801|Clostridia	186801|Clostridia	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
DEZH2_k127_8806596_2	545695.TREAZ_3435	2.794e-102	345.0	COG1028@1|root,COG1028@2|Bacteria,2J6IK@203691|Spirochaetes	203691|Spirochaetes	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.140	ko:K00068	ko00051,map00051	-	R05607	RC00085	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
DEZH2_k127_8806596_0	1121335.Clst_0827	3.717e-196	619.0	COG1063@1|root,COG1063@2|Bacteria,1TQ60@1239|Firmicutes,248JR@186801|Clostridia	186801|Clostridia	E	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	ko:K19956	ko00051,map00051	-	R03234	RC00089	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
DEZH2_k127_8806596_4	1304880.JAGB01000001_gene539	8.623e-82	279.0	COG1349@1|root,COG1349@2|Bacteria,1V25D@1239|Firmicutes,24GWY@186801|Clostridia	186801|Clostridia	K	transcriptional regulator DeoR family	-	-	-	ko:K02081	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
DEZH2_k127_8806596_3	1304880.JAGB01000001_gene151	1.711e-89	306.0	COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,247S9@186801|Clostridia	186801|Clostridia	H	Lipoate-protein ligase	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
DEZH2_k127_8846807_9	555088.DealDRAFT_2231	5.147e-11	65.0	COG3635@1|root,COG3635@2|Bacteria,1TQ5S@1239|Firmicutes,248U6@186801|Clostridia,42JI0@68298|Syntrophomonadaceae	186801|Clostridia	G	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
DEZH2_k127_8846807_6	1410638.JHXJ01000021_gene2368	6.24e-46	175.0	COG1192@1|root,COG1192@2|Bacteria,1UI32@1239|Firmicutes,25EC1@186801|Clostridia,3WREH@541000|Ruminococcaceae	186801|Clostridia	D	Involved in chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
DEZH2_k127_8846807_8	1291050.JAGE01000001_gene3191	2.538e-28	115.0	COG1143@1|root,COG1143@2|Bacteria,1UHZA@1239|Firmicutes,24QVY@186801|Clostridia,3WSIN@541000|Ruminococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
DEZH2_k127_8846807_0	1392491.JIAE01000001_gene1803	3.005e-171	543.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,3WH2U@541000|Ruminococcaceae	186801|Clostridia	C	ferredoxin oxidoreductase	vorB	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
DEZH2_k127_8846807_2	1392491.JIAE01000001_gene1802	8.082e-122	396.0	COG1013@1|root,COG1013@2|Bacteria,1UZ67@1239|Firmicutes,247Q7@186801|Clostridia,3WGN9@541000|Ruminococcaceae	186801|Clostridia	C	thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
DEZH2_k127_8846807_4	1392491.JIAE01000001_gene1801	1.135e-72	250.0	COG1014@1|root,COG1014@2|Bacteria,1UYYG@1239|Firmicutes,24I53@186801|Clostridia,3WJ35@541000|Ruminococcaceae	186801|Clostridia	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases gamma subunit	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
DEZH2_k127_8846807_7	1392491.JIAE01000001_gene1740	1.258e-34	145.0	COG0860@1|root,COG0860@2|Bacteria,1UY5Q@1239|Firmicutes,247Y6@186801|Clostridia,3WITB@541000|Ruminococcaceae	186801|Clostridia	M	N-acetylmuramoyl-L-alanine amidase	lytC_3	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3
DEZH2_k127_8846807_1	1519439.JPJG01000031_gene1729	1.294e-133	438.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,24ANI@186801|Clostridia,2N6UP@216572|Oscillospiraceae	186801|Clostridia	M	Glycosyl transferases group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
DEZH2_k127_8846807_5	1392491.JIAE01000001_gene1749	1.112e-50	184.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,3WJJS@541000|Ruminococcaceae	186801|Clostridia	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
DEZH2_k127_8846807_3	1392491.JIAE01000001_gene1748	6.701e-103	343.0	COG4100@1|root,COG4100@2|Bacteria,1TQ88@1239|Firmicutes,247Y4@186801|Clostridia,3WGF6@541000|Ruminococcaceae	186801|Clostridia	P	Cystathionine beta-lyase family protein involved in aluminum resistance	ynbB	-	-	-	-	-	-	-	-	-	-	-	Met_gamma_lyase
DEZH2_k127_8884427_1	1480694.DC28_14875	1.574e-88	299.0	COG0454@1|root,COG0456@2|Bacteria,2J7A2@203691|Spirochaetes	203691|Spirochaetes	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DEZH2_k127_8884427_0	208596.CAR_c05910	5.744e-110	362.0	COG2035@1|root,COG2035@2|Bacteria,1UYD5@1239|Firmicutes,4HBE3@91061|Bacilli,27G7R@186828|Carnobacteriaceae	91061|Bacilli	S	Domain of unknown function (DUF368)	XK27_00890	-	-	ko:K08974	-	-	-	-	ko00000	-	-	-	DUF368
DEZH2_k127_8884427_2	525257.HMPREF0204_13164	2.339e-51	187.0	COG1914@1|root,COG1914@2|Bacteria,4NDZ1@976|Bacteroidetes,1IG4N@117743|Flavobacteriia,3ZSV8@59732|Chryseobacterium	976|Bacteroidetes	P	Metal ion transporter, metal ion (Mn2 Fe2 ) transporter (Nramp) family	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
DEZH2_k127_8891127_1	1195236.CTER_2336	2.551e-106	349.0	COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia,3WG83@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N,PyrI_C
DEZH2_k127_8891127_0	203119.Cthe_0952	9.708e-160	513.0	COG0044@1|root,COG0044@2|Bacteria,1TPQM@1239|Firmicutes,247V2@186801|Clostridia,3WGV4@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
DEZH2_k127_8902855_2	768706.Desor_4482	3.315e-80	268.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
DEZH2_k127_8902855_3	290402.Cbei_1983	6.347e-75	257.0	COG2068@1|root,COG2068@2|Bacteria,1UY6E@1239|Firmicutes,249PV@186801|Clostridia,36FU4@31979|Clostridiaceae	186801|Clostridia	S	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,NTP_transf_3
DEZH2_k127_8902855_0	768706.Desor_4480	0.0	1187.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
DEZH2_k127_8902855_4	1403313.AXBR01000018_gene3571	3.853e-56	201.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,4HINQ@91061|Bacilli,1ZGEA@1386|Bacillus	91061|Bacilli	C	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs	-	-	1.17.1.4,1.2.5.3	ko:K00087,ko:K03518	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU32470	Fer2,Fer2_2
DEZH2_k127_8902855_1	1122947.FR7_3691	5.884e-122	396.0	COG1319@1|root,COG1319@2|Bacteria,1UZF3@1239|Firmicutes,4H909@909932|Negativicutes	909932|Negativicutes	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
DEZH2_k127_8907981_0	622312.ROSEINA2194_01607	2.044e-89	303.0	COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,247Q8@186801|Clostridia	186801|Clostridia	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
DEZH2_k127_8952402_3	635013.TherJR_0336	4.609e-40	151.0	COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,1TQH8@1239|Firmicutes,2491Q@186801|Clostridia,26152@186807|Peptococcaceae	186801|Clostridia	S	pfam ammecr1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
DEZH2_k127_8952402_0	555079.Toce_2077	5.983e-100	333.0	COG1180@1|root,COG1180@2|Bacteria,1TP46@1239|Firmicutes,248K9@186801|Clostridia,42F1Z@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
DEZH2_k127_8952402_1	768704.Desmer_2384	6.668e-78	282.0	COG2199@1|root,COG3706@2|Bacteria,1V6MC@1239|Firmicutes,24JED@186801|Clostridia,26754@186807|Peptococcaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,SBP_bac_3,TPR_12
DEZH2_k127_8952402_2	665956.HMPREF1032_02156	1.925e-51	190.0	COG0546@1|root,COG0546@2|Bacteria,1V7EI@1239|Firmicutes,24K0E@186801|Clostridia,3WPBF@541000|Ruminococcaceae	186801|Clostridia	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
DEZH2_k127_8952402_4	1392491.JIAE01000001_gene1531	7.615e-32	139.0	COG0791@1|root,COG0791@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia,3WHR8@541000|Ruminococcaceae	186801|Clostridia	M	NlpC/P60 family	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SH3_3
DEZH2_k127_8963576_3	1392491.JIAE01000001_gene1747	1.886e-48	187.0	COG0845@1|root,COG0845@2|Bacteria,1UY37@1239|Firmicutes,25Q6P@186801|Clostridia,3WHQW@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8963576_1	1392491.JIAE01000001_gene1746	3.135e-71	247.0	COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,3WGKD@541000|Ruminococcaceae	186801|Clostridia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	ylmE	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
DEZH2_k127_8963576_4	1291050.JAGE01000002_gene3921	2.131e-19	95.0	COG1799@1|root,COG1799@2|Bacteria,1VER3@1239|Firmicutes,24I9Y@186801|Clostridia,3WJJD@541000|Ruminococcaceae	186801|Clostridia	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	-	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
DEZH2_k127_8963576_0	913865.DOT_5198	1.941e-119	392.0	COG1215@1|root,COG1215@2|Bacteria,1VBC9@1239|Firmicutes,25EWA@186801|Clostridia	186801|Clostridia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DEZH2_k127_8963576_2	1291050.JAGE01000002_gene3824	7.948e-54	193.0	COG5146@1|root,COG5146@2|Bacteria,1V2R2@1239|Firmicutes,24DTK@186801|Clostridia	186801|Clostridia	H	TIGRFAM pantothenate kinase, eukaryotic staphyloccocal type	-	-	2.7.1.33	ko:K09680	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumble
DEZH2_k127_8982799_3	1122919.KB905666_gene4142	3.618e-18	98.0	COG2186@1|root,COG2186@2|Bacteria,1V33N@1239|Firmicutes,4HGDB@91061|Bacilli,26QYC@186822|Paenibacillaceae	91061|Bacilli	K	FCD	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
DEZH2_k127_8982799_1	1226322.HMPREF1545_00948	3.207e-42	171.0	COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,24AIB@186801|Clostridia	186801|Clostridia	K	FCD domain	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
DEZH2_k127_8982799_2	1499968.TCA2_4138	4.253e-38	145.0	COG1725@1|root,COG1725@2|Bacteria,1VAC6@1239|Firmicutes,4HKVW@91061|Bacilli,26XIK@186822|Paenibacillaceae	91061|Bacilli	K	GntR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GntR
DEZH2_k127_8982799_0	485913.Krac_2082	1.528e-75	264.0	COG1131@1|root,COG1131@2|Bacteria,2G7YS@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_9004876_3	1392491.JIAE01000001_gene1174	5.887e-11	65.0	COG0726@1|root,COG0726@2|Bacteria,1TWQ0@1239|Firmicutes,24BEF@186801|Clostridia,3WI2D@541000|Ruminococcaceae	186801|Clostridia	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
DEZH2_k127_9004876_0	699246.HMPREF0868_0971	1.072e-178	571.0	COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia	186801|Clostridia	E	Belongs to the aspartokinase family	thrA	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
DEZH2_k127_9004876_2	699246.HMPREF0868_0970	2.429e-30	126.0	COG2179@1|root,COG2179@2|Bacteria,1V6KM@1239|Firmicutes	1239|Firmicutes	F	HAD superfamily	yqeG	-	-	ko:K07015	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase,Hydrolase_like,PGP_phosphatase
DEZH2_k127_9004876_1	398512.JQKC01000006_gene792	1.689e-91	309.0	COG0648@1|root,COG0648@2|Bacteria,1UZNN@1239|Firmicutes,24A1E@186801|Clostridia,3WH4K@541000|Ruminococcaceae	186801|Clostridia	L	Endonuclease IV	Nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
DEZH2_k127_9026791_2	1235792.C808_00177	1.124e-117	389.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,2483M@186801|Clostridia,27IIR@186928|unclassified Lachnospiraceae	186801|Clostridia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06420	DXPR_C,DXP_redisom_C,DXP_reductoisom
DEZH2_k127_9026791_9	699246.HMPREF0868_0940	1.302e-55	205.0	COG4589@1|root,COG4589@2|Bacteria,1TT0Q@1239|Firmicutes,25HJP@186801|Clostridia	186801|Clostridia	S	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
DEZH2_k127_9026791_4	1410638.JHXJ01000002_gene1397	5.247e-97	325.0	COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,3WGF5@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
DEZH2_k127_9026791_7	1410638.JHXJ01000002_gene1396	1.62e-71	246.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,3WIRX@541000|Ruminococcaceae	186801|Clostridia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
DEZH2_k127_9026791_3	1392491.JIAE01000001_gene1522	6.182e-104	342.0	COG0528@1|root,COG0528@2|Bacteria,1TPXN@1239|Firmicutes,247KR@186801|Clostridia,3WGUN@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
DEZH2_k127_9026791_5	699246.HMPREF0868_0944	1.202e-95	317.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,267RB@186813|unclassified Clostridiales	186801|Clostridia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
DEZH2_k127_9026791_1	699246.HMPREF0868_0945	1.711e-125	406.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia,267MF@186813|unclassified Clostridiales	186801|Clostridia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
DEZH2_k127_9026791_8	1380408.AVGH01000013_gene681	2.662e-62	225.0	COG1360@1|root,COG1360@2|Bacteria,1UXY4@1239|Firmicutes,4HCCI@91061|Bacilli,21VDH@150247|Anoxybacillus	91061|Bacilli	N	OmpA family	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
DEZH2_k127_9026791_6	756499.Desde_0241	4.402e-75	260.0	COG1291@1|root,COG1291@2|Bacteria,1TRH1@1239|Firmicutes,24AEJ@186801|Clostridia,25ZZQ@186807|Peptococcaceae	186801|Clostridia	N	PFAM MotA TolQ ExbB proton channel	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
DEZH2_k127_9026791_10	871968.DESME_08515	2.14e-42	170.0	COG1670@1|root,COG1670@2|Bacteria,1V1ZC@1239|Firmicutes,249K2@186801|Clostridia,2661N@186807|Peptococcaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
DEZH2_k127_9026791_0	699246.HMPREF0868_1042	1.974e-215	679.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,268MU@186813|unclassified Clostridiales	186801|Clostridia	J	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
DEZH2_k127_9033089_0	699246.HMPREF0868_0863	2.699e-164	521.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,267ZX@186813|unclassified Clostridiales	186801|Clostridia	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
DEZH2_k127_9033089_2	1410638.JHXJ01000002_gene1406	8.143e-21	96.0	COG1862@1|root,COG1862@2|Bacteria,1VEMC@1239|Firmicutes,24MMT@186801|Clostridia,3WKMJ@541000|Ruminococcaceae	186801|Clostridia	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
DEZH2_k127_9033089_3	509191.AEDB02000002_gene1219	3.057e-16	80.0	2EGRK@1|root,33AHS@2|Bacteria,1VK9R@1239|Firmicutes,24UM0@186801|Clostridia,3WMB3@541000|Ruminococcaceae	186801|Clostridia	S	RSAM-modified six-cysteine peptide	scfA	-	-	-	-	-	-	-	-	-	-	-	SCIFF
DEZH2_k127_9033089_1	699246.HMPREF0868_0866	5.626e-77	264.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,267WA@186813|unclassified Clostridiales	186801|Clostridia	C	4Fe-4S single cluster domain	scfB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
DEZH2_k127_9096535_1	546268.NEISUBOT_03694	2.871e-05	54.0	COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,2VTYZ@28216|Betaproteobacteria,2KR9V@206351|Neisseriales	206351|Neisseriales	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
DEZH2_k127_9096535_0	398512.JQKC01000018_gene2948	5.641e-171	542.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,3WGST@541000|Ruminococcaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
DEZH2_k127_9100547_4	657322.FPR_17820	5.946e-30	125.0	COG0657@1|root,COG0657@2|Bacteria,1UEU5@1239|Firmicutes,24BRQ@186801|Clostridia	2|Bacteria	I	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
DEZH2_k127_9100547_0	1392491.JIAE01000001_gene2552	3.649e-83	287.0	COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,249IT@186801|Clostridia,3WPS4@541000|Ruminococcaceae	186801|Clostridia	F	Phosphoribulokinase / Uridine kinase family	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
DEZH2_k127_9100547_1	1118054.CAGW01000048_gene1634	3.867e-73	260.0	COG2818@1|root,COG2818@2|Bacteria,1UYWG@1239|Firmicutes,4HGWW@91061|Bacilli,26TEW@186822|Paenibacillaceae	91061|Bacilli	L	DNA-3-methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
DEZH2_k127_9100547_2	457412.RSAG_01983	7.029e-62	223.0	COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,24AVJ@186801|Clostridia,3WIKJ@541000|Ruminococcaceae	186801|Clostridia	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
DEZH2_k127_9100547_3	1195236.CTER_4094	1.146e-33	132.0	COG2211@1|root,COG2211@2|Bacteria,1TRP7@1239|Firmicutes,24B5F@186801|Clostridia	186801|Clostridia	G	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_2,PUCC
DEZH2_k127_9103536_1	1123075.AUDP01000022_gene3637	6.834e-62	216.0	COG0846@1|root,COG0846@2|Bacteria,1TQKD@1239|Firmicutes,2491J@186801|Clostridia,3WGSY@541000|Ruminococcaceae	186801|Clostridia	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
DEZH2_k127_9103536_0	553973.CLOHYLEM_04899	1.062e-119	394.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,220MG@1506553|Lachnoclostridium	186801|Clostridia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
DEZH2_k127_9103536_2	1286171.EAL2_c07850	5.973e-15	79.0	arCOG03165@1|root,30AIC@2|Bacteria,1V7NB@1239|Firmicutes,24M5X@186801|Clostridia,25YS2@186806|Eubacteriaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9110768_3	509191.AEDB02000064_gene551	2.033e-44	162.0	COG0004@1|root,COG0347@1|root,COG0004@2|Bacteria,COG0347@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,3WH0N@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the P(II) protein family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
DEZH2_k127_9110768_2	192952.MM_0566	1.106e-90	303.0	COG4912@1|root,arCOG05122@2157|Archaea,2XWYV@28890|Euryarchaeota,2N9IE@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
DEZH2_k127_9110768_0	545693.BMQ_5211	1.155e-209	662.0	COG0362@1|root,COG0362@2|Bacteria,1TP4I@1239|Firmicutes,4H9NC@91061|Bacilli,1ZC6M@1386|Bacillus	91061|Bacilli	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
DEZH2_k127_9110768_1	1321778.HMPREF1982_04242	2.02e-173	556.0	COG0364@1|root,COG0364@2|Bacteria,1TPYF@1239|Firmicutes,24939@186801|Clostridia,26AH2@186813|unclassified Clostridiales	186801|Clostridia	G	Glucose-6-phosphate dehydrogenase, NAD binding domain	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
DEZH2_k127_9121601_1	1131462.DCF50_p2283	1.277e-58	211.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,247NA@186801|Clostridia,2629Y@186807|Peptococcaceae	186801|Clostridia	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
DEZH2_k127_9121601_0	1131462.DCF50_p2284	1.79e-142	458.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,2610Q@186807|Peptococcaceae	186801|Clostridia	C	formate C-acetyltransferase glycine radical	pflB	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
DEZH2_k127_9124146_0	443144.GM21_0685	6.013e-197	631.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,43SAI@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_8,PAS_9,Response_reg
DEZH2_k127_9124146_1	269799.Gmet_2924	2.628e-07	55.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P5K@68525|delta/epsilon subdivisions,2WMEF@28221|Deltaproteobacteria,43TIX@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
DEZH2_k127_9127162_0	428125.CLOLEP_00228	1.386e-183	588.0	COG0119@1|root,COG0119@2|Bacteria,1TRIK@1239|Firmicutes,249Q4@186801|Clostridia,3WI0A@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
DEZH2_k127_9127162_1	1392491.JIAE01000001_gene1796	1.971e-151	486.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,3WG9G@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35,4.2.1.85	ko:K01703,ko:K20452	ko00290,ko00660,ko00760,ko00966,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map00966,map01100,map01110,map01120,map01210,map01230	M00432,M00535	R03069,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00843,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04465	Aconitase
DEZH2_k127_9129416_0	748727.CLJU_c03970	3.469e-145	482.0	COG0720@1|root,COG5617@1|root,COG0720@2|Bacteria,COG5617@2|Bacteria,1UXXS@1239|Firmicutes,249CZ@186801|Clostridia,36G7U@31979|Clostridiaceae	186801|Clostridia	H	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	PTPS,PTPS_related
DEZH2_k127_9154572_0	699246.HMPREF0868_1520	2.452e-141	456.0	COG0201@1|root,COG0201@2|Bacteria,1TPHB@1239|Firmicutes,248T9@186801|Clostridia,267VZ@186813|unclassified Clostridiales	186801|Clostridia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
DEZH2_k127_9154572_1	246194.CHY_1340	4.04e-71	247.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,42ES7@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
DEZH2_k127_9154572_2	699246.HMPREF0868_1518	3.166e-20	92.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,268HA@186813|unclassified Clostridiales	186801|Clostridia	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
DEZH2_k127_9172294_1	1286171.EAL2_808p07220	3.781e-59	209.0	COG0701@1|root,COG0701@2|Bacteria,1V49V@1239|Firmicutes,24FRM@186801|Clostridia,25YSK@186806|Eubacteriaceae	186801|Clostridia	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
DEZH2_k127_9172294_2	871968.DESME_05165	3.767e-56	198.0	COG5561@1|root,COG5561@2|Bacteria,1V8K2@1239|Firmicutes,24HKJ@186801|Clostridia	186801|Clostridia	S	CGGC	-	-	-	-	-	-	-	-	-	-	-	-	CGGC
DEZH2_k127_9172294_0	1304880.JAGB01000002_gene1807	1.58e-113	374.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia	186801|Clostridia	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
DEZH2_k127_9172294_3	1382356.JQMP01000003_gene1591	5.222e-15	87.0	COG1721@1|root,COG1721@2|Bacteria,2G6Y7@200795|Chloroflexi,27YYN@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
DEZH2_k127_9212617_1	1392491.JIAE01000001_gene1167	2.116e-94	319.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,2486F@186801|Clostridia,3WGI2@541000|Ruminococcaceae	186801|Clostridia	O	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03697	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small
DEZH2_k127_9212617_0	246194.CHY_0259	1.208e-115	376.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,42EYE@68295|Thermoanaerobacterales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
DEZH2_k127_9214872_0	412597.AEPN01000016_gene1201	1.701e-117	399.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,2PVRM@265|Paracoccus	28211|Alphaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
DEZH2_k127_9224026_1	398512.JQKC01000028_gene3893	5.214e-34	132.0	COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,3WI3M@541000|Ruminococcaceae	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
DEZH2_k127_9224026_0	398512.JQKC01000028_gene3893	1.379e-234	733.0	COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,3WI3M@541000|Ruminococcaceae	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
DEZH2_k127_925558_0	457570.Nther_0846	4.201e-187	601.0	COG0777@1|root,COG0825@1|root,COG0777@2|Bacteria,COG0825@2|Bacteria,1TP4U@1239|Firmicutes,248QK@186801|Clostridia	186801|Clostridia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS20740	ACCA,Carboxyl_trans
DEZH2_k127_925558_1	663278.Ethha_2646	7.103e-18	85.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,25E48@186801|Clostridia,3WHD3@541000|Ruminococcaceae	186801|Clostridia	I	acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
DEZH2_k127_9294053_0	861454.HMPREF9099_00194	3.605e-37	155.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,27I89@186928|unclassified Lachnospiraceae	186801|Clostridia	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
DEZH2_k127_9294053_1	1429916.X566_16330	1.984e-24	116.0	COG0747@1|root,COG0747@2|Bacteria,1PFW6@1224|Proteobacteria,2U1GT@28211|Alphaproteobacteria,3JUHW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Peptide ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
DEZH2_k127_9339597_2	411902.CLOBOL_06972	3.552e-29	119.0	COG0598@1|root,COG0598@2|Bacteria,1TPI8@1239|Firmicutes,24956@186801|Clostridia,21XS4@1506553|Lachnoclostridium	186801|Clostridia	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
DEZH2_k127_9339597_3	1304880.JAGB01000001_gene181	1.805e-24	106.0	COG1815@1|root,COG1815@2|Bacteria,1VEUZ@1239|Firmicutes,24RBE@186801|Clostridia	186801|Clostridia	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
DEZH2_k127_9339597_0	509191.AEDB02000074_gene1754	1.103e-40	156.0	COG1558@1|root,COG1558@2|Bacteria,1V6NB@1239|Firmicutes,24JJW@186801|Clostridia,3WK29@541000|Ruminococcaceae	186801|Clostridia	N	Belongs to the flagella basal body rod proteins family	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
DEZH2_k127_9339597_4	1304880.JAGB01000001_gene183	6.548e-14	75.0	COG1677@1|root,COG1677@2|Bacteria,1VEEY@1239|Firmicutes,24R4F@186801|Clostridia	186801|Clostridia	N	PFAM flagellar hook-basal body complex protein FliE	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
DEZH2_k127_9339597_1	1304880.JAGB01000001_gene184	1.172e-32	136.0	COG1766@1|root,COG1766@2|Bacteria,1TRK0@1239|Firmicutes,2498Q@186801|Clostridia	186801|Clostridia	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
DEZH2_k127_9376754_1	1408437.JNJN01000003_gene1606	7.235e-72	246.0	COG0221@1|root,COG0221@2|Bacteria,1V2DF@1239|Firmicutes,24G1A@186801|Clostridia,25WEI@186806|Eubacteriaceae	186801|Clostridia	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
DEZH2_k127_9376754_0	1499967.BAYZ01000032_gene1133	1.356e-178	565.0	COG0205@1|root,COG0205@2|Bacteria,2NP3J@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
DEZH2_k127_9418701_4	138119.DSY0552	2.256e-08	58.0	2DC2G@1|root,2ZCMT@2|Bacteria,1V2V5@1239|Firmicutes,24G0A@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9418701_1	931626.Awo_c05090	2.535e-62	219.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,25B5Z@186801|Clostridia	186801|Clostridia	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD,Redoxin
DEZH2_k127_9418701_0	138119.DSY1196	4.196e-100	331.0	COG0785@1|root,COG0785@2|Bacteria,1TQH1@1239|Firmicutes,249IS@186801|Clostridia,2649K@186807|Peptococcaceae	186801|Clostridia	O	PFAM cytochrome c biogenesis protein, transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
DEZH2_k127_9418701_3	646529.Desaci_2378	1.428e-20	98.0	2E9ZM@1|root,318K1@2|Bacteria,1V7PV@1239|Firmicutes,24T4K@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2680
DEZH2_k127_9418701_2	1121422.AUMW01000006_gene684	4.587e-56	201.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,261P1@186807|Peptococcaceae	186801|Clostridia	K	PFAM Response regulator receiver domain	-	-	-	ko:K07775	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_9427007_1	1089553.Tph_c19090	3.547e-41	156.0	COG2159@1|root,COG2159@2|Bacteria,1TRU0@1239|Firmicutes,248VZ@186801|Clostridia,42GGM@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM amidohydrolase 2	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
DEZH2_k127_9427007_0	203119.Cthe_0611	7.834e-132	431.0	COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia,3WHA0@541000|Ruminococcaceae	186801|Clostridia	J	Metallo-beta-lactamase domain protein	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
DEZH2_k127_9432466_5	268407.PWYN_16805	1.45e-45	167.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,4HA8B@91061|Bacilli,26USF@186822|Paenibacillaceae	91061|Bacilli	E	Saccharopine dehydrogenase	LYS1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
DEZH2_k127_9432466_2	1256908.HMPREF0373_01412	4.204e-56	201.0	COG0346@1|root,COG0346@2|Bacteria,1UT2Q@1239|Firmicutes,2510U@186801|Clostridia	186801|Clostridia	E	Glyoxalase-like domain	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
DEZH2_k127_9432466_6	877421.AUJT01000039_gene3575	1.102e-22	102.0	COG4392@1|root,COG4392@2|Bacteria,1VAKN@1239|Firmicutes,24N0I@186801|Clostridia,27PGD@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
DEZH2_k127_9432466_1	720554.Clocl_0964	2.733e-65	231.0	COG1296@1|root,COG1296@2|Bacteria,1TSXD@1239|Firmicutes,24CRN@186801|Clostridia,3WIDD@541000|Ruminococcaceae	186801|Clostridia	E	AzlC protein	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
DEZH2_k127_9432466_0	180332.JTGN01000001_gene4895	1.436e-129	435.0	COG1680@1|root,COG1680@2|Bacteria,1UUHI@1239|Firmicutes,24AX5@186801|Clostridia	186801|Clostridia	V	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
DEZH2_k127_9432466_7	748727.CLJU_c35250	1.215e-06	54.0	COG3462@1|root,COG3462@2|Bacteria,1VKBD@1239|Firmicutes	1239|Firmicutes	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
DEZH2_k127_9432466_3	1515615.HQ41_09105	2.284e-55	199.0	COG0386@1|root,COG0386@2|Bacteria,4NM6G@976|Bacteroidetes,2FTA9@200643|Bacteroidia,22Y8V@171551|Porphyromonadaceae	976|Bacteroidetes	O	Glutathione peroxidase	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
DEZH2_k127_9432466_4	696281.Desru_0257	1.212e-53	195.0	COG0484@1|root,COG0484@2|Bacteria,1TS44@1239|Firmicutes,24A9N@186801|Clostridia,261TS@186807|Peptococcaceae	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	CbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
DEZH2_k127_9436940_1	717605.Theco_0026	1.273e-47	172.0	COG4989@1|root,COG4989@2|Bacteria,1TQ12@1239|Firmicutes,4HA57@91061|Bacilli,26S2Q@186822|Paenibacillaceae	91061|Bacilli	S	aldo keto reductase	ydhF	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
DEZH2_k127_9436940_0	1410674.JNKU01000052_gene1210	1.101e-143	461.0	COG0655@1|root,COG0655@2|Bacteria,1TRAC@1239|Firmicutes,4I19K@91061|Bacilli	91061|Bacilli	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DEZH2_k127_9438193_6	97138.C820_02415	7.489e-42	158.0	COG1208@1|root,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
DEZH2_k127_9438193_1	1392491.JIAE01000001_gene1586	1.161e-124	411.0	COG0116@1|root,COG0116@2|Bacteria,1TP0X@1239|Firmicutes,248MA@186801|Clostridia,3WGN5@541000|Ruminococcaceae	186801|Clostridia	L	Belongs to the methyltransferase superfamily	ypsC	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
DEZH2_k127_9438193_10	1206729.BAFZ01000165_gene5817	5.269e-09	64.0	COG0671@1|root,COG0671@2|Bacteria,2I9FB@201174|Actinobacteria,4G24K@85025|Nocardiaceae	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
DEZH2_k127_9438193_2	350688.Clos_0889	2.186e-86	306.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia,36DZZ@31979|Clostridiaceae	186801|Clostridia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
DEZH2_k127_9438193_7	1408437.JNJN01000069_gene1301	1.253e-30	138.0	COG4769@1|root,COG4769@2|Bacteria,1V1M0@1239|Firmicutes,24MZC@186801|Clostridia,25WXG@186806|Eubacteriaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
DEZH2_k127_9438193_9	697281.Mahau_1955	8.864e-11	68.0	COG5341@1|root,COG5341@2|Bacteria,1VEPD@1239|Firmicutes,24QPH@186801|Clostridia,42GIW@68295|Thermoanaerobacterales	186801|Clostridia	S	NusG domain II	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	NusG_II
DEZH2_k127_9438193_5	545694.TREPR_3203	2.224e-53	194.0	COG2606@1|root,COG2606@2|Bacteria,2J83H@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
DEZH2_k127_9438193_4	1105031.HMPREF1141_2906	3.46e-60	211.0	COG2316@1|root,COG2316@2|Bacteria,1TSF7@1239|Firmicutes,24A1B@186801|Clostridia,36ECV@31979|Clostridiaceae	186801|Clostridia	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HD
DEZH2_k127_9438193_8	545694.TREPR_0374	1.388e-13	71.0	COG2316@1|root,COG2316@2|Bacteria,2J7SZ@203691|Spirochaetes	203691|Spirochaetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
DEZH2_k127_9438193_11	649764.HMPREF0762_01348	3.745e-05	46.0	COG1373@1|root,COG1373@2|Bacteria,2GK4E@201174|Actinobacteria,4CVEF@84998|Coriobacteriia	84998|Coriobacteriia	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
DEZH2_k127_9438193_0	478749.BRYFOR_08229	6.309e-311	973.0	COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia	186801|Clostridia	G	Alpha-L-rhamnosidase N-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
DEZH2_k127_9438193_3	411471.SUBVAR_04796	5.321e-67	246.0	COG2211@1|root,COG2211@2|Bacteria,1TS1S@1239|Firmicutes,24P87@186801|Clostridia	186801|Clostridia	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
DEZH2_k127_9489136_3	1120746.CCNL01000017_gene3024	4.878e-10	64.0	COG0169@1|root,COG0703@1|root,COG0169@2|Bacteria,COG0703@2|Bacteria,2NPR3@2323|unclassified Bacteria	2|Bacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroK	-	1.1.1.25,2.7.1.71,4.2.1.10,4.2.3.4	ko:K00014,ko:K00891,ko:K03785,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R02413,R03083,R03084	RC00002,RC00078,RC00206,RC00847,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,SKI,Shikimate_dh_N
DEZH2_k127_9489136_0	1408437.JNJN01000007_gene909	1.687e-133	433.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,25VN7@186806|Eubacteriaceae	186801|Clostridia	E	Psort location Cytoplasmic, score	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS14395	DAHP_synth_1
DEZH2_k127_9489136_1	272563.CD630_18330	6.813e-93	317.0	COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia,25RD6@186804|Peptostreptococcaceae	186801|Clostridia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
DEZH2_k127_9489136_2	1120746.CCNL01000017_gene3029	2.007e-64	234.0	COG0128@1|root,COG0128@2|Bacteria,2NNZ5@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
DEZH2_k127_9496429_0	1122947.FR7_3695	0.0	1233.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1TP7U@1239|Firmicutes,4H3QN@909932|Negativicutes	909932|Negativicutes	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
DEZH2_k127_9501528_1	768710.DesyoDRAFT_0673	2.521e-53	190.0	COG1373@1|root,COG1373@2|Bacteria,1TP7X@1239|Firmicutes,247ZX@186801|Clostridia,2611C@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
DEZH2_k127_9501528_0	926569.ANT_00560	6.764e-105	346.0	COG0428@1|root,COG0428@2|Bacteria,2G671@200795|Chloroflexi	200795|Chloroflexi	P	ZIP Zinc transporter	-	-	-	ko:K07238,ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11,2.A.5.5	-	-	Zip
DEZH2_k127_9501528_3	1122599.AUGR01000001_gene345	3.308e-27	121.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XJ1B@135619|Oceanospirillales	135619|Oceanospirillales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GAF_2,GGDEF,PAS_9
DEZH2_k127_9501528_2	1536772.R70723_02065	1.742e-29	124.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,4HGZI@91061|Bacilli,26TQ1@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
DEZH2_k127_9510259_3	877455.Metbo_1709	7.624e-21	93.0	arCOG03571@1|root,arCOG03571@2157|Archaea,2Y1I5@28890|Euryarchaeota,23PT8@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
DEZH2_k127_9510259_0	1120998.AUFC01000003_gene1476	1.198e-151	487.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia	186801|Clostridia	E	PFAM DAHP synthetase I	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
DEZH2_k127_9510259_2	476272.RUMHYD_02116	7.452e-92	310.0	COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia	186801|Clostridia	E	prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
DEZH2_k127_9510259_1	397290.C810_02032	3.049e-131	425.0	COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,247U8@186801|Clostridia,27I5W@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
DEZH2_k127_9534662_1	509191.AEDB02000065_gene728	1.615e-39	151.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,3WGPB@541000|Ruminococcaceae	186801|Clostridia	P	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
DEZH2_k127_9534662_0	588581.Cpap_0934	2.687e-234	733.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia,3WG9R@541000|Ruminococcaceae	186801|Clostridia	C	aconitate hydratase	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
DEZH2_k127_9557285_0	411459.RUMOBE_04201	8.777e-188	595.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,3XYSE@572511|Blautia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	yfmM	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
DEZH2_k127_9557285_5	1536774.H70357_01185	4.449e-65	226.0	2AKGE@1|root,31B89@2|Bacteria,1TYK3@1239|Firmicutes,4I7QK@91061|Bacilli,26X6P@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9557285_1	86416.Clopa_3790	4.079e-161	511.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,36DTX@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990,ko:K11050	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC_tran,DUF4162
DEZH2_k127_9557285_2	86416.Clopa_3789	4.404e-148	472.0	COG0842@1|root,COG0842@2|Bacteria,1UYEB@1239|Firmicutes,24BUQ@186801|Clostridia,36EZQ@31979|Clostridiaceae	186801|Clostridia	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
DEZH2_k127_9557285_4	931276.Cspa_c43190	6.044e-66	235.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
DEZH2_k127_9557285_3	994573.T472_0213630	3.279e-70	253.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,24ANY@186801|Clostridia,36E4X@31979|Clostridiaceae	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3,Sugar_tr
DEZH2_k127_9573622_1	768706.Desor_2360	2.198e-168	530.0	COG1878@1|root,COG1878@2|Bacteria,1TT6T@1239|Firmicutes,24CVX@186801|Clostridia	186801|Clostridia	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
DEZH2_k127_9573622_0	1304284.L21TH_1973	8.695e-170	542.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,36DVG@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the thiolase family	thlA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
DEZH2_k127_9573622_2	1511.CLOST_0198	1.823e-151	482.0	COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,248TX@186801|Clostridia	186801|Clostridia	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
DEZH2_k127_958082_0	1120746.CCNL01000017_gene3050	2.543e-174	559.0	COG0579@1|root,COG0579@2|Bacteria,2NPCR@2323|unclassified Bacteria	2|Bacteria	C	FAD dependent oxidoreductase	-	-	1.1.5.3,1.1.99.2	ko:K00109,ko:K00111,ko:K15736	ko00564,ko00650,ko01110,map00564,map00650,map01110	-	R00848,R03534	RC00029,RC00031	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
DEZH2_k127_958082_1	1120746.CCNL01000017_gene3049	2.464e-137	442.0	COG0446@1|root,COG0446@2|Bacteria,2NP2E@2323|unclassified Bacteria	2|Bacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Fer2_4,Fer2_BFD,Fer4,Pyr_redox_2,Pyr_redox_3
DEZH2_k127_9583086_1	1504981.KO116_3602	1.495e-25	106.0	COG1082@1|root,COG1082@2|Bacteria,1Q8JG@1224|Proteobacteria,1SEWD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_9583086_0	411902.CLOBOL_07005	1.062e-29	132.0	COG1879@1|root,COG1879@2|Bacteria,1UE9M@1239|Firmicutes,25J50@186801|Clostridia,2212V@1506553|Lachnoclostridium	186801|Clostridia	G	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
DEZH2_k127_9583086_2	1195236.CTER_0377	1.475e-20	94.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,3WH2F@541000|Ruminococcaceae	186801|Clostridia	G	ABC-type sugar transport system, ATPase component	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
DEZH2_k127_9589606_0	1120746.CCNL01000017_gene2805	1.174e-75	273.0	COG3459@1|root,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	ndvB	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase
DEZH2_k127_9589737_0	394503.Ccel_3454	4.77e-227	709.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,36DKN@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
DEZH2_k127_9589737_2	1487921.DP68_12495	1.187e-16	90.0	2AYHW@1|root,31QMC@2|Bacteria,1V6S7@1239|Firmicutes,24NBV@186801|Clostridia,36JKA@31979|Clostridiaceae	186801|Clostridia	S	TraX protein	-	-	-	-	-	-	-	-	-	-	-	-	TraX
DEZH2_k127_9589737_1	1392491.JIAE01000001_gene2086	2.019e-184	580.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,3WMWJ@541000|Ruminococcaceae	186801|Clostridia	D	MreB/Mbl protein	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
DEZH2_k127_9598401_2	720554.Clocl_2888	2.831e-45	166.0	COG4492@1|root,COG4492@2|Bacteria,1VAJ9@1239|Firmicutes,24MTS@186801|Clostridia,3WK80@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the UPF0735 family	pheB	-	5.4.99.5	ko:K06209	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_4
DEZH2_k127_9598401_3	469615.FGAG_00821	1.65e-19	95.0	COG0622@1|root,COG0622@2|Bacteria,37AJI@32066|Fusobacteria	32066|Fusobacteria	S	Psort location Cytoplasmic, score 8.96	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
DEZH2_k127_9598401_1	1410638.JHXJ01000007_gene1079	2.972e-58	208.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,3WIUM@541000|Ruminococcaceae	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
DEZH2_k127_9598401_0	1408823.AXUS01000002_gene978	1.885e-87	304.0	COG0500@1|root,COG0500@2|Bacteria,1UHX5@1239|Firmicutes,25E63@186801|Clostridia,25UPV@186804|Peptostreptococcaceae	186801|Clostridia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_32
DEZH2_k127_9598401_4	349161.Dred_3218	7.264e-07	58.0	COG0144@1|root,COG3270@1|root,COG0144@2|Bacteria,COG3270@2|Bacteria,1TPGQ@1239|Firmicutes,247N0@186801|Clostridia,26496@186807|Peptococcaceae	186801|Clostridia	J	PFAM Fmu (Sun) domain protein	rsmF	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI
DEZH2_k127_9599869_1	1122176.KB903541_gene283	3.298e-11	64.0	COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,1IRSG@117747|Sphingobacteriia	976|Bacteroidetes	M	PFAM Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
DEZH2_k127_9599869_0	1410638.JHXJ01000018_gene534	1.508e-147	484.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,248A4@186801|Clostridia,3WHIF@541000|Ruminococcaceae	186801|Clostridia	M	penicillin-binding protein	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
DEZH2_k127_9652103_1	411473.RUMCAL_02196	5.133e-45	167.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,3WHBA@541000|Ruminococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
DEZH2_k127_9652103_0	1121472.AQWN01000002_gene2332	1.371e-57	212.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,247UF@186801|Clostridia,260H7@186807|Peptococcaceae	186801|Clostridia	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
DEZH2_k127_9665388_0	203275.BFO_0442	3.65e-237	740.0	COG0362@1|root,COG0362@2|Bacteria,4NG05@976|Bacteroidetes,2FMFW@200643|Bacteroidia,22WS9@171551|Porphyromonadaceae	976|Bacteroidetes	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
DEZH2_k127_9665388_1	720554.Clocl_0929	2.687e-55	196.0	COG0246@1|root,COG0246@2|Bacteria,1TQ97@1239|Firmicutes,247TG@186801|Clostridia,3WGE9@541000|Ruminococcaceae	186801|Clostridia	G	Mannitol dehydrogenase	-	-	1.1.1.57	ko:K00040	ko00040,ko01100,map00040,map01100	M00061	R02454	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
DEZH2_k127_9680674_0	1469948.JPNB01000002_gene3418	7.989e-181	573.0	COG2730@1|root,COG2730@2|Bacteria,1UQKQ@1239|Firmicutes,24CUG@186801|Clostridia,36HU4@31979|Clostridiaceae	186801|Clostridia	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
DEZH2_k127_9680674_1	1469948.JPNB01000002_gene3416	4.911e-36	137.0	COG1653@1|root,COG1653@2|Bacteria,1TR5P@1239|Firmicutes,25D3R@186801|Clostridia,36JAH@31979|Clostridiaceae	186801|Clostridia	G	Domain of unknown function (DUF3502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3502,SBP_bac_1
DEZH2_k127_9737717_0	720554.Clocl_3931	2.39e-115	383.0	COG0124@1|root,COG0124@2|Bacteria,1UIUT@1239|Firmicutes,25ESP@186801|Clostridia,3WSJB@541000|Ruminococcaceae	186801|Clostridia	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
DEZH2_k127_9737717_1	1392491.JIAE01000001_gene2522	3.925e-76	258.0	COG0040@1|root,COG0040@2|Bacteria,1TSVZ@1239|Firmicutes,249AR@186801|Clostridia,3WH70@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
DEZH2_k127_9757917_0	1392491.JIAE01000001_gene1577	3.297e-145	464.0	COG0055@1|root,COG0055@2|Bacteria,1UZMA@1239|Firmicutes,24FGN@186801|Clostridia,3WREE@541000|Ruminococcaceae	186801|Clostridia	C	ATP synthase alpha/beta family, beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_ab,ATP-synt_ab_N
DEZH2_k127_9757917_1	1392491.JIAE01000001_gene1578	2.518e-80	276.0	COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia,3WHJU@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
DEZH2_k127_9788707_1	1121091.AUMP01000001_gene548	5.092e-93	321.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,4HDM0@91061|Bacilli	91061|Bacilli	E	aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
DEZH2_k127_9788707_2	1031288.AXAA01000009_gene698	1.517e-39	155.0	COG3859@1|root,COG3859@2|Bacteria,1V1WX@1239|Firmicutes,24E4Z@186801|Clostridia,36IVJ@31979|Clostridiaceae	186801|Clostridia	S	Proton-coupled thiamine transporter YuaJ	yuaJ	-	-	ko:K16789	-	-	-	-	ko00000,ko02000	2.A.88.3	-	-	Thia_YuaJ
DEZH2_k127_9788707_0	699246.HMPREF0868_0954	2.045e-154	494.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,267WW@186813|unclassified Clostridiales	186801|Clostridia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
DEZH2_k127_9792648_1	697281.Mahau_1295	1.279e-10	63.0	COG3622@1|root,COG3622@2|Bacteria,1V3V8@1239|Firmicutes,25C7T@186801|Clostridia	186801|Clostridia	G	Belongs to the hyi family	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
DEZH2_k127_9792648_2	478749.BRYFOR_05854	2.372e-09	63.0	COG3119@1|root,COG3119@2|Bacteria,1TQEP@1239|Firmicutes,2482B@186801|Clostridia	186801|Clostridia	P	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
DEZH2_k127_9792648_0	509191.AEDB02000064_gene525	2.766e-150	486.0	COG2271@1|root,COG2271@2|Bacteria,1V0WU@1239|Firmicutes,25E6S@186801|Clostridia,3WSSH@541000|Ruminococcaceae	186801|Clostridia	G	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
DEZH2_k127_9819525_3	1195236.CTER_0022	7.818e-05	50.0	COG4636@1|root,COG4636@2|Bacteria,1V4N9@1239|Firmicutes,24CZ1@186801|Clostridia,3WS1T@541000|Ruminococcaceae	186801|Clostridia	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
DEZH2_k127_9819525_2	1262914.BN533_00583	4.63e-36	139.0	COG3695@1|root,COG3695@2|Bacteria,1VC8H@1239|Firmicutes,4H8DB@909932|Negativicutes	909932|Negativicutes	H	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
DEZH2_k127_9819525_0	767817.Desgi_4059	7.791e-95	328.0	COG4632@1|root,COG5492@1|root,COG4632@2|Bacteria,COG5492@2|Bacteria,1TS8J@1239|Firmicutes,24A7I@186801|Clostridia,262NZ@186807|Peptococcaceae	186801|Clostridia	N	Leucine rich repeats (6 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,LRR_5
DEZH2_k127_9819525_1	1286171.EAL2_c06880	2.099e-94	312.0	COG1143@1|root,COG3260@1|root,COG1143@2|Bacteria,COG3260@2|Bacteria,1UHYA@1239|Firmicutes,24I1D@186801|Clostridia,25X41@186806|Eubacteriaceae	186801|Clostridia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7,Oxidored_q6
DEZH2_k127_9827611_0	521011.Mpal_1394	0.0	1103.0	COG2132@1|root,arCOG05978@1|root,arCOG03914@2157|Archaea,arCOG05978@2157|Archaea,2XUY3@28890|Euryarchaeota	28890|Euryarchaeota	Q	Multicopper	-	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
DEZH2_k127_9827611_1	398512.JQKC01000017_gene3054	3.361e-37	153.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,3WISK@541000|Ruminococcaceae	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
DEZH2_k127_9827640_0	1131462.DCF50_p2772	1.141e-289	927.0	COG1020@1|root,COG3320@1|root,COG1020@2|Bacteria,COG3320@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,260Y0@186807|Peptococcaceae	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding
DEZH2_k127_9830070_1	1321782.HMPREF1986_01451	2.78e-15	81.0	COG2384@1|root,COG2384@2|Bacteria,1V3I4@1239|Firmicutes,24BJI@186801|Clostridia,2PRVG@265975|Oribacterium	186801|Clostridia	S	tRNA (adenine(22)-N(1))-methyltransferase	trmK	-	2.1.1.217	ko:K06967	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_18,TrmK
DEZH2_k127_9830070_0	699246.HMPREF0868_0868	2.079e-165	526.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,267PJ@186813|unclassified Clostridiales	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
DEZH2_k127_9830070_2	1121335.Clst_1329	3.665e-06	57.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,3WGFW@541000|Ruminococcaceae	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
DEZH2_k127_9857428_0	1304883.KI912532_gene2787	4.337e-72	244.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,2VJTJ@28216|Betaproteobacteria,2KVI8@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the MtfA family	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
DEZH2_k127_9857428_1	640081.Dsui_2234	8.145e-66	226.0	2AN43@1|root,31D1U@2|Bacteria,1RICI@1224|Proteobacteria,2VT3P@28216|Betaproteobacteria,2KWV8@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_98632_1	1132441.KI519454_gene1033	1.446e-122	404.0	COG5512@1|root,COG5512@2|Bacteria,2HUUR@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
DEZH2_k127_98632_0	1235792.C808_03403	2.193e-131	421.0	COG2730@1|root,COG2730@2|Bacteria,1TQS6@1239|Firmicutes,24A54@186801|Clostridia,27PE2@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Putative collagen-binding domain of a collagenase	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038
DEZH2_k127_9873709_0	350688.Clos_2787	1.156e-50	186.0	COG3434@1|root,COG3434@2|Bacteria,1TPWC@1239|Firmicutes,248M1@186801|Clostridia,36ES9@31979|Clostridiaceae	186801|Clostridia	T	PFAM EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,HDOD
DEZH2_k127_9873709_1	97139.C824_00417	4.319e-36	149.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1UNTF@1239|Firmicutes,248YN@186801|Clostridia,36VGF@31979|Clostridiaceae	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
DEZH2_k127_9887027_2	1209989.TepiRe1_2467	2.994e-61	216.0	COG1695@1|root,COG1695@2|Bacteria,1V1YA@1239|Firmicutes,24H08@186801|Clostridia,42GPY@68295|Thermoanaerobacterales	186801|Clostridia	K	Domain of unknown function (DUF2703)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2703
DEZH2_k127_9887027_0	86416.Clopa_0608	6.028e-218	690.0	COG0446@1|root,COG0446@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36EYM@31979|Clostridiaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Pyr_redox_dim,Rhodanese
DEZH2_k127_9887027_5	509191.AEDB02000104_gene3829	2.629e-31	123.0	COG1146@1|root,COG1146@2|Bacteria,1VI0E@1239|Firmicutes,2490Z@186801|Clostridia,3WKTC@541000|Ruminococcaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
DEZH2_k127_9887027_3	1131462.DCF50_p224	4.238e-49	182.0	COG3118@1|root,COG3118@2|Bacteria,1V2UU@1239|Firmicutes,24GCR@186801|Clostridia	186801|Clostridia	O	Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
DEZH2_k127_9887027_1	509191.AEDB02000104_gene3831	8.671e-95	316.0	COG4232@1|root,COG4232@2|Bacteria,1V9UQ@1239|Firmicutes,24DK4@186801|Clostridia,3WJGE@541000|Ruminococcaceae	186801|Clostridia	CO	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD,Thioredoxin
DEZH2_k127_9887027_4	2325.TKV_c19530	1.598e-47	173.0	COG1146@1|root,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	fdxB	-	1.17.1.1,1.2.7.3	ko:K00176,ko:K00523	ko00020,ko00520,ko00720,ko01100,ko01120,ko01200,map00020,map00520,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197,R03391,R03392	RC00004,RC00230,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_21,Fer4_4,Fer4_6,Fer4_7
DEZH2_k127_988747_3	1282887.AUJG01000002_gene1074	0.0002677	44.0	COG0828@1|root,COG0828@2|Bacteria,1VEHU@1239|Firmicutes,24QP9@186801|Clostridia	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
DEZH2_k127_988747_1	1408311.JNJM01000019_gene1856	2.557e-30	134.0	COG0738@1|root,COG0738@2|Bacteria,1UZWI@1239|Firmicutes,24H3U@186801|Clostridia,2PT5S@265975|Oribacterium	186801|Clostridia	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DEZH2_k127_988747_0	203119.Cthe_0665	2.365e-97	328.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,24AF9@186801|Clostridia,3WNDD@541000|Ruminococcaceae	186801|Clostridia	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
DEZH2_k127_9901228_2	350688.Clos_2048	1.159e-162	522.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,36E9C@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
DEZH2_k127_9901228_9	1480694.DC28_01520	4.062e-17	83.0	COG2608@1|root,COG2608@2|Bacteria,2JB2Q@203691|Spirochaetes	203691|Spirochaetes	P	Heavy-metal-associated domain	-	-	-	-	-	-	-	-	-	-	-	-	HMA
DEZH2_k127_9901228_7	290402.Cbei_2278	3.872e-32	128.0	COG4309@1|root,COG4309@2|Bacteria,1VHYE@1239|Firmicutes,24RCX@186801|Clostridia,36KND@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249,Hemerythrin
DEZH2_k127_9901228_3	138119.DSY0184	3.086e-146	475.0	COG1373@1|root,COG1373@2|Bacteria,1TQ8Z@1239|Firmicutes,24A83@186801|Clostridia,2606C@186807|Peptococcaceae	186801|Clostridia	S	AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
DEZH2_k127_9901228_0	1232453.BAIF02000079_gene92	1.323e-180	571.0	COG0407@1|root,COG0407@2|Bacteria,1TS5A@1239|Firmicutes,24F2K@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DEZH2_k127_9901228_10	1499689.CCNN01000006_gene365	1.893e-07	62.0	COG2755@1|root,COG2755@2|Bacteria,1VDE2@1239|Firmicutes,24N6X@186801|Clostridia,36JHN@31979|Clostridiaceae	186801|Clostridia	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
DEZH2_k127_9901228_6	1293054.HSACCH_00893	3.827e-50	192.0	COG4952@1|root,COG4952@2|Bacteria,1UD8H@1239|Firmicutes,24HDU@186801|Clostridia,3WBZR@53433|Halanaerobiales	186801|Clostridia	M	Xylose isomerase-like TIM barrel	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
DEZH2_k127_9901228_1	556261.HMPREF0240_00556	7.55e-169	543.0	COG1070@1|root,COG1070@2|Bacteria,1TP7Z@1239|Firmicutes,247ZU@186801|Clostridia,36FYV@31979|Clostridiaceae	186801|Clostridia	G	Carbohydrate kinase	rhaB	-	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
DEZH2_k127_9901228_8	1232453.BAIF02000079_gene93	1.97e-31	126.0	COG3254@1|root,COG3254@2|Bacteria	2|Bacteria	S	rhamnose metabolic process	-	-	5.1.3.32	ko:K03534	-	-	R10819	RC00563	ko00000,ko01000	-	-	-	rhaM
DEZH2_k127_9901228_5	1347087.CBYO010000014_gene2426	8.593e-55	204.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,4H9NG@91061|Bacilli	91061|Bacilli	K	Catabolite control protein A	ccpA	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
DEZH2_k127_9901228_4	556261.HMPREF0240_02654	1.36e-93	320.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DEZH2_k127_9903860_0	411460.RUMTOR_00339	1.76e-257	803.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,3XZ6P@572511|Blautia	186801|Clostridia	C	Psort location Cytoplasmic, score 9.98	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
DEZH2_k127_9903860_3	445972.ANACOL_03972	9.412e-54	194.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24HFB@186801|Clostridia,3WISW@541000|Ruminococcaceae	186801|Clostridia	C	NADH-quinone oxidoreductase, E subunit	nuoE	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00334,ko:K18330,ko:K22340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
DEZH2_k127_9903860_2	1392491.JIAE01000001_gene1207	8.424e-61	220.0	COG0564@1|root,COG0564@2|Bacteria,1TS1T@1239|Firmicutes,249AH@186801|Clostridia,3WI75@541000|Ruminococcaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD_2	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
DEZH2_k127_9903860_1	394503.Ccel_1896	3.251e-78	274.0	COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia,36E7M@31979|Clostridiaceae	186801|Clostridia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
DEZH2_k127_9968052_0	1195236.CTER_5288	1.365e-147	472.0	COG3875@1|root,COG3875@2|Bacteria,1UYM4@1239|Firmicutes,24AR5@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
DEZH2_k127_9968052_1	1226325.HMPREF1548_01452	2.254e-73	251.0	COG0673@1|root,COG0673@2|Bacteria,1U4A4@1239|Firmicutes,249UF@186801|Clostridia,36FXW@31979|Clostridiaceae	186801|Clostridia	E	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_9992334_5	1449063.JMLS01000014_gene1663	1.098e-53	214.0	COG2207@1|root,COG2207@2|Bacteria,1V029@1239|Firmicutes,4HE2K@91061|Bacilli,26QS8@186822|Paenibacillaceae	91061|Bacilli	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,dCache_1
DEZH2_k127_9992334_4	1226325.HMPREF1548_01303	2.812e-64	241.0	COG1653@1|root,COG1653@2|Bacteria,1U4VB@1239|Firmicutes,24ZEC@186801|Clostridia	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
DEZH2_k127_9992334_2	697281.Mahau_1290	1.785e-93	317.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,248XU@186801|Clostridia,42ET3@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
DEZH2_k127_9992334_3	658086.HMPREF0994_05558	1.054e-85	292.0	COG0395@1|root,COG0395@2|Bacteria,1TQ9F@1239|Firmicutes,24Y0E@186801|Clostridia	186801|Clostridia	U	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
DEZH2_k127_9992334_1	445974.CLORAM_01674	9.984e-101	345.0	COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,3VQ3H@526524|Erysipelotrichia	526524|Erysipelotrichia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
DEZH2_k127_9992334_6	1408424.JHYI01000007_gene1497	9.729e-09	66.0	COG2508@1|root,COG2508@2|Bacteria,1TRRH@1239|Firmicutes,4HDGP@91061|Bacilli,1ZB6S@1386|Bacillus	91061|Bacilli	QT	Transcriptional regulator	yukF	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032502,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043934,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	-	-	-	-	-	-	-	-	-	CodY,HTH_30
DEZH2_k127_9992334_0	1449050.JNLE01000003_gene2522	9.053e-117	422.0	COG1472@1|root,COG1472@2|Bacteria,1TPH5@1239|Firmicutes,247QP@186801|Clostridia,36F70@31979|Clostridiaceae	186801|Clostridia	G	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
## 2454 queries scanned
## Total time (seconds): 4.6442975997924805
## Rate: 528.39 q/s