## Sat Dec 13 08:10:04 2025
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/qs/new/DEZH2_bin.9.fa -m mmseqs --itype genome -o DEZH2_bin.9 --output_dir /data/result/bins/wyx/egg/DEZH2_bin.9 --cpu 32
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
DEZH2_k127_10115974_2	401526.TcarDRAFT_1695	8.344e-12	67.0	COG0323@1|root,COG0323@2|Bacteria,1UK25@1239|Firmicutes,4H4HN@909932|Negativicutes	909932|Negativicutes	L	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
DEZH2_k127_10115974_1	720554.Clocl_1311	4.436e-39	149.0	COG3411@1|root,COG3411@2|Bacteria,1V6DT@1239|Firmicutes,24M31@186801|Clostridia,3WJGK@541000|Ruminococcaceae	186801|Clostridia	C	Ferredoxin	-	-	1.12.1.3	ko:K17992	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx
DEZH2_k127_10115974_0	1410638.JHXJ01000002_gene1414	1.843e-156	499.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,3WG9F@541000|Ruminococcaceae	186801|Clostridia	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
DEZH2_k127_10146406_0	272562.CA_C0847	2.506e-65	244.0	COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,36DVM@31979|Clostridiaceae	186801|Clostridia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
DEZH2_k127_10146406_1	1121344.JHZO01000007_gene2101	3.249e-49	181.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
DEZH2_k127_10176281_5	931626.Awo_c04180	1.94e-30	121.0	COG1876@1|root,COG1876@2|Bacteria,1V1F7@1239|Firmicutes,24E6R@186801|Clostridia,25WI1@186806|Eubacteriaceae	186801|Clostridia	M	D-alanyl-D-alanine carboxypeptidase	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	DUF348,G5,VanY
DEZH2_k127_10176281_7	1121335.Clst_1496	3.145e-20	91.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,24XP2@186801|Clostridia,3WN9Y@541000|Ruminococcaceae	186801|Clostridia	E	LeuA allosteric (dimerisation) domain	-	-	2.3.1.182	ko:K09011	ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230	M00535	R07399	RC00004,RC01205	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
DEZH2_k127_10176281_0	1121335.Clst_1496	4.612e-201	634.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,24XP2@186801|Clostridia,3WN9Y@541000|Ruminococcaceae	186801|Clostridia	E	LeuA allosteric (dimerisation) domain	-	-	2.3.1.182	ko:K09011	ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230	M00535	R07399	RC00004,RC01205	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
DEZH2_k127_10176281_8	491915.Aflv_0337	2.188e-14	75.0	2DIGD@1|root,30377@2|Bacteria,1VETT@1239|Firmicutes,4HPP2@91061|Bacilli,21X7Z@150247|Anoxybacillus	91061|Bacilli	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
DEZH2_k127_10176281_4	913865.DOT_1500	8.405e-60	212.0	COG2128@1|root,COG2128@2|Bacteria,1V55P@1239|Firmicutes,24HT6@186801|Clostridia	186801|Clostridia	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
DEZH2_k127_10176281_6	693746.OBV_14630	3.273e-26	113.0	COG0735@1|root,COG0735@2|Bacteria,1V6RI@1239|Firmicutes,24HRQ@186801|Clostridia	186801|Clostridia	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
DEZH2_k127_10176281_2	138119.DSY0105	8.123e-94	318.0	COG1108@1|root,COG1108@2|Bacteria,1TR79@1239|Firmicutes,24875@186801|Clostridia,261UN@186807|Peptococcaceae	186801|Clostridia	P	ABC-type Mn2 Zn2 transport	adcB	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
DEZH2_k127_10176281_3	138119.DSY0104	9.29e-62	222.0	COG1121@1|root,COG1121@2|Bacteria,1TQ68@1239|Firmicutes,248F1@186801|Clostridia,264QE@186807|Peptococcaceae	186801|Clostridia	P	ATPases associated with a variety of cellular activities	zurA	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
DEZH2_k127_10176281_1	610130.Closa_4175	7.006e-103	344.0	COG0803@1|root,COG0803@2|Bacteria,1TPG7@1239|Firmicutes,249VZ@186801|Clostridia,21ZGW@1506553|Lachnoclostridium	186801|Clostridia	P	Zinc-uptake complex component A periplasmic	adcA	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
DEZH2_k127_10176281_9	573063.Metin_0418	1.93e-13	72.0	COG1321@1|root,arCOG02100@2157|Archaea,2XZV0@28890|Euryarchaeota	28890|Euryarchaeota	K	PFAM iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
DEZH2_k127_10183230_0	1392491.JIAE01000001_gene2462	5.243e-130	420.0	COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,247NY@186801|Clostridia,3WGKF@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C,QRPTase_N
DEZH2_k127_10183230_1	500633.CLOHIR_01696	4.042e-74	252.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,247XN@186801|Clostridia,25QFB@186804|Peptostreptococcaceae	186801|Clostridia	G	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
DEZH2_k127_10183230_2	1392491.JIAE01000001_gene2456	3.825e-35	136.0	COG0463@1|root,COG0463@2|Bacteria,1TPR3@1239|Firmicutes,248Q5@186801|Clostridia,3WH4D@541000|Ruminococcaceae	186801|Clostridia	M	Glycosyltransferase like family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
DEZH2_k127_10187183_2	1392491.JIAE01000001_gene1357	2.711e-56	205.0	COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,24848@186801|Clostridia,3WGW3@541000|Ruminococcaceae	186801|Clostridia	F	pyrimidine-nucleoside phosphorylase	pdp	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08925	Glycos_trans_3N,Glycos_transf_3,PYNP_C
DEZH2_k127_10187183_1	699246.HMPREF0868_0918	2.281e-60	213.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,268AF@186813|unclassified Clostridiales	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
DEZH2_k127_10187183_3	1392491.JIAE01000001_gene1359	2.017e-46	174.0	COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia,3WIM6@541000|Ruminococcaceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
DEZH2_k127_10187183_0	1392491.JIAE01000001_gene1360	4.199e-160	512.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,3WMVT@541000|Ruminococcaceae	186801|Clostridia	L	Holliday junction DNA helicase ruvB C-terminus	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
DEZH2_k127_10187183_4	699246.HMPREF0868_0915	1.444e-11	67.0	COG1636@1|root,COG1636@2|Bacteria,1TT7H@1239|Firmicutes,248EA@186801|Clostridia	186801|Clostridia	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
DEZH2_k127_10201072_2	768704.Desmer_1341	6.522e-66	231.0	COG1835@1|root,COG1835@2|Bacteria,1V7CG@1239|Firmicutes,24WKR@186801|Clostridia,263B9@186807|Peptococcaceae	186801|Clostridia	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
DEZH2_k127_10201072_1	1304866.K413DRAFT_4299	4.378e-100	336.0	COG2931@1|root,COG2931@2|Bacteria,1TSGB@1239|Firmicutes,247TS@186801|Clostridia,36F14@31979|Clostridiaceae	186801|Clostridia	Q	PFAM Collagen triple helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	Collagen
DEZH2_k127_10201072_3	1410617.JHXH01000005_gene951	3.953e-21	94.0	COG0778@1|root,COG0778@2|Bacteria,1V9VR@1239|Firmicutes,24Q35@186801|Clostridia,3WJQ2@541000|Ruminococcaceae	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DEZH2_k127_10201072_0	398512.JQKC01000067_gene4262	0.0	1643.0	COG0515@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,1UK1R@1239|Firmicutes,25FHG@186801|Clostridia	186801|Clostridia	KLT	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,Pkinase
DEZH2_k127_10229563_1	1160721.RBI_I01031	2.059e-83	279.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,3WGUF@541000|Ruminococcaceae	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
DEZH2_k127_10229563_0	720554.Clocl_2193	1.815e-83	284.0	COG3442@1|root,COG3442@2|Bacteria,1U7I9@1239|Firmicutes,24A80@186801|Clostridia,3WHHU@541000|Ruminococcaceae	186801|Clostridia	S	glutamine amidotransferase	-	-	-	ko:K07009	-	-	-	-	ko00000	-	-	-	GATase_3
DEZH2_k127_10229563_2	1392491.JIAE01000001_gene93	1.927e-67	236.0	COG0771@1|root,COG0771@2|Bacteria,1UHPI@1239|Firmicutes,25E9J@186801|Clostridia,3WSID@541000|Ruminococcaceae	186801|Clostridia	M	Mur ligase middle domain	murE2	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	DUF1727,Mur_ligase_M
DEZH2_k127_10277152_0	1392491.JIAE01000001_gene678	1.957e-77	275.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3WSQQ@541000|Ruminococcaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
DEZH2_k127_10277152_2	1410638.JHXJ01000027_gene1172	3.763e-21	94.0	COG2846@1|root,COG2846@2|Bacteria,1UEHU@1239|Firmicutes,25N9M@186801|Clostridia,3WKIH@541000|Ruminococcaceae	186801|Clostridia	D	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
DEZH2_k127_10277152_1	720554.Clocl_3294	6.604e-30	121.0	COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia,3WKJ9@541000|Ruminococcaceae	186801|Clostridia	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
DEZH2_k127_10284951_0	1392491.JIAE01000001_gene1463	1.929e-227	716.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia,3WGCZ@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,HTH_18,LeuA_dimer
DEZH2_k127_10289633_1	545696.HOLDEFILI_00637	8.915e-112	366.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,3VNW3@526524|Erysipelotrichia	526524|Erysipelotrichia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
DEZH2_k127_10289633_0	935948.KE386495_gene1271	1.15e-272	847.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia,42FWA@68295|Thermoanaerobacterales	186801|Clostridia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
DEZH2_k127_10297264_0	556261.HMPREF0240_01321	3.508e-121	397.0	COG0591@1|root,COG0591@2|Bacteria,1TPVE@1239|Firmicutes,248NQ@186801|Clostridia,36FNJ@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307,ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21,2.A.21.2	-	-	SSF
DEZH2_k127_10297264_1	1392491.JIAE01000001_gene1597	1.943e-109	365.0	COG1645@1|root,COG1645@2|Bacteria,1TRYG@1239|Firmicutes,25F3V@186801|Clostridia,3WP88@541000|Ruminococcaceae	186801|Clostridia	S	bacterial-type flagellum-dependent swarming motility	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10297264_2	1392491.JIAE01000001_gene1598	7.412e-98	330.0	COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia,3WGCV@541000|Ruminococcaceae	186801|Clostridia	G	Alpha amylase, catalytic domain protein	apu	-	2.4.1.25,3.2.1.133,3.2.1.135,3.2.1.20,3.2.1.54	ko:K00705,ko:K01187,ko:K01208	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R02112,R03122,R05196,R06087,R06088,R11262	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH13,GH31,GH77	-	Alpha-amylase,Alpha-amylase_N,Glyco_hydro_77,Malt_amylase_C
DEZH2_k127_10300011_6	1274374.CBLK010000079_gene4009	1.85e-20	93.0	COG0500@1|root,COG2267@1|root,COG2226@2|Bacteria,COG2267@2|Bacteria,1TR4J@1239|Firmicutes	1239|Firmicutes	Q	belongs to the nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10300011_3	357809.Cphy_1840	1.706e-56	202.0	COG0655@1|root,COG0655@2|Bacteria,1UG6S@1239|Firmicutes,24IAG@186801|Clostridia	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DEZH2_k127_10300011_2	357809.Cphy_1841	7.039e-79	269.0	COG2249@1|root,COG2249@2|Bacteria,1VDDN@1239|Firmicutes,24E80@186801|Clostridia	186801|Clostridia	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DEZH2_k127_10300011_1	1226325.HMPREF1548_02518	1.043e-99	333.0	2B89V@1|root,321IF@2|Bacteria,1UEI7@1239|Firmicutes,24AND@186801|Clostridia,36IZA@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10300011_5	1280689.AUJC01000008_gene3002	4.606e-33	138.0	COG0789@1|root,COG0789@2|Bacteria,1VEB9@1239|Firmicutes,249NR@186801|Clostridia,36DBZ@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
DEZH2_k127_10300011_4	273068.TTE2628	1.835e-34	141.0	COG1878@1|root,COG1878@2|Bacteria,1TSXB@1239|Firmicutes,24B80@186801|Clostridia,42GR0@68295|Thermoanaerobacterales	186801|Clostridia	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
DEZH2_k127_10300011_0	699246.HMPREF0868_0408	3.862e-119	391.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,267QU@186813|unclassified Clostridiales	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
DEZH2_k127_10301230_2	398512.JQKC01000027_gene3921	2.165e-11	66.0	COG0641@1|root,COG0641@2|Bacteria,1V5ZZ@1239|Firmicutes,24IY0@186801|Clostridia,3WRPY@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM superfamily	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
DEZH2_k127_10301230_3	679201.HMPREF9334_02007	9.764e-05	46.0	COG0641@1|root,COG0641@2|Bacteria,1V0HK@1239|Firmicutes,4H3A4@909932|Negativicutes	909932|Negativicutes	C	Radical SAM domain protein	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
DEZH2_k127_10301230_1	398512.JQKC01000027_gene3920	3.705e-35	144.0	2F6FK@1|root,33YYQ@2|Bacteria,1VXUU@1239|Firmicutes,251W9@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10301230_0	398512.JQKC01000011_gene309	4.134e-41	152.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,3WGK9@541000|Ruminococcaceae	186801|Clostridia	G	Glycosyltransferase family 36	-	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	Glyco_hydro_36,Glyco_transf_36
DEZH2_k127_10342226_2	180332.JTGN01000003_gene2075	2.505e-32	130.0	COG0526@1|root,COG0607@1|root,COG0526@2|Bacteria,COG0607@2|Bacteria,1U0PW@1239|Firmicutes,24RKU@186801|Clostridia	186801|Clostridia	P	Rhodanese-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
DEZH2_k127_10342226_1	515635.Dtur_0291	5.303e-64	230.0	COG0679@1|root,COG0679@2|Bacteria	2|Bacteria	S	auxin-activated signaling pathway	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
DEZH2_k127_10342226_0	293826.Amet_2172	4.312e-95	322.0	COG2199@1|root,COG3829@1|root,COG3706@2|Bacteria,COG3829@2|Bacteria,1VB8N@1239|Firmicutes,25EJ3@186801|Clostridia	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
DEZH2_k127_10342226_3	1340493.JNIF01000004_gene920	3.366e-12	69.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5
DEZH2_k127_10344376_0	1410638.JHXJ01000002_gene1330	8.14e-135	435.0	COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,3WHC9@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the aspartokinase family	thrA	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
DEZH2_k127_10344376_4	1392491.JIAE01000001_gene1444	2.385e-97	339.0	COG0631@1|root,COG0631@2|Bacteria	2|Bacteria	T	protein serine/threonine phosphatase activity	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2,Pkinase
DEZH2_k127_10344376_1	1392491.JIAE01000001_gene1445	5.752e-105	353.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,248RH@186801|Clostridia,3WGW9@541000|Ruminococcaceae	186801|Clostridia	K	Cell envelope-like function transcriptional attenuator common domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
DEZH2_k127_10344376_2	1392491.JIAE01000001_gene1446	1.875e-102	347.0	COG1470@1|root,COG1470@2|Bacteria,1TRGE@1239|Firmicutes,24EHG@186801|Clostridia,3WJFN@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
DEZH2_k127_10344376_6	1410638.JHXJ01000013_gene2338	1.422e-23	108.0	COG5652@1|root,COG5652@2|Bacteria,1VF6Q@1239|Firmicutes	1239|Firmicutes	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
DEZH2_k127_10344376_5	1410638.JHXJ01000013_gene2337	8.706e-66	227.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,3WIZR@541000|Ruminococcaceae	186801|Clostridia	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
DEZH2_k127_10344376_3	1392491.JIAE01000001_gene1412	9.04e-102	337.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,3WGP5@541000|Ruminococcaceae	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
DEZH2_k127_10346678_0	1408437.JNJN01000028_gene1350	9.177e-225	703.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,25UY5@186806|Eubacteriaceae	186801|Clostridia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.2,1.4.1.3,1.4.1.4	ko:K00260,ko:K00261,ko:K00262	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
DEZH2_k127_10346678_1	1499967.BAYZ01000090_gene4936	3.568e-32	138.0	COG0823@1|root,COG0823@2|Bacteria,2NPHZ@2323|unclassified Bacteria	2|Bacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
DEZH2_k127_10373388_0	1392491.JIAE01000001_gene1386	0.0	1185.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,3WGPN@541000|Ruminococcaceae	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
DEZH2_k127_10373388_2	720554.Clocl_2609	2.31e-35	136.0	COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,24MX9@186801|Clostridia,3WKB9@541000|Ruminococcaceae	186801|Clostridia	S	protein, YerC YecD	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
DEZH2_k127_10373388_1	699246.HMPREF0868_1092	5.475e-36	150.0	2DS1R@1|root,33E5E@2|Bacteria,1VPWK@1239|Firmicutes,25BVN@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10375398_3	180332.JTGN01000024_gene1690	2.019e-34	140.0	COG1595@1|root,COG1595@2|Bacteria,1V6UV@1239|Firmicutes,24JUJ@186801|Clostridia	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DEZH2_k127_10375398_2	1292035.H476_1538	2.638e-37	149.0	28KWE@1|root,2ZACM@2|Bacteria,1UQRE@1239|Firmicutes,24RME@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N,zinc_ribbon_2
DEZH2_k127_10375398_5	1173022.Cri9333_1611	3.602e-10	70.0	2AYHW@1|root,31QMC@2|Bacteria,1G645@1117|Cyanobacteria,1HDE0@1150|Oscillatoriales	1117|Cyanobacteria	S	TraX protein	-	-	-	-	-	-	-	-	-	-	-	-	TraX
DEZH2_k127_10375398_0	1392491.JIAE01000001_gene2086	4.716e-195	610.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,3WMWJ@541000|Ruminococcaceae	186801|Clostridia	D	MreB/Mbl protein	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
DEZH2_k127_10375398_1	411467.BACCAP_00367	1.277e-98	327.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,268NY@186813|unclassified Clostridiales	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_10375398_4	478749.BRYFOR_08334	8.902e-32	131.0	COG0577@1|root,COG1511@1|root,COG0577@2|Bacteria,COG1511@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia	186801|Clostridia	V	Efflux ABC transporter, permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DEZH2_k127_10377984_2	1408321.JNJD01000009_gene1689	7.592e-42	169.0	COG3290@1|root,COG3290@2|Bacteria,1VFJZ@1239|Firmicutes,25BV0@186801|Clostridia,27U0R@186928|unclassified Lachnospiraceae	186801|Clostridia	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_5
DEZH2_k127_10377984_1	1280664.AUIX01000001_gene737	6.825e-71	247.0	COG3279@1|root,COG3279@2|Bacteria,1V9YY@1239|Firmicutes,24SZ9@186801|Clostridia,4C0AQ@830|Butyrivibrio	186801|Clostridia	T	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
DEZH2_k127_10377984_0	1410630.JNKP01000004_gene442	2.426e-99	329.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,27M7K@186928|unclassified Lachnospiraceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_10377984_3	877411.JMMA01000002_gene1963	6.834e-19	89.0	COG0577@1|root,COG0577@2|Bacteria,1TRE5@1239|Firmicutes,24CGY@186801|Clostridia,3WGXH@541000|Ruminococcaceae	186801|Clostridia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
DEZH2_k127_10379420_3	1280685.AUKC01000056_gene2566	3.02e-36	138.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,4BXBZ@830|Butyrivibrio	186801|Clostridia	S	ABC transporter	yfmM	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
DEZH2_k127_10379420_0	158189.SpiBuddy_2706	1.908e-117	388.0	COG5012@1|root,COG5012@2|Bacteria,2JB15@203691|Spirochaetes	203691|Spirochaetes	K	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding
DEZH2_k127_10379420_2	1511.CLOST_0399	9.878e-80	278.0	COG5001@1|root,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4,Phosphonate-bd
DEZH2_k127_10379420_1	1123511.KB905859_gene2200	1.263e-111	363.0	COG2267@1|root,COG2267@2|Bacteria,1TPI0@1239|Firmicutes,4H3TE@909932|Negativicutes	909932|Negativicutes	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
DEZH2_k127_10394406_3	357809.Cphy_3211	1.892e-77	269.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UYCG@1239|Firmicutes,24DKG@186801|Clostridia	186801|Clostridia	T	helix-turn-helix- domain containing protein, AraC type	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
DEZH2_k127_10394406_0	357809.Cphy_3210	6.793e-234	735.0	COG1653@1|root,COG1653@2|Bacteria,1TQWF@1239|Firmicutes,24CWD@186801|Clostridia	186801|Clostridia	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1,SBP_bac_8
DEZH2_k127_10394406_1	357809.Cphy_3209	3.325e-129	422.0	COG4209@1|root,COG4209@2|Bacteria,1TQ64@1239|Firmicutes,24YP3@186801|Clostridia	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
DEZH2_k127_10394406_2	357809.Cphy_3208	9.902e-117	384.0	COG0395@1|root,COG0395@2|Bacteria,1TP14@1239|Firmicutes,2481Z@186801|Clostridia,222S9@1506553|Lachnoclostridium	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
DEZH2_k127_10428160_3	1410638.JHXJ01000010_gene117	4.737e-15	76.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3WGK8@541000|Ruminococcaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
DEZH2_k127_10428160_0	1410638.JHXJ01000010_gene117	1.102e-185	594.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3WGK8@541000|Ruminococcaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
DEZH2_k127_10428160_2	398512.JQKC01000008_gene990	4.554e-58	211.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,3WJ4X@541000|Ruminococcaceae	186801|Clostridia	T	serine threonine protein phosphatase	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
DEZH2_k127_10428160_1	1392491.JIAE01000001_gene1053	1.583e-98	327.0	COG0820@1|root,COG0820@2|Bacteria,1TPVF@1239|Firmicutes,248BC@186801|Clostridia,3WGYF@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
DEZH2_k127_10440789_1	720554.Clocl_4061	8.072e-99	328.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,3WG9H@541000|Ruminococcaceae	186801|Clostridia	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DEZH2_k127_10440789_2	1345695.CLSA_c02700	7.496e-71	243.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,36I0J@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35,4.2.1.85	ko:K01704,ko:K20453	ko00290,ko00660,ko00760,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map01100,map01110,map01120,map01210,map01230	M00432,M00535	R03069,R03896,R03898,R03968,R04001,R10170	RC00843,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
DEZH2_k127_10440789_0	1392491.JIAE01000001_gene1796	7.02e-187	593.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,3WG9G@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35,4.2.1.85	ko:K01703,ko:K20452	ko00290,ko00660,ko00760,ko00966,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map00966,map01100,map01110,map01120,map01210,map01230	M00432,M00535	R03069,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00843,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04465	Aconitase
DEZH2_k127_10440789_3	1105031.HMPREF1141_2895	9.436e-49	181.0	COG1825@1|root,COG1825@2|Bacteria,1VA38@1239|Firmicutes,24N24@186801|Clostridia,36MC3@31979|Clostridiaceae	186801|Clostridia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
DEZH2_k127_10440789_4	1469948.JPNB01000001_gene636	4.273e-45	174.0	COG0300@1|root,COG0300@2|Bacteria,1UZHA@1239|Firmicutes,248C8@186801|Clostridia,36IDY@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
DEZH2_k127_10440789_5	485916.Dtox_3051	1.497e-05	53.0	COG1846@1|root,COG1846@2|Bacteria,1V6HZ@1239|Firmicutes,24EYW@186801|Clostridia	186801|Clostridia	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR
DEZH2_k127_10454652_4	720554.Clocl_0501	3.879e-25	109.0	COG4976@1|root,COG4976@2|Bacteria,1UHZM@1239|Firmicutes,24A6U@186801|Clostridia,3WSIZ@541000|Ruminococcaceae	186801|Clostridia	S	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
DEZH2_k127_10454652_3	1410638.JHXJ01000008_gene372	4.813e-88	306.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,3WGCB@541000|Ruminococcaceae	186801|Clostridia	D	Peptidase, M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
DEZH2_k127_10454652_1	1392491.JIAE01000001_gene510	1.15e-110	365.0	COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia,3WHNT@541000|Ruminococcaceae	186801|Clostridia	D	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
DEZH2_k127_10454652_2	1392491.JIAE01000001_gene509	1.653e-102	338.0	COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,3WGK4@541000|Ruminococcaceae	186801|Clostridia	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
DEZH2_k127_10454652_0	1392491.JIAE01000001_gene508	9.802e-130	423.0	COG3835@1|root,COG3835@2|Bacteria,1TQWD@1239|Firmicutes,24ZMW@186801|Clostridia,3WHDV@541000|Ruminococcaceae	186801|Clostridia	KT	Psort location Cytoplasmic, score	-	-	-	ko:K02647	-	-	-	-	ko00000,ko03000	-	-	-	HTH_30
DEZH2_k127_10454652_5	1392491.JIAE01000001_gene507	1.59e-12	67.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3WGC7@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	msmX	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
DEZH2_k127_10460496_1	1185653.A1A1_05752	8.072e-82	298.0	COG1948@1|root,COG4880@2|Bacteria,1TQK0@1239|Firmicutes,4H9YF@91061|Bacilli,26DPW@186818|Planococcaceae	91061|Bacilli	L	Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel,Big_5,Cu_amine_oxidN1
DEZH2_k127_10460496_0	1392491.JIAE01000001_gene2536	8.161e-98	327.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,3WIRQ@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
DEZH2_k127_10460496_2	33035.JPJF01000072_gene4361	1.074e-28	117.0	COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,3XYJA@572511|Blautia	186801|Clostridia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
DEZH2_k127_10481569_0	1392491.JIAE01000001_gene1436	6.607e-129	419.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,3WH5J@541000|Ruminococcaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
DEZH2_k127_10481569_4	203119.Cthe_0769	3.788e-40	149.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia,3WJSQ@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
DEZH2_k127_10481569_6	1392491.JIAE01000001_gene1434	9.088e-28	114.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,3WKWP@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
DEZH2_k127_10481569_5	1392491.JIAE01000001_gene1433	5.066e-36	143.0	COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia,3WIMH@541000|Ruminococcaceae	186801|Clostridia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
DEZH2_k127_10481569_1	1410638.JHXJ01000030_gene305	1.075e-79	273.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,247JF@186801|Clostridia,3WH8Z@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
DEZH2_k127_10481569_3	1392491.JIAE01000001_gene1431	3.186e-51	184.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia,3WPU9@541000|Ruminococcaceae	186801|Clostridia	J	Ribosomal protein L19	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
DEZH2_k127_10481569_2	1410638.JHXJ01000030_gene307	5.229e-75	259.0	COG1161@1|root,COG1161@2|Bacteria,1TQGK@1239|Firmicutes,2490H@186801|Clostridia,3WGB7@541000|Ruminococcaceae	186801|Clostridia	S	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity	ylqF	-	-	ko:K14540	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1
DEZH2_k127_10482568_1	33035.JPJF01000018_gene4341	4.673e-116	386.0	COG1668@1|root,COG1668@2|Bacteria,1TXRK@1239|Firmicutes,248YS@186801|Clostridia,3Y1AQ@572511|Blautia	186801|Clostridia	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
DEZH2_k127_10482568_0	33035.JPJF01000018_gene4342	2.999e-119	390.0	COG4152@1|root,COG4152@2|Bacteria,1TR06@1239|Firmicutes,249YC@186801|Clostridia,3Y10M@572511|Blautia	186801|Clostridia	S	Domain of unknown function (DUF4162)	natA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DEZH2_k127_10482568_2	903814.ELI_1347	1.866e-72	249.0	COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24FQH@186801|Clostridia,25ZGM@186806|Eubacteriaceae	186801|Clostridia	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
DEZH2_k127_10482568_3	583355.Caka_2394	1.077e-05	50.0	COG0115@1|root,COG0115@2|Bacteria,46W1F@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Amino-transferase class IV	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_4
DEZH2_k127_10511441_3	572479.Hprae_1145	5.563e-05	57.0	COG1361@1|root,COG1404@1|root,COG2356@1|root,COG3409@1|root,COG4625@1|root,COG4886@1|root,COG5492@1|root,COG1361@2|Bacteria,COG1404@2|Bacteria,COG2356@2|Bacteria,COG3409@2|Bacteria,COG4625@2|Bacteria,COG4886@2|Bacteria,COG5492@2|Bacteria,1V3UH@1239|Firmicutes,24K2H@186801|Clostridia	186801|Clostridia	E	leucine-rich repeat-containing protein typical subtype	-	-	-	-	-	-	-	-	-	-	-	-	DUF3888,FIVAR,LRR_4
DEZH2_k127_10511441_2	1246484.D479_19433	9.133e-18	89.0	2F3TG@1|root,33WJV@2|Bacteria,1VWIG@1239|Firmicutes,4HWKU@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10511441_1	645991.Sgly_1312	5.665e-28	113.0	COG1476@1|root,COG1476@2|Bacteria,1VERT@1239|Firmicutes,24QJJ@186801|Clostridia,2660Z@186807|Peptococcaceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
DEZH2_k127_10511441_0	929506.CbC4_1709	1.647e-49	186.0	COG4886@1|root,COG4886@2|Bacteria,1VZHN@1239|Firmicutes,251N6@186801|Clostridia	186801|Clostridia	S	Leucine-rich repeat (LRR) protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10517286_1	1410638.JHXJ01000027_gene1191	4.312e-142	470.0	COG5427@1|root,COG5427@2|Bacteria,1UY7V@1239|Firmicutes,24BA0@186801|Clostridia,3WHM2@541000|Ruminococcaceae	186801|Clostridia	S	Uncharacterized membrane protein (DUF2298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298
DEZH2_k127_10517286_0	1410638.JHXJ01000027_gene1194	7.46e-212	672.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
DEZH2_k127_10517286_2	1392491.JIAE01000001_gene622	5.276e-108	380.0	COG0631@1|root,COG0631@2|Bacteria,1VW2C@1239|Firmicutes,251FU@186801|Clostridia	186801|Clostridia	T	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10517286_3	411470.RUMGNA_03864	0.0005102	43.0	COG4805@1|root,COG4805@2|Bacteria,1TREN@1239|Firmicutes,249U9@186801|Clostridia,3XYKE@572511|Blautia	186801|Clostridia	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
DEZH2_k127_10537716_2	720554.Clocl_1386	8.162e-50	180.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,3WGQZ@541000|Ruminococcaceae	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
DEZH2_k127_10537716_3	1392491.JIAE01000001_gene1322	4.399e-40	151.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,3WK6U@541000|Ruminococcaceae	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
DEZH2_k127_10537716_1	1392491.JIAE01000001_gene1438	8.156e-60	222.0	COG2199@1|root,COG2199@2|Bacteria,1V24E@1239|Firmicutes,24FW6@186801|Clostridia,3WNGE@541000|Ruminococcaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
DEZH2_k127_10537716_4	755731.Clo1100_2661	1.065e-07	54.0	COG0205@1|root,COG0205@2|Bacteria,1TRJQ@1239|Firmicutes,247IV@186801|Clostridia,36FK7@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
DEZH2_k127_10537716_0	699246.HMPREF0868_0847	4.814e-143	457.0	COG0205@1|root,COG0205@2|Bacteria,1TRJQ@1239|Firmicutes,247IV@186801|Clostridia,2688K@186813|unclassified Clostridiales	186801|Clostridia	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
DEZH2_k127_1056793_0	1120998.AUFC01000038_gene1249	1.994e-26	127.0	COG0739@1|root,COG4219@1|root,COG0739@2|Bacteria,COG4219@2|Bacteria,1TP3Z@1239|Firmicutes,249NV@186801|Clostridia	186801|Clostridia	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,Peptidase_M56
DEZH2_k127_10570482_0	1410638.JHXJ01000011_gene682	4.25e-109	356.0	COG0126@1|root,COG0149@1|root,COG0126@2|Bacteria,COG0149@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,3WGM9@541000|Ruminococcaceae	186801|Clostridia	G	Phosphoglycerate kinase	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
DEZH2_k127_10570482_2	221027.JO40_01325	3.357e-58	211.0	COG2738@1|root,COG2738@2|Bacteria,2J6KI@203691|Spirochaetes	203691|Spirochaetes	S	zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
DEZH2_k127_10570482_5	526218.Sterm_3575	3.581e-19	93.0	2B4R7@1|root,31XHI@2|Bacteria,37AIA@32066|Fusobacteria	32066|Fusobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10570482_1	1169144.KB910966_gene3447	2.767e-76	286.0	COG4485@1|root,COG4485@2|Bacteria,1TRR1@1239|Firmicutes,4HBW6@91061|Bacilli,1ZQ44@1386|Bacillus	91061|Bacilli	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
DEZH2_k127_10570482_4	1158294.JOMI01000007_gene600	7.254e-39	164.0	COG1807@1|root,COG1807@2|Bacteria,4P1S8@976|Bacteroidetes,2FX9Y@200643|Bacteroidia	976|Bacteroidetes	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_10570482_3	1410638.JHXJ01000004_gene1994	9.223e-52	184.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,3WHP7@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
DEZH2_k127_10613330_0	203119.Cthe_1035	2.831e-180	580.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,3WGTP@541000|Ruminococcaceae	186801|Clostridia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
DEZH2_k127_10613330_1	1089548.KI783301_gene117	2.141e-20	99.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,4HM35@91061|Bacilli,3WEUD@539002|Bacillales incertae sedis	91061|Bacilli	H	5-formyltetrahydrofolate cyclo-ligase family	fthC	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0030272,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
DEZH2_k127_10620854_2	1291050.JAGE01000001_gene1626	1.594e-27	111.0	COG1533@1|root,COG1533@2|Bacteria,1TQA6@1239|Firmicutes,24A2T@186801|Clostridia,3WIAI@541000|Ruminococcaceae	186801|Clostridia	L	Domain of unknown function (DUF1848)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1848
DEZH2_k127_10620854_4	1211813.CAPH01000006_gene1394	9.593e-15	76.0	COG1533@1|root,COG1533@2|Bacteria,4NH5J@976|Bacteroidetes,2G05X@200643|Bacteroidia	976|Bacteroidetes	L	Domain of unknown function (DUF1848)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1848
DEZH2_k127_10620854_3	1408306.JHXX01000001_gene2398	1.185e-15	83.0	COG1680@1|root,COG1680@2|Bacteria,1TRR5@1239|Firmicutes,249KP@186801|Clostridia,4BWBT@830|Butyrivibrio	186801|Clostridia	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase,Gram_pos_anchor
DEZH2_k127_10620854_1	931626.Awo_c01810	1.357e-119	397.0	arCOG12964@1|root,2Z7HP@2|Bacteria,1UZIT@1239|Firmicutes,24G0N@186801|Clostridia,25YS8@186806|Eubacteriaceae	186801|Clostridia	S	Tocopherol cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Tocopherol_cycl
DEZH2_k127_10620854_0	203119.Cthe_1189	4.178e-147	472.0	COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,247KC@186801|Clostridia	186801|Clostridia	S	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_10621338_0	1392491.JIAE01000001_gene372	0.0	1321.0	COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,3WGVS@541000|Ruminococcaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
DEZH2_k127_10640348_1	748727.CLJU_c04010	9.736e-20	101.0	COG2199@1|root,COG2199@2|Bacteria,1URSX@1239|Firmicutes,24XS4@186801|Clostridia,36QP1@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
DEZH2_k127_10640348_0	272562.CA_C2585	5.233e-51	185.0	COG0720@1|root,COG0720@2|Bacteria,1VEAX@1239|Firmicutes,24KY7@186801|Clostridia,36KKE@31979|Clostridiaceae	186801|Clostridia	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
DEZH2_k127_10640348_2	290402.Cbei_3033	2.142e-10	63.0	COG4758@1|root,COG4758@2|Bacteria,1V7WJ@1239|Firmicutes,24A1Z@186801|Clostridia,36F53@31979|Clostridiaceae	186801|Clostridia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
DEZH2_k127_10644274_0	1499689.CCNN01000014_gene3210	1.512e-103	351.0	COG0642@1|root,COG2205@2|Bacteria,1TRC1@1239|Firmicutes,249XJ@186801|Clostridia,36HEU@31979|Clostridiaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
DEZH2_k127_10644274_1	1449343.JQLQ01000002_gene1976	1.088e-52	189.0	arCOG06481@1|root,2ZB4E@2|Bacteria,1V0ND@1239|Firmicutes,4HFG5@91061|Bacilli,27FK3@186828|Carnobacteriaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1122312_3	1304880.JAGB01000002_gene2098	4.418e-20	95.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia	186801|Clostridia	S	ComF family	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
DEZH2_k127_1122312_0	1392491.JIAE01000001_gene1566	2.093e-86	293.0	COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,249SF@186801|Clostridia,3WHD9@541000|Ruminococcaceae	186801|Clostridia	E	serine O-acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
DEZH2_k127_1122312_1	1392491.JIAE01000001_gene1565	4.36e-65	235.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,3WHD2@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
DEZH2_k127_1122312_2	1242864.D187_005434	1.361e-21	106.0	COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,1NQTI@1224|Proteobacteria,43C0D@68525|delta/epsilon subdivisions,2WIYN@28221|Deltaproteobacteria,2YYKX@29|Myxococcales	28221|Deltaproteobacteria	NT	PAS domain	-	-	2.1.1.80,3.1.1.61	ko:K00575,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,PAS_10,PAS_4
DEZH2_k127_1290702_9	1313421.JHBV01000016_gene5483	2.686e-21	100.0	COG1680@1|root,COG1680@2|Bacteria,4NHNN@976|Bacteroidetes,1IVTZ@117747|Sphingobacteriia	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
DEZH2_k127_1290702_1	411473.RUMCAL_01723	3.637e-126	412.0	COG0697@1|root,COG0697@2|Bacteria,1TPST@1239|Firmicutes,248K5@186801|Clostridia,3WHTX@541000|Ruminococcaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DEZH2_k127_1290702_10	1167006.UWK_01254	6.574e-16	85.0	COG1309@1|root,COG1309@2|Bacteria,1MYVR@1224|Proteobacteria,42SV2@68525|delta/epsilon subdivisions,2WPSA@28221|Deltaproteobacteria,2MPEM@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
DEZH2_k127_1290702_11	1123308.KB904538_gene64	4.616e-08	65.0	COG1994@1|root,COG1994@2|Bacteria,1TSHB@1239|Firmicutes,4IR85@91061|Bacilli	91061|Bacilli	S	the current gene model (or a revised gene model) may contain a premature stop	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1290702_5	410358.Mlab_0536	2.57e-58	209.0	arCOG08019@1|root,arCOG08019@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332
DEZH2_k127_1290702_8	398512.JQKC01000001_gene2145	1.553e-25	114.0	2A4HR@1|root,30T4A@2|Bacteria,1V3W0@1239|Firmicutes,24I5I@186801|Clostridia,3WJ3D@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1290702_7	1034807.FBFL15_1254	1.18e-27	120.0	2EGH2@1|root,33A95@2|Bacteria,4NWV7@976|Bacteroidetes,1I5F5@117743|Flavobacteriia,2NXVC@237|Flavobacterium	976|Bacteroidetes	S	Domain of unknown function (DUF4375)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4375
DEZH2_k127_1290702_6	1410670.JHXF01000004_gene1550	2.802e-52	188.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia	186801|Clostridia	FG	PFAM Histidine triad (HIT) protein	-	-	-	-	-	-	-	-	-	-	-	-	HIT
DEZH2_k127_1290702_2	1280680.AUJU01000020_gene2096	3.415e-89	329.0	COG1520@1|root,COG1520@2|Bacteria,1UY1I@1239|Firmicutes,247WP@186801|Clostridia,4BXFS@830|Butyrivibrio	186801|Clostridia	S	MTH538 TIR-like domain (DUF1863)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1863,PQQ_2
DEZH2_k127_1290702_0	877420.ATVW01000010_gene2343	3.721e-134	443.0	COG0618@1|root,COG0618@2|Bacteria,1UKBY@1239|Firmicutes,24EAR@186801|Clostridia,27JPK@186928|unclassified Lachnospiraceae	186801|Clostridia	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
DEZH2_k127_1290702_4	768710.DesyoDRAFT_3295	3.566e-72	254.0	COG0778@1|root,COG0778@2|Bacteria,1V0NJ@1239|Firmicutes,24FM7@186801|Clostridia,261PI@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
DEZH2_k127_1290702_3	1158294.JOMI01000001_gene1612	6.313e-87	291.0	COG2249@1|root,COG2249@2|Bacteria,4NSMD@976|Bacteroidetes,2FUG2@200643|Bacteroidia	976|Bacteroidetes	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
DEZH2_k127_1290702_12	610130.Closa_3499	0.0005948	42.0	COG0622@1|root,COG2908@1|root,COG0622@2|Bacteria,COG2908@2|Bacteria,1V0JZ@1239|Firmicutes,24V95@186801|Clostridia	186801|Clostridia	S	PFAM Metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
DEZH2_k127_130907_6	1408323.JQKK01000009_gene1218	3.621e-17	93.0	COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia,27JPS@186928|unclassified Lachnospiraceae	186801|Clostridia	L	PD-(D/E)XK nuclease superfamily	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
DEZH2_k127_130907_0	1392491.JIAE01000001_gene1770	1.821e-234	741.0	COG1022@1|root,COG1022@2|Bacteria,1TS22@1239|Firmicutes,24AZW@186801|Clostridia,3WHKE@541000|Ruminococcaceae	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
DEZH2_k127_130907_1	1410638.JHXJ01000042_gene2486	1.711e-77	266.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	-	-	2.3.1.51,6.2.1.3	ko:K00655,ko:K01897	ko00061,ko00071,ko00561,ko00564,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00561,map00564,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086,M00089	R01280,R02241,R09381	RC00004,RC00014,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,Acyltransferase
DEZH2_k127_130907_3	1410638.JHXJ01000006_gene2510	1.111e-70	250.0	COG1597@1|root,COG1597@2|Bacteria,1V1DP@1239|Firmicutes,24K52@186801|Clostridia,3WQBX@541000|Ruminococcaceae	186801|Clostridia	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
DEZH2_k127_130907_5	1392491.JIAE01000001_gene1774	1.958e-20	94.0	2EA83@1|root,30CRG@2|Bacteria,1W2RC@1239|Firmicutes	1239|Firmicutes	Q	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
DEZH2_k127_130907_4	1392491.JIAE01000001_gene1775	1.348e-52	190.0	COG1846@1|root,COG1846@2|Bacteria,1V6GY@1239|Firmicutes,24HTB@186801|Clostridia,3WKDN@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR,MarR_2
DEZH2_k127_130907_2	1120746.CCNL01000017_gene2388	1.501e-73	251.0	COG1453@1|root,COG1453@2|Bacteria,2NNZZ@2323|unclassified Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17,Fer4_9
DEZH2_k127_1317902_2	1392491.JIAE01000001_gene404	5.179e-48	177.0	COG3601@1|root,COG3601@2|Bacteria,1V4BW@1239|Firmicutes,24E4V@186801|Clostridia,3WI1Y@541000|Ruminococcaceae	186801|Clostridia	S	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins	ribU	-	-	-	-	-	-	-	-	-	-	-	ECF_trnsprt
DEZH2_k127_1317902_5	666686.B1NLA3E_11615	3.033e-10	70.0	COG4767@1|root,COG4767@2|Bacteria,1VAH6@1239|Firmicutes,4HIHH@91061|Bacilli,1ZHFC@1386|Bacillus	91061|Bacilli	V	COG4767 Glycopeptide antibiotics resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
DEZH2_k127_1317902_4	350688.Clos_2352	5.776e-13	74.0	COG1695@1|root,COG1695@2|Bacteria,1VAKA@1239|Firmicutes,24MVF@186801|Clostridia,36M0F@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator PadR family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
DEZH2_k127_1317902_1	1392491.JIAE01000001_gene392	6.339e-61	225.0	COG0300@1|root,COG0300@2|Bacteria,1V3UX@1239|Firmicutes,25B0Y@186801|Clostridia,3WSAI@541000|Ruminococcaceae	186801|Clostridia	S	Enoyl-(Acyl carrier protein) reductase	sdh	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
DEZH2_k127_1317902_3	699246.HMPREF0868_1451	2.112e-25	119.0	COG0860@1|root,COG0860@2|Bacteria	2|Bacteria	M	N-Acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448,ko:K02172	ko01501,ko01503,map01501,map01503	M00627,M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko03036	-	-	-	Amidase_3,Cu_amine_oxidN1,Glucosaminidase,PG_binding_1,Peptidase_M56,Y_Y_Y
DEZH2_k127_1317902_0	1392491.JIAE01000001_gene393	4.274e-220	688.0	COG0488@1|root,COG0488@2|Bacteria,1TPW0@1239|Firmicutes,248ST@186801|Clostridia,3WGSP@541000|Ruminococcaceae	186801|Clostridia	S	ABC transporter	ykpA	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
DEZH2_k127_1322402_1	1195236.CTER_1584	4.177e-117	393.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,3WH8B@541000|Ruminococcaceae	186801|Clostridia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
DEZH2_k127_1322402_3	1410638.JHXJ01000019_gene477	1.84e-63	238.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,3WHDC@541000|Ruminococcaceae	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
DEZH2_k127_1322402_2	1195236.CTER_1582	1.009e-66	231.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,3WIX7@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
DEZH2_k127_1322402_0	699246.HMPREF0868_0901	4.037e-235	743.0	COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,2686J@186813|unclassified Clostridiales	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
DEZH2_k127_1322402_4	1392491.JIAE01000001_gene2053	8.252e-30	120.0	COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,2484K@186801|Clostridia,3WGQ1@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
DEZH2_k127_1394909_1	1499680.CCFE01000031_gene3710	2.705e-140	468.0	COG0577@1|root,COG1511@1|root,COG4591@1|root,COG0577@2|Bacteria,COG1511@2|Bacteria,COG4591@2|Bacteria,1TPHU@1239|Firmicutes,4HA2C@91061|Bacilli,1ZDI6@1386|Bacillus	91061|Bacilli	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DEZH2_k127_1394909_0	699246.HMPREF0868_1400	2.022e-185	593.0	COG1158@1|root,COG3170@1|root,COG1158@2|Bacteria,COG3170@2|Bacteria,1TPHZ@1239|Firmicutes,247YK@186801|Clostridia,267SY@186813|unclassified Clostridiales	186801|Clostridia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
DEZH2_k127_1394909_2	913865.DOT_0945	4.451e-38	145.0	COG1695@1|root,COG1695@2|Bacteria,1UHRK@1239|Firmicutes,25F64@186801|Clostridia	186801|Clostridia	K	Domain of unknown function (DUF4180)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4180,PadR,Vir_act_alpha_C
DEZH2_k127_1394909_4	1410638.JHXJ01000003_gene1441	9.909e-29	117.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,3WKI1@541000|Ruminococcaceae	186801|Clostridia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
DEZH2_k127_1394909_3	1410638.JHXJ01000003_gene1440	1.245e-30	126.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,25C8E@186801|Clostridia,3WHQ1@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	prmC	-	-	-	-	-	-	-	-	-	-	-	DUF1385,MTS
DEZH2_k127_1411100_3	679192.HMPREF9013_0132	2.497e-16	79.0	COG1511@1|root,COG1511@2|Bacteria,1TPFN@1239|Firmicutes,3VQ9G@526524|Erysipelotrichia	526524|Erysipelotrichia	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
DEZH2_k127_1411100_1	760011.Spico_0250	3.364e-108	356.0	COG1131@1|root,COG1131@2|Bacteria,2J5ZR@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_1411100_2	243275.TDE_0703	1.365e-26	111.0	COG2002@1|root,COG2002@2|Bacteria,2J8TI@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
DEZH2_k127_1411100_0	1121871.AUAT01000006_gene1580	1.346e-146	470.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4HC58@91061|Bacilli,27ECW@186827|Aerococcaceae	91061|Bacilli	S	ABC transporter	yheS_1	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
DEZH2_k127_1415774_1	1410638.JHXJ01000013_gene2333	1.571e-06	55.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,3WH8K@541000|Ruminococcaceae	186801|Clostridia	O	Peptidase U32	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
DEZH2_k127_1415774_0	1392491.JIAE01000001_gene1416	7.283e-130	439.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,3WH8K@541000|Ruminococcaceae	186801|Clostridia	O	Peptidase U32	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
DEZH2_k127_1415774_2	1230342.CTM_16397	3.19e-06	57.0	COG3027@1|root,COG3027@2|Bacteria,1VIXT@1239|Firmicutes,24RYN@186801|Clostridia,36ISE@31979|Clostridiaceae	186801|Clostridia	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
DEZH2_k127_1429100_2	545697.HMPREF0216_00778	1.1e-71	250.0	COG0069@1|root,COG0070@1|root,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,36DW6@31979|Clostridiaceae	186801|Clostridia	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
DEZH2_k127_1429100_1	1504822.CCNO01000014_gene1173	1.851e-238	752.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2NP08@2323|unclassified Bacteria	2|Bacteria	E	Glutamate synthase central domain	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
DEZH2_k127_1429100_0	203119.Cthe_0196	4.611e-286	893.0	COG3968@1|root,COG3968@2|Bacteria,1UHUF@1239|Firmicutes,2481B@186801|Clostridia,3WHCK@541000|Ruminococcaceae	186801|Clostridia	S	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
DEZH2_k127_1429100_4	1284708.HMPREF1634_01880	0.0001873	50.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	-	-	5.2.1.8	ko:K03769,ko:K03770,ko:K03771,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3
DEZH2_k127_1429100_3	720554.Clocl_3179	4.896e-59	211.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,3WGVE@541000|Ruminococcaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_1459743_1	1410638.JHXJ01000013_gene2344	1.924e-73	253.0	COG0461@1|root,COG0461@2|Bacteria,1TS3K@1239|Firmicutes,24D7Z@186801|Clostridia,3WICY@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	-
DEZH2_k127_1459743_0	1392491.JIAE01000001_gene1400	8.33e-119	389.0	COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,248CQ@186801|Clostridia,3WGC5@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
DEZH2_k127_1459743_2	1392491.JIAE01000001_gene1399	7.743e-68	239.0	COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,3WGW1@541000|Ruminococcaceae	186801|Clostridia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
DEZH2_k127_1459743_3	203119.Cthe_0951	2.177e-09	59.0	COG0284@1|root,COG0284@2|Bacteria,1TQ7P@1239|Firmicutes,247SZ@186801|Clostridia,3WH6X@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17585	OMPdecase
DEZH2_k127_1472444_2	1408473.JHXO01000004_gene2	8.183e-35	139.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_2
DEZH2_k127_1472444_3	1319815.HMPREF0202_00718	9.036e-26	115.0	COG1309@1|root,COG1309@2|Bacteria,37AV5@32066|Fusobacteria	32066|Fusobacteria	K	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
DEZH2_k127_1472444_0	994573.T472_0215645	3.379e-134	434.0	COG0715@1|root,COG0715@2|Bacteria,1TT2F@1239|Firmicutes,249M2@186801|Clostridia,36F3S@31979|Clostridiaceae	186801|Clostridia	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2,Phosphonate-bd,VitK2_biosynth
DEZH2_k127_1472444_1	994573.T472_0215640	2.509e-83	284.0	COG0600@1|root,COG0600@2|Bacteria,1V73W@1239|Firmicutes,24A2R@186801|Clostridia,36FJW@31979|Clostridiaceae	186801|Clostridia	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran,BPD_transp_1
DEZH2_k127_1484509_0	1499685.CCFJ01000023_gene2392	1.039e-206	662.0	COG3867@1|root,COG3867@2|Bacteria,1TQDZ@1239|Firmicutes,4HBYA@91061|Bacilli,1ZBZ2@1386|Bacillus	91061|Bacilli	G	arabinogalactan	ganB	-	3.2.1.89	ko:K01224	-	-	-	-	ko00000,ko01000	-	-	-	Big_4,Glyco_hydro_53,Gram_pos_anchor,SLH
DEZH2_k127_1484509_1	642492.Clole_0689	1.144e-110	367.0	COG1609@1|root,COG1609@2|Bacteria,1TPZM@1239|Firmicutes,248WQ@186801|Clostridia	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
DEZH2_k127_1484509_2	869209.Tresu_2197	1.079e-92	314.0	COG2182@1|root,COG2182@2|Bacteria,2J5S3@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding protein	-	-	-	ko:K15770	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	SBP_bac_8
DEZH2_k127_1596629_0	573061.Clocel_1499	6.399e-68	232.0	COG2407@1|root,COG2407@2|Bacteria,1TQ5Q@1239|Firmicutes,248V0@186801|Clostridia,36E76@31979|Clostridiaceae	186801|Clostridia	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	fucI	-	5.3.1.25,5.3.1.3	ko:K01818	ko00051,ko01120,map00051,map01120	-	R03163	RC00434	ko00000,ko00001,ko01000	-	-	-	Fucose_iso_C,Fucose_iso_N1,Fucose_iso_N2
DEZH2_k127_1596629_1	1541960.KQ78_01718	2.632e-40	157.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	grdR	-	-	-	-	-	-	-	-	-	-	-	TetR_N
DEZH2_k127_1596629_2	666686.B1NLA3E_11880	3.714e-38	148.0	COG0716@1|root,COG0716@2|Bacteria,1VFBM@1239|Firmicutes,4HYKX@91061|Bacilli	91061|Bacilli	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1596629_3	1541960.KQ78_01716	5.054e-21	97.0	COG3976@1|root,COG3976@2|Bacteria	2|Bacteria	S	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
DEZH2_k127_1596629_4	720554.Clocl_0365	9.632e-19	98.0	2DKID@1|root,309JM@2|Bacteria,1U58H@1239|Firmicutes,24XUF@186801|Clostridia,3WN7F@541000|Ruminococcaceae	186801|Clostridia	S	YcxB-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YcxB
DEZH2_k127_1596629_5	509191.AEDB02000033_gene5128	0.0001206	52.0	2DKID@1|root,309JM@2|Bacteria,1U58H@1239|Firmicutes,24XUF@186801|Clostridia,3WN7F@541000|Ruminococcaceae	186801|Clostridia	S	YcxB-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YcxB
DEZH2_k127_161961_2	1131462.DCF50_p2524	5.047e-45	173.0	COG1277@1|root,COG1277@2|Bacteria,1TRD6@1239|Firmicutes,24DIY@186801|Clostridia,261MV@186807|Peptococcaceae	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
DEZH2_k127_161961_0	1145276.T479_07870	4.541e-125	407.0	COG1131@1|root,COG1131@2|Bacteria,1TQHS@1239|Firmicutes,4HC34@91061|Bacilli,3IZKI@400634|Lysinibacillus	91061|Bacilli	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DEZH2_k127_161961_3	931626.Awo_c10220	1.684e-33	135.0	COG1633@1|root,COG1633@2|Bacteria,1V7QZ@1239|Firmicutes,24JY1@186801|Clostridia	186801|Clostridia	S	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DEZH2_k127_161961_1	663278.Ethha_0424	1.68e-76	264.0	COG1028@1|root,COG1028@2|Bacteria,1TZY6@1239|Firmicutes,248QZ@186801|Clostridia,3WIP8@541000|Ruminococcaceae	186801|Clostridia	IQ	Oxidoreductase, short chain dehydrogenase reductase family protein	fabG5	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
DEZH2_k127_1653843_3	622312.ROSEINA2194_02596	2.21e-17	95.0	COG0030@1|root,COG0030@2|Bacteria,1V28P@1239|Firmicutes	1239|Firmicutes	J	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_1653843_2	44251.PDUR_24895	1.136e-73	258.0	COG2242@1|root,COG2242@2|Bacteria	2|Bacteria	H	protein methyltransferase activity	-	-	2.1.1.132	ko:K00595	ko00860,ko01100,map00860,map01100	-	R05149	RC00003,RC01279	ko00000,ko00001,ko01000	-	-	-	DOT1,Methyltransf_11,Methyltransf_12,Methyltransf_21,Methyltransf_23,Methyltransf_25
DEZH2_k127_1653843_0	1410632.JHWW01000002_gene2151	2.113e-142	464.0	COG1134@1|root,COG1134@2|Bacteria,1TQKK@1239|Firmicutes,24A5V@186801|Clostridia,27J3V@186928|unclassified Lachnospiraceae	186801|Clostridia	GM	ATPases associated with a variety of cellular activities	-	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
DEZH2_k127_1653843_1	476272.RUMHYD_02538	3.183e-77	267.0	COG1682@1|root,COG1682@2|Bacteria,1TQZF@1239|Firmicutes,248R0@186801|Clostridia,3XZE2@572511|Blautia	186801|Clostridia	GM	ABC-2 type transporter	-	-	-	ko:K09692	ko02010,map02010	M00251	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.104	-	-	ABC2_membrane
DEZH2_k127_1671673_1	1392491.JIAE01000001_gene1261	3.111e-19	88.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,3WIF0@541000|Ruminococcaceae	186801|Clostridia	S	Flavin reductase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
DEZH2_k127_1671673_2	1392491.JIAE01000001_gene1261	3.432e-19	89.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,3WIF0@541000|Ruminococcaceae	186801|Clostridia	S	Flavin reductase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
DEZH2_k127_1671673_0	699246.HMPREF0868_0847	2.312e-177	561.0	COG0205@1|root,COG0205@2|Bacteria,1TRJQ@1239|Firmicutes,247IV@186801|Clostridia,2688K@186813|unclassified Clostridiales	186801|Clostridia	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
DEZH2_k127_1678057_0	1235790.C805_00437	3.399e-140	466.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
DEZH2_k127_1678057_4	272562.CA_C2327	0.0002943	51.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1TSTE@1239|Firmicutes,249WH@186801|Clostridia,36E4U@31979|Clostridiaceae	186801|Clostridia	M	glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
DEZH2_k127_1678057_2	658655.HMPREF0988_01771	1.141e-75	278.0	COG4713@1|root,COG4713@2|Bacteria,1UY68@1239|Firmicutes,24A5N@186801|Clostridia,27NKI@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Predicted membrane protein (DUF2142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142
DEZH2_k127_1678057_1	537013.CLOSTMETH_00306	5.888e-94	334.0	COG4713@1|root,COG4713@2|Bacteria,1V77Y@1239|Firmicutes,24C6B@186801|Clostridia,3WKKN@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142
DEZH2_k127_1678057_3	491205.JARQ01000003_gene1970	1.078e-19	91.0	COG0438@1|root,COG0438@2|Bacteria,4NGU7@976|Bacteroidetes,1I01U@117743|Flavobacteriia,3ZSUQ@59732|Chryseobacterium	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DEZH2_k127_1695295_0	1449343.JQLQ01000002_gene979	2.983e-89	302.0	COG1876@1|root,COG1876@2|Bacteria,1TQQ3@1239|Firmicutes,4HE78@91061|Bacilli,27H0G@186828|Carnobacteriaceae	91061|Bacilli	M	Clostridial hydrophobic, with a conserved W residue, domain.	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,ChW
DEZH2_k127_1695295_3	1408324.JNJK01000015_gene2451	1.751e-61	224.0	COG1442@1|root,COG1442@2|Bacteria,1VD1B@1239|Firmicutes,24N4V@186801|Clostridia,27JDJ@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_8
DEZH2_k127_1695295_2	33035.JPJF01000067_gene3544	8.263e-69	249.0	COG2244@1|root,COG2244@2|Bacteria,1UYWC@1239|Firmicutes,25CW4@186801|Clostridia	186801|Clostridia	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
DEZH2_k127_1695295_5	203119.Cthe_2357	2.091e-13	82.0	COG4640@1|root,COG4640@2|Bacteria,1V6D3@1239|Firmicutes,25ESD@186801|Clostridia,3WSJ6@541000|Ruminococcaceae	186801|Clostridia	S	response to antibiotic	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
DEZH2_k127_1695295_4	1280668.ATVT01000010_gene2121	3.594e-57	205.0	COG0575@1|root,COG0575@2|Bacteria,1V6V6@1239|Firmicutes,24KZJ@186801|Clostridia	186801|Clostridia	I	CDP-archaeol synthase	-	-	-	-	-	-	-	-	-	-	-	-	CarS-like
DEZH2_k127_1777855_2	86416.Clopa_2984	1.965e-05	48.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia,36EA6@31979|Clostridiaceae	186801|Clostridia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
DEZH2_k127_1777855_0	1410638.JHXJ01000033_gene28	1.314e-114	373.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia,3WH0Y@541000|Ruminococcaceae	186801|Clostridia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
DEZH2_k127_1777855_1	1392491.JIAE01000001_gene2437	1.798e-31	135.0	COG3935@1|root,COG3935@2|Bacteria,1VJUD@1239|Firmicutes,25Q73@186801|Clostridia,3WHU3@541000|Ruminococcaceae	186801|Clostridia	L	Replication initiation and membrane attachment	-	-	-	-	-	-	-	-	-	-	-	-	DnaB_2
DEZH2_k127_1794791_0	1410638.JHXJ01000021_gene2369	1.926e-126	418.0	COG4260@1|root,COG4260@2|Bacteria,1TRYU@1239|Firmicutes,24901@186801|Clostridia,3WHZY@541000|Ruminococcaceae	186801|Clostridia	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,SHOCT
DEZH2_k127_1794791_3	585394.RHOM_02615	2.797e-36	148.0	2EN4B@1|root,33FSE@2|Bacteria,1VPF9@1239|Firmicutes,24SXK@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Tim44,zinc_ribbon_2
DEZH2_k127_1794791_1	1392491.JIAE01000001_gene2357	6.933e-60	216.0	COG1192@1|root,COG1192@2|Bacteria,1UI32@1239|Firmicutes,25EC1@186801|Clostridia,3WREH@541000|Ruminococcaceae	186801|Clostridia	D	Involved in chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
DEZH2_k127_1794791_2	1291050.JAGE01000001_gene296	1.753e-51	187.0	COG3635@1|root,COG3635@2|Bacteria,1TQ5S@1239|Firmicutes,248U6@186801|Clostridia,3WH2J@541000|Ruminococcaceae	186801|Clostridia	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
DEZH2_k127_1810138_11	1502770.JQMG01000001_gene754	0.0006879	45.0	COG4968@1|root,COG4968@2|Bacteria,1MZZW@1224|Proteobacteria,2VU8H@28216|Betaproteobacteria,2KN6M@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	Type IV minor pilin ComP, DNA uptake sequence receptor	-	-	-	ko:K02655	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	ComP_DUS,N_methyl
DEZH2_k127_1810138_2	1410638.JHXJ01000039_gene980	1.146e-144	467.0	COG4972@1|root,COG4972@2|Bacteria,1V3TN@1239|Firmicutes,24ASH@186801|Clostridia,3WHWV@541000|Ruminococcaceae	186801|Clostridia	NU	Type IV pilus assembly protein PilM;	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2,PilN
DEZH2_k127_1810138_1	1392491.JIAE01000001_gene603	6.725e-149	481.0	COG1459@1|root,COG1459@2|Bacteria,1TQRZ@1239|Firmicutes,249FV@186801|Clostridia,3WI9J@541000|Ruminococcaceae	186801|Clostridia	NU	Type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
DEZH2_k127_1810138_6	1131462.DCF50_p2046	8.245e-52	187.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia,26058@186807|Peptococcaceae	186801|Clostridia	NU	secretion system protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
DEZH2_k127_1810138_3	1392491.JIAE01000001_gene602	8.575e-109	354.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia,3WGU2@541000|Ruminococcaceae	186801|Clostridia	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
DEZH2_k127_1810138_0	1392491.JIAE01000001_gene601	1.603e-265	826.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,3WGDE@541000|Ruminococcaceae	186801|Clostridia	NU	type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
DEZH2_k127_1810138_7	1392491.JIAE01000001_gene600	1.25e-35	147.0	COG1989@1|root,COG1989@2|Bacteria,1TQY4@1239|Firmicutes,24HC0@186801|Clostridia,3WGTI@541000|Ruminococcaceae	186801|Clostridia	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
DEZH2_k127_1810138_4	1392491.JIAE01000001_gene599	1.123e-100	335.0	COG0217@1|root,COG0217@2|Bacteria,1TPP5@1239|Firmicutes,247NK@186801|Clostridia,3WHDN@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulatory protein	yebC	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
DEZH2_k127_1810138_5	1392491.JIAE01000001_gene598	1.593e-56	203.0	COG0563@1|root,COG1302@1|root,COG0563@2|Bacteria,COG1302@2|Bacteria,1V1TU@1239|Firmicutes,24E60@186801|Clostridia,3WJ2N@541000|Ruminococcaceae	186801|Clostridia	F	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Asp23,IPT
DEZH2_k127_1815462_1	398512.JQKC01000022_gene3600	2.961e-75	261.0	COG0300@1|root,COG0300@2|Bacteria,1TRP8@1239|Firmicutes,24DNY@186801|Clostridia,3WJMU@541000|Ruminococcaceae	186801|Clostridia	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
DEZH2_k127_1815462_0	398512.JQKC01000022_gene3601	2.965e-93	317.0	COG1533@1|root,COG1533@2|Bacteria,1TPA3@1239|Firmicutes,249NM@186801|Clostridia,3WP0V@541000|Ruminococcaceae	186801|Clostridia	L	Spore photoproduct lyase	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	-
DEZH2_k127_1824857_2	1121115.AXVN01000006_gene2155	4.234e-128	422.0	COG0777@1|root,COG0825@1|root,COG0777@2|Bacteria,COG0825@2|Bacteria,1TP4U@1239|Firmicutes,248QK@186801|Clostridia,3XYX8@572511|Blautia	186801|Clostridia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS20740	ACCA,Carboxyl_trans
DEZH2_k127_1824857_0	537013.CLOSTMETH_00739	9.138e-187	595.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,25E48@186801|Clostridia,3WHD3@541000|Ruminococcaceae	186801|Clostridia	I	acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
DEZH2_k127_1824857_7	537013.CLOSTMETH_00738	4.137e-51	186.0	COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,24JAW@186801|Clostridia,3WJ8D@541000|Ruminococcaceae	186801|Clostridia	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
DEZH2_k127_1824857_9	159450.NH14_25565	3.399e-24	108.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2VR5S@28216|Betaproteobacteria,1K707@119060|Burkholderiaceae	28216|Betaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
DEZH2_k127_1824857_1	537013.CLOSTMETH_00736	1.166e-136	447.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,3WGGB@541000|Ruminococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
DEZH2_k127_1824857_5	1280689.AUJC01000004_gene303	1.804e-74	258.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,36EGR@31979|Clostridiaceae	186801|Clostridia	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
DEZH2_k127_1824857_3	537013.CLOSTMETH_00734	5.327e-128	415.0	COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,24831@186801|Clostridia,3WGKK@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	fabK	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iHN637.CLJU_RS20775	NMO
DEZH2_k127_1824857_4	1235835.C814_03075	1.195e-93	317.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,3WHBA@541000|Ruminococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
DEZH2_k127_1824857_6	742725.HMPREF9450_01186	7.231e-56	206.0	COG0331@1|root,COG0331@2|Bacteria,4NE1D@976|Bacteroidetes,2FM9P@200643|Bacteroidia,22U7E@171550|Rikenellaceae	976|Bacteroidetes	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
DEZH2_k127_1824857_8	1294265.JCM21738_881	2.142e-50	200.0	COG5617@1|root,COG5617@2|Bacteria,1V776@1239|Firmicutes,4HYRM@91061|Bacilli	91061|Bacilli	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
DEZH2_k127_1892610_2	1392491.JIAE01000001_gene327	1.796e-114	372.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,3WGEG@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DEZH2_k127_1892610_3	509191.AEDB02000020_gene3364	1.191e-77	261.0	COG0049@1|root,COG0049@2|Bacteria,1V1GG@1239|Firmicutes,24FQN@186801|Clostridia,3WGPA@541000|Ruminococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
DEZH2_k127_1892610_4	1392491.JIAE01000001_gene325	1.372e-71	243.0	COG0048@1|root,COG0048@2|Bacteria,1V1FJ@1239|Firmicutes,24FQT@186801|Clostridia,3WIHG@541000|Ruminococcaceae	186801|Clostridia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
DEZH2_k127_1892610_0	1131462.DCF50_p933	3.801e-285	889.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,2610M@186807|Peptococcaceae	186801|Clostridia	C	iron hydrogenase, small subunit	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_6,Fer4_9,NADH-G_4Fe-4S_3
DEZH2_k127_1892610_1	1131462.DCF50_p934	1.312e-191	606.0	COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,260R6@186807|Peptococcaceae	186801|Clostridia	C	NADH dehydrogenase	nuoF2	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
DEZH2_k127_1908064_1	1392491.JIAE01000001_gene2471	8.147e-141	453.0	COG0202@1|root,COG0202@2|Bacteria,1TPR8@1239|Firmicutes,248DS@186801|Clostridia,3WGUM@541000|Ruminococcaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
DEZH2_k127_1908064_4	1392491.JIAE01000001_gene2470	1.05e-74	254.0	COG0203@1|root,COG0203@2|Bacteria,1V6JQ@1239|Firmicutes,24J9T@186801|Clostridia,3WIPC@541000|Ruminococcaceae	186801|Clostridia	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
DEZH2_k127_1908064_0	1410638.JHXJ01000004_gene2093	1.882e-168	549.0	COG1123@1|root,COG4172@2|Bacteria,1VRD0@1239|Firmicutes,25ECM@186801|Clostridia,3WMZJ@541000|Ruminococcaceae	186801|Clostridia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,DUF3744
DEZH2_k127_1908064_2	1410638.JHXJ01000004_gene2094	2.504e-84	287.0	COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,248AB@186801|Clostridia,3WGYM@541000|Ruminococcaceae	186801|Clostridia	P	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfT	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
DEZH2_k127_1908064_3	1392491.JIAE01000001_gene2467	3.666e-81	275.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,3WHCD@541000|Ruminococcaceae	186801|Clostridia	GK	ROK family	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
DEZH2_k127_1911810_2	1410638.JHXJ01000002_gene1372	2.58e-35	138.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,3WHAC@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rluF	-	5.4.99.21,5.4.99.22	ko:K06178,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
DEZH2_k127_1911810_0	1392491.JIAE01000001_gene1545	3.724e-172	558.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3WGR7@541000|Ruminococcaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07651	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS
DEZH2_k127_1911810_1	1392491.JIAE01000001_gene1544	3.175e-113	368.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,3WGB8@541000|Ruminococcaceae	186801|Clostridia	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_1911810_3	425400.LS65_08645	1.911e-23	102.0	COG4866@1|root,COG4866@2|Bacteria,1RIUZ@1224|Proteobacteria,42P4H@68525|delta/epsilon subdivisions,2YM84@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
DEZH2_k127_1939535_2	658086.HMPREF0994_03291	1.303e-94	323.0	COG0524@1|root,COG0524@2|Bacteria,1TT7Y@1239|Firmicutes,249GN@186801|Clostridia,27JFP@186928|unclassified Lachnospiraceae	186801|Clostridia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
DEZH2_k127_1939535_0	1392491.JIAE01000001_gene680	1.695e-129	426.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,3WIS6@541000|Ruminococcaceae	186801|Clostridia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
DEZH2_k127_1939535_1	1392491.JIAE01000001_gene679	1.157e-115	376.0	COG0745@1|root,COG0745@2|Bacteria,1V3FX@1239|Firmicutes,24GC2@186801|Clostridia	186801|Clostridia	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_1939535_3	658086.HMPREF0994_07089	2.124e-09	68.0	COG5002@1|root,COG5002@2|Bacteria,1UZW7@1239|Firmicutes,24A42@186801|Clostridia,27R9P@186928|unclassified Lachnospiraceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
DEZH2_k127_1944449_1	1392491.JIAE01000001_gene1062	3.002e-180	578.0	COG0248@1|root,COG0248@2|Bacteria,1TS3I@1239|Firmicutes,248EW@186801|Clostridia,3WI8N@541000|Ruminococcaceae	186801|Clostridia	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
DEZH2_k127_1944449_3	1195236.CTER_0882	1.516e-37	146.0	COG1607@1|root,COG1607@2|Bacteria,1V3S2@1239|Firmicutes,24JIT@186801|Clostridia,3WJ94@541000|Ruminococcaceae	186801|Clostridia	I	thioesterase	yciA	-	-	-	-	-	-	-	-	-	-	-	4HBT
DEZH2_k127_1944449_2	1449126.JQKL01000037_gene2047	2.502e-160	522.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,26ANK@186813|unclassified Clostridiales	186801|Clostridia	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
DEZH2_k127_1944449_0	1105031.HMPREF1141_3489	1.571e-212	673.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,36DS1@31979|Clostridiaceae	186801|Clostridia	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
DEZH2_k127_1944449_4	796942.HMPREF9623_01416	1.748e-16	80.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia	186801|Clostridia	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DEZH2_k127_196341_4	476272.RUMHYD_00626	6.538e-16	79.0	2DMSV@1|root,32TFU@2|Bacteria,1VC0G@1239|Firmicutes,24Q3V@186801|Clostridia	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
DEZH2_k127_196341_1	666686.B1NLA3E_08755	3.886e-96	321.0	COG0500@1|root,COG2226@2|Bacteria,1U5XV@1239|Firmicutes,4HBHC@91061|Bacilli	91061|Bacilli	Q	catalyzes the formation of a number of methylated intermediates from arsenite and SAM producing trimethylarsine	arsM	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
DEZH2_k127_196341_3	1121289.JHVL01000019_gene641	6.275e-28	117.0	COG0640@1|root,COG0640@2|Bacteria,1V9KK@1239|Firmicutes,24NXW@186801|Clostridia,36JM8@31979|Clostridiaceae	186801|Clostridia	K	regulatory protein, arsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
DEZH2_k127_196341_2	1131462.DCF50_p199	5.848e-40	151.0	2DMHQ@1|root,32RMG@2|Bacteria,1VB95@1239|Firmicutes,24K45@186801|Clostridia,26204@186807|Peptococcaceae	186801|Clostridia	S	Arsenical resistance operon trans-acting repressor ArsD	arsD	-	-	-	-	-	-	-	-	-	-	-	ArsD
DEZH2_k127_196341_0	768710.DesyoDRAFT_1542	2.077e-295	914.0	COG0003@1|root,COG0003@2|Bacteria,1TQZP@1239|Firmicutes,249JN@186801|Clostridia,260XR@186807|Peptococcaceae	186801|Clostridia	D	TIGRFAM arsenite-activated ATPase (arsA)	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
DEZH2_k127_196341_5	1121289.JHVL01000019_gene637	6.703e-15	78.0	2DRB6@1|root,33B2B@2|Bacteria,1VQHT@1239|Firmicutes,251N5@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2051078_2	1111454.HMPREF1250_1133	0.0002643	43.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,4H3A7@909932|Negativicutes	909932|Negativicutes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
DEZH2_k127_2051078_1	1392491.JIAE01000001_gene631	2.817e-40	151.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,3WJ7F@541000|Ruminococcaceae	186801|Clostridia	FG	histidine triad	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
DEZH2_k127_2051078_0	203119.Cthe_0400	1.745e-63	230.0	COG1594@1|root,COG1594@2|Bacteria,1UHVH@1239|Firmicutes,25E4D@186801|Clostridia,3WSIA@541000|Ruminococcaceae	186801|Clostridia	K	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2097974_7	1121334.KB911066_gene863	1.865e-25	107.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
DEZH2_k127_2097974_6	509191.AEDB02000022_gene3011	6.609e-57	207.0	arCOG03165@1|root,30AIC@2|Bacteria,1V7NB@1239|Firmicutes,24M5X@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2097974_11	1298920.KI911353_gene1400	3.093e-07	52.0	COG2378@1|root,COG2378@2|Bacteria,1TT23@1239|Firmicutes,248A8@186801|Clostridia,22482@1506553|Lachnoclostridium	186801|Clostridia	K	DeoR-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
DEZH2_k127_2097974_3	1131462.DCF50_p2455	3.149e-87	294.0	COG1335@1|root,COG1335@2|Bacteria,1TQTE@1239|Firmicutes,24BQ4@186801|Clostridia,264CC@186807|Peptococcaceae	186801|Clostridia	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
DEZH2_k127_2097974_1	439235.Dalk_2032	1.639e-95	325.0	COG2267@1|root,COG2267@2|Bacteria,1QYAK@1224|Proteobacteria,43ECK@68525|delta/epsilon subdivisions,2WVYY@28221|Deltaproteobacteria,2MPDV@213118|Desulfobacterales	1224|Proteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
DEZH2_k127_2097974_9	1499967.BAYZ01000022_gene250	2.34e-24	109.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
DEZH2_k127_2097974_8	1034347.CAHJ01000048_gene247	5.632e-25	105.0	29XTT@1|root,30JJV@2|Bacteria,1UVYW@1239|Firmicutes,4I6MC@91061|Bacilli,1ZPAT@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2097974_5	573061.Clocel_3254	1.118e-71	243.0	2DBS2@1|root,2ZAP4@2|Bacteria,1V6HV@1239|Firmicutes,24AKN@186801|Clostridia,36GAW@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2097974_0	1392493.JIAB01000001_gene957	1.295e-136	441.0	COG2755@1|root,COG2755@2|Bacteria,1V0XX@1239|Firmicutes,24DNA@186801|Clostridia,27Q1I@186928|unclassified Lachnospiraceae	186801|Clostridia	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
DEZH2_k127_2097974_2	1410630.JNKP01000004_gene377	1.303e-87	293.0	COG0454@1|root,COG0703@1|root,COG0456@2|Bacteria,COG0703@2|Bacteria,1V3K1@1239|Firmicutes,24J0Z@186801|Clostridia,27N4E@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
DEZH2_k127_2097974_4	1211817.CCAT010000009_gene887	5.708e-77	264.0	COG1011@1|root,COG1011@2|Bacteria,1V208@1239|Firmicutes,24E09@186801|Clostridia,36W3U@31979|Clostridiaceae	186801|Clostridia	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
DEZH2_k127_2097974_10	883114.HMPREF9709_00635	1.759e-20	103.0	2ECZX@1|root,336WX@2|Bacteria,1VISD@1239|Firmicutes,24QT1@186801|Clostridia	186801|Clostridia	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
DEZH2_k127_2118783_0	1392491.JIAE01000001_gene2537	3.8e-141	454.0	COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,3WGGQ@541000|Ruminococcaceae	186801|Clostridia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
DEZH2_k127_2118783_1	1392491.JIAE01000001_gene2538	6.661e-128	425.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia,3WGHG@541000|Ruminococcaceae	186801|Clostridia	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
DEZH2_k127_2118783_2	1392491.JIAE01000001_gene2539	8.726e-38	144.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,3WHR4@541000|Ruminococcaceae	186801|Clostridia	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
DEZH2_k127_2121335_1	1286171.EAL2_808p02420	8.75e-74	252.0	COG0348@1|root,COG0348@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
DEZH2_k127_2121335_0	1321778.HMPREF1982_02772	2.636e-145	466.0	COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TPI9@1239|Firmicutes,2496K@186801|Clostridia,267YX@186813|unclassified Clostridiales	186801|Clostridia	K	K13530 AraC family transcriptional regulator, regulatory protein of adaptative response methylphosphotriester-DNA alkyltransferase methyltransferase	-	-	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	Cass2,GyrI-like,HTH_18,HTH_AraC
DEZH2_k127_2121335_2	428125.CLOLEP_01604	4.105e-22	101.0	COG1380@1|root,COG1380@2|Bacteria,1VEN4@1239|Firmicutes,24MMB@186801|Clostridia,3WK3K@541000|Ruminococcaceae	186801|Clostridia	S	effector of murein hydrolase LrgA	lrgA	-	-	ko:K06518	-	-	-	-	ko00000,ko02000	1.E.14.2	-	-	LrgA
DEZH2_k127_2122201_0	1232446.BAIE02000010_gene1950	8.775e-213	677.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,26840@186813|unclassified Clostridiales	186801|Clostridia	E	B12 binding domain	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
DEZH2_k127_2134190_1	1163671.JAGI01000002_gene2567	5.247e-49	180.0	COG0596@1|root,COG0596@2|Bacteria,1V0M4@1239|Firmicutes,24AEI@186801|Clostridia,36G7H@31979|Clostridiaceae	186801|Clostridia	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
DEZH2_k127_2134190_2	994573.T472_0212765	2.116e-40	156.0	COG2452@1|root,COG2452@2|Bacteria,1VBG0@1239|Firmicutes,25H1U@186801|Clostridia,36V7B@31979|Clostridiaceae	186801|Clostridia	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
DEZH2_k127_2134190_0	411465.PEPMIC_01419	4.188e-62	218.0	COG1670@1|root,COG1670@2|Bacteria,1V40U@1239|Firmicutes,24JVI@186801|Clostridia,22IN0@1570339|Peptoniphilaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
DEZH2_k127_2134190_3	1410638.JHXJ01000027_gene1180	2.602e-28	119.0	COG1408@1|root,COG1408@2|Bacteria,1UU17@1239|Firmicutes,248PS@186801|Clostridia,3WGVG@541000|Ruminococcaceae	186801|Clostridia	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
DEZH2_k127_2135047_1	1121334.KB911067_gene98	1.685e-79	279.0	COG1875@1|root,COG1875@2|Bacteria,1UHTD@1239|Firmicutes,25ED1@186801|Clostridia,3WGNM@541000|Ruminococcaceae	186801|Clostridia	T	Large family of predicted nucleotide-binding domains	-	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
DEZH2_k127_2135047_0	1195236.CTER_3753	4.47e-124	407.0	COG0006@1|root,COG0006@2|Bacteria,1TSXE@1239|Firmicutes,248AF@186801|Clostridia,3WN3H@541000|Ruminococcaceae	186801|Clostridia	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
DEZH2_k127_2138761_0	1304880.JAGB01000003_gene1291	9.13e-121	391.0	COG1274@1|root,COG1274@2|Bacteria,1TQED@1239|Firmicutes,249NP@186801|Clostridia	186801|Clostridia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
DEZH2_k127_2138761_1	720554.Clocl_3558	1.723e-120	392.0	COG0489@1|root,COG0489@2|Bacteria,1TQ34@1239|Firmicutes,24817@186801|Clostridia,3WGBQ@541000|Ruminococcaceae	186801|Clostridia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	-	-	-	-	-	-	-	-	-	ParA
DEZH2_k127_2138761_2	1449126.JQKL01000008_gene255	1.946e-101	352.0	COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,26AR3@186813|unclassified Clostridiales	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5,PAS,PAS_4,PAS_8,PAS_9
DEZH2_k127_2138761_5	203119.Cthe_2304	2.907e-43	164.0	COG0685@1|root,COG0685@2|Bacteria,1UZX0@1239|Firmicutes,24B8V@186801|Clostridia	186801|Clostridia	E	Methylenetetrahydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR
DEZH2_k127_2138761_6	720554.Clocl_3002	1.095e-34	136.0	COG0685@1|root,COG0685@2|Bacteria,1UZX0@1239|Firmicutes,24B8V@186801|Clostridia,3WNG6@541000|Ruminococcaceae	186801|Clostridia	C	Methylenetetrahydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR
DEZH2_k127_2138761_3	1392491.JIAE01000001_gene490	8.47e-91	306.0	COG3481@1|root,COG3481@2|Bacteria,1TQEK@1239|Firmicutes,24Q9A@186801|Clostridia	186801|Clostridia	S	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2138761_8	1392491.JIAE01000001_gene492	3.536e-23	100.0	2EBDP@1|root,335EB@2|Bacteria,1VGYB@1239|Firmicutes,2584G@186801|Clostridia,3WKSN@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2138761_4	1499689.CCNN01000015_gene3418	1.206e-77	269.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,36E9N@31979|Clostridiaceae	186801|Clostridia	S	MazG family	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
DEZH2_k127_2138761_9	679200.HMPREF9333_00474	8.948e-07	51.0	COG1188@1|root,COG1188@2|Bacteria,1VEI5@1239|Firmicutes,24QNF@186801|Clostridia	186801|Clostridia	J	S4 domain protein	hslR	-	-	-	-	-	-	-	-	-	-	-	S4
DEZH2_k127_2149569_3	1403946.Q615_SPAC00138G0008	0.0003133	43.0	COG1188@1|root,COG1188@2|Bacteria,1VEI5@1239|Firmicutes,4HKJJ@91061|Bacilli,42DPS@671232|Streptococcus anginosus group	91061|Bacilli	J	S4 domain	yabO	-	-	-	-	-	-	-	-	-	-	-	S4
DEZH2_k127_2149569_2	697281.Mahau_0808	7.233e-05	49.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	divIC	-	-	ko:K05589,ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
DEZH2_k127_2149569_0	394503.Ccel_0244	5.547e-74	254.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,36EFC@31979|Clostridiaceae	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
DEZH2_k127_2149569_1	1034345.CAEM01000023_gene901	3.885e-29	119.0	COG0718@1|root,COG0718@2|Bacteria,2IRC4@201174|Actinobacteria,4CWBC@84998|Coriobacteriia	84998|Coriobacteriia	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
DEZH2_k127_2155856_0	1340434.AXVA01000008_gene3795	2.371e-48	182.0	COG0488@1|root,COG0488@2|Bacteria,1TQNA@1239|Firmicutes,4H9VW@91061|Bacilli,1ZBZP@1386|Bacillus	91061|Bacilli	S	ABC transporter	expZ	-	-	ko:K18231	ko02010,map02010	-	-	-	br01600,ko00000,ko00001,ko01504,ko02000	3.A.1.121.1,3.A.1.121.3	-	-	ABC_tran,ABC_tran_Xtn
DEZH2_k127_2155856_3	1410616.JHXE01000015_gene1757	2.254e-12	78.0	COG4461@1|root,COG4461@2|Bacteria,1VGRM@1239|Firmicutes,25HEJ@186801|Clostridia,3NHMM@46205|Pseudobutyrivibrio	186801|Clostridia	S	Domain of unknown function (DUF4163)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3298,DUF4163
DEZH2_k127_2155856_1	877411.JMMA01000002_gene1911	1.761e-33	152.0	COG4964@1|root,COG4964@2|Bacteria	2|Bacteria	U	Pilus formation protein N terminal region	-	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N,ubiquitin
DEZH2_k127_2155856_2	509191.AEDB02000002_gene1130	3.976e-22	114.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind,Flg_new,Glug,WxL
DEZH2_k127_2156862_0	1280390.CBQR020000158_gene4221	0.0	1125.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,4HDVR@91061|Bacilli,275SH@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl transferase	-	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	Glyco_hydro_36,Glyco_transf_36
DEZH2_k127_2156862_1	588581.Cpap_1812	7.44e-82	284.0	2DUU6@1|root,33S9S@2|Bacteria,1VRCX@1239|Firmicutes,24EBM@186801|Clostridia,3WNVB@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2211922_3	97138.C820_00430	9.971e-31	130.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia,36DZZ@31979|Clostridiaceae	186801|Clostridia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
DEZH2_k127_2211922_1	1392491.JIAE01000001_gene2565	1.226e-52	201.0	COG0577@1|root,COG0577@2|Bacteria,1VFDF@1239|Firmicutes,24TPI@186801|Clostridia,3WS0E@541000|Ruminococcaceae	186801|Clostridia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	MacB_PCD
DEZH2_k127_2211922_0	1410638.JHXJ01000008_gene328	5.589e-70	260.0	COG0845@1|root,COG0845@2|Bacteria,1UZZV@1239|Firmicutes,24AQV@186801|Clostridia,3WKZH@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
DEZH2_k127_2211922_2	1392491.JIAE01000001_gene2567	4.352e-31	122.0	COG0395@1|root,COG0395@2|Bacteria,1TS82@1239|Firmicutes,2488S@186801|Clostridia,3WHSW@541000|Ruminococcaceae	186801|Clostridia	G	ABC-type sugar transport system, permease component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
DEZH2_k127_2229077_1	699246.HMPREF0868_1309	3.56e-129	428.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,2486F@186801|Clostridia,268N5@186813|unclassified Clostridiales	186801|Clostridia	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03697	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small
DEZH2_k127_2229077_0	1392491.JIAE01000001_gene1166	0.0	1339.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,3WN42@541000|Ruminococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
DEZH2_k127_2255408_0	1392491.JIAE01000001_gene1514	4.778e-193	616.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,3WGDZ@541000|Ruminococcaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
DEZH2_k127_2255408_1	1392491.JIAE01000001_gene1513	6.853e-176	561.0	COG1206@1|root,COG1206@2|Bacteria,1TP67@1239|Firmicutes,24971@186801|Clostridia,3WGA0@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
DEZH2_k127_2265983_1	1121333.JMLH01000107_gene13	8.563e-114	395.0	COG1876@1|root,COG4412@1|root,COG5492@1|root,COG1876@2|Bacteria,COG4412@2|Bacteria,COG5492@2|Bacteria,1V38C@1239|Firmicutes,3VSZQ@526524|Erysipelotrichia	526524|Erysipelotrichia	N	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,ChW,Glug
DEZH2_k127_2265983_0	1384065.JAGS01000001_gene3049	1.041e-231	726.0	COG2272@1|root,COG2272@2|Bacteria,1UXY5@1239|Firmicutes,24CHT@186801|Clostridia,3WHM6@541000|Ruminococcaceae	186801|Clostridia	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
DEZH2_k127_2265983_2	1384066.JAGT01000001_gene229	1.172e-95	315.0	COG3534@1|root,COG3534@2|Bacteria,1TPJ0@1239|Firmicutes,25EH6@186801|Clostridia,3WGC9@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
DEZH2_k127_2289378_0	357809.Cphy_1936	3.796e-246	773.0	COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,2489F@186801|Clostridia,21XH7@1506553|Lachnoclostridium	186801|Clostridia	G	Glycosyl hydrolase family 36 C-terminal domain	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
DEZH2_k127_2289378_1	994573.T472_0219545	4.691e-42	158.0	COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,247VA@186801|Clostridia,36VSN@31979|Clostridiaceae	186801|Clostridia	G	MFS/sugar transport protein	lacS	-	-	ko:K03292,ko:K11104,ko:K16209	-	-	-	-	ko00000,ko02000	2.A.2,2.A.2.1,2.A.2.2	-	-	MFS_2
DEZH2_k127_2315273_15	398512.JQKC01000018_gene2897	4.739e-51	190.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,247WG@186801|Clostridia,3WH24@541000|Ruminococcaceae	186801|Clostridia	I	Carboxyl transferase domain	yqjD	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
DEZH2_k127_2315273_16	1121334.KB911066_gene658	9.643e-29	120.0	COG4770@1|root,COG4770@2|Bacteria,1VA1E@1239|Firmicutes,24MUJ@186801|Clostridia,3WK2X@541000|Ruminococcaceae	186801|Clostridia	I	Biotin-requiring enzyme	gcdC	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
DEZH2_k127_2315273_1	1121335.Clst_1052	1.135e-220	693.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,3WH2N@541000|Ruminococcaceae	186801|Clostridia	C	Pyruvate carboxylase, C-terminal domain subunit K01960	oadA	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
DEZH2_k127_2315273_3	1392491.JIAE01000001_gene1534	7.16e-123	401.0	COG1737@1|root,COG1737@2|Bacteria,1TP7H@1239|Firmicutes,248ZD@186801|Clostridia	186801|Clostridia	K	transcriptional regulator RpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
DEZH2_k127_2315273_14	246194.CHY_1933	6.909e-52	186.0	29CHX@1|root,2ZZGD@2|Bacteria,1V7PD@1239|Firmicutes,24HKB@186801|Clostridia,42GHQ@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM HutP family protein	hutP	-	-	-	-	-	-	-	-	-	-	-	HutP
DEZH2_k127_2315273_12	1392491.JIAE01000001_gene1533	6.474e-67	235.0	COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,24HEF@186801|Clostridia,3WIDU@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
DEZH2_k127_2315273_0	1392491.JIAE01000001_gene1532	6.035e-246	779.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,3WGII@541000|Ruminococcaceae	186801|Clostridia	IJM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
DEZH2_k127_2315273_13	1392491.JIAE01000001_gene1531	1.76e-65	240.0	COG0791@1|root,COG0791@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia,3WHR8@541000|Ruminococcaceae	186801|Clostridia	M	NlpC/P60 family	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SH3_3
DEZH2_k127_2315273_9	1392491.JIAE01000001_gene1528	1.165e-87	305.0	COG0624@1|root,COG0624@2|Bacteria,1TPEG@1239|Firmicutes,247SK@186801|Clostridia,3WHQP@541000|Ruminococcaceae	186801|Clostridia	E	Psort location Cytoplasmic, score	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
DEZH2_k127_2315273_5	699246.HMPREF0868_0945	1.821e-117	384.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia,267MF@186813|unclassified Clostridiales	186801|Clostridia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
DEZH2_k127_2315273_8	699246.HMPREF0868_0944	8.056e-90	300.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,267RB@186813|unclassified Clostridiales	186801|Clostridia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
DEZH2_k127_2315273_4	1410638.JHXJ01000002_gene1395	2.536e-118	384.0	COG0528@1|root,COG0528@2|Bacteria,1TPXN@1239|Firmicutes,247KR@186801|Clostridia,3WGUN@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
DEZH2_k127_2315273_10	1410638.JHXJ01000002_gene1396	2.788e-79	268.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,3WIRX@541000|Ruminococcaceae	186801|Clostridia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
DEZH2_k127_2315273_6	1410638.JHXJ01000002_gene1397	3.537e-104	346.0	COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,3WGF5@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
DEZH2_k127_2315273_11	1392491.JIAE01000001_gene1519	2.746e-70	247.0	COG4589@1|root,COG4589@2|Bacteria,1TT0Q@1239|Firmicutes,25HJP@186801|Clostridia,3WRES@541000|Ruminococcaceae	186801|Clostridia	S	Cytidylyltransferase	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
DEZH2_k127_2315273_2	1392491.JIAE01000001_gene1518	8.519e-132	431.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,2483M@186801|Clostridia,3WGCN@541000|Ruminococcaceae	186801|Clostridia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06420	DXPR_C,DXP_redisom_C,DXP_reductoisom
DEZH2_k127_2315273_7	1392491.JIAE01000001_gene1517	1.563e-95	327.0	COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,3WPTU@541000|Ruminococcaceae	186801|Clostridia	M	Peptidase family M50	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
DEZH2_k127_2337320_2	67267.JNXT01000001_gene5675	9.912e-64	229.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
DEZH2_k127_2337320_1	411468.CLOSCI_00437	1.415e-106	354.0	COG0685@1|root,COG0685@2|Bacteria,1TQFE@1239|Firmicutes,247ZK@186801|Clostridia,21XUA@1506553|Lachnoclostridium	186801|Clostridia	C	Psort location Cytoplasmic, score 8.87	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
DEZH2_k127_2337320_0	1105031.HMPREF1141_0483	1.854e-115	387.0	COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,36FRJ@31979|Clostridiaceae	186801|Clostridia	J	tRNA nucleotidyltransferase poly(A) polymerase	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
DEZH2_k127_2337320_3	536233.CLO_3127	1.857e-26	113.0	COG1725@1|root,COG1725@2|Bacteria,1VA2B@1239|Firmicutes,24N57@186801|Clostridia,36KP5@31979|Clostridiaceae	186801|Clostridia	K	GntR family	-	-	-	-	-	-	-	-	-	-	-	-	GntR
DEZH2_k127_2337320_4	509191.AEDB02000065_gene709	5.071e-25	114.0	COG1191@1|root,COG1191@2|Bacteria,1V5E6@1239|Firmicutes,24I8Q@186801|Clostridia,3WNCS@541000|Ruminococcaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigI	GO:0000988,GO:0000990,GO:0003674,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043254,GO:0044087,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03093	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
DEZH2_k127_2337320_5	997296.PB1_02270	2.024e-06	59.0	2E3R1@1|root,32YNU@2|Bacteria,1VEND@1239|Firmicutes,4HNII@91061|Bacilli,1ZFAW@1386|Bacillus	91061|Bacilli	S	Anti-sigma factor N-terminus	rsgI	-	-	-	-	-	-	-	-	-	-	-	RsgI_N
DEZH2_k127_2339753_5	1392491.JIAE01000001_gene1337	7.087e-38	151.0	COG3025@1|root,COG3025@2|Bacteria,1UYMY@1239|Firmicutes,24Q0T@186801|Clostridia	186801|Clostridia	S	CYTH	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
DEZH2_k127_2339753_2	1347392.CCEZ01000044_gene670	7.739e-95	326.0	COG2081@1|root,COG2081@2|Bacteria,1TR7U@1239|Firmicutes,2497W@186801|Clostridia,36EA5@31979|Clostridiaceae	186801|Clostridia	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
DEZH2_k127_2339753_1	1229517.AMFD01000009_gene816	1.774e-138	458.0	COG2509@1|root,COG2509@2|Bacteria,1TPBW@1239|Firmicutes,4HFIQ@91061|Bacilli,1YB37@1357|Lactococcus	91061|Bacilli	S	FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	-
DEZH2_k127_2339753_4	720554.Clocl_2880	2.4e-48	182.0	COG1234@1|root,COG1234@2|Bacteria,1V1TF@1239|Firmicutes,25CI5@186801|Clostridia,3WK8I@541000|Ruminococcaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	ElaC	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
DEZH2_k127_2339753_6	398512.JQKC01000007_gene1166	3.698e-26	109.0	COG3830@1|root,COG3830@2|Bacteria,1VENW@1239|Firmicutes,24QNV@186801|Clostridia,3WJVR@541000|Ruminococcaceae	186801|Clostridia	T	Belongs to the UPF0237 family	-	-	-	ko:K07166	-	-	-	-	ko00000	-	-	-	ACT_6
DEZH2_k127_2339753_0	1392491.JIAE01000001_gene1341	2.812e-233	727.0	COG2848@1|root,COG2848@2|Bacteria,1TQG8@1239|Firmicutes,247K4@186801|Clostridia,3WGZM@541000|Ruminococcaceae	186801|Clostridia	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
DEZH2_k127_2376451_5	457396.CSBG_01311	1.07e-19	92.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,36DZY@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
DEZH2_k127_2376451_1	1392491.JIAE01000001_gene1202	2.144e-79	274.0	COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,248DE@186801|Clostridia,3WINP@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iHN637.CLJU_RS05465	polyprenyl_synt
DEZH2_k127_2376451_7	935948.KE386495_gene2170	2.1e-10	64.0	COG1722@1|root,COG1722@2|Bacteria,1VK9I@1239|Firmicutes,24UH5@186801|Clostridia,42HHZ@68295|Thermoanaerobacterales	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
DEZH2_k127_2376451_0	1304284.L21TH_0192	8.597e-103	348.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia,36EU5@31979|Clostridiaceae	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
DEZH2_k127_2376451_4	699246.HMPREF0868_1236	1.211e-29	122.0	COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,24MQ3@186801|Clostridia	186801|Clostridia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
DEZH2_k127_2376451_6	1392491.JIAE01000001_gene1198	3.151e-14	74.0	COG5547@1|root,COG5547@2|Bacteria,1VK59@1239|Firmicutes,24UFY@186801|Clostridia	186801|Clostridia	S	Small integral membrane protein (DUF2273)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2273
DEZH2_k127_2376451_2	1392491.JIAE01000001_gene1197	1.775e-64	226.0	COG1302@1|root,COG1302@2|Bacteria,1VF8P@1239|Firmicutes,24R1D@186801|Clostridia,3WK8K@541000|Ruminococcaceae	186801|Clostridia	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
DEZH2_k127_2376451_3	1410638.JHXJ01000002_gene1333	7.044e-43	160.0	COG1302@1|root,COG1302@2|Bacteria,1W1G6@1239|Firmicutes,253WZ@186801|Clostridia	186801|Clostridia	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
DEZH2_k127_2390289_5	1410638.JHXJ01000006_gene2496	5.799e-41	151.0	COG0211@1|root,COG0211@2|Bacteria,1V6HW@1239|Firmicutes,24N3D@186801|Clostridia,3WJU0@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
DEZH2_k127_2390289_1	1392491.JIAE01000001_gene2048	6.233e-155	499.0	COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,3WH1H@541000|Ruminococcaceae	186801|Clostridia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
DEZH2_k127_2390289_6	1410638.JHXJ01000017_gene599	1.821e-24	102.0	COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,3WKG3@541000|Ruminococcaceae	186801|Clostridia	C	PFAM Rubredoxin-type Fe(Cys)4 protein	rubR	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Rubredoxin
DEZH2_k127_2390289_3	699246.HMPREF0868_0695	1.684e-112	377.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,268CF@186813|unclassified Clostridiales	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
DEZH2_k127_2390289_0	1392491.JIAE01000001_gene1933	3.497e-242	753.0	COG0166@1|root,COG0166@2|Bacteria,1TP29@1239|Firmicutes,2487A@186801|Clostridia,3WHJX@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
DEZH2_k127_2390289_4	203119.Cthe_0871	1.508e-43	169.0	COG0135@1|root,COG0135@2|Bacteria,1V6Y0@1239|Firmicutes,24HBQ@186801|Clostridia,3WJH1@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
DEZH2_k127_2390289_2	1392491.JIAE01000001_gene1777	9.354e-136	441.0	COG1032@1|root,COG1032@2|Bacteria,1TR2C@1239|Firmicutes,248HM@186801|Clostridia,3WHME@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DEZH2_k127_2396792_2	357809.Cphy_2655	1.015e-15	81.0	COG0395@1|root,COG0395@2|Bacteria,1TQ9F@1239|Firmicutes,25C58@186801|Clostridia	186801|Clostridia	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
DEZH2_k127_2396792_0	877418.ATWV01000001_gene1742	1.67e-140	452.0	COG4209@1|root,COG4209@2|Bacteria,2J6SZ@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
DEZH2_k127_2396792_1	1392491.JIAE01000001_gene1987	2.591e-39	153.0	COG3250@1|root,COG3250@2|Bacteria,1TQYV@1239|Firmicutes,248PU@186801|Clostridia,3WP7V@541000|Ruminococcaceae	186801|Clostridia	G	Carbohydrate esterase, sialic acid-specific acetylesterase	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_2_N,SASA
DEZH2_k127_240184_2	1392491.JIAE01000001_gene367	6.451e-37	144.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3WGJP@541000|Ruminococcaceae	186801|Clostridia	S	CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
DEZH2_k127_240184_0	1392491.JIAE01000001_gene366	1.53e-228	719.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,3WGCT@541000|Ruminococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
DEZH2_k127_240184_1	1392491.JIAE01000001_gene365	1.066e-65	226.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,3WHW2@541000|Ruminococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
DEZH2_k127_2413972_1	469596.HMPREF9488_03649	1.133e-20	95.0	2FBAG@1|root,343GH@2|Bacteria,1W12N@1239|Firmicutes,3VTZ1@526524|Erysipelotrichia	526524|Erysipelotrichia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2413972_0	755731.Clo1100_0245	5.227e-175	556.0	COG0004@1|root,COG0004@2|Bacteria,1UQ75@1239|Firmicutes,257WC@186801|Clostridia,36G6V@31979|Clostridiaceae	186801|Clostridia	P	Ammonium Transporter	-	-	-	ko:K06580	-	-	-	-	ko00000,ko02000,ko04090	1.A.11.4	-	-	Ammonium_transp
DEZH2_k127_2413972_2	1254432.SCE1572_08105	4.276e-09	61.0	COG2017@1|root,COG2017@2|Bacteria,1MVMN@1224|Proteobacteria,42SM7@68525|delta/epsilon subdivisions,2WP5E@28221|Deltaproteobacteria,2YYGZ@29|Myxococcales	28221|Deltaproteobacteria	G	Converts alpha-aldose to the beta-anomer	galM2	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
DEZH2_k127_2431003_0	644282.Deba_1908	1.025e-155	507.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,42N9T@68525|delta/epsilon subdivisions,2WIMI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
DEZH2_k127_2431003_2	1220534.B655_2114	1.988e-16	83.0	arCOG04899@1|root,arCOG04899@2157|Archaea,2Y1RM@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2431003_1	931276.Cspa_c23720	1.058e-22	102.0	2BCQM@1|root,326B1@2|Bacteria,1W0K9@1239|Firmicutes,24W3A@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2441182_1	697329.Rumal_1463	2.404e-81	281.0	COG1372@1|root,COG3209@1|root,COG1372@2|Bacteria,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia,3WHQ2@541000|Ruminococcaceae	186801|Clostridia	M	RHS repeat-associated core domain	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PT-HINT,RHS_repeat
DEZH2_k127_2441182_0	1392491.JIAE01000001_gene2330	5.706e-208	674.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,3WGTE@541000|Ruminococcaceae	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	EAL,GGDEF,PAS_3,PAS_4,PAS_9
DEZH2_k127_2441182_2	1392491.JIAE01000001_gene2331	1.075e-74	260.0	COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,24864@186801|Clostridia,3WGFD@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
DEZH2_k127_2441182_3	1392491.JIAE01000001_gene2332	2.357e-27	119.0	COG4123@1|root,COG4123@2|Bacteria,1TQ25@1239|Firmicutes,249UH@186801|Clostridia,3WH2K@541000|Ruminococcaceae	186801|Clostridia	S	Methyltransferase small domain	yfiC	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS,Methyltransf_31
DEZH2_k127_247322_6	509191.AEDB02000086_gene2749	4.968e-08	57.0	COG2755@1|root,COG2755@2|Bacteria,1UIB3@1239|Firmicutes,25EG5@186801|Clostridia,3WH87@541000|Ruminococcaceae	186801|Clostridia	E	Carbohydrate esterase, sialic acid-specific acetylesterase	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	CBM27,CBM_35,SASA
DEZH2_k127_247322_4	1392491.JIAE01000001_gene1988	2.344e-36	147.0	COG5578@1|root,COG5578@2|Bacteria,1TV7X@1239|Firmicutes,24QU0@186801|Clostridia	186801|Clostridia	S	Protein of unknown function, DUF624	-	-	-	-	-	-	-	-	-	-	-	-	DUF624
DEZH2_k127_247322_1	1392491.JIAE01000001_gene1990	3.508e-164	523.0	COG1312@1|root,COG1312@2|Bacteria,1TP5F@1239|Firmicutes,247RB@186801|Clostridia,3WGRF@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the dehydration of D-mannonate	uxuA	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
DEZH2_k127_247322_0	1304866.K413DRAFT_2985	2.702e-216	684.0	COG0246@1|root,COG0246@2|Bacteria,1TQ97@1239|Firmicutes,247TG@186801|Clostridia,36E50@31979|Clostridiaceae	186801|Clostridia	G	PFAM Mannitol dehydrogenase, C-terminal domain	-	-	1.1.1.57	ko:K00040	ko00040,ko01100,map00040,map01100	M00061	R02454	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
DEZH2_k127_247322_2	1410638.JHXJ01000005_gene2160	5.402e-86	290.0	COG1802@1|root,COG1802@2|Bacteria,1V3SB@1239|Firmicutes,24EKV@186801|Clostridia,3WM22@541000|Ruminococcaceae	186801|Clostridia	K	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
DEZH2_k127_247322_3	537013.CLOSTMETH_03926	1.4e-37	150.0	COG2135@1|root,COG2135@2|Bacteria,1TRRV@1239|Firmicutes,24GD7@186801|Clostridia,3WK2W@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
DEZH2_k127_2476054_2	1410608.JNKX01000036_gene2298	2.963e-89	303.0	COG0384@1|root,COG0384@2|Bacteria,4PJB2@976|Bacteroidetes,2FTX5@200643|Bacteroidia,4ATX7@815|Bacteroidaceae	976|Bacteroidetes	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
DEZH2_k127_2476054_3	1250232.JQNJ01000001_gene1686	2.863e-45	170.0	COG1247@1|root,COG1247@2|Bacteria,4NNGH@976|Bacteroidetes,1I246@117743|Flavobacteriia	976|Bacteroidetes	M	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
DEZH2_k127_2476054_0	398512.JQKC01000001_gene2326	5.48e-125	406.0	COG2207@1|root,COG2207@2|Bacteria,1TQDS@1239|Firmicutes,24907@186801|Clostridia,3WGSU@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
DEZH2_k127_2476054_1	1410674.JNKU01000043_gene116	1.487e-107	361.0	COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,4H9Z0@91061|Bacilli,3F43R@33958|Lactobacillaceae	91061|Bacilli	F	Carbamoyl-phosphate synthetase glutamine chain	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15510	CPSase_sm_chain,GATase
DEZH2_k127_2476054_4	1121296.JONJ01000001_gene1763	6.266e-42	156.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,2498I@186801|Clostridia,21Y24@1506553|Lachnoclostridium	186801|Clostridia	F	Carbamoylphosphate synthase large subunit	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,DAP_epimerase,MGS
DEZH2_k127_2478651_3	203119.Cthe_0606	4.392e-79	293.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,3WH2S@541000|Ruminococcaceae	186801|Clostridia	S	DNA internalization-related competence protein ComEC Rec2	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
DEZH2_k127_2478651_4	1392491.JIAE01000001_gene1371	1.755e-66	240.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,24ASN@186801|Clostridia,3WH6N@541000|Ruminococcaceae	186801|Clostridia	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
DEZH2_k127_2478651_0	1392491.JIAE01000001_gene1372	1.538e-207	652.0	COG0538@1|root,COG0538@2|Bacteria,1TSKB@1239|Firmicutes,247KX@186801|Clostridia,3WGXI@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the isocitrate and isopropylmalate dehydrogenases family	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DEZH2_k127_2478651_5	1392491.JIAE01000001_gene1373	2.554e-62	218.0	COG3012@1|root,COG3012@2|Bacteria,1V1CC@1239|Firmicutes,24FYC@186801|Clostridia,3WIEI@541000|Ruminococcaceae	186801|Clostridia	S	SEC-C motif	secA_2	-	-	-	-	-	-	-	-	-	-	-	SEC-C
DEZH2_k127_2478651_6	1195236.CTER_0643	1.485e-50	188.0	COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia	186801|Clostridia	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
DEZH2_k127_2478651_2	1410638.JHXJ01000010_gene138	1.413e-86	295.0	COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia,3WKDC@541000|Ruminococcaceae	186801|Clostridia	M	rod shape-determining protein MreC	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
DEZH2_k127_2478651_1	1392491.JIAE01000001_gene1376	7.151e-139	453.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia,3WGCH@541000|Ruminococcaceae	186801|Clostridia	M	Penicillin-binding protein, transpeptidase domain protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
DEZH2_k127_2494221_0	1304880.JAGB01000001_gene423	0.0	1867.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia	186801|Clostridia	G	Glycosyltransferase 36 associated	ndvB	-	-	-	-	-	-	-	-	-	-	-	DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase
DEZH2_k127_2494221_1	358681.BBR47_58260	6.84e-18	98.0	COG0457@1|root,COG2214@1|root,COG0457@2|Bacteria,COG2214@2|Bacteria,1V5Z5@1239|Firmicutes,4HH3V@91061|Bacilli,26U0Q@186822|Paenibacillaceae	91061|Bacilli	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
DEZH2_k127_2495656_7	1294142.CINTURNW_4581	6.565e-37	141.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,36G0N@31979|Clostridiaceae	186801|Clostridia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
DEZH2_k127_2495656_0	1392491.JIAE01000001_gene406	5.581e-205	647.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,3WGU5@541000|Ruminococcaceae	186801|Clostridia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
DEZH2_k127_2495656_3	97138.C820_02415	1.331e-74	259.0	COG1208@1|root,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
DEZH2_k127_2495656_5	906968.Trebr_0641	9.814e-62	226.0	COG0616@1|root,COG0616@2|Bacteria,2J6ZS@203691|Spirochaetes	203691|Spirochaetes	OU	signal peptide peptidase SppA	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
DEZH2_k127_2495656_6	1408321.JNJD01000001_gene95	3.981e-56	216.0	COG0077@1|root,COG0077@2|Bacteria,1TPDN@1239|Firmicutes,248G7@186801|Clostridia,27IIG@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
DEZH2_k127_2495656_8	1123252.ATZF01000001_gene1309	1.24e-36	157.0	COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,4HJ2V@91061|Bacilli,27C0C@186824|Thermoactinomycetaceae	91061|Bacilli	E	Dehydroquinase class II	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
DEZH2_k127_2495656_1	1120746.CCNL01000017_gene3030	4.662e-126	414.0	COG0082@1|root,COG0082@2|Bacteria,2NNQ8@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0663	Chorismate_synt
DEZH2_k127_2495656_2	1410658.JHWI01000007_gene495	5.442e-81	285.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,3VNTA@526524|Erysipelotrichia	526524|Erysipelotrichia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	-	-	-	-	-	-	-	-	-	-	EPSP_synthase
DEZH2_k127_2495656_4	1120746.CCNL01000017_gene3028	1.243e-66	233.0	COG0337@1|root,COG0337@2|Bacteria,2NP5Z@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
DEZH2_k127_2560240_3	699246.HMPREF0868_0845	6.551e-21	93.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia	186801|Clostridia	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_2560240_1	1408823.AXUS01000003_gene502	1.647e-48	185.0	COG4866@1|root,COG4866@2|Bacteria,1TR2J@1239|Firmicutes,2480E@186801|Clostridia,25QVR@186804|Peptostreptococcaceae	186801|Clostridia	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
DEZH2_k127_2560240_2	593117.TGAM_2156	1.69e-22	110.0	COG3919@1|root,arCOG06897@2157|Archaea,2XVV0@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATPgrasp_Ter
DEZH2_k127_2560240_0	1321778.HMPREF1982_01070	9.013e-84	295.0	COG0477@1|root,COG2814@2|Bacteria,1UM9R@1239|Firmicutes,2486D@186801|Clostridia	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DEZH2_k127_2593902_1	502558.EGYY_26600	2.147e-52	193.0	28QIE@1|root,2ZD0E@2|Bacteria,2IHCK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2593902_2	1125725.HMPREF1325_2338	3.091e-19	96.0	COG5403@1|root,COG5403@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
DEZH2_k127_2593902_0	1236973.JCM9157_4362	3.3e-81	276.0	COG2730@1|root,COG2730@2|Bacteria,1TSJQ@1239|Firmicutes,4HFEH@91061|Bacilli,1ZEYQ@1386|Bacillus	91061|Bacilli	G	PFAM glycoside hydrolase family 5	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_17_28,Cellulase,Gram_pos_anchor
DEZH2_k127_2604077_2	622312.ROSEINA2194_03439	1.898e-85	303.0	COG3103@1|root,COG4193@1|root,COG3103@2|Bacteria,COG4193@2|Bacteria,1TRTM@1239|Firmicutes,24C4N@186801|Clostridia	186801|Clostridia	GT	SH3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Dockerin_1,Glucosaminidase,SH3_3
DEZH2_k127_2604077_4	1200557.JHWV01000032_gene2207	3.128e-11	64.0	28RFR@1|root,2ZDUU@2|Bacteria,1W3TE@1239|Firmicutes,4H8JU@909932|Negativicutes	909932|Negativicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2604077_0	1291050.JAGE01000001_gene2697	4.496e-214	674.0	COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,3WGT3@541000|Ruminococcaceae	186801|Clostridia	S	Oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4
DEZH2_k127_2604077_1	1392491.JIAE01000001_gene1171	2.277e-132	433.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,3WGSI@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
DEZH2_k127_2604077_3	1121335.Clst_2306	3.705e-33	131.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,2486F@186801|Clostridia,3WGI2@541000|Ruminococcaceae	186801|Clostridia	O	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03697	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small
DEZH2_k127_2617955_1	509191.AEDB02000065_gene606	3.115e-96	319.0	COG2110@1|root,COG2110@2|Bacteria,1TPCU@1239|Firmicutes,24ARG@186801|Clostridia,3WH35@541000|Ruminococcaceae	186801|Clostridia	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Macro
DEZH2_k127_2617955_0	509191.AEDB02000065_gene605	6.115e-103	338.0	COG2304@1|root,COG2304@2|Bacteria,1TRPP@1239|Firmicutes,249HV@186801|Clostridia,3WI86@541000|Ruminococcaceae	186801|Clostridia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
DEZH2_k127_2617955_3	1123278.KB893439_gene2608	8.651e-07	59.0	COG4767@1|root,COG4767@2|Bacteria	2|Bacteria	V	VanZ like family	vanZ	-	-	-	-	-	-	-	-	-	-	-	VanZ
DEZH2_k127_2617955_2	642492.Clole_0067	4.7e-72	253.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
DEZH2_k127_2633063_0	1392491.JIAE01000001_gene644	2.501e-202	640.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,3WH9M@541000|Ruminococcaceae	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
DEZH2_k127_2633063_1	699246.HMPREF0868_1337	3.967e-136	443.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,267JM@186813|unclassified Clostridiales	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
DEZH2_k127_2658842_0	1392491.JIAE01000001_gene2311	2.443e-264	837.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,3WGKX@541000|Ruminococcaceae	186801|Clostridia	L	ATP-dependent DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
DEZH2_k127_2658842_1	1392491.JIAE01000001_gene2310	2.374e-82	278.0	COG0232@1|root,COG0232@2|Bacteria,1TPEI@1239|Firmicutes,247Q1@186801|Clostridia,3WNBX@541000|Ruminococcaceae	186801|Clostridia	F	Phosphohydrolase-associated domain	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
DEZH2_k127_2661581_4	588581.Cpap_4038	5.001e-25	111.0	COG0454@1|root,COG0454@2|Bacteria,1V78S@1239|Firmicutes,25EW2@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DEZH2_k127_2661581_1	658088.HMPREF0987_01799	1.445e-60	215.0	COG0637@1|root,COG0637@2|Bacteria,1V1DF@1239|Firmicutes,24FYY@186801|Clostridia,27JN1@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
DEZH2_k127_2661581_2	1410617.JHXH01000007_gene1519	8.264e-47	177.0	COG0454@1|root,COG0456@2|Bacteria,1V3VH@1239|Firmicutes,24IGR@186801|Clostridia,3WIXX@541000|Ruminococcaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DEZH2_k127_2661581_0	931626.Awo_c30320	4.554e-142	471.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,25UWR@186806|Eubacteriaceae	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3
DEZH2_k127_2661581_3	203119.Cthe_0234	1.806e-27	114.0	COG0318@1|root,COG1082@1|root,COG0318@2|Bacteria,COG1082@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,3WHKA@541000|Ruminococcaceae	186801|Clostridia	GIQ	AMP-dependent synthetase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C,AP_endonuc_2
DEZH2_k127_267048_6	1410638.JHXJ01000005_gene2144	6.116e-60	215.0	COG1187@1|root,COG1187@2|Bacteria,1TQZ2@1239|Firmicutes,248HC@186801|Clostridia,3WHTI@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rsuA	-	5.4.99.19	ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
DEZH2_k127_267048_11	1392491.JIAE01000001_gene2350	9.825e-26	111.0	2ED8C@1|root,3374X@2|Bacteria,1W0C5@1239|Firmicutes,24S5N@186801|Clostridia,3WR1I@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Smr
DEZH2_k127_267048_3	1121334.KB911070_gene1445	3.067e-67	239.0	COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia,3WIXR@541000|Ruminococcaceae	186801|Clostridia	P	Phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	Big_5,PBP_like_2
DEZH2_k127_267048_1	1120746.CCNL01000010_gene1177	1.038e-102	349.0	COG0573@1|root,COG0573@2|Bacteria,2NPS2@2323|unclassified Bacteria	2|Bacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037,ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
DEZH2_k127_267048_2	537013.CLOSTMETH_01240	2.453e-93	315.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,3WGN2@541000|Ruminococcaceae	186801|Clostridia	P	phosphate ABC transporter	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
DEZH2_k127_267048_0	1120746.CCNL01000010_gene1179	5.691e-124	400.0	COG1117@1|root,COG1117@2|Bacteria,2NP2B@2323|unclassified Bacteria	2|Bacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015114,GO:0015318,GO:0015399,GO:0015405,GO:0015415,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0098660,GO:0098661,GO:0099133	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
DEZH2_k127_267048_8	1378168.N510_03327	2.06e-38	151.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes	1239|Firmicutes	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
DEZH2_k127_267048_5	309803.CTN_0732	1.585e-62	225.0	COG0745@1|root,COG0745@2|Bacteria,2GCK6@200918|Thermotogae	200918|Thermotogae	K	PFAM response regulator receiver	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_267048_7	394503.Ccel_2107	3.303e-57	216.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36DIS@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636,ko:K07652	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
DEZH2_k127_267048_12	1120746.CCNL01000010_gene1182	2.018e-07	53.0	COG5002@1|root,COG5002@2|Bacteria,2NNKK@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	phoR	-	2.7.13.3	ko:K02484,ko:K07636,ko:K07768	ko02020,map02020	M00434,M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
DEZH2_k127_267048_4	1410638.JHXJ01000005_gene2142	3.159e-65	228.0	COG1573@1|root,COG1573@2|Bacteria,1V267@1239|Firmicutes,24DFW@186801|Clostridia,3WIGX@541000|Ruminococcaceae	186801|Clostridia	L	Uracil-DNA glycosylase	udgA	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
DEZH2_k127_267048_10	1120746.CCNL01000005_gene108	1.737e-35	136.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2NPG9@2323|unclassified Bacteria	2|Bacteria	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	cdr	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
DEZH2_k127_2697526_5	1392491.JIAE01000001_gene1053	2.859e-15	78.0	COG0820@1|root,COG0820@2|Bacteria,1TPVF@1239|Firmicutes,248BC@186801|Clostridia,3WGYF@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
DEZH2_k127_2697526_2	1392491.JIAE01000001_gene1052	2.232e-108	366.0	COG0144@1|root,COG0144@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,3WGKM@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
DEZH2_k127_2697526_3	1392491.JIAE01000001_gene1051	3.241e-83	287.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia,3WGPQ@541000|Ruminococcaceae	186801|Clostridia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
DEZH2_k127_2697526_4	1410638.JHXJ01000010_gene122	2.275e-56	200.0	COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,24JET@186801|Clostridia,3WJGJ@541000|Ruminococcaceae	186801|Clostridia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
DEZH2_k127_2697526_1	1392491.JIAE01000001_gene1042	1.507e-195	634.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,3WMZN@541000|Ruminococcaceae	186801|Clostridia	L	helicase superfamily c-terminal domain	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
DEZH2_k127_2697526_0	699246.HMPREF0868_0936	0.0	1215.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,267XE@186813|unclassified Clostridiales	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K02342,ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T
DEZH2_k127_2709379_0	903814.ELI_2346	8.838e-79	269.0	COG0745@1|root,COG0745@2|Bacteria,1TT2Z@1239|Firmicutes,248PN@186801|Clostridia,25W9G@186806|Eubacteriaceae	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_2709379_4	411464.DESPIG_01040	4.727e-10	63.0	COG0778@1|root,COG0778@2|Bacteria,1PDTZ@1224|Proteobacteria,42SQ3@68525|delta/epsilon subdivisions,2WPC5@28221|Deltaproteobacteria,2MB1K@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DEZH2_k127_2709379_3	192952.MM_3268	2.625e-22	99.0	COG0778@1|root,arCOG00288@2157|Archaea,2XYGC@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
DEZH2_k127_2709379_2	386456.JQKN01000002_gene2534	6.659e-52	190.0	arCOG02644@1|root,arCOG02644@2157|Archaea	2157|Archaea	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
DEZH2_k127_2709379_1	1123274.KB899420_gene4054	1.803e-61	223.0	COG1145@1|root,COG1145@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
DEZH2_k127_2709379_5	357809.Cphy_2023	1.907e-06	53.0	COG0330@1|root,COG0330@2|Bacteria,1UY1Y@1239|Firmicutes,24C8M@186801|Clostridia	186801|Clostridia	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
DEZH2_k127_2716570_2	1392491.JIAE01000001_gene1602	2.362e-95	316.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,3WGDM@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
DEZH2_k127_2716570_0	1392491.JIAE01000001_gene1601	2.673e-213	668.0	COG0448@1|root,COG0448@2|Bacteria,1TNZW@1239|Firmicutes,24943@186801|Clostridia,3WGWG@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
DEZH2_k127_2716570_1	1410638.JHXJ01000021_gene2401	1.001e-169	539.0	COG0448@1|root,COG0448@2|Bacteria,1TPZ3@1239|Firmicutes,2482Q@186801|Clostridia,3WGWM@541000|Ruminococcaceae	186801|Clostridia	G	Glucose-1-phosphate adenylyltransferase, GlgD subunit	glgD	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
DEZH2_k127_2716570_3	394503.Ccel_1334	1.025e-11	65.0	COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,248G1@186801|Clostridia,36E5E@31979|Clostridiaceae	186801|Clostridia	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
DEZH2_k127_2717099_2	1123314.AUIO01000002_gene1963	2.17e-09	58.0	COG3534@1|root,COG3534@2|Bacteria,1TPJ0@1239|Firmicutes,4HD18@91061|Bacilli	91061|Bacilli	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
DEZH2_k127_2717099_1	1122179.KB890480_gene3160	1.282e-103	357.0	COG1028@1|root,COG1028@2|Bacteria	1122179.KB890480_gene3160|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2717099_0	1123288.SOV_3c08100	1.523e-143	470.0	COG0642@1|root,COG0834@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,4H30J@909932|Negativicutes	909932|Negativicutes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,HATPase_c,HisKA,Hpt,PAS_8,Response_reg
DEZH2_k127_2719097_0	1469948.JPNB01000001_gene2066	3.071e-181	580.0	COG1061@1|root,COG1061@2|Bacteria,1TRA8@1239|Firmicutes,2481H@186801|Clostridia	186801|Clostridia	V	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	ResIII
DEZH2_k127_2719097_3	1280671.AUJH01000006_gene90	6.052e-32	131.0	COG0454@1|root,COG0456@2|Bacteria,1V7KF@1239|Firmicutes,24K8S@186801|Clostridia,4BZ8M@830|Butyrivibrio	186801|Clostridia	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
DEZH2_k127_2719097_1	485913.Krac_4192	6.471e-72	251.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
DEZH2_k127_2719097_2	1160721.RBI_II00325	2.182e-59	210.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,3WK7S@541000|Ruminococcaceae	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
DEZH2_k127_2720049_3	411902.CLOBOL_04512	4.737e-80	290.0	COG4805@1|root,COG4805@2|Bacteria,1TREN@1239|Firmicutes,249U9@186801|Clostridia,21Y0R@1506553|Lachnoclostridium	186801|Clostridia	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
DEZH2_k127_2720049_2	1410638.JHXJ01000006_gene2594	1.228e-93	315.0	COG1131@1|root,COG1131@2|Bacteria,1UHTY@1239|Firmicutes,24JZH@186801|Clostridia,3WP46@541000|Ruminococcaceae	186801|Clostridia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DEZH2_k127_2720049_1	1392491.JIAE01000001_gene555	2.996e-107	376.0	COG1266@1|root,COG1668@1|root,COG1266@2|Bacteria,COG1668@2|Bacteria,1VA8S@1239|Firmicutes,248TA@186801|Clostridia	186801|Clostridia	CP	CAAX amino terminal protease family	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3,Abi
DEZH2_k127_2720049_5	1514668.JOOA01000002_gene1137	1.096e-64	231.0	COG2159@1|root,COG2159@2|Bacteria,1TRU0@1239|Firmicutes,248VZ@186801|Clostridia,3WIHD@541000|Ruminococcaceae	186801|Clostridia	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
DEZH2_k127_2720049_0	1035308.AQYY01000001_gene3504	1.262e-130	437.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,2608N@186807|Peptococcaceae	186801|Clostridia	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	2.3.1.40,6.2.1.20,6.2.1.3,6.2.1.48	ko:K01897,ko:K02182,ko:K05939	ko00061,ko00071,ko00564,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00564,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280,R01406,R04864	RC00004,RC00014,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
DEZH2_k127_2738401_0	411474.COPEUT_01633	9.804e-229	726.0	COG0855@1|root,COG0855@2|Bacteria,1TNZM@1239|Firmicutes,248XY@186801|Clostridia	186801|Clostridia	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
DEZH2_k127_2740062_2	986075.CathTA2_0957	9.552e-17	84.0	COG3880@1|root,COG3880@2|Bacteria,1V6YM@1239|Firmicutes,4HH4R@91061|Bacilli	91061|Bacilli	S	protein with conserved CXXC pairs	mcsA	GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
DEZH2_k127_2740062_1	1392491.JIAE01000001_gene2610	1.537e-48	177.0	COG4463@1|root,COG4463@2|Bacteria,1VAXT@1239|Firmicutes,24JH3@186801|Clostridia,3WJYG@541000|Ruminococcaceae	186801|Clostridia	K	transcriptional repressor of class III stress genes	ctsR	-	-	ko:K03708	-	-	-	-	ko00000,ko03000	-	-	-	CtsR
DEZH2_k127_2740062_0	1392491.JIAE01000001_gene373	3.771e-106	355.0	COG0791@1|root,COG0791@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia,3WHR8@541000|Ruminococcaceae	186801|Clostridia	M	NlpC/P60 family	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SH3_3
DEZH2_k127_2740062_3	1392491.JIAE01000001_gene372	4.451e-11	64.0	COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,3WGVS@541000|Ruminococcaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
DEZH2_k127_2787498_2	877420.ATVW01000006_gene562	1.039e-91	310.0	COG0834@1|root,COG0834@2|Bacteria,1TT16@1239|Firmicutes,24CEZ@186801|Clostridia,27ITF@186928|unclassified Lachnospiraceae	186801|Clostridia	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
DEZH2_k127_2787498_0	411463.EUBVEN_02039	5.157e-130	423.0	COG0765@1|root,COG0765@2|Bacteria,1TPM3@1239|Firmicutes,248UY@186801|Clostridia,25ZS9@186806|Eubacteriaceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
DEZH2_k127_2787498_1	877420.ATVW01000006_gene564	3.816e-118	384.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia,27IAG@186928|unclassified Lachnospiraceae	186801|Clostridia	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
DEZH2_k127_2787498_3	877455.Metbo_1852	0.0007365	43.0	arCOG10865@1|root,arCOG10865@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2808699_1	383372.Rcas_2537	3.598e-86	312.0	COG0577@1|root,COG0577@2|Bacteria,2G68F@200795|Chloroflexi,376ZY@32061|Chloroflexia	32061|Chloroflexia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DEZH2_k127_2808699_0	1408415.JHXL01000001_gene417	4.816e-102	338.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	ant	-	2.7.7.47	ko:K00984,ko:K19279	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	DUF4111,NTP_transf_2,UPF0158
DEZH2_k127_2808699_2	536227.CcarbDRAFT_0475	2.044e-36	139.0	2DNZB@1|root,32ZW6@2|Bacteria,1VB2I@1239|Firmicutes,24R5F@186801|Clostridia,36NJ3@31979|Clostridiaceae	186801|Clostridia	S	Cysteine-rich CPCC	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CPCC
DEZH2_k127_2808699_4	552396.HMPREF0863_01005	1.917e-18	95.0	2E170@1|root,32WMV@2|Bacteria,1VD9Y@1239|Firmicutes,3VRPY@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Domain of unknown function (DUF4299)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4299
DEZH2_k127_2808699_3	1214184.ALKY01000017_gene459	2.942e-33	135.0	29R0W@1|root,30C20@2|Bacteria,1U90Y@1239|Firmicutes,4IJ10@91061|Bacilli,1WTB9@1307|Streptococcus suis	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2872041_1	1410650.JHWL01000014_gene540	0.00074	51.0	COG4709@1|root,COG4709@2|Bacteria,1V9T7@1239|Firmicutes,24KZN@186801|Clostridia	186801|Clostridia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1700
DEZH2_k127_2872041_0	675815.VOA_001478	1.677e-33	143.0	28MZ6@1|root,2Z9YX@2|Bacteria,1NEBB@1224|Proteobacteria,1SND4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2
DEZH2_k127_2885247_1	1321778.HMPREF1982_00683	1.373e-34	136.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,26837@186813|unclassified Clostridiales	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
DEZH2_k127_2885247_3	1392491.JIAE01000001_gene1094	4.773e-30	129.0	COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,24MQF@186801|Clostridia,3WM12@541000|Ruminococcaceae	186801|Clostridia	L	TIGRFAM competence protein ComEA helix-hairpin-helix repeat	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
DEZH2_k127_2885247_0	1392491.JIAE01000001_gene1093	1.286e-38	155.0	COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,24MVA@186801|Clostridia,3WJVU@541000|Ruminococcaceae	186801|Clostridia	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
DEZH2_k127_2885247_2	1392491.JIAE01000001_gene1091	4.184e-33	139.0	COG1057@1|root,COG1713@1|root,COG1057@2|Bacteria,COG1713@2|Bacteria,1V6Y1@1239|Firmicutes,24HN2@186801|Clostridia,3WJZX@541000|Ruminococcaceae	186801|Clostridia	H	HD superfamily hydrolase involved in NAD metabolism	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,HD
DEZH2_k127_2888088_2	1392491.JIAE01000001_gene1085	2.132e-37	143.0	COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,24HCB@186801|Clostridia,3WITM@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
DEZH2_k127_2888088_0	1392491.JIAE01000001_gene1084	9.863e-101	341.0	COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,25CHR@186801|Clostridia,3WIX2@541000|Ruminococcaceae	186801|Clostridia	M	Bacterial capsule synthesis protein PGA_cap	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap,Peptidase_M15
DEZH2_k127_2888088_1	411462.DORLON_02090	6.229e-92	306.0	COG1207@1|root,COG1207@2|Bacteria,1UGTD@1239|Firmicutes,25PCV@186801|Clostridia,27VED@189330|Dorea	186801|Clostridia	M	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
DEZH2_k127_2906537_1	515620.EUBELI_01738	7.593e-65	236.0	COG2843@1|root,COG2843@2|Bacteria,1V20N@1239|Firmicutes,24AI2@186801|Clostridia,25WZI@186806|Eubacteriaceae	186801|Clostridia	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
DEZH2_k127_2906537_2	1410638.JHXJ01000015_gene2450	5.103e-27	122.0	2CZNZ@1|root,32T6S@2|Bacteria,1UMAD@1239|Firmicutes,24IBZ@186801|Clostridia	186801|Clostridia	S	TPM domain	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
DEZH2_k127_2906537_0	1410638.JHXJ01000015_gene2449	4.097e-78	275.0	COG1996@1|root,COG1996@2|Bacteria,1UI9I@1239|Firmicutes,248XK@186801|Clostridia,3WHNV@541000|Ruminococcaceae	186801|Clostridia	K	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_2917762_3	357809.Cphy_0561	6.588e-42	160.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,22038@1506553|Lachnoclostridium	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
DEZH2_k127_2917762_4	632245.CLP_0490	1.093e-09	60.0	COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,24AKE@186801|Clostridia,36E8Z@31979|Clostridiaceae	186801|Clostridia	P	Periplasmic binding protein	yvrC	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
DEZH2_k127_2917762_1	1392491.JIAE01000001_gene552	5.992e-66	235.0	COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,24AKE@186801|Clostridia,3WJ51@541000|Ruminococcaceae	186801|Clostridia	P	Periplasmic binding protein	yvrC	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
DEZH2_k127_2917762_0	1216932.CM240_3074	1.757e-89	305.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
DEZH2_k127_2917762_2	994573.T472_0215635	2.565e-65	228.0	COG1116@1|root,COG1116@2|Bacteria,1VAD8@1239|Firmicutes,24GFE@186801|Clostridia,36JUX@31979|Clostridiaceae	186801|Clostridia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
DEZH2_k127_2927747_1	1392491.JIAE01000001_gene1407	3.7e-35	134.0	COG0312@1|root,COG0312@2|Bacteria,1TSQC@1239|Firmicutes,248MD@186801|Clostridia,3WNE0@541000|Ruminococcaceae	186801|Clostridia	S	Putative modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
DEZH2_k127_2927747_0	1292035.H476_2319	2.937e-108	366.0	COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,24AGW@186801|Clostridia,25S3A@186804|Peptostreptococcaceae	186801|Clostridia	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
DEZH2_k127_2940019_2	1121335.Clst_0576	1.252e-92	312.0	COG3534@1|root,COG3534@2|Bacteria,1TR7B@1239|Firmicutes,248ZA@186801|Clostridia,3WGAE@541000|Ruminococcaceae	186801|Clostridia	G	Alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
DEZH2_k127_2940019_3	397287.C807_03291	1.403e-32	136.0	COG5578@1|root,COG5578@2|Bacteria,1V3XD@1239|Firmicutes,24K78@186801|Clostridia,27MVA@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Protein of unknown function, DUF624	-	-	-	-	-	-	-	-	-	-	-	-	DUF624
DEZH2_k127_2940019_1	357809.Cphy_3212	1.685e-126	426.0	COG2972@1|root,COG2972@2|Bacteria,1UY4H@1239|Firmicutes,249VT@186801|Clostridia,21XT2@1506553|Lachnoclostridium	186801|Clostridia	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
DEZH2_k127_2940019_0	357809.Cphy_3211	7.748e-147	483.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UYCG@1239|Firmicutes,24DKG@186801|Clostridia	186801|Clostridia	T	helix-turn-helix- domain containing protein, AraC type	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
DEZH2_k127_2959206_0	1177154.Y5S_03236	7.703e-16	81.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1XI1E@135619|Oceanospirillales	135619|Oceanospirillales	V	Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K05685	ko02010,map02010	M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
DEZH2_k127_2967790_2	1392491.JIAE01000001_gene1516	6.371e-39	154.0	COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia,3WH36@541000|Ruminococcaceae	186801|Clostridia	O	chelatase subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
DEZH2_k127_2967790_1	1392491.JIAE01000001_gene1515	1.509e-69	250.0	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,3WIM4@541000|Ruminococcaceae	186801|Clostridia	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
DEZH2_k127_2967790_0	1410638.JHXJ01000013_gene2290	6.849e-86	289.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,3WGDZ@541000|Ruminococcaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
DEZH2_k127_2967790_3	911045.PSE_2994	9.222e-12	65.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS2I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
DEZH2_k127_2969975_0	332101.JIBU02000089_gene4134	1.448e-55	201.0	COG1073@1|root,COG1073@2|Bacteria,1UF81@1239|Firmicutes,24BZ7@186801|Clostridia,36FH3@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF2974)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2974
DEZH2_k127_2969975_1	1216932.CM240_2844	6.471e-55	200.0	COG3619@1|root,COG3619@2|Bacteria,1V1VQ@1239|Firmicutes,24DUE@186801|Clostridia,36HTU@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1275)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1275
DEZH2_k127_2969975_2	1341157.RF007C_07505	7.421e-53	195.0	COG1434@1|root,COG1434@2|Bacteria,1VA42@1239|Firmicutes,24HKK@186801|Clostridia,3WIGF@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
DEZH2_k127_2969975_3	203119.Cthe_0873	1.66e-25	108.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,3WHFS@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
DEZH2_k127_2999046_0	1392491.JIAE01000001_gene1138	0.0	1025.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,3WGW6@541000|Ruminococcaceae	186801|Clostridia	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
DEZH2_k127_2999046_1	1410638.JHXJ01000013_gene2281	6.925e-12	66.0	COG0749@1|root,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,3WGRT@541000|Ruminococcaceae	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
DEZH2_k127_3012690_0	1392491.JIAE01000001_gene1279	2.409e-99	334.0	COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,3WG85@541000|Ruminococcaceae	186801|Clostridia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iHN637.CLJU_RS20420	Mur_ligase_C,Mur_ligase_M
DEZH2_k127_3012690_1	428125.CLOLEP_01075	5.947e-80	273.0	COG0398@1|root,COG0398@2|Bacteria,1V3DJ@1239|Firmicutes,24G6T@186801|Clostridia,3WK86@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
DEZH2_k127_3012690_2	1280663.ATVR01000049_gene3067	1.563e-14	77.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,4BWCU@830|Butyrivibrio	186801|Clostridia	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
DEZH2_k127_3071040_2	1236976.JCM16418_2882	7.444e-12	70.0	COG2909@1|root,COG2909@2|Bacteria,1UIMV@1239|Firmicutes,4HD7H@91061|Bacilli,26QDM@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
DEZH2_k127_3071040_1	1121335.Clst_1688	1.873e-74	253.0	COG0716@1|root,COG0716@2|Bacteria,1UMX6@1239|Firmicutes,25GRG@186801|Clostridia	186801|Clostridia	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3071040_0	2754.EH55_11605	1.35e-167	532.0	COG3177@1|root,COG3177@2|Bacteria,3TBYJ@508458|Synergistetes	508458|Synergistetes	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
DEZH2_k127_3076001_0	1392491.JIAE01000001_gene1586	3.358e-87	295.0	COG0116@1|root,COG0116@2|Bacteria,1TP0X@1239|Firmicutes,248MA@186801|Clostridia,3WGN5@541000|Ruminococcaceae	186801|Clostridia	L	Belongs to the methyltransferase superfamily	ypsC	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
DEZH2_k127_3076001_1	1045858.Bint_0319	1.817e-73	257.0	COG0657@1|root,COG0657@2|Bacteria,2J8DY@203691|Spirochaetes	203691|Spirochaetes	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
DEZH2_k127_3076001_2	702450.CUW_2701	1.724e-53	198.0	COG4905@1|root,COG4905@2|Bacteria,1TQUM@1239|Firmicutes,3VQW4@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Putative ABC-transporter type IV	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_CmpB
DEZH2_k127_3093116_1	1449126.JQKL01000079_gene3092	6.349e-112	371.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	mshQ	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Bactofilin,H_lectin,Laminin_G_3
DEZH2_k127_3093116_0	1449126.JQKL01000079_gene3091	5.584e-183	580.0	COG1215@1|root,COG1215@2|Bacteria,1TRCI@1239|Firmicutes,25BAQ@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase family 2	ydaM	-	2.4.1.336	ko:K19003	ko00561,ko01100,map00561,map01100	-	R02689	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glyco_tranf_2_3,Glycos_transf_2
DEZH2_k127_3093116_3	1262914.BN533_00011	1.622e-39	157.0	2E5DD@1|root,3305D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3093116_2	756499.Desde_0741	1.149e-95	322.0	COG0508@1|root,COG0508@2|Bacteria,1V9QA@1239|Firmicutes,24KV2@186801|Clostridia,265UJ@186807|Peptococcaceae	186801|Clostridia	C	dehydrogenase complex catalyzes the overall conversion of	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
DEZH2_k127_3096353_2	699246.HMPREF0868_1325	3.233e-92	305.0	COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,267KY@186813|unclassified Clostridiales	186801|Clostridia	CH	Psort location Cytoplasmic, score 9.97	nfnA	-	1.18.1.2,1.19.1.1	ko:K00528,ko:K16951	ko00920,ko01120,map00920,map01120	-	R00858,R10146,R10159	RC00065	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
DEZH2_k127_3096353_0	537013.CLOSTMETH_03095	3.606e-227	711.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3WGEA@541000|Ruminococcaceae	186801|Clostridia	C	glutamate synthase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
DEZH2_k127_3096353_1	610130.Closa_1790	1.873e-112	371.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia,21Y5B@1506553|Lachnoclostridium	186801|Clostridia	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	hprA	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
DEZH2_k127_3096353_3	394503.Ccel_0673	1.669e-77	264.0	COG0451@1|root,COG0451@2|Bacteria,1TPYA@1239|Firmicutes,24A39@186801|Clostridia,36GZF@31979|Clostridiaceae	186801|Clostridia	GM	epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
DEZH2_k127_3132443_3	203119.Cthe_2085	1.618e-49	180.0	COG0756@1|root,COG0756@2|Bacteria,1V6HX@1239|Firmicutes,24K3X@186801|Clostridia	186801|Clostridia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
DEZH2_k127_3132443_0	1392491.JIAE01000001_gene1414	7.397e-131	424.0	COG0598@1|root,COG0598@2|Bacteria,1TPI8@1239|Firmicutes,24956@186801|Clostridia,3WGVT@541000|Ruminococcaceae	186801|Clostridia	P	Mg2 transporter protein CorA family protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
DEZH2_k127_3132443_1	1392491.JIAE01000001_gene1413	1.869e-101	340.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,249J1@186801|Clostridia,3WHEU@541000|Ruminococcaceae	186801|Clostridia	S	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Peptidase_S9
DEZH2_k127_3132443_2	545694.TREPR_0314	6.737e-54	199.0	COG1968@1|root,COG1968@2|Bacteria,2J5SC@203691|Spirochaetes	203691|Spirochaetes	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
DEZH2_k127_3132443_4	1410638.JHXJ01000013_gene2336	2.248e-28	115.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,3WGP5@541000|Ruminococcaceae	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
DEZH2_k127_3142356_4	1392491.JIAE01000001_gene1091	1.909e-43	167.0	COG1057@1|root,COG1713@1|root,COG1057@2|Bacteria,COG1713@2|Bacteria,1V6Y1@1239|Firmicutes,24HN2@186801|Clostridia,3WJZX@541000|Ruminococcaceae	186801|Clostridia	H	HD superfamily hydrolase involved in NAD metabolism	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,HD
DEZH2_k127_3142356_1	1410638.JHXJ01000007_gene1083	1.991e-183	582.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,3WGPD@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
DEZH2_k127_3142356_0	1291050.JAGE01000001_gene339	8.055e-208	658.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,3WHMW@541000|Ruminococcaceae	186801|Clostridia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS04230	AICARFT_IMPCHas,MGS
DEZH2_k127_3142356_3	1410638.JHXJ01000030_gene277	5.527e-76	260.0	COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,3WIAG@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04225	Formyl_trans_N
DEZH2_k127_3142356_2	1410638.JHXJ01000030_gene276	5.844e-160	517.0	COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia,3WH6T@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
DEZH2_k127_3142356_5	1392491.JIAE01000001_gene1085	4.056e-33	131.0	COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,24HCB@186801|Clostridia,3WITM@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
DEZH2_k127_317151_0	332101.JIBU02000089_gene4134	5.326e-84	286.0	COG1073@1|root,COG1073@2|Bacteria,1UF81@1239|Firmicutes,24BZ7@186801|Clostridia,36FH3@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF2974)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2974
DEZH2_k127_317151_3	582515.KR51_00025410	2.454e-05	50.0	COG0590@1|root,COG0590@2|Bacteria,1G6ZU@1117|Cyanobacteria	1117|Cyanobacteria	FJ	deaminase zinc-binding	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
DEZH2_k127_317151_1	1410653.JHVC01000014_gene3416	1.451e-48	182.0	COG1595@1|root,COG1595@2|Bacteria,1V8GV@1239|Firmicutes,24JEH@186801|Clostridia,36VT3@31979|Clostridiaceae	186801|Clostridia	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
DEZH2_k127_317151_2	658086.HMPREF0994_05449	8.966e-10	61.0	2DT1N@1|root,33I9R@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
DEZH2_k127_3202641_2	756499.Desde_1609	6.275e-59	211.0	COG1668@1|root,COG1668@2|Bacteria,1V2WV@1239|Firmicutes,24IFP@186801|Clostridia,265X0@186807|Peptococcaceae	186801|Clostridia	CP	transmembrane transport	-	-	-	ko:K16906	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	-
DEZH2_k127_3202641_1	33035.JPJF01000016_gene4068	1.078e-65	231.0	2DBXG@1|root,2ZBPJ@2|Bacteria,1UHVI@1239|Firmicutes,24DRU@186801|Clostridia	186801|Clostridia	-	-	-	-	-	ko:K16905	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	-
DEZH2_k127_3202641_0	1122143.AUEG01000015_gene1854	3.298e-99	333.0	COG1846@1|root,COG1846@2|Bacteria,1TSQ4@1239|Firmicutes	1239|Firmicutes	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	MarR
DEZH2_k127_3203296_0	642492.Clole_0691	3.705e-154	493.0	COG1175@1|root,COG1175@2|Bacteria,1TR2A@1239|Firmicutes,247MA@186801|Clostridia	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
DEZH2_k127_3203296_1	642492.Clole_0692	2.666e-84	287.0	COG3833@1|root,COG3833@2|Bacteria,1TRB7@1239|Firmicutes,248A7@186801|Clostridia	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15772	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
DEZH2_k127_3209161_0	1410638.JHXJ01000002_gene1339	4.542e-152	497.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,3WGVF@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
DEZH2_k127_3209161_1	1392491.JIAE01000001_gene1204	1.508e-80	278.0	COG0061@1|root,COG0061@2|Bacteria,1TRB3@1239|Firmicutes,24BG6@186801|Clostridia,3WPH8@541000|Ruminococcaceae	186801|Clostridia	G	ATP-NAD kinase	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS05480	NAD_kinase
DEZH2_k127_3209161_3	1540257.JQMW01000009_gene3336	6.285e-27	115.0	COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,24HGQ@186801|Clostridia,36IRA@31979|Clostridiaceae	186801|Clostridia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
DEZH2_k127_3209161_2	720554.Clocl_2035	1.486e-63	231.0	COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia,3WHDP@541000|Ruminococcaceae	186801|Clostridia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
DEZH2_k127_3226200_5	1392491.JIAE01000001_gene1787	2.675e-45	170.0	COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,248DV@186801|Clostridia,3WIQ9@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
DEZH2_k127_3226200_4	1392491.JIAE01000001_gene1790	1.007e-54	193.0	COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia,3WIYY@541000|Ruminococcaceae	186801|Clostridia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
DEZH2_k127_3226200_7	1392491.JIAE01000001_gene1791	1.857e-24	103.0	COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia,3WKXA@541000|Ruminococcaceae	186801|Clostridia	J	Ribosomal protein L35	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
DEZH2_k127_3226200_2	1392491.JIAE01000001_gene1792	2.778e-64	226.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,3WIZW@541000|Ruminococcaceae	186801|Clostridia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
DEZH2_k127_3226200_0	1392491.JIAE01000001_gene1793	3.303e-158	508.0	COG0436@1|root,COG0436@2|Bacteria,1TP36@1239|Firmicutes,248ZV@186801|Clostridia,3WH96@541000|Ruminococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	yhdR	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
DEZH2_k127_3226200_8	203119.Cthe_0577	3.824e-23	108.0	COG1564@1|root,COG1564@2|Bacteria,1VA0W@1239|Firmicutes,24NG6@186801|Clostridia,3WJUT@541000|Ruminococcaceae	186801|Clostridia	H	thiamine pyrophosphokinase	thiN	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
DEZH2_k127_3226200_3	1410638.JHXJ01000010_gene115	3.171e-61	218.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,3WISD@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
DEZH2_k127_3226200_1	1392491.JIAE01000001_gene1056	1.072e-75	264.0	COG1162@1|root,COG1162@2|Bacteria,1TPSQ@1239|Firmicutes,248R5@186801|Clostridia,3WGGY@541000|Ruminococcaceae	186801|Clostridia	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
DEZH2_k127_3226200_6	1410638.JHXJ01000010_gene117	4.996e-45	175.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3WGK8@541000|Ruminococcaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
DEZH2_k127_3256944_5	720554.Clocl_0719	3.242e-08	60.0	2DZQA@1|root,32VG4@2|Bacteria,1VJRY@1239|Firmicutes,24PSN@186801|Clostridia,3WM87@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3256944_3	706433.HMPREF9430_01174	1.292e-39	149.0	COG3877@1|root,COG3877@2|Bacteria,1VGSH@1239|Firmicutes	1239|Firmicutes	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
DEZH2_k127_3256944_4	545697.HMPREF0216_02333	1.715e-39	162.0	COG1680@1|root,COG1680@2|Bacteria,1TRR5@1239|Firmicutes,249KP@186801|Clostridia,36H4V@31979|Clostridiaceae	186801|Clostridia	V	beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase,Cu_amine_oxidN1,DUF3471
DEZH2_k127_3256944_0	642492.Clole_0518	5.624e-125	432.0	COG1653@1|root,COG3693@1|root,COG1653@2|Bacteria,COG3693@2|Bacteria,1UHTC@1239|Firmicutes,248KD@186801|Clostridia	1239|Firmicutes	G	PFAM glycoside hydrolase, family 10	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	CBM9_1,CBM_4_9,CW_binding_1,Glyco_hydro_10
DEZH2_k127_3256944_2	580331.Thit_0197	5.87e-94	316.0	COG0395@1|root,COG0395@2|Bacteria,1TS0R@1239|Firmicutes,248UX@186801|Clostridia,42I92@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
DEZH2_k127_3256944_1	857293.CAAU_0150	1.51e-100	338.0	COG1175@1|root,COG1175@2|Bacteria,1TS63@1239|Firmicutes,2489M@186801|Clostridia,36H73@31979|Clostridiaceae	186801|Clostridia	G	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
DEZH2_k127_3275455_0	755731.Clo1100_3403	6.003e-156	501.0	COG0446@1|root,COG0446@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36EYM@31979|Clostridiaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Pyr_redox_dim,Rhodanese
DEZH2_k127_3275455_1	696281.Desru_1493	2.747e-122	397.0	COG1741@1|root,COG1741@2|Bacteria,1TQDV@1239|Firmicutes,2497R@186801|Clostridia,263S8@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
DEZH2_k127_3275455_3	931626.Awo_c23060	1.271e-70	247.0	COG1145@1|root,COG1145@2|Bacteria,1UI80@1239|Firmicutes,25ED6@186801|Clostridia,25WYR@186806|Eubacteriaceae	186801|Clostridia	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Flavodoxin_5
DEZH2_k127_3275455_2	796945.HMPREF1145_0781	5.426e-96	316.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,2PRGP@265975|Oribacterium	186801|Clostridia	P	ABC transporter, ATP-binding protein	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
DEZH2_k127_3339055_3	1410638.JHXJ01000033_gene21	0.0001746	44.0	COG0227@1|root,COG0227@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
DEZH2_k127_3339055_1	1487921.DP68_09320	1.01e-68	242.0	COG1143@1|root,COG2878@1|root,COG1143@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,24904@186801|Clostridia,36FC4@31979|Clostridiaceae	186801|Clostridia	C	electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_13,Fer4_4,Fer4_9
DEZH2_k127_3339055_0	411467.BACCAP_01364	5.908e-69	239.0	COG4657@1|root,COG4657@2|Bacteria,1TS06@1239|Firmicutes,247UE@186801|Clostridia,268RC@186813|unclassified Clostridiales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
DEZH2_k127_3339055_2	1158607.UAU_01126	6.548e-14	75.0	COG4660@1|root,COG4660@2|Bacteria,1TSE7@1239|Firmicutes,4HXR7@91061|Bacilli,4AZWJ@81852|Enterococcaceae	91061|Bacilli	U	Part of a membrane complex involved in electron transport	-	-	-	-	-	-	-	-	-	-	-	-	Rnf-Nqr
DEZH2_k127_3350394_4	693746.OBV_25530	2.743e-51	196.0	COG0582@1|root,COG0582@2|Bacteria,1V4ZP@1239|Firmicutes,24IPR@186801|Clostridia,2N87Q@216572|Oscillospiraceae	186801|Clostridia	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
DEZH2_k127_3350394_2	428125.CLOLEP_02571	9.028e-65	231.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,3WHZV@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
DEZH2_k127_3350394_6	1449050.JNLE01000003_gene926	6.971e-41	159.0	COG4684@1|root,COG4684@2|Bacteria,1V2ZW@1239|Firmicutes	1239|Firmicutes	S	ECF transporter, substrate-specific component	-	-	-	-	-	-	-	-	-	-	-	-	ECF_trnsprt
DEZH2_k127_3350394_7	580327.Tthe_1243	3.731e-30	124.0	COG0021@1|root,COG0021@2|Bacteria,1TPIB@1239|Firmicutes,25E6C@186801|Clostridia,42JGE@68295|Thermoanaerobacterales	186801|Clostridia	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
DEZH2_k127_3350394_9	1121342.AUCO01000014_gene1870	1.041e-24	109.0	COG0021@1|root,COG0021@2|Bacteria,1TPIB@1239|Firmicutes,25E6C@186801|Clostridia,36UJ4@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
DEZH2_k127_3350394_11	1216932.CM240_2880	1.614e-10	62.0	COG0693@1|root,COG0693@2|Bacteria,1UST6@1239|Firmicutes,24BUS@186801|Clostridia,36I0S@31979|Clostridiaceae	186801|Clostridia	K	DJ-1/PfpI family	-	-	3.5.1.124	ko:K03152	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
DEZH2_k127_3350394_12	642492.Clole_0155	4.378e-09	57.0	COG0693@1|root,COG0693@2|Bacteria,1UST6@1239|Firmicutes,24BUS@186801|Clostridia	186801|Clostridia	K	DJ-1/PfpI family	-	-	3.5.1.124	ko:K03152	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
DEZH2_k127_3350394_3	97138.C820_00674	8.345e-57	205.0	COG5587@1|root,COG5587@2|Bacteria,1V7J6@1239|Firmicutes,25DZV@186801|Clostridia	186801|Clostridia	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
DEZH2_k127_3350394_10	537013.CLOSTMETH_00643	5.176e-13	70.0	2APNN@1|root,31ES7@2|Bacteria,1V7W5@1239|Firmicutes,24GHR@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3350394_5	1243664.CAVL020000054_gene3116	6.315e-42	165.0	COG1396@1|root,COG1396@2|Bacteria,1UM3W@1239|Firmicutes,4IUHF@91061|Bacilli	91061|Bacilli	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
DEZH2_k127_3350394_0	448385.sce0244	2.273e-160	525.0	COG1226@1|root,COG1226@2|Bacteria,1MV0T@1224|Proteobacteria,43DUN@68525|delta/epsilon subdivisions,2WYXG@28221|Deltaproteobacteria,2Z0V5@29|Myxococcales	28221|Deltaproteobacteria	P	Castor and Pollux, part of voltage-gated ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Castor_Poll_mid
DEZH2_k127_3350394_1	1304866.K413DRAFT_4566	2.988e-127	411.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,36DJ4@31979|Clostridiaceae	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
DEZH2_k127_3350394_8	552811.Dehly_1323	2.161e-28	117.0	COG0704@1|root,COG0704@2|Bacteria,2G6HD@200795|Chloroflexi,34D3P@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
DEZH2_k127_3352174_0	1254432.SCE1572_21215	5.427e-131	449.0	COG2730@1|root,COG2730@2|Bacteria,1R2BZ@1224|Proteobacteria	1224|Proteobacteria	G	Glycoside hydrolase family 44	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_44
DEZH2_k127_3352174_3	397288.C806_00448	1.653e-33	130.0	COG3077@1|root,COG3077@2|Bacteria,1VEDW@1239|Firmicutes,24QJN@186801|Clostridia,27PJ4@186928|unclassified Lachnospiraceae	186801|Clostridia	L	RelB antitoxin	-	-	-	ko:K07473	-	-	-	-	ko00000,ko02048	-	-	-	RelB
DEZH2_k127_3352174_1	1410668.JNKC01000001_gene1749	2.338e-53	192.0	COG4894@1|root,COG4894@2|Bacteria,1V3WA@1239|Firmicutes,24MB0@186801|Clostridia,36KCK@31979|Clostridiaceae	186801|Clostridia	S	LURP-one-related	-	-	-	-	-	-	-	-	-	-	-	-	LOR
DEZH2_k127_3352174_2	1403313.AXBR01000024_gene4710	5.91e-47	174.0	COG1595@1|root,COG1595@2|Bacteria,1UZSS@1239|Firmicutes,4HJ8P@91061|Bacilli,1ZH1D@1386|Bacillus	91061|Bacilli	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DEZH2_k127_3352174_4	1408422.JHYF01000008_gene3686	7.849e-13	75.0	COG5660@1|root,COG5660@2|Bacteria,1VKXY@1239|Firmicutes,24UK9@186801|Clostridia,36NY6@31979|Clostridiaceae	186801|Clostridia	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
DEZH2_k127_3371513_1	699246.HMPREF0868_0471	2.98e-83	288.0	COG3869@1|root,COG3869@2|Bacteria,1TPBA@1239|Firmicutes,247SS@186801|Clostridia,268PQ@186813|unclassified Clostridiales	186801|Clostridia	H	ATP:guanido phosphotransferase, C-terminal catalytic domain	mcsB	-	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
DEZH2_k127_3371513_0	632518.Calow_1569	1.21e-199	640.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,42FKB@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
DEZH2_k127_3373092_2	32057.KB217478_gene2534	0.0001147	45.0	COG1404@1|root,COG1404@2|Bacteria,1G67C@1117|Cyanobacteria,1HMY2@1161|Nostocales	1117|Cyanobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DEZH2_k127_3373092_1	1392491.JIAE01000001_gene1943	4.071e-18	94.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
DEZH2_k127_3373092_0	1392491.JIAE01000001_gene1944	1.527e-31	128.0	2911U@1|root,2ZNPD@2|Bacteria,1W5JX@1239|Firmicutes,256U0@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF1292)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1292
DEZH2_k127_3398010_0	1120746.CCNL01000005_gene108	4.283e-207	655.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2NPG9@2323|unclassified Bacteria	2|Bacteria	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	cdr	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
DEZH2_k127_3426120_0	1392491.JIAE01000001_gene1594	1.345e-123	401.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,3WGY5@541000|Ruminococcaceae	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
DEZH2_k127_3426120_1	1392491.JIAE01000001_gene1593	2.837e-69	240.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,3WPKP@541000|Ruminococcaceae	186801|Clostridia	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
DEZH2_k127_3426120_2	1392491.JIAE01000001_gene1749	3.192e-50	182.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,3WJJS@541000|Ruminococcaceae	186801|Clostridia	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
DEZH2_k127_3426120_3	1392491.JIAE01000001_gene1748	5.607e-41	154.0	COG4100@1|root,COG4100@2|Bacteria,1TQ88@1239|Firmicutes,247Y4@186801|Clostridia,3WGF6@541000|Ruminococcaceae	186801|Clostridia	P	Cystathionine beta-lyase family protein involved in aluminum resistance	ynbB	-	-	-	-	-	-	-	-	-	-	-	Met_gamma_lyase
DEZH2_k127_3445616_4	1410638.JHXJ01000010_gene160	3.718e-82	278.0	COG0846@1|root,COG0846@2|Bacteria,1TQKD@1239|Firmicutes,2491J@186801|Clostridia,3WGSY@541000|Ruminococcaceae	186801|Clostridia	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
DEZH2_k127_3445616_2	86416.Clopa_1407	1.864e-110	379.0	COG0249@1|root,COG0249@2|Bacteria,1TPJP@1239|Firmicutes,247IW@186801|Clostridia,36DYT@31979|Clostridiaceae	186801|Clostridia	L	DNA mismatch repair protein MutS	mutS4	-	-	-	-	-	-	-	-	-	-	-	MutS_III,MutS_V
DEZH2_k127_3445616_0	877420.ATVW01000001_gene2221	4.574e-162	520.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,27IHN@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
DEZH2_k127_3445616_1	1392491.JIAE01000001_gene1179	4.45e-111	381.0	COG4248@1|root,COG4248@2|Bacteria,1UYZP@1239|Firmicutes,24MHH@186801|Clostridia	186801|Clostridia	S	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
DEZH2_k127_3445616_3	1410638.JHXJ01000010_gene157	2.022e-92	307.0	COG4245@1|root,COG4245@2|Bacteria,1UYN8@1239|Firmicutes,24PQD@186801|Clostridia,3WM02@541000|Ruminococcaceae	186801|Clostridia	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
DEZH2_k127_3446142_1	1392491.JIAE01000001_gene2358	4.963e-126	415.0	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia,3WNMK@541000|Ruminococcaceae	186801|Clostridia	L	Smr domain	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
DEZH2_k127_3446142_3	699246.HMPREF0868_1132	5.791e-47	176.0	COG0558@1|root,COG0558@2|Bacteria,1V35A@1239|Firmicutes,24IIY@186801|Clostridia,269CP@186813|unclassified Clostridiales	186801|Clostridia	I	CDP-alcohol phosphatidyltransferase	pgsA2	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
DEZH2_k127_3446142_0	1392491.JIAE01000001_gene2359	1.583e-151	486.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia,3WH67@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
DEZH2_k127_3446142_2	394503.Ccel_1459	3.134e-62	227.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,36DHP@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
DEZH2_k127_3454353_4	1163671.JAGI01000003_gene897	1.484e-36	138.0	COG0347@1|root,COG0347@2|Bacteria,1VASB@1239|Firmicutes,24J84@186801|Clostridia,36JNI@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the P(II) protein family	-	-	-	ko:K02589	-	-	-	-	ko00000	-	-	-	P-II
DEZH2_k127_3454353_3	1195236.CTER_2703	1.462e-51	184.0	COG0347@1|root,COG0347@2|Bacteria,1VB4G@1239|Firmicutes,24MQ1@186801|Clostridia,3WJC7@541000|Ruminococcaceae	186801|Clostridia	K	Belongs to the P(II) protein family	-	-	-	ko:K02590	-	-	-	-	ko00000	-	-	-	P-II
DEZH2_k127_3454353_0	1163671.JAGI01000003_gene895	1.278e-264	823.0	COG2710@1|root,COG2710@2|Bacteria,1TQUW@1239|Firmicutes,248JD@186801|Clostridia,36EDP@31979|Clostridiaceae	186801|Clostridia	C	nitrogenase molybdenum-iron protein alpha chain	nifD	-	1.18.6.1	ko:K02586	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS02415	Oxidored_nitro
DEZH2_k127_3454353_1	1298920.KI911353_gene1492	1.268e-204	646.0	COG2710@1|root,COG2710@2|Bacteria,1TQ3A@1239|Firmicutes,249I5@186801|Clostridia	186801|Clostridia	C	This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation	nifK	-	1.18.6.1	ko:K02591	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
DEZH2_k127_3454353_2	1195236.CTER_2706	1.053e-83	283.0	COG2710@1|root,COG2710@2|Bacteria,1TT07@1239|Firmicutes,248NS@186801|Clostridia,3WGTM@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the NifD NifK NifE NifN family	nifE	-	-	ko:K02587	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
DEZH2_k127_3461801_0	357809.Cphy_1473	1.412e-94	322.0	COG0627@1|root,COG0627@2|Bacteria,1VJ65@1239|Firmicutes	1239|Firmicutes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
DEZH2_k127_3499837_3	537013.CLOSTMETH_02259	1.827e-10	63.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,3WHHC@541000|Ruminococcaceae	186801|Clostridia	V	ABC transporter	sagG	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DEZH2_k127_3499837_0	537013.CLOSTMETH_02260	1.551e-97	331.0	COG0842@1|root,COG0842@2|Bacteria,1TSNF@1239|Firmicutes	1239|Firmicutes	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
DEZH2_k127_3499837_1	537013.CLOSTMETH_02261	4.511e-78	275.0	COG0842@1|root,COG0842@2|Bacteria,1VBRB@1239|Firmicutes,24IMF@186801|Clostridia	186801|Clostridia	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
DEZH2_k127_3499837_2	537013.CLOSTMETH_02263	6.123e-27	119.0	COG4585@1|root,COG4585@2|Bacteria,1TSJX@1239|Firmicutes,247MV@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
DEZH2_k127_3526527_4	1392491.JIAE01000001_gene1911	4.194e-62	217.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,3WGUC@541000|Ruminococcaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
DEZH2_k127_3526527_0	699246.HMPREF0868_1452	7.934e-148	481.0	COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,2499P@186801|Clostridia,2681G@186813|unclassified Clostridiales	186801|Clostridia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
DEZH2_k127_3526527_1	1392491.JIAE01000001_gene1076	1.467e-123	413.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,249K8@186801|Clostridia,3WGY9@541000|Ruminococcaceae	186801|Clostridia	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
DEZH2_k127_3526527_2	86416.Clopa_0396	1.629e-81	282.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,36EJH@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	tsgC13	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
DEZH2_k127_3526527_3	1443125.Z962_11695	5.932e-76	264.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,36EKF@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	tsgB13	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
DEZH2_k127_3550920_1	1410638.JHXJ01000010_gene164	3.221e-126	407.0	COG0187@1|root,COG0187@2|Bacteria,1TQ6U@1239|Firmicutes,249NI@186801|Clostridia,3WN4C@541000|Ruminococcaceae	186801|Clostridia	L	TopoisomeraseII	-	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
DEZH2_k127_3550920_0	1392491.JIAE01000001_gene1173	1.466e-273	852.0	COG0188@1|root,COG0188@2|Bacteria,1TPPU@1239|Firmicutes,24CU3@186801|Clostridia,3WG8X@541000|Ruminococcaceae	186801|Clostridia	L	PFAM DNA gyrase topoisomerase IV, subunit A	-	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
DEZH2_k127_3550920_3	1392491.JIAE01000001_gene1173	1.055e-42	160.0	COG0188@1|root,COG0188@2|Bacteria,1TPPU@1239|Firmicutes,24CU3@186801|Clostridia,3WG8X@541000|Ruminococcaceae	186801|Clostridia	L	PFAM DNA gyrase topoisomerase IV, subunit A	-	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
DEZH2_k127_3550920_2	1392491.JIAE01000001_gene1174	5.587e-97	331.0	COG0726@1|root,COG0726@2|Bacteria,1TWQ0@1239|Firmicutes,24BEF@186801|Clostridia,3WI2D@541000|Ruminococcaceae	186801|Clostridia	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
DEZH2_k127_3563399_1	1410638.JHXJ01000032_gene241	1.397e-67	244.0	COG1323@1|root,COG1323@2|Bacteria,1TPP2@1239|Firmicutes,247UP@186801|Clostridia,3WI9X@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the UPF0348 family	-	-	-	-	-	-	-	-	-	-	-	-	HIGH_NTase1
DEZH2_k127_3563399_2	1158609.I586_01950	1.713e-06	60.0	COG3405@1|root,COG3405@2|Bacteria,1V4ZT@1239|Firmicutes,4HG8R@91061|Bacilli,4B1SP@81852|Enterococcaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 8 (cellulase D) family	ydaJ	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_8
DEZH2_k127_3563399_0	1121335.Clst_1242	1.124e-80	274.0	COG0280@1|root,COG0280@2|Bacteria,1TPQ0@1239|Firmicutes,247W9@186801|Clostridia,3WGX7@541000|Ruminococcaceae	186801|Clostridia	C	PFAM Phosphate acetyl butaryl transferase	pta	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
DEZH2_k127_35855_0	1280689.AUJC01000003_gene1385	1.841e-79	274.0	COG0451@1|root,COG0451@2|Bacteria,1TR3K@1239|Firmicutes,24DZK@186801|Clostridia,36GEX@31979|Clostridiaceae	186801|Clostridia	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
DEZH2_k127_35855_1	1042877.GQS_06270	7.6e-60	224.0	COG4826@1|root,arCOG04933@2157|Archaea,2XV8M@28890|Euryarchaeota,243MH@183968|Thermococci	183968|Thermococci	O	SERine  Proteinase INhibitors	-	GO:0003674,GO:0004857,GO:0004866,GO:0004867,GO:0005575,GO:0005576,GO:0005615,GO:0008150,GO:0009892,GO:0010466,GO:0010605,GO:0010951,GO:0019222,GO:0030162,GO:0030234,GO:0030414,GO:0031323,GO:0031324,GO:0032268,GO:0032269,GO:0043086,GO:0044092,GO:0044421,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0080090,GO:0098772	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
DEZH2_k127_3585719_3	1094980.Mpsy_3170	1.434e-05	48.0	COG1520@1|root,arCOG06836@1|root,arCOG02482@2157|Archaea,arCOG06836@2157|Archaea,2Y2W0@28890|Euryarchaeota,2NADE@224756|Methanomicrobia	224756|Methanomicrobia	S	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,PKD
DEZH2_k127_3585719_0	1122915.AUGY01000054_gene74	3.033e-277	866.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,4HAAG@91061|Bacilli,26QA6@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
DEZH2_k127_3585719_1	1034347.CAHJ01000066_gene2914	2.267e-169	546.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,4HCEP@91061|Bacilli,1ZBU0@1386|Bacillus	91061|Bacilli	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	1.3.1.31	ko:K10797	ko00360,ko01120,map00360,map01120	-	R02252	RC00669	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
DEZH2_k127_3603416_0	1232453.BAIF02000109_gene2335	1.693e-116	392.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,268JT@186813|unclassified Clostridiales	186801|Clostridia	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
DEZH2_k127_3603416_1	1410638.JHXJ01000021_gene2362	5.463e-35	141.0	COG4720@1|root,COG4720@2|Bacteria,1VF2R@1239|Firmicutes,24QR3@186801|Clostridia,3WMJA@541000|Ruminococcaceae	186801|Clostridia	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
DEZH2_k127_3603693_0	626939.HMPREF9443_01364	2.716e-69	240.0	COG1373@1|root,COG1373@2|Bacteria,1TP7X@1239|Firmicutes,4H3BY@909932|Negativicutes	909932|Negativicutes	S	Psort location Cytoplasmic, score	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
DEZH2_k127_3603693_1	883109.HMPREF0380_00146	5.643e-65	231.0	COG0484@1|root,COG0484@2|Bacteria,1V5G5@1239|Firmicutes,24JFC@186801|Clostridia	186801|Clostridia	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3603693_3	888727.HMPREF9092_1642	2.871e-45	167.0	2BPEU@1|root,32I71@2|Bacteria,1VDVA@1239|Firmicutes,25BDW@186801|Clostridia	186801|Clostridia	S	HIRAN	-	-	-	-	-	-	-	-	-	-	-	-	HIRAN
DEZH2_k127_3603693_2	1410653.JHVC01000006_gene150	6.276e-54	197.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,36DXW@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_3618619_2	1121335.Clst_2072	4.052e-102	336.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,3WGJQ@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
DEZH2_k127_3618619_4	1120746.CCNL01000017_gene2680	6.826e-13	80.0	COG1686@1|root,COG1686@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
DEZH2_k127_3618619_3	1392491.JIAE01000001_gene1071	6.749e-50	192.0	COG0337@1|root,COG0337@2|Bacteria	2|Bacteria	E	3-dehydroquinate synthase activity	aroB	-	2.7.1.71,4.2.3.152,4.2.3.4	ko:K01735,ko:K13829,ko:K19969	ko00400,ko00525,ko01100,ko01110,ko01130,ko01230,map00400,map00525,map01100,map01110,map01130,map01230	M00022,M00814,M00815	R02412,R03083,R10937	RC00002,RC00078,RC00847,RC03308	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
DEZH2_k127_3618619_0	1392491.JIAE01000001_gene1072	4.912e-119	395.0	COG2234@1|root,COG2234@2|Bacteria,1UVEY@1239|Firmicutes,2588N@186801|Clostridia,3WMA7@541000|Ruminococcaceae	186801|Clostridia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
DEZH2_k127_3618619_5	1236514.BAKL01000005_gene643	4.667e-05	52.0	COG3533@1|root,COG3533@2|Bacteria,4NG7T@976|Bacteroidetes,2FPXE@200643|Bacteroidia,4APDY@815|Bacteroidaceae	976|Bacteroidetes	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_127
DEZH2_k127_3618619_1	1235799.C818_00832	2.182e-109	368.0	COG2942@1|root,COG2942@2|Bacteria,1TQMG@1239|Firmicutes,24C1F@186801|Clostridia,27JKD@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man)	-	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
DEZH2_k127_3627093_0	641491.DND132_2166	2.287e-38	149.0	COG1167@1|root,COG1167@2|Bacteria,1MUJE@1224|Proteobacteria,42M1Z@68525|delta/epsilon subdivisions,2WJYC@28221|Deltaproteobacteria,2M7YP@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
DEZH2_k127_3627513_4	1410638.JHXJ01000017_gene582	1.481e-73	253.0	COG0131@1|root,COG0131@2|Bacteria,1TRH7@1239|Firmicutes,247WC@186801|Clostridia,3WH5P@541000|Ruminococcaceae	186801|Clostridia	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
DEZH2_k127_3627513_1	1453501.JELR01000002_gene507	4.865e-123	404.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,464SK@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DEZH2_k127_3627513_0	1392491.JIAE01000001_gene2521	1.554e-191	606.0	COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia,3WGCJ@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
DEZH2_k127_3627513_3	1392491.JIAE01000001_gene2522	2.353e-101	334.0	COG0040@1|root,COG0040@2|Bacteria,1TSVZ@1239|Firmicutes,249AR@186801|Clostridia,3WH70@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
DEZH2_k127_3627513_2	1392491.JIAE01000001_gene2523	6.902e-120	397.0	COG3705@1|root,COG3705@2|Bacteria,1TPZZ@1239|Firmicutes,248CB@186801|Clostridia,3WGQF@541000|Ruminococcaceae	186801|Clostridia	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
DEZH2_k127_3702475_4	720554.Clocl_1329	2.463e-147	476.0	COG0438@1|root,COG0438@2|Bacteria,1TQRQ@1239|Firmicutes,249H2@186801|Clostridia,3WGGV@541000|Ruminococcaceae	186801|Clostridia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DEZH2_k127_3702475_7	1121324.CLIT_10c01790	1.054e-80	275.0	COG2041@1|root,COG2041@2|Bacteria,1UZMG@1239|Firmicutes,25DEZ@186801|Clostridia	186801|Clostridia	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
DEZH2_k127_3702475_9	1511.CLOST_1063	1.046e-18	91.0	COG4892@1|root,COG4892@2|Bacteria,1VEGK@1239|Firmicutes,24QJ4@186801|Clostridia	186801|Clostridia	G	PFAM cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cyt-b5
DEZH2_k127_3702475_5	1392491.JIAE01000001_gene1979	1.549e-145	472.0	COG0524@1|root,COG0524@2|Bacteria,1TRRY@1239|Firmicutes,248Y3@186801|Clostridia,3WHKM@541000|Ruminococcaceae	186801|Clostridia	G	Kinase, PfkB family	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
DEZH2_k127_3702475_8	1235797.C816_04135	7.706e-75	260.0	COG0800@1|root,COG0800@2|Bacteria,1TS0F@1239|Firmicutes,248GA@186801|Clostridia,2N7I8@216572|Oscillospiraceae	186801|Clostridia	G	KDPG and KHG aldolase	eda	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
DEZH2_k127_3702475_3	1449050.JNLE01000003_gene3293	4.656e-173	555.0	COG1904@1|root,COG1904@2|Bacteria,1TRI0@1239|Firmicutes,248C0@186801|Clostridia,36DFN@31979|Clostridiaceae	186801|Clostridia	G	glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
DEZH2_k127_3702475_0	1033734.CAET01000065_gene2175	0.0	1215.0	COG3250@1|root,COG3250@2|Bacteria,1TPK7@1239|Firmicutes,4HBHM@91061|Bacilli,1ZPWQ@1386|Bacillus	91061|Bacilli	G	Domain of unknown function (DUF4982)	bgaA	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Big_4,DUF4982,G5,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Gram_pos_anchor,YSIRK_signal
DEZH2_k127_3702475_1	1196322.A370_03656	1.739e-251	807.0	2DB7A@1|root,2Z7KK@2|Bacteria,1TQ2C@1239|Firmicutes,24AMJ@186801|Clostridia,36H0P@31979|Clostridiaceae	186801|Clostridia	S	Glycosyl hydrolase family 115	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_115
DEZH2_k127_3702475_2	357809.Cphy_2654	5.537e-246	771.0	COG1653@1|root,COG1653@2|Bacteria,1TP6Z@1239|Firmicutes,249KG@186801|Clostridia	186801|Clostridia	G	PFAM Bacterial extracellular solute-binding	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1,SBP_bac_8
DEZH2_k127_3702475_6	357809.Cphy_2655	2.318e-99	328.0	COG0395@1|root,COG0395@2|Bacteria,1TQ9F@1239|Firmicutes,25C58@186801|Clostridia	186801|Clostridia	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
DEZH2_k127_3706451_0	1506994.JNLQ01000002_gene3222	9.706e-124	407.0	COG4213@1|root,COG4213@2|Bacteria,1TR3Q@1239|Firmicutes,2482X@186801|Clostridia,4BWQX@830|Butyrivibrio	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
DEZH2_k127_3706451_1	1392491.JIAE01000001_gene252	7.34e-66	228.0	COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,24HVV@186801|Clostridia,3WIDH@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
DEZH2_k127_3706451_2	1220534.B655_2115	0.0002544	44.0	COG0591@1|root,arCOG01316@2157|Archaea,2XU91@28890|Euryarchaeota,23NRA@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
DEZH2_k127_3720665_1	1139996.OMQ_01213	0.0003696	50.0	2DBF3@1|root,2Z8WF@2|Bacteria,1V133@1239|Firmicutes,4HGRP@91061|Bacilli	91061|Bacilli	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
DEZH2_k127_3720665_0	1514668.JOOA01000002_gene2042	1.452e-32	131.0	COG2378@1|root,COG2378@2|Bacteria,1TSA2@1239|Firmicutes,247S2@186801|Clostridia,3WH18@541000|Ruminococcaceae	186801|Clostridia	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	WYL
DEZH2_k127_3773263_5	649349.Lbys_3611	4.563e-08	59.0	COG0636@1|root,COG0636@2|Bacteria,4NURW@976|Bacteroidetes,47S5V@768503|Cytophagia	976|Bacteroidetes	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
DEZH2_k127_3773263_2	1392491.JIAE01000001_gene1582	7.654e-81	277.0	COG0356@1|root,COG0356@2|Bacteria,1TQIT@1239|Firmicutes,24A6Q@186801|Clostridia,3WIAV@541000|Ruminococcaceae	186801|Clostridia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
DEZH2_k127_3773263_1	699246.HMPREF0868_0709	5.77e-110	358.0	COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,248FV@186801|Clostridia,2689H@186813|unclassified Clostridiales	186801|Clostridia	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
DEZH2_k127_3773263_4	1410638.JHXJ01000007_gene1054	7.399e-46	169.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,3WJA1@541000|Ruminococcaceae	186801|Clostridia	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
DEZH2_k127_3773263_0	1291050.JAGE01000001_gene855	2.73e-176	561.0	COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,248NX@186801|Clostridia,3WH60@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
DEZH2_k127_3773263_3	1392491.JIAE01000001_gene1586	3.982e-49	179.0	COG0116@1|root,COG0116@2|Bacteria,1TP0X@1239|Firmicutes,248MA@186801|Clostridia,3WGN5@541000|Ruminococcaceae	186801|Clostridia	L	Belongs to the methyltransferase superfamily	ypsC	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
DEZH2_k127_3781011_1	309803.CTN_1283	3.392e-30	122.0	COG1453@1|root,COG1453@2|Bacteria,2GE5P@200918|Thermotogae	200918|Thermotogae	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
DEZH2_k127_3781011_0	1410638.JHXJ01000015_gene2449	1.134e-72	259.0	COG1996@1|root,COG1996@2|Bacteria,1UI9I@1239|Firmicutes,248XK@186801|Clostridia,3WHNV@541000|Ruminococcaceae	186801|Clostridia	K	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3849291_0	269797.Mbar_A1995	7.566e-97	332.0	arCOG02516@1|root,arCOG02538@1|root,arCOG02516@2157|Archaea,arCOG02538@2157|Archaea,2Y7RK@28890|Euryarchaeota,2NBKX@224756|Methanomicrobia	2157|Archaea	S	Leucine rich repeats (6 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,He_PIG,PKD,PQQ_3,Peptidase_S8,S-layer
DEZH2_k127_3849291_1	525379.HMPREF0819_0773	3.485e-22	100.0	COG4405@1|root,COG4405@2|Bacteria,1V6S0@1239|Firmicutes	1239|Firmicutes	P	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	ASCH
DEZH2_k127_3849291_4	1320556.AVBP01000019_gene1266	0.0008007	44.0	2AA5M@1|root,30ZEM@2|Bacteria,1PMCU@1224|Proteobacteria,2UZZS@28211|Alphaproteobacteria,43QQS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3849291_2	1120746.CCNL01000017_gene2523	3.573e-22	98.0	COG4895@1|root,COG4895@2|Bacteria,2NRUA@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized conserved protein (DUF2196)	ywbE	-	-	-	-	-	-	-	-	-	-	-	DUF2196
DEZH2_k127_3870142_2	1410630.JNKP01000004_gene442	2.823e-54	194.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,27M7K@186928|unclassified Lachnospiraceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_3870142_0	877411.JMMA01000002_gene1963	8.462e-167	554.0	COG0577@1|root,COG0577@2|Bacteria,1TRE5@1239|Firmicutes,24CGY@186801|Clostridia,3WGXH@541000|Ruminococcaceae	186801|Clostridia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
DEZH2_k127_3870142_1	1392491.JIAE01000001_gene293	2.84e-142	475.0	COG3590@1|root,COG3590@2|Bacteria,1TQTA@1239|Firmicutes,2482M@186801|Clostridia,3WIC3@541000|Ruminococcaceae	186801|Clostridia	O	Peptidase family M13	pepO1	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
DEZH2_k127_3870646_0	411462.DORLON_02391	2.42e-64	239.0	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,27UQN@189330|Dorea	186801|Clostridia	L	ATP-dependent helicase nuclease subunit A	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
DEZH2_k127_3876687_3	1120998.AUFC01000005_gene608	2.192e-26	109.0	COG0288@1|root,COG0288@2|Bacteria,1V1EC@1239|Firmicutes,2495A@186801|Clostridia	186801|Clostridia	P	Reversible hydration of carbon dioxide	cah	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
DEZH2_k127_3876687_2	467705.SGO_0958	5.414e-44	166.0	COG1670@1|root,COG1670@2|Bacteria,1VBDT@1239|Firmicutes,4HQ5G@91061|Bacilli	91061|Bacilli	J	Acetyltransferase (GNAT) domain	XK27_04435	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
DEZH2_k127_3876687_1	649639.Bcell_0815	2.258e-54	198.0	COG1309@1|root,COG1309@2|Bacteria,1TSUJ@1239|Firmicutes,4HJER@91061|Bacilli,1ZRHP@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator C-terminal region	XK27_03525	-	-	-	-	-	-	-	-	-	-	-	TetR_C_8,TetR_N
DEZH2_k127_3876687_0	484770.UFO1_1182	2.874e-72	250.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,4H387@909932|Negativicutes	909932|Negativicutes	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_3876687_4	760192.Halhy_3763	1.341e-16	90.0	COG0577@1|root,COG0577@2|Bacteria,4P3C0@976|Bacteroidetes	976|Bacteroidetes	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
DEZH2_k127_3891833_0	767817.Desgi_2327	3.063e-308	949.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,262AS@186807|Peptococcaceae	186801|Clostridia	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	lcfB	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
DEZH2_k127_3891833_1	509191.AEDB02000099_gene4039	2.11e-167	532.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,3WGD9@541000|Ruminococcaceae	186801|Clostridia	L	Belongs to the DEAD box helicase family	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
DEZH2_k127_3892511_0	1120746.CCNL01000005_gene108	1.004e-116	383.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2NPG9@2323|unclassified Bacteria	2|Bacteria	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	cdr	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
DEZH2_k127_3892511_1	1236976.JCM16418_1717	3.004e-70	246.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1V0B7@1239|Firmicutes,4HCI0@91061|Bacilli,26W19@186822|Paenibacillaceae	91061|Bacilli	K	helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
DEZH2_k127_3904302_2	931276.Cspa_c44330	1.111e-73	250.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,36DYK@31979|Clostridiaceae	186801|Clostridia	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
DEZH2_k127_3904302_5	755731.Clo1100_0777	3.707e-14	78.0	2C033@1|root,337RJ@2|Bacteria,1VMRZ@1239|Firmicutes,24QDC@186801|Clostridia,36M5X@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3904302_0	509191.AEDB02000064_gene551	0.0	1059.0	COG0004@1|root,COG0347@1|root,COG0004@2|Bacteria,COG0347@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,3WH0N@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the P(II) protein family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
DEZH2_k127_3904302_6	394503.Ccel_2607	9.691e-11	72.0	2EDJ2@1|root,337EY@2|Bacteria,1VERQ@1239|Firmicutes,24RYS@186801|Clostridia,36W3X@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3904302_1	1291050.JAGE01000001_gene2289	3.229e-97	325.0	COG1131@1|root,COG1131@2|Bacteria,1TS5Y@1239|Firmicutes,24AH1@186801|Clostridia,3WJJC@541000|Ruminococcaceae	186801|Clostridia	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_3904302_4	1235798.C817_04402	4.504e-44	164.0	COG1725@1|root,COG1725@2|Bacteria,1VAC6@1239|Firmicutes,24MVE@186801|Clostridia	186801|Clostridia	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	-	-	-	-	-	-	-	-	-	GntR
DEZH2_k127_3904302_3	877418.ATWV01000010_gene153	1.362e-62	224.0	COG0507@1|root,COG0507@2|Bacteria	2|Bacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	-	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
DEZH2_k127_3926550_1	398512.JQKC01000002_gene1910	6.912e-149	481.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,3WH1A@541000|Ruminococcaceae	186801|Clostridia	G	Pyruvate kinase	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
DEZH2_k127_3926550_0	1392491.JIAE01000001_gene2087	0.0	1309.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,3WH0P@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
DEZH2_k127_3930937_3	1437448.AZRT01000048_gene10	0.0006524	42.0	COG0668@1|root,COG0668@2|Bacteria,1MVX9@1224|Proteobacteria,2TTEB@28211|Alphaproteobacteria,1J1M3@118882|Brucellaceae	28211|Alphaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K16053	-	-	-	-	ko00000,ko02000	1.A.23.4.5	-	-	MS_channel
DEZH2_k127_3930937_1	1410638.JHXJ01000027_gene1164	7.872e-71	243.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,3WIX7@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
DEZH2_k127_3930937_0	1392491.JIAE01000001_gene685	5.79e-104	346.0	COG1102@1|root,COG1102@2|Bacteria,1U904@1239|Firmicutes	1239|Firmicutes	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
DEZH2_k127_3930937_2	742723.HMPREF9477_00367	6.078e-20	102.0	2EC0M@1|root,335ZW@2|Bacteria,1VHEH@1239|Firmicutes,24F4W@186801|Clostridia,27MEY@186928|unclassified Lachnospiraceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3932104_1	748727.CLJU_c03970	1.078e-68	245.0	COG0720@1|root,COG5617@1|root,COG0720@2|Bacteria,COG5617@2|Bacteria,1UXXS@1239|Firmicutes,249CZ@186801|Clostridia,36G7U@31979|Clostridiaceae	186801|Clostridia	H	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	PTPS,PTPS_related
DEZH2_k127_3932104_3	1400520.LFAB_05795	7.003e-15	83.0	2BCCC@1|root,325XR@2|Bacteria,1UFIP@1239|Firmicutes,4IESV@91061|Bacilli,3F3X6@33958|Lactobacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_3932104_2	1423806.JCM15457_2504	2.329e-35	142.0	290YK@1|root,2ZNKB@2|Bacteria,1V5MF@1239|Firmicutes,4HX21@91061|Bacilli,3F5RH@33958|Lactobacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
DEZH2_k127_3932104_0	272562.CA_C2589	1.193e-179	573.0	COG1215@1|root,COG1215@2|Bacteria,1TR2P@1239|Firmicutes,248SW@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Glyco_tranf_2_3,Glycos_transf_2,Polysacc_deac_1
DEZH2_k127_3946922_0	1235797.C816_00106	2.775e-153	496.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,2N6YA@216572|Oscillospiraceae	186801|Clostridia	E	Thermophilic metalloprotease (M29)	pepS	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
DEZH2_k127_3946922_1	768706.Desor_3179	5.529e-148	501.0	COG5492@1|root,COG5492@2|Bacteria,1TS8J@1239|Firmicutes,24A7I@186801|Clostridia,262NZ@186807|Peptococcaceae	186801|Clostridia	N	Leucine rich repeats (6 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,LRR_5
DEZH2_k127_3946922_2	1121333.JMLH01000061_gene1415	5.565e-108	383.0	COG1876@1|root,COG1876@2|Bacteria,1TQQ3@1239|Firmicutes	1239|Firmicutes	M	Clostridial hydrophobic, with a conserved W residue, domain.	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,ChW,Esterase,Glucosaminidase,Glyco_hydro_25,Peptidase_C39_2
DEZH2_k127_3970779_1	877418.ATWV01000010_gene153	1.067e-63	228.0	COG0507@1|root,COG0507@2|Bacteria	2|Bacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	-	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
DEZH2_k127_3970779_0	1121335.Clst_1955	8.509e-167	528.0	COG4868@1|root,COG4868@2|Bacteria,1TQYE@1239|Firmicutes,247YI@186801|Clostridia,3WHJQ@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF1846
DEZH2_k127_3976511_1	755731.Clo1100_3403	9.35e-68	236.0	COG0446@1|root,COG0446@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36EYM@31979|Clostridiaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Pyr_redox_dim,Rhodanese
DEZH2_k127_3976511_2	1120746.CCNL01000010_gene1176	9.686e-68	241.0	COG0226@1|root,COG0226@2|Bacteria	2|Bacteria	P	phosphate ion binding	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like,PBP_like_2
DEZH2_k127_3976511_0	1345695.CLSA_c21510	1.543e-81	277.0	COG4832@1|root,COG4832@2|Bacteria,1TQC2@1239|Firmicutes,248YH@186801|Clostridia,36F6U@31979|Clostridiaceae	186801|Clostridia	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,TfoX_N
DEZH2_k127_3976511_3	720554.Clocl_3226	1.891e-61	218.0	COG0778@1|root,COG0778@2|Bacteria,1V3YJ@1239|Firmicutes,24BKH@186801|Clostridia,3WJMB@541000|Ruminococcaceae	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
DEZH2_k127_4010636_0	857293.CAAU_0151	1.782e-169	544.0	COG1653@1|root,COG1653@2|Bacteria,1TRPJ@1239|Firmicutes,24872@186801|Clostridia,36F95@31979|Clostridiaceae	186801|Clostridia	G	solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
DEZH2_k127_4010636_2	509191.AEDB02000081_gene2507	1.63e-133	432.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
DEZH2_k127_4010636_1	509191.AEDB02000081_gene2506	1.708e-143	462.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
DEZH2_k127_4010636_3	394503.Ccel_1008	4.559e-114	376.0	COG4573@1|root,COG4573@2|Bacteria,1TQDN@1239|Firmicutes,24A03@186801|Clostridia,36EB9@31979|Clostridiaceae	186801|Clostridia	G	Tagatose 6 phosphate kinase	-	-	-	ko:K16371	ko00052,ko01100,map00052,map01100	-	R01069	RC00438,RC00439	ko00000,ko00001	-	-	-	Tagatose_6_P_K
DEZH2_k127_4013850_3	1392491.JIAE01000001_gene2561	4.287e-139	448.0	COG3459@1|root,COG3459@2|Bacteria,1V191@1239|Firmicutes,24BR6@186801|Clostridia,3WHKW@541000|Ruminococcaceae	186801|Clostridia	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36
DEZH2_k127_4013850_1	1410638.JHXJ01000004_gene2071	1.402e-156	498.0	COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,24999@186801|Clostridia,3WGB3@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
DEZH2_k127_4013850_6	626523.GCWU000342_01661	3.791e-74	260.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia	186801|Clostridia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
DEZH2_k127_4013850_5	1410638.JHXJ01000004_gene2073	5.32e-92	311.0	COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia,3WGDD@541000|Ruminococcaceae	186801|Clostridia	S	Displays ATPase and GTPase activities	yvcJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
DEZH2_k127_4013850_8	935948.KE386494_gene502	2.316e-44	172.0	COG1481@1|root,COG1481@2|Bacteria,1TP2X@1239|Firmicutes,2484M@186801|Clostridia,42EPK@68295|Thermoanaerobacterales	186801|Clostridia	K	May be required for sporulation	whiA	-	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
DEZH2_k127_4013850_0	1392491.JIAE01000001_gene2555	2.011e-184	596.0	COG1520@1|root,COG1520@2|Bacteria,1TQ7F@1239|Firmicutes,249BV@186801|Clostridia,3WHZZ@541000|Ruminococcaceae	186801|Clostridia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2
DEZH2_k127_4013850_7	1392491.JIAE01000001_gene2553	4.175e-45	170.0	28UUX@1|root,2ZGYY@2|Bacteria,1W4NC@1239|Firmicutes,257A0@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4013850_4	1392491.JIAE01000001_gene2552	7.558e-100	336.0	COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,249IT@186801|Clostridia,3WPS4@541000|Ruminococcaceae	186801|Clostridia	F	Phosphoribulokinase / Uridine kinase family	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
DEZH2_k127_4013850_2	1392491.JIAE01000001_gene2551	9.181e-149	475.0	COG1897@1|root,COG1897@2|Bacteria,1TQVR@1239|Firmicutes,247NP@186801|Clostridia,3WGY0@541000|Ruminococcaceae	186801|Clostridia	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metAA	-	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS11970	AA_kinase,HTS
DEZH2_k127_4013850_10	1392491.JIAE01000001_gene2550	1.485e-13	76.0	COG0063@1|root,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,3WPRH@541000|Ruminococcaceae	186801|Clostridia	G	Carbohydrate kinase	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	ACPS,Carb_kinase,YjeF_N
DEZH2_k127_4032387_0	509191.AEDB02000021_gene3132	4.148e-201	638.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,3WGZR@541000|Ruminococcaceae	186801|Clostridia	G	Hydrolase Family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
DEZH2_k127_4049385_1	1469948.JPNB01000001_gene1429	2.268e-183	592.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,36EVW@31979|Clostridiaceae	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	CBM_6,Glyco_hydro_3,Glyco_hydro_3_C
DEZH2_k127_4049385_6	642492.Clole_0684	1.734e-41	167.0	COG0546@1|root,COG0572@1|root,COG0546@2|Bacteria,COG0572@2|Bacteria,1VETJ@1239|Firmicutes	1239|Firmicutes	F	Phosphoribulokinase / Uridine kinase family	-	-	2.7.1.48,3.1.3.18	ko:K00876,ko:K01091	ko00240,ko00630,ko00983,ko01100,ko01110,ko01130,map00240,map00630,map00983,map01100,map01110,map01130	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01334,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
DEZH2_k127_4049385_4	293826.Amet_2172	1.572e-95	324.0	COG2199@1|root,COG3829@1|root,COG3706@2|Bacteria,COG3829@2|Bacteria,1VB8N@1239|Firmicutes,25EJ3@186801|Clostridia	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
DEZH2_k127_4049385_7	158190.SpiGrapes_0278	2.716e-16	81.0	COG4877@1|root,COG4877@2|Bacteria,2J8S8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4049385_3	350688.Clos_0564	4.126e-123	404.0	COG0330@1|root,COG0330@2|Bacteria,1TRN5@1239|Firmicutes,248UU@186801|Clostridia,36F5D@31979|Clostridiaceae	186801|Clostridia	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
DEZH2_k127_4049385_2	1195236.CTER_0833	1.756e-137	462.0	COG1368@1|root,COG1368@2|Bacteria,1TRMA@1239|Firmicutes	1239|Firmicutes	M	Belongs to the LTA synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
DEZH2_k127_4049385_0	1195236.CTER_0502	0.0	1211.0	COG1328@1|root,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,3WGUQ@541000|Ruminococcaceae	186801|Clostridia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Glutaredoxin,NRDD
DEZH2_k127_4049385_5	1195236.CTER_0503	2.869e-85	287.0	COG1180@1|root,COG1180@2|Bacteria,1V1GP@1239|Firmicutes,24G76@186801|Clostridia,3WIQV@541000|Ruminococcaceae	186801|Clostridia	O	TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
DEZH2_k127_4049385_8	931276.Cspa_c23720	4.646e-12	68.0	2BCQM@1|root,326B1@2|Bacteria,1W0K9@1239|Firmicutes,24W3A@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4061347_0	1476973.JMMB01000007_gene1865	2.576e-254	796.0	COG0488@1|root,COG0488@2|Bacteria,1TSB8@1239|Firmicutes,248XT@186801|Clostridia,25QK3@186804|Peptostreptococcaceae	186801|Clostridia	S	ATPases associated with a variety of cellular activities	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
DEZH2_k127_4061347_2	1286171.EAL2_c05520	2.748e-31	124.0	2C858@1|root,33359@2|Bacteria,1VAC1@1239|Firmicutes,24RYB@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF1413)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1413
DEZH2_k127_4061347_1	767817.Desgi_3532	1.274e-166	546.0	COG2199@1|root,COG2200@1|root,COG2202@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG2202@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia,267EP@186807|Peptococcaceae	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_9,Peripla_BP_3
DEZH2_k127_407117_2	1392491.JIAE01000001_gene2322	4.501e-70	244.0	COG0566@1|root,COG0566@2|Bacteria,1TS18@1239|Firmicutes,24KJT@186801|Clostridia,3WPK8@541000|Ruminococcaceae	186801|Clostridia	J	SpoU rRNA Methylase family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
DEZH2_k127_407117_0	37659.JNLN01000001_gene809	1.409e-101	348.0	COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,36DJD@31979|Clostridiaceae	186801|Clostridia	V	MATE efflux family protein	mepA1	-	-	-	-	-	-	-	-	-	-	-	MatE
DEZH2_k127_407117_4	428125.CLOLEP_02941	5.405e-11	67.0	COG4818@1|root,COG4818@2|Bacteria,1VG59@1239|Firmicutes,24VR1@186801|Clostridia,3WMMQ@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_407117_5	1158602.I590_01275	1.856e-07	60.0	COG0425@1|root,COG0425@2|Bacteria,1V6BY@1239|Firmicutes,4HIQD@91061|Bacilli,4B1TM@81852|Enterococcaceae	91061|Bacilli	O	Belongs to the sulfur carrier protein TusA family	yedF	-	-	-	-	-	-	-	-	-	-	-	DrsE,TusA
DEZH2_k127_407117_1	1392491.JIAE01000001_gene597	6.399e-74	257.0	28P0Q@1|root,2ZBX8@2|Bacteria,1V22P@1239|Firmicutes,248XV@186801|Clostridia,3WJK7@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_407117_3	1410638.JHXJ01000039_gene985	1.23e-60	213.0	COG0563@1|root,COG1302@1|root,COG0563@2|Bacteria,COG1302@2|Bacteria,1V1TU@1239|Firmicutes,24E60@186801|Clostridia,3WJ2N@541000|Ruminococcaceae	186801|Clostridia	F	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Asp23,IPT
DEZH2_k127_4072751_4	1122915.AUGY01000009_gene4927	2.695e-21	93.0	COG4154@1|root,COG4154@2|Bacteria,1V402@1239|Firmicutes,4HJRX@91061|Bacilli,26XPH@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the RbsD FucU family	fucU	-	5.1.3.29	ko:K02431	-	-	R10764	RC00563	ko00000,ko01000	-	-	-	RbsD_FucU
DEZH2_k127_4072751_2	1226325.HMPREF1548_02771	8.862e-161	512.0	COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,248FK@186801|Clostridia,36DI6@31979|Clostridiaceae	186801|Clostridia	K	aldo keto reductase	-	-	1.1.1.2	ko:K00002	ko00010,ko00040,ko00561,ko00930,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00561,map00930,map01100,map01110,map01120,map01130,map01220	M00014	R00746,R01041,R01481,R05231	RC00087,RC00088,RC00099,RC00108	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Aldo_ket_red
DEZH2_k127_4072751_1	428125.CLOLEP_00012	1.486e-188	594.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,3WJ40@541000|Ruminococcaceae	186801|Clostridia	C	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
DEZH2_k127_4072751_0	1235799.C818_00888	9.234e-216	679.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,27IKI@186928|unclassified Lachnospiraceae	186801|Clostridia	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
DEZH2_k127_4072751_3	1235792.C808_04706	5.484e-72	248.0	COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,248WR@186801|Clostridia,27IP8@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Glycosyl hydrolases family 31	-	-	-	-	-	-	-	-	-	-	-	-	DUF4968,DUF5110,Glyco_hydro_31
DEZH2_k127_4098832_1	1304875.JAFZ01000001_gene1947	3.035e-39	148.0	COG0640@1|root,COG0640@2|Bacteria,3TBVR@508458|Synergistetes	508458|Synergistetes	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
DEZH2_k127_4098832_2	1121423.JONT01000016_gene1144	8.527e-36	138.0	COG2846@1|root,COG2846@2|Bacteria,1V6WD@1239|Firmicutes,24RHC@186801|Clostridia	186801|Clostridia	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	-
DEZH2_k127_4098832_0	1121105.ATXL01000010_gene914	4.869e-267	829.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,4H9SP@91061|Bacilli,4B0D4@81852|Enterococcaceae	91061|Bacilli	P	E1-E2 ATPase	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
DEZH2_k127_4166671_2	1235835.C814_00048	7.587e-150	477.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,3WG8C@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
DEZH2_k127_4166671_0	1120746.CCNL01000017_gene2684	4.132e-288	893.0	COG1155@1|root,COG1155@2|Bacteria,2NNYK@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
DEZH2_k127_4166671_5	1392493.JIAB01000001_gene2486	1.434e-30	123.0	COG1436@1|root,COG1436@2|Bacteria,1VAX7@1239|Firmicutes,24MXC@186801|Clostridia,27PA3@186928|unclassified Lachnospiraceae	186801|Clostridia	C	ATP synthase (F/14-kDa) subunit	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
DEZH2_k127_4166671_3	411470.RUMGNA_02761	2.158e-70	249.0	COG1527@1|root,COG1527@2|Bacteria,1U6WZ@1239|Firmicutes,249XD@186801|Clostridia,3XYWC@572511|Blautia	186801|Clostridia	C	Psort location Cytoplasmic, score 8.87	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
DEZH2_k127_4166671_6	457421.CBFG_04897	3.963e-20	97.0	COG1390@1|root,COG1390@2|Bacteria,1VDHZ@1239|Firmicutes,24H5N@186801|Clostridia	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
DEZH2_k127_4166671_4	693746.OBV_22580	1.967e-36	143.0	COG0636@1|root,COG0636@2|Bacteria,1V786@1239|Firmicutes,24HBF@186801|Clostridia,2N76H@216572|Oscillospiraceae	186801|Clostridia	C	ATP synthase subunit C	ntpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
DEZH2_k127_4166671_1	445972.ANACOL_00852	4.282e-157	519.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,3WHFQ@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the V-ATPase 116 kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
DEZH2_k127_4185291_3	1265845.PWEIH_15933	1.263e-100	342.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,4HA41@91061|Bacilli,26JPN@186820|Listeriaceae	91061|Bacilli	M	1,2-diacylglycerol 3-glucosyltransferase	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
DEZH2_k127_4185291_9	1347369.CCAD010000065_gene3850	7.855e-13	78.0	COG3595@1|root,COG3595@2|Bacteria,1V94C@1239|Firmicutes,4HJYP@91061|Bacilli,1ZEE4@1386|Bacillus	91061|Bacilli	S	Putative adhesin	liaG	-	-	ko:K11621	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	DUF4097
DEZH2_k127_4185291_6	1294142.CINTURNW_3996	1.99e-45	172.0	2AKUT@1|root,31BMY@2|Bacteria,1V967@1239|Firmicutes,24DHX@186801|Clostridia,36HU3@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4185291_7	1121342.AUCO01000015_gene2709	2.265e-45	166.0	COG1695@1|root,COG1695@2|Bacteria,1VA94@1239|Firmicutes,24N33@186801|Clostridia,36JKC@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
DEZH2_k127_4185291_8	619693.HMPREF6745_1481	1.87e-13	79.0	2B09D@1|root,31SK9@2|Bacteria,4NS49@976|Bacteroidetes	976|Bacteroidetes	S	Putative zincin peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3267
DEZH2_k127_4185291_5	1410638.JHXJ01000019_gene469	1.273e-69	246.0	COG0679@1|root,COG0679@2|Bacteria,1UY4N@1239|Firmicutes,24ACC@186801|Clostridia,3WI1Q@541000|Ruminococcaceae	186801|Clostridia	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
DEZH2_k127_4185291_1	1226322.HMPREF1545_02676	3.618e-190	606.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,2N6TX@216572|Oscillospiraceae	186801|Clostridia	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
DEZH2_k127_4185291_2	887929.HMP0721_0662	9.889e-145	474.0	COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,25UZT@186806|Eubacteriaceae	186801|Clostridia	G	Psort location Cytoplasmic, score	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
DEZH2_k127_4185291_4	1042376.AFPK01000068_gene451	1.325e-92	316.0	COG1432@1|root,COG1432@2|Bacteria,4NGF1@976|Bacteroidetes,1HWKN@117743|Flavobacteriia,406NS@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
DEZH2_k127_4185291_0	1392491.JIAE01000001_gene2299	2.02e-222	696.0	COG4108@1|root,COG4108@2|Bacteria,1TPYT@1239|Firmicutes,247X3@186801|Clostridia,3WGUR@541000|Ruminococcaceae	186801|Clostridia	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
DEZH2_k127_4193710_1	1280692.AUJL01000002_gene2744	1.839e-12	70.0	28IHZ@1|root,2Z8J5@2|Bacteria,1TQV6@1239|Firmicutes,249TE@186801|Clostridia,36HG5@31979|Clostridiaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4193710_0	720554.Clocl_2838	2.956e-261	818.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,3WGEX@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
DEZH2_k127_4201960_2	1031288.AXAA01000004_gene1811	7.036e-46	171.0	COG0613@1|root,COG0613@2|Bacteria,1V3ZK@1239|Firmicutes,24HHA@186801|Clostridia,36J80@31979|Clostridiaceae	186801|Clostridia	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
DEZH2_k127_4201960_5	1120746.CCNL01000017_gene2978	2.45e-19	91.0	COG0857@1|root,COG0857@2|Bacteria,2NRZD@2323|unclassified Bacteria	2|Bacteria	C	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
DEZH2_k127_4201960_1	1304284.L21TH_2147	4.922e-99	338.0	COG2000@1|root,COG2221@1|root,COG4624@1|root,COG2000@2|Bacteria,COG2221@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,24BF5@186801|Clostridia,36E2Y@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,Fer4_9
DEZH2_k127_4201960_3	1121335.Clst_0605	6.528e-44	165.0	COG2172@1|root,COG2172@2|Bacteria,1V6YP@1239|Firmicutes,24JJ0@186801|Clostridia,3WJNT@541000|Ruminococcaceae	186801|Clostridia	T	Anti-sigma regulatory factor (Ser Thr protein kinase)	RsbW	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2
DEZH2_k127_4201960_4	1121335.Clst_0604	1.972e-36	141.0	COG4109@1|root,COG4109@2|Bacteria,1VA3T@1239|Firmicutes,24MQM@186801|Clostridia,3WJAV@541000|Ruminococcaceae	186801|Clostridia	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
DEZH2_k127_4201960_0	1392491.JIAE01000001_gene1424	5.925e-177	561.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia	186801|Clostridia	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
DEZH2_k127_4201960_6	1161902.HMPREF0378_1286	9.533e-11	63.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,3WDCS@538999|Clostridiales incertae sedis	186801|Clostridia	E	Glutamine synthetase, catalytic domain	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
DEZH2_k127_4203297_1	1392491.JIAE01000001_gene1577	3.976e-246	765.0	COG0055@1|root,COG0055@2|Bacteria,1UZMA@1239|Firmicutes,24FGN@186801|Clostridia,3WREE@541000|Ruminococcaceae	186801|Clostridia	C	ATP synthase alpha/beta family, beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_ab,ATP-synt_ab_N
DEZH2_k127_4203297_2	1392491.JIAE01000001_gene1578	5.28e-117	385.0	COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia,3WHJU@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
DEZH2_k127_4203297_0	1392491.JIAE01000001_gene1579	1.574e-249	785.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,3WGXD@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,OSCP
DEZH2_k127_4203297_3	1408422.JHYF01000012_gene3251	1.914e-14	79.0	COG0711@1|root,COG0711@2|Bacteria,1VB85@1239|Firmicutes,24RWR@186801|Clostridia,36M51@31979|Clostridiaceae	186801|Clostridia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01170	ATP-synt_B
DEZH2_k127_4206063_2	610130.Closa_0819	6.831e-18	88.0	COG4485@1|root,COG4485@2|Bacteria,1TRR1@1239|Firmicutes,24BHM@186801|Clostridia,21XE7@1506553|Lachnoclostridium	186801|Clostridia	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	GtrA,YfhO
DEZH2_k127_4206063_0	1392491.JIAE01000001_gene2424	6.446e-208	680.0	COG4485@1|root,COG4485@2|Bacteria,1TRR1@1239|Firmicutes,24BHM@186801|Clostridia,3WHJ5@541000|Ruminococcaceae	186801|Clostridia	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	GtrA,YfhO
DEZH2_k127_4206063_1	1195236.CTER_3167	2.463e-24	108.0	COG1328@1|root,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,3WHPK@541000|Ruminococcaceae	186801|Clostridia	F	Ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
DEZH2_k127_42164_1	1392491.JIAE01000001_gene1547	6.543e-32	131.0	COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,248H7@186801|Clostridia,3WGCC@541000|Ruminococcaceae	186801|Clostridia	G	beta-galactosidase	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Laminin_G_3
DEZH2_k127_42164_0	1105031.HMPREF1141_1019	3.094e-311	968.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,36G29@31979|Clostridiaceae	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
DEZH2_k127_4217824_3	398512.JQKC01000004_gene5140	6.897e-46	173.0	COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia,3WRRF@541000|Ruminococcaceae	186801|Clostridia	P	Putative NAD(P)-binding	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
DEZH2_k127_4217824_2	394503.Ccel_2080	2.002e-109	370.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,36DPR@31979|Clostridiaceae	186801|Clostridia	P	potassium uptake protein, TrkH family	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
DEZH2_k127_4217824_0	1392491.JIAE01000001_gene1786	2.078e-319	987.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia,3WG9R@541000|Ruminococcaceae	186801|Clostridia	C	aconitate hydratase	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
DEZH2_k127_4217824_1	1410638.JHXJ01000002_gene1272	5.62e-133	429.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia,3WGKI@541000|Ruminococcaceae	186801|Clostridia	C	citrate synthase	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
DEZH2_k127_4221203_9	1392491.JIAE01000001_gene1206	1.771e-55	202.0	COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia,3WHDP@541000|Ruminococcaceae	186801|Clostridia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
DEZH2_k127_4221203_7	1410638.JHXJ01000002_gene1344	6.504e-79	273.0	COG0564@1|root,COG0564@2|Bacteria,1TS1T@1239|Firmicutes,249AH@186801|Clostridia,3WI75@541000|Ruminococcaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD_2	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
DEZH2_k127_4221203_10	203119.Cthe_0338	6.867e-54	194.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24HFB@186801|Clostridia,3WISW@541000|Ruminococcaceae	186801|Clostridia	C	NADH-quinone oxidoreductase, E subunit	nuoE	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00334,ko:K18330,ko:K22340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
DEZH2_k127_4221203_0	665956.HMPREF1032_01745	4.12e-278	866.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,3WGG2@541000|Ruminococcaceae	186801|Clostridia	C	NADH ubiquinone oxidoreductase	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
DEZH2_k127_4221203_1	935948.KE386494_gene217	3.027e-234	738.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,42FJV@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,Fer4_9,NADH-G_4Fe-4S_3
DEZH2_k127_4221203_2	1392491.JIAE01000001_gene1208	2.58e-229	720.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,3WGE5@541000|Ruminococcaceae	186801|Clostridia	D	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
DEZH2_k127_4221203_8	1209989.TepiRe1_1409	8.384e-77	267.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,24967@186801|Clostridia,42EQD@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Metallophosphoesterase	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
DEZH2_k127_4221203_11	1392491.JIAE01000001_gene1217	8.956e-32	130.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia,3WJA4@541000|Ruminococcaceae	186801|Clostridia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
DEZH2_k127_4221203_5	1392491.JIAE01000001_gene1218	9.741e-116	381.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,3WGKV@541000|Ruminococcaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
DEZH2_k127_4221203_12	1121335.Clst_0518	5.33e-20	99.0	COG3879@1|root,COG3879@2|Bacteria,1V0FG@1239|Firmicutes,24DRC@186801|Clostridia,3WJGQ@541000|Ruminococcaceae	186801|Clostridia	S	Bacterial protein of unknown function (DUF881)	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
DEZH2_k127_4221203_13	351627.Csac_0928	6.303e-16	87.0	COG3879@1|root,COG3879@2|Bacteria,1V0FG@1239|Firmicutes,24DRC@186801|Clostridia,42G46@68295|Thermoanaerobacterales	186801|Clostridia	S	Bacterial protein of unknown function (DUF881)	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
DEZH2_k127_4221203_6	1392491.JIAE01000001_gene1219	2.618e-103	345.0	COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia,3WHAN@541000|Ruminococcaceae	186801|Clostridia	T	phosphate starvation-inducible protein	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
DEZH2_k127_4221203_3	1392491.JIAE01000001_gene1220	7.923e-173	565.0	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,249W0@186801|Clostridia,3WGPZ@541000|Ruminococcaceae	186801|Clostridia	S	7TM-HD extracellular	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
DEZH2_k127_4221203_4	1392491.JIAE01000001_gene1221	2.724e-134	443.0	COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,24876@186801|Clostridia,3WGJ2@541000|Ruminococcaceae	186801|Clostridia	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
DEZH2_k127_4221203_14	1519439.JPJG01000002_gene1093	2.49e-12	72.0	COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,249TI@186801|Clostridia,2N6HY@216572|Oscillospiraceae	186801|Clostridia	L	Recombination protein O C terminal	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
DEZH2_k127_4223023_3	1105031.HMPREF1141_0922	1.59e-24	106.0	COG1820@1|root,COG1820@2|Bacteria,1TPFK@1239|Firmicutes,2481N@186801|Clostridia,36FD4@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
DEZH2_k127_4223023_2	1410632.JHWW01000009_gene2530	1.812e-72	252.0	COG0613@1|root,COG0613@2|Bacteria,1V33M@1239|Firmicutes,24H1U@186801|Clostridia,27KUN@186928|unclassified Lachnospiraceae	186801|Clostridia	S	PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP,PHP_C
DEZH2_k127_4223023_0	1123226.KB899315_gene1681	2.897e-142	465.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,4HEE7@91061|Bacilli,274FB@186822|Paenibacillaceae	91061|Bacilli	V	Multidrug transporter MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
DEZH2_k127_4223023_1	1121335.Clst_0014	2.136e-139	456.0	COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,1TQH8@1239|Firmicutes,2491Q@186801|Clostridia,3WHBY@541000|Ruminococcaceae	186801|Clostridia	S	AMMECR1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
DEZH2_k127_4223023_4	1120746.CCNL01000017_gene2581	1.316e-07	53.0	COG1180@1|root,COG1180@2|Bacteria,2NP82@2323|unclassified Bacteria	2|Bacteria	O	Radical SAM superfamily	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
DEZH2_k127_4228597_1	720554.Clocl_3396	8.366e-08	57.0	COG1022@1|root,COG1022@2|Bacteria,1TS22@1239|Firmicutes,24AZW@186801|Clostridia,3WHKE@541000|Ruminococcaceae	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
DEZH2_k127_4228597_0	1410638.JHXJ01000017_gene597	2.192e-31	135.0	2EAFW@1|root,334J8@2|Bacteria,1VH80@1239|Firmicutes,24DR1@186801|Clostridia,3WS0R@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_424234_2	1392491.JIAE01000001_gene383	6.727e-24	101.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia,3WGA7@541000|Ruminococcaceae	186801|Clostridia	J	translation elongation	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DEZH2_k127_424234_0	1410612.JNKO01000003_gene1652	2.158e-66	240.0	COG0226@1|root,COG0226@2|Bacteria,1VT8I@1239|Firmicutes,24IAW@186801|Clostridia,2PS1B@265975|Oribacterium	186801|Clostridia	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
DEZH2_k127_424234_3	411489.CLOL250_00753	0.000108	48.0	COG2340@1|root,COG5492@1|root,COG2340@2|Bacteria,COG5492@2|Bacteria,1TS8J@1239|Firmicutes,24A7I@186801|Clostridia,36HMP@31979|Clostridiaceae	186801|Clostridia	N	COG COG3291 FOG PKD repeat	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,LRR_5
DEZH2_k127_4297602_1	1321778.HMPREF1982_01468	2.213e-69	250.0	COG0842@1|root,COG0842@2|Bacteria,1UYEY@1239|Firmicutes,24BCP@186801|Clostridia	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
DEZH2_k127_4297602_0	1105031.HMPREF1141_1257	6.003e-146	470.0	COG1875@1|root,COG1875@2|Bacteria,1UHTD@1239|Firmicutes,25ED1@186801|Clostridia,36EGB@31979|Clostridiaceae	186801|Clostridia	T	PFAM PhoH family protein	-	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
DEZH2_k127_4316477_0	1444306.JFZC01000039_gene480	2.908e-34	148.0	COG0642@1|root,COG2205@2|Bacteria,1TRAB@1239|Firmicutes,4HAXE@91061|Bacilli	91061|Bacilli	T	Domain of unknown function (DUF4173)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4173
DEZH2_k127_4316477_1	411467.BACCAP_04451	7.769e-28	114.0	COG3655@1|root,COG3655@2|Bacteria,1VESP@1239|Firmicutes,24QSQ@186801|Clostridia,269GD@186813|unclassified Clostridiales	186801|Clostridia	K	Cro/C1-type HTH DNA-binding domain	-	-	-	ko:K07727	-	-	-	-	ko00000,ko03000	-	-	-	HTH_26
DEZH2_k127_4316477_2	768706.Desor_3614	1.249e-14	80.0	2BREV@1|root,32KDP@2|Bacteria,1V778@1239|Firmicutes,25AY8@186801|Clostridia,265EW@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF2975)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2975
DEZH2_k127_433476_2	537013.CLOSTMETH_01783	2.562e-115	382.0	COG0562@1|root,COG0562@2|Bacteria,1TQB9@1239|Firmicutes,249BR@186801|Clostridia,3WHCZ@541000|Ruminococcaceae	186801|Clostridia	M	UDP-galactopyranose mutase	glf	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,NAD_binding_8
DEZH2_k127_433476_5	1235802.C823_04257	2.304e-88	297.0	COG0463@1|root,COG0463@2|Bacteria,1TRRK@1239|Firmicutes,24CHM@186801|Clostridia,25ZWK@186806|Eubacteriaceae	186801|Clostridia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DEZH2_k127_433476_0	1392491.JIAE01000001_gene620	1.607e-125	417.0	COG0635@1|root,COG0635@2|Bacteria,1TREM@1239|Firmicutes,247JT@186801|Clostridia,3WGA8@541000|Ruminococcaceae	186801|Clostridia	C	Coproporphyrinogen dehydrogenase	hemZ	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DEZH2_k127_433476_7	1120746.CCNL01000014_gene2041	1.151e-55	209.0	28HHD@1|root,2Z7T3@2|Bacteria,2NQTX@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF3810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3810
DEZH2_k127_433476_8	1392491.JIAE01000001_gene618	6.938e-50	188.0	COG3503@1|root,COG3503@2|Bacteria,1V8H3@1239|Firmicutes,24JRC@186801|Clostridia,3WJIA@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
DEZH2_k127_433476_4	1410638.JHXJ01000039_gene973	1.153e-96	323.0	COG5146@1|root,COG5146@2|Bacteria,1V2R2@1239|Firmicutes,24DTK@186801|Clostridia	186801|Clostridia	H	TIGRFAM pantothenate kinase, eukaryotic staphyloccocal type	-	-	2.7.1.33	ko:K09680	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumble
DEZH2_k127_433476_9	1163671.JAGI01000002_gene1694	9.833e-15	81.0	COG1799@1|root,COG1799@2|Bacteria,1VER3@1239|Firmicutes,24I9Y@186801|Clostridia,36I3V@31979|Clostridiaceae	186801|Clostridia	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	-	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
DEZH2_k127_433476_6	1410638.JHXJ01000006_gene2513	1.769e-63	226.0	COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,3WGKD@541000|Ruminococcaceae	186801|Clostridia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	ylmE	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
DEZH2_k127_433476_3	1392491.JIAE01000001_gene1747	1.868e-99	340.0	COG0845@1|root,COG0845@2|Bacteria,1UY37@1239|Firmicutes,25Q6P@186801|Clostridia,3WHQW@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_433476_1	1392491.JIAE01000001_gene1748	6.674e-116	379.0	COG4100@1|root,COG4100@2|Bacteria,1TQ88@1239|Firmicutes,247Y4@186801|Clostridia,3WGF6@541000|Ruminococcaceae	186801|Clostridia	P	Cystathionine beta-lyase family protein involved in aluminum resistance	ynbB	-	-	-	-	-	-	-	-	-	-	-	Met_gamma_lyase
DEZH2_k127_4350497_8	411902.CLOBOL_00100	8.713e-19	87.0	COG1704@1|root,COG1704@2|Bacteria,1V3Z0@1239|Firmicutes,24IH4@186801|Clostridia,21YJD@1506553|Lachnoclostridium	186801|Clostridia	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
DEZH2_k127_4350497_5	471855.Shel_05250	1.337e-46	171.0	2DH26@1|root,2ZY4Z@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
DEZH2_k127_4350497_4	1506583.JQJY01000003_gene3567	2.342e-58	213.0	COG0388@1|root,COG0388@2|Bacteria,4NEHF@976|Bacteroidetes,1I1KU@117743|Flavobacteriia,2NVJ3@237|Flavobacterium	976|Bacteroidetes	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
DEZH2_k127_4350497_2	398512.JQKC01000014_gene1628	1.094e-77	270.0	COG0596@1|root,COG0596@2|Bacteria,1U3PB@1239|Firmicutes,24DR6@186801|Clostridia,3WJ6G@541000|Ruminococcaceae	186801|Clostridia	S	Hydrolase, alpha beta domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
DEZH2_k127_4350497_6	641146.HMPREF9020_01508	3.572e-32	130.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
DEZH2_k127_4350497_3	888055.HMPREF9015_01793	3.036e-61	215.0	COG3467@1|root,COG3467@2|Bacteria,379VD@32066|Fusobacteria	32066|Fusobacteria	S	Psort location Cytoplasmic, score 8.96	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
DEZH2_k127_4350497_1	1405.DJ92_174	4.906e-99	329.0	COG1262@1|root,COG1262@2|Bacteria,1V2AE@1239|Firmicutes,4HFRF@91061|Bacilli,1ZFFX@1386|Bacillus	91061|Bacilli	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
DEZH2_k127_4350497_0	411489.CLOL250_02603	7.931e-101	333.0	COG1373@1|root,COG1373@2|Bacteria,1TP7X@1239|Firmicutes,249UX@186801|Clostridia,36HT4@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
DEZH2_k127_4358123_0	1195236.CTER_5040	5.486e-163	522.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,3WHFT@541000|Ruminococcaceae	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	-	-	-	-	-	-	-	-	-	-	-	-	Anticodon_1,tRNA-synt_1
DEZH2_k127_4358123_2	483218.BACPEC_02723	5.277e-54	194.0	COG2606@1|root,COG2606@2|Bacteria,1V6JF@1239|Firmicutes,24I4E@186801|Clostridia,268WS@186813|unclassified Clostridiales	186801|Clostridia	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
DEZH2_k127_4358123_3	1131462.DCF50_p2427	2.692e-46	169.0	COG1592@1|root,COG1592@2|Bacteria,1VB12@1239|Firmicutes,24JQ6@186801|Clostridia,262FT@186807|Peptococcaceae	186801|Clostridia	C	PFAM Rubredoxin-type Fe(Cys)4 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4358123_1	1487921.DP68_11535	1.478e-117	387.0	COG0477@1|root,COG2814@2|Bacteria,1UY64@1239|Firmicutes,249MW@186801|Clostridia,36RD9@31979|Clostridiaceae	186801|Clostridia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DEZH2_k127_4397097_2	1410632.JHWW01000002_gene2148	8.194e-104	344.0	COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia,27KB3@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133,5.1.3.13	ko:K00067,ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777,R06514	RC00182,RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
DEZH2_k127_4397097_0	768704.Desmer_4166	7.72e-188	590.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,247NE@186801|Clostridia,2648R@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
DEZH2_k127_4397097_4	309803.CTN_0032	2.264e-82	277.0	COG1898@1|root,COG1898@2|Bacteria,2GDVU@200918|Thermotogae	200918|Thermotogae	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
DEZH2_k127_4397097_1	931276.Cspa_c54310	5.949e-140	449.0	COG1209@1|root,COG1209@2|Bacteria,1V301@1239|Firmicutes,247XE@186801|Clostridia,36DE6@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
DEZH2_k127_4397097_3	1235790.C805_00437	2.615e-83	289.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
DEZH2_k127_4431073_1	90814.KL370891_gene1255	2.72e-56	199.0	COG1187@1|root,COG1187@2|Bacteria,1MXQE@1224|Proteobacteria,1RMC7@1236|Gammaproteobacteria,462D0@72273|Thiotrichales	72273|Thiotrichales	J	S4 RNA-binding domain	-	-	5.4.99.21	ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
DEZH2_k127_4431073_0	1410638.JHXJ01000006_gene2570	6.762e-168	554.0	COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,248H7@186801|Clostridia,3WGCC@541000|Ruminococcaceae	186801|Clostridia	G	beta-galactosidase	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Laminin_G_3
DEZH2_k127_4432144_2	1463901.JOIY01000007_gene3173	3.601e-22	99.0	COG4702@1|root,COG4702@2|Bacteria,2IFGG@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the UPF0303 family	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
DEZH2_k127_4432144_3	1144313.PMI10_02079	7.96e-05	53.0	COG3507@1|root,COG3866@1|root,COG4677@1|root,COG3507@2|Bacteria,COG3866@2|Bacteria,COG4677@2|Bacteria,4NEEI@976|Bacteroidetes,1IK65@117743|Flavobacteriia,2NVPT@237|Flavobacterium	976|Bacteroidetes	G	Pectinesterase	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CBM_6,Pectinesterase
DEZH2_k127_4432144_0	1226325.HMPREF1548_05296	4.242e-173	551.0	COG3405@1|root,COG3405@2|Bacteria,1U1E1@1239|Firmicutes,24878@186801|Clostridia,36FZI@31979|Clostridiaceae	186801|Clostridia	G	family 8	-	-	3.2.1.156	ko:K15531	-	-	-	-	ko00000,ko01000	-	GH8	-	Dockerin_1,Glyco_hydro_8,Polysacc_deac_1
DEZH2_k127_4432144_1	994573.T472_0202845	1.184e-23	102.0	COG2233@1|root,COG2233@2|Bacteria,1TQKX@1239|Firmicutes,2485Z@186801|Clostridia,36DN5@31979|Clostridiaceae	186801|Clostridia	F	Permease	uraA	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
DEZH2_k127_4438721_1	1195236.CTER_2709	1.458e-62	225.0	COG0119@1|root,COG0119@2|Bacteria,1V2N0@1239|Firmicutes,24DEG@186801|Clostridia,3WIQ6@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	nifV2	-	2.3.3.14	ko:K02594	ko00620,map00620	-	R00271	RC00004,RC00067,RC02754	ko00000,ko00001,ko01000	-	-	-	HMGL-like
DEZH2_k127_4438721_0	1195236.CTER_2710	8.79e-72	252.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2495J@186801|Clostridia,3WIBV@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	nifV	-	2.3.3.14	ko:K02594	ko00620,map00620	-	R00271	RC00004,RC00067,RC02754	ko00000,ko00001,ko01000	-	-	-	HMGL-like
DEZH2_k127_4438721_3	1195236.CTER_2714	1.276e-35	143.0	arCOG05249@1|root,308XE@2|Bacteria,1V67A@1239|Firmicutes,24J41@186801|Clostridia	186801|Clostridia	S	PFAM Nitrogenase iron-iron accessory protein AnfO	-	-	-	-	-	-	-	-	-	-	-	-	AnfO_nitrog
DEZH2_k127_4438721_2	1195236.CTER_2715	4.974e-50	182.0	COG2849@1|root,COG2849@2|Bacteria,1V5HE@1239|Firmicutes,24AYV@186801|Clostridia,3WJ5V@541000|Ruminococcaceae	186801|Clostridia	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4492645_1	760568.Desku_1684	7.26e-31	125.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,260BN@186807|Peptococcaceae	186801|Clostridia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
DEZH2_k127_4492645_0	1392491.JIAE01000001_gene670	2.948e-31	125.0	COG4443@1|root,COG4443@2|Bacteria,1VEFE@1239|Firmicutes,24QV3@186801|Clostridia,3WKST@541000|Ruminococcaceae	186801|Clostridia	S	Transcriptional Coactivator p15 (PC4)	-	-	-	-	-	-	-	-	-	-	-	-	PC4
DEZH2_k127_4492645_2	699246.HMPREF0868_0664	1.543e-13	76.0	COG1408@1|root,COG1408@2|Bacteria	2|Bacteria	S	Calcineurin-like phosphoesterase	yaeI	-	2.8.3.5	ko:K01028,ko:K07098	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	Metallophos,Metallophos_2
DEZH2_k127_4492645_3	1410638.JHXJ01000027_gene1180	2.231e-06	52.0	COG1408@1|root,COG1408@2|Bacteria,1UU17@1239|Firmicutes,248PS@186801|Clostridia,3WGVG@541000|Ruminococcaceae	186801|Clostridia	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
DEZH2_k127_4563527_0	478749.BRYFOR_06044	7.154e-178	563.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
DEZH2_k127_4563527_1	877411.JMMA01000002_gene2393	2.136e-42	157.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,3WGXK@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
DEZH2_k127_4579509_2	536227.CcarbDRAFT_4238	7.043e-44	162.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,36EB1@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
DEZH2_k127_4579509_1	357809.Cphy_0562	1.205e-63	232.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,223VY@1506553|Lachnoclostridium	186801|Clostridia	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
DEZH2_k127_4579509_3	1410617.JHXH01000002_gene1790	1.181e-33	135.0	COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,24MUB@186801|Clostridia,3WK48@541000|Ruminococcaceae	186801|Clostridia	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
DEZH2_k127_4579509_4	1294142.CINTURNW_1742	2.448e-29	122.0	COG0716@1|root,COG0716@2|Bacteria,1VR7Z@1239|Firmicutes,24QA1@186801|Clostridia,36KSC@31979|Clostridiaceae	186801|Clostridia	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
DEZH2_k127_4579509_0	398512.JQKC01000010_gene129	4.659e-154	505.0	COG1022@1|root,COG1022@2|Bacteria,1TS22@1239|Firmicutes,24AZW@186801|Clostridia,3WHKE@541000|Ruminococcaceae	186801|Clostridia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
DEZH2_k127_4610488_2	1410638.JHXJ01000005_gene2133	1.957e-14	73.0	COG0333@1|root,COG0333@2|Bacteria,1VEFI@1239|Firmicutes,24QM0@186801|Clostridia,3WKRF@541000|Ruminococcaceae	186801|Clostridia	J	Ribosomal L32p protein family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
DEZH2_k127_4610488_4	1122919.KB905580_gene3182	0.0001436	51.0	COG4506@1|root,COG4506@2|Bacteria,1VK4E@1239|Firmicutes,4HR38@91061|Bacilli,26XI1@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF1934)	ywiB	-	-	-	-	-	-	-	-	-	-	-	DUF1934
DEZH2_k127_4610488_1	1410638.JHXJ01000005_gene2135	1.813e-97	327.0	COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,3WGBW@541000|Ruminococcaceae	186801|Clostridia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
DEZH2_k127_4610488_0	1392491.JIAE01000001_gene653	4.936e-120	394.0	COG0564@1|root,COG0564@2|Bacteria,1TR1M@1239|Firmicutes,248W3@186801|Clostridia,3WH5D@541000|Ruminococcaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
DEZH2_k127_4610488_3	1304875.JAFZ01000001_gene1959	7.774e-05	45.0	COG1484@1|root,COG1484@2|Bacteria,3TBI2@508458|Synergistetes	508458|Synergistetes	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
DEZH2_k127_4619771_7	1392491.JIAE01000001_gene1184	7.92e-27	115.0	COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,247S7@186801|Clostridia,3WGWB@541000|Ruminococcaceae	186801|Clostridia	M	Glycosyl transferase family 4	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
DEZH2_k127_4619771_0	1392491.JIAE01000001_gene1185	2.048e-242	761.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,3WHS0@541000|Ruminococcaceae	186801|Clostridia	J	Arginyl tRNA synthetase N terminal dom	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
DEZH2_k127_4619771_1	1392491.JIAE01000001_gene1186	2.327e-218	690.0	COG1164@1|root,COG1164@2|Bacteria,1TPV4@1239|Firmicutes,2495D@186801|Clostridia,3WHMS@541000|Ruminococcaceae	186801|Clostridia	E	Peptidase family M3	pz-A	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3
DEZH2_k127_4619771_2	1392491.JIAE01000001_gene1187	7.451e-140	459.0	COG0144@1|root,COG0144@2|Bacteria,1TPGQ@1239|Firmicutes,247N0@186801|Clostridia,3WGN3@541000|Ruminococcaceae	186801|Clostridia	J	NOL1 NOP2 sun family	rsmF	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI
DEZH2_k127_4619771_4	1121115.AXVN01000146_gene772	3.054e-57	205.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,3XZMM@572511|Blautia	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
DEZH2_k127_4619771_6	1410638.JHXJ01000007_gene1081	3.878e-54	194.0	COG4492@1|root,COG4492@2|Bacteria,1VAJ9@1239|Firmicutes,24MTS@186801|Clostridia,3WK80@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the UPF0735 family	pheB	-	5.4.99.5	ko:K06209	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_4
DEZH2_k127_4619771_3	1392491.JIAE01000001_gene1426	4.782e-125	412.0	COG0460@1|root,COG0460@2|Bacteria,1TQ2H@1239|Firmicutes,248MU@186801|Clostridia,3WGG4@541000|Ruminococcaceae	186801|Clostridia	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
DEZH2_k127_4619771_5	1392491.JIAE01000001_gene1424	7.061e-56	201.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia	186801|Clostridia	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
DEZH2_k127_4627450_4	1449338.JQLU01000005_gene3332	1.278e-37	146.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,4HA41@91061|Bacilli,27F99@186828|Carnobacteriaceae	91061|Bacilli	M	Glycosyl transferase 4-like domain	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
DEZH2_k127_4627450_2	180332.JTGN01000005_gene2718	4.145e-65	228.0	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,25B1X@186801|Clostridia	186801|Clostridia	T	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DEZH2_k127_4627450_5	1449050.JNLE01000005_gene4142	2.814e-13	71.0	COG4585@1|root,COG4585@2|Bacteria,1UUZ9@1239|Firmicutes,248T2@186801|Clostridia,36W11@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
DEZH2_k127_4627450_3	1195236.CTER_4377	3.051e-60	220.0	COG4585@1|root,COG4585@2|Bacteria,1UUZ9@1239|Firmicutes,248T2@186801|Clostridia,3WHW7@541000|Ruminococcaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
DEZH2_k127_4627450_0	1120746.CCNL01000017_gene2393	1.494e-147	472.0	COG1131@1|root,COG1131@2|Bacteria,2NP0I@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DEZH2_k127_4627450_1	1120746.CCNL01000017_gene2392	9.495e-74	260.0	COG0842@1|root,COG0842@2|Bacteria,2NQWE@2323|unclassified Bacteria	2|Bacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
DEZH2_k127_4642883_7	940282.CADQ01000034_gene835	4.234e-06	51.0	2DI18@1|root,301P8@2|Bacteria,1PTHJ@1224|Proteobacteria,2V5D3@28211|Alphaproteobacteria,2JYAW@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4642883_1	1410638.JHXJ01000002_gene1410	5.876e-179	569.0	COG0150@1|root,COG0150@2|Bacteria	2|Bacteria	F	phosphoribosylformylglycinamidine cyclo-ligase activity	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C
DEZH2_k127_4642883_3	292564.Cyagr_0200	1.315e-100	338.0	COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria	1117|Cyanobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
DEZH2_k127_4642883_0	411468.CLOSCI_00606	2.221e-203	640.0	COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,247XK@186801|Clostridia,21ZBG@1506553|Lachnoclostridium	186801|Clostridia	E	Cys/Met metabolism PLP-dependent enzyme	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
DEZH2_k127_4642883_5	937777.Deipe_3068	1.823e-28	119.0	COG3118@1|root,COG3118@2|Bacteria,1WK9V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
DEZH2_k127_4642883_6	720554.Clocl_0609	8.458e-24	104.0	COG0640@1|root,COG0640@2|Bacteria,1VF14@1239|Firmicutes,24MW7@186801|Clostridia,3WJW0@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	pagR	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
DEZH2_k127_4642883_2	1121396.KB893053_gene2356	1.033e-126	415.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,42S6C@68525|delta/epsilon subdivisions,2WPAP@28221|Deltaproteobacteria,2MKIV@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.335	ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_4642883_4	1392491.JIAE01000001_gene1357	1.509e-75	258.0	COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,24848@186801|Clostridia,3WGW3@541000|Ruminococcaceae	186801|Clostridia	F	pyrimidine-nucleoside phosphorylase	pdp	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08925	Glycos_trans_3N,Glycos_transf_3,PYNP_C
DEZH2_k127_4673698_5	665956.HMPREF1032_02834	0.0005285	46.0	2E5I1@1|root,3309D@2|Bacteria,1VG10@1239|Firmicutes	1239|Firmicutes	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
DEZH2_k127_4673698_1	1449050.JNLE01000003_gene327	4.856e-86	307.0	COG4805@1|root,COG4805@2|Bacteria,1TREN@1239|Firmicutes,249U9@186801|Clostridia,36FG3@31979|Clostridiaceae	186801|Clostridia	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
DEZH2_k127_4673698_4	913865.DOT_5782	2.617e-25	112.0	2CGZQ@1|root,33IWK@2|Bacteria,1VPG7@1239|Firmicutes,24WH0@186801|Clostridia,263N6@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4673698_3	913865.DOT_5781	1.072e-29	124.0	COG0681@1|root,COG0681@2|Bacteria,1VAFY@1239|Firmicutes,24P1T@186801|Clostridia,263BI@186807|Peptococcaceae	186801|Clostridia	U	Signal peptidase I	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
DEZH2_k127_4673698_2	1487923.DP73_16415	1.342e-48	187.0	COG1131@1|root,COG1131@2|Bacteria,1V23P@1239|Firmicutes,24H3C@186801|Clostridia,263W7@186807|Peptococcaceae	186801|Clostridia	V	(ABC) transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
DEZH2_k127_4673698_0	913865.DOT_5779	1.875e-102	349.0	2BW0Z@1|root,2Z7QI@2|Bacteria,1TS9E@1239|Firmicutes,24DCN@186801|Clostridia,263WI@186807|Peptococcaceae	186801|Clostridia	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4697897_3	1120998.AUFC01000012_gene496	1.485e-13	76.0	COG0668@1|root,COG0668@2|Bacteria,1TSHU@1239|Firmicutes,249AB@186801|Clostridia	186801|Clostridia	M	mechanosensitive ion channel	-	-	-	ko:K16053	-	-	-	-	ko00000,ko02000	1.A.23.4.5	-	-	MS_channel
DEZH2_k127_4697897_1	318464.IO99_03120	4.865e-94	317.0	COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,253U3@186801|Clostridia,36E29@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_4697897_2	699246.HMPREF0868_1391	6.459e-26	123.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
DEZH2_k127_4697897_0	1121344.JHZO01000003_gene910	1.143e-109	363.0	COG1242@1|root,COG1242@2|Bacteria,1TQ57@1239|Firmicutes,247U3@186801|Clostridia,3WGCQ@541000|Ruminococcaceae	186801|Clostridia	S	radical SAM protein, TIGR01212 family	ytqA	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
DEZH2_k127_4697897_4	1408322.JHYK01000001_gene1608	0.0006291	42.0	COG0524@1|root,COG0524@2|Bacteria,1TT7Y@1239|Firmicutes,249GN@186801|Clostridia,27JFP@186928|unclassified Lachnospiraceae	186801|Clostridia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
DEZH2_k127_4743049_1	1410638.JHXJ01000033_gene21	8.825e-26	108.0	COG0227@1|root,COG0227@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
DEZH2_k127_4743049_0	1392491.JIAE01000001_gene2434	3.001e-103	348.0	COG0791@1|root,COG0791@2|Bacteria,1V47C@1239|Firmicutes,24J59@186801|Clostridia,3WJTF@541000|Ruminococcaceae	186801|Clostridia	M	PFAM NlpC P60 family	-	-	3.4.14.13	ko:K20742	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	NLPC_P60,SH3_3
DEZH2_k127_4743049_2	1121335.Clst_2364	4.039e-25	110.0	COG0736@1|root,COG0736@2|Bacteria,1VA0T@1239|Firmicutes,24RC0@186801|Clostridia,3WKK1@541000|Ruminococcaceae	186801|Clostridia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS01470	ACPS
DEZH2_k127_4743049_3	877411.JMMA01000002_gene2283	2.161e-08	57.0	COG1484@1|root,COG1484@2|Bacteria,1TPKM@1239|Firmicutes,2483D@186801|Clostridia,3WJBS@541000|Ruminococcaceae	186801|Clostridia	L	DNA replication protein	dnaC	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
DEZH2_k127_4754154_5	1392491.JIAE01000001_gene1335	7.029e-27	123.0	2DBSS@1|root,2ZATI@2|Bacteria,1V481@1239|Firmicutes,24C13@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
DEZH2_k127_4754154_2	1392491.JIAE01000001_gene1334	9.402e-75	270.0	COG3225@1|root,COG3225@2|Bacteria,1TT1J@1239|Firmicutes,24BC2@186801|Clostridia	186801|Clostridia	N	-transport system	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_transp_aux
DEZH2_k127_4754154_3	1410638.JHXJ01000013_gene2311	5.36e-54	199.0	COG1277@1|root,COG1277@2|Bacteria,1UZXS@1239|Firmicutes,248ME@186801|Clostridia,3WI9V@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_5
DEZH2_k127_4754154_1	1410638.JHXJ01000013_gene2310	7.212e-115	378.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,3WH5S@541000|Ruminococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_4754154_4	1392491.JIAE01000001_gene1331	1.102e-44	171.0	COG3884@1|root,COG3884@2|Bacteria	2|Bacteria	I	thiolester hydrolase activity	-	-	3.1.2.21	ko:K01071	ko00061,ko01100,map00061,map01100	-	R04014,R08157,R08158	RC00014,RC00039	ko00000,ko00001,ko01000,ko01004	-	-	-	Acyl-ACP_TE
DEZH2_k127_4754154_0	428125.CLOLEP_02631	8.592e-154	497.0	COG2270@1|root,COG2270@2|Bacteria,1TRTH@1239|Firmicutes,24AYI@186801|Clostridia,3WHYR@541000|Ruminococcaceae	186801|Clostridia	S	Major Facilitator	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
DEZH2_k127_478171_2	579138.Zymop_0042	5.577e-17	83.0	COG2261@1|root,COG2261@2|Bacteria,1N8B3@1224|Proteobacteria,2UKNY@28211|Alphaproteobacteria,2K64H@204457|Sphingomonadales	204457|Sphingomonadales	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
DEZH2_k127_478171_0	665956.HMPREF1032_01565	1.572e-175	561.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,3WIPI@541000|Ruminococcaceae	186801|Clostridia	C	Aldehyde dehydrogenase family	ywdH	-	1.2.1.3,1.2.1.8,1.2.99.10	ko:K00128,ko:K00130,ko:K22445	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
DEZH2_k127_478171_1	768706.Desor_4312	3.821e-121	401.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,249X1@186801|Clostridia,2649J@186807|Peptococcaceae	186801|Clostridia	C	Alcohol dehydrogenase class IV	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
DEZH2_k127_4818522_5	1195236.CTER_0681	1.09e-44	181.0	COG1305@1|root,COG1305@2|Bacteria,1TP8K@1239|Firmicutes,24CZV@186801|Clostridia,3WI6I@541000|Ruminococcaceae	186801|Clostridia	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
DEZH2_k127_4818522_1	1392491.JIAE01000001_gene2303	7.781e-225	706.0	COG0498@1|root,COG0498@2|Bacteria,1TPR0@1239|Firmicutes,248YY@186801|Clostridia,3WGWF@541000|Ruminococcaceae	186801|Clostridia	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS16355	PALP,Thr_synth_N
DEZH2_k127_4818522_2	1392491.JIAE01000001_gene2305	1.451e-108	369.0	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,3WGH0@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
DEZH2_k127_4818522_8	1423747.BAMJ01000024_gene1588	6.071e-20	96.0	COG2246@1|root,COG2246@2|Bacteria,1VESW@1239|Firmicutes,4HNK7@91061|Bacilli,3F4GH@33958|Lactobacillaceae	91061|Bacilli	S	Teichoic acid glycosylation protein	gtcA2	-	-	-	-	-	-	-	-	-	-	-	GtrA
DEZH2_k127_4818522_0	1392491.JIAE01000001_gene2308	1.268e-225	726.0	COG4193@1|root,COG4193@2|Bacteria,1TRTM@1239|Firmicutes,24C4N@186801|Clostridia,3WHI0@541000|Ruminococcaceae	186801|Clostridia	GT	SH3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Dockerin_1,Glucosaminidase,SH3_3
DEZH2_k127_4818522_3	1392491.JIAE01000001_gene2309	1.353e-66	233.0	COG1896@1|root,COG1896@2|Bacteria,1TSDU@1239|Firmicutes,24FT8@186801|Clostridia,3WGMJ@541000|Ruminococcaceae	186801|Clostridia	S	PFAM metal-dependent phosphohydrolase HD sub domain	yfbR	-	3.1.3.89	ko:K07023,ko:K08722	ko00240,ko01100,map00240,map01100	-	R01569,R01664,R01968,R02088,R02102,R10776	RC00017	ko00000,ko00001,ko01000	-	-	-	HD_2,HD_3
DEZH2_k127_4818522_6	1291050.JAGE01000002_gene3421	5.205e-40	153.0	COG0232@1|root,COG0232@2|Bacteria,1TPEI@1239|Firmicutes,247Q1@186801|Clostridia	186801|Clostridia	F	Belongs to the dGTPase family. Type 2 subfamily	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
DEZH2_k127_4836960_2	1410638.JHXJ01000017_gene625	1.106e-69	243.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,3WH2A@541000|Ruminococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
DEZH2_k127_4836960_1	1382304.JNIL01000001_gene367	4.744e-73	254.0	COG1768@1|root,COG1768@2|Bacteria,1V3XB@1239|Firmicutes,4HU4P@91061|Bacilli	91061|Bacilli	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07099	-	-	-	-	ko00000	-	-	-	Metallophos
DEZH2_k127_4836960_0	1410638.JHXJ01000017_gene628	3.321e-82	282.0	COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,24824@186801|Clostridia,3WNGU@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF1732)	yicC	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
DEZH2_k127_4836960_3	699246.HMPREF0868_1485	1.523e-23	103.0	COG2052@1|root,COG2052@2|Bacteria,1VA40@1239|Firmicutes,24MXV@186801|Clostridia	186801|Clostridia	S	Belongs to the UPF0296 family	NPD7_560	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
DEZH2_k127_4836960_4	699246.HMPREF0868_1484	5.574e-09	58.0	COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia,2691D@186813|unclassified Clostridiales	186801|Clostridia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
DEZH2_k127_48542_13	1291050.JAGE01000001_gene359	1.472e-08	55.0	COG0347@1|root,COG0347@2|Bacteria,1VASB@1239|Firmicutes,24J84@186801|Clostridia,3WJG4@541000|Ruminococcaceae	186801|Clostridia	K	PFAM Nitrogen regulatory protein P-II	-	-	-	ko:K02589	-	-	-	-	ko00000	-	-	-	P-II
DEZH2_k127_48542_0	1195236.CTER_2701	2.438e-154	490.0	COG1348@1|root,COG1348@2|Bacteria,1TPXR@1239|Firmicutes,247KJ@186801|Clostridia,3WHCC@541000|Ruminococcaceae	186801|Clostridia	P	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein	nifH	-	1.18.6.1	ko:K02588	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_NifH
DEZH2_k127_48542_8	1195236.CTER_2711	3.33e-34	142.0	COG0725@1|root,COG0725@2|Bacteria,1U9U3@1239|Firmicutes,249VA@186801|Clostridia,3WISF@541000|Ruminococcaceae	186801|Clostridia	P	ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	iHN637.CLJU_RS12820	SBP_bac_11
DEZH2_k127_48542_12	1200567.JNKD01000030_gene1899	2.734e-17	92.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,1RN71@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC transporter, periplasmic molybdate-binding protein	modA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015098,GO:0015103,GO:0015318,GO:0015399,GO:0015405,GO:0015412,GO:0015689,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0030151,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0034220,GO:0042597,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043169,GO:0043225,GO:0043492,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0099133,GO:1901359	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	iECO111_1330.ECO111_0773,iPC815.YPO1145	SBP_bac_11
DEZH2_k127_48542_4	1195236.CTER_2712	1.065e-82	283.0	COG4149@1|root,COG4149@2|Bacteria,1TRNA@1239|Firmicutes,24BR9@186801|Clostridia,3WIYG@541000|Ruminococcaceae	186801|Clostridia	P	Molybdate ABC transporter	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
DEZH2_k127_48542_3	1123511.KB905847_gene3114	2.881e-93	318.0	COG1118@1|root,COG1118@2|Bacteria,1UI1E@1239|Firmicutes,4H3R1@909932|Negativicutes	909932|Negativicutes	P	ABC transporter, ATP-binding protein	modB2	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran
DEZH2_k127_48542_5	604331.AUHY01000086_gene164	2.805e-68	241.0	COG4221@1|root,COG4221@2|Bacteria,1WID9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
DEZH2_k127_48542_7	411461.DORFOR_02186	4.808e-36	139.0	COG3668@1|root,COG3668@2|Bacteria,1VD9X@1239|Firmicutes,24K2R@186801|Clostridia,27WUY@189330|Dorea	186801|Clostridia	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
DEZH2_k127_48542_6	525282.HMPREF0391_11230	2.616e-40	151.0	COG3077@1|root,COG3077@2|Bacteria,1VGJW@1239|Firmicutes,24JNU@186801|Clostridia,22HU0@1570339|Peptoniphilaceae	186801|Clostridia	L	RelB antitoxin	-	-	-	ko:K07473	-	-	-	-	ko00000,ko02048	-	-	-	RelB
DEZH2_k127_48542_1	268407.PWYN_19590	3.103e-100	336.0	COG0604@1|root,COG0604@2|Bacteria,1TSWF@1239|Firmicutes,4HANV@91061|Bacilli,274FR@186822|Paenibacillaceae	91061|Bacilli	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
DEZH2_k127_48542_2	158190.SpiGrapes_2377	2.219e-99	334.0	COG0604@1|root,COG0604@2|Bacteria,2J6WP@203691|Spirochaetes	203691|Spirochaetes	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
DEZH2_k127_48542_10	562743.JH976434_gene1835	7.85e-27	111.0	COG1476@1|root,COG1476@2|Bacteria,1VEKB@1239|Firmicutes,4HR3N@91061|Bacilli	91061|Bacilli	K	Helix-turn-helix domain	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
DEZH2_k127_48542_11	562743.JH976434_gene1834	4.276e-24	104.0	2EGE1@1|root,33A5Y@2|Bacteria,1VV4C@1239|Firmicutes,4HVGE@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_4906742_3	1392491.JIAE01000001_gene2516	2.036e-18	85.0	COG0106@1|root,COG0106@2|Bacteria,1V1IR@1239|Firmicutes,24GBJ@186801|Clostridia,3WH1N@541000|Ruminococcaceae	186801|Clostridia	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
DEZH2_k127_4906742_4	1500281.JQKZ01000023_gene908	6.607e-16	81.0	COG0106@1|root,COG0106@2|Bacteria,4NEEX@976|Bacteroidetes,1HWQ2@117743|Flavobacteriia,3ZPSP@59732|Chryseobacterium	976|Bacteroidetes	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
DEZH2_k127_4906742_0	1392491.JIAE01000001_gene2515	7.568e-174	551.0	COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,3WGQE@541000|Ruminococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05755	His_biosynth
DEZH2_k127_4906742_1	720554.Clocl_3922	2.337e-33	131.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1UYNA@1239|Firmicutes,247RS@186801|Clostridia,3WJ30@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05760	His_biosynth,PRA-CH,PRA-PH
DEZH2_k127_4906742_2	1392491.JIAE01000001_gene2511	2.627e-21	95.0	COG0267@1|root,COG0267@2|Bacteria,1VEJ4@1239|Firmicutes,24QK0@186801|Clostridia,3WKQN@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
DEZH2_k127_4963115_2	1292035.H476_1561	2.218e-31	124.0	COG0454@1|root,COG0454@2|Bacteria	2|Bacteria	K	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
DEZH2_k127_4963115_1	1123277.KB893206_gene3333	8.071e-54	194.0	COG1247@1|root,COG1247@2|Bacteria,4NPIE@976|Bacteroidetes,47RI6@768503|Cytophagia	976|Bacteroidetes	M	Acetyltransferase (GNAT) domain	yncA	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
DEZH2_k127_4963115_0	585394.RHOM_14235	1.101e-126	410.0	COG1619@1|root,COG1619@2|Bacteria,1TRBB@1239|Firmicutes,24ABA@186801|Clostridia	186801|Clostridia	V	LD-carboxypeptidase	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
DEZH2_k127_4970971_1	642492.Clole_1124	1.109e-61	214.0	COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,247QY@186801|Clostridia	186801|Clostridia	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
DEZH2_k127_4970971_0	1392491.JIAE01000001_gene961	4.143e-315	973.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,3WGES@541000|Ruminococcaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
DEZH2_k127_4970971_2	742738.HMPREF9460_02401	6.13e-20	89.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,267YE@186813|unclassified Clostridiales	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
DEZH2_k127_5001326_1	1392491.JIAE01000001_gene1354	3.435e-37	145.0	COG0326@1|root,COG0326@2|Bacteria,1TQEU@1239|Firmicutes,247ND@186801|Clostridia,3WGY6@541000|Ruminococcaceae	186801|Clostridia	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
DEZH2_k127_5001326_2	1392491.JIAE01000001_gene1419	2.61e-12	68.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,3WGRN@541000|Ruminococcaceae	186801|Clostridia	F	phosphoribosylformylglycinamidine synthase	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
DEZH2_k127_5001326_0	1392491.JIAE01000001_gene1419	0.0	1100.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,3WGRN@541000|Ruminococcaceae	186801|Clostridia	F	phosphoribosylformylglycinamidine synthase	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
DEZH2_k127_5003139_0	1410638.JHXJ01000024_gene812	2.706e-137	446.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,3WHW2@541000|Ruminococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
DEZH2_k127_5003139_2	1392491.JIAE01000001_gene364	1.703e-33	131.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,24RIE@186801|Clostridia,3WK9F@541000|Ruminococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
DEZH2_k127_5003139_1	97138.C820_00669	1.732e-85	285.0	COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,248XN@186801|Clostridia,36FC0@31979|Clostridiaceae	186801|Clostridia	J	L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp	aspS	-	6.1.1.12,6.1.1.23	ko:K01876,ko:K09759	ko00970,map00970	M00359,M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_2,tRNA_anti-codon
DEZH2_k127_5009184_0	573061.Clocel_1043	8.275e-120	399.0	COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,36DVM@31979|Clostridiaceae	186801|Clostridia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
DEZH2_k127_5009184_1	1121335.Clst_1955	1.984e-106	347.0	COG4868@1|root,COG4868@2|Bacteria,1TQYE@1239|Firmicutes,247YI@186801|Clostridia,3WHJQ@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF1846
DEZH2_k127_5012713_8	1292035.H476_2319	1.506e-45	169.0	COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,24AGW@186801|Clostridia,25S3A@186804|Peptostreptococcaceae	186801|Clostridia	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
DEZH2_k127_5012713_4	1392491.JIAE01000001_gene1458	1.175e-92	321.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,3WJ4Y@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
DEZH2_k127_5012713_0	1392491.JIAE01000001_gene1457	9.896e-166	534.0	COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,2482Y@186801|Clostridia,3WGSQ@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
DEZH2_k127_5012713_1	1392491.JIAE01000001_gene1456	6.203e-164	529.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,3WMXT@541000|Ruminococcaceae	186801|Clostridia	L	MutS domain II	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
DEZH2_k127_5012713_2	1392491.JIAE01000001_gene1456	5.102e-143	464.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,3WMXT@541000|Ruminococcaceae	186801|Clostridia	L	MutS domain II	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
DEZH2_k127_5012713_3	720554.Clocl_1743	1.15e-142	473.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,3WHC5@541000|Ruminococcaceae	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
DEZH2_k127_5012713_5	1121335.Clst_0843	2.443e-75	263.0	COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia,3WGGD@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
DEZH2_k127_5012713_10	931276.Cspa_c32350	9.961e-10	64.0	COG1923@1|root,COG1923@2|Bacteria,1VEGI@1239|Firmicutes,24QIM@186801|Clostridia,36KQP@31979|Clostridiaceae	186801|Clostridia	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
DEZH2_k127_5012713_6	1410638.JHXJ01000002_gene1324	8.839e-53	193.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,3WHGN@541000|Ruminococcaceae	186801|Clostridia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
DEZH2_k127_5012713_7	318464.IO99_06165	1.474e-52	188.0	COG4994@1|root,COG4994@2|Bacteria,1VC72@1239|Firmicutes,24JSH@186801|Clostridia,36JU1@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
DEZH2_k127_5079969_2	1195236.CTER_3081	5.25e-06	50.0	COG2367@1|root,COG2367@2|Bacteria,1V5VP@1239|Firmicutes,25B0P@186801|Clostridia,3WS8C@541000|Ruminococcaceae	186801|Clostridia	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2,LysM,PG_binding_1
DEZH2_k127_5079969_1	720554.Clocl_0908	8.859e-72	250.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,247NA@186801|Clostridia,3WN6P@541000|Ruminococcaceae	186801|Clostridia	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
DEZH2_k127_5079969_0	720554.Clocl_0907	1.227e-187	591.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,3WGGK@541000|Ruminococcaceae	186801|Clostridia	C	TIGRFAM formate acetyltransferase	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
DEZH2_k127_5155089_11	1392491.JIAE01000001_gene2332	8.191e-05	48.0	COG4123@1|root,COG4123@2|Bacteria,1TQ25@1239|Firmicutes,249UH@186801|Clostridia,3WH2K@541000|Ruminococcaceae	186801|Clostridia	S	Methyltransferase small domain	yfiC	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS,Methyltransf_31
DEZH2_k127_5155089_10	653733.Selin_0818	2.731e-24	102.0	COG2768@1|root,COG2768@2|Bacteria	2|Bacteria	-	-	fdxA	GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114	-	-	-	-	-	-	-	-	-	-	Fer4
DEZH2_k127_5155089_0	720554.Clocl_4027	3.274e-101	340.0	COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,247Q6@186801|Clostridia,3WHA4@541000|Ruminococcaceae	186801|Clostridia	S	PSP1 C-terminal domain protein	yaaT	-	-	-	-	-	-	-	-	-	-	-	PSP1
DEZH2_k127_5155089_3	1392491.JIAE01000001_gene2336	6.43e-75	263.0	COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia,3WI7S@541000|Ruminococcaceae	186801|Clostridia	L	DNA polymerase III	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
DEZH2_k127_5155089_6	699246.HMPREF0868_1014	3.374e-45	166.0	COG3870@1|root,COG3870@2|Bacteria,1V6NI@1239|Firmicutes,24N37@186801|Clostridia	186801|Clostridia	S	protein conserved in bacteria	yaaQ	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
DEZH2_k127_5155089_5	1392491.JIAE01000001_gene2337	3.006e-60	214.0	COG0125@1|root,COG0125@2|Bacteria,1V1HE@1239|Firmicutes,24HHC@186801|Clostridia,3WJF4@541000|Ruminococcaceae	186801|Clostridia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
DEZH2_k127_5155089_4	580327.Tthe_0076	3.53e-63	235.0	COG1982@1|root,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia,42F01@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Orn Lys Arg decarboxylase major region	-	-	4.1.1.18,4.1.1.19	ko:K01582,ko:K01585	ko00310,ko00330,ko00960,ko01100,ko01110,map00310,map00330,map00960,map01100,map01110	M00133	R00462,R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
DEZH2_k127_5155089_7	981383.AEWH01000020_gene2428	1.333e-40	155.0	COG0801@1|root,COG0801@2|Bacteria,1V6PR@1239|Firmicutes,4HIMG@91061|Bacilli	91061|Bacilli	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
DEZH2_k127_5155089_9	398512.JQKC01000080_gene2728	9.877e-25	108.0	COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,24MN5@186801|Clostridia,3WKK7@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
DEZH2_k127_5155089_2	386415.NT01CX_0375	8.158e-79	273.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,36EFV@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03115	Pterin_bind
DEZH2_k127_5155089_1	1392491.JIAE01000001_gene2342	8.114e-99	325.0	COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,3WIA5@541000|Ruminococcaceae	186801|Clostridia	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
DEZH2_k127_5155089_8	1392491.JIAE01000001_gene2343	7.21e-37	141.0	COG2207@1|root,COG2207@2|Bacteria,1TQ2W@1239|Firmicutes,24AFS@186801|Clostridia,3WIRY@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18,HTH_AraC
DEZH2_k127_5173031_0	1392491.JIAE01000001_gene1138	4.84e-224	701.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,3WGW6@541000|Ruminococcaceae	186801|Clostridia	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
DEZH2_k127_5173031_5	1410638.JHXJ01000023_gene841	1.704e-31	125.0	2E6AD@1|root,330Y9@2|Bacteria,1VGZN@1239|Firmicutes,2589N@186801|Clostridia,3WM9E@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5173031_4	1392491.JIAE01000001_gene1135	3.783e-53	192.0	COG0262@1|root,COG0262@2|Bacteria,1VB80@1239|Firmicutes,24FTH@186801|Clostridia,3WK8V@541000|Ruminococcaceae	186801|Clostridia	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
DEZH2_k127_5173031_1	1392491.JIAE01000001_gene1134	7.75e-153	485.0	COG0207@1|root,COG0207@2|Bacteria,1TSIR@1239|Firmicutes,249QG@186801|Clostridia,3WHH9@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
DEZH2_k127_5173031_2	537013.CLOSTMETH_00576	1.711e-119	389.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,3WGVM@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
DEZH2_k127_5189882_0	1297617.JPJD01000021_gene1514	7.053e-176	557.0	COG1328@1|root,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,267Y1@186813|unclassified Clostridiales	186801|Clostridia	F	Anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
DEZH2_k127_5189882_2	1392491.JIAE01000001_gene2425	9.852e-98	329.0	COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,249SY@186801|Clostridia,3WHA2@541000|Ruminococcaceae	186801|Clostridia	I	lipid kinase, YegS Rv2252 BmrU family	dagK	-	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
DEZH2_k127_5189882_1	1392491.JIAE01000001_gene2426	1.493e-131	441.0	COG0760@1|root,COG0760@2|Bacteria,1TSCQ@1239|Firmicutes	1239|Firmicutes	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	-	-	5.2.1.8	ko:K03770,ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N_3
DEZH2_k127_5189882_3	198094.BA_2044	5.31e-27	113.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,4HGZI@91061|Bacilli,1ZQ1K@1386|Bacillus	91061|Bacilli	G	Belongs to the phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
DEZH2_k127_5236994_1	635013.TherJR_1806	8.059e-133	428.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,2608H@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
DEZH2_k127_5236994_0	580331.Thit_0465	1.553e-152	511.0	COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,42FCZ@68295|Thermoanaerobacterales	186801|Clostridia	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
DEZH2_k127_526017_2	1232428.CAVO010000022_gene878	3.399e-26	110.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,4H2G0@909932|Negativicutes	909932|Negativicutes	S	Flavoprotein family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
DEZH2_k127_526017_0	1449126.JQKL01000009_gene363	9.349e-113	381.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,26ARS@186813|unclassified Clostridiales	186801|Clostridia	EH	chorismate binding enzyme	pabB	-	2.6.1.85,4.1.3.27,4.1.3.38	ko:K01657,ko:K01665,ko:K03342,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716,R05553	RC00010,RC01418,RC01843,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Anth_synt_I_N,Chorismate_bind
DEZH2_k127_526017_1	509191.AEDB02000035_gene2121	6.356e-34	141.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,25CC4@186801|Clostridia,3WQ0M@541000|Ruminococcaceae	186801|Clostridia	EH	Amino-transferase class IV	ilvE2	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
DEZH2_k127_5287085_4	1321778.HMPREF1982_03126	8.076e-15	77.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,26831@186813|unclassified Clostridiales	186801|Clostridia	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
DEZH2_k127_5287085_0	1235800.C819_02559	6.401e-167	540.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,27IC9@186928|unclassified Lachnospiraceae	186801|Clostridia	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
DEZH2_k127_5287085_1	1195236.CTER_5153	4.499e-107	358.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248IH@186801|Clostridia,3WJ5F@541000|Ruminococcaceae	186801|Clostridia	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
DEZH2_k127_5287085_2	588581.Cpap_3593	1.202e-61	218.0	COG0503@1|root,COG0503@2|Bacteria,1V1DU@1239|Firmicutes,249VC@186801|Clostridia,3WIGD@541000|Ruminococcaceae	186801|Clostridia	F	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis	xpt	-	2.4.2.22	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
DEZH2_k127_5287085_3	699246.HMPREF0868_1454	6.967e-55	200.0	COG0664@1|root,COG0664@2|Bacteria,1TSP9@1239|Firmicutes,24FRD@186801|Clostridia	186801|Clostridia	K	Cyclic nucleotide-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
DEZH2_k127_5287085_5	935948.KE386494_gene519	8.88e-13	70.0	COG1820@1|root,COG1820@2|Bacteria,1TPFK@1239|Firmicutes,2481N@186801|Clostridia,42FJJ@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
DEZH2_k127_5290500_2	1392491.JIAE01000001_gene636	1.879e-56	201.0	COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,24HDH@186801|Clostridia,3WJ9P@541000|Ruminococcaceae	186801|Clostridia	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
DEZH2_k127_5290500_3	1163671.JAGI01000002_gene2394	6.018e-56	205.0	COG0655@1|root,COG0655@2|Bacteria,1V5DA@1239|Firmicutes,24HQZ@186801|Clostridia,36VWD@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DEZH2_k127_5290500_0	398512.JQKC01000002_gene2030	4.319e-182	576.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,3WGXW@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
DEZH2_k127_5290500_1	1392491.JIAE01000001_gene633	1.387e-83	280.0	COG0220@1|root,COG0220@2|Bacteria,1TQCA@1239|Firmicutes,248YR@186801|Clostridia,3WJXQ@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
DEZH2_k127_5434756_0	1403313.AXBR01000003_gene3998	7.846e-95	325.0	COG0738@1|root,COG0738@2|Bacteria,1TPB5@1239|Firmicutes,4HAUM@91061|Bacilli,1ZDHE@1386|Bacillus	91061|Bacilli	G	Major Facilitator Superfamily	-	-	-	ko:K08174	-	-	-	-	ko00000,ko02000	2.A.1.7	-	-	MFS_1
DEZH2_k127_5434756_1	653733.Selin_1336	1.647e-11	65.0	COG4198@1|root,COG4198@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015,SusD-like,SusD-like_2
DEZH2_k127_5458735_1	632245.CLP_3370	2.937e-113	370.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,36DMF@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DEZH2_k127_5458735_4	877411.JMMA01000002_gene523	1.001e-30	124.0	COG1695@1|root,COG1695@2|Bacteria,1VAGB@1239|Firmicutes,24MZ2@186801|Clostridia,3WM2A@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
DEZH2_k127_5458735_7	877411.JMMA01000002_gene524	3.215e-07	55.0	29VBI@1|root,30GRR@2|Bacteria,1UGHT@1239|Firmicutes,25Q5D@186801|Clostridia,3WR4G@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5458735_5	293826.Amet_4174	3.143e-08	65.0	2EPHD@1|root,33H40@2|Bacteria,1UDZ6@1239|Firmicutes,24IBV@186801|Clostridia,36IWE@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
DEZH2_k127_5458735_6	293826.Amet_4173	1.184e-07	64.0	COG0577@1|root,COG0577@2|Bacteria,1VEXI@1239|Firmicutes,259VP@186801|Clostridia,36PT1@31979|Clostridiaceae	186801|Clostridia	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5458735_3	431943.CKL_0393	2.46e-56	204.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,36DXW@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_5458735_0	138119.DSY0756	8.371e-127	411.0	COG2378@1|root,COG2378@2|Bacteria,1TS78@1239|Firmicutes,25C7I@186801|Clostridia,260XS@186807|Peptococcaceae	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
DEZH2_k127_5458735_2	645991.Sgly_1305	1.299e-65	226.0	COG3708@1|root,COG3708@2|Bacteria,1V7HJ@1239|Firmicutes,24KUR@186801|Clostridia,261RN@186807|Peptococcaceae	186801|Clostridia	K	PFAM Bacterial transcription activator, effector binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cass2,Zn_ribbon_2
DEZH2_k127_5492185_2	411474.COPEUT_01109	5.75e-80	271.0	COG0463@1|root,COG0463@2|Bacteria,1TPR3@1239|Firmicutes,248Q5@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
DEZH2_k127_5492185_1	1392491.JIAE01000001_gene2455	5.888e-136	466.0	COG4485@1|root,COG4485@2|Bacteria,1TRR1@1239|Firmicutes,24BHM@186801|Clostridia,3WHJ5@541000|Ruminococcaceae	186801|Clostridia	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
DEZH2_k127_5492185_3	1120746.CCNL01000011_gene1545	2.595e-69	248.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,2NPG2@2323|unclassified Bacteria	2|Bacteria	H	biotin acetyl-CoA-carboxylase ligase	birA	GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837	6.3.4.15	ko:K03524,ko:K04096	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
DEZH2_k127_5492185_0	1392491.JIAE01000001_gene2454	5.823e-246	772.0	COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,3WGEY@541000|Ruminococcaceae	186801|Clostridia	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain	pgcA	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
DEZH2_k127_5492185_4	1392491.JIAE01000001_gene2453	2.543e-66	231.0	COG2813@1|root,COG2813@2|Bacteria,1V1BG@1239|Firmicutes,24IJI@186801|Clostridia,3WPFD@541000|Ruminococcaceae	186801|Clostridia	J	Lysine methyltransferase	-	-	2.1.1.172	ko:K00564	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS
DEZH2_k127_5495101_2	926692.AZYG01000054_gene2255	1.763e-41	159.0	COG2159@1|root,COG2159@2|Bacteria,1VB27@1239|Firmicutes	1239|Firmicutes	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
DEZH2_k127_5495101_1	509191.AEDB02000099_gene3995	4.231e-50	188.0	COG5482@1|root,COG5482@2|Bacteria,1V3FI@1239|Firmicutes,24IKI@186801|Clostridia,3WPKS@541000|Ruminococcaceae	186801|Clostridia	S	Putative PD-(D/E)XK phosphodiesterase (DUF2161)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2161
DEZH2_k127_5495101_0	857293.CAAU_0148	4.977e-105	351.0	COG3507@1|root,COG3507@2|Bacteria,1TP5K@1239|Firmicutes,247R2@186801|Clostridia,36ES1@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	DUF1349,Glyco_hydro_43
DEZH2_k127_5513303_3	935836.JAEL01000003_gene483	6.784e-72	249.0	2AAUU@1|root,3107N@2|Bacteria,1V4DJ@1239|Firmicutes,4IVBK@91061|Bacilli	91061|Bacilli	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5513303_5	645991.Sgly_1996	0.0001178	46.0	COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1UY3J@1239|Firmicutes,25B36@186801|Clostridia,261A1@186807|Peptococcaceae	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL
DEZH2_k127_5513303_1	931626.Awo_c04110	2.481e-83	282.0	COG2199@1|root,COG2202@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria,1UYXA@1239|Firmicutes	1239|Firmicutes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3
DEZH2_k127_5513303_2	742735.HMPREF9467_01614	6.107e-83	280.0	COG1394@1|root,COG1394@2|Bacteria,1TQ1Y@1239|Firmicutes,247TC@186801|Clostridia,21XKD@1506553|Lachnoclostridium	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
DEZH2_k127_5513303_0	1507.HMPREF0262_01905	1.474e-148	473.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,36DRP@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
DEZH2_k127_5513303_4	562970.Btus_2142	2.28e-06	51.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,4H9R3@91061|Bacilli,277XX@186823|Alicyclobacillaceae	91061|Bacilli	G	Belongs to the phosphoglycerate kinase family	pgk	GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iSB619.SA_RS04145	PGK
DEZH2_k127_5521058_0	350688.Clos_1206	2.217e-170	565.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,36EWE@31979|Clostridiaceae	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
DEZH2_k127_5521058_3	1392491.JIAE01000001_gene1140	2.11e-65	230.0	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,24GFQ@186801|Clostridia,3WJC8@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
DEZH2_k127_5521058_1	1392491.JIAE01000001_gene1147	1.949e-168	535.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,3WG9I@541000|Ruminococcaceae	186801|Clostridia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
DEZH2_k127_5521058_2	316274.Haur_0685	8.574e-71	254.0	COG0606@1|root,COG0606@2|Bacteria,2G65P@200795|Chloroflexi,37511@32061|Chloroflexia	32061|Chloroflexia	O	PFAM magnesium chelatase ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
DEZH2_k127_560608_3	1280680.AUJU01000016_gene3958	5.509e-23	100.0	COG3682@1|root,COG3682@2|Bacteria,1VBDG@1239|Firmicutes,24MUX@186801|Clostridia,4BZI3@830|Butyrivibrio	186801|Clostridia	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
DEZH2_k127_560608_0	203119.Cthe_3127	2.389e-73	273.0	COG4219@1|root,COG4219@2|Bacteria,1TQ0K@1239|Firmicutes,24AVI@186801|Clostridia,3WJSD@541000|Ruminococcaceae	186801|Clostridia	KT	Peptidase, M56	-	-	-	-	-	-	-	-	-	-	-	-	DUF4825,DUF4829,DUF5301,Peptidase_M56
DEZH2_k127_560608_2	1280696.ATVY01000086_gene2001	2.698e-23	112.0	29XMI@1|root,30JCV@2|Bacteria,1U2J7@1239|Firmicutes,25P29@186801|Clostridia,4C0HG@830|Butyrivibrio	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_560608_5	203119.Cthe_0076	6.149e-15	79.0	COG4980@1|root,COG4980@2|Bacteria,1VK4M@1239|Firmicutes,24VID@186801|Clostridia	186801|Clostridia	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
DEZH2_k127_560608_6	755731.Clo1100_1020	5.015e-14	76.0	2EHWB@1|root,33XVJ@2|Bacteria,1VVR6@1239|Firmicutes,25PG1@186801|Clostridia,36Q4D@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_560608_4	1304866.K413DRAFT_4362	1.12e-15	78.0	COG2608@1|root,COG2608@2|Bacteria,1VK5F@1239|Firmicutes,24R4Z@186801|Clostridia	186801|Clostridia	P	Heavy-metal-associated domain	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
DEZH2_k127_560608_1	357809.Cphy_2119	3.592e-34	136.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,1TQ02@1239|Firmicutes,249HC@186801|Clostridia,21ZAN@1506553|Lachnoclostridium	186801|Clostridia	P	cytochrome c biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
DEZH2_k127_569216_0	1392491.JIAE01000001_gene2079	1.424e-75	260.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,25C8E@186801|Clostridia,3WHQ1@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	prmC	-	-	-	-	-	-	-	-	-	-	-	DUF1385,MTS
DEZH2_k127_569216_1	1392491.JIAE01000001_gene2078	5.748e-52	196.0	COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia,3WGK1@541000|Ruminococcaceae	186801|Clostridia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
DEZH2_k127_569216_3	926569.ANT_00680	2.981e-10	64.0	COG4481@1|root,COG4481@2|Bacteria,2G7GI@200795|Chloroflexi	200795|Chloroflexi	S	Bacterial protein of unknown function (DUF951)	-	-	-	-	-	-	-	-	-	-	-	-	DUF951
DEZH2_k127_569216_2	1120746.CCNL01000010_gene1407	9.157e-28	118.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	M1-874	-	-	ko:K13638,ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	DUF1836
DEZH2_k127_570985_0	1235835.C814_03083	2.5e-57	203.0	COG0825@1|root,COG0825@2|Bacteria,1UHNS@1239|Firmicutes,25E47@186801|Clostridia,3WSKG@541000|Ruminococcaceae	186801|Clostridia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
DEZH2_k127_5715108_5	694427.Palpr_0995	2.238e-20	97.0	COG0576@1|root,COG0576@2|Bacteria,4NQ6M@976|Bacteroidetes,2FPIN@200643|Bacteroidia,22Y59@171551|Porphyromonadaceae	976|Bacteroidetes	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
DEZH2_k127_5715108_4	694427.Palpr_0644	2.261e-32	132.0	2985A@1|root,2ZVB7@2|Bacteria,4NNTB@976|Bacteroidetes,2FPUX@200643|Bacteroidia,22XX1@171551|Porphyromonadaceae	976|Bacteroidetes	S	Phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4494
DEZH2_k127_5715108_1	1122971.BAME01000175_gene6689	9.176e-72	248.0	2DKWN@1|root,30MJ5@2|Bacteria,4NPM6@976|Bacteroidetes,2FNBE@200643|Bacteroidia	976|Bacteroidetes	S	Protein of unknown function (DUF3164)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3164
DEZH2_k127_5715108_0	908937.Prede_2486	2.199e-77	263.0	COG0467@1|root,COG0467@2|Bacteria,4PKD7@976|Bacteroidetes,2G0TK@200643|Bacteroidia	976|Bacteroidetes	O	ATP-dependent serine protease	-	-	-	-	-	-	-	-	-	-	-	-	AAA
DEZH2_k127_5715108_2	927658.AJUM01000034_gene357	3.7e-49	177.0	COG2842@1|root,COG2842@2|Bacteria,4NNEH@976|Bacteroidetes,2FPX4@200643|Bacteroidia	976|Bacteroidetes	S	AAA domain	-	-	3.6.1.3	ko:K07132	-	-	-	-	ko00000,ko01000	-	-	-	AAA_22
DEZH2_k127_5721106_1	742741.HMPREF9475_03579	3.744e-60	210.0	COG1712@1|root,COG1712@2|Bacteria,1TQ4R@1239|Firmicutes,2499V@186801|Clostridia,21YPU@1506553|Lachnoclostridium	186801|Clostridia	E	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate	ddh	-	1.4.1.16	ko:K03340	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	M00526	R02755	RC00006	ko00000,ko00001,ko00002,ko01000	-	-	-	DAPDH_C,DapB_N
DEZH2_k127_5721106_0	1392491.JIAE01000001_gene1231	4.992e-220	709.0	COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia,3WGEC@541000|Ruminococcaceae	186801|Clostridia	L	HELICc2	dinG	-	3.1.12.1,3.6.4.12	ko:K07464,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400	-	-	-	DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1
DEZH2_k127_5721106_2	203119.Cthe_1066	7.75e-14	76.0	COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,249TI@186801|Clostridia,3WJ6A@541000|Ruminococcaceae	186801|Clostridia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
DEZH2_k127_5726193_1	398512.JQKC01000017_gene3098	3.544e-37	143.0	COG0575@1|root,COG0575@2|Bacteria,1V6V6@1239|Firmicutes,24KZJ@186801|Clostridia	186801|Clostridia	I	CDP-archaeol synthase	-	-	-	-	-	-	-	-	-	-	-	-	CarS-like
DEZH2_k127_5726193_0	398512.JQKC01000017_gene3097	1.173e-83	289.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia,3WI29@541000|Ruminococcaceae	186801|Clostridia	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DEZH2_k127_5747622_3	1392491.JIAE01000001_gene1386	1.245e-11	66.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,3WGPN@541000|Ruminococcaceae	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
DEZH2_k127_5747622_2	1392491.JIAE01000001_gene1387	2.328e-80	275.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,3WGTY@541000|Ruminococcaceae	186801|Clostridia	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
DEZH2_k127_5747622_0	1195236.CTER_4550	4.229e-159	511.0	COG0499@1|root,COG0499@2|Bacteria,1TQY0@1239|Firmicutes,248S3@186801|Clostridia,3WHN7@541000|Ruminococcaceae	186801|Clostridia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
DEZH2_k127_5747622_1	755731.Clo1100_2572	2.486e-89	310.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,36FIQ@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270	3.5.4.28,3.5.4.31,3.5.4.40	ko:K12960,ko:K20810	ko00130,ko00270,ko01100,ko01110,map00130,map00270,map01100,map01110	-	R09660,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
DEZH2_k127_5779822_0	1415775.U729_1256	3.84e-27	115.0	COG2088@1|root,COG2088@2|Bacteria,1V9ZG@1239|Firmicutes,24MVQ@186801|Clostridia,36JKP@31979|Clostridiaceae	186801|Clostridia	D	Could be involved in septation	spoVG	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
DEZH2_k127_5784275_0	86416.Clopa_0980	1.138e-48	184.0	COG4377@1|root,COG4377@2|Bacteria,1V3UF@1239|Firmicutes,24JI9@186801|Clostridia,36K76@31979|Clostridiaceae	186801|Clostridia	S	Putative membrane peptidase family (DUF2324)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2324
DEZH2_k127_5784275_1	1392491.JIAE01000001_gene930	1.788e-37	143.0	COG1695@1|root,COG1695@2|Bacteria,1VA8U@1239|Firmicutes,24NA9@186801|Clostridia,3WRW9@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
DEZH2_k127_5784275_4	1392491.JIAE01000001_gene931	1.243e-13	78.0	COG4709@1|root,COG4709@2|Bacteria	2|Bacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1700,DUF4097
DEZH2_k127_5784275_3	358681.BBR47_58260	1.2e-19	103.0	COG0457@1|root,COG2214@1|root,COG0457@2|Bacteria,COG2214@2|Bacteria,1V5Z5@1239|Firmicutes,4HH3V@91061|Bacilli,26U0Q@186822|Paenibacillaceae	91061|Bacilli	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
DEZH2_k127_5784275_2	243924.LT42_13110	1.83e-21	97.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_5847721_4	1292035.H476_1561	1.604e-33	131.0	COG0454@1|root,COG0454@2|Bacteria	2|Bacteria	K	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
DEZH2_k127_5847721_3	1105031.HMPREF1141_2341	1.188e-45	172.0	COG2153@1|root,COG2153@2|Bacteria,1VAJY@1239|Firmicutes,24JG3@186801|Clostridia,36JM2@31979|Clostridiaceae	186801|Clostridia	S	Acetyltransferase (GNAT) domain	-	-	-	ko:K02348	-	-	-	-	ko00000	-	-	-	Acetyltransf_10
DEZH2_k127_5847721_5	744872.Spica_2820	2.03e-11	72.0	2C6Z5@1|root,32RI1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5847721_2	994573.T472_0213285	5.419e-46	169.0	COG5646@1|root,COG5646@2|Bacteria,1VJMY@1239|Firmicutes	1239|Firmicutes	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
DEZH2_k127_5847721_1	573061.Clocel_3400	4.462e-79	270.0	COG0500@1|root,COG0789@1|root,COG0789@2|Bacteria,COG2226@2|Bacteria,1UI7M@1239|Firmicutes,24E0D@186801|Clostridia,36N6N@31979|Clostridiaceae	186801|Clostridia	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
DEZH2_k127_5847721_0	1123075.AUDP01000042_gene291	3.881e-122	400.0	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,24A5F@186801|Clostridia,3WQCQ@541000|Ruminococcaceae	186801|Clostridia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
DEZH2_k127_5849381_0	720554.Clocl_0907	1.109e-286	888.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,3WGGK@541000|Ruminococcaceae	186801|Clostridia	C	TIGRFAM formate acetyltransferase	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
DEZH2_k127_5849381_1	1158612.I580_01344	1.003e-40	163.0	COG4905@1|root,COG4905@2|Bacteria,1V2HX@1239|Firmicutes,4HMDB@91061|Bacilli,4B6KR@81852|Enterococcaceae	91061|Bacilli	S	Putative ABC-transporter type IV	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_CmpB
DEZH2_k127_5849381_6	1410632.JHWW01000011_gene2452	0.0004174	52.0	COG0860@1|root,COG0860@2|Bacteria,1UY5Q@1239|Firmicutes,247Y6@186801|Clostridia,27MBT@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3
DEZH2_k127_5849381_2	1507.HMPREF0262_02680	5.456e-21	101.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,36DE5@31979|Clostridiaceae	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
DEZH2_k127_5849381_3	318424.EU78_06215	1.128e-13	73.0	COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria,2386C@1762|Mycobacteriaceae	201174|Actinobacteria	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
DEZH2_k127_5853932_1	1211035.CD30_15120	8.442e-47	171.0	COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,4HASX@91061|Bacilli,3IX47@400634|Lysinibacillus	91061|Bacilli	E	Branched-chain-amino-acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iYO844.BSU38550	Aminotran_4
DEZH2_k127_5853932_2	1218076.BAYB01000004_gene730	2.295e-07	54.0	COG1396@1|root,COG1396@2|Bacteria,1NGM7@1224|Proteobacteria,2WHB6@28216|Betaproteobacteria,1KAXQ@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
DEZH2_k127_5853932_0	717605.Theco_1589	6.919e-72	255.0	COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,4HAPJ@91061|Bacilli,26TSR@186822|Paenibacillaceae	91061|Bacilli	S	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_5860555_2	1033737.CAEV01000086_gene123	1.675e-41	171.0	COG2898@1|root,COG2898@2|Bacteria,1U5FR@1239|Firmicutes,248XI@186801|Clostridia,36E5R@31979|Clostridiaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
DEZH2_k127_5860555_0	658086.HMPREF0994_01703	5.593e-150	484.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,27IHP@186928|unclassified Lachnospiraceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
DEZH2_k127_5860555_3	642492.Clole_1522	7.582e-40	158.0	298ZI@1|root,2ZW3A@2|Bacteria,1V7FU@1239|Firmicutes,24ID8@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K16788	-	-	-	-	ko00000,ko02000	2.A.88.5	-	-	ECF_trnsprt
DEZH2_k127_5860555_5	357809.Cphy_3059	2.448e-33	132.0	2CIJU@1|root,332RU@2|Bacteria,1VESI@1239|Firmicutes,24QR7@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF1893)	-	-	-	-	-	-	-	-	-	-	-	-	TM1506
DEZH2_k127_5860555_4	641107.CDLVIII_2698	7.283e-37	143.0	COG2315@1|root,COG2315@2|Bacteria,1V79C@1239|Firmicutes,24MUH@186801|Clostridia,36JS8@31979|Clostridiaceae	186801|Clostridia	L	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
DEZH2_k127_5860555_1	428125.CLOLEP_02857	8.166e-77	266.0	COG0451@1|root,COG0451@2|Bacteria,1TRTD@1239|Firmicutes,24AFT@186801|Clostridia,3WGHU@541000|Ruminococcaceae	186801|Clostridia	M	NAD dependent epimerase dehydratase family	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD,Epimerase
DEZH2_k127_5923733_4	1392491.JIAE01000001_gene1290	5.789e-66	228.0	COG0136@1|root,COG0136@2|Bacteria,1TPC6@1239|Firmicutes,248ZR@186801|Clostridia,3WGVU@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the aspartate-semialdehyde dehydrogenase family	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DEZH2_k127_5923733_6	509191.AEDB02000003_gene1019	8.812e-10	59.0	2DPV4@1|root,333HA@2|Bacteria,1VH7Z@1239|Firmicutes,24SC2@186801|Clostridia,3WQ8C@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5923733_3	1392491.JIAE01000001_gene1395	6.545e-70	241.0	COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,24FQD@186801|Clostridia,3WIVY@541000|Ruminococcaceae	186801|Clostridia	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	iHN637.CLJU_RS05275	Pribosyltran
DEZH2_k127_5923733_1	1392491.JIAE01000001_gene1396	2.98e-149	477.0	COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia,3WG83@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N,PyrI_C
DEZH2_k127_5923733_0	1410638.JHXJ01000013_gene2348	2.889e-167	536.0	COG0044@1|root,COG0044@2|Bacteria,1TPQM@1239|Firmicutes,247V2@186801|Clostridia,3WGV4@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
DEZH2_k127_5923733_2	1121335.Clst_2005	1.882e-100	336.0	COG0284@1|root,COG0284@2|Bacteria,1TQ7P@1239|Firmicutes,247SZ@186801|Clostridia,3WH6X@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17585	OMPdecase
DEZH2_k127_5923733_5	1392491.JIAE01000001_gene1399	1.921e-31	127.0	COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,3WGW1@541000|Ruminococcaceae	186801|Clostridia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
DEZH2_k127_5944990_0	1120746.CCNL01000005_gene106	2.771e-123	405.0	COG0446@1|root,COG0446@2|Bacteria,2NP2E@2323|unclassified Bacteria	2|Bacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_3
DEZH2_k127_5944990_2	518637.EUBIFOR_01554	1.716e-25	112.0	COG3862@1|root,COG3862@2|Bacteria,1VA4U@1239|Firmicutes,3VRK6@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Protein of unknown function (DUF1667)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1667
DEZH2_k127_5944990_3	476272.RUMHYD_00760	3.806e-15	80.0	COG2456@1|root,COG2456@2|Bacteria,1VGMQ@1239|Firmicutes,24NPY@186801|Clostridia,3Y0U7@572511|Blautia	186801|Clostridia	S	Uncharacterized conserved protein (DUF2304)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2304
DEZH2_k127_5944990_1	478749.BRYFOR_07383	5.569e-35	136.0	COG1216@1|root,COG1216@2|Bacteria,1TS11@1239|Firmicutes,24BQ6@186801|Clostridia	186801|Clostridia	S	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721,ko:K00786	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
DEZH2_k127_5947002_0	1469948.JPNB01000003_gene90	3.785e-60	226.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,36EYT@31979|Clostridiaceae	186801|Clostridia	G	Glycosyltransferase 36 associated	ndvB	-	-	-	-	-	-	-	-	-	-	-	DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase
DEZH2_k127_5958475_1	1410608.JNKX01000016_gene2494	1.83e-17	94.0	COG5263@1|root,COG5263@2|Bacteria,4NJ6B@976|Bacteroidetes,2FU00@200643|Bacteroidia,4AS6J@815|Bacteroidaceae	976|Bacteroidetes	S	WG containing repeat	-	-	-	-	-	-	-	-	-	-	-	-	WG_beta_rep
DEZH2_k127_5958475_0	1443665.JACA01000072_gene1858	1.328e-33	146.0	COG0823@1|root,COG0823@2|Bacteria,4PI4J@976|Bacteroidetes,1II35@117743|Flavobacteriia,2YKPX@290174|Aquimarina	976|Bacteroidetes	U	Domain of unknown function (DUF5050)	-	-	-	-	-	-	-	-	-	-	-	-	PD40
DEZH2_k127_5958827_13	1473546.CH76_00770	1.26e-14	79.0	COG1358@1|root,COG1358@2|Bacteria,1VEYG@1239|Firmicutes,4HNY7@91061|Bacilli,3IY7P@400634|Lysinibacillus	91061|Bacilli	J	50S ribosomal protein L7	ylxQ	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_L7Ae
DEZH2_k127_5958827_11	1120985.AUMI01000020_gene1217	1.394e-22	99.0	COG2740@1|root,COG2740@2|Bacteria,1VEJS@1239|Firmicutes,4H5KD@909932|Negativicutes	909932|Negativicutes	K	Protein of unknown function (DUF448)	ylxR	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
DEZH2_k127_5958827_1	1392491.JIAE01000001_gene920	1.607e-129	427.0	COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia,3WG8A@541000|Ruminococcaceae	186801|Clostridia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
DEZH2_k127_5958827_6	1392491.JIAE01000001_gene919	5.517e-43	162.0	COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,24N1G@186801|Clostridia,3WJSY@541000|Ruminococcaceae	186801|Clostridia	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
DEZH2_k127_5958827_7	1392491.JIAE01000001_gene918	8.074e-43	160.0	COG0433@1|root,COG0433@2|Bacteria,1VF8X@1239|Firmicutes,24N9T@186801|Clostridia,3WJSW@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5958827_9	1442599.JAAN01000014_gene3295	2.312e-36	142.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,1X701@135614|Xanthomonadales	135614|Xanthomonadales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
DEZH2_k127_5958827_5	398512.JQKC01000001_gene2483	1.295e-52	191.0	COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia,3WJ0F@541000|Ruminococcaceae	186801|Clostridia	E	Acetolactate synthase small	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
DEZH2_k127_5958827_0	1120998.AUFC01000035_gene1270	6.003e-158	504.0	COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,247RH@186801|Clostridia,3WCSR@538999|Clostridiales incertae sedis	186801|Clostridia	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
DEZH2_k127_5958827_8	1282887.AUJG01000015_gene744	1.051e-39	151.0	COG2033@1|root,COG2033@2|Bacteria,1VA34@1239|Firmicutes,24J9I@186801|Clostridia	186801|Clostridia	C	Desulfoferrodoxin ferrous iron-binding	rbo	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
DEZH2_k127_5958827_4	1392491.JIAE01000001_gene916	1.355e-79	269.0	COG1592@1|root,COG1592@2|Bacteria,1V1FF@1239|Firmicutes,248V2@186801|Clostridia,3WIE3@541000|Ruminococcaceae	186801|Clostridia	C	Rubrerythrin	rbr	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DEZH2_k127_5958827_10	1408439.JHXW01000009_gene390	6.577e-30	123.0	COG0735@1|root,COG0735@2|Bacteria,37ADT@32066|Fusobacteria	32066|Fusobacteria	P	Belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
DEZH2_k127_5958827_12	1410653.JHVC01000009_gene2676	1.716e-18	92.0	COG0640@1|root,COG0640@2|Bacteria,1VEER@1239|Firmicutes,24QZK@186801|Clostridia,36JJV@31979|Clostridiaceae	186801|Clostridia	K	regulatory protein, arsR	arsR	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
DEZH2_k127_5958827_3	1392491.JIAE01000001_gene912	4.149e-92	306.0	COG0789@1|root,COG0789@2|Bacteria,1UYCQ@1239|Firmicutes,24ICJ@186801|Clostridia,3WM6F@541000|Ruminococcaceae	186801|Clostridia	K	Protein of unknown function (DUF4004)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4004
DEZH2_k127_5958827_15	1280673.AUJJ01000022_gene2858	0.0004914	50.0	29VU3@1|root,30HBR@2|Bacteria,1UHEU@1239|Firmicutes,25Q5U@186801|Clostridia,4C051@830|Butyrivibrio	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5958827_2	1392491.JIAE01000001_gene1942	6.454e-103	370.0	28YI5@1|root,2ZKC3@2|Bacteria,1W58K@1239|Firmicutes,2557E@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5986472_3	1392491.JIAE01000001_gene1353	2.014e-11	68.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,257WZ@186801|Clostridia,3WK6A@541000|Ruminococcaceae	186801|Clostridia	EH	Amino-transferase class IV	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_4
DEZH2_k127_5986472_0	1392491.JIAE01000001_gene1348	1.872e-224	700.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,3WGG9@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
DEZH2_k127_5986472_1	1392491.JIAE01000001_gene1346	2.086e-199	630.0	COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia,3WGBU@541000|Ruminococcaceae	186801|Clostridia	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
DEZH2_k127_5986472_2	857087.Metme_0864	1.024e-16	92.0	COG0457@1|root,COG4976@1|root,COG0457@2|Bacteria,COG4976@2|Bacteria,1RAIT@1224|Proteobacteria,1S6MW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	methyltransferase	yrrB	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31,TPR_1,TPR_16,TPR_2,TPR_4,TPR_7,TPR_8
DEZH2_k127_5986829_1	203119.Cthe_0379	2.333e-102	340.0	28PUB@1|root,2ZCFC@2|Bacteria,1V31D@1239|Firmicutes,24H5U@186801|Clostridia,3WNQF@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_5986829_2	1163671.JAGI01000002_gene3973	2.127e-68	240.0	COG4753@1|root,COG4753@2|Bacteria,1URF2@1239|Firmicutes,24FGY@186801|Clostridia,36GPE@31979|Clostridiaceae	186801|Clostridia	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC,Response_reg
DEZH2_k127_5986829_0	428125.CLOLEP_00467	4.719e-126	424.0	COG2972@1|root,COG2972@2|Bacteria,1TS61@1239|Firmicutes,247ZZ@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
DEZH2_k127_5986829_3	428125.CLOLEP_00464	3.041e-53	194.0	COG1653@1|root,COG1653@2|Bacteria,1TRMK@1239|Firmicutes,24BMJ@186801|Clostridia,3WRSW@541000|Ruminococcaceae	186801|Clostridia	G	COG COG1653 ABC-type sugar transport system, periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
DEZH2_k127_6054054_2	1160707.AJIK01000003_gene773	3.234e-134	434.0	COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,4HASX@91061|Bacilli,26E1B@186818|Planococcaceae	91061|Bacilli	E	Amino-transferase class IV	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iYO844.BSU38550	Aminotran_4
DEZH2_k127_6054054_1	1392491.JIAE01000001_gene2015	4.306e-287	896.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,3WGH5@541000|Ruminococcaceae	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
DEZH2_k127_6054054_0	720554.Clocl_2233	0.0	1178.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,3WGNQ@541000|Ruminococcaceae	186801|Clostridia	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
DEZH2_k127_6073810_2	1195236.CTER_2708	7.698e-51	182.0	COG3411@1|root,COG3411@2|Bacteria,1VCJG@1239|Firmicutes,24JC4@186801|Clostridia,3WJKB@541000|Ruminococcaceae	186801|Clostridia	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx,DUF1636
DEZH2_k127_6073810_0	1195236.CTER_2707	0.0	1071.0	COG0535@1|root,COG2710@1|root,COG0535@2|Bacteria,COG2710@2|Bacteria,1TQGZ@1239|Firmicutes,249AD@186801|Clostridia,3WHGX@541000|Ruminococcaceae	186801|Clostridia	C	Nitrogenase cofactor biosynthesis protein NifB	nifB	-	-	ko:K02585,ko:K02592	-	-	-	-	ko00000	-	-	-	Fer4_14,Nitro_FeMo-Co,Oxidored_nitro,Radical_SAM
DEZH2_k127_6073810_1	1195236.CTER_2706	1.114e-191	604.0	COG2710@1|root,COG2710@2|Bacteria,1TT07@1239|Firmicutes,248NS@186801|Clostridia,3WGTM@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the NifD NifK NifE NifN family	nifE	-	-	ko:K02587	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
DEZH2_k127_6094454_3	1120746.CCNL01000010_gene1145	8.441e-45	164.0	COG1132@1|root,COG1132@2|Bacteria,2NP2M@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DEZH2_k127_6094454_0	1120746.CCNL01000010_gene1146	5.319e-276	861.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DEZH2_k127_6094454_4	509191.AEDB02000098_gene3519	4.898e-24	102.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia,3WKG4@541000|Ruminococcaceae	186801|Clostridia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
DEZH2_k127_6094454_1	357809.Cphy_3001	1.839e-198	626.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,21XMD@1506553|Lachnoclostridium	186801|Clostridia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
DEZH2_k127_6094454_2	1196029.ALIM01000014_gene3835	4.073e-116	383.0	COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,4HB1D@91061|Bacilli,1ZB3C@1386|Bacillus	91061|Bacilli	G	Belongs to the glycosyl hydrolase 31 family	yicI	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
DEZH2_k127_6174033_1	880072.Desac_1272	1.435e-05	58.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GAF_2,GGDEF,PAS_3,Response_reg,Y_Y_Y
DEZH2_k127_6174033_0	203119.Cthe_0256	2.426e-41	172.0	COG1609@1|root,COG4191@1|root,COG1609@2|Bacteria,COG4191@2|Bacteria,1UITR@1239|Firmicutes,25ER9@186801|Clostridia,3WSI7@541000|Ruminococcaceae	186801|Clostridia	KT	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Peripla_BP_3
DEZH2_k127_6182259_3	1280666.ATVS01000002_gene3028	3.224e-58	217.0	COG2755@1|root,COG2755@2|Bacteria,1TSSA@1239|Firmicutes,24EZX@186801|Clostridia,4BX5V@830|Butyrivibrio	186801|Clostridia	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
DEZH2_k127_6182259_0	509191.AEDB02000022_gene2984	9.422e-94	314.0	COG0433@1|root,COG0433@2|Bacteria,1TR1F@1239|Firmicutes,24BT8@186801|Clostridia,3WHQ5@541000|Ruminococcaceae	186801|Clostridia	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
DEZH2_k127_6182259_2	1280941.HY2_00555	1.887e-73	254.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2TRU8@28211|Alphaproteobacteria,43WH4@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
DEZH2_k127_6182259_1	1121335.Clst_0125	4.893e-80	278.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,3WGDN@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
DEZH2_k127_6182259_4	411489.CLOL250_00363	1.012e-19	93.0	COG0671@1|root,COG0671@2|Bacteria,1VB7J@1239|Firmicutes,24JDD@186801|Clostridia,36JV0@31979|Clostridiaceae	186801|Clostridia	I	Membrane-associated phospholipid phosphatase	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
DEZH2_k127_6184041_2	1392491.JIAE01000001_gene1998	2.22e-62	219.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,3WGBM@541000|Ruminococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
DEZH2_k127_6184041_4	699246.HMPREF0868_0051	9.818e-21	94.0	COG1314@1|root,COG1314@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
DEZH2_k127_6184041_0	1392491.JIAE01000001_gene1995	6.499e-191	617.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,3WGHJ@541000|Ruminococcaceae	186801|Clostridia	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
DEZH2_k127_6184041_3	203119.Cthe_0149	1.517e-22	99.0	COG1925@1|root,COG1925@2|Bacteria,1VAQP@1239|Firmicutes,24N19@186801|Clostridia,3WKEN@541000|Ruminococcaceae	186801|Clostridia	G	PTS HPr component phosphorylation site	-	-	-	-	-	-	-	-	-	-	-	-	PTS-HPr
DEZH2_k127_6184041_1	1392491.JIAE01000001_gene1950	1.074e-96	327.0	COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,3WG80@541000|Ruminococcaceae	186801|Clostridia	J	tRNA methylthiotransferase YqeV	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
DEZH2_k127_6241044_0	1392491.JIAE01000001_gene1260	2.13e-69	249.0	COG0350@1|root,COG0350@2|Bacteria,1VA03@1239|Firmicutes,24JAA@186801|Clostridia,3WS5T@541000|Ruminococcaceae	186801|Clostridia	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
DEZH2_k127_6241044_1	1392491.JIAE01000001_gene1261	1.521e-58	207.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,3WIF0@541000|Ruminococcaceae	186801|Clostridia	S	Flavin reductase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
DEZH2_k127_6256766_1	1131462.DCF50_p745	4.549e-92	306.0	COG1653@1|root,COG1653@2|Bacteria,1V0YN@1239|Firmicutes	1239|Firmicutes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
DEZH2_k127_6256766_0	931626.Awo_c04280	3.45e-143	462.0	COG3437@1|root,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,25V1R@186806|Eubacteriaceae	186801|Clostridia	T	Psort location Cytoplasmic, score	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,PAS_3,Response_reg
DEZH2_k127_6256766_2	1123288.SOV_3c08100	3.944e-54	195.0	COG0642@1|root,COG0834@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,4H30J@909932|Negativicutes	909932|Negativicutes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,HATPase_c,HisKA,Hpt,PAS_8,Response_reg
DEZH2_k127_6260813_4	742738.HMPREF9460_02924	1.038e-72	258.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia,268XC@186813|unclassified Clostridiales	186801|Clostridia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
DEZH2_k127_6260813_10	35841.BT1A1_1667	1.256e-12	74.0	COG5341@1|root,COG5341@2|Bacteria,1VCR8@1239|Firmicutes,4HKP0@91061|Bacilli,1ZIM5@1386|Bacillus	91061|Bacilli	S	NusG domain II	-	-	-	-	-	-	-	-	-	-	-	-	NusG_II
DEZH2_k127_6260813_6	1226322.HMPREF1545_01682	1.904e-27	119.0	COG4769@1|root,COG4769@2|Bacteria,1V1M0@1239|Firmicutes,24MZC@186801|Clostridia,2N7AA@216572|Oscillospiraceae	186801|Clostridia	S	Heptaprenyl diphosphate synthase component I	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
DEZH2_k127_6260813_7	1121468.AUBR01000010_gene2431	3.978e-26	118.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,42EWB@68295|Thermoanaerobacterales	186801|Clostridia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	ACPS,Carb_kinase,YjeF_N
DEZH2_k127_6260813_8	411474.COPEUT_01230	1.436e-21	100.0	COG1853@1|root,COG1853@2|Bacteria,1V7DF@1239|Firmicutes,24G44@186801|Clostridia	186801|Clostridia	C	rubredoxin	hrb	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Rubredoxin
DEZH2_k127_6260813_1	642492.Clole_2223	2.597e-132	430.0	COG1052@1|root,COG1052@2|Bacteria,1TSZ6@1239|Firmicutes,249PP@186801|Clostridia	186801|Clostridia	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	ldhA	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C,PTS-HPr
DEZH2_k127_6260813_0	693746.OBV_08860	1.984e-272	846.0	COG0369@1|root,COG1151@2|Bacteria,1TP8X@1239|Firmicutes,247IN@186801|Clostridia,2N6J5@216572|Oscillospiraceae	186801|Clostridia	P	Prismane/CO dehydrogenase family	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
DEZH2_k127_6260813_3	1121344.JHZO01000001_gene609	1.322e-97	324.0	COG1145@1|root,COG1145@2|Bacteria,1TPAZ@1239|Firmicutes,249NJ@186801|Clostridia,3WGU7@541000|Ruminococcaceae	186801|Clostridia	C	4Fe-4S binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
DEZH2_k127_6260813_5	663278.Ethha_1746	3.214e-51	189.0	COG0664@1|root,COG0664@2|Bacteria,1TSP9@1239|Firmicutes,24FRD@186801|Clostridia,3WPDK@541000|Ruminococcaceae	186801|Clostridia	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
DEZH2_k127_6260813_9	1114970.PSF113_1046	3.691e-18	99.0	COG0457@1|root,COG0457@2|Bacteria,1RBMC@1224|Proteobacteria,1S33Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6260813_2	324057.Pjdr2_2890	2.379e-108	364.0	COG0488@1|root,COG0488@2|Bacteria,1TQNA@1239|Firmicutes,4H9VW@91061|Bacilli,26WIK@186822|Paenibacillaceae	91061|Bacilli	S	ABC transporter	expZ	-	-	ko:K18231	ko02010,map02010	-	-	-	br01600,ko00000,ko00001,ko01504,ko02000	3.A.1.121.1,3.A.1.121.3	-	-	ABC_tran,ABC_tran_Xtn
DEZH2_k127_6263987_1	509191.AEDB02000016_gene12	2.503e-104	344.0	COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,248DH@186801|Clostridia,3WH12@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the LDH MDH superfamily. LDH family	ldh	-	1.1.1.27	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	-	R00703,R01000,R03104	RC00031,RC00044	ko00000,ko00001,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
DEZH2_k127_6263987_2	1174504.AJTN02000193_gene4085	3.703e-101	342.0	COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,4HARP@91061|Bacilli,1ZC9P@1386|Bacillus	91061|Bacilli	G	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)	galK	GO:0005975,GO:0005996,GO:0006012,GO:0008150,GO:0008152,GO:0019318,GO:0044238,GO:0044281,GO:0071704	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
DEZH2_k127_6263987_3	1392491.JIAE01000001_gene2532	5.241e-86	302.0	COG1686@1|root,COG1686@2|Bacteria,1TU06@1239|Firmicutes,25B23@186801|Clostridia	186801|Clostridia	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
DEZH2_k127_6263987_4	699246.HMPREF0868_1289	1.348e-45	171.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,267YZ@186813|unclassified Clostridiales	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
DEZH2_k127_6263987_0	1392491.JIAE01000001_gene2533	2.919e-203	642.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,3WGW0@541000|Ruminococcaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
DEZH2_k127_6283479_4	1121342.AUCO01000002_gene897	0.0001442	51.0	COG0457@1|root,COG0457@2|Bacteria,1UKYH@1239|Firmicutes,24B57@186801|Clostridia,36FBV@31979|Clostridiaceae	186801|Clostridia	O	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_12,TPR_16,TPR_19,TPR_2,TPR_8
DEZH2_k127_6283479_0	1121334.KB911066_gene831	1.549e-94	315.0	COG1179@1|root,COG1179@2|Bacteria,1TQ7A@1239|Firmicutes,248RA@186801|Clostridia,3WG8S@541000|Ruminococcaceae	186801|Clostridia	H	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1	thiF	-	-	ko:K22132	-	-	-	-	ko00000,ko03016	-	-	-	ThiF
DEZH2_k127_6283479_2	1292035.H476_0791	5.191e-63	224.0	COG0745@1|root,COG0745@2|Bacteria,1TYPK@1239|Firmicutes,247Y9@186801|Clostridia,25SKP@186804|Peptostreptococcaceae	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07668	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_6283479_1	536233.CLO_1935	4.583e-75	270.0	COG0642@1|root,COG2205@2|Bacteria,1TS12@1239|Firmicutes,24AAW@186801|Clostridia,36F9J@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
DEZH2_k127_6283479_3	1095770.CAHE01000059_gene1567	1.551e-09	61.0	2EF5D@1|root,338YJ@2|Bacteria,1VI9N@1239|Firmicutes,255U4@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_634121_0	588581.Cpap_3544	2.018e-77	271.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,3WHIU@541000|Ruminococcaceae	186801|Clostridia	K	Psort location Cytoplasmic, score	scrR	-	5.1.1.1	ko:K01775,ko:K02529,ko:K03484	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
DEZH2_k127_6341981_2	1392491.JIAE01000001_gene1740	1.658e-43	171.0	COG0860@1|root,COG0860@2|Bacteria,1UY5Q@1239|Firmicutes,247Y6@186801|Clostridia,3WITB@541000|Ruminococcaceae	186801|Clostridia	M	N-acetylmuramoyl-L-alanine amidase	lytC_3	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3
DEZH2_k127_6341981_1	931626.Awo_c33250	1.781e-65	226.0	2DH26@1|root,2ZY4Z@2|Bacteria,1V3J9@1239|Firmicutes,24HRK@186801|Clostridia,25ZM9@186806|Eubacteriaceae	186801|Clostridia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
DEZH2_k127_6341981_0	357809.Cphy_0263	3.484e-184	589.0	COG2304@1|root,COG2304@2|Bacteria,1TSU7@1239|Firmicutes,249KV@186801|Clostridia,221XM@1506553|Lachnoclostridium	186801|Clostridia	S	Domain of unknown function (DUF3520)	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
DEZH2_k127_6341981_3	68260.JOAY01000004_gene4634	0.0001091	49.0	COG0845@1|root,COG0845@2|Bacteria,2H154@201174|Actinobacteria	201174|Actinobacteria	M	Efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
DEZH2_k127_6346810_1	646529.Desaci_1271	3.494e-175	557.0	COG2206@1|root,COG2206@2|Bacteria,1TS2E@1239|Firmicutes,249S8@186801|Clostridia,260HU@186807|Peptococcaceae	186801|Clostridia	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
DEZH2_k127_6346810_0	635013.TherJR_0169	1.539e-231	722.0	COG1373@1|root,COG1373@2|Bacteria,1TQ8Z@1239|Firmicutes,24A83@186801|Clostridia,2606C@186807|Peptococcaceae	186801|Clostridia	S	AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
DEZH2_k127_6346810_2	138119.DSY1483	1.293e-32	128.0	COG3077@1|root,COG3077@2|Bacteria,1VEDW@1239|Firmicutes,24QJN@186801|Clostridia,2661I@186807|Peptococcaceae	186801|Clostridia	L	RelB antitoxin	-	-	-	ko:K07473	-	-	-	-	ko00000,ko02048	-	-	-	RelB
DEZH2_k127_6346810_3	1345695.CLSA_c36800	2.467e-13	70.0	COG0454@1|root,COG0456@2|Bacteria,1VFYP@1239|Firmicutes,24HHZ@186801|Clostridia,36IYM@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,Acetyltransf_7
DEZH2_k127_6380690_0	1392491.JIAE01000001_gene99	0.0	1083.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,3WGZ0@541000|Ruminococcaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
DEZH2_k127_6380690_2	1392491.JIAE01000001_gene97	2.179e-98	334.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia,3WHXU@541000|Ruminococcaceae	186801|Clostridia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
DEZH2_k127_6380690_1	1392491.JIAE01000001_gene96	1.042e-132	432.0	COG0592@1|root,COG0592@2|Bacteria,1TQ7J@1239|Firmicutes,248EG@186801|Clostridia,3WGZ2@541000|Ruminococcaceae	186801|Clostridia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
DEZH2_k127_6471805_2	509191.AEDB02000022_gene3011	3.226e-20	95.0	arCOG03165@1|root,30AIC@2|Bacteria,1V7NB@1239|Firmicutes,24M5X@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6471805_0	1128398.Curi_c23290	1.563e-111	370.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,2682T@186813|unclassified Clostridiales	186801|Clostridia	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
DEZH2_k127_6471805_1	658086.HMPREF0994_07216	2.979e-46	171.0	COG3250@1|root,COG3250@2|Bacteria,1TSMY@1239|Firmicutes,24B54@186801|Clostridia,27KNP@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Protein of unknown function (DUF2804)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2804
DEZH2_k127_6492130_4	697303.Thewi_1823	1.347e-36	153.0	COG3437@1|root,COG5002@1|root,COG3437@2|Bacteria,COG5002@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia,42JG8@68295|Thermoanaerobacterales	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5,PAS,PAS_4,PAS_9,SBP_bac_3
DEZH2_k127_6492130_5	1410633.JHWR01000001_gene1287	1.013e-26	117.0	COG0500@1|root,COG2226@2|Bacteria,1UWA7@1239|Firmicutes,24WBZ@186801|Clostridia,27TE2@186928|unclassified Lachnospiraceae	186801|Clostridia	Q	Putative methyltransferase	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
DEZH2_k127_6492130_2	720554.Clocl_3553	5.336e-66	229.0	COG2059@1|root,COG2059@2|Bacteria,1V42U@1239|Firmicutes,24HA0@186801|Clostridia,3WJYR@541000|Ruminococcaceae	186801|Clostridia	P	Psort location CytoplasmicMembrane, score	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
DEZH2_k127_6492130_3	1499684.CCNP01000023_gene3154	5.937e-63	222.0	COG2059@1|root,COG2059@2|Bacteria,1V22C@1239|Firmicutes,24G7P@186801|Clostridia,36FDX@31979|Clostridiaceae	186801|Clostridia	P	overlaps another CDS with the same product name	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
DEZH2_k127_6492130_0	1121344.JHZO01000001_gene397	4.405e-145	467.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,3WGZU@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
DEZH2_k127_6492130_1	1514668.JOOA01000002_gene968	2.395e-139	448.0	COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,247IJ@186801|Clostridia,3WGEP@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12020	NadA
DEZH2_k127_6492130_6	1291050.JAGE01000001_gene1372	1.049e-21	94.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,3WG9Z@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DEZH2_k127_6512960_3	1392491.JIAE01000001_gene1536	2.488e-77	265.0	COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,249VW@186801|Clostridia,3WJM6@541000|Ruminococcaceae	186801|Clostridia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
DEZH2_k127_6512960_1	509191.AEDB02000003_gene1094	3.228e-149	479.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia,3WGS4@541000|Ruminococcaceae	186801|Clostridia	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
DEZH2_k127_6512960_7	1410638.JHXJ01000002_gene1381	2.781e-38	153.0	COG1994@1|root,COG1994@2|Bacteria,1V6D4@1239|Firmicutes,24K0D@186801|Clostridia,3WJN0@541000|Ruminococcaceae	186801|Clostridia	S	peptidase M50	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
DEZH2_k127_6512960_4	1392491.JIAE01000001_gene1538	1.201e-75	260.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,3WG9B@541000|Ruminococcaceae	186801|Clostridia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
DEZH2_k127_6512960_0	1392491.JIAE01000001_gene1538	0.0	1244.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,3WG9B@541000|Ruminococcaceae	186801|Clostridia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
DEZH2_k127_6512960_5	1392491.JIAE01000001_gene1539	2.517e-71	246.0	COG3481@1|root,COG3481@2|Bacteria,1TQEK@1239|Firmicutes,24BRR@186801|Clostridia,3WIKZ@541000|Ruminococcaceae	186801|Clostridia	S	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
DEZH2_k127_6512960_6	1392491.JIAE01000001_gene1540	1.161e-68	240.0	COG0564@1|root,COG0564@2|Bacteria,1TX59@1239|Firmicutes,24HTV@186801|Clostridia,3WHF8@541000|Ruminococcaceae	186801|Clostridia	J	Pseudouridine synthase	rluC	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
DEZH2_k127_6512960_2	1410638.JHXJ01000002_gene1378	4.355e-116	381.0	COG1092@1|root,COG1092@2|Bacteria,1TPUD@1239|Firmicutes,2480X@186801|Clostridia,3WGYH@541000|Ruminococcaceae	186801|Clostridia	J	S-adenosylmethionine-dependent methyltransferase	rlmL_1	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
DEZH2_k127_6516454_1	1392491.JIAE01000001_gene1379	3.076e-104	339.0	COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,3WGWV@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
DEZH2_k127_6516454_0	97138.C820_02637	1.463e-229	736.0	COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,36DSY@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
DEZH2_k127_6522526_6	324602.Caur_3881	2.608e-23	105.0	COG1680@1|root,COG1680@2|Bacteria,2G7A9@200795|Chloroflexi,376UD@32061|Chloroflexia	32061|Chloroflexia	V	PFAM beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
DEZH2_k127_6522526_5	431943.CKL_0529	2.137e-36	144.0	COG3279@1|root,COG3279@2|Bacteria,1VISU@1239|Firmicutes,25BBX@186801|Clostridia,36GST@31979|Clostridiaceae	186801|Clostridia	K	PFAM LytTr DNA-binding region	-	-	-	-	-	-	-	-	-	-	-	-	LytTR
DEZH2_k127_6522526_2	1123376.AUIU01000017_gene90	8.957e-64	221.0	COG0394@1|root,COG0394@2|Bacteria	2|Bacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
DEZH2_k127_6522526_0	1123376.AUIU01000017_gene94	4.448e-190	599.0	COG0798@1|root,COG0798@2|Bacteria,3J0XN@40117|Nitrospirae	40117|Nitrospirae	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
DEZH2_k127_6522526_3	994573.T472_0219110	3.624e-60	214.0	COG0701@1|root,COG0701@2|Bacteria,1V49V@1239|Firmicutes,24FRM@186801|Clostridia,36I1P@31979|Clostridiaceae	186801|Clostridia	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
DEZH2_k127_6522526_1	1123009.AUID01000016_gene14	1.883e-65	228.0	COG0701@1|root,COG0701@2|Bacteria,1V5T4@1239|Firmicutes,24HM7@186801|Clostridia,26BSM@186813|unclassified Clostridiales	186801|Clostridia	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
DEZH2_k127_6522526_4	663278.Ethha_1885	4.789e-53	189.0	COG0526@1|root,COG0526@2|Bacteria,1VEYC@1239|Firmicutes,24QMF@186801|Clostridia,3WKWC@541000|Ruminococcaceae	186801|Clostridia	CO	redox-active disulfide protein 2	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
DEZH2_k127_6535648_1	699246.HMPREF0868_0866	2.073e-120	396.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,267WA@186813|unclassified Clostridiales	186801|Clostridia	C	4Fe-4S single cluster domain	scfB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
DEZH2_k127_6535648_3	1410638.JHXJ01000002_gene1406	5.109e-22	99.0	COG1862@1|root,COG1862@2|Bacteria,1VEMC@1239|Firmicutes,24MMT@186801|Clostridia,3WKMJ@541000|Ruminococcaceae	186801|Clostridia	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
DEZH2_k127_6535648_2	428125.CLOLEP_02857	4.728e-112	370.0	COG0451@1|root,COG0451@2|Bacteria,1TRTD@1239|Firmicutes,24AFT@186801|Clostridia,3WGHU@541000|Ruminococcaceae	186801|Clostridia	M	NAD dependent epimerase dehydratase family	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD,Epimerase
DEZH2_k127_6535648_0	1392491.JIAE01000001_gene1507	4.135e-172	544.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,3WGAU@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
DEZH2_k127_653745_1	1392491.JIAE01000001_gene575	4.209e-39	150.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,3WJJ8@541000|Ruminococcaceae	186801|Clostridia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
DEZH2_k127_653745_0	720554.Clocl_3842	5.187e-114	381.0	COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia,3WGRH@541000|Ruminococcaceae	186801|Clostridia	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
DEZH2_k127_6551968_3	1410638.JHXJ01000002_gene1285	1.748e-44	163.0	COG0136@1|root,COG0136@2|Bacteria,1TPC6@1239|Firmicutes,248ZR@186801|Clostridia,3WGVU@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the aspartate-semialdehyde dehydrogenase family	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DEZH2_k127_6551968_2	1410638.JHXJ01000002_gene1282	1.115e-112	372.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,3WGCI@541000|Ruminococcaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
DEZH2_k127_6551968_1	203119.Cthe_1795	2.666e-138	447.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,3WG9J@541000|Ruminococcaceae	186801|Clostridia	E	synthase	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
DEZH2_k127_6551968_0	1392491.JIAE01000001_gene1274	7.095e-205	648.0	COG1362@1|root,COG1362@2|Bacteria,1TP6G@1239|Firmicutes,2486Y@186801|Clostridia,3WHAH@541000|Ruminococcaceae	186801|Clostridia	E	M18 family aminopeptidase	apeA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M18
DEZH2_k127_6551968_4	1410638.JHXJ01000002_gene1432	4.044e-06	51.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,3WHRZ@541000|Ruminococcaceae	186801|Clostridia	E	histidinol phosphate phosphatase HisJ family	hisK	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
DEZH2_k127_6570121_0	1392491.JIAE01000001_gene1769	7.73e-68	254.0	COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia,3WG8U@541000|Ruminococcaceae	186801|Clostridia	L	ATP-dependent helicase deoxyribonuclease subunit B	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
DEZH2_k127_66176_0	272558.10173619	3.747e-138	452.0	COG3559@1|root,COG3559@2|Bacteria,1TPIG@1239|Firmicutes,4H9SK@91061|Bacilli,1ZC4C@1386|Bacillus	91061|Bacilli	M	Exporter of polyketide antibiotics	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
DEZH2_k127_6646457_1	742738.HMPREF9460_03544	1.081e-127	417.0	COG1674@1|root,COG1674@2|Bacteria,1UYYW@1239|Firmicutes,24EN0@186801|Clostridia	186801|Clostridia	D	FtsK/SpoIIIE family	-	-	-	-	-	-	-	-	-	-	-	-	FtsK_SpoIIIE
DEZH2_k127_6646457_2	1235800.C819_04132	1.14e-25	108.0	2E38H@1|root,32Y87@2|Bacteria,1VIF1@1239|Firmicutes,24RTS@186801|Clostridia,27Q0I@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Excisionase from transposon Tn916	-	-	-	-	-	-	-	-	-	-	-	-	Tn916-Xis
DEZH2_k127_6646457_0	796945.HMPREF1145_1824	2.81e-199	627.0	COG0582@1|root,COG0582@2|Bacteria,1TPCB@1239|Firmicutes,2485Y@186801|Clostridia,2PRXW@265975|Oribacterium	186801|Clostridia	L	DNA binding domain of tn916 integrase	-	-	-	-	-	-	-	-	-	-	-	-	Integrase_DNA,Phage_int_SAM_3,Phage_integrase
DEZH2_k127_6669762_0	1392491.JIAE01000001_gene1174	3.294e-84	284.0	COG0726@1|root,COG0726@2|Bacteria,1TWQ0@1239|Firmicutes,24BEF@186801|Clostridia,3WI2D@541000|Ruminococcaceae	186801|Clostridia	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
DEZH2_k127_6669762_3	431943.CKL_2170	1.833e-30	134.0	COG5279@1|root,COG5279@2|Bacteria,1V8TE@1239|Firmicutes,24CI3@186801|Clostridia,36GZB@31979|Clostridiaceae	186801|Clostridia	D	transglutaminase	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Cu_amine_oxidN1,Transglut_core
DEZH2_k127_6669762_2	1410638.JHXJ01000010_gene161	1.525e-50	184.0	COG3428@1|root,COG3428@2|Bacteria,1V9YB@1239|Firmicutes,24MQT@186801|Clostridia,3WJDY@541000|Ruminococcaceae	186801|Clostridia	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
DEZH2_k127_6669762_1	1392491.JIAE01000001_gene1176	2.588e-55	195.0	COG0846@1|root,COG0846@2|Bacteria,1TQKD@1239|Firmicutes,2491J@186801|Clostridia,3WGSY@541000|Ruminococcaceae	186801|Clostridia	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
DEZH2_k127_6721170_0	469596.HMPREF9488_01296	2.39e-60	215.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,3VPEW@526524|Erysipelotrichia	526524|Erysipelotrichia	E	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
DEZH2_k127_6721170_2	411490.ANACAC_01990	1.7e-45	172.0	COG1410@1|root,COG1410@2|Bacteria,1V7JJ@1239|Firmicutes,24AE1@186801|Clostridia	186801|Clostridia	E	vitamin B12 dependent methionine synthase, activation	metH2	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_synt_B12
DEZH2_k127_6721170_1	1117379.BABA_03204	2.076e-59	228.0	COG1835@1|root,COG1835@2|Bacteria,1V0J2@1239|Firmicutes,4HC92@91061|Bacilli,1ZEJF@1386|Bacillus	91061|Bacilli	I	Domain of unknown function (DUF4153)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4153
DEZH2_k127_6732102_0	1392491.JIAE01000001_gene1565	9.465e-126	410.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,3WHD2@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
DEZH2_k127_6732102_1	1392491.JIAE01000001_gene1564	4.841e-36	140.0	COG1939@1|root,COG1939@2|Bacteria,1VA5V@1239|Firmicutes,24MR1@186801|Clostridia,3WJN8@541000|Ruminococcaceae	186801|Clostridia	J	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)	mrnC	-	-	ko:K11145	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Ribonuclease_3
DEZH2_k127_6732102_2	1392491.JIAE01000001_gene1563	2.075e-22	102.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia,3WGPU@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
DEZH2_k127_674032_4	635013.TherJR_2632	2.252e-25	107.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,260DV@186807|Peptococcaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DEZH2_k127_674032_2	1295642.H839_10068	8.564e-66	231.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,4HA7D@91061|Bacilli,1WEED@129337|Geobacillus	91061|Bacilli	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_674032_1	1196322.A370_00111	2.515e-71	261.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36DKF@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
DEZH2_k127_674032_5	6087.XP_004206956.1	5.944e-15	85.0	2CXTH@1|root,2RZKM@2759|Eukaryota,3A38H@33154|Opisthokonta,3BQSZ@33208|Metazoa	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	YqaJ
DEZH2_k127_674032_3	1410653.JHVC01000015_gene734	2.154e-64	224.0	COG0645@1|root,COG0645@2|Bacteria,1V6NR@1239|Firmicutes,24E1G@186801|Clostridia,36PJR@31979|Clostridiaceae	186801|Clostridia	S	Zeta toxin	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
DEZH2_k127_674032_0	1499683.CCFF01000017_gene2539	7.491e-238	755.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,36EVW@31979|Clostridiaceae	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
DEZH2_k127_6806309_4	411474.COPEUT_02856	8.715e-14	76.0	COG2819@1|root,COG2819@2|Bacteria,1VCPU@1239|Firmicutes,24PM8@186801|Clostridia	186801|Clostridia	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
DEZH2_k127_6806309_3	357809.Cphy_1068	5.047e-39	159.0	COG0226@1|root,COG0226@2|Bacteria,1VT8I@1239|Firmicutes,24IAW@186801|Clostridia	186801|Clostridia	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
DEZH2_k127_6806309_2	411489.CLOL250_00994	1.456e-93	313.0	COG2207@1|root,COG2207@2|Bacteria,1UZ5U@1239|Firmicutes,24DJM@186801|Clostridia,36JY8@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC
DEZH2_k127_6806309_1	877424.ATWC01000015_gene650	1.647e-120	396.0	COG2730@1|root,COG2730@2|Bacteria,1TQUA@1239|Firmicutes,248Y8@186801|Clostridia,27J4Q@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Cellulase (glycosyl hydrolase family 5)	celC	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase
DEZH2_k127_6806309_0	641112.ACOK01000067_gene74	9.89e-226	708.0	COG2273@1|root,COG2273@2|Bacteria,1TR5U@1239|Firmicutes,248GW@186801|Clostridia,3WHFJ@541000|Ruminococcaceae	186801|Clostridia	G	Glycosyl hydrolases family 16	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,CW_binding_1,Glyco_hydro_16,SLH
DEZH2_k127_6813723_1	398512.JQKC01000001_gene2190	8.517e-43	166.0	COG2199@1|root,COG2199@2|Bacteria,1VAHW@1239|Firmicutes,24MYS@186801|Clostridia,3WQ6U@541000|Ruminococcaceae	186801|Clostridia	T	Diguanylate cyclase, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,PAS_9,Peripla_BP_3,dCache_1
DEZH2_k127_6813723_2	1280680.AUJU01000050_gene3809	4.361e-23	104.0	COG1426@1|root,COG1426@2|Bacteria,1TV6K@1239|Firmicutes,253IG@186801|Clostridia,4C1KR@830|Butyrivibrio	186801|Clostridia	S	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
DEZH2_k127_6813723_0	877420.ATVW01000064_gene836	1.184e-63	223.0	COG3550@1|root,COG3550@2|Bacteria,1TR9A@1239|Firmicutes,24C9K@186801|Clostridia,27KH4@186928|unclassified Lachnospiraceae	186801|Clostridia	S	HipA-like C-terminal domain	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	Couple_hipA,HipA_C
DEZH2_k127_6835871_0	5722.XP_001313891.1	2.857e-92	323.0	COG4886@1|root,KOG0619@2759|Eukaryota	2759|Eukaryota	U	regulation of response to stimulus	-	-	-	-	-	-	-	-	-	-	-	-	LRR_5
DEZH2_k127_6835871_1	756499.Desde_1822	3.292e-43	163.0	COG0494@1|root,COG0494@2|Bacteria,1V6ET@1239|Firmicutes,25EBI@186801|Clostridia,267A9@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
DEZH2_k127_6873659_1	1392493.JIAB01000001_gene628	9.397e-41	165.0	COG1653@1|root,COG1653@2|Bacteria,1V4Z6@1239|Firmicutes,24YP6@186801|Clostridia,27MJJ@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
DEZH2_k127_6873659_0	1410638.JHXJ01000008_gene326	4.284e-62	219.0	COG1175@1|root,COG1175@2|Bacteria,1TQTC@1239|Firmicutes,24AQX@186801|Clostridia,3WI3S@541000|Ruminococcaceae	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
DEZH2_k127_6874467_0	1392491.JIAE01000001_gene2561	2.777e-296	925.0	COG3459@1|root,COG3459@2|Bacteria,1V191@1239|Firmicutes,24BR6@186801|Clostridia,3WHKW@541000|Ruminococcaceae	186801|Clostridia	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36
DEZH2_k127_6874467_1	313589.JNB_12488	2.53e-62	227.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria,4FF8K@85021|Intrasporangiaceae	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
DEZH2_k127_6874467_2	1291050.JAGE01000001_gene1884	1.403e-50	190.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18
DEZH2_k127_6885130_8	748727.CLJU_c14300	1.039e-09	59.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,36EK4@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_6885130_3	86416.Clopa_4686	6.403e-114	394.0	COG0577@1|root,COG0577@2|Bacteria,1TPHU@1239|Firmicutes,247QW@186801|Clostridia,36VPE@31979|Clostridiaceae	186801|Clostridia	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
DEZH2_k127_6885130_1	158190.SpiGrapes_1961	1.969e-117	386.0	28PJ3@1|root,2ZC8W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6885130_5	1120746.CCNL01000010_gene1241	2.44e-79	268.0	28NIH@1|root,2ZBJX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6885130_7	1163671.JAGI01000003_gene767	3.83e-17	85.0	2DN8N@1|root,32W43@2|Bacteria,1UIJQ@1239|Firmicutes,25G3B@186801|Clostridia,36V8X@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_6885130_4	1232443.BAIA02000075_gene462	1.624e-81	283.0	COG1879@1|root,COG1879@2|Bacteria,1VTWD@1239|Firmicutes,24YC2@186801|Clostridia,26A85@186813|unclassified Clostridiales	186801|Clostridia	G	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_4
DEZH2_k127_6885130_2	1304880.JAGB01000002_gene1719	1.764e-116	388.0	COG4214@1|root,COG4214@2|Bacteria,1VU1F@1239|Firmicutes,24XS9@186801|Clostridia	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
DEZH2_k127_6885130_0	1235835.C814_02788	1.471e-229	722.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,3WH2F@541000|Ruminococcaceae	186801|Clostridia	G	ABC-type sugar transport system, ATPase component	-	-	3.6.3.17	ko:K10548	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.5	-	-	ABC_tran
DEZH2_k127_6885130_6	1280671.AUJH01000008_gene255	4.053e-32	128.0	COG4213@1|root,COG4213@2|Bacteria,1TR3Q@1239|Firmicutes,2482X@186801|Clostridia,4BWQX@830|Butyrivibrio	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
DEZH2_k127_696000_1	273068.TTE2411	4.582e-41	162.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_C,Big_4,SLH,Trehalase
DEZH2_k127_696000_3	398512.JQKC01000002_gene1783	4.397e-18	86.0	2E5UQ@1|root,330IY@2|Bacteria,1VI50@1239|Firmicutes,24QVH@186801|Clostridia,3WM0Y@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_696000_0	742741.HMPREF9475_00466	1.329e-54	197.0	COG2206@1|root,COG2206@2|Bacteria,1UI74@1239|Firmicutes,25EC7@186801|Clostridia,220FC@1506553|Lachnoclostridium	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
DEZH2_k127_696000_2	573061.Clocel_2408	8.088e-35	138.0	COG0454@1|root,COG0456@2|Bacteria,1VCDS@1239|Firmicutes,25CUV@186801|Clostridia,36X11@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DEZH2_k127_696000_4	66692.ABC0679	1.364e-12	78.0	COG0457@1|root,COG2214@1|root,COG0457@2|Bacteria,COG2214@2|Bacteria,1UI6A@1239|Firmicutes,4ISFC@91061|Bacilli,1ZFEW@1386|Bacillus	91061|Bacilli	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1266
DEZH2_k127_6974524_2	1347392.CCEZ01000022_gene832	1.306e-75	264.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,36DU5@31979|Clostridiaceae	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
DEZH2_k127_6974524_0	1392491.JIAE01000001_gene958	6.191e-139	449.0	COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,3WI1X@541000|Ruminococcaceae	186801|Clostridia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
DEZH2_k127_6974524_3	1410638.JHXJ01000006_gene2526	3.671e-43	165.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,3WJK5@541000|Ruminococcaceae	186801|Clostridia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
DEZH2_k127_6974524_1	1410638.JHXJ01000006_gene2527	1.089e-87	293.0	COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,247QY@186801|Clostridia,3WGQP@541000|Ruminococcaceae	186801|Clostridia	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
DEZH2_k127_7033361_1	689781.AUJX01000008_gene617	1.447e-136	442.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,2PRB6@265975|Oribacterium	186801|Clostridia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
DEZH2_k127_7033361_2	1410638.JHXJ01000013_gene2304	2.321e-86	299.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,248RH@186801|Clostridia,3WGW9@541000|Ruminococcaceae	186801|Clostridia	K	Cell envelope-like function transcriptional attenuator common domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
DEZH2_k127_7033361_3	1291050.JAGE01000001_gene2075	2.291e-41	154.0	COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,24MMM@186801|Clostridia,3WJT1@541000|Ruminococcaceae	186801|Clostridia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
DEZH2_k127_7033361_0	398512.JQKC01000002_gene1761	1.35e-261	814.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,3WGUG@541000|Ruminococcaceae	186801|Clostridia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
DEZH2_k127_7052301_0	1392491.JIAE01000001_gene327	4.909e-255	790.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,3WGEG@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DEZH2_k127_7052301_1	1392491.JIAE01000001_gene328	2.899e-190	597.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,3WGI1@541000|Ruminococcaceae	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
DEZH2_k127_7059409_2	1121105.ATXL01000010_gene914	4.375e-63	218.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,4H9SP@91061|Bacilli,4B0D4@81852|Enterococcaceae	91061|Bacilli	P	E1-E2 ATPase	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
DEZH2_k127_7059409_3	994573.T472_0216640	1.096e-27	113.0	COG2608@1|root,COG2608@2|Bacteria,1VG8U@1239|Firmicutes,24TEQ@186801|Clostridia,36NJ2@31979|Clostridiaceae	186801|Clostridia	P	Heavy-metal-associated domain	-	-	-	-	-	-	-	-	-	-	-	-	HMA
DEZH2_k127_7059409_4	1297617.JPJD01000027_gene1291	5.245e-24	109.0	2CAZS@1|root,2ZQC5@2|Bacteria,1W1PV@1239|Firmicutes,254R0@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7059409_1	871963.Desdi_0215	7.363e-93	325.0	COG2197@1|root,COG2197@2|Bacteria,1UYM1@1239|Firmicutes,2497D@186801|Clostridia,263K8@186807|Peptococcaceae	186801|Clostridia	KT	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE
DEZH2_k127_7059409_0	871963.Desdi_0214	3.349e-137	451.0	COG1653@1|root,COG1653@2|Bacteria,1TRST@1239|Firmicutes,24APZ@186801|Clostridia,263M4@186807|Peptococcaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
DEZH2_k127_7059409_5	33035.JPJF01000074_gene5042	2.609e-09	59.0	COG0671@1|root,COG0671@2|Bacteria,1VB7J@1239|Firmicutes,24JDD@186801|Clostridia,3Y0A5@572511|Blautia	186801|Clostridia	I	COG COG0671 Membrane-associated phospholipid phosphatase	bcrC	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
DEZH2_k127_7080995_1	755731.Clo1100_3380	2.571e-12	70.0	COG3209@1|root,COG4733@1|root,COG3209@2|Bacteria,COG4733@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia,36F1J@31979|Clostridiaceae	186801|Clostridia	M	YD repeat (two copies)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,RHS_repeat
DEZH2_k127_7080995_2	469604.HMPREF0946_00578	0.0005067	45.0	COG2865@1|root,COG2865@2|Bacteria	2|Bacteria	-	-	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_11,HTH_24
DEZH2_k127_7080995_0	994573.T472_0216005	6.461e-129	421.0	COG2865@1|root,COG2865@2|Bacteria,1UZ2S@1239|Firmicutes,24B3T@186801|Clostridia,36NRU@31979|Clostridiaceae	186801|Clostridia	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2,HATPase_c_4,HTH_11,HTH_24
DEZH2_k127_7092680_1	1392491.JIAE01000001_gene1367	9.445e-51	184.0	COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,3WH1B@541000|Ruminococcaceae	186801|Clostridia	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
DEZH2_k127_7092680_0	1392491.JIAE01000001_gene1366	4.204e-161	519.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,3WGVK@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the ribose-phosphate pyrophosphokinase family	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran,Pribosyltran_N
DEZH2_k127_7092680_2	1392491.JIAE01000001_gene1365	1.367e-49	178.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,3WGVK@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the ribose-phosphate pyrophosphokinase family	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
DEZH2_k127_7102567_4	273068.TTE2411	1.253e-09	65.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_C,Big_4,SLH,Trehalase
DEZH2_k127_7102567_1	903814.ELI_2349	4.109e-69	245.0	COG0642@1|root,COG2205@2|Bacteria,1UZKD@1239|Firmicutes,249N3@186801|Clostridia,25WS0@186806|Eubacteriaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
DEZH2_k127_7102567_3	428125.CLOLEP_02855	2.916e-25	115.0	COG1277@1|root,COG1277@2|Bacteria,1VIB7@1239|Firmicutes,24QIN@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
DEZH2_k127_7102567_0	428125.CLOLEP_02856	1.183e-101	339.0	COG1131@1|root,COG1131@2|Bacteria,1TPBQ@1239|Firmicutes,247M8@186801|Clostridia,3WHBQ@541000|Ruminococcaceae	186801|Clostridia	V	ABC transporter	bcrA2	-	-	ko:K01990,ko:K19309	ko02010,map02010	M00254,M00747	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.131.1	-	-	ABC_tran
DEZH2_k127_7102567_2	1235798.C817_04218	5.733e-36	138.0	COG0745@1|root,COG0745@2|Bacteria,1TT2Z@1239|Firmicutes,248PN@186801|Clostridia,27VYI@189330|Dorea	186801|Clostridia	KT	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_7144011_3	1392491.JIAE01000001_gene933	5.135e-43	161.0	COG2001@1|root,COG2001@2|Bacteria	2|Bacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
DEZH2_k127_7144011_2	1392491.JIAE01000001_gene934	3.851e-116	382.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,3WH07@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
DEZH2_k127_7144011_5	588581.Cpap_1072	1.973e-05	54.0	COG2919@1|root,COG2919@2|Bacteria,1VK5R@1239|Firmicutes,24GRJ@186801|Clostridia	186801|Clostridia	D	cell division protein FtsL	-	-	-	-	-	-	-	-	-	-	-	-	DivIC,FtsL
DEZH2_k127_7144011_0	1392491.JIAE01000001_gene936	1.184e-207	672.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,3WGI4@541000|Ruminococcaceae	186801|Clostridia	M	Penicillin-binding Protein	ftsI	-	-	ko:K08384	ko00550,map00550	-	-	-	ko00000,ko00001,ko01011	-	-	-	PASTA,PBP_dimer,Transpeptidase
DEZH2_k127_7144011_1	1392491.JIAE01000001_gene937	2.237e-172	554.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,3WHE3@541000|Ruminococcaceae	186801|Clostridia	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
DEZH2_k127_7144011_4	1392491.JIAE01000001_gene938	3.242e-34	136.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,3WN55@541000|Ruminococcaceae	186801|Clostridia	M	Mur ligase middle domain	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
DEZH2_k127_7156597_3	1121335.Clst_0561	9.587e-20	101.0	COG0577@1|root,COG0577@2|Bacteria,1VEXI@1239|Firmicutes,24SD7@186801|Clostridia,3WQSH@541000|Ruminococcaceae	186801|Clostridia	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7156597_5	1121335.Clst_0562	5.204e-12	77.0	2EPHD@1|root,33H40@2|Bacteria,1VNCY@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MacB_PCD
DEZH2_k127_7156597_1	573061.Clocel_0157	5.632e-61	213.0	COG5646@1|root,COG5646@2|Bacteria,1V6QB@1239|Firmicutes,24K4J@186801|Clostridia,36JND@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
DEZH2_k127_7156597_2	1223410.KN050846_gene2704	4.394e-54	194.0	COG5646@1|root,COG5646@2|Bacteria,4NNPA@976|Bacteroidetes,1I1Y8@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
DEZH2_k127_7156597_0	1354300.AUQY01000002_gene1303	3.325e-71	245.0	COG0693@1|root,COG0693@2|Bacteria,1V8MR@1239|Firmicutes,24MDD@186801|Clostridia,22IYE@1570339|Peptoniphilaceae	186801|Clostridia	S	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
DEZH2_k127_7156597_4	1266845.Q783_08795	3.432e-19	89.0	2E9V0@1|root,3340V@2|Bacteria,1V6HR@1239|Firmicutes,4HIXZ@91061|Bacilli,27GRI@186828|Carnobacteriaceae	91061|Bacilli	M	carotenoid biosynthetic process	-	-	-	ko:K10212	ko00906,map00906	-	R07656	RC00041	ko00000,ko00001,ko01000	-	-	-	-
DEZH2_k127_7221133_0	1034345.CAEM01000012_gene719	2.063e-269	842.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2GN09@201174|Actinobacteria,4CUX8@84998|Coriobacteriia	84998|Coriobacteriia	E	Conserved region in glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
DEZH2_k127_7221133_1	1196322.A370_05037	2.104e-53	193.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,2490X@186801|Clostridia,36EKI@31979|Clostridiaceae	186801|Clostridia	C	Glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
DEZH2_k127_7221558_0	632245.CLP_0141	6.316e-132	429.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,36FA1@31979|Clostridiaceae	186801|Clostridia	E	phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS14395	DAHP_synth_1
DEZH2_k127_7221558_2	1203606.HMPREF1526_00134	4.797e-64	237.0	COG0169@1|root,COG0703@1|root,COG0169@2|Bacteria,COG0703@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,36E3G@31979|Clostridiaceae	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI,Shikimate_DH,Shikimate_dh_N
DEZH2_k127_7221558_1	1121335.Clst_2222	3.704e-71	254.0	COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia,3WI06@541000|Ruminococcaceae	186801|Clostridia	E	prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDH
DEZH2_k127_7221558_3	1392491.JIAE01000001_gene388	1.732e-60	211.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,3WHHZ@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2,LuxC
DEZH2_k127_7235387_0	1392491.JIAE01000001_gene319	6.409e-64	228.0	COG1272@1|root,COG1272@2|Bacteria,1TSFK@1239|Firmicutes,24CPT@186801|Clostridia,3WIQK@541000|Ruminococcaceae	186801|Clostridia	S	Haemolysin-III related	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
DEZH2_k127_7235387_1	626939.HMPREF9443_00750	6.623e-25	106.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,4H597@909932|Negativicutes	909932|Negativicutes	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
DEZH2_k127_7239212_3	1174504.AJTN02000227_gene4795	2.55e-19	90.0	COG0738@1|root,COG0738@2|Bacteria,1TPB5@1239|Firmicutes,4HAUM@91061|Bacilli,1ZDHE@1386|Bacillus	91061|Bacilli	G	Major Facilitator Superfamily	-	-	-	ko:K08174	-	-	-	-	ko00000,ko02000	2.A.1.7	-	-	MFS_1
DEZH2_k127_7239212_0	1392491.JIAE01000001_gene627	4.89e-140	458.0	COG4198@1|root,COG4198@2|Bacteria,1TQ52@1239|Firmicutes,24985@186801|Clostridia,3WGM6@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
DEZH2_k127_7239212_1	1410638.JHXJ01000027_gene1190	1.694e-88	307.0	COG1232@1|root,COG1232@2|Bacteria,1UQZD@1239|Firmicutes,24VCQ@186801|Clostridia,3WMB9@541000|Ruminococcaceae	186801|Clostridia	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
DEZH2_k127_7239212_2	1392491.JIAE01000001_gene625	3.927e-60	218.0	COG5427@1|root,COG5427@2|Bacteria,1UY7V@1239|Firmicutes,24BA0@186801|Clostridia,3WHM2@541000|Ruminococcaceae	186801|Clostridia	S	Uncharacterized membrane protein (DUF2298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298
DEZH2_k127_7266038_0	1195236.CTER_1794	7.858e-106	364.0	COG2972@1|root,COG2972@2|Bacteria,1UXY6@1239|Firmicutes,24CN6@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,His_kinase
DEZH2_k127_7266038_1	1121335.Clst_0471	2.367e-36	143.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UYH7@1239|Firmicutes,249E3@186801|Clostridia	186801|Clostridia	T	response regulator	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
DEZH2_k127_7270144_3	1504823.CCMM01000011_gene1524	2.909e-06	51.0	COG0697@1|root,COG0697@2|Bacteria,2NPMX@2323|unclassified Bacteria	2|Bacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DEZH2_k127_7270144_0	641107.CDLVIII_4018	6.212e-62	219.0	COG2220@1|root,COG2220@2|Bacteria,1UJWI@1239|Firmicutes,24G6N@186801|Clostridia	186801|Clostridia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
DEZH2_k127_7270144_1	270374.MELB17_04972	3.7e-36	139.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,1SCYV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	TIGRFAM Addiction module antidote protein, HigA	higA	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
DEZH2_k127_7270144_2	32057.KB217478_gene1538	1.644e-08	55.0	COG3549@1|root,COG3549@2|Bacteria,1GPIJ@1117|Cyanobacteria,1HPXK@1161|Nostocales	1117|Cyanobacteria	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
DEZH2_k127_7272310_0	1121289.JHVL01000042_gene3092	7.616e-18	98.0	COG1653@1|root,COG1653@2|Bacteria,1V4Z6@1239|Firmicutes,25BYR@186801|Clostridia,36W5C@31979|Clostridiaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7272310_1	1392491.JIAE01000001_gene2569	1.979e-06	49.0	COG1653@1|root,COG1653@2|Bacteria,1V4Z6@1239|Firmicutes,24FVZ@186801|Clostridia,3WMJD@541000|Ruminococcaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
DEZH2_k127_7272838_9	1392491.JIAE01000001_gene1308	1e-70	245.0	COG0345@1|root,COG0345@2|Bacteria,1TP1E@1239|Firmicutes,247SR@186801|Clostridia,3WGT7@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
DEZH2_k127_7272838_11	720554.Clocl_1464	3.029e-60	211.0	COG0328@1|root,COG0328@2|Bacteria,1V4A0@1239|Firmicutes,24FSS@186801|Clostridia,3WISH@541000|Ruminococcaceae	186801|Clostridia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
DEZH2_k127_7272838_13	1392491.JIAE01000001_gene1310	3.283e-55	199.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,3WJNN@541000|Ruminococcaceae	186801|Clostridia	L	Psort location Cytoplasmic, score	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
DEZH2_k127_7272838_1	699246.HMPREF0868_0628	2.704e-182	602.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia,267KR@186813|unclassified Clostridiales	186801|Clostridia	D	Ftsk_gamma	spoIIIE	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
DEZH2_k127_7272838_7	796606.BMMGA3_11410	2.397e-101	338.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,4H9Q6@91061|Bacilli,1ZC9G@1386|Bacillus	91061|Bacilli	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
DEZH2_k127_7272838_4	1195236.CTER_2209	4.4e-115	384.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,3WGRD@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
DEZH2_k127_7272838_6	1392491.JIAE01000001_gene1313	1.935e-106	360.0	COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,3WHRU@541000|Ruminococcaceae	186801|Clostridia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
DEZH2_k127_7272838_17	1410638.JHXJ01000023_gene832	4.552e-06	54.0	COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,3WHRU@541000|Ruminococcaceae	186801|Clostridia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
DEZH2_k127_7272838_2	1410638.JHXJ01000023_gene828	3.594e-167	532.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,3WGST@541000|Ruminococcaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
DEZH2_k127_7272838_16	699246.HMPREF0868_0633	3.496e-13	76.0	COG2137@1|root,COG2137@2|Bacteria,1UTZK@1239|Firmicutes,254ZQ@186801|Clostridia	186801|Clostridia	S	RecX family	-	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
DEZH2_k127_7272838_3	1392491.JIAE01000001_gene1316	6.134e-159	513.0	COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,3WH46@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
DEZH2_k127_7272838_10	1392491.JIAE01000001_gene1317	3.048e-61	217.0	COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,24J7Y@186801|Clostridia,3WK01@541000|Ruminococcaceae	186801|Clostridia	I	CDP-alcohol phosphatidyltransferase	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
DEZH2_k127_7272838_14	699246.HMPREF0868_0637	1.626e-26	110.0	COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,24QME@186801|Clostridia	186801|Clostridia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
DEZH2_k127_7272838_12	1304284.L21TH_0694	2.716e-55	201.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,36FEP@31979|Clostridiaceae	186801|Clostridia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
DEZH2_k127_7272838_0	1392491.JIAE01000001_gene1320	1.082e-320	1019.0	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia,3WH4V@541000|Ruminococcaceae	186801|Clostridia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
DEZH2_k127_7272838_5	1392491.JIAE01000001_gene1321	1.574e-109	362.0	COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia,3WGFT@541000|Ruminococcaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
DEZH2_k127_7272838_15	1392491.JIAE01000001_gene1437	2.158e-22	100.0	COG2739@1|root,COG2739@2|Bacteria,1VEGP@1239|Firmicutes,24QNM@186801|Clostridia,3WK5U@541000|Ruminococcaceae	186801|Clostridia	S	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein	-	-	-	ko:K09787	-	-	-	-	ko00000	-	-	-	UPF0122
DEZH2_k127_7272838_8	1392491.JIAE01000001_gene1436	4.191e-79	268.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,3WH5J@541000|Ruminococcaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
DEZH2_k127_7273237_0	1410609.JHVB01000011_gene1599	1.162e-171	548.0	COG1979@1|root,COG1979@2|Bacteria,2J57G@203691|Spirochaetes	203691|Spirochaetes	C	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
DEZH2_k127_7273237_1	1410638.JHXJ01000001_gene1907	4.519e-111	364.0	COG0708@1|root,COG0708@2|Bacteria,1TPFB@1239|Firmicutes,24849@186801|Clostridia,3WGQM@541000|Ruminococcaceae	186801|Clostridia	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
DEZH2_k127_7273237_2	552398.HMPREF0866_01890	8.69e-70	249.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,3WJE5@541000|Ruminococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
DEZH2_k127_7273237_4	1392491.JIAE01000001_gene343	2.06e-28	127.0	COG0252@1|root,COG0252@2|Bacteria	2|Bacteria	EJ	asparaginase activity	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
DEZH2_k127_7273237_5	1280671.AUJH01000012_gene3200	0.0009522	42.0	COG0507@1|root,COG0507@2|Bacteria,1VQVT@1239|Firmicutes,24YPM@186801|Clostridia,4BXJU@830|Butyrivibrio	186801|Clostridia	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7295784_0	1392491.JIAE01000001_gene1329	2.531e-179	569.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,3WGQZ@541000|Ruminococcaceae	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
DEZH2_k127_7305315_1	1035196.HMPREF9998_01841	7.039e-131	429.0	COG1373@1|root,COG1373@2|Bacteria,1TP7X@1239|Firmicutes,247ZX@186801|Clostridia,25S3U@186804|Peptostreptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
DEZH2_k127_7305315_2	941824.TCEL_02213	3.347e-23	105.0	2AP0P@1|root,31E1T@2|Bacteria,1UTP9@1239|Firmicutes,253SU@186801|Clostridia,36SHW@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7305315_0	626939.HMPREF9443_01810	5.119e-132	435.0	COG2865@1|root,COG2865@2|Bacteria,1TSPK@1239|Firmicutes,4H3M4@909932|Negativicutes	909932|Negativicutes	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_24
DEZH2_k127_7307551_1	1392491.JIAE01000001_gene499	1.239e-100	333.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,3WHBU@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
DEZH2_k127_7307551_2	398512.JQKC01000007_gene1182	3.579e-21	107.0	COG2367@1|root,COG2367@2|Bacteria,1UYZ3@1239|Firmicutes,24B7W@186801|Clostridia,3WINT@541000|Ruminococcaceae	186801|Clostridia	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2,DUF4214
DEZH2_k127_7307551_3	1174504.AJTN02000162_gene1595	6.785e-05	48.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,4HAUE@91061|Bacilli,1ZB2M@1386|Bacillus	91061|Bacilli	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
DEZH2_k127_7307551_0	1392491.JIAE01000001_gene497	2.907e-129	427.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,3WGA1@541000|Ruminococcaceae	186801|Clostridia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
DEZH2_k127_7308185_0	1123075.AUDP01000014_gene3011	1.404e-73	254.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,3WH2R@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
DEZH2_k127_7308185_2	906968.Trebr_0850	2.66e-15	79.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2J65C@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
DEZH2_k127_7308185_1	1392491.JIAE01000001_gene1169	2.055e-49	184.0	COG1670@1|root,COG1670@2|Bacteria,1V1ZC@1239|Firmicutes,249K2@186801|Clostridia,3WQ7J@541000|Ruminococcaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	yjcK	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3,Acetyltransf_4
DEZH2_k127_7311553_0	645991.Sgly_2654	6.301e-126	406.0	COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,247KC@186801|Clostridia,260EJ@186807|Peptococcaceae	186801|Clostridia	S	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_7311553_1	37659.JNLN01000001_gene2811	2.986e-17	85.0	COG5658@1|root,COG5658@2|Bacteria,1VB6E@1239|Firmicutes,24MSY@186801|Clostridia,36N1V@31979|Clostridiaceae	186801|Clostridia	S	SdpI/YhfL protein family	-	-	-	-	-	-	-	-	-	-	-	-	SdpI
DEZH2_k127_7315886_0	1410638.JHXJ01000011_gene681	2.591e-97	332.0	COG0204@1|root,COG0204@2|Bacteria,1V11X@1239|Firmicutes,24AAK@186801|Clostridia,3WI41@541000|Ruminococcaceae	186801|Clostridia	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
DEZH2_k127_7337888_2	398512.JQKC01000023_gene3281	1.737e-08	55.0	2DPV4@1|root,333HA@2|Bacteria,1VH7Z@1239|Firmicutes,24SC2@186801|Clostridia,3WQ8C@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7337888_0	1392491.JIAE01000001_gene1998	8.678e-315	984.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,3WGBM@541000|Ruminococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
DEZH2_k127_7345887_2	1121333.JMLH01000061_gene1415	6.902e-87	291.0	COG1876@1|root,COG1876@2|Bacteria,1TQQ3@1239|Firmicutes	1239|Firmicutes	M	Clostridial hydrophobic, with a conserved W residue, domain.	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,ChW,Esterase,Glucosaminidase,Glyco_hydro_25,Peptidase_C39_2
DEZH2_k127_7345887_1	33035.JPJF01000046_gene1004	9.358e-98	343.0	COG1680@1|root,COG1680@2|Bacteria,1TRQD@1239|Firmicutes,25B1Y@186801|Clostridia	186801|Clostridia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
DEZH2_k127_7345887_0	931626.Awo_c04180	4.542e-133	443.0	COG1876@1|root,COG1876@2|Bacteria,1V1F7@1239|Firmicutes,24E6R@186801|Clostridia,25WI1@186806|Eubacteriaceae	186801|Clostridia	M	D-alanyl-D-alanine carboxypeptidase	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	DUF348,G5,VanY
DEZH2_k127_7372910_8	1410638.JHXJ01000002_gene1414	3.435e-29	117.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,3WG9F@541000|Ruminococcaceae	186801|Clostridia	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
DEZH2_k127_7372910_6	208596.CAR_c04960	2.555e-46	179.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,4HB6B@91061|Bacilli	91061|Bacilli	J	metal-dependent phosphoesterases (PHP family)	-	-	3.1.4.57	ko:K20859	ko00440,map00440	-	R10972,R10973	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	PHP
DEZH2_k127_7372910_5	1487921.DP68_00975	4.053e-55	197.0	COG1522@1|root,COG1522@2|Bacteria,1V3PB@1239|Firmicutes,24I3N@186801|Clostridia,36DXZ@31979|Clostridiaceae	186801|Clostridia	K	AsnC family	Lrp	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
DEZH2_k127_7372910_2	1410638.JHXJ01000002_gene1416	4.824e-171	544.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,3WGAJ@541000|Ruminococcaceae	186801|Clostridia	E	Aminotransferase	aspC	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
DEZH2_k127_7372910_1	1392491.JIAE01000001_gene1495	2.972e-180	569.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,3WG91@541000|Ruminococcaceae	186801|Clostridia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
DEZH2_k127_7372910_4	545697.HMPREF0216_00438	2.644e-78	276.0	COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia,36ECU@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	czcD	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
DEZH2_k127_7372910_0	1392491.JIAE01000001_gene1468	1.179e-204	665.0	COG1368@1|root,COG1368@2|Bacteria,1TRMA@1239|Firmicutes,2480C@186801|Clostridia,3WGEK@541000|Ruminococcaceae	186801|Clostridia	M	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
DEZH2_k127_7383032_0	1410638.JHXJ01000010_gene146	1.001e-161	512.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,3WGVK@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the ribose-phosphate pyrophosphokinase family	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
DEZH2_k127_7383032_1	1304880.JAGB01000002_gene1871	7.69e-153	493.0	COG1883@1|root,COG1883@2|Bacteria,1TPEP@1239|Firmicutes,248ET@186801|Clostridia	186801|Clostridia	C	decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
DEZH2_k127_7383032_2	1392491.JIAE01000001_gene1362	3.419e-142	473.0	COG1293@1|root,COG1293@2|Bacteria,1TQ8A@1239|Firmicutes,248RK@186801|Clostridia,3WG7T@541000|Ruminococcaceae	186801|Clostridia	K	Fibronectin-binding protein	FbpA	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
DEZH2_k127_7383032_3	1392491.JIAE01000001_gene1361	7.517e-38	146.0	COG1636@1|root,COG1636@2|Bacteria,1TT7H@1239|Firmicutes,248EA@186801|Clostridia,3WGWP@541000|Ruminococcaceae	186801|Clostridia	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
DEZH2_k127_7398510_2	479437.Elen_0388	1.423e-59	213.0	COG1335@1|root,COG1335@2|Bacteria,2IN6N@201174|Actinobacteria,4CVQU@84998|Coriobacteriia	84998|Coriobacteriia	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
DEZH2_k127_7398510_0	1125699.HMPREF9194_01847	1.895e-129	428.0	COG2723@1|root,COG2723@2|Bacteria,2J6C8@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
DEZH2_k127_7398510_3	1410638.JHXJ01000010_gene101	5.809e-58	210.0	COG2365@1|root,COG2365@2|Bacteria,1VA24@1239|Firmicutes,24J7G@186801|Clostridia,3WRQB@541000|Ruminococcaceae	186801|Clostridia	T	Tyrosine phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Y_phosphatase3
DEZH2_k127_7398510_4	1392491.JIAE01000001_gene1562	5.524e-25	119.0	2CK4V@1|root,2ZUQF@2|Bacteria,1W326@1239|Firmicutes,257AB@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7398510_1	1408254.T458_24995	7.679e-79	269.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,4HBBI@91061|Bacilli,26RQZ@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	trmH	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
DEZH2_k127_7412900_2	1280685.AUKC01000006_gene1817	1.409e-49	179.0	COG4099@1|root,COG4099@2|Bacteria,1TRER@1239|Firmicutes,2492V@186801|Clostridia,4BXE2@830|Butyrivibrio	186801|Clostridia	G	Phospholipase/Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,BAAT_C
DEZH2_k127_7412900_0	198094.BA_1282	2.673e-79	271.0	COG0500@1|root,COG0500@2|Bacteria,1UZQD@1239|Firmicutes,4IS7Z@91061|Bacilli,1ZCK3@1386|Bacillus	91061|Bacilli	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
DEZH2_k127_7412900_1	1195236.CTER_4856	1.74e-52	191.0	COG0563@1|root,COG0563@2|Bacteria,1UJD5@1239|Firmicutes,24BY9@186801|Clostridia	186801|Clostridia	F	adenylate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18
DEZH2_k127_7452569_4	1392491.JIAE01000001_gene938	2.687e-84	292.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,3WN55@541000|Ruminococcaceae	186801|Clostridia	M	Mur ligase middle domain	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
DEZH2_k127_7452569_5	699246.HMPREF0868_0340	8.467e-77	274.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,2682V@186813|unclassified Clostridiales	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
DEZH2_k127_7452569_3	429009.Adeg_1564	7.284e-89	305.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,42F8I@68295|Thermoanaerobacterales	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
DEZH2_k127_7452569_14	1321814.HMPREF9089_00604	1.442e-06	59.0	COG1589@1|root,COG1589@2|Bacteria,1VG7K@1239|Firmicutes,25MVP@186801|Clostridia,25XQE@186806|Eubacteriaceae	186801|Clostridia	D	Cell division protein FtsQ	-	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	POTRA_1
DEZH2_k127_7452569_11	857293.CAAU_1281	4.168e-29	120.0	COG3856@1|root,COG3856@2|Bacteria,1VA6N@1239|Firmicutes,24N58@186801|Clostridia,36JGG@31979|Clostridiaceae	186801|Clostridia	S	small basic protein	sbp	-	-	-	-	-	-	-	-	-	-	-	DUF1290
DEZH2_k127_7452569_0	1392491.JIAE01000001_gene942	1.514e-167	541.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,3WH3G@541000|Ruminococcaceae	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
DEZH2_k127_7452569_6	203119.Cthe_0450	3.02e-61	214.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,3WJ07@541000|Ruminococcaceae	186801|Clostridia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
DEZH2_k127_7452569_2	1410638.JHXJ01000028_gene1248	6.411e-109	357.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,3WGB8@541000|Ruminococcaceae	186801|Clostridia	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_7452569_12	699246.HMPREF0868_0347	7.951e-28	124.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,268NH@186813|unclassified Clostridiales	186801|Clostridia	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
DEZH2_k127_7452569_9	1392491.JIAE01000001_gene945	3.533e-49	181.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,3WSMC@541000|Ruminococcaceae	186801|Clostridia	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
DEZH2_k127_7452569_7	555079.Toce_1511	2.21e-59	212.0	COG0177@1|root,COG0177@2|Bacteria,1TRAK@1239|Firmicutes,24899@186801|Clostridia,42G26@68295|Thermoanaerobacterales	186801|Clostridia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
DEZH2_k127_7452569_1	742738.HMPREF9460_02550	1.344e-161	534.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,267P4@186813|unclassified Clostridiales	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
DEZH2_k127_7452569_8	1392491.JIAE01000001_gene948	2.285e-52	191.0	COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia,3WJC4@541000|Ruminococcaceae	186801|Clostridia	L	RNA methyltransferase, RsmD family	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
DEZH2_k127_7452569_10	1121296.JONJ01000002_gene1353	1.793e-40	155.0	COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia,21YQA@1506553|Lachnoclostridium	186801|Clostridia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
DEZH2_k127_7452569_13	1121335.Clst_0750	9.056e-23	104.0	COG0711@1|root,COG0711@2|Bacteria,1V97P@1239|Firmicutes,24JGQ@186801|Clostridia,3WK11@541000|Ruminococcaceae	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7457354_10	585501.HMPREF6123_0476	4.229e-07	57.0	COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia,2PQMQ@265975|Oribacterium	186801|Clostridia	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
DEZH2_k127_7457354_2	555079.Toce_1766	7.212e-184	586.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,42EU3@68295|Thermoanaerobacterales	186801|Clostridia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
DEZH2_k127_7457354_8	59374.Fisuc_2394	7.071e-18	87.0	2E5T4@1|root,330HF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7457354_3	1410638.JHXJ01000002_gene1369	4.852e-127	412.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,3WHXD@541000|Ruminococcaceae	186801|Clostridia	GK	ROK family	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10220	ROK
DEZH2_k127_7457354_7	404589.Anae109_0108	2.172e-20	94.0	COG4627@1|root,COG4627@2|Bacteria,1N8RI@1224|Proteobacteria,43BG0@68525|delta/epsilon subdivisions,2X6UB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Stress responsive alpha-beta barrel	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
DEZH2_k127_7457354_5	1392491.JIAE01000001_gene1618	7.673e-75	265.0	COG1721@1|root,COG1721@2|Bacteria,1TSYT@1239|Firmicutes,249GJ@186801|Clostridia,3WGMG@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
DEZH2_k127_7457354_4	1392491.JIAE01000001_gene1619	8.224e-118	387.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia,3WG8K@541000|Ruminococcaceae	186801|Clostridia	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
DEZH2_k127_7457354_6	1131462.DCF50_p977	3.148e-68	236.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1V26G@1239|Firmicutes,24HYB@186801|Clostridia,266SZ@186807|Peptococcaceae	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
DEZH2_k127_7457354_1	1121423.JONT01000018_gene134	1.452e-273	850.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,25AZ5@186801|Clostridia,263VJ@186807|Peptococcaceae	186801|Clostridia	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C,Cupin_2,HTH_3
DEZH2_k127_7457354_0	1392491.JIAE01000001_gene1555	0.0	1315.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,3WHFT@541000|Ruminococcaceae	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
DEZH2_k127_7462835_1	1392491.JIAE01000001_gene2218	7.015e-138	440.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,3WGWJ@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
DEZH2_k127_7462835_2	1392491.JIAE01000001_gene2217	1.756e-59	210.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia,3WIJW@541000|Ruminococcaceae	186801|Clostridia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
DEZH2_k127_7462835_0	720554.Clocl_3911	2.261e-209	662.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,3WH32@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
DEZH2_k127_7462835_3	903814.ELI_1622	1.64e-32	142.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,25VJW@186806|Eubacteriaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,FtsX
DEZH2_k127_7489026_1	2325.TKV_c01900	7.177e-43	167.0	COG0348@1|root,COG0348@2|Bacteria,1V8RW@1239|Firmicutes,24JXS@186801|Clostridia,42GUZ@68295|Thermoanaerobacterales	186801|Clostridia	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7489026_0	273068.TTE1096	1.825e-107	355.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,42FWZ@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	ko:K02574	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4,Fer4_5
DEZH2_k127_7494615_0	1392491.JIAE01000001_gene1255	6.971e-55	201.0	COG0641@1|root,COG0641@2|Bacteria,1V5ZZ@1239|Firmicutes,24IY0@186801|Clostridia,3WRPY@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM superfamily	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
DEZH2_k127_7494615_2	1211817.CCAT010000043_gene3598	1.105e-15	77.0	COG1670@1|root,COG1670@2|Bacteria,1V6E0@1239|Firmicutes,24G2M@186801|Clostridia	186801|Clostridia	J	acetyltransferase, GNAT family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
DEZH2_k127_7494615_1	1211817.CCAT010000043_gene3598	2.646e-52	187.0	COG1670@1|root,COG1670@2|Bacteria,1V6E0@1239|Firmicutes,24G2M@186801|Clostridia	186801|Clostridia	J	acetyltransferase, GNAT family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
DEZH2_k127_7521857_0	755731.Clo1100_1353	9.792e-208	663.0	COG2730@1|root,COG2730@2|Bacteria,1TSJQ@1239|Firmicutes,247IR@186801|Clostridia,36GWY@31979|Clostridiaceae	186801|Clostridia	G	hydrolase family 5	celA	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_17_28,CBM_2,Cellulase,SLH
DEZH2_k127_7521857_2	1121423.JONT01000031_gene863	2.283e-168	555.0	COG1401@1|root,COG2947@1|root,COG1401@2|Bacteria,COG2947@2|Bacteria,1TPIP@1239|Firmicutes,249RD@186801|Clostridia,265DG@186807|Peptococcaceae	186801|Clostridia	L	AAA domain (dynein-related subfamily)	mcrB	-	-	ko:K07452	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	AAA_5,EVE,Mrr_N
DEZH2_k127_7521857_1	293826.Amet_2952	3.351e-182	578.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,36EGF@31979|Clostridiaceae	186801|Clostridia	L	DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
DEZH2_k127_7521857_3	1410608.JNKX01000016_gene2494	2.042e-32	135.0	COG5263@1|root,COG5263@2|Bacteria,4NJ6B@976|Bacteroidetes,2FU00@200643|Bacteroidia,4AS6J@815|Bacteroidaceae	976|Bacteroidetes	S	WG containing repeat	-	-	-	-	-	-	-	-	-	-	-	-	WG_beta_rep
DEZH2_k127_7533386_3	699246.HMPREF0868_0866	1.501e-32	130.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,267WA@186813|unclassified Clostridiales	186801|Clostridia	C	4Fe-4S single cluster domain	scfB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
DEZH2_k127_7533386_1	203119.Cthe_0905	9.412e-77	263.0	COG3294@1|root,COG3294@2|Bacteria,1UXSS@1239|Firmicutes,24A8Y@186801|Clostridia,3WGCK@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
DEZH2_k127_7533386_0	1392491.JIAE01000001_gene1502	1.02e-143	477.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,3WGFW@541000|Ruminococcaceae	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
DEZH2_k127_7533386_4	1392491.JIAE01000001_gene1501	2.911e-32	134.0	COG2384@1|root,COG2384@2|Bacteria,1V3I4@1239|Firmicutes,24BJI@186801|Clostridia,3WKA4@541000|Ruminococcaceae	186801|Clostridia	S	SAM-dependent methyltransferase	trmK	-	2.1.1.217	ko:K06967	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_18,TrmK
DEZH2_k127_7533386_2	588581.Cpap_0418	2.586e-38	153.0	COG0327@1|root,COG0327@2|Bacteria,1TQ27@1239|Firmicutes,248Q2@186801|Clostridia,3WJ9H@541000|Ruminococcaceae	186801|Clostridia	S	dinuclear metal center protein, YbgI	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
DEZH2_k127_7535182_3	936596.HMPREF1495_1369	1.397e-48	189.0	COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,1TT2K@1239|Firmicutes,24965@186801|Clostridia,1HVB8@1164882|Lachnoanaerobaculum	186801|Clostridia	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	LysM,NLPC_P60,PG_binding_1
DEZH2_k127_7535182_2	411463.EUBVEN_02292	1.359e-51	186.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,25WZC@186806|Eubacteriaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
DEZH2_k127_7535182_0	349741.Amuc_2013	3.171e-222	696.0	COG2873@1|root,COG2873@2|Bacteria,46TEJ@74201|Verrucomicrobia,2ITJ5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
DEZH2_k127_7535182_1	1291050.JAGE01000001_gene1372	2.354e-148	473.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,3WG9Z@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DEZH2_k127_7559425_0	1392491.JIAE01000001_gene923	1.183e-256	799.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,3WHTD@541000|Ruminococcaceae	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
DEZH2_k127_7559425_5	1408422.JHYF01000001_gene3028	3.337e-28	117.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,36JIF@31979|Clostridiaceae	186801|Clostridia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
DEZH2_k127_7559425_3	1410638.JHXJ01000028_gene1232	1.431e-59	219.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,3WGKS@541000|Ruminococcaceae	186801|Clostridia	S	domain protein	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
DEZH2_k127_7559425_2	1392491.JIAE01000001_gene926	1.79e-68	244.0	COG0130@1|root,COG0130@2|Bacteria,1TP9Y@1239|Firmicutes,24B46@186801|Clostridia,3WPHP@541000|Ruminococcaceae	186801|Clostridia	J	tRNA pseudouridylate synthase B C-terminal domain	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
DEZH2_k127_7559425_4	555079.Toce_1233	2.068e-55	207.0	COG0196@1|root,COG0196@2|Bacteria,1TPKS@1239|Firmicutes,2484A@186801|Clostridia,42F98@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
DEZH2_k127_7559425_1	1410638.JHXJ01000028_gene1235	2.335e-72	251.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24APG@186801|Clostridia,3WH7A@541000|Ruminococcaceae	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
DEZH2_k127_7570312_2	1392491.JIAE01000001_gene2541	8.599e-30	122.0	COG0594@1|root,COG0594@2|Bacteria	2|Bacteria	J	ribonuclease P activity	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904	3.1.26.5	ko:K03536,ko:K08998	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
DEZH2_k127_7570312_5	592031.GCWU000322_00651	1.504e-12	68.0	COG0230@1|root,COG0230@2|Bacteria,1VK90@1239|Firmicutes,24UGN@186801|Clostridia,25XP8@186806|Eubacteriaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
DEZH2_k127_7570312_0	720554.Clocl_0948	6.853e-214	691.0	COG1716@1|root,COG1716@2|Bacteria,1TS4P@1239|Firmicutes,24BY6@186801|Clostridia,3WGRR@541000|Ruminococcaceae	186801|Clostridia	T	Clostripain family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C11
DEZH2_k127_7570312_1	1392491.JIAE01000001_gene501	8.687e-48	183.0	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,3WQ5Z@541000|Ruminococcaceae	186801|Clostridia	I	GHMP kinases N terminal domain	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
DEZH2_k127_7570312_3	1392491.JIAE01000001_gene500	1.194e-27	115.0	COG4466@1|root,COG4466@2|Bacteria,1VEQM@1239|Firmicutes,24QN2@186801|Clostridia,3WMGE@541000|Ruminococcaceae	186801|Clostridia	S	Biofilm formation stimulator VEG	veg	-	-	-	-	-	-	-	-	-	-	-	VEG
DEZH2_k127_7570312_4	500635.MITSMUL_04742	4.035e-21	93.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,4H1XW@909932|Negativicutes	909932|Negativicutes	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
DEZH2_k127_7598311_0	1392491.JIAE01000001_gene580	1.608e-155	503.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,3WH2A@541000|Ruminococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
DEZH2_k127_7598311_1	1392491.JIAE01000001_gene579	4.35e-29	120.0	COG1925@1|root,COG1925@2|Bacteria,1TTT1@1239|Firmicutes,24PF9@186801|Clostridia,3WRW6@541000|Ruminococcaceae	186801|Clostridia	G	PTS HPr component phosphorylation site	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
DEZH2_k127_7598311_2	526222.Desal_1934	2.566e-24	107.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,42V77@68525|delta/epsilon subdivisions,2WRQF@28221|Deltaproteobacteria,2MCBQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
DEZH2_k127_7616944_1	1392491.JIAE01000001_gene2539	9.784e-72	247.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,3WHR4@541000|Ruminococcaceae	186801|Clostridia	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
DEZH2_k127_7616944_0	1392491.JIAE01000001_gene2540	1.803e-85	296.0	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,3WHYT@541000|Ruminococcaceae	186801|Clostridia	U	Membrane protein insertase, YidC Oxa1 family	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
DEZH2_k127_7616944_2	1415775.U729_1090	5.092e-27	111.0	COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,24QN4@186801|Clostridia,36MJT@31979|Clostridiaceae	186801|Clostridia	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
DEZH2_k127_765761_0	1392491.JIAE01000001_gene507	7.456e-208	650.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3WGC7@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	msmX	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
DEZH2_k127_765761_2	1392491.JIAE01000001_gene506	4.133e-135	438.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,3WGZJ@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DEZH2_k127_765761_4	720554.Clocl_0492	3.887e-133	430.0	COG0548@1|root,COG0548@2|Bacteria,1TP0N@1239|Firmicutes,2486J@186801|Clostridia,3WGF0@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10565	AA_kinase
DEZH2_k127_765761_3	1410638.JHXJ01000008_gene365	1.064e-134	441.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,3WGQA@541000|Ruminococcaceae	186801|Clostridia	E	acetylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DEZH2_k127_765761_1	1392491.JIAE01000001_gene503	2.649e-151	483.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,3WG9U@541000|Ruminococcaceae	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.6,2.1.3.9	ko:K00611,ko:K09065,ko:K13252	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12430	OTCace,OTCace_N
DEZH2_k127_765761_9	4896.SPBC13E7.02.1	0.0006514	49.0	COG0456@1|root,COG5152@1|root,KOG1813@2759|Eukaryota,KOG3138@2759|Eukaryota,38BQR@33154|Opisthokonta,3NWD2@4751|Fungi,3QSB8@4890|Ascomycota,3MCTU@451866|Taphrinomycotina	4751|Fungi	O	zf-C3HC4 type GCN5-like N acetyltransferase fusion protein	CWC24	GO:0000349,GO:0000375,GO:0000377,GO:0000393,GO:0000398,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005681,GO:0005684,GO:0006139,GO:0006396,GO:0006397,GO:0006464,GO:0006725,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008270,GO:0008380,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016071,GO:0016074,GO:0016407,GO:0016410,GO:0016567,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0019787,GO:0022607,GO:0022613,GO:0022618,GO:0032446,GO:0032991,GO:0034247,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0036211,GO:0043144,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045292,GO:0046483,GO:0046872,GO:0046914,GO:0061630,GO:0061659,GO:0065003,GO:0070647,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1990904	2.3.1.258	ko:K13127,ko:K20793	-	-	-	-	ko00000,ko01000,ko03036,ko03041	-	-	-	zf-C3HC4,zf-C3HC4_2,zf-C3HC4_3,zf-CCCH,zf-RING_UBOX
DEZH2_k127_765761_8	428125.CLOLEP_01832	4.352e-20	98.0	COG1974@1|root,COG1974@2|Bacteria,1V4PJ@1239|Firmicutes,24I0Y@186801|Clostridia,3WJ0J@541000|Ruminococcaceae	186801|Clostridia	K	DNA-binding helix-turn-helix protein	-	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	HTH_3,Peptidase_S24
DEZH2_k127_765761_6	398512.JQKC01000019_gene3498	7.355e-119	390.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,3WGIP@541000|Ruminococcaceae	186801|Clostridia	G	Transketolase, pyridine binding domain protein	tktB	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
DEZH2_k127_765761_7	720554.Clocl_0414	1.217e-117	384.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,3WGJB@541000|Ruminococcaceae	186801|Clostridia	G	Transketolase, thiamine diphosphate binding domain	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
DEZH2_k127_765761_5	1121335.Clst_2406	1.303e-121	399.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,3WGQU@541000|Ruminococcaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
DEZH2_k127_7680441_1	756499.Desde_0492	1.066e-94	312.0	COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,247JX@186801|Clostridia,260V6@186807|Peptococcaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_7680441_0	428125.CLOLEP_03133	2.573e-135	445.0	COG0577@1|root,COG0577@2|Bacteria,1TR2D@1239|Firmicutes,2481J@186801|Clostridia,3WGPM@541000|Ruminococcaceae	186801|Clostridia	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
DEZH2_k127_7683181_3	556261.HMPREF0240_02350	8.39e-21	93.0	COG1695@1|root,COG1695@2|Bacteria,1VESB@1239|Firmicutes,25CVC@186801|Clostridia,36JUB@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
DEZH2_k127_7683181_1	394503.Ccel_2394	9.103e-152	490.0	COG2271@1|root,COG2271@2|Bacteria,1V0WU@1239|Firmicutes,25E6S@186801|Clostridia,36UV5@31979|Clostridiaceae	186801|Clostridia	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
DEZH2_k127_7683181_0	592026.GCWU0000282_001748	3.608e-193	610.0	COG1373@1|root,COG1373@2|Bacteria,1TPFF@1239|Firmicutes,24CP6@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
DEZH2_k127_7683181_2	649639.Bcell_1105	6.008e-32	128.0	COG2207@1|root,COG2207@2|Bacteria,1TQKE@1239|Firmicutes,4HAA2@91061|Bacilli,1ZD9Q@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	ybfP	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019243,GO:0019249,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046185,GO:0046394,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:1901575,GO:1901576,GO:1901615,GO:1901617	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18
DEZH2_k127_7705293_3	1392491.JIAE01000001_gene2478	1.296e-25	108.0	COG0201@1|root,COG0201@2|Bacteria,1TPHB@1239|Firmicutes,248T9@186801|Clostridia,3WG8Z@541000|Ruminococcaceae	186801|Clostridia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
DEZH2_k127_7705293_1	1410638.JHXJ01000008_gene395	1.195e-66	229.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia,3WIV7@541000|Ruminococcaceae	186801|Clostridia	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
DEZH2_k127_7705293_4	588581.Cpap_1350	3.674e-12	69.0	COG1841@1|root,COG1841@2|Bacteria	2|Bacteria	J	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rpmD	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
DEZH2_k127_7705293_0	1392491.JIAE01000001_gene2480	4.304e-79	266.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,24G5D@186801|Clostridia,3WICZ@541000|Ruminococcaceae	186801|Clostridia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
DEZH2_k127_7705293_2	1392491.JIAE01000001_gene2481	8.5e-47	171.0	COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,24JCS@186801|Clostridia,3WJ8R@541000|Ruminococcaceae	186801|Clostridia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
DEZH2_k127_7747797_3	1120746.CCNL01000005_gene316	2.762e-35	139.0	COG0454@1|root,COG0454@2|Bacteria	2|Bacteria	K	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
DEZH2_k127_7747797_2	428125.CLOLEP_03881	2.272e-160	511.0	COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,247SM@186801|Clostridia,3WGD1@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
DEZH2_k127_7747797_6	768706.Desor_2660	5.945e-13	80.0	2BG5B@1|root,32A23@2|Bacteria,1UWCR@1239|Firmicutes,25AP9@186801|Clostridia,26586@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4405)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4405
DEZH2_k127_7747797_0	1392491.JIAE01000001_gene1798	2.727e-186	602.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,3WGHX@541000|Ruminococcaceae	186801|Clostridia	S	ABC transporter	-	-	-	ko:K06158,ko:K19350	ko02010,map02010	-	-	-	ko00000,ko00001,ko01504,ko02000,ko03012	3.A.1.121	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
DEZH2_k127_7747797_1	588581.Cpap_4249	5.833e-165	523.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,3WGNI@541000|Ruminococcaceae	186801|Clostridia	G	Fructose-1,6-bisphosphate aldolase, class II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
DEZH2_k127_7747797_5	742741.HMPREF9475_00487	3.612e-25	109.0	2DNQ7@1|root,32YJ2@2|Bacteria,1VFJY@1239|Firmicutes,24S09@186801|Clostridia,220E6@1506553|Lachnoclostridium	186801|Clostridia	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
DEZH2_k127_7769452_0	1195236.CTER_0809	6.667e-115	374.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,3WG9W@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DEZH2_k127_7769452_2	1410638.JHXJ01000017_gene632	4.596e-94	310.0	COG0423@1|root,COG0423@2|Bacteria,1TP94@1239|Firmicutes,248FB@186801|Clostridia,3WGTU@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
DEZH2_k127_7769452_1	1392491.JIAE01000001_gene586	4.692e-102	334.0	COG0423@1|root,COG0423@2|Bacteria,1TP94@1239|Firmicutes,248FB@186801|Clostridia,3WGTU@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
DEZH2_k127_7776431_3	1499684.CCNP01000015_gene329	8.072e-25	104.0	COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,24833@186801|Clostridia,36ETZ@31979|Clostridiaceae	186801|Clostridia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
DEZH2_k127_7776431_1	1392491.JIAE01000001_gene2492	1.167e-58	207.0	COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,24JF4@186801|Clostridia,3WJ9K@541000|Ruminococcaceae	186801|Clostridia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
DEZH2_k127_7776431_2	1392491.JIAE01000001_gene2493	3.073e-44	162.0	COG0185@1|root,COG0185@2|Bacteria,1V6CX@1239|Firmicutes,24JN3@186801|Clostridia,3WQ1M@541000|Ruminococcaceae	186801|Clostridia	J	Ribosomal protein S19	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
DEZH2_k127_7776431_0	1392491.JIAE01000001_gene2494	3.197e-137	439.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,3WGQK@541000|Ruminococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
DEZH2_k127_7866644_2	386456.JQKN01000016_gene937	9.261e-31	129.0	COG0655@1|root,arCOG02572@2157|Archaea	2157|Archaea	S	NAD(P)H-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DEZH2_k127_7866644_0	994573.T472_0204380	3.397e-132	426.0	COG1657@1|root,COG1657@2|Bacteria,1TPY3@1239|Firmicutes,247MQ@186801|Clostridia,36FZF@31979|Clostridiaceae	186801|Clostridia	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7866644_1	1321778.HMPREF1982_02365	5.553e-65	222.0	COG0388@1|root,COG0388@2|Bacteria,1TRMU@1239|Firmicutes,25B19@186801|Clostridia	186801|Clostridia	S	N-carbamoylputrescine amidase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
DEZH2_k127_7885165_0	573061.Clocel_0518	1.786e-105	352.0	COG1609@1|root,COG1609@2|Bacteria,1TRFH@1239|Firmicutes,24825@186801|Clostridia,36GF4@31979|Clostridiaceae	186801|Clostridia	K	Periplasmic binding protein-like domain	-	-	5.1.1.1	ko:K01775,ko:K02529	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011,ko03000	-	-	-	LacI,Peripla_BP_3
DEZH2_k127_7885165_2	1408437.JNJN01000071_gene1633	4.278e-42	157.0	COG0346@1|root,COG0346@2|Bacteria,1V4NM@1239|Firmicutes,24HFS@186801|Clostridia,25X0Y@186806|Eubacteriaceae	186801|Clostridia	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
DEZH2_k127_7885165_1	717606.PaecuDRAFT_3497	9.089e-58	211.0	COG0500@1|root,COG2226@2|Bacteria,1VIXJ@1239|Firmicutes,4HGT9@91061|Bacilli,277H6@186822|Paenibacillaceae	91061|Bacilli	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
DEZH2_k127_7885165_3	1410650.JHWL01000014_gene539	2.405e-07	55.0	COG1198@1|root,COG1198@2|Bacteria	2|Bacteria	L	DNA replication, synthesis of RNA primer	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
DEZH2_k127_7910711_1	273068.TTE2214	1.23e-15	88.0	COG1721@1|root,COG1721@2|Bacteria,1VA48@1239|Firmicutes,24E5S@186801|Clostridia,42G7S@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
DEZH2_k127_7910711_0	448385.sce1744	8.486e-45	166.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2YU45@29|Myxococcales	28221|Deltaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
DEZH2_k127_792456_1	658086.HMPREF0994_01237	1.48e-57	205.0	COG5340@1|root,COG5340@2|Bacteria,1USGA@1239|Firmicutes,24IEV@186801|Clostridia,27M2B@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Transcriptional regulator, AbiEi antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4
DEZH2_k127_792456_0	398512.JQKC01000001_gene2236	1.106e-66	231.0	COG3695@1|root,COG3695@2|Bacteria,1TPJI@1239|Firmicutes,249H6@186801|Clostridia,3WJHS@541000|Ruminococcaceae	186801|Clostridia	L	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
DEZH2_k127_792456_2	1410668.JNKC01000014_gene2487	5.508e-44	177.0	2DQ9N@1|root,335H9@2|Bacteria,1VIEN@1239|Firmicutes,24SYA@186801|Clostridia	186801|Clostridia	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
DEZH2_k127_792456_3	1410668.JNKC01000014_gene2486	2.119e-16	82.0	COG1595@1|root,COG1595@2|Bacteria,1UZSS@1239|Firmicutes,24GQJ@186801|Clostridia,36JMG@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DEZH2_k127_7940249_1	269797.Mbar_A1995	2.545e-83	292.0	arCOG02516@1|root,arCOG02538@1|root,arCOG02516@2157|Archaea,arCOG02538@2157|Archaea,2Y7RK@28890|Euryarchaeota,2NBKX@224756|Methanomicrobia	2157|Archaea	S	Leucine rich repeats (6 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,He_PIG,PKD,PQQ_3,Peptidase_S8,S-layer
DEZH2_k127_7940249_5	1280668.ATVT01000001_gene722	3.463e-05	54.0	2F8IA@1|root,340X3@2|Bacteria,1VX53@1239|Firmicutes,252AF@186801|Clostridia,4BYJ2@830|Butyrivibrio	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7940249_0	479437.Elen_1701	1.723e-211	672.0	COG0365@1|root,COG0365@2|Bacteria,2GJSQ@201174|Actinobacteria,4CUFZ@84998|Coriobacteriia	84998|Coriobacteriia	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
DEZH2_k127_7940249_3	203119.Cthe_0552	9.803e-50	183.0	COG1917@1|root,COG1917@2|Bacteria,1V26G@1239|Firmicutes,24GYR@186801|Clostridia,3WIJ4@541000|Ruminococcaceae	186801|Clostridia	K	PFAM Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_19,HTH_3
DEZH2_k127_7940249_2	293826.Amet_2172	1.49e-82	286.0	COG2199@1|root,COG3829@1|root,COG3706@2|Bacteria,COG3829@2|Bacteria,1VB8N@1239|Firmicutes,25EJ3@186801|Clostridia	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
DEZH2_k127_7940249_4	394503.Ccel_0640	3.66e-40	159.0	COG0775@1|root,COG0775@2|Bacteria,1VCJY@1239|Firmicutes,24CRR@186801|Clostridia,36E12@31979|Clostridiaceae	186801|Clostridia	F	PFAM purine or other phosphorylase family 1	-	-	-	-	-	-	-	-	-	-	-	-	PNP_UDP_1
DEZH2_k127_7941830_1	1392491.JIAE01000001_gene1507	3.06e-125	404.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,3WGAU@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
DEZH2_k127_7941830_0	1410638.JHXJ01000013_gene2297	2.172e-155	497.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,3WGMR@541000|Ruminococcaceae	186801|Clostridia	H	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
DEZH2_k127_7941830_2	1392491.JIAE01000001_gene1505	6.594e-117	383.0	COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,247T5@186801|Clostridia,3WGWA@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS02100	DHDPS
DEZH2_k127_7941830_3	1410638.JHXJ01000002_gene1405	3.537e-80	274.0	COG0289@1|root,COG0289@2|Bacteria,1TR9D@1239|Firmicutes,248FY@186801|Clostridia,3WH3Y@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17035	DapB_C,DapB_N
DEZH2_k127_7941830_4	1121335.Clst_1143	5.048e-23	110.0	COG5578@1|root,COG5578@2|Bacteria,1V87X@1239|Firmicutes,24J7V@186801|Clostridia,3WJA5@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function, DUF624	-	-	-	-	-	-	-	-	-	-	-	-	DUF624
DEZH2_k127_7941830_5	1304880.JAGB01000001_gene53	6.455e-14	73.0	COG1206@1|root,COG1206@2|Bacteria,1TP67@1239|Firmicutes,24971@186801|Clostridia	186801|Clostridia	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
DEZH2_k127_7947030_1	1123487.KB892835_gene3423	1.011e-60	212.0	COG0673@1|root,COG0673@2|Bacteria,1MVVF@1224|Proteobacteria,2VNI2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DEZH2_k127_7947030_0	1161902.HMPREF0378_0730	1.716e-88	297.0	COG1131@1|root,COG1131@2|Bacteria,1V1P4@1239|Firmicutes,249VI@186801|Clostridia	186801|Clostridia	V	Abc transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_7947030_3	1385512.N784_02775	2.248e-21	109.0	2F5WY@1|root,33YFN@2|Bacteria,1VXY0@1239|Firmicutes,4HX9C@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7947030_2	883081.HMPREF9698_01240	1.108e-41	163.0	2EFXP@1|root,339PX@2|Bacteria,1VMW2@1239|Firmicutes,4HS2J@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7947030_4	1134413.ANNK01000142_gene3040	5.114e-09	58.0	2A18T@1|root,30PF7@2|Bacteria,1TXQG@1239|Firmicutes,4I6RR@91061|Bacilli,1ZNFC@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7985883_0	857293.CAAU_0145	1.967e-181	575.0	COG2115@1|root,COG2115@2|Bacteria,1TQW2@1239|Firmicutes,24869@186801|Clostridia,36EXR@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the xylose isomerase family	xylA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08960	AP_endonuc_2
DEZH2_k127_7987901_0	1408312.JNJS01000004_gene2249	8.929e-97	332.0	COG4099@1|root,COG4099@2|Bacteria,1TRER@1239|Firmicutes,2492V@186801|Clostridia	186801|Clostridia	G	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,BAAT_C
DEZH2_k127_7987901_2	768710.DesyoDRAFT_4726	1.74e-20	93.0	2EH1M@1|root,33ATM@2|Bacteria,1VM89@1239|Firmicutes,24WBS@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_7987901_1	370438.PTH_2358	1.678e-68	241.0	COG3527@1|root,COG3527@2|Bacteria,1V4AH@1239|Firmicutes,24FY1@186801|Clostridia	186801|Clostridia	Q	Alpha-acetolactate decarboxylase	alsD	-	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660	-	R02948	RC00812	ko00000,ko00001,ko01000	-	-	-	AAL_decarboxy,Peptidase_M15
DEZH2_k127_7987901_3	1280668.ATVT01000006_gene1440	1.679e-19	90.0	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,24A5F@186801|Clostridia,4C19E@830|Butyrivibrio	186801|Clostridia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
DEZH2_k127_8028889_0	349161.Dred_2232	0.0	1657.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,24819@186801|Clostridia,260WM@186807|Peptococcaceae	186801|Clostridia	EF	Belongs to the CarB family	carB2	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
DEZH2_k127_8028889_1	1392491.JIAE01000001_gene328	1.037e-58	203.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,3WGI1@541000|Ruminococcaceae	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
DEZH2_k127_8046006_4	484770.UFO1_0437	0.0002207	45.0	COG5495@1|root,COG5495@2|Bacteria,1UZZU@1239|Firmicutes,4H47T@909932|Negativicutes	909932|Negativicutes	S	Domain of unknown function (DUF2520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,F420_oxidored,Rossmann-like
DEZH2_k127_8046006_1	1392491.JIAE01000001_gene565	3.537e-80	274.0	COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia,3WH6T@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
DEZH2_k127_8046006_3	755731.Clo1100_0663	1.695e-27	129.0	COG2173@1|root,COG3786@1|root,COG2173@2|Bacteria,COG3786@2|Bacteria,1VAFK@1239|Firmicutes,24P72@186801|Clostridia,36J31@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15,YkuD
DEZH2_k127_8046006_2	411463.EUBVEN_02680	9.856e-69	252.0	28UKF@1|root,2ZGQZ@2|Bacteria,1UI2G@1239|Firmicutes,25EB1@186801|Clostridia,25W2T@186806|Eubacteriaceae	186801|Clostridia	S	SGNH hydrolase-like domain, acetyltransferase AlgX	-	-	-	-	-	-	-	-	-	-	-	-	ALGX
DEZH2_k127_8046006_0	97139.C824_02008	2.694e-80	275.0	COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,248V4@186801|Clostridia,36DV2@31979|Clostridiaceae	186801|Clostridia	M	membrane protein involved in D-alanine export	-	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
DEZH2_k127_8047611_1	203119.Cthe_3097	6.234e-80	274.0	COG1215@1|root,COG1215@2|Bacteria,1UI5W@1239|Firmicutes,25EJ5@186801|Clostridia,3WSJE@541000|Ruminococcaceae	186801|Clostridia	M	Family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
DEZH2_k127_8047611_0	1449050.JNLE01000003_gene867	4.378e-126	411.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia,36DR8@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
DEZH2_k127_8047611_2	591001.Acfer_1242	1.554e-61	223.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,4H2G0@909932|Negativicutes	909932|Negativicutes	S	Flavoprotein family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
DEZH2_k127_8062803_1	428125.CLOLEP_01561	2.272e-131	426.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,3WGJQ@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
DEZH2_k127_8062803_0	1392491.JIAE01000001_gene1069	3.91e-286	885.0	COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,247Y0@186801|Clostridia,3WH6G@541000|Ruminococcaceae	186801|Clostridia	J	glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
DEZH2_k127_8062803_2	1392491.JIAE01000001_gene1064	1.253e-70	246.0	COG2017@1|root,COG2017@2|Bacteria,1TQGJ@1239|Firmicutes,249DZ@186801|Clostridia,3WP3E@541000|Ruminococcaceae	186801|Clostridia	G	Aldose 1-epimerase	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
DEZH2_k127_8099801_3	1410638.JHXJ01000011_gene690	7.283e-27	113.0	COG1123@1|root,COG4172@2|Bacteria,1UZK8@1239|Firmicutes,2511Z@186801|Clostridia,3WRDF@541000|Ruminococcaceae	186801|Clostridia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
DEZH2_k127_8099801_2	1410638.JHXJ01000011_gene691	1.718e-84	288.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,3WJDM@541000|Ruminococcaceae	186801|Clostridia	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
DEZH2_k127_8099801_1	1410638.JHXJ01000011_gene692	1.635e-106	353.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,3WK10@541000|Ruminococcaceae	186801|Clostridia	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
DEZH2_k127_8099801_0	1410638.JHXJ01000011_gene693	1.467e-132	433.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,3WK3M@541000|Ruminococcaceae	186801|Clostridia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
DEZH2_k127_810380_2	796942.HMPREF9623_01233	3.857e-91	317.0	COG4676@1|root,COG4676@2|Bacteria,1VF8Z@1239|Firmicutes,24S72@186801|Clostridia	186801|Clostridia	V	antibiotic catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TPR_11
DEZH2_k127_810380_4	658086.HMPREF0994_06005	1.032e-47	176.0	COG1827@1|root,COG1827@2|Bacteria,1V6EY@1239|Firmicutes,24JF2@186801|Clostridia,27MN7@186928|unclassified Lachnospiraceae	186801|Clostridia	S	3H domain	niaR	-	-	ko:K07105	-	-	-	-	ko00000	-	-	-	3H,HTH_11
DEZH2_k127_810380_1	1280696.ATVY01000025_gene1340	2.375e-107	356.0	COG0157@1|root,COG0157@2|Bacteria,1TPQC@1239|Firmicutes,248P2@186801|Clostridia,4BYRJ@830|Butyrivibrio	186801|Clostridia	H	Quinolinate phosphoribosyl transferase, C-terminal domain	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12010	QRPTase_C,QRPTase_N
DEZH2_k127_810380_0	1120998.AUFC01000004_gene2346	5.137e-189	599.0	COG0029@1|root,COG0029@2|Bacteria,1UHSP@1239|Firmicutes,25E6F@186801|Clostridia,3WDU2@538999|Clostridiales incertae sedis	186801|Clostridia	H	FAD binding domain	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
DEZH2_k127_810380_5	1151292.QEW_1865	2.362e-42	161.0	COG1896@1|root,COG1896@2|Bacteria,1UIAE@1239|Firmicutes,25EFH@186801|Clostridia	186801|Clostridia	S	HD domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
DEZH2_k127_810380_3	158190.SpiGrapes_1536	3.959e-60	216.0	COG2199@1|root,COG3706@2|Bacteria,2J7K5@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
DEZH2_k127_8144291_1	555088.DealDRAFT_2878	1.758e-16	87.0	COG1309@1|root,COG1309@2|Bacteria,1V2EH@1239|Firmicutes,24H5Z@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
DEZH2_k127_8144291_0	1487921.DP68_17580	6.482e-84	285.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,36EK4@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_8157709_3	511680.BUTYVIB_01140	3.982e-99	328.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,24969@186801|Clostridia,4BW1X@830|Butyrivibrio	186801|Clostridia	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DEZH2_k127_8157709_1	1105031.HMPREF1141_1649	6.497e-246	770.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,36DBK@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
DEZH2_k127_8157709_0	357809.Cphy_0812	1.266e-257	819.0	COG0747@1|root,COG0747@2|Bacteria,1TSBC@1239|Firmicutes,24B65@186801|Clostridia	186801|Clostridia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
DEZH2_k127_8157709_2	357809.Cphy_0813	4.257e-154	492.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,21Z5S@1506553|Lachnoclostridium	186801|Clostridia	P	COG COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	appB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
DEZH2_k127_8157709_4	357809.Cphy_0814	1.414e-46	174.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,21YKJ@1506553|Lachnoclostridium	186801|Clostridia	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N,RCC1_2
DEZH2_k127_8158595_1	357809.Cphy_0814	1.099e-166	537.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,21YKJ@1506553|Lachnoclostridium	186801|Clostridia	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N,RCC1_2
DEZH2_k127_8158595_0	357809.Cphy_0815	2.643e-178	565.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,21ZE9@1506553|Lachnoclostridium	186801|Clostridia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	appD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
DEZH2_k127_8158595_2	994573.T472_0213210	1.541e-78	267.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,36EGD@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
DEZH2_k127_8210781_3	556261.HMPREF0240_01691	2.369e-08	57.0	COG0604@1|root,COG0604@2|Bacteria,1TT5J@1239|Firmicutes,24IEA@186801|Clostridia,36KEU@31979|Clostridiaceae	186801|Clostridia	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8210781_2	268407.PWYN_24095	1.656e-56	201.0	COG1476@1|root,COG1476@2|Bacteria,1VS87@1239|Firmicutes	1239|Firmicutes	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
DEZH2_k127_8210781_1	994573.T472_0207760	1.765e-90	324.0	COG3463@1|root,COG3463@2|Bacteria,1UXXA@1239|Firmicutes,24CH2@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2079
DEZH2_k127_8210781_0	398512.JQKC01000027_gene3921	2.334e-100	332.0	COG0641@1|root,COG0641@2|Bacteria,1V5ZZ@1239|Firmicutes,24IY0@186801|Clostridia,3WRPY@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM superfamily	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
DEZH2_k127_8238159_2	1280668.ATVT01000001_gene785	8.336e-32	139.0	COG1653@1|root,COG1653@2|Bacteria,1V4Z6@1239|Firmicutes,24FVZ@186801|Clostridia,4BW4C@830|Butyrivibrio	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
DEZH2_k127_8238159_0	509191.AEDB02000094_gene4308	2.013e-109	368.0	COG0454@1|root,COG1600@1|root,COG0456@2|Bacteria,COG1600@2|Bacteria,1V4QC@1239|Firmicutes,24J5M@186801|Clostridia,3WK6Y@541000|Ruminococcaceae	186801|Clostridia	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
DEZH2_k127_8238159_1	445972.ANACOL_00320	4.393e-107	354.0	COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,247Q2@186801|Clostridia,3WG7F@541000|Ruminococcaceae	186801|Clostridia	P	Metal cation transporter, ZIP family	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
DEZH2_k127_8263944_1	1392491.JIAE01000001_gene1195	2.548e-100	328.0	COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,249DV@186801|Clostridia,3WGN8@541000|Ruminococcaceae	186801|Clostridia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
DEZH2_k127_8263944_2	1392491.JIAE01000001_gene1442	9.965e-35	140.0	COG2179@1|root,COG2179@2|Bacteria,1V6KM@1239|Firmicutes,24KK7@186801|Clostridia,3WJJ3@541000|Ruminococcaceae	186801|Clostridia	S	HAD superfamily (Subfamily IIIA) phosphatase, TIGR01668	yqeG	-	-	ko:K07015	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase,Hydrolase_like,PGP_phosphatase
DEZH2_k127_8263944_0	509191.AEDB02000066_gene746	7.708e-134	439.0	COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,3WHC9@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the aspartokinase family	thrA	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
DEZH2_k127_8267733_1	237609.PSAKL28_39390	7.48e-06	52.0	COG1396@1|root,COG1396@2|Bacteria,1N721@1224|Proteobacteria,1SYKG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
DEZH2_k127_8267733_0	1392491.JIAE01000001_gene2344	5.103e-105	359.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	lacM	-	3.2.1.23,3.2.1.35,3.2.1.51,3.2.1.97	ko:K01190,ko:K01197,ko:K01206,ko:K17624	ko00052,ko00511,ko00531,ko00600,ko01100,map00052,map00511,map00531,map00600,map01100	M00076,M00077	R01105,R01678,R03355,R04783,R06114,R07824,R07825,R10905	RC00049,RC00452	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042,ko04147	-	GH101,GH29	-	Bgal_small_N,DUF5011,F5_F8_type_C,Glyco_hydro_2_C,NPCBM,Peptidase_M60
DEZH2_k127_8289973_0	1392491.JIAE01000001_gene383	5.062e-319	987.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia,3WGA7@541000|Ruminococcaceae	186801|Clostridia	J	translation elongation	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DEZH2_k127_8289973_1	1392491.JIAE01000001_gene384	7.596e-170	559.0	COG5427@1|root,COG5427@2|Bacteria,1UXXM@1239|Firmicutes,24EF9@186801|Clostridia,3WHFN@541000|Ruminococcaceae	186801|Clostridia	M	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8289973_2	203119.Cthe_3097	4.405e-77	264.0	COG1215@1|root,COG1215@2|Bacteria,1UI5W@1239|Firmicutes,25EJ5@186801|Clostridia,3WSJE@541000|Ruminococcaceae	186801|Clostridia	M	Family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
DEZH2_k127_8304626_1	160799.PBOR_17635	1.197e-98	345.0	COG0577@1|root,COG0577@2|Bacteria,1TQ3S@1239|Firmicutes,4HTWY@91061|Bacilli,26W1Q@186822|Paenibacillaceae	91061|Bacilli	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
DEZH2_k127_8304626_2	394503.Ccel_1421	5.153e-42	159.0	COG2314@1|root,COG2314@2|Bacteria,1VCBB@1239|Firmicutes,24IJ6@186801|Clostridia,36NQ9@31979|Clostridiaceae	186801|Clostridia	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
DEZH2_k127_8304626_0	755731.Clo1100_1193	3.319e-139	451.0	COG4260@1|root,COG4260@2|Bacteria,1TRYU@1239|Firmicutes,24901@186801|Clostridia,36GFC@31979|Clostridiaceae	186801|Clostridia	L	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,zinc_ribbon_2
DEZH2_k127_8309706_1	588581.Cpap_1657	2.043e-120	392.0	COG0451@1|root,COG0451@2|Bacteria,1TPYA@1239|Firmicutes,24A39@186801|Clostridia,3WHQG@541000|Ruminococcaceae	186801|Clostridia	GM	NAD dependent epimerase dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
DEZH2_k127_8309706_0	1123009.AUID01000030_gene1359	2.155e-158	511.0	COG0659@1|root,COG0659@2|Bacteria,1TPI4@1239|Firmicutes,24978@186801|Clostridia,268H8@186813|unclassified Clostridiales	186801|Clostridia	P	Sulfate permease family	sulP	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
DEZH2_k127_8317154_4	1160721.RBI_I01793	2.419e-07	61.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
DEZH2_k127_8317154_2	1304880.JAGB01000002_gene1807	2.888e-105	350.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia	186801|Clostridia	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
DEZH2_k127_8317154_0	1392491.JIAE01000001_gene315	3.772e-189	620.0	COG1368@1|root,COG1368@2|Bacteria,1TRMA@1239|Firmicutes,2480C@186801|Clostridia,3WGV3@541000|Ruminococcaceae	186801|Clostridia	M	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
DEZH2_k127_8317154_1	1410638.JHXJ01000004_gene2057	5.841e-132	432.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,3WRRS@541000|Ruminococcaceae	186801|Clostridia	L	helicase superfamily c-terminal domain	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
DEZH2_k127_8317154_3	1415774.U728_631	5.547e-10	64.0	COG0457@1|root,COG0457@2|Bacteria,1V5AR@1239|Firmicutes,24VKU@186801|Clostridia	186801|Clostridia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8405419_0	1392491.JIAE01000001_gene2429	6.099e-87	302.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,3WH0E@541000|Ruminococcaceae	186801|Clostridia	O	Trypsin-like serine proteases typically periplasmic contain C-terminal PDZ domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
DEZH2_k127_8405419_2	1392491.JIAE01000001_gene2430	2.528e-48	181.0	COG1739@1|root,COG1739@2|Bacteria,1V6MQ@1239|Firmicutes,248W7@186801|Clostridia,3WIHN@541000|Ruminococcaceae	186801|Clostridia	S	YigZ family	yvyE	-	-	-	-	-	-	-	-	-	-	-	DUF1949,UPF0029
DEZH2_k127_8405419_1	394503.Ccel_0179	1.552e-50	183.0	COG0494@1|root,COG0494@2|Bacteria,1UIUD@1239|Firmicutes,25ES6@186801|Clostridia,36JD6@31979|Clostridiaceae	186801|Clostridia	L	pfam nudix	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
DEZH2_k127_841713_3	1392491.JIAE01000001_gene2506	1.546e-58	210.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,3WIH7@541000|Ruminococcaceae	186801|Clostridia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
DEZH2_k127_841713_0	1392491.JIAE01000001_gene2507	2.535e-127	409.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,247JB@186801|Clostridia,3WH4A@541000|Ruminococcaceae	186801|Clostridia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
DEZH2_k127_841713_2	699246.HMPREF0868_1275	1.674e-72	246.0	COG0080@1|root,COG0080@2|Bacteria,1V1BS@1239|Firmicutes,24FSQ@186801|Clostridia,268Y4@186813|unclassified Clostridiales	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
DEZH2_k127_841713_1	699246.HMPREF0868_1276	4.517e-77	261.0	COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,248XB@186801|Clostridia,26860@186813|unclassified Clostridiales	186801|Clostridia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
DEZH2_k127_843146_0	1392491.JIAE01000001_gene1911	4.033e-192	610.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,3WGUC@541000|Ruminococcaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
DEZH2_k127_843146_1	945713.IALB_0221	1.246e-106	353.0	COG2326@1|root,COG2326@2|Bacteria	2|Bacteria	S	polyphosphate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
DEZH2_k127_843146_2	1121344.JHZO01000001_gene308	0.000176	44.0	COG1207@1|root,COG1207@2|Bacteria,1UHDT@1239|Firmicutes,25Q4M@186801|Clostridia,3WH51@541000|Ruminococcaceae	186801|Clostridia	M	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
DEZH2_k127_8448656_2	796940.HMPREF9628_01187	1.953e-09	63.0	2ESIJ@1|root,33K39@2|Bacteria,1VP26@1239|Firmicutes,24C1I@186801|Clostridia	186801|Clostridia	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
DEZH2_k127_8448656_1	1392491.JIAE01000001_gene2438	6.008e-119	402.0	COG2720@1|root,COG2720@2|Bacteria,1TSH8@1239|Firmicutes,2493X@186801|Clostridia,3WRXM@541000|Ruminococcaceae	186801|Clostridia	V	VanW like protein	-	-	-	ko:K18346	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01504	-	-	-	G5,PG_binding_4,VanW
DEZH2_k127_8448656_0	1121335.Clst_1985	3.464e-156	501.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,3WGBI@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
DEZH2_k127_8458340_2	645991.Sgly_1449	7.405e-33	143.0	28IHZ@1|root,2Z8J5@2|Bacteria,1TQV6@1239|Firmicutes,249TE@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8458340_1	1280692.AUJL01000002_gene2745	9.24e-81	276.0	COG1131@1|root,COG1131@2|Bacteria,1TRTC@1239|Firmicutes,2488R@186801|Clostridia,36H1E@31979|Clostridiaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_8458340_0	1121333.JMLH01000107_gene13	2.008e-114	402.0	COG1876@1|root,COG4412@1|root,COG5492@1|root,COG1876@2|Bacteria,COG4412@2|Bacteria,COG5492@2|Bacteria,1V38C@1239|Firmicutes,3VSZQ@526524|Erysipelotrichia	526524|Erysipelotrichia	N	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,ChW,Glug
DEZH2_k127_8458340_3	537013.CLOSTMETH_02264	4.151e-21	94.0	COG2197@1|root,COG2197@2|Bacteria,1TW4Y@1239|Firmicutes,25B3S@186801|Clostridia,3WS80@541000|Ruminococcaceae	186801|Clostridia	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DEZH2_k127_8488356_0	1392491.JIAE01000001_gene2053	2.723e-146	479.0	COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,2484K@186801|Clostridia,3WGQ1@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
DEZH2_k127_8488356_1	1195236.CTER_3693	1.588e-78	268.0	COG2364@1|root,COG2364@2|Bacteria,1V7I4@1239|Firmicutes,24IYE@186801|Clostridia,3WID6@541000|Ruminococcaceae	186801|Clostridia	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	YitT_membrane
DEZH2_k127_8488356_3	1121334.KB911069_gene1768	2.259e-46	169.0	COG0393@1|root,COG0393@2|Bacteria,1VADM@1239|Firmicutes,24NFX@186801|Clostridia,3WK63@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
DEZH2_k127_8488356_5	8010.XP_010894384.1	9.994e-37	144.0	COG0503@1|root,KOG1712@2759|Eukaryota,39WRW@33154|Opisthokonta,3BJBR@33208|Metazoa,3D4AR@33213|Bilateria,4814V@7711|Chordata,498S8@7742|Vertebrata,49UZJ@7898|Actinopterygii	33208|Metazoa	F	Zgc 174895	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
DEZH2_k127_8488356_4	398512.JQKC01000007_gene1054	3.048e-41	158.0	COG0716@1|root,COG0716@2|Bacteria,1VFBM@1239|Firmicutes,24RW5@186801|Clostridia	186801|Clostridia	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
DEZH2_k127_8488356_2	1163671.JAGI01000002_gene2522	1.99e-78	264.0	COG0330@1|root,COG0330@2|Bacteria,1UY1Y@1239|Firmicutes,24C8M@186801|Clostridia,36E6J@31979|Clostridiaceae	186801|Clostridia	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
DEZH2_k127_8506232_8	1105031.HMPREF1141_1631	4.583e-38	143.0	COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,24827@186801|Clostridia,36FAN@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
DEZH2_k127_8506232_7	877411.JMMA01000002_gene905	1.035e-106	353.0	COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,2493V@186801|Clostridia,3WHCY@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
DEZH2_k127_8506232_0	1121334.KB911069_gene1701	1.763e-241	748.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,24AHW@186801|Clostridia,3WGMN@541000|Ruminococcaceae	186801|Clostridia	E	Saccharopine dehydrogenase	LYS1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
DEZH2_k127_8506232_2	693746.OBV_12690	4.687e-171	543.0	COG0019@1|root,COG0019@2|Bacteria,1TPQI@1239|Firmicutes,248NH@186801|Clostridia,2N867@216572|Oscillospiraceae	186801|Clostridia	E	Pyridoxal-dependent decarboxylase, C-terminal sheet domain	nspC	-	4.1.1.96	ko:K13747	ko00330,ko01100,map00330,map01100	-	R09081,R09082	RC00299	ko00000,ko00001,ko01000	-	-	-	Orn_DAP_Arg_deC
DEZH2_k127_8506232_3	1123075.AUDP01000051_gene101	1.169e-165	531.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,3WHY8@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
DEZH2_k127_8506232_6	1449050.JNLE01000003_gene1723	2.117e-118	394.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,36W7H@31979|Clostridiaceae	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
DEZH2_k127_8506232_5	1195236.CTER_4466	4.957e-131	430.0	COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia,3WIA6@541000|Ruminococcaceae	186801|Clostridia	S	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	AATase
DEZH2_k127_8506232_9	1304866.K413DRAFT_5266	9.389e-34	138.0	COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia,36FWR@31979|Clostridiaceae	186801|Clostridia	I	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	AATase
DEZH2_k127_8506232_1	1410609.JHVB01000009_gene576	9.017e-220	692.0	COG1070@1|root,COG1070@2|Bacteria,2J5M1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
DEZH2_k127_8506232_4	1384066.JAGT01000001_gene891	4.054e-133	427.0	COG2115@1|root,COG2115@2|Bacteria,1TQW2@1239|Firmicutes,24869@186801|Clostridia,3WGPC@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the xylose isomerase family	xylA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08960	AP_endonuc_2
DEZH2_k127_8511392_1	1195236.CTER_5054	0.0	1238.0	COG0574@1|root,COG0574@2|Bacteria,1TW0W@1239|Firmicutes,248VM@186801|Clostridia,3WHMD@541000|Ruminococcaceae	186801|Clostridia	G	PFAM Pyruvate phosphate dikinase, PEP	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N,Response_reg
DEZH2_k127_8511392_0	1410638.JHXJ01000032_gene258	0.0	1730.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,2498I@186801|Clostridia,3WG9X@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,DAP_epimerase,MGS
DEZH2_k127_8511392_2	1282887.AUJG01000010_gene1312	1.059e-42	160.0	COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,247Q8@186801|Clostridia	186801|Clostridia	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
DEZH2_k127_851276_1	907348.TresaDRAFT_1691	4.007e-73	249.0	COG3833@1|root,COG3833@2|Bacteria,2J6AB@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K15772	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
DEZH2_k127_851276_0	642492.Clole_0693	6.686e-278	869.0	COG1874@1|root,COG1874@2|Bacteria,1TSHK@1239|Firmicutes,249IJ@186801|Clostridia	186801|Clostridia	G	beta-galactosidase	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_35,Glyco_hydro_98M,NPCBM
DEZH2_k127_851276_2	526218.Sterm_0781	1.255e-29	126.0	COG2249@1|root,COG2249@2|Bacteria	2|Bacteria	K	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_2
DEZH2_k127_851276_3	1293054.HSACCH_02590	1.519e-09	62.0	COG0655@1|root,COG0655@2|Bacteria,1TRKM@1239|Firmicutes,24AD6@186801|Clostridia,3WAXS@53433|Halanaerobiales	186801|Clostridia	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_2,SCP2
DEZH2_k127_8538257_2	1511.CLOST_0320	4.275e-25	108.0	COG1704@1|root,COG1704@2|Bacteria,1V3Z0@1239|Firmicutes,24IH4@186801|Clostridia	186801|Clostridia	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
DEZH2_k127_8538257_1	411902.CLOBOL_00101	5.157e-55	211.0	2ECZX@1|root,336WX@2|Bacteria,1VISD@1239|Firmicutes,24QT1@186801|Clostridia	186801|Clostridia	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
DEZH2_k127_8538257_0	1345695.CLSA_c21450	2.924e-120	409.0	COG3275@1|root,COG3437@1|root,COG3275@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD_5,PAS,PAS_4
DEZH2_k127_8572250_0	1392491.JIAE01000001_gene367	3.071e-134	435.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3WGJP@541000|Ruminococcaceae	186801|Clostridia	S	CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
DEZH2_k127_8572250_2	1392491.JIAE01000001_gene368	2.113e-50	187.0	COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,24GK6@186801|Clostridia,3WKSV@541000|Ruminococcaceae	186801|Clostridia	S	HAD-hyrolase-like	ppaX	-	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
DEZH2_k127_8572250_3	1232453.BAIF02000004_gene1566	6.062e-10	72.0	COG0760@1|root,COG0760@2|Bacteria,1V9V9@1239|Firmicutes,25D72@186801|Clostridia,26CI9@186813|unclassified Clostridiales	186801|Clostridia	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase_2
DEZH2_k127_8572250_1	699246.HMPREF0868_0195	1.141e-66	229.0	COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,267SB@186813|unclassified Clostridiales	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
DEZH2_k127_8599602_0	555088.DealDRAFT_1554	5.597e-194	630.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,42K9M@68298|Syntrophomonadaceae	186801|Clostridia	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C,AP_endonuc_2
DEZH2_k127_8599602_2	1392491.JIAE01000001_gene405	7.525e-64	230.0	COG1876@1|root,COG1876@2|Bacteria,1V1F7@1239|Firmicutes,24E6R@186801|Clostridia,3WRN7@541000|Ruminococcaceae	186801|Clostridia	M	D-alanyl-D-alanine carboxypeptidase	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	DUF348,G5,VanY
DEZH2_k127_8599602_1	1392491.JIAE01000001_gene405	5.28e-79	273.0	COG1876@1|root,COG1876@2|Bacteria,1V1F7@1239|Firmicutes,24E6R@186801|Clostridia,3WRN7@541000|Ruminococcaceae	186801|Clostridia	M	D-alanyl-D-alanine carboxypeptidase	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	DUF348,G5,VanY
DEZH2_k127_8599602_3	1410638.JHXJ01000001_gene1887	2.237e-10	65.0	COG3601@1|root,COG3601@2|Bacteria,1V4BW@1239|Firmicutes,24E4V@186801|Clostridia,3WI1Y@541000|Ruminococcaceae	186801|Clostridia	S	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins	ribU	-	-	-	-	-	-	-	-	-	-	-	ECF_trnsprt
DEZH2_k127_862091_0	1392491.JIAE01000001_gene2391	6.595e-75	259.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia,3WG8G@541000|Ruminococcaceae	186801|Clostridia	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
DEZH2_k127_862091_5	1392491.JIAE01000001_gene2392	6.183e-48	181.0	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,3WINW@541000|Ruminococcaceae	186801|Clostridia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.40,2.7.7.60	ko:K00991,ko:K21030	ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130	M00096	R02921,R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS20335	IspD
DEZH2_k127_862091_4	203119.Cthe_2946	1.008e-50	185.0	COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,3WITA@541000|Ruminococcaceae	186801|Clostridia	H	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
DEZH2_k127_862091_7	999415.HMPREF9943_00747	3.361e-05	53.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,3VRMA@526524|Erysipelotrichia	526524|Erysipelotrichia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
DEZH2_k127_862091_2	1392491.JIAE01000001_gene2398	6.783e-61	216.0	COG2813@1|root,COG2813@2|Bacteria,1V1BG@1239|Firmicutes,24KC2@186801|Clostridia,3WJFC@541000|Ruminococcaceae	186801|Clostridia	J	Lysine methyltransferase	-	-	2.1.1.172	ko:K00564	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS
DEZH2_k127_862091_6	1507.HMPREF0262_02947	7.691e-30	126.0	COG4708@1|root,COG4708@2|Bacteria,1V9YK@1239|Firmicutes,24N9H@186801|Clostridia,36HY4@31979|Clostridiaceae	186801|Clostridia	S	membrane	queT	-	-	-	-	-	-	-	-	-	-	-	QueT
DEZH2_k127_862091_3	1347392.CCEZ01000049_gene1363	8.527e-57	209.0	COG5523@1|root,COG5523@2|Bacteria,1V6FC@1239|Firmicutes,24JPX@186801|Clostridia,36WXQ@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF975)	-	-	-	-	-	-	-	-	-	-	-	-	DUF975
DEZH2_k127_862091_1	1282887.AUJG01000001_gene1899	1.868e-68	248.0	COG0584@1|root,COG0584@2|Bacteria,1UGF1@1239|Firmicutes,25E4R@186801|Clostridia	186801|Clostridia	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD,GPDPase_memb
DEZH2_k127_8657675_3	1392491.JIAE01000001_gene334	1.526e-109	361.0	COG1177@1|root,COG1177@2|Bacteria,1V0VD@1239|Firmicutes,25E3C@186801|Clostridia,3WJIJ@541000|Ruminococcaceae	186801|Clostridia	P	ABC-type spermidine putrescine transport system, permease component II	potC	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
DEZH2_k127_8657675_2	1392491.JIAE01000001_gene333	6.797e-141	462.0	COG1176@1|root,COG1176@2|Bacteria,1TQ7Z@1239|Firmicutes,247Y8@186801|Clostridia,3WHJ9@541000|Ruminococcaceae	186801|Clostridia	P	ABC-type spermidine putrescine transport system, permease component I	potB	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
DEZH2_k127_8657675_1	1392491.JIAE01000001_gene332	2.298e-192	607.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3WGI6@541000|Ruminococcaceae	186801|Clostridia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
DEZH2_k127_8657675_5	1410638.JHXJ01000018_gene540	5.562e-65	226.0	COG1396@1|root,COG1396@2|Bacteria,1V1K5@1239|Firmicutes,24FTC@186801|Clostridia,3WMD8@541000|Ruminococcaceae	186801|Clostridia	K	Cupin domain	puuR	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_19,HTH_3
DEZH2_k127_8657675_4	1392491.JIAE01000001_gene337	4.25e-102	339.0	COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia,3WGZ7@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
DEZH2_k127_8657675_0	1410638.JHXJ01000018_gene534	8.927e-303	948.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,248A4@186801|Clostridia,3WHIF@541000|Ruminococcaceae	186801|Clostridia	M	penicillin-binding protein	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
DEZH2_k127_8657675_6	926561.KB900620_gene3066	3.827e-37	152.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,3WA7H@53433|Halanaerobiales	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
DEZH2_k127_867457_3	537013.CLOSTMETH_00715	3.644e-19	89.0	COG0159@1|root,COG0159@2|Bacteria,1TPXA@1239|Firmicutes,248M2@186801|Clostridia,3WGC4@541000|Ruminococcaceae	186801|Clostridia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
DEZH2_k127_867457_0	203119.Cthe_1412	9.575e-172	546.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,3WGIV@541000|Ruminococcaceae	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DEZH2_k127_867457_2	1232447.BAHW02000009_gene266	9.121e-68	240.0	COG0134@1|root,COG0134@2|Bacteria,1TR94@1239|Firmicutes,249ZY@186801|Clostridia,268Z9@186813|unclassified Clostridiales	186801|Clostridia	E	Indole-3-glycerol phosphate synthase	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
DEZH2_k127_867457_1	203119.Cthe_0873	9.085e-88	297.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,3WHFS@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
DEZH2_k127_8678296_2	349741.Amuc_1902	7.287e-53	188.0	COG0822@1|root,COG0822@2|Bacteria	2|Bacteria	C	iron-sulfur transferase activity	BT0174	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
DEZH2_k127_8678296_0	1122931.AUAE01000014_gene2019	1.269e-182	574.0	2C4R5@1|root,2Z7JK@2|Bacteria,4NHGV@976|Bacteroidetes,2FMRU@200643|Bacteroidia,22VUI@171551|Porphyromonadaceae	976|Bacteroidetes	S	GGGtGRT protein	-	-	-	-	-	-	-	-	-	-	-	-	GGGtGRT
DEZH2_k127_8678296_1	545694.TREPR_0726	1.354e-177	570.0	COG1132@1|root,COG1132@2|Bacteria,2J5W8@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K06147,ko:K11085,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DEZH2_k127_8697366_2	398512.JQKC01000001_gene2454	2.306e-23	105.0	COG1680@1|root,COG1680@2|Bacteria,1TRR5@1239|Firmicutes,249KP@186801|Clostridia,3WKA3@541000|Ruminococcaceae	186801|Clostridia	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase,Cu_amine_oxidN1,DUF3471
DEZH2_k127_8697366_1	941824.TCEL_01435	4.053e-29	119.0	COG4627@1|root,COG4627@2|Bacteria,1VACW@1239|Firmicutes,24NCH@186801|Clostridia,36NEC@31979|Clostridiaceae	186801|Clostridia	S	Stress responsive A B barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
DEZH2_k127_8697366_3	1449050.JNLE01000003_gene2047	4.8e-08	55.0	COG1600@1|root,COG1600@2|Bacteria,1UFJF@1239|Firmicutes,24GR0@186801|Clostridia,36JEH@31979|Clostridiaceae	186801|Clostridia	C	binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
DEZH2_k127_8697366_4	768706.Desor_2553	3.126e-06	53.0	COG2161@1|root,COG2161@2|Bacteria,1VA6W@1239|Firmicutes,24PDE@186801|Clostridia,262J7@186807|Peptococcaceae	186801|Clostridia	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
DEZH2_k127_8697366_0	1274374.CBLK010000079_gene4009	1.322e-57	205.0	COG0500@1|root,COG2267@1|root,COG2226@2|Bacteria,COG2267@2|Bacteria,1TR4J@1239|Firmicutes	1239|Firmicutes	Q	belongs to the nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_870538_4	1410638.JHXJ01000019_gene480	1.106e-11	66.0	COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,24MQV@186801|Clostridia,3WJU7@541000|Ruminococcaceae	186801|Clostridia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
DEZH2_k127_870538_2	1392491.JIAE01000001_gene2290	8.447e-46	169.0	COG0629@1|root,COG0629@2|Bacteria,1V3WT@1239|Firmicutes,24HF9@186801|Clostridia,3WJAP@541000|Ruminococcaceae	186801|Clostridia	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
DEZH2_k127_870538_3	1392491.JIAE01000001_gene2291	3.046e-30	121.0	COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,24QZQ@186801|Clostridia,3WKNW@541000|Ruminococcaceae	186801|Clostridia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
DEZH2_k127_870538_0	1392491.JIAE01000001_gene2292	9.513e-125	419.0	COG0009@1|root,COG0009@2|Bacteria,1TP1I@1239|Firmicutes,248HS@186801|Clostridia,3WGIY@541000|Ruminococcaceae	186801|Clostridia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
DEZH2_k127_870538_1	1195236.CTER_2026	9.37e-62	215.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,3WGA4@541000|Ruminococcaceae	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
DEZH2_k127_8715025_3	411470.RUMGNA_02951	6.5e-07	51.0	2BZDJ@1|root,2ZPU3@2|Bacteria,1W5XA@1239|Firmicutes,255BW@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8715025_0	994573.T472_0204565	7.507e-317	990.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,36DXW@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	macB3	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,FtsX,MacB_PCD
DEZH2_k127_8715025_2	871963.Desdi_1017	2.262e-10	67.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	mucS	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR,MarR_2
DEZH2_k127_8715025_1	588581.Cpap_3588	3.214e-119	387.0	COG0187@1|root,COG0187@2|Bacteria,1TQ6U@1239|Firmicutes,249NI@186801|Clostridia,3WH8Y@541000|Ruminococcaceae	186801|Clostridia	L	DNA topoisomerase	-	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
DEZH2_k127_8723863_0	699246.HMPREF0868_0868	4.009e-158	505.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,267PJ@186813|unclassified Clostridiales	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
DEZH2_k127_8723863_1	1392491.JIAE01000001_gene1763	1.488e-98	337.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,3WGZ1@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,Fer4_10,Fer4_7,Fer4_9,NQRA_SLBB,RnfC_N,SLBB
DEZH2_k127_8723863_2	525255.HMPREF0077_0681	1.485e-51	195.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,22GBF@1570339|Peptoniphilaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
DEZH2_k127_8723863_3	1392491.JIAE01000001_gene1761	8.153e-37	154.0	COG4939@1|root,COG4939@2|Bacteria,1V3CW@1239|Firmicutes,24I7I@186801|Clostridia,3WRB1@541000|Ruminococcaceae	186801|Clostridia	S	FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
DEZH2_k127_8874446_3	1408422.JHYF01000010_gene3271	1.878e-16	80.0	COG0579@1|root,COG0579@2|Bacteria,1TRDH@1239|Firmicutes,248IK@186801|Clostridia,36DNW@31979|Clostridiaceae	186801|Clostridia	C	FAD dependent oxidoreductase	glpA	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
DEZH2_k127_8874446_2	1105031.HMPREF1141_0858	1.502e-37	145.0	COG0579@1|root,COG0579@2|Bacteria,1TRDH@1239|Firmicutes,248IK@186801|Clostridia,36DNW@31979|Clostridiaceae	186801|Clostridia	C	FAD dependent oxidoreductase	glpA	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
DEZH2_k127_8874446_0	1392491.JIAE01000001_gene647	4.552e-262	819.0	COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,3WI2G@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
DEZH2_k127_8874446_1	1280664.AUIX01000001_gene682	2.343e-58	212.0	COG0507@1|root,COG0507@2|Bacteria,1VQVT@1239|Firmicutes,24YPM@186801|Clostridia,4BXJU@830|Butyrivibrio	186801|Clostridia	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8890050_2	1280688.AUJB01000005_gene166	1.301e-06	51.0	COG2333@1|root,COG2333@2|Bacteria,1UEY5@1239|Firmicutes,24E8K@186801|Clostridia,3NHIZ@46205|Pseudobutyrivibrio	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DEZH2_k127_8890050_0	1392491.JIAE01000001_gene2439	1.344e-94	327.0	COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,248WV@186801|Clostridia,3WH9R@541000|Ruminococcaceae	186801|Clostridia	M	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
DEZH2_k127_8890050_1	764299.STRIC_1482	3.123e-50	183.0	COG1216@1|root,COG1216@2|Bacteria,1TS11@1239|Firmicutes,4HDKY@91061|Bacilli	91061|Bacilli	S	glycosyl transferase family 2	ycbB	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
DEZH2_k127_8911115_1	1410638.JHXJ01000015_gene2450	3.635e-16	87.0	2CZNZ@1|root,32T6S@2|Bacteria,1UMAD@1239|Firmicutes,24IBZ@186801|Clostridia	186801|Clostridia	S	TPM domain	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
DEZH2_k127_8911115_0	1410638.JHXJ01000015_gene2449	4.147e-55	205.0	COG1996@1|root,COG1996@2|Bacteria,1UI9I@1239|Firmicutes,248XK@186801|Clostridia,3WHNV@541000|Ruminococcaceae	186801|Clostridia	K	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8911115_2	689781.AUJX01000033_gene303	0.0002532	48.0	COG1645@1|root,COG1645@2|Bacteria,1TRYG@1239|Firmicutes,25F3V@186801|Clostridia,2PRN0@265975|Oribacterium	186801|Clostridia	S	bacterial-type flagellum-dependent swarming motility	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8929995_2	509191.AEDB02000023_gene3631	2.394e-45	171.0	COG4976@1|root,COG4976@2|Bacteria,1UHZM@1239|Firmicutes,24A6U@186801|Clostridia,3WSIZ@541000|Ruminococcaceae	186801|Clostridia	S	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
DEZH2_k127_8929995_0	1392491.JIAE01000001_gene515	8.712e-102	342.0	COG1281@1|root,COG1281@2|Bacteria,1TRCH@1239|Firmicutes,24940@186801|Clostridia,3WHW9@541000|Ruminococcaceae	186801|Clostridia	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
DEZH2_k127_8929995_1	1392491.JIAE01000001_gene2498	2.126e-46	169.0	COG0051@1|root,COG0051@2|Bacteria,1V6C9@1239|Firmicutes,24JDC@186801|Clostridia,3WPSH@541000|Ruminococcaceae	186801|Clostridia	J	Ribosomal protein S10p/S20e	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
DEZH2_k127_8929995_3	1410638.JHXJ01000008_gene376	9.61e-14	71.0	COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,3WHH0@541000|Ruminococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
DEZH2_k127_89540_2	1410638.JHXJ01000002_gene1432	1.835e-51	189.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,3WHRZ@541000|Ruminococcaceae	186801|Clostridia	E	histidinol phosphate phosphatase HisJ family	hisK	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
DEZH2_k127_89540_1	203119.Cthe_0721	1.011e-58	206.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,3WITG@541000|Ruminococcaceae	186801|Clostridia	C	Fe-S iron-sulfur cluster assembly protein, NifU family	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
DEZH2_k127_89540_0	1121335.Clst_0879	5.948e-152	490.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,3WG87@541000|Ruminococcaceae	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
DEZH2_k127_89540_3	398512.JQKC01000018_gene2936	9.449e-48	173.0	COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,247X2@186801|Clostridia,3WGT0@541000|Ruminococcaceae	186801|Clostridia	L	ATPase, AAA family	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
DEZH2_k127_8972427_2	1392491.JIAE01000001_gene658	7.271e-83	278.0	COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,248EB@186801|Clostridia,3WGEU@541000|Ruminococcaceae	186801|Clostridia	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
DEZH2_k127_8972427_0	1392491.JIAE01000001_gene657	1.317e-224	702.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,3WGNU@541000|Ruminococcaceae	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
DEZH2_k127_8972427_1	1121335.Clst_0739	2.781e-115	387.0	COG1625@1|root,COG1625@2|Bacteria,1TSFU@1239|Firmicutes,247JK@186801|Clostridia,3WGI9@541000|Ruminococcaceae	186801|Clostridia	C	FeS-containing Cyanobacterial-specific oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF512,PDZ,PDZ_2,Radical_SAM
DEZH2_k127_8972427_3	1410638.JHXJ01000005_gene2133	1.421e-27	112.0	COG0333@1|root,COG0333@2|Bacteria,1VEFI@1239|Firmicutes,24QM0@186801|Clostridia,3WKRF@541000|Ruminococcaceae	186801|Clostridia	J	Ribosomal L32p protein family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
DEZH2_k127_8994392_1	886293.Sinac_4302	3.377e-83	287.0	COG3266@1|root,COG4655@1|root,COG4932@1|root,COG3266@2|Bacteria,COG4655@2|Bacteria,COG4932@2|Bacteria,2IZVN@203682|Planctomycetes	203682|Planctomycetes	M	Protein of unknown function (DUF3494)	-	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	DUF3494
DEZH2_k127_8994392_0	886293.Sinac_4302	1.728e-95	327.0	COG3266@1|root,COG4655@1|root,COG4932@1|root,COG3266@2|Bacteria,COG4655@2|Bacteria,COG4932@2|Bacteria,2IZVN@203682|Planctomycetes	203682|Planctomycetes	M	Protein of unknown function (DUF3494)	-	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	DUF3494
DEZH2_k127_8994392_2	398512.JQKC01000069_gene4287	1.615e-43	169.0	2DPJ8@1|root,332BG@2|Bacteria,1UVEZ@1239|Firmicutes,25KH3@186801|Clostridia,3WMJS@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_8994392_3	592026.GCWU0000282_000075	6.475e-07	62.0	2B39J@1|root,31VXQ@2|Bacteria,1V76E@1239|Firmicutes,24K15@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9001808_3	1410638.JHXJ01000003_gene1500	5.926e-40	154.0	COG0580@1|root,COG3859@1|root,COG0580@2|Bacteria,COG3859@2|Bacteria,1TP4T@1239|Firmicutes,248U5@186801|Clostridia,3WGG8@541000|Ruminococcaceae	186801|Clostridia	G	Major intrinsic protein	-	-	-	ko:K02440,ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.2	-	-	MIP
DEZH2_k127_9001808_2	1392491.JIAE01000001_gene2221	1.251e-80	279.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,249J1@186801|Clostridia,3WK39@541000|Ruminococcaceae	186801|Clostridia	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	FSH1,Hydrolase_4,Peptidase_S9
DEZH2_k127_9001808_1	1392491.JIAE01000001_gene2222	1.538e-82	289.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,3WGZP@541000|Ruminococcaceae	186801|Clostridia	E	Xaa-Pro aminopeptidase	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Creatinase_N,Peptidase_M24
DEZH2_k127_9001808_0	1392491.JIAE01000001_gene2223	1.629e-100	331.0	COG1045@1|root,COG1045@2|Bacteria,1VCIW@1239|Firmicutes,24NIX@186801|Clostridia	186801|Clostridia	E	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
DEZH2_k127_9035699_4	720554.Clocl_1737	1.011e-138	446.0	COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,247X2@186801|Clostridia,3WGT0@541000|Ruminococcaceae	186801|Clostridia	L	ATPase, AAA family	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
DEZH2_k127_9035699_1	1410638.JHXJ01000002_gene1364	1.21e-210	660.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,3WGJK@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
DEZH2_k127_9035699_6	1392491.JIAE01000001_gene1265	1.304e-105	352.0	COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia,3WIME@541000|Ruminococcaceae	186801|Clostridia	O	PFAM AIR synthase related protein	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
DEZH2_k127_9035699_3	1392491.JIAE01000001_gene1264	1.432e-144	472.0	COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia,3WGMK@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
DEZH2_k127_9035699_5	1392491.JIAE01000001_gene1263	1.919e-112	374.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,3WGVY@541000|Ruminococcaceae	186801|Clostridia	E	aminotransferase class V	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
DEZH2_k127_9035699_0	1392491.JIAE01000001_gene1439	4.437e-213	671.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia,3WG9P@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
DEZH2_k127_9035699_2	1410638.JHXJ01000010_gene107	8.423e-151	488.0	COG1167@1|root,COG1167@2|Bacteria,1TPMY@1239|Firmicutes,24986@186801|Clostridia,3WGVJ@541000|Ruminococcaceae	186801|Clostridia	EK	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_MocR
DEZH2_k127_9035699_7	1392491.JIAE01000001_gene1441	6.789e-07	51.0	COG0792@1|root,COG0792@2|Bacteria	2|Bacteria	L	nuclease activity	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
DEZH2_k127_903674_1	1280666.ATVS01000007_gene1391	3.58e-12	75.0	COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia,4BX5S@830|Butyrivibrio	186801|Clostridia	L	PD-(D/E)XK nuclease superfamily	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
DEZH2_k127_903674_0	699246.HMPREF0868_1379	2.773e-28	127.0	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,268GR@186813|unclassified Clostridiales	186801|Clostridia	L	ATP-dependent helicase nuclease subunit A	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
DEZH2_k127_9055796_2	180332.JTGN01000002_gene5735	1.094e-39	154.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia	186801|Clostridia	C	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
DEZH2_k127_9055796_1	1216932.CM240_2710	1.146e-54	196.0	COG0454@1|root,COG0454@2|Bacteria,1V1JN@1239|Firmicutes,24C53@186801|Clostridia,36KEM@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
DEZH2_k127_9055796_0	693746.OBV_02240	2.74e-94	315.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
DEZH2_k127_9099006_9	1121445.ATUZ01000013_gene1089	1.788e-10	62.0	COG0384@1|root,COG0384@2|Bacteria	2|Bacteria	S	isomerase activity	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
DEZH2_k127_9099006_5	1111134.HMPREF1253_0979	5.807e-44	168.0	COG3428@1|root,COG3428@2|Bacteria,1VD6M@1239|Firmicutes	1239|Firmicutes	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
DEZH2_k127_9099006_2	33035.JPJF01000051_gene822	3.495e-61	222.0	COG1476@1|root,COG1476@2|Bacteria,1V7I5@1239|Firmicutes,24KRY@186801|Clostridia,3Y0HW@572511|Blautia	186801|Clostridia	K	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
DEZH2_k127_9099006_8	1231241.Mc24_03038	1.086e-23	106.0	COG2153@1|root,COG2153@2|Bacteria,2GE9G@200918|Thermotogae	200918|Thermotogae	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
DEZH2_k127_9099006_7	1195236.CTER_1891	5.895e-24	104.0	COG3860@1|root,COG3860@2|Bacteria,1VICJ@1239|Firmicutes,24RGR@186801|Clostridia	186801|Clostridia	S	Uncharacterized protein conserved in bacteria (DUF2087)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087
DEZH2_k127_9099006_3	698758.AXY_13820	5.575e-48	177.0	COG1246@1|root,COG1246@2|Bacteria,1V4QW@1239|Firmicutes,4HIWY@91061|Bacilli	91061|Bacilli	E	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
DEZH2_k127_9099006_0	904296.HMPREF9124_0384	1.98e-116	381.0	COG2253@1|root,COG2253@2|Bacteria,1UQS7@1239|Firmicutes,258IB@186801|Clostridia,2PTT3@265975|Oribacterium	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9099006_1	1121105.ATXL01000010_gene892	2.116e-64	227.0	COG5340@1|root,COG5340@2|Bacteria,1V49B@1239|Firmicutes	1239|Firmicutes	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9099006_6	1291050.JAGE01000001_gene697	2.179e-40	159.0	COG5522@1|root,COG5522@2|Bacteria,1UPRM@1239|Firmicutes	1239|Firmicutes	S	Integral membrane protein (intg_mem_TP0381)	-	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
DEZH2_k127_9099006_4	592026.GCWU0000282_000831	4.851e-47	182.0	COG1266@1|root,COG1266@2|Bacteria,1V822@1239|Firmicutes,24CBM@186801|Clostridia	186801|Clostridia	CP	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Abi
DEZH2_k127_9099006_10	877424.ATWC01000015_gene668	0.0002798	45.0	COG1266@1|root,COG1266@2|Bacteria,1VKW2@1239|Firmicutes,24QJG@186801|Clostridia,27TH6@186928|unclassified Lachnospiraceae	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
DEZH2_k127_9101926_0	720554.Clocl_2210	2.669e-127	420.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
DEZH2_k127_9101926_1	203119.Cthe_1847	3.727e-96	319.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,248BR@186801|Clostridia,3WN5V@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DEZH2_k127_9101926_3	580340.Tlie_0481	1.77e-38	151.0	COG1280@1|root,COG1280@2|Bacteria	2|Bacteria	E	homoserine transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	LysE
DEZH2_k127_9101926_2	906968.Trebr_1040	6.189e-65	235.0	COG2320@1|root,COG2320@2|Bacteria,2J98C@203691|Spirochaetes	203691|Spirochaetes	S	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
DEZH2_k127_9101926_4	1507.HMPREF0262_03199	4.958e-33	141.0	COG0454@1|root,COG0456@2|Bacteria,1VJPU@1239|Firmicutes,25E53@186801|Clostridia,36IGR@31979|Clostridiaceae	186801|Clostridia	K	acetyltransferase, GNAT family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DEZH2_k127_9129655_0	428125.CLOLEP_01495	8.792e-135	436.0	COG1586@1|root,COG1586@2|Bacteria,1TQ7S@1239|Firmicutes,2480M@186801|Clostridia,3WHEX@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speD	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
DEZH2_k127_9129655_1	1487923.DP73_15345	5.515e-119	387.0	COG1982@1|root,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia,2610R@186807|Peptococcaceae	186801|Clostridia	E	Orn Lys Arg decarboxylase major	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
DEZH2_k127_9146250_3	1507.HMPREF0262_03596	3.704e-95	316.0	COG2013@1|root,COG2013@2|Bacteria,1TPN2@1239|Firmicutes,2499B@186801|Clostridia,36E74@31979|Clostridiaceae	186801|Clostridia	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
DEZH2_k127_9146250_0	431943.CKL_3062	2.601e-239	745.0	COG1350@1|root,COG1350@2|Bacteria,1UI01@1239|Firmicutes,25E8Q@186801|Clostridia,36UNS@31979|Clostridiaceae	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DEZH2_k127_9146250_4	1118054.CAGW01000108_gene3643	2.882e-79	278.0	COG1194@1|root,COG1194@2|Bacteria,1TPUT@1239|Firmicutes,4H9UM@91061|Bacilli,26SYT@186822|Paenibacillaceae	91061|Bacilli	L	Adenine glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
DEZH2_k127_9146250_2	1392491.JIAE01000001_gene2043	3.629e-108	360.0	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia,3WGGT@541000|Ruminococcaceae	186801|Clostridia	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
DEZH2_k127_9146250_1	1410638.JHXJ01000006_gene2529	1.093e-152	490.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,3WH82@541000|Ruminococcaceae	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
DEZH2_k127_9146250_6	1410638.JHXJ01000006_gene2528	0.0005016	42.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,3WGES@541000|Ruminococcaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
DEZH2_k127_9146250_5	1392491.JIAE01000001_gene961	8.351e-20	90.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,3WGES@541000|Ruminococcaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
DEZH2_k127_9177169_1	1216932.CM240_2883	7.801e-105	345.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,36DUF@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DEZH2_k127_9177169_4	456442.Mboo_1256	9.401e-40	154.0	COG0703@1|root,arCOG01047@2157|Archaea,2Y4C3@28890|Euryarchaeota,2NB05@224756|Methanomicrobia	224756|Methanomicrobia	E	Shikimate kinase	-	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
DEZH2_k127_9177169_3	1131462.DCF50_p2392	9.213e-41	154.0	COG3304@1|root,COG3304@2|Bacteria,1VADH@1239|Firmicutes,24NFV@186801|Clostridia,2657F@186807|Peptococcaceae	186801|Clostridia	S	membrane	yccF	-	-	-	-	-	-	-	-	-	-	-	YccF
DEZH2_k127_9177169_2	903814.ELI_1350	2.265e-75	260.0	COG1573@1|root,COG1573@2|Bacteria,1UY78@1239|Firmicutes,24FDP@186801|Clostridia,25ZVV@186806|Eubacteriaceae	186801|Clostridia	L	Domain of unknown function (DUF4130	-	-	-	-	-	-	-	-	-	-	-	-	DUF4130
DEZH2_k127_9177169_0	1274374.CBLK010000005_gene4569	1.134e-187	598.0	COG4277@1|root,COG4277@2|Bacteria,1TRT2@1239|Firmicutes,4HUPG@91061|Bacilli,26RY8@186822|Paenibacillaceae	91061|Bacilli	S	Helix-hairpin-helix DNA-binding motif class 1	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Radical_SAM
DEZH2_k127_9189387_1	1123075.AUDP01000019_gene1643	1.387e-61	213.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,24AER@186801|Clostridia,3WH5B@541000|Ruminococcaceae	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
DEZH2_k127_9189387_5	1410630.JNKP01000005_gene844	2.269e-31	124.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,24AER@186801|Clostridia,27J3Z@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
DEZH2_k127_9189387_0	1414720.CBYM010000003_gene423	4.092e-110	364.0	COG4667@1|root,COG4667@2|Bacteria,1TQ9W@1239|Firmicutes,2485C@186801|Clostridia,36FP3@31979|Clostridiaceae	186801|Clostridia	S	Phospholipase, patatin family	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
DEZH2_k127_9189387_3	1219626.HMPREF1639_01380	8.025e-49	184.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia,25R8Q@186804|Peptostreptococcaceae	186801|Clostridia	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
DEZH2_k127_9189387_2	1131462.DCF50_p1074	3.53e-49	190.0	COG2199@1|root,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,24A8B@186801|Clostridia,265M5@186807|Peptococcaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,GGDEF,PAS,PAS_8,PAS_9,Response_reg
DEZH2_k127_9189387_4	208596.CAR_c19050	1.216e-44	166.0	COG0824@1|root,COG0824@2|Bacteria,1VAGM@1239|Firmicutes,4HIVC@91061|Bacilli,27GE5@186828|Carnobacteriaceae	91061|Bacilli	S	Thioesterase-like superfamily	yneP	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
DEZH2_k127_9189387_6	1235799.C818_01961	7.137e-12	76.0	COG4676@1|root,COG4676@2|Bacteria,1VF8Z@1239|Firmicutes,24S72@186801|Clostridia,27PHZ@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TPR_11
DEZH2_k127_9195449_0	699246.HMPREF0868_0093	1.879e-125	416.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,267W5@186813|unclassified Clostridiales	186801|Clostridia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
DEZH2_k127_9195449_2	1392491.JIAE01000001_gene94	3.597e-41	162.0	COG3764@1|root,COG3764@2|Bacteria,1UN9R@1239|Firmicutes,24CEQ@186801|Clostridia,3WMR8@541000|Ruminococcaceae	186801|Clostridia	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
DEZH2_k127_9195449_1	1392491.JIAE01000001_gene93	2.746e-70	247.0	COG0771@1|root,COG0771@2|Bacteria,1UHPI@1239|Firmicutes,25E9J@186801|Clostridia,3WSID@541000|Ruminococcaceae	186801|Clostridia	M	Mur ligase middle domain	murE2	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	DUF1727,Mur_ligase_M
DEZH2_k127_9215884_1	1235835.C814_00685	2.444e-51	185.0	COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,3WGGC@541000|Ruminococcaceae	186801|Clostridia	C	domain protein	nfnA	-	1.18.1.2,1.19.1.1	ko:K00528,ko:K16951	ko00920,ko01120,map00920,map01120	-	R00858,R10146,R10159	RC00065	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
DEZH2_k127_9215884_0	469618.FVAG_00082	4.231e-59	215.0	COG0561@1|root,COG0561@2|Bacteria,378P3@32066|Fusobacteria	32066|Fusobacteria	S	PFAM Haloacid dehalogenase domain protein hydrolase type 3	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
DEZH2_k127_9215884_2	1321778.HMPREF1982_01713	1.589e-35	147.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia	186801|Clostridia	T	Diguanylate cyclase	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	EAL,GGDEF,SBP_bac_3
DEZH2_k127_9227674_2	1449335.JQLG01000004_gene1683	1.884e-70	239.0	arCOG06481@1|root,2ZB4E@2|Bacteria,1V0ND@1239|Firmicutes,4HFG5@91061|Bacilli,27FK3@186828|Carnobacteriaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9227674_0	545694.TREPR_3458	1.117e-228	719.0	COG0591@1|root,COG0591@2|Bacteria,2J5R8@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21.2	-	-	SSF
DEZH2_k127_9227674_3	1469948.JPNB01000002_gene2749	4.072e-58	208.0	COG2227@1|root,COG2227@2|Bacteria,1V1MT@1239|Firmicutes,24FTN@186801|Clostridia,36UPY@31979|Clostridiaceae	186801|Clostridia	H	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25,NUDIX
DEZH2_k127_9227674_1	913865.DOT_5901	2.389e-90	302.0	COG3369@1|root,COG3369@2|Bacteria,1TV60@1239|Firmicutes,24D1A@186801|Clostridia,264MH@186807|Peptococcaceae	186801|Clostridia	S	CDGSH-type zinc finger. Function unknown.	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_19,zf-CDGSH
DEZH2_k127_9227674_4	717605.Theco_1691	2.41e-09	59.0	COG0791@1|root,COG0791@2|Bacteria,1VCFE@1239|Firmicutes,4HMQC@91061|Bacilli,26VN8@186822|Paenibacillaceae	91061|Bacilli	M	hydrolase	spr5	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
DEZH2_k127_9282904_6	411490.ANACAC_03329	1.06e-33	136.0	COG3279@1|root,COG3279@2|Bacteria,1VBF7@1239|Firmicutes,24G1R@186801|Clostridia	186801|Clostridia	K	Response regulator of the LytR AlgR family	-	-	-	-	-	-	-	-	-	-	-	-	LytTR
DEZH2_k127_9282904_3	1105031.HMPREF1141_3382	3.908e-131	426.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1TQ3E@1239|Firmicutes,247UT@186801|Clostridia,36VB2@31979|Clostridiaceae	186801|Clostridia	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
DEZH2_k127_9282904_7	596315.HMPREF0634_0903	3.097e-27	119.0	COG1525@1|root,COG1525@2|Bacteria,1V8AM@1239|Firmicutes,25BE0@186801|Clostridia,25RW9@186804|Peptostreptococcaceae	186801|Clostridia	L	Staphylococcal nuclease homologues	-	-	-	-	-	-	-	-	-	-	-	-	SNase
DEZH2_k127_9282904_4	641107.CDLVIII_0019	2.291e-123	416.0	COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24Y6H@186801|Clostridia,36QQN@31979|Clostridiaceae	186801|Clostridia	KT	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HAMP,HD,HD_5,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3,dCache_1
DEZH2_k127_9282904_2	1262449.CP6013_1703	1.009e-133	446.0	COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5
DEZH2_k127_9282904_0	537013.CLOSTMETH_03296	2.752e-272	850.0	COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,3WGIX@541000|Ruminococcaceae	186801|Clostridia	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoA,FeoB_C,FeoB_N,Gate
DEZH2_k127_9282904_9	1120746.CCNL01000010_gene1223	2.71e-10	60.0	COG0370@1|root,COG0370@2|Bacteria,2NNZ4@2323|unclassified Bacteria	2|Bacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
DEZH2_k127_9282904_8	1449050.JNLE01000003_gene2732	3.741e-25	108.0	COG1918@1|root,COG1918@2|Bacteria,1VEHC@1239|Firmicutes,24QKE@186801|Clostridia,36MTC@31979|Clostridiaceae	186801|Clostridia	P	ferrous iron transport protein	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
DEZH2_k127_9282904_1	760011.Spico_0768	2.165e-236	743.0	COG0366@1|root,COG0366@2|Bacteria,2J6AH@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	treA	-	3.2.1.10,3.2.1.93	ko:K01182,ko:K01226	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00837,R01718,R01791,R06113,R06199	RC00028,RC00049,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459,Malt_amylase_C
DEZH2_k127_9282904_5	760011.Spico_0769	2.819e-51	187.0	COG3345@1|root,COG3345@2|Bacteria,2J68S@203691|Spirochaetes	203691|Spirochaetes	G	alpha-galactosidase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
DEZH2_k127_9306138_1	1136138.JH604622_gene2296	4.674e-59	214.0	COG1082@1|root,COG1082@2|Bacteria,1NS0A@1224|Proteobacteria	1224|Proteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DEZH2_k127_9306138_0	1392491.JIAE01000001_gene388	4.4e-180	571.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,3WHHZ@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2,LuxC
DEZH2_k127_9334179_1	1392491.JIAE01000001_gene100	3.189e-112	367.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,3WGTZ@541000|Ruminococcaceae	186801|Clostridia	D	CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
DEZH2_k127_9334179_2	1392491.JIAE01000001_gene101	1.289e-111	368.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,3WHV1@541000|Ruminococcaceae	186801|Clostridia	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
DEZH2_k127_9334179_0	497965.Cyan7822_4617	2.319e-127	432.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	EAL,Glyco_trans_2_3,Glycos_transf_2
DEZH2_k127_9351422_0	1410638.JHXJ01000021_gene2399	2.163e-277	861.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,3WGDM@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
DEZH2_k127_9351422_3	1392491.JIAE01000001_gene1801	6.849e-86	287.0	COG1014@1|root,COG1014@2|Bacteria,1UYYG@1239|Firmicutes,24I53@186801|Clostridia,3WJ35@541000|Ruminococcaceae	186801|Clostridia	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases gamma subunit	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
DEZH2_k127_9351422_2	1392491.JIAE01000001_gene1802	1.932e-132	424.0	COG1013@1|root,COG1013@2|Bacteria,1UZ67@1239|Firmicutes,247Q7@186801|Clostridia,3WGN9@541000|Ruminococcaceae	186801|Clostridia	C	thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
DEZH2_k127_9351422_1	1392491.JIAE01000001_gene1803	2.206e-182	575.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,3WH2U@541000|Ruminococcaceae	186801|Clostridia	C	ferredoxin oxidoreductase	vorB	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
DEZH2_k127_9351422_4	1392491.JIAE01000001_gene1804	1.016e-31	124.0	COG1146@1|root,COG1146@2|Bacteria,1VETY@1239|Firmicutes,25E51@186801|Clostridia,3WKXM@541000|Ruminococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7
DEZH2_k127_9351422_5	37659.JNLN01000001_gene2089	7.562e-23	106.0	COG1268@1|root,COG1268@2|Bacteria,1VAY6@1239|Firmicutes,24HU5@186801|Clostridia,36DWS@31979|Clostridiaceae	186801|Clostridia	S	hmm pf02632	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
DEZH2_k127_9351422_6	1203606.HMPREF1526_03031	1.098e-16	81.0	COG4260@1|root,COG4260@2|Bacteria,1TRYU@1239|Firmicutes,24901@186801|Clostridia,36GFC@31979|Clostridiaceae	186801|Clostridia	L	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,SHOCT
DEZH2_k127_9353635_1	1392491.JIAE01000001_gene753	1.023e-245	766.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,3WGRU@541000|Ruminococcaceae	186801|Clostridia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
DEZH2_k127_9353635_4	1410638.JHXJ01000006_gene2535	9.512e-53	198.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24MVR@186801|Clostridia,3WRVQ@541000|Ruminococcaceae	186801|Clostridia	U	Signal peptidase, peptidase S26	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
DEZH2_k127_9353635_0	1392491.JIAE01000001_gene711	8.853e-282	877.0	COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,247Z3@186801|Clostridia,3WGX1@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
DEZH2_k127_9353635_2	1410638.JHXJ01000006_gene2533	3.046e-179	571.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,3WHGY@541000|Ruminococcaceae	186801|Clostridia	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
DEZH2_k127_9353635_3	1392491.JIAE01000001_gene709	4.004e-60	217.0	COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia,3WIFN@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
DEZH2_k127_9353635_5	1410622.JNKY01000010_gene1100	2.349e-23	100.0	COG2013@1|root,COG2013@2|Bacteria,1TPN2@1239|Firmicutes,2499B@186801|Clostridia,27J0S@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
DEZH2_k127_9353794_6	1121468.AUBR01000006_gene370	6.693e-18	93.0	COG3879@1|root,COG3879@2|Bacteria,1V66C@1239|Firmicutes,2492Y@186801|Clostridia,42JD3@68295|Thermoanaerobacterales	186801|Clostridia	S	Bacterial protein of unknown function (DUF881)	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
DEZH2_k127_9353794_4	1235797.C816_02056	1.271e-24	121.0	COG0419@1|root,COG0419@2|Bacteria,1UI2P@1239|Firmicutes,25EBC@186801|Clostridia,2N67G@216572|Oscillospiraceae	186801|Clostridia	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23,AAA_27
DEZH2_k127_9353794_1	1514668.JOOA01000001_gene396	1.437e-70	254.0	COG0420@1|root,COG0420@2|Bacteria,1TWMI@1239|Firmicutes,24BN3@186801|Clostridia,3WHWS@541000|Ruminococcaceae	186801|Clostridia	L	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
DEZH2_k127_9353794_0	545243.BAEV01000002_gene3278	2.514e-105	361.0	COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,247UR@186801|Clostridia,36EA0@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
DEZH2_k127_9353794_2	1415774.U728_630	1.31e-64	225.0	292S5@1|root,2ZQ9V@2|Bacteria,1V53B@1239|Firmicutes,24JDT@186801|Clostridia	186801|Clostridia	S	Putative zincin peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3267
DEZH2_k127_9353794_3	1235800.C819_03785	9.822e-49	181.0	COG0457@1|root,COG0457@2|Bacteria,1V5AR@1239|Firmicutes,24VKU@186801|Clostridia,27RJD@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9376871_1	428125.CLOLEP_03099	1.223e-75	272.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,3WI09@541000|Ruminococcaceae	186801|Clostridia	L	exonuclease	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
DEZH2_k127_9376871_0	699246.HMPREF0868_1337	7.344e-113	373.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,267JM@186813|unclassified Clostridiales	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
DEZH2_k127_9399733_4	1410638.JHXJ01000005_gene2129	3.925e-15	78.0	COG0826@1|root,COG0826@2|Bacteria,1TPRE@1239|Firmicutes,248I3@186801|Clostridia,3WGFB@541000|Ruminococcaceae	186801|Clostridia	O	Peptidase U32	yhbU_1	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
DEZH2_k127_9399733_0	1410638.JHXJ01000004_gene1967	3.617e-83	292.0	COG0628@1|root,COG0628@2|Bacteria,1TS4S@1239|Firmicutes,248E5@186801|Clostridia,3WJEJ@541000|Ruminococcaceae	186801|Clostridia	S	sporulation integral membrane protein YtvI	ytvI	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
DEZH2_k127_9399733_1	1392491.JIAE01000001_gene663	2.257e-58	213.0	COG1989@1|root,COG1989@2|Bacteria,1VMQF@1239|Firmicutes,24VEC@186801|Clostridia	186801|Clostridia	NOU	Type IV leader peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_A24
DEZH2_k127_9399733_2	1410638.JHXJ01000004_gene1964	3.385e-56	199.0	COG0058@1|root,COG0058@2|Bacteria,1TQAJ@1239|Firmicutes,248E1@186801|Clostridia,3WHEI@541000|Ruminococcaceae	186801|Clostridia	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
DEZH2_k127_9425588_2	585394.RHOM_14235	2.268e-59	208.0	COG1619@1|root,COG1619@2|Bacteria,1TRBB@1239|Firmicutes,24ABA@186801|Clostridia	186801|Clostridia	V	LD-carboxypeptidase	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
DEZH2_k127_9425588_1	871963.Desdi_0355	1.312e-153	490.0	COG2199@1|root,COG2199@2|Bacteria,1VTBQ@1239|Firmicutes,25EKJ@186801|Clostridia	186801|Clostridia	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3,PAS_4,dCache_1
DEZH2_k127_9425588_0	767817.Desgi_3530	0.0	1199.0	COG3437@1|root,COG5000@1|root,COG3437@2|Bacteria,COG5000@2|Bacteria,1TQ0S@1239|Firmicutes,24Y6H@186801|Clostridia,267AY@186807|Peptococcaceae	186801|Clostridia	T	diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HAMP,HD,HD_5,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3,dCache_1
DEZH2_k127_9425588_4	767817.Desgi_3530	1.217e-24	109.0	COG3437@1|root,COG5000@1|root,COG3437@2|Bacteria,COG5000@2|Bacteria,1TQ0S@1239|Firmicutes,24Y6H@186801|Clostridia,267AY@186807|Peptococcaceae	186801|Clostridia	T	diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HAMP,HD,HD_5,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3,dCache_1
DEZH2_k127_9425588_3	767817.Desgi_3532	3.287e-59	209.0	COG2199@1|root,COG2200@1|root,COG2202@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG2202@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia,267EP@186807|Peptococcaceae	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_9,Peripla_BP_3
DEZH2_k127_943381_1	1120998.AUFC01000005_gene608	1.462e-59	209.0	COG0288@1|root,COG0288@2|Bacteria,1V1EC@1239|Firmicutes,2495A@186801|Clostridia	186801|Clostridia	P	Reversible hydration of carbon dioxide	cah	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
DEZH2_k127_943381_0	1259795.ARJK01000004_gene1357	4.55e-179	575.0	COG1233@1|root,COG1233@2|Bacteria,1UU71@1239|Firmicutes	1239|Firmicutes	Q	Phytoene dehydrogenase	-	-	5.2.1.13	ko:K09835	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R07512	RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
DEZH2_k127_943381_2	351627.Csac_2426	1.698e-31	128.0	COG1215@1|root,COG1215@2|Bacteria,1TRAD@1239|Firmicutes,24FX5@186801|Clostridia,42IJ2@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DEZH2_k127_9489551_0	1121335.Clst_0011	2.459e-183	582.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,3WHDD@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
DEZH2_k127_9489551_3	180332.JTGN01000007_gene3723	2.563e-70	261.0	COG1368@1|root,COG1368@2|Bacteria,1TRMA@1239|Firmicutes,2480C@186801|Clostridia	186801|Clostridia	M	PFAM sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
DEZH2_k127_9489551_1	180332.JTGN01000007_gene3722	1.469e-78	286.0	COG1368@1|root,COG1368@2|Bacteria,1TRMA@1239|Firmicutes,2480C@186801|Clostridia	186801|Clostridia	M	PFAM sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
DEZH2_k127_9489551_2	1121335.Clst_2325	3.619e-73	255.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,3WGZ1@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,MTHFR_C,RnfC_N,SLBB
DEZH2_k127_9494989_3	1410638.JHXJ01000007_gene1061	1.244e-27	118.0	COG0355@1|root,COG0355@2|Bacteria	2|Bacteria	C	proton-transporting ATP synthase activity, rotational mechanism	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
DEZH2_k127_9494989_5	397288.C806_00475	1.468e-07	63.0	COG1716@1|root,COG1716@2|Bacteria,1V550@1239|Firmicutes,24BVK@186801|Clostridia,27P0N@186928|unclassified Lachnospiraceae	186801|Clostridia	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
DEZH2_k127_9494989_1	1410638.JHXJ01000007_gene1064	8.134e-108	369.0	COG4965@1|root,COG4965@2|Bacteria,1W08K@1239|Firmicutes,254C1@186801|Clostridia	186801|Clostridia	U	Type ii secretion system	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
DEZH2_k127_9494989_0	1392491.JIAE01000001_gene1571	3.633e-151	488.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,3WGJJ@541000|Ruminococcaceae	186801|Clostridia	U	Type II IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
DEZH2_k127_9494989_2	999411.HMPREF1092_02164	8.607e-93	312.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,36DDF@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
DEZH2_k127_9507152_2	1280692.AUJL01000005_gene1720	1.45e-14	75.0	COG1380@1|root,COG1380@2|Bacteria,1VEN4@1239|Firmicutes,24MMB@186801|Clostridia,36KP1@31979|Clostridiaceae	186801|Clostridia	S	LrgA family	lrgA	-	-	ko:K06518	-	-	-	-	ko00000,ko02000	1.E.14.2	-	-	LrgA
DEZH2_k127_9507152_1	1232449.BAHV02000002_gene250	1.331e-70	245.0	COG1346@1|root,COG1346@2|Bacteria,1TRGN@1239|Firmicutes,24AGM@186801|Clostridia,267ZZ@186813|unclassified Clostridiales	186801|Clostridia	M	LrgB-like family	lrgB	-	-	-	-	-	-	-	-	-	-	-	LrgB
DEZH2_k127_9507152_0	1122917.KB899671_gene4409	2.218e-140	457.0	COG3507@1|root,COG3507@2|Bacteria,1TSEQ@1239|Firmicutes,4HCI4@91061|Bacilli,26RDE@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
DEZH2_k127_9552992_1	1121335.Clst_0015	1.129e-112	369.0	COG1180@1|root,COG1180@2|Bacteria,1TP46@1239|Firmicutes,248K9@186801|Clostridia,3WI5Z@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
DEZH2_k127_9552992_5	1540257.JQMW01000014_gene245	2.706e-17	86.0	2ENWS@1|root,33GHQ@2|Bacteria,1VQNU@1239|Firmicutes,24TC6@186801|Clostridia,36T5H@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9552992_3	697281.Mahau_2869	8.468e-67	233.0	COG0569@1|root,COG0569@2|Bacteria,1V2ZF@1239|Firmicutes,24GNX@186801|Clostridia,42H6T@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM TrkA-N domain protein	trkA2	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_N
DEZH2_k127_9552992_2	697281.Mahau_2868	9.826e-80	271.0	COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia,42H8N@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM TrkA-N domain protein	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
DEZH2_k127_9552992_0	697281.Mahau_2866	3.071e-203	646.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,42GHF@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM cation transporter	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
DEZH2_k127_9552992_4	697281.Mahau_2865	3.133e-28	120.0	2EDRU@1|root,337MD@2|Bacteria,1VIEE@1239|Firmicutes,24P45@186801|Clostridia,42IRG@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_961214_3	1408321.JNJD01000006_gene1249	2.85e-84	282.0	COG1028@1|root,COG1028@2|Bacteria,1TRBI@1239|Firmicutes,24XI8@186801|Clostridia,27IDR@186928|unclassified Lachnospiraceae	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
DEZH2_k127_961214_10	509191.AEDB02000075_gene2817	4.683e-42	166.0	COG1670@1|root,COG1670@2|Bacteria,1UZR2@1239|Firmicutes	1239|Firmicutes	J	GNAT acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	GNAT_acetyltran
DEZH2_k127_961214_15	431943.CKL_0333	2.432e-32	131.0	COG0239@1|root,COG0239@2|Bacteria,1VEH7@1239|Firmicutes,24QSV@186801|Clostridia,36KYS@31979|Clostridiaceae	186801|Clostridia	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
DEZH2_k127_961214_11	431943.CKL_0334	2.36e-40	152.0	COG0239@1|root,COG0239@2|Bacteria,1VEH7@1239|Firmicutes,24QSV@186801|Clostridia,36M3K@31979|Clostridiaceae	186801|Clostridia	U	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
DEZH2_k127_961214_0	671143.DAMO_1697	4.794e-188	604.0	COG0004@1|root,COG0004@2|Bacteria,2NP8F@2323|unclassified Bacteria	2|Bacteria	P	Ammonium Transporter Family	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
DEZH2_k127_961214_4	1408422.JHYF01000009_gene2122	1.732e-66	247.0	COG2843@1|root,COG2843@2|Bacteria,1UZW4@1239|Firmicutes,24950@186801|Clostridia,36WWA@31979|Clostridiaceae	186801|Clostridia	M	Bacterial capsule synthesis protein PGA_cap	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
DEZH2_k127_961214_17	1033810.HLPCO_002137	1.448e-26	126.0	2C7N7@1|root,32RJG@2|Bacteria	2|Bacteria	-	-	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_2
DEZH2_k127_961214_7	1268072.PSAB_03825	1.57e-45	174.0	COG3656@1|root,COG3656@2|Bacteria,1VF97@1239|Firmicutes,4HY7C@91061|Bacilli,271ZZ@186822|Paenibacillaceae	91061|Bacilli	S	Predicted periplasmic protein (DUF2271)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2271
DEZH2_k127_961214_6	660470.Theba_2260	5.012e-53	191.0	2DKYA@1|root,30VCV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_961214_19	1408823.AXUS01000014_gene1329	1.162e-11	75.0	COG1141@1|root,COG1141@2|Bacteria,1VKVT@1239|Firmicutes,24RTU@186801|Clostridia	186801|Clostridia	C	ferredoxin	fdxA	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
DEZH2_k127_961214_8	1286171.EAL2_c07880	1.032e-43	170.0	COG3945@1|root,COG3945@2|Bacteria,1V3TS@1239|Firmicutes,24HUR@186801|Clostridia	186801|Clostridia	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
DEZH2_k127_961214_14	1449343.JQLQ01000002_gene2498	4.169e-34	136.0	2AJ3X@1|root,2ZRPA@2|Bacteria,1V5Y8@1239|Firmicutes,4HQ0F@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_961214_1	1131462.DCF50_p2274	6.439e-173	550.0	COG0477@1|root,COG2814@2|Bacteria,1TPPY@1239|Firmicutes,247T9@186801|Clostridia,25ZYZ@186807|Peptococcaceae	186801|Clostridia	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
DEZH2_k127_961214_5	479437.Elen_1273	1.864e-63	222.0	COG1971@1|root,COG1971@2|Bacteria,2GNBU@201174|Actinobacteria,4CVMV@84998|Coriobacteriia	84998|Coriobacteriia	P	Probably functions as a manganese efflux pump	mntP	-	-	-	-	-	-	-	-	-	-	-	Mntp
DEZH2_k127_961214_12	767817.Desgi_0205	1.009e-38	149.0	COG0826@1|root,COG0826@2|Bacteria	2|Bacteria	O	peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	DUF3656,DUF3795,Peptidase_U32
DEZH2_k127_961214_13	1195236.CTER_0671	1.073e-37	147.0	COG2050@1|root,COG2050@2|Bacteria,1VD4J@1239|Firmicutes,24QRZ@186801|Clostridia,3WRY0@541000|Ruminococcaceae	186801|Clostridia	Q	Thioesterase superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT,DUF4442
DEZH2_k127_961214_20	1347368.HG964404_gene5066	9.168e-05	54.0	COG0737@1|root,COG0737@2|Bacteria	2|Bacteria	F	nucleotide catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	SLH
DEZH2_k127_961214_2	642492.Clole_3023	7.3e-101	336.0	COG0524@1|root,COG0524@2|Bacteria,1VS89@1239|Firmicutes,25E19@186801|Clostridia	186801|Clostridia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
DEZH2_k127_961214_9	352165.HMPREF7215_0847	7e-43	161.0	COG3422@1|root,COG3422@2|Bacteria	2|Bacteria	S	double-strand break repair	trpS	-	6.1.1.2	ko:K01867,ko:K09946	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DUF1508,tRNA-synt_1b
DEZH2_k127_9624097_2	1452535.JARD01000028_gene2287	7.196e-59	205.0	COG1834@1|root,COG1834@2|Bacteria,2GNTN@201174|Actinobacteria,4FKTM@85023|Microbacteriaceae	201174|Actinobacteria	E	Amidinotransferase	-	GO:0003674,GO:0003824,GO:0016403,GO:0016787,GO:0016810,GO:0016813	-	-	-	-	-	-	-	-	-	-	Amidinotransf
DEZH2_k127_9624097_8	411473.RUMCAL_02506	2.104e-26	120.0	COG5492@1|root,COG5492@2|Bacteria,1TS8J@1239|Firmicutes,24A7I@186801|Clostridia,3WGX5@541000|Ruminococcaceae	186801|Clostridia	N	dockerin type I repeat-containing domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new,LRR_5
DEZH2_k127_9624097_6	1033737.CAEV01000056_gene3714	4.86e-28	126.0	28IAA@1|root,2Z8CW@2|Bacteria,1TQHP@1239|Firmicutes,248TG@186801|Clostridia,36F51@31979|Clostridiaceae	186801|Clostridia	S	DHHW protein	-	-	-	-	-	-	-	-	-	-	-	-	DHHW
DEZH2_k127_9624097_10	457412.RSAG_00216	7.43e-07	59.0	29XH2@1|root,30J7P@2|Bacteria,1VSYJ@1239|Firmicutes,259SM@186801|Clostridia,3WQM3@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9624097_4	428125.CLOLEP_03339	1.267e-41	162.0	COG5036@1|root,COG5036@2|Bacteria,1V27Y@1239|Firmicutes,25D4R@186801|Clostridia	186801|Clostridia	P	VTC domain	-	-	-	-	-	-	-	-	-	-	-	-	VTC
DEZH2_k127_9624097_1	742765.HMPREF9457_03053	5.506e-59	213.0	COG1285@1|root,COG1285@2|Bacteria,1TRUW@1239|Firmicutes,248G4@186801|Clostridia,27X8D@189330|Dorea	186801|Clostridia	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
DEZH2_k127_9624097_0	742765.HMPREF9457_03054	6.603e-113	378.0	COG5337@1|root,COG5337@2|Bacteria,1UMDN@1239|Firmicutes,25GFF@186801|Clostridia	186801|Clostridia	M	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH
DEZH2_k127_9624097_11	1123009.AUID01000010_gene551	0.0002416	44.0	COG5297@1|root,COG5297@2|Bacteria,1UFT1@1239|Firmicutes,24D0R@186801|Clostridia	186801|Clostridia	G	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Dockerin_1
DEZH2_k127_9624097_7	1395513.P343_15475	1.393e-27	119.0	COG1247@1|root,COG1247@2|Bacteria,1VA66@1239|Firmicutes,4I4GT@91061|Bacilli,26Q1P@186821|Sporolactobacillaceae	91061|Bacilli	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9624097_3	293826.Amet_0452	5.644e-56	205.0	COG0484@1|root,COG0484@2|Bacteria,1V7EW@1239|Firmicutes,24JRG@186801|Clostridia,36HBF@31979|Clostridiaceae	186801|Clostridia	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
DEZH2_k127_9624097_5	1196322.A370_00856	1.151e-38	147.0	2DPD3@1|root,331JM@2|Bacteria,1VGRR@1239|Firmicutes,24KYF@186801|Clostridia,36JN4@31979|Clostridiaceae	186801|Clostridia	S	zinc-ribbon family	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_15
DEZH2_k127_9624097_9	1280663.ATVR01000022_gene2588	7.185e-10	72.0	2B6N5@1|root,31ZKN@2|Bacteria,1USDM@1239|Firmicutes,25ACW@186801|Clostridia,4C0EI@830|Butyrivibrio	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9689381_1	1392491.JIAE01000001_gene2422	3.402e-70	251.0	COG5018@1|root,COG5018@2|Bacteria,1TQJZ@1239|Firmicutes,24845@186801|Clostridia,3WM2I@541000|Ruminococcaceae	186801|Clostridia	L	Exonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
DEZH2_k127_9689381_0	1410638.JHXJ01000033_gene13	9.637e-91	327.0	COG4485@1|root,COG4485@2|Bacteria,1TRR1@1239|Firmicutes,24BHM@186801|Clostridia,3WHJ5@541000|Ruminococcaceae	186801|Clostridia	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	GtrA,YfhO
DEZH2_k127_9730261_3	411459.RUMOBE_03029	1.297e-94	321.0	COG1172@1|root,COG1172@2|Bacteria,1TPPT@1239|Firmicutes,248FJ@186801|Clostridia,3Y1F9@572511|Blautia	186801|Clostridia	P	Branched-chain amino acid transport system / permease component	yjfF	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
DEZH2_k127_9730261_1	1121115.AXVN01000010_gene2795	2.595e-112	374.0	COG1172@1|root,COG1172@2|Bacteria,1TR6F@1239|Firmicutes,2484T@186801|Clostridia,3Y10U@572511|Blautia	186801|Clostridia	P	Branched-chain amino acid transport system / permease component	ytfT	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
DEZH2_k127_9730261_0	180332.JTGN01000002_gene5406	1.047e-216	683.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia	186801|Clostridia	G	import. Responsible for energy coupling to the transport system	araG_1	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
DEZH2_k127_9730261_4	1121334.KB911067_gene183	1.013e-81	284.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,247K8@186801|Clostridia,3WHBM@541000|Ruminococcaceae	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
DEZH2_k127_9730261_2	573061.Clocel_0284	5.823e-101	338.0	arCOG06802@1|root,335UQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9730261_5	138119.DSY1172	7.359e-75	255.0	COG1528@1|root,COG1528@2|Bacteria,1V1BJ@1239|Firmicutes,24FUF@186801|Clostridia,262IN@186807|Peptococcaceae	186801|Clostridia	P	Iron-storage protein	ftnA	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
DEZH2_k127_9730261_6	509191.AEDB02000099_gene4039	2.215e-52	202.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,3WGD9@541000|Ruminococcaceae	186801|Clostridia	L	Belongs to the DEAD box helicase family	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
DEZH2_k127_9757289_0	483218.BACPEC_02357	5.178e-82	295.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142,PMT,PMT_2
DEZH2_k127_9757289_5	1380390.JIAT01000011_gene2434	0.0001686	48.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
DEZH2_k127_9757289_3	1123250.KB908442_gene1629	4.234e-11	68.0	COG2026@1|root,COG2026@2|Bacteria,1VFJM@1239|Firmicutes	1239|Firmicutes	DJ	Addiction module toxin, RelE StbE family	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
DEZH2_k127_9757289_1	1211817.CCAT010000062_gene4005	6.097e-35	136.0	COG1695@1|root,COG1695@2|Bacteria,1VAKA@1239|Firmicutes,24MVF@186801|Clostridia,36M0F@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator PadR family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
DEZH2_k127_9757289_4	768706.Desor_2332	1.093e-05	58.0	COG0772@1|root,COG0772@2|Bacteria,1V1V4@1239|Firmicutes,249VJ@186801|Clostridia,2618C@186807|Peptococcaceae	186801|Clostridia	D	Belongs to the SEDS family	rodA2	-	-	-	-	-	-	-	-	-	-	-	FTSW_RODA_SPOVE
DEZH2_k127_9761905_2	148960.XP_006960736.1	0.0001018	47.0	COG2453@1|root,KOG1716@2759|Eukaryota,3A250@33154|Opisthokonta,3P3EA@4751|Fungi,3V10W@5204|Basidiomycota	4751|Fungi	V	Dual specificity phosphatase, catalytic domain	-	-	3.1.3.16,3.1.3.48	ko:K04459,ko:K21278	ko04010,ko04726,ko05418,map04010,map04726,map05418	-	-	-	ko00000,ko00001,ko01000,ko01009	-	-	-	DSPc,Rhodanese
DEZH2_k127_9761905_3	171693.BN988_02273	0.000843	52.0	COG1653@1|root,COG1653@2|Bacteria,1TQFZ@1239|Firmicutes,4HA0U@91061|Bacilli,23IM6@182709|Oceanobacillus	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
DEZH2_k127_9761905_0	1220589.CD32_08755	1.294e-48	179.0	2C97V@1|root,32FFT@2|Bacteria,1V7BV@1239|Firmicutes,4HJBY@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9761905_1	398512.JQKC01000065_gene4747	6.604e-30	121.0	COG1592@1|root,COG1592@2|Bacteria,1VF5U@1239|Firmicutes	1239|Firmicutes	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	-
DEZH2_k127_9804745_0	411474.COPEUT_02856	4.8e-121	395.0	COG2819@1|root,COG2819@2|Bacteria,1VCPU@1239|Firmicutes,24PM8@186801|Clostridia	186801|Clostridia	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
DEZH2_k127_9804745_1	138119.DSY0575	5.898e-76	267.0	COG0577@1|root,COG0577@2|Bacteria,1TR2D@1239|Firmicutes,2481J@186801|Clostridia,260G3@186807|Peptococcaceae	186801|Clostridia	V	Permease	-	-	-	ko:K02004,ko:K11636	ko02020,map02020	M00258,M00315	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.134.6	-	-	FtsX
DEZH2_k127_9843303_1	1158602.I590_02626	5.026e-45	168.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,4HCZM@91061|Bacilli,4B0A7@81852|Enterococcaceae	91061|Bacilli	U	Part of a membrane complex involved in electron transport	-	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
DEZH2_k127_9843303_2	1163671.JAGI01000002_gene1369	7.528e-18	91.0	COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,24JVM@186801|Clostridia,36K2X@31979|Clostridiaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfG	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
DEZH2_k127_9843303_0	203119.Cthe_2433	2.196e-61	220.0	COG4660@1|root,COG4660@2|Bacteria,1TSE7@1239|Firmicutes,24972@186801|Clostridia,3WHAI@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
DEZH2_k127_9843303_3	1507.HMPREF0262_00233	2.711e-16	79.0	COG4657@1|root,COG4657@2|Bacteria,1TS06@1239|Firmicutes,247UE@186801|Clostridia,36ESS@31979|Clostridiaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
DEZH2_k127_9912687_1	1410630.JNKP01000001_gene1853	1.04e-43	166.0	COG1216@1|root,COG1216@2|Bacteria,1UYRR@1239|Firmicutes,24BJN@186801|Clostridia,27T8X@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
DEZH2_k127_9912687_0	747365.Thena_0396	3.901e-155	499.0	COG1215@1|root,COG1216@1|root,COG2227@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,COG2227@2|Bacteria,1UYRR@1239|Firmicutes,249T1@186801|Clostridia,42HAT@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K07011,ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,Methyltransf_23
DEZH2_k127_9912726_0	1392491.JIAE01000001_gene660	2.258e-140	453.0	COG0826@1|root,COG0826@2|Bacteria,1TPRE@1239|Firmicutes,248I3@186801|Clostridia,3WGFB@541000|Ruminococcaceae	186801|Clostridia	O	Peptidase U32	yhbU_1	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
DEZH2_k127_9912726_1	1392491.JIAE01000001_gene659	4.708e-140	455.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,2493B@186801|Clostridia,3WHZ1@541000|Ruminococcaceae	186801|Clostridia	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
DEZH2_k127_9912726_2	1392491.JIAE01000001_gene658	1.455e-67	231.0	COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,248EB@186801|Clostridia,3WGEU@541000|Ruminococcaceae	186801|Clostridia	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
DEZH2_k127_9922349_0	335541.Swol_1629	6.519e-138	441.0	COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,42K12@68298|Syntrophomonadaceae	186801|Clostridia	C	TIGRFAM hydro-lyase, Fe-S type, tartrate fumarate subfamily, alpha subunit	-	-	4.2.1.2,4.2.1.32	ko:K01677,ko:K03779	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
DEZH2_k127_9922349_1	335541.Swol_1628	2.424e-101	332.0	COG1838@1|root,COG1838@2|Bacteria,1TSJ8@1239|Firmicutes,25CDD@186801|Clostridia	186801|Clostridia	C	L( )-tartrate dehydratase subunit beta	ttdB	-	4.2.1.2,4.2.1.32	ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
DEZH2_k127_9922349_2	1410650.JHWL01000038_gene2534	1.126e-24	109.0	COG0406@1|root,COG0406@2|Bacteria,1VCAW@1239|Firmicutes,25DTN@186801|Clostridia,4BZ6U@830|Butyrivibrio	186801|Clostridia	G	Histidine phosphatase superfamily (branch 1)	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
DEZH2_k127_9933719_0	1123009.AUID01000029_gene426	1.248e-73	264.0	COG5001@1|root,COG5001@2|Bacteria,1UNXG@1239|Firmicutes,25H4Z@186801|Clostridia	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
DEZH2_k127_9933719_1	167546.P9301_08591	1.46e-12	76.0	COG0558@1|root,COG0558@2|Bacteria,1GDBH@1117|Cyanobacteria,1MMSN@1212|Prochloraceae	1117|Cyanobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
DEZH2_k127_9942908_1	138119.DSY4677	2.346e-140	448.0	COG1146@1|root,COG1146@2|Bacteria,1UIFT@1239|Firmicutes,25EM9@186801|Clostridia	186801|Clostridia	C	Domain of unknown function (DUF2703)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2703
DEZH2_k127_9942908_0	485916.Dtox_4283	1.21e-176	557.0	COG0701@1|root,COG0701@2|Bacteria,1TQC7@1239|Firmicutes,24A02@186801|Clostridia,2614E@186807|Peptococcaceae	186801|Clostridia	S	permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
DEZH2_k127_9975315_6	656519.Halsa_0641	7.609e-11	63.0	COG1216@1|root,COG1216@2|Bacteria,1UYRR@1239|Firmicutes,249T1@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K07011,ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,Methyltransf_23
DEZH2_k127_9975315_5	1117379.BABA_01660	7.584e-55	200.0	COG1216@1|root,COG1216@2|Bacteria,1V3IY@1239|Firmicutes,4HVIA@91061|Bacilli,1ZH41@1386|Bacillus	91061|Bacilli	S	Glycosyltransferase like family 2	welB	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DEZH2_k127_9975315_2	1121334.KB911073_gene1919	3.263e-175	568.0	COG1086@1|root,COG1086@2|Bacteria,1TR3W@1239|Firmicutes,247PW@186801|Clostridia,3WGZ4@541000|Ruminococcaceae	186801|Clostridia	GM	Polysaccharide biosynthesis protein	capD	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
DEZH2_k127_9975315_4	272558.10176340	2.965e-102	336.0	COG2148@1|root,COG2148@2|Bacteria,1TQX9@1239|Firmicutes,4HAF1@91061|Bacilli,1ZQHD@1386|Bacillus	91061|Bacilli	M	Bacterial sugar transferase	capM	-	-	ko:K13012	-	-	-	-	ko00000,ko01005	-	-	-	Bac_transf
DEZH2_k127_9975315_3	1304880.JAGB01000001_gene944	2.619e-139	447.0	COG0451@1|root,COG0451@2|Bacteria,1UKK9@1239|Firmicutes,25G3F@186801|Clostridia	186801|Clostridia	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
DEZH2_k127_9975315_1	357809.Cphy_3505	2.507e-182	577.0	COG0438@1|root,COG0438@2|Bacteria,1UTQH@1239|Firmicutes,24BT3@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1
DEZH2_k127_9975315_0	994573.T472_0204635	1.596e-187	589.0	COG1086@1|root,COG1086@2|Bacteria,1TPTC@1239|Firmicutes,247YC@186801|Clostridia,36VQ0@31979|Clostridiaceae	186801|Clostridia	M	biosynthesis protein	capD	-	5.1.3.2	ko:K17716	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00362	R00291	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Polysacc_syn_2C,Polysacc_synt_2
## 2041 queries scanned
## Total time (seconds): 6.44561505317688
## Rate: 316.65 q/s